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Search of human proteins with 168229256
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|168229256 ankyrin repeat domain 41 [Homo sapiens]
(615 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|168229256 ankyrin repeat domain 41 [Homo sapiens] 1263 0.0
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 67 5e-11
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 67 5e-11
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 67 5e-11
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 67 5e-11
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 67 5e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 65 2e-10
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 65 2e-10
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 65 2e-10
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 64 4e-10
gi|134244285 Notch homolog 3 [Homo sapiens] 63 7e-10
gi|155969701 espin-like [Homo sapiens] 63 9e-10
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 62 1e-09
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 62 1e-09
gi|55770876 notch4 preproprotein [Homo sapiens] 62 2e-09
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 62 2e-09
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 61 3e-09
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 61 3e-09
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 61 3e-09
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 61 3e-09
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 60 5e-09
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 60 5e-09
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 60 5e-09
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 59 2e-08
gi|110431370 espin [Homo sapiens] 58 2e-08
gi|70995241 ankyrin repeat domain 10 [Homo sapiens] 57 4e-08
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 57 5e-08
gi|34304383 Usher syndrome 1G protein [Homo sapiens] 57 5e-08
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 55 1e-07
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 55 1e-07
>gi|168229256 ankyrin repeat domain 41 [Homo sapiens]
Length = 615
Score = 1263 bits (3269), Expect = 0.0
Identities = 615/615 (100%), Positives = 615/615 (100%)
Query: 1 MCSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLG 60
MCSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLG
Sbjct: 1 MCSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLG 60
Query: 61 ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG
Sbjct: 61 ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
Query: 121 HLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGDNR 180
HLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGDNR
Sbjct: 121 HLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGDNR 180
Query: 181 DIGLEADPGPPSLPVPLETVDKHGSSASPPGHWDYSSDASFVTAVEVSGAEDPASDTPPW 240
DIGLEADPGPPSLPVPLETVDKHGSSASPPGHWDYSSDASFVTAVEVSGAEDPASDTPPW
Sbjct: 181 DIGLEADPGPPSLPVPLETVDKHGSSASPPGHWDYSSDASFVTAVEVSGAEDPASDTPPW 240
Query: 241 AGSLPPTRQGLLHVVHANQRVPRSQGTEAELNARLQALTLTPPNAAGFQSSPSSMPLLDR 300
AGSLPPTRQGLLHVVHANQRVPRSQGTEAELNARLQALTLTPPNAAGFQSSPSSMPLLDR
Sbjct: 241 AGSLPPTRQGLLHVVHANQRVPRSQGTEAELNARLQALTLTPPNAAGFQSSPSSMPLLDR 300
Query: 301 SPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATLWLTEDEASSTGGREPVGPCRHLPVST 360
SPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATLWLTEDEASSTGGREPVGPCRHLPVST
Sbjct: 301 SPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATLWLTEDEASSTGGREPVGPCRHLPVST 360
Query: 361 VSDLELLKGLRALGENPHPITPFTRQLYHQQLEEAQIAPGPEFSGHSLELAAALRTGCIP 420
VSDLELLKGLRALGENPHPITPFTRQLYHQQLEEAQIAPGPEFSGHSLELAAALRTGCIP
Sbjct: 361 VSDLELLKGLRALGENPHPITPFTRQLYHQQLEEAQIAPGPEFSGHSLELAAALRTGCIP 420
Query: 421 DVQADEDALAQQFEQPDPARRWREGVVKSSFTYLLLDPRETQDLPARAFSLTPAERLQTF 480
DVQADEDALAQQFEQPDPARRWREGVVKSSFTYLLLDPRETQDLPARAFSLTPAERLQTF
Sbjct: 421 DVQADEDALAQQFEQPDPARRWREGVVKSSFTYLLLDPRETQDLPARAFSLTPAERLQTF 480
Query: 481 IRAIFYVGKGTRARPYVHLWEALGHHGRSRKQPHQACPKVRQILDIWASGCGVVSLHCFQ 540
IRAIFYVGKGTRARPYVHLWEALGHHGRSRKQPHQACPKVRQILDIWASGCGVVSLHCFQ
Sbjct: 481 IRAIFYVGKGTRARPYVHLWEALGHHGRSRKQPHQACPKVRQILDIWASGCGVVSLHCFQ 540
Query: 541 HVVAVEAYTREACIVEALGIQTLTNQKQGHCYGVVAGWPPARRRRLGVHLLHRALLVFLA 600
HVVAVEAYTREACIVEALGIQTLTNQKQGHCYGVVAGWPPARRRRLGVHLLHRALLVFLA
Sbjct: 541 HVVAVEAYTREACIVEALGIQTLTNQKQGHCYGVVAGWPPARRRRLGVHLLHRALLVFLA 600
Query: 601 EGERQLHPQDIQARG 615
EGERQLHPQDIQARG
Sbjct: 601 EGERQLHPQDIQARG 615
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 67.0 bits (162), Expect = 5e-11
Identities = 45/120 (37%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL G P+ +G +H+AA R +LL+ GG NA SV+ +TPLH+
Sbjct: 618 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR---SLLQYGGSANAESVQGVTPLHL 674
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G + LLLS+ A+ L ++ GL PL L Q+GH+ A VL TR+G
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Score = 58.9 bits (141), Expect = 1e-08
Identities = 38/132 (28%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R ++ LL+ +P+++ + G +H+AA H L LL +G N
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLLNRGASVN 266
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+TPLH+A+ G + LLL +GA + +D L PL A + GH+ + +L D
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326
Query: 131 LDTRTRTRTRIG 142
+ +T+ G
Sbjct: 327 HGAPIQAKTKNG 338
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA N ++G +H+A+ + +R L L +G ++ + LTPLH AA
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL---LDRGAQIETKTKDELTPLHCAAR 314
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
G R E+LL GA + ++GL P+ +A Q HL+C R+L D
Sbjct: 315 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 361
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/106 (34%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL A+PNL G +H+AA H + + ALL + + + TPLHV
Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGH---VETVLALLEKEASQACMTKKGFTPLHV 575
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA +G R ELLL + A P ++GL PL +A+ +L+ ++L
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/120 (32%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GA PN+ +H+AA A H + L L+ NA++ + TPLH
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHC 509
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G ++LLL A+P L G PL +A ++GH+E L + + T+ G
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL GA ++G + +H+AA H L C+ LL+ + + +++ LTPLHVA
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDH---LDCVRLLLQYDAEIDDITLDHLTPLHVA 378
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A G R ++LL +GA P R +G PL +A ++ H+ +L
Sbjct: 379 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 423
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E LL+ GA + V E G +H+A+ H L + LL++G PN
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH---LPIVKNLLQRGASPN 464
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+V+ TPLH+AA G + LL A + +D PL A + GH ++L +
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 131 LDTRTRTRTRIG 142
+ T G
Sbjct: 525 NNANPNLATTAG 536
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/106 (34%), Positives = 53/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL+ A+ + + D +H+AA H R + LL +G PN+R++ TPLH+
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHI 410
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A R +ELLL GA + GL PL +A GHL + L
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 15/160 (9%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V ELL + G A+H+AA A +R L+ G + NA+S
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR---ELVNYGANVNAQS 141
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
+ TPL++AA ++ LL GA+ + +DG PL +ALQQGH L + T
Sbjct: 142 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 201
Query: 134 RTRTR------------TRIGAETQEPEPAPGTPGLSGPT 161
+ + R TR A + +P P +G T
Sbjct: 202 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 241
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL A PN ++G +H+A H L + LL +GG P++ + TPLH+A
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAV---HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 642
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LL G G+ PL LA Q+GH E +L
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA PN +G +H+A H +R + LL+ G +A + LTPLHVA+
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 446
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G ++ LL +GA P + + PL +A + GH E A+ L
Sbjct: 447 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 26/153 (16%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGL----------------- 56
A +E V+ LL GA+ N+ EDG + +A H +
Sbjct: 151 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 210
Query: 57 ---------RCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQ 107
R LL+ +P+ S TPLH+AA + +LLL++GA Q
Sbjct: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 270
Query: 108 DGLRPLDLALQQGHLECARVLQDLDTRTRTRTR 140
+G+ PL +A ++G++ R+L D + T+T+
Sbjct: 271 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 303
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/118 (33%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A RE V LL A + + G +H+AA +R LL + PN
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK---VRVAELLLERDAHPN 596
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LTPLHVA ++LLL +G P +G PL +A +Q +E AR L
Sbjct: 597 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Score = 47.0 bits (110), Expect = 5e-05
Identities = 37/140 (26%), Positives = 57/140 (40%), Gaps = 3/140 (2%)
Query: 3 SEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGAL 62
S ++ L A R + LL+ A N +D +H AA H ++ L
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 522
Query: 63 LRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHL 122
L +PN + TPLH+AA G + LL + A A + G PL +A + G +
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
Query: 123 ECARVLQDLDTRTRTRTRIG 142
A +L + D + G
Sbjct: 583 RVAELLLERDAHPNAAGKNG 602
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
L++ G + G +H+A+ H ++ + LL+ D NA++ +PLH AA
Sbjct: 720 LIKHGVMVDATTRMGYTPLHVAS---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 776
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRT 135
G + LLL GA P DG PL +A + G++ VL+ + T
Sbjct: 777 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET 826
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ + LL+ G N G +HLAA H + LL + + N
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE---MVALLLSKQANGN 695
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLH+ A G ++L+ G + G PL +A G+++ + L
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
Query: 131 LDTRTRTRTRIG 142
+T++G
Sbjct: 756 HQADVNAKTKLG 767
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/120 (30%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA +D +H AA H +R LL G A++ L+P+H+
Sbjct: 288 VRLLLDRGAQIETKTKDELTPLHCAARNGH---VRISEILLDHGAPIQAKTKNGLSPIHM 344
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA + LLL A+ D L PL +A GH A+VL D + +R G
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 67.0 bits (162), Expect = 5e-11
Identities = 45/120 (37%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL G P+ +G +H+AA R +LL+ GG NA SV+ +TPLH+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR---SLLQYGGSANAESVQGVTPLHL 641
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G + LLLS+ A+ L ++ GL PL L Q+GH+ A VL TR+G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Score = 58.9 bits (141), Expect = 1e-08
Identities = 38/132 (28%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R ++ LL+ +P+++ + G +H+AA H L LL +G N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLLNRGASVN 233
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+TPLH+A+ G + LLL +GA + +D L PL A + GH+ + +L D
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 131 LDTRTRTRTRIG 142
+ +T+ G
Sbjct: 294 HGAPIQAKTKNG 305
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA N ++G +H+A+ + +R L L +G ++ + LTPLH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL---LDRGAQIETKTKDELTPLHCAAR 281
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
G R E+LL GA + ++GL P+ +A Q HL+C R+L D
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/106 (34%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL A+PNL G +H+AA H + + ALL + + + TPLHV
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGH---VETVLALLEKEASQACMTKKGFTPLHV 542
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA +G R ELLL + A P ++GL PL +A+ +L+ ++L
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/120 (32%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GA PN+ +H+AA A H + L L+ NA++ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHC 476
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G ++LLL A+P L G PL +A ++GH+E L + + T+ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL GA ++G + +H+AA H L C+ LL+ + + +++ LTPLHVA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDH---LDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A G R ++LL +GA P R +G PL +A ++ H+ +L
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E LL+ GA + V E G +H+A+ H L + LL++G PN
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH---LPIVKNLLQRGASPN 431
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+V+ TPLH+AA G + LL A + +D PL A + GH ++L +
