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Search of human proteins with 167900450
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
(997 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 2001 0.0
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 2001 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 1374 0.0
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 1374 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 480 e-135
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 466 e-131
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 466 e-131
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 436 e-122
gi|19115964 phospholipase C delta 3 [Homo sapiens] 421 e-117
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 350 4e-96
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 339 9e-93
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 339 9e-93
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 335 1e-91
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 332 1e-90
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 332 1e-90
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 328 1e-89
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 328 1e-89
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 279 8e-75
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 199 8e-51
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 186 9e-47
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 185 2e-46
gi|11386139 phospholipase C beta 3 [Homo sapiens] 184 3e-46
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 162 1e-39
gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens] 43 0.001
gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens] 43 0.002
gi|47078261 double C2-like domains, alpha [Homo sapiens] 42 0.002
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 42 0.004
gi|209447073 synaptotagmin I [Homo sapiens] 40 0.011
gi|5032139 synaptotagmin I [Homo sapiens] 40 0.011
gi|209447070 synaptotagmin I [Homo sapiens] 40 0.011
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 2001 bits (5185), Expect = 0.0
Identities = 997/997 (100%), Positives = 997/997 (100%)
Query: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60
MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL
Sbjct: 99 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 158
Query: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120
DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL
Sbjct: 159 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 218
Query: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180
RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA
Sbjct: 219 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 278
Query: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240
KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF
Sbjct: 279 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 338
Query: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300
LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ
Sbjct: 339 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 398
Query: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360
DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN
Sbjct: 399 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 458
Query: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420
RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE
Sbjct: 459 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 518
Query: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQ 480
APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQ
Sbjct: 519 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQ 578
Query: 481 IRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKF 540
IRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKF
Sbjct: 579 IRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKF 638
Query: 541 LSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPS 600
LSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPS
Sbjct: 639 LSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPS 698
Query: 601 IMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIP 660
IMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIP
Sbjct: 699 IMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIP 758
Query: 661 ADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFEC 720
ADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFEC
Sbjct: 759 ADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFEC 818
Query: 721 LQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNI 780
LQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNI
Sbjct: 819 LQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNI 878
Query: 781 GLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSD 840
GLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSD
Sbjct: 879 GLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSD 938
Query: 841 NTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKA 900
NTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKA
Sbjct: 939 NTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKA 998
Query: 901 GMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLA 960
GMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLA
Sbjct: 999 GMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLA 1058
Query: 961 CLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL 997
CLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL
Sbjct: 1059 CLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL 1095
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 2001 bits (5185), Expect = 0.0
Identities = 997/997 (100%), Positives = 997/997 (100%)
Query: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60
MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL
Sbjct: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60
Query: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120
DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL
Sbjct: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120
Query: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180
RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA
Sbjct: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180
Query: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240
KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF
Sbjct: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240
Query: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300
LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ
Sbjct: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300
Query: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360
DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN
Sbjct: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360
Query: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420
RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE
Sbjct: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420
Query: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQ 480
APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQ
Sbjct: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQ 480
Query: 481 IRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKF 540
IRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKF
Sbjct: 481 IRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKF 540
Query: 541 LSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPS 600
LSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPS
Sbjct: 541 LSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPS 600
Query: 601 IMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIP 660
IMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIP
Sbjct: 601 IMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIP 660
Query: 661 ADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFEC 720
ADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFEC
Sbjct: 661 ADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFEC 720
Query: 721 LQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNI 780
LQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNI
Sbjct: 721 LQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNI 780
Query: 781 GLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSD 840
GLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSD
Sbjct: 781 GLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSD 840
Query: 841 NTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKA 900
NTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKA
Sbjct: 841 NTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKA 900
Query: 901 GMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLA 960
GMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLA
Sbjct: 901 GMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLA 960
Query: 961 CLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL 997
CLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL
Sbjct: 961 CLSCGLSKAPSSSAEAKSKRSLEAIEEKESSEENGKL 997
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 1374 bits (3556), Expect = 0.0
