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Search of human proteins with 167555106
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167555106 centlein isoform 2 [Homo sapiens]
(391 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167555106 centlein isoform 2 [Homo sapiens] 758 0.0
gi|110815815 centlein isoform 1 [Homo sapiens] 740 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 70 4e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 69 6e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 69 9e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 67 2e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 67 2e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 67 2e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 67 2e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 66 5e-11
gi|156104908 myosin heavy chain 6 [Homo sapiens] 66 5e-11
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 65 8e-11
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 64 2e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 64 2e-10
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 64 3e-10
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 64 3e-10
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 62 9e-10
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 62 9e-10
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 62 1e-09
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 61 2e-09
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 61 2e-09
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 61 2e-09
gi|31982906 cingulin-like 1 [Homo sapiens] 61 2e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 61 2e-09
gi|42794779 myosin 18A isoform b [Homo sapiens] 61 2e-09
gi|28416946 myosin 18A isoform a [Homo sapiens] 61 2e-09
gi|45505178 cancer antigen 1 [Homo sapiens] 60 3e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 60 3e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 60 3e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 60 3e-09
>gi|167555106 centlein isoform 2 [Homo sapiens]
Length = 391
Score = 758 bits (1957), Expect = 0.0
Identities = 391/391 (100%), Positives = 391/391 (100%)
Query: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE
Sbjct: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
Query: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ
Sbjct: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
Query: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE
Sbjct: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
Query: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI
Sbjct: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
Query: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ
Sbjct: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM
Sbjct: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
Query: 361 DTQKVLRNQEDVHTAESISYQKVCFYSVIKM 391
DTQKVLRNQEDVHTAESISYQKVCFYSVIKM
Sbjct: 361 DTQKVLRNQEDVHTAESISYQKVCFYSVIKM 391
>gi|110815815 centlein isoform 1 [Homo sapiens]
Length = 1406
Score = 740 bits (1910), Expect = 0.0
Identities = 382/383 (99%), Positives = 383/383 (100%)
Query: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE
Sbjct: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
Query: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ
Sbjct: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
Query: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE
Sbjct: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
Query: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI
Sbjct: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
Query: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ
Sbjct: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM
Sbjct: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
Query: 361 DTQKVLRNQEDVHTAESISYQKV 383
DTQKVLRNQEDVHTAESISYQK+
Sbjct: 361 DTQKVLRNQEDVHTAESISYQKL 383
Score = 46.6 bits (109), Expect = 4e-05
Identities = 70/323 (21%), Positives = 138/323 (42%), Gaps = 58/323 (17%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSL---------WKRLQVTNPD 139
L G+ E+ + + E++SL EE + + V SL K+LQ +
Sbjct: 1044 LAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKN 1103
Query: 140 LTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-------DLVK 192
T E KQ S K K E+L K+ I+E ++ S ++++I DL
Sbjct: 1104 ATN------ELTKQSSNVKTLK-FELL-AKEEHIKEMHEKISRMERDITMKRHLIEDLKF 1155
Query: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK----------N 242
R+ E N + +L+KK K ++E + K + + +++ + +K
Sbjct: 1156 RQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQK 1215
Query: 243 LEEENKKLSTRCTDLLNDLEKLRKQEA--------HLRKEKYSTDAKIKTFEDNLIEARK 294
+EE +K + T L++ + + A L++ ++ ++ + L+ A +
Sbjct: 1216 SKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANE 1275
Query: 295 EVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYK-----QNSTHTAQQA 349
+VE + AL+ +L N D+ +VR++++EL+ + K + STH AQ
Sbjct: 1276 KVEEFTTFVKALAKELQN----------DVHVVRRQIRELKKMKKNRDACKTSTHKAQTL 1325
Query: 350 ELIQQLQVLNMDTQKVLRNQEDV 372
L + D +++L ++ V
Sbjct: 1326 -AASILNISRSDLEEILDTEDQV 1347
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/226 (19%), Positives = 99/226 (43%), Gaps = 18/226 (7%)
Query: 169 KDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKEC 228
K+AK F+++ +++ + V ++ ++ ++ S +++ ++
Sbjct: 938 KNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSV 997
Query: 229 VQNKEEQNRLVIKNLEEENKKL-------STRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
+QN ++ L +K +E N+KL R ++KL A LRKEK K
Sbjct: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Query: 282 IKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQN-LYKQ 340
+++ + A + +V+ + SL S D+++ ++ +L+ N L KQ
Sbjct: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSM------DLEMKQLQYKLKNATNELTKQ 1111
Query: 341 NSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV----HTAESISYQK 382
+S + EL+ + + + +K+ R + D+ H E + +++
Sbjct: 1112 SSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQ 1157
Score = 39.7 bits (91), Expect = 0.005
Identities = 62/306 (20%), Positives = 135/306 (44%), Gaps = 58/306 (18%)
Query: 95 EEAMVTRTQLLEEELSSLK----------EELALCQADKEFVWSLWKRLQVTNPDLTQVV 144
+E M+ + L EEEL LK +EL C A++ ++L + D
Sbjct: 623 QELMIQKMNL-EEELDELKVHISIDKAAIQELNRCVAERRE-----EQLFRSGEDDEVKR 676
Query: 145 SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFL 204
S + K+ E +KV E+ + +++ FE+R LK+ L+K EN FL
Sbjct: 677 STPEKNGKEMLEQTLQKVTEL----ENRLKSFEKRSRKLKEGNKKLMK-------ENDFL 725
Query: 205 RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
+ S L+++ +D K+ ++ ++ K++E+EN +L + ++L ++ L
Sbjct: 726 K---SLLKQQQEDTETREKELEQIIKGS--------KDVEKENTELQVKISELETEVTSL 774
Query: 265 RKQEAH---LRKEKYSTDAKIKTFEDNLIEARKE---VEVSQSKYNALSLQLSNKQTELI 318
R+Q A LR E ++ + A+ E ++V +Y+ ++ + +
Sbjct: 775 RRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDC-KTTMTKVKFKAA 833
Query: 319 QKDMDI----TLVRKELQELQNLYKQ---------NSTHTAQQAELIQQLQVLNMDTQKV 365
+K+ + T++ ++ + N+++ + + + +A+ Q L + ++T +
Sbjct: 834 KKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQK 893
Query: 366 LRNQED 371
+ ED
Sbjct: 894 ISPTED 899
Score = 29.6 bits (65), Expect = 4.9
Identities = 44/239 (18%), Positives = 102/239 (42%), Gaps = 37/239 (15%)
Query: 175 EFEQRESVLKQEINDLVKRKIAVDEENAFLRK---EFSDLEKKFKDKSQEIKDTKECVQN 231
E + +E +K+ + K EE LRK + +LEK + KSQE + ++ +
Sbjct: 502 EGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEK 561
Query: 232 KEEQNRLVIKNLEEENKKL-----STRCTDLLN----DLEKLRKQE--------AHLRKE 274
++E+ +++ N ++L + T++ D ++LR+++ A+ ++E
Sbjct: 562 RKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRE 621
Query: 275 KYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK----- 329
+ E+ L E + + + ++ L+ ++ ++ E + + + V++
Sbjct: 622 NQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK 681
Query: 330 -----------ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLR-NQEDVHTAE 376
++ EL+N K + + E ++L N + +L+ QED T E
Sbjct: 682 NGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETRE 740
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 69.7 bits (169), Expect = 4e-12
Identities = 79/314 (25%), Positives = 144/314 (45%), Gaps = 45/314 (14%)
Query: 85 GSRRLEGISVEEAMVTRTQLLEEELSS-------LKEELALCQADKEFVWSLWKRLQVTN 137
G + + S +E+ +T+ L++ELS +KEEL + K + SL K+L N
Sbjct: 1327 GGNQQQAASEKESCITQ---LKKELSENINAVTLMKEEL---KEKKVEISSLSKQLTDLN 1380
Query: 138 PDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAV 197
L +SL EK+ + + RK Q + K + +Q + L +++ L K KI+
Sbjct: 1381 VQLQNSISL---SEKEAAISSLRK-----QYDEEKCELLDQVQD-LSFKVDTLSKEKISA 1431
Query: 198 DEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQ-----------NKEEQNRLVIKNLEEE 246
E+ +FS+ +KK + + + ++T + +Q K+EQ L+ + L+++
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 247 NKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNAL 306
NK+ ++ +D K+ K+E++L E S A+I ED++ + E+E
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Query: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNL--YKQNSTHTAQQAELIQQLQVLNMDTQK 364
+ Q + EL+QK LQ Q L K N A++ L + QV +M +
Sbjct: 1552 NQQKDIEHKELVQK----------LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL 1601
Query: 365 VLRNQEDVHTAESI 378
+ +E H S+
Sbjct: 1602 ETKKKELEHVNLSV 1615
Score = 53.1 bits (126), Expect = 4e-07
Identities = 68/292 (23%), Positives = 130/292 (44%), Gaps = 41/292 (14%)
Query: 103 QLLEEELSSLKEELA-LCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK--- 158
++ EEE++ L+ + + +E K + +L + +S + E+ + + K
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR-------KIAVDEENAFLRKEFSDL 211
D ++ I + + + +Q S +KQE+ D++K+ K+ E RKE +L
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE-QEL 496
Query: 212 EKKFKDKSQEIKDTKECV------------QNKEEQNRLVIKNLEEENKKLSTRCTDLLN 259
KK + + +E ++ + Q KE+Q L ++ LE + K + T + L
Sbjct: 497 TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR 556
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL-SNKQTELI 318
DL+ QEA E Y T +I E +L ++ +E +QSK A+ L+ NK + I
Sbjct: 557 DLQ----QEA----ETYRT--RILELESSLEKSLQE-NKNQSKDLAVHLEAEKNKHNKEI 605
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQE 370
+V K EL++L Q ++ ++++Q M+ + QE
Sbjct: 606 -----TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE 652
Score = 53.1 bits (126), Expect = 4e-07
Identities = 56/294 (19%), Positives = 138/294 (46%), Gaps = 45/294 (15%)
Query: 113 KEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA--KDRKVL---EILQ 167
K EL + ++ +W+ ++LQV + + E+ +Q+ E KD++++ I +
Sbjct: 613 KTELESLKHQQDALWT--EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 168 VKDAKIQEFEQRESVLKQ---EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
+ + +++ + +++ L+ E+++++K + ++EE + L+ + ++++ + K E K+
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ-EAHLRK---------- 273
+ ++Q +IK E ++ D +N LE L K+ + HL++
Sbjct: 731 ------HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA 784
Query: 274 -------EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
E AK+ F+ ++ + A QL+ Q +L+ + + L
Sbjct: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTK-------AYEEQLAQLQQKLLDLETERIL 837
Query: 327 VRKELQELQNLYKQNST----HTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE 376
+ K++ E++ K T H Q +L+QQL+ N + ++ +++ V+ ++
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891
Score = 51.6 bits (122), Expect = 1e-06
Identities = 72/337 (21%), Positives = 144/337 (42%), Gaps = 68/337 (20%)
Query: 101 RTQLLEEELSSLKE----ELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSE 156
+ +LL++E KE L L Q +K+F + + Q + ++ VS + +K++ E
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 157 AK-------------------DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAV 197
+ +++ E+ ++ + ++QE EQ + LKQ+I K +
Sbjct: 1031 SLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEM 1090
Query: 198 DEENAFLRKE-------FSDLEKKFKDKSQ-------------------EIKDTKECVQN 231
++E +L++E ++L+++ K KS E+ K +N
Sbjct: 1091 NKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN 1150
Query: 232 KEEQNRLV-IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLI 290
Q +LV +K L EE+K+ + T KL+ + + K S + K+ ED +
Sbjct: 1151 TFLQEQLVELKMLAEEDKRKVSELT------SKLKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Query: 291 EARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL-----YKQNSTHT 345
E +K S+ A+ L + K+TE + + L+ + + + Q+ T
Sbjct: 1205 EFKK-----LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 346 AQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
++A LI+ V ++ Q LR + +IS+Q+
Sbjct: 1260 VKEALLIKTCTVSELEAQ--LRQLTEEQNTLNISFQQ 1294
Score = 48.9 bits (115), Expect = 8e-06
Identities = 71/286 (24%), Positives = 125/286 (43%), Gaps = 52/286 (18%)
Query: 106 EEELSSLKEELALCQADKEFVWS-LWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+E + S KE+ L ++KE + L +RLQ E EK K K
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQ--------------ELEKIKDLHMAEKTKL 344
Query: 165 ILQVKDAK--IQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI 222
I Q++DAK I++ EQ + ++ E + + + EE E + L + K + +
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE------EIAQLRSRIKQMTTQG 398
Query: 223 KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKI 282
++ +E KE+ R + LE K LST +K E RK K D +I
Sbjct: 399 EELRE---QKEKSERAAFEELE---KALSTA-----------QKTEEARRKLKAEMDEQI 441
Query: 283 KTFE----DNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
KT E + I ++E+ + + + + S +Q +QK + L RKE Q L
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE----QELT 497
Query: 339 KQNSTHTAQQAELIQQLQV-LNMDTQKVLRNQEDVHTAESISYQKV 383
K+ T ++ E +Q++V L + L+ ++ ES++ +++
Sbjct: 498 KKLQT---REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
Score = 48.1 bits (113), Expect = 1e-05
Identities = 77/347 (22%), Positives = 140/347 (40%), Gaps = 61/347 (17%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQADKEFVWS--LWKRLQVTNPDLTQVVSLVVERE 151
++E + Q E+E++ LK+++ L +KE + W + + D T ++ + E+
Sbjct: 1058 LQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT--LNELQEQL 1115
Query: 152 KQKS---------EAKDRKVLEILQV---KDAKIQEFEQRESVL--------KQEINDLV 191
KQKS E K + LE L+V K K F Q + V K+++++L
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 192 KRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKE--------CVQNKE-----EQNRL 238
+ DEE L+ K +DKS E K E C + E + N L
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 239 VIKNLEEENKKLST------------------RCT--DLLNDLEKLRKQEAHLRKEKYST 278
+ + + N LS CT +L L +L +++ L
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQN-- 336
+++ E+ + + ++E ++ AL + N+Q +K+ IT ++KEL E N
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
Query: 337 --LYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQ 381
+ ++ + + L +QL LN+ Q + E S+ Q
Sbjct: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/222 (20%), Positives = 101/222 (45%), Gaps = 13/222 (5%)
Query: 160 RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
+K+L++ + ++ + E+ K +L KI V + L K+ S++E+K K +
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLT 885
Query: 220 QEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTR-----CTDLLNDLEKLRKQEAHLRKE 274
Q + E ++EQ + ++ +E+EN L R ++L ++ H+ E
Sbjct: 886 QVYESKLEDGNKEQEQTKQIL--VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 275 KYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+Y T K K E + + +++ + Q L +L +++ +L +K+++ T + +E
Sbjct: 944 EYET--KFKNQEKKMEKVKQKAKEMQ---ETLKKKLLDQEAKL-KKELENTALELSQKEK 997
Query: 335 QNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE 376
Q K A A + + L + ++ + + +VH E
Sbjct: 998 QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE 1039
Score = 43.5 bits (101), Expect = 3e-04
Identities = 57/318 (17%), Positives = 131/318 (41%), Gaps = 61/318 (19%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELA--LCQADKEFVWSLWKRLQVTNPDLTQVVSLVVER 150
S EE + +L E+EL+ ++EL L ++EF + L+ + + ++ E+
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ---EK 529
Query: 151 EKQKSEAKDRKVLE---ILQVKDAKIQEFEQR---------------ESVLKQEINDLVK 192
E+Q+S A + L+ IL + K+++ +Q E L++ N
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD 589
Query: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKE------------------------C 228
+ ++ E KE + + +K K + + +K ++ C
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 229 VQNKE----EQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
Q KE ++ + ++EE N+K + +LE L + + + K ++ + ++
Sbjct: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV 709
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE------LQELQNLY 338
+D + ++E+E + +Q + I K+ ++++ R E + +L+ L
Sbjct: 710 LKDQTDKMKQELEAKMDEQK----NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765
Query: 339 KQNSTHTAQQAELIQQLQ 356
K+ H + ++ L+
Sbjct: 766 KERDKHLKEHQAHVENLE 783
Score = 39.7 bits (91), Expect = 0.005
Identities = 43/215 (20%), Positives = 101/215 (46%), Gaps = 11/215 (5%)
Query: 147 VVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
V++ Q+ + + +++++ LQ +E + R +++I L + ++ E +K
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
E + K K +E+K ++ ++++ +K E+ K++ LL+ +E+ +
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ--KIAAIKKQLLSQMEEKEE 1664
Query: 267 Q-----EAHLRKEKYSTDAKIKTFEDNLIEAR-KEVEVSQSKYNALSLQLSNKQTELIQK 320
Q E+HL + +T + + E +++E + K VE SQS+ + N Q+
Sbjct: 1665 QYKKGTESHL--SELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQE 1722
Query: 321 DMDIT-LVRKELQELQNLYKQNSTHTAQQAELIQQ 354
+ D V+K +E ++ ++N T + + + Q
Sbjct: 1723 EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757
Score = 38.5 bits (88), Expect = 0.011
Identities = 43/192 (22%), Positives = 85/192 (44%), Gaps = 14/192 (7%)
Query: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
S ++ + NDL + + E L KE L+K + +E + E ++ + +Q R
Sbjct: 1919 SNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER--E 1976
Query: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKE-VEVS 299
+ +++E + L + L L +R+ L +++ + IK + E E +E
Sbjct: 1977 EKIKQEQEDLELKHNSTLKQL--MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESH 2034
Query: 300 QSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLN 359
Q + N L +++ +KD D+ K +E+ L + TA+ +L QL+ L
Sbjct: 2035 QEETNQLLKKIA-------EKDDDLKRTAKRYEEI--LDAREEEMTAKVRDLQTQLEELQ 2085
Query: 360 MDTQKVLRNQED 371
Q+ L +E+
Sbjct: 2086 KKYQQKLEQEEN 2097
Score = 37.0 bits (84), Expect = 0.031
Identities = 43/185 (23%), Positives = 87/185 (47%), Gaps = 20/185 (10%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E+E LK L Q +EF L ++ Q + + ++ E E + E+ + ++
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK-SQEIKD 224
L+ K A+ + +R + +EI D + ++ + L+ + +L+KK++ K QE
Sbjct: 2042 LK-KIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD--LQTQLEELQKKYQQKLEQEENP 2098
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
+ V E Q +L K T L++D KL++QE R++ ++ + ++K
Sbjct: 2099 GNDNVTIMELQTQLAQK-------------TTLISD-SKLKEQE--FREQIHNLEDRLKK 2142
Query: 285 FEDNL 289
+E N+
Sbjct: 2143 YEKNV 2147
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 69.3 bits (168), Expect = 6e-12
Identities = 78/300 (26%), Positives = 134/300 (44%), Gaps = 51/300 (17%)
Query: 87 RRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL---TQV 143
R +E + + + QL +EL S KE+L + + +RL+V+ L Q
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
Query: 144 VSLVVEREKQK-----SEAKD--------RKVLEILQVKDAKIQEFEQRESVLKQEINDL 190
+ +E +K SE +D +K LE L++ ++++ E+ L+QE + L
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Query: 191 VKRKIAVDEENAFLRKE--------------FSDLEKKFKDKSQEIKDTKE-CVQNK--E 233
K K +++EN LR++ +LEK+ K S+EI KE CV+ K E
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 234 EQNRLVIKNLEEENKKLSTRCTDLL----------NDLEKLRKQ-------EAHLRKEKY 276
++N+ ++K + K L T DL+ NDLEKL + + L ++
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 277 STDAKIKTFEDNLIEA-RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ 335
STD + K E L +K +E+ + K AL +L Q ++ V+K + L+
Sbjct: 948 STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007
Score = 54.7 bits (130), Expect = 1e-07
Identities = 74/295 (25%), Positives = 136/295 (46%), Gaps = 44/295 (14%)
Query: 96 EAMVTRTQLLE--EELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
E+ T +LL+ + L ++ A QA+K+ + + K+L+ N +L Q L ++R+
Sbjct: 1032 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL-QAQILALQRQTV 1090
Query: 154 KSEAKDRKVLEILQVKDAKIQEFE-----QRESVLKQEINDLVKRKIAVDEENAFLRKEF 208
+ ++ LQ ++AK+Q Q S++ Q L+++ +++ EN + KE
Sbjct: 1091 SLQEQNTT----LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS-SLENENESVIKER 1145
Query: 209 SDLEK------KFKDKSQEIKDTK----ECVQNKEEQNRLVIKNLEEENKKLSTRCTDLL 258
DL+ K +K + + + + E + +K + KNLE E++ L R LL
Sbjct: 1146 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1205
Query: 259 N------DLEKLRKQEAH---LRKEKYSTDA----KIKTFEDNL----IEARKEVEVSQS 301
DLEK+ K E L + + T A K+ D L + KE EV Q+
Sbjct: 1206 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
Query: 302 KYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQ 356
+ L L+N + E + + + + ++++ Q+L ST Q EL+ QL+
Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLK 1316
Score = 53.1 bits (126), Expect = 4e-07
Identities = 74/333 (22%), Positives = 138/333 (41%), Gaps = 47/333 (14%)
Query: 51 DESDK-----IWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEG---ISVEEAMV-TR 101
DE D+ I + EE G P ++ A +P S G +R E +SVE A +
Sbjct: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP--GMKRTESRQHLSVELADAKAK 259
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
+ L +EL E+L C+ + E + KRLQ N +L +S R
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS---------DARSARMYRD 310
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
L+ L+ K ++ + E S K+ ++D+ K V+E K+ +Q
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE---------------LKEDNQV 355
Query: 222 IKDTKECVQNKEEQNRL---VIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
+ +TK ++++ E R + LE+EN +L + D+ + + RK+ L +E +
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
+ K D + E+E + +++ +E QK + + L L
Sbjct: 416 EMAQKQSMDESLHLGWELE---------QISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
+N + T EL + + + K+L+ +++
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499
Score = 47.0 bits (110), Expect = 3e-05
Identities = 61/270 (22%), Positives = 114/270 (42%), Gaps = 54/270 (20%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R + LE EL L++E L Q ++TN +T +E+E + E ++R
Sbjct: 626 RAEELENELHHLEKENELLQK------------KITNLKITCEKIEALEQENSELERENR 673
Query: 161 KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE-------- 212
K+ + L F+ L ++ L K +DEEN LR+ L+
Sbjct: 674 KLKKTLD-------SFKN----LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 213 -----KKFKDKSQEIKDTKECVQ---NKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
K+ + + +++K E ++ K E+ + + L+ EN++L L N +K+
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ---KTLENSNKKI 779
Query: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----------EVEVSQSKYNALSLQLSNK 313
++ E+ L+ + K E+ I +++ E E SQ + + L+ NK
Sbjct: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
Query: 314 QTELIQKDMDITLVRKELQELQNLYKQNST 343
+ + D TL + ++ NL K+N T
Sbjct: 840 RLRQQAEIKDTTLEENNV-KIGNLEKENKT 868
Score = 42.4 bits (98), Expect = 7e-04
Identities = 63/302 (20%), Positives = 133/302 (44%), Gaps = 30/302 (9%)
Query: 73 APAHAPLLSAPMGSRRLEGISVEEAM---VTRTQLLEEELSSLKEELALCQADKEFVWSL 129
A H + M +++E + +EE M + + Q ++E L L EL E +
Sbjct: 389 AKLHDMEMERDMDRKKIEEL-MEENMTLEMAQKQSMDESLH-LGWELEQISRTSELSEAP 446
Query: 130 WKRLQVTNPDLTQVVSLVVEREKQ---KSEAKDRKVLEILQVKDAKIQEFEQRESVLKQE 186
K L +LT L +E E Q K+ + R ++ ++ +KI + E+ L ++
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 187 INDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEE 246
+ ++++ +I ++++ + + KD +E ++ ++ E + IK LE+E
Sbjct: 507 V-EILENEIVQEKQS------LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559
Query: 247 NKKLSTRCTDLLN--------DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEV 298
N+ L+ + L ++ + K+ L + T +K+ E + +KE+E
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
Query: 299 SQSKYNAL-----SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQ 353
+ K L K+ EL+QK IT ++ ++++ L ++NS + +L +
