Search of human proteins with 110815813

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110815813 ankyrin repeat and FYVE domain containing 1
isoform 1 [Homo sapiens]
         (1170 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...  2327   0.0  
gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform ...   897   0.0  
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        219   1e-56
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       208   3e-53
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        208   3e-53
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        208   3e-53
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       197   4e-50
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        197   4e-50
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        197   4e-50
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        197   4e-50
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        197   4e-50
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  166   1e-40
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   160   5e-39
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   152   1e-36
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   152   2e-36
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   140   7e-33
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   136   1e-31
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   129   2e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   124   4e-28
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    112   3e-24
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    111   4e-24
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...    99   2e-20
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    99   2e-20
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...    99   2e-20
gi|34304381 inversin isoform a [Homo sapiens]                          99   2e-20
gi|34304379 inversin isoform b [Homo sapiens]                          99   2e-20
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           97   9e-20
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...    97   9e-20
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                     97   9e-20
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     94   1e-18

>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
            [Homo sapiens]
          Length = 1170

 Score = 2327 bits (6031), Expect = 0.0
 Identities = 1170/1170 (100%), Positives = 1170/1170 (100%)

Query: 1    MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60
            MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD
Sbjct: 1    MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60

Query: 61   LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120
            LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW
Sbjct: 61   LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120

Query: 121  IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180
            IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
Sbjct: 121  IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180

Query: 181  TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240
            TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE
Sbjct: 181  TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240

Query: 241  MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300
            MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG
Sbjct: 241  MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300

Query: 301  DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360
            DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
Sbjct: 301  DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360

Query: 361  NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
            NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV
Sbjct: 361  NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420

Query: 421  NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN 480
            NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN
Sbjct: 421  NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN 480

Query: 481  GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS 540
            GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS
Sbjct: 481  GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS 540

Query: 541  VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600
            VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG
Sbjct: 541  VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600

Query: 601  MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660
            MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL
Sbjct: 601  MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660

Query: 661  QLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP 720
            QLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP
Sbjct: 661  QLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP 720

Query: 721  GPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAAS 780
            GPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAAS
Sbjct: 721  GPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAAS 780

Query: 781  WGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLT 840
            WGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLT
Sbjct: 781  WGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLT 840

Query: 841  PFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNS 900
            PFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNS
Sbjct: 841  PFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNS 900

Query: 901  RVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLL 960
            RVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLL
Sbjct: 901  RVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLL 960

Query: 961  ENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKE 1020
            ENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKE
Sbjct: 961  ENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKE 1020

Query: 1021 NAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVN 1080
            NAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVN
Sbjct: 1021 NAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVN 1080

Query: 1081 IFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCST 1140
            IFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCST
Sbjct: 1081 IFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGVTTRKHHCRHCGRLLCHKCST 1140

Query: 1141 KEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1170
            KEIPIIKFDLNKPVRVCNICFDVLTLGGVS
Sbjct: 1141 KEIPIIKFDLNKPVRVCNICFDVLTLGGVS 1170


>gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform 2
           [Homo sapiens]
          Length = 487

 Score =  897 bits (2319), Expect = 0.0
 Identities = 461/469 (98%), Positives = 461/469 (98%)

Query: 1   MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60
           MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD
Sbjct: 1   MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD 60

Query: 61  LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120
           LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW
Sbjct: 61  LYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRW 120

Query: 121 IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180
           IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
Sbjct: 121 IYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS 180

Query: 181 TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240
           TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE
Sbjct: 181 TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIE 240

Query: 241 MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300
           MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG
Sbjct: 241 MDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG 300

Query: 301 DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360
           DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
Sbjct: 301 DLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP 360

Query: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
           NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV
Sbjct: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420

Query: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAG 469
           NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATG     R   AG
Sbjct: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGKARASRRGDAG 469



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 54/166 (32%), Positives = 81/166 (48%), Gaps = 26/166 (15%)

Query: 686 DEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFL 745
           D  G+  L LAL+  LE IA+TLV H  D             +LLH+ I   +   A FL
Sbjct: 253 DHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGW----SLLHKGIQRGDLFAATFL 308

Query: 746 IRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWG-----------LEETVQCLLEFG 794
           I++G  VN+         G +E     TPLHL A +            + +  + LL+ G
Sbjct: 309 IKNGAFVNAATL------GAQE-----TPLHLVALYSSKKHSADVMSEMAQIAEALLQAG 357

Query: 795 ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLT 840
           AN N QD++GRTP+HV+I + +  +   L+    + L ++D +G T
Sbjct: 358 ANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGST 403



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 48/176 (27%), Positives = 79/176 (44%), Gaps = 19/176 (10%)

Query: 546 PLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIA 605
           PLH AI     DVV + L +  + L    N          D      L LAL   + +IA
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEA--------DHNGDLALDLALSRRLESIA 272

Query: 606 AQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLA-- 663
             L+   A ++     G +LLH  IQR D  +A FL+++ A +N +     ET L L   
Sbjct: 273 TTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVAL 332

Query: 664 ---------IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVR 710
                    + +++  + +A+   GA+ ++ D KG  PL +++    E + S L++
Sbjct: 333 YSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 71/252 (28%), Positives = 93/252 (36%), Gaps = 71/252 (28%)

Query: 362 MQDSKGRTPLHVSIMAGNE-YVFSQLLQC-KQLDLELK--DHEGSTALWLAVQHITVSSD 417
           M  SK   PLH +I    E  VF  L++   QL  +L   DH G  AL LA+        
Sbjct: 213 MIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRL---- 268

Query: 418 QSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFL 477
                               S A  L+   +  D  D + G  LL +    G+  AA FL
Sbjct: 269 -------------------ESIATTLVSHKADVDMVDKS-GWSLLHKGIQRGDLFAATFL 308

Query: 478 ATNGAHVNHRNKWG-ETPLHTACRHG-----------LANLTAELLQQGANPNLQTEEAL 525
             NGA VN       ETPLH    +            +A +   LLQ GANPN+Q  +  
Sbjct: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG- 367

Query: 526 PLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLK 585
                             +TPLH++I   +  V S +L+ K              D  LK
Sbjct: 368 ------------------RTPLHVSIMAGNEYVFSQLLQCKQ------------LDLELK 397

Query: 586 DSRDQTVLGLAL 597
           D    T L LA+
Sbjct: 398 DHEGSTALWLAV 409



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 41/159 (25%), Positives = 70/159 (44%), Gaps = 11/159 (6%)

Query: 910  PLHLAVQAGSEIIVRNLLLA-----GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGV 964
            PLH A++   E +V   L+        K+NE   +   AL LA  + L +I + L+ +  
Sbjct: 221  PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280

Query: 965  DFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQY-GKENAA 1023
            D   VD++G + LH  +  G L     L+        A     ++PLH++  Y  K+++A
Sbjct: 281  DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340

Query: 1024 AIFDLFLE-----CMPGYPLDKPDADGSTVLLLAYMKGN 1057
             +     +        G   +  D+ G T L ++ M GN
Sbjct: 341  DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGN 379



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 52/221 (23%), Positives = 79/221 (35%), Gaps = 59/221 (26%)

Query: 807 PIHVAISSQHGVIIQLLVSHPDIHL----NVRDRQGLTPFACAMTFKNNKSAEAILKRES 862
           P+H AI  +   ++ L +   D  L    N  D  G      A++ +    A  ++  ++
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280

Query: 863 GAAEQVDNKGRNFLHVAVQNSDIESVLFLIS----------------------------- 893
              + VD  G + LH  +Q  D+ +  FLI                              
Sbjct: 281 DV-DMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHS 339

Query: 894 --------------VHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKH 939
                         + A  N  +QD+   TPLH+++ AG+E +   LL       EL  H
Sbjct: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399

Query: 940 R-QTALHLAAQ-------QDLPTICSVLLENGVDFAAVDEN 972
              TAL LA Q       Q +     V + NG  F   DEN
Sbjct: 400 EGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSF---DEN 437


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  219 bits (558), Expect = 1e-56
 Identities = 212/821 (25%), Positives = 352/821 (42%), Gaps = 84/821 (10%)

Query: 272  ATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVA 331
            A   + +  D+++ +++G + LH   + G +   + L++  A V+AAT     T LH+ +
Sbjct: 57   ALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG-NTALHIAS 115

Query: 332  LYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQ 391
            L           +  A++ + L+  GAN N Q   G TPL+++    +  V   LL    
Sbjct: 116  L-----------AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD-NG 163

Query: 392  LDLELKDHEGSTALWLAVQH-----ITVSSDQSVNPFEDVPVVN-GTSFDENSFAARLIQ 445
                L   +G T L +A+Q      +++  +        +P ++     D+   AA L+Q
Sbjct: 164  ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223

Query: 446  RGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLAN 505
              ++ D  ++ +G   L  AA  GN   A  L    A V+   +   TPLH A + G AN
Sbjct: 224  NDNNADV-ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282

Query: 506  LTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQ 565
            +   LL +GA  + +T + L                   TPLH      H  VV ++L++
Sbjct: 283  MVKLLLDRGAKIDAKTRDGL-------------------TPLHCGARSGHEQVVEMLLDR 323

Query: 566  KANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ-LLGSGAAINDTMSDGQT 624
             A  L  T N               + L +A   G H    Q LL     ++D  +D  T
Sbjct: 324  AAPILSKTKN-------------GLSPLHMAT-QGDHLNCVQLLLQHNVPVDDVTNDYLT 369

Query: 625  LLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSV 684
             LH+A      K A  LL+ +A+ N ++  +G T L +A +     V++ +   GA +  
Sbjct: 370  ALHVAAHCGHYKVAKVLLDKKANPN-AKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428

Query: 685  PDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACF 744
              E G  P+ +A      +I S L+ HG              +T LH A          +
Sbjct: 429  VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG----ETALHMAARSGQAEVVRY 484

Query: 745  LIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEG 804
            L++ G  V            E +A+D QTPLH++A  G  + VQ LL+ GA+ NA    G
Sbjct: 485  LVQDGAQV------------EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 805  RTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGA 864
             TP+H++    H  +   L+ H    L++  ++G TP   A  +   + A  +L++ S +
Sbjct: 533  YTPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAKYGKLEVANLLLQK-SAS 590

Query: 865  AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVR 924
             +     G   LHVA    + +  L L+   A+ ++  ++    TPLH+A +     I  
Sbjct: 591  PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG--YTPLHIAAKKNQMDIAT 648

Query: 925  NLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 984
             LL  GA  N +T+    ++HLAAQ+    + S+LL    +    +++G   LHLA    
Sbjct: 649  TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQED 708

Query: 985  RLNNIRVLLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIF-----DLFLECMPGY-P 1037
            R+N   VL+ +   VDA+     G +PLH+   YG              +  +   GY P
Sbjct: 709  RVNVAEVLVNQGAHVDAQ--TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766

Query: 1038 LDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
            L +    G T ++   ++ NA+     V     LG+    G
Sbjct: 767  LHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 807



 Score =  199 bits (507), Expect = 1e-50
 Identities = 216/835 (25%), Positives = 326/835 (39%), Gaps = 159/835 (19%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG  AL LA       + + L+  +A+VD   K G + LH     G       L
Sbjct: 67   INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            + NGA VNA +     TPL++ A                ++ + LL  GA+ ++    G 
Sbjct: 127  VTNGANVNAQSQNGF-TPLYMAA-----------QENHLEVVKFLLDNGASQSLATEDGF 174

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428
            TPL V++  G++ V S LL+         D +G   L     HI    D           
Sbjct: 175  TPLAVALQQGHDQVVSLLLE--------NDTKGKVRL--PALHIAARKD----------- 213

Query: 429  VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                   +   AA L+Q  ++ D  ++ +G   L  AA  GN   A  L    A V+   
Sbjct: 214  -------DTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265

Query: 489  KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
            +   TPLH A + G AN+   LL +GA  + +T + L                   TPLH
Sbjct: 266  RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL-------------------TPLH 306

Query: 549  MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
                  H  VV ++L++ A  L  T N               + L +A   G H    QL
Sbjct: 307  CGARSGHEQVVEMLLDRAAPILSKTKN-------------GLSPLHMAT-QGDHLNCVQL 352

Query: 609  L-GSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
            L      ++D  +D  T LH+A      K A  LL+ +A+ N ++  +G T L +A +  
Sbjct: 353  LLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN-AKALNGFTPLHIACKKN 411

Query: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
               V++ +   GA +    E G  P+ +A      +I S L+ HG              +
Sbjct: 412  RIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG----E 467

Query: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
            T LH A          +L++ G  V            E +A+D QTPLH++A  G  + V
Sbjct: 468  TALHMAARSGQAEVVRYLVQDGAQV------------EAKAKDDQTPLHISARLGKADIV 515

Query: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSH------------PDIHLNVR- 834
            Q LL+ GA+ NA    G TP+H++    H  +   L+ H              +H+  + 
Sbjct: 516  QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575

Query: 835  -------------------DRQGLTPFACAMTFKNNKSAEAILKR--------------- 860
                                + GLTP   A  + N K A  +L +               
Sbjct: 576  GKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPL 635

Query: 861  ----------------ESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQ 903
                            E GA A  V  +G   +H+A Q   ++ V  L+  +ANVN  + 
Sbjct: 636  HIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN--LS 693

Query: 904  DASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENG 963
            + S LTPLHLA Q     +   L+  GA V+  TK   T LH+        I + LL++ 
Sbjct: 694  NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHS 753

Query: 964  VDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYG 1018
                A  +NG   LH A   G  + I VLL +         + G + L I  + G
Sbjct: 754  AKVNAKTKNGYTPLHQAAQQGHTHIINVLL-QNNASPNELTVNGNTALGIARRLG 807



 Score =  182 bits (463), Expect = 1e-45
 Identities = 172/655 (26%), Positives = 278/655 (42%), Gaps = 96/655 (14%)

Query: 441  ARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACR 500
            + L+QR ++ DA  T  GN  L  A+ AG       L TNGA+VN +++ G TPL+ A +
Sbjct: 91   SELLQREANVDAA-TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ 149

Query: 501  HGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVS 560
                 +   LL  GA+ +L TE+                     TPL +A+   H  VVS
Sbjct: 150  ENHLEVVKFLLDNGASQSLATEDGF-------------------TPLAVALQQGHDQVVS 190

Query: 561  VILEQKAN------ALH----------ATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTI 604
            ++LE          ALH          A   LQ   +  ++     T L +A   G   +
Sbjct: 191  LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250

Query: 605  AAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAI 664
            A  LL   AA++ T  +  T LH+A +R ++     LL+  A I+ ++T+DG T L    
Sbjct: 251  ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID-AKTRDGLTPLHCGA 309

Query: 665  RNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGG 724
            R+    VV+ +  R A +    + G  PL +A   +  +                     
Sbjct: 310  RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN--------------------- 348

Query: 725  CLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLE 784
            C+Q LL     ++N P                        ++   D  T LH+AA  G  
Sbjct: 349  CVQLLL-----QHNVPV-----------------------DDVTNDYLTALHVAAHCGHY 380

Query: 785  ETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFAC 844
            +  + LL+  AN NA+   G TP+H+A       +++LL+ H    +      GLTP   
Sbjct: 381  KVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHV 439

Query: 845  AMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQD 904
            A  F  + +  + L     +    + +G   LH+A ++   E V +L+   A V ++ +D
Sbjct: 440  A-AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498

Query: 905  ASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGV 964
                TPLH++ + G   IV+ LL  GA  N  T    T LHL+A++    + + LL++G 
Sbjct: 499  DQ--TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556

Query: 965  DFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAA 1024
              +   + G   LH+A  +G+L  +  LL + +   +A    G +PLH+   Y  +  A 
Sbjct: 557  SLSITTKKGFTPLHVAAKYGKL-EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVAL 615

Query: 1025 IFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
               L L+   G        +G T L +A  K   ++   ++  GA       QG+
Sbjct: 616  ---LLLD--QGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI 665


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  208 bits (529), Expect = 3e-53
 Identities = 215/837 (25%), Positives = 348/837 (41%), Gaps = 106/837 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG  AL LA       +   L+   + VD   K G + LH     G       L
Sbjct: 36   INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +K GA +NA +     TPL++ A    +++  DV+       + LL+ GAN +     G 
Sbjct: 96   VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 143

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428
            TPL V++  G+    + LL+         D +G     L   HI                
Sbjct: 144  TPLAVALQQGHNQAVAILLE--------NDTKGKVR--LPALHIAARK------------ 181

Query: 429  VNGTSFDENSFAARLIQRGSHTDAPD-------TATGNCLLQRAAGAGNEAAALFLATNG 481
                  D+   AA L+Q   + D          T +G   L  AA  GN   A  L   G
Sbjct: 182  ------DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235

Query: 482  AHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSV 541
            A V+   + G TPLH A + G  N+   LL +G   + +T + L                
Sbjct: 236  AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL---------------- 279

Query: 542  HLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601
               TPLH A    H  VV ++LE+ A  L  T N               + L +A     
Sbjct: 280  ---TPLHCAARSGHDQVVELLLERGAPLLARTKN-------------GLSPLHMAAQGDH 323

Query: 602  HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661
                  LL   A ++D   D  T LH+A      +    LL+ +A+ N +R  +G T L 
Sbjct: 324  VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN-ARALNGFTPLH 382

Query: 662  LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721
            +A +     V++ +   GA +    E G  P+ +A      +I   L+++G         
Sbjct: 383  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442

Query: 722  PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASW 781
                 +T LH A           L+R+G  V++             AR+ QTPLH+A+  
Sbjct: 443  G----ETALHMAARAGQVEVVRCLLRNGALVDA------------RAREEQTPLHIASRL 486

Query: 782  GLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP 841
            G  E VQ LL+  A+ +A    G TP+H++       +  +L+     H ++  ++G TP
Sbjct: 487  GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTP 545

Query: 842  FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
               A  + +   A+ +L+R + AA+     G   LHVA    + +  L L+   A+ ++ 
Sbjct: 546  LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 604

Query: 902  VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961
             ++    TPLH+A +     I   LL  GA+ N +TK   T LHLA+Q+    + ++LL+
Sbjct: 605  AKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662

Query: 962  NGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKEN 1021
             G +     ++G  +LHLA    ++ N+  +LT+   D +A    G +PL +   YG  N
Sbjct: 663  KGANIHMSTKSGLTSLHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYG--N 719

Query: 1022 AAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
               +  L  +   G  ++    +G T L  A  +G+ ++   +++ GA+       G
Sbjct: 720  VKMVNFLLKQ---GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773



 Score =  171 bits (434), Expect = 3e-42
 Identities = 187/662 (28%), Positives = 280/662 (42%), Gaps = 71/662 (10%)

Query: 459  NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPN 518
            N    RAA AGN    +     G  +N  N+ G   LH A + G   L  ELL +G++ +
Sbjct: 11   NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70

Query: 519  L----------------QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562
                             Q E    L KE A++   A S +  TPL+MA   NH DVV  +
Sbjct: 71   SATKKGNTALHIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 563  LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG 622
            LE  AN   AT +               T L +AL  G +   A LL      NDT    
Sbjct: 129  LENGANQSTATED-------------GFTPLAVALQQGHNQAVAILLE-----NDTKGKV 170

Query: 623  Q-TLLHMAIQRQDSKSALFLL--EHQADIN----VSR-TQDGETALQLAIRNQLPLVVDA 674
            +   LH+A ++ D+KSA  LL  +H AD+     V+R T+ G T L +A       V   
Sbjct: 171  RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230

Query: 675  ICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG--CDA-TCWGPGPGGCLQTLLH 731
            +  RGA +      G  PL +A      ++   L+  G   DA T  G  P  C     H
Sbjct: 231  LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290

Query: 732  RAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEAR--------------DGQTPLHL 777
              + E        L+    +  SP    A G+  E  +              D  T LH+
Sbjct: 291  DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350

Query: 778  AASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQ 837
            AA  G     + LL+  AN NA+   G TP+H+A       +++LLV +    +      
Sbjct: 351  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASIQAITES 409

Query: 838  GLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHAN 897
            GLTP   A  F  + +   +L +   + +  + +G   LH+A +   +E V  L+   A 
Sbjct: 410  GLTPIHVA-AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468

Query: 898  VNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICS 957
            V++R ++  + TPLH+A + G   IV+ LL   A  +  T +  T LH++A++    + S
Sbjct: 469  VDARARE--EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 526

Query: 958  VLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQY 1017
            VLLE G   +   + G   LH+A  +G L ++  LL +    A++    G +PLH+   Y
Sbjct: 527  VLLEAGAAHSLATKKGFTPLHVAAKYGSL-DVAKLLLQRRAAADSAGKNGLTPLHVAAHY 585

Query: 1018 GKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQ 1077
              +  A    L LE   G        +G T L +A  K    +   ++  GA   +   Q
Sbjct: 586  DNQKVAL---LLLE--KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ 640

Query: 1078 GV 1079
            GV
Sbjct: 641  GV 642



 Score =  150 bits (380), Expect = 5e-36
 Identities = 187/667 (28%), Positives = 274/667 (41%), Gaps = 115/667 (17%)

Query: 242 DSQLPGKLNEADHNGDLALDLALSRRLES---------------IATTLVSHKADVDMVD 286
           D++    L + DHN D+   + ++R  ES               +AT L++  A VD   
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 242

Query: 287 KSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEM 346
           ++G + LH   +RG+      L+  G  ++A T     TPLH  A            S  
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAA-----------RSGH 290

Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK-QLDLELKDHEGSTAL 405
            Q+ E LL+ GA    +   G +PLH++    +      LLQ K  +D    D+   TAL
Sbjct: 291 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY--LTAL 348

Query: 406 WLAVQ--HITVSS---DQSVNPFEDVPVVNGTSFDENSFAAR---------LIQRGSHTD 451
            +A    H  V+    D+  NP  +   +NG  F     A +         L++ G+   
Sbjct: 349 HVAAHCGHYRVTKLLLDKRANP--NARALNG--FTPLHIACKKNRIKVMELLVKYGASIQ 404

Query: 452 APDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELL 511
           A  T +G   +  AA  G+    L L  NGA  +  N  GET LH A R G   +   LL
Sbjct: 405 A-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 463

Query: 512 QQGANPNLQTEEALPLPKEAASLTSLADSVHL---------------QTPLHMAIAYNHP 556
           + GA  + +  E    P   AS     + V L                TPLH++      
Sbjct: 464 RNGALVDARAREE-QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522

Query: 557 DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
           DV SV+LE  A A H           SL   +  T L +A   G   +A  LL   AA +
Sbjct: 523 DVASVLLE--AGAAH-----------SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569

Query: 617 DTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAIC 676
               +G T LH+A    + K AL LLE  A  + +  ++G T L +A +     +   + 
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT-AKNGYTPLHIAAKKNQMQIASTLL 628

Query: 677 TRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD---ATCWGPGPGGCLQTLLHRA 733
             GA+ ++  ++G  PL LA      D+ + L+  G +   +T  G        T LH A
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG-------LTSLHLA 681

Query: 734 IDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEF 793
             E+    A  L + G D ++              + G TPL +A  +G  + V  LL+ 
Sbjct: 682 AQEDKVNVADILTKHGADQDA------------HTKLGYTPLIVACHYGNVKMVNFLLKQ 729

Query: 794 GANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKS 853
           GANVNA+   G TP+H A    H  II +L+ H           G  P A   T  N  +
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH-----------GAKPNA---TTANGNT 775

Query: 854 AEAILKR 860
           A AI KR
Sbjct: 776 ALAIAKR 782


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  208 bits (529), Expect = 3e-53
 Identities = 215/837 (25%), Positives = 348/837 (41%), Gaps = 106/837 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG  AL LA       +   L+   + VD   K G + LH     G       L
Sbjct: 57   INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +K GA +NA +     TPL++ A    +++  DV+       + LL+ GAN +     G 
Sbjct: 117  VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 164

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428
            TPL V++  G+    + LL+         D +G     L   HI                
Sbjct: 165  TPLAVALQQGHNQAVAILLE--------NDTKGKVR--LPALHIAARK------------ 202

Query: 429  VNGTSFDENSFAARLIQRGSHTDAPD-------TATGNCLLQRAAGAGNEAAALFLATNG 481
                  D+   AA L+Q   + D          T +G   L  AA  GN   A  L   G
Sbjct: 203  ------DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 482  AHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSV 541
            A V+   + G TPLH A + G  N+   LL +G   + +T + L                
Sbjct: 257  AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL---------------- 300

Query: 542  HLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601
               TPLH A    H  VV ++LE+ A  L  T N               + L +A     
Sbjct: 301  ---TPLHCAARSGHDQVVELLLERGAPLLARTKN-------------GLSPLHMAAQGDH 344

Query: 602  HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661
                  LL   A ++D   D  T LH+A      +    LL+ +A+ N +R  +G T L 
Sbjct: 345  VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN-ARALNGFTPLH 403

Query: 662  LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721
            +A +     V++ +   GA +    E G  P+ +A      +I   L+++G         
Sbjct: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463

Query: 722  PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASW 781
                 +T LH A           L+R+G  V++             AR+ QTPLH+A+  
Sbjct: 464  G----ETALHMAARAGQVEVVRCLLRNGALVDA------------RAREEQTPLHIASRL 507

Query: 782  GLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP 841
            G  E VQ LL+  A+ +A    G TP+H++       +  +L+     H ++  ++G TP
Sbjct: 508  GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTP 566

Query: 842  FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
               A  + +   A+ +L+R + AA+     G   LHVA    + +  L L+   A+ ++ 
Sbjct: 567  LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625

Query: 902  VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961
             ++    TPLH+A +     I   LL  GA+ N +TK   T LHLA+Q+    + ++LL+
Sbjct: 626  AKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 962  NGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKEN 1021
             G +     ++G  +LHLA    ++ N+  +LT+   D +A    G +PL +   YG  N
Sbjct: 684  KGANIHMSTKSGLTSLHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYG--N 740

Query: 1022 AAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
               +  L  +   G  ++    +G T L  A  +G+ ++   +++ GA+       G
Sbjct: 741  VKMVNFLLKQ---GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794



 Score =  173 bits (439), Expect = 8e-43
 Identities = 188/668 (28%), Positives = 282/668 (42%), Gaps = 71/668 (10%)

Query: 453  PDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ 512
            P  +  N    RAA AGN    +     G  +N  N+ G   LH A + G   L  ELL 
Sbjct: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 513  QGANPNL----------------QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHP 556
            +G++ +                 Q E    L KE A++   A S +  TPL+MA   NH 
Sbjct: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHI 143

Query: 557  DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
            DVV  +LE  AN   AT +               T L +AL  G +   A LL      N
Sbjct: 144  DVVKYLLENGANQSTATED-------------GFTPLAVALQQGHNQAVAILLE-----N 185

Query: 617  DTMSDGQ-TLLHMAIQRQDSKSALFLL--EHQADIN----VSR-TQDGETALQLAIRNQL 668
            DT    +   LH+A ++ D+KSA  LL  +H AD+     V+R T+ G T L +A     
Sbjct: 186  DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245

Query: 669  PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG--CDA-TCWGPGPGGC 725
              V   +  RGA +      G  PL +A      ++   L+  G   DA T  G  P  C
Sbjct: 246  VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305

Query: 726  LQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEAR--------------DG 771
                 H  + E        L+    +  SP    A G+  E  +              D 
Sbjct: 306  AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365

Query: 772  QTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL 831
             T LH+AA  G     + LL+  AN NA+   G TP+H+A       +++LLV +    +
Sbjct: 366  LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASI 424

Query: 832  NVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFL 891
                  GLTP   A  F  + +   +L +   + +  + +G   LH+A +   +E V  L
Sbjct: 425  QAITESGLTPIHVA-AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 892  ISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQD 951
            +   A V++R ++  + TPLH+A + G   IV+ LL   A  +  T +  T LH++A++ 
Sbjct: 484  LRNGALVDARARE--EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 952  LPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPL 1011
               + SVLLE G   +   + G   LH+A  +G L ++  LL +    A++    G +PL
Sbjct: 542  QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL-DVAKLLLQRRAAADSAGKNGLTPL 600

Query: 1012 HILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARL 1071
            H+   Y  +  A    L LE   G        +G T L +A  K    +   ++  GA  
Sbjct: 601  HVAAHYDNQKVAL---LLLE--KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655

Query: 1072 GVNNNQGV 1079
             +   QGV
Sbjct: 656  NIVTKQGV 663



 Score =  150 bits (380), Expect = 5e-36
 Identities = 187/667 (28%), Positives = 274/667 (41%), Gaps = 115/667 (17%)

Query: 242 DSQLPGKLNEADHNGDLALDLALSRRLES---------------IATTLVSHKADVDMVD 286
           D++    L + DHN D+   + ++R  ES               +AT L++  A VD   
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 287 KSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEM 346
           ++G + LH   +RG+      L+  G  ++A T     TPLH  A            S  
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAA-----------RSGH 311

Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK-QLDLELKDHEGSTAL 405
            Q+ E LL+ GA    +   G +PLH++    +      LLQ K  +D    D+   TAL
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY--LTAL 369

Query: 406 WLAVQ--HITVSS---DQSVNPFEDVPVVNGTSFDENSFAAR---------LIQRGSHTD 451
            +A    H  V+    D+  NP  +   +NG  F     A +         L++ G+   
Sbjct: 370 HVAAHCGHYRVTKLLLDKRANP--NARALNG--FTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 452 APDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELL 511
           A  T +G   +  AA  G+    L L  NGA  +  N  GET LH A R G   +   LL
Sbjct: 426 A-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484

Query: 512 QQGANPNLQTEEALPLPKEAASLTSLADSVHL---------------QTPLHMAIAYNHP 556
           + GA  + +  E    P   AS     + V L                TPLH++      
Sbjct: 485 RNGALVDARAREE-QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 557 DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
           DV SV+LE  A A H           SL   +  T L +A   G   +A  LL   AA +
Sbjct: 544 DVASVLLE--AGAAH-----------SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 617 DTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAIC 676
               +G T LH+A    + K AL LLE  A  + +  ++G T L +A +     +   + 
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT-AKNGYTPLHIAAKKNQMQIASTLL 649

Query: 677 TRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD---ATCWGPGPGGCLQTLLHRA 733
             GA+ ++  ++G  PL LA      D+ + L+  G +   +T  G        T LH A
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG-------LTSLHLA 702

Query: 734 IDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEF 793
             E+    A  L + G D ++              + G TPL +A  +G  + V  LL+ 
Sbjct: 703 AQEDKVNVADILTKHGADQDA------------HTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 794 GANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKS 853
           GANVNA+   G TP+H A    H  II +L+ H           G  P A   T  N  +
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH-----------GAKPNA---TTANGNT 796

Query: 854 AEAILKR 860
           A AI KR
Sbjct: 797 ALAIAKR 803


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  208 bits (529), Expect = 3e-53
 Identities = 215/837 (25%), Positives = 348/837 (41%), Gaps = 106/837 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG  AL LA       +   L+   + VD   K G + LH     G       L
Sbjct: 57   INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +K GA +NA +     TPL++ A    +++  DV+       + LL+ GAN +     G 
Sbjct: 117  VKEGANINAQSQNG-FTPLYMAA----QENHIDVV-------KYLLENGANQSTATEDGF 164

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428
            TPL V++  G+    + LL+         D +G     L   HI                
Sbjct: 165  TPLAVALQQGHNQAVAILLE--------NDTKGKVR--LPALHIAARK------------ 202

Query: 429  VNGTSFDENSFAARLIQRGSHTDAPD-------TATGNCLLQRAAGAGNEAAALFLATNG 481
                  D+   AA L+Q   + D          T +G   L  AA  GN   A  L   G
Sbjct: 203  ------DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 482  AHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSV 541
            A V+   + G TPLH A + G  N+   LL +G   + +T + L                
Sbjct: 257  AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL---------------- 300

Query: 542  HLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601
               TPLH A    H  VV ++LE+ A  L  T N               + L +A     
Sbjct: 301  ---TPLHCAARSGHDQVVELLLERGAPLLARTKN-------------GLSPLHMAAQGDH 344

Query: 602  HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661
                  LL   A ++D   D  T LH+A      +    LL+ +A+ N +R  +G T L 
Sbjct: 345  VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN-ARALNGFTPLH 403

Query: 662  LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721
            +A +     V++ +   GA +    E G  P+ +A      +I   L+++G         
Sbjct: 404  IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463

Query: 722  PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASW 781
                 +T LH A           L+R+G  V++             AR+ QTPLH+A+  
Sbjct: 464  G----ETALHMAARAGQVEVVRCLLRNGALVDA------------RAREEQTPLHIASRL 507

Query: 782  GLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP 841
            G  E VQ LL+  A+ +A    G TP+H++       +  +L+     H ++  ++G TP
Sbjct: 508  GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH-SLATKKGFTP 566

Query: 842  FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
               A  + +   A+ +L+R + AA+     G   LHVA    + +  L L+   A+ ++ 
Sbjct: 567  LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625

Query: 902  VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961
             ++    TPLH+A +     I   LL  GA+ N +TK   T LHLA+Q+    + ++LL+
Sbjct: 626  AKNG--YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683

Query: 962  NGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKEN 1021
             G +     ++G  +LHLA    ++ N+  +LT+   D +A    G +PL +   YG  N
Sbjct: 684  KGANIHMSTKSGLTSLHLAAQEDKV-NVADILTKHGADQDAHTKLGYTPLIVACHYG--N 740

Query: 1022 AAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
               +  L  +   G  ++    +G T L  A  +G+ ++   +++ GA+       G
Sbjct: 741  VKMVNFLLKQ---GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794



 Score =  173 bits (439), Expect = 8e-43
 Identities = 188/668 (28%), Positives = 282/668 (42%), Gaps = 71/668 (10%)

Query: 453  PDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ 512
            P  +  N    RAA AGN    +     G  +N  N+ G   LH A + G   L  ELL 
Sbjct: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 513  QGANPNL----------------QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHP 556
            +G++ +                 Q E    L KE A++   A S +  TPL+MA   NH 
Sbjct: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN--AQSQNGFTPLYMAAQENHI 143

Query: 557  DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
            DVV  +LE  AN   AT +               T L +AL  G +   A LL      N
Sbjct: 144  DVVKYLLENGANQSTATED-------------GFTPLAVALQQGHNQAVAILLE-----N 185

Query: 617  DTMSDGQ-TLLHMAIQRQDSKSALFLL--EHQADIN----VSR-TQDGETALQLAIRNQL 668
            DT    +   LH+A ++ D+KSA  LL  +H AD+     V+R T+ G T L +A     
Sbjct: 186  DTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN 245

Query: 669  PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG--CDA-TCWGPGPGGC 725
              V   +  RGA +      G  PL +A      ++   L+  G   DA T  G  P  C
Sbjct: 246  VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305

Query: 726  LQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEAR--------------DG 771
                 H  + E        L+    +  SP    A G+  E  +              D 
Sbjct: 306  AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY 365

Query: 772  QTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL 831
             T LH+AA  G     + LL+  AN NA+   G TP+H+A       +++LLV +    +
Sbjct: 366  LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASI 424

Query: 832  NVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFL 891
                  GLTP   A  F  + +   +L +   + +  + +G   LH+A +   +E V  L
Sbjct: 425  QAITESGLTPIHVA-AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 892  ISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQD 951
            +   A V++R ++  + TPLH+A + G   IV+ LL   A  +  T +  T LH++A++ 
Sbjct: 484  LRNGALVDARARE--EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 952  LPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPL 1011
               + SVLLE G   +   + G   LH+A  +G L ++  LL +    A++    G +PL
Sbjct: 542  QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL-DVAKLLLQRRAAADSAGKNGLTPL 600

Query: 1012 HILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARL 1071
            H+   Y  +  A    L LE   G        +G T L +A  K    +   ++  GA  
Sbjct: 601  HVAAHYDNQKVAL---LLLE--KGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655

Query: 1072 GVNNNQGV 1079
             +   QGV
Sbjct: 656  NIVTKQGV 663



 Score =  150 bits (380), Expect = 5e-36
 Identities = 187/667 (28%), Positives = 274/667 (41%), Gaps = 115/667 (17%)

Query: 242 DSQLPGKLNEADHNGDLALDLALSRRLES---------------IATTLVSHKADVDMVD 286
           D++    L + DHN D+   + ++R  ES               +AT L++  A VD   
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 287 KSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEM 346
           ++G + LH   +RG+      L+  G  ++A T     TPLH  A            S  
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAA-----------RSGH 311

Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK-QLDLELKDHEGSTAL 405
            Q+ E LL+ GA    +   G +PLH++    +      LLQ K  +D    D+   TAL
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY--LTAL 369

Query: 406 WLAVQ--HITVSS---DQSVNPFEDVPVVNGTSFDENSFAAR---------LIQRGSHTD 451
            +A    H  V+    D+  NP  +   +NG  F     A +         L++ G+   
Sbjct: 370 HVAAHCGHYRVTKLLLDKRANP--NARALNG--FTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 452 APDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELL 511
           A  T +G   +  AA  G+    L L  NGA  +  N  GET LH A R G   +   LL
Sbjct: 426 A-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484

Query: 512 QQGANPNLQTEEALPLPKEAASLTSLADSVHL---------------QTPLHMAIAYNHP 556
           + GA  + +  E    P   AS     + V L                TPLH++      
Sbjct: 485 RNGALVDARAREE-QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 557 DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
           DV SV+LE  A A H           SL   +  T L +A   G   +A  LL   AA +
Sbjct: 544 DVASVLLE--AGAAH-----------SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590

Query: 617 DTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAIC 676
               +G T LH+A    + K AL LLE  A  + +  ++G T L +A +     +   + 
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT-AKNGYTPLHIAAKKNQMQIASTLL 649

Query: 677 TRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD---ATCWGPGPGGCLQTLLHRA 733
             GA+ ++  ++G  PL LA      D+ + L+  G +   +T  G        T LH A
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG-------LTSLHLA 702

Query: 734 IDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEF 793
             E+    A  L + G D ++              + G TPL +A  +G  + V  LL+ 
Sbjct: 703 AQEDKVNVADILTKHGADQDA------------HTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 794 GANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKS 853
           GANVNA+   G TP+H A    H  II +L+ H           G  P A   T  N  +
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH-----------GAKPNA---TTANGNT 796

Query: 854 AEAILKR 860
           A AI KR
Sbjct: 797 ALAIAKR 803


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  197 bits (502), Expect = 4e-50
 Identities = 221/824 (26%), Positives = 337/824 (40%), Gaps = 99/824 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG   L LA       +   L+  +  ++   K G + LH     G       L
Sbjct: 71   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +  GA VNA +     TPL++ A                ++ + LL+ GAN N+    G 
Sbjct: 131  VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 178

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV-------- 420
            TPL V++  G+E V + L+          ++     + L   HI   +D +         
Sbjct: 179  TPLAVALQQGHENVVAHLI----------NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 228

Query: 421  NPFEDV-------PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAA 473
            +P  DV       P+     ++  + A  L+ RG+  +      G   L  A+  GN   
Sbjct: 229  DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIM 287

Query: 474  ALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAAS 533
               L   GA +  + K   TPLH A R+G   ++  LL  GA    +T+  L        
Sbjct: 288  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-------- 339

Query: 534  LTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVL 593
                       +P+HMA   +H D V ++L+  A           I D +L      T L
Sbjct: 340  -----------SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPL 375

Query: 594  GLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRT 653
             +A   G H +A  LL  GA  N    +G T LH+A ++   +    LL+  A I+   T
Sbjct: 376  HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-T 434

Query: 654  QDGETALQLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
            + G T L +A     LP+V + +  RGA  +V + K   PL +A      ++A  L+++ 
Sbjct: 435  ESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493

Query: 713  CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
                          QT LH A    +      L+ +  + N     G             
Sbjct: 494  AKVNAKAKDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------H 537

Query: 773  TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
            TPLH+AA  G  ETV  LLE  A+      +G TP+HVA       + +LL+   D H N
Sbjct: 538  TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPN 596

Query: 833  VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLI 892
               + GLTP   A+   N    + +L R  G+       G   LH+A + + +E    L+
Sbjct: 597  AAGKNGLTPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655

Query: 893  SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
                + N+  +    +TPLHLA Q G   +V  LL   A  N   K   T LHL AQ+  
Sbjct: 656  QYGGSANA--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713

Query: 953  PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLH 1012
              +  VL+++GV   A    G   LH+A  +G +  ++ LL +   D  A    G SPLH
Sbjct: 714  VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLH 772

Query: 1013 ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
               Q G  +   I  L L+   G   ++  +DG+T L +A   G
Sbjct: 773  QAAQQGHTD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 811