Identities = 667/999 (66%), Positives = 807/999 (80%), Gaps = 8/999 (0%)
Query: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60
MP+EKKISSA+DCI+ M G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 127 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 186
Query: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120
DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 187 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 246
Query: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180
RYL+S K LD +E +Q+ R W+ +F DVD G + +V+ I+ LNP LK +
Sbjct: 247 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 306
Query: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240
KI LKFKE+ KSK+K T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD DLM+F
Sbjct: 307 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 366
Query: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300
LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 367 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 426
Query: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360
DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++
Sbjct: 427 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 486
Query: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420
+ MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G+KLYT
Sbjct: 487 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 546
Query: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQ-- 478
+P ESYLPSP+ LK I++K KKL S+ +EG+VTDEDE AEMS+RM + N EQ
Sbjct: 547 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 605
Query: 479 ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534
K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E AS+ ANE P DFV
Sbjct: 606 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 665
Query: 535 NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594
NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 666 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 725
Query: 595 YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654
YVLRP+IMR+EVS+FSANTK +PGVSP LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 726 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785
Query: 655 EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714
EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 786 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 845
Query: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774
TIPFECLQ GYRHVPL+S G+++ H +LFVH+AITNR GGGK KR LSVR GKK REY
Sbjct: 846 TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 905
Query: 775 TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834
LR + +KT+D++FK A P+R+A D+RENMQNA+VS KELCGL +A+L QC+L +S
Sbjct: 906 ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 965
Query: 835 RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKI 894
R + DNTP V L + + +P +E G +P+V KK++T YD+MIQ + LIE AD V EKI
Sbjct: 966 RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKI 1025
Query: 895 VQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENM 954
V CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKNE +EN+
Sbjct: 1026 VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENL 1085
Query: 955 KQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 992
KQI A +SCGL+K + +A+ K +RSLE I EK + E
Sbjct: 1086 KQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 1124
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 1374 bits (3556), Expect = 0.0
Identities = 667/999 (66%), Positives = 807/999 (80%), Gaps = 8/999 (0%)
Query: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60
MP+EKKISSA+DCI+ M G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60
Query: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120
DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120
Query: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180
RYL+S K LD +E +Q+ R W+ +F DVD G + +V+ I+ LNP LK +
Sbjct: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180
Query: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240
KI LKFKE+ KSK+K T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD DLM+F
Sbjct: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240
Query: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300
LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300
Query: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360
DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++
Sbjct: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360
Query: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420
+ MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G+KLYT
Sbjct: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420
Query: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQ-- 478
+P ESYLPSP+ LK I++K KKL S+ +EG+VTDEDE AEMS+RM + N EQ
Sbjct: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 479
Query: 479 ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534
K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E AS+ ANE P DFV
Sbjct: 480 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 539
Query: 535 NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594
NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 540 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 599
Query: 595 YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654
YVLRP+IMR+EVS+FSANTK +PGVSP LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 600 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659
Query: 655 EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714
EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 660 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 719
Query: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774
TIPFECLQ GYRHVPL+S G+++ H +LFVH+AITNR GGGK KR LSVR GKK REY
Sbjct: 720 TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 779
Query: 775 TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834
LR + +KT+D++FK A P+R+A D+RENMQNA+VS KELCGL +A+L QC+L +S
Sbjct: 780 ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 839
Query: 835 RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKI 894
R + DNTP V L + + +P +E G +P+V KK++T YD+MIQ + LIE AD V EKI
Sbjct: 840 RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKI 899
Query: 895 VQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENM 954
V CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKNE +EN+
Sbjct: 900 VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENL 959
Query: 955 KQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 992
KQI A +SCGL+K + +A+ K +RSLE I EK + E
Sbjct: 960 KQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 998
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 480 bits (1236), Expect = e-135
Identities = 288/753 (38%), Positives = 426/753 (56%), Gaps = 37/753 (4%)
Query: 17 MQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTET 76
MQ G ++KVR S R+F L D + + K IS ++ IR G ++E
Sbjct: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77
Query: 77 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
R+ LA+++ + F+I+ +LDL+ANS + A IW+ GL+ LV D +
Sbjct: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128
Query: 137 NQNTPRF-MWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEK 195
+ R WL F+ D + +G M L+ +N + + F Q +
Sbjct: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185
Query: 196 LTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 255
+ + EEF + + L R EV L S + + L + + FL+ EQ T ++
Sbjct: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245
Query: 256 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 315
L++I RYE S+ G+ + L++DGF YL S + DIF+P + QDMTQPL+HY+I +SH
Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
Query: 316 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 375
NTYL+ DQ G + + GYIRALK GCR VE+DV DG EP++ + + +T+ + F+ V+
Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365
Query: 376 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYT---EAPLPSESYLPSP 432
+ ++AF S+YP+IL L HCS QQ+ MA+ + ++ G +L + + LP++ LPSP
Sbjct: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQ--LPSP 423
Query: 433 EKLKRMIIVKGKKLPSDPDV--LEGEVTDEDEEAEMSRRMSVDYNGEQKQIR-------- 482
E+L+R I+VKGKKL + D+ E E E EE+E++ + E ++
Sbjct: 424 EELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKK 483
Query: 483 -----LCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYN 537
LC LS LV KSV +R F S + +++E+ SFSET+A R+ E +FV +N
Sbjct: 484 KSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHN 543
Query: 538 KKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVL 597
LSR+YPS +R DSSN NPQ+ WN GCQ+VAMN QT G MD+ G F QNGGCGYVL
Sbjct: 544 TWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVL 603
Query: 598 RPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIH 657
+P +RD S F K I P L I++ISGQ PK +G ++DP V ++I
Sbjct: 604 KPDFLRDIQSSFHPE-KPISP-FKAQTLLIQVISGQQLPK-VDKTKEGSIVDPLVKVQIF 660
Query: 658 GIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTI 716
G+ D + Q T V+ N NP + +T F+V +PELAM+RFVV+D D+ ++FIGQYT+