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQK--KITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 354 QL 355
L
Sbjct: 678 TL 679
Score = 30.0 bits (66), Expect = 3.7
Identities = 54/226 (23%), Positives = 94/226 (41%), Gaps = 35/226 (15%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKD- 159
+ +LL E +S E L + S K L+V + DL + ++ KQK + +D
Sbjct: 1161 KLELLHERQASEYESLISKHGTLK---SAHKNLEVEHRDLEDRYNQLL---KQKGQLEDL 1214
Query: 160 RKVLEILQVKDAKIQEFEQRESV-------------LKQEINDLVKRK--IAVDEENAFL 204
K+L++ Q K + E + E+V L + L+K + D +N
Sbjct: 1215 EKMLKVEQEK--MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1272
Query: 205 RKEFSDLEK--------KFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTD 256
S LE+ K K++ Q++ T + N+ E + NLEEEN+ L +
Sbjct: 1273 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1332
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSK 302
L+ L +Q + K + + + D L E R++ E + K
Sbjct: 1333 LMLQNRTLLEQN---MESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 68.6 bits (166), Expect = 9e-12
Identities = 78/301 (25%), Positives = 134/301 (44%), Gaps = 52/301 (17%)
Query: 87 RRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL---TQV 143
R +E + + + QL +EL S KE+L + + +RL+V+ L Q
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
Query: 144 VSLVVEREKQK-----SEAKD--------RKVLEILQVKDAKIQEFEQRESVLKQEINDL 190
+ +E +K SE +D +K LE L++ ++++ E+ L+QE + L
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Query: 191 VKRKIAVDEENAFLRKE--------------FSDLEKKFKDKSQEIKDTKE-CVQNK--E 233
K K +++EN LR++ +LEK+ K S+EI KE CV+ K E
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 234 EQNRLVIKNLEEENKKLSTRCTDLL----------NDLEKLR--------KQEAHLRKEK 275
++N+ ++K + K L T DL+ NDLEKL +E L E+
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 276 YSTDAKIKTFEDNLIEA-RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+ D++ K E L +K +E+ + K AL +L Q ++ V+K + L
Sbjct: 948 STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1007
Query: 335 Q 335
+
Sbjct: 1008 K 1008
Score = 54.7 bits (130), Expect = 1e-07
Identities = 74/295 (25%), Positives = 136/295 (46%), Gaps = 44/295 (14%)
Query: 96 EAMVTRTQLLE--EELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
E+ T +LL+ + L ++ A QA+K+ + + K+L+ N +L Q L ++R+
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL-QAQILALQRQTV 1091
Query: 154 KSEAKDRKVLEILQVKDAKIQEFE-----QRESVLKQEINDLVKRKIAVDEENAFLRKEF 208
+ ++ LQ ++AK+Q Q S++ Q L+++ +++ EN + KE
Sbjct: 1092 SLQEQNTT----LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS-SLENENESVIKER 1146
Query: 209 SDLEK------KFKDKSQEIKDTK----ECVQNKEEQNRLVIKNLEEENKKLSTRCTDLL 258
DL+ K +K + + + + E + +K + KNLE E++ L R LL
Sbjct: 1147 EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLL 1206
Query: 259 N------DLEKLRKQEAH---LRKEKYSTDA----KIKTFEDNL----IEARKEVEVSQS 301
DLEK+ K E L + + T A K+ D L + KE EV Q+
Sbjct: 1207 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1266
Query: 302 KYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQ 356
+ L L+N + E + + + + ++++ Q+L ST Q EL+ QL+
Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLK 1317
Score = 53.1 bits (126), Expect = 4e-07
Identities = 74/333 (22%), Positives = 138/333 (41%), Gaps = 47/333 (14%)
Query: 51 DESDK-----IWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEG---ISVEEAMV-TR 101
DE D+ I + EE G P ++ A +P S G +R E +SVE A +
Sbjct: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP--GMKRTESRQHLSVELADAKAK 259
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
+ L +EL E+L C+ + E + KRLQ N +L +S R
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS---------DARSARMYRD 310
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
L+ L+ K ++ + E S K+ ++D+ K V+E K+ +Q
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE---------------LKEDNQV 355
Query: 222 IKDTKECVQNKEEQNRL---VIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
+ +TK ++++ E R + LE+EN +L + D+ + + RK+ L +E +
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
+ K D + E+E + +++ +E QK + + L L
Sbjct: 416 EMAQKQSMDESLHLGWELE---------QISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
+N + T EL + + + K+L+ +++
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKE 499
Score = 47.0 bits (110), Expect = 3e-05
Identities = 61/270 (22%), Positives = 114/270 (42%), Gaps = 54/270 (20%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R + LE EL L++E L Q ++TN +T +E+E + E ++R
Sbjct: 626 RAEELENELHHLEKENELLQK------------KITNLKITCEKIEALEQENSELERENR 673
Query: 161 KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE-------- 212
K+ + L F+ L ++ L K +DEEN LR+ L+
Sbjct: 674 KLKKTLD-------SFKN----LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 213 -----KKFKDKSQEIKDTKECVQ---NKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
K+ + + +++K E ++ K E+ + + L+ EN++L L N +K+
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ---KTLENSNKKI 779
Query: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARK-----------EVEVSQSKYNALSLQLSNK 313
++ E+ L+ + K E+ I +++ E E SQ + + L+ NK
Sbjct: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
Query: 314 QTELIQKDMDITLVRKELQELQNLYKQNST 343
+ + D TL + ++ NL K+N T
Sbjct: 840 RLRQQAEIKDTTLEENNV-KIGNLEKENKT 868
Score = 42.4 bits (98), Expect = 7e-04
Identities = 63/302 (20%), Positives = 133/302 (44%), Gaps = 30/302 (9%)
Query: 73 APAHAPLLSAPMGSRRLEGISVEEAM---VTRTQLLEEELSSLKEELALCQADKEFVWSL 129
A H + M +++E + +EE M + + Q ++E L L EL E +
Sbjct: 389 AKLHDMEMERDMDRKKIEEL-MEENMTLEMAQKQSMDESLH-LGWELEQISRTSELSEAP 446
Query: 130 WKRLQVTNPDLTQVVSLVVEREKQ---KSEAKDRKVLEILQVKDAKIQEFEQRESVLKQE 186
K L +LT L +E E Q K+ + R ++ ++ +KI + E+ L ++
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 187 INDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEE 246
+ ++++ +I ++++ + + KD +E ++ ++ E + IK LE+E
Sbjct: 507 V-EILENEIVQEKQS------LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQE 559
Query: 247 NKKLSTRCTDLLN--------DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEV 298
N+ L+ + L ++ + K+ L + T +K+ E + +KE+E
Sbjct: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
Query: 299 SQSKYNAL-----SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQ 353
+ K L K+ EL+QK IT ++ ++++ L ++NS + +L +
Sbjct: 620 YKEKGERAEELENELHHLEKENELLQK--KITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 354 QL 355
L
Sbjct: 678 TL 679
Score = 30.0 bits (66), Expect = 3.7
Identities = 54/226 (23%), Positives = 94/226 (41%), Gaps = 35/226 (15%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKD- 159
+ +LL E +S E L + S K L+V + DL + ++ KQK + +D
Sbjct: 1162 KLELLHERQASEYESLISKHGTLK---SAHKNLEVEHRDLEDRYNQLL---KQKGQLEDL 1215
Query: 160 RKVLEILQVKDAKIQEFEQRESV-------------LKQEINDLVKRK--IAVDEENAFL 204
K+L++ Q K + E + E+V L + L+K + D +N
Sbjct: 1216 EKMLKVEQEK--MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
Query: 205 RKEFSDLEK--------KFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTD 256
S LE+ K K++ Q++ T + N+ E + NLEEEN+ L +
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1333
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSK 302
L+ L +Q + K + + + D L E R++ E + K
Sbjct: 1334 LMLQNRTLLEQN---MESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/254 (25%), Positives = 123/254 (48%), Gaps = 22/254 (8%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 866
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 922
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 983 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 343 THTAQQAELIQQLQ 356
H + +EL +L+
Sbjct: 1031 KHESMISELEVRLK 1044
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/234 (23%), Positives = 107/234 (45%), Gaps = 22/234 (9%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
++ EK +EAK +K+ + + V D + + + +L++ I+DL +A +EE A K
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEEEKA---KN 1024
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ 267
+ L+ K + E+ E KEE++R + LE+ +KL +D + L+ Q
Sbjct: 1025 LTKLKNKHESMISEL----EVRLKKEEKSR---QELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 268 EAHLR----KEKYSTDAKIKTFEDNLIE---ARKEVEVSQSKYNALSLQLSNKQTELIQK 320
A L+ K++ A + +D + + A K++ + + L L +++ +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 321 DMDITLVRKELQELQNLYKQNSTHTAQQAEL----IQQLQVLNMDTQKVLRNQE 370
+ + +EL+ L+ + TA Q EL Q++ VL + R+ E
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/278 (19%), Positives = 118/278 (42%), Gaps = 22/278 (7%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E + L +++ Q + E V + + L + V+ + + + E + +
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD-------- 217
L V K+++ E+ + L+ ++++ ++ K ++ + L + SD +KK +D
Sbjct: 1332 LNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 218 ---KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K + K+ + Q EE+ K LE+ +L DL+ DL+ R+ ++L K+
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 275 KYSTD---AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ D A+ K + R E + +L L+ E ++ ++ K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 332 Q-ELQNLYKQ-----NSTHTAQQAELIQQLQVLNMDTQ 363
+ E+++L + H ++++ + Q+ M TQ
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Score = 46.2 bits (108), Expect = 5e-05
Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 23/192 (11%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQ---EFEQRESVLKQEINDLVKRKIAVDEENAF 203
ER++ ++EA+++ K L + + + ++ E E+ +LK E+ DLV K V +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNL------------------EE 245
L K LE + ++ ++++ ++ +Q E+ + N+ EE
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 246 ENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+ ++L + + +LE RKQ A K + +K E A K E + +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 306 LSLQLSNKQTEL 317
L Q+ + Q EL
Sbjct: 1650 LQAQMKDFQREL 1661
Score = 44.7 bits (104), Expect = 1e-04
Identities = 47/259 (18%), Positives = 108/259 (41%), Gaps = 1/259 (0%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
+ + + L+ L+ L +E+A + + L + DL + + EKQK +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ +++D Q+E K+E V +K A+DEE + ++ +K
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEMRQKHAQ 1203
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+E+ + E + + + LE+EN L+ L +++ ++ L +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL 337
+K E E +V Q++ +++ L+ + + I+ D+ + +LQ+ Q L
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 338 YKQNSTHTAQQAELIQQLQ 356
++ + + ++QL+
Sbjct: 1324 LQEETRQKLNVSTKLRQLE 1342
Score = 40.0 bits (92), Expect = 0.004
Identities = 62/287 (21%), Positives = 121/287 (42%), Gaps = 32/287 (11%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
++EEA+ + +L E LK E+ + K+ V L+ + L + E +
Sbjct: 1491 ALEEALEAKEEL-ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKT 1546
Query: 153 QKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE 212
Q E +D E+ +DAK++ +++ Q DL R +E+ L+++ + E
Sbjct: 1547 QLEELED----ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 213 KKFKDKSQEI-------KDTKECVQNKEEQNRLVIKNLEEENK---KLSTRCTDLLNDLE 262
+ +D+ ++ K + +++ E Q IK EE K KL + D +LE
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIE----------ARKEVEVSQSKY-NALSLQLS 311
R + + K K+ E +L++ ARK+ ++ + + L+ LS
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 312 NK---QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
+ Q E + + I + +EL+E Q + S + + +QL
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Score = 35.8 bits (81), Expect = 0.068
Identities = 45/252 (17%), Positives = 104/252 (41%), Gaps = 28/252 (11%)
Query: 52 ESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSS 111
E+D + + E+ + R A A L + +S A+ + LE ++
Sbjct: 1686 EADLMQLQEDLAAAER-----ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 112 LKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS-LVVEREKQKSEAKDRKVLE------ 164
L+EEL Q + E ++ R++ Q+ + L ER + R+ LE
Sbjct: 1741 LEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 165 ---ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ +++ A +F+ + L+ +I L ++ E K +KK K+ +
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 222 IKDTKECVQNKEEQN----------RLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
++D ++ + +EQ + ++ EEE+++++ L +L++ + +
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 272 RKEKYSTDAKIK 283
+E + +K++
Sbjct: 1918 GREVNALKSKLR 1929
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/254 (25%), Positives = 123/254 (48%), Gaps = 22/254 (8%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 873
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 929
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 990 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 343 THTAQQAELIQQLQ 356
H + +EL +L+
Sbjct: 1038 KHESMISELEVRLK 1051
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/234 (23%), Positives = 107/234 (45%), Gaps = 22/234 (9%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
++ EK +EAK +K+ + + V D + + + +L++ I+DL +A +EE A K
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEEEKA---KN 1031
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ 267
+ L+ K + E+ E KEE++R + LE+ +KL +D + L+ Q
Sbjct: 1032 LTKLKNKHESMISEL----EVRLKKEEKSR---QELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 268 EAHLR----KEKYSTDAKIKTFEDNLIE---ARKEVEVSQSKYNALSLQLSNKQTELIQK 320
A L+ K++ A + +D + + A K++ + + L L +++ +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 321 DMDITLVRKELQELQNLYKQNSTHTAQQAEL----IQQLQVLNMDTQKVLRNQE 370
+ + +EL+ L+ + TA Q EL Q++ VL + R+ E
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/278 (19%), Positives = 118/278 (42%), Gaps = 22/278 (7%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E + L +++ Q + E V + + L + V+ + + + E + +
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD-------- 217
L V K+++ E+ + L+ ++++ ++ K ++ + L + SD +KK +D
Sbjct: 1339 LNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 218 ---KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K + K+ + Q EE+ K LE+ +L DL+ DL+ R+ ++L K+
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 275 KYSTD---AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ D A+ K + R E + +L L+ E ++ ++ K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 332 Q-ELQNLYKQ-----NSTHTAQQAELIQQLQVLNMDTQ 363
+ E+++L + H ++++ + Q+ M TQ
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Score = 46.2 bits (108), Expect = 5e-05
Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 23/192 (11%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQ---EFEQRESVLKQEINDLVKRKIAVDEENAF 203
ER++ ++EA+++ K L + + + ++ E E+ +LK E+ DLV K V +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNL------------------EE 245
L K LE + ++ ++++ ++ +Q E+ + N+ EE
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 246 ENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+ ++L + + +LE RKQ A K + +K E A K E + +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 306 LSLQLSNKQTEL 317
L Q+ + Q EL
Sbjct: 1657 LQAQMKDFQREL 1668
Score = 44.7 bits (104), Expect = 1e-04
Identities = 47/259 (18%), Positives = 108/259 (41%), Gaps = 1/259 (0%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
+ + + L+ L+ L +E+A + + L + DL + + EKQK +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ +++D Q+E K+E V +K A+DEE + ++ +K
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEMRQKHAQ 1210
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+E+ + E + + + LE+EN L+ L +++ ++ L +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL 337
+K E E +V Q++ +++ L+ + + I+ D+ + +LQ+ Q L
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 338 YKQNSTHTAQQAELIQQLQ 356
++ + + ++QL+
Sbjct: 1331 LQEETRQKLNVSTKLRQLE 1349
Score = 40.0 bits (92), Expect = 0.004
Identities = 62/287 (21%), Positives = 121/287 (42%), Gaps = 32/287 (11%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
++EEA+ + +L E LK E+ + K+ V L+ + L + E +
Sbjct: 1498 ALEEALEAKEEL-ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKT 1553
Query: 153 QKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE 212
Q E +D E+ +DAK++ +++ Q DL R +E+ L+++ + E
Sbjct: 1554 QLEELED----ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 213 KKFKDKSQEI-------KDTKECVQNKEEQNRLVIKNLEEENK---KLSTRCTDLLNDLE 262
+ +D+ ++ K + +++ E Q IK EE K KL + D +LE
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIE----------ARKEVEVSQSKY-NALSLQLS 311
R + + K K+ E +L++ ARK+ ++ + + L+ LS
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 312 NK---QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
+ Q E + + I + +EL+E Q + S + + +QL
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Score = 35.8 bits (81), Expect = 0.068
Identities = 45/252 (17%), Positives = 104/252 (41%), Gaps = 28/252 (11%)
Query: 52 ESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSS 111
E+D + + E+ + R A A L + +S A+ + LE ++
Sbjct: 1693 EADLMQLQEDLAAAER-----ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 112 LKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS-LVVEREKQKSEAKDRKVLE------ 164
L+EEL Q + E ++ R++ Q+ + L ER + R+ LE
Sbjct: 1748 LEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 165 ---ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ +++ A +F+ + L+ +I L ++ E K +KK K+ +
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 222 IKDTKECVQNKEEQN----------RLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
++D ++ + +EQ + ++ EEE+++++ L +L++ + +
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 272 RKEKYSTDAKIK 283
+E + +K++
Sbjct: 1925 GREVNALKSKLR 1936
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/254 (25%), Positives = 123/254 (48%), Gaps = 22/254 (8%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 873
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 929
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 990 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 343 THTAQQAELIQQLQ 356
H + +EL +L+
Sbjct: 1038 KHESMISELEVRLK 1051
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/234 (23%), Positives = 107/234 (45%), Gaps = 22/234 (9%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
++ EK +EAK +K+ + + V D + + + +L++ I+DL +A +EE A K
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEEEKA---KN 1031
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ 267
+ L+ K + E+ E KEE++R + LE+ +KL +D + L+ Q
Sbjct: 1032 LTKLKNKHESMISEL----EVRLKKEEKSR---QELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 268 EAHLR----KEKYSTDAKIKTFEDNLIE---ARKEVEVSQSKYNALSLQLSNKQTELIQK 320
A L+ K++ A + +D + + A K++ + + L L +++ +
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 321 DMDITLVRKELQELQNLYKQNSTHTAQQAEL----IQQLQVLNMDTQKVLRNQE 370
+ + +EL+ L+ + TA Q EL Q++ VL + R+ E
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/278 (19%), Positives = 118/278 (42%), Gaps = 22/278 (7%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E + L +++ Q + E V + + L + V+ + + + E + +
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD-------- 217
L V K+++ E+ + L+ ++++ ++ K ++ + L + SD +KK +D
Sbjct: 1339 LNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 218 ---KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K + K+ + Q EE+ K LE+ +L DL+ DL+ R+ ++L K+
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 275 KYSTD---AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ D A+ K + R E + +L L+ E ++ ++ K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 332 Q-ELQNLYKQ-----NSTHTAQQAELIQQLQVLNMDTQ 363
+ E+++L + H ++++ + Q+ M TQ
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Score = 46.2 bits (108), Expect = 5e-05
Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 23/192 (11%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQ---EFEQRESVLKQEINDLVKRKIAVDEENAF 203
ER++ ++EA+++ K L + + + ++ E E+ +LK E+ DLV K V +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNL------------------EE 245
L K LE + ++ ++++ ++ +Q E+ + N+ EE
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 246 ENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+ ++L + + +LE RKQ A K + +K E A K E + +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 306 LSLQLSNKQTEL 317
L Q+ + Q EL
Sbjct: 1657 LQAQMKDFQREL 1668
Score = 44.7 bits (104), Expect = 1e-04
Identities = 47/259 (18%), Positives = 108/259 (41%), Gaps = 1/259 (0%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
+ + + L+ L+ L +E+A + + L + DL + + EKQK +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ +++D Q+E K+E V +K A+DEE + ++ +K
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEMRQKHAQ 1210
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+E+ + E + + + LE+EN L+ L +++ ++ L +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL 337
+K E E +V Q++ +++ L+ + + I+ D+ + +LQ+ Q L
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330
Query: 338 YKQNSTHTAQQAELIQQLQ 356
++ + + ++QL+
Sbjct: 1331 LQEETRQKLNVSTKLRQLE 1349
Score = 40.0 bits (92), Expect = 0.004
Identities = 62/287 (21%), Positives = 121/287 (42%), Gaps = 32/287 (11%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
++EEA+ + +L E LK E+ + K+ V L+ + L + E +
Sbjct: 1498 ALEEALEAKEEL-ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKT 1553
Query: 153 QKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE 212
Q E +D E+ +DAK++ +++ Q DL R +E+ L+++ + E
Sbjct: 1554 QLEELED----ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 213 KKFKDKSQEI-------KDTKECVQNKEEQNRLVIKNLEEENK---KLSTRCTDLLNDLE 262
+ +D+ ++ K + +++ E Q IK EE K KL + D +LE
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIE----------ARKEVEVSQSKY-NALSLQLS 311
R + + K K+ E +L++ ARK+ ++ + + L+ LS
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 312 NK---QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
+ Q E + + I + +EL+E Q + S + + +QL
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Score = 35.8 bits (81), Expect = 0.068
Identities = 45/252 (17%), Positives = 104/252 (41%), Gaps = 28/252 (11%)
Query: 52 ESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSS 111
E+D + + E+ + R A A L + +S A+ + LE ++
Sbjct: 1693 EADLMQLQEDLAAAER-----ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 112 LKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS-LVVEREKQKSEAKDRKVLE------ 164
L+EEL Q + E ++ R++ Q+ + L ER + R+ LE
Sbjct: 1748 LEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 165 ---ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ +++ A +F+ + L+ +I L ++ E K +KK K+ +
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 222 IKDTKECVQNKEEQN----------RLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
++D ++ + +EQ + ++ EEE+++++ L +L++ + +
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 272 RKEKYSTDAKIK 283
+E + +K++
Sbjct: 1925 GREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/254 (25%), Positives = 123/254 (48%), Gaps = 22/254 (8%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 866
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 922
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 983 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 343 THTAQQAELIQQLQ 356
H + +EL +L+
Sbjct: 1031 KHESMISELEVRLK 1044
Score = 48.5 bits (114), Expect = 1e-05
Identities = 54/234 (23%), Positives = 107/234 (45%), Gaps = 22/234 (9%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
++ EK +EAK +K+ + + V D + + + +L++ I+DL +A +EE A K
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEEEEKA---KN 1024
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ 267
+ L+ K + E+ E KEE++R + LE+ +KL +D + L+ Q
Sbjct: 1025 LTKLKNKHESMISEL----EVRLKKEEKSR---QELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 268 EAHLR----KEKYSTDAKIKTFEDNLIE---ARKEVEVSQSKYNALSLQLSNKQTELIQK 320
A L+ K++ A + +D + + A K++ + + L L +++ +
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 321 DMDITLVRKELQELQNLYKQNSTHTAQQAEL----IQQLQVLNMDTQKVLRNQE 370
+ + +EL+ L+ + TA Q EL Q++ VL + R+ E
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/278 (19%), Positives = 118/278 (42%), Gaps = 22/278 (7%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E + L +++ Q + E V + + L + V+ + + + E + +
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD-------- 217
L V K+++ E+ + L+ ++++ ++ K ++ + L + SD +KK +D
Sbjct: 1332 LNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 218 ---KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K + K+ + Q EE+ K LE+ +L DL+ DL+ R+ ++L K+