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 131 LDTRTRTRTRIG 142
+ T G
Sbjct: 492 NNANPNLATTAG 503
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/106 (34%), Positives = 53/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL+ A+ + + D +H+AA H R + LL +G PN+R++ TPLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHI 377
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A R +ELLL GA + GL PL +A GHL + L
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 15/160 (9%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V ELL + G A+H+AA A +R L+ G + NA+S
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR---ELVNYGANVNAQS 108
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
+ TPL++AA ++ LL GA+ + +DG PL +ALQQGH L + T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 134 RTRTR------------TRIGAETQEPEPAPGTPGLSGPT 161
+ + R TR A + +P P +G T
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL A PN ++G +H+A H L + LL +GG P++ + TPLH+A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAV---HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LL G G+ PL LA Q+GH E +L
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA PN +G +H+A H +R + LL+ G +A + LTPLHVA+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G ++ LL +GA P + + PL +A + GH E A+ L
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 26/153 (16%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGL----------------- 56
A +E V+ LL GA+ N+ EDG + +A H +
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177
Query: 57 ---------RCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQ 107
R LL+ +P+ S TPLH+AA + +LLL++GA Q
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 108 DGLRPLDLALQQGHLECARVLQDLDTRTRTRTR 140
+G+ PL +A ++G++ R+L D + T+T+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/118 (33%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A RE V LL A + + G +H+AA +R LL + PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK---VRVAELLLERDAHPN 563
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LTPLHVA ++LLL +G P +G PL +A +Q +E AR L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 47.0 bits (110), Expect = 5e-05
Identities = 37/140 (26%), Positives = 57/140 (40%), Gaps = 3/140 (2%)
Query: 3 SEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGAL 62
S ++ L A R + LL+ A N +D +H AA H ++ L
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 63 LRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHL 122
L +PN + TPLH+AA G + LL + A A + G PL +A + G +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 123 ECARVLQDLDTRTRTRTRIG 142
A +L + D + G
Sbjct: 550 RVAELLLERDAHPNAAGKNG 569
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
L++ G + G +H+A+ H ++ + LL+ D NA++ +PLH AA
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVAS---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRT 135
G + LLL GA P DG PL +A + G++ VL+ + T
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET 793
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ + LL+ G N G +HLAA H + LL + + N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE---MVALLLSKQANGN 662
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLH+ A G ++L+ G + G PL +A G+++ + L
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 131 LDTRTRTRTRIG 142
+T++G
Sbjct: 723 HQADVNAKTKLG 734
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/120 (30%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA +D +H AA H +R LL G A++ L+P+H+
Sbjct: 255 VRLLLDRGAQIETKTKDELTPLHCAARNGH---VRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA + LLL A+ D L PL +A GH A+VL D + +R G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 67.0 bits (162), Expect = 5e-11
Identities = 45/120 (37%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL G P+ +G +H+AA R +LL+ GG NA SV+ +TPLH+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR---SLLQYGGSANAESVQGVTPLHL 641
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G + LLLS+ A+ L ++ GL PL L Q+GH+ A VL TR+G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Score = 58.9 bits (141), Expect = 1e-08
Identities = 38/132 (28%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R ++ LL+ +P+++ + G +H+AA H L LL +G N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLLNRGASVN 233
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+TPLH+A+ G + LLL +GA + +D L PL A + GH+ + +L D
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 131 LDTRTRTRTRIG 142
+ +T+ G
Sbjct: 294 HGAPIQAKTKNG 305
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA N ++G +H+A+ + +R L L +G ++ + LTPLH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL---LDRGAQIETKTKDELTPLHCAAR 281
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
G R E+LL GA + ++GL P+ +A Q HL+C R+L D
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/106 (34%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL A+PNL G +H+AA H + + ALL + + + TPLHV
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGH---VETVLALLEKEASQACMTKKGFTPLHV 542
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA +G R ELLL + A P ++GL PL +A+ +L+ ++L
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/120 (32%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GA PN+ +H+AA A H + L L+ NA++ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHC 476
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G ++LLL A+P L G PL +A ++GH+E L + + T+ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL GA ++G + +H+AA H L C+ LL+ + + +++ LTPLHVA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDH---LDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A G R ++LL +GA P R +G PL +A ++ H+ +L
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E LL+ GA + V E G +H+A+ H L + LL++G PN
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH---LPIVKNLLQRGASPN 431
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+V+ TPLH+AA G + LL A + +D PL A + GH ++L +
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 131 LDTRTRTRTRIG 142
+ T G
Sbjct: 492 NNANPNLATTAG 503
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/106 (34%), Positives = 53/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL+ A+ + + D +H+AA H R + LL +G PN+R++ TPLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHI 377
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A R +ELLL GA + GL PL +A GHL + L
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 15/160 (9%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V ELL + G A+H+AA A +R L+ G + NA+S
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR---ELVNYGANVNAQS 108
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
+ TPL++AA ++ LL GA+ + +DG PL +ALQQGH L + T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 134 RTRTR------------TRIGAETQEPEPAPGTPGLSGPT 161
+ + R TR A + +P P +G T
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL A PN ++G +H+A H L + LL +GG P++ + TPLH+A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAV---HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LL G G+ PL LA Q+GH E +L
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA PN +G +H+A H +R + LL+ G +A + LTPLHVA+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G ++ LL +GA P + + PL +A + GH E A+ L
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 26/153 (16%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGL----------------- 56
A +E V+ LL GA+ N+ EDG + +A H +
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177
Query: 57 ---------RCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQ 107
R LL+ +P+ S TPLH+AA + +LLL++GA Q
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 108 DGLRPLDLALQQGHLECARVLQDLDTRTRTRTR 140
+G+ PL +A ++G++ R+L D + T+T+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/118 (33%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A RE V LL A + + G +H+AA +R LL + PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK---VRVAELLLERDAHPN 563
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LTPLHVA ++LLL +G P +G PL +A +Q +E AR L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 47.0 bits (110), Expect = 5e-05
Identities = 37/140 (26%), Positives = 57/140 (40%), Gaps = 3/140 (2%)
Query: 3 SEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGAL 62
S ++ L A R + LL+ A N +D +H AA H ++ L
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 63 LRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHL 122
L +PN + TPLH+AA G + LL + A A + G PL +A + G +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 123 ECARVLQDLDTRTRTRTRIG 142
A +L + D + G
Sbjct: 550 RVAELLLERDAHPNAAGKNG 569
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
L++ G + G +H+A+ H ++ + LL+ D NA++ +PLH AA
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVAS---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRT 135
G + LLL GA P DG PL +A + G++ VL+ + T
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET 793
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ + LL+ G N G +HLAA H + LL + + N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE---MVALLLSKQANGN 662
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLH+ A G ++L+ G + G PL +A G+++ + L
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 131 LDTRTRTRTRIG 142
+T++G
Sbjct: 723 HQADVNAKTKLG 734
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/120 (30%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA +D +H AA H +R LL G A++ L+P+H+
Sbjct: 255 VRLLLDRGAQIETKTKDELTPLHCAARNGH---VRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA + LLL A+ D L PL +A GH A+VL D + +R G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 67.0 bits (162), Expect = 5e-11
Identities = 45/120 (37%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL G P+ +G +H+AA R +LL+ GG NA SV+ +TPLH+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR---SLLQYGGSANAESVQGVTPLHL 641
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G + LLLS+ A+ L ++ GL PL L Q+GH+ A VL TR+G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Score = 58.9 bits (141), Expect = 1e-08
Identities = 38/132 (28%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R ++ LL+ +P+++ + G +H+AA H L LL +G N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLLNRGASVN 233
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+TPLH+A+ G + LLL +GA + +D L PL A + GH+ + +L D
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 131 LDTRTRTRTRIG 142
+ +T+ G
Sbjct: 294 HGAPIQAKTKNG 305
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA N ++G +H+A+ + +R L L +G ++ + LTPLH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL---LDRGAQIETKTKDELTPLHCAAR 281
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
G R E+LL GA + ++GL P+ +A Q HL+C R+L D
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/106 (34%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL A+PNL G +H+AA H + + ALL + + + TPLHV
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGH---VETVLALLEKEASQACMTKKGFTPLHV 542
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA +G R ELLL + A P ++GL PL +A+ +L+ ++L
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/120 (32%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GA PN+ +H+AA A H + L L+ NA++ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHC 476
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G ++LLL A+P L G PL +A ++GH+E L + + T+ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL GA ++G + +H+AA H L C+ LL+ + + +++ LTPLHVA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDH---LDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A G R ++LL +GA P R +G PL +A ++ H+ +L
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E LL+ GA + V E G +H+A+ H L + LL++G PN
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH---LPIVKNLLQRGASPN 431
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+V+ TPLH+AA G + LL A + +D PL A + GH ++L +
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 131 LDTRTRTRTRIG 142
+ T G
Sbjct: 492 NNANPNLATTAG 503
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/106 (34%), Positives = 53/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL+ A+ + + D +H+AA H R + LL +G PN+R++ TPLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHI 377
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A R +ELLL GA + GL PL +A GHL + L
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 15/160 (9%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V ELL + G A+H+AA A +R L+ G + NA+S
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR---ELVNYGANVNAQS 108
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
+ TPL++AA ++ LL GA+ + +DG PL +ALQQGH L + T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 134 RTRTR------------TRIGAETQEPEPAPGTPGLSGPT 161
+ + R TR A + +P P +G T
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL A PN ++G +H+A H L + LL +GG P++ + TPLH+A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAV---HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LL G G+ PL LA Q+GH E +L
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA PN +G +H+A H +R + LL+ G +A + LTPLHVA+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G ++ LL +GA P + + PL +A + GH E A+ L
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 26/153 (16%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGL----------------- 56
A +E V+ LL GA+ N+ EDG + +A H +