Sbjct: 661 GVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTL 720
Query: 717 PFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
P+ C+Q GYRH+ L S G + ++FV+I I
Sbjct: 721 PWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 466 bits (1199), Expect = e-131
Identities = 291/745 (39%), Positives = 412/745 (55%), Gaps = 30/745 (4%)
Query: 20 GCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDL---EKAKLDISAIKEIRLGKNTET 76
G +L KV+ +S RF+ L D + + W+ S+K + E I I+E+R+G TE
Sbjct: 25 GSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRMGHRTEG 83
Query: 77 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
A + ED FSI+ + +LDL+A S A WV GL ++ S M+
Sbjct: 84 LEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGS----MDQ 137
Query: 137 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKL 196
Q W+ + AD + + M +K+LN + ++ R F+E S+
Sbjct: 138 RQKLQH--WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ--- 192
Query: 197 TTRVTEEEFCEAFCELCT-RPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 255
T E+E EAF ++ T R E+ + + + E L + L+ FL+ +Q +
Sbjct: 193 -TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 251
Query: 256 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 315
L +I RYE SE + + + DGF YLLS++ F ++V QDM QPLSHY +++SH
Sbjct: 252 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 311
Query: 316 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 375
NTYL+EDQ GP+ YIRAL GCR +ELD DG + EPI+ + T+ + F V+
Sbjct: 312 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 371
Query: 376 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKL 435
I +AF AS YP+IL L NHC+L QQ+VMA+ + + G L + LPSPE+L
Sbjct: 372 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL 431
Query: 436 KRMIIVKGKKLPS-DPDVLEG-----EVTDEDEEAEM---SRRMSVDYNGEQKQIRLCRE 486
K I++KGKKL P EG V+DEDE AEM + R V + ++ ++RL +E
Sbjct: 432 KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE 491
Query: 487 LSDLVSICKSVQYRDFEL-SMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIY 545
LSD+V CKSV + F Q ++EM SFSE A R+ E FV +N LSRIY
Sbjct: 492 LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY 551
Query: 546 PSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDE 605
P+ R DSSN +P + WN GCQIVA+NFQTPGP MD++ G F NG CGYVL+P+ +RD
Sbjct: 552 PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP 611
Query: 606 VSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSE 665
F+ P + L+I++ISGQ PK K ++DP V +EIHG+ D +
Sbjct: 612 NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNK--NKNSIVDPKVTVEIHGVSRDVAS 669
Query: 666 QRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTIPFECLQPG 724
++T + N NP +D F F+V +P+LA+IRF+V D D ++FIGQ TIP L+ G
Sbjct: 670 RQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 729
Query: 725 YRHVPLRSFVGDIMEHVTLFVHIAI 749
YRHV L S GD TLFV I++
Sbjct: 730 YRHVHLMSKNGDQHPSATLFVKISL 754
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 466 bits (1199), Expect = e-131
Identities = 291/745 (39%), Positives = 412/745 (55%), Gaps = 30/745 (4%)
Query: 20 GCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDL---EKAKLDISAIKEIRLGKNTET 76
G +L KV+ +S RF+ L D + + W+ S+K + E I I+E+R+G TE
Sbjct: 46 GSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRMGHRTEG 104
Query: 77 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
A + ED FSI+ + +LDL+A S A WV GL ++ S M+
Sbjct: 105 LEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGS----MDQ 158
Query: 137 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKL 196
Q W+ + AD + + M +K+LN + ++ R F+E S+
Sbjct: 159 RQKLQH--WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ--- 213
Query: 197 TTRVTEEEFCEAFCELCT-RPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 255
T E+E EAF ++ T R E+ + + + E L + L+ FL+ +Q +
Sbjct: 214 -TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
Query: 256 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 315
L +I RYE SE + + + DGF YLLS++ F ++V QDM QPLSHY +++SH
Sbjct: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
Query: 316 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 375
NTYL+EDQ GP+ YIRAL GCR +ELD DG + EPI+ + T+ + F V+
Sbjct: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
Query: 376 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKL 435
I +AF AS YP+IL L NHC+L QQ+VMA+ + + G L + LPSPE+L
Sbjct: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL 452
Query: 436 KRMIIVKGKKLPS-DPDVLEG-----EVTDEDEEAEM---SRRMSVDYNGEQKQIRLCRE 486
K I++KGKKL P EG V+DEDE AEM + R V + ++ ++RL +E
Sbjct: 453 KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE 512
Query: 487 LSDLVSICKSVQYRDFEL-SMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIY 545
LSD+V CKSV + F Q ++EM SFSE A R+ E FV +N LSRIY
Sbjct: 513 LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY 572
Query: 546 PSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDE 605
P+ R DSSN +P + WN GCQIVA+NFQTPGP MD++ G F NG CGYVL+P+ +RD
Sbjct: 573 PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP 632
Query: 606 VSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSE 665
F+ P + L+I++ISGQ PK K ++DP V +EIHG+ D +
Sbjct: 633 NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNK--NKNSIVDPKVTVEIHGVSRDVAS 690
Query: 666 QRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTIPFECLQPG 724
++T + N NP +D F F+V +P+LA+IRF+V D D ++FIGQ TIP L+ G
Sbjct: 691 RQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750
Query: 725 YRHVPLRSFVGDIMEHVTLFVHIAI 749
YRHV L S GD TLFV I++
Sbjct: 751 YRHVHLMSKNGDQHPSATLFVKISL 775
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 436 bits (1120), Expect = e-122
Identities = 240/602 (39%), Positives = 377/602 (62%), Gaps = 18/602 (2%)
Query: 154 DVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELC 213
D G I LE T L+++L+ ++ FK+ + K+ R+T EEF + +
Sbjct: 13 DFRGGKINLEKTQ-RLLEKLDIRCSYIHVKQIFKDNDRLKQG---RITIEEFRAIYRIIT 68
Query: 214 TRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGF 273
R E+ + S+N++ L A++L FL EQ +++ I +II++YE EE R+
Sbjct: 69 HREEIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQ 128
Query: 274 LAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGY 333
++++GFT+Y+ S EC +F E +KV QDMT PL+ Y+I++SHNTYL+ DQ GP+D+ GY
Sbjct: 129 MSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGY 188
Query: 334 IRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCL 393
+ AL GCR +E+D DG+ NEP++ + +T+ + F++VI+ I+K+AF+ S+YP++L L
Sbjct: 189 VSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSL 248
Query: 394 GNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVL 453
NHCS QQ+VMA ++ FG L ++ LPSPE LK I+VK KK+ + +
Sbjct: 249 ENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETH 308
Query: 454 EGEVTD-----EDEEAEMSRRMSVDYNGEQK--QIRLCRELSDLVSICKSVQYRDFELSM 506
E + +D +D+E + + V ++K ++++ LSDLV K+ +++ F+ S
Sbjct: 309 ERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSR 368
Query: 507 KSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGC 566
Q + E S ET+A +++ +F+ + +KF++RIYP A R DSSN NPQ+FWN GC
Sbjct: 369 LYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 428
Query: 567 QIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALH 626
Q+VA+NFQTPG MDL G FL NGG GY+L+P +R+ SYF N I G+ P+ L
Sbjct: 429 QMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYF--NPSNIKEGM-PITLT 485
Query: 627 IKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEF 686
I++ISG P + KGD + V IE+ G+P D +Q+T+ +++N+ +P ++ETF F
Sbjct: 486 IRLISGIQLPLTHSSSNKGDSL---VIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTF 542
Query: 687 QVNLPELAMIRFVVLDDDYI-GDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 745
+++PELA+IRFVV I G+EF+GQYT+P C+ GYR +PL S +G+ +E +LFV
Sbjct: 543 IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFV 602
Query: 746 HI 747
++
Sbjct: 603 YV 604
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 421 bits (1081), Expect = e-117
Identities = 272/753 (36%), Positives = 394/753 (52%), Gaps = 51/753 (6%)
Query: 17 MQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLD----ISAIKEIRLGK 72
M G L+K+R + R + L D ++ ++ + + +A + I+ +R G
Sbjct: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQ---RRIPRAPSQHIFFVQHIEAVREGH 121
Query: 73 NTETFRNNG--LADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQP 130
+E R G A C AF ++LDL A +A+ A WV GL L +R
Sbjct: 122 QSEGLRRFGGAFAPARCLTIAFK----GRRKNLDLAAPTAEEAQRWVRGLTKLRAR---- 173
Query: 131 LDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQ 190
LD M + W+ + AD + + M L++ +N + + L FKE
Sbjct: 174 LDAMSQRERLDH--WIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECD 231
Query: 191 KSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHI 250
S EEF L RPE+ + Q S L A +L+ FLE +QG
Sbjct: 232 HSNNDRLEGAEIEEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287
Query: 251 TEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYY 310
T +I+ YEL+E +Q + +DGF YLLS E D V QDM QPL+HY+
Sbjct: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347
Query: 311 INASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSF 370
I++SHNTYL + Q GP+ Y+RA GCR VELD +G EP++ + + +T+ + F