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 275 KYSTD---AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ D A+ K + R E + +L L+ E ++ ++ K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 332 Q-ELQNLYKQ-----NSTHTAQQAELIQQLQVLNMDTQ 363
+ E+++L + H ++++ + Q+ M TQ
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Score = 46.2 bits (108), Expect = 5e-05
Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 23/192 (11%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQ---EFEQRESVLKQEINDLVKRKIAVDEENAF 203
ER++ ++EA+++ K L + + + ++ E E+ +LK E+ DLV K V +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNL------------------EE 245
L K LE + ++ ++++ ++ +Q E+ + N+ EE
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 246 ENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+ ++L + + +LE RKQ A K + +K E A K E + +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 306 LSLQLSNKQTEL 317
L Q+ + Q EL
Sbjct: 1650 LQAQMKDFQREL 1661
Score = 44.7 bits (104), Expect = 1e-04
Identities = 47/259 (18%), Positives = 108/259 (41%), Gaps = 1/259 (0%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
+ + + L+ L+ L +E+A + + L + DL + + EKQK +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ +++D Q+E K+E V +K A+DEE + ++ +K
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEMRQKHAQ 1203
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+E+ + E + + + LE+EN L+ L +++ ++ L +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL 337
+K E E +V Q++ +++ L+ + + I+ D+ + +LQ+ Q L
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323
Query: 338 YKQNSTHTAQQAELIQQLQ 356
++ + + ++QL+
Sbjct: 1324 LQEETRQKLNVSTKLRQLE 1342
Score = 40.0 bits (92), Expect = 0.004
Identities = 62/287 (21%), Positives = 121/287 (42%), Gaps = 32/287 (11%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
++EEA+ + +L E LK E+ + K+ V L+ + L + E +
Sbjct: 1491 ALEEALEAKEEL-ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---EMKT 1546
Query: 153 QKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE 212
Q E +D E+ +DAK++ +++ Q DL R +E+ L+++ + E
Sbjct: 1547 QLEELED----ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 213 KKFKDKSQEI-------KDTKECVQNKEEQNRLVIKNLEEENK---KLSTRCTDLLNDLE 262
+ +D+ ++ K + +++ E Q IK EE K KL + D +LE
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIE----------ARKEVEVSQSKY-NALSLQLS 311
R + + K K+ E +L++ ARK+ ++ + + L+ LS
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 312 NK---QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
+ Q E + + I + +EL+E Q + S + + +QL
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Score = 35.8 bits (81), Expect = 0.068
Identities = 45/252 (17%), Positives = 104/252 (41%), Gaps = 28/252 (11%)
Query: 52 ESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSS 111
E+D + + E+ + R A A L + +S A+ + LE ++
Sbjct: 1686 EADLMQLQEDLAAAER-----ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 112 LKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS-LVVEREKQKSEAKDRKVLE------ 164
L+EEL Q + E ++ R++ Q+ + L ER + R+ LE
Sbjct: 1741 LEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 165 ---ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ +++ A +F+ + L+ +I L ++ E K +KK K+ +
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 222 IKDTKECVQNKEEQN----------RLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
++D ++ + +EQ + ++ EEE+++++ L +L++ + +
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 272 RKEKYSTDAKIK 283
+E + +K++
Sbjct: 1918 GREVNALKSKLR 1929
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/292 (23%), Positives = 137/292 (46%), Gaps = 37/292 (12%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++LS+LK C A + W W+ P L V R++++ +AKD ++L+
Sbjct: 810 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKP------LLQVTRQEEELQAKDEELLK 863
Query: 165 ILQVK---DAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ + + + +++E E++ L +E N L ++ A E A + + L K ++ +
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 222 IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
+ D + V+ +EE+N++ L+ E KK+ DL L++ L+ EK + +AK
Sbjct: 924 LHDLESRVEEEEERNQI----LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 282 IKTFEDNLI-------EARKEVEVSQSKYNALSLQLS-------------NKQTELIQKD 321
IK E+ ++ + KE ++ + + S QL+ NKQ E++ D
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ-EVMISD 1038
Query: 322 MDITLVRKE--LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
++ L ++E QEL+ ++ T + I +LQ + + L +E+
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Score = 50.4 bits (119), Expect = 3e-06
Identities = 64/282 (22%), Positives = 126/282 (44%), Gaps = 20/282 (7%)
Query: 105 LEEELSSLKEEL--ALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKS-----EA 157
L+ +L+ +EEL AL + D E + L+V Q+ L + E +K+ E
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKN-NALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ R + E L+ ++++ + +QE+ KR+ V E L +E + E + +D
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAA-QQELR--TKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
Q E + + EQ + NLE+ + L T +L +++ L++ +A ++
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 278 TDAKIKTFEDNLIEA-RKEVEVSQSKYNALSLQLSNKQTEL-------IQKDMDITLVRK 329
DA+++ + E R VE+++ K + L +L N T L I+ D +
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAE-KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315
Query: 330 ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
+LQ+ Q L ++ + + I+QL+ Q+ +E+
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Score = 48.5 bits (114), Expect = 1e-05
Identities = 55/261 (21%), Positives = 116/261 (44%), Gaps = 37/261 (14%)
Query: 139 DLTQVVSLVVEREKQKSE-AKDRKVLE--------ILQVK-------DAKIQEFEQRESV 182
+L V +L+ E EK+ + AKD LE +LQ + ++I++ E+ ++
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 183 LKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD-----------KSQEIKDTKECVQN 231
L+++ + + + ++++ L+ + +D +KK D K + +KD E +
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA-EALSQ 1406
Query: 232 KEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTD---AKIKTFEDN 288
+ E+ L LE+ +L DL DL+ R+ ++L K++ D A+ K+
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 289 LIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQ-ELQNLYKQ-----NS 342
E R E + +L L+ E ++ + K+L+ ++++L +
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 343 THTAQQAELIQQLQVLNMDTQ 363
H ++++ + QV M TQ
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQ 1547
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/308 (20%), Positives = 142/308 (46%), Gaps = 28/308 (9%)
Query: 86 SRRLEGISVEEAMVTRTQ-LLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVV 144
S+RLE ++ + +T+ L++EL L +L ++ +L K+ + + L +
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDL---DHQRQVASNLEKKQKKFDQLLAEEK 1461
Query: 145 SLVV----EREKQKSEAKDR--KVLEILQVKDAKIQ---EFEQRESVLKQEINDLVKRKI 195
S+ ER++ ++EA+++ K L + + + ++ EFE++ L+ ++ DL+ K
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 196 AVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLE----EENKKLS 251
V + L K LE++ ++ ++++ ++ +Q E+ + N++ + + L
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 252 TRCTDLLND------LEKLRKQEAHL---RKEKYSTDAKIKTFEDNLIEARKEVEVSQSK 302
TR D N+ ++++R+ EA L RK++ A K E +L + ++E +
Sbjct: 1582 TR--DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 303 YNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDT 362
+ + QL Q ++ ++ R E+ K++ I QLQ +
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 363 QKVLRNQE 370
++ R+ E
Sbjct: 1700 ERARRHAE 1707
Score = 43.1 bits (100), Expect = 4e-04
Identities = 53/299 (17%), Positives = 129/299 (43%), Gaps = 42/299 (14%)
Query: 84 MGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQV 143
M S+ G +V E ++ + LE+++ ++ +L + + + RL+V +
Sbjct: 1517 MSSKDDVGKNVHELEKSK-RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 144 VSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESV-------LKQEINDLVKRKIA 196
++ +++E K R +++ ++ +A++++ ++ ++ ++ ++ DL + A
Sbjct: 1576 FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEA 1635
Query: 197 VDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTD 256
++ + K+ L+ + KD +E+++ + +++E + +E KKL + +
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKDYQRELEEARA---SRDE----IFAQSKESEKKLKSLEAE 1688
Query: 257 LLNDLEKLRKQE------------------------AHLRKEKYSTDAKIKTFEDNLIEA 292
+L E+L E + L EK +A+I E+ L E
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 293 RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL 351
+ +E+ ++ +LQ+ EL + + +K Q L +QN A+ EL
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELA---AERSAAQKSDNARQQLERQNKELKAKLQEL 1804
Score = 39.7 bits (91), Expect = 0.005
Identities = 52/244 (21%), Positives = 98/244 (40%), Gaps = 17/244 (6%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
S + A++ + LE ++ L+EEL Q++ E + +++ + L L ER
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN--AELAAERSA 1779
Query: 153 QKSEAKDRKVLEILQVKD--AKIQE--------FEQRESVLKQEINDLVKRKIAVDEENA 202
+ R+ LE Q K+ AK+QE F+ S L+ +I L ++ +E A
Sbjct: 1780 AQKSDNARQQLE-RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERA 1838
Query: 203 FLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLV---IKNLEEENKKLSTRCTDLLN 259
K EKK K+ +++D + +EQ +K L+ + ++ T
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
KL+++ + ++ T + N + + S S+ L L EL
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLK-NRLRRGGPISFSSSRSGRRQLHLEGASLELSD 1957
Query: 320 KDMD 323
D +
Sbjct: 1958 DDTE 1961
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 66.2 bits (160), Expect = 5e-11
Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 61/276 (22%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ ++ E L+ +A+ +E E++ L QE NDL ++ V E L
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDL---QLQVQAEQDNLND 902
Query: 207 EFSDLEKKFKDKSQ---EIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK 263
++ K+K Q ++K+ E ++++EE N L + +KL C++L D++
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA----ELTAKKRKLEDECSELKKDIDD 958
Query: 264 LRKQEAHLRKEKYSTDAKIKTFEDNLI---------------------EARKEVEVSQSK 302
L A + KEK++T+ K+K + + +A +++V + K
Sbjct: 959 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDK 1018
Query: 303 YNALS------------LQLSNKQTELIQKDM---------DITLVRKELQELQN----- 336
N+LS L+ S +Q + ++ D+ D+ L ++ + +L+N
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQL 1078
Query: 337 --LYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQE 370
K+ QQ I+ QVL + QK L+ +
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQ 1114
Score = 53.9 bits (128), Expect = 2e-07
Identities = 61/312 (19%), Positives = 131/312 (41%), Gaps = 36/312 (11%)
Query: 88 RLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQV-------TNPDL 140
R E + V++ M +E +LS A Q + + SL K Q+ N DL
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669
Query: 141 TQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEE 200
+ ++ +VER +A+ L+ A +++ E+ + +QE+ + +R + +
Sbjct: 1670 KENIA-IVERRNNLLQAE-------LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1721
Query: 201 NAFLRKEFSDLEKKFKDKSQEIKDT-KECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLN 259
N L + +E E+++ +EC +N EE+ KK T +
Sbjct: 1722 NTSLINQKKKMESDLTQLQSEVEEAVQEC------------RNAEEKAKKAITDAAMMAE 1769
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEA--------RKEVEVSQSKYNALSLQLS 311
+L+K + AHL + K + + IK + L EA +K+++ +++ L +L
Sbjct: 1770 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELE 1829
Query: 312 NKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
+Q + + + ++EL +++ + + +L+ +LQ+ ++ E+
Sbjct: 1830 AEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1889
Query: 372 VHTAESISYQKV 383
++KV
Sbjct: 1890 QANTNLSKFRKV 1901
Score = 50.1 bits (118), Expect = 3e-06
Identities = 51/240 (21%), Positives = 112/240 (46%), Gaps = 38/240 (15%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDL---VKRK----IAVDEE 200
+E K+K + + E ++ +AK E+ + L+ EI DL V+R A+D++
Sbjct: 1388 LEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447
Query: 201 NAFLRKEFSDLEKKFKDKSQEIKDTKE----------CVQNKEEQNRLVIKNLEEENKKL 250
K ++ ++K+++ E++ +++ ++N E++ ++ + ENK L
Sbjct: 1448 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1507
Query: 251 STRCTDL----------LNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
+DL +++LEK+RKQ L EK + ++ E +L ++ +Q
Sbjct: 1508 QEEISDLTEQLGEGGKNVHELEKVRKQ---LEVEKLELQSALEEAEASLEHEEGKILRAQ 1564
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
++N + ++ K L +KD ++ ++ Q + +S T+ AE + +VL +
Sbjct: 1565 LEFNQIKAEIERK---LAEKDEEMEQAKRNHQRV-----VDSLQTSLDAETRSRNEVLRV 1616
Score = 49.7 bits (117), Expect = 5e-06
Identities = 66/319 (20%), Positives = 140/319 (43%), Gaps = 33/319 (10%)
Query: 87 RRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSL 146
R+LEG + +T+ +++ E L+ E L + + + Q + + QV++L
Sbjct: 1055 RKLEG----DLKLTQESIMDLENDKLQLEEKLKKKEFDI------NQQNSKIEDEQVLAL 1104
Query: 147 VVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVD-------E 199
++++ ++++A+ ++ E L+ + + E+ S L +E+ ++ +R E
Sbjct: 1105 QLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1164
Query: 200 ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLV----IKNLEEENKKLSTRCT 255
N EF + + ++ + + + T ++ K + I NL+ +KL +
Sbjct: 1165 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1224
Query: 256 DLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQT 315
+ +L+ + + K K + + +T ED E R ++E +Q N + Q + QT
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284
Query: 316 E-------LIQKDMDIT-LVRKEL---QELQNLYKQNSTHTAQQAELIQQLQVLNMDTQK 364
E L +K+ I+ L R +L Q++++L +Q + L LQ D
Sbjct: 1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD- 1343
Query: 365 VLRNQEDVHTAESISYQKV 383
+LR Q + T Q+V
Sbjct: 1344 LLREQYEEETEAKAELQRV 1362
Score = 46.6 bits (109), Expect = 4e-05
Identities = 43/179 (24%), Positives = 81/179 (45%), Gaps = 13/179 (7%)
Query: 199 EENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLL 258
E +A R E +LE+ K +Q ++D +E V+ + +LE+ +L DL+
Sbjct: 1378 ETDAIQRTE--ELEEAKKKLAQRLQDAEEAVEAVNAK----CSSLEKTKHRLQNEIEDLM 1431
Query: 259 NDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALS---LQLSNKQT 315
D+E+ A L K++ + D + ++ E++ E+E SQ + +LS +L N
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1491
Query: 316 ELIQKDMDITLVRKELQE----LQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQE 370
E ++ K LQE L + + + ++ +QL+V ++ Q L E
Sbjct: 1492 ESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550
Score = 42.7 bits (99), Expect = 6e-04
Identities = 53/278 (19%), Positives = 120/278 (43%), Gaps = 52/278 (18%)
Query: 90 EGISVEEAMVTRTQLLEEELSSLKEELALCQ-----ADKEFVWSLWKRLQVTNPDLTQVV 144
E I++ E R LL+ EL L+ + + A++E + + +R+Q+ + +Q
Sbjct: 1671 ENIAIVER---RNNLLQAELEELRAVVEQTERSRKLAEQELIETS-ERVQLLH---SQNT 1723
Query: 145 SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFL 204
SL+ +++K +S+ + ++ + +QE E K+ I D + +E
Sbjct: 1724 SLINQKKKMESD-----LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE---- 1774
Query: 205 RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK- 263
+ + LE+ K+ Q IKD + + +E ++ +K +++ +KL R +L +LE
Sbjct: 1775 QDTSAHLERMKKNMEQTIKDLQHRL---DEAEQIALKGGKKQLQKLEARVRELEGELEAE 1831
Query: 264 ----------LRKQEAHLRKEKYSTDA-----------------KIKTFEDNLIEARKEV 296
+RK E +++ Y T+ K+K ++ EA ++
Sbjct: 1832 QKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1891
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+ SK+ + +L + + + +R + +++
Sbjct: 1892 NTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
Score = 42.0 bits (97), Expect = 0.001
Identities = 70/364 (19%), Positives = 150/364 (41%), Gaps = 79/364 (21%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQAD-KEFVWSLWKRLQVTNPDLTQVVSLV 147
L+ E+ M T ++EE +KE L +A KE + LQ N DL V
Sbjct: 842 LKSAETEKEMAT----MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKN-DLQLQVQAE 896
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
+ E D+ + +Q+ +AK++E +R ++ +L +K +++E + L+K+
Sbjct: 897 QDNLNDAEERCDQLIKNKIQL-EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD 955
Query: 208 FSDLE--------------KKFKDKSQEIKDTKECVQNKEEQNRLV-------------- 239
DLE K K+ ++E+ E + ++ + +
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 240 ---IKNLEEENKKLSTRCTDLLNDLEKLRK-------------------QEA--HLRKEK 275
+ +L + KL + DL LE+ +K QE+ L +K
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 276 YSTDAKIKTFEDNL--------------IEARKEVEVSQSKYNALSLQLSNKQTELIQKD 321
+ K+K E ++ ++ +K+++ +Q++ L +L ++T + +
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVE 1135
Query: 322 MDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV---HTAESI 378
+ + +EL+E+ ++ T+ Q E+ ++ + + QK+ R+ E+ H A +
Sbjct: 1136 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA---EFQKMRRDLEEATLQHEATAA 1192
Query: 379 SYQK 382
+ +K
Sbjct: 1193 ALRK 1196
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 65.5 bits (158), Expect = 8e-11
Identities = 51/251 (20%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
Query: 106 EEELSSLKEELALCQADKE----FVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
+EELS +++E+ + D E + L L T +L + + V E EK + + + +
Sbjct: 996 KEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQ-HSTETE 1054
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ E LQ ++ E + LK + L + + + + L ++++ + KD + E
Sbjct: 1055 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI----KDLTAE 1110
Query: 222 IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
+++ K +++K+++ + + L+E N +L R + + +R+ + ++ +
Sbjct: 1111 LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGT 1170
Query: 282 IKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQN 341
++ E L E K++E K QL K+ ++Q + +I+ ++KE++ Q K+
Sbjct: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEM 1230
Query: 342 STHTAQQAELI 352
+ +Q + I
Sbjct: 1231 ESVMKEQEQYI 1241
Score = 55.5 bits (132), Expect = 8e-08
Identities = 53/233 (22%), Positives = 102/233 (43%), Gaps = 38/233 (16%)
Query: 104 LLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR--- 160
+LEE++ +L+ E++ K L+ L Q +V+E+E+ E+K+
Sbjct: 288 ILEEQIINLEAEVSAQD----------KVLREAENKLEQSQKMVIEKEQSLQESKEECIK 337
Query: 161 -KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
KV + Q K K E ++ E++ E +L K F+
Sbjct: 338 LKVDLLEQTKQGKRAERQRNEALYNAE-----------------------ELSKAFQQYK 374
Query: 220 QEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTD 279
+++ + E VQ +EE + N E+ENK+L RC ++LE L+++ L++E +
Sbjct: 375 KKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGK 434
Query: 280 AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQ 332
K++ E ++ S+ L +L NK E+++ + +EL+
Sbjct: 435 EKLRIMAVKNSEVMAQLTESRQSILKLESELENKD-EILRDKFSLMNENRELK 486
Score = 51.2 bits (121), Expect = 2e-06
Identities = 56/261 (21%), Positives = 126/261 (48%), Gaps = 23/261 (8%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPD-LTQVVSLVVEREKQKSEAKD 159
+ ++LE EL + EL + + + ++ Q++ + T + L E + K E +D
Sbjct: 1061 KREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIED 1120
Query: 160 RKVLEILQVKDA-KIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEK---KF 215
+K E+L++ A K + +E ++ + D+ R+ + E ++ E LEK +
Sbjct: 1121 KKQ-ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSELEL 1178
Query: 216 KDKSQEIKDTKECVQNKEEQNR----LVIKNLEE--ENKKLSTRCTDLLNDLEKLRKQEA 269
K+ +++I+ + +QN +EQ R ++++N +E + KK R + ++E + K++
Sbjct: 1179 KECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQ- 1237
Query: 270 HLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK 329
E+Y I T I+ +E+ +++ + +L+ + + +Q +I +
Sbjct: 1238 ----EQY-----IATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSS 1288
Query: 330 ELQELQNLYKQNSTHTAQQAE 350
EL++++ L K+ H AE
Sbjct: 1289 ELEDMKQLSKEKDAHGNHLAE 1309
Score = 44.3 bits (103), Expect = 2e-04
Identities = 60/314 (19%), Positives = 134/314 (42%), Gaps = 30/314 (9%)
Query: 79 LLSAPMGSRRLEGISVEEAM----------VTRTQLLEEELSSLKEELAL----CQADKE 124
LL+ G + E + +EA+ + + L+ L KEEL L + +KE
Sbjct: 811 LLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKE 870
Query: 125 FVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLK 184
K+L+ + ++ + + + E ++ V ILQ + Q+ Q+E++
Sbjct: 871 ---KFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNV--ILQHTLQQQQQMLQQETIRN 925
Query: 185 QEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLE 244
E+ D + ++++ + L +E + +K +++++ E ++ + R + L
Sbjct: 926 GELEDTQTK---LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELT 982
Query: 245 EENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYN 304
+++ +L K+ K+ HL+++ + + + L + + E+E +
Sbjct: 983 GTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVK 1042
Query: 305 ALSLQLSNKQTELIQKDMDITLVRKEL--QELQNLYKQNSTHTAQQAELIQQLQVLNMDT 362
L + +TEL + L ++E+ ELQN + + + Q EL LQ +
Sbjct: 1043 ELEKLQHSTETELTE-----ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSL 1097
Query: 363 QKVLRNQEDVHTAE 376
++ +D+ TAE
Sbjct: 1098 EEKYTTIKDL-TAE 1110
Score = 43.1 bits (100), Expect = 4e-04
Identities = 47/225 (20%), Positives = 100/225 (44%), Gaps = 21/225 (9%)
Query: 148 VEREKQKSEAKDRKVLEI-LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
+ E+ K K + LE L+ KD Q+F+++E + D++ ++ ++ + L +
Sbjct: 758 IHLEQHKEMEKQIERLEAQLEKKD---QQFKEQEKTMSMLQQDIICKQHHLESLDRLLTE 814
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
+++K+ K + +K + V + + R + LE ++L L + EK K
Sbjct: 815 SKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
Q +E Y ++K +L E S+ N + +Q +++Q++ T+
Sbjct: 875 QLKKKSEEVYCLQKELKIKNHSLQET--------SEQNVILQHTLQQQQQMLQQE---TI 923
Query: 327 VRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
EL++ Q ++ Q ++L Q+LQ + + LR E+
Sbjct: 924 RNGELEDTQTKLEK------QVSKLEQELQKQRESSAEKLRKMEE 962
Score = 39.3 bits (90), Expect = 0.006
Identities = 40/219 (18%), Positives = 94/219 (42%), Gaps = 19/219 (8%)
Query: 176 FEQRESVLKQEINDLVKRKIA----VDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQN 231
FE +S K + + +++ A ++E+ L E S +K ++ +++ +++ V
Sbjct: 264 FELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIE 323
Query: 232 KEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIE 291
KE+ +L+E ++ DLL ++ ++ E + Y+ + K F+ +
Sbjct: 324 KEQ-------SLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKK 376
Query: 292 ARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL 351
+++E Q++ L L+N + E + L + EL+ L+ +Q E
Sbjct: 377 VAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEK 436
Query: 352 IQQLQVLNMDT--------QKVLRNQEDVHTAESISYQK 382
++ + V N + Q +L+ + ++ + I K
Sbjct: 437 LRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDK 475
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 64.3 bits (155), Expect = 2e-10
Identities = 67/297 (22%), Positives = 136/297 (45%), Gaps = 25/297 (8%)
Query: 97 AMVTRTQLLEEELSSLKEELALCQAD----KEFVWSLWKRLQVTNPDLTQVVSLVVE--- 149
AM + Q E ++SL+EELA Q K+ + K V + T++ + E
Sbjct: 1854 AMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWAN 1913
Query: 150 --REKQKSEAKDRKVLEILQ--VKDAKIQ------EFEQRESVLKQEINDLVKRKIAVDE 199
+ QK E ++ L++LQ +++ K++ F++ + + E + L K+ + E
Sbjct: 1914 RFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKE 1973
Query: 200 ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRL---VIKNLEEENKKLSTRCTD 256
+ L KE +D + K ++ +E V+ +E+ R + K L + ++LS R
Sbjct: 1974 QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQ 2033
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVS-QSKYNALSLQLSNKQT 315
L+ +L L+KE S A + + RK+ E S AL +Q S +
Sbjct: 2034 LVEKSGELLA----LQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEK 2089
Query: 316 ELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
L+++ + + ++KE+ ++ + + N + + + Q+Q + +K + NQ+D+
Sbjct: 2090 NLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDL 2146
Score = 56.6 bits (135), Expect = 4e-08
Identities = 66/305 (21%), Positives = 131/305 (42%), Gaps = 34/305 (11%)
Query: 103 QLLEEELSSLK--EELALCQADKEFVWSLWKRLQVTN-PDLTQVVSLVVEREKQKSEAKD 159
QL EL LK + + + +K V L ++L++ N ++Q +E +KQ E +D
Sbjct: 1706 QLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLE-RD 1764
Query: 160 RKVLEILQVKDAKIQEFEQRESVLKQEINDL----------VKRKIAVDEENAFLRKEFS 209
++ +E + + +Q + S K+++ + KR +A EEN+ + E S
Sbjct: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENS--KMEQS 1822
