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Search of human proteins with 110624785
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110624785 NACHT, leucine rich repeat and PYD containing 13
[Homo sapiens]
(1043 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 2129 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 636 0.0
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 525 e-149
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 519 e-147
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 496 e-140
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 494 e-139
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 490 e-138
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 485 e-137
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 485 e-137
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 468 e-131
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 465 e-131
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 461 e-129
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 459 e-129
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 446 e-125
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 443 e-124
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 418 e-116
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 409 e-114
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 337 5e-92
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 337 5e-92
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 337 5e-92
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 336 8e-92
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 336 8e-92
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 228 2e-59
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 183 8e-46
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 175 2e-43
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 175 2e-43
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 175 2e-43
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 175 2e-43
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 175 2e-43
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 175 2e-43
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 2129 bits (5517), Expect = 0.0
Identities = 1043/1043 (100%), Positives = 1043/1043 (100%)
Query: 1 MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANL 60
MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANL
Sbjct: 1 MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANL 60
Query: 61 RAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQE 120
RAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQE
Sbjct: 61 RAADPLNLSFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQE 120
Query: 121 DLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKY 180
DLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKY
Sbjct: 121 DLEMLEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKY 180
Query: 181 RENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVG 240
RENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVG
Sbjct: 181 RENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVG 240
Query: 241 KTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFM 300
KTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFM
Sbjct: 241 KTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFM 300
Query: 301 SQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLL 360
SQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLL
Sbjct: 301 SQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLL 360
Query: 361 ITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFH 420
ITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFH
Sbjct: 361 ITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFH 420
Query: 421 SCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQW 480
SCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQW
Sbjct: 421 SCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQW 480
Query: 481 RALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQ 540
RALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQ
Sbjct: 481 RALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQ 540
Query: 541 EFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIAREL 600
EFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIAREL
Sbjct: 541 EFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIAREL 600
Query: 601 EDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFE 660
EDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFE
Sbjct: 601 EDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFE 660
Query: 661 VDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICS 720
VDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICS
Sbjct: 661 VDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICS 720
Query: 721 TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG 780
TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG
Sbjct: 721 TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG 780
Query: 781 NSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
NSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV
Sbjct: 781 NSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
Query: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHL 900
TRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHL
Sbjct: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHL 900
Query: 901 NLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLG 960
NLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLG
Sbjct: 901 NLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLG 960
Query: 961 ENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNEL 1020
ENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNEL
Sbjct: 961 ENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNEL 1020
Query: 1021 DTDGVKMLCKALKKSTCRLQKLG 1043
DTDGVKMLCKALKKSTCRLQKLG
Sbjct: 1021 DTDGVKMLCKALKKSTCRLQKLG 1043
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 636 bits (1641), Expect = 0.0
Identities = 395/1038 (38%), Positives = 569/1038 (54%), Gaps = 69/1038 (6%)
Query: 16 GLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEH 75
GLL YL L++ +L FKL L+ + PW ++ A +L+ L+ ++
Sbjct: 14 GLLLYLEELNKEELNTFKLFLKETM--------EPEHGLTPWNEVKKARREDLANLMKKY 65
Query: 76 FPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+P +AW V L IF MNL LCE+ + E+ + QT
Sbjct: 66 YPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTI----------------------- 102
Query: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNI 195
P+ + E +E+ V G + YR +K + TWD
Sbjct: 103 ---GPDDAKAGETQEDQEAVLGDGTE------------------YRNRIKEKFCITWDKK 141
Query: 196 SWP-KDHVYIRNTSKDEHEELQRLLDPN-RTRAQAQTIVLVGRAGVGKTTLAMQAMLHWA 253
S K + ++ + + L+ L D + +T AQ Q +VL G AGVGKTTL +AML WA
Sbjct: 142 SLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWA 201
Query: 254 NGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGF 313
G L+QQRF YVFYL+ +I +KE +FA+LIS DWP + PIEE M QP LLFIID F
Sbjct: 202 EGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSF 261
Query: 314 EEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
+E+ + E + C DW QE PV+ ++ SLL+K ++P A+LL+T + + LK
Sbjct: 262 DELNFAFEEPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQ 317
Query: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
L N +V++ G + D Y + F+D K+ L+ NE LF C P+VCW C+
Sbjct: 318 LLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACT 377
Query: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQ--WRALCSLAIEGL 491
CLKQ + D+ QTTT+L+ + S+LF+ VD S P Q R LC +A +G+
Sbjct: 378 CLKQQMEKGGDVTLTCQTTTALFTCYISSLFTP--VDGGSPSLPNQAQLRRLCQVAAKGI 435
Query: 492 WSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLE 551
W+M + F +E+ GL + S + NI+QK + C FTHL QEFFAAM ++L+
Sbjct: 436 WTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLK 495
Query: 552 EPREFPPHSTKP-QEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISP 610
E S +P +++K LLQ K+ + T + F FGLLN++ ++LE T +CK+S
Sbjct: 496 GSWEAGNPSCQPFEDLKSLLQSTSY-KDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
Query: 611 RVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEE 670
++ +LL+ E LG ++ + Q L LFHCL+E+Q++ F + + +V +NI E
Sbjct: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
Query: 671 LQASSFCLKHCKRLNKLRLSVSSHILERDLEI-LETSKFDSR--MHAWNSICSTLVTNEN 727
L SSFCLKHC+ L +RLSV+ ++ L+ L T+ +D H W +CS L TNE+
Sbjct: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
Query: 728 LHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHL 787
L ELDL +S L S++ L L++P CK+QKL K +T QD+ +L N L HL
Sbjct: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
Query: 788 NFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLG 846
+ + +G V + +AL+H C L+ L LE CNL+ C +++ L Q + L L
Sbjct: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
Query: 847 FNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNS 906