Sbjct: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407
Query: 371 RSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEA-PLPSESYL 429
R V++ + AF S YP+IL L NHC L QQ MA+ + + G+ L T+A P+ L
Sbjct: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEEL 467
Query: 430 PSPEKLKRMIIVKGKKLPSD--------PDVLEGEVTDEDEEAEM----SRRMSVDYNGE 477
PSPE+LK ++VKGKKLP+ D E E DE+EE E+ RR++
Sbjct: 468 PSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLA------ 521
Query: 478 QKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYN 537
KQI ELS L C + + R + + ++ S SE +A ++ E FV +N
Sbjct: 522 -KQI--SPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
Query: 538 KKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVL 597
+ L+R+YP +R++S+N +PQ+ WN GCQ+VA+NFQTPG MDL+ G FL NG CGYVL
Sbjct: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
Query: 598 RPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIH 657
+P+ +R S F PG L I++++ Q PK A ++DP V IEIH
Sbjct: 639 KPACLRQPDSTFDPE----YPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIH 693
Query: 658 GIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTI 716
G+PADC+ Q T V N NP + +T +FQ+ PELA++RFVV D D ++F+GQ+T+
Sbjct: 694 GVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTL 753
Query: 717 PFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
P L+ GYRH+ L S G + TLF+ I I
Sbjct: 754 PLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 350 bits (898), Expect = 4e-96
Identities = 202/499 (40%), Positives = 299/499 (59%), Gaps = 17/499 (3%)
Query: 13 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 72
C+ MQ G ++ K+R S+ RF+ LD +RW PS+K+ EKAK+ I +I+E+ G+
Sbjct: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103
Query: 73 NTETFRN--NGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQP 130
+E F+ +G D +C FSI HG + ESLDLV+ S++VA WV+GLRYL++
Sbjct: 104 QSEVFQRYPDGSFDP---NCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDE 160
Query: 131 LDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQ 190
D + Q T R WLK F+ AD +G+G + ++L+ +LN L +++ F+E
Sbjct: 161 -DSLARRQRT-RDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD 218
Query: 191 KSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHI 250
+ T EEFC + + TR ++Y L++ S +K++LDA L FL+ EQ + +
Sbjct: 219 TDDHQGTLGF--EEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGV 276
Query: 251 TEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYY 310
T + C DII ++E E + KG L IDGFT Y S DIF+PE V QDMTQPLSHY+
Sbjct: 277 TLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYF 336
Query: 311 INASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSF 370
I +SHNTYL+ DQ + ++ Y L+ GCR VE+D DG D EPI+ + +T+ + F
Sbjct: 337 ITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILF 396
Query: 371 RSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKL-YTEAPLPSESYL 429
+ VIE INK+AF+ +EYP+IL + NHCS+ QQK MAQ + + G+KL + + L
Sbjct: 397 KDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTL 456
Query: 430 PSPEKLKRMIIVKGKKLPSD--PDVLEGEVTDEDEEAEMS---RRMSVDYNGEQKQIRLC 484
PSP+ LK I+VKGKKLP++ D EGEV+DED E+ + ++ D + +K++
Sbjct: 457 PSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENT 516
Query: 485 RELSDLVSICKSVQYRDFE 503
+ L S+ K + RD E
Sbjct: 517 AK-RKLDSLIKESKIRDCE 534
Score = 264 bits (675), Expect = 3e-70
Identities = 140/315 (44%), Positives = 200/315 (63%), Gaps = 16/315 (5%)
Query: 442 KGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRD 501
KG KL V EG DE + S ++K ++L R LSDLV KSV D
Sbjct: 586 KGSKLKKAASVEEG-----DEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHD 640
Query: 502 FELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDF 561
E M++ + W++ SFSET+A +I + P ++ +N++ LSRIYPS+ R+DSSN NPQ F
Sbjct: 641 IE--MEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPF 698
Query: 562 WNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVS 621
WN GCQ+VA+N+Q+ G M+ L+ F NGGCGYVL+P M V F+ N++ LPG
Sbjct: 699 WNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDPLPGQL 756
Query: 622 PLALHIKIISGQNFPKPKGACA--KGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPI 679
L ++IISGQ PKP+ + +G++IDP+V +EI G+P DCS ++T+ V N NP
Sbjct: 757 KKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPT 816
Query: 680 FDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIME 739
++ET F V++PE+A++RF+V D D IG +FIGQ T+ F + PGYRHV L ME
Sbjct: 817 WEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEG-----ME 871
Query: 740 HVTLFVHIAITNRSG 754
++FVH+A+++ SG
Sbjct: 872 EASIFVHVAVSDISG 886
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 339 bits (869), Expect = 9e-93
Identities = 196/497 (39%), Positives = 293/497 (58%), Gaps = 12/497 (2%)
Query: 13 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 72
C+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGR 76
Query: 73 NTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLD 132
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 77 QSEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-D 134
Query: 133 FMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKS 192
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E
Sbjct: 135 SLAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
Query: 193 KEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE 252
+ + T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T
Sbjct: 194 ENQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
Query: 253 DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYIN 312
D CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI
Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
Query: 313 ASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRS 372
+SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR
Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
Query: 373 VIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPS 431
V+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPS
Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
Query: 432 PEKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCRE 486
P+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFI 491
Query: 487 LSDLVSICKSVQYRDFE 503
L S+ K Q RD E
Sbjct: 492 RKKLESLLKESQIRDKE 508
Score = 233 bits (594), Expect = 7e-61
Identities = 129/304 (42%), Positives = 182/304 (59%), Gaps = 18/304 (5%)
Query: 458 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 513
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 568 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 624
Query: 514 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 573
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 625 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 684
Query: 574 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 632
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 685 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 741
Query: 633 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 690
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 742 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 801
Query: 691 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 750
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 802 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITIN 856
Query: 751 NRSG 754
G
Sbjct: 857 EIYG 860
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 339 bits (869), Expect = 9e-93
Identities = 196/497 (39%), Positives = 293/497 (58%), Gaps = 12/497 (2%)
Query: 13 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 72
C+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGR 76
Query: 73 NTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLD 132
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 77 QSEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-D 134
Query: 133 FMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKS 192
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E
Sbjct: 135 SLAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
Query: 193 KEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE 252
+ + T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T
Sbjct: 194 ENQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
Query: 253 DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYIN 312
D CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI
Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
Query: 313 ASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRS 372
+SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR
Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
Query: 373 VIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPS 431
V+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPS
Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
Query: 432 PEKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCRE 486
P+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFI 491
Query: 487 LSDLVSICKSVQYRDFE 503
L S+ K Q RD E
Sbjct: 492 RKKLESLLKESQIRDKE 508
Score = 233 bits (594), Expect = 7e-61
Identities = 129/304 (42%), Positives = 182/304 (59%), Gaps = 18/304 (5%)
Query: 458 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 513