 Score =  186 bits (473), Expect = 9e-47
 Identities = 204/771 (26%), Positives = 315/771 (40%), Gaps = 115/771 (14%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           L      G+ AL +A     + +   LV++ A+V+   + G++ L+   Q   L    FL
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 309 IKNGAFVNAAT------------LGAQETPLHLV-----------ALYSSKKH------- 338
           ++NGA  N AT             G +    HL+           AL+ + ++       
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223

Query: 339 -------SADVMS-------------EMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
                  + DV+S             E   +A+ LL  GA+ N     G TPLH++   G
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283

Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITVSSD--------QSVNPFEDVPV 428
           N  +  +LL  +   +E K  +  T L  A +  H+ +S          Q+       P+
Sbjct: 284 N-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                 D       L+Q  +  D   T      L  AA  G+   A  L   GA  N R 
Sbjct: 343 HMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
             G TPLH AC+     +   LL+ GA+ +  TE  L                   TPLH
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-------------------TPLH 442

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
           +A    H  +V  +L++ A+              ++ + + +T L +A   G   +A  L
Sbjct: 443 VASFMGHLPIVKNLLQRGASP-------------NVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 609 LGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQL 668
           L + A +N    D QT LH A +   +     LLE+ A+ N++ T  G T L +A R   
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGH 548

Query: 669 PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQT 728
              V A+  + A  +   +KG  PL +A       +A  L+    DA     G  G   T
Sbjct: 549 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--T 604

Query: 729 LLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQ 788
            LH A+  NN      L+  G    SP  P  NG          TPLH+AA     E  +
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNG---------YTPLHIAAKQNQVEVAR 652

Query: 789 CLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTF 848
            LL++G + NA+  +G TP+H+A    H  ++ LL+S    + N+ ++ GLTP       
Sbjct: 653 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQE 711

Query: 849 KNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKL 908
            +   A+ ++K      +     G   LHVA    +I+ V FL+   A+VN++ +     
Sbjct: 712 GHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGY 768

Query: 909 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
           +PLH A Q G   IV  LL  GA  NE++    T L +A +    ++  VL
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score =  152 bits (385), Expect = 1e-36
 Identities = 164/638 (25%), Positives = 261/638 (40%), Gaps = 58/638 (9%)

Query: 445  QRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLA 504
            +R    D    A       RAA +GN   AL    NG  +N  N+ G   LH A + G  
Sbjct: 32   RRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHV 91

Query: 505  NLTAELLQQG---------ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMA 550
             +  ELL +           N  L         +    L +   +V+ Q     TPL+MA
Sbjct: 92   KMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 151

Query: 551  IAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLG 610
               NH +VV  +LE  AN   AT +               T L +AL  G   + A L+ 
Sbjct: 152  AQENHLEVVKFLLENGANQNVATED-------------GFTPLAVALQQGHENVVAHLIN 198

Query: 611  SGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPL 670
             G      +      LH+A +  D+++A  LL++  + +V  ++ G T L +A   +   
Sbjct: 199  YGTKGKVRLP----ALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAAHYENLN 253

Query: 671  VVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLL 730
            V   +  RGA ++   + G  PL +A       +   L+  G               T L
Sbjct: 254  VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPL 309

Query: 731  HRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCL 790
            H A    +   +  L+  G  + +            + ++G +P+H+AA     + V+ L
Sbjct: 310  HCAARNGHVRISEILLDHGAPIQA------------KTKNGLSPIHMAAQGDHLDCVRLL 357

Query: 791  LEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKN 850
            L++ A ++    +  TP+HVA    H  + ++L+       N R   G TP   A   KN
Sbjct: 358  LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACK-KN 415

Query: 851  NKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTP 910
            +     +L +   + + V   G   LHVA     +  V  L+   A+ N  V +    TP
Sbjct: 416  HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETP 473

Query: 911  LHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVD 970
            LH+A +AG   + + LL   AKVN   K  QT LH AA+     +  +LLEN  +     
Sbjct: 474  LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533

Query: 971  ENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFL 1030
              G+  LH+A   G +  +  LL E          +G +PLH+  +YGK   A   +L L
Sbjct: 534  TAGHTPLHIAAREGHVETVLALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLL 589

Query: 1031 ECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSG 1068
            E    +P +    +G T L +A    N ++ + ++  G
Sbjct: 590  E-RDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625



 Score =  144 bits (364), Expect = 4e-34
 Identities = 128/487 (26%), Positives = 216/487 (44%), Gaps = 33/487 (6%)

Query: 593  LGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSR 652
            L LA   G   +  +LL     +  T   G T LH+A      +    L+ + A++N ++
Sbjct: 82   LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQ 140

Query: 653  TQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
            +Q G T L +A +     VV  +   GA+ +V  E G  PL +AL    E++ + L+ +G
Sbjct: 141  SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200

Query: 713  CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
                   P         LH A   ++  TA  L++     N P         +  ++ G 
Sbjct: 201  TKGKVRLPA--------LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGF 240

Query: 773  TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
            TPLH+AA +      Q LL  GA+VN     G TP+H+A    + ++++LL+      + 
Sbjct: 241  TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIE 299

Query: 833  VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFL 891
             + +  LTP  CA    + + +E +L  + GA  Q   K G + +H+A Q   ++ V  L
Sbjct: 300  TKTKDELTPLHCAARNGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357

Query: 892  ISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQD 951
            +   A ++    D   LTPLH+A   G   + + LL  GAK N    +  T LH+A +++
Sbjct: 358  LQYDAEIDDITLD--HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415

Query: 952  LPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPL 1011
               +  +LL+ G    AV E+G   LH+A   G L  ++ LL +        N++ ++PL
Sbjct: 416  HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPL 474

Query: 1012 HILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARL 1071
            H+  + G    A              ++    D  T L  A   G+ N+ + ++ + A  
Sbjct: 475  HMAARAGHTEVAKYL-----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529

Query: 1072 GVNNNQG 1078
             +    G
Sbjct: 530  NLATTAG 536



 Score =  128 bits (321), Expect = 4e-29
 Identities = 104/397 (26%), Positives = 173/397 (43%), Gaps = 58/397 (14%)

Query: 732  RAIDENNEPTACFLIRSGCDVNSPRQPGANG------EG---------------EEEARD 770
            RA    N   A   +R+G D+N+  Q G NG      EG               E   + 
Sbjct: 51   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 110

Query: 771  GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIH 830
            G T LH+AA  G +E V+ L+ +GANVNAQ  +G TP+++A    H  +++ L+ +   +
Sbjct: 111  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GAN 169

Query: 831  LNVRDRQGLTPFACAM----------------------------TFKNNKSAEAILKRES 862
             NV    G TP A A+                               ++    A+L +  
Sbjct: 170  QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 229

Query: 863  GAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEII 922
               + +   G   LH+A    ++     L++  A+VN   Q+   +TPLH+A + G+ I+
Sbjct: 230  PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG--ITPLHIASRRGNVIM 287

Query: 923  VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            VR LL  GA++   TK   T LH AA+     I  +LL++G    A  +NG + +H+A  
Sbjct: 288  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 347

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPD 1042
               L+ +R+LL +   + +   L   +PLH+    G    A +         G   +   
Sbjct: 348  GDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-----LDKGAKPNSRA 401

Query: 1043 ADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
             +G T L +A  K +  +   ++++GA +      G+
Sbjct: 402  LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 438


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  197 bits (502), Expect = 4e-50
 Identities = 221/824 (26%), Positives = 337/824 (40%), Gaps = 99/824 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG   L LA       +   L+  +  ++   K G + LH     G       L
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +  GA VNA +     TPL++ A                ++ + LL+ GAN N+    G 
Sbjct: 98   VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV-------- 420
            TPL V++  G+E V + L+          ++     + L   HI   +D +         
Sbjct: 146  TPLAVALQQGHENVVAHLI----------NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 421  NPFEDV-------PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAA 473
            +P  DV       P+     ++  + A  L+ RG+  +      G   L  A+  GN   
Sbjct: 196  DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIM 254

Query: 474  ALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAAS 533
               L   GA +  + K   TPLH A R+G   ++  LL  GA    +T+  L        
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-------- 306

Query: 534  LTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVL 593
                       +P+HMA   +H D V ++L+  A           I D +L      T L
Sbjct: 307  -----------SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPL 342

Query: 594  GLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRT 653
             +A   G H +A  LL  GA  N    +G T LH+A ++   +    LL+  A I+   T
Sbjct: 343  HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-T 401

Query: 654  QDGETALQLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
            + G T L +A     LP+V + +  RGA  +V + K   PL +A      ++A  L+++ 
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460

Query: 713  CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
                          QT LH A    +      L+ +  + N     G             
Sbjct: 461  AKVNAKAKDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------H 504

Query: 773  TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
            TPLH+AA  G  ETV  LLE  A+      +G TP+HVA       + +LL+   D H N
Sbjct: 505  TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPN 563

Query: 833  VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLI 892
               + GLTP   A+   N    + +L R  G+       G   LH+A + + +E    L+
Sbjct: 564  AAGKNGLTPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 893  SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
                + N+  +    +TPLHLA Q G   +V  LL   A  N   K   T LHL AQ+  
Sbjct: 623  QYGGSANA--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680

Query: 953  PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLH 1012
              +  VL+++GV   A    G   LH+A  +G +  ++ LL +   D  A    G SPLH
Sbjct: 681  VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLH 739

Query: 1013 ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
               Q G  +   I  L L+   G   ++  +DG+T L +A   G
Sbjct: 740  QAAQQGHTD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 778



 Score =  186 bits (473), Expect = 9e-47
 Identities = 204/771 (26%), Positives = 315/771 (40%), Gaps = 115/771 (14%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           L      G+ AL +A     + +   LV++ A+V+   + G++ L+   Q   L    FL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 309 IKNGAFVNAAT------------LGAQETPLHLV-----------ALYSSKKH------- 338
           ++NGA  N AT             G +    HL+           AL+ + ++       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 339 -------SADVMS-------------EMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
                  + DV+S             E   +A+ LL  GA+ N     G TPLH++   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITVSSD--------QSVNPFEDVPV 428
           N  +  +LL  +   +E K  +  T L  A +  H+ +S          Q+       P+
Sbjct: 251 N-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                 D       L+Q  +  D   T      L  AA  G+   A  L   GA  N R 
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
             G TPLH AC+     +   LL+ GA+ +  TE  L                   TPLH
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-------------------TPLH 409

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
           +A    H  +V  +L++ A+              ++ + + +T L +A   G   +A  L
Sbjct: 410 VASFMGHLPIVKNLLQRGASP-------------NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 609 LGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQL 668
           L + A +N    D QT LH A +   +     LLE+ A+ N++ T  G T L +A R   
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGH 515

Query: 669 PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQT 728
              V A+  + A  +   +KG  PL +A       +A  L+    DA     G  G   T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--T 571

Query: 729 LLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQ 788
            LH A+  NN      L+  G    SP  P  NG          TPLH+AA     E  +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNG---------YTPLHIAAKQNQVEVAR 619

Query: 789 CLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTF 848
            LL++G + NA+  +G TP+H+A    H  ++ LL+S    + N+ ++ GLTP       
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQE 678

Query: 849 KNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKL 908
            +   A+ ++K      +     G   LHVA    +I+ V FL+   A+VN++ +     
Sbjct: 679 GHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGY 735

Query: 909 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
           +PLH A Q G   IV  LL  GA  NE++    T L +A +    ++  VL
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  152 bits (384), Expect = 2e-36
 Identities = 161/619 (26%), Positives = 257/619 (41%), Gaps = 58/619 (9%)

Query: 464  RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG--------- 514
            RAA +GN   AL    NG  +N  N+ G   LH A + G   +  ELL +          
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 515  ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANA 569
             N  L         +    L +   +V+ Q     TPL+MA   NH +VV  +LE  AN 
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 570  LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
              AT +               T L +AL  G   + A L+  G      +      LH+A
Sbjct: 138  NVATED-------------GFTPLAVALQQGHENVVAHLINYGTKGKVRLP----ALHIA 180

Query: 630  IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
             +  D+++A  LL++  + +V  ++ G T L +A   +   V   +  RGA ++   + G
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 690  NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
              PL +A       +   L+  G               T LH A    +   +  L+  G
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHG 295

Query: 750  CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
              + +            + ++G +P+H+AA     + V+ LL++ A ++    +  TP+H
Sbjct: 296  APIQA------------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343

Query: 810  VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
            VA    H  + ++L+       N R   G TP   A   KN+     +L +   + + V 
Sbjct: 344  VAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVT 401

Query: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
              G   LHVA     +  V  L+   A+ N  V +    TPLH+A +AG   + + LL  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETPLHMAARAGHTEVAKYLLQN 459

Query: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
             AKVN   K  QT LH AA+     +  +LLEN  +       G+  LH+A   G +  +
Sbjct: 460  KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 990  RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049
              LL E          +G +PLH+  +YGK   A   +L LE    +P +    +G T L
Sbjct: 520  LALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLLE-RDAHP-NAAGKNGLTPL 573

Query: 1050 LLAYMKGNANLCRAIVRSG 1068
             +A    N ++ + ++  G
Sbjct: 574  HVAVHHNNLDIVKLLLPRG 592



 Score =  145 bits (366), Expect = 2e-34
 Identities = 134/532 (25%), Positives = 232/532 (43%), Gaps = 35/532 (6%)

Query: 550  AIAYNHPDVVSVILE--QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607
            ++ +   D  +  L   +  N   A ++L+   D +  +      L LA   G   +  +
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 608  LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
            LL     +  T   G T LH+A      +    L+ + A++N +++Q G T L +A +  
Sbjct: 64   LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQEN 122

Query: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
               VV  +   GA+ +V  E G  PL +AL    E++ + L+ +G       P       
Sbjct: 123  HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------ 176

Query: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
              LH A   ++  TA  L++     N P         +  ++ G TPLH+AA +      
Sbjct: 177  --LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGFTPLHIAAHYENLNVA 222

Query: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847
            Q LL  GA+VN     G TP+H+A    + ++++LL+      +  + +  LTP  CA  
Sbjct: 223  QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIETKTKDELTPLHCAAR 281

Query: 848  FKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDAS 906
              + + +E +L  + GA  Q   K G + +H+A Q   ++ V  L+   A ++    D  
Sbjct: 282  NGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-- 337

Query: 907  KLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDF 966
             LTPLH+A   G   + + LL  GAK N    +  T LH+A +++   +  +LL+ G   
Sbjct: 338  HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 967  AAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF 1026
             AV E+G   LH+A   G L  ++ LL +        N++ ++PLH+  + G    A   
Sbjct: 398  DAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
                       ++    D  T L  A   G+ N+ + ++ + A   +    G
Sbjct: 457  -----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503



 Score =  128 bits (321), Expect = 4e-29
 Identities = 104/397 (26%), Positives = 173/397 (43%), Gaps = 58/397 (14%)

Query: 732  RAIDENNEPTACFLIRSGCDVNSPRQPGANG------EG---------------EEEARD 770
            RA    N   A   +R+G D+N+  Q G NG      EG               E   + 
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 771  GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIH 830
            G T LH+AA  G +E V+ L+ +GANVNAQ  +G TP+++A    H  +++ L+ +   +
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GAN 136

Query: 831  LNVRDRQGLTPFACAM----------------------------TFKNNKSAEAILKRES 862
             NV    G TP A A+                               ++    A+L +  
Sbjct: 137  QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 863  GAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEII 922
               + +   G   LH+A    ++     L++  A+VN   Q+   +TPLH+A + G+ I+
Sbjct: 197  PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG--ITPLHIASRRGNVIM 254

Query: 923  VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            VR LL  GA++   TK   T LH AA+     I  +LL++G    A  +NG + +H+A  
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPD 1042
               L+ +R+LL +   + +   L   +PLH+    G    A +         G   +   
Sbjct: 315  GDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-----LDKGAKPNSRA 368

Query: 1043 ADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
             +G T L +A  K +  +   ++++GA +      G+
Sbjct: 369  LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  197 bits (502), Expect = 4e-50
 Identities = 221/824 (26%), Positives = 337/824 (40%), Gaps = 99/824 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG   L LA       +   L+  +  ++   K G + LH     G       L
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +  GA VNA +     TPL++ A                ++ + LL+ GAN N+    G 
Sbjct: 98   VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV-------- 420
            TPL V++  G+E V + L+          ++     + L   HI   +D +         
Sbjct: 146  TPLAVALQQGHENVVAHLI----------NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 421  NPFEDV-------PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAA 473
            +P  DV       P+     ++  + A  L+ RG+  +      G   L  A+  GN   
Sbjct: 196  DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIM 254

Query: 474  ALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAAS 533
               L   GA +  + K   TPLH A R+G   ++  LL  GA    +T+  L        
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-------- 306

Query: 534  LTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVL 593
                       +P+HMA   +H D V ++L+  A           I D +L      T L
Sbjct: 307  -----------SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPL 342

Query: 594  GLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRT 653
             +A   G H +A  LL  GA  N    +G T LH+A ++   +    LL+  A I+   T
Sbjct: 343  HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-T 401

Query: 654  QDGETALQLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
            + G T L +A     LP+V + +  RGA  +V + K   PL +A      ++A  L+++ 
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460

Query: 713  CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
                          QT LH A    +      L+ +  + N     G             
Sbjct: 461  AKVNAKAKDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------H 504

Query: 773  TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
            TPLH+AA  G  ETV  LLE  A+      +G TP+HVA       + +LL+   D H N
Sbjct: 505  TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPN 563

Query: 833  VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLI 892
               + GLTP   A+   N    + +L R  G+       G   LH+A + + +E    L+
Sbjct: 564  AAGKNGLTPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 893  SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
                + N+  +    +TPLHLA Q G   +V  LL   A  N   K   T LHL AQ+  
Sbjct: 623  QYGGSANA--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680

Query: 953  PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLH 1012
              +  VL+++GV   A    G   LH+A  +G +  ++ LL +   D  A    G SPLH
Sbjct: 681  VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLH 739

Query: 1013 ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
               Q G  +   I  L L+   G   ++  +DG+T L +A   G
Sbjct: 740  QAAQQGHTD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 778



 Score =  186 bits (473), Expect = 9e-47
 Identities = 204/771 (26%), Positives = 315/771 (40%), Gaps = 115/771 (14%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           L      G+ AL +A     + +   LV++ A+V+   + G++ L+   Q   L    FL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 309 IKNGAFVNAAT------------LGAQETPLHLV-----------ALYSSKKH------- 338
           ++NGA  N AT             G +    HL+           AL+ + ++       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 339 -------SADVMS-------------EMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
                  + DV+S             E   +A+ LL  GA+ N     G TPLH++   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITVSSD--------QSVNPFEDVPV 428
           N  +  +LL  +   +E K  +  T L  A +  H+ +S          Q+       P+
Sbjct: 251 N-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                 D       L+Q  +  D   T      L  AA  G+   A  L   GA  N R 
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
             G TPLH AC+     +   LL+ GA+ +  TE  L                   TPLH
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-------------------TPLH 409

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
           +A    H  +V  +L++ A+              ++ + + +T L +A   G   +A  L
Sbjct: 410 VASFMGHLPIVKNLLQRGASP-------------NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 609 LGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQL 668
           L + A +N    D QT LH A +   +     LLE+ A+ N++ T  G T L +A R   
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGH 515

Query: 669 PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQT 728
              V A+  + A  +   +KG  PL +A       +A  L+    DA     G  G   T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--T 571

Query: 729 LLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQ 788
            LH A+  NN      L+  G    SP  P  NG          TPLH+AA     E  +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNG---------YTPLHIAAKQNQVEVAR 619

Query: 789 CLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTF 848
            LL++G + NA+  +G TP+H+A    H  ++ LL+S    + N+ ++ GLTP       
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQE 678

Query: 849 KNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKL 908
            +   A+ ++K      +     G   LHVA    +I+ V FL+   A+VN++ +     
Sbjct: 679 GHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGY 735

Query: 909 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
           +PLH A Q G   IV  LL  GA  NE++    T L +A +    ++  VL
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  152 bits (384), Expect = 2e-36
 Identities = 161/619 (26%), Positives = 257/619 (41%), Gaps = 58/619 (9%)

Query: 464  RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG--------- 514
            RAA +GN   AL    NG  +N  N+ G   LH A + G   +  ELL +          
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 515  ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANA 569
             N  L         +    L +   +V+ Q     TPL+MA   NH +VV  +LE  AN 
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 570  LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
              AT +               T L +AL  G   + A L+  G      +      LH+A
Sbjct: 138  NVATED-------------GFTPLAVALQQGHENVVAHLINYGTKGKVRLP----ALHIA 180

Query: 630  IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
             +  D+++A  LL++  + +V  ++ G T L +A   +   V   +  RGA ++   + G
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 690  NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
              PL +A       +   L+  G               T LH A    +   +  L+  G
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHG 295

Query: 750  CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
              + +            + ++G +P+H+AA     + V+ LL++ A ++    +  TP+H
Sbjct: 296  APIQA------------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343

Query: 810  VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
            VA    H  + ++L+       N R   G TP   A   KN+     +L +   + + V 
Sbjct: 344  VAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVT 401

Query: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
              G   LHVA     +  V  L+   A+ N  V +    TPLH+A +AG   + + LL  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETPLHMAARAGHTEVAKYLLQN 459

Query: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
             AKVN   K  QT LH AA+     +  +LLEN  +       G+  LH+A   G +  +
Sbjct: 460  KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 990  RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049
              LL E          +G +PLH+  +YGK   A   +L LE    +P +    +G T L
Sbjct: 520  LALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLLE-RDAHP-NAAGKNGLTPL 573

Query: 1050 LLAYMKGNANLCRAIVRSG 1068
             +A    N ++ + ++  G
Sbjct: 574  HVAVHHNNLDIVKLLLPRG 592



 Score =  145 bits (366), Expect = 2e-34
 Identities = 134/532 (25%), Positives = 232/532 (43%), Gaps = 35/532 (6%)

Query: 550  AIAYNHPDVVSVILE--QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607
            ++ +   D  +  L   +  N   A ++L+   D +  +      L LA   G   +  +
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 608  LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
            LL     +  T   G T LH+A      +    L+ + A++N +++Q G T L +A +  
Sbjct: 64   LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQEN 122

Query: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
               VV  +   GA+ +V  E G  PL +AL    E++ + L+ +G       P       
Sbjct: 123  HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------ 176

Query: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
              LH A   ++  TA  L++     N P         +  ++ G TPLH+AA +      
Sbjct: 177  --LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGFTPLHIAAHYENLNVA 222

Query: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847
            Q LL  GA+VN     G TP+H+A    + ++++LL+      +  + +  LTP  CA  
Sbjct: 223  QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIETKTKDELTPLHCAAR 281

Query: 848  FKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDAS 906
              + + +E +L  + GA  Q   K G + +H+A Q   ++ V  L+   A ++    D  
Sbjct: 282  NGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-- 337

Query: 907  KLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDF 966
             LTPLH+A   G   + + LL  GAK N    +  T LH+A +++   +  +LL+ G   
Sbjct: 338  HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 967  AAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF 1026
             AV E+G   LH+A   G L  ++ LL +        N++ ++PLH+  + G    A   
Sbjct: 398  DAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
                       ++    D  T L  A   G+ N+ + ++ + A   +    G
Sbjct: 457  -----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503



 Score =  128 bits (321), Expect = 4e-29
 Identities = 104/397 (26%), Positives = 173/397 (43%), Gaps = 58/397 (14%)

Query: 732  RAIDENNEPTACFLIRSGCDVNSPRQPGANG------EG---------------EEEARD 770
            RA    N   A   +R+G D+N+  Q G NG      EG               E   + 
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 771  GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIH 830
            G T LH+AA  G +E V+ L+ +GANVNAQ  +G TP+++A    H  +++ L+ +   +
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GAN 136

Query: 831  LNVRDRQGLTPFACAM----------------------------TFKNNKSAEAILKRES 862
             NV    G TP A A+                               ++    A+L +  
Sbjct: 137  QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 863  GAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEII 922
               + +   G   LH+A    ++     L++  A+VN   Q+   +TPLH+A + G+ I+
Sbjct: 197  PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG--ITPLHIASRRGNVIM 254

Query: 923  VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            VR LL  GA++   TK   T LH AA+     I  +LL++G    A  +NG + +H+A  
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPD 1042
               L+ +R+LL +   + +   L   +PLH+    G    A +         G   +   
Sbjct: 315  GDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-----LDKGAKPNSRA 368

Query: 1043 ADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
             +G T L +A  K +  +   ++++GA +      G+
Sbjct: 369  LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  197 bits (502), Expect = 4e-50
 Identities = 221/824 (26%), Positives = 337/824 (40%), Gaps = 99/824 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG   L LA       +   L+  +  ++   K G + LH     G       L
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +  GA VNA +     TPL++ A                ++ + LL+ GAN N+    G 
Sbjct: 98   VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV-------- 420
            TPL V++  G+E V + L+          ++     + L   HI   +D +         
Sbjct: 146  TPLAVALQQGHENVVAHLI----------NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 421  NPFEDV-------PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAA 473
            +P  DV       P+     ++  + A  L+ RG+  +      G   L  A+  GN   
Sbjct: 196  DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIM 254

Query: 474  ALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAAS 533
               L   GA +  + K   TPLH A R+G   ++  LL  GA    +T+  L        
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-------- 306

Query: 534  LTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVL 593
                       +P+HMA   +H D V ++L+  A           I D +L      T L
Sbjct: 307  -----------SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPL 342

Query: 594  GLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRT 653
             +A   G H +A  LL  GA  N    +G T LH+A ++   +    LL+  A I+   T
Sbjct: 343  HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-T 401

Query: 654  QDGETALQLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
            + G T L +A     LP+V + +  RGA  +V + K   PL +A      ++A  L+++ 
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460

Query: 713  CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
                          QT LH A    +      L+ +  + N     G             
Sbjct: 461  AKVNAKAKDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------H 504

Query: 773  TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
            TPLH+AA  G  ETV  LLE  A+      +G TP+HVA       + +LL+   D H N
Sbjct: 505  TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPN 563

Query: 833  VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLI 892
               + GLTP   A+   N    + +L R  G+       G   LH+A + + +E    L+
Sbjct: 564  AAGKNGLTPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 893  SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
                + N+  +    +TPLHLA Q G   +V  LL   A  N   K   T LHL AQ+  
Sbjct: 623  QYGGSANA--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680

Query: 953  PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLH 1012
              +  VL+++GV   A    G   LH+A  +G +  ++ LL +   D  A    G SPLH
Sbjct: 681  VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLH 739

Query: 1013 ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
               Q G  +   I  L L+   G   ++  +DG+T L +A   G
Sbjct: 740  QAAQQGHTD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 778



 Score =  186 bits (473), Expect = 9e-47
 Identities = 204/771 (26%), Positives = 315/771 (40%), Gaps = 115/771 (14%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           L      G+ AL +A     + +   LV++ A+V+   + G++ L+   Q   L    FL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 309 IKNGAFVNAAT------------LGAQETPLHLV-----------ALYSSKKH------- 338
           ++NGA  N AT             G +    HL+           AL+ + ++       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 339 -------SADVMS-------------EMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
                  + DV+S             E   +A+ LL  GA+ N     G TPLH++   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITVSSD--------QSVNPFEDVPV 428
           N  +  +LL  +   +E K  +  T L  A +  H+ +S          Q+       P+
Sbjct: 251 N-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                 D       L+Q  +  D   T      L  AA  G+   A  L   GA  N R 
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
             G TPLH AC+     +   LL+ GA+ +  TE  L                   TPLH
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-------------------TPLH 409

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
           +A    H  +V  +L++ A+              ++ + + +T L +A   G   +A  L
Sbjct: 410 VASFMGHLPIVKNLLQRGASP-------------NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 609 LGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQL 668
           L + A +N    D QT LH A +   +     LLE+ A+ N++ T  G T L +A R   
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGH 515

Query: 669 PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQT 728
              V A+  + A  +   +KG  PL +A       +A  L+    DA     G  G   T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--T 571

Query: 729 LLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQ 788
            LH A+  NN      L+  G    SP  P  NG          TPLH+AA     E  +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNG---------YTPLHIAAKQNQVEVAR 619

Query: 789 CLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTF 848
            LL++G + NA+  +G TP+H+A    H  ++ LL+S    + N+ ++ GLTP       
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQE 678

Query: 849 KNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKL 908
            +   A+ ++K      +     G   LHVA    +I+ V FL+   A+VN++ +     
Sbjct: 679 GHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGY 735

Query: 909 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
           +PLH A Q G   IV  LL  GA  NE++    T L +A +    ++  VL
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  152 bits (384), Expect = 2e-36
 Identities = 161/619 (26%), Positives = 257/619 (41%), Gaps = 58/619 (9%)

Query: 464  RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG--------- 514
            RAA +GN   AL    NG  +N  N+ G   LH A + G   +  ELL +          
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 515  ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANA 569
             N  L         +    L +   +V+ Q     TPL+MA   NH +VV  +LE  AN 
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 570  LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
              AT +               T L +AL  G   + A L+  G      +      LH+A
Sbjct: 138  NVATED-------------GFTPLAVALQQGHENVVAHLINYGTKGKVRLP----ALHIA 180

Query: 630  IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
             +  D+++A  LL++  + +V  ++ G T L +A   +   V   +  RGA ++   + G
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 690  NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
              PL +A       +   L+  G               T LH A    +   +  L+  G
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHG 295

Query: 750  CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
              + +            + ++G +P+H+AA     + V+ LL++ A ++    +  TP+H
Sbjct: 296  APIQA------------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343

Query: 810  VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
            VA    H  + ++L+       N R   G TP   A   KN+     +L +   + + V 
Sbjct: 344  VAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVT 401

Query: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
              G   LHVA     +  V  L+   A+ N  V +    TPLH+A +AG   + + LL  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETPLHMAARAGHTEVAKYLLQN 459

Query: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
             AKVN   K  QT LH AA+     +  +LLEN  +       G+  LH+A   G +  +
Sbjct: 460  KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 990  RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049
              LL E          +G +PLH+  +YGK   A   +L LE    +P +    +G T L
Sbjct: 520  LALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLLE-RDAHP-NAAGKNGLTPL 573

Query: 1050 LLAYMKGNANLCRAIVRSG 1068
             +A    N ++ + ++  G
Sbjct: 574  HVAVHHNNLDIVKLLLPRG 592



 Score =  145 bits (366), Expect = 2e-34
 Identities = 134/532 (25%), Positives = 232/532 (43%), Gaps = 35/532 (6%)

Query: 550  AIAYNHPDVVSVILE--QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607
            ++ +   D  +  L   +  N   A ++L+   D +  +      L LA   G   +  +
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 608  LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
            LL     +  T   G T LH+A      +    L+ + A++N +++Q G T L +A +  
Sbjct: 64   LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQEN 122

Query: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
               VV  +   GA+ +V  E G  PL +AL    E++ + L+ +G       P       
Sbjct: 123  HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------ 176

Query: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
              LH A   ++  TA  L++     N P         +  ++ G TPLH+AA +      
Sbjct: 177  --LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGFTPLHIAAHYENLNVA 222

Query: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847
            Q LL  GA+VN     G TP+H+A    + ++++LL+      +  + +  LTP  CA  
Sbjct: 223  QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIETKTKDELTPLHCAAR 281

Query: 848  FKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDAS 906
              + + +E +L  + GA  Q   K G + +H+A Q   ++ V  L+   A ++    D  
Sbjct: 282  NGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-- 337

Query: 907  KLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDF 966
             LTPLH+A   G   + + LL  GAK N    +  T LH+A +++   +  +LL+ G   
Sbjct: 338  HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 967  AAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF 1026
             AV E+G   LH+A   G L  ++ LL +        N++ ++PLH+  + G    A   
Sbjct: 398  DAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
                       ++    D  T L  A   G+ N+ + ++ + A   +    G
Sbjct: 457  -----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503



 Score =  128 bits (321), Expect = 4e-29
 Identities = 104/397 (26%), Positives = 173/397 (43%), Gaps = 58/397 (14%)

Query: 732  RAIDENNEPTACFLIRSGCDVNSPRQPGANG------EG---------------EEEARD 770
            RA    N   A   +R+G D+N+  Q G NG      EG               E   + 
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 771  GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIH 830
            G T LH+AA  G +E V+ L+ +GANVNAQ  +G TP+++A    H  +++ L+ +   +
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GAN 136

Query: 831  LNVRDRQGLTPFACAM----------------------------TFKNNKSAEAILKRES 862
             NV    G TP A A+                               ++    A+L +  
Sbjct: 137  QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 863  GAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEII 922
               + +   G   LH+A    ++     L++  A+VN   Q+   +TPLH+A + G+ I+
Sbjct: 197  PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG--ITPLHIASRRGNVIM 254

Query: 923  VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            VR LL  GA++   TK   T LH AA+     I  +LL++G    A  +NG + +H+A  
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPD 1042
               L+ +R+LL +   + +   L   +PLH+    G    A +         G   +   
Sbjct: 315  GDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-----LDKGAKPNSRA 368

Query: 1043 ADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
             +G T L +A  K +  +   ++++GA +      G+
Sbjct: 369  LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  197 bits (502), Expect = 4e-50
 Identities = 221/824 (26%), Positives = 337/824 (40%), Gaps = 99/824 (12%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N  + NG   L LA       +   L+  +  ++   K G + LH     G       L
Sbjct: 38   INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97

Query: 309  IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +  GA VNA +     TPL++ A                ++ + LL+ GAN N+    G 
Sbjct: 98   VNYGANVNAQSQKGF-TPLYMAA-----------QENHLEVVKFLLENGANQNVATEDGF 145

Query: 369  TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV-------- 420
            TPL V++  G+E V + L+          ++     + L   HI   +D +         
Sbjct: 146  TPLAVALQQGHENVVAHLI----------NYGTKGKVRLPALHIAARNDDTRTAAVLLQN 195

Query: 421  NPFEDV-------PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAA 473
            +P  DV       P+     ++  + A  L+ RG+  +      G   L  A+  GN   
Sbjct: 196  DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQ-NGITPLHIASRRGNVIM 254

Query: 474  ALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAAS 533
               L   GA +  + K   TPLH A R+G   ++  LL  GA    +T+  L        
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-------- 306

Query: 534  LTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVL 593
                       +P+HMA   +H D V ++L+  A           I D +L      T L
Sbjct: 307  -----------SPIHMAAQGDHLDCVRLLLQYDAE----------IDDITLDHL---TPL 342

Query: 594  GLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRT 653
             +A   G H +A  LL  GA  N    +G T LH+A ++   +    LL+  A I+   T
Sbjct: 343  HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV-T 401

Query: 654  QDGETALQLA-IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
            + G T L +A     LP+V + +  RGA  +V + K   PL +A      ++A  L+++ 
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460

Query: 713  CDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQ 772
                          QT LH A    +      L+ +  + N     G             
Sbjct: 461  AKVNAKAKDD----QTPLHCAARIGHTNMVKLLLENNANPNLATTAG------------H 504

Query: 773  TPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLN 832
            TPLH+AA  G  ETV  LLE  A+      +G TP+HVA       + +LL+   D H N
Sbjct: 505  TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER-DAHPN 563

Query: 833  VRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLI 892
               + GLTP   A+   N    + +L R  G+       G   LH+A + + +E    L+
Sbjct: 564  AAGKNGLTPLHVAVHHNNLDIVKLLLPR-GGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 893  SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
                + N+  +    +TPLHLA Q G   +V  LL   A  N   K   T LHL AQ+  
Sbjct: 623  QYGGSANA--ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680

Query: 953  PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLH 1012
              +  VL+++GV   A    G   LH+A  +G +  ++ LL +   D  A    G SPLH
Sbjct: 681  VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLL-QHQADVNAKTKLGYSPLH 739

Query: 1013 ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKG 1056
               Q G  +   I  L L+   G   ++  +DG+T L +A   G
Sbjct: 740  QAAQQGHTD---IVTLLLK--NGASPNEVSSDGTTPLAIAKRLG 778



 Score =  186 bits (473), Expect = 9e-47
 Identities = 204/771 (26%), Positives = 315/771 (40%), Gaps = 115/771 (14%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           L      G+ AL +A     + +   LV++ A+V+   + G++ L+   Q   L    FL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 309 IKNGAFVNAAT------------LGAQETPLHLV-----------ALYSSKKH------- 338
           ++NGA  N AT             G +    HL+           AL+ + ++       
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 339 -------SADVMS-------------EMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
                  + DV+S             E   +A+ LL  GA+ N     G TPLH++   G
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250

Query: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITVSSD--------QSVNPFEDVPV 428
           N  +  +LL  +   +E K  +  T L  A +  H+ +S          Q+       P+
Sbjct: 251 N-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                 D       L+Q  +  D   T      L  AA  G+   A  L   GA  N R 
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEID-DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
             G TPLH AC+     +   LL+ GA+ +  TE  L                   TPLH
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL-------------------TPLH 409

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
           +A    H  +V  +L++ A+              ++ + + +T L +A   G   +A  L
Sbjct: 410 VASFMGHLPIVKNLLQRGASP-------------NVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 609 LGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQL 668
           L + A +N    D QT LH A +   +     LLE+ A+ N++ T  G T L +A R   
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGH 515

Query: 669 PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQT 728
              V A+  + A  +   +KG  PL +A       +A  L+    DA     G  G   T
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGL--T 571

Query: 729 LLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQ 788
            LH A+  NN      L+  G    SP  P  NG          TPLH+AA     E  +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRG---GSPHSPAWNG---------YTPLHIAAKQNQVEVAR 619

Query: 789 CLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTF 848
            LL++G + NA+  +G TP+H+A    H  ++ LL+S    + N+ ++ GLTP       
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS-KQANGNLGNKSGLTPLHLVAQE 678

Query: 849 KNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKL 908
            +   A+ ++K      +     G   LHVA    +I+ V FL+   A+VN++ +     
Sbjct: 679 GHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK--LGY 735

Query: 909 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
           +PLH A Q G   IV  LL  GA  NE++    T L +A +    ++  VL
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  152 bits (384), Expect = 2e-36
 Identities = 161/619 (26%), Positives = 257/619 (41%), Gaps = 58/619 (9%)

Query: 464  RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG--------- 514
            RAA +GN   AL    NG  +N  N+ G   LH A + G   +  ELL +          
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 515  ANPNLQTEEALPLPKEAASLTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANA 569
             N  L         +    L +   +V+ Q     TPL+MA   NH +VV  +LE  AN 
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 570  LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA 629
              AT +               T L +AL  G   + A L+  G      +      LH+A
Sbjct: 138  NVATED-------------GFTPLAVALQQGHENVVAHLINYGTKGKVRLP----ALHIA 180

Query: 630  IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
             +  D+++A  LL++  + +V  ++ G T L +A   +   V   +  RGA ++   + G
Sbjct: 181  ARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 690  NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
              PL +A       +   L+  G               T LH A    +   +  L+  G
Sbjct: 240  ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE----LTPLHCAARNGHVRISEILLDHG 295

Query: 750  CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
              + +            + ++G +P+H+AA     + V+ LL++ A ++    +  TP+H
Sbjct: 296  APIQA------------KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLH 343

Query: 810  VAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
            VA    H  + ++L+       N R   G TP   A   KN+     +L +   + + V 
Sbjct: 344  VAAHCGHHRVAKVLLDK-GAKPNSRALNGFTPLHIACK-KNHVRVMELLLKTGASIDAVT 401

Query: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
              G   LHVA     +  V  L+   A+ N  V +    TPLH+A +AG   + + LL  
Sbjct: 402  ESGLTPLHVASFMGHLPIVKNLLQRGASPN--VSNVKVETPLHMAARAGHTEVAKYLLQN 459

Query: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
             AKVN   K  QT LH AA+     +  +LLEN  +       G+  LH+A   G +  +
Sbjct: 460  KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 990  RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049
              LL E          +G +PLH+  +YGK   A   +L LE    +P +    +G T L
Sbjct: 520  LALL-EKEASQACMTKKGFTPLHVAAKYGKVRVA---ELLLE-RDAHP-NAAGKNGLTPL 573

Query: 1050 LLAYMKGNANLCRAIVRSG 1068
             +A    N ++ + ++  G
Sbjct: 574  HVAVHHNNLDIVKLLLPRG 592



 Score =  145 bits (366), Expect = 2e-34
 Identities = 134/532 (25%), Positives = 232/532 (43%), Gaps = 35/532 (6%)