Query: 210 DLEK------KFKDKSQEIKDTK-------ECVQNKEEQNRLVIKNLEEENKKLSTRCTD 256
+LEK K + + ++ K +Q + ++ R + +L+EE +
Sbjct: 1823 NLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNL 1882
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTE 316
DL K + L E+ I + + + +KE E Q + L ++ + +
Sbjct: 1883 AKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLK 1942
Query: 317 LIQKDMDITLVRKELQELQNLYKQNSTHTAQQ-----AELIQQLQVLNMDTQKVLRNQED 371
L+Q++M ++KE + ++ + + +Q EL Q L+ KVL +E
Sbjct: 1943 LVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEER 2002
Query: 372 VHTAE 376
V T +
Sbjct: 2003 VRTLQ 2007
Score = 50.4 bits (119), Expect = 3e-06
Identities = 63/294 (21%), Positives = 129/294 (43%), Gaps = 32/294 (10%)
Query: 107 EELSSLKEELAL---CQADKEFVWS-LWKRLQVTNPDLTQVVSLVVEREKQKSE-AKDRK 161
EE L+E + L +A K+ ++ L RLQ+ N + + L ++ EKQK E A +K
Sbjct: 472 EEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQK 531
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
++ LQ+ + + + S +K + + ++ ++++ L ++ + +++E
Sbjct: 532 EIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
Query: 222 IKDTKE------CVQNKEEQNRL--VIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRK 273
IKD +E N+ + L VI L+E + + T N+ KLR ++ L +
Sbjct: 592 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQ 651
Query: 274 EKYSTDAKIKTFE----------------DNLIEARKEVEVS-QSKYNALSLQLSNKQTE 316
+ + E ++ ++ + EV S Q LS + +
Sbjct: 652 RLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEAR 711
Query: 317 LIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQE 370
L +D + +++EL+++ L + +A QAEL ++ Q L K ++E
Sbjct: 712 LNLRDAEANQLKEELEKVTRLTQLE--QSALQAELEKERQALKNALGKAQFSEE 763
Score = 50.4 bits (119), Expect = 3e-06
Identities = 77/392 (19%), Positives = 153/392 (39%), Gaps = 38/392 (9%)
Query: 6 PPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGEEGSGG 65
PP P+ S P +G V E H + +E S + + + + ++ W+ +
Sbjct: 1296 PPPPNFSIPFIPMGVLHCNV---PEHHNLENEVSRLEDIMQHLKSKKREERWMR---ASK 1349
Query: 66 RRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVT------RTQLLEEELSSLKEELALC 119
R+ H + + LE VEE T + ++ + SL EL +
Sbjct: 1350 RQSEKEMEELHHNIDDLLQEKKSLE-CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE 1408
Query: 120 QADKEF------VWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAK- 172
++ K + + K L +L + L+ E E + S K++ + + DAK
Sbjct: 1409 KSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR 1468
Query: 173 -IQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQN 231
+ + E L++ + + D++ L+ + DLE+ + + +K+ + V
Sbjct: 1469 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAA 1528
Query: 232 KEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIE 291
K+ + L ++ +KL+ L D+E + E H + ++ ++ L +
Sbjct: 1529 KDSD----FQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1584
Query: 292 ARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNST----HTAQ 347
+ +V Q + L QL +K+ EL + + +LQE L + T H +
Sbjct: 1585 LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Query: 348 QAELIQQL---------QVLNMDTQKVLRNQE 370
L+++L Q+ TQ L QE
Sbjct: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQE 1676
Score = 48.9 bits (115), Expect = 8e-06
Identities = 66/314 (21%), Positives = 137/314 (43%), Gaps = 42/314 (13%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLT---------QVVSLVVERE 151
+T+ E+ + K L ++D E L +R Q T +L Q + +E+
Sbjct: 1455 KTKNAVEKFTDAKRSLLQTESDAE---ELERRAQETAVNLVKADQQLRSLQADAKDLEQH 1511
Query: 152 KQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVK----------RKIAVDEEN 201
K K E +++ +I+ KD+ Q +++ L +E+ L K + V +E+
Sbjct: 1512 KIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKES 1571
Query: 202 AFL----RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI-------KNLEEENKKL 250
L R E L+ + + QE+ + +K+E+ L+ +L+E +
Sbjct: 1572 EVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLG 1631
Query: 251 STRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL 310
T T+ N + +++ L +K + +I + L ++E+E + + Q+
Sbjct: 1632 ETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQM 1691
Query: 311 SNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQE 370
S +TEL K++ + +++ E ELQ L Q+ Q+ +++ QV ++ + L N +
Sbjct: 1692 SKHKTEL--KNI-LDMLQLENHELQGLKLQHD----QRVSELEKTQVAVLEEKLELENLQ 1744
Query: 371 DVHTAE--SISYQK 382
+ + I +QK
Sbjct: 1745 QISQQQKGEIEWQK 1758
Score = 41.6 bits (96), Expect = 0.001
Identities = 48/246 (19%), Positives = 119/246 (48%), Gaps = 10/246 (4%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVT-NPDLTQVVSLVVEREKQ 153
+EA V R + L+EE++ +E+LA Q +EF + + L+ N D Q + + + E +
Sbjct: 859 DEAQV-RERKLQEEMALQQEKLATGQ--EEFRQACERALEARMNFDKRQHEARIQQMENE 915
Query: 154 KSEAKD--RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDL 211
++ + + EI + D ++QE ++ + + ++ +L K+K E+A +++ L
Sbjct: 916 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKK---KLEDAKSQEQVFGL 972
Query: 212 EKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
+K+ K + + + + + + +K+L K++ + L + E+ ++ A
Sbjct: 973 DKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQA 1032
Query: 272 RKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
++ +A+I+ + NL+ + E + + + +++ E+ + + + R E+
Sbjct: 1033 ARDLTRAEAEIELLQ-NLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEI 1091
Query: 332 QELQNL 337
LQN+
Sbjct: 1092 ARLQNV 1097
Score = 36.6 bits (83), Expect = 0.040
Identities = 49/225 (21%), Positives = 104/225 (46%), Gaps = 43/225 (19%)
Query: 147 VVEREKQKSE--AKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEEN--- 201
+ + +KQ SE A+ + + QV++ K+QE E L+QE K+A +E
Sbjct: 840 LADLQKQFSEILARSKWERDEAQVRERKLQE----EMALQQE-------KLATGQEEFRQ 888
Query: 202 -------AFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254
A + + E + + EI +E +++ EE L L+E +++ R
Sbjct: 889 ACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEE-KERI 947
Query: 255 TDLLNDLEKLRK-QEAHLRKEKYSTDAKIKTFEDNLIEARK----EVEVSQSKYNALS-- 307
L +LEK +K ++A +++ + D ++K + + + K E+ +++ + +L
Sbjct: 948 LAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGT 1007
Query: 308 -LQLSNKQTELIQKD-----------MDITLVRKELQELQNLYKQ 340
++++ ++ E +Q+ D+T E++ LQNL +Q
Sbjct: 1008 VMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQ 1052
Score = 35.0 bits (79), Expect = 0.12
Identities = 54/291 (18%), Positives = 124/291 (42%), Gaps = 62/291 (21%)
Query: 141 TQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVK---RKIAV 197
T+ + + ++K K+ +L+ ++ K + + +LKQ+ +L + ++ +
Sbjct: 294 TRFLEEIKNQDKLNKSLKEEAMLQKQSCEELK-SDLNTKNELLKQKTIELTRACQKQYEL 352
Query: 198 DEENAFLR------------KEFSDLEKK-----FKDKSQE----------IKDTKECVQ 230
++E AF + E+++++K + KS+ I D+ + VQ
Sbjct: 353 EQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQ 412
Query: 231 NKEEQNRLVIKN--------------LEEENKKLS---TRCTDLLNDLEKLRKQEAHLRK 273
K+ + ++N LE++ KK+S TR ++L +++EK +Q +
Sbjct: 413 IKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATE 472
Query: 274 EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA------------LSLQLSNKQTELIQKD 321
E + I+ + EA K++ Q L LQ+ ++ E+ K
Sbjct: 473 EFKQLEEAIQL--KKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQ 530
Query: 322 MDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
+I ++ + L + ++S AQ++ QQL ++N Q++ +++
Sbjct: 531 KEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEI 581
Score = 35.0 bits (79), Expect = 0.12
Identities = 40/224 (17%), Positives = 94/224 (41%), Gaps = 18/224 (8%)
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDT 225
L+ + +++++ Q K+E + K ++E L DL ++ K E+++
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 226 KECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAH-------LRKEKYST 278
VQ +++Q + N+E +L ++EK K + K
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTEL---------EIEKSLKHHEDIVDEIECIEKTLLKR 1431
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ-NL 337
++++ + L EA E+ ++ K + ++ + L+Q + D + + QE NL
Sbjct: 1432 RSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
Query: 338 YKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQ 381
K + + QA+ + L+ + +++L+ + A+ +Q
Sbjct: 1492 VKADQQLRSLQAD-AKDLEQHKIKQEEILKEINKIVAAKDSDFQ 1534
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 63.9 bits (154), Expect = 2e-10
Identities = 51/283 (18%), Positives = 132/283 (46%), Gaps = 20/283 (7%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQK 154
EE + + + + E+ ++E+ + +E +W ++++ E +
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ------------EEMMWE 360
Query: 155 SEAKDRKVLEILQVKDAKIQEFEQR----ESVLKQEINDLVKRKIAVDEENAFLRKEFSD 210
E K R++ E++ K+ KI+E E++ E + +QE + KI E+ +
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 420
Query: 211 LEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAH 270
E+K +++ ++I++ ++ + +EE+ K EEE ++ ++ EK+R+QE
Sbjct: 421 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE---EMWRQEEKIREQEEI 477
Query: 271 LR-KEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK 329
R KEK KI+ E+ + +++ + K ++ ++ ++ +++ I +
Sbjct: 478 WRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE 537
Query: 330 ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
+++E + + ++ +Q E +Q+ + + +K+ +E +
Sbjct: 538 KIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKI 580
Score = 53.5 bits (127), Expect = 3e-07
Identities = 49/252 (19%), Positives = 118/252 (46%), Gaps = 20/252 (7%)
Query: 131 KRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKI----QEFEQRESVLKQE 186
+ L+ N L + + LV E +KSE + +++ AK+ Q+ + L +E
Sbjct: 217 EELKEKNAKLQEKLQLV---ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 187 INDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEE 246
+ + + A EEN + E+K + ++I++ +E +Q +EE+ R + + E+
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 247 NKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNAL 306
+K+ + + EK+R+QE + + + K++ E+ + E +++ + K +
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMM----WEKEEKMRRLEEMMWEKEEKIRELEEKMH-- 387
Query: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
+ E I++ + ++++E + +Q + Q+ ++ +Q + + +K+
Sbjct: 388 -------EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Query: 367 RNQEDVHTAESI 378
R +E +H E I
Sbjct: 441 RQEEKIHEQEKI 452
Score = 50.4 bits (119), Expect = 3e-06
Identities = 46/215 (21%), Positives = 107/215 (49%), Gaps = 21/215 (9%)
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFE----QRESVLKQE--INDLVKRKIAVDEENA 202
+ E + E K R+ EI + K+ K+ E E Q E V +QE ++D + KI EE
Sbjct: 461 QEEMWRQEEKIREQEEIWRQKE-KMHEQEKIRKQEEKVWRQEEKMHDQ-EEKIREQEEKM 518
Query: 203 FLRKE-FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDL 261
+ ++E + E+K +++ ++I++ +E +Q +EE+ + ++E+ K +
Sbjct: 519 WRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEK--------MRRQE 570
Query: 262 EKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKD 321
EK+R+QE +R++K KI+ E+ + E +++ + ++ ++ ++ +++
Sbjct: 571 EKIREQEEKIREQK----EKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 626
Query: 322 MDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQ 356
+ ++++ + + QQ E +Q+ Q
Sbjct: 627 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 48.5 bits (114), Expect = 1e-05
Identities = 29/156 (18%), Positives = 89/156 (57%), Gaps = 8/156 (5%)
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE- 207
E + + E K R+ E ++ ++ KI+E +E +++++ + +++ + E+ R+E
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIRE---QEEMMQEQEEKMGEQEEKMQEQEKMRRQEE 571
Query: 208 -FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
+ E+K +++ ++I++ +E + +EE+ R + ++E+ +K+ + + EK+++
Sbjct: 572 KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 631
Query: 267 QEAHLRKEK---YSTDAKIKTFEDNLIEARKEVEVS 299
QE +R+++ + + +++ E+ + E ++ +E +
Sbjct: 632 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 40.8 bits (94), Expect = 0.002
Identities = 35/142 (24%), Positives = 73/142 (51%), Gaps = 10/142 (7%)
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE- 207
E + ++ E K R+ E++Q ++ K+ E Q E + +QE + KI EE +KE
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMGE--QEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK---- 263
+ E+K ++ ++I++ +E +Q +EE+ + + E+ +K+ + + EK
Sbjct: 587 IREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 646
Query: 264 ---LRKQEAHLRKEKYSTDAKI 282
LR+QE +++ + +A I
Sbjct: 647 EVRLRQQEEKMQEHQEHLEAAI 668
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 63.5 bits (153), Expect = 3e-10
Identities = 69/325 (21%), Positives = 144/325 (44%), Gaps = 42/325 (12%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVV 148
L+ E+ M T ++EE +K+ELA +A ++ + L DL V
Sbjct: 846 LKSAETEKEMAT----MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA 901
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKE 207
E E D+ + +Q+ +AKI+E +R ++EIN +L +K +++E + L+K+
Sbjct: 902 EGLADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKD 959
Query: 208 FSDLE--------------KKFKDKSQEIKDTKECVQNK-------EEQNRLVIKNLEEE 246
DLE K K+ ++E+ E + +E ++ + +L+ E
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 247 NKKLST----------RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEV 296
K++T + DL LE+ +K L + K + +K ++++++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELI 352
+ K ++SN Q+++ + ++K+++ELQ L ++ A +A+
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 353 QQLQVLNMDTQKVLRNQEDVHTAES 377
+Q L+ + +++ E+ A S
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATS 1164
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/254 (22%), Positives = 110/254 (43%), Gaps = 32/254 (12%)
Query: 110 SSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQ-- 167
S +++E AL ++ + L R++ ++ + + EKQ+S+ R++ EI +
Sbjct: 1098 SKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERL 1156
Query: 168 -----VKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI 222
A+I+ ++RE+ ++ DL + + + A LRK+ +D + ++ +
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 223 KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKI 282
+ K+ LE+E ++ DL +++E + K + +L K
Sbjct: 1217 QRVKQ--------------KLEKEKSEMKMEIDDLASNVETVSKAKGNLEK-------MC 1255
Query: 283 KTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNS 342
+T ED L E + + E Q N L+ Q QTE + L KE + L +
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE--SGEFSRQLDEKEAL-VSQLSRGKQ 1312
Query: 343 THTAQQAELIQQLQ 356
T Q EL +QL+
Sbjct: 1313 AFTQQIEELKRQLE 1326
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/257 (22%), Positives = 113/257 (43%), Gaps = 40/257 (15%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R Q EE+ S + + AL +A+ E + W+ T+ ++R ++ EAK +
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEV--AQWRTKYETD---------AIQRTEELEEAK-K 1397
Query: 161 KVLEILQVKD-------AKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEK 213
K+ + LQ + AK E+ + L+ E+ DL+ + A L K+ + +K
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 214 KFKDKSQEIKDT--------KEC---------VQNKEEQNRLVIKNLEEENKKLSTRCTD 256
+ Q+ ++T KE ++N E++ ++ L+ ENK L +D
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTE 316
L + + K+ L K K + + + L EA +E + K + L+L+ ++E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 317 ----LIQKDMDITLVRK 329
+ +KD +I +++
Sbjct: 1578 VDRKIAEKDEEIDQLKR 1594
Score = 47.4 bits (111), Expect = 2e-05
Identities = 73/308 (23%), Positives = 123/308 (39%), Gaps = 46/308 (14%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS---LVVERE 151
E + RT+ LEE L + L + E V + L+ T L V L VER
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441
Query: 152 KQKSEAKDRK-------VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDE----- 199
A D+K + E Q + E E + + +L K K A +E
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 200 -----ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254
EN L++E SDL ++ + + I + ++ + E++ + LEE L
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE--- 1558
Query: 255 TDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQ 314
++ K+ + + L + K D KI A K+ E+ Q K N + + S +
Sbjct: 1559 ----HEEGKILRIQLELNQVKSEVDRKI---------AEKDEEIDQLKRNHIRIVESMQS 1605
Query: 315 T---ELIQKDMDITLVRK---ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQ----K 364
T E+ ++ I L +K +L E++ + A+ + Q + DTQ
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 365 VLRNQEDV 372
LR+QED+
Sbjct: 1666 ALRSQEDL 1673
Score = 44.7 bits (104), Expect = 1e-04
Identities = 46/256 (17%), Positives = 101/256 (39%), Gaps = 32/256 (12%)
Query: 160 RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
R IL+ + + + + LK+++ + +R + E LR E+ K
Sbjct: 1650 RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE 1709
Query: 220 QEIKDTKECVQNKEEQNRLVI------------------------KNLEEENKKLSTRCT 255
QE+ D E VQ QN +I +N EE+ KK T
Sbjct: 1710 QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA 1769
Query: 256 DLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEA--------RKEVEVSQSKYNALS 307
+ +L+K + AHL + K + + +K + L EA +K+++ +++ L
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 308 LQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLR 367
++ ++Q + + + ++EL +++ + + +L+ +LQ ++
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 368 NQEDVHTAESISYQKV 383
E+ ++K+
Sbjct: 1890 EAEEQSNTNLAKFRKL 1905
Score = 42.4 bits (98), Expect = 7e-04
Identities = 44/200 (22%), Positives = 81/200 (40%), Gaps = 29/200 (14%)
Query: 206 KEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLR 265
+E + +KK + Q ++ E V K +LE+ ++L DL+ D+E+
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAK-------CASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 266 KQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL--------------- 310
A L K++ + D + ++ E E+E SQ + +L +L
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 311 ------SNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQ-QAELIQQLQVLNMDTQ 363
N Q E+ I K + EL+ + KQ + QA L + L +
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 364 KVLRNQEDVHTAESISYQKV 383
K+LR Q +++ +S +K+
Sbjct: 1563 KILRIQLELNQVKSEVDRKI 1582
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 63.5 bits (153), Expect = 3e-10
Identities = 69/325 (21%), Positives = 144/325 (44%), Gaps = 42/325 (12%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVV 148
L+ E+ M T ++EE +K+ELA +A ++ + L DL V
Sbjct: 846 LKSAETEKEMAT----MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA 901
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKE 207
E E D+ + +Q+ +AKI+E +R ++EIN +L +K +++E + L+K+
Sbjct: 902 EGLADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKD 959
Query: 208 FSDLE--------------KKFKDKSQEIKDTKECVQNK-------EEQNRLVIKNLEEE 246
DLE K K+ ++E+ E + +E ++ + +L+ E
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 247 NKKLST----------RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEV 296
K++T + DL LE+ +K L + K + +K ++++++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELI 352
+ K ++SN Q+++ + ++K+++ELQ L ++ A +A+
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 353 QQLQVLNMDTQKVLRNQEDVHTAES 377
+Q L+ + +++ E+ A S
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATS 1164
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/254 (22%), Positives = 110/254 (43%), Gaps = 32/254 (12%)
Query: 110 SSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQ-- 167
S +++E AL ++ + L R++ ++ + + EKQ+S+ R++ EI +
Sbjct: 1098 SKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERL 1156
Query: 168 -----VKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI 222
A+I+ ++RE+ ++ DL + + + A LRK+ +D + ++ +
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 223 KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKI 282
+ K+ LE+E ++ DL +++E + K + +L K
Sbjct: 1217 QRVKQ--------------KLEKEKSEMKMEIDDLASNVETVSKAKGNLEK-------MC 1255
Query: 283 KTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNS 342
+T ED L E + + E Q N L+ Q QTE + L KE + L +
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE--SGEFSRQLDEKEAL-VSQLSRGKQ 1312
Query: 343 THTAQQAELIQQLQ 356
T Q EL +QL+
Sbjct: 1313 AFTQQIEELKRQLE 1326
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/257 (22%), Positives = 113/257 (43%), Gaps = 40/257 (15%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R Q EE+ S + + AL +A+ E + W+ T+ ++R ++ EAK +
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEV--AQWRTKYETD---------AIQRTEELEEAK-K 1397
Query: 161 KVLEILQVKD-------AKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEK 213
K+ + LQ + AK E+ + L+ E+ DL+ + A L K+ + +K
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 214 KFKDKSQEIKDT--------KEC---------VQNKEEQNRLVIKNLEEENKKLSTRCTD 256
+ Q+ ++T KE ++N E++ ++ L+ ENK L +D
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTE 316
L + + K+ L K K + + + L EA +E + K + L+L+ ++E
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 317 ----LIQKDMDITLVRK 329
+ +KD +I +++
Sbjct: 1578 VDRKIAEKDEEIDQLKR 1594
Score = 47.4 bits (111), Expect = 2e-05
Identities = 73/308 (23%), Positives = 123/308 (39%), Gaps = 46/308 (14%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS---LVVERE 151
E + RT+ LEE L + L + E V + L+ T L V L VER
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441
Query: 152 KQKSEAKDRK-------VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDE----- 199
A D+K + E Q + E E + + +L K K A +E
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 200 -----ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254
EN L++E SDL ++ + + I + ++ + E++ + LEE L
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE--- 1558
Query: 255 TDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQ 314
++ K+ + + L + K D KI A K+ E+ Q K N + + S +
Sbjct: 1559 ----HEEGKILRIQLELNQVKSEVDRKI---------AEKDEEIDQLKRNHIRIVESMQS 1605
Query: 315 T---ELIQKDMDITLVRK---ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQ----K 364
T E+ ++ I L +K +L E++ + A+ + Q + DTQ
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 365 VLRNQEDV 372
LR+QED+
Sbjct: 1666 ALRSQEDL 1673
Score = 44.7 bits (104), Expect = 1e-04
Identities = 46/256 (17%), Positives = 101/256 (39%), Gaps = 32/256 (12%)
Query: 160 RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
R IL+ + + + + LK+++ + +R + E LR E+ K
Sbjct: 1650 RNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAE 1709
Query: 220 QEIKDTKECVQNKEEQNRLVI------------------------KNLEEENKKLSTRCT 255
QE+ D E VQ QN +I +N EE+ KK T
Sbjct: 1710 QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA 1769
Query: 256 DLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEA--------RKEVEVSQSKYNALS 307
+ +L+K + AHL + K + + +K + L EA +K+++ +++ L
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1829
Query: 308 LQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLR 367
++ ++Q + + + ++EL +++ + + +L+ +LQ ++
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 368 NQEDVHTAESISYQKV 383
E+ ++K+
Sbjct: 1890 EAEEQSNTNLAKFRKL 1905
Score = 42.4 bits (98), Expect = 7e-04
Identities = 44/200 (22%), Positives = 81/200 (40%), Gaps = 29/200 (14%)
Query: 206 KEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLR 265
+E + +KK + Q ++ E V K +LE+ ++L DL+ D+E+
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAK-------CASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 266 KQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL--------------- 310
A L K++ + D + ++ E E+E SQ + +L +L
Sbjct: 1443 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLE 1502
Query: 311 ------SNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQ-QAELIQQLQVLNMDTQ 363
N Q E+ I K + EL+ + KQ + QA L + L +
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEG 1562
Query: 364 KVLRNQEDVHTAESISYQKV 383
K+LR Q +++ +S +K+
Sbjct: 1563 KILRIQLELNQVKSEVDRKI 1582
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 62.0 bits (149), Expect = 9e-10
Identities = 78/306 (25%), Positives = 141/306 (46%), Gaps = 48/306 (15%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
S+EEA +++ ++E L EE L Q + + KR + + DL Q + E K
Sbjct: 724 SIEEA---KSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK 780
Query: 153 QK---SEAKDRKVLEI-------------LQVKDAKIQEFEQRESVLKQEINDLVKRKIA 196
QK +E L+I L+++ ++ + E LKQE N L++ K+
Sbjct: 781 QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN 840
Query: 197 VDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTD 256
++++NA LRKE D + + K E++D E Q + ++ L+EE C +
Sbjct: 841 LEKQNAELRKERQDADGQMK----ELQDQLEAEQYFSTLYKTQVRELKEE-------CEE 889