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177
Query: 57 ---------RCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQ 107
R LL+ +P+ S TPLH+AA + +LLL++GA Q
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 108 DGLRPLDLALQQGHLECARVLQDLDTRTRTRTR 140
+G+ PL +A ++G++ R+L D + T+T+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/118 (33%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A RE V LL A + + G +H+AA +R LL + PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK---VRVAELLLERDAHPN 563
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LTPLHVA ++LLL +G P +G PL +A +Q +E AR L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 47.0 bits (110), Expect = 5e-05
Identities = 37/140 (26%), Positives = 57/140 (40%), Gaps = 3/140 (2%)
Query: 3 SEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGAL 62
S ++ L A R + LL+ A N +D +H AA H ++ L
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 63 LRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHL 122
L +PN + TPLH+AA G + LL + A A + G PL +A + G +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 123 ECARVLQDLDTRTRTRTRIG 142
A +L + D + G
Sbjct: 550 RVAELLLERDAHPNAAGKNG 569
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
L++ G + G +H+A+ H ++ + LL+ D NA++ +PLH AA
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVAS---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRT 135
G + LLL GA P DG PL +A + G++ VL+ + T
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET 793
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ + LL+ G N G +HLAA H + LL + + N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE---MVALLLSKQANGN 662
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLH+ A G ++L+ G + G PL +A G+++ + L
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 131 LDTRTRTRTRIG 142
+T++G
Sbjct: 723 HQADVNAKTKLG 734
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/120 (30%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA +D +H AA H +R LL G A++ L+P+H+
Sbjct: 255 VRLLLDRGAQIETKTKDELTPLHCAARNGH---VRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA + LLL A+ D L PL +A GH A+VL D + +R G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 67.0 bits (162), Expect = 5e-11
Identities = 45/120 (37%), Positives = 63/120 (52%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL G P+ +G +H+AA R +LL+ GG NA SV+ +TPLH+
Sbjct: 585 VKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR---SLLQYGGSANAESVQGVTPLHL 641
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G + LLLS+ A+ L ++ GL PL L Q+GH+ A VL TR+G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Score = 58.9 bits (141), Expect = 1e-08
Identities = 38/132 (28%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R ++ LL+ +P+++ + G +H+AA H L LL +G N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLLNRGASVN 233
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+TPLH+A+ G + LLL +GA + +D L PL A + GH+ + +L D
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 131 LDTRTRTRTRIG 142
+ +T+ G
Sbjct: 294 HGAPIQAKTKNG 305
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA N ++G +H+A+ + +R L L +G ++ + LTPLH AA
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL---LDRGAQIETKTKDELTPLHCAAR 281
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
G R E+LL GA + ++GL P+ +A Q HL+C R+L D
Sbjct: 282 NGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/106 (34%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL A+PNL G +H+AA H + + ALL + + + TPLHV
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGH---VETVLALLEKEASQACMTKKGFTPLHV 542
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA +G R ELLL + A P ++GL PL +A+ +L+ ++L
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/120 (32%), Positives = 59/120 (49%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GA PN+ +H+AA A H + L L+ NA++ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL---LQNKAKVNAKAKDDQTPLHC 476
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G ++LLL A+P L G PL +A ++GH+E L + + T+ G
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL GA ++G + +H+AA H L C+ LL+ + + +++ LTPLHVA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDH---LDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A G R ++LL +GA P R +G PL +A ++ H+ +L
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E LL+ GA + V E G +H+A+ H L + LL++G PN
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH---LPIVKNLLQRGASPN 431
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+V+ TPLH+AA G + LL A + +D PL A + GH ++L +
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 131 LDTRTRTRTRIG 142
+ T G
Sbjct: 492 NNANPNLATTAG 503
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/106 (34%), Positives = 53/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL+ A+ + + D +H+AA H R + LL +G PN+R++ TPLH+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALNGFTPLHI 377
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A R +ELLL GA + GL PL +A GHL + L
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/160 (29%), Positives = 70/160 (43%), Gaps = 15/160 (9%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V ELL + G A+H+AA A +R L+ G + NA+S
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR---ELVNYGANVNAQS 108
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
+ TPL++AA ++ LL GA+ + +DG PL +ALQQGH L + T
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT 168
Query: 134 RTRTR------------TRIGAETQEPEPAPGTPGLSGPT 161
+ + R TR A + +P P +G T
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL A PN ++G +H+A H L + LL +GG P++ + TPLH+A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAV---HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIA 609
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LL G G+ PL LA Q+GH E +L
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 53.5 bits (127), Expect = 6e-07
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA PN +G +H+A H +R + LL+ G +A + LTPLHVA+
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNH---VRVMELLLKTGASIDAVTESGLTPLHVASF 413
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G ++ LL +GA P + + PL +A + GH E A+ L
Sbjct: 414 MGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/153 (26%), Positives = 66/153 (43%), Gaps = 26/153 (16%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGL----------------- 56
A +E V+ LL GA+ N+ EDG + +A H +
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPAL 177
Query: 57 ---------RCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQ 107
R LL+ +P+ S TPLH+AA + +LLL++GA Q
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ 237
Query: 108 DGLRPLDLALQQGHLECARVLQDLDTRTRTRTR 140
+G+ PL +A ++G++ R+L D + T+T+
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTK 270
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/118 (33%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A RE V LL A + + G +H+AA +R LL + PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK---VRVAELLLERDAHPN 563
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A LTPLHVA ++LLL +G P +G PL +A +Q +E AR L
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 47.0 bits (110), Expect = 5e-05
Identities = 37/140 (26%), Positives = 57/140 (40%), Gaps = 3/140 (2%)
Query: 3 SEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGAL 62
S ++ L A R + LL+ A N +D +H AA H ++ L
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL--- 489
Query: 63 LRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHL 122
L +PN + TPLH+AA G + LL + A A + G PL +A + G +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Query: 123 ECARVLQDLDTRTRTRTRIG 142
A +L + D + G
Sbjct: 550 RVAELLLERDAHPNAAGKNG 569
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
L++ G + G +H+A+ H ++ + LL+ D NA++ +PLH AA
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVAS---HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ 743
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRT 135
G + LLL GA P DG PL +A + G++ VL+ + T
Sbjct: 744 QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDET 793
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ + LL+ G N G +HLAA H + LL + + N
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE---MVALLLSKQANGN 662
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLH+ A G ++L+ G + G PL +A G+++ + L
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 131 LDTRTRTRTRIG 142
+T++G
Sbjct: 723 HQADVNAKTKLG 734
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/120 (30%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA +D +H AA H +R LL G A++ L+P+H+
Sbjct: 255 VRLLLDRGAQIETKTKDELTPLHCAARNGH---VRISEILLDHGAPIQAKTKNGLSPIHM 311
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA + LLL A+ D L PL +A GH A+VL D + +R G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 65.1 bits (157), Expect = 2e-10
Identities = 40/125 (32%), Positives = 68/125 (54%), Gaps = 3/125 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V+ELL G+ + + G A+H+A+ A ++ L+++G + NA+S
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK---VLVKEGANINAQS 106
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPL++AA ++ LL GA+ + +DG PL +ALQQGH + +L + DT
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166
Query: 134 RTRTR 138
+ + R
Sbjct: 167 KGKVR 171
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/117 (34%), Positives = 61/117 (52%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL+ GA P++ G A+H+AA A +RCL LR G +AR+ E TPLH+A+
Sbjct: 429 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCL---LRNGALVDARAREEQTPLHIASR 485
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G ++LLL A P +G PL ++ ++G ++ A VL + T+ G
Sbjct: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
Score = 60.5 bits (145), Expect = 5e-09
Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA + +G +H+A+ + ++ L L +GG +A++ + LTPLH AA
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL---LDRGGQIDAKTRDGLTPLHCAAR 287
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + +ELLL +GA R ++GL PL +A Q H+EC + L
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/120 (29%), Positives = 62/120 (51%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V E L+ G D N ++G A+HLAA H + + LL +G ++ + + T LH+
Sbjct: 26 VVEYLKGGIDINTCNQNGLNALHLAAKEGH---VGLVQELLGRGSSVDSATKKGNTALHI 82
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
A+ G +++L+ +GA+ + Q+G PL +A Q+ H++ + L + T T G
Sbjct: 83 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142
Score = 53.1 bits (126), Expect = 7e-07
Identities = 36/106 (33%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ A + V D A+H+AA H R + L L + +PNAR++ TPLH+
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFTPLHI 383
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A + +ELL+ GA + GL P+ +A GHL +L
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Score = 53.1 bits (126), Expect = 7e-07
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA P+ ++G +H+AA ++ LL G + N + + +TPLH+A+
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQ---MQIASTLLNYGAETNIVTKQGVTPLHLASQ 650
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G + LLL +GA+ + + GL L LA Q+ + A +L T++G
Sbjct: 651 EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
++G +H+AA H + LL +G P+A + TPLH+AA + LL+
Sbjct: 573 KNGLTPLHVAA---HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
GA+ + + G+ PL LA Q+GH + +L D T+ G
Sbjct: 630 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA+ ++ + G ++HLAA + L + G D +A + TPL VA
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLAA---QEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 716
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
+G + + LL QGA+ + ++G PL A QQGH VL + T G
Sbjct: 717 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
Score = 50.8 bits (120), Expect = 4e-06
Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 34 NLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLE 93
N E G +H+AA H + LL +G + + +TPLHVA+ G ++
Sbjct: 206 NRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 94 LLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
LLL +G + +DGL PL A + GH + +L + RT+ G
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Score = 50.8 bits (120), Expect = 4e-06
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L + RE + LL GA +L + G +H+AA L LL++ +
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG---SLDVAKLLLQRRAAAD 569
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLHVAA + ++ LLL +GA P ++G PL +A ++ ++ A L +
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629
Query: 131 LDTRTRTRTRIG 142
T T+ G
Sbjct: 630 YGAETNIVTKQG 641
Score = 50.4 bits (119), Expect = 5e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R VE LL GA ++G + +H+AA H + C+ LL+ +
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH---VECVKHLLQHKAPVD 338
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
+++ LT LHVAA G R +LLL + A+P R +G PL +A ++ ++ +L
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 396
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/118 (28%), Positives = 55/118 (46%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E L++ GA + E G +H+AA H L + LL+ G P+
Sbjct: 381 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH---LNIVLLLLQNGASPD 437
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