Query: 550  AIAYNHPDVVSVILE--QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607
            ++ +   D  +  L   +  N   A ++L+   D +  +      L LA   G   +  +
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63

Query: 608  LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
            LL     +  T   G T LH+A      +    L+ + A++N +++Q G T L +A +  
Sbjct: 64   LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQEN 122

Query: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
               VV  +   GA+ +V  E G  PL +AL    E++ + L+ +G       P       
Sbjct: 123  HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------ 176

Query: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
              LH A   ++  TA  L++     N P         +  ++ G TPLH+AA +      
Sbjct: 177  --LHIAARNDDTRTAAVLLQ-----NDPNP-------DVLSKTGFTPLHIAAHYENLNVA 222

Query: 788  QCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMT 847
            Q LL  GA+VN     G TP+H+A    + ++++LL+      +  + +  LTP  CA  
Sbjct: 223  QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR-GAQIETKTKDELTPLHCAAR 281

Query: 848  FKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDAS 906
              + + +E +L  + GA  Q   K G + +H+A Q   ++ V  L+   A ++    D  
Sbjct: 282  NGHVRISEILL--DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD-- 337

Query: 907  KLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDF 966
             LTPLH+A   G   + + LL  GAK N    +  T LH+A +++   +  +LL+ G   
Sbjct: 338  HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI 397

Query: 967  AAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF 1026
             AV E+G   LH+A   G L  ++ LL +        N++ ++PLH+  + G    A   
Sbjct: 398  DAVTESGLTPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
                       ++    D  T L  A   G+ N+ + ++ + A   +    G
Sbjct: 457  -----LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503



 Score =  128 bits (321), Expect = 4e-29
 Identities = 104/397 (26%), Positives = 173/397 (43%), Gaps = 58/397 (14%)

Query: 732  RAIDENNEPTACFLIRSGCDVNSPRQPGANG------EG---------------EEEARD 770
            RA    N   A   +R+G D+N+  Q G NG      EG               E   + 
Sbjct: 18   RAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77

Query: 771  GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIH 830
            G T LH+AA  G +E V+ L+ +GANVNAQ  +G TP+++A    H  +++ L+ +   +
Sbjct: 78   GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN-GAN 136

Query: 831  LNVRDRQGLTPFACAM----------------------------TFKNNKSAEAILKRES 862
             NV    G TP A A+                               ++    A+L +  
Sbjct: 137  QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 863  GAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEII 922
               + +   G   LH+A    ++     L++  A+VN   Q+   +TPLH+A + G+ I+
Sbjct: 197  PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG--ITPLHIASRRGNVIM 254

Query: 923  VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            VR LL  GA++   TK   T LH AA+     I  +LL++G    A  +NG + +H+A  
Sbjct: 255  VRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPD 1042
               L+ +R+LL +   + +   L   +PLH+    G    A +         G   +   
Sbjct: 315  GDHLDCVRLLL-QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL-----LDKGAKPNSRA 368

Query: 1043 ADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
             +G T L +A  K +  +   ++++GA +      G+
Sbjct: 369  LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  166 bits (420), Expect = 1e-40
 Identities = 258/1012 (25%), Positives = 372/1012 (36%), Gaps = 201/1012 (19%)

Query: 162  VNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYP 221
            VN R+  + +QT   + A+     CAE +A     L   D S  SA              
Sbjct: 100  VNARD--KLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA-------------- 143

Query: 222  LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281
            LH A+     + V L L +  S     LN  D      L  A       +   LV+  AD
Sbjct: 144  LHHAVHSGHLETVNLLLNKGAS-----LNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198

Query: 282  VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSAD 341
            +   D+ G+ LLH     G +    +L++ GA ++        T LH +A Y  +     
Sbjct: 199  LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN-AFGNTALH-IACYLGQD---- 252

Query: 342  VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
                   +A  L+ AGAN N  + KG TPLHV+ ++ N  +  +LL     D+  +  EG
Sbjct: 253  ------AVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEG 306

Query: 402  STALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCL 461
             + L +A  H   +  Q                        LIQ GS  D  D   GN  
Sbjct: 307  KSPLHMAAIHGRFTRSQI-----------------------LIQNGSEIDCAD-KFGNTP 342

Query: 462  LQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG----ANP 517
            L  AA  G+E     L TNGA    R      PLH A   G ++   +LL  G       
Sbjct: 343  LHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVS 402

Query: 518  NLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQ 577
            +L  E  L    +  +  +L      +T LH A +  + + ++++L   A          
Sbjct: 403  SLSNEHVLSAGFDINTPDNLG-----RTCLHAAASGGNVECLNLLLSSGA---------- 447

Query: 578  IIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA-------- 629
               D   +D   +T L  A   G +  A  L+ +GA +N+    G + LH A        
Sbjct: 448  ---DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRR 504

Query: 630  ----------------IQRQDSKSALFLLEHQADINVS---RTQDGETALQLAI----RN 666
                            ++    K A F LE   D       R + G TA+  A     R 
Sbjct: 505  AEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQ 564

Query: 667  QLPLVVDAI--CTRGADMSVP-----------------------------DEKGNPPLWL 695
             L L+++    C    + ++P                             D KG   L+L
Sbjct: 565  NLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFL 624

Query: 696  ALANNLEDIASTLVRHGCDATC------WGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
            A      +    L  HG  A        W P         LH A    +  +   LI SG
Sbjct: 625  ATERGSTECVEVLTAHGASALIKERKRKWTP---------LHAAAASGHTDSLHLLIDSG 675

Query: 750  CDVNSPRQPGANGE----------------------GEEEARD--GQTPLHLAASWGLEE 785
               +      A G+                         +A D  G+T LH  A  G E+
Sbjct: 676  ERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735

Query: 786  TVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLL----VSHPDIHLNVRDRQGLTP 841
             +  LL+  A V  +D +GRTPIH+A +  H  +++ L    +S   +   V D  G +P
Sbjct: 736  CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGV-DYSGYSP 794

Query: 842  FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAV-QNSDIESVLFLISVHAN-VN 899
               A    +    E +L  E      ++      LH AV  N D  + + L ++ A  VN
Sbjct: 795  MHWASYTGHEDCLELLL--EHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVN 852

Query: 900  SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
            SR  DA   TPLH A  A +   +R LL   A+VN      +TAL  AA+         L
Sbjct: 853  SR--DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL 910

Query: 960  LENG-VDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVD---AEAFNLRGQSPLHILG 1015
            L  G  D   +DEN N ALHLA   G      ++L E T D     A N   Q PLHI  
Sbjct: 911  LYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE-TQDLGLINATNSALQMPLHIAA 969

Query: 1016 QYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067
            + G    A++    L    G  +   D +G T  L      +   C A++ S
Sbjct: 970  RNG---LASVVQALLS--HGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016



 Score =  161 bits (407), Expect = 4e-39
 Identities = 208/831 (25%), Positives = 332/831 (39%), Gaps = 109/831 (13%)

Query: 221  PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
            PLH+A     E V+ L L          +N  D      L +A + R    A  L    +
Sbjct: 77   PLHRAAASRNEKVLGLLLAHS-----ADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131

Query: 281  DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
             +++ D+SG S LH  +  G L     L+  GA +N      ++ PLH  A         
Sbjct: 132  SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ-PLHWAAFLGH----- 185

Query: 341  DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
                   ++ + L+  GA+   +D KG   LH +  +G   V   LL+    +++  +  
Sbjct: 186  ------LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGA-EIDEPNAF 238

Query: 401  GSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNC 460
            G+TAL +A                           +++ A  L+  G++ + P+   G  
Sbjct: 239  GNTALHIACY-----------------------LGQDAVAIELVNAGANVNQPNDK-GFT 274

Query: 461  LLQRAAGAGNEAAAL-FLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNL 519
             L  AA + N A  L  L  NGA VN+++K G++PLH A  HG    +  L+Q G     
Sbjct: 275  PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNG----- 329

Query: 520  QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKAN----ALHATNN 575
                         S    AD     TPLH+A  Y H  ++S ++   A+     +H    
Sbjct: 330  -------------SEIDCADKFG-NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFP 375

Query: 576  LQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ-LLGSGAAINDTMSDGQTLLHMAIQRQD 634
            L +   F   D   + +    L++ + +++ + +L +G  IN   + G+T LH A    +
Sbjct: 376  LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435

Query: 635  SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
             +    LL   AD+   R + G T L  A  N        + T GA ++  D KG  PL 
Sbjct: 436  VECLNLLLSSGADLR-RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494

Query: 695  LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 754
             A A++    A        DA    P             + E+    A F +    D   
Sbjct: 495  YAAASDTYRRAEPHTPSSHDAEEDEP-------------LKESRRKEAFFCLEFLLD--- 538

Query: 755  PRQPGANG-EGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGR---TPIHV 810
                  NG +     R G T +H AA++G  + ++ LLE   N   +D E     +P+H+
Sbjct: 539  ------NGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHL 591

Query: 811  AISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN 870
            A  + H   ++ L +   ++L+VRD +G T    A    + +  E +     GA+  +  
Sbjct: 592  AAYNGHCEALKTL-AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH--GASALIKE 648

Query: 871  KGRNF--LHVAVQNSDIESVLFLISVHANVN-SRVQDASKLTPLHLAVQAGSEIIVRNLL 927
            + R +  LH A  +   +S+  LI      + + V DA   TPL LA+  G    V  LL
Sbjct: 649  RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708

Query: 928  LAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLN 987
              G+  +      +TALH  A        + LL++       D  G   +HLA   G   
Sbjct: 709  EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768

Query: 988  NIRVLLTEC----TVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMP 1034
             +R LL        +DA   +  G SP+H     G E+     +L LE  P
Sbjct: 769  VLRTLLQAALSTDPLDA-GVDYSGYSPMHWASYTGHEDC---LELLLEHSP 815



 Score =  139 bits (351), Expect = 1e-32
 Identities = 199/821 (24%), Positives = 327/821 (39%), Gaps = 155/821 (18%)

Query: 342  VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
            + S   +   +LL    N N+ D + RTPLH +   G+  +  QLL     ++  KD   
Sbjct: 16   IFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPIL-QLLLMSGANVNAKD--- 71

Query: 402  STALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTAT---- 457
               LWL   H   +S       + + ++   S D N+   +L Q   H  A + AT    
Sbjct: 72   --TLWLTPLHRAAASRNE----KVLGLLLAHSADVNA-RDKLWQTPLHVAAANRATKCAE 124

Query: 458  ---------------GNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502
                           G   L  A  +G+      L   GA +N  +K    PLH A   G
Sbjct: 125  ALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184

Query: 503  LANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562
               +   L+ +GA+   +  +   L                   LH A A    +VV  +
Sbjct: 185  HLEVLKLLVARGADLGCKDRKGYGL-------------------LHTAAASGQIEVVKYL 225

Query: 563  LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG 622
            L   A             +    ++   T L +A + G   +A +L+ +GA +N     G
Sbjct: 226  LRMGA-------------EIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272

Query: 623  QTLLHMAIQRQDSKSAL-FLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGAD 681
             T LH+A    +    L  L+ + AD+N  ++++G++ L +A  +        +   G++
Sbjct: 273  FTPLHVAAVSTNGALCLELLVNNGADVNY-QSKEGKSPLHMAAIHGRFTRSQILIQNGSE 331

Query: 682  MSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP------------GPGGCLQTL 729
            +   D+ GN PL +A     E + STL+ +G D    G             G   C + L
Sbjct: 332  IDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKL 391

Query: 730  LHR------AIDENNEPTACFLIRSGCDVNSPRQPG-------ANGEGEE---------- 766
            L            +NE     ++ +G D+N+P   G       A+G   E          
Sbjct: 392  LSSGQLYSIVSSLSNE----HVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGA 447

Query: 767  --EARD--GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS-------- 814
                RD  G+TPLH AA+ G  +    L+  GA VN  D +G +P+H A +S        
Sbjct: 448  DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEP 507

Query: 815  --------------------QHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSA 854
                                +    ++ L+ +     ++RDRQG T    A  + N ++ 
Sbjct: 508  HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDN-GADPSLRDRQGYTAVHYAAAYGNRQNL 566

Query: 855  EAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHL 913
            E +L+      E V++    + LH+A  N   E++  L     N++  V+D    T L L
Sbjct: 567  ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD--VRDHKGRTALFL 624

Query: 914  AVQAGSEIIVRNLLLAGAK-VNELTKHRQTALHLAAQQDLPTICSVLLENG--VDFAAV- 969
            A + GS   V  L   GA  + +  K + T LH AA         +L+++G   D   V 
Sbjct: 625  ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVM 684

Query: 970  DENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIF--- 1026
            D  G   L LA+M+G ++ + +LL + +  A+A +LRG++ LH     G E+  A     
Sbjct: 685  DAYGQTPLMLAIMNGHVDCVHLLLEKGST-ADAADLRGRTALHRGAVTGCEDCLAALLDH 743

Query: 1027 DLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067
            D F+ C         D  G T + LA   G+  + R ++++
Sbjct: 744  DAFVLCR--------DFKGRTPIHLASACGHTAVLRTLLQA 776



 Score =  136 bits (342), Expect = 1e-31
 Identities = 157/596 (26%), Positives = 246/596 (41%), Gaps = 71/596 (11%)

Query: 529  KEAASLTSLADSVHL-----QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 583
            +E  SL S  +++++     +TPLH A       ++ ++L   AN ++A + L + P   
Sbjct: 22   EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGAN-VNAKDTLWLTPLHR 80

Query: 584  LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 643
               SR++ VLGL            LL   A +N      QT LH+A   + +K A  L  
Sbjct: 81   AAASRNEKVLGL------------LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128

Query: 644  HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPL-WLALANNLE 702
              + +NV+  + G +AL  A+ +     V+ +  +GA ++V D+K   PL W A   +LE
Sbjct: 129  LLSSLNVA-DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187

Query: 703  DIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANG 762
             +   LV  G D  C      G    LLH A          +L+R G +++ P       
Sbjct: 188  -VLKLLVARGADLGCKDRKGYG----LLHTAAASGQIEVVKYLLRMGAEIDEPNA----- 237

Query: 763  EGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQL 822
                    G T LH+A   G +     L+  GANVN  + +G TP+HVA  S +G +   
Sbjct: 238  -------FGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLE 290

Query: 823  LVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQN 882
            L+ +    +N + ++G +P   A       +   IL +     +  D  G   LHVA + 
Sbjct: 291  LLVNNGADVNYQSKEGKSPLHMA-AIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349

Query: 883  SDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG------------------SEIIVR 924
                 +  L++  A+   R      + PLHLAV  G                  S +   
Sbjct: 350  GHELLISTLMTNGADTARR--GIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNE 407

Query: 925  NLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 984
            ++L AG  +N      +T LH AA        ++LL +G D    D+ G   LH A  +G
Sbjct: 408  HVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467

Query: 985  RLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDAD 1044
                   L+T      EA + +G SPLH          AA  D +    P  P    DA+
Sbjct: 468  SYQCAVTLVTAGAGVNEA-DCKGCSPLHY---------AAASDTYRRAEPHTP-SSHDAE 516

Query: 1045 GSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVA--TKQLLFRLLDM 1098
                L  +  K        ++ +GA   + + QG    +Y  A   +Q L  LL+M
Sbjct: 517  EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM 572



 Score =  118 bits (296), Expect = 3e-26
 Identities = 173/688 (25%), Positives = 272/688 (39%), Gaps = 96/688 (13%)

Query: 443  LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA---- 498
            L+  G++ +A DT     L  RAA + NE     L  + A VN R+K  +TPLH A    
Sbjct: 60   LLMSGANVNAKDTLWLTPL-HRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118

Query: 499  ---CRHGLANLTAELLQQGANPNLQTEEALP---------LPKEAASLTSLADSVHLQTP 546
               C   LA L + L     +       A+          L  + ASL ++ D    Q P
Sbjct: 119  ATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL-NVCDKKERQ-P 176

Query: 547  LHMAIAYNHPDVVSVILEQKANA----------LH---ATNNLQIIP-------DFSLKD 586
            LH A    H +V+ +++ + A+           LH   A+  ++++        +    +
Sbjct: 177  LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN 236

Query: 587  SRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQ- 645
            +   T L +A + G   +A +L+ +GA +N     G T LH+A    +    L LL +  
Sbjct: 237  AFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNG 296

Query: 646  ADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIA 705
            AD+N  ++++G++ L +A  +        +   G+++   D+ GN PL +A     E + 
Sbjct: 297  ADVNY-QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLI 355

Query: 706  STLVRHGCDATCWGP------------GPGGCLQTLLHRA------IDENNEPTACFLIR 747
            STL+ +G D    G             G   C + LL            +NE     ++ 
Sbjct: 356  STLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNE----HVLS 411

Query: 748  SGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTP 807
            +G D+N+P   G            +T LH AAS G  E +  LL  GA++  +D  GRTP
Sbjct: 412  AGFDINTPDNLG------------RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459

Query: 808  IHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQ 867
            +H A ++        LV+     +N  D +G +P   A      + AE        A E 
Sbjct: 460  LHYAAANGSYQCAVTLVT-AGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEED 518

Query: 868  VDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNL- 926
               K         +      + FL+   A+ + R  D    T +H A   G+    +NL 
Sbjct: 519  EPLKESR------RKEAFFCLEFLLDNGADPSLR--DRQGYTAVHYAAAYGNR---QNLE 567

Query: 927  LLAGAKVNELTKHRQTA----LHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            LL     N L     T     LHLAA          L E  V+    D  G  AL LA  
Sbjct: 568  LLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATE 627

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPL-DKP 1041
             G    + VL             R  +PLH     G  ++     L ++      + D  
Sbjct: 628  RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDS---LHLLIDSGERADITDVM 684

Query: 1042 DADGSTVLLLAYMKGNANLCRAIVRSGA 1069
            DA G T L+LA M G+ +    ++  G+
Sbjct: 685  DAYGQTPLMLAIMNGHVDCVHLLLEKGS 712



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 45/164 (27%), Positives = 64/164 (39%), Gaps = 6/164 (3%)

Query: 910  PLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAV 969
            PL  A+ +     VR+LL     +N L + R+T LH AA      I  +LL +G +  A 
Sbjct: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 970  DENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLF 1029
            D      LH A    R   +  LL   + D  A +   Q+PLH+         A      
Sbjct: 71   DTLWLTPLHRAAA-SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129

Query: 1030 LECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGV 1073
            L       L+  D  G + L  A   G+      ++  GA L V
Sbjct: 130  LS-----SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV 168


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  160 bits (406), Expect = 5e-39
 Identities = 222/911 (24%), Positives = 358/911 (39%), Gaps = 144/911 (15%)

Query: 216  SKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTL 275
            SK   PLH+A+    E+ V + L     +    +N  D N    L +A + +    A  L
Sbjct: 72   SKWLTPLHRAVASCSEEAVQVLL-----KHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 276  VSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSS 335
            V   ++V++ D++G + LH     G       L+  GA +NA     +            
Sbjct: 127  VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRA---------- 176

Query: 336  KKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLE 395
              H A  M  + ++ + L+  GA    +D K  TPLH +  +G   V   LL    +D+ 
Sbjct: 177  -IHWAAYMGHI-EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL-GVDMN 233

Query: 396  LKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDT 455
              +  G+T L     H+   + Q V       VVN            LI  G+  +  + 
Sbjct: 234  EPNAYGNTPL-----HVACYNGQDV-------VVN-----------ELIDCGAIVNQKNE 270

Query: 456  ATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGA 515
                 L   AA          L  NGA VN ++K G+TPLH    HG  + +  ++Q GA
Sbjct: 271  KGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGA 330

Query: 516  NPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNN 575
              + + +                      TPLH+A  Y H  +++ ++   A        
Sbjct: 331  VIDCEDKNG-------------------NTPLHIAARYGHELLINTLITSGA-------- 363

Query: 576  LQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDS 635
                 D + +       L LA  +G      +LL SG  I+     G+T LH A    + 
Sbjct: 364  -----DTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418

Query: 636  KSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWL 695
            +    LL   AD N  + + G + L  A  N     + A+   GA ++  DE+G  PL  
Sbjct: 419  ECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHY 477

Query: 696  ALANN---------LEDIASTLVR--HGCDATCWGPGPGG--CLQTLLHRAIDENNEPTA 742
            A  ++         L + A+  +R   G +A  +    G   CLQ +       +  P  
Sbjct: 478  AATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI------ASETPLD 531

Query: 743  CFLIRSGCDVNSPRQPGAN--------GEGEEEARD---------------GQTPLHLAA 779
              +  SG D+ S     A           G  +A +               G+TPL LAA
Sbjct: 532  VLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAA 591

Query: 780  SWGLEETVQCLLEFGANVNAQD-AEGRTPIHVAISSQHGVIIQLLV--SHPDIHLNVRDR 836
              G  E V  L+  GA++  +D    RTPIH A ++ H   ++LL+  + P   ++++D 
Sbjct: 592  FKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG 651

Query: 837  QGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHA 896
             G TP   ++   +     ++L + +   +  D  GR  LH        E V  L+   A
Sbjct: 652  NGQTPLMLSVLNGHTDCVYSLLNKGAN-VDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710

Query: 897  NVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN----ELTKHRQTALHLAAQQDL 952
                 ++D+   TP+HL+   G   ++  LL + A ++        H  TALH A     
Sbjct: 711  --KCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGH 768

Query: 953  PTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVD-AEAFNLRGQSPL 1011
             T   +LLE  V F   + N  + LH AV++       +L+         A + +G++PL
Sbjct: 769  ETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPL 827

Query: 1012 HILGQYGKENAAAIFDLFLECMP-----GYPLDKPDADGSTVLLLAYMKGNANLCRAIVR 1066
            H          AA F   +EC+         ++  D+ G T L++A   G  N    +V 
Sbjct: 828  H----------AAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877

Query: 1067 S-GARLGVNNN 1076
            S  A L + +N
Sbjct: 878  SASAELTLQDN 888



 Score =  160 bits (406), Expect = 5e-39
 Identities = 208/827 (25%), Positives = 324/827 (39%), Gaps = 137/827 (16%)

Query: 215 KSKTEY-PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 273
           K K  Y PLH A       VV  YL+++   +    NE +  G+  L +A     + +  
Sbjct: 202 KDKKSYTPLHAAASSGMISVV-KYLLDLGVDM----NEPNAYGNTPLHVACYNGQDVVVN 256

Query: 274 TLVSHKADVDMVDKSGWSLLH-KGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVAL 332
            L+   A V+  ++ G++ LH              L+ NGA VN  +   + TPLH+ AL
Sbjct: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTAL 315

Query: 333 YSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQL 392
           +     S           + ++Q+GA  + +D  G TPLH++   G+E + + L+     
Sbjct: 316 HGRFSRS-----------QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT-SGA 363

Query: 393 DLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDA 452
           D   +   G   L LA          +++ F D                +L+  G   D 
Sbjct: 364 DTAKRGIHGMFPLHLA----------ALSGFSDC-------------CRKLLSSGFDIDT 400

Query: 453 PDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ 512
           PD     CL   AAG   E   L L T GA  N ++K+G +PLH A  +        L+ 
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNT-GADFNKKDKFGRSPLHYAAANCNYQCLFALVG 459

Query: 513 QGANPN-LQTEEALPLPKEAASLTSLADSVHL--------------QTPLHMAIAYNHPD 557
            GA+ N L      PL   A S T      +L                 +H + AY H  
Sbjct: 460 SGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRL 519

Query: 558 VVSVIL-EQKANALHATNNLQIIPDFSLKDSRDQ-TVLGLALWTGMHTIAAQLLGSGAAI 615
            + +I  E   + L  T+   ++ D    D+R   + L LA + G H     L+ S   +
Sbjct: 520 CLQLIASETPLDVLMETSGTDMLSD---SDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576

Query: 616 NDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ----LPLV 671
           +   S G+T L +A  +   +    L+   A I V       T +  A  N     L L+
Sbjct: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636

Query: 672 VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATC---WGPGPGGCLQT 728
           +     + A + + D  G  PL L++ N   D   +L+  G +      WG       +T
Sbjct: 637 IGNAEPQNA-VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG-------RT 688

Query: 729 LLHRAIDENNEPTACFLIRSG--CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEET 786
            LHR     +E     L++ G  C +   R              G+TP+HL+A+ G    
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRDSR--------------GRTPIHLSAACGHIGV 734

Query: 787 VQCLLEFGANVNAQ----DAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPF 842
           +  LL+  A+++A     D  G T +H A  + H   ++LL+          +    +P 
Sbjct: 735 LGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKT--EGNAFSPL 792

Query: 843 ACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNS- 900
            CA+   N  +AE ++     +     D+KGR  LH A     +E +  L+S +A VNS 
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSV 852

Query: 901 -------------------------------RVQDASKLTPLHLAVQAGSE---IIVRNL 926
                                           +QD SK T LHLA   G E   +++   
Sbjct: 853 DSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912

Query: 927 LLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENG 973
           +     +N      QT LH+AA+  L  +   LL  G    AVDENG
Sbjct: 913 ITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959



 Score =  152 bits (383), Expect = 2e-36
 Identities = 143/562 (25%), Positives = 233/562 (41%), Gaps = 42/562 (7%)

Query: 544  QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHT 603
            Q  L  AI    PD V  ++ +K              D + +D+  +T L  A + G   
Sbjct: 9    QPSLVQAIFNGDPDEVRALIFKKE-------------DVNFQDNEKRTPLHAAAYLGDAE 55

Query: 604  IAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLA 663
            I   L+ SGA +N   S   T LH A+     ++   LL+H AD+N +R ++ +T L +A
Sbjct: 56   IIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIA 114

Query: 664  IRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPG 723
              N+     +A+    ++++V D  G   L  A  +   ++   L+  G +   +     
Sbjct: 115  AANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD- 173

Query: 724  GCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGL 783
               +  +H A    +      L+  G +V              + +   TPLH AAS G+
Sbjct: 174  ---RRAIHWAAYMGHIEVVKLLVSHGAEVTC------------KDKKSYTPLHAAASSGM 218

Query: 784  EETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFA 843
               V+ LL+ G ++N  +A G TP+HVA  +   V++  L+    I +N ++ +G TP  
Sbjct: 219  ISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI-VNQKNEKGFTPLH 277

Query: 844  CAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQ 903
             A    +      +L             G+  LH+   +        +I   A ++   +
Sbjct: 278  FAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDC--E 335

Query: 904  DASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENG 963
            D +  TPLH+A + G E+++  L+ +GA   +   H    LHLAA       C  LL +G
Sbjct: 336  DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG 395

Query: 964  VDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAA 1023
             D    D+ G   LH A   G L  + +LL     D    +  G+SPLH    Y   N  
Sbjct: 396  FDIDTPDDFGRTCLHAAAAGGNLECLNLLL-NTGADFNKKDKFGRSPLH----YAAAN-C 449

Query: 1024 AIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLC-RAIVRSGARLGVNNNQGVNIF 1082
                LF     G  ++  D  G T L  A        C   ++R+ A  G+ + QG N  
Sbjct: 450  NYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAV 509

Query: 1083 NYQVATKQLLFRLLDMLSKEPP 1104
            +Y  A    L   L +++ E P
Sbjct: 510  HYSAAYGHRL--CLQLIASETP 529



 Score =  145 bits (365), Expect = 3e-34
 Identities = 192/784 (24%), Positives = 306/784 (39%), Gaps = 131/784 (16%)

Query: 323  QETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYV 382
            + TPLH  A               A+I E L+ +GA  N +DSK  TPLH ++ + +E  
Sbjct: 41   KRTPLHAAAYLGD-----------AEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89

Query: 383  FSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPF-EDVPV---VNGTSFDENS 438
               LL+    D+  +D    T L +A  +  V   +++ P   +V V      T+    +
Sbjct: 90   VQVLLK-HSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148

Query: 439  FAAR------LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGE 492
            F+        L+ RG++ +A D      +   AA  G+      L ++GA V  ++K   
Sbjct: 149  FSGHGEMVKLLLSRGANINAFDKKDRRAI-HWAAYMGHIEVVKLLVSHGAEVTCKDKKSY 207

Query: 493  TPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIA 552
            TPLH A   G+ ++   LL  G + N                     + +  TPLH+A  
Sbjct: 208  TPLHAAASSGMISVVKYLLDLGVDMN-------------------EPNAYGNTPLHVA-C 247

Query: 553  YNHPDVVSVILEQKANALHATNNLQIIP-DFSLKDSRDQTVLGLALWTGMHTIAAQLLGS 611
            YN  DVV   L      ++  N     P  F+   +     L L            L+G+
Sbjct: 248  YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLEL------------LVGN 295

Query: 612  GAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLV 671
            GA +N    DG+T LHM         +  +++  A I+    ++G T L +A R    L+
Sbjct: 296  GADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGHELL 354

Query: 672  VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLH 731
            ++ + T GAD +     G  PL LA  +   D    L+  G D       P    +T LH
Sbjct: 355  INTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT----PDDFGRTCLH 410

Query: 732  RAIDENNEPTACFLIRSGCDVNSP----RQP-----------------GANGEGEEEARD 770
             A    N      L+ +G D N      R P                 G+     +    
Sbjct: 411  AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470

Query: 771  GQTPLHLAASWGLE-ETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDI 829
            G TPLH AA+   + + ++ LL   AN   +D +G   +H + +  H + +QL+ S   +
Sbjct: 471  GCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPL 530

Query: 830  HLNVR-----------DRQGLTPFACAMTFKNNKSAEAILK-------RES--------- 862
             + +            +R  ++P   A    ++++ E +++       R S         
Sbjct: 531  DVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLA 590

Query: 863  ---GAAEQVD---NKGRNFL-----------HVAVQNSDIESVLFLISVHANVNS-RVQD 904
               G  E VD   N+G + L           H A  N   E +  LI      N+  +QD
Sbjct: 591  AFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQD 650

Query: 905  ASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGV 964
             +  TPL L+V  G    V +LL  GA V+   K  +TALH  A          LL++G 
Sbjct: 651  GNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710

Query: 965  DFAAVDENGNNALHLAVMHGRLNNIRVLL-TECTVDAE--AFNLRGQSPLHILGQYGKEN 1021
                 D  G   +HL+   G +  +  LL +  ++DA     +  G + LH     G E 
Sbjct: 711  KCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHET 770

Query: 1022 AAAI 1025
               +
Sbjct: 771  CVEL 774



 Score =  134 bits (336), Expect = 7e-31
 Identities = 191/767 (24%), Positives = 319/767 (41%), Gaps = 88/767 (11%)

Query: 352  ALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ- 410
            AL+    + N QD++ RTPLH +   G+  +  +LL      +  KD +  T L  AV  
Sbjct: 26   ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEII-ELLILSGARVNAKDSKWLTPLHRAVAS 84

Query: 411  ------HITVSSDQSVNPFE---DVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCL 461
                   + +     VN  +     P+    +      A  L+   S+ +  D A G   
Sbjct: 85   CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA-GRTA 143

Query: 462  LQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQT 521
            L  AA +G+      L + GA++N  +K     +H A   G   +   L+  GA    + 
Sbjct: 144  LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203

Query: 522  EEA-LPLPKEAAS-----LTSLAD--------SVHLQTPLHMAIAYNHPDVVSVILEQKA 567
            +++  PL   A+S     +  L D        + +  TPLH+A  YN  DVV   L    
Sbjct: 204  KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA-CYNGQDVVVNELIDCG 262

Query: 568  NALHATNNLQIIP-DFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLL 626
              ++  N     P  F+   +     L L            L+G+GA +N    DG+T L
Sbjct: 263  AIVNQKNEKGFTPLHFAAASTHGALCLEL------------LVGNGADVNMKSKDGKTPL 310

Query: 627  HMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPD 686
            HM         +  +++  A I+    ++G T L +A R    L+++ + T GAD +   
Sbjct: 311  HMTALHGRFSRSQTIIQSGAVID-CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369

Query: 687  EKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLI 746
              G  PL LA  +   D    L+  G D       P    +T LH A    N      L+
Sbjct: 370  IHGMFPLHLAALSGFSDCCRKLLSSGFDIDT----PDDFGRTCLHAAAAGGNLECLNLLL 425

Query: 747  RSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRT 806
             +G D N            ++ + G++PLH AA+    + +  L+  GA+VN  D  G T
Sbjct: 426  NTGADFN------------KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT 473

Query: 807  PIHVAISSQ-HGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAI-------- 857
            P+H A +S   G  ++ L+ + D +  +RD+QG      +  + +    + I        
Sbjct: 474  PLHYAATSDTDGKCLEYLLRN-DANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532

Query: 858  LKRESGAAEQVDNKGR---NFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLA 914
            L   SG     D+  R   + LH+A  +   +++  L  V + ++  V+++S  TPL LA
Sbjct: 533  LMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVL--VQSLLDLDVRNSSGRTPLDLA 590

Query: 915  VQAGSEIIVRNLLLAGAKVNELTKH---RQTALHLAAQQDLPTICSVLLENGVDFAAV-- 969
               G    V  L+  GA +  L K    ++T +H AA         +L+ N     AV  
Sbjct: 591  AFKGHVECVDVLINQGASI--LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDI 648

Query: 970  -DENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAA-AIFD 1027
             D NG   L L+V++G  + +  LL +   + +A +  G++ LH     G E    A+  
Sbjct: 649  QDGNGQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQ 707

Query: 1028 LFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVN 1074
               +C+        D+ G T + L+   G+  +  A+++S A +  N
Sbjct: 708  HGAKCL------LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 139/577 (24%), Positives = 217/577 (37%), Gaps = 65/577 (11%)

Query: 250 NEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRG-DLFAATFL 308
           N+ D  G   L  A +         LV   A V+ +D+ G + LH       D     +L
Sbjct: 432 NKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491

Query: 309 IKNGAFVNAATLGAQE-TPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
           ++N A  N      Q    +H  A Y  +     + SE     + L++      + DS  
Sbjct: 492 LRNDA--NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETP--LDVLMETSGTDMLSDSDN 547

Query: 368 R---TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA-----VQHITVSSDQS 419
           R   +PLH++   G+      L+Q   LDL++++  G T L LA     V+ + V  +Q 
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQ-SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQG 606

Query: 420 VNPF------EDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGN--CLLQRAAGAGNE 471
            +        +  P+    +   +     LI      +A D   GN    L  +   G+ 
Sbjct: 607 ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHT 666

Query: 472 AAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEA 531
                L   GA+V+ ++KWG T LH     G       LLQ GA   L+           
Sbjct: 667 DCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG------- 719

Query: 532 ASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQT 591
                       +TP+H++ A  H  V+  +L+  A+         +  + +  D+   T
Sbjct: 720 ------------RTPIHLSAACGHIGVLGALLQSAAS---------MDANPATADNHGYT 758

Query: 592 VLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVS 651
            L  A + G H    +LL        T  +  + LH A+   +  +A  L++      V+
Sbjct: 759 ALHWACYNG-HETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVN 817

Query: 652 RTQD-GETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVR 710
            T   G T L  A        +  + +  A ++  D  G  PL +A  N   +    LV 
Sbjct: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877

Query: 711 HGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARD 770
               A+           T LH A  + +E +A  ++    D N      A          
Sbjct: 878 ---SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAAL-------- 926

Query: 771 GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTP 807
            QTPLH+AA  GL   VQ LL  GA+V A D  G TP
Sbjct: 927 -QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 154/644 (23%), Positives = 241/644 (37%), Gaps = 100/644 (15%)

Query: 255 NGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAF 314
           +G   L LA           L+S   D+D  D  G + LH     G+L     L+  GA 
Sbjct: 371 HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD 430

Query: 315 VNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
            N      + +PLH  A   +            Q   AL+ +GA+ N  D +G TPLH +
Sbjct: 431 FNKKDKFGR-SPLHYAAANCNY-----------QCLFALVGSGASVNDLDERGCTPLHYA 478

Query: 375 IMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH---ITVSSDQSVNPFEDVPVVNG 431
             +  +    + L     +  ++D +G  A+  +  +   + +    S  P + +   +G
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG 538

Query: 432 TSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWG 491
           T    +S               D       L  AA  G+  A   L  +   ++ RN  G
Sbjct: 539 TDMLSDS---------------DNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSG 583

Query: 492 ETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHL-------- 543
            TPL  A   G       L+ QGA+  ++       P  AA+    ++ + L        
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQ 643

Query: 544 ----------QTPLHMAIAYNHPDVVSVILEQKAN----------ALH---ATNNLQIIP 580
                     QTPL +++   H D V  +L + AN          ALH    T + + + 
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVD 703

Query: 581 DFS-------LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAI--NDTMSD--GQTLLHMA 629
                     L+DSR +T + L+   G   +   LL S A++  N   +D  G T LH A
Sbjct: 704 ALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWA 763

Query: 630 IQRQDSKSALFLLEHQADINVSRTQDGE--TALQLAIRNQLPLVVDAIC-TRGADM-SVP 685
                      LLE +    V +  +G   + L  A+ N      + +  T GA + +  
Sbjct: 764 CYNGHETCVELLLEQE----VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAT 819

Query: 686 DEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFL 745
           D KG  PL  A   +  +    L+ H               +T L  A +     T   L
Sbjct: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVN----SVDSTGKTPLMMAAENGQTNTVEML 875

Query: 746 IRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGAN---VNAQDA 802
           + S           A+ E   +     T LHLA S G E +   +LE   +   +NA +A
Sbjct: 876 VSS-----------ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924

Query: 803 EGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP-FACA 845
             +TP+HVA  +   +++Q L+      L V D  G TP  ACA
Sbjct: 925 ALQTPLHVAARNGLTMVVQELLGKGASVLAV-DENGYTPALACA 967



 Score = 73.9 bits (180), Expect = 8e-13
 Identities = 97/377 (25%), Positives = 153/377 (40%), Gaps = 59/377 (15%)

Query: 282 VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSAD 341
           VD+ D +G + L   +  G       L+  GA V+A     + T LH  A+   +     
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR-TALHRGAVTGHE----- 699

Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ-CKQLDLE--LKD 398
                 +  +ALLQ GA   ++DS+GRTP+H+S   G+  V   LLQ    +D      D
Sbjct: 700 ------ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATAD 753

Query: 399 HEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSF--------DENSFAARLI---QRG 447
           + G TAL  A  +   +  + +   E      G +F        ++N  AA ++      
Sbjct: 754 NHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGA 813

Query: 448 SHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLT 507
           S  +A D+  G   L  AA   +      L ++ A VN  +  G+TPL  A  +G  N T
Sbjct: 814 SIVNATDSK-GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN-T 871

Query: 508 AELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQ-- 565
            E+L   A+  L  ++                     T LH+A +  H     +ILE+  
Sbjct: 872 VEMLVSSASAELTLQDNSK-----------------NTALHLACSKGHETSALLILEKIT 914

Query: 566 KANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTL 625
             N ++ATN            +  QT L +A   G+  +  +LLG GA++     +G T 
Sbjct: 915 DRNLINATN------------AALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962

Query: 626 LHMAIQRQDSKSALFLL 642
                  +D    L L+
Sbjct: 963 ALACAPNKDVADCLALI 979



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 86/382 (22%), Positives = 143/382 (37%), Gaps = 56/382 (14%)

Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
           P+H A      + + L +   + Q    ++  D NG   L L++         +L++  A
Sbjct: 620 PIHAAATNGHSECLRLLIGNAEPQ--NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677

Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA 340
           +VD  DK G + LH+G   G       L+++GA         + TP+HL A         
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-TPIHLSAACGH----I 732

Query: 341 DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ------------ 388
            V+  + Q A ++    ANP   D+ G T LH +   G+E     LL+            
Sbjct: 733 GVLGALLQSAASM---DANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF 789

Query: 389 ----CKQLD-----------------LELKDHEGSTALWLAV-------QHITVSSDQSV 420
               C  ++                 +   D +G T L  A          + +S +  V
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849

Query: 421 NPFEDV---PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFL 477
           N  +     P++      + +    L+   S        + N  L  A   G+E +AL +
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909

Query: 478 A---TNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASL 534
               T+   +N  N   +TPLH A R+GL  +  ELL +GA+     E         A  
Sbjct: 910 LEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN 969

Query: 535 TSLADSVHLQTPLHMAIAYNHP 556
             +AD + L     M ++ + P
Sbjct: 970 KDVADCLALILATMMPVSSSSP 991


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  152 bits (385), Expect = 1e-36
 Identities = 224/911 (24%), Positives = 368/911 (40%), Gaps = 121/911 (13%)