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTE 316
++L++++ L+ E+ S A++ E L +A E Q + Q S+ + E
Sbjct: 890 KTKLGKELQQKKQELQDERDSLAAQL---EITLTKADSE----QLARSIAEEQYSDLEKE 942
Query: 317 LIQKDMDITLV----RKELQE----LQNLYKQNSTHTAQQAELIQQLQVLN---MDTQKV 365
I K+++I + ++EL E + +L + N T T+ A L + + LN D Q+
Sbjct: 943 KIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQ 1002
Query: 366 LRNQED 371
L +D
Sbjct: 1003 LSRLKD 1008
Score = 47.0 bits (110), Expect = 3e-05
Identities = 58/251 (23%), Positives = 115/251 (45%), Gaps = 38/251 (15%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVER---EKQKSEAKDRK 161
L +EL K+EL Q +++ SL +L++T LT+ S + R E+Q S+ + K
Sbjct: 893 LGKELQQKKQEL---QDERD---SLAAQLEIT---LTKADSEQLARSIAEEQYSDLEKEK 943
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+++ L++K+ + KQE+ + +++E N L + ++L + ++ + +
Sbjct: 944 IMKELEIKEMMARH--------KQELTEKDATIASLEETNRTLTSDVANLANEKEELNNK 995
Query: 222 IKDTKECVQN-KEEQNRLVIKNLEEENKKLSTRC--TDLLNDLEKL-------------- 264
+KD +E + K+E+ + E + L+ R T +N L ++
Sbjct: 996 LKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTD 1055
Query: 265 -RKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD 323
R++E RK ++ + +I+ +KE+ Q++ S Q L KD D
Sbjct: 1056 VRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSD 1115
Query: 324 ITLVRKELQEL 334
I +R +LQ L
Sbjct: 1116 IEQLRSQLQAL 1126
Score = 45.1 bits (105), Expect = 1e-04
Identities = 63/315 (20%), Positives = 130/315 (41%), Gaps = 55/315 (17%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL-TQVVSLVVEREKQKSEAKDRKVL 163
L+++L LK+ Q E V L ++L TN L T+ + R+ Q +K + L
Sbjct: 536 LKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQL 595
Query: 164 E-----------ILQVKDAKIQ-EFEQRESVLKQE----------INDLVKRKIAVDE-- 199
E +L+ K++ EF +S L+ E INDL R ++E
Sbjct: 596 ESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDL 655
Query: 200 ------------ENAFLRKEFSDLEKKFK----DKSQEIKDTKECVQNKEEQNRLVIKNL 243
E L++ F+DLEK+ D + ++K ++ ++ +E +++ L
Sbjct: 656 KNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARL 715
Query: 244 EEENK---KLSTRCTDLLNDLEKLRKQEAHLRKEKYS-----------TDAKIKTFEDNL 289
++NK + ++ + ++EK +E L+++ + D +K + +
Sbjct: 716 ADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKI 775
Query: 290 IEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQA 349
E K+ +V L+L++ + + D+ + +++ L+ KQ
Sbjct: 776 NELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLM 835
Query: 350 ELIQQLQVLNMDTQK 364
E+ L+ N + +K
Sbjct: 836 EMKMNLEKQNAELRK 850
Score = 40.0 bits (92), Expect = 0.004
Identities = 43/229 (18%), Positives = 90/229 (39%), Gaps = 10/229 (4%)
Query: 150 REKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFS 209
RE +++ + + +Q K ++E E K+E+ K E+ A +E
Sbjct: 429 RETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEI 488
Query: 210 DLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEA 269
L K + ++++ K +Q+K + + + ++ + L L + LE L+K+
Sbjct: 489 TLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQ 548
Query: 270 H----------LRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
+ L+++ T+A ++T D RK S + L + Q +
Sbjct: 549 NSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCL 608
Query: 320 KDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRN 368
+ + KE LQ+ + +E+I LQ ++ L+N
Sbjct: 609 LETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKN 657
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 62.0 bits (149), Expect = 9e-10
Identities = 80/330 (24%), Positives = 145/330 (43%), Gaps = 43/330 (13%)
Query: 87 RRLEGISVEEAMVTRTQLLEEEL--SSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVV 144
++ E S+E+ + L+EE+ S E+ AL A ++ + L ++L+ + +
Sbjct: 707 QKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATL 766
Query: 145 ----SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEE 200
S +ER EAK R+V+ LQ KIQE +Q+E Q+ V+ + V ++
Sbjct: 767 EKEHSAELERLCSSLEAKHREVVSSLQ---KKIQEAQQKEEAQLQKCLGQVEHR--VHQK 821
Query: 201 NAFLRKEFSDLEKKFKDKSQEIKDTKE--CVQNKEEQNRLVIKNLE----EENKKLSTRC 254
+ + +L ++K QE++ E + KEE +++ K E EE K+ +
Sbjct: 822 SYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881
Query: 255 TDLLNDLEKLRK----------QEAH-----LRKEKYSTDAKIKTFEDNLIEARKEV--- 296
L +LE+L++ QE H LR+ + K++ E +L K+V
Sbjct: 882 GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
Query: 297 ----EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELI 352
EV + QL + Q ++ K + T ++L+E Q + Q E++
Sbjct: 942 LALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREIL 1001
Query: 353 QQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
+LQ + L +Q D+ A+S QK
Sbjct: 1002 DELQARKLK----LESQVDLLQAQSQQLQK 1027
Score = 42.0 bits (97), Expect = 0.001
Identities = 75/308 (24%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALC-------QADKEFVWSLWKRLQV---TNPDLTQV- 143
EE ++ Q E+ LSSL+E L ++E W R QV T D Q+
Sbjct: 630 EEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIR 689
Query: 144 ----VSLVVEREKQKS---------EAKDRKVLEILQVKDAKIQEFEQ------RESVLK 184
SL RE+ +S E K+R++LE L+ + ++ EQ +E L+
Sbjct: 690 AEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
Query: 185 QEINDLV-KRKIAV----DEENAFLRKEFSDLEKKFKDKSQEI-KDTKECVQNKEEQNRL 238
Q L +RK AV E +A L + S LE K ++ + K +E Q +E Q +
Sbjct: 750 QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK 809
Query: 239 VIKNLEEENKKLSTRCTDLLNDLEKL---RKQEAHLRKEKYSTDAKIKTFEDNLIEARKE 295
+ +E + S ++L L ++QE E+ D + + + +AR++
Sbjct: 810 CLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHER-RLDKMKEEHQQVMAKAREQ 868
Query: 296 VEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
E + K A L + E +Q+ + L ++ + L H Q+ ++L
Sbjct: 869 YEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQE----RKL 924
Query: 356 QVLNMDTQ 363
Q L +D +
Sbjct: 925 QDLELDLE 932
Score = 38.1 bits (87), Expect = 0.014
Identities = 47/210 (22%), Positives = 94/210 (44%), Gaps = 29/210 (13%)
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEF---EQRESVLK------QEINDLVKR-KIAVD 198
E Q E R +LE Q K +++E E+ E +L+ Q ++ L +R + A++
Sbjct: 597 EAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIE 656
Query: 199 EENAFLRKEFSD----LEKKFKDKSQEIKDTKECVQNK---------EEQNRLVIKNLEE 245
EE A +R+E S L + + +Q +D Q E Q + +LE+
Sbjct: 657 EEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQ 716
Query: 246 ENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+N+++ + + + EK + + KEK ++ + L RKE + K ++
Sbjct: 717 KNRQMLEQLKEEIEASEKSEQAALNAAKEK-----ALQQLREQLEGERKEAVATLEKEHS 771
Query: 306 LSLQLSNKQTELIQKDMDITLVRKELQELQ 335
L+ E +++ ++ ++K++QE Q
Sbjct: 772 AELERLCSSLEAKHREV-VSSLQKKIQEAQ 800
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 61.6 bits (148), Expect = 1e-09
Identities = 70/298 (23%), Positives = 133/298 (44%), Gaps = 20/298 (6%)
Query: 86 SRRLEGISVEEAMVTRTQLLEEELSSLKEELAL-CQADKEFVWSLWKRLQVTNPDLTQVV 144
SR+ E + E V + QLL+E +KE+L + CQA+K L K+++ D+ + V
Sbjct: 1977 SRQKEAMKAEAGPVEQ-QLLQETEKLMKEKLEVQCQAEKVRD-DLQKQVKALEIDVEEQV 2034
Query: 145 SLVVERE----------KQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRK 194
S +E E +Q+++A ++++ ++ + D + + E V +QEI L ++
Sbjct: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
Query: 195 IAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254
V + ++E+ ++ E + +KE+ R I+ EE +KL R
Sbjct: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR-DIQERNEEIEKLEFRV 2153
Query: 255 TDLLNDL--EKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSN 312
+L L E + A K + S + +++ D + KE+ + + +L N
Sbjct: 2154 RELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2213
Query: 313 KQTELIQKDMDITLVRKE----LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVL 366
K E+ Q M + + +KE LQEL+ K + I++ ++ Q VL
Sbjct: 2214 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVL 2271
Score = 54.7 bits (130), Expect = 1e-07
Identities = 65/283 (22%), Positives = 128/283 (45%), Gaps = 38/283 (13%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ------K 154
+T+LLE+++ + +L A E S+ K + T D+ ++ + V + E+ K
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 155 SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
S++KD +E+ +L +E DL ++ I ++EE R FS EK
Sbjct: 811 SKSKD--------------SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
Query: 215 FKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
F+ QE+++ C+ K + + KN +E K + + L+++ ++
Sbjct: 857 FEVNYQELQEEYACLL-KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915
Query: 275 KYSTDAKIKTF-----------EDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD 323
+ D KTF E + E +++EV++ + LS +LS+ +L QK +
Sbjct: 916 VFDED---KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
Query: 324 ITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM---DTQ 363
I+ + +E++ L+ +Q S + +I + N+ DTQ
Sbjct: 973 ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
Score = 47.4 bits (111), Expect = 2e-05
Identities = 65/277 (23%), Positives = 125/277 (45%), Gaps = 24/277 (8%)
Query: 100 TRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA-K 158
++ + L+EEL + EE Q E L + L + + + + E+E + +EA K
Sbjct: 507 SQKEKLKEELGLILEEKCALQRQLE---DLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEI---NDLVKRKIAVDEENAFLRKEFSDLEKKF 215
+E L+ + E ++E LK E N +K ++ E+NA L D +
Sbjct: 564 SLSTVEDLKAEIVSASE-SRKELELKHEAEVTNYKIKLEMLEKEKNAVL-----DRMAES 617
Query: 216 KDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEK 275
++ E T+ ++EE ++L ++LE E++ L ++L KQ+ + +
Sbjct: 618 QEAELERLRTQLLFSHEEELSKLK-EDLEIEHR---INIEKLKDNLGIHYKQQIDGLQNE 673
Query: 276 YSTDAKIKTFE-DNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
S + FE DNLI + ++ + SK L L N ++E ++TL ELQ+
Sbjct: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727
Query: 335 QNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
+ +Q + +Q+LQ+ +K ++ +E+
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN 764
Score = 47.4 bits (111), Expect = 2e-05
Identities = 75/350 (21%), Positives = 159/350 (45%), Gaps = 91/350 (26%)
Query: 101 RTQLL---EEELSSLKEELAL-----CQADKEFVWSLWKR-LQVTNPDLTQVVSLVVERE 151
RTQLL EEELS LKE+L + + K+ + +K+ + +++Q + + +
Sbjct: 626 RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEK 685
Query: 152 KQKSEAKDRKVLEILQVKDAK------------------------IQEFEQRESVLKQEI 187
+++ +LEI ++KD + +++ E+ + L+QE+
Sbjct: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEV 745
Query: 188 NDLVKRKIAVDEENAFLRKEFSDLEKKF----------KDKSQEIKDTKECVQNKEEQNR 237
+L + ++++ ++++ +DL++KF KD+ + ++D + ++ R
Sbjct: 746 QELQLKTELLEKQ---MKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
Query: 238 LV-----------------IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRK------- 273
L+ I+ L EEN+ L +C L ++EK R + K
Sbjct: 803 LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ 862
Query: 274 ---EKYSTDAKIKTFEDNLIEARKEVEVS-QSKYNALS----LQLSNKQTELIQK---DM 322
E+Y+ K+K D+L +++ + E+ +SK AL+ LQ N T ++ D
Sbjct: 863 ELQEEYACLLKVK---DDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDE 919
Query: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
D T V + L E+ + ++++T EL+++L+V + ++ + D+
Sbjct: 920 DKTFVAETL-EMGEVVEKDTT------ELMEKLEVTKREKLELSQRLSDL 962
Score = 47.4 bits (111), Expect = 2e-05
Identities = 42/217 (19%), Positives = 103/217 (47%), Gaps = 16/217 (7%)
Query: 144 VSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAF 203
++L++E++KQ +K+ + DA++ E + R L+ + ++ E
Sbjct: 3251 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ----------VLLESEKVR 3300
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEE-QNRLVIKNLEEENKKLSTRCTDLLNDLE 262
+R+ S L+++ ++ +++ + Q++ + ++K L+++ ++ +R +LLN+ E
Sbjct: 3301 IREMSSTLDRE-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE 3359
Query: 263 KLRKQEAHLR----KEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
K + R K++ ++T ++ E +K++ QSK L QL K+ ++
Sbjct: 3360 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3419
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
+ D++ ++ +QE Q + + L Q L
Sbjct: 3420 KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456
Score = 46.2 bits (108), Expect = 5e-05
Identities = 51/254 (20%), Positives = 119/254 (46%), Gaps = 22/254 (8%)
Query: 140 LTQVVSLVVEREKQKSEAKDRKVLEI------LQVKDAKIQEFEQ-RESVLKQEINDLVK 192
+TQ+ + + + ++K E R+ LE+ LQ++ ++Q E R S DL++
Sbjct: 207 ITQLTANLQQARREKDETM-REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265
Query: 193 RKIAVDEENAFLRKE---FSDLEKKFKDKSQEIKDTKECVQNKE-EQNRLVIKNLEEENK 248
K + L ++ D +KK +D + +I +E ++ E EQ++ V + +EE +
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 249 KLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSL 308
+ T +L + + K+ L+ + + D + ++ +++ +E++ + L
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK-------NMKL 378
Query: 309 QLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRN 368
+L+N + + Q +I + ++ELQ K+N + + +++Q+++ + LR
Sbjct: 379 ELTNSKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRA 435
Query: 369 QEDVHTAESISYQK 382
+ D + I K
Sbjct: 436 ELDEMYGQQIVQMK 449
Score = 45.4 bits (106), Expect = 9e-05
Identities = 56/294 (19%), Positives = 136/294 (46%), Gaps = 29/294 (9%)
Query: 108 ELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQ 167
+L K+++ Q E L + Q D T +S + E+ K +D+K
Sbjct: 262 DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKK------ 315
Query: 168 VKDAKIQEFEQRESVLKQ---EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
V+++ +E +++E+++++ +I + K+ + + ++ K +L+++ K+QEIK+
Sbjct: 316 VENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN 375
Query: 225 TKECVQNKEEQNRL----------VIKNLEEENKKLSTRCTDLLNDLE-----KLRKQEA 269
K + N +++ R ++ L++ N K S TD++ +E KL + A
Sbjct: 376 MKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA 435
Query: 270 HLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK 329
L E Y ++ ++ + + ++E ++++ + + + I L+
Sbjct: 436 EL-DEMYGQQI-VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493
Query: 330 ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKV 383
+ EL N+ Q++ +Q+ +L ++L ++ + + R ED+ S S +++
Sbjct: 494 AINEL-NIKLQDT--NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQI 544
Score = 45.1 bits (105), Expect = 1e-04
Identities = 67/324 (20%), Positives = 150/324 (46%), Gaps = 49/324 (15%)
Query: 90 EGISVEEAMVTR--TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQV-VSL 146
E I +E ++ T+++EEE +L+ + L ADK + L +++ N ++ + + L
Sbjct: 322 EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK-LLGELQEQIVQKNQEIKNMKLEL 380
Query: 147 VVEREKQKSEAKDRKVL----EILQVKDAKIQEFE------------QRESVLKQEINDL 190
++K++ +++ K L E LQ ++ K +FE ++ L+ E++++
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
Query: 191 VKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQN---KEEQNRLVIKNLEEEN 247
++I V + +R+ + +E+ E+++ N E+Q +L+ + E N
Sbjct: 441 YGQQI-VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
Query: 248 KKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLI-------EARKEVEVSQ 300
KL D + EKL+++ + +EK + +++ + L AR+ + +
Sbjct: 500 IKLQ----DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQ------------ELQNLYKQNSTHTAQQ 348
SK N LS + +L + + + RKEL+ +L+ L K+ + +
Sbjct: 556 SKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM 614
Query: 349 AELIQQLQVLNMDTQKVLRNQEDV 372
AE Q+ ++ + TQ + ++E++
Sbjct: 615 AE-SQEAELERLRTQLLFSHEEEL 637
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/228 (20%), Positives = 108/228 (47%), Gaps = 18/228 (7%)
Query: 146 LVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRK--IAVDEENAF 203
L++ +E+ + + ++R E ++ + +++E EQ V ++ V+ K ++++ +
Sbjct: 2128 LLLSKEQLQRDIQERN--EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK 263
R EK+ + ++++ +E ++NK E+ + + LE + K+ +TR +L + +
Sbjct: 2186 ERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKL 2245
Query: 264 LRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD 323
+ L +DA + +D + K ++ Q K + + N+Q +Q+ +
Sbjct: 2246 FKDDMEKLGLAIKESDA--MSTQDQHVLFGKFAQIIQEK--EVEIDQLNEQVTKLQQQLK 2301
Query: 324 ITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
IT K ++E L + +L Q++ L D + V RN+E+
Sbjct: 2302 ITTDNKVIEEKNELIR----------DLETQIECLMSDQECVKRNREE 2339
Score = 44.7 bits (104), Expect = 1e-04
Identities = 65/301 (21%), Positives = 138/301 (45%), Gaps = 32/301 (10%)
Query: 89 LEGIS-----VEEAMVTRTQLLEEELSSLKE--ELALCQAD-KEFVWSLWKRLQVTNPDL 140
LE IS +E A VT+T+L+ E +E E CQ + +E + + + +L
Sbjct: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVEL 1917
Query: 141 TQVVSLV---------VERE-KQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDL 190
++ ++ ER+ ++K++ DR E+L + ++QE E + +++E L
Sbjct: 1918 SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASN-RLQELEAEQQQIQEERELL 1976
Query: 191 VKRKIAVDEENAFLRKE-FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKK 249
++K A+ E + ++ + EK K+K + ++ + ++Q + + ++EE+ +
Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSR 2036
Query: 250 LSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ 309
+ +L LR+Q L K+ + K ++ I+ E +V Q + L Q
Sbjct: 2037 FIELEQEKNTELMDLRQQNQALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
Query: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
L +++ + I+ + +E++ L T + +EL+ + L D Q+ RN+
Sbjct: 2094 L-----KVVPRFQPIS--EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQE--RNE 2144
Query: 370 E 370
E
Sbjct: 2145 E 2145
Score = 38.9 bits (89), Expect = 0.008
Identities = 42/216 (19%), Positives = 101/216 (46%), Gaps = 17/216 (7%)
Query: 139 DLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEI-NDLVKRKIAV 197
++ Q S ++E + + S KDR ++QE E ++ E+ ++L + K+ +
Sbjct: 3117 NIQQKQSQMLEMQVELSSMKDRAT---------ELQEQLSSEKMVVAELKSELAQTKLEL 3167
Query: 198 DEENAFLRKEFSDLEK---KFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254
+ K +LE + KDK+ E+ + + ++++++R + LE+E KL
Sbjct: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227
Query: 255 TDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQ 314
+LE L+ ++ + ++ + L E+++++E + Y+A QLS +Q
Sbjct: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA---QLSEEQ 3284
Query: 315 TELIQKDMDITLVRKELQELQN-LYKQNSTHTAQQA 349
++ + + + ++E+ + L ++ H Q+
Sbjct: 3285 GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQS 3320
Score = 37.0 bits (84), Expect = 0.031
Identities = 51/237 (21%), Positives = 108/237 (45%), Gaps = 44/237 (18%)
Query: 172 KIQEFEQRESVLKQEINDLVKRKIAVD-------EENAFLRKE-------FSDLEKKFKD 217
K+Q+ ++ LK+E+ +++ K A+ EE +F R++ ++ E K +
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 218 KSQE---IKDTK-ECVQNKEEQNRLVIKN-------------LEEENKKLSTRCTDLLN- 259
+ ++D K E V E + L +K+ LE+E + R +
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Query: 260 DLEKLRKQ-----EAHLRKEKYSTDAK----IKTFEDNL-IEARKEVEVSQSKYNALSLQ 309
+LE+LR Q E L K K + + I+ +DNL I +++++ Q++ +
Sbjct: 621 ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIET 680
Query: 310 LSNKQTELIQKDMDITLVRKELQELQN--LYKQNSTHTAQQAELIQQLQVLNMDTQK 364
+ ++ LI K + L +L++LQ + ++ T Q EL +++++L + ++
Sbjct: 681 MQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
Score = 36.6 bits (83), Expect = 0.040
Identities = 69/368 (18%), Positives = 145/368 (39%), Gaps = 92/368 (25%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK------------ 152
LEE+L +EEL + E V L +L++ + T + + + K
Sbjct: 2200 LEEQLEQFREEL---ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2256
Query: 153 -QKSEA---KDRKVL-----EILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAF 203
++S+A +D+ VL +I+Q K+ +I + ++ + L+Q++ K+ ++E+N
Sbjct: 2257 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV-IEEKNEL 2315
Query: 204 LRKE-------FSDLEKKFKDKSQEIKDTKECVQNKEEQ-------NRLVIKNLEEEN-- 247
+R SD E +++ +EI+ E ++ +++ + +L EE
Sbjct: 2316 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADS 2375
Query: 248 ---------------------------------KKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K+ + + L +L L+++ + K
Sbjct: 2376 LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2435
Query: 275 KYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ---------------LSNKQTELIQ 319
+ + + D+L + + E+EV ++ SL+ + N +T L+Q
Sbjct: 2436 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQ 2495
Query: 320 KDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESIS 379
++ T+ K+L EL YKQ Q + LQ ++ QK++ + I
Sbjct: 2496 --LESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2552
Query: 380 YQKVCFYS 387
+ V Y+
Sbjct: 2553 LEAVQEYA 2560
Score = 34.3 bits (77), Expect = 0.20
Identities = 62/276 (22%), Positives = 118/276 (42%), Gaps = 55/276 (19%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
++ L SLKEEL Q +K +L ++ L ++ K + + K L +
Sbjct: 1140 DKALCSLKEELIFAQEEK-------------IKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Query: 166 LQVKDAKIQEFEQRE---------SVLKQEINDLVKRKI-AVDEENAFLRKEFSDLEKKF 215
L K+Q+ E SVL + +K ++ A D+EN+ D +
Sbjct: 1187 L---IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS------GDYISEN 1237
Query: 216 KDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEK 275
+D E++D + VQ+ +E ++ + EE KL L L K+ Q+
Sbjct: 1238 ED--PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV----LQTRLSKIWGQQ------- 1284
Query: 276 YSTDAKIKTFEDNLIEARKE-VEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+ K++ E+NL + E + + N + +++K +D++ T + +++QEL
Sbjct: 1285 -TDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
Query: 335 QNL---YKQNSTHTAQQAE-----LIQQLQVLNMDT 362
++L +Q T Q E L ++LQ ++ T
Sbjct: 1344 ESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379
Score = 34.3 bits (77), Expect = 0.20
Identities = 51/272 (18%), Positives = 120/272 (44%), Gaps = 36/272 (13%)
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
T+LL+ E + ++L L Q K+ K +Q T+++ + ++ E K
Sbjct: 2491 TRLLQLESTVSAKDLELTQCYKQI-----KDMQEQGQFETEMLQKKIVNLQKIVEEKVAA 2545
Query: 162 VLEILQVKDAKIQEF----EQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
L + Q++ +QE+ + +++ + ++ + E+ L + S L + +
Sbjct: 2546 AL-VSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE--LGSDISALTLRISE 2602
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
++ + + ++EQ + KN+ E+ KKL +L LE K++ K++
Sbjct: 2603 LESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL----LELQKLLEGNEKKQREKEKKRSP 2658
Query: 278 TDAKIKTFEDNLIEARKE------VEVSQSKYNALSLQLSNK-------QTELIQKDMDI 324
D ++ L + +E +E +++ A +L++ Q EL+ K+ ++
Sbjct: 2659 QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNM 2718
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAELIQQLQ 356
T ++K+L ++++ H A+ E + L+
Sbjct: 2719 TSLQKDLSQVRD-------HLAEAKEKLSILE 2743
Score = 30.8 bits (68), Expect = 2.2
Identities = 48/250 (19%), Positives = 108/250 (43%), Gaps = 27/250 (10%)
Query: 133 LQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVK 192
L+ + + QV+SL E S+ +D + ++ + + + + S LK I +
Sbjct: 2939 LRAVHNEGMQVLSLT---ESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 2995
Query: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
++ A +++ + FSD + Q++ EE++ L+ E +T
Sbjct: 2996 QREAEVYDSSQSHESFSDWRGELLLALQQVF--------LEERSVLLAAFRTELTALGTT 3047
Query: 253 RCTDLLNDLE-KLRKQ--------EAHLRKEKYSTDAKIKTFEDNL----IEARKEVEVS 299
LLN LE ++++Q E + ++ S ++I+ + I ++E E
Sbjct: 3048 DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE 3107
Query: 300 QSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLN 359
+ L + KQ+++++ ++++ ++ ELQ +Q S+ AEL +L
Sbjct: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ---EQLSSEKMVVAELKSELAQTK 3164
Query: 360 MDTQKVLRNQ 369
++ + L+ Q
Sbjct: 3165 LELETTLKAQ 3174
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 61.2 bits (147), Expect = 2e-09
Identities = 68/294 (23%), Positives = 136/294 (46%), Gaps = 37/294 (12%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
M R Q LE E++ K+E + QA ++ +++ ++ E E +K++
Sbjct: 733 MSDRIQHLEREITRYKDESSKAQA-----------------EVDRLLEILKEVENEKND- 774
Query: 158 KDRKVLEI-LQVKD--AKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
KD+K+ E+ QVKD K+ + +E V K++ +++ ++ ++ D +K
Sbjct: 775 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 834
Query: 215 FKDKSQEIKDT-KECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRK 273
D+ +E+++ +E VQ E+ +V+ E + +LL +EK++++ ++
Sbjct: 835 KDDRIEELEEALRESVQITAER-EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKA 893
Query: 274 EKYSTDAKIKTFEDNLIEARKE-----VEVSQSKYNALSLQLSNKQTELIQKDMDITLVR 328
+ ST + E +L R E EV + K AL +S K + ++++ +
Sbjct: 894 KLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL--LELSSSK 951