++ T LH+AA G + LL GA R ++ PL +A + G E ++L
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 3/126 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E++ + L + GAD + + G + +A H ++ + LL+QG + NA++
Sbjct: 681 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC---HYGNVKMVNFLLKQGANVNAKT 737
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPLH AA G + +LL GA P +G L +A + G++ L+ +
Sbjct: 738 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 797
Query: 134 RTRTRT 139
T T
Sbjct: 798 EVTTTT 803
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL A+PN +G +H+A ++ + L++ G A + LTP+HVAA
Sbjct: 363 LLDKRANPNARALNGFTPLHIACKKNR---IKVMELLVKYGASIQAITESGLTPIHVAAF 419
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + LLL GA P + + G L +A + G +E R L
Sbjct: 420 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 65.1 bits (157), Expect = 2e-10
Identities = 40/125 (32%), Positives = 68/125 (54%), Gaps = 3/125 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V+ELL G+ + + G A+H+A+ A ++ L+++G + NA+S
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK---VLVKEGANINAQS 127
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPL++AA ++ LL GA+ + +DG PL +ALQQGH + +L + DT
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 134 RTRTR 138
+ + R
Sbjct: 188 KGKVR 192
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/117 (34%), Positives = 61/117 (52%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL+ GA P++ G A+H+AA A +RCL LR G +AR+ E TPLH+A+
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCL---LRNGALVDARAREEQTPLHIASR 506
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G ++LLL A P +G PL ++ ++G ++ A VL + T+ G
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Score = 60.5 bits (145), Expect = 5e-09
Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA + +G +H+A+ + ++ L L +GG +A++ + LTPLH AA
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL---LDRGGQIDAKTRDGLTPLHCAAR 308
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + +ELLL +GA R ++GL PL +A Q H+EC + L
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/120 (29%), Positives = 62/120 (51%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V E L+ G D N ++G A+HLAA H + + LL +G ++ + + T LH+
Sbjct: 47 VVEYLKGGIDINTCNQNGLNALHLAAKEGH---VGLVQELLGRGSSVDSATKKGNTALHI 103
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
A+ G +++L+ +GA+ + Q+G PL +A Q+ H++ + L + T T G
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Score = 53.1 bits (126), Expect = 7e-07
Identities = 36/106 (33%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ A + V D A+H+AA H R + L L + +PNAR++ TPLH+
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFTPLHI 404
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A + +ELL+ GA + GL P+ +A GHL +L
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 53.1 bits (126), Expect = 7e-07
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA P+ ++G +H+AA ++ LL G + N + + +TPLH+A+
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQ---MQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G + LLL +GA+ + + GL L LA Q+ + A +L T++G
Sbjct: 672 EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
++G +H+AA H + LL +G P+A + TPLH+AA + LL+
Sbjct: 594 KNGLTPLHVAA---HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
GA+ + + G+ PL LA Q+GH + +L D T+ G
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA+ ++ + G ++HLAA + L + G D +A + TPL VA
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAA---QEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
+G + + LL QGA+ + ++G PL A QQGH VL + T G
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Score = 50.8 bits (120), Expect = 4e-06
Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 34 NLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLE 93
N E G +H+AA H + LL +G + + +TPLHVA+ G ++
Sbjct: 227 NRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 94 LLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
LLL +G + +DGL PL A + GH + +L + RT+ G
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Score = 50.8 bits (120), Expect = 4e-06
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L + RE + LL GA +L + G +H+AA L LL++ +
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG---SLDVAKLLLQRRAAAD 590
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLHVAA + ++ LLL +GA P ++G PL +A ++ ++ A L +
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 131 LDTRTRTRTRIG 142
T T+ G
Sbjct: 651 YGAETNIVTKQG 662
Score = 50.4 bits (119), Expect = 5e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R VE LL GA ++G + +H+AA H + C+ LL+ +
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH---VECVKHLLQHKAPVD 359
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
+++ LT LHVAA G R +LLL + A+P R +G PL +A ++ ++ +L
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/118 (28%), Positives = 55/118 (46%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E L++ GA + E G +H+AA H L + LL+ G P+
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH---LNIVLLLLQNGASPD 458
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
++ T LH+AA G + LL GA R ++ PL +A + G E ++L
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 3/126 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E++ + L + GAD + + G + +A H ++ + LL+QG + NA++
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC---HYGNVKMVNFLLKQGANVNAKT 758
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPLH AA G + +LL GA P +G L +A + G++ L+ +
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818
Query: 134 RTRTRT 139
T T
Sbjct: 819 EVTTTT 824
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL A+PN +G +H+A ++ + L++ G A + LTP+HVAA
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNR---IKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + LLL GA P + + G L +A + G +E R L
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 65.1 bits (157), Expect = 2e-10
Identities = 40/125 (32%), Positives = 68/125 (54%), Gaps = 3/125 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V+ELL G+ + + G A+H+A+ A ++ L+++G + NA+S
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK---VLVKEGANINAQS 127
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPL++AA ++ LL GA+ + +DG PL +ALQQGH + +L + DT
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 134 RTRTR 138
+ + R
Sbjct: 188 KGKVR 192
Score = 61.6 bits (148), Expect = 2e-09
Identities = 40/117 (34%), Positives = 61/117 (52%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL+ GA P++ G A+H+AA A +RCL LR G +AR+ E TPLH+A+
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCL---LRNGALVDARAREEQTPLHIASR 506
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G ++LLL A P +G PL ++ ++G ++ A VL + T+ G
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Score = 60.5 bits (145), Expect = 5e-09
Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA + +G +H+A+ + ++ L L +GG +A++ + LTPLH AA
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL---LDRGGQIDAKTRDGLTPLHCAAR 308
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + +ELLL +GA R ++GL PL +A Q H+EC + L
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/120 (29%), Positives = 62/120 (51%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V E L+ G D N ++G A+HLAA H + + LL +G ++ + + T LH+
Sbjct: 47 VVEYLKGGIDINTCNQNGLNALHLAAKEGH---VGLVQELLGRGSSVDSATKKGNTALHI 103
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
A+ G +++L+ +GA+ + Q+G PL +A Q+ H++ + L + T T G
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Score = 53.1 bits (126), Expect = 7e-07
Identities = 36/106 (33%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ A + V D A+H+AA H R + L L + +PNAR++ TPLH+
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL---LDKRANPNARALNGFTPLHI 404
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
A + +ELL+ GA + GL P+ +A GHL +L
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Score = 53.1 bits (126), Expect = 7e-07
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA P+ ++G +H+AA ++ LL G + N + + +TPLH+A+
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQ---MQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G + LLL +GA+ + + GL L LA Q+ + A +L T++G
Sbjct: 672 EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
++G +H+AA H + LL +G P+A + TPLH+AA + LL+
Sbjct: 594 KNGLTPLHVAA---HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
GA+ + + G+ PL LA Q+GH + +L D T+ G
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA+ ++ + G ++HLAA + L + G D +A + TPL VA
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAA---QEDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
+G + + LL QGA+ + ++G PL A QQGH VL + T G
Sbjct: 738 YGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Score = 50.8 bits (120), Expect = 4e-06
Identities = 33/109 (30%), Positives = 51/109 (46%), Gaps = 3/109 (2%)
Query: 34 NLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLE 93
N E G +H+AA H + LL +G + + +TPLHVA+ G ++
Sbjct: 227 NRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 94 LLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
LLL +G + +DGL PL A + GH + +L + RT+ G
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Score = 50.8 bits (120), Expect = 4e-06
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L + RE + LL GA +L + G +H+AA L LL++ +
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG---SLDVAKLLLQRRAAAD 590
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ LTPLHVAA + ++ LLL +GA P ++G PL +A ++ ++ A L +
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650
Query: 131 LDTRTRTRTRIG 142
T T+ G
Sbjct: 651 YGAETNIVTKQG 662
Score = 50.4 bits (119), Expect = 5e-06
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R VE LL GA ++G + +H+AA H + C+ LL+ +
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH---VECVKHLLQHKAPVD 359
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
+++ LT LHVAA G R +LLL + A+P R +G PL +A ++ ++ +L
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/118 (28%), Positives = 55/118 (46%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E L++ GA + E G +H+AA H L + LL+ G P+
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH---LNIVLLLLQNGASPD 458
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
++ T LH+AA G + LL GA R ++ PL +A + G E ++L
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 3/126 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E++ + L + GAD + + G + +A H ++ + LL+QG + NA++
Sbjct: 702 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVAC---HYGNVKMVNFLLKQGANVNAKT 758
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPLH AA G + +LL GA P +G L +A + G++ L+ +
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE 818
Query: 134 RTRTRT 139
T T
Sbjct: 819 EVTTTT 824
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL A+PN +G +H+A ++ + L++ G A + LTP+HVAA
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNR---IKVMELLVKYGASIQAITESGLTPIHVAAF 440
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + LLL GA P + + G L +A + G +E R L
Sbjct: 441 MGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 63.9 bits (154), Expect = 4e-10
Identities = 41/125 (32%), Positives = 66/125 (52%), Gaps = 3/125 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V ELL+ A+ + + G A+H+A+ A ++ L+ G + NA+S
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK---VLVTNGANVNAQS 137
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPL++AA ++ LL GA +L +DG PL +ALQQGH + +L + DT
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT 197
Query: 134 RTRTR 138
+ + R
Sbjct: 198 KGKVR 202
Score = 59.3 bits (142), Expect = 1e-08
Identities = 38/120 (31%), Positives = 58/120 (48%), Gaps = 3/120 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V +L+ GA PN G A+H+AA + +R L ++ G A++ + TPLH+
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL---VQDGAQVEAKAKDDQTPLHI 505
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
+A G ++ LL QGA P G PL L+ ++GH + A L D T+ G
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565
Score = 56.2 bits (134), Expect = 9e-08
Identities = 37/117 (31%), Positives = 56/117 (47%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GAD N V G A+VHLAA H + + LL + + N + LTPLH+AA
Sbjct: 650 LLEYGADANAVTRQGIASVHLAAQEGH---VDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
E+L++QGA + + G PL + G+++ L + +T+ G
Sbjct: 707 EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNG 763
Score = 55.5 bits (132), Expect = 1e-07
Identities = 42/150 (28%), Positives = 62/150 (41%), Gaps = 30/150 (20%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHP------------------RG--------- 55
V++LL+ GA PN G +HL+A H +G
Sbjct: 515 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 574
Query: 56 ---LRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRP 112
L LL++ P+A LTPLHVAA + ++ LLL QGA P ++G P
Sbjct: 575 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634
Query: 113 LDLALQQGHLECARVLQDLDTRTRTRTRIG 142
L +A ++ ++ A L + TR G
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Score = 55.1 bits (131), Expect = 2e-07
Identities = 31/106 (29%), Positives = 60/106 (56%), Gaps = 3/106 (2%)
Query: 25 ELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAA 84
+ ++ G D N+ ++G A+HLA+ H + + LL++ + +A + + T LH+A+
Sbjct: 59 DYIKNGVDINICNQNGLNALHLASKEGH---VEVVSELLQREANVDAATKKGNTALHIAS 115
Query: 85 AWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