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 568 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 624
Query: 514 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 573
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 625 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 684
Query: 574 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 632
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 685 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 741
Query: 633 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 690
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 742 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 801
Query: 691 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 750
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 802 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITIN 856
Query: 751 NRSG 754
G
Sbjct: 857 EIYG 860
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 335 bits (860), Expect = 1e-91
Identities = 195/496 (39%), Positives = 292/496 (58%), Gaps = 12/496 (2%)
Query: 14 ISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKN 73
+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGRQ 59
Query: 74 TETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDF 133
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 60 SEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-DS 117
Query: 134 MEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSK 193
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E +
Sbjct: 118 LAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 176
Query: 194 EKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITED 253
+ T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T D
Sbjct: 177 NQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTD 234
Query: 254 ICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINA 313
CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI +
Sbjct: 235 YCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIAS 294
Query: 314 SHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSV 373
SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR V
Sbjct: 295 SHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDV 354
Query: 374 IEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPSP 432
+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPSP
Sbjct: 355 VETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSP 414
Query: 433 EKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCREL 487
+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 415 QSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIR 474
Query: 488 SDLVSICKSVQYRDFE 503
L S+ K Q RD E
Sbjct: 475 KKLESLLKESQIRDKE 490
Score = 234 bits (597), Expect = 3e-61
Identities = 135/329 (41%), Positives = 190/329 (57%), Gaps = 19/329 (5%)
Query: 458 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 513
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 550 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 606
Query: 514 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 573
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 607 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 666
Query: 574 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 632
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 667 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 723
Query: 633 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 690
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 724 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 783
Query: 691 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 750
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 784 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITI- 837
Query: 751 NRSGGGKAQKRSLSVRMGKKVREYTMLRN 779
N G Q + L K R + N
Sbjct: 838 NEIYGKNRQLQGLKGLFNKNPRHSSSENN 866
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 332 bits (850), Expect = 1e-90
Identities = 238/775 (30%), Positives = 384/775 (49%), Gaps = 86/775 (11%)
Query: 39 LDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCA 91
L TD Q + + ++ E LD+S +K+ R G++ + ++ L + + E
Sbjct: 43 LRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRM 102
Query: 92 FSILHGE---NYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKT 148
++++G N L+LVA +VA W + + L + + + N + F+
Sbjct: 103 ITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAY 156
Query: 149 VFEAADVDGNG-IMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTR--VTEEEF 205
V G I L++ + + + K + L+ + S+ + T E +
Sbjct: 157 TKLKLQVTPEGRIPLKN----IYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVY 212
Query: 206 CEAFCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI------ 258
LC RPE+ + + +K+K YL + +M F+ +Q + E + +
Sbjct: 213 RVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272
Query: 259 --IRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHN 316
I +YE + +KG +++DGF +YL E + PE+ + +DM+QPLSHY+IN+SHN
Sbjct: 273 VLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN 332
Query: 317 TYLIEDQFRGPADINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVI 374
TYL Q G + + Y + L GCR VELD G ++ EP++ + MTT +SF+ VI
Sbjct: 333 TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVI 392
Query: 375 EVINKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYL 429
E I + AF S +P++L NH P+Q+ MA+ + +FG+ L E PL S L
Sbjct: 393 EAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPL 452
Query: 430 PSPEKLKRMIIVKGKKL-----------------------------PSDPDVLEGEV-TD 459
PSP L I+VK KK PS P E + +D
Sbjct: 453 PSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESD 512
Query: 460 EDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSE 519
+D++ + ++ S+D + E+S+LV+ + V++ FE+S K +EM SF E
Sbjct: 513 DDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVE 572
Query: 520 TEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 579
T+ + P +FV YNK LSRIYP R+DSSN PQ FWN GCQ+VA+NFQT
Sbjct: 573 TKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA 632
Query: 580 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPK 639
M ++ G + NG GY L+P MR +F T+GI+ G+ L +KIISGQ K
Sbjct: 633 MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK 692
Query: 640 GACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQNSDNPIFDE---TFEFQVNLPELA 694
+ YV +++ G+P D + +TKT Q N+ NP+++E F+ +V LP LA
Sbjct: 693 --------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLA 743
Query: 695 MIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
+R V ++ G +FIG +P + ++PGY ++ LR+ + +FV+I +
Sbjct: 744 CLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV 795
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 332 bits (850), Expect = 1e-90
Identities = 238/775 (30%), Positives = 384/775 (49%), Gaps = 86/775 (11%)
Query: 39 LDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCA 91
L TD Q + + ++ E LD+S +K+ R G++ + ++ L + + E
Sbjct: 43 LRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRM 102
Query: 92 FSILHGE---NYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKT 148
++++G N L+LVA +VA W + + L + + + N + F+
Sbjct: 103 ITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAY 156
Query: 149 VFEAADVDGNG-IMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTR--VTEEEF 205
V G I L++ + + + K + L+ + S+ + T E +
Sbjct: 157 TKLKLQVTPEGRIPLKN----IYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVY 212
Query: 206 CEAFCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI------ 258
LC RPE+ + + +K+K YL + +M F+ +Q + E + +
Sbjct: 213 RVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQ 272
Query: 259 --IRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHN 316
I +YE + +KG +++DGF +YL E + PE+ + +DM+QPLSHY+IN+SHN
Sbjct: 273 VLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN 332
Query: 317 TYLIEDQFRGPADINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVI 374
TYL Q G + + Y + L GCR VELD G ++ EP++ + MTT +SF+ VI
Sbjct: 333 TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVI 392
Query: 375 EVINKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYL 429
E I + AF S +P++L NH P+Q+ MA+ + +FG+ L E PL S L
Sbjct: 393 EAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPL 452
Query: 430 PSPEKLKRMIIVKGKKL-----------------------------PSDPDVLEGEV-TD 459
PSP L I+VK KK PS P E + +D
Sbjct: 453 PSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESD 512
Query: 460 EDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSE 519
+D++ + ++ S+D + E+S+LV+ + V++ FE+S K +EM SF E
Sbjct: 513 DDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVE 572
Query: 520 TEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPM 579
T+ + P +FV YNK LSRIYP R+DSSN PQ FWN GCQ+VA+NFQT
Sbjct: 573 TKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA 632
Query: 580 MDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPK 639
M ++ G + NG GY L+P MR +F T+GI+ G+ L +KIISGQ K
Sbjct: 633 MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKK 692
Query: 640 GACAKGDVIDPYVCIEIHGIPADCSEQ--RTKTVQQNSDNPIFDE---TFEFQVNLPELA 694
+ YV +++ G+P D + +TKT Q N+ NP+++E F+ +V LP LA