Query: 329 KELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLR-NQEDVHTAESISYQ 381
K+ QE K+ ++ L+QQL+ + K++ N ED H S S Q
Sbjct: 952 KKTQEEVAALKR------EKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 999
Score = 60.5 bits (145), Expect = 3e-09
Identities = 62/268 (23%), Positives = 117/268 (43%), Gaps = 32/268 (11%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQK-SEAKDRKVL 163
LEEE+ LK AL ++E ++ + V R K + K ++
Sbjct: 401 LEEEIQMLKSNGALSTEERE----------------EEMKQMEVYRSHSKFMKNKVEQLK 444
Query: 164 EILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIK 223
E L K+A+ +E +++ + L+ EI + + D E L+ + L +F D Q I+
Sbjct: 445 EELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIE 504
Query: 224 DTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIK 283
KE + KE++ + L+ E L R + L K KQ + +EK + +I
Sbjct: 505 VLKESLTAKEQRAAI----LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
Query: 284 TFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNST 343
+D L +V + K N L ++ N Q +L K+ ++ +++ ++ LQ ++T
Sbjct: 561 DLKDML-------DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ----ADTT 609
Query: 344 HTAQQAELIQQLQVLNMDTQKVLRNQED 371
+T +++ T + L+ Q D
Sbjct: 610 NTDTALTTLEEALAEKERTIERLKEQRD 637
Score = 55.1 bits (131), Expect = 1e-07
Identities = 60/312 (19%), Positives = 140/312 (44%), Gaps = 40/312 (12%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQAD------KEFVWSLWKRLQVTNPDLTQVVSLV 147
+E + T+ Q L S+K+ L + Q+ E +RL + + SL+
Sbjct: 291 MELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL 350
Query: 148 VEREKQKS---------------EAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVK 192
++EK+ S AK + + ++++KD+KI E+ L++EI L
Sbjct: 351 EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML-- 408
Query: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
+ N L E + E K + + + + ++NK EQ + + + E + ++L
Sbjct: 409 ------KSNGALSTEEREEEMK---QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK 459
Query: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSN 312
+ L ++ +++++ + E + K++T + ++++ +EV + A + +
Sbjct: 460 KAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAI 519
Query: 313 KQTEL----IQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQV----LNMDTQK 364
QTE+ ++ + T++ K+ +++Q++ ++ T + +L L V +N+ +K
Sbjct: 520 LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 579
Query: 365 VLRNQEDVHTAE 376
+ QE + E
Sbjct: 580 IENLQEQLRDKE 591
Score = 45.4 bits (106), Expect = 9e-05
Identities = 49/222 (22%), Positives = 105/222 (47%), Gaps = 17/222 (7%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNP--DLTQVVSLVVEREKQKSEAKDRKV 162
L+ E+ +K+EL+ + D E + K +TN D Q + ++ K+ AK+++
Sbjct: 464 LQAEIGQVKQELS--RKDTELLALQTKLETLTNQFSDSKQHIEVL----KESLTAKEQRA 517
Query: 163 LEILQVKDAKIQEFEQRESVLKQ---EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
+ DA E++E++L + +I D+ + K E L+ E+K
Sbjct: 518 AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 577
Query: 220 QEIKDTKECVQNKEEQNRLV---IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKY 276
++I++ +E +++KE+Q + +K+L+ + T T L E L ++E + + K
Sbjct: 578 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL---EEALAEKERTIERLKE 634
Query: 277 STDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
D + ++ + +K+++ + K + L LS K+ L+
Sbjct: 635 QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLL 676
Score = 35.4 bits (80), Expect = 0.089
Identities = 38/164 (23%), Positives = 74/164 (45%), Gaps = 14/164 (8%)
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+ I D + ++ +N L+ K++E + KLS+ + K+E LRK++ S
Sbjct: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEAS 206
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNAL--SLQLSNKQTELIQKDMDITLVRKELQEL- 334
KI +++ ++E + Q AL L++ +L Q+D + EL
Sbjct: 207 ---KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT 263
Query: 335 -QNLYKQNSTHTAQQAEL------IQQLQVLNMDTQKVLRNQED 371
+N + ++ H Q EL +++++ L ++TQK N D
Sbjct: 264 EENFQRLHAEHERQAKELFLLRKTLEEME-LRIETQKQTLNARD 306
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 61.2 bits (147), Expect = 2e-09
Identities = 68/294 (23%), Positives = 136/294 (46%), Gaps = 37/294 (12%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
M R Q LE E++ K+E + QA ++ +++ ++ E E +K++
Sbjct: 705 MSDRIQHLEREITRYKDESSKAQA-----------------EVDRLLEILKEVENEKND- 746
Query: 158 KDRKVLEI-LQVKD--AKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
KD+K+ E+ QVKD K+ + +E V K++ +++ ++ ++ D +K
Sbjct: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
Query: 215 FKDKSQEIKDT-KECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRK 273
D+ +E+++ +E VQ E+ +V+ E + +LL +EK++++ ++
Sbjct: 807 KDDRIEELEEALRESVQITAER-EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKA 865
Query: 274 EKYSTDAKIKTFEDNLIEARKE-----VEVSQSKYNALSLQLSNKQTELIQKDMDITLVR 328
+ ST + E +L R E EV + K AL +S K + ++++ +
Sbjct: 866 KLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL--LELSSSK 923
Query: 329 KELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLR-NQEDVHTAESISYQ 381
K+ QE K+ ++ L+QQL+ + K++ N ED H S S Q
Sbjct: 924 KKTQEEVAALKR------EKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQ 971
Score = 50.4 bits (119), Expect = 3e-06
Identities = 71/334 (21%), Positives = 132/334 (39%), Gaps = 71/334 (21%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQAD------KEFVWSLWKRLQVTNPDLTQVVSLV 147
+E + T+ Q L S+K+ L + Q+ E +RL + + SL+
Sbjct: 291 MELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL 350
Query: 148 VEREKQKS---------------EAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDL-- 190
++EK+ S AK + + ++++KD+KI E+ L++EI L
Sbjct: 351 EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
Query: 191 -------------------------VKRKIA--------VDEENAFLRKEFSDLEKKFKD 217
+K KI D E L+ + L +F D
Sbjct: 411 NGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD 470
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
Q I+ KE + KE++ + L+ E L R + L K KQ + +EK +
Sbjct: 471 SKQHIEVLKESLTAKEQRAAI----LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL 337
+I +D L +V + K N L ++ N Q +L K+ ++ +++ ++ LQ
Sbjct: 527 QAGEIHDLKDML-------DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ-- 577
Query: 338 YKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
++T+T +++ T + L+ Q D
Sbjct: 578 --ADTTNTDTALTTLEEALAEKERTIERLKEQRD 609
Score = 45.4 bits (106), Expect = 9e-05
Identities = 50/239 (20%), Positives = 112/239 (46%), Gaps = 17/239 (7%)
Query: 88 RLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNP--DLTQVVS 145
R E + E + ++ ++ ++ +K+EL+ + D E + K +TN D Q +
Sbjct: 419 REEEMKQMEVYRSHSKFMKNKIGQVKQELS--RKDTELLALQTKLETLTNQFSDSKQHIE 476
Query: 146 LVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQ---EINDLVKRKIAVDEENA 202
++ K+ AK+++ + DA E++E++L + +I D+ + K E
Sbjct: 477 VL----KESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
Query: 203 FLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLV---IKNLEEENKKLSTRCTDLLN 259
L+ E+K ++I++ +E +++KE+Q + +K+L+ + T T L
Sbjct: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL-- 590
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
E L ++E + + K D + ++ + +K+++ + K + L LS K+ L+
Sbjct: 591 -EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLL 648
Score = 35.4 bits (80), Expect = 0.089
Identities = 38/164 (23%), Positives = 74/164 (45%), Gaps = 14/164 (8%)
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+ I D + ++ +N L+ K++E + KLS+ + K+E LRK++ S
Sbjct: 147 RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEAS 206
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNAL--SLQLSNKQTELIQKDMDITLVRKELQEL- 334
KI +++ ++E + Q AL L++ +L Q+D + EL
Sbjct: 207 ---KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT 263
Query: 335 -QNLYKQNSTHTAQQAEL------IQQLQVLNMDTQKVLRNQED 371
+N + ++ H Q EL +++++ L ++TQK N D
Sbjct: 264 EENFQRLHAEHERQAKELFLLRKTLEEME-LRIETQKQTLNARD 306
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 61.2 bits (147), Expect = 2e-09
Identities = 71/305 (23%), Positives = 135/305 (44%), Gaps = 26/305 (8%)
Query: 86 SRRLEGISVEEAMVTRTQLLEEELSSLKEELAL-CQADKEFVWSLWKRLQVTNPDLTQVV 144
SR+ E + E V + QLL+E +KE+L + CQA+K L K+++ D+ + V
Sbjct: 1977 SRQKEAMKAEAGPVEQ-QLLQETEKLMKEKLEVQCQAEKVRD-DLQKQVKALEIDVEEQV 2034
Query: 145 SLVVERE----------KQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDL---- 190
S +E E +Q+++A ++++ ++ + D + + E V +QEI L
Sbjct: 2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQL 2094
Query: 191 --VKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENK 248
V R + E ++ ++ K+ DK E+ +KE +Q ++ I+ LE +
Sbjct: 2095 KVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Query: 249 KLSTR---CTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+L D +E + A K + S + +++ D + KE+ + +
Sbjct: 2155 ELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2214
Query: 306 LSLQLSNKQTELIQKDMDITLVRKE----LQELQNLYKQNSTHTAQQAELIQQLQVLNMD 361
+L NK E+ Q M + + +KE LQEL+ K + I++ ++
Sbjct: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2274
Query: 362 TQKVL 366
Q VL
Sbjct: 2275 DQHVL 2279
Score = 54.7 bits (130), Expect = 1e-07
Identities = 65/283 (22%), Positives = 128/283 (45%), Gaps = 38/283 (13%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ------K 154
+T+LLE+++ + +L A E S+ K + T D+ ++ + V + E+ K
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 155 SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
S++KD +E+ +L +E DL ++ I ++EE R FS EK
Sbjct: 811 SKSKD--------------SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856
Query: 215 FKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
F+ QE+++ C+ K + + KN +E K + + L+++ ++
Sbjct: 857 FEVNYQELQEEYACLL-KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915
Query: 275 KYSTDAKIKTF-----------EDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD 323
+ D KTF E + E +++EV++ + LS +LS+ +L QK +
Sbjct: 916 VFDED---KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972
Query: 324 ITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM---DTQ 363
I+ + +E++ L+ +Q S + +I + N+ DTQ
Sbjct: 973 ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
Score = 47.4 bits (111), Expect = 2e-05
Identities = 65/277 (23%), Positives = 125/277 (45%), Gaps = 24/277 (8%)
Query: 100 TRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA-K 158
++ + L+EEL + EE Q E L + L + + + + E+E + +EA K
Sbjct: 507 SQKEKLKEELGLILEEKCALQRQLE---DLVEELSFSREQIQRARQTIAEQESKLNEAHK 563
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEI---NDLVKRKIAVDEENAFLRKEFSDLEKKF 215
+E L+ + E ++E LK E N +K ++ E+NA L D +
Sbjct: 564 SLSTVEDLKAEIVSASE-SRKELELKHEAEVTNYKIKLEMLEKEKNAVL-----DRMAES 617
Query: 216 KDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEK 275
++ E T+ ++EE ++L ++LE E++ L ++L KQ+ + +
Sbjct: 618 QEAELERLRTQLLFSHEEELSKLK-EDLEIEHR---INIEKLKDNLGIHYKQQIDGLQNE 673
Query: 276 YSTDAKIKTFE-DNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
S + FE DNLI + ++ + SK L L N ++E ++TL ELQ+
Sbjct: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727
Query: 335 QNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
+ +Q + +Q+LQ+ +K ++ +E+
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN 764
Score = 47.4 bits (111), Expect = 2e-05
Identities = 75/350 (21%), Positives = 159/350 (45%), Gaps = 91/350 (26%)
Query: 101 RTQLL---EEELSSLKEELAL-----CQADKEFVWSLWKR-LQVTNPDLTQVVSLVVERE 151
RTQLL EEELS LKE+L + + K+ + +K+ + +++Q + + +
Sbjct: 626 RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEK 685
Query: 152 KQKSEAKDRKVLEILQVKDAK------------------------IQEFEQRESVLKQEI 187
+++ +LEI ++KD + +++ E+ + L+QE+
Sbjct: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEV 745
Query: 188 NDLVKRKIAVDEENAFLRKEFSDLEKKF----------KDKSQEIKDTKECVQNKEEQNR 237
+L + ++++ ++++ +DL++KF KD+ + ++D + ++ R
Sbjct: 746 QELQLKTELLEKQ---MKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
Query: 238 LV-----------------IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRK------- 273
L+ I+ L EEN+ L +C L ++EK R + K
Sbjct: 803 LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ 862
Query: 274 ---EKYSTDAKIKTFEDNLIEARKEVEVS-QSKYNALS----LQLSNKQTELIQK---DM 322
E+Y+ K+K D+L +++ + E+ +SK AL+ LQ N T ++ D
Sbjct: 863 ELQEEYACLLKVK---DDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDE 919
Query: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
D T V + L E+ + ++++T EL+++L+V + ++ + D+
Sbjct: 920 DKTFVAETL-EMGEVVEKDTT------ELMEKLEVTKREKLELSQRLSDL 962
Score = 47.4 bits (111), Expect = 2e-05
Identities = 42/217 (19%), Positives = 103/217 (47%), Gaps = 16/217 (7%)
Query: 144 VSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAF 203
++L++E++KQ +K+ + DA++ E + R L+ + ++ E
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ----------VLLESEKVR 3308
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEE-QNRLVIKNLEEENKKLSTRCTDLLNDLE 262
+R+ S L+++ ++ +++ + Q++ + ++K L+++ ++ +R +LLN+ E
Sbjct: 3309 IREMSSTLDRE-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE 3367
Query: 263 KLRKQEAHLR----KEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
K + R K++ ++T ++ E +K++ QSK L QL K+ ++
Sbjct: 3368 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3427
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQL 355
+ D++ ++ +QE Q + + L Q L
Sbjct: 3428 KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3464
Score = 46.2 bits (108), Expect = 5e-05
Identities = 51/254 (20%), Positives = 119/254 (46%), Gaps = 22/254 (8%)
Query: 140 LTQVVSLVVEREKQKSEAKDRKVLEI------LQVKDAKIQEFEQ-RESVLKQEINDLVK 192
+TQ+ + + + ++K E R+ LE+ LQ++ ++Q E R S DL++
Sbjct: 207 ITQLTANLQQARREKDETM-REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQ 265
Query: 193 RKIAVDEENAFLRKE---FSDLEKKFKDKSQEIKDTKECVQNKE-EQNRLVIKNLEEENK 248
K + L ++ D +KK +D + +I +E ++ E EQ++ V + +EE +
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325
Query: 249 KLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSL 308
+ T +L + + K+ L+ + + D + ++ +++ +E++ + L
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK-------NMKL 378
Query: 309 QLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRN 368
+L+N + + Q +I + ++ELQ K+N + + +++Q+++ + LR
Sbjct: 379 ELTNSKQKERQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQRKLEQLRA 435
Query: 369 QEDVHTAESISYQK 382
+ D + I K
Sbjct: 436 ELDEMYGQQIVQMK 449
Score = 45.8 bits (107), Expect = 7e-05
Identities = 46/221 (20%), Positives = 100/221 (45%), Gaps = 18/221 (8%)
Query: 151 EKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSD 210
E +K E + R++ + L V Q+ E R+ E + ++ + E + ++
Sbjct: 2145 EIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK--- 2201
Query: 211 LEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAH 270
EK+ + ++++ +E ++NK E+ + + LE + K+ +TR +L + + +
Sbjct: 2202 -EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2260
Query: 271 LRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE 330
L +DA + +D + K ++ Q K + + N+Q +Q+ + IT K
Sbjct: 2261 LGLAIKESDA--MSTQDQHVLFGKFAQIIQEK--EVEIDQLNEQVTKLQQQLKITTDNKV 2316
Query: 331 LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
++E L + +L Q++ L D + V RN+E+
Sbjct: 2317 IEEKNELIR----------DLETQIECLMSDQECVKRNREE 2347
Score = 45.4 bits (106), Expect = 9e-05
Identities = 56/294 (19%), Positives = 136/294 (46%), Gaps = 29/294 (9%)
Query: 108 ELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQ 167
+L K+++ Q E L + Q D T +S + E+ K +D+K
Sbjct: 262 DLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKK------ 315
Query: 168 VKDAKIQEFEQRESVLKQ---EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
V+++ +E +++E+++++ +I + K+ + + ++ K +L+++ K+QEIK+
Sbjct: 316 VENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN 375
Query: 225 TKECVQNKEEQNRL----------VIKNLEEENKKLSTRCTDLLNDLE-----KLRKQEA 269
K + N +++ R ++ L++ N K S TD++ +E KL + A
Sbjct: 376 MKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA 435
Query: 270 HLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK 329
L E Y ++ ++ + + ++E ++++ + + + I L+
Sbjct: 436 EL-DEMYGQQI-VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493
Query: 330 ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKV 383
+ EL N+ Q++ +Q+ +L ++L ++ + + R ED+ S S +++
Sbjct: 494 AINEL-NIKLQDT--NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQI 544
Score = 45.1 bits (105), Expect = 1e-04
Identities = 67/324 (20%), Positives = 150/324 (46%), Gaps = 49/324 (15%)
Query: 90 EGISVEEAMVTR--TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQV-VSL 146
E I +E ++ T+++EEE +L+ + L ADK + L +++ N ++ + + L
Sbjct: 322 EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK-LLGELQEQIVQKNQEIKNMKLEL 380
Query: 147 VVEREKQKSEAKDRKVL----EILQVKDAKIQEFE------------QRESVLKQEINDL 190
++K++ +++ K L E LQ ++ K +FE ++ L+ E++++
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440
Query: 191 VKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQN---KEEQNRLVIKNLEEEN 247
++I V + +R+ + +E+ E+++ N E+Q +L+ + E N
Sbjct: 441 YGQQI-VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
Query: 248 KKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLI-------EARKEVEVSQ 300
KL D + EKL+++ + +EK + +++ + L AR+ + +
Sbjct: 500 IKLQ----DTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQ------------ELQNLYKQNSTHTAQQ 348
SK N LS + +L + + + RKEL+ +L+ L K+ + +
Sbjct: 556 SKLNEAHKSLSTVE-DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM 614
Query: 349 AELIQQLQVLNMDTQKVLRNQEDV 372
AE Q+ ++ + TQ + ++E++
Sbjct: 615 AE-SQEAELERLRTQLLFSHEEEL 637
Score = 44.7 bits (104), Expect = 1e-04
Identities = 65/301 (21%), Positives = 138/301 (45%), Gaps = 32/301 (10%)
Query: 89 LEGIS-----VEEAMVTRTQLLEEELSSLKE--ELALCQAD-KEFVWSLWKRLQVTNPDL 140
LE IS +E A VT+T+L+ E +E E CQ + +E + + + +L
Sbjct: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVEL 1917
Query: 141 TQVVSLV---------VERE-KQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDL 190
++ ++ ER+ ++K++ DR E+L + ++QE E + +++E L
Sbjct: 1918 SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASN-RLQELEAEQQQIQEERELL 1976
Query: 191 VKRKIAVDEENAFLRKE-FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKK 249
++K A+ E + ++ + EK K+K + ++ + ++Q + + ++EE+ +
Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSR 2036
Query: 250 LSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ 309
+ +L LR+Q L K+ + K ++ I+ E +V Q + L Q
Sbjct: 2037 FIELEQEKNTELMDLRQQNQALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093
Query: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
L +++ + I+ + +E++ L T + +EL+ + L D Q+ RN+
Sbjct: 2094 L-----KVVPRFQPIS--EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQE--RNE 2144
Query: 370 E 370
E
Sbjct: 2145 E 2145
Score = 38.9 bits (89), Expect = 0.008
Identities = 42/216 (19%), Positives = 101/216 (46%), Gaps = 17/216 (7%)
Query: 139 DLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEI-NDLVKRKIAV 197
++ Q S ++E + + S KDR ++QE E ++ E+ ++L + K+ +
Sbjct: 3125 NIQQKQSQMLEMQVELSSMKDRAT---------ELQEQLSSEKMVVAELKSELAQTKLEL 3175
Query: 198 DEENAFLRKEFSDLEK---KFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC 254
+ K +LE + KDK+ E+ + + ++++++R + LE+E KL
Sbjct: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3235
Query: 255 TDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQ 314
+LE L+ ++ + ++ + L E+++++E + Y+A QLS +Q
Sbjct: 3236 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA---QLSEEQ 3292
Query: 315 TELIQKDMDITLVRKELQELQN-LYKQNSTHTAQQA 349
++ + + + ++E+ + L ++ H Q+
Sbjct: 3293 GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQS 3328
Score = 37.0 bits (84), Expect = 0.031
Identities = 51/237 (21%), Positives = 108/237 (45%), Gaps = 44/237 (18%)
Query: 172 KIQEFEQRESVLKQEINDLVKRKIAVD-------EENAFLRKE-------FSDLEKKFKD 217
K+Q+ ++ LK+E+ +++ K A+ EE +F R++ ++ E K +
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 218 KSQE---IKDTK-ECVQNKEEQNRLVIKN-------------LEEENKKLSTRCTDLLN- 259
+ ++D K E V E + L +K+ LE+E + R +
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Query: 260 DLEKLRKQ-----EAHLRKEKYSTDAK----IKTFEDNL-IEARKEVEVSQSKYNALSLQ 309
+LE+LR Q E L K K + + I+ +DNL I +++++ Q++ +
Sbjct: 621 ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIET 680
Query: 310 LSNKQTELIQKDMDITLVRKELQELQN--LYKQNSTHTAQQAELIQQLQVLNMDTQK 364
+ ++ LI K + L +L++LQ + ++ T Q EL +++++L + ++
Sbjct: 681 MQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
Score = 36.6 bits (83), Expect = 0.040
Identities = 69/368 (18%), Positives = 145/368 (39%), Gaps = 92/368 (25%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK------------ 152
LEE+L +EEL + E V L +L++ + T + + + K
Sbjct: 2208 LEEQLEQFREEL---ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2264
Query: 153 -QKSEA---KDRKVL-----EILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAF 203
++S+A +D+ VL +I+Q K+ +I + ++ + L+Q++ K+ ++E+N
Sbjct: 2265 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV-IEEKNEL 2323
Query: 204 LRKE-------FSDLEKKFKDKSQEIKDTKECVQNKEEQ-------NRLVIKNLEEEN-- 247
+R SD E +++ +EI+ E ++ +++ + +L EE
Sbjct: 2324 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADS 2383
Query: 248 ---------------------------------KKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K+ + + L +L L+++ + K
Sbjct: 2384 LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKI 2443
Query: 275 KYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ---------------LSNKQTELIQ 319
+ + + D+L + + E+EV ++ SL+ + N +T L+Q
Sbjct: 2444 QSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQ 2503
Query: 320 KDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESIS 379
++ T+ K+L EL YKQ Q + LQ ++ QK++ + I
Sbjct: 2504 --LESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2560
Query: 380 YQKVCFYS 387
+ V Y+
Sbjct: 2561 LEAVQEYA 2568
Score = 34.3 bits (77), Expect = 0.20
Identities = 62/276 (22%), Positives = 118/276 (42%), Gaps = 55/276 (19%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
++ L SLKEEL Q +K +L ++ L ++ K + + K L +
Sbjct: 1140 DKALCSLKEELIFAQEEK-------------IKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Query: 166 LQVKDAKIQEFEQRE---------SVLKQEINDLVKRKI-AVDEENAFLRKEFSDLEKKF 215
L K+Q+ E SVL + +K ++ A D+EN+ D +
Sbjct: 1187 L---IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS------GDYISEN 1237
Query: 216 KDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEK 275
+D E++D + VQ+ +E ++ + EE KL L L K+ Q+
Sbjct: 1238 ED--PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV----LQTRLSKIWGQQ------- 1284
Query: 276 YSTDAKIKTFEDNLIEARKE-VEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+ K++ E+NL + E + + N + +++K +D++ T + +++QEL
Sbjct: 1285 -TDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343
Query: 335 QNL---YKQNSTHTAQQAE-----LIQQLQVLNMDT 362
++L +Q T Q E L ++LQ ++ T
Sbjct: 1344 ESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379
Score = 34.3 bits (77), Expect = 0.20
Identities = 51/272 (18%), Positives = 120/272 (44%), Gaps = 36/272 (13%)
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
T+LL+ E + ++L L Q K+ K +Q T+++ + ++ E K
Sbjct: 2499 TRLLQLESTVSAKDLELTQCYKQI-----KDMQEQGQFETEMLQKKIVNLQKIVEEKVAA 2553
Query: 162 VLEILQVKDAKIQEF----EQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
L + Q++ +QE+ + +++ + ++ + E+ L + S L + +
Sbjct: 2554 AL-VSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE--LGSDISALTLRISE 2610
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
++ + + ++EQ + KN+ E+ KKL +L LE K++ K++
Sbjct: 2611 LESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL----LELQKLLEGNEKKQREKEKKRSP 2666
Query: 278 TDAKIKTFEDNLIEARKE------VEVSQSKYNALSLQLSNK-------QTELIQKDMDI 324
D ++ L + +E +E +++ A +L++ Q EL+ K+ ++
Sbjct: 2667 QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNM 2726
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAELIQQLQ 356
T ++K+L ++++ H A+ E + L+
Sbjct: 2727 TSLQKDLSQVRD-------HLAEAKEKLSILE 2751
Score = 30.8 bits (68), Expect = 2.2
Identities = 48/250 (19%), Positives = 108/250 (43%), Gaps = 27/250 (10%)
Query: 133 LQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVK 192
L+ + + QV+SL E S+ +D + ++ + + + + S LK I +
Sbjct: 2947 LRAVHNEGMQVLSLT---ESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQL 3003
Query: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLST 252
++ A +++ + FSD + Q++ EE++ L+ E +T
Sbjct: 3004 QREAEVYDSSQSHESFSDWRGELLLALQQVF--------LEERSVLLAAFRTELTALGTT 3055