Query: 214  IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 273
            + S+   PLH A  +   +++ L ++        ++N  D+     L  A++ R E    
Sbjct: 12   LDSEKRTPLHVAAFLGDAEIIELLILS-----GARVNAKDNMWLTPLHRAVASRSEEAVQ 66

Query: 274  TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 333
             L+ H ADV+  DK+  + LH       +  A  +I   + VN +  G + T LH  AL 
Sbjct: 67   VLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGR-TALHHAALN 125

Query: 334  SSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLD 393
                          ++   LL  GAN N  D K R  LH +   G+  V + L+     +
Sbjct: 126  GH-----------VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN-HGAE 173

Query: 394  LELKDHEGSTALWLA--------VQHIT---VSSDQSVNPFEDVPVVNGTSFDENSFAAR 442
            +  KD +G T L  A        V+H+    V  D+ +N + +  +       +++    
Sbjct: 174  VTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDE-INVYGNTALHIACYNGQDAVVNE 232

Query: 443  LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAAL-FLATNGAHVNHRNKWGETPLHTACRH 501
            LI  G++ + P+   G   L  AA + + A  L  L  NGA VN ++K G++PLH    H
Sbjct: 233  LIDYGANVNQPNN-NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVH 291

Query: 502  GLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSV 561
            G    +  L+Q G   +   ++                     TPLH+A  Y H  +++ 
Sbjct: 292  GRFTRSQTLIQNGGEIDCVDKDG-------------------NTPLHVAARYGHELLINT 332

Query: 562  ILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSD 621
            +    A+    T    I   F L          LA          +LL SG  I+     
Sbjct: 333  LRTSGAD----TAKCGIHSMFPLH---------LAALNAHSDCCRKLLSSGFEIDTPDKF 379

Query: 622  GQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGAD 681
            G+T LH A    + +    L    AD +  + + G T L  A  N     ++ + T GA+
Sbjct: 380  GRTCLHAAAAGGNVECIKLLQSSGADFH-KKDKCGRTPLHYAAANCHFHCIETLVTTGAN 438

Query: 682  MSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAID-ENNEP 740
            ++  D+ G   L  A A+++ D   T++ +  D +             L RA + +  E 
Sbjct: 439  VNETDDWGRTALHYAAASDM-DRNKTILGNAHDNS-----------EELERARELKEKEA 486

Query: 741  TAC--FLIRSGCDVNSPRQPGANG---------------------EGEEEARDGQT--PL 775
            T C  FL+++  + +   + G N                       G EE+  G T  PL
Sbjct: 487  TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPL 546

Query: 776  HLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRD 835
            HLAA  G  + ++ LL+   +++ +D +GRT + +A    H   ++ L++ P   + V+D
Sbjct: 547  HLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKD 605

Query: 836  R-QGLTPFACAMTFKNNKSAEAILKRESG--AAEQVDNKGRNFLHVAVQNSDIESVLFLI 892
                 TP   ++   +      +L+      A +  D KG+  L +AV    I++V  L+
Sbjct: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665

Query: 893  SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
               ANV++   D    T LH  +  G E  V+ LL     +       +T LH AA +  
Sbjct: 666  EKEANVDT--VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723

Query: 953  PTICSVLLENGV---DFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQS 1009
             T  S LL+  +   D    D  G   LH A  +G  N I VLL +       F     +
Sbjct: 724  ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF--RKFIGNPFT 781

Query: 1010 PLH--ILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067
            PLH  I+  +G  N A+   L L  +    +   D  G T L  A    +    + ++R 
Sbjct: 782  PLHCAIINDHG--NCAS---LLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836

Query: 1068 GARLGVNNNQG 1078
             A +   +N G
Sbjct: 837  SAPVNAVDNSG 847



 Score =  147 bits (372), Expect = 4e-35
 Identities = 212/857 (24%), Positives = 334/857 (38%), Gaps = 157/857 (18%)

Query: 275  LVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYS 334
            L+    DV+ +D    + LH     GD      LI +GA VNA       TPLH      
Sbjct: 2    LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD-NMWLTPLHRA---- 56

Query: 335  SKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYV-FSQLLQCKQLD 393
                   V S   +  + L++  A+ N +D   +TPLHV+  A N+ V  ++++      
Sbjct: 57   -------VASRSEEAVQVLIKHSADVNARDKNWQTPLHVA--AANKAVKCAEVIIPLLSS 107

Query: 394  LELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAP 453
            + + D  G TAL     H  ++          V +VN            L+ +G++ +A 
Sbjct: 108  VNVSDRGGRTAL----HHAALNG--------HVEMVN-----------LLLAKGANINAF 144

Query: 454  DTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQ 513
            D       L  AA  G+      L  +GA V  ++K G TPLH A  +G  N+   LL  
Sbjct: 145  DKKDRRA-LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203

Query: 514  GANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHAT 573
            G    ++ +E                +V+  T LH+A       VV+ +++  AN     
Sbjct: 204  G----VEIDEI---------------NVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244

Query: 574  NNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQ 633
            NN      F+   +     L L            L+ +GA +N    DG++ LHM     
Sbjct: 245  NNGFTPLHFAAASTHGALCLEL------------LVNNGADVNIQSKDGKSPLHMTAVHG 292

Query: 634  DSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPL 693
                +  L+++  +I+    +DG T L +A R    L+++ + T GAD +        PL
Sbjct: 293  RFTRSQTLIQNGGEIDCV-DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPL 351

Query: 694  WLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVN 753
             LA  N   D    L+  G +       P    +T LH A    N      L  SG D +
Sbjct: 352  HLAALNAHSDCCRKLLSSGFEIDT----PDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407

Query: 754  SPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAIS 813
                        ++ + G+TPLH AA+      ++ L+  GANVN  D  GRT +H A +
Sbjct: 408  ------------KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA 455

Query: 814  S----------------------------QHGVIIQLLVSHPDIHLNVRDRQGLTPFACA 845
            S                            +  + ++ L+ + D + ++RD++G      A
Sbjct: 456  SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQN-DANPSIRDKEGYNSIHYA 514

Query: 846  MTFKNNKSAEAILKR--------ESGAAEQV--------------------------DNK 871
              + + +  E +L+R        +SGA +                            D K
Sbjct: 515  AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574

Query: 872  GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAG- 930
            GR  L +A      E V  LI+  A++  +  + +K TPLH +V  G  + +R LL    
Sbjct: 575  GRTALDLAAFKGHTECVEALINPGASIFVK-DNVTKRTPLHASVINGHTLCLRLLLEIAD 633

Query: 931  --AKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNN 988
                V+      QT L LA         S+LLE   +   VD  G  ALH  +M G    
Sbjct: 634  NPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEEC 693

Query: 989  IRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTV 1048
            +++LL E  V     + RG++PLH     G  +A  + +L    +        D  G T 
Sbjct: 694  VQMLL-EQEVSILCKDSRGRTPLHYAAARG--HATWLSELLQMALSEEDCCFKDNQGYTP 750

Query: 1049 LLLAYMKGNANLCRAIV 1065
            L  A   GN N    ++
Sbjct: 751  LHWACYNGNENCIEVLL 767



 Score =  141 bits (356), Expect = 3e-33
 Identities = 220/927 (23%), Positives = 351/927 (37%), Gaps = 166/927 (17%)

Query: 130 EDDVFLTELMKLANRFQLQLLRERCEKGVMSL------VNVRNCIRFYQTAEELNASTLM 183
           +D+++LT L +         +  R E+ V  L      VN R+  + +QT   + A+   
Sbjct: 45  KDNMWLTPLHRA--------VASRSEEAVQVLIKHSADVNARD--KNWQTPLHVAAANKA 94

Query: 184 NYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDS 243
             CAE+I      +   D    +A              LH A      ++V L L +   
Sbjct: 95  VKCAEVIIPLLSSVNVSDRGGRTA--------------LHHAALNGHVEMVNLLLAK--- 137

Query: 244 QLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLF 303
                +N  D     AL  A       +   L++H A+V   DK G++ LH     G + 
Sbjct: 138 --GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQIN 195

Query: 304 AATFLIKNGAFVNAATLGAQETPLHLVALYSSKK------------------------HS 339
               L+  G  ++   +    T LH +A Y+ +                         H 
Sbjct: 196 VVKHLLNLGVEIDEINVYGN-TALH-IACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253

Query: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
           A   +  A   E L+  GA+ N+Q   G++PLH++ + G  +  SQ L     +++  D 
Sbjct: 254 AAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR-FTRSQTLIQNGGEIDCVDK 312

Query: 400 EGSTALWLAVQH---------ITVSSDQSVNPFEDVPVVNGTSFDENSFAAR-LIQRGSH 449
           +G+T L +A ++          T  +D +      +  ++  + + +S   R L+  G  
Sbjct: 313 DGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372

Query: 450 TDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509
            D PD     CL   AAG GN      L ++GA  + ++K G TPLH A  +   +    
Sbjct: 373 IDTPDKFGRTCLHAAAAG-GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431

Query: 510 LLQQGANPNL--------------------------------QTEEALPLPKEAASLT-- 535
           L+  GAN N                                 + E A  L ++ A+L   
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLE 491

Query: 536 ---------SLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKD 586
                    S+ D     + +H A AY H   + ++LE+  +    +++           
Sbjct: 492 FLLQNDANPSIRDKEGYNS-IHYAAAYGHRQCLELLLERTNSGFEESDS----------- 539

Query: 587 SRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQA 646
              ++ L LA + G H     LL S   ++     G+T L +A  +  ++    L+   A
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599

Query: 647 DINVSRTQDGETALQLAIRNQLPLVVDA---ICTRGADMSVPDEKGNPPLWLALANNLED 703
            I V       T L  ++ N   L +     I      + V D KG  PL LA+A    D
Sbjct: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659

Query: 704 IASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG----CDVNSPRQP- 758
             S L+    +A        GC  T LHR I   +E     L+       C  +  R P 
Sbjct: 660 AVSLLLEK--EANVDTVDILGC--TALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL 715

Query: 759 ---GANGEG------------EEEA----RDGQTPLHLAASWGLEETVQCLLEFGANVNA 799
               A G              EE+       G TPLH A   G E  ++ LLE       
Sbjct: 716 HYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC-FRK 774

Query: 800 QDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL-NVRDRQGLTPFACAMTFKNNKSAEAIL 858
                 TP+H AI + HG    LL+   D  + + RD +G TP   A  F ++     +L
Sbjct: 775 FIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA-AFADHVECLQLL 833

Query: 859 KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG 918
            R S     VDN G+  L +A +N    +V  L++  A  +  V+D    TPLHLA   G
Sbjct: 834 LRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQADLTVKDKDLNTPLHLACSKG 892

Query: 919 SE---IIVRNLLLAGAKVNELTKHRQT 942
            E   +++ + +   + +NE     QT
Sbjct: 893 HEKCALLILDKIQDESLINEKNNALQT 919



 Score =  121 bits (304), Expect = 3e-27
 Identities = 123/450 (27%), Positives = 184/450 (40%), Gaps = 32/450 (7%)

Query: 641  LLEHQADINVSRTQDGE--TALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALA 698
            L+    D+N   T D E  T L +A       +++ +   GA ++  D     PL  A+A
Sbjct: 2    LIHKTEDVN---TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVA 58

Query: 699  NNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQP 758
            +  E+    L++H  D            QT LH A    N+   C       +V  P   
Sbjct: 59   SRSEEAVQVLIKHSADVNARDKN----WQTPLHVAAA--NKAVKC------AEVIIPLLS 106

Query: 759  GANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGV 818
              N       R G+T LH AA  G  E V  LL  GAN+NA D + R  +H A    H  
Sbjct: 107  SVNVSD----RGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLD 162

Query: 819  IIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHV 878
            ++ LL++H    +  +D++G TP   A +       + +L       ++++  G   LH+
Sbjct: 163  VVALLINH-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL-GVEIDEINVYGNTALHI 220

Query: 879  AVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA-GAKVNELT 937
            A  N     V  LI   ANVN    + +  TPLH A  +    +   LL+  GA VN  +
Sbjct: 221  ACYNGQDAVVNELIDYGANVNQ--PNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278

Query: 938  KHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECT 997
            K  ++ LH+ A     T    L++NG +   VD++GN  LH+A  +G    I  L T   
Sbjct: 279  KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTS-G 337

Query: 998  VDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGN 1057
             D     +    PLH+       +             G+ +D PD  G T L  A   GN
Sbjct: 338  ADTAKCGIHSMFPLHLAALNAHSDCCRKL-----LSSGFEIDTPDKFGRTCLHAAAAGGN 392

Query: 1058 ANLCRAIVRSGARLGVNNNQGVNIFNYQVA 1087
                + +  SGA     +  G    +Y  A
Sbjct: 393  VECIKLLQSSGADFHKKDKCGRTPLHYAAA 422


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  152 bits (384), Expect = 2e-36
 Identities = 170/651 (26%), Positives = 258/651 (39%), Gaps = 109/651 (16%)

Query: 443  LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502
            L++ G+H ++ D  T +C++++A     E +   L  NGA VN  +  G T L  A   G
Sbjct: 500  LVKAGAHVNSEDDRT-SCIVRQALE--REDSIRTLLDNGASVNQCDSNGRTLLANAAYSG 556

Query: 503  LANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562
              ++   L+ +GA+  L+ E+A                 H  TPL +A    H  VV+ +
Sbjct: 557  SLDVVNLLVSRGAD--LEIEDA-----------------HGHTPLTLAARQGHTKVVNCL 597

Query: 563  LEQKANALHATNN--------------------LQIIPDFSLKDSRDQTVLGLALWTGMH 602
            +   AN  H   +                    L         D+  +T L  A W G  
Sbjct: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657

Query: 603  TIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQL 662
             I   LL  GA +N   ++G+T L  A      +    LL+H A++N     DG TAL +
Sbjct: 658  DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN-HEDVDGRTALSV 716

Query: 663  AI-----RNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDAT- 716
            A            VV  +  RGA++   D+ G  PL +A      D+   L+  G D   
Sbjct: 717  AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776

Query: 717  -------------------------CWGP-------------------GPGGCLQTLLHR 732
                                      WG                    G    ++TLL R
Sbjct: 777  TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836

Query: 733  AIDENNEPTACFLIRSGCDVNSPR-------QPGANGEGEEEARDGQTPLHLAASWGLEE 785
             +DEN+   A +           R       + GA     E   DG+ P  LA+  G  +
Sbjct: 837  GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN--EIDNDGRIPFILASQEGHYD 894

Query: 786  TVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACA 845
             VQ LLE  +N++ +  +GR  + VA    H  I++LL SH    +N +D  G  P    
Sbjct: 895  CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GADVNCKDADG-RPTLYI 952

Query: 846  MTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDA 905
            +  +N  +            E  D +GR  LHV+     +E V  LI+ HA+VN+   D 
Sbjct: 953  LALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA--DN 1010

Query: 906  SKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVD 965
             K + L  A   G   +V+ L+  GA V+       TAL +AAQ+    +  VLLE+G D
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGAD 1070

Query: 966  FAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQ 1016
                D+ G  A+ +A  +G    I++L       A + N    SP+H + Q
Sbjct: 1071 PNHADQFGRTAMRVAAKNGHSQIIKLLE---KYGASSLNGCSPSPVHTMEQ 1118



 Score =  132 bits (332), Expect = 2e-30
 Identities = 132/497 (26%), Positives = 218/497 (43%), Gaps = 32/497 (6%)

Query: 586  DSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQ 645
            DS  +T+L  A ++G   +   L+  GA +    + G T L +A ++  +K    L+   
Sbjct: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601

Query: 646  ADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIA 705
            A+IN +  QDG TAL+ A       VV A+   G  +   D      L  A     EDI 
Sbjct: 602  ANINHT-DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660

Query: 706  STLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGE 765
              L++HG +        G   +T L  A    +      L+  G +VN            
Sbjct: 661  LNLLQHGAEVNK-ADNEG---RTALIAAAYMGHREIVEHLLDHGAEVN------------ 704

Query: 766  EEARDGQTPLHLAA-----SWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVII 820
             E  DG+T L +AA     S G    V  L++ GA V+  D +G TP+ VA    H  ++
Sbjct: 705  HEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVV 764

Query: 821  QLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAV 880
             LL+      ++  D  G TP   A +  +      +L     A + +D++GR  L +A 
Sbjct: 765  DLLLEG-GADVDHTDNNGRTPLLAAASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIAS 822

Query: 881  QNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHR 940
               ++E V  L+    + N R  D +  TPLH+A   G  +I   L+  GA+ NE+    
Sbjct: 823  AQGNVEVVRTLLDRGLDENHR--DDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880

Query: 941  QTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDA 1000
            +    LA+Q+       +LLEN  +      +G NAL +A + G  + + +L +    D 
Sbjct: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GADV 939

Query: 1001 EAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANL 1060
               +  G+  L+IL     EN   + + FLE   G  ++  DA+G T L ++  +G+  +
Sbjct: 940  NCKDADGRPTLYIL---ALENQLTMAEYFLE--NGANVEASDAEGRTALHVSCWQGHMEM 994

Query: 1061 CRAIVRSGARLGVNNNQ 1077
             + ++   A +   +N+
Sbjct: 995  VQVLIAYHADVNAADNE 1011



 Score =  128 bits (322), Expect = 3e-29
 Identities = 184/764 (24%), Positives = 298/764 (39%), Gaps = 111/764 (14%)

Query: 161  LVNVRNCIRFYQ-TAEELNASTLMNYCAEIIASHWDDLRKEDFSSM---------SAQLL 210
            L++V++C + Y   A E +    M+Y  +  A +   L  ++F+           +A+L 
Sbjct: 415  LLDVKHCTQKYLCNAAEGHRMLAMSYTCQ--AKNLTPLEAQEFALHLINSNLQLETAELA 472

Query: 211  YKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES 270
              MI + T      +  + +E  V   L++  + +    N  D      +  AL R  E 
Sbjct: 473  LWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHV----NSEDDRTSCIVRQALER--ED 526

Query: 271  IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
               TL+ + A V+  D +G +LL      G L     L+  GA +         TPL L 
Sbjct: 527  SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTLA 585

Query: 331  ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
            A     K           +   L+  GAN N  D  G T L  +   G+  V S LL   
Sbjct: 586  ARQGHTK-----------VVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634

Query: 391  QLDLELKDHEGSTAL----WLAVQHITVSSDQ---SVNPFED---VPVVNGTSFDENSFA 440
             + ++  D +  TAL    W   + I ++  Q    VN  ++     ++           
Sbjct: 635  -VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693

Query: 441  ARLIQRGSHTDAPD----TATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLH 496
              L+  G+  +  D    TA     L   A  G+ +    L   GA V+H +K G TPL 
Sbjct: 694  EHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL 753

Query: 497  TACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHL------------- 543
             A   G  ++   LL+ GA+ +  T+     P  AA+    A  V+              
Sbjct: 754  VAAYEGHVDVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 812

Query: 544  --QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601
              +T L +A A  + +VV  +L++  +  H             +D    T L +A + G 
Sbjct: 813  EGRTVLSIASAQGNVEVVRTLLDRGLDENH-------------RDDAGWTPLHMAAFEGH 859

Query: 602  HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661
              I   L+  GA  N+  +DG+    +A Q         LLE++++I+  R  DG  AL+
Sbjct: 860  RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID-QRGYDGRNALR 918

Query: 662  LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721
            +A       +V+ + + GAD++  D  G P L++    N   +A   + +G +       
Sbjct: 919  VAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEA-SDA 977

Query: 722  PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQP------GANGEG----------- 764
             G   +T LH +  + +      LI    DVN+           A  +G           
Sbjct: 978  EG---RTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034

Query: 765  ----EEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVII 820
                +     G T L +AA  G  + VQ LLE GA+ N  D  GRT + VA  + H  II
Sbjct: 1035 GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQII 1094

Query: 821  QLLVSHPDIHLN-----------VRDRQGLTPFACAMTFKNNKS 853
            +LL  +    LN            +  Q L+    ++T K+N S
Sbjct: 1095 KLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138



 Score =  126 bits (317), Expect = 1e-28
 Identities = 155/589 (26%), Positives = 233/589 (39%), Gaps = 72/589 (12%)

Query: 353  LLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA---- 408
            LL  GA+ N  DS GRT L  +  +G+  V + LL  +  DLE++D  G T L LA    
Sbjct: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVN-LLVSRGADLEIEDAHGHTPLTLAARQG 589

Query: 409  ---VQHITVSSDQSVNPFED---VPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLL 462
               V +  +    ++N  +      + +          + L+  G   D  D A     L
Sbjct: 590  HTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD-ADSRTAL 648

Query: 463  QRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTE 522
            + AA  G+E   L L  +GA VN  +  G T L  A   G   +   LL  GA  N +  
Sbjct: 649  RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV 708

Query: 523  EA----------LPLPKEAASLTSL-----ADSVHLQ----TPLHMAIAYNHPDVVSVIL 563
            +           +P  K  AS+ SL     A+  H      TPL +A    H DVV ++L
Sbjct: 709  DGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768

Query: 564  EQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQ 623
            E  A+  H  NN              +T L  A   G  ++   LL  GAA++   S+G+
Sbjct: 769  EGGADVDHTDNN-------------GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815

Query: 624  TLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMS 683
            T+L +A  + + +    LL+   D N  R   G T L +A      L+ +A+  +GA  +
Sbjct: 816  TVLSIASAQGNVEVVRTLLDRGLDEN-HRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874

Query: 684  VPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTAC 743
              D  G  P  LA      D    L+ +  +    G      L+     A  E +     
Sbjct: 875  EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRV----AALEGHRDIVE 930

Query: 744  FLIRSGCDVNSPRQPGA--------------------NGEGEEEA-RDGQTPLHLAASWG 782
             L   G DVN     G                     NG   E +  +G+T LH++   G
Sbjct: 931  LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990

Query: 783  LEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPF 842
              E VQ L+ + A+VNA D E R+ +  A    H  ++QLL+ H  + ++    QG T  
Sbjct: 991  HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV-VDHTCNQGATAL 1049

Query: 843  ACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFL 891
             C    + +     +L          D  GR  + VA +N   + +  L
Sbjct: 1050 -CIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097



 Score =  125 bits (313), Expect = 3e-28
 Identities = 124/477 (25%), Positives = 202/477 (42%), Gaps = 34/477 (7%)

Query: 608  LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
            LL +GA++N   S+G+TLL  A           L+   AD+ +     G T L LA R  
Sbjct: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAH-GHTPLTLAARQG 589

Query: 668  LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQ 727
               VV+ +   GA+++  D+ G   L  A      ++ S L+  G    C         +
Sbjct: 590  HTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS----R 645

Query: 728  TLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETV 787
            T L  A    +E     L++ G +VN            +   +G+T L  AA  G  E V
Sbjct: 646  TALRAAAWGGHEDIVLNLLQHGAEVN------------KADNEGRTALIAAAYMGHREIV 693

Query: 788  QCLLEFGANVNAQDAEGRTPIHVAI-----SSQHGVIIQLLVSHPDIHLNVRDRQGLTPF 842
            + LL+ GA VN +D +GRT + VA      S  H  ++ LL+      ++  D+ G+TP 
Sbjct: 694  EHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR-GAEVDHCDKDGMTPL 752

Query: 843  ACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRV 902
              A  ++ +     +L       +  DN GR  L  A        V  L+   A V+S  
Sbjct: 753  LVA-AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI- 810

Query: 903  QDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLEN 962
             D+   T L +A   G+  +VR LL  G   N       T LH+AA +    IC  L+E 
Sbjct: 811  -DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869

Query: 963  GVDFAAVDENGNNALHLAVMHGRLNNIRVLL-TECTVDAEAFNLRGQSPLHILGQYGKEN 1021
            G     +D +G     LA   G  + +++LL  +  +D   ++  G++ L +    G  +
Sbjct: 870  GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYD--GRNALRVAALEGHRD 927

Query: 1022 AAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
               +  LF     G  ++  DADG   L +  ++    +    + +GA +  ++ +G
Sbjct: 928  IVEL--LFSH---GADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEG 979



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 116/459 (25%), Positives = 187/459 (40%), Gaps = 42/459 (9%)

Query: 625  LLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSV 684
            L++  +Q + ++ AL+++      N +  +D  + L    +  L L+V A    GA ++ 
Sbjct: 459  LINSNLQLETAELALWMIW-----NGTPVRDSLSTLIPKEQEVLQLLVKA----GAHVNS 509

Query: 685  PDEKGNPPLWLALANNLEDIASTLVRHGCDAT-CWGPGPGGCLQTLLHRAIDENNEPTAC 743
             D++ +  +  AL    ED   TL+ +G     C   G     +TLL  A    +     
Sbjct: 510  EDDRTSCIVRQALER--EDSIRTLLDNGASVNQCDSNG-----RTLLANAAYSGSLDVVN 562

Query: 744  FLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAE 803
             L+  G D+            E E   G TPL LAA  G  + V CL+  GAN+N  D +
Sbjct: 563  LLVSRGADL------------EIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610

Query: 804  GRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESG 863
            G T +  A    H  ++  L+ +  + ++  D    T    A  +  ++     L +   
Sbjct: 611  GWTALRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAA-AWGGHEDIVLNLLQHGA 668

Query: 864  AAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQD---ASKLTPLHLAVQAGSE 920
               + DN+GR  L  A      E V  L+   A VN    D   A  +  L +    G  
Sbjct: 669  EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728

Query: 921  IIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLA 980
             +V  L+  GA+V+   K   T L +AA +    +  +LLE G D    D NG   L  A
Sbjct: 729  SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788

Query: 981  VMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGK-ENAAAIFDLFLECMPGYPLD 1039
               G  + +  LL       ++ +  G++ L I    G  E    + D       G   +
Sbjct: 789  ASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDR------GLDEN 841

Query: 1040 KPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
              D  G T L +A  +G+  +C A++  GAR    +N G
Sbjct: 842  HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 93/343 (27%), Positives = 149/343 (43%), Gaps = 27/343 (7%)

Query: 745  LIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEG 804
            L+++G  VNS               D +T   +  +   E++++ LL+ GA+VN  D+ G
Sbjct: 500  LVKAGAHVNS--------------EDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNG 545

Query: 805  RTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGA 864
            RT +  A  S    ++ LLVS     L + D  G TP   A    + K    ++   +  
Sbjct: 546  RTLLANAAYSGSLDVVNLLVSR-GADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604

Query: 865  AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVR 924
                D  G   L  A      E V  L+  +A V     DA   T L  A   G E IV 
Sbjct: 605  -NHTDQDGWTALRSAAWGGHTEVVSALL--YAGVKVDCADADSRTALRAAAWGGHEDIVL 661

Query: 925  NLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHG 984
            NLL  GA+VN+     +TAL  AA      I   LL++G +    D +G  AL +A +  
Sbjct: 662  NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721

Query: 985  RLN----NIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDK 1040
              +    ++  LL +   + +  +  G +PL +    G  +   + DL LE   G  +D 
Sbjct: 722  PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD---VVDLLLE--GGADVDH 776

Query: 1041 PDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFN 1083
             D +G T LL A   G+A++   ++  GA +   +++G  + +
Sbjct: 777  TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  140 bits (353), Expect = 7e-33
 Identities = 209/882 (23%), Positives = 348/882 (39%), Gaps = 123/882 (13%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
            +N     G+ AL  A +     +   L+   A ++  +++G + L +    G +  A  L
Sbjct: 327  VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386

Query: 309  IKNGAFVN---------AATLGAQETPLHLVALY----SSKKHSADVMSEM--------- 346
            ++NGA +N         A TL   +  L +V       + ++H  D M            
Sbjct: 387  LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446

Query: 347  AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALW 406
             ++A  LL +GA  NM      +PL ++   G+  + + L++ +   LE  + EG T L 
Sbjct: 447  VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE-RGASLEEVNDEGYTPLM 505

Query: 407  LAVQH-----ITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATG--- 458
             A +      + +   Q  N       +N  + +    A  L   G   +  D       
Sbjct: 506  EAAREGHEEMVALLLGQGAN-------INAQTEETQETALTLACCGGFLEVADFLIKAGA 558

Query: 459  ------NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ 512
                  +  L  AA  G+     +L   GA+V+     G+T L  AC +G  ++   LLQ
Sbjct: 559  DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618

Query: 513  QGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHA 572
             GA+   ++E                     +TPL  A    H   V  ++ + AN    
Sbjct: 619  AGADLEHESEGG-------------------RTPLMKAARAGHVCTVQFLISKGANVNRT 659

Query: 573  TNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQR 632
            T N             D TVL LA   G   +   LL  GA     + DG T+L  A + 
Sbjct: 660  TAN------------NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707

Query: 633  QDSKSALFLLEHQADI------NVSRTQDGETALQLAIR---NQLPLVVDAICTRGADMS 683
              +    +LL++  ++      +V++       L  A R     LP+VV           
Sbjct: 708  GHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVP---------- 757

Query: 684  VPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTAC 743
             P E   PP          ++A+TL       +             +  +I +   PT  
Sbjct: 758  -PQEPDKPPA---------NVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPS 807

Query: 744  FLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAE 803
             +I     +  P  P  + + + E+    T L LA + G EE VQ LLE GA++  +D +
Sbjct: 808  PIISPSAML--PIYPAIDIDAQTESNH-DTALTLACAGGHEELVQTLLERGASIEHRDKK 864

Query: 804  GRTPIHVAISSQH-GVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRES 862
            G TP+ +A ++ H GV+  LL +  DI     +R   TP + A +    +  E +L R  
Sbjct: 865  GFTPLILAATAGHVGVVEILLDNGADIEAQ-SERTKDTPLSLACSGGRQEVVELLLAR-- 921

Query: 863  GAAEQVDN-KGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEI 921
            GA ++  N      L +A     +  +  L++  A +NSR      ++PL LA   G   
Sbjct: 922  GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTA 981

Query: 922  IVRNLLLAGAKVN-ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLA 980
             V+ LL  G+ +N ++  +R TAL LA  Q    + S+LL+   +     + G   L  A
Sbjct: 982  AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1041

Query: 981  VMHGRLNNIRVLLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECM--PGYP 1037
               G     RVLL +   V+A        + L I    G          F E +   G  
Sbjct: 1042 ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYK-------FCELLIGRGAH 1094

Query: 1038 LDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
            +D  +  G+T L LA   G+ ++ + +V++GA +   +N+ +
Sbjct: 1095 IDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKI 1136



 Score =  135 bits (340), Expect = 2e-31
 Identities = 224/883 (25%), Positives = 342/883 (38%), Gaps = 93/883 (10%)

Query: 249  LNEADHNGDLALDLALSRRLESIATTLVSHKADV-DMVDKSGWSLLHKGIQRGDLFAATF 307
            +NE    G+  L LA S     +A  L++  A+V D   K   + L      G +     
Sbjct: 260  VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKL 319

Query: 308  LIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
            L+ + A VNA     Q +  +    Y+      DV+       + LL++GA+    +  G
Sbjct: 320  LLAHKADVNA-----QSSTGNTALTYACAGGYVDVV-------KVLLESGASIEDHNENG 367

Query: 368  RTPLHVSIMAGNEYVFSQLLQ-----------CKQLDLELKDHEGSTALWLAVQHITVSS 416
             TPL  +  AG+  V   LL+            K+  L L  ++G   +   +  +   +
Sbjct: 368  HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL--LEAGA 425

Query: 417  DQSVNPFEDVPVVNGTSFDENSFAARLI-QRGSHTDAPDTATGNCLLQRAAGAGNEAAAL 475
            DQ     E    +     D +   ARL+   G+  + P  +  + L   A G   E AAL
Sbjct: 426  DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485

Query: 476  FLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE----ALPLP--- 528
             L   GA +   N  G TPL  A R G   + A LL QGAN N QTEE    AL L    
Sbjct: 486  -LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544

Query: 529  ---KEAASLTSLADSVHL--QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 583
               + A  L      + L   TPL  A    H ++V  +L   AN +HAT          
Sbjct: 545  GFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGAN-VHATT--------- 594

Query: 584  LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 643
               +   T L  A   G   +A  LL +GA +      G+T L  A +     +  FL+ 
Sbjct: 595  ---ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651

Query: 644  HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLED 703
              A++N +   +  T L LA       VV+ +   GAD +   + G+  L  A       
Sbjct: 652  KGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTS 711

Query: 704  IASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEP-TACFLIRSGCDVNSPRQPGANG 762
            +   L+ +  +       P   +  L   + D N  P      +        P +P AN 
Sbjct: 712  VVCYLLDYPNNLL---SAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANV 768

Query: 763  EGEEEARD----------GQTPLH-LAASWGLEET----------VQCLLEFGANVNAQ- 800
                  R+            TP H +AAS    +T              +    +++AQ 
Sbjct: 769  ATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQT 828

Query: 801  DAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKR 860
            ++   T + +A +  H  ++Q L+      +  RD++G TP   A T  +    E +L  
Sbjct: 829  ESNHDTALTLACAGGHEELVQTLLER-GASIEHRDKKGFTPLILAATAGHVGVVEILLDN 887

Query: 861  ESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSE 920
             +    Q +      L +A      E V  L++  AN   R  + S  TPL LA   G  
Sbjct: 888  GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR--NVSDYTPLSLAASGGYV 945

Query: 921  IIVRNLLLAGAKVNELT--KHRQTALHLAAQQDLPTICSVLLENGVDF-AAVDENGNNAL 977
             I++ LL AGA++N  T  K   + L LAA         +LL+ G D  A ++ N N AL
Sbjct: 946  NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTAL 1005

Query: 978  HLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYP 1037
             LA   GR   + +LL +   + E     G +PL      G      +         G  
Sbjct: 1006 TLACFQGRTEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVL-----LDKGAD 1059

Query: 1038 LDKPDADGS--TVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
            ++ P    S  T L +A  KG+   C  ++  GA + V N +G
Sbjct: 1060 VNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKG 1102



 Score =  116 bits (290), Expect = 1e-25
 Identities = 153/615 (24%), Positives = 226/615 (36%), Gaps = 102/615 (16%)

Query: 256  GDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFV 315
            GD AL  A       +A  L+   AD++   + G + L K  + G +    FLI  GA V
Sbjct: 597  GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANV 656

Query: 316  NAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSI 375
            N  T     T L L     +  H A        + E LL  GA+P  +   G T L  + 
Sbjct: 657  NRTTANNDHTVLSLAC---AGGHLA--------VVELLLAHGADPTHRLKDGSTMLIEAA 705

Query: 376  MAGNEYVFSQLLQCKQ----------LDLELKDHEGSTALWLAVQHITV------SSDQS 419
              G+  V   LL                L    H+ + A  + VQ + +           
Sbjct: 706  KGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPP 765

Query: 420  VNPFEDVPVVNG---------TSFDENSFAARLIQRGSHT-------------------D 451
             N    +P+ N          ++   +S AA + Q  + T                   D
Sbjct: 766  ANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 825

Query: 452  APDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELL 511
            A   +  +  L  A   G+E     L   GA + HR+K G TPL  A   G   +   LL
Sbjct: 826  AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885

Query: 512  QQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALH 571
              GA+   Q+E                      TPL +A +    +VV ++L + AN  H
Sbjct: 886  DNGADIEAQSERTK------------------DTPLSLACSGGRQEVVELLLARGANKEH 927

Query: 572  ATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSD--GQTLLHMA 629
                         ++  D T L LA   G   I   LL +GA IN       G + L +A
Sbjct: 928  -------------RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 974

Query: 630  IQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKG 689
                 + +   LL+  +DIN     +  TAL LA       VV  +  R A++    + G
Sbjct: 975  AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTG 1034

Query: 690  NPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSG 749
              PL  A +    ++   L+  G D     P       T L  A D+ +      LI  G
Sbjct: 1035 LTPLMEAASGGYAEVGRVLLDKGADVNA--PPVPSSRDTALTIAADKGHYKFCELLIGRG 1092

Query: 750  CDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIH 809
              +            +   + G TPL LAA+ G  + VQ L++ GA+V+A D    TP+ 
Sbjct: 1093 AHI------------DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1140

Query: 810  VAISSQHGVIIQLLV 824
             A    H  +++ LV
Sbjct: 1141 AAFRKGHVKVVRYLV 1155



 Score =  114 bits (284), Expect = 7e-25
 Identities = 192/799 (24%), Positives = 296/799 (37%), Gaps = 106/799 (13%)

Query: 265  SRRLESIATTLVSHKADVDMVD---KSGWSLLHK----------GIQRGDLFAATFLIKN 311
            S   +  A TL  +K  ++MV    ++G    HK              G +  A  L+ +
Sbjct: 397  SNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 456

Query: 312  GAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPL 371
            GA VN     + E+PL L A                ++A  L++ GA+    + +G TPL
Sbjct: 457  GAQVNMPA-DSFESPLTLAACGGH-----------VELAALLIERGASLEEVNDEGYTPL 504

Query: 372  HVSIMAGNEYVFSQLL-QCKQLDLELKDHEGSTALWLA-------VQHITVSSDQSVNPF 423
              +   G+E + + LL Q   ++ + ++ +  TAL LA       V    + +   +   
Sbjct: 505  MEAAREGHEEMVALLLGQGANINAQTEETQ-ETALTLACCGGFLEVADFLIKAGADIELG 563

Query: 424  EDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAH 483
               P++             L+  G++  A  TATG+  L  A   G+   A  L   GA 
Sbjct: 564  CSTPLMEAAQEGHLELVKYLLAAGANVHAT-TATGDTALTYACENGHTDVADVLLQAGAD 622

Query: 484  VNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE----ALPLPKEAASLTSL-- 537
            + H ++ G TPL  A R G       L+ +GAN N  T       L L      L  +  
Sbjct: 623  LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL 682

Query: 538  -----ADSVHL----QTPLHMAIAYNHPDVVSVILEQKANAL--------------HATN 574
                 AD  H      T L  A    H  VV  +L+   N L              H  N
Sbjct: 683  LLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLN 742

Query: 575  N-----LQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT--------MSD 621
                  +Q +P        D+    +A    +   A    G  +A+++T        +S 
Sbjct: 743  RAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS--GRASAMSNTPTHSIAASISQ 800

Query: 622  GQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGAD 681
             QT     I    S SA+  +    DI+     + +TAL LA       +V  +  RGA 
Sbjct: 801  PQTPTPSPII---SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGAS 857

Query: 682  MSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPT 741
            +   D+KG  PL LA       +   L+ +G D                  A  E  + T
Sbjct: 858  IEHRDKKGFTPLILAATAGHVGVVEILLDNGADI----------------EAQSERTKDT 901

Query: 742  ACFLIRSGCDVNSPRQPGANGEGEEEAR-DGQTPLHLAASWGLEETVQCLLEFGANVNAQ 800
               L  SG          A G  +E       TPL LAAS G    ++ LL  GA +N++
Sbjct: 902  PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 961

Query: 801  DAE--GRTPIHVAISSQHGVIIQLLVSH-PDIHLNVR-DRQGLTPFACAMTFKNNKSAEA 856
                 G +P+ +A  + H   ++LL+    DI+  +  +R      AC   F+      +
Sbjct: 962  TGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC---FQGRTEVVS 1018

Query: 857  ILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQ 916
            +L       E     G   L  A      E    L+   A+VN+    +S+ T L +A  
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078

Query: 917  AGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNA 976
             G       L+  GA ++   K   T L LAA      +  +L++ G D  A D      
Sbjct: 1079 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1138

Query: 977  LHLAVMHGRLNNIRVLLTE 995
            L  A   G +  +R L+ E
Sbjct: 1139 LMAAFRKGHVKVVRYLVKE 1157



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 147/555 (26%), Positives = 206/555 (37%), Gaps = 89/555 (16%)

Query: 455 TATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG 514
           T++ +C L  AA A     A   A  G   N         L  AC  G  N   +LL +G
Sbjct: 205 TSSVSCALDEAAAALTRMRAESTANAGQSDNRS-------LAEACSEGDVNAVRKLLIEG 257

Query: 515 ANPNLQTEEALPLPKEAAS-----LTSLADSVHLQ----------TPLHMAIAYNHPDVV 559
            + N  TEE   L   A S     L  +  ++H            TPL  A    H  +V
Sbjct: 258 RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIV 317

Query: 560 SVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTM 619
            ++L  KA             D + + S   T L  A   G   +   LL SGA+I D  
Sbjct: 318 KLLLAHKA-------------DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 620 SDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRG 679
            +G T L  A      + A  LLE+ A IN    +  E+AL LA       +V  +   G
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424

Query: 680 ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNE 739
           AD     ++ +  L  A  +   ++A  L+  G         P    ++ L  A    + 
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLAACGGHV 480