N L DDG++LLC AL HPKC LERL L C L C++LS AL+ N+ LTHL L+ N
Sbjct: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
Query: 907 LRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQD 966
L D GVK + +AL L+SL L C FT L+ +L HN ++ LDLG N LQD
Sbjct: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
Query: 967 DGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGV 1025
+GVKLLC+ + P L L L C LT ACC L SV+ ++ +L +L+L N+L DGV
Sbjct: 915 NGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGV 974
Query: 1026 KMLCKALKKSTCRLQKLG 1043
K+LC AL+ C +Q+LG
Sbjct: 975 KILCDALRYPNCNIQRLG 992
Score = 128 bits (321), Expect = 3e-29
Identities = 103/322 (31%), Positives = 163/322 (50%), Gaps = 29/322 (9%)
Query: 625 KAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCK-R 683
K ++ L+ L +F CL+ S ++ ++ + N L D+ +Q L+H K
Sbjct: 759 KLQTLRLESCNLTVFCCLNISNALIRSQSLI--FLNLSTNNLLDDGVQLLCEALRHPKCY 816
Query: 684 LNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSV 743
L +L L S + E E L + L++N+ L L L+++ L V
Sbjct: 817 LERLSLE-SCGLTEAGCEYLSLA---------------LISNKRLTHLCLADNVLGDGGV 860
Query: 744 KGLCLALKNPRCKVQKLTCK-----SVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMT- 797
K + AL++ +C ++ L + S++ E++ L+ N LTHL+ SN L
Sbjct: 861 KLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL----HNKSLTHLDLGSNWLQDNG 916
Query: 798 VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKL 857
V L+ RH +CNL+ L L C L+ A C DLA + + ++ L LG N LQDDG+K+
Sbjct: 917 VKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKI 976
Query: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
LC AL +P C ++RL L +C L + C+ LS AL+ N+ L +NL++N+L EG+ L +
Sbjct: 977 LCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYK 1036
Query: 918 ALGRPDGNLQSLNLSGCSFTRE 939
L P LQ L L +F E
Sbjct: 1037 VLKSPKCKLQVLGLCKEAFDEE 1058
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 525 bits (1353), Expect = e-149
Identities = 318/877 (36%), Positives = 483/877 (55%), Gaps = 12/877 (1%)
Query: 170 MLEEADHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEH-EELQRLLDPNRTRAQA 228
M E + + Y+ + K + W + S + H+Y K E + L RL P Q
Sbjct: 89 MRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQP 148
Query: 229 QTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLD 288
+T+++ G G+GKTTL M+ M+ W++ +F+ RF Y FY C ++R + T+ A+LIS +
Sbjct: 149 RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISRE 208
Query: 289 WPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSL 348
WPD API E +SQPE+LLF+ID FEE+ + D C D ++ PV +L SL
Sbjct: 209 WPDPAAPITEIVSQPERLLFVIDSFEEL----QGGLNEPDSDLCGDLMEKRPVQVLLSSL 264
Query: 349 LKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKI 408
L+K+++P A+LLI IK ++L+ + Q GF D VYF F D +
Sbjct: 265 LRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEA 324
Query: 409 LQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAE 468
+R++E LF C P++CW +C+ LKQ + DL Q+TTS+Y+ F NLF+
Sbjct: 325 FNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEG 384
Query: 469 VDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDC 528
+ Q +ALCSLA EG+W+ F F ++D G+ I +L IL K +
Sbjct: 385 AEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGER 444
Query: 529 GGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFF 588
F H+ QEF AA+ ++L+ + PH ++L+ + + A+W + F
Sbjct: 445 ESSYVFLHVCIQEFCAALFYLLKSHLDH-PHPAVRCVQELLVANFEKARRAHWIFLGCFL 503
Query: 589 FGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEE 648
GLLNK +L+ ++S + +++ + + LG+ + Q L +F+CL E Q+
Sbjct: 504 TGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDP 563
Query: 649 DFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKF 708
F K+ + + E + +I+++ +L S++CLK+C L KL SV ++ +++ E TS
Sbjct: 564 AFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKEDEHSSTS-- 620
Query: 709 DSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPE 768
D + W+ ICS L T+ +L EL + +S L S+ C L++P C++QKL +V+
Sbjct: 621 DYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFS 680
Query: 769 WVLQDLIIALQGNSKLTHLNFSSNKLGM-TVPLILKALRHSACNLKYLCLEKCNLSAASC 827
L L L +L+F+ KL + + AL + A N+K L L C+LS C
Sbjct: 681 GQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDC 740
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ LA LT+ + +T L + N+L D G+ LLC AL P L L L FC L+ C+++
Sbjct: 741 EVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANA 947
S+ LL+N+S+ +L+LS N L+DEG+K LCEAL PD L SL L C T GC +LA+A
Sbjct: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