Sbjct: 693 --------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFK-KVVLPTLA 743
Query: 695 MIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
+R V ++ G +FIG +P + ++PGY ++ LR+ + +FV+I +
Sbjct: 744 CLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEV 795
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 328 bits (842), Expect = 1e-89
Identities = 251/831 (30%), Positives = 397/831 (47%), Gaps = 121/831 (14%)
Query: 15 SFMQAGCELKKVRPNSRIY--NRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLG- 71
SF+Q G + S ++ N F +D L W K E L+ S I IR G
Sbjct: 15 SFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGK--EGQVLECSLINSIRSGA 72
Query: 72 -----KNTETFRNNGLADQICEDCAFSILHGENYESLD---LVANSADVANIWVSGLRYL 123
K G ++ E + G + ++ +VA + +V WV GLR +
Sbjct: 73 IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSI 132
Query: 124 V----SRSKQPLDFMEGNQNTPRFMWLKTVFEA---ADVDGNGIMLEDTSVELIKQLNPT 176
+ + + P+ ++ + W+K F + I S + K +
Sbjct: 133 IHNFRANNVSPMTCLKKH-------WMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQA 185
Query: 177 LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNK-EYLDAN 235
LKE + K+ E T + E+F E ++C R ++ L +I+ +K +YL +
Sbjct: 186 LKELGL-----PSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
Query: 236 DLMLFLEAEQGVTHITEDI--------CLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSE 287
L+ FL Q + E + + II YE E+ ++KG ++ DGF +YL+S E
Sbjct: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
Query: 288 CDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELD 347
++ ++ Q+M PL+HY+I++SHNTYL QF G + + Y + L GCR VELD
Sbjct: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
Query: 348 VSD--GSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVM 405
D G D EPI+ + M T + F+ VI+ I + AFV SEYP+IL NHCS QQ M
Sbjct: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
Query: 406 AQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIVKGKKL--------------- 446
++ + +FG+ L +A PL LPSP LKR I++K K+L
Sbjct: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
Query: 447 ------PSDPDVLEG------EVTDEDEEA----EMSRRMSVDYNGEQKQI--------- 481
S ++LE E D++EEA + +S D G ++ +
Sbjct: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
Query: 482 -------------------RLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEA 522
+ LS +++ + V+++ F ++ + ++ M SF+E+
Sbjct: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
Query: 523 SRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDL 582
+ +FVNYNK+ +SRIYP R+DSSN PQ FWN GCQ+V++N+QTP M L
Sbjct: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
Query: 583 HTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGAC 642
+ G F NG CGY+L+P MR F ++ + GV +++ISGQ K
Sbjct: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK--- 717
Query: 643 AKGDVIDPYVCIEIHGIPADC--SEQRTKTVQQNSDNPIF-DETFEF-QVNLPELAMIRF 698
I YV ++++G+P D E RT+ V N NP++ +E+F F +V LP+LA++R
Sbjct: 718 -----IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRI 772
Query: 699 VVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
V DD+ ++ IGQ +P + LQ GYRH+ LR+ + T+F +I +
Sbjct: 773 AVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 328 bits (842), Expect = 1e-89
Identities = 251/831 (30%), Positives = 397/831 (47%), Gaps = 121/831 (14%)
Query: 15 SFMQAGCELKKVRPNSRIY--NRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLG- 71
SF+Q G + S ++ N F +D L W K E L+ S I IR G
Sbjct: 15 SFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGK--EGQVLECSLINSIRSGA 72
Query: 72 -----KNTETFRNNGLADQICEDCAFSILHGENYESLD---LVANSADVANIWVSGLRYL 123
K G ++ E + G + ++ +VA + +V WV GLR +
Sbjct: 73 IPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSI 132
Query: 124 V----SRSKQPLDFMEGNQNTPRFMWLKTVFEA---ADVDGNGIMLEDTSVELIKQLNPT 176
+ + + P+ ++ + W+K F + I S + K +
Sbjct: 133 IHNFRANNVSPMTCLKKH-------WMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQA 185
Query: 177 LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNK-EYLDAN 235
LKE + K+ E T + E+F E ++C R ++ L +I+ +K +YL +
Sbjct: 186 LKELGL-----PSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD 240
Query: 236 DLMLFLEAEQGVTHITEDI--------CLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSE 287
L+ FL Q + E + + II YE E+ ++KG ++ DGF +YL+S E
Sbjct: 241 QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE 300
Query: 288 CDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELD 347
++ ++ Q+M PL+HY+I++SHNTYL QF G + + Y + L GCR VELD
Sbjct: 301 NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD 360
Query: 348 VSD--GSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVM 405
D G D EPI+ + M T + F+ VI+ I + AFV SEYP+IL NHCS QQ M
Sbjct: 361 CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM 420
Query: 406 AQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIVKGKKL--------------- 446
++ + +FG+ L +A PL LPSP LKR I++K K+L
Sbjct: 421 SKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM 480
Query: 447 ------PSDPDVLEG------EVTDEDEEA----EMSRRMSVDYNGEQKQI--------- 481
S ++LE E D++EEA + +S D G ++ +
Sbjct: 481 MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV 540
Query: 482 -------------------RLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEA 522
+ LS +++ + V+++ F ++ + ++ M SF+E+
Sbjct: 541 TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG 600
Query: 523 SRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDL 582
+ +FVNYNK+ +SRIYP R+DSSN PQ FWN GCQ+V++N+QTP M L
Sbjct: 601 LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL 660
Query: 583 HTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGAC 642
+ G F NG CGY+L+P MR F ++ + GV +++ISGQ K
Sbjct: 661 NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK--- 717
Query: 643 AKGDVIDPYVCIEIHGIPADC--SEQRTKTVQQNSDNPIF-DETFEF-QVNLPELAMIRF 698
I YV ++++G+P D E RT+ V N NP++ +E+F F +V LP+LA++R
Sbjct: 718 -----IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRI 772
Query: 699 VVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
V DD+ ++ IGQ +P + LQ GYRH+ LR+ + T+F +I +
Sbjct: 773 AVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 279 bits (714), Expect = 8e-75
Identities = 238/807 (29%), Positives = 368/807 (45%), Gaps = 106/807 (13%)
Query: 46 LRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC--------AFSILHG 97
L W K++E LDI++I++ R GK + ++ L D D +++ G
Sbjct: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104
Query: 98 ENYESL---DLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAAD 154
+ L + V+ +V W + LV K PL N R +L +
Sbjct: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPL-----TANASRSTFLDKILVKLK 156
Query: 155 VDGNGIMLEDTSVELIKQLNPT-LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEA----- 208
+ N V+ Q+ P K + L + K K + E+F E
Sbjct: 157 MQLNSE--GKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDA---INPEDFPEPVYKSF 211
Query: 209 FCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITE--------DICLDII 259
LC RPE+ + +K K Y+ L F+ +Q + + D +I
Sbjct: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
Query: 260 RRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYL 319
+YE S Q+G L+ +G +L E + ++ + DMTQPL+HY+IN+SHNTYL
Sbjct: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
Query: 320 IEDQFRGPADINGYIRALKMGCRSVELDVSDGS--DNEPILCNRNNMTTHVSFRSVIEVI 377
QF G + Y + L GCR VELD G D EPI+ + MTT + F+ IE I
Sbjct: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
Query: 378 NKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYLPSP 432
+ AF S YP+IL NH P+Q+ MA+ + +FG+ L TE PL LPSP
Sbjct: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
Query: 433 EKLKRMIIVKGKKL---------------------PSDP-------------DVLEGEVT 458
E L+ I++K KK PS P ++ E EV
Sbjct: 452 EDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVE 511
Query: 459 DEDEEA------EMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYW 512
+E+EE E ++M D ++ E+S LV+ + ++ FE S + +
Sbjct: 512 EEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSY 571
Query: 513 EMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMN 572
+ SF+E +A + ++ FV+YNK+ +SRIYP R+DSSN PQ FWN GCQ+VA+N
Sbjct: 572 VISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALN 631
Query: 573 FQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISG 632
FQT M + F NG GY+L+ MR F+ + + V L I +ISG
Sbjct: 632 FQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISG 691
Query: 633 QNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ-RTK-TVQQNSDNPIF-DETFEFQ-V 688
Q + + YV +E+ G+P D + RTK + NS NP++ +E F F+ +
Sbjct: 692 QFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKI 743
Query: 689 NLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIA 748
+PELA +R V+++ G++F+G IP L GY H+ L S + LF+ +
Sbjct: 744 LMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLE 800
Query: 749 ITNRSGGGKAQKRSLSVRMGKKVREYT 775
+ + G A L+V + ++ ++
Sbjct: 801 MKDYIPGAWA---DLTVALANPIKFFS 824
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 199 bits (507), Expect = 8e-51
Identities = 154/457 (33%), Positives = 232/457 (50%), Gaps = 41/457 (8%)
Query: 42 DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENY- 100
+ + + W + +E LDI IKEIR GKN++ F Q EDC F+IL+G +