Query: 740 PTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNA 799
             A  LI  G  +            EE   +G TPL  AA  G EE V  LL  GAN+NA
Sbjct: 481 ELAALLIERGASL------------EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528

Query: 800 QDAEGR-------------------------------TPIHVAISSQHGVIIQ-LLVSHP 827
           Q  E +                               TP+  A    H  +++ LL +  
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGA 588

Query: 828 DIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIE 886
           ++H           +AC    +N  +  A +  ++GA  E     GR  L  A +   + 
Sbjct: 589 NVHATTATGDTALTYAC----ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644

Query: 887 SVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHL 946
           +V FLIS  ANVN R    +  T L LA   G   +V  LL  GA      K   T L  
Sbjct: 645 TVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703

Query: 947 AAQQDLPTICSVLLE 961
           AA+    ++   LL+
Sbjct: 704 AAKGGHTSVVCYLLD 718



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 74/332 (22%), Positives = 126/332 (37%), Gaps = 70/332 (21%)

Query: 251  EADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIK 310
            + + N D AL LA +   E +  TL+   A ++  DK G++ L      G +     L+ 
Sbjct: 827  QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886

Query: 311  NGAFVNAATLGAQETPLHL-------------VALYSSKKH---------SADVMSEMAQ 348
            NGA + A +   ++TPL L             +A  ++K+H         S         
Sbjct: 887  NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946

Query: 349  IAEALLQAGANPNMQDSK--GRTPLHVSIMAGNEYVFSQLLQC-KQLDLELKDHEGSTAL 405
            I + LL AGA  N +     G +PL ++ M G+      LL     ++ +++ +  +TAL
Sbjct: 947  IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-NTAL 1005

Query: 406  WLA-----VQHITVSSDQSVNPFEDV-----PVVNGTSFDENSFAARLIQRGSHTDAPDT 455
             LA      + +++  D+  N          P++   S         L+ +G+  +AP  
Sbjct: 1006 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065

Query: 456  ATG-NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLH------------------ 496
             +  +  L  AA  G+      L   GAH++ RNK G TPL                   
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125

Query: 497  ---------------TACRHGLANLTAELLQQ 513
                            A R G   +   L+++
Sbjct: 1126 ADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 40/174 (22%), Positives = 76/174 (43%), Gaps = 26/174 (14%)

Query: 238  LIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGI 297
            L++M S +  ++   + N + AL LA  +    + + L+  KA+V+   K+G + L +  
Sbjct: 986  LLDMGSDINAQI---ETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA 1042

Query: 298  QRGDLFAATFLIKNGAFVNAATL-GAQETPLHLVA---------LYSSKKHSADVMSEMA 347
              G       L+  GA VNA  +  +++T L + A         L   +    DV ++  
Sbjct: 1043 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKG 1102

Query: 348  Q-------------IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
                          + + L+QAGA+ +  D++  TPL  +   G+  V   L++
Sbjct: 1103 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  136 bits (342), Expect = 1e-31
 Identities = 194/795 (24%), Positives = 300/795 (37%), Gaps = 117/795 (14%)

Query: 246 PGKLNEADHNG--DLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLF 303
           P K+N  D  G     L  A     + +   L+ + A+V   D  G   LH     G   
Sbjct: 46  PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAE 105

Query: 304 AATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQ 363
               L+++GA  NA       TPLH  A+    K   DV          LLQ GA P ++
Sbjct: 106 VVNLLLRHGADPNARD-NWNYTPLHEAAI----KGKIDVCI-------VLLQHGAEPTIR 153

Query: 364 DSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPF 423
           ++ GRT L ++  +    +  +  + + L+     +E      L   ++   +       
Sbjct: 154 NTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR--- 210

Query: 424 EDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCL-LQRAAGAGNEAAALFLATNGA 482
           +  P+     ++       L+Q G+   A D   G+ + L  A   G+      L  +GA
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK--GDLVPLHNACSYGHYEVTELLVKHGA 268

Query: 483 HVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNL---------------QTEEALPL 527
            VN  + W  TPLH A       + + LL  GA+P L               Q +E L  
Sbjct: 269 CVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAY 328

Query: 528 PKEAASLTSLADSV-------HL-------------QTPLHMAIAYNHP---DVVSVILE 564
             +  SL   A          HL             +T LH A A  +P    +  ++L 
Sbjct: 329 EFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLR 388

Query: 565 QKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQT 624
           + AN    T                 T L +A     + +   ++   A +N   + GQT
Sbjct: 389 KGANINEKTKEFL-------------TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQT 435

Query: 625 LLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSV 684
            LH A      ++   LL +  D N+   Q G TALQ+   N   L+ + I    +    
Sbjct: 436 SLHRAAYCGHLQTCRLLLSYGCDPNIISLQ-GFTALQMGNENVQQLLQEGISLGNS---- 490

Query: 685 PDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACF 744
             E     L  A A ++E +         +         G   T LH A   N      +
Sbjct: 491 --EADRQLLEAAKAGDVETVKKLCTVQSVNCR----DIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 745 LIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEG 804
           L++ G DV++            + + G  PLH A S+G  E  + L++ GA VN  D   
Sbjct: 545 LLQHGADVHA------------KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK 592

Query: 805 RTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPF----------------ACAMTF 848
            TP+H A +     I +LL+ H       ++R G TP                   A+  
Sbjct: 593 FTPLHEAAAKGKYEICKLLLQH-GADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651

Query: 849 KNNKSAEAILKRESGA--AEQVDNKGRNF--LHVAVQNSDIESVLFLISVHANVNSRVQD 904
              K   A +K+ S        D +GR+   LH+A   +++E   +L+   A+VN+  QD
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA--QD 709

Query: 905 ASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGV 964
              L PLH A   G   +   L+   A VN   K   T LH AAQ+    +C++LL +G 
Sbjct: 710 KGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 769

Query: 965 DFAAVDENGNNALHL 979
           D    ++ G   L L
Sbjct: 770 DPTLKNQEGQTPLDL 784



 Score =  132 bits (331), Expect = 3e-30
 Identities = 206/842 (24%), Positives = 328/842 (38%), Gaps = 143/842 (16%)

Query: 293  LHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSK-------KHSADVMSE 345
            L +  + GD+     L+      +  T G + TPLH  A +  K       ++ A+V + 
Sbjct: 28   LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87

Query: 346  ---------------MAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
                            A++   LL+ GA+PN +D+   TPLH + + G   V   LLQ  
Sbjct: 88   DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ-H 146

Query: 391  QLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHT 450
              +  +++ +G TAL LA    +  +  +    +D  + +  S +E    A L     + 
Sbjct: 147  GAEPTIRNTDGRTALDLA--DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNC 204

Query: 451  DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAEL 510
             A D    +  L  AAG         L  +GA V+ ++K    PLH AC +G   +T  L
Sbjct: 205  HASD-GRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELL 263

Query: 511  LQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA- 569
            ++ GA  N                   A  +   TPLH A + N  +V S++L   A+  
Sbjct: 264  VKHGACVN-------------------AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304

Query: 570  ---LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLL 626
                H  + + + P   LK+                 +A +  G                
Sbjct: 305  LLNCHNKSAIDLAPTPQLKE----------------RLAYEFKG---------------- 332

Query: 627  HMAIQRQDSKSALFLLEHQA--DINVSRTQDGETALQLAIRNQLP---LVVDAICTRGAD 681
            H  +Q         + +H +   +N    Q  ETAL  A  +  P    + + +  +GA+
Sbjct: 333  HSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN 392

Query: 682  MSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPT 741
            ++   ++   PL +A      D+   +V+H               QT LHRA    +  T
Sbjct: 393  INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL----DNLGQTSLHRAAYCGHLQT 448

Query: 742  ACFLIRSGCDVNSPRQPG--ANGEGEEEAR------------DGQTPLHLAASWGLEETV 787
               L+  GCD N     G  A   G E  +            +    L  AA  G  ETV
Sbjct: 449  CRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETV 508

Query: 788  QCLLEFGANVNAQDAEGR--TPIHVAISSQHGVIIQLLVSH-PDIHLNVRDRQGLTPFAC 844
            + L     +VN +D EGR  TP+H A       +++ L+ H  D+H   +D+ GL P   
Sbjct: 509  KKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH--AKDKGGLVPLHN 565

Query: 845  AMTFKNNKSAEAILKRESGAAEQVDNKGR-NFLHVAVQNSDIESVLFLISVHANVNSRVQ 903
            A ++ + + AE ++K   GA   V +  +   LH A      E    L+   A+   + +
Sbjct: 566  ACSYGHYEVAELLVKH--GAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623

Query: 904  DASKLTPLHLAVQAGSEI--IVRN--LLLAGAKVNELTK-----------------HRQT 942
            D +  TPL L     ++I  ++R    LL  AK   L +                    T
Sbjct: 624  DGN--TPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHST 681

Query: 943  ALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEA 1002
             LHLAA  +   +   LL++G D  A D+ G   LH A  +G + ++  LL +      A
Sbjct: 682  PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHV-DVAALLIKYNACVNA 740

Query: 1003 FNLRGQSPLHILGQYGKENAAAIF-----DLFLECMPGY-PLDKPDADGSTVLLLAYMKG 1056
             +    +PLH   Q G+    A+      D  L+   G  PLD   AD  + LL A M  
Sbjct: 741  TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPP 800

Query: 1057 NA 1058
            +A
Sbjct: 801  SA 802



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 111/464 (23%), Positives = 178/464 (38%), Gaps = 46/464 (9%)

Query: 269 ESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA-TLGAQETPL 327
           + I   L+   A+++   K   + LH   ++        ++K+ A VNA   LG  +T L
Sbjct: 380 KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG--QTSL 437

Query: 328 HLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLL 387
           H  A                Q    LL  G +PN+   +G T L +    GNE V  QLL
Sbjct: 438 HRAAYCGH-----------LQTCRLLLSYGCDPNIISLQGFTALQM----GNENV-QQLL 481

Query: 388 Q------CKQLDLELKDHEGSTALWLAVQHITVSSD--QSVNPFEDVPVVNGTSFDENSF 439
           Q        + D +L +   +  +    +  TV S   + +   +  P+     ++  S 
Sbjct: 482 QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSV 541

Query: 440 AARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTAC 499
              L+Q G+   A D   G   L  A   G+   A  L  +GA VN  + W  TPLH A 
Sbjct: 542 VEYLLQHGADVHAKDKG-GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600

Query: 500 RHGLANLTAELLQQGANPNLQTEEA-LPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 558
             G   +   LLQ GA+P  +  +   PL       T + D +     L  A        
Sbjct: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAA------- 653

Query: 559 VSVILEQKANALHATNNLQIIPDFSLKDS--RDQTVLGLALWTGMHTIAAQLLGSGAAIN 616
                  K   L     L    + + +D+  R  T L LA       +A  LL  GA +N
Sbjct: 654 -------KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 617 DTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAIC 676
                G   LH A        A  L+++ A +N +  +   T L  A +     +   + 
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT-DKWAFTPLHEAAQKGRTQLCALLL 765

Query: 677 TRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP 720
             GAD ++ +++G  PL L  A+++  + +  +      +C+ P
Sbjct: 766 AHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKP 809



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 84/322 (26%), Positives = 122/322 (37%), Gaps = 78/322 (24%)

Query: 214 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 273
           I+ +   PLH A    R  VV  YL++  + +  K    D  G + L  A S     +A 
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVE-YLLQHGADVHAK----DKGGLVPLHNACSYGHYEVAE 576

Query: 274 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 333
            LV H A V++ D   ++ LH+   +G       L+++GA           TPL LV   
Sbjct: 577 LLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG-NTPLDLVK-- 633

Query: 334 SSKKHSADVMSEMAQIAEAL----------LQAGANPNMQDSKGR--TPLHVSIMAGNEY 381
                  D++   A + +A           L +  N N +D++GR  TPLH++    N  
Sbjct: 634 DGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLE 693

Query: 382 VFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAA 441
           V   LLQ    D+  +D  G                        +P+ N  S+       
Sbjct: 694 VAEYLLQ-HGADVNAQDKGGL-----------------------IPLHNAASY------- 722

Query: 442 RLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRH 501
                  H D                     AAL +  N A VN  +KW  TPLH A + 
Sbjct: 723 ------GHVD--------------------VAALLIKYN-ACVNATDKWAFTPLHEAAQK 755

Query: 502 GLANLTAELLQQGANPNLQTEE 523
           G   L A LL  GA+P L+ +E
Sbjct: 756 GRTQLCALLLAHGADPTLKNQE 777



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 46/132 (34%), Positives = 61/132 (46%), Gaps = 2/132 (1%)

Query: 862 SGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEI 921
           S AAE V+   R  L  A +N D+E V  L++    VNSR     K TPLH A   G + 
Sbjct: 15  SAAAEAVEPAARE-LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKD 72

Query: 922 IVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAV 981
           +V  LL  GA V          LH A       + ++LL +G D  A D      LH A 
Sbjct: 73  VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132

Query: 982 MHGRLNNIRVLL 993
           + G+++   VLL
Sbjct: 133 IKGKIDVCIVLL 144


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score =  129 bits (324), Expect = 2e-29
 Identities = 178/748 (23%), Positives = 279/748 (37%), Gaps = 126/748 (16%)

Query: 427  PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNH 486
            P+     F        L+Q G++  A D   G   L  A   G+      L   GA  N 
Sbjct: 219  PLHFAAGFGRKDVVEHLLQMGANVHARDDG-GLIPLHNACSFGHAEVVSLLLCQGADPNA 277

Query: 487  RNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE---ALPLPKEAAS---------- 533
            R+ W  TPLH A   G  ++   LLQ GA+PN++  +   AL L   +A           
Sbjct: 278  RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKD 337

Query: 534  -----------------LTSLADSVHLQ-----TPLHMAIAYNHPDVVSVILEQKANALH 571
                             LT L  + H       TPLH+A  YN   +V ++L+  A+ +H
Sbjct: 338  ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD-VH 396

Query: 572  ATNNLQIIP-------------DFSLKDSRDQTVLGLALWTGMHTIAAQ--------LLG 610
            A +   ++P             +  LK       + L  +T +H  A++        LL 
Sbjct: 397  AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 456

Query: 611  SGAAINDTMSDGQTLLHMA--------IQRQDSKSALFLLEHQAD------------INV 650
             GA        G++ + MA        +  +    +L     +AD            IN 
Sbjct: 457  HGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF 516

Query: 651  SRTQDGETALQLAIRNQLPL---VVDAICTRGADMSVPDEKGNPPLWLALANNLEDIAST 707
             + Q  ETAL  A+ +  P    V + +  +GA+++  ++    PL +A      D+   
Sbjct: 517  KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576

Query: 708  LVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPG-----ANG 762
            L +HG              QT LHRA    +  T   L+  G D +     G        
Sbjct: 577  LHKHGAKMNALDT----LGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGN 632

Query: 763  EGEEEARDGQTPLHL---------AASWGLEETVQCLLEFGANVNAQDAEGR--TPIHVA 811
            E  ++     TP+           A+  G  ETV+ L     NVN +D EGR  TP+H A
Sbjct: 633  EAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFA 691

Query: 812  ISSQHGVIIQLLVSH-PDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN 870
                   +++ L+ H  D+H   +D+ GL P   A ++ + + AE +L R   +    D 
Sbjct: 692  AGYNRVSVVEYLLHHGADVH--AKDKGGLVPLHNACSYGHYEVAE-LLVRHGASVNVADL 748

Query: 871  KGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAG 930
                 LH A      E    L+   A+   + +D +  TPL L  +  ++I         
Sbjct: 749  WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN--TPLDLVKEGDTDI--------- 797

Query: 931  AKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIR 990
                +L +     L  A +  L  +  +     ++        +  LHLA  +  L    
Sbjct: 798  ---QDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAE 854

Query: 991  VLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLL 1050
             LL E   D  A +  G  PLH    YG  + AA+   +  C+     +  D    T L 
Sbjct: 855  YLL-EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-----NATDKWAFTPLH 908

Query: 1051 LAYMKGNANLCRAIVRSGARLGVNNNQG 1078
             A  KG   LC  ++  GA   + N +G
Sbjct: 909  EAAQKGRTQLCALLLAHGADPTMKNQEG 936



 Score =  127 bits (318), Expect = 8e-29
 Identities = 195/850 (22%), Positives = 311/850 (36%), Gaps = 159/850 (18%)

Query: 206 SAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALS 265
           +A +  K +  +   PLH A    R+DVV   L     Q+   ++  D  G + L  A S
Sbjct: 204 AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL-----QMGANVHARDDGGLIPLHNACS 258

Query: 266 RRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQET 325
                + + L+   AD +  D   ++ LH+   +G +     L+++GA  N         
Sbjct: 259 FGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPN--------- 309

Query: 326 PLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQ 385
                           + +   + A  L    A   +     +  L  +  +GNE     
Sbjct: 310 ----------------IRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMA 353

Query: 386 LLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQ 445
           LL    ++    D   ST L LA                         ++       L+Q
Sbjct: 354 LLTPLNVNCHASDGRKSTPLHLA-----------------------AGYNRVRIVQLLLQ 390

Query: 446 RGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLAN 505
            G+   A D   G   L  A   G+      L  +GA VN  + W  TPLH A       
Sbjct: 391 HGADVHAKDKG-GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVE 449

Query: 506 LTAELLQQGANPNL---------------QTEEALPLPKEAASLTSLADSVHL------- 543
           + + LL  GA+P L               +  E L    +  SL   A    L       
Sbjct: 450 VCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTL 509

Query: 544 -------------QTPLHMAIAYNHP---DVVSVILEQKANALHATNNLQIIPDFSLKDS 587
                        +T LH A+A  HP    V  ++L + AN              + K+ 
Sbjct: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV-------------NEKNK 556

Query: 588 RDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQAD 647
              T L +A     + +   L   GA +N   + GQT LH A      ++   LL + +D
Sbjct: 557 DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616

Query: 648 INVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIAST 707
            ++   Q G TA Q+       ++ ++   R +D+          L  + A +LE +   
Sbjct: 617 PSIISLQ-GFTAAQMGNEAVQQILSESTPIRTSDVDY------RLLEASKAGDLETVKQL 669

Query: 708 LVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEE 767
                 +         G   T LH A   N      +L+  G DV++            +
Sbjct: 670 CSSQNVNCR----DLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA------------K 713

Query: 768 ARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHP 827
            + G  PLH A S+G  E  + L+  GA+VN  D    TP+H A +     I +LL+ H 
Sbjct: 714 DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH- 772

Query: 828 DIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV------------------- 868
                 ++R G TP    +  + +   + +L+ ++   +                     
Sbjct: 773 GADPTKKNRDGNTPL--DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830

Query: 869 -DNKGRNF--LHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRN 925
            D +GRN   LH+A   +++E   +L+   A+VN+  QD   L PLH A   G   I   
Sbjct: 831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA--QDKGGLIPLHNAASYGHVDIAAL 888

Query: 926 LLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGR 985
           L+     VN   K   T LH AAQ+    +C++LL +G D    ++ G   L LA     
Sbjct: 889 LIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT---- 944

Query: 986 LNNIRVLLTE 995
            ++IR LL +
Sbjct: 945 ADDIRALLID 954



 Score =  112 bits (279), Expect = 3e-24
 Identities = 136/491 (27%), Positives = 209/491 (42%), Gaps = 68/491 (13%)

Query: 509 ELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKAN 568
           ELL+   N ++   + L    +AA++ +   +    +PLH A  +   DVV  +L+  AN
Sbjct: 185 ELLEACRNGDVSRVKRLV---DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241

Query: 569 ALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHM 628
            +HA ++  +IP            L  A   G   + + LL  GA  N   +   T LH 
Sbjct: 242 -VHARDDGGLIP------------LHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHE 288

Query: 629 AIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEK 688
           A  +      + LL+H AD N+ R  DG++AL LA  +       A+ T        + K
Sbjct: 289 AAIKGKIDVCIVLLQHGADPNI-RNTDGKSALDLADPS-----AKAVLT-------GEYK 335

Query: 689 GNPPLWLALANNLEDIASTL--VRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLI 746
            +  L  A + N E + + L  +   C A+       G   T LH A   N       L+
Sbjct: 336 KDELLEAARSGNEEKLMALLTPLNVNCHAS------DGRKSTPLHLAAGYNRVRIVQLLL 389

Query: 747 RSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRT 806
           + G DV++            + + G  PLH A S+G  E  + LL+ GA VNA D    T
Sbjct: 390 QHGADVHA------------KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFT 437

Query: 807 PIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAE 866
           P+H A S     +  LL+SH           G  P    +      + +     E     
Sbjct: 438 PLHEAASKNRVEVCSLLLSH-----------GADP--TLVNCHGKSAVDMAPTPELRERL 484

Query: 867 QVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQA---GSEIIV 923
             + KG + L  A + +D+  V   +++   +N + Q  S  T LH AV +     + + 
Sbjct: 485 TYEFKGHSLLQ-AAREADLAKVKKTLALEI-INFK-QPQSHETALHCAVASLHPKRKQVT 541

Query: 924 RNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMH 983
             LL  GA VNE  K   T LH+AA++    +  VL ++G    A+D  G  ALH A + 
Sbjct: 542 ELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALA 601

Query: 984 GRLNNIRVLLT 994
           G L   R+LL+
Sbjct: 602 GHLQTCRLLLS 612



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 94/318 (29%), Positives = 131/318 (41%), Gaps = 45/318 (14%)

Query: 719  GPGPG-----GCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQ--PGANGEGEEEARDG 771
            GPG G     G L+ LL           AC   R+G DV+  ++    AN   ++ A   
Sbjct: 171  GPGTGVPAVSGALRELLE----------AC---RNG-DVSRVKRLVDAANVNAKDMAGRK 216

Query: 772  QTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL 831
             +PLH AA +G ++ V+ LL+ GANV+A+D  G  P+H A S  H  ++ LL+       
Sbjct: 217  SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ-GADP 275

Query: 832  NVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN-KGRNFLHVA----------- 879
            N RD    TP   A      K    I+  + GA   + N  G++ L +A           
Sbjct: 276  NARDNWNYTPLHEAAI--KGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGE 333

Query: 880  --------VQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGA 931
                       S  E  L  +    NVN    D  K TPLHLA       IV+ LL  GA
Sbjct: 334  YKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGA 393

Query: 932  KVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRV 991
             V+   K     LH A       +  +LL++G    A+D      LH A    R+    +
Sbjct: 394  DVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 453

Query: 992  LLTECTVDAEAFNLRGQS 1009
            LL+    D    N  G+S
Sbjct: 454  LLSH-GADPTLVNCHGKS 470



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 113/469 (24%), Positives = 183/469 (39%), Gaps = 44/469 (9%)

Query: 263 ALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA-TLG 321
           +L  + + +   L+   A+V+  +K   + LH   +R        L K+GA +NA  TLG
Sbjct: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591

Query: 322 AQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEY 381
             +T LH  AL               Q    LL  G++P++   +G T   +    GNE 
Sbjct: 592 --QTALHRAALAGH-----------LQTCRLLLSYGSDPSIISLQGFTAAQM----GNEA 634

Query: 382 V---FSQLLQCKQLDLELKDHEGSTALWL-AVQHITVSSDQSVNPFE---DVPVVNGTSF 434
           V    S+    +  D++ +  E S A  L  V+ +  S + +    E     P+     +
Sbjct: 635 VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGY 694

Query: 435 DENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETP 494
           +  S    L+  G+   A D   G   L  A   G+   A  L  +GA VN  + W  TP
Sbjct: 695 NRVSVVEYLLHHGADVHAKDKG-GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753

Query: 495 LHTACRHGLANLTAELLQQGANPNLQTEEA-LPLPKEAASLTSLADSVHLQTPLHMAIAY 553
           LH A   G   +   LL+ GA+P  +  +   PL       T + D +     L  A   
Sbjct: 754 LHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAA-- 811

Query: 554 NHPDVVSVILEQKANALHATNNLQIIPDFSLKDS--RDQTVLGLALWTGMHTIAAQLLGS 611
                       K   L     L    + + +D+  R+ T L LA       +A  LL  
Sbjct: 812 ------------KKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEH 859

Query: 612 GAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLV 671
           GA +N     G   LH A        A  L+++   +N +  +   T L  A +     +
Sbjct: 860 GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT-DKWAFTPLHEAAQKGRTQL 918

Query: 672 VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP 720
              +   GAD ++ +++G  PL LA A+++  +    +      TC+ P
Sbjct: 919 CALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKP 967



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 92/357 (25%), Positives = 139/357 (38%), Gaps = 60/357 (16%)

Query: 214 IKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIAT 273
           ++ +   PLH A    R  VV  YL+   + +  K    D  G + L  A S     +A 
Sbjct: 680 LEGRHSTPLHFAAGYNRVSVVE-YLLHHGADVHAK----DKGGLVPLHNACSYGHYEVAE 734

Query: 274 TLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALY 333
            LV H A V++ D   ++ LH+   +G       L+K+GA           TPL LV   
Sbjct: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDG-NTPLDLV--- 790

Query: 334 SSKKHSADVMSEMAQIAEALLQAG--------------ANPNMQDSKGR--TPLHVSIMA 377
             K+   D+  ++ +   ALL A                N N +D++GR  TPLH++   
Sbjct: 791 --KEGDTDI-QDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847

Query: 378 GNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDEN 437
            N  V   LL+    D+  +D  G                        +P+ N  S+   
Sbjct: 848 NNLEVAEYLLE-HGADVNAQDKGGL-----------------------IPLHNAASYGHV 883

Query: 438 SFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHT 497
             AA LI+  +  +A D      L + A     +  AL LA +GA    +N+ G+TPL  
Sbjct: 884 DIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA-HGADPTMKNQEGQTPLDL 942

Query: 498 ACRHGLANLTAELLQQGANPNLQTEEA------LPLPKEAASLTSLADSV-HLQTPL 547
           A    +  L  + +   A P     +A      L  P    S  S A S+ +L  PL
Sbjct: 943 ATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPL 999


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
            sapiens]
          Length = 765

 Score =  124 bits (312), Expect = 4e-28
 Identities = 128/450 (28%), Positives = 201/450 (44%), Gaps = 45/450 (10%)

Query: 659  ALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCW 718
            ALQL+ R  L         R  ++ + + K  P  +L    ++E +   L+ H  D  C 
Sbjct: 340  ALQLSDRKNL-------VPRDEELCIYENKVTPLHFLVAQGSVEQVR-LLLAHEVDVDCQ 391

Query: 719  GPGPGGCLQTLLHRAIDENNEPTAC-FLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHL 777
                      LL  A D+  +P  C  L+  G D N   +            DG  PLH 
Sbjct: 392  ---TASGYTPLLIAAQDQ--QPDLCALLLAHGADANRVDE------------DGWAPLHF 434

Query: 778  AASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQ 837
            AA  G + T + LL+ GA V+AQ+ EG TP+H+A  +    + +LLVS      N+ + +
Sbjct: 435  AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR-QADPNLHEAE 493

Query: 838  GLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNF---LHVAVQNSDIESVLFLISV 894
            G TP   A  F +     +++K  +    ++D + RN    LH+AV+   + ++  L+  
Sbjct: 494  GKTPLHVAAYFGH----VSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 895  HANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPT 954
             A  ++   D S   PLH A   G  +I + LL  GA +   T    T LHLAA +    
Sbjct: 550  GAVPDAL--DQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607

Query: 955  ICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHIL 1014
            I  +L E+  +  A+       LHLA  HG    +  LL +C  D  A    G +PLH+ 
Sbjct: 608  IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL-QCGADPNAAEQSGWTPLHLA 666

Query: 1015 GQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVN 1074
             Q  +    ++ +L       +  +K    G T   LA +KGN  + + +V +GA+L V 
Sbjct: 667  VQ--RSTFLSVINLLEHHANVHARNKV---GWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721

Query: 1075 NNQGVNIFNYQVATKQLLFRLLDML-SKEP 1103
            +  GV+    Q+A +     ++  L  KEP
Sbjct: 722  D--GVSCTPLQLALRSRKQGIMSFLEGKEP 749



 Score =  121 bits (303), Expect = 4e-27
 Identities = 122/439 (27%), Positives = 181/439 (41%), Gaps = 43/439 (9%)

Query: 620  SDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRG 679
            SD    L  A+Q  D K+ +       D  +   ++  T L   +       V  +    
Sbjct: 331  SDSGNYLKRALQLSDRKNLV-----PRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHE 385

Query: 680  ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATC-----WGPGPGGCLQTLLHRAI 734
             D+      G  PL +A  +   D+ + L+ HG DA       W P         LH A 
Sbjct: 386  VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP---------LHFAA 436

Query: 735  DENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFG 794
               ++ TA  L+  G  V++            + R+G TPLHLAA    E   + L+   
Sbjct: 437  QNGDDGTARLLLDHGACVDA------------QEREGWTPLHLAAQNNFENVARLLVSRQ 484

Query: 795  ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSA 854
            A+ N  +AEG+TP+HVA    H  +++LL S     L+ + R   TP   A+     ++ 
Sbjct: 485  ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ-GAELDAQQRNLRTPLHLAVERGKVRAI 543

Query: 855  EAILKRESGAA-EQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHL 913
            + +LK  SGA  + +D  G   LH A           L+   A++          TPLHL
Sbjct: 544  QHLLK--SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG--WTPLHL 599

Query: 914  AVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENG 973
            A   G   I+  L  + A +  L     T LHLAA+     + S LL+ G D  A +++G
Sbjct: 600  AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 974  NNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECM 1033
               LHLAV      ++ + L E   +  A N  G +P H+    G     AI  + +E  
Sbjct: 660  WTPLHLAVQRSTFLSV-INLLEHHANVHARNKVGWTPAHLAALKGN---TAILKVLVEA- 714

Query: 1034 PGYPLDKPDADGSTVLLLA 1052
             G  LD  D    T L LA
Sbjct: 715  -GAQLDVQDGVSCTPLQLA 732



 Score =  119 bits (298), Expect = 2e-26
 Identities = 119/418 (28%), Positives = 180/418 (43%), Gaps = 40/418 (9%)

Query: 545 TPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTI 604
           TPLH  +A    + V ++L  +              D   + +   T L +A       +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEV-------------DVDCQTASGYTPLLIAAQDQQPDL 410

Query: 605 AAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAI 664
            A LL  GA  N    DG   LH A Q  D  +A  LL+H A ++ ++ ++G T L LA 
Sbjct: 411 CALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVD-AQEREGWTPLHLAA 469

Query: 665 RNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGG 724
           +N    V   + +R AD ++ + +G  PL +A       +   L   G +          
Sbjct: 470 QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRN--- 526

Query: 725 CLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLE 784
            L+T LH A++         L++SG   ++  Q G              PLH AA+ G  
Sbjct: 527 -LRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYG------------PLHTAAARGKY 573

Query: 785 ETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV-SHPDIHLNVRDRQGLTPFA 843
              + LL +GA++     +G TP+H+A    H  II LL  SH +  +        TP  
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHAN--MGALGAVNWTPLH 631

Query: 844 CAMTFKNNKSAEAILK--RESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
            A          A+L+   +  AAEQ    G   LH+AVQ S   SV+ L+  HANV++R
Sbjct: 632 LAARHGEEAVVSALLQCGADPNAAEQ---SGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688

Query: 902 VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
             +    TP HLA   G+  I++ L+ AGA+++       T L LA +     I S L
Sbjct: 689 --NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  108 bits (269), Expect = 4e-23
 Identities = 108/384 (28%), Positives = 157/384 (40%), Gaps = 40/384 (10%)

Query: 624 TLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMS 683
           T LH  + +   +    LL H+ D++  +T  G T L +A ++Q P +   +   GAD +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDC-QTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 684 VPDEKGNPPLWLALANNLEDIASTLVRHGC-----DATCWGPGPGGCLQTLLHRAIDENN 738
             DE G  PL  A  N  +  A  L+ HG      +   W P         LH A   N 
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP---------LHLAAQNNF 473

Query: 739 EPTACFLIRSGCDVNSPRQPGAN---------------------GEGEEEARDGQTPLHL 777
           E  A  L+    D N     G                        E + + R+ +TPLHL
Sbjct: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533

Query: 778 AASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQ 837
           A   G    +Q LL+ GA  +A D  G  P+H A +    +I ++L+ +    L +   Q
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY-GASLELPTHQ 592

Query: 838 GLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHAN 897
           G TP   A  +K +     +L         +       LH+A ++ +   V  L+   A+
Sbjct: 593 GWTPLHLA-AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD 651

Query: 898 VNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICS 957
            N+  Q  S  TPLHLAVQ  + + V NLL   A V+   K   T  HLAA +    I  
Sbjct: 652 PNAAEQ--SGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILK 709

Query: 958 VLLENGVDFAAVDENGNNALHLAV 981
           VL+E G      D      L LA+
Sbjct: 710 VLVEAGAQLDVQDGVSCTPLQLAL 733



 Score =  104 bits (259), Expect = 6e-22
 Identities = 124/452 (27%), Positives = 174/452 (38%), Gaps = 75/452 (16%)

Query: 275 LVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYS 334
           L++H+ DVD    SG++ L    Q         L+ +GA  N         PLH  A   
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW-APLHFAAQNG 439

Query: 335 SKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDL 394
                          A  LL  GA  + Q+ +G TPLH++     E V ++LL  +Q D 
Sbjct: 440 DDG-----------TARLLLDHGACVDAQEREGWTPLHLAAQNNFENV-ARLLVSRQADP 487

Query: 395 ELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPD 454
            L + EG T L +A                         F   S    L  +G+  DA  
Sbjct: 488 NLHEAEGKTPLHVAAY-----------------------FGHVSLVKLLTSQGAELDAQQ 524

Query: 455 TATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG 514
                  L  A   G   A   L  +GA  +  ++ G  PLHTA   G   +   LL+ G
Sbjct: 525 RNL-RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG 583

Query: 515 ANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKAN--ALHA 572
           A+  L T +                     TPLH+A    H +++ ++ E  AN  AL A
Sbjct: 584 ASLELPTHQGW-------------------TPLHLAAYKGHLEIIHLLAESHANMGALGA 624

Query: 573 TNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQR 632
            N                T L LA   G   + + LL  GA  N     G T LH+A+QR
Sbjct: 625 VN---------------WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 633 QDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPP 692
               S + LLEH A+++ +R + G T   LA       ++  +   GA + V D     P
Sbjct: 670 STFLSVINLLEHHANVH-ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728

Query: 693 LWLALANNLEDIASTLV-RHGCDATCWGPGPG 723
           L LAL +  + I S L  +    AT  G  PG
Sbjct: 729 LQLALRSRKQGIMSFLEGKEPSVATLGGSKPG 760



 Score =  100 bits (250), Expect = 6e-21
 Identities = 104/377 (27%), Positives = 166/377 (44%), Gaps = 63/377 (16%)

Query: 221 PLHKAI---KVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVS 277
           PLH  +    VE+  ++  + +++D Q          +G   L +A   +   +   L++
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTA--------SGYTPLLIAAQDQQPDLCALLLA 416

Query: 278 HKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKK 337
           H AD + VD+ GW+ LH   Q GD   A  L+ +GA V+A       TPLHL A      
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGW-TPLHLAA------ 469

Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
                 +    +A  L+   A+PN+ +++G+TPLHV+   G+  +  +LL  +  +L+ +
Sbjct: 470 -----QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV-KLLTSQGAELDAQ 523

Query: 398 DHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSF------AAR--------L 443
                T L LAV+   V + Q +     VP     + D++ +      AAR        L
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVP----DALDQSGYGPLHTAAARGKYLICKML 579

Query: 444 IQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGL 503
           ++ G+  + P T  G   L  AA  G+      LA + A++        TPLH A RHG 
Sbjct: 580 LRYGASLELP-THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638

Query: 504 ANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVIL 563
             + + LLQ GA+PN   +                      TPLH+A+  +    V  +L
Sbjct: 639 EAVVSALLQCGADPNAAEQSG-------------------WTPLHLAVQRSTFLSVINLL 679

Query: 564 EQKANALHATNNLQIIP 580
           E  AN +HA N +   P
Sbjct: 680 EHHAN-VHARNKVGWTP 695



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 117/461 (25%), Positives = 180/461 (39%), Gaps = 86/461 (18%)

Query: 369 TPLHVSIMAGN-EYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVP 427
           TPLH  +  G+ E V  +LL   ++D++ +   G T L +A Q      DQ         
Sbjct: 364 TPLHFLVAQGSVEQV--RLLLAHEVDVDCQTASGYTPLLIAAQ------DQ--------- 406

Query: 428 VVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHR 487
                   +    A L+  G+  +  D   G   L  AA  G++  A  L  +GA V+ +
Sbjct: 407 --------QPDLCALLLAHGADANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457

Query: 488 NKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPL 547
            + G TPLH A ++   N+   L+ + A+PNL   E                    +TPL
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG-------------------KTPL 498

Query: 548 HMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ 607
           H+A  + H  +V ++  Q A       NL+             T L LA+  G       
Sbjct: 499 HVAAYFGHVSLVKLLTSQGAELDAQQRNLR-------------TPLHLAVERGKVRAIQH 545

Query: 608 LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
           LL SGA  +     G   LH A  R        LL + A + +  T  G T L LA    
Sbjct: 546 LLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP-THQGWTPLHLAAYKG 604

Query: 668 LPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATC-----WGPGP 722
              ++  +    A+M         PL LA  +  E + S L++ G D        W P  
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP-- 662

Query: 723 GGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWG 782
                  LH A+  +   +   L+    +V++  + G             TP HLAA  G
Sbjct: 663 -------LHLAVQRSTFLSVINLLEHHANVHARNKVG------------WTPAHLAALKG 703

Query: 783 LEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLL 823
               ++ L+E GA ++ QD    TP+ +A+ S+   I+  L
Sbjct: 704 NTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 68/215 (31%), Positives = 104/215 (48%), Gaps = 20/215 (9%)

Query: 861  ESGAAEQVDNKGRNFLHVAVQNSDIESVLFL---ISVHANVNSRVQDASKLTPLHLAVQA 917
            E  + E +D+   N+L  A+Q SD ++++     + ++ N         K+TPLH  V  
Sbjct: 322  EDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYEN---------KVTPLHFLVAQ 372

Query: 918  GSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNAL 977
            GS   VR LL     V+  T    T L +AAQ   P +C++LL +G D   VDE+G   L
Sbjct: 373  GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432

Query: 978  HLAVMHGRLNNIRVLLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGY 1036
            H A  +G     R+LL     VDA+     G +PLH+  Q   EN A +  +  +  P  
Sbjct: 433  HFAAQNGDDGTARLLLDHGACVDAQ--EREGWTPLHLAAQNNFENVARLL-VSRQADP-- 487

Query: 1037 PLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARL 1071
              +  +A+G T L +A   G+ +L + +   GA L
Sbjct: 488  --NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  112 bits (279), Expect = 3e-24
 Identities = 102/398 (25%), Positives = 155/398 (38%), Gaps = 88/398 (22%)

Query: 619  MSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTR 678
            +  G +LLH+A++    + A +LL + A+ N+S  + G T L +A+  ++  VV+ +  R
Sbjct: 435  LDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRR-GSTPLHMAVERRVRGVVELLLAR 493

Query: 679  GADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENN 738
               ++  DE                              W         T LH A    +
Sbjct: 494  KISVNAKDEDQ----------------------------W---------TALHFAAQNGD 516

Query: 739  EPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVN 798
            E +   L+     VN            E   +G+TP+H+A   G E  V+ LL  G +V+
Sbjct: 517  ESSTRLLLEKNASVN------------EVDFEGRTPMHVACQHGQENIVRILLRRGVDVS 564

Query: 799  AQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAIL 858
             Q  +   P+H A    H  I++LL   P + +N +   G TP                 
Sbjct: 565  LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTP----------------- 607

Query: 859  KRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG 918
                             LH+A Q         LI + ++VN  V      TPLH+A + G
Sbjct: 608  -----------------LHLAAQRGHYRVARILIDLCSDVN--VCSLLAQTPLHVAAETG 648

Query: 919  SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH 978
                 R LL  GA    +T    TALHLAA+        +L+E   D  A       ALH
Sbjct: 649  HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALH 708

Query: 979  LAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQ 1016
            LA  HG    +  L++   +D   F+ +G S LH+  Q
Sbjct: 709  LAAAHGHSEVVEELVSADVID--LFDEQGLSALHLAAQ 744



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 124/496 (25%), Positives = 194/496 (39%), Gaps = 116/496 (23%)