Query: 948 LSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSS 1006
L N N+KIL +G N++ D GV+LLC AL L LGL +C LT+ CC+ L SVL+
Sbjct: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTC 919
Query: 1007 SKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
SK+L LNL N LD GV +LC+AL+ C LQ LG
Sbjct: 920 SKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLG 956
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 7/134 (5%)
Query: 16 GLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEH 75
GL+ YL L + + +FK L+ L Q +IPW ++ A L+ LL +H
Sbjct: 10 GLMWYLEELKKEEFRKFKEHLKQMTL-------QLELKQIPWTEVKKASREELANLLIKH 62
Query: 76 FPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+ + QAW + L IFQ M+ LC KV E +T + + + +
Sbjct: 63 YEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLY 122
Query: 136 GCQDPNQEELDELE 149
++ QEE D L+
Sbjct: 123 FEEEVKQEECDHLD 136
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 519 bits (1337), Expect = e-147
Identities = 348/1057 (32%), Positives = 541/1057 (51%), Gaps = 68/1057 (6%)
Query: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
L YL L+ +L++FKL L +A + +IPW ++ A PL ++ LL HF
Sbjct: 13 LSTYLEELEAVELKKFKLYLG--------TATELGEGKIPWGSMEKAGPLEMAQLLITHF 64
Query: 77 PKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQ---EDLEMLEAAAGNMQ 133
+AW++ L F+ +N L E R + ++ V+ P+ + +LE + +
Sbjct: 65 GPEEAWRLALSTFERINRKDLWE--RGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPR 122
Query: 134 TQGCQDPNQEELDELEE-----ETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL 188
+DP + D + E N + C + + +L +H + ++ +L
Sbjct: 123 ----KDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ--VQQQL 176
Query: 189 LETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQA-QTIVLVGRAGVGKTTLAMQ 247
L+T + H + +++ L +P+ R + +T+V+ G AG+GK+ LA +
Sbjct: 177 LDTGRGHARTVGH-------QASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHK 229
Query: 248 AMLHWANGVLFQQRFSYVFYLSCHKIRYMK-ETTFAELISLDWPDFDAPIEEFMSQPEKL 306
ML WA+G LFQ RF Y+FY++C ++ E + +LI WP+ AP++E + PE+L
Sbjct: 230 VMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERL 289
Query: 307 LFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTW 366
LFIIDGF+E+ S + G C W ++ P +L+SL++K+L+P +LLIT +
Sbjct: 290 LFIIDGFDELKPSFHDPQ----GPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPT 345
Query: 367 FVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPM 426
+ L L +P V+I GF+ + + YF ++F ++ + ++ +R NE LF C P+
Sbjct: 346 ALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPL 405
Query: 427 VCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSL 486
VCW VC+CL+Q L+ ++TTT++Y + +L P Q R LCSL
Sbjct: 406 VCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQ-RGLCSL 464
Query: 487 AIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAM 546
A +GLW+ F ++D GL+ + + NI QK +C +F HLSFQEFFAAM
Sbjct: 465 AADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAM 524
Query: 547 SFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHC 606
++L+E + Q++ LL + ++ F FGLLN+ LE +L
Sbjct: 525 YYILDEGEG---GAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCW 581
Query: 607 KISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDL--N 664
K+SP + +LL+W + +++ ++LQ L F CL+E QEE+F ++ L F+V + N
Sbjct: 582 KVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSH-FQVIVVSN 640
Query: 665 ILEDEELQASSFCLKHCKRLNKLRL---------------SVSSHILERDLEILETSKFD 709
I E SSFCLK C+ L L S +H L +++ +
Sbjct: 641 IASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTL-----LVQLPERT 695
Query: 710 SRMHAWNS-ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-P 767
+ A++ + + L TN NL EL L + L + VK LC L++P CK+Q L K
Sbjct: 696 VLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRIS 755
Query: 768 EWVLQDLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAAS 826
+DL AL N LT ++ S N +G + L+ + LRH C L+ + L KC L + +
Sbjct: 756 SSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGA 815
Query: 827 CQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKH 886
CQ++A L + H+ L L N L+D G++LLC L HP C L L L C+L A AC
Sbjct: 816 CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 875
Query: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
L+ L N+SL L+LS N L D GV LCE L P LQ+L L C C L+
Sbjct: 876 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSV 935
Query: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
L NHN++ LDL NDL D G+ LL E L+ P L L L C LT C++L+ L