Query: 253 RCTDLLNDLE-KLRKQ--------EAHLRKEKYSTDAKIKTFEDNL----IEARKEVEVS 299
LLN LE ++++Q E + ++ S ++I+ + I ++E E
Sbjct: 3056 DAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESE 3115
Query: 300 QSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLN 359
+ L + KQ+++++ ++++ ++ ELQ +Q S+ AEL +L
Sbjct: 3116 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ---EQLSSEKMVVAELKSELAQTK 3172
Query: 360 MDTQKVLRNQ 369
++ + L+ Q
Sbjct: 3173 LELETTLKAQ 3182
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 61.2 bits (147), Expect = 2e-09
Identities = 68/304 (22%), Positives = 141/304 (46%), Gaps = 39/304 (12%)
Query: 86 SRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS 145
S+ E + + R + E EL EEL + ++E + + LQ L+++
Sbjct: 656 SQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHD 712
Query: 146 LVVEREKQKSEAKDRKVLEILQVKDAKIQEF----EQRESVLKQEINDLVKRKIAVDEEN 201
+ ++ + K + E+LQ K +Q+ E++E +L++ +L K A+ EE
Sbjct: 713 ELDSAKRSEDREKGALIEELLQAKQ-DLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 202 AFLRKEFSDLEKKFKDKSQEIKDT-KECVQNKE---------EQNR----LVIKNLEEEN 247
+ +E L++++ + Q ++++ +E +N E EQ++ + +K L+EEN
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN 831
Query: 248 KK-------LSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
+K L R L +E L+ EA ++ + +I+ E+ L+ ARKE + +
Sbjct: 832 EKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAV 891
Query: 301 SKYNALSLQL----------SNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAE 350
S AL +L + +Q +L +K + + +++L+ L+N + H + E
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIE 951
Query: 351 LIQQ 354
+Q+
Sbjct: 952 KLQK 955
Score = 48.1 bits (113), Expect = 1e-05
Identities = 68/290 (23%), Positives = 126/290 (43%), Gaps = 36/290 (12%)
Query: 120 QADKEFVWSLWKRLQVTNPDLTQVV--SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFE 177
QA + + + Q TN + + + + + E +A RKV + + KIQ +
Sbjct: 534 QATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFE----KIQTLK 589
Query: 178 QRESVLKQ----------EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKE 227
R + Q E+ DL+++K + E A L+++ LE K Q IK+ +E
Sbjct: 590 SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQ-LEVK---NQQNIKEERE 645
Query: 228 CVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFED 287
++ E+ R EEN L R + +L K ++ ++ E+ +I+ +D
Sbjct: 646 RMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQD 705
Query: 288 NLIEARKEVEVSQ----SKYNALSLQL----SNKQTELIQKDMDITLVRKELQELQ---- 335
L E E++ ++ + AL +L + Q LI K+ L+RK +EL
Sbjct: 706 QLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKG 765
Query: 336 NLYKQNSTHTAQQAELIQQ----LQVLNMDTQKVLRNQEDVHTAESISYQ 381
L ++ S+H + +L +Q LQ L ++ +N E + + + S Q
Sbjct: 766 ALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQ 815
Score = 43.9 bits (102), Expect = 3e-04
Identities = 63/294 (21%), Positives = 123/294 (41%), Gaps = 34/294 (11%)
Query: 102 TQLLEEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSL----VVEREKQKSE 156
++ L+EE S KE+L + + E W L K ++ ++ +V +E + Q E
Sbjct: 919 SEKLKEE-SEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDE 977
Query: 157 AKDRKVLEIL----QVKDAKIQEFEQRESVLK---------QEINDLVKRKIAVDEENAF 203
K++ E+ Q+K+ ++ + R + +K +E+ D + + +
Sbjct: 978 YKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL 1037
Query: 204 LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLND-LE 262
L + DLE + + KS D V+ E++ + LEEE +DLL++ +
Sbjct: 1038 LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNN-----SDLLSERIS 1092
Query: 263 KLRKQEAHLRKEKYSTDAKIKTFE-DNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKD 321
+ R+Q LR E A + E D + R+ ++ + S+K+ ++Q +
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152
Query: 322 MDITLVRKELQ----ELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQED 371
I + L+ + NL N + EL+ Q+ D L +Q+D
Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVD----DEHLSLTDQKD 1202
Score = 35.0 bits (79), Expect = 0.12
Identities = 39/187 (20%), Positives = 84/187 (44%), Gaps = 16/187 (8%)
Query: 107 EELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEIL 166
E++ L+ EL +A ++ + L+ N DL S ++ E +K+ V+++
Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLK---SRIIHLEGSYRSSKEGLVVQM- 1151
Query: 167 QVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTK 226
+A+I E E R L+ E D +++ N L ++ +L + D+ + D K
Sbjct: 1152 ---EARIAELEDR---LESEERDRANLQLS----NRRLERKVKELVMQVDDEHLSLTDQK 1201
Query: 227 ECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS--TDAKIKT 284
+ + + + + ++ EEE +L + L +LE+ HL+ + S D ++K
Sbjct: 1202 DQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKK 1261
Query: 285 FEDNLIE 291
+++
Sbjct: 1262 LPSKVLD 1268
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 60.8 bits (146), Expect = 2e-09
Identities = 39/143 (27%), Positives = 73/143 (51%), Gaps = 6/143 (4%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
EREK+ + K+ ++ E L+ +A+ +E E++ L QE NDL + A + A +
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
L K ++K+ E ++++EE N L + +KL C++L D++ L
Sbjct: 904 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNA----ELTAKKRKLEDECSELKRDIDDLEL 959
Query: 267 QEAHLRKEKYSTDAKIKTFEDNL 289
A + KEK++T+ K+K + +
Sbjct: 960 TLAKVEKEKHATENKVKNLTEEM 982
Score = 54.7 bits (130), Expect = 1e-07
Identities = 71/312 (22%), Positives = 135/312 (43%), Gaps = 37/312 (11%)
Query: 86 SRRLEGISVEEAMVT-RTQLLEEELSSLKEE-------LALCQADKEFVWSLWKRLQVTN 137
+ RLE A +T + + LE+E S LK + LA + +K + K L
Sbjct: 923 NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEM 982
Query: 138 PDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDL-----VK 192
L ++++ + + +K EA ++ L+ LQ ++ K+ + + L+Q+++DL +
Sbjct: 983 AGLDEIIAKLTKEKKALQEAH-QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE 1041
Query: 193 RKIAVDEENA---------FLRKEFSDLE--KKFKDKSQEIKDTK-ECVQNKEEQNRLVI 240
+K+ +D E A ++ DLE K+ D+ + KD + + + E + +
Sbjct: 1042 KKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALG 1101
Query: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
L+++ K+L R +L +LE R A + K + +++ + L EA
Sbjct: 1102 SQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG------- 1154
Query: 301 SKYNALSLQLS-NKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLN 359
A S+Q+ NK+ E + M L LQ H AEL +Q+ L
Sbjct: 1155 ---GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 360 MDTQKVLRNQED 371
QK+ + + +
Sbjct: 1212 RVKQKLEKEKSE 1223
Score = 52.8 bits (125), Expect = 5e-07
Identities = 85/323 (26%), Positives = 140/323 (43%), Gaps = 41/323 (12%)
Query: 87 RRLEG---ISVEEAMVTRT--QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL- 140
R+LEG ++ E M Q L+E L EL A E +L +LQ +L
Sbjct: 1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Query: 141 TQVVSLVVEREKQKS-EAKDRKVLEILQVKDAKIQE-FEQRESVLKQEINDLVKR----- 193
++ L E E +++ AK K+ L + +I E E+ +I KR
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 194 KIAVDEENAFLRKEFSD--LEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLS 251
K+ D E A L+ E + L KK D E+ + + +Q +++ LE+E +
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK-------LEKEKSEFK 1225
Query: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLS 311
D+ +++E++ K +A+L K +T ED + E R + E +Q N L+ Q +
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEK-------MCRTLEDQMNEHRSKAEETQRSVNDLTSQRA 1278
Query: 312 NKQTE-------LIQKDMDIT-LVRKEL---QELQNLYKQNSTHTAQQAELIQQLQVLNM 360
QTE L +K+ I+ L R +L Q+L++L +Q + L LQ
Sbjct: 1279 KLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH 1338
Query: 361 DTQKVLRNQEDVHTAESISYQKV 383
D +LR Q + T Q+V
Sbjct: 1339 DCD-LLREQYEEETEAKAELQRV 1360
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/314 (19%), Positives = 139/314 (44%), Gaps = 47/314 (14%)
Query: 90 EGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL----TQVVS 145
E + + A+ Q + L+E+ + + E L + L N ++ T+ +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQY---EEETEAKAELQRVLSKANSEVAQWRTKYET 1377
Query: 146 LVVEREKQKSEAKDR------KVLEILQVKDAKIQEFEQRESVLKQEINDL---VKRK-- 194
++R ++ EAK + + E ++ +AK E+ + L+ EI DL V+R
Sbjct: 1378 DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437
Query: 195 --IAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKE----------CVQNKEEQNRLVIKN 242
A+D++ K ++ ++K+++ E++ +++ ++N E++ ++
Sbjct: 1438 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1497
Query: 243 LEEENKKLSTRCTDL----------LNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEA 292
+ ENK L +DL +++LEK+RKQ L EK + ++ E +L
Sbjct: 1498 FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ---LEAEKMELQSALEEAEASLEHE 1554
Query: 293 RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLV-RKELQELQNLYKQNSTHTAQQAEL 351
++ +Q ++N + ++ K L +KD ++ R L+ + +L T + E
Sbjct: 1555 EGKILRAQLEFNQIKAEIERK---LAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611
Query: 352 IQQLQVLNMDTQKV 365
++ + + D ++
Sbjct: 1612 LRVKKKMEGDLNEM 1625
Score = 50.4 bits (119), Expect = 3e-06
Identities = 66/279 (23%), Positives = 121/279 (43%), Gaps = 43/279 (15%)
Query: 99 VTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK 158
+T TQ LE+ L+EE+ A L LQ D L+ E+ ++++EAK
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNA-------LAHALQSARHDC----DLLREQYEEETEAK 1354
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
A++Q VL + +++ + + + + +E + +KK +
Sbjct: 1355 ------------AELQR------VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 219 SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
QE ++ E V K +LE+ +L DL+ D+E+ A L K++ +
Sbjct: 1397 LQEAEEAVEAVNAK-------CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF 1449
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALS---LQLSNKQTELIQKDMDITLVRKELQ-EL 334
D + ++ E++ E+E SQ + +LS +L N E ++ K LQ E+
Sbjct: 1450 DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 335 QNLYKQ--NSTHTAQQAELI-QQLQVLNMDTQKVLRNQE 370
+L +Q +S T + E + +QL+ M+ Q L E
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1548
Score = 50.1 bits (118), Expect = 3e-06
Identities = 75/350 (21%), Positives = 137/350 (39%), Gaps = 65/350 (18%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQK 154
EE + R QL E + +K E+ A+K+ KR + D Q SL E +
Sbjct: 1554 EEGKILRAQL---EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT-SLDAETRSRN 1609
Query: 155 SEAKDRKVLE------ILQVKDAKIQEFEQR------ESVLKQ---------EINDLVKR 193
+ +K +E +Q+ A E + +S+LK ND +K
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE 1669
Query: 194 KIA-VDEENAFLRKEFSDL-------EKKFKDKSQEIKDTKECVQNKEEQNRLVI----- 240
IA V+ N L+ E +L E+ K QE+ +T E VQ QN +I
Sbjct: 1670 NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1729
Query: 241 -------------------KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
+N EE+ KK T + +L+K + AHL + K + +
Sbjct: 1730 MDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1789
Query: 282 IKTFEDNLIEA--------RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQE 333
IK + L EA +K+++ +++ L +L +Q + + + ++E
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Query: 334 LQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKV 383
L +++ + + +L+ +LQ+ ++ E+ ++KV
Sbjct: 1850 LTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKV 1899
Score = 43.9 bits (102), Expect = 3e-04
Identities = 55/278 (19%), Positives = 122/278 (43%), Gaps = 52/278 (18%)
Query: 90 EGISVEEAMVTRTQLLEEELSSLKEELALCQ-----ADKEFVWSLWKRLQVTNPDLTQVV 144
E I++ E R LL+ EL L+ + + A++E + + +R+Q+ + +Q
Sbjct: 1669 ENIAIVER---RNNLLQAELEELRAVVEQTERSRKLAEQELIETS-ERVQLLH---SQNT 1721
Query: 145 SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFL 204
SL+ +++K ++ + +V++A +QE E K+ I D + +E
Sbjct: 1722 SLINQKKKMDADLSQLQT----EVEEA-VQECRNAEEKAKKAITDAAMMAEELKKE---- 1772
Query: 205 RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK- 263
+ + LE+ K+ Q IKD + + +E ++ +K +++ +KL R +L N+LE
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRL---DEAEQIALKGGKKQLQKLEARVRELENELEAE 1829
Query: 264 ----------LRKQEAHLRKEKYSTDA-----------------KIKTFEDNLIEARKEV 296
+RK E +++ Y T+ K+K ++ EA ++
Sbjct: 1830 QKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1889
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+ SK+ + +L + + + +R + +++
Sbjct: 1890 NTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/218 (20%), Positives = 100/218 (45%), Gaps = 4/218 (1%)
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
+R V E+ K QEFE + V +Q L +R + ++ ++ L+KK +
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435
Query: 219 SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
+ E++DTK ++ ++ +N LE++ ++ + + + ++ + Q L++EK
Sbjct: 1436 TAELQDTKLHLEGQQVRNH----ELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDML 1491
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
A+ + + L E ++ K +L +L + ++ + + + V+K+L++L+
Sbjct: 1492 LAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV 1551
Query: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE 376
K +QA IQ L+ + + + H+ E
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Score = 47.4 bits (111), Expect = 2e-05
Identities = 39/191 (20%), Positives = 88/191 (46%), Gaps = 11/191 (5%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
++REK A+ + + L+ KD I F Q+ L+ E+ D+ ++ + A ++K+
Sbjct: 1484 LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQ 1543
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ 267
DLE K KD+ +E+ + +Q E+ + +E + S +++ +
Sbjct: 1544 LRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHS----------KEMESR 1593
Query: 268 EAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI-TL 326
+ + + + S K+K E L E ++ + + L +L+ ++ ++D +
Sbjct: 1594 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1653
Query: 327 VRKELQELQNL 337
+RK+L+ + L
Sbjct: 1654 LRKDLKRTKAL 1664
Score = 47.4 bits (111), Expect = 2e-05
Identities = 45/193 (23%), Positives = 92/193 (47%), Gaps = 21/193 (10%)
Query: 105 LEEELSSLKEELALCQ----ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
LEE+LS L+ E Q D+E + L K+ + ++ ++ + + + Q EA
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 161 KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE------KK 214
K Q K+Q + + L+Q + D K V + A +R+ + LE K+
Sbjct: 1790 K-----QELQEKLQALQSQVEFLEQSMVD----KSLVSRQEAKIRELETRLEFERTQVKR 1840
Query: 215 FKDKSQEIKDTKECVQNKEEQNRLVIKNLE-EENKKLSTRCTDLLNDLEKLRKQEAHLRK 273
+ + +K+ E + + +Q R+ +N E E+NK+L + D ++ +L ++EA +
Sbjct: 1841 LESLASRLKENMEKLTEERDQ-RIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASR 1899
Query: 274 EKYSTDAKIKTFE 286
+K+ + +++ E
Sbjct: 1900 KKHELEMDLESLE 1912
Score = 35.8 bits (81), Expect = 0.068
Identities = 38/171 (22%), Positives = 76/171 (44%), Gaps = 10/171 (5%)
Query: 156 EAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE--K 213
E +D + L + A + + R+ K++I DL R + ++N K D K
Sbjct: 1182 EQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCV---QKNIKKNKGVKDWPWWK 1238
Query: 214 KFKDKSQ--EIKDTKECVQNKEE---QNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQE 268
F E++ ++E ++NK+E Q R ++ E+E +L L + + +L +
Sbjct: 1239 LFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL 1298
Query: 269 AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
R S + + A KE++ Q++Y+AL Q+ + E+++
Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVME 1349
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/218 (20%), Positives = 100/218 (45%), Gaps = 4/218 (1%)
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
+R V E+ K QEFE + V +Q L +R + ++ ++ L+KK +
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRL 1435
Query: 219 SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
+ E++DTK ++ ++ +N LE++ ++ + + + ++ + Q L++EK
Sbjct: 1436 TAELQDTKLHLEGQQVRNH----ELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDML 1491
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
A+ + + L E ++ K +L +L + ++ + + + V+K+L++L+
Sbjct: 1492 LAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV 1551
Query: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE 376
K +QA IQ L+ + + + H+ E
Sbjct: 1552 KDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Score = 48.5 bits (114), Expect = 1e-05
Identities = 52/263 (19%), Positives = 122/263 (46%), Gaps = 26/263 (9%)
Query: 105 LEEELSSLKEELALCQ----ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
LEE+LS L+ E Q D+E + L K+ + ++ ++ + + + Q EA
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 161 KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE------KK 214
K Q K+Q + + L+Q + D K V + A +R+ + LE K+
Sbjct: 1790 K-----QELQEKLQALQSQVEFLEQSMVD----KSLVSRQEAKIRELETRLEFERTQVKR 1840
Query: 215 FKDKSQEIKDTKECVQNKEEQNRLVIKNLE-EENKKLSTRCTDLLNDLEKLRKQEAHLRK 273
+ + +K+ E + + +Q R+ +N E E+NK+L + D ++ +L ++EA +
Sbjct: 1841 LESLASRLKENMEKLTEERDQ-RIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASR 1899
Query: 274 EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQE 333
+K+ + +++ E + +++++ + L + ++ ++ D + L+ LQ+
Sbjct: 1900 KKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDE----MESDENEDLI-NSLQD 1954
Query: 334 LQNLYKQNSTHTAQQAELIQQLQ 356
+ Y++ +++ +L+
Sbjct: 1955 MVTKYQKRKNKLEGDSDVDSELE 1977
Score = 47.4 bits (111), Expect = 2e-05
Identities = 39/191 (20%), Positives = 88/191 (46%), Gaps = 11/191 (5%)
Query: 148 VEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKE 207
++REK A+ + + L+ KD I F Q+ L+ E+ D+ ++ + A ++K+
Sbjct: 1484 LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQ 1543
Query: 208 FSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ 267
DLE K KD+ +E+ + +Q E+ + +E + S +++ +
Sbjct: 1544 LRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHS----------KEMESR 1593
Query: 268 EAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI-TL 326
+ + + + S K+K E L E ++ + + L +L+ ++ ++D +
Sbjct: 1594 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1653
Query: 327 VRKELQELQNL 337
+RK+L+ + L
Sbjct: 1654 LRKDLKRTKAL 1664
Score = 35.8 bits (81), Expect = 0.068
Identities = 38/171 (22%), Positives = 76/171 (44%), Gaps = 10/171 (5%)
Query: 156 EAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE--K 213
E +D + L + A + + R+ K++I DL R + ++N K D K
Sbjct: 1182 EQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCV---QKNIKKNKGVKDWPWWK 1238
Query: 214 KFKDKSQ--EIKDTKECVQNKEE---QNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQE 268
F E++ ++E ++NK+E Q R ++ E+E +L L + + +L +
Sbjct: 1239 LFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL 1298
Query: 269 AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
R S + + A KE++ Q++Y+AL Q+ + E+++
Sbjct: 1299 TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVME 1349
>gi|45505178 cancer antigen 1 [Homo sapiens]
Length = 641
Score = 60.5 bits (145), Expect = 3e-09
Identities = 49/196 (25%), Positives = 101/196 (51%), Gaps = 5/196 (2%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKV 162
Q LEE L++ ++ L + DKE + +K+++ N Q + ++K KS ++ ++
Sbjct: 247 QNLEEVLANTQKHLQESRNDKEMLQLQFKKIKA-NYVCLQERYMTEMQQKNKSVSQYLEM 305
Query: 163 LEILQVKDAKIQEFEQRESVLKQEIN---DLVKR-KIAVDEENAFLRKEFSDLEKKFKDK 218
+ L K+ +++ +Q + L++ DL+KR K A ++E L++EF LEK+ ++
Sbjct: 306 DKTLSKKEEEVERLQQLKKELEKATASALDLLKREKEAQEQEFLSLQEEFQKLEKENLEE 365
Query: 219 SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
Q++K E + + + + +N +N KL + ++ N+ KL++Q A ++ Y
Sbjct: 366 RQKLKSRLEKLLTQVRNLQFMSENERTKNIKLQQQINEVKNENAKLKQQVARSEEQNYVP 425
Query: 279 DAKIKTFEDNLIEARK 294
+ +D L E K
Sbjct: 426 KFETAQLKDQLEEVLK 441
Score = 41.6 bits (96), Expect = 0.001
Identities = 49/237 (20%), Positives = 111/237 (46%), Gaps = 20/237 (8%)
Query: 150 REKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFS 209
+E Q S K ++ LQ+K K Q F + LK+ + +L++ K + E +K
Sbjct: 188 QELQCSNLYLEKRVKELQMKITKQQVFIDVINKLKENVEELIEDKYKIILEKNDTKKTLQ 247
Query: 210 DLEKKFKDKS---QEIKDTKECVQ---NKEEQNRLVIK-----NLEEENKKLSTRCTDLL 258
+LE+ + QE ++ KE +Q K + N + ++ ++++NK +S + ++
Sbjct: 248 NLEEVLANTQKHLQESRNDKEMLQLQFKKIKANYVCLQERYMTEMQQKNKSVS-QYLEMD 306
Query: 259 NDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
L K ++ L++ K + + D L ++E E + ++ +L + + E +
Sbjct: 307 KTLSKKEEEVERLQQLKKELEKATASALDLL---KREKEAQEQEFLSLQEEFQKLEKENL 363
Query: 319 QKDMDI-TLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDT----QKVLRNQE 370
++ + + + K L +++NL + + +L QQ+ + + Q+V R++E
Sbjct: 364 EERQKLKSRLEKLLTQVRNLQFMSENERTKNIKLQQQINEVKNENAKLKQQVARSEE 420
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 60.1 bits (144), Expect = 3e-09
Identities = 71/308 (23%), Positives = 136/308 (44%), Gaps = 41/308 (13%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQ----VVSLVV 148
S+EEA +E++L KEE + + V + K+ + + DL Q + L
Sbjct: 704 SIEEAKSVAMCEMEKKL---KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTG 760
Query: 149 EREKQKSEAKDRKVL-------EILQVKDAKIQEFEQR-----ESVLKQEINDLVKRKIA 196
+E+ + E K+ + +L + K Q FE E +KQEIN L++ K
Sbjct: 761 NKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRL 820
Query: 197 VDEENAFLRKEFSDLEKKFKDKSQEIK-----------DTKECVQNKEEQNRLVIKNLEE 245
++ E A L K++ E + ++ +++ KE + EE+NR +K ++E
Sbjct: 821 LEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQE 880
Query: 246 ENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+ T T L DL + + + L + T E +R E++ +
Sbjct: 881 LQNEKETLATQL--DLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTV 938
Query: 306 LSLQLSNKQTELIQKDMDITLVRKELQEL-QNLYKQNSTHTAQQAELIQQLQVL---NMD 361
L+ +N ++ KD++I +R+E +EL + + K + ++ E I L+ N++
Sbjct: 939 SRLEEAN---SMLTKDIEI--LRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNIN 993
Query: 362 TQKVLRNQ 369
T++ L+ Q
Sbjct: 994 TERTLKTQ 1001
Score = 52.0 bits (123), Expect = 9e-07
Identities = 58/266 (21%), Positives = 122/266 (45%), Gaps = 26/266 (9%)
Query: 104 LLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVL 163
L + ++ LKEE+ + ++E +L K ++ N T L + K +SE R +L
Sbjct: 855 LYKTQVKELKEEIE--EKNRE---NLKKIQELQNEKETLATQLDLAETKAESEQLARGLL 909
Query: 164 EILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIK 223
E + QE ++ S +QEI D ++E N+ L K+ L ++ ++ ++++K
Sbjct: 910 EEQYFE--LTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMK 967
Query: 224 DTKECVQNKEEQNRLVIKNLEEEN----KKLSTRCTDLLNDL---------------EKL 264
+E + ++E+ +K E+N + L T+ + L ++ + L
Sbjct: 968 KAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDL 1027
Query: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI 324
RK+E RK + + + + F +++ +KE+ Q++ + Q +L K+ DI
Sbjct: 1028 RKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDI 1087
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAE 350
+R +L +L + S +A + +
Sbjct: 1088 EQLRAKLLDLSDSTSVASFPSADETD 1113
Score = 42.4 bits (98), Expect = 7e-04
Identities = 67/334 (20%), Positives = 149/334 (44%), Gaps = 55/334 (16%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQA-----------DKEFVWSLWKRLQVTNPDLT 141
S+ + R ++LE S ++ QA D E + L R+ ++
Sbjct: 580 SLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVK 639
Query: 142 QVVSLVVEREKQKSEAKD-----RKVLEILQVK-DAKIQEFEQRESVLKQEINDLVKRKI 195
+ + + E ++ EA+D K L++ + K++ +QR L+QE+N+ K
Sbjct: 640 HLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQR---LEQEVNEHKVTKA 696
Query: 196 AVDEENAFLRKEFS----DLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKL- 250
+ +++ + + S ++EKK K++ + + + V E+Q ++ +L++ +KL
Sbjct: 697 RLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLE 756
Query: 251 -----STRCTDLLNDLEKLRKQEAH--------LRKEKYSTD------AKIKTFEDNLIE 291
R D + +L +QE++ L+ + + D ++K + L+E
Sbjct: 757 HLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLE 816
Query: 292 ARK--EVEVSQ--SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQ 347
A++ E E++Q +Y Q+ Q +L + TL + +++EL+ ++ + +
Sbjct: 817 AKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK 876
Query: 348 QAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQ 381
+ IQ+LQ + ++ L Q D+ ++ S Q
Sbjct: 877 K---IQELQ----NEKETLATQLDLAETKAESEQ 903
Score = 39.3 bits (90), Expect = 0.006
Identities = 53/244 (21%), Positives = 99/244 (40%), Gaps = 32/244 (13%)
Query: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAK-------- 172
ADK SL K + L + L E E QK + K+ +I++ D +
Sbjct: 420 ADKSLQESLQKTIYKLEEQLHNEMQLKDEME-QKCRTSNIKLDKIMKELDEEGNQRRNLE 478
Query: 173 --IQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQ 230
+ + E+ + +L+ IN+ ++ +E+ + E S L KD+ +++K + Q
Sbjct: 479 STVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTL----KDQLEDLKKVSQNSQ 534