Query: 256 GDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFV 315
           G L+L          + TT V  K  VD +     S L K +Q  D+  A   + +GA +
Sbjct: 385 GSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLA---LDSGASL 441

Query: 316 NAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSI 375
                      LHL            V +   + A+ LL   ANPN+ + +G TPLH+++
Sbjct: 442 -----------LHLA-----------VEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479

Query: 376 MAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFD 435
                 V  +LL  +++ +  K                                     D
Sbjct: 480 ERRVRGVV-ELLLARKISVNAK-------------------------------------D 501

Query: 436 ENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPL 495
           E+ + A                    L  AA  G+E++   L    A VN  +  G TP+
Sbjct: 502 EDQWTA--------------------LHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPM 541

Query: 496 HTACRHGLANLTAELLQQGANPNLQTEEA------------LPLPKEAASLTSL---ADS 540
           H AC+HG  N+   LL++G + +LQ ++A            LP+ K  A    +   A +
Sbjct: 542 HVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQT 601

Query: 541 VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600
           +  +TPLH+A    H  V  ++++             +  D ++     QT L +A  TG
Sbjct: 602 LDGRTPLHLAAQRGHYRVARILID-------------LCSDVNVCSLLAQTPLHVAAETG 648

Query: 601 MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660
             + A  LL  GA      SDG T LH+A +     +   L+E +AD+ ++R    +TAL
Sbjct: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADV-LARGPLNQTAL 707

Query: 661 QLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWG- 719
            LA  +    VV+ + +    + + DE+G   L LA          TL+RHG        
Sbjct: 708 HLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766

Query: 720 --PGPGGCLQTLLHRA 733
              G  G   TLL R+
Sbjct: 767 KFQGGHGPAATLLRRS 782



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 103/413 (24%), Positives = 160/413 (38%), Gaps = 50/413 (12%)

Query: 404 ALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQ 463
           +L L+ +    +SD      +   +V+     + S   +++Q      A D+  G  LL 
Sbjct: 386 SLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLH 443

Query: 464 RAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE 523
            A  AG E  A +L  N A+ N  N+ G TPLH A    +  +   LL +  + N + E+
Sbjct: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED 503

Query: 524 -------ALPLPKEAASLTSLADSVHL-------QTPLHMAIAYNHPDVVSVILEQKANA 569
                  A     E+++   L  +  +       +TP+H+A  +   ++V ++L +    
Sbjct: 504 QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGV-- 561

Query: 570 LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGS--GAAINDTMSDGQTLLH 627
                      D SL+       L  A W G H    +LL    G ++N    DG+T LH
Sbjct: 562 -----------DVSLQGKDAWLPLHYAAWQG-HLPIVKLLAKQPGVSVNAQTLDGRTPLH 609

Query: 628 MAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDE 687
           +A QR   + A  L++  +D+NV      +T L +A           +  RGA       
Sbjct: 610 LAAQRGHYRVARILIDLCSDVNVCSLL-AQTPLHVAAETGHTSTARLLLHRGAGKEAMTS 668

Query: 688 KGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIR 747
            G   L LA  N        LV    D    GP      QT LH A    +      L+ 
Sbjct: 669 DGYTALHLAARNGHLATVKLLVEEKADVLARGP----LNQTALHLAAAHGHSEVVEELVS 724

Query: 748 SGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQ 800
           +        Q             G + LHLAA     +TV+ LL  GA++N Q
Sbjct: 725 ADVIDLFDEQ-------------GLSALHLAAQGRHAQTVETLLRHGAHINLQ 764



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 85/357 (23%), Positives = 141/357 (39%), Gaps = 48/357 (13%)

Query: 222 LHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKAD 281
           LH A++  +E+     L+   +      N ++  G   L +A+ RR+  +   L++ K  
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANP-----NLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496

Query: 282 VDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSAD 341
           V+  D+  W+ LH   Q GD  +   L++  A VN      + TP+H+   +  +     
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR-TPMHVACQHGQE----- 550

Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
                  I   LL+ G + ++Q      PLH +   G+  +   L +   + +  +  +G
Sbjct: 551 ------NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDG 604

Query: 402 STALWLAVQH---------ITVSSDQSV-NPFEDVPVVNGTSFDENSFAARLIQRGSHTD 451
            T L LA Q          I + SD +V +     P+         S A  L+ RG+  +
Sbjct: 605 RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 664

Query: 452 APDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELL 511
           A  T+ G   L  AA  G+ A    L    A V  R    +T LH A  HG + +  EL+
Sbjct: 665 AM-TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV 723

Query: 512 QQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKAN 568
                              +A +  L D   L + LH+A    H   V  +L   A+
Sbjct: 724 -------------------SADVIDLFDEQGL-SALHLAAQGRHAQTVETLLRHGAH 760



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 60/196 (30%), Positives = 88/196 (44%), Gaps = 7/196 (3%)

Query: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
            + G + LH+AV+    E   +L+  +AN N   +  S  TPLH+AV+     +V  LL  
Sbjct: 436  DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGS--TPLHMAVERRVRGVVELLLAR 493

Query: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
               VN   + + TALH AAQ    +   +LLE       VD  G   +H+A  HG+ N +
Sbjct: 494  KISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553

Query: 990  RVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVL 1049
            R+LL    VD          PLH     G      +    L   PG  ++    DG T L
Sbjct: 554  RILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKL----LAKQPGVSVNAQTLDGRTPL 608

Query: 1050 LLAYMKGNANLCRAIV 1065
             LA  +G+  + R ++
Sbjct: 609  HLAAQRGHYRVARILI 624



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 69/242 (28%), Positives = 109/242 (45%), Gaps = 15/242 (6%)

Query: 869  DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLL 928
            + +G   LH+AV+      V  L++   +VN++ +D  + T LH A Q G E   R LL 
Sbjct: 468  NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED--QWTALHFAAQNGDESSTRLLLE 525

Query: 929  AGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNN 988
              A VNE+    +T +H+A Q     I  +LL  GVD +   ++    LH A   G L  
Sbjct: 526  KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPI 585

Query: 989  IRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAI-FDLFLECMPGYPLDKPDADGST 1047
            +++L  +  V   A  L G++PLH+  Q G    A I  DL  +      ++       T
Sbjct: 586  VKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD------VNVCSLLAQT 639

Query: 1048 VLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIF-----NYQVATKQLLF-RLLDMLSK 1101
             L +A   G+ +  R ++  GA      + G         N  +AT +LL     D+L++
Sbjct: 640  PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699

Query: 1102 EP 1103
             P
Sbjct: 700  GP 701


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  111 bits (278), Expect = 4e-24
 Identities = 133/618 (21%), Positives = 237/618 (38%), Gaps = 125/618 (20%)

Query: 327 LHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQL 386
           LH +  Y +      V     +  + LL  GANPN+++     PLH+++   N  V   L
Sbjct: 91  LHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVL 150

Query: 387 LQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQR 446
           L+ + +D+ L+   G+TA+ +A                            NS A +++ +
Sbjct: 151 LEHRTIDVNLEGENGNTAVIIACT------------------------TNNSEALQILLK 186

Query: 447 GSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNG--------AHVNHRNKWGETPLHTA 498
                      G   + +AA +G++     +   G         H+N  N    TPLH A
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246

Query: 499 CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDV 558
            ++G   +    L  GA  +       P+ K               T +H A      ++
Sbjct: 247 VQNGDLEMIKMCLDNGAQID-------PVEKGRC------------TAIHFAATQGATEI 287

Query: 559 VSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDT 618
           V +++   + ++   N           D   +T+L  A     H +A  L+  GA IN  
Sbjct: 288 VKLMISSYSGSVDIVNT---------TDGCHETMLHRASLFDHHELADYLISVGADINKI 338

Query: 619 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTR 678
            S+G             +S L L    A  N                     +V+ + ++
Sbjct: 339 DSEG-------------RSPLILATASASWN---------------------IVNLLLSK 364

Query: 679 GADMSVPDEKGNPPLWLALAN--NLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDE 736
           GA + + D  G   L L +     L+++    ++               +Q +    +DE
Sbjct: 365 GAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQ---------------MQQIKELVMDE 409

Query: 737 NNEPTACFLIRSGCDVNSPRQP----GANGEGEEEARDGQTPLHLAASWGLEETVQCLLE 792
           +N+   C  +   C    P       G N     +++D ++PLH AAS+G   T Q LL+
Sbjct: 410 DND--GCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQ 467

Query: 793 FGAN---VNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFK 849
             ++   +N  D  G TP+H+A  + H  ++QLL+    + L+  D  G T    A    
Sbjct: 468 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLS--DHNGWTALHHASMGG 525

Query: 850 NNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLT 909
             ++ + IL       +++D  G   LH A +    ++V  L+S +A++    Q AS   
Sbjct: 526 YTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASF-- 583

Query: 910 PLHLAVQAGSEIIVRNLL 927
            LHLA+    + +V  ++
Sbjct: 584 -LHLALHNKRKEVVLTII 600



 Score =  108 bits (271), Expect = 2e-23
 Identities = 124/504 (24%), Positives = 208/504 (41%), Gaps = 69/504 (13%)

Query: 622  GQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICT-RGA 680
            G T LH A+++   +S  FLL   A+ N+ R  +    L +A++     V+  +   R  
Sbjct: 98   GNTPLHCAVEKNQIESVKFLLSRGANPNL-RNFNMMAPLHIAVQGMNNEVMKVLLEHRTI 156

Query: 681  DMSVPDEKGNPPLWLALANNLEDIASTLVRHG---CDATCWGPGPGGCLQTLLHRAIDEN 737
            D+++  E GN  + +A   N  +    L++ G   C +  WG  P       +H+A    
Sbjct: 157  DVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFP-------IHQAAFSG 209

Query: 738  NEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANV 797
            ++     ++R G +    RQ   N     +A    TPLHLA   G  E ++  L+ GA +
Sbjct: 210  SKECMEIILRFGEEHGYSRQLHINFMNNGKA----TPLHLAVQNGDLEMIKMCLDNGAQI 265

Query: 798  NAQDAEGRTPIHVAISSQHGVIIQLLVS---------------------------HPDI- 829
            +  +    T IH A +     I++L++S                           H ++ 
Sbjct: 266  DPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELA 325

Query: 830  --------HLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV-DNKGRNFLHVAV 880
                     +N  D +G +P   A    +      +L +  GA   + DN GRNFLH+ V
Sbjct: 326  DYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSK--GAQVDIKDNFGRNFLHLTV 383

Query: 881  QNS-DIESVLFLISVHANVNSRVQDASK--LTPLHLAVQAGSEIIVRNLLLAGAKVNELT 937
            Q    ++++         +   V D      TPLH A + G    V NLL     ++  +
Sbjct: 384  QQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS 443

Query: 938  KHRQTALHLAAQQDLPTICSVLLENGVDFAAVDE---NGNNALHLAVMHGRLNNIRVLLT 994
            K +++ LH AA       C  LL++  D   ++E   +G   LHLA  +G    +++LL 
Sbjct: 444  KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLK 503

Query: 995  ECTVDAEAFNLRGQSPLHILGQYG-KENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAY 1053
            +  +     N  G + LH     G  +    I D  L+C      D+ D DG+T L  A 
Sbjct: 504  KGALFLSDHN--GWTALHHASMGGYTQTMKVILDTNLKC-----TDRLDEDGNTALHFAA 556

Query: 1054 MKGNANLCRAIVRSGARLGVNNNQ 1077
             +G+A     ++   A + +N  Q
Sbjct: 557  REGHAKAVALLLSHNADIVLNKQQ 580



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 156/665 (23%), Positives = 249/665 (37%), Gaps = 137/665 (20%)

Query: 24  QKKLAETEKRCALLAAQANKESSSESFISRLLAIVAD-----LYEQEQYSD--LKIKVGD 76
           QKKL    KRC  +       +++E  I  +  I  D     L+E + Y +  L   V  
Sbjct: 53  QKKL----KRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEK 108

Query: 77  RHISAHKFVLAARSDSWSLANLSSTKELDLS--DANPEVTMTMLRWIYTD-ELEFREDDV 133
             I + KF+L+ R  + +L N +    L ++    N EV   +L     D  LE    + 
Sbjct: 109 NQIESVKFLLS-RGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNT 167

Query: 134 FLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASH 193
            +       N   LQ+L ++  K   S  N   C   +Q A   +       C EII   
Sbjct: 168 AVIIACTTNNSEALQILLKKGAKPCKS--NKWGCFPIHQAAFSGSKE-----CMEII--- 217

Query: 194 WDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEAD 253
              LR  +    S QL    + +    PLH A++                          
Sbjct: 218 ---LRFGEEHGYSRQLHINFMNNGKATPLHLAVQ-------------------------- 248

Query: 254 HNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGA 313
            NGDL +               + + A +D V+K   + +H    +G       +I + +
Sbjct: 249 -NGDLEM-----------IKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYS 296

Query: 314 ----FVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRT 369
                VN  T G  ET LH  +L+              ++A+ L+  GA+ N  DS+GR+
Sbjct: 297 GSVDIVNT-TDGCHETMLHRASLFDHH-----------ELADYLISVGADINKIDSEGRS 344

Query: 370 PLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNP-FEDVPV 428
           PL ++  + +  + + LL  K   +++KD+ G   L L VQ       +++ P F  +  
Sbjct: 345 PLILATASASWNIVNLLLS-KGAQVDIKDNFGRNFLHLTVQQ--PYGLKNLRPEFMQMQQ 401

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
           +     DE++                   G   L  A   G   +   L      ++ ++
Sbjct: 402 IKELVMDEDN------------------DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKS 443

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
           K  ++PLH A  +G  N    LLQ  ++  L  E  L                H  TPLH
Sbjct: 444 KDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL----------------HGMTPLH 487

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQL 608
           +A    H  VV ++L++ A                L D    T L  A   G       +
Sbjct: 488 LAAKNGHDKVVQLLLKKGA--------------LFLSDHNGWTALHHASMGGYTQTMKVI 533

Query: 609 LGSGAAINDTMS-DGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQ 667
           L +     D +  DG T LH A +   +K+   LL H ADI +++ Q   + L LA+ N+
Sbjct: 534 LDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQ--ASFLHLALHNK 591

Query: 668 LPLVV 672
              VV
Sbjct: 592 RKEVV 596



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 51/210 (24%), Positives = 92/210 (43%), Gaps = 17/210 (8%)

Query: 867  QVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNL 926
            ++D+ G   LH AV+ + IESV FL+S  AN N R  + + + PLH+AVQ  +  +++ L
Sbjct: 93   EMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR--NFNMMAPLHIAVQGMNNEVMKVL 150

Query: 927  L-LAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGR 985
            L      VN   ++  TA+ +A   +      +LL+ G      ++ G   +H A   G 
Sbjct: 151  LEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGS 210

Query: 986  LNNIRVLLT-------ECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMP-GYP 1037
               + ++L           +     N    +PLH+  Q G        ++   C+  G  
Sbjct: 211  KECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGD------LEMIKMCLDNGAQ 264

Query: 1038 LDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067
            +D  +    T +  A  +G   + + ++ S
Sbjct: 265  IDPVEKGRCTAIHFAATQGATEIVKLMISS 294



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 35/156 (22%), Positives = 56/156 (35%), Gaps = 5/156 (3%)

Query: 933  VNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVL 992
            ++E+  +  T LH A +++       LL  G +    + N    LH+AV       ++VL
Sbjct: 91   LHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVL 150

Query: 993  LTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLA 1052
            L   T+D       G + + I        A  I         G    K +  G   +  A
Sbjct: 151  LEHRTIDVNLEGENGNTAVIIACTTNNSEALQIL-----LKKGAKPCKSNKWGCFPIHQA 205

Query: 1053 YMKGNANLCRAIVRSGARLGVNNNQGVNIFNYQVAT 1088
               G+      I+R G   G +    +N  N   AT
Sbjct: 206  AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKAT 241


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 103/402 (25%), Positives = 176/402 (43%), Gaps = 52/402 (12%)

Query: 443 LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502
           LI+ G++ +  D      L+  A+  G+      L   G ++ HR+  G T L  AC  G
Sbjct: 57  LIKNGANCNLEDLDNWTALIS-ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKG 115

Query: 503 LANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562
             ++   LL  GANP               S+T L  SV+   P+  A    H D+V ++
Sbjct: 116 RTDVVELLLSHGANP---------------SVTGLY-SVY---PIIWAAGRGHADIVHLL 156

Query: 563 LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG 622
           L+  A               +  D    T L  A   G       LL  GA ++   ++ 
Sbjct: 157 LQNGAKV-------------NCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203

Query: 623 QTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADM 682
            T L +A++   ++S   +L+   ++N++  +DG TAL +A +     +V  +   G  +
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLT-DKDGNTALMIASKEGHTEIVQDLLDAGTYV 262

Query: 683 SVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTA 742
           ++PD  G+  L  A+     +I   L++   D    G       +T L+ A+++ N    
Sbjct: 263 NIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN----KTALYWAVEKGNATMV 318

Query: 743 CFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDA 802
             +++             N + E   +DG+TPL  A      E V+ LL+ GA V+A D 
Sbjct: 319 RDILQ------------CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366

Query: 803 EGRTPIHVAISSQHGVIIQLLVSHP-DIHLNVR-DRQGLTPF 842
           +G TP+H+AI  +   + +LL+ +P D  L  R ++ G TP+
Sbjct: 367 KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPY 408



 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 121/475 (25%), Positives = 191/475 (40%), Gaps = 66/475 (13%)

Query: 558  VVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAIND 617
            V++ + E+   AL A   L+   D   ++   QT L +A   G   I  +L+ +GA  N 
Sbjct: 9    VINYVEEENIPALKAL--LEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNL 66

Query: 618  TMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICT 677
               D  T L  A +         LL+   ++   R   G TAL  A       VV+ + +
Sbjct: 67   EDLDNWTALISASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLS 125

Query: 678  RGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATC---WGPGPGGCLQTLLHRAI 734
             GA+ SV       P+  A      DI   L+++G    C   +G  P       L  A 
Sbjct: 126  HGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP-------LVWAA 178

Query: 735  DENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFG 794
             + +      L+  G DV+   Q GAN           T L +A   G  ++V+ +L+  
Sbjct: 179  RKGHLECVKHLLAMGADVD---QEGANS---------MTALIVAVKGGYTQSVKEILKRN 226

Query: 795  ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSA 854
             NVN  D +G T + +A    H  I+Q L+     ++N+ DR G T              
Sbjct: 227  PNVNLTDKDGNTALMIASKEGHTEIVQDLLD-AGTYVNIPDRSGDT-------------- 271

Query: 855  EAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLA 914
                                 L  AV+   +E V  L+  +A+++ R QD    T L+ A
Sbjct: 272  --------------------VLIGAVRGGHVEIVRALLQKYADIDIRGQDNK--TALYWA 309

Query: 915  VQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGN 974
            V+ G+  +VR++L         TK  +T L  A +     +  +LL+ G   +AVD+ G+
Sbjct: 310  VEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD 369

Query: 975  NALHLAVMHGRLNNIRVLLTECTVDAEAF---NLRGQSPLHILGQYGKENAAAIF 1026
              LH+A+  GR   +  LL     D       N  G++P +I   + K     IF
Sbjct: 370  TPLHIAI-RGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 105/429 (24%), Positives = 173/429 (40%), Gaps = 60/429 (13%)

Query: 734  IDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEF 793
            ++E N P    L+    DV            +E    GQTPL +AA  G  E V+ L++ 
Sbjct: 13   VEEENIPALKALLEKCKDV------------DERNECGQTPLMIAAEQGNLEIVKELIKN 60

Query: 794  GANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKS 853
            GAN N +D +  T +  A    H  I++ L+    ++L  RD  G T    A        
Sbjct: 61   GANCNLEDLDNWTALISASKEGHVHIVEELLK-CGVNLEHRDMGGWTALMWACYKGRTDV 119

Query: 854  AEAILKR-------------------------------ESGAAEQVDNK-GRNFLHVAVQ 881
             E +L                                 ++GA     +K G   L  A +
Sbjct: 120  VELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAAR 179

Query: 882  NSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQ 941
               +E V  L+++ A+V+   + A+ +T L +AV+ G    V+ +L     VN   K   
Sbjct: 180  KGHLECVKHLLAMGADVDQ--EGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGN 237

Query: 942  TALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAE 1001
            TAL +A+++    I   LL+ G      D +G+  L  AV  G +  +R LL +      
Sbjct: 238  TALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYA---- 293

Query: 1002 AFNLRGQ-SPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANL 1060
              ++RGQ +   +     K NA  + D+ L+C P   +     DG T L+ A    N  +
Sbjct: 294  DIDIRGQDNKTALYWAVEKGNATMVRDI-LQCNPDTEI--CTKDGETPLIKATKMRNIEV 350

Query: 1061 CRAIVRSGARLGVNNNQGVNIFNYQVATKQLLFRLLDMLSKEPPWCDGSYCYECTARFGV 1120
               ++  GA++   + +G    +  +A +    +L ++L + P   DG   Y    + G 
Sbjct: 351  VELLLDKGAKVSAVDKKGDTPLH--IAIRGRSRKLAELLLRNPK--DGRLLYR-PNKAGE 405

Query: 1121 TTRKHHCRH 1129
            T     C H
Sbjct: 406  TPYNIDCSH 414



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 96/403 (23%), Positives = 169/403 (41%), Gaps = 52/403 (12%)

Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
           V  E     +ALL+   + + ++  G+TPL ++   GN  +  +L++    +  L+D + 
Sbjct: 13  VEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIK-NGANCNLEDLDN 71

Query: 402 STALWLAVQHITVSSDQSVNPFEDVPV--VNGTSFDENSFAA--------------RLIQ 445
            TAL      I+ S +  V+  E++    VN    D   + A               L+ 
Sbjct: 72  WTAL------ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLS 125

Query: 446 RGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLAN 505
            G++       +   ++  AAG G+      L  NGA VN  +K+G TPL  A R G   
Sbjct: 126 HGANPSVTGLYSVYPIIW-AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184

Query: 506 LTAELLQQGANPNLQTEEALP---------LPKEAASLTSLADSVHL-----QTPLHMAI 551
               LL  GA+ + +   ++            +    +     +V+L      T L +A 
Sbjct: 185 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIAS 244

Query: 552 AYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGS 611
              H ++V  +L+                  ++ D    TVL  A+  G   I   LL  
Sbjct: 245 KEGHTEIVQDLLDAGTYV-------------NIPDRSGDTVLIGAVRGGHVEIVRALLQK 291

Query: 612 GAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLV 671
            A I+    D +T L+ A+++ ++     +L+   D  +  T+DGET L  A + +   V
Sbjct: 292 YADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEIC-TKDGETPLIKATKMRNIEV 350

Query: 672 VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD 714
           V+ +  +GA +S  D+KG+ PL +A+      +A  L+R+  D
Sbjct: 351 VELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 82/375 (21%), Positives = 145/375 (38%), Gaps = 30/375 (8%)

Query: 220 YPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHK 279
           YP+  A      D+V L L     Q   K+N +D  G   L  A  +        L++  
Sbjct: 139 YPIIWAAGRGHADIVHLLL-----QNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 280 ADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHS 339
           ADVD    +  + L   ++ G   +   ++K    VN             + + S + H+
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTA----LMIASKEGHT 249

Query: 340 ADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDH 399
                   +I + LL AG   N+ D  G T L  ++  G+  +   LLQ K  D++++  
Sbjct: 250 --------EIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQ-KYADIDIRGQ 300

Query: 400 EGSTALWLAVQHITVSSDQSV---NPFEDV-------PVVNGTSFDENSFAARLIQRGSH 449
           +  TAL+ AV+    +  + +   NP  ++       P++  T          L+ +G+ 
Sbjct: 301 DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK 360

Query: 450 TDAPDTATGNCLLQRAAGAGNEAAALFLAT--NGAHVNHRNKWGETPLHTACRHGLANLT 507
             A D      L     G   + A L L    +G  +   NK GETP +  C H  + LT
Sbjct: 361 VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT 420

Query: 508 AELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKA 567
                +  +P     + L     +++L  +     +Q P+ + +        S +L++  
Sbjct: 421 QIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLE 480

Query: 568 NALHATNNLQIIPDF 582
           + +      QI P F
Sbjct: 481 DEMKTFAGQQIEPLF 495



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 89/411 (21%), Positives = 157/411 (38%), Gaps = 60/411 (14%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           ++E +  G   L +A  +    I   L+ + A+ ++ D   W+ L    + G +     L
Sbjct: 31  VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 90

Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
           +K G  +    +G          +++  K   DV+       E LL  GANP++      
Sbjct: 91  LKCGVNLEHRDMGG-----WTALMWACYKGRTDVV-------ELLLSHGANPSVTGLYSV 138

Query: 369 TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTAL-WLA-------VQHITVS----S 416
            P+  +   G+  +   LLQ     +   D  G+T L W A       V+H+        
Sbjct: 139 YPIIWAAGRGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197

Query: 417 DQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALF 476
            +  N    + V     + ++     +++R  + +  D   GN  L  A+  G+      
Sbjct: 198 QEGANSMTALIVAVKGGYTQS--VKEILKRNPNVNLTD-KDGNTALMIASKEGHTEIVQD 254

Query: 477 LATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTS 536
           L   G +VN  ++ G+T L  A R G   +   LLQ+ A+ +++ ++             
Sbjct: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN------------ 302

Query: 537 LADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLA 596
                  +T L+ A+             +K NA    + LQ  PD  +     +T L  A
Sbjct: 303 -------KTALYWAV-------------EKGNATMVRDILQCNPDTEICTKDGETPLIKA 342

Query: 597 LWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQAD 647
                  +   LL  GA ++     G T LH+AI+ +  K A  LL +  D
Sbjct: 343 TKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
            sapiens]
          Length = 522

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 92/340 (27%), Positives = 151/340 (44%), Gaps = 14/340 (4%)

Query: 730  LHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQC 789
            LH A    +E     L+     V+     GA  E       G   L L+A +G    +Q 
Sbjct: 52   LHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEAR--LCFGMNALLLSAWFGHLRILQI 109

Query: 790  LLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSH-PDIHLNVRDRQGLTPFACAMTF 848
            L+  GA ++ +  +G T +H A    H  ++  ++    D+ L+  D+ G T F  A   
Sbjct: 110  LVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEH 169

Query: 849  KNNKSAEAILKRESGAAEQV-DNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASK 907
                + + ++   SG    V D +G   LH+A     +  +  L+ +  ++    Q+A  
Sbjct: 170  GQLDALDFLVG--SGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEE--QNAEG 225

Query: 908  LTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFA 967
            LT LH A        V+ LL AG+ VN LT+   + LH AA      +  VL+  G    
Sbjct: 226  LTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN 285

Query: 968  AVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFD 1027
             VD  G + LHLAV H     +R+L+   + D  A + R Q+PLH+  ++  ++ A   D
Sbjct: 286  VVDHQGASPLHLAVRHNFPALVRLLINSDS-DVNAVDNRQQTPLHLAAEHAWQDIA---D 341

Query: 1028 LFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRS 1067
            + L  + G  L+  D  G T L +A    + +L   I+++
Sbjct: 342  MLL--IAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 99/394 (25%), Positives = 155/394 (39%), Gaps = 86/394 (21%)

Query: 622 GQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAI-RNQLPL--------VV 672
           G+  LH A      ++   LLEH+A ++        T  +L    N L L        ++
Sbjct: 48  GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107

Query: 673 DAICTRGADMSVPD-----------EKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG 721
             +   GA +               +KG+ P+   +  +LED+A   V            
Sbjct: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDK---------- 157

Query: 722 PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASW 781
                +T  HRA +        FL+ SGCD N             + ++G T LHLAA  
Sbjct: 158 ---LGRTAFHRAAEHGQLDALDFLVGSGCDHNV------------KDKEGNTALHLAAGR 202

Query: 782 GLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTP 841
           G    +Q L++ G ++  Q+AEG T +H A    H   +QLL+                 
Sbjct: 203 GHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL----------------- 245

Query: 842 FACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNS--DIESVLFLISVHANVN 899
                             R       +  K  + LH A  +   D+  VL    +HA   
Sbjct: 246 ------------------RAGSTVNALTQKNLSCLHYAALSGSEDVSRVL----IHAGGC 283

Query: 900 SRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVL 959
           + V D    +PLHLAV+     +VR L+ + + VN +   +QT LHLAA+     I  +L
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML 343

Query: 960 LENGVDFAAVDENGNNALHLAVMHGRLNNIRVLL 993
           L  GVD    D+ G  AL +AV    ++ + +++
Sbjct: 344 LIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 94.4 bits (233), Expect = 6e-19
 Identities = 92/333 (27%), Positives = 138/333 (41%), Gaps = 22/333 (6%)

Query: 547 LHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAA 606
           LH A    H   V ++LE +A A+   + +  + +  L        L L+ W G   I  
Sbjct: 52  LHWAAGAGHEQAVRLLLEHEA-AVDEEDAVGALTEARL--CFGMNALLLSAWFGHLRILQ 108

Query: 607 QLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQD-GETALQLAIR 665
            L+ SGA I+    DG TLLH A Q+       F++E   D+ +      G TA   A  
Sbjct: 109 ILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAE 168

Query: 666 NQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDA--------TC 717
           +     +D +   G D +V D++GN  L LA       +   LV  G D         T 
Sbjct: 169 HGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTA 228

Query: 718 WGPGPGG----CLQTLLH-----RAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEA 768
                GG    C+Q LL       A+ + N     +   SG +  S     A G      
Sbjct: 229 LHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVD 288

Query: 769 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPD 828
             G +PLHLA        V+ L+   ++VNA D   +TP+H+A       I  +L+    
Sbjct: 289 HQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLI-AG 347

Query: 829 IHLNVRDRQGLTPFACAMTFKNNKSAEAILKRE 861
           + LN+RD+QG T  A A+   +    + I+K +
Sbjct: 348 VDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 73/299 (24%), Positives = 120/299 (40%), Gaps = 52/299 (17%)

Query: 348 QIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ-CKQLDLELKDHEGSTALW 406
           +I + L+ +GA  + +   G T LH +   G+  V + +++  + + L+  D  G TA  
Sbjct: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164

Query: 407 LAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAA 466
            A +H            + +  + G+  D N                    GN  L  AA
Sbjct: 165 RAAEH---------GQLDALDFLVGSGCDHNV---------------KDKEGNTALHLAA 200

Query: 467 GAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALP 526
           G G+ A    L   G  +  +N  G T LH+A      +    LL+ G+  N  T++ L 
Sbjct: 201 GRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLS 260

Query: 527 LPKEAASLTS------------LADSVHLQ--TPLHMAIAYNHPDVVSVILEQKANALHA 572
               AA   S             A+ V  Q  +PLH+A+ +N P +V +++   +     
Sbjct: 261 CLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDS----- 315

Query: 573 TNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQ 631
                   D +  D+R QT L LA       IA  LL +G  +N     G+T L +A++
Sbjct: 316 --------DVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVR 366



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 78/328 (23%), Positives = 132/328 (40%), Gaps = 69/328 (21%)

Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPL-HL 329
           I   LV+  A +    K G +LLH   Q+G +    F++++           ++  L H+
Sbjct: 106 ILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMED----------LEDVALDHV 155

Query: 330 VALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQC 389
             L  +  H A    ++  + + L+ +G + N++D +G T LH++   G+  V  +L+  
Sbjct: 156 DKLGRTAFHRAAEHGQLDAL-DFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDI 214

Query: 390 KQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSH 449
             LDLE ++ EG TAL  A                      G+  D       L++ GS 
Sbjct: 215 -GLDLEEQNAEGLTALHSA--------------------AGGSHPD---CVQLLLRAGST 250

Query: 450 TDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAE 509
            +A      +C L  AA +G+E  +  L   G   N  +  G +PLH A RH    L   
Sbjct: 251 VNALTQKNLSC-LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRL 309

Query: 510 LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA 569
           L+   ++ N                   A     QTPLH+A  +   D+  ++L      
Sbjct: 310 LINSDSDVN-------------------AVDNRQQTPLHLAAEHAWQDIADMLLIAGV-- 348

Query: 570 LHATNNLQIIPDFSLKDSRDQTVLGLAL 597
                      D +L+D + +T L +A+
Sbjct: 349 -----------DLNLRDKQGKTALAVAV 365



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 91/396 (22%), Positives = 145/396 (36%), Gaps = 85/396 (21%)

Query: 338 HSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELK 397
           H A   + + ++ E L+    N   ++  GR  LH +  AG+E     LL+         
Sbjct: 20  HEAARQNNVGRMQE-LIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLE--------- 69

Query: 398 DHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTS-------FDENSFAARLIQRGS-- 448
            HE +           V  + +V    +  +  G +       F        L+  G+  
Sbjct: 70  -HEAA-----------VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKI 117

Query: 449 HTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHV--NHRNKWGETPLHTACRHGLANL 506
           H ++ D  T   LL  AA  G+     F+  +   V  +H +K G T  H A  HG  + 
Sbjct: 118 HCESKDGLT---LLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDA 174

Query: 507 TAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQK 566
              L+  G + N++ +E                     T LH+A    H  V        
Sbjct: 175 LDFLVGSGCDHNVKDKEG-------------------NTALHLAAGRGHMAV-------- 207

Query: 567 ANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQ--------LLGSGAAINDT 618
                    LQ + D  L D  +Q   GL   T +H+ A          LL +G+ +N  
Sbjct: 208 ---------LQRLVDIGL-DLEEQNAEGL---TALHSAAGGSHPDCVQLLLRAGSTVNAL 254

Query: 619 MSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTR 678
                + LH A        +  L+      NV   Q G + L LA+R+  P +V  +   
Sbjct: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQ-GASPLHLAVRHNFPALVRLLINS 313

Query: 679 GADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD 714
            +D++  D +   PL LA  +  +DIA  L+  G D
Sbjct: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVD 349



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 78/320 (24%), Positives = 124/320 (38%), Gaps = 57/320 (17%)

Query: 771  GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGR----------TPIHVAISSQHGVII 820
            G+  LH AA  G E+ V+ LLE  A V+ +DA G             + ++    H  I+
Sbjct: 48   GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107

Query: 821  QLLV-SHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKR--ESGAAEQVDNKGRNFLH 877
            Q+LV S   IH   +D  GLT   CA   K +    A +    E  A + VD  GR   H
Sbjct: 108  QILVNSGAKIHCESKD--GLTLLHCAAQ-KGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164

Query: 878  VAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELT 937
             A ++  ++++ FL+                                    +G   N   
Sbjct: 165  RAAEHGQLDALDFLVG-----------------------------------SGCDHNVKD 189

Query: 938  KHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECT 997
            K   TALHLAA +    +   L++ G+D    +  G  ALH A      + +++LL   +
Sbjct: 190  KEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGS 249

Query: 998  VDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGN 1057
                A   +  S LH     G E+ + +         G   +  D  G++ L LA     
Sbjct: 250  T-VNALTQKNLSCLHYAALSGSEDVSRVL-----IHAGGCANVVDHQGASPLHLAVRHNF 303

Query: 1058 ANLCRAIVRSGARLGVNNNQ 1077
              L R ++ S + +   +N+
Sbjct: 304  PALVRLLINSDSDVNAVDNR 323



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 13/162 (8%)

Query: 250 NEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLI 309
           N  D  G+ AL LA  R   ++   LV    D++  +  G + LH             L+
Sbjct: 186 NVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 245

Query: 310 KNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRT 369
           + G+ VNA T     + LH  AL  S+            ++  L+ AG   N+ D +G +
Sbjct: 246 RAGSTVNALT-QKNLSCLHYAALSGSE-----------DVSRVLIHAGGCANVVDHQGAS 293

Query: 370 PLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH 411
           PLH+++   N     +LL     D+   D+   T L LA +H
Sbjct: 294 PLHLAV-RHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEH 334



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 53/223 (23%), Positives = 101/223 (45%), Gaps = 16/223 (7%)

Query: 872  GRNFLHVAVQNSDIESVLFLISVHANVN--------SRVQDASKLTPLHLAVQAGSEIIV 923
            GR  LH A      ++V  L+   A V+        +  +    +  L L+   G   I+
Sbjct: 48   GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107

Query: 924  RNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAA--VDENGNNALHLAV 981
            + L+ +GAK++  +K   T LH AAQ+    + + ++E+  D A   VD+ G  A H A 
Sbjct: 108  QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167

Query: 982  MHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKP 1041
             HG+L+ +  L+     D    +  G + LH+    G     A+    ++   G  L++ 
Sbjct: 168  EHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGH---MAVLQRLVDI--GLDLEEQ 221

Query: 1042 DADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVNIFNY 1084
            +A+G T L  A    + +  + ++R+G+ +     + ++  +Y
Sbjct: 222  NAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHY 264



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 35/131 (26%), Positives = 63/131 (48%), Gaps = 12/131 (9%)

Query: 269 ESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLH 328
           E ++  L+      ++VD  G S LH  ++         LI + + VNA     Q+TPLH
Sbjct: 271 EDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVD-NRQQTPLH 329

Query: 329 LVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
           L A ++ +            IA+ LL AG + N++D +G+T L V++ + +  +   +++
Sbjct: 330 LAAEHAWQ-----------DIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378

Query: 389 CKQLDLELKDH 399
             +     KDH
Sbjct: 379 ADRFYRWEKDH 389



 Score = 31.2 bits (69), Expect = 6.0
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 5/94 (5%)

Query: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKA 280
           PLH A++     +V L LI  DS +    N  D+     L LA     + IA  L+    
Sbjct: 294 PLHLAVRHNFPALVRL-LINSDSDV----NAVDNRQQTPLHLAAEHAWQDIADMLLIAGV 348

Query: 281 DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAF 314
           D+++ DK G + L   ++   +     +IK   F
Sbjct: 349 DLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRF 382


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 147/555 (26%), Positives = 206/555 (37%), Gaps = 89/555 (16%)

Query: 455 TATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQG 514
           T++ +C L  AA A     A   A  G   N         L  AC  G  N   +LL +G
Sbjct: 205 TSSVSCALDEAAAALTRMRAESTANAGQSDNRS-------LAEACSEGDVNAVRKLLIEG 257

Query: 515 ANPNLQTEEALPLPKEAAS-----LTSLADSVHLQ----------TPLHMAIAYNHPDVV 559
            + N  TEE   L   A S     L  +  ++H            TPL  A    H  +V
Sbjct: 258 RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIV 317

Query: 560 SVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTM 619
            ++L  KA             D + + S   T L  A   G   +   LL SGA+I D  
Sbjct: 318 KLLLAHKA-------------DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364

Query: 620 SDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRG 679
            +G T L  A      + A  LLE+ A IN    +  E+AL LA       +V  +   G
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424

Query: 680 ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNE 739
           AD     ++ +  L  A  +   ++A  L+  G         P    ++ L  A    + 
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLAACGGHV 480

Query: 740 PTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNA 799
             A  LI  G  +            EE   +G TPL  AA  G EE V  LL  GAN+NA
Sbjct: 481 ELAALLIERGASL------------EEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528

Query: 800 QDAEGR-------------------------------TPIHVAISSQHGVIIQ-LLVSHP 827
           Q  E +                               TP+  A    H  +++ LL +  
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGA 588

Query: 828 DIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIE 886
           ++H           +AC    +N  +  A +  ++GA  E     GR  L  A +   + 
Sbjct: 589 NVHATTATGDTALTYAC----ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644

Query: 887 SVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHL 946
           +V FLIS  ANVN R    +  T L LA   G   +V  LL  GA      K   T L  
Sbjct: 645 TVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703

Query: 947 AAQQDLPTICSVLLE 961
           AA+    ++   LL+
Sbjct: 704 AAKGGHTSVVCYLLD 718



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 104/407 (25%), Positives = 163/407 (40%), Gaps = 23/407 (5%)

Query: 590 QTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQ-TLLHMAIQRQDSKSALFLLEHQADI 648
           +++L LA   G + +A  LL   A + D    G  T L  A      K    LL H+AD+
Sbjct: 268 ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327

Query: 649 NVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTL 708
           N +++  G TAL  A       VV  +   GA +   +E G+ PL  A +    ++A  L
Sbjct: 328 N-AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386

Query: 709 VRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEA 768
           + +G              ++ L  A  + +     FL+ +G D             E + 
Sbjct: 387 LENGAGINTHS---NEFKESALTLACYKGHLEMVRFLLEAGADQ------------EHKT 431

Query: 769 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPD 828
            +  T L  A   G  E  + LL+ GA VN       +P+ +A    H  +  LL+    
Sbjct: 432 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491