G +++L++ GA+ + Q+G PL +A Q+ HLE + L D
Sbjct: 116 LAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/117 (30%), Positives = 58/117 (49%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GA P+ ++G +H+AA + LL G D NA + + + +H+AA
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQ---MDIATTLLEYGADANAVTRQGIASVHLAAQ 673
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G + LLL + A+ L ++ GL PL LA Q+ + A VL + +T++G
Sbjct: 674 EGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Score = 51.2 bits (121), Expect = 3e-06
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 4/123 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ + V D A+H+AA H + + LL + +PNA+++ TPLH+
Sbjct: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK---VLLDKKANPNAKALNGFTPLHI 406
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
A + +ELLL GA + GL P+ +A GH+ L T T +
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT-TNVR 465
Query: 143 AET 145
ET
Sbjct: 466 GET 468
Score = 50.1 bits (118), Expect = 6e-06
Identities = 36/132 (27%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R+++ A LL+ + ++ + G +H+AA H + LL + +
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAA---HYGNINVATLLLNRAAAVD 262
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ +TPLHVA+ G ++LLL +GA + +DGL PL + GH + +L D
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322
Query: 131 LDTRTRTRTRIG 142
++T+ G
Sbjct: 323 RAAPILSKTKNG 334
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A ++ +E LL+ GA V E G +H+AA H + + L+ G PN
Sbjct: 404 LHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH---VNIVSQLMHHGASPN 460
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
+V T LH+AA G + L+ GA + +D PL ++ + G + + L
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Score = 48.5 bits (114), Expect = 2e-05
Identities = 25/67 (37%), Positives = 40/67 (59%)
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
LL +G +A++ + LTPLH A G + +E+LL + A + ++GL PL +A Q H
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
Query: 122 LECARVL 128
L C ++L
Sbjct: 347 LNCVQLL 353
Score = 43.5 bits (101), Expect = 6e-04
Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 3/103 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL A+PN +G +H+A ++ + LL+ G A + LTP+HVAA
Sbjct: 386 LLDKKANPNAKALNGFTPLHIACKKNR---IKVMELLLKHGASIQAVTESGLTPIHVAAF 442
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
G + L+ GA P + G L +A + G E R L
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 43.1 bits (100), Expect = 7e-04
Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 3/128 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E+ E L+ GA + + G +H+ H ++ + LL+ NA++
Sbjct: 704 AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGC---HYGNIKIVNFLLQHSAKVNAKT 760
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPLH AA G + +LL A P +G L +A + G++ L+ +
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTE 820
Query: 134 RTRTRTRI 141
T T T +
Sbjct: 821 ETMTTTTV 828
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/131 (26%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Query: 5 ARLARRLRDAL-------REEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLR 57
A++ + RD L R VE LL A ++G + +H+A H L
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH---LN 348
Query: 58 CLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLAL 117
C+ LL+ + + + LT LHVAA G + ++LL + A+P + +G PL +A
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
Query: 118 QQGHLECARVL 128
++ ++ +L
Sbjct: 409 KKNRIKVMELL 419
Score = 34.7 bits (78), Expect = 0.27
Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 7/115 (6%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A +E V+ LL GA +L EDG + +A H + + LL R
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQ---VVSLLLENDTKGKVR- 202
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
L LH+AA + LLL + + + G PL +A G++ A +L
Sbjct: 203 ---LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL 254
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 63.2 bits (152), Expect = 7e-10
Identities = 110/413 (26%), Positives = 153/413 (37%), Gaps = 72/413 (17%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
VEEL+ AD N V E G +A+H AA + + ALL+ G + + + + TPL +
Sbjct: 1922 VEELIASHADVNAVDELGKSALHWAAAVNN---VEATLALLKNGANKDMQDSKEETPLFL 1978
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G +LLL A+ + D P D+A ++ H + R+ LD + R+ G
Sbjct: 1979 AAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRL---LDQPSGPRSPPG 2035
Query: 143 AETQEP---EPAPGTPGLSGPTDETLDS------IALQKQPCRGDNRDIGLEADPGP-PS 192
P P PGL + S L Q RG + + L A PGP
Sbjct: 2036 PHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTL-ACPGPLAD 2094
Query: 193 LPVPLETVDK------HGSSASPPGHWDYSSDASFVTAVEVS------------------ 228
V L VD G + PG + + TA VS
Sbjct: 2095 SSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPG 2154
Query: 229 ------GAEDPASDTPPWAGSLPPTRQG---LLHVVHANQRVPRSQGTEAELNARLQALT 279
G +P + WA PP G LL + Q + + GT R
Sbjct: 2155 GCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLL--NPGTPVSPQERPPPYL 2212
Query: 280 LTPPN-----AAGFQSSPSSMPLLDRSPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATL 334
P + AAG SSP L R P+ P TP+P + EH S +
Sbjct: 2213 AVPGHGEEYPAAGAHSSPPKARFL-RVPSEHPYLTPSPESP------EHWASPSPPSLSD 2265
Query: 335 W--LTEDEASSTGGREPVG---PCRHLPVSTVSDLELLKGLRALGENPHPITP 382
W T A++TG P + LP+S S L + LG P +TP
Sbjct: 2266 WSESTPSPATATGAMATTTGALPAQPLPLSVPS--SLAQAQTQLGPQPE-VTP 2315
Score = 31.6 bits (70), Expect = 2.2
Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 6/79 (7%)
Query: 40 GAAAVHLAAG-ARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLL-S 97
G A+HLAA AR R L A G D NA+ TPLH A + ++L+ +
Sbjct: 1839 GETALHLAARYARADAAKRLLDA----GADTNAQDHSGRTPLHTAVTADAQGVFQILIRN 1894
Query: 98 QGADPALRDQDGLRPLDLA 116
+ D R DG L LA
Sbjct: 1895 RSTDLDARMADGSTALILA 1913
Score = 29.6 bits (65), Expect = 8.5
Identities = 30/102 (29%), Positives = 41/102 (40%), Gaps = 14/102 (13%)
Query: 30 GADPNLVLEDGAAAVHLAA---GARHPR----------GLRCLGALLRQGGDPNARSVEA 76
G D N+ DG + LA+ GA P + L+ QG AR+
Sbjct: 1779 GMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRT 1838
Query: 77 -LTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLAL 117
T LH+AA + + LL GAD +D G PL A+
Sbjct: 1839 GETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAV 1880
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 62.8 bits (151), Expect = 9e-10
Identities = 65/213 (30%), Positives = 87/213 (40%), Gaps = 43/213 (20%)
Query: 29 CGADPNLVLEDGAAAVHLAAG-------------------ARHPRGLRCLGALLRQG--- 66
CGAD +L DG +A+H AA AR G L R G
Sbjct: 194 CGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTP 253
Query: 67 --------GDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQ 118
G P R TPLH AA G + L+S DP+LRD+DG DLA
Sbjct: 254 ILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEY 313
Query: 119 QGHLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGD 178
GH +CA+ L+++ T P P P P L+ T +L+ + P G+
Sbjct: 314 HGHRDCAQYLREVAQPVPL-----LMTPPPPPFPPPPLLA--TRRSLED-GRRGGPGPGN 365
Query: 179 NRDIGLE-ADPGPPSLPVPLETVDKHGSSASPP 210
+ L A PG P P+P E + +S +PP
Sbjct: 366 PSPMSLSPAWPGHPDQPLPREQM----TSPAPP 394
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/112 (36%), Positives = 56/112 (50%), Gaps = 8/112 (7%)
Query: 14 ALREEEPWAVEELLRCGA-DPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDP-NA 71
A ++ + +E LL GA P + GA VH A A H L C+ L+++ P N
Sbjct: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGH---LDCVKFLVQRAQLPGNQ 65
Query: 72 RSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQD--GLRPLDLALQQGH 121
R+ TP H AAA G L L+ +G L+DQD G+ PL LA + GH
Sbjct: 66 RAHNGATPAHDAAATGSLAELCWLVREGG-CGLQDQDASGVSPLHLAARFGH 116
Score = 44.3 bits (103), Expect = 3e-04
Identities = 33/90 (36%), Positives = 44/90 (48%), Gaps = 4/90 (4%)
Query: 40 GAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS-Q 98
G + +HLAA HP + L L +G + E PLH AA G L+LL +
Sbjct: 104 GVSPLHLAARFGHPVLVEWL---LHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAH 160
Query: 99 GADPALRDQDGLRPLDLALQQGHLECARVL 128
G+ R + G PL LA Q+GHL A+ L
Sbjct: 161 GSSVNRRTRSGASPLYLACQEGHLHLAQFL 190
Score = 43.9 bits (102), Expect = 4e-04
Identities = 39/110 (35%), Positives = 53/110 (48%), Gaps = 11/110 (10%)
Query: 39 DGAAAVHLAAGARHPRGLRCLGALLRQGG----DPNARSVEALTPLHVAAAWGCRRGLEL 94
+GA H AA L L L+R+GG D +A V +PLH+AA +G +E
Sbjct: 69 NGATPAHDAAATG---SLAELCWLVREGGCGLQDQDASGV---SPLHLAARFGHPVLVEW 122
Query: 95 LLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDL-DTRTRTRTRIGA 143
LL +G L ++G RPL A G L C ++L + RTR GA
Sbjct: 123 LLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGA 172
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 62.4 bits (150), Expect = 1e-09
Identities = 41/117 (35%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A+ ++ + LL GAD V G A+H+A A H L LL+ G + N +
Sbjct: 108 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGH---LEAADVLLQHGANVNIQD 164
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
TPLH+AA +G + LLL GAD + + G RPL LA +G L A++L +
Sbjct: 165 AVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 221
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/113 (30%), Positives = 52/113 (46%), Gaps = 5/113 (4%)
Query: 22 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLH 81
A + LL+ GA+ N+ +H+AA H + R L L+ G D N PLH
Sbjct: 149 AADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL---LKFGADVNVSGEVGDRPLH 205
Query: 82 VAAAWGCRRGLELLLSQG--ADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
+A+A G +LL+ +G AD +D + PL + GH + + L D
Sbjct: 206 LASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 258
Score = 33.5 bits (75), Expect = 0.59
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 13/128 (10%)
Query: 10 RLRDALREEEPWAVEELLRCGADP-------NLVLEDGAAAVHLAA--GARHPRGLRCLG 60
RL D L+ +E E G+D N E+G + +HL G + +
Sbjct: 30 RLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSH----IR 85
Query: 61 ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
L+ +G P+ + T LH+A + LL GAD GL L +A G
Sbjct: 86 TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAG 145
Query: 121 HLECARVL 128
HLE A VL
Sbjct: 146 HLEAADVL 153
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 62.4 bits (150), Expect = 1e-09
Identities = 41/117 (35%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A+ ++ + LL GAD V G A+H+A A H L LL+ G + N +
Sbjct: 209 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGH---LEAADVLLQHGANVNIQD 265
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
TPLH+AA +G + LLL GAD + + G RPL LA +G L A++L +
Sbjct: 266 AVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 322
Score = 39.7 bits (91), Expect = 0.008
Identities = 34/113 (30%), Positives = 52/113 (46%), Gaps = 5/113 (4%)
Query: 22 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLH 81
A + LL+ GA+ N+ +H+AA H + R L L+ G D N PLH
Sbjct: 250 AADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL---LKFGADVNVSGEVGDRPLH 306
Query: 82 VAAAWGCRRGLELLLSQG--ADPALRDQDGLRPLDLALQQGHLECARVLQDLD 132
+A+A G +LL+ +G AD +D + PL + GH + + L D
Sbjct: 307 LASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD 359
Score = 33.5 bits (75), Expect = 0.59
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 13/128 (10%)
Query: 10 RLRDALREEEPWAVEELLRCGADP-------NLVLEDGAAAVHLAA--GARHPRGLRCLG 60
RL D L+ +E E G+D N E+G + +HL G + +
Sbjct: 131 RLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSH----IR 186
Query: 61 ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
L+ +G P+ + T LH+A + LL GAD GL L +A G
Sbjct: 187 TLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAG 246
Query: 121 HLECARVL 128
HLE A VL
Sbjct: 247 HLEAADVL 254
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/138 (33%), Positives = 62/138 (44%), Gaps = 3/138 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
VEEL+ AD + G A+H AA + R R +LL+ G D +A+ TPL +
Sbjct: 1717 VEELIAAQADVGARDKWGKTALHWAAAVNNARAAR---SLLQAGADKDAQDNREQTPLFL 1773
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
AA G +LLL GA LRDQ GL P D+A Q+ H + +L+
Sbjct: 1774 AAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATP 1833
Query: 143 AETQEPEPAPGTPGLSGP 160
P P T +S P
Sbjct: 1834 GREAGPFPRARTVSVSVP 1851
Score = 39.7 bits (91), Expect = 0.008
Identities = 37/117 (31%), Positives = 50/117 (42%), Gaps = 6/117 (5%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVH--LAAGARHPRGLRCLGALLRQGGDPNA 71
A R P A LL GA+PN G +H +AA AR C L + +A
Sbjct: 1641 AARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREV----CQLLLRSRQTAVDA 1696
Query: 72 RSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
R+ + TPL +AA +E L++ AD RD+ G L A + AR L
Sbjct: 1697 RTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSL 1753
Score = 36.6 bits (83), Expect = 0.070
Identities = 29/83 (34%), Positives = 37/83 (44%), Gaps = 2/83 (2%)
Query: 62 LLRQGGDPNARSV-EALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
LL G P A +V TPLH+AA + LL GA+P D+ G PL A+
Sbjct: 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAAD 1678
Query: 121 HLE-CARVLQDLDTRTRTRTRIG 142
E C +L+ T RT G
Sbjct: 1679 AREVCQLLLRSRQTAVDARTEDG 1701
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 61.6 bits (148), Expect = 2e-09
Identities = 42/121 (34%), Positives = 63/121 (52%), Gaps = 5/121 (4%)