Sbjct: 936 VLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLG 995
Query: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+++L +L L N L GV++LCK L C+L+ L
Sbjct: 996 INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 1032
Score = 131 bits (330), Expect = 3e-30
Identities = 87/248 (35%), Positives = 130/248 (52%), Gaps = 2/248 (0%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L++++ K A + S L TN +L ELDL+ + L ++ LC L++P C+++
Sbjct: 801 LQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRT 860
Query: 760 LTCKSVT-PEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCL 817
L K +L L N L L+ S N+LG + V L+ + LRH C L+ L L
Sbjct: 861 LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
Query: 818 EKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFC 877
C L +A+C+ L++ L + ++ L L FN L D G+ LL L HP C L++L L C
Sbjct: 921 GICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSC 980
Query: 878 QLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFT 937
L A AC++L L N++LT L L+ N+L D GV+ LC+ L P L+ L L G
Sbjct: 981 GLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLN 1040
Query: 938 REGCGELA 945
+ LA
Sbjct: 1041 KMTHSRLA 1048
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 496 bits (1277), Expect = e-140
Identities = 336/1036 (32%), Positives = 517/1036 (49%), Gaps = 48/1036 (4%)
Query: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHFPKGQ 80
L L Q +L +FK + L +IP + AD L +L H
Sbjct: 15 LEQLSQDELSKFKYLITTFSLAH-------ELQKIPHKEVDKADGKQLVEILTTHCDSYW 67
Query: 81 AWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDP 140
L +F+ M+ L E+ + E++E + L + + +
Sbjct: 68 VEMASLQVFEKMHRMDLSERAKDEVRE-AALKSFNKRKPLSLGITRKERPPLDVDEMLER 126
Query: 141 NQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKD 200
+ E E GNV G + ++P+ D+R +Y +K + E W SWP D
Sbjct: 127 FKTEAQAFTETKGNVICLGKEVFKGKKPDK----DNRCRYI--LKTKFREMWK--SWPGD 178
Query: 201 HVYIRNTSKDEHEELQRLLDPNRTRAQ----AQTIVLVGRAGVGKTTLAMQAMLHWANGV 256
++ + E + L+ + R + T+VL G AG+GKTTLA + ML WA
Sbjct: 179 SKEVQVMA----ERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDN 234
Query: 257 LFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEI 316
L +F Y FYLSC ++ + +FAEL+ DWP+ I ++Q K+LF+IDGF+E+
Sbjct: 235 LIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDEL 293
Query: 317 IISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLV 376
+ ++D C DW ++ PV +L SLL + ++P A LL+T + +RDL+
Sbjct: 294 --GAAPGALIED--ICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAE 349
Query: 377 NPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLK 436
P ++++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 350 EPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLK 409
Query: 437 QPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNF 496
+ D T T L+ F + F G R L LA +GLW+
Sbjct: 410 LQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQTS 463
Query: 497 TFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLE--EPR 554
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + LE E
Sbjct: 464 VLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEE 523
Query: 555 EFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVME 614
+ H+ +++ LL V + + FGL N+ A+ELE T C++SP + +
Sbjct: 524 DRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQ 583
Query: 615 ELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQAS 674
ELL+ ++ S + L CL+ESQEE+ K+++ + E+ L+ L ++ S
Sbjct: 584 ELLRC--DISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLH-LNAVDVVPS 640
Query: 675 SFCLKHCKRLNKLRLSVSSHIL-------ERDLEILETSKFDSRMHAWNSICSTLVTNEN 727
SFC+KHC+ L K+ L V L E D E+ + + W +CS +N++
Sbjct: 641 SFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKD 700
Query: 728 LHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHL 787
L L +++S L AS V+ LC + + C +Q++ K+++P ++L +AL+G+ +T+L
Sbjct: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYL 760
Query: 788 NFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGF 847
N P + + LRH CNL+YL L C+ + DL+L L Q +T + L
Sbjct: 761 TLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSD 820
Query: 848 NRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSL 907
N L D+G KLL L HPKC L+RL L C L CK L+ L+ +R LTHL L+KN +
Sbjct: 821 NELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPI 880
Query: 908 RDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDD 967
+ GVKFLCE L P+ LQ+L L C T +GC +L L ++ LDLG N +