Sbjct: 48 ETRQVAWSKTADKIE-GFLDIMEIKEIRPGKNSKDFERAKAVRQK-EDCCFTILYGTQFV 105
Query: 101 -ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFM--WL-KTVFEAADVD 156
+L L A+S + A W+SGL+ L + N +TP + WL K ++
Sbjct: 106 LSTLSLAADSKEDAVNWLSGLKILHQEAM--------NASTPTIIESWLRKQIYSVDQTR 157
Query: 157 GNGIMLEDTSVELIKQLNPTLKEAK-IRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR 215
N I L + ++ +N + AK ++ KF EI K++L+ E+F + +L
Sbjct: 158 RNSISLRELKT-ILPLINFKVSSAKFLKDKFVEIGAHKDELSF----EQFHLFYKKLMFE 212
Query: 216 PEVYFL-------LVQISKNKEYLDAN-----DLMLFLEAEQGVTHITEDICLDIIRRYE 263
+ L V I N + DA+ D FL EQ H +D+ R +
Sbjct: 213 QQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQ-EHWAQDLNKVRERMTK 271
Query: 264 LSEEGRQKG---FLAIDGFTQYLLSSECDIFDPEQKKV-AQDMTQPLSHYYINASHNTYL 319
++ ++ FL +D F YL S E I+D + V QDM PLSHY+I++SHNTYL
Sbjct: 272 FIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYL 331
Query: 320 IEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINK 379
DQ R + YIR L+MGCR +ELD DG D +P++ + TT + F V++ I
Sbjct: 332 TGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKD 391
Query: 380 FAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMI 439
AFV S +P+IL + HCS+ QQ+ MA+ K+VFG+ L T+ S LPSP +L+ I
Sbjct: 392 HAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKI 451
Query: 440 IVKGKKLPSDPDV---LEGEVTDEDEEAEMSRRMSVD 473
I+K KKL DV +E + + ++ E+ S+D
Sbjct: 452 IIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSID 488
Score = 145 bits (367), Expect = 1e-34
Identities = 106/333 (31%), Positives = 164/333 (49%), Gaps = 31/333 (9%)
Query: 430 PSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEA--------EMSRRMSVDYNGE---Q 478
P + K + + K DP V TD EE E++ ++ N +
Sbjct: 864 PQGKNQKSFVFILEPKQQGDPPV--EFATDRVEELFEWFQSIREITWKIDTKENNMKYWE 921
Query: 479 KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNK 538
K + ELSDLV CK L ++ ++ E+ SF ET+A I + P D + YN+
Sbjct: 922 KNQSIAIELSDLVVYCKPTSKTKDNL--ENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979
Query: 539 KFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLR 598
K L+R+YP R+DSSN +P W CG Q+VA+NFQT M ++ F NG GYVL+
Sbjct: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039
Query: 599 PSIMRDEV--SYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656
P MR E + + IL + L +K++ ++ PK + P+V +EI
Sbjct: 1040 PESMRTEKYDPMPPESQRKIL-----MTLTVKVLGARHLPK-----LGRSIACPFVEVEI 1089
Query: 657 HGIPADCSEQRTKTVQQNSDNPIFDETFE---FQVNLPELAMIRFVVLDDDYIGD-EFIG 712
G D ++ +T V N +PI+ T E F++ P LA +RFVV ++D D F+
Sbjct: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
Query: 713 QYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFV 745
T P + ++ G+R VPL++ + +E +L V
Sbjct: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 186 bits (472), Expect = 9e-47
Identities = 109/299 (36%), Positives = 172/299 (57%), Gaps = 14/299 (4%)
Query: 478 QKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYP-EDFVNY 536
+++ ++ ELS+LV C+ V + + ++ + Y +M SF ET+A + N+ + F+ Y
Sbjct: 944 ERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQY 1003
Query: 537 NKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYV 596
N+ LSRIYP R+DSSN +P W CG Q+VA+NFQTP M ++ F+ CGYV
Sbjct: 1004 NRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYV 1063
Query: 597 LRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656
L+PS MRDE F K L G+ P A+ I+++ ++ PK +G ++ P+V IE+
Sbjct: 1064 LQPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPKN----GRG-IVCPFVEIEV 1116
Query: 657 HGIPADCSEQRTKTVQQNSDNPIFD-ETFEFQVNLPELAMIRFVVLDDDYIGDE-FIGQY 714
G D ++Q+T+ V N NP++ + F FQ++ PE A +RFVV ++D D+ F+ Q
Sbjct: 1117 AGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQA 1176
Query: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVRE 773
T P + L+ GYR VPL++ + +E +L + I I K + LS G +RE
Sbjct: 1177 TFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIF----PAKQENGDLSPFSGTSLRE 1231
Score = 185 bits (469), Expect = 2e-46
Identities = 137/448 (30%), Positives = 217/448 (48%), Gaps = 50/448 (11%)
Query: 27 RPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI 86
+ + R + F + + + + W +E A +DI IKEIR GK + F D+
Sbjct: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
Query: 87 CEDCAFS--------ILHGENY--ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
ED AF IL+G + ++L L A S D N+W+ GL +L+ + Q ++
Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI 153
Query: 137 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLN---PTLKEAKIRL--------- 184
+ WL+ F + D + + ++ Q+N P ++ + RL
Sbjct: 154 ER------WLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGD 207
Query: 185 ----KFKEIQKSKEKLTTRVTEEEFCEAFC-ELCTRPEVYFLLVQISKNKEYLDANDLML 239
+F ++ +S + + F EA RPE+ V + + +++L L
Sbjct: 208 ITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPEL--CRVSLPEFQQFLLDYQGEL 265
Query: 240 FLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVA 299
+ V D +R E + + +D F +L S E +++ + V
Sbjct: 266 WAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVC 318
Query: 300 QD-MTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPIL 358
D M PLSHY+I++SHNTYL DQF + + Y R L+MGCR +ELD DG D P++
Sbjct: 319 PDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVI 378
Query: 359 CNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLY 418
+ + +TT + F V+ I + AFVASEYP+IL + +HCS+ QQ+ MAQ KKV G+ L
Sbjct: 379 YHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL 438
Query: 419 TEAPLPSESYLPSPEKLKRMIIVKGKKL 446
T+ S LPSP +LKR I++K KKL
Sbjct: 439 TKPVEISADGLPSPNQLKRKILIKHKKL 466
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 185 bits (470), Expect = 2e-46
Identities = 109/299 (36%), Positives = 171/299 (57%), Gaps = 15/299 (5%)
Query: 478 QKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYP-EDFVNY 536
+++ ++ ELS+LV C+ V + + ++ + Y +M SF ET+A + N+ + F+ Y
Sbjct: 944 ERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQY 1003
Query: 537 NKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYV 596
N+ LSRIYP R+DSSN +P W CG Q+VA+NFQTP M ++ F+ CGYV
Sbjct: 1004 NRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYV 1063
Query: 597 LRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656
L+PS MRDE F K L G+ P A+ I+++ ++ PK +G ++ P+V IE+
Sbjct: 1064 LQPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPKN----GRG-IVCPFVEIEV 1116
Query: 657 HGIPADCSEQRTKTVQQNSDNPIFD-ETFEFQVNLPELAMIRFVVLDDDYIGDE-FIGQY 714
G D ++Q+T+ V N NP++ + F FQ++ PE A +RFVV ++D D+ F+ Q
Sbjct: 1117 AGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQA 1176
Query: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVRE 773
T P + L+ GYR VPL++ + +E +L + I I G LS G +RE
Sbjct: 1177 TFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRE 1230
Score = 185 bits (469), Expect = 2e-46
Identities = 137/448 (30%), Positives = 217/448 (48%), Gaps = 50/448 (11%)
Query: 27 RPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI 86
+ + R + F + + + + W +E A +DI IKEIR GK + F D+
Sbjct: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93
Query: 87 CEDCAFS--------ILHGENY--ESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
ED AF IL+G + ++L L A S D N+W+ GL +L+ + Q ++
Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQI 153
Query: 137 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLN---PTLKEAKIRL--------- 184
+ WL+ F + D + + ++ Q+N P ++ + RL
Sbjct: 154 ER------WLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGD 207
Query: 185 ----KFKEIQKSKEKLTTRVTEEEFCEAFC-ELCTRPEVYFLLVQISKNKEYLDANDLML 239
+F ++ +S + + F EA RPE+ V + + +++L L
Sbjct: 208 ITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPEL--CRVSLPEFQQFLLDYQGEL 265
Query: 240 FLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVA 299
+ V D +R E + + +D F +L S E +++ + V
Sbjct: 266 WAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSKENSVWNSQLDAVC 318
Query: 300 QD-MTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPIL 358
D M PLSHY+I++SHNTYL DQF + + Y R L+MGCR +ELD DG D P++
Sbjct: 319 PDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVI 378
Query: 359 CNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLY 418
+ + +TT + F V+ I + AFVASEYP+IL + +HCS+ QQ+ MAQ KKV G+ L
Sbjct: 379 YHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLL 438
Query: 419 TEAPLPSESYLPSPEKLKRMIIVKGKKL 446
T+ S LPSP +LKR I++K KKL
Sbjct: 439 TKPVEISADGLPSPNQLKRKILIKHKKL 466
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 184 bits (468), Expect = 3e-46
Identities = 109/283 (38%), Positives = 160/283 (56%), Gaps = 15/283 (5%)
Query: 454 EGEVTDEDEEAEMS-RRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYW 512
E E DE+EE + ++ + D ++ E+S LV+ + V+++ FE + K +
Sbjct: 556 EDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF 615
Query: 513 EMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMN 572
EM SF ET+A + P +FV YNK+ LSRIYP R+DSSN PQ FWN GCQ+VA+N
Sbjct: 616 EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALN 675
Query: 573 FQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISG 632
FQT M L+ G F NG GY+L+P MR F T+ I+ G+ AL +K+ISG
Sbjct: 676 FQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISG 735