Query: 10 RLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQ--GG 67
R R+ +E +E LL+ A+P++ ++G ++H AA H + CL LL + G
Sbjct: 477 RARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQ---CLELLLERTNSG 533
Query: 68 DPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARV 127
+ S +PLH+AA G + LE+LL D +RD+ G LDLA +GH EC
Sbjct: 534 FEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEA 593
Query: 128 L 128
L
Sbjct: 594 L 594
Score = 57.8 bits (138), Expect = 3e-08
Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V EL+ GA+ N +G +H AA + H G CL L+ G D N +S + +PLH+
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFAAASTH--GALCLELLVNNGADVNIQSKDGKSPLHM 287
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
A G + L+ G + D+DG PL +A + GH
Sbjct: 288 TAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH 326
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/106 (34%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
+E L+ GAD N+ +DG + +H+ A H R R L++ GG+ + + TPLHV
Sbjct: 264 LELLVNNGADVNIQSKDGKSPLHMTAV--HGRFTRSQ-TLIQNGGEIDCVDKDGNTPLHV 320
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA +G + L + GAD A + PL LA H +C R L
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/143 (28%), Positives = 56/143 (39%), Gaps = 31/143 (21%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGA-------------------------RHPRGLR 57
+E L+ GA+ N + G A+H AA + +
Sbjct: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
Query: 58 CLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGL--RPLDL 115
CL LL+ +P+ R E +H AAA+G R+ LELLL + G PL L
Sbjct: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
Query: 116 ALQQGHLECARV----LQDLDTR 134
A GH + V L DLD R
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIR 571
Score = 43.5 bits (101), Expect = 6e-04
Identities = 31/94 (32%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
+ G + AA A H + CL LLR NA T L +AA G +++L++
Sbjct: 812 DKGRTPLRAAAFADH---VECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Query: 98 QG-ADPALRDQDGLRPLDLALQQGHLECARVLQD 130
AD ++D+D PL LA +GH +CA ++ D
Sbjct: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 39.7 bits (91), Expect = 0.008
Identities = 30/106 (28%), Positives = 47/106 (44%), Gaps = 3/106 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
+E L+ GA N +H A +R ++ L++ D NAR TPLHV
Sbjct: 32 IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQ---VLIKHSADVNARDKNWQTPLHV 88
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AAA + E+++ + + D+ G L A GH+E +L
Sbjct: 89 AAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Score = 39.7 bits (91), Expect = 0.008
Identities = 25/81 (30%), Positives = 38/81 (46%)
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
L+ G NA+ LTPLH A A +++L+ AD RD++ PL +A
Sbjct: 35 LILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKA 94
Query: 122 LECARVLQDLDTRTRTRTRIG 142
++CA V+ L + R G
Sbjct: 95 VKCAEVIIPLLSSVNVSDRGG 115
Score = 39.7 bits (91), Expect = 0.008
Identities = 37/118 (31%), Positives = 45/118 (38%), Gaps = 3/118 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A R + L GAD +HLAA H C LL G + +
Sbjct: 318 LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD---CCRKLLSSGFEID 374
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
T LH AAA G ++LL S GAD +D+ G PL A H C L
Sbjct: 375 TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Score = 38.9 bits (89), Expect = 0.014
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A R EE AV+ L++ AD N ++ +H+AA + ++C ++ N
Sbjct: 58 ASRSEE--AVQVLIKHSADVNARDKNWQTPLHVAAANK---AVKCAEVIIPLLSSVNVSD 112
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
T LH AA G + LLL++GA+ D+ R L A GHL+ +L
Sbjct: 113 RGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Score = 38.5 bits (88), Expect = 0.018
Identities = 28/92 (30%), Positives = 43/92 (46%), Gaps = 3/92 (3%)
Query: 40 GAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQG 99
G A+H AA H + + LL +G + NA + LH AA G + LL++ G
Sbjct: 115 GRTALHHAALNGH---VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG 171
Query: 100 ADPALRDQDGLRPLDLALQQGHLECARVLQDL 131
A+ +D+ G PL A G + + L +L
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
Score = 37.4 bits (85), Expect = 0.041
Identities = 25/67 (37%), Positives = 32/67 (47%)
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
L+ + D N E TPLHVAA G +ELL+ GA +D L PL A+
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 122 LECARVL 128
E +VL
Sbjct: 62 EEAVQVL 68
Score = 37.4 bits (85), Expect = 0.041
Identities = 35/110 (31%), Positives = 42/110 (38%), Gaps = 6/110 (5%)
Query: 22 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLH 81
AV LL A+ + V G A+H H C+ LL Q + TPLH
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEE---CVQMLLEQEVSILCKDSRGRTPLH 716
Query: 82 VAAAWGCRRGLELLLSQG---ADPALRDQDGLRPLDLALQQGHLECARVL 128
AAA G L LL D +D G PL A G+ C VL
Sbjct: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Score = 35.4 bits (80), Expect = 0.16
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 3/74 (4%)
Query: 58 CLGALLRQGGDPNA---RSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLD 114
CL LL +P A + + TPL +A A+G + LLL + A+ D G L
Sbjct: 624 CLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALH 683
Query: 115 LALQQGHLECARVL 128
+ GH EC ++L
Sbjct: 684 RGIMTGHEECVQML 697
Score = 31.6 bits (70), Expect = 2.2
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA+ N + A+H AA H L + L+ G + + + TPLH
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGH---LDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 83 AAAWGCRRGLELLLSQGAD 101
AA+ G ++ LL+ G +
Sbjct: 188 AASNGQINVVKHLLNLGVE 206
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/105 (39%), Positives = 57/105 (54%), Gaps = 4/105 (3%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GAD N EDG+ A+HLA + P+ C+ LL+ G + +A E +PLH AA+
Sbjct: 73 LLANGADINSKNEDGSTALHLATISCQPQ---CVKVLLQHGANEDAVDAENRSPLHWAAS 129
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLE-CARVLQ 129
GC + LL A + D DG PL +A GH C+++LQ
Sbjct: 130 SGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQ 174
Score = 40.8 bits (94), Expect = 0.004
Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 5/104 (4%)
Query: 28 RCGADPNLVLEDGAAAVHLAAGARHPRGL-RCLGALLRQGGDPNARSVEALTPLHVAAAW 86
R A P + +G + HLAA +GL CL LL G D N+++ + T LH+A
Sbjct: 42 RKSARPTKLDSNGQSPFHLAAS----KGLTECLTILLANGADINSKNEDGSTALHLATIS 97
Query: 87 GCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
+ +++LL GA+ D + PL A G +L D
Sbjct: 98 CQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCD 141
Score = 33.5 bits (75), Expect = 0.59
Identities = 43/174 (24%), Positives = 62/174 (35%), Gaps = 37/174 (21%)
Query: 19 EPWAVEELLRCGADPNLVLEDGAAAVHLAAGA-----------------------RHPRG 55
+P V+ LL+ GA+ + V + + +H AA + R P
Sbjct: 99 QPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLM 158
Query: 56 LRCLGA-------LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQD 108
+ LG LL++G N + L +A G ELLLS GAD D
Sbjct: 159 IASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDST 218
Query: 109 GLRPLDLALQQGHLECARVLQDLDTRTR-------TRTRIGAETQEPEPAPGTP 155
G L AL R LQ +R R + ++ EP G+P
Sbjct: 219 GHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHPDLASQASPSEPQAGSP 272
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 61.2 bits (147), Expect = 3e-09
Identities = 44/132 (33%), Positives = 63/132 (47%), Gaps = 9/132 (6%)
Query: 4 EARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALL 63
E +RLRD+ + V++LL GADP + G A+H A+ + + ++ L L
Sbjct: 107 EVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL---L 163
Query: 64 RQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA------L 117
G DPN R TPLH+AA + LL GA D+ G PL LA L
Sbjct: 164 DHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNIL 223
Query: 118 QQGHLECARVLQ 129
Q+GH +C ++
Sbjct: 224 QEGHAQCLEAVR 235
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/134 (32%), Positives = 54/134 (40%), Gaps = 6/134 (4%)
Query: 12 RDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGAR---HPRGLRCLGALLRQGGD 68
RD LR + P LR A P+ L VH R + + + LL G D
Sbjct: 79 RDELRCKIPAG---RLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGAD 135
Query: 69 PNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
P A + T LH A+ G + ++LLL GADP RD G PL LA H+ L
Sbjct: 136 PCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTL 195
Query: 129 QDLDTRTRTRTRIG 142
R R G
Sbjct: 196 LRGGARVDALDRAG 209
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 60.8 bits (146), Expect = 3e-09
Identities = 48/139 (34%), Positives = 66/139 (47%), Gaps = 7/139 (5%)
Query: 2 CSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGA 61
C A L A ++++P LL GAD N V EDG A +H AA R L
Sbjct: 390 CQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL-- 447
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
L G +A+ E TPLH+AA LL+S+ ADP L + +G PL +A GH
Sbjct: 448 -LDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGH 506
Query: 122 LECARVL----QDLDTRTR 136
+ ++L +LD + R
Sbjct: 507 VSLVKLLTSQGAELDAQQR 525
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 3/105 (2%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
A R E V LL+CGADPN + G +HLA + L + LL + +AR+
Sbjct: 633 AARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA--VQRSTFLSVIN-LLEHHANVHARN 689
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQ 118
TP H+AA G L++L+ GA ++D PL LAL+
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
Score = 50.4 bits (119), Expect = 5e-06
Identities = 38/117 (32%), Positives = 49/117 (41%), Gaps = 3/117 (2%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LLR GA L G +HLAA H L + L + A TPLH+AA
Sbjct: 579 LLRYGASLELPTHQGWTPLHLAAYKGH---LEIIHLLAESHANMGALGAVNWTPLHLAAR 635
Query: 86 WGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
G + LL GADP +Q G PL LA+Q+ L + R ++G
Sbjct: 636 HGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG 692
Score = 47.0 bits (110), Expect = 5e-05
Identities = 40/130 (30%), Positives = 52/130 (40%), Gaps = 30/130 (23%)
Query: 31 ADPNLVLEDGAAAVHLAAGARH-----------------------------PRG-LRCLG 60
ADPNL +G +H+AA H RG +R +
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544
Query: 61 ALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
LL+ G P+A PLH AAA G ++LL GA L G PL LA +G
Sbjct: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
Query: 121 HLECARVLQD 130
HLE +L +
Sbjct: 605 HLEIIHLLAE 614
Score = 38.9 bits (89), Expect = 0.014
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 44 VHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPA 103
+HLAA RH + ALL+ G DPNA TPLH+A + LL A+
Sbjct: 630 LHLAA--RHGEEA-VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 104 LRDQDGLRPLDLALQQGHLECARVL 128
R++ G P LA +G+ +VL
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVL 711
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 60.8 bits (146), Expect = 3e-09
Identities = 36/99 (36%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V EL+ CGA N E G +H AA + H G CL L+ G D N +S + TPLH+
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTH--GALCLELLVGNGADVNMKSKDGKTPLHM 312
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
A G + ++ GA D++G PL +A + GH
Sbjct: 313 TALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/115 (33%), Positives = 60/115 (52%), Gaps = 9/115 (7%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGA------LLRQGGDP---NARS 73
+E LLR A+P + + G AVH +A H L+ + + L+ G ++ +
Sbjct: 488 LEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDN 547
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
++PLH+AA G + LE+L+ D +R+ G PLDLA +GH+EC VL
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 4/104 (3%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
LL GAD N + G + +H AA + +CL AL+ G N TPLH AA
Sbjct: 424 LLNTGADFNKKDKFGRSPLHYAAANCN---YQCLFALVGSGASVNDLDERGCTPLHYAAT 480
Query: 86 WGC-RRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
+ LE LL A+P +RD+ G + + GH C +++
Sbjct: 481 SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Score = 47.0 bits (110), Expect = 5e-05
Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V LL GA+ + + G A+H A H C+ ALL+ G R TP+H+
Sbjct: 669 VYSLLNKGANVDAKDKWGRTALHRGAVTGHEE---CVDALLQHGAKCLLRDSRGRTPIHL 725
Query: 83 AAAWGCRRGLELLL----SQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRT 137
+AA G L LL S A+PA D G L A GH C +L + + +T
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKT 784
Score = 44.7 bits (104), Expect = 3e-04
Identities = 38/125 (30%), Positives = 54/125 (43%), Gaps = 18/125 (14%)
Query: 26 LLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAA 85
L+ GA N + E G +H AA + +CL LLR +P R + +H +AA
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDG--KCLEYLLRNDANPGIRDKQGYNAVHYSAA 514
Query: 86 WGCRRGLELLLSQGADPALRDQDG------------LRPLDLALQQGHLECARV----LQ 129
+G R L+L+ S+ L + G + PL LA GH + V L
Sbjct: 515 YGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL 574
Query: 130 DLDTR 134
DLD R
Sbjct: 575 DLDVR 579
Score = 44.3 bits (103), Expect = 3e-04
Identities = 36/132 (27%), Positives = 55/132 (41%), Gaps = 3/132 (2%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L A+ +P V L+ D N + +H AA + + L+ G N
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAA---YLGDAEIIELLILSGARVN 68
Query: 71 ARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