Sbjct: 881 GNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVK 940
Query: 968 GVKLLCEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVK 1026
G+K LCEAL KP L L L C++ C+ L S LS ++SLV L+L N L + GVK
Sbjct: 941 GMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVK 1000
Query: 1027 MLCKALKKSTCRLQKL 1042
ML + L S+ L+ L
Sbjct: 1001 MLFETLTCSSGTLRTL 1016
Score = 119 bits (297), Expect = 2e-26
Identities = 80/245 (32%), Positives = 122/245 (49%), Gaps = 2/245 (0%)
Query: 697 ERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCK 756
E +L L + W + L N++L ++LS+++L K L L++P+C
Sbjct: 782 ECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCF 841
Query: 757 VQKLTCKSV-TPEWVLQDLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKY 814
+Q+L+ ++ E +DL L + +LTHL + N +G T V + + LR+ C L+
Sbjct: 842 LQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQT 901
Query: 815 LCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874
L L C++++ C DL L + L LG N + G+K LC AL P C L L L
Sbjct: 902 LVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWL 961
Query: 875 WFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGC 934
W C + +C+ L AL N+SL L+L +N L GVK L E L G L++L L
Sbjct: 962 WGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKID 1021
Query: 935 SFTRE 939
F E
Sbjct: 1022 DFNDE 1026
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 494 bits (1271), Expect = e-139
Identities = 304/868 (35%), Positives = 466/868 (53%), Gaps = 22/868 (2%)
Query: 180 YRENMKAELLETWDNISW--PKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRA 237
YR++MK W+ + +H Y + T K+E++EL D A+ T+VL G
Sbjct: 99 YRKHMKETFQLIWEKETCLHVPEHFY-KETMKNEYKELN---DAYTAAARRHTVVLEGPD 154
Query: 238 GVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIE 297
G+GKTTL + ML WA G L++ RF++VF+L+ ++ + ET+ EL+S DWP+ IE
Sbjct: 155 GIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIE 214
Query: 298 EFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLA 357
+ SQPE++LFI+DGFE++ + L D DW Q P+ IL SLL+K+++P +
Sbjct: 215 DIFSQPERILFIMDGFEQLKFNLQLKADLSD-----DWRQRQPMPIILSSLLQKKMLPES 269
Query: 358 TLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNET 417
+LLI + ++ L +P +++ GF+ + + YF F + S+ K+ +R N
Sbjct: 270 SLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGP 329
Query: 418 LFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWP 477
LF C P CW VC+C+KQ R DL+ +Q TT LYA F + +F
Sbjct: 330 LFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNR 389
Query: 478 GQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHL 537
+ ++LC+LA EG+W+ F F+ D GL +LQ+ DC F HL
Sbjct: 390 ARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHL 446
Query: 538 SFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIA 597
QEF AAM ++L+ P++ P + + L++ ++ + T V +F FG+ + I
Sbjct: 447 CIQEFCAAMFYLLKRPKDDPNPAIG--SITQLVRASVVQPQTLLTQVGIFMFGISTEEIV 504
Query: 598 RELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGR 657
LE + +S + +E+ + E L + E+ LF L E+QE++F K++
Sbjct: 505 SMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNF 564
Query: 658 IFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNS 717
EV + I E L +SFCLKHC+ L LR+ V + I D + S ++ ++ W
Sbjct: 565 FEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVEN-IFPDDSGCI--SDYNEKLVYWRE 621
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
+CS +TN+N LD+ N+ L S+ LC AL P CK++KL SV +L A
Sbjct: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHD-SELFKA 680
Query: 778 LQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
+ N L L+ L + + + + L+H C ++ L L KC++S+ C+D+A L
Sbjct: 681 VLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLAC 740
Query: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
+ L L N L+D+G+ LLC AL H CALERL L +C L + +C +S+ LL ++S
Sbjct: 741 NSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKS 800
Query: 897 LTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKI 956
L+ L+L N+L D GV LC AL P +++ L L GC T + C ++A L N +K
Sbjct: 801 LSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKT 860
Query: 957 LDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNL 1015
L LG N++ D GV+ LC AL+ PH L LGL C +T ACC + + L + K+L +LNL
Sbjct: 861 LKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNL 920
Query: 1016 LGNELDTDGVKMLCKALKKSTCRLQKLG 1043
LD D V +LC+AL C LQ LG
Sbjct: 921 DWIALDADAVVVLCEALSHPDCALQMLG 948
Score = 117 bits (294), Expect = 4e-26
Identities = 94/284 (33%), Positives = 129/284 (45%), Gaps = 12/284 (4%)