Query: 633 QNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ-RTKTVQQNSDNPIFD-ETFEF-QVN 689
Q K + YV +++ G+P D + RT+T Q NS NP++D E F+F +V
Sbjct: 736 QFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVV 787
Query: 690 LPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRS 732
LP LA +R ++ G +F+G +P ++ GY +V LR+
Sbjct: 788 LPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRN 827
Score = 153 bits (387), Expect = 7e-37
Identities = 128/424 (30%), Positives = 202/424 (47%), Gaps = 44/424 (10%)
Query: 54 DLEKAKLDISAIKEIRLGKNTETFRNN--------GLADQICEDCAFSILHGE---NYES 102
++E LDIS+I++ R G+ ++ G D E+ +++ G N
Sbjct: 58 NMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVF 117
Query: 103 LDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIML 162
L+ +A D A +W L L QN R +L+ + + N
Sbjct: 118 LNFMAVQDDTAKVWSEELFKLAMNILA--------QNASRNTFLRKAYTKLKLQVN---- 165
Query: 163 EDTSV---ELIKQLNPTLKEAKIRLKFKEIQKSK-EKLTTRVTEEEFCEAFC-ELCTRPE 217
+D + ++K + K + L+ ++ ++ E + E E F +LC RP+
Sbjct: 166 QDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPD 225
Query: 218 VYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDI--------IRRYELSEEG 268
+ +L++I +K K YL LM F+ +Q + E + + I +YE +++
Sbjct: 226 IDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQF 285
Query: 269 RQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPA 328
++ ++++GF++YL E I E ++ DMTQPLS Y+IN+SHNTYL Q G +
Sbjct: 286 LERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTS 345
Query: 329 DINGYIRALKMGCRSVELDVSDG--SDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASE 386
+ Y +AL GCR VELDV G + EP + + MTT V R V+E I + AF S
Sbjct: 346 SVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSP 405
Query: 387 YPLILCLGNHC-SLPQQKVMAQQMKKVFGNKLYTEA----PLPSESYLPSPEKLKRMIIV 441
YP+IL NH S QQ MA+ + +FG+ L E PL LPSP+ L I+V
Sbjct: 406 YPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILV 465
Query: 442 KGKK 445
K KK
Sbjct: 466 KNKK 469
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 162 bits (411), Expect = 1e-39
Identities = 86/221 (38%), Positives = 134/221 (60%), Gaps = 11/221 (4%)
Query: 232 LDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSE--CD 289
L ND ++ + E H T D L II+++E S +G ++ +GF ++L+ E
Sbjct: 1327 LQLNDFLVNCQGE----HCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFAS 1382
Query: 290 IFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVS 349
D Q+ + +++ PLS+YYI +SHNTYL Q +G + + Y + L GCRSVELD
Sbjct: 1383 KNDESQENI-KELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCW 1441
Query: 350 DGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQM 409
DG D PI+ + + +TT + F+ V+E I++ AF+ S+ P+I+ + NHCSLPQQ+ MA+
Sbjct: 1442 DGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIF 1501
Query: 410 KKVFGNKLYT----EAPLPSESYLPSPEKLKRMIIVKGKKL 446
K VFG KL T E + LPSP++L++ +++K KKL
Sbjct: 1502 KTVFGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKL 1542
Score = 145 bits (365), Expect = 2e-34
Identities = 82/261 (31%), Positives = 135/261 (51%), Gaps = 13/261 (4%)
Query: 506 MKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCG 565
+++ + + S +E A R+ Y + + L R YP+A RIDSSN NP FW G
Sbjct: 1749 IRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHG 1808
Query: 566 CQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDE----VSYFSANTKGILPGVS 621
Q+VA+N+QT + L+ F NGGCGYVL+P ++ D+ FS + L +
Sbjct: 1809 IQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERD-LDSMD 1867
Query: 622 PLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFD 681
P + I+SGQN C + P + +++ G+P D RTK + +N+ NP+++
Sbjct: 1868 PAVYSLTIVSGQN------VCPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWN 1921
Query: 682 ETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHV 741
E F F V+ +L +RF V++++ Q IP + L+ GYRH+ LR+ +++E
Sbjct: 1922 EQFLFHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEIS 1979
Query: 742 TLFVHIAITNRSGGGKAQKRS 762
+LF++ + G S
Sbjct: 1980 SLFINSRRMEENSSGNTMSAS 2000
>gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens]
Length = 858
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 2/77 (2%)
Query: 613 TKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQ 672
T I ++ +H+ I+ G N P P G D +D +V E H +D +++ V
Sbjct: 689 TVRIFSELNSTEMHLIIVRGMNLPAPPGVTP--DDLDAFVRFEFHYPNSDQAQKSKTAVV 746
Query: 673 QNSDNPIFDETFEFQVN 689
+N+++P FD+ F+ +N
Sbjct: 747 KNTNSPEFDQLFKLNIN 763
>gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens]
Length = 749
Score = 42.7 bits (99), Expect = 0.002
Identities = 25/80 (31%), Positives = 44/80 (55%), Gaps = 5/80 (6%)
Query: 646 DVIDPYVCIEIHGIPADCSEQRTKTVQQNSD-NPIFDETFEFQVNLPELAMIRFVVLDDD 704
D DPYV + I P + R +T N+D NP+++ETFEF ++ + ++ ++D +
Sbjct: 40 DTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDAN 95
Query: 705 YIGDEFIGQYTIPFECLQPG 724
Y+ DE +G T ++ G
Sbjct: 96 YVMDETLGTATFTVSSMKVG 115
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 16/98 (16%)
Query: 649 DPYVCIEIHGIPADCSEQRTKT-VQQNSDNPIFDETFEFQ-VNLPELA--MIRFVVLDDD 704
DPYV ++H +P C + KT Q+N+ NP+++E + + ++ ++R V D+D
Sbjct: 126 DPYV--KLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDED 183
Query: 705 YIG-DEFIGQYTIPFECLQPGY---------RHVPLRS 732
+ +EFIG+ +P L+P R VPL S
Sbjct: 184 KLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLAS 221
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 41.6 bits (96), Expect = 0.004
Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 26/122 (21%)
Query: 619 GVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNP 678
GV L +I+ Q P G C DPY + + G P ++TK V++ ++NP
Sbjct: 141 GVVCHKLATRIVECQGLPIVNGQC------DPYATVTLAG-PFRSEAKKTK-VKRKTNNP 192
Query: 679 IFDETFEFQVNLP----ELAMIRFVVLDDDYI--------------GDEFIGQYTIPFEC 720
FDE F F+V P + + F D D + GDEF+G+ IP +
Sbjct: 193 QFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKV 252
Query: 721 LQ 722
L+
Sbjct: 253 LR 254
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/86 (30%), Positives = 48/86 (55%), Gaps = 4/86 (4%)
Query: 645 GDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFV--VLD 702
G + DPYV I + +++T T+++N+ NP ++E+F F+V ++ ++ V VLD
Sbjct: 306 GGLSDPYVKIHLMQNGKRLKKKKT-TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLD 364
Query: 703 DDYIG-DEFIGQYTIPFECLQPGYRH 727
D IG ++ IG+ + + RH
Sbjct: 365 YDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 35.0 bits (79), Expect = 0.35
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 10/104 (9%)
Query: 625 LHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETF 684
L + II P A G DPYV + + +P + TK V + + NP+F+E F
Sbjct: 159 LLVGIIQAAELP----ALDMGGTSDPYVKVFL--LPDKKKKFETK-VHRKTLNPVFNEQF 211
Query: 685 EFQVNLPEL---AMIRFVVLDDDYIGDEFIGQYTIPFECLQPGY 725
F+V EL ++ V D + + IG++ +P + G+
Sbjct: 212 TFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/86 (30%), Positives = 48/86 (55%), Gaps = 4/86 (4%)
Query: 645 GDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFV--VLD 702
G + DPYV I + +++T T+++N+ NP ++E+F F+V ++ ++ V VLD
Sbjct: 306 GGLSDPYVKIHLMQNGKRLKKKKT-TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLD 364
Query: 703 DDYIG-DEFIGQYTIPFECLQPGYRH 727
D IG ++ IG+ + + RH
Sbjct: 365 YDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 35.0 bits (79), Expect = 0.35
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 10/104 (9%)
Query: 625 LHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETF 684
L + II P A G DPYV + + +P + TK V + + NP+F+E F
Sbjct: 159 LLVGIIQAAELP----ALDMGGTSDPYVKVFL--LPDKKKKFETK-VHRKTLNPVFNEQF 211
Query: 685 EFQVNLPEL---AMIRFVVLDDDYIGDEFIGQYTIPFECLQPGY 725
F+V EL ++ V D + + IG++ +P + G+
Sbjct: 212 TFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 40.0 bits (92), Expect = 0.011
Identities = 26/86 (30%), Positives = 48/86 (55%), Gaps = 4/86 (4%)
Query: 645 GDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFV--VLD 702
G + DPYV I + +++T T+++N+ NP ++E+F F+V ++ ++ V VLD
Sbjct: 306 GGLSDPYVKIHLMQNGKRLKKKKT-TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLD 364
Query: 703 DDYIG-DEFIGQYTIPFECLQPGYRH 727
D IG ++ IG+ + + RH
Sbjct: 365 YDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 35.0 bits (79), Expect = 0.35
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 10/104 (9%)
Query: 625 LHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETF 684
L + II P A G DPYV + + +P + TK V + + NP+F+E F
Sbjct: 159 LLVGIIQAAELP----ALDMGGTSDPYVKVFL--LPDKKKKFETK-VHRKTLNPVFNEQF 211
Query: 685 EFQVNLPEL---AMIRFVVLDDDYIGDEFIGQYTIPFECLQPGY 725
F+V EL ++ V D + + IG++ +P + G+
Sbjct: 212 TFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,909,914
Number of Sequences: 37866
Number of extensions: 1658999
Number of successful extensions: 4795
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 60
Number of HSP's that attempted gapping in prelim test: 4582
Number of HSP's gapped (non-prelim): 151
length of query: 997
length of database: 18,247,518
effective HSP length: 112
effective length of query: 885
effective length of database: 14,006,526
effective search space: 12395775510
effective search space used: 12395775510
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.