Query: 231 NKEEQNRLVIKNLEEEN-------------KKLSTRCTDLLNDLEKLRK--QEAH--LRK 273
E+ + K LEE N +K T + ++ LE L + QE + L
Sbjct: 535 LANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILEN 594
Query: 274 EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQE 333
K TD + L R++ L ++++ Q E+ ++ V E +E
Sbjct: 595 SKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKE 654
Query: 334 LQNL 337
Q++
Sbjct: 655 AQDM 658
Score = 38.9 bits (89), Expect = 0.008
Identities = 41/208 (19%), Positives = 87/208 (41%), Gaps = 14/208 (6%)
Query: 151 EKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRK-IAVDEENAFLRKEFS 209
+ + S D+ + E LQ K++E E LK E+ + I +D+ L +E
Sbjct: 413 DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEE-G 471
Query: 210 DLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK--Q 267
+ + + +I+ K +Q++ + + + E+ + + + L + LE L+K Q
Sbjct: 472 NQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQ 531
Query: 268 EAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLV 327
+ L EK S K ++L+ + V +L TE+ + + +
Sbjct: 532 NSQLANEKLSQLQKQLEEANDLLRTESDTAV----------RLRKSHTEMSKSISQLESL 581
Query: 328 RKELQELQNLYKQNSTHTAQQAELIQQL 355
+ELQE + + + + T + +Q +
Sbjct: 582 NRELQERNRILENSKSQTDKDYYQLQAI 609
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 60.1 bits (144), Expect = 3e-09
Identities = 80/344 (23%), Positives = 154/344 (44%), Gaps = 52/344 (15%)
Query: 87 RRLEGISVEEAMVTRTQLLEEELSSLKEE------------LALCQADKEFVWSLWKRLQ 134
RRLE EE + + ++E+L +L+ E + L + DKE V L + L
Sbjct: 2125 RRLE--QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE-VQQLQENLD 2181
Query: 135 VTNPDLT----QVVSLVVEREKQKSEAK--DRKVLEILQVKDAKIQEFEQRESVLKQEIN 188
T L + SL +R++ EAK +RK + +Q K+ +I+ E SVLK ++
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR 2241
Query: 189 DL------VKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIK--DTKECVQNKEEQNRLV- 239
+ +K I+ E + + + + E + + K + + KE + EE L
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYH 2301
Query: 240 -----IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARK 294
+ LE E K L + TDL N LEK ++Q+ +L +A I+ + + +
Sbjct: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361
Query: 295 EVEVSQSKYNALSLQLSNKQTELI------QKDMDITLVR------KELQELQNLYKQ-- 340
+++ S+ + L +++ K+ ++I ++ + + + KE++EL+NL Q
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421
Query: 341 --NSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
N + + + + L M+T K ++ + A+ S+ K
Sbjct: 2422 EENIVLEEENKKAVDKTNQL-METLKTIKKENIQQKAQLDSFVK 2464
Score = 56.2 bits (134), Expect = 5e-08
Identities = 57/297 (19%), Positives = 136/297 (45%), Gaps = 20/297 (6%)
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNP----DLTQVVSLVVEREKQKSEA 157
+Q LE E ++L +++ + + + ++ + N +L++V L E++K +
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL 1922
Query: 158 KDRKVLEILQVKDA------KIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDL 211
++R + ++ ++ + + + + + +L+ E+ +L K ++EE L KE + +
Sbjct: 1923 EERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV 1982
Query: 212 EKKF-KDKSQEIKDTKECVQNKEEQNRL--VIKNLEEENKKLSTRCTDLLNDLEKLRKQE 268
E + K+ ++I+ ++ NK L ++K ++E K+L C + L +
Sbjct: 1983 ESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTV 2042
Query: 269 AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVR 328
L + + ++ ++NL +A + + +Q++ + + L + Q+E + D ++
Sbjct: 2043 KALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLK 2102
Query: 329 KELQELQNLYK-------QNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESI 378
KELQ + K ++ +QAE + NM + +E VH E+I
Sbjct: 2103 KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159
Score = 48.1 bits (113), Expect = 1e-05
Identities = 62/273 (22%), Positives = 127/273 (46%), Gaps = 28/273 (10%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
++ A+++R + L+E SL+EEL+L + E + L V S V + K+
Sbjct: 1485 LQAALISRKEALKEN-KSLQEELSLARGTIERL----------TKSLADVESQVSAQNKE 1533
Query: 154 KSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR-KIAVD---EENAFLRKEFS 209
K R L +LQ + K+ R + Q ++ + K+A++ E+ L KE
Sbjct: 1534 KDTVLGR--LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591
Query: 210 DLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEA 269
L KS +I ++ E Q K ++ + + L + + +S + + +E +R+++
Sbjct: 1592 SL------KSSKIAESTEW-QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ 1644
Query: 270 HLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK 329
L + ST+A K E L EA +E+E + K + +KQ ++++ + + +R
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA---KSKQQKILELEEENDRLRA 1701
Query: 330 ELQELQNLYKQ-NSTHTAQQAELIQQLQVLNMD 361
E+ + K+ T + A + ++L+ + M+
Sbjct: 1702 EVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
Score = 46.2 bits (108), Expect = 5e-05
Identities = 67/323 (20%), Positives = 130/323 (40%), Gaps = 43/323 (13%)
Query: 92 ISVEEAMVTRTQLL----EEELSSLKEELALCQADK-----EFVWSLWKRLQVTNPDLTQ 142
+ V+E V R L ++ ++ L+EEL Q + E L K L+ + D
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG- 2692
Query: 143 VVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENA 202
++ E + +E + ++ L + K+ + L +I + ++
Sbjct: 2693 ----IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748
Query: 203 FLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLV--------------IKNLEEENK 248
+E +L++K+ +E+ KE E++ L+ + +LE+ N+
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808
Query: 249 KL----------STRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEV 298
+L S++ D N ++ K A L+ E+ +++ F + E K+
Sbjct: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS--EEGKQRSA 2866
Query: 299 SQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVL 358
+Q + +Q K +Q D D L KEL+ LQ Y Q + + L QLQ
Sbjct: 2867 AQPSTSPAEVQSLKKAMSSLQNDRDRLL--KELKNLQQQYLQINQEITELHPLKAQLQEY 2924
Query: 359 NMDTQKVLRNQEDVHTAESISYQ 381
T+ QE++ E++S+Q
Sbjct: 2925 QDKTKAFQIMQEELR-QENLSWQ 2946
Score = 45.1 bits (105), Expect = 1e-04
Identities = 56/298 (18%), Positives = 128/298 (42%), Gaps = 20/298 (6%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQK 154
++ ++ R LL+EE L E+ + + + S + L++ LT+ +V K+
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV---KEI 1590
Query: 155 SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
K K+ E + ++ K +E ++ +L Q ++ + +R+E +L K
Sbjct: 1591 ESLKSSKIAESTEWQE-KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649
Query: 215 FKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
+ K+T++ +Q E++ +EE +K+ + +L ++ LR E
Sbjct: 1650 LRSTEANKKETEKQLQEAEQE-------MEEMKEKMRKFAKSKQQKILELEEENDRLRAE 1702
Query: 275 KYSTDAKIKTFEDNLIEA----RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE 330
+ K + L+ + ++E+E + +Y LS + + +E ++ ++ +
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Query: 331 LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKVCFYSV 388
++ N+ KQ + ++ + Q V TQ + E+ + S+S + C SV
Sbjct: 1763 IE--GNVSKQANLEATEKHD--NQTNVTEEGTQSIPGETEE-QDSLSMSTRPTCSESV 1815
Score = 43.9 bits (102), Expect = 3e-04
Identities = 55/291 (18%), Positives = 121/291 (41%), Gaps = 33/291 (11%)
Query: 99 VTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK 158
V + Q E S EE++L A E L+ T D + +S V + + +
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVE--------LKSTKQDGDKSLSAVPDIGQCHQDEL 686
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
+R +IL+++ F + + + ++ +++ K +++ +K + F
Sbjct: 687 ERLKSQILELE----LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742
Query: 219 SQE-------IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
S+E +K+ + + + +L + E E ++ + +D L +Q L
Sbjct: 743 SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSL 801
Query: 272 RKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
E S D KI+ ++ L + + + + +L QL NK++E+++ + + ++
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 332 QELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
+EL Q ++L++ MD Q +L + DV T + +K
Sbjct: 862 EELSQALSQ------------KELEITKMD-QLLLEKKRDVETLQQTIEEK 899
Score = 43.5 bits (101), Expect = 3e-04
Identities = 65/314 (20%), Positives = 138/314 (43%), Gaps = 24/314 (7%)
Query: 90 EGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVE 149
+G+ +E ++ T + E SL+++L Q + + L+ P L ++ L+ +
Sbjct: 1349 QGLEIE-SLKTVSHEAEVHAESLQQKLESSQLQIAGL----EHLRELQPKLDELQKLISK 1403
Query: 150 REKQKSEAKDRKVLEILQVKDA---KIQ-EFEQRESVLKQEINDLVKRKIAVDEENAFLR 205
+E+ S + L K+A KIQ E ++E ++K L + DE L+
Sbjct: 1404 KEEDVSYLSGQ-----LSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 206 KEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLR 265
E ++++K ++ +E + K+ +Q K + + K +ENK L + +E+L
Sbjct: 1459 VELCEMKQKPEEIGEESR-AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
Query: 266 KQEAHLR-------KEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
K A + KEK + ++ ++ + E++ S + +LS + + L
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQ-AELIQQLQVLNMDTQKVLRNQEDV-HTAE 376
D + KE++ L++ ST ++ EL ++ ++L + V E + H E
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE 1637
Query: 377 SISYQKVCFYSVIK 390
++ +K Y ++
Sbjct: 1638 AVRQEKQELYGKLR 1651
Score = 42.4 bits (98), Expect = 7e-04
Identities = 53/248 (21%), Positives = 109/248 (43%), Gaps = 24/248 (9%)
Query: 87 RRLEGISVE-EAMVTRTQLLEEELSSLKEE----LALCQADKEFVWSLWKRLQVTNPDLT 141
R+L+ + + ++ R LEEEL++LK+E + L + ++ V + + + +T
Sbjct: 993 RKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVT 1052
Query: 142 ---QVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFE----QRESVLKQEINDLVKRK 194
Q + + +++ + E + + + + L+ K A ++F+ Q L+ + N + +
Sbjct: 1053 SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQ 1112
Query: 195 IAVDEENAFLRKEF-SDLEKKFKDKSQEIKDT----KECVQNKE------EQNRLVI-KN 242
+ E A ++K S+ + D +K+T C + E E+ L + K
Sbjct: 1113 AEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKE 1172
Query: 243 LEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSK 302
E+ KKL T L+K +++E HLR+E ++ E KE E +
Sbjct: 1173 KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ 1232
Query: 303 YNALSLQL 310
L +Q+
Sbjct: 1233 LRQLQIQV 1240
Score = 42.0 bits (97), Expect = 0.001
Identities = 61/301 (20%), Positives = 136/301 (45%), Gaps = 24/301 (7%)
Query: 96 EAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKS 155
+++++ L EE+ LK ++ + + + + K TN S+ E E+Q S
Sbjct: 1743 QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
Query: 156 EAKDRKVLEILQVKDAK-IQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
+ + V AK ++ EIN+ +++ + E A L +E ++K
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEE----KQK 1858
Query: 215 FKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K+ SQ +++ K + ++ +K L+EE K++ + +L ++ K + +E
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 275 KYSTDAK-----------IKTFEDNLIEARKEVEVSQSKYNALS---LQLSNKQTELIQK 320
K + + I + ++ +A+ + E+ +S+ L +L ++ +L+++
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978
Query: 321 DMDI-TLVRKE-LQELQNLYKQ--NSTHTAQQAELIQQLQVLNMDTQK-VLRNQEDVHTA 375
+ + +RKE L+++Q K+ N +H + EL+++ Q QK +R QE +
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL 2038
Query: 376 E 376
E
Sbjct: 2039 E 2039
Score = 41.2 bits (95), Expect = 0.002
Identities = 69/346 (19%), Positives = 144/346 (41%), Gaps = 63/346 (18%)
Query: 79 LLSAPMGSRRLEGISVEEAMVTRTQL--LEEELSSLKEELALCQADKEFVWSLWKRLQ-- 134
LLS +R L S E ++L L+++L+ L L C+ K + + ++ +
Sbjct: 2289 LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD 2348
Query: 135 VTNPDLT--------QVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQ----EFEQRESV 182
+ N + Q + R ++ K++K++ +L K+ IQ E Q+
Sbjct: 2349 IQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK 2408
Query: 183 LKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDT-----KECVQNK----- 232
+E+ +L+ ++ +EEN L +E KK DK+ ++ +T KE +Q K
Sbjct: 2409 EIKELENLLSQE---EEENIVLEEE----NKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461
Query: 233 ----------------------EEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAH 270
EE++ +I ++ ++ + L ++ LR
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521
Query: 271 LRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ----LSNKQTELIQKDMDITL 326
L E DA++ + ++L + + Q + + LQ L NK +L +K +
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
Query: 327 VRKELQELQNLYKQNSTHTAQQAELIQQLQV-LNMDTQKVLRNQED 371
++L+ N ++ +++ I+ L+V ++ T++V QE+
Sbjct: 2582 ANEDLRRSFNALQEEKQDLSKE---IESLKVSISQLTRQVTALQEE 2624
Score = 39.7 bits (91), Expect = 0.005
Identities = 50/261 (19%), Positives = 120/261 (45%), Gaps = 46/261 (17%)
Query: 145 SLVVEREKQKSEAKDRKVLEIL--QVKDAKIQ----------EFEQR---ESVLKQEIND 189
+L ER++ S+ K+ ++ L QVK ++ ++E + +++L ++I+
Sbjct: 741 ALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS 800
Query: 190 LVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKK 249
L + D + L+ E D++ +F ++S I+ + +QNKE + + E +
Sbjct: 801 LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE----VLEGAERVRH 856
Query: 250 LSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ-------SK 302
+S++ +L L + + +I + L+E +++VE Q +
Sbjct: 857 ISSKVEELSQALSQ--------------KELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902
Query: 303 YNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDT 362
+S ++ K +L ++ + + K L+E NL + A++A+ +Q++ N +
Sbjct: 903 VTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR-----AEEAKK-EQVEEDNEVS 956
Query: 363 QKVLRNQEDVHTAESISYQKV 383
+ +N +++ A IS +++
Sbjct: 957 SGLKQNYDEMSPAGQISKEEL 977
Score = 38.9 bits (89), Expect = 0.008
Identities = 52/261 (19%), Positives = 104/261 (39%), Gaps = 34/261 (13%)
Query: 108 ELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR-KVLEIL 166
E+ SLK+ ++ Q D++ + K LQ + Q ++ + + Q E +D+ K +I+
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIM 2934
Query: 167 QVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEF----SDLEKKFKDKSQEI 222
Q +E Q + E++ L K + + +++++ SD +++ I
Sbjct: 2935 Q------EELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988
Query: 223 KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKI 282
++ + + + E +L+ + E LR Q KE + + +I
Sbjct: 2989 RELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI 3048
Query: 283 KTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNS 342
+ N + +E N LS+QL + + L+E Q Y
Sbjct: 3049 QQLNSNFSQLLEEK-------NTLSIQLCDTS--------------QSLRENQQHYGDLL 3087
Query: 343 THTAQQAELIQQLQV--LNMD 361
H A + +Q+LQ LN+D
Sbjct: 3088 NHCAVLEKQVQELQAGPLNID 3108
Score = 38.5 bits (88), Expect = 0.011
Identities = 55/266 (20%), Positives = 117/266 (43%), Gaps = 46/266 (17%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQK 154
EE++V R Q+++ L++EL + + + ++++ + L V ERE+ K
Sbjct: 265 EESLVGRAQVVD----LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE--TEREESK 318
Query: 155 SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
+L+ + ++ E + L++E++ L+++ + A L +S LE+K
Sbjct: 319 I---------LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQK 369
Query: 215 FKDKSQE---------------------IKD-TKECVQNKEE---QNRLVIKNLEEENKK 249
K + +E +KD + +Q+K E Q+ I+ LE++ ++
Sbjct: 370 HKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQ 429
Query: 250 LSTRCTDLLNDLEKLRKQEAHLRK--EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNAL- 306
S + LN L + + A + Y+ + T E+N+ +K V +++ AL
Sbjct: 430 KSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT-EENIASLQKRVVELENEKGALL 488
Query: 307 --SLQLSNKQTELIQKDMDITLVRKE 330
S++L + E + ITL+ +
Sbjct: 489 LSSIELEELKAENEKLSSQITLLEAQ 514
Score = 36.6 bits (83), Expect = 0.040
Identities = 52/255 (20%), Positives = 109/255 (42%), Gaps = 34/255 (13%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ---KSEA 157
+ +LLE E+ +LK+ ++ + +K+ + + ++ +V + + + + +K+ KS A
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQL--VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 158 KDRKVL------EILQV---------------KDAKIQEFEQRES-----VLKQEINDLV 191
K+ + L E+ Q+ + K EF Q ES + K+ + V
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 192 KRKIAVDEENAFLRKEFSDLEKKF-KDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKL 250
+ + E A + D + + + + +K KE NKE + + E+ ++L
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127
Query: 251 STRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL 310
L + + ++++ LR+EK + I + L + KEV+ Q ++ QL
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187
Query: 311 S--NKQTELIQKDMD 323
+ K +Q D D
Sbjct: 2188 AAFTKSMSSLQDDRD 2202
Score = 29.6 bits (65), Expect = 4.9
Identities = 29/173 (16%), Positives = 69/173 (39%), Gaps = 22/173 (12%)
Query: 210 DLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEA 269
D++++ Q + + K+ ++ K+ Q + + L+EE K +
Sbjct: 49 DVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK---------------- 92
Query: 270 HLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRK 329
++K K AK+ + + E + + QLS +++M+I ++
Sbjct: 93 -IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 151
Query: 330 ELQELQNLY-----KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAES 377
+LQE + L + Q A+ +++ M Q++ +E + T ++
Sbjct: 152 KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQA 204
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 60.1 bits (144), Expect = 3e-09
Identities = 59/229 (25%), Positives = 108/229 (47%), Gaps = 23/229 (10%)
Query: 149 EREKQKSEAKD--RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ +K + L +AK +E E++ L +E NDL ++ V E L
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL---QLQVQSEADSLAD 903
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
E+ K+K Q KE + EE+ + + L + +KL C++L D++ L
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE-LTAKKRKLEDECSELKKDIDDLEL 962
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K NL E ++ + +K +K+ + +Q+ TL
Sbjct: 963 TLAKVEKEKHATENKVK----NLTEEMAGLDETIAKL--------SKEKKALQETHQQTL 1010
Query: 327 VRKELQELQ-NLYKQNSTHTAQQAE----LIQQLQVLNMDTQKVLRNQE 370
+ +E + N+ + T QQ + ++Q + L MD ++ R E
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1059
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/325 (20%), Positives = 142/325 (43%), Gaps = 42/325 (12%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVV 148
L+ E+ M T ++EE K+ELA +A ++ + L DL V
Sbjct: 843 LKSAETEKEMAT----MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEA 898
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKE 207
+ E ++ + +Q+ +AKI+E +R ++EIN +L +K +++E + L+K+
Sbjct: 899 DSLADAEERCEQLIKNKIQL-EAKIKEVTERAEE-EEEINAELTAKKRKLEDECSELKKD 956
Query: 208 FSDLE--------------KKFKDKSQEIKDTKECVQNK-------EEQNRLVIKNLE-E 245
DLE K K+ ++E+ E + +E ++ + +L+ E
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE 1016
Query: 246 ENK---------KLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEV 296
E+K KL + DL LE+ +K L + K + +K +++ ++ +
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELI 352
+ K ++SN +++ + ++K+++ELQ L ++ A +A+
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136
Query: 353 QQLQVLNMDTQKVLRNQEDVHTAES 377
+Q L+ + +++ E+ A S
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGATS 1161
Score = 51.2 bits (121), Expect = 2e-06
Identities = 43/221 (19%), Positives = 96/221 (43%), Gaps = 19/221 (8%)
Query: 171 AKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQ 230
A +++ E+ + +QE+ D +R + +N L LE D SQ + +E +Q
Sbjct: 1693 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEN---DVSQLQSEVEEVIQ 1749
Query: 231 NKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLI 290
+N EE+ KK T + +L+K + AHL + K + + +K + L
Sbjct: 1750 ES--------RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1801
Query: 291 EA--------RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNS 342
EA +K+++ +++ L ++ N+Q + + + ++EL +++
Sbjct: 1802 EAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1861
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKV 383
+ + +L+ +LQ ++ E+ A ++K+
Sbjct: 1862 KNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKL 1902
Score = 48.1 bits (113), Expect = 1e-05
Identities = 56/257 (21%), Positives = 113/257 (43%), Gaps = 31/257 (12%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVE--REKQKSEAKDR 160
++ E+EL E + L + + K+L+ D++Q+ S V E +E + +E K +
Sbjct: 1703 KIAEQELLDASERVQLLHTQNTSLINTKKKLE---NDVSQLQSEVEEVIQESRNAEEKAK 1759
Query: 161 KVL-------EILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEK 213
K + E L+ + E+ + L+Q + DL R +DE K +
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR---LDEAEQLALKGGKKQIQ 1816
Query: 214 KFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRK 273
K + + +E++ V+N++++N +K L + +++ +L E+ RK L+
Sbjct: 1817 KLEARVRELEGE---VENEQKRNAEAVKGLRKHERRVK----ELTYQTEEDRKNVLRLQD 1869
Query: 274 EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQE 333
AK+K+++ EA ++ + SK+ L Q EL + + + ++ +
Sbjct: 1870 LVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKL-------QHELEEAEERADIAESQVNK 1922
Query: 334 LQNLYKQNSTHTAQQAE 350
L+ K HT AE
Sbjct: 1923 LR--VKSREVHTKISAE 1937
Score = 47.8 bits (112), Expect = 2e-05
Identities = 46/200 (23%), Positives = 85/200 (42%), Gaps = 29/200 (14%)
Query: 206 KEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLR 265
+E + +KK + QE ++ E V K +LE+ ++L DL+ D+E+
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAK-------CASLEKTKQRLQNEVEDLMLDVERSN 1439
Query: 266 KQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL--------------- 310
A L K++ + D + ++ E + E+E SQ + +LS +L
Sbjct: 1440 AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLE 1499
Query: 311 ------SNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQ-QAELIQQLQVLNMDTQ 363
N Q E+ I K++ EL+ + KQ + QA L + L +
Sbjct: 1500 TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEG 1559
Query: 364 KVLRNQEDVHTAESISYQKV 383
K+LR Q +++ +S +K+
Sbjct: 1560 KILRIQLELNQVKSEVDRKI 1579
Score = 45.1 bits (105), Expect = 1e-04
Identities = 51/250 (20%), Positives = 108/250 (43%), Gaps = 23/250 (9%)
Query: 142 QVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR-------K 194
Q V + ++++ ++ +A+ ++ E ++ + A + E++ S L +E+ ++ +R
Sbjct: 1101 QAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160
Query: 195 IAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLV----IKNLEEENKKL 250
A E N EF L + ++ + + + ++ K + I NL+ +KL
Sbjct: 1161 SAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKL 1220
Query: 251 STRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL 310
++L + + L + K K + + ++ ED + E + + E Q N L+ Q
Sbjct: 1221 EKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQR 1280
Query: 311 SNKQTE-------LIQKDMDITLVRK----ELQELQNLYKQNSTHTAQQAELIQQLQVLN 359
+ QTE L +KD ++ + + Q+++ L Q T + L LQ
Sbjct: 1281 ARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSR 1340
Query: 360 MDTQKVLRNQ 369
D +LR Q
Sbjct: 1341 HDCD-LLREQ 1349
Score = 43.5 bits (101), Expect = 3e-04
Identities = 67/299 (22%), Positives = 140/299 (46%), Gaps = 52/299 (17%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R Q EE+ + + AL +A+ E + W+ T D Q +E K+K + +
Sbjct: 1347 REQYEEEQEGKAELQRALSKANSEV--AQWRTKYET--DAIQRTE-ELEEAKKKLAQRLQ 1401
Query: 161 KVLEILQVKDAKIQEFEQRESVLKQEINDL---VKRK----IAVDEENAFLRKEFSDLEK 213
+ E ++ +AK E+ + L+ E+ DL V+R A+D++ K S+ ++
Sbjct: 1402 EAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQ 1461
Query: 214 KFKDKSQEIKDTKE----------CVQNKEEQN-------RLVIKNLEEENKKLSTRCTD 256
K+++ E++ +++ V+N E++ R KNL++E L+ + +
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAE 1521
Query: 257 ---LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNK 313
+++LEK++KQ + +EK A ++ EA +E + K + L+L+
Sbjct: 1522 GGKQIHELEKIKKQ---VEQEKCEIQAALE-------EAEASLEHEEGKILRIQLELNQV 1571
Query: 314 QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQ--QAELIQQLQVLNMDTQKVLRNQE 370
++E+ +K + ++ +E+ L K+N T + Q+ L +++ N D +V + E
Sbjct: 1572 KSEVDRK------IAEKDEEIDQL-KRNHTRVVETMQSTLDAEIRSRN-DALRVKKKME 1622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,169,339
Number of Sequences: 37866
Number of extensions: 685742
Number of successful extensions: 11007
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 928
Number of HSP's that attempted gapping in prelim test: 6298
Number of HSP's gapped (non-prelim): 3470
length of query: 391
length of database: 18,247,518
effective HSP length: 104
effective length of query: 287
effective length of database: 14,309,454
effective search space: 4106813298
effective search space used: 4106813298
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.