Query: 668 DEELQASSFCLKHCKRLNKLRLSVSS----HILER------DLEILETSKFDSRMHAWNS 717
D EL + H K L+ S+S H+ E +E L K D
Sbjct: 674 DSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCED 733
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
I S L N L L L + L + LC ALK+ C +++L V D I
Sbjct: 734 IASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISE 793
Query: 778 LQGNSK-LTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLT 835
+ SK L+ L+ SN L V + AL+H C+++ L L C L++ SC+D+A L
Sbjct: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
Query: 836 SIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNR 895
+ L LG N + D G++ LCAAL HP C LE L L C + C ++ AL+ +
Sbjct: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
Query: 896 SLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+L LNL +L + V LCEAL PD LQ L L F E
Sbjct: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEE 957
Score = 55.5 bits (132), Expect = 3e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 7/94 (7%)
Query: 16 GLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEH 75
GLL YL L + + +FK L+ Q L F P IPWA L+ A +++ LLD+H
Sbjct: 10 GLLWYLKELRKEEFWKFKELLK-QPLEKFELKP------IPWAELKKASKEDVAKLLDKH 62
Query: 76 FPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENV 109
+P QAW+V L +F +N L K + EM+ +
Sbjct: 63 YPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKL 96
Score = 44.7 bits (104), Expect = 5e-04
Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKL---TCKSVTPEWVLQDL 774
I + L+ N L L L ++++ + V+ LC AL++P CK++ L TC D+
Sbjct: 848 IAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA--CCDDI 905
Query: 775 IIALQGNSKLTHLNFSSNKLGMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALF 833
AL L LN L ++L +AL H C L+ L L K + + L
Sbjct: 906 AAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSV 965
Query: 834 LTSIQHVT 841
I H+T
Sbjct: 966 EEKIPHLT 973
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 490 bits (1261), Expect = e-138
Identities = 344/1065 (32%), Positives = 535/1065 (50%), Gaps = 59/1065 (5%)
Query: 13 TNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL 72
++ GL L LD+ + + FK L+ + + + IP + A+ L+ LL
Sbjct: 61 SSYGLQWCLYELDKEEFQTFKELLKKK-------SSESTTCSIPQFEIENANVECLALLL 113
Query: 73 DEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQ-----TQELQDPTQEDLEMLEA 127
E++ AW + IF+ MNL +L EK R +MK + T Q P++E + +
Sbjct: 114 HEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQ 173
Query: 128 AAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAE 187
A + QE +E+E A + QE + +E+ E +
Sbjct: 174 AVQQDSATAAETKEQEISQAMEQEG----ATAAETEEQEISQAMEQEGATAAETEE-QGH 228
Query: 188 LLETWDNISWPKDHVYIR------------NTSKD--EHEELQRLLDPNRTRAQAQTIVL 233
+TWD K HV + NT+ D E + L D +R + +T+VL
Sbjct: 229 GGDTWDY----KSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVL 284
Query: 234 VGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFD 293
G++G+GK+ LA + +L WA G L+Q FSYVF+L +++ KE++ E IS +WPD
Sbjct: 285 HGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQ 344
Query: 294 APIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKEL 353
AP+ E MS+PE+LLFIIDGF+++ S +D C DW ++ P ++ SLL+K L
Sbjct: 345 APVTEIMSRPERLLFIIDGFDDL-----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVL 399
Query: 354 VPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLR 413
+P + L++T++ LK+ +V+P ++ + G +G+ + + + L+ +
Sbjct: 400 LPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIM 459
Query: 414 KNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLAD 473
N L C P V +C L+ V + QT T L+A F + + V
Sbjct: 460 NNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRC 519
Query: 474 DSWPGQ--WRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGC 531
+ + + C +A+EG+W+ F+ +D ++GL + +L+ NIL + C
Sbjct: 520 LNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEY 579
Query: 532 TTFTHLSFQEFFAAMSFVLE----EPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLF 587
TF HLS Q+F AA+ +VLE EP P + K + M L+ + W + F
Sbjct: 580 YTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKR-SMELKQAGFHIHSLW--MKRF 636
Query: 588 FFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQE 647
FGL+++++ R LE L C + V ++LL W LG+ +A+ L FHCL E+Q+
Sbjct: 637 LFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQD 696
Query: 648 EDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERD-----LEI 702
++F + L EV L I ++ +L ASSFCL+HC L K+R+ V I RD +