A+ + LTPLH A A +++LL AD RD++ PL +A ++CA L
Sbjct: 69 AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP 128
Query: 131 LDTRTRTRTRIG 142
L + R G
Sbjct: 129 LLSNVNVSDRAG 140
Score = 43.9 bits (102), Expect = 4e-04
Identities = 33/107 (30%), Positives = 53/107 (49%), Gaps = 3/107 (2%)
Query: 22 AVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLH 81
AV+ LL+ AD N ++ +H+AA + ++C AL+ + N T LH
Sbjct: 89 AVQVLLKHSADVNARDKNWQTPLHIAAANK---AVKCAEALVPLLSNVNVSDRAGRTALH 145
Query: 82 VAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
AA G ++LLLS+GA+ D+ R + A GH+E ++L
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/119 (26%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
+ +++ GA + ++G +H+AA H + L+ G D R + + PLH+A
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHEL---LINTLITSGADTAKRGIHGMFPLHLA 379
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIG 142
A G LLS G D D G L A G+LEC +L + + + G
Sbjct: 380 ALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Score = 40.4 bits (93), Expect = 0.005
Identities = 43/140 (30%), Positives = 54/140 (38%), Gaps = 10/140 (7%)
Query: 2 CSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGA 61
C + L A R + L+ GAD G +HLAA + C
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD---CCRK 390
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
LL G D + T LH AAA G L LLL+ GAD +D+ G PL A +
Sbjct: 391 LLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCN 450
Query: 122 LECARVL-------QDLDTR 134
+C L DLD R
Sbjct: 451 YQCLFALVGSGASVNDLDER 470
Score = 40.0 bits (92), Expect = 0.006
Identities = 22/65 (33%), Positives = 33/65 (50%)
Query: 58 CLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLAL 117
C+ +LL +G + +A+ T LH A G ++ LL GA LRD G P+ L+
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
Query: 118 QQGHL 122
GH+
Sbjct: 728 ACGHI 732
Score = 39.3 bits (90), Expect = 0.011
Identities = 30/86 (34%), Positives = 44/86 (51%), Gaps = 4/86 (4%)
Query: 44 VHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPA 103
+HLAA H + L L L D + R+ TPL +AA G +++L++QGA
Sbjct: 554 LHLAAYHGHHQALEVLVQSLL---DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 104 LRDQDGLR-PLDLALQQGHLECARVL 128
++D R P+ A GH EC R+L
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLL 636
Score = 39.3 bits (90), Expect = 0.011
Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 2/90 (2%)
Query: 25 ELLRCGADPNLVLEDGA--AAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
E+L A L L+D + A+HLA H + + NA + TPLHV
Sbjct: 873 EMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHV 932
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRP 112
AA G ++ LL +GA D++G P
Sbjct: 933 AARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 38.5 bits (88), Expect = 0.018
Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 4/127 (3%)
Query: 40 GAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQ- 98
G +H AA H + CL LL N+ TPL +AA G +E+L+S
Sbjct: 823 GRTPLHAAAFTDH---VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 879
Query: 99 GADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLS 158
A+ L+D L LA +GH A ++ + T A Q P GL+
Sbjct: 880 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 939
Query: 159 GPTDETL 165
E L
Sbjct: 940 MVVQELL 946
Score = 37.7 bits (86), Expect = 0.031
Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 3/98 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL GA+ N + A+H AA H + + L+ G + + ++ TPLH
Sbjct: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGH---IEVVKLLVSHGAEVTCKDKKSYTPLHA 212
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQG 120
AA+ G ++ LL G D + G PL +A G
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Score = 32.7 bits (73), Expect = 1.0
Identities = 21/59 (35%), Positives = 26/59 (44%)
Query: 70 NARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
NA + TPLH AA L+LLLS A D G PL +A + G +L
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 30.8 bits (68), Expect = 3.8
Identities = 34/139 (24%), Positives = 53/139 (38%), Gaps = 8/139 (5%)
Query: 44 VHLAAGARHPRGLRCLGALLRQGGDPNARSVE---ALTPLHVAAAWGCRRGLELLLSQGA 100
+H AA H CL L+ NA ++ TPL ++ G + LL++GA
Sbjct: 621 IHAAATNGHSE---CLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 101 DPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGP 160
+ +D+ G L GH EC L + R G A G G+ G
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 737
Query: 161 TDETLDSIALQKQPCRGDN 179
++ + ++ P DN
Sbjct: 738 LLQS--AASMDANPATADN 754
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/104 (41%), Positives = 52/104 (50%), Gaps = 4/104 (3%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L +A V LL GADPN+ +DG +HL G P L C LLR G +
Sbjct: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRG---PGTLECAELLLRFGARVD 253
Query: 71 ARS-VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPL 113
RS E TPLHVAA G +LLL +GA P R+ +G PL
Sbjct: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 297
Score = 57.4 bits (137), Expect = 4e-08
Identities = 42/115 (36%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
E+ +H+AA H LR L LR+ P++ + T LH A A G + +LL
Sbjct: 159 EELTTPLHVAASRGHTEVLRLL---LRRRARPDS-APGGRTALHEACAAGHTACVHVLLV 214
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAP 152
GADP + DQDG RPL L G LECA +L R R+ ++E E P
Sbjct: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELL------LRFGARVDGRSEEEEETP 263
Score = 39.7 bits (91), Expect = 0.008
Identities = 38/107 (35%), Positives = 46/107 (42%), Gaps = 18/107 (16%)
Query: 26 LLRCGADPNLVLEDGAAAVHLA----------AGARHPRGLRCLGALLRQGGDPNARSVE 75
LLR GA P+ +G + A A A R L+ LL G D +A +
Sbjct: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
Query: 76 ALTPLHVAAAWGCRRG----LELLLSQGADPALRDQDGLRPLDLALQ 118
PLH+A CRRG +ELLLS G D G PL ALQ
Sbjct: 339 KQRPLHLA----CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/104 (41%), Positives = 52/104 (50%), Gaps = 4/104 (3%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L +A V LL GADPN+ +DG +HL G P L C LLR G +
Sbjct: 197 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRG---PGTLECAELLLRFGARVD 253
Query: 71 ARS-VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPL 113
RS E TPLHVAA G +LLL +GA P R+ +G PL
Sbjct: 254 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 297
Score = 57.4 bits (137), Expect = 4e-08
Identities = 42/115 (36%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
E+ +H+AA H LR L LR+ P++ + T LH A A G + +LL
Sbjct: 159 EELTTPLHVAASRGHTEVLRLL---LRRRARPDS-APGGRTALHEACAAGHTACVHVLLV 214
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAP 152
GADP + DQDG RPL L G LECA +L R R+ ++E E P
Sbjct: 215 AGADPNIADQDGKRPLHLCRGPGTLECAELL------LRFGARVDGRSEEEEETP 263
Score = 39.7 bits (91), Expect = 0.008
Identities = 38/107 (35%), Positives = 46/107 (42%), Gaps = 18/107 (16%)
Query: 26 LLRCGADPNLVLEDGAAAVHLA----------AGARHPRGLRCLGALLRQGGDPNARSVE 75
LLR GA P+ +G + A A A R L+ LL G D +A +
Sbjct: 279 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 338
Query: 76 ALTPLHVAAAWGCRRG----LELLLSQGADPALRDQDGLRPLDLALQ 118
PLH+A CRRG +ELLLS G D G PL ALQ
Sbjct: 339 KQRPLHLA----CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 381
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/104 (41%), Positives = 52/104 (50%), Gaps = 4/104 (3%)
Query: 11 LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPN 70
L +A V LL GADPN+ +DG +HL G P L C LLR G +
Sbjct: 137 LHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRG---PGTLECAELLLRFGARVD 193
Query: 71 ARS-VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPL 113
RS E TPLHVAA G +LLL +GA P R+ +G PL
Sbjct: 194 GRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPL 237
Score = 57.4 bits (137), Expect = 4e-08
Identities = 42/115 (36%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
E+ +H+AA H LR L LR+ P++ + T LH A A G + +LL
Sbjct: 99 EELTTPLHVAASRGHTEVLRLL---LRRRARPDS-APGGRTALHEACAAGHTACVHVLLV 154
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAP 152
GADP + DQDG RPL L G LECA +L R R+ ++E E P
Sbjct: 155 AGADPNIADQDGKRPLHLCRGPGTLECAELL------LRFGARVDGRSEEEEETP 203
Score = 39.7 bits (91), Expect = 0.008
Identities = 38/107 (35%), Positives = 46/107 (42%), Gaps = 18/107 (16%)
Query: 26 LLRCGADPNLVLEDGAAAVHLA----------AGARHPRGLRCLGALLRQGGDPNARSVE 75
LLR GA P+ +G + A A A R L+ LL G D +A +
Sbjct: 219 LLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQD 278
Query: 76 ALTPLHVAAAWGCRRG----LELLLSQGADPALRDQDGLRPLDLALQ 118
PLH+A CRRG +ELLLS G D G PL ALQ
Sbjct: 279 KQRPLHLA----CRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQ 321
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 58.5 bits (140), Expect = 2e-08
Identities = 67/224 (29%), Positives = 93/224 (41%), Gaps = 24/224 (10%)
Query: 4 EARLARRLRDALREEEPWAVEELL----RCGADPNLVLE-----DGAAAVHLAAGARHPR 54
+A +ARR D E A EELL RC + + E GA+A+H+AA +
Sbjct: 184 KAEIARRGVDV--EAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIE 241
Query: 55 GLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLD 114
+R L L+ G DP R + TPLH AA WG LL G G RP D
Sbjct: 242 VMRLL---LQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCD 298
Query: 115 LALQQGHL---ECARVLQDLDTRTRTRTRIGAETQEPEPA----PGTPGLSGPTDETLDS 167
LA ++ E AR +DL + G E Q P + LS +L
Sbjct: 299 LADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQD 358
Query: 168 IALQKQPCRGDNRDIGLEADPGP--PSLPVPLETVDKHGSSASP 209
++ +++P I + D G P+ P P E +G S+ P
Sbjct: 359 LSKERRPGGAGGPPI-QDEDEGEEGPTEPPPAEPRTLNGVSSPP 401
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/78 (41%), Positives = 39/78 (50%), Gaps = 3/78 (3%)
Query: 39 DGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQ 98
DG +A+H A L + L+ QG N E TPLHVAA+ G LLS
Sbjct: 100 DGISALHQAC---IDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSH 156
Query: 99 GADPALRDQDGLRPLDLA 116
GA+ A + DG PLDLA
Sbjct: 157 GANIAAVNSDGDLPLDLA 174
Score = 32.3 bits (72), Expect = 1.3
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 6/75 (8%)
Query: 60 GALLRQGGDPNARSV------EALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPL 113
GA L P AR+V + ++ LH A + L+ QGA D +G PL
Sbjct: 79 GAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPL 138
Query: 114 DLALQQGHLECARVL 128
+A G+L+ AR L
Sbjct: 139 HVAASCGYLDIARYL 153
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 58.2 bits (139), Expect = 2e-08
Identities = 58/202 (28%), Positives = 84/202 (41%), Gaps = 33/202 (16%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
+DGA A+H AA H + L LL GG+ +A + TPLH AA G ++L+
Sbjct: 238 KDGATAMHFAASRGHTK---VLSWLLLHGGEISA-DLWGGTPLHDAAENGELECCQILVV 293
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVL---QDLDTRTRTRTR---IGAETQEPEPA 151
GA+ +RD+DG DL+ GH C R L ++L R +R E ++P+
Sbjct: 294 NGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELEAKQPDSG 353
Query: 152 PGTPG-----------LSGPTD--ETLDSIALQKQPCRGDNRDIGLEA----------DP 188
+P LS PT DS + +G + GL + D
Sbjct: 354 MSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQHPPCGLSSARAADIQSYMDM 413
Query: 189 GPPSLPVPLETVDKHGSSASPP 210
P L +P T+ K PP
Sbjct: 414 LNPELGLPRGTIGKPTPPPPPP 435
Score = 51.2 bits (121), Expect = 3e-06
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 40 GAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQG 99
GA +HLAA HP + L L GGDP A + P+H AAA G L LL+
Sbjct: 104 GATVLHLAARFGHPEVVNWL--LHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHY 161
Query: 100 ADPA-LRDQDGLRPLDLALQQGHLECARVL 128
+ + ++G PL LA Q+GHLE + L
Sbjct: 162 PEGVNAQTKNGATPLYLACQEGHLEVTQYL 191
Score = 49.3 bits (116), Expect = 1e-05
Identities = 39/110 (35%), Positives = 50/110 (45%), Gaps = 4/110 (3%)
Query: 14 ALREEEPWAVEELLRCGA-DPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNAR 72
A R P V LL G DP + GA +H AA LR L +G NA+
Sbjct: 111 AARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEG--VNAQ 168
Query: 73 SVEALTPLHVAAAWGCRRGLELLLSQ-GADPALRDQDGLRPLDLALQQGH 121
+ TPL++A G + L+ + GADP R DG+ PL A Q GH
Sbjct: 169 TKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGH 218
Score = 35.8 bits (81), Expect = 0.12
Identities = 33/85 (38%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 41 AAAVHLAAGARHPRGLRCLGALLRQGGDPNA-RSVEALTPLHVAAAWGCRRGLELLLSQG 99
A VH AA A L CL L+ + P A R+ TP H A+A G L+ LLSQG
Sbjct: 37 ALPVHHAARAGK---LHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQG 93
Query: 100 ADPAL-RDQDGLRPLDLALQQGHLE 123
+D G L LA + GH E
Sbjct: 94 GCRVQDKDNSGATVLHLAARFGHPE 118
Score = 32.7 bits (73), Expect = 1.0
Identities = 52/198 (26%), Positives = 62/198 (31%), Gaps = 24/198 (12%)
Query: 132 DTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRGDNRDIGLEADPGPP 191
+ R R R G P G S P L C D + E P PP
Sbjct: 542 EVRARQPARAGCPRLGPAARGSLEGPSAPPQAALLPGNHVPNGCAADPK-ASRELPPPPP 600
Query: 192 SLPVPLETVDKHGSSASP-------PGHWDYSSDASFVTAVEVSGAEDPASDTPPWAG-- 242
P PL A P PG S +S + + P D
Sbjct: 601 PPPPPLPEAASSPPPAPPLPLESAGPGCGQRRSSSS-TGSTKSFNMMSPTGDNSELLAEI 659
Query: 243 ----SLPPTRQ--GLLHVVHA-NQRVPRSQGTEAELNARLQALTLTPPNAAGFQSSPSSM 295
SL PT Q GL V Q + ++ L + P AAGFQ
Sbjct: 660 KAGKSLKPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQ------ 713
Query: 296 PLLDRSPAHSPPRTPTPG 313
PLL+ S PP TP PG
Sbjct: 714 PLLNGSLVPVPPTTPAPG 731
>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
Length = 420
Score = 57.4 bits (137), Expect = 4e-08
Identities = 39/108 (36%), Positives = 55/108 (50%), Gaps = 4/108 (3%)