Query: 829 IHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESV 888
               V D +G TP   A    + +    +L + +    Q +      L +A     +E  
Sbjct: 492 SLEEVND-EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVA 550

Query: 889 LFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAA 948
            FLI   A++     +    TPL  A Q G   +V+ LL AGA V+  T    TAL  A 
Sbjct: 551 DFLIKAGADI-----ELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605

Query: 949 QQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTE 995
           +     +  VLL+ G D     E G   L  A   G +  ++ L+++
Sbjct: 606 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 124/458 (27%), Positives = 182/458 (39%), Gaps = 53/458 (11%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADV-DMVDKSGWSLLHKGIQRGDLFAATF 307
           +NE    G+  L LA S     +A  L++  A+V D   K   + L      G +     
Sbjct: 260 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKL 319

Query: 308 LIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
           L+ + A VNA     Q +  +    Y+      DV+       + LL++GA+    +  G
Sbjct: 320 LLAHKADVNA-----QSSTGNTALTYACAGGYVDVV-------KVLLESGASIEDHNENG 367

Query: 368 RTPLHVSIMAGNEYVFSQLLQ-----------CKQLDLELKDHEGSTALWLAVQHITVSS 416
            TPL  +  AG+  V   LL+            K+  L L  ++G   +   +  +   +
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL--LEAGA 425

Query: 417 DQSVNPFEDVPVVNGTSFDENSFAARLI-QRGSHTDAPDTATGNCLLQRAAGAGNEAAAL 475
           DQ     E    +     D +   ARL+   G+  + P  +  + L   A G   E AAL
Sbjct: 426 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 485

Query: 476 FLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEE----ALPLP--- 528
            L   GA +   N  G TPL  A R G   + A LL QGAN N QTEE    AL L    
Sbjct: 486 -LIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544

Query: 529 ---KEAASLTSLADSVHL--QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 583
              + A  L      + L   TPL  A    H ++V  +L   AN +HAT          
Sbjct: 545 GFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGAN-VHATT--------- 594

Query: 584 LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 643
              +   T L  A   G   +A  LL +GA +      G+T L  A +     +  FL+ 
Sbjct: 595 ---ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651

Query: 644 HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGAD 681
             A++N +   +  T L LA       VV+ +   GAD
Sbjct: 652 KGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGAD 689



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 93/331 (28%), Positives = 152/331 (45%), Gaps = 17/331 (5%)

Query: 755  PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS 814
            P  P  + + + E+    T L LA + G EE VQ LLE GA++  +D +G TP+ +A ++
Sbjct: 1068 PIYPAIDIDAQTESNH-DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATA 1126

Query: 815  QH-GVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN-KG 872
             H GV+  LL +  DI     +R   TP + A +    +  E +L R  GA ++  N   
Sbjct: 1127 GHVGVVEILLDNGADIEAQ-SERTKDTPLSLACSGGRQEVVELLLAR--GANKEHRNVSD 1183

Query: 873  RNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAK 932
               L +A     +  +  L++  A +NSR      ++PL LA   G    V+ LL  G+ 
Sbjct: 1184 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 1243

Query: 933  VN-ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRV 991
            +N ++  +R TAL LA  Q    + S+LL+   +     + G   L  A   G     RV
Sbjct: 1244 INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1303

Query: 992  LLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECM--PGYPLDKPDADGSTV 1048
            LL +   V+A        + L I    G          F E +   G  +D  +  G+T 
Sbjct: 1304 LLDKGADVNAPPVPSSRDTALTIAADKGHYK-------FCELLIGRGAHIDVRNKKGNTP 1356

Query: 1049 LLLAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
            L LA   G+ ++ + +V++GA +   +N+ +
Sbjct: 1357 LWLAANGGHLDVVQLLVQAGADVDAADNRKI 1387



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 98/406 (24%), Positives = 153/406 (37%), Gaps = 59/406 (14%)

Query: 313  AFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQ-DSKGRTPL 371
            A V+        TP H +A   S+  +      ++  A   +    + + Q +S   T L
Sbjct: 1028 AAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTAL 1087

Query: 372  HVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITVSSDQSVNPFEDVPVV 429
             ++   G+E +   LL+ +   +E +D +G T L LA    H+ V               
Sbjct: 1088 TLACAGGHEELVQTLLE-RGASIEHRDKKGFTPLILAATAGHVGV--------------- 1131

Query: 430  NGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNK 489
                         L+  G+  +A    T +  L  A   G +     L   GA+  HRN 
Sbjct: 1132 ----------VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181

Query: 490  WGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHM 549
               TPL  A   G  N+   LL  GA  N +T   L +                 +PL +
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI-----------------SPLML 1224

Query: 550  AIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLL 609
            A    H   V ++L+  ++      N QI       ++   T L LA + G   + + LL
Sbjct: 1225 AAMNGHTAAVKLLLDMGSDI-----NAQI-------ETNRNTALTLACFQGRTEVVSLLL 1272

Query: 610  GSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDG-ETALQLAIRNQL 668
               A +      G T L  A     ++    LL+  AD+N        +TAL +A     
Sbjct: 1273 DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGH 1332

Query: 669  PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD 714
                + +  RGA + V ++KGN PLWLA      D+   LV+ G D
Sbjct: 1333 YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 93/366 (25%), Positives = 141/366 (38%), Gaps = 24/366 (6%)

Query: 635  SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
            S SA+  +    DI+     + +TAL LA       +V  +  RGA +   D+KG  PL 
Sbjct: 1062 SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 1121

Query: 695  LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 754
            LA       +   L+ +G D                  A  E  + T   L  SG     
Sbjct: 1122 LAATAGHVGVVEILLDNGADI----------------EAQSERTKDTPLSLACSGGRQEV 1165

Query: 755  PRQPGANGEGEEEAR-DGQTPLHLAASWGLEETVQCLLEFGANVNAQDAE--GRTPIHVA 811
                 A G  +E       TPL LAAS G    ++ LL  GA +N++     G +P+ +A
Sbjct: 1166 VELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLA 1225

Query: 812  ISSQHGVIIQLLVSH-PDIHLNVR-DRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVD 869
              + H   ++LL+    DI+  +  +R      AC   F+      ++L       E   
Sbjct: 1226 AMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC---FQGRTEVVSLLLDRKANVEHRA 1282

Query: 870  NKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLA 929
              G   L  A      E    L+   A+VN+    +S+ T L +A   G       L+  
Sbjct: 1283 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1342

Query: 930  GAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNI 989
            GA ++   K   T L LAA      +  +L++ G D  A D      L  A   G +  +
Sbjct: 1343 GAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVV 1402

Query: 990  RVLLTE 995
            R L+ E
Sbjct: 1403 RYLVKE 1408



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 89/351 (25%), Positives = 137/351 (39%), Gaps = 60/351 (17%)

Query: 251  EADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIK 310
            + + N D AL LA +   E +  TL+   A ++  DK G++ L      G +     L+ 
Sbjct: 1078 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137

Query: 311  NGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTP 370
            NGA + A +   ++TPL L                  ++ E LL  GAN   ++    TP
Sbjct: 1138 NGADIEAQSERTKDTPLSLAC-----------SGGRQEVVELLLARGANKEHRNVSDYTP 1186

Query: 371  LHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVN 430
            L ++   G   +   LL       E+    GS    L +  + +++            +N
Sbjct: 1187 LSLAASGGYVNIIKILLNA---GAEINSRTGSK---LGISPLMLAA------------MN 1228

Query: 431  GTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKW 490
            G      +    L+  GS  +A      N  L  A   G       L    A+V HR K 
Sbjct: 1229 G----HTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKT 1284

Query: 491  GETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEA-ASLTSLADSVHLQ----- 544
            G TPL  A   G A +   LL +GA+ N     A P+P     +LT  AD  H +     
Sbjct: 1285 GLTPLMEAASGGYAEVGRVLLDKGADVN-----APPVPSSRDTALTIAADKGHYKFCELL 1339

Query: 545  ---------------TPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIP 580
                           TPL +A    H DVV ++++  A+ + A +N +I P
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD-VDAADNRKITP 1389



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 102/401 (25%), Positives = 160/401 (39%), Gaps = 27/401 (6%)

Query: 586  DSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQ 645
            +S   T L LA   G   +   LL  GA+I      G T L +A           LL++ 
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139

Query: 646  ADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIA 705
            ADI     +  +T L LA       VV+ +  RGA+    +     PL LA +    +I 
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199

Query: 706  STLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGE 765
              L+  G +         G    +L  A    +      L+  G D+N+  +   N    
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLML--AAMNGHTAAVKLLLDMGSDINAQIETNRN---- 1253

Query: 766  EEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVS 825
                   T L LA   G  E V  LL+  ANV  +   G TP+  A S  +  + ++L+ 
Sbjct: 1254 -------TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1306

Query: 826  H-PDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN-KGRNFLHVAVQNS 883
               D++         T    A    + K  E ++ R  GA   V N KG   L +A    
Sbjct: 1307 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR--GAHIDVRNKKGNTPLWLAANGG 1364

Query: 884  DIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTA 943
             ++ V  L+   A+V++   D  K+TPL  A + G   +VR L+    +VN+     +  
Sbjct: 1365 HLDVVQLLVQAGADVDA--ADNRKITPLMAAFRKGHVKVVRYLV---KEVNQFPSDSECM 1419

Query: 944  LHLAAQQDLPTI--CSVLLENGV---DFAAVDENGNNALHL 979
             ++A   D   +  C + +E+ V   D  A + N N ++ L
Sbjct: 1420 RYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILL 1460



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 97/432 (22%), Positives = 162/432 (37%), Gaps = 75/432 (17%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           +N     G+ AL  A +     +   L+   A ++  +++G + L +    G +  A  L
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386

Query: 309 IKNGAFVN---------AATLGAQETPLHLVALY----SSKKHSADVMSEM--------- 346
           ++NGA +N         A TL   +  L +V       + ++H  D M            
Sbjct: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446

Query: 347 AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALW 406
            ++A  LL +GA  NM      +PL ++   G+  + + L++ +   LE  + EG T L 
Sbjct: 447 VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE-RGASLEEVNDEGYTPLM 505

Query: 407 LAVQH-----ITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATG--- 458
            A +      + +   Q  N       +N  + +    A  L   G   +  D       
Sbjct: 506 EAAREGHEEMVALLLGQGAN-------INAQTEETQETALTLACCGGFLEVADFLIKAGA 558

Query: 459 ------NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQ 512
                 +  L  AA  G+     +L   GA+V+     G+T L  AC +G  ++   LLQ
Sbjct: 559 DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618

Query: 513 QGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHA 572
            GA+   ++E                     +TPL  A    H   V  ++ + AN    
Sbjct: 619 AGADLEHESEGG-------------------RTPLMKAARAGHVCTVQFLISKGANVNRT 659

Query: 573 TNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQR 632
           T N             D TVL LA   G   +   LL  GA     + DG T+L  A + 
Sbjct: 660 TAN------------NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707

Query: 633 QDSKSALFLLEH 644
             +    +LL++
Sbjct: 708 GHTSVVCYLLDY 719



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 68/265 (25%), Positives = 101/265 (38%), Gaps = 43/265 (16%)

Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
           +A  L+   A ++ V+  G++ L +  + G       L+  GA +NA T   QET L L 
Sbjct: 482 LAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLA 541

Query: 331 ALYSSK-------KHSADV-------MSEMAQ-----IAEALLQAGANPNMQDSKGRTPL 371
                        K  AD+       + E AQ     + + LL AGAN +   + G T L
Sbjct: 542 CCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTAL 601

Query: 372 HVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNG 431
             +   G+  V   LLQ    DLE +   G T L  A +   V + Q             
Sbjct: 602 TYACENGHTDVADVLLQAGA-DLEHESEGGRTPLMKAARAGHVCTVQF------------ 648

Query: 432 TSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWG 491
                      LI +G++ +       + +L  A   G+ A    L  +GA   HR K G
Sbjct: 649 -----------LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG 697

Query: 492 ETPLHTACRHGLANLTAELLQQGAN 516
            T L  A + G  ++   LL    N
Sbjct: 698 STMLIEAAKGGHTSVVCYLLDYPNN 722


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 122/494 (24%), Positives = 196/494 (39%), Gaps = 77/494 (15%)

Query: 544 QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHT 603
           +TPL   +  +  D    +L+  A             D +  D   +T L LA   G + 
Sbjct: 49  RTPLMYCVLADRLDCADALLKAGA-------------DVNKTDHSQRTALHLAAQKGNYR 95

Query: 604 IAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDG--ETALQ 661
               LL   A       +  T LH+  + +  K    LL+  A   V  TQD   +TAL 
Sbjct: 96  FMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVD-TQDKNKQTALH 154

Query: 662 LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATC---- 717
            +     P  V  +    +++ +PD +G  PL  A AN+ +  A   VR   DA      
Sbjct: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA-ANHKDPSAVHTVRCILDAAPTESL 213

Query: 718 --WGPGPGGCLQTLLHRAIDENNEPTACFLIR-SGCDVNSPRQPGANGEGEEEARDGQTP 774
             W    G   +T LH A+ + N      L     C++ S                 +TP
Sbjct: 214 LNWQDYEG---RTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF------------RTP 258

Query: 775 LHLAASWGLEETVQCLLEFG-ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNV 833
           LH AA  G  + V  LLE   +     D++G TP+H A  S     +++ + HP +  + 
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK-DD 317

Query: 834 RDRQGLTPFACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLI 892
            D +G T F  A    ++     +L  +S       D  G   LH A  +  + +V  L+
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 893 SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
             +A V++   D  K TPL  A + G + +++ L+  GA+V+ + +   + LH AA    
Sbjct: 378 ENNAQVDAT--DVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435

Query: 953 PTICSVLLENGV-----DFAA----------------------------VDENGNNALHL 979
             +C +L+EN +     D+A                              D+ G  ALH 
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495

Query: 980 AVMHGRLNNIRVLL 993
           +  +G L+ I++LL
Sbjct: 496 SCNNGYLDAIKLLL 509



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 110/490 (22%), Positives = 193/490 (39%), Gaps = 91/490 (18%)

Query: 578  IIPDFSLKDSRDQ---TVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQD 634
            I+ + +LKD  DQ   T L   +       A  LL +GA +N T    +T LH+A Q+ +
Sbjct: 34   IVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGN 93

Query: 635  SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
             +    LL  +A+  + +  +  T L L  R++ P  +  +    A   V  +  N    
Sbjct: 94   YRFMKLLLTRRANW-MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNK--- 149

Query: 695  LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 754
                                            QT LH +   NN      LI+   ++  
Sbjct: 150  --------------------------------QTALHWSAYYNNPEHVKLLIKHDSNIGI 177

Query: 755  PRQPGANGEGEEEARDGQTPLHLAASW---GLEETVQCLLEFGAN---VNAQDAEGRTPI 808
            P              +G+ PLH AA+        TV+C+L+       +N QD EGRTP+
Sbjct: 178  PDV------------EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPL 225

Query: 809  HVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV 868
            H A++  +  ++ +L S+   ++   D    TP   A    + +    +L+R        
Sbjct: 226  HFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS 285

Query: 869  DNKGRNFLHVAVQNSDIESV-LFL--------------------------------ISVH 895
            D++G   LH A Q++  E+V +FL                                +S+ 
Sbjct: 286  DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345

Query: 896  ANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTI 955
            ++++  + D    T LH A  +G    V+ LL   A+V+     + T L  A +     +
Sbjct: 346  SDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405

Query: 956  CSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILG 1015
               L++ G     VD++G++ LH A + G  +  ++L+ E  ++    +  G++PL    
Sbjct: 406  IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI-ENKINPNVQDYAGRTPLQCAA 464

Query: 1016 QYGKENAAAI 1025
              G  N  A+
Sbjct: 465  YGGYINCMAV 474



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 125/540 (23%), Positives = 204/540 (37%), Gaps = 69/540 (12%)

Query: 423 FEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGA 482
           F   P++     D    A  L++ G+  +  D +    L   AA  GN      L T  A
Sbjct: 47  FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTAL-HLAAQKGNYRFMKLLLTRRA 105

Query: 483 HVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVH 542
           +   ++    TPLH   RH      A LL+  A   + T++                  +
Sbjct: 106 NWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK-----------------N 148

Query: 543 LQTPLHMAIAYNHPDVVSVILEQKANA----------LHATNN-------------LQII 579
            QT LH +  YN+P+ V ++++  +N           LH   N             L   
Sbjct: 149 KQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAA 208

Query: 580 PDFSL---KDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG--QTLLHMAIQRQD 634
           P  SL   +D   +T L  A+  G  T+   +L S  + N T  D   +T LH A     
Sbjct: 209 PTESLLNWQDYEGRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGH 267

Query: 635 SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
           ++    LLE      +     G T L  A ++     V       +     D +G     
Sbjct: 268 AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327

Query: 695 LALANNLEDIASTLVRHGCDATC-WGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVN 753
            A     +D+  T++    D         GG   T LH A    +  T   L+ +   V 
Sbjct: 328 WAAGKGSDDVLRTMLSLKSDIDINMADKYGG---TALHAAALSGHVSTVKLLLENNAQV- 383

Query: 754 SPRQPGANGEGEEEARD--GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVA 811
                        +A D    TPL  A   G ++ +Q L++ GA V+  D +G + +H A
Sbjct: 384 -------------DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430

Query: 812 ISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNK 871
               +  + Q+L+ +  I+ NV+D  G TP  CA  +    +  A+L   +      D +
Sbjct: 431 ALGGNADVCQILIENK-INPNVQDYAGRTPLQCA-AYGGYINCMAVLMENNADPNIQDKE 488

Query: 872 GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGA 931
           GR  LH +  N  ++++  L+   A  N    +  + TPL  A+      +++ +L  GA
Sbjct: 489 GRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 121/502 (24%), Positives = 197/502 (39%), Gaps = 67/502 (13%)

Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
           V+++    A+ALL+AGA+ N  D   RT LH++   GN Y F +LL  ++ +   KD E 
Sbjct: 56  VLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGN-YRFMKLLLTRRANWMQKDLEE 114

Query: 402 STALWLAVQH-----------ITVSSDQSVNPFEDVPVVNGTSFDENSFAARL-IQRGSH 449
            T L L  +H                +           ++ +++  N    +L I+  S+
Sbjct: 115 MTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSN 174

Query: 450 TDAPDTATGNCLLQRAAGAGNEAAA------LFLATNGAHVNHRNKWGETPLHTACRHGL 503
              PD   G   L  AA   + +A       L  A   + +N ++  G TPLH A   G 
Sbjct: 175 IGIPDVE-GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGN 233

Query: 504 ANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVIL 563
             +   L                   E+ ++TS  +    +TPLH A    H  +V ++L
Sbjct: 234 VTVVDVLTSY----------------ESCNITSYDNL--FRTPLHWAALLGHAQIVHLLL 275

Query: 564 EQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQ 623
           E+        N    IP     DS+  T L  A  +         L   +  +D+  +G+
Sbjct: 276 ER--------NKSGTIPS----DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGR 323

Query: 624 TLLHMAIQRQDSKSALFLLEHQADINVSRTQD-GETALQLAIRNQLPLVVDAICTRGADM 682
           T    A  +        +L  ++DI+++     G TAL  A  +     V  +    A +
Sbjct: 324 TSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQV 383

Query: 683 SVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTA 742
              D   + PL+ A     +D+  TL++ G               +LLH A    N    
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG----HSLLHWAALGGNADVC 439

Query: 743 CFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDA 802
             LI +  + N             +   G+TPL  AA  G    +  L+E  A+ N QD 
Sbjct: 440 QILIENKINPNV------------QDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487

Query: 803 EGRTPIHVAISSQHGVIIQLLV 824
           EGRT +H + ++ +   I+LL+
Sbjct: 488 EGRTALHWSCNNGYLDAIKLLL 509



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 87/385 (22%), Positives = 147/385 (38%), Gaps = 41/385 (10%)

Query: 221 PLHKAIKVEREDVVFLYLIEMDSQ-LPGKLNEADHNGDLALDLALSRRLESIATTLVSHK 279
           PLH A   +    V      +D+      LN  D+ G   L  A++    ++   L S++
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244

Query: 280 A-DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKH 338
           + ++   D    + LH     G       L++        +     TPLH  A       
Sbjct: 245 SCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAA------- 297

Query: 339 SADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQ-LDLELK 397
                S  A+  +  L+  +  +  D +GRT    +   G++ V   +L  K  +D+ + 
Sbjct: 298 ----QSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353

Query: 398 DHEGSTALWLAVQHITVSSDQ----------SVNPFEDVPVVNGTSFDENSFAARLIQRG 447
           D  G TAL  A     VS+ +          + +  +  P+              LI+ G
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413

Query: 448 SHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLT 507
           +  D  D   G+ LL  AA  GN      L  N  + N ++  G TPL  A   G  N  
Sbjct: 414 ARVDLVDQ-DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCM 472

Query: 508 AELLQQGANPNLQTEE---------------ALPLPKE-AASLTSLADSVHLQTPLHMAI 551
           A L++  A+PN+Q +E               A+ L  + AA    + ++    TPL  A+
Sbjct: 473 AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532

Query: 552 AYNHPDVVSVILEQKANALHATNNL 576
                +V+  +LE  A ++ A  ++
Sbjct: 533 LGERHEVIQFMLEHGALSIAAIQDI 557


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 122/494 (24%), Positives = 196/494 (39%), Gaps = 77/494 (15%)

Query: 544 QTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHT 603
           +TPL   +  +  D    +L+  A             D +  D   +T L LA   G + 
Sbjct: 49  RTPLMYCVLADRLDCADALLKAGA-------------DVNKTDHSQRTALHLAAQKGNYR 95

Query: 604 IAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDG--ETALQ 661
               LL   A       +  T LH+  + +  K    LL+  A   V  TQD   +TAL 
Sbjct: 96  FMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVD-TQDKNKQTALH 154

Query: 662 LAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATC---- 717
            +     P  V  +    +++ +PD +G  PL  A AN+ +  A   VR   DA      
Sbjct: 155 WSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA-ANHKDPSAVHTVRCILDAAPTESL 213

Query: 718 --WGPGPGGCLQTLLHRAIDENNEPTACFLIR-SGCDVNSPRQPGANGEGEEEARDGQTP 774
             W    G   +T LH A+ + N      L     C++ S                 +TP
Sbjct: 214 LNWQDYEG---RTPLHFAVADGNVTVVDVLTSYESCNITSYDNLF------------RTP 258

Query: 775 LHLAASWGLEETVQCLLEFG-ANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNV 833
           LH AA  G  + V  LLE   +     D++G TP+H A  S     +++ + HP +  + 
Sbjct: 259 LHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVK-DD 317

Query: 834 RDRQGLTPFACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLI 892
            D +G T F  A    ++     +L  +S       D  G   LH A  +  + +V  L+
Sbjct: 318 SDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL 377

Query: 893 SVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDL 952
             +A V++   D  K TPL  A + G + +++ L+  GA+V+ + +   + LH AA    
Sbjct: 378 ENNAQVDAT--DVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGN 435

Query: 953 PTICSVLLENGV-----DFAA----------------------------VDENGNNALHL 979
             +C +L+EN +     D+A                              D+ G  ALH 
Sbjct: 436 ADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHW 495

Query: 980 AVMHGRLNNIRVLL 993
           +  +G L+ I++LL
Sbjct: 496 SCNNGYLDAIKLLL 509



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 110/490 (22%), Positives = 193/490 (39%), Gaps = 91/490 (18%)

Query: 578  IIPDFSLKDSRDQ---TVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQD 634
            I+ + +LKD  DQ   T L   +       A  LL +GA +N T    +T LH+A Q+ +
Sbjct: 34   IVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGN 93

Query: 635  SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
             +    LL  +A+  + +  +  T L L  R++ P  +  +    A   V  +  N    
Sbjct: 94   YRFMKLLLTRRANW-MQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNK--- 149

Query: 695  LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 754
                                            QT LH +   NN      LI+   ++  
Sbjct: 150  --------------------------------QTALHWSAYYNNPEHVKLLIKHDSNIGI 177

Query: 755  PRQPGANGEGEEEARDGQTPLHLAASW---GLEETVQCLLEFGAN---VNAQDAEGRTPI 808
            P              +G+ PLH AA+        TV+C+L+       +N QD EGRTP+
Sbjct: 178  PDV------------EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPL 225

Query: 809  HVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV 868
            H A++  +  ++ +L S+   ++   D    TP   A    + +    +L+R        
Sbjct: 226  HFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS 285

Query: 869  DNKGRNFLHVAVQNSDIESV-LFL--------------------------------ISVH 895
            D++G   LH A Q++  E+V +FL                                +S+ 
Sbjct: 286  DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345

Query: 896  ANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTI 955
            ++++  + D    T LH A  +G    V+ LL   A+V+     + T L  A +     +
Sbjct: 346  SDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405

Query: 956  CSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILG 1015
               L++ G     VD++G++ LH A + G  +  ++L+ E  ++    +  G++PL    
Sbjct: 406  IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI-ENKINPNVQDYAGRTPLQCAA 464

Query: 1016 QYGKENAAAI 1025
              G  N  A+
Sbjct: 465  YGGYINCMAV 474



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 125/540 (23%), Positives = 204/540 (37%), Gaps = 69/540 (12%)

Query: 423 FEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGA 482
           F   P++     D    A  L++ G+  +  D +    L   AA  GN      L T  A
Sbjct: 47  FGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTAL-HLAAQKGNYRFMKLLLTRRA 105

Query: 483 HVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVH 542
           +   ++    TPLH   RH      A LL+  A   + T++                  +
Sbjct: 106 NWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDK-----------------N 148

Query: 543 LQTPLHMAIAYNHPDVVSVILEQKANA----------LHATNN-------------LQII 579
            QT LH +  YN+P+ V ++++  +N           LH   N             L   
Sbjct: 149 KQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAA 208

Query: 580 PDFSL---KDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG--QTLLHMAIQRQD 634
           P  SL   +D   +T L  A+  G  T+   +L S  + N T  D   +T LH A     
Sbjct: 209 PTESLLNWQDYEGRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGH 267

Query: 635 SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
           ++    LLE      +     G T L  A ++     V       +     D +G     
Sbjct: 268 AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFM 327

Query: 695 LALANNLEDIASTLVRHGCDATC-WGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVN 753
            A     +D+  T++    D         GG   T LH A    +  T   L+ +   V 
Sbjct: 328 WAAGKGSDDVLRTMLSLKSDIDINMADKYGG---TALHAAALSGHVSTVKLLLENNAQV- 383

Query: 754 SPRQPGANGEGEEEARD--GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVA 811
                        +A D    TPL  A   G ++ +Q L++ GA V+  D +G + +H A
Sbjct: 384 -------------DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430

Query: 812 ISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNK 871
               +  + Q+L+ +  I+ NV+D  G TP  CA  +    +  A+L   +      D +
Sbjct: 431 ALGGNADVCQILIENK-INPNVQDYAGRTPLQCA-AYGGYINCMAVLMENNADPNIQDKE 488

Query: 872 GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGA 931
           GR  LH +  N  ++++  L+   A  N    +  + TPL  A+      +++ +L  GA
Sbjct: 489 GRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 121/502 (24%), Positives = 197/502 (39%), Gaps = 67/502 (13%)

Query: 342 VMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEG 401
           V+++    A+ALL+AGA+ N  D   RT LH++   GN Y F +LL  ++ +   KD E 
Sbjct: 56  VLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGN-YRFMKLLLTRRANWMQKDLEE 114

Query: 402 STALWLAVQH-----------ITVSSDQSVNPFEDVPVVNGTSFDENSFAARL-IQRGSH 449
            T L L  +H                +           ++ +++  N    +L I+  S+
Sbjct: 115 MTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSN 174

Query: 450 TDAPDTATGNCLLQRAAGAGNEAAA------LFLATNGAHVNHRNKWGETPLHTACRHGL 503
              PD   G   L  AA   + +A       L  A   + +N ++  G TPLH A   G 
Sbjct: 175 IGIPDVE-GKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGN 233

Query: 504 ANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVIL 563
             +   L                   E+ ++TS  +    +TPLH A    H  +V ++L
Sbjct: 234 VTVVDVLTSY----------------ESCNITSYDNL--FRTPLHWAALLGHAQIVHLLL 275

Query: 564 EQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQ 623
           E+        N    IP     DS+  T L  A  +         L   +  +D+  +G+
Sbjct: 276 ER--------NKSGTIPS----DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGR 323

Query: 624 TLLHMAIQRQDSKSALFLLEHQADINVSRTQD-GETALQLAIRNQLPLVVDAICTRGADM 682
           T    A  +        +L  ++DI+++     G TAL  A  +     V  +    A +
Sbjct: 324 TSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQV 383

Query: 683 SVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTA 742
              D   + PL+ A     +D+  TL++ G               +LLH A    N    
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG----HSLLHWAALGGNADVC 439

Query: 743 CFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDA 802
             LI +  + N             +   G+TPL  AA  G    +  L+E  A+ N QD 
Sbjct: 440 QILIENKINPNV------------QDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDK 487

Query: 803 EGRTPIHVAISSQHGVIIQLLV 824
           EGRT +H + ++ +   I+LL+
Sbjct: 488 EGRTALHWSCNNGYLDAIKLLL 509



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 87/385 (22%), Positives = 147/385 (38%), Gaps = 41/385 (10%)

Query: 221 PLHKAIKVEREDVVFLYLIEMDSQ-LPGKLNEADHNGDLALDLALSRRLESIATTLVSHK 279
           PLH A   +    V      +D+      LN  D+ G   L  A++    ++   L S++
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244

Query: 280 A-DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKH 338
           + ++   D    + LH     G       L++        +     TPLH  A       
Sbjct: 245 SCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAA------- 297

Query: 339 SADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQ-LDLELK 397
                S  A+  +  L+  +  +  D +GRT    +   G++ V   +L  K  +D+ + 
Sbjct: 298 ----QSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMA 353

Query: 398 DHEGSTALWLAVQHITVSSDQ----------SVNPFEDVPVVNGTSFDENSFAARLIQRG 447
           D  G TAL  A     VS+ +          + +  +  P+              LI+ G
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413

Query: 448 SHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLT 507
           +  D  D   G+ LL  AA  GN      L  N  + N ++  G TPL  A   G  N  
Sbjct: 414 ARVDLVDQ-DGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCM 472

Query: 508 AELLQQGANPNLQTEE---------------ALPLPKE-AASLTSLADSVHLQTPLHMAI 551
           A L++  A+PN+Q +E               A+ L  + AA    + ++    TPL  A+
Sbjct: 473 AVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532

Query: 552 AYNHPDVVSVILEQKANALHATNNL 576
                +V+  +LE  A ++ A  ++
Sbjct: 533 LGERHEVIQFMLEHGALSIAAIQDI 557


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 98/400 (24%), Positives = 156/400 (39%), Gaps = 88/400 (22%)

Query: 465 AAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEA 524
           AAG GN      L   G+ ++ ++K G   ++ A RHG  + T + L +   P       
Sbjct: 386 AAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD-TLKFLSENKCP------- 437

Query: 525 LPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSL 584
           L +  ++  +            LH+A  Y H DV  ++    +N              ++
Sbjct: 438 LDVKDKSGEMA-----------LHVAARYGHADVAQLLCSFGSNP-------------NI 473

Query: 585 KDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEH 644
           +D  ++T L  A W G +++A  L  +G  +N    +G+T L  A  R        L EH
Sbjct: 474 QDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEH 533

Query: 645 QADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDI 704
            AD+N    +DG  AL LA+R     V+  + ++G  +   D  GN PL           
Sbjct: 534 GADLNAC-DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPL----------- 581

Query: 705 ASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEG 764
                                     H A  + N P    L  + C+++           
Sbjct: 582 --------------------------HVACKDGNMPIVVALCEANCNLDISN-------- 607

Query: 765 EEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV 824
               + G+TPLHLAA+ G+ + V+ L   GA+V A   +G+T   +A S QH  +  LL 
Sbjct: 608 ----KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLA 663

Query: 825 S-HPDIH-----LNVRDRQGLTPFACAMTFKNNKSAEAIL 858
               D H       +R  Q L P      F ++ S +  L
Sbjct: 664 RLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTL 703



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 83/302 (27%), Positives = 132/302 (43%), Gaps = 24/302 (7%)

Query: 681 DMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEP 740
           D++ P++ G PPL +A       I   L++ G        G    +    + A    +  
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAV----YWAARHGHVD 426

Query: 741 TACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQ 800
           T  FL  + C +            + + + G+  LH+AA +G  +  Q L  FG+N N Q
Sbjct: 427 TLKFLSENKCPL------------DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQ 474

Query: 801 DAEGRTPIHVAISSQHGVI-IQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILK 859
           D E  TP+H A  + HG   +   +     ++N+++R+G TP   A     +   E +  
Sbjct: 475 DKEEETPLHCA--AWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLA- 531

Query: 860 RESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAG 918
            E GA     D  G   LH+AV+   +E +  L+S    V+   QD    TPLH+A + G
Sbjct: 532 -EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD--YQDRHGNTPLHVACKDG 588

Query: 919 SEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALH 978
           +  IV  L  A   ++   K+ +T LHLAA   +  +   L   G    A+  +G  A  
Sbjct: 589 NMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAED 648

Query: 979 LA 980
           LA
Sbjct: 649 LA 650



 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 96/356 (26%), Positives = 152/356 (42%), Gaps = 60/356 (16%)

Query: 726  LQTLLHRAIDENNEPTACFLIRS--GCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGL 783
            ++ ++H AI+++N P    L+ S    DVN P             + G  PL +AA  G 
Sbjct: 345  MKAIIH-AINDDNVPGLQHLLGSLSNYDVNQPN------------KHGTPPLLIAAGCGN 391

Query: 784  EETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFA 843
             + +Q L++ G+ ++ QD  G   ++ A  ++HG +  L              + L+   
Sbjct: 392  IQILQLLIKRGSRIDVQDKGGSNAVYWA--ARHGHVDTL--------------KFLSENK 435

Query: 844  CAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQ 903
            C +  K                   D  G   LHVA +    +    L S  +N N  +Q
Sbjct: 436  CPLDVK-------------------DKSGEMALHVAARYGHADVAQLLCSFGSNPN--IQ 474

Query: 904  DASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENG 963
            D  + TPLH A   G   + + L  AG  VN   +  +T L  A+ +    I   L E+G
Sbjct: 475  DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534

Query: 964  VDFAAVDENGNNALHLAVMHGRLNNIRVLLTE-CTVDAEAFNLRGQSPLHILGQYGKENA 1022
             D  A D++G+ ALHLAV   ++  I+ LL++ C VD +  +  G +PLH+  + G  N 
Sbjct: 535  ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ--DRHGNTPLHVACKDG--NM 590

Query: 1023 AAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
              +  L   C     LD  +  G T L LA   G  ++ R +   GA +      G
Sbjct: 591  PIVVAL---CEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDG 643



 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 75/271 (27%), Positives = 119/271 (43%), Gaps = 36/271 (13%)

Query: 443 LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHG 502
           LI+RGS  D  D    N +   AA  G+     FL+ N   ++ ++K GE  LH A R+G
Sbjct: 398 LIKRGSRIDVQDKGGSNAVYW-AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYG 456

Query: 503 LANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVI 562
            A++   L   G+NPN+Q +E                    +TPLH A  + +  V   +
Sbjct: 457 HADVAQLLCSFGSNPNIQDKEE-------------------ETPLHCAAWHGYYSVAKAL 497

Query: 563 LEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDG 622
            E   N              ++K+   +T L  A   G H I   L   GA +N    DG
Sbjct: 498 CEAGCNV-------------NIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDG 544

Query: 623 QTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRN-QLPLVVDAICTRGAD 681
              LH+A++R   +    LL     ++  + + G T L +A ++  +P+VV A+C    +
Sbjct: 545 HIALHLAVRRCQMEVIKTLLSQGCFVDY-QDRHGNTPLHVACKDGNMPIVV-ALCEANCN 602

Query: 682 MSVPDEKGNPPLWLALANNLEDIASTLVRHG 712
           + + ++ G  PL LA  N + D+   L   G
Sbjct: 603 LDISNKYGRTPLHLAANNGILDVVRYLCLMG 633



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 90/365 (24%), Positives = 147/365 (40%), Gaps = 87/365 (23%)

Query: 595 LALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQ 654
           +A   G   I   L+  G+ I+     G   ++ A +     +  FL E++  ++V + +
Sbjct: 385 IAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDV-KDK 443

Query: 655 DGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCD 714
            GE AL +A R     V   +C+ G++ ++ D++   PL  A  +    +A  L    C+
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL----CE 499

Query: 715 ATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTP 774
           A                                 GC+VN               R+G+TP
Sbjct: 500 A---------------------------------GCNVNIKN------------REGETP 514

Query: 775 LHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVR 834
           L  A++ G  + V+CL E GA++NA D +G   +H+A+      +I+ L+S     ++ +
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ-GCFVDYQ 573

Query: 835 DRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISV 894
           DR G TP                                  LHVA ++ ++  V+ L   
Sbjct: 574 DRHGNTP----------------------------------LHVACKDGNMPIVVALCE- 598

Query: 895 HANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPT 954
            AN N  + +    TPLHLA   G   +VR L L GA V  LT   +TA  LA  +    
Sbjct: 599 -ANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEH 657

Query: 955 ICSVL 959
           +  +L
Sbjct: 658 VAGLL 662



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 87/350 (24%), Positives = 135/350 (38%), Gaps = 58/350 (16%)

Query: 361 NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSV 420
           N  +  G  PL ++   GN  +  QLL  +   ++++D  GS A++ A +H  V      
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQIL-QLLIKRGSRIDVQDKGGSNAVYWAARHGHV------ 425

Query: 421 NPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATN 480
                         D   F   L +     D  D + G   L  AA  G+   A  L + 
Sbjct: 426 --------------DTLKF---LSENKCPLDVKDKS-GEMALHVAARYGHADVAQLLCSF 467

Query: 481 GAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS 540
           G++ N ++K  ETPLH A  HG  ++   L + G N N++  E                 
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG---------------- 511

Query: 541 VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTG 600
              +TPL  A A  + D+V  + E  A             D +  D      L LA+   
Sbjct: 512 ---ETPLLTASARGYHDIVECLAEHGA-------------DLNACDKDGHIALHLAVRRC 555

Query: 601 MHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETAL 660
              +   LL  G  ++     G T LH+A +  +    + L E   ++++S  + G T L
Sbjct: 556 QMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS-NKYGRTPL 614

Query: 661 QLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVR 710
            LA  N +  VV  +C  GA +      G     LA +   E +A  L R
Sbjct: 615 HLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 77/347 (22%), Positives = 135/347 (38%), Gaps = 57/347 (16%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           +N+ + +G   L +A       I   L+   + +D+ DK G + ++   + G +    FL
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
            +N   ++       E  LH+ A Y             A +A+ L   G+NPN+QD +  
Sbjct: 432 SENKCPLDVKDKSG-EMALHVAARYGH-----------ADVAQLLCSFGSNPNIQDKEEE 479

Query: 369 TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPV 428
           TPLH +   G   V   L +    ++ +K+ EG T L  A          S   + D+  
Sbjct: 480 TPLHCAAWHGYYSVAKALCEA-GCNVNIKNREGETPLLTA----------SARGYHDI-- 526

Query: 429 VNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRN 488
                         L + G+  +A D   G+  L  A           L + G  V++++
Sbjct: 527 -----------VECLAEHGADLNACD-KDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574

Query: 489 KWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLH 548
           + G TPLH AC+ G   +   L +   N ++  +                   + +TPLH
Sbjct: 575 RHGNTPLHVACKDGNMPIVVALCEANCNLDISNK-------------------YGRTPLH 615

Query: 549 MAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGL 595
           +A      DVV  +    A+    T + +   D + +  + + V GL
Sbjct: 616 LAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA-RSEQHEHVAGL 661



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 23/95 (24%), Positives = 49/95 (51%), Gaps = 7/95 (7%)

Query: 987  NNIRVLLTECTVDAE-AFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADG 1045
            +N+ V  ++ T+D E +F ++      I+     +N   +  L L  +  Y +++P+  G
Sbjct: 326  SNMSVARSDDTLDEEDSFVMKA-----IIHAINDDNVPGLQHL-LGSLSNYDVNQPNKHG 379

Query: 1046 STVLLLAYMKGNANLCRAIVRSGARLGVNNNQGVN 1080
            +  LL+A   GN  + + +++ G+R+ V +  G N
Sbjct: 380  TPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSN 414