Query: 25 ELLRCGADPNLVLEDGAAA-VHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
+L+R GA N+ A H+AA HP+ CL L++ G + N E TP+H A
Sbjct: 76 QLVRAGATLNVSTTRYAQTPAHIAAFGGHPQ---CLVWLIQAGANINKPDCEGETPIHKA 132
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDL 131
A G + L++ GA LR+ GL D+A QG ECA+ L +L
Sbjct: 133 ARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 57.0 bits (136), Expect = 5e-08
Identities = 39/94 (41%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
VE LL+ GA+ + + G +H A H + LL QG DPNAR TPLH
Sbjct: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAE---VVSLLLCQGADPNARDNWNYTPLHE 288
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 116
AA G +LL GADP +R+ DG LDLA
Sbjct: 289 AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/93 (39%), Positives = 48/93 (51%), Gaps = 3/93 (3%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL GAD N + G +H AA H + L++ NA A TPLH A
Sbjct: 854 EYLLEHGADVNAQDKGGLIPLHNAASYGH---VDIAALLIKYNTCVNATDKWAFTPLHEA 910
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 116
A G + LLL+ GADP +++Q+G PLDLA
Sbjct: 911 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 53.9 bits (128), Expect = 4e-07
Identities = 36/93 (38%), Positives = 45/93 (48%), Gaps = 3/93 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
VE LL GAD + + G +H A H L+R G N + TPLH
Sbjct: 700 VEYLLHHGADVHAKDKGGLVPLHNACSYGH---YEVAELLVRHGASVNVADLWKFTPLHE 756
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDL 115
AAA G +LLL GADP +++DG PLDL
Sbjct: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
Score = 51.2 bits (121), Expect = 3e-06
Identities = 39/121 (32%), Positives = 54/121 (44%), Gaps = 18/121 (14%)
Query: 26 LLRCGADPNLVLEDGAAAVHLA------------------AGARHPRGLRCLGALLRQGG 67
LL+ GADPN+ DG +A+ LA AR + + L
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
Query: 68 DPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARV 127
+ +A TPLH+AA + R ++LLL GAD +D+ GL PL A GH E +
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 128 L 128
L
Sbjct: 421 L 421
Score = 50.4 bits (119), Expect = 5e-06
Identities = 30/86 (34%), Positives = 44/86 (51%)
Query: 43 AVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADP 102
A+H A + HP+ + LLR+G + N ++ + +TPLHVAA +E+L GA
Sbjct: 525 ALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKM 584
Query: 103 ALRDQDGLRPLDLALQQGHLECARVL 128
D G L A GHL+ R+L
Sbjct: 585 NALDTLGQTALHRAALAGHLQTCRLL 610
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/67 (40%), Positives = 36/67 (53%)
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
LL+ G + +AR L PLH A ++G + LLL QGADP RD PL A +G
Sbjct: 235 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 294
Query: 122 LECARVL 128
++ VL
Sbjct: 295 IDVCIVL 301
Score = 43.9 bits (102), Expect = 4e-04
Identities = 33/94 (35%), Positives = 44/94 (46%), Gaps = 3/94 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GAD + + G +H A H LL+ G NA + TPLH
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGH---YEVTELLLKHGACVNAMDLWQFTPLHE 441
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 116
AA+ LLLS GADP L + G +D+A
Sbjct: 442 AASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 70 NARSVEAL--TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARV 127
N R +E TPLH AA + +E LL GAD +D+ GL PL A GH E A +
Sbjct: 676 NCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
Query: 128 L 128
L
Sbjct: 736 L 736
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 8/122 (6%)
Query: 12 RDALREEEPWAVEELLRCGADP---NLVLEDG--AAAVHLAAGARHPRGLRCLGALLRQG 66
+D L E EE L P N DG + +HLAAG +R + LL+ G
Sbjct: 336 KDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR---VRIVQLLLQHG 392
Query: 67 GDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECAR 126
D +A+ L PLH A ++G ELLL GA D PL A + +E
Sbjct: 393 ADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCS 452
Query: 127 VL 128
+L
Sbjct: 453 LL 454
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 78 TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQDLDT 133
TPLH+AA + E LL GAD +D+ GL PL A GH++ A +L +T
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT 894
Score = 40.4 bits (93), Expect = 0.005
Identities = 35/117 (29%), Positives = 51/117 (43%), Gaps = 7/117 (5%)
Query: 14 ALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARS 73
+L + E LLR GA+ N +D +H+AA H + L + G NA
Sbjct: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH---KHGAKMNALD 588
Query: 74 VEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVLQD 130
T LH AA G + LLLS G+DP++ G A Q G+ ++L +
Sbjct: 589 TLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGF----TAAQMGNEAVQQILSE 641
Score = 39.3 bits (90), Expect = 0.011
Identities = 22/51 (43%), Positives = 28/51 (54%)
Query: 78 TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
+PLH AA +G + +E LL GA+ RD GL PL A GH E +L
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLL 268
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/85 (31%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 44 VHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPA 103
+H AAG + + LL G D +A+ L PLH A ++G ELL+ GA
Sbjct: 688 LHFAAGYNR---VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744
Query: 104 LRDQDGLRPLDLALQQGHLECARVL 128
+ D PL A +G E ++L
Sbjct: 745 VADLWKFTPLHEAAAKGKYEICKLL 769
>gi|34304383 Usher syndrome 1G protein [Homo sapiens]
Length = 461
Score = 57.0 bits (136), Expect = 5e-08
Identities = 35/94 (37%), Positives = 49/94 (52%), Gaps = 3/94 (3%)
Query: 38 EDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLS 97
EDG AA + L L ++ +GGDP+ + TPLH+AA+ G L L+S
Sbjct: 30 EDGMTPTLWAA---YHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLVS 86
Query: 98 QGADPALRDQDGLRPLDLALQQGHLECARVLQDL 131
GA+ D D PLD+A +GH+EC R L +
Sbjct: 87 FGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSI 120
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/59 (40%), Positives = 29/59 (49%)
Query: 70 NARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
NA + +TP AA G L L++S+G DP D G PL LA GHL C L
Sbjct: 26 NAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFL 84
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 55.5 bits (132), Expect = 1e-07
Identities = 42/116 (36%), Positives = 56/116 (48%), Gaps = 6/116 (5%)
Query: 4 EARLARR--LRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGA 61
+AR+ R L +A + V LL GA N++ E+G +HL P L+C
Sbjct: 138 DARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCT---IPESLQCAKL 194
Query: 62 LLRQGGDPNARSVEAL-TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 116
LL G N + E+ TPLHVAAA G + + L L GAD LR G L+ A
Sbjct: 195 LLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTA 250
Score = 47.4 bits (111), Expect = 4e-05
Identities = 39/97 (40%), Positives = 45/97 (46%), Gaps = 5/97 (5%)
Query: 27 LRCGADPNLVLEDGAAAVHLA-AGARHPRGLRCLGA----LLRQGGDPNARSVEALTPLH 81
L GAD L G A++ A AGA P R A LL G D A + TPLH
Sbjct: 230 LEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLH 289
Query: 82 VAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQ 118
A A GC ELLL GA + + G P+D ALQ
Sbjct: 290 NACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
Score = 37.0 bits (84), Expect = 0.054
Identities = 39/148 (26%), Positives = 57/148 (38%), Gaps = 14/148 (9%)
Query: 58 CLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLAL 117
C L+RQG + +AR V LH A A + LLL+ GA + ++G PL L
Sbjct: 126 CARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCT 184
Query: 118 QQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGPTDETLDSIALQKQPCRG 177
L+CA++L L+ G + P GL +AL +
Sbjct: 185 IPESLQCAKLL--LEAGATVNLAAGESQETPLHVAAARGLE-------QHVALYLE---- 231
Query: 178 DNRDIGLEADPGPPSLPVPLETVDKHGS 205
D+GL G +L + GS
Sbjct: 232 HGADVGLRTSQGETALNTACAGAEGPGS 259
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/94 (40%), Positives = 47/94 (50%), Gaps = 3/94 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
VE LL+ GA+ + G +H A H + LLR G DPNAR TPLH
Sbjct: 74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAE---VVNLLLRHGADPNARDNWNYTPLHE 130
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 116
AA G +LL GA+P +R+ DG LDLA
Sbjct: 131 AAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 55.5 bits (132), Expect = 1e-07
Identities = 37/92 (40%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 24 EELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVA 83
E LL+ GAD N + G +H AA H + L++ NA A TPLH A
Sbjct: 696 EYLLQHGADVNAQDKGGLIPLHNAASYGH---VDVAALLIKYNACVNATDKWAFTPLHEA 752
Query: 84 AAWGCRRGLELLLSQGADPALRDQDGLRPLDL 115
A G + LLL+ GADP L++Q+G PLDL
Sbjct: 753 AQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
Score = 52.4 bits (124), Expect = 1e-06
Identities = 39/112 (34%), Positives = 51/112 (45%), Gaps = 3/112 (2%)
Query: 4 EARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALL 63
E R + L A VE LL+ GAD + + G +H A H L+
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGH---YEVAELLV 579
Query: 64 RQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDL 115
+ G N + TPLH AAA G +LLL GADP +++DG PLDL
Sbjct: 580 KHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
Score = 47.0 bits (110), Expect = 5e-05
Identities = 29/86 (33%), Positives = 45/86 (52%)
Query: 43 AVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADP 102
A+H AA + +P+ + LLR+G + N ++ E LTPLHVA+ +E+++ A
Sbjct: 367 ALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKV 426
Query: 103 ALRDQDGLRPLDLALQQGHLECARVL 128
D G L A GHL+ R+L
Sbjct: 427 NALDNLGQTSLHRAAYCGHLQTCRLL 452
Score = 43.5 bits (101), Expect = 6e-04
Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 70 NARSVEAL--TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARV 127
N R +E TPLH AA + +E LL GAD +D+ GL PL A GH E A +
Sbjct: 518 NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAEL 577
Query: 128 L 128
L
Sbjct: 578 L 578
Score = 43.1 bits (100), Expect = 7e-04
Identities = 26/67 (38%), Positives = 34/67 (50%)
Query: 62 LLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGH 121
LL+ G + AR L PLH A ++G + LLL GADP RD PL A +G
Sbjct: 77 LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGK 136
Query: 122 LECARVL 128
++ VL
Sbjct: 137 IDVCIVL 143
Score = 43.1 bits (100), Expect = 7e-04
Identities = 35/121 (28%), Positives = 51/121 (42%), Gaps = 18/121 (14%)
Query: 26 LLRCGADPNLVLEDGAAAVHLA------------------AGARHPRGLRCLGALLRQGG 67
LL+ GA+P + DG A+ LA AR + + L
Sbjct: 143 LLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNV 202
Query: 68 DPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARV 127
+ +A TPLH+AA + + ++LLL GAD +D+ L PL A GH E +
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
Query: 128 L 128
L
Sbjct: 263 L 263
Score = 42.4 bits (98), Expect = 0.001
Identities = 23/51 (45%), Positives = 28/51 (54%)
Query: 78 TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
TPLH AA +G + +E LL GA+ RD GL PL A GH E +L
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLL 110
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/51 (43%), Positives = 29/51 (56%)
Query: 78 TPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECARVL 128
TPLH+AA + E LL GAD +D+ GL PL A GH++ A +L
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALL 731
Score = 38.9 bits (89), Expect = 0.014
Identities = 31/94 (32%), Positives = 42/94 (44%), Gaps = 3/94 (3%)
Query: 23 VEELLRCGADPNLVLEDGAAAVHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHV 82
V+ LL+ GAD + + +H A H L++ G NA + TPLH
Sbjct: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGH---YEVTELLVKHGACVNAMDLWQFTPLHE 283
Query: 83 AAAWGCRRGLELLLSQGADPALRDQDGLRPLDLA 116
AA+ LLLS GADP L + +DLA
Sbjct: 284 AASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 38.5 bits (88), Expect = 0.018
Identities = 36/122 (29%), Positives = 52/122 (42%), Gaps = 8/122 (6%)
Query: 12 RDALREEEPWAVEELLRCGADP---NLVLEDG--AAAVHLAAGARHPRGLRCLGALLRQG 66
+D L E EE + P N DG + +HLAAG ++ + LL+ G
Sbjct: 178 KDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNR---VKIVQLLLQHG 234
Query: 67 GDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPALRDQDGLRPLDLALQQGHLECAR 126
D +A+ L PLH A ++G ELL+ GA D PL A + +E
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCS 294
Query: 127 VL 128
+L
Sbjct: 295 LL 296
Score = 38.5 bits (88), Expect = 0.018
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Query: 44 VHLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADPA 103
+H AAG + + LL+ G D +A+ L PLH A ++G ELL+ GA
Sbjct: 530 LHFAAGYNR---VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN 586
Query: 104 LRDQDGLRPLDLALQQGHLECARVL 128
+ D PL A +G E ++L
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLL 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,559,778
Number of Sequences: 37866
Number of extensions: 1551794
Number of successful extensions: 9255
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 270
Number of HSP's successfully gapped in prelim test: 309
Number of HSP's that attempted gapping in prelim test: 6317
Number of HSP's gapped (non-prelim): 2611
length of query: 615
length of database: 18,247,518
effective HSP length: 108
effective length of query: 507
effective length of database: 14,157,990
effective search space: 7178100930
effective search space used: 7178100930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.