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 140/540 (25%), Positives = 202/540 (37%), Gaps = 82/540 (15%)

Query: 470 NEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPK 529
           +EAAA        + ++  +     L  AC  G  N   +LL +G + N  TEE   L  
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243

Query: 530 EAAS-----LTSLADSVHLQ----------TPLHMAIAYNHPDVVSVILEQKANALHATN 574
            A S     L  +  ++H            TPL  A +  + D+V ++L   A       
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA------- 296

Query: 575 NLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQD 634
                 D + + +   T L  A   G   I   LL  GA I D   +G T L  A     
Sbjct: 297 ------DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH 350

Query: 635 SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
            + A  LL+H A IN    +  E+AL LA       +V  +   GAD     ++ +  L 
Sbjct: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 410

Query: 695 LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 754
            A  +   ++A  L+  G         P    ++ L  A    +   A  LI  G ++  
Sbjct: 411 EACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLAACGGHVELAALLIERGANL-- 464

Query: 755 PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGR--------- 805
                     EE   +G TPL  AA  G EE V  LL  GAN+NAQ  E +         
Sbjct: 465 ----------EEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514

Query: 806 ----------------------TPIHVAISSQHGVIIQ-LLVSHPDIHLNVRDRQGLTPF 842
                                 TP+  A    H  +++ LL S  ++H           +
Sbjct: 515 GGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTY 574

Query: 843 ACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
           AC    +N  +  A +  ++GA  E     GR  L  A +   + +V FLIS  ANVN R
Sbjct: 575 AC----ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN-R 629

Query: 902 VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961
               +  T + LA   G   +V  LL  GA      K   T L  AA+     + S LL+
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 99/376 (26%), Positives = 146/376 (38%), Gaps = 47/376 (12%)

Query: 451  DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAEL 510
            DA   +  +  L  A   G+E     L    A + HR+K G TPL  A   G   +   L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107

Query: 511  LQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANAL 570
            L +G +   Q+E                      TPL +A +    +VV ++L + AN  
Sbjct: 1108 LDKGGDIEAQSERTK------------------DTPLSLACSGGRQEVVDLLLARGANKE 1149

Query: 571  HATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSD--GQTLLHM 628
            H             ++  D T L LA   G   I   LL +GA IN       G + L +
Sbjct: 1150 H-------------RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1196

Query: 629  AIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEK 688
            A       +   LL+  +DIN     +  TAL LA       VV  +  R A++    + 
Sbjct: 1197 AAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT 1256

Query: 689  GNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRS 748
            G  PL  A +    ++   L+  G D     P       T L  A D+ +      LI  
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNA--PPVPSSRDTALTIAADKGHYKFCELLIHR 1314

Query: 749  GCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPI 808
            G  +            +   + G TPL LA++ G  + VQ L++ GA+V+A D    TP+
Sbjct: 1315 GAHI------------DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362

Query: 809  HVAISSQHGVIIQLLV 824
              A    H  ++Q LV
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 103/407 (25%), Positives = 162/407 (39%), Gaps = 23/407 (5%)

Query: 590 QTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSAL-FLLEHQADI 648
           +++L LA   G + +A  LL   A + D  + G     MA         +  LL H AD+
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 298

Query: 649 NVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTL 708
           N S++  G TAL  A       +V  +   GA++   +E G+ PL  A +    ++A  L
Sbjct: 299 N-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357

Query: 709 VRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEA 768
           + HG              ++ L  A  + +     FL+ +G D             E + 
Sbjct: 358 LDHGAGINTHS---NEFKESALTLACYKGHLDMVRFLLEAGADQ------------EHKT 402

Query: 769 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPD 828
            +  T L  A   G  E  + LL+ GA VN       +P+ +A    H  +  LL+    
Sbjct: 403 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 829 IHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESV 888
               V D +G TP   A    + +    +L + +    Q +      L +A      E  
Sbjct: 463 NLEEVND-EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521

Query: 889 LFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAA 948
            FLI   A++     +    TPL  A Q G   +V+ LL +GA V+  T    TAL  A 
Sbjct: 522 DFLIKAGADI-----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576

Query: 949 QQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTE 995
           +     +  VLL+ G D     E G   L  A   G L  ++ L+++
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 124/486 (25%), Positives = 187/486 (38%), Gaps = 53/486 (10%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADV-DMVDKSGWSLLHKGIQRGDLFAATF 307
           +NE    G+  L LA S     +A  L++  A+V D  +K   + L      G L     
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 308 LIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
           L+ + A VN+ +        +  A                 I + LL  GAN    +  G
Sbjct: 291 LLLHDADVNSQSATGNTALTYACA------------GGFVDIVKVLLNEGANIEDHNENG 338

Query: 368 RTPLHVSIMAGNEYVFSQLL-----------QCKQLDLELKDHEGSTALWLAVQHITVSS 416
            TPL  +  AG+  V   LL           + K+  L L  ++G   +   +  +   +
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL--LEAGA 396

Query: 417 DQSVNPFEDVPVVNGTSFDENSFAARLI-QRGSHTDAPDTATGNCLLQRAAGAGNEAAAL 475
           DQ     E    +     D +   ARL+   G+  + P  +  + L   A G   E AAL
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 476 FLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAA--- 532
            L   GA++   N  G TPL  A R G   + A LL QGAN N QTEE        A   
Sbjct: 457 -LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515

Query: 533 SLTSLAD---------SVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 583
             + +AD          +   TPL  A    H ++V  +L   AN +HAT          
Sbjct: 516 GFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN-VHATT--------- 565

Query: 584 LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 643
              +   T L  A   G   +A  LL +GA +      G+T L  A +     +  FL+ 
Sbjct: 566 ---ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622

Query: 644 HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLED 703
             A++N +   +  T + LA       VV+ +   GAD +   + G+  L  A      +
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTN 682

Query: 704 IASTLV 709
           + S L+
Sbjct: 683 VVSYLL 688



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 97/368 (26%), Positives = 149/368 (40%), Gaps = 54/368 (14%)

Query: 647  DINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIAS 706
            DI+     + +TAL LA       +V  +  R A +   D+KG  PL LA          
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAAT-------- 1097

Query: 707  TLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEE 766
                          G  G ++ LL +                          G + E + 
Sbjct: 1098 -------------AGHVGVVEILLDK--------------------------GGDIEAQS 1118

Query: 767  EARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV-S 825
            E R   TPL LA S G +E V  LL  GAN   ++    TP+ +A S  +  II++L+ +
Sbjct: 1119 E-RTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 826  HPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDI 885
              +I+     + G++P   A    +  + + +L   S    Q++      L +A      
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 886  ESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN--ELTKHRQTA 943
            E V  L+   ANV  R +  + LTPL  A   G   + R LL  GA VN   +   R TA
Sbjct: 1238 EVVSLLLDRKANVEHRAK--TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295

Query: 944  LHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAF 1003
            L +AA +     C +L+  G      ++ GN  L LA   G  + ++ LL +   D +A 
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ-LLVQAGADVDAA 1354

Query: 1004 NLRGQSPL 1011
            + R  +PL
Sbjct: 1355 DNRKITPL 1362



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 93/388 (23%), Positives = 149/388 (38%), Gaps = 45/388 (11%)

Query: 341  DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
            D + ++       +  G+N + Q ++  TP   S    N  V SQ +      +++  H 
Sbjct: 994  DTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSN--VASQSMPPVYPSVDIDAHT 1051

Query: 401  GS---TALWLA-------VQHITVSSDQSVNPFED---VPVVNGTSFDENSFAARLIQRG 447
             S   TAL LA       +  + ++ D  +   +     P++   +         L+ +G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 448  SHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLT 507
               +A    T +  L  A   G +     L   GA+  HRN    TPL  A   G  N+ 
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 508  AELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKA 567
              LL  GA  N +T   L +                 +PL +A    H   V ++L+  +
Sbjct: 1172 KILLNAGAEINSRTGSKLGI-----------------SPLMLAAMNGHVPAVKLLLDMGS 1214

Query: 568  NALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLH 627
            +      N QI       ++   T L LA + G   + + LL   A +      G T L 
Sbjct: 1215 DI-----NAQI-------ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262

Query: 628  MAIQRQDSKSALFLLEHQADINVSRTQDG-ETALQLAIRNQLPLVVDAICTRGADMSVPD 686
             A     ++    LL+  AD+N        +TAL +A         + +  RGA + V +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 687  EKGNPPLWLALANNLEDIASTLVRHGCD 714
            +KGN PLWLA      D+   LV+ G D
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGAD 1350



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 110/493 (22%), Positives = 189/493 (38%), Gaps = 83/493 (16%)

Query: 232 DVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWS 291
           D+V L L+         +N     G+ AL  A +     I   L++  A+++  +++G +
Sbjct: 286 DIVKLLLLH-----DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340

Query: 292 LLHKGIQRGDLFAATFLIKNGAFVN---------AATLGAQETPLHLVALY----SSKKH 338
            L +    G +  A  L+ +GA +N         A TL   +  L +V       + ++H
Sbjct: 341 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400

Query: 339 SADVMSEM---------AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQC 389
             D M             ++A  LL +GA  NM      +PL ++   G+  + + L++ 
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE- 459

Query: 390 KQLDLELKDHEGSTALWLAVQH-----ITVSSDQSVNPFEDVPVVNGTSFDENSFAARLI 444
           +  +LE  + EG T L  A +      + +   Q  N       +N  + +    A  L 
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN-------INAQTEETQETALTLA 512

Query: 445 QRGSHTDAPDTATG---------NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPL 495
             G  ++  D             +  L  A+  G+     +L  +GA+V+     G+T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 496 HTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNH 555
             AC +G  ++   LLQ GA+   ++E                     +TPL  A    H
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGG-------------------RTPLMKAARAGH 613

Query: 556 PDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAI 615
              V  ++ + AN   AT N             D TV+ LA   G   +   LL  GA  
Sbjct: 614 LCTVQFLISKGANVNRATAN------------NDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 616 NDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAI 675
              + DG T+L  A +   +    +LL++  ++    T D     QL   +Q    V  +
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTD---VSQLPPPSQDQSQVPRV 718

Query: 676 CTRGADMSVPDEK 688
            T    M VP ++
Sbjct: 719 PTHTLAMVVPPQE 731



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 86/329 (26%), Positives = 144/329 (43%), Gaps = 13/329 (3%)

Query: 755  PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS 814
            P  P  + +   E+    T L LA + G EE V  L+   A +  +D +G TP+ +A ++
Sbjct: 1040 PVYPSVDIDAHTESNH-DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATA 1098

Query: 815  QH-GVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN-KG 872
             H GV+  LL    DI     +R   TP + A +    +  + +L R  GA ++  N   
Sbjct: 1099 GHVGVVEILLDKGGDIEAQ-SERTKDTPLSLACSGGRQEVVDLLLAR--GANKEHRNVSD 1155

Query: 873  RNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAK 932
               L +A     +  +  L++  A +NSR      ++PL LA   G    V+ LL  G+ 
Sbjct: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215

Query: 933  VN-ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRV 991
            +N ++  +R TAL LA  Q    + S+LL+   +     + G   L  A   G     RV
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275

Query: 992  LLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLL 1050
            LL +   V+A        + L I    G      +         G  +D  +  G+T L 
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL-----IHRGAHIDVRNKKGNTPLW 1330

Query: 1051 LAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
            LA   G+ ++ + +V++GA +   +N+ +
Sbjct: 1331 LASNGGHFDVVQLLVQAGADVDAADNRKI 1359



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 86/349 (24%), Positives = 134/349 (38%), Gaps = 60/349 (17%)

Query: 253  DHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNG 312
            + N D AL LA +   E + + L++  A ++  DK G++ L      G +     L+  G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 313  AFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLH 372
              + A +   ++TPL L                  ++ + LL  GAN   ++    TPL 
Sbjct: 1112 GDIEAQSERTKDTPLSLAC-----------SGGRQEVVDLLLARGANKEHRNVSDYTPLS 1160

Query: 373  VSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGT 432
            ++   G   +   LL       E+    GS    L +  + +++         VP V   
Sbjct: 1161 LAASGGYVNIIKILLNA---GAEINSRTGSK---LGISPLMLAAMNG-----HVPAVK-- 1207

Query: 433  SFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGE 492
                      L+  GS  +A      N  L  A   G       L    A+V HR K G 
Sbjct: 1208 ---------LLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGL 1258

Query: 493  TPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEA-ASLTSLADSVHLQ------- 544
            TPL  A   G A +   LL +GA+ N     A P+P     +LT  AD  H +       
Sbjct: 1259 TPLMEAASGGYAEVGRVLLDKGADVN-----APPVPSSRDTALTIAADKGHYKFCELLIH 1313

Query: 545  -------------TPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIP 580
                         TPL +A    H DVV ++++  A+ + A +N +I P
Sbjct: 1314 RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD-VDAADNRKITP 1361



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 74/335 (22%), Positives = 130/335 (38%), Gaps = 54/335 (16%)

Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
           +A  L+   A+++ V+  G++ L +  + G       L+  GA +NA T   QET L L 
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
                           +++A+ L++AGA+  +  S   TPL  +   G+  +   LL   
Sbjct: 513 CC-----------GGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLL-AS 557

Query: 391 QLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAAR-------- 442
             ++      G TAL       T + +       DV +  G   +  S   R        
Sbjct: 558 GANVHATTATGDTAL-------TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610

Query: 443 ---------LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGET 493
                    LI +G++ +       + ++  A   G+ A    L  +GA   HR K G T
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670

Query: 494 PLHTACRHGLANLTAELLQQGANP-NLQTEEALPLPKEAASLTSLADSVHLQTPLH---M 549
            L  A + G  N+ + LL    N  ++ T +   LP  +   + +      + P H   M
Sbjct: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVP-----RVPTHTLAM 725

Query: 550 AIAYNHPDVVS------VILEQKANALHATNNLQI 578
            +    PD  S      ++  QK  +   +++LQ+
Sbjct: 726 VVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQV 760



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 47/180 (26%), Positives = 85/180 (47%), Gaps = 18/180 (10%)

Query: 238  LIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGI 297
            L++M S +  ++   + N + AL LA  +    + + L+  KA+V+   K+G + L +  
Sbjct: 1209 LLDMGSDINAQI---ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265

Query: 298  QRGDLFAATFLIKNGAFVNAATL-GAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQA 356
              G       L+  GA VNA  +  +++T L + A    K H         +  E L+  
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA---DKGH--------YKFCELLIHR 1314

Query: 357  GANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITV 414
            GA+ ++++ KG TPL ++   G+  V   L+Q    D++  D+   T L  A +  H+ V
Sbjct: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA-GADVDAADNRKITPLMSAFRKGHVKV 1373



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 9/182 (4%)

Query: 909  TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAA 968
            T L LA   G E +V  L+   AK+    K   T L LAA      +  +LL+ G D  A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 969  VDENGNNA-LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFD 1027
              E   +  L LA   GR   + +LL     + E  N+   +PL +    G  N   I  
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVN---IIK 1172

Query: 1028 LFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSG----ARLGVNNNQGVNIFN 1083
            + L              G + L+LA M G+    + ++  G    A++  N N  + +  
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232

Query: 1084 YQ 1085
            +Q
Sbjct: 1233 FQ 1234



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 41/168 (24%), Positives = 69/168 (41%), Gaps = 13/168 (7%)

Query: 914  AVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENG 973
            A   G    VR LL  G  VNE T+  ++ L LA       +  VLL      A V++ G
Sbjct: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL---AMHANVEDRG 268

Query: 974  NNA----LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLF 1029
            N      L  A   G L+ +++LL     D  + +  G + L      G  +   +    
Sbjct: 269  NKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKVL--- 324

Query: 1030 LECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQ 1077
                 G  ++  + +G T L+ A   G+  + R ++  GA +  ++N+
Sbjct: 325  --LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 140/540 (25%), Positives = 202/540 (37%), Gaps = 82/540 (15%)

Query: 470 NEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPK 529
           +EAAA        + ++  +     L  AC  G  N   +LL +G + N  TEE   L  
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243

Query: 530 EAAS-----LTSLADSVHLQ----------TPLHMAIAYNHPDVVSVILEQKANALHATN 574
            A S     L  +  ++H            TPL  A +  + D+V ++L   A       
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA------- 296

Query: 575 NLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQD 634
                 D + + +   T L  A   G   I   LL  GA I D   +G T L  A     
Sbjct: 297 ------DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH 350

Query: 635 SKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLW 694
            + A  LL+H A IN    +  E+AL LA       +V  +   GAD     ++ +  L 
Sbjct: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALM 410

Query: 695 LALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNS 754
            A  +   ++A  L+  G         P    ++ L  A    +   A  LI  G ++  
Sbjct: 411 EACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLAACGGHVELAALLIERGANL-- 464

Query: 755 PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGR--------- 805
                     EE   +G TPL  AA  G EE V  LL  GAN+NAQ  E +         
Sbjct: 465 ----------EEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514

Query: 806 ----------------------TPIHVAISSQHGVIIQ-LLVSHPDIHLNVRDRQGLTPF 842
                                 TP+  A    H  +++ LL S  ++H           +
Sbjct: 515 GGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTY 574

Query: 843 ACAMTFKNNKSAEAILKRESGA-AEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR 901
           AC    +N  +  A +  ++GA  E     GR  L  A +   + +V FLIS  ANVN R
Sbjct: 575 AC----ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN-R 629

Query: 902 VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLE 961
               +  T + LA   G   +V  LL  GA      K   T L  AA+     + S LL+
Sbjct: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 99/376 (26%), Positives = 146/376 (38%), Gaps = 47/376 (12%)

Query: 451  DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAEL 510
            DA   +  +  L  A   G+E     L    A + HR+K G TPL  A   G   +   L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107

Query: 511  LQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANAL 570
            L +G +   Q+E                      TPL +A +    +VV ++L + AN  
Sbjct: 1108 LDKGGDIEAQSERTK------------------DTPLSLACSGGRQEVVDLLLARGANKE 1149

Query: 571  HATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSD--GQTLLHM 628
            H             ++  D T L LA   G   I   LL +GA IN       G + L +
Sbjct: 1150 H-------------RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLML 1196

Query: 629  AIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEK 688
            A       +   LL+  +DIN     +  TAL LA       VV  +  R A++    + 
Sbjct: 1197 AAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT 1256

Query: 689  GNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRS 748
            G  PL  A +    ++   L+  G D     P       T L  A D+ +      LI  
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNA--PPVPSSRDTALTIAADKGHYKFCELLIHR 1314

Query: 749  GCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPI 808
            G  +            +   + G TPL LA++ G  + VQ L++ GA+V+A D    TP+
Sbjct: 1315 GAHI------------DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362

Query: 809  HVAISSQHGVIIQLLV 824
              A    H  ++Q LV
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 103/407 (25%), Positives = 162/407 (39%), Gaps = 23/407 (5%)

Query: 590 QTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSAL-FLLEHQADI 648
           +++L LA   G + +A  LL   A + D  + G     MA         +  LL H AD+
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 298

Query: 649 NVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTL 708
           N S++  G TAL  A       +V  +   GA++   +E G+ PL  A +    ++A  L
Sbjct: 299 N-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357

Query: 709 VRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEA 768
           + HG              ++ L  A  + +     FL+ +G D             E + 
Sbjct: 358 LDHGAGINTHS---NEFKESALTLACYKGHLDMVRFLLEAGADQ------------EHKT 402

Query: 769 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPD 828
            +  T L  A   G  E  + LL+ GA VN       +P+ +A    H  +  LL+    
Sbjct: 403 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462

Query: 829 IHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESV 888
               V D +G TP   A    + +    +L + +    Q +      L +A      E  
Sbjct: 463 NLEEVND-EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521

Query: 889 LFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAA 948
            FLI   A++     +    TPL  A Q G   +V+ LL +GA V+  T    TAL  A 
Sbjct: 522 DFLIKAGADI-----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576

Query: 949 QQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTE 995
           +     +  VLL+ G D     E G   L  A   G L  ++ L+++
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 124/486 (25%), Positives = 187/486 (38%), Gaps = 53/486 (10%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADV-DMVDKSGWSLLHKGIQRGDLFAATF 307
           +NE    G+  L LA S     +A  L++  A+V D  +K   + L      G L     
Sbjct: 231 VNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKL 290

Query: 308 LIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
           L+ + A VN+ +        +  A                 I + LL  GAN    +  G
Sbjct: 291 LLLHDADVNSQSATGNTALTYACA------------GGFVDIVKVLLNEGANIEDHNENG 338

Query: 368 RTPLHVSIMAGNEYVFSQLL-----------QCKQLDLELKDHEGSTALWLAVQHITVSS 416
            TPL  +  AG+  V   LL           + K+  L L  ++G   +   +  +   +
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL--LEAGA 396

Query: 417 DQSVNPFEDVPVVNGTSFDENSFAARLI-QRGSHTDAPDTATGNCLLQRAAGAGNEAAAL 475
           DQ     E    +     D +   ARL+   G+  + P  +  + L   A G   E AAL
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456

Query: 476 FLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAA--- 532
            L   GA++   N  G TPL  A R G   + A LL QGAN N QTEE        A   
Sbjct: 457 -LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515

Query: 533 SLTSLAD---------SVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFS 583
             + +AD          +   TPL  A    H ++V  +L   AN +HAT          
Sbjct: 516 GFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN-VHATT--------- 565

Query: 584 LKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLE 643
              +   T L  A   G   +A  LL +GA +      G+T L  A +     +  FL+ 
Sbjct: 566 ---ATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622

Query: 644 HQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLED 703
             A++N +   +  T + LA       VV+ +   GAD +   + G+  L  A      +
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTN 682

Query: 704 IASTLV 709
           + S L+
Sbjct: 683 VVSYLL 688



 Score = 87.0 bits (214), Expect = 9e-17
 Identities = 97/368 (26%), Positives = 149/368 (40%), Gaps = 54/368 (14%)

Query: 647  DINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIAS 706
            DI+     + +TAL LA       +V  +  R A +   D+KG  PL LA          
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAAT-------- 1097

Query: 707  TLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEE 766
                          G  G ++ LL +                          G + E + 
Sbjct: 1098 -------------AGHVGVVEILLDK--------------------------GGDIEAQS 1118

Query: 767  EARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV-S 825
            E R   TPL LA S G +E V  LL  GAN   ++    TP+ +A S  +  II++L+ +
Sbjct: 1119 E-RTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 826  HPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDI 885
              +I+     + G++P   A    +  + + +L   S    Q++      L +A      
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 886  ESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVN--ELTKHRQTA 943
            E V  L+   ANV  R +  + LTPL  A   G   + R LL  GA VN   +   R TA
Sbjct: 1238 EVVSLLLDRKANVEHRAK--TGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295

Query: 944  LHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAF 1003
            L +AA +     C +L+  G      ++ GN  L LA   G  + ++ LL +   D +A 
Sbjct: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ-LLVQAGADVDAA 1354

Query: 1004 NLRGQSPL 1011
            + R  +PL
Sbjct: 1355 DNRKITPL 1362



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 93/388 (23%), Positives = 149/388 (38%), Gaps = 45/388 (11%)

Query: 341  DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE 400
            D + ++       +  G+N + Q ++  TP   S    N  V SQ +      +++  H 
Sbjct: 994  DTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSN--VASQSMPPVYPSVDIDAHT 1051

Query: 401  GS---TALWLA-------VQHITVSSDQSVNPFED---VPVVNGTSFDENSFAARLIQRG 447
             S   TAL LA       +  + ++ D  +   +     P++   +         L+ +G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 448  SHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLT 507
               +A    T +  L  A   G +     L   GA+  HRN    TPL  A   G  N+ 
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 508  AELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKA 567
              LL  GA  N +T   L +                 +PL +A    H   V ++L+  +
Sbjct: 1172 KILLNAGAEINSRTGSKLGI-----------------SPLMLAAMNGHVPAVKLLLDMGS 1214

Query: 568  NALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLH 627
            +      N QI       ++   T L LA + G   + + LL   A +      G T L 
Sbjct: 1215 DI-----NAQI-------ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262

Query: 628  MAIQRQDSKSALFLLEHQADINVSRTQDG-ETALQLAIRNQLPLVVDAICTRGADMSVPD 686
             A     ++    LL+  AD+N        +TAL +A         + +  RGA + V +
Sbjct: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322

Query: 687  EKGNPPLWLALANNLEDIASTLVRHGCD 714
            +KGN PLWLA      D+   LV+ G D
Sbjct: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGAD 1350



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 110/493 (22%), Positives = 189/493 (38%), Gaps = 83/493 (16%)

Query: 232 DVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWS 291
           D+V L L+         +N     G+ AL  A +     I   L++  A+++  +++G +
Sbjct: 286 DIVKLLLLH-----DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340

Query: 292 LLHKGIQRGDLFAATFLIKNGAFVN---------AATLGAQETPLHLVALY----SSKKH 338
            L +    G +  A  L+ +GA +N         A TL   +  L +V       + ++H
Sbjct: 341 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400

Query: 339 SADVMSEM---------AQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQC 389
             D M             ++A  LL +GA  NM      +PL ++   G+  + + L++ 
Sbjct: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE- 459

Query: 390 KQLDLELKDHEGSTALWLAVQH-----ITVSSDQSVNPFEDVPVVNGTSFDENSFAARLI 444
           +  +LE  + EG T L  A +      + +   Q  N       +N  + +    A  L 
Sbjct: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN-------INAQTEETQETALTLA 512

Query: 445 QRGSHTDAPDTATG---------NCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPL 495
             G  ++  D             +  L  A+  G+     +L  +GA+V+     G+T L
Sbjct: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572

Query: 496 HTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNH 555
             AC +G  ++   LLQ GA+   ++E                     +TPL  A    H
Sbjct: 573 TYACENGHTDVADVLLQAGADLEHESEGG-------------------RTPLMKAARAGH 613

Query: 556 PDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAI 615
              V  ++ + AN   AT N             D TV+ LA   G   +   LL  GA  
Sbjct: 614 LCTVQFLISKGANVNRATAN------------NDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 616 NDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAI 675
              + DG T+L  A +   +    +LL++  ++    T D     QL   +Q    V  +
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTD---VSQLPPPSQDQSQVPRV 718

Query: 676 CTRGADMSVPDEK 688
            T    M VP ++
Sbjct: 719 PTHTLAMVVPPQE 731



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 86/329 (26%), Positives = 144/329 (43%), Gaps = 13/329 (3%)

Query: 755  PRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISS 814
            P  P  + +   E+    T L LA + G EE V  L+   A +  +D +G TP+ +A ++
Sbjct: 1040 PVYPSVDIDAHTESNH-DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATA 1098

Query: 815  QH-GVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN-KG 872
             H GV+  LL    DI     +R   TP + A +    +  + +L R  GA ++  N   
Sbjct: 1099 GHVGVVEILLDKGGDIEAQ-SERTKDTPLSLACSGGRQEVVDLLLAR--GANKEHRNVSD 1155

Query: 873  RNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAK 932
               L +A     +  +  L++  A +NSR      ++PL LA   G    V+ LL  G+ 
Sbjct: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215

Query: 933  VN-ELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRV 991
            +N ++  +R TAL LA  Q    + S+LL+   +     + G   L  A   G     RV
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275

Query: 992  LLTE-CTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLL 1050
            LL +   V+A        + L I    G      +         G  +D  +  G+T L 
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL-----IHRGAHIDVRNKKGNTPLW 1330

Query: 1051 LAYMKGNANLCRAIVRSGARLGVNNNQGV 1079
            LA   G+ ++ + +V++GA +   +N+ +
Sbjct: 1331 LASNGGHFDVVQLLVQAGADVDAADNRKI 1359



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 86/349 (24%), Positives = 134/349 (38%), Gaps = 60/349 (17%)

Query: 253  DHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNG 312
            + N D AL LA +   E + + L++  A ++  DK G++ L      G +     L+  G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 313  AFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLH 372
              + A +   ++TPL L                  ++ + LL  GAN   ++    TPL 
Sbjct: 1112 GDIEAQSERTKDTPLSLAC-----------SGGRQEVVDLLLARGANKEHRNVSDYTPLS 1160

Query: 373  VSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGT 432
            ++   G   +   LL       E+    GS    L +  + +++         VP V   
Sbjct: 1161 LAASGGYVNIIKILLNA---GAEINSRTGSK---LGISPLMLAAMNG-----HVPAVK-- 1207

Query: 433  SFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGE 492
                      L+  GS  +A      N  L  A   G       L    A+V HR K G 
Sbjct: 1208 ---------LLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGL 1258

Query: 493  TPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEA-ASLTSLADSVHLQ------- 544
            TPL  A   G A +   LL +GA+ N     A P+P     +LT  AD  H +       
Sbjct: 1259 TPLMEAASGGYAEVGRVLLDKGADVN-----APPVPSSRDTALTIAADKGHYKFCELLIH 1313

Query: 545  -------------TPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIP 580
                         TPL +A    H DVV ++++  A+ + A +N +I P
Sbjct: 1314 RGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD-VDAADNRKITP 1361



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 74/335 (22%), Positives = 130/335 (38%), Gaps = 54/335 (16%)

Query: 271 IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLV 330
           +A  L+   A+++ V+  G++ L +  + G       L+  GA +NA T   QET L L 
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512

Query: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
                           +++A+ L++AGA+  +  S   TPL  +   G+  +   LL   
Sbjct: 513 CC-----------GGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLL-AS 557

Query: 391 QLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAAR-------- 442
             ++      G TAL       T + +       DV +  G   +  S   R        
Sbjct: 558 GANVHATTATGDTAL-------TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610

Query: 443 ---------LIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGET 493
                    LI +G++ +       + ++  A   G+ A    L  +GA   HR K G T
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670

Query: 494 PLHTACRHGLANLTAELLQQGANP-NLQTEEALPLPKEAASLTSLADSVHLQTPLH---M 549
            L  A + G  N+ + LL    N  ++ T +   LP  +   + +      + P H   M
Sbjct: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVP-----RVPTHTLAM 725

Query: 550 AIAYNHPDVVS------VILEQKANALHATNNLQI 578
            +    PD  S      ++  QK  +   +++LQ+
Sbjct: 726 VVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQV 760



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 47/180 (26%), Positives = 85/180 (47%), Gaps = 18/180 (10%)

Query: 238  LIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGI 297
            L++M S +  ++   + N + AL LA  +    + + L+  KA+V+   K+G + L +  
Sbjct: 1209 LLDMGSDINAQI---ETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265

Query: 298  QRGDLFAATFLIKNGAFVNAATL-GAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQA 356
              G       L+  GA VNA  +  +++T L + A    K H         +  E L+  
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAA---DKGH--------YKFCELLIHR 1314

Query: 357  GANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ--HITV 414
            GA+ ++++ KG TPL ++   G+  V   L+Q    D++  D+   T L  A +  H+ V
Sbjct: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA-GADVDAADNRKITPLMSAFRKGHVKV 1373



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 9/182 (4%)

Query: 909  TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAA 968
            T L LA   G E +V  L+   AK+    K   T L LAA      +  +LL+ G D  A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 969  VDENGNNA-LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFD 1027
              E   +  L LA   GR   + +LL     + E  N+   +PL +    G  N   I  
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVN---IIK 1172

Query: 1028 LFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSG----ARLGVNNNQGVNIFN 1083
            + L              G + L+LA M G+    + ++  G    A++  N N  + +  
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232

Query: 1084 YQ 1085
            +Q
Sbjct: 1233 FQ 1234



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 41/168 (24%), Positives = 69/168 (41%), Gaps = 13/168 (7%)

Query: 914  AVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENG 973
            A   G    VR LL  G  VNE T+  ++ L LA       +  VLL      A V++ G
Sbjct: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL---AMHANVEDRG 268

Query: 974  NNA----LHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLF 1029
            N      L  A   G L+ +++LL     D  + +  G + L      G  +   +    
Sbjct: 269  NKGDITPLMAASSGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKVL--- 324

Query: 1030 LECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQ 1077
                 G  ++  + +G T L+ A   G+  + R ++  GA +  ++N+
Sbjct: 325  --LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 78/230 (33%), Positives = 116/230 (50%), Gaps = 11/230 (4%)

Query: 769 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPD 828
           + G+TPLHLAA+ G    VQ LL+ G +++ QD   +T +H A    +  II  L+ H  
Sbjct: 40  KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALI-HEG 98

Query: 829 IHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIES 887
             L+ +D+ G T    A     ++SA+ ++K  +GA     NK G   LH+A QNS  +S
Sbjct: 99  CALDRQDKDGNTALHEASWHGFSQSAKLLVK--AGANVLAKNKAGNTALHLACQNSHSQS 156

Query: 888 --VLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALH 945
             VL L    A++ +   D    T LH+A +     I+R LL A   V+E  +   TALH
Sbjct: 157 TRVLLLAGSRADLKNNAGD----TCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALH 212

Query: 946 LAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTE 995
           +AA  +   +  +LLE G D   V+  G   L  A  H     + +LLT+
Sbjct: 213 VAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN-PEVALLLTK 261



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 75/303 (24%), Positives = 119/303 (39%), Gaps = 55/303 (18%)

Query: 657 ETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDAT 716
           E  L  A + Q   VV  I  +GA ++V  + G  PL LA       +   L++ GCD  
Sbjct: 12  ERLLVAAYKGQTENVVQLI-NKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLD 69

Query: 717 CWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLH 776
               G     QT LHRA    N      LI  GC +            + + +DG T LH
Sbjct: 70  VQDDGD----QTALHRATVVGNTEIIAALIHEGCAL------------DRQDKDGNTALH 113

Query: 777 LAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDR 836
            A+  G  ++ + L++ GANV A++  G T +H+A  + H                    
Sbjct: 114 EASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSH-------------------- 153

Query: 837 QGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHA 896
                            +  +L      A+  +N G   LHVA + + +  +  L++   
Sbjct: 154 ---------------SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFC 198

Query: 897 NVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTIC 956
           +V+ + Q     T LH+A     + + + LL AGA    +    QT L  A   + P + 
Sbjct: 199 SVHEKNQAGD--TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256

Query: 957 SVL 959
            +L
Sbjct: 257 LLL 259



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 66/310 (21%)

Query: 520 QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQII 579
           QTE  + L  + A +   A + H +TPLH+A    H  VV ++L+               
Sbjct: 22  QTENVVQLINKGARV---AVTKHGRTPLHLAANKGHLPVVQILLKAGC------------ 66

Query: 580 PDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSAL 639
            D  ++D  DQT L  A   G   I A L+  G A++    DG T LH A     S+SA 
Sbjct: 67  -DLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 125

Query: 640 FLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALAN 699
            L++  A++ +++ + G TAL LA +N        +   G+   + +  G+         
Sbjct: 126 LLVKAGANV-LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGD--------- 175

Query: 700 NLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPG 759
                                       T LH A   N+      L+ + C V+   Q  
Sbjct: 176 ----------------------------TCLHVAARYNHLSIIRLLLTAFCSVHEKNQA- 206

Query: 760 ANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVI 819
                      G T LH+AA+   ++  + LLE GA+    +  G+TP+  A    +  +
Sbjct: 207 -----------GDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEV 255

Query: 820 IQLLVSHPDI 829
             LL   P +
Sbjct: 256 ALLLTKAPQV 265



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 8/216 (3%)

Query: 863  GAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEII 922
            GA   V   GR  LH+A     +  V  L+    +++  VQD    T LH A   G+  I
Sbjct: 33   GARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLD--VQDDGDQTALHRATVVGNTEI 90

Query: 923  VRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVM 982
            +  L+  G  ++   K   TALH A+         +L++ G +  A ++ GN ALHLA  
Sbjct: 91   IAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQ 150

Query: 983  HGRLNNIRVLLTECTVDAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPD 1042
            +    + RVLL   +  A+  N  G + LH+  +Y   N  +I  L L       + + +
Sbjct: 151  NSHSQSTRVLLLAGS-RADLKNNAGDTCLHVAARY---NHLSIIRLLLTAF--CSVHEKN 204

Query: 1043 ADGSTVLLLAYMKGNANLCRAIVRSGARLGVNNNQG 1078
              G T L +A    +  + + ++ +GA   + NN G
Sbjct: 205  QAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 240



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/286 (26%), Positives = 108/286 (37%), Gaps = 57/286 (19%)

Query: 367 GRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDV 426
           GRTPLH++   G+  V   LL+    DL+++D    TAL  A                  
Sbjct: 42  GRTPLHLAANKGHLPVVQILLKAG-CDLDVQDDGDQTALHRAT----------------- 83

Query: 427 PVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNH 486
            VV  T        A LI  G   D  D   GN  L  A+  G   +A  L   GA+V  
Sbjct: 84  -VVGNTEI-----IAALIHEGCALDRQDK-DGNTALHEASWHGFSQSAKLLVKAGANVLA 136

Query: 487 RNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTP 546
           +NK G T LH AC++  +  T  LL  G+  +L+                        T 
Sbjct: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAG-------------------DTC 177

Query: 547 LHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAA 606
           LH+A  YNH  ++ ++L    +                K+    T L +A       +A 
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHE-------------KNQAGDTALHVAAALNHKKVAK 224

Query: 607 QLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSR 652
            LL +GA      + GQT L  A    + + AL L +    +  SR
Sbjct: 225 ILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSR 270



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 67/267 (25%), Positives = 109/267 (40%), Gaps = 57/267 (21%)

Query: 308 LIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKG 367
           LI  GA V     G   TPLHL A   +K H          + + LL+AG + ++QD   
Sbjct: 29  LINKGARVAVTKHG--RTPLHLAA---NKGH--------LPVVQILLKAGCDLDVQDDGD 75

Query: 368 RTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVP 427
           +T LH + + GN  + + L+  +   L+ +D +G+TAL  A  H                
Sbjct: 76  QTALHRATVVGNTEIIAALIH-EGCALDRQDKDGNTALHEASWH---------------- 118

Query: 428 VVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHR 487
                 F ++  A  L++ G++  A + A GN  L  A    +  +   L   G+  + +
Sbjct: 119 -----GFSQS--AKLLVKAGANVLAKNKA-GNTALHLACQNSHSQSTRVLLLAGSRADLK 170

Query: 488 NKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPL 547
           N  G+T LH A R+   ++   LL    + + + +                      T L
Sbjct: 171 NNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAG-------------------DTAL 211

Query: 548 HMAIAYNHPDVVSVILEQKANALHATN 574
           H+A A NH  V  ++LE  A+     N
Sbjct: 212 HVAAALNHKKVAKILLEAGADTTIVNN 238



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 54/247 (21%), Positives = 93/247 (37%), Gaps = 37/247 (14%)

Query: 255 NGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAF 314
           +G   L LA ++    +   L+    D+D+ D    + LH+    G+      LI  G  
Sbjct: 41  HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA 100

Query: 315 VNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVS 374
           ++              AL+ +  H        +Q A+ L++AGAN   ++  G T LH++
Sbjct: 101 LDRQDKDGN------TALHEASWHG------FSQSAKLLVKAGANVLAKNKAGNTALHLA 148

Query: 375 IMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSF 434
               +    +++L       +LK++ G T L +A ++  +S                   
Sbjct: 149 CQNSHSQ-STRVLLLAGSRADLKNNAGDTCLHVAARYNHLS------------------- 188

Query: 435 DENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETP 494
                  RL+     +       G+  L  AA   ++  A  L   GA     N  G+TP
Sbjct: 189 -----IIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTP 243

Query: 495 LHTACRH 501
           L TA  H
Sbjct: 244 LETARYH 250



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 47/160 (29%), Positives = 65/160 (40%), Gaps = 13/160 (8%)

Query: 249 LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL 308
           L+  D     AL  A       I   L+     +D  DK G + LH+    G   +A  L
Sbjct: 68  LDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLL 127

Query: 309 IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR 368
           +K GA V A    A  T LHL        HS        Q    LL AG+  +++++ G 
Sbjct: 128 VKAGANVLAKN-KAGNTALHLAC---QNSHS--------QSTRVLLLAGSRADLKNNAGD 175

Query: 369 TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA 408
           T LHV+    N     +LL      +  K+  G TAL +A
Sbjct: 176 TCLHVAARY-NHLSIIRLLLTAFCSVHEKNQAGDTALHVA 214


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.132    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,117,331
Number of Sequences: 37866
Number of extensions: 1868669
Number of successful extensions: 15694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 402
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 5499
Number of HSP's gapped (non-prelim): 4055
length of query: 1170
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1057
effective length of database: 13,968,660
effective search space: 14764873620
effective search space used: 14764873620
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.