Sbjct: 697 KEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKG-IFPRDESAEACPV 755
Query: 703 LETSKFDSRM--HAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKL 760
+ D + W CS L T+ +L +LDL +S L ++K LC L++P CK+Q L
Sbjct: 756 VPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTL 815
Query: 761 TCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEK 819
++ +Q L + N L LN L V + +AL+H C L+ L L+
Sbjct: 816 MFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDC 875
Query: 820 CNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQL 879
C L+ A ++ LT+ + L L N++ D G+ L AL +CAL++L L C +
Sbjct: 876 CGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGI 935
Query: 880 AAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
A C+ L+ AL+ NRSLTHL LS NSL +EGV LC ++ P +LQ L L+ C
Sbjct: 936 TATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTA 995
Query: 940 GCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQ 998
GCG LA AL N + L L N ++D+GVKLLCE ++ P L L L KC+LT ACC+
Sbjct: 996 GCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCE 1055
Query: 999 HLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
L V+S S+ L +L+L N L GV LC+ LK+ L +LG
Sbjct: 1056 SLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100
Score = 129 bits (324), Expect = 1e-29
Identities = 82/217 (37%), Positives = 117/217 (53%), Gaps = 2/217 (0%)
Query: 717 SICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWV-LQDLI 775
S+ S LV+N +L L LSN+ L V LC +++ P C +Q+L + L
Sbjct: 942 SLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLA 1001
Query: 776 IALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+AL GNS LTHL+ S N + V L+ + +R +C+L+ L L KC+L+AA C+ L+ +
Sbjct: 1002 LALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVI 1061
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ +H+ L L N L D G+ LC L L RL L C L + C+ LS AL N
Sbjct: 1062 SRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCN 1121
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
R LT LNL +N+ +G+ LC A P NLQ + L
Sbjct: 1122 RHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
Score = 60.5 bits (145), Expect = 8e-09
Identities = 49/173 (28%), Positives = 77/173 (44%), Gaps = 2/173 (1%)
Query: 722 LVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTC-KSVTPEWVLQDLIIALQG 780
L+ N L L LS + + + VK LC ++ P C +Q L K + L +
Sbjct: 1004 LMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISR 1063
Query: 781 NSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQH 839
+ L L+ + N LG V + + L+ L L L+ C L++ C+ L+L L+ +H
Sbjct: 1064 SRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRH 1123
Query: 840 VTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
+T L L N G+ LC+A P L+ + LW Q K L + L
Sbjct: 1124 LTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQL 1176
Score = 31.2 bits (69), Expect = 5.3
Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 3/95 (3%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L+ LE K S+ + + +L LDL+++ L V LC LK + +
Sbjct: 1039 LQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLAR 1098
Query: 760 LTCKS--VTPEWVLQDLIIALQGNSKLTHLNFSSN 792
L K+ +T + + L +AL N LT LN N
Sbjct: 1099 LGLKACGLTSD-CCEALSLALSCNRHLTSLNLVQN 1132
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 485 bits (1249), Expect = e-137
Identities = 330/1043 (31%), Positives = 524/1043 (50%), Gaps = 115/1043 (11%)
Query: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
L YL L+ L++FK+ LE PQ +P AD ++L+ L+ +
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 77 PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+ +AW + + IF +N L EK R E K + +PT
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
Query: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188
CQ+ D +EEE G + + D+R+KYR+ +++
Sbjct: 108 -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
Query: 189 LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225
+++S K + +R + S+ E E+ ++ L DP+
Sbjct: 156 ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
Query: 226 AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284
++ T+V G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++ + + + +L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
Query: 285 ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342
I PD + PI + + +P ++LF++DGF+E+ + D+ G CTDW +
Sbjct: 276 IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
Query: 343 KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402
+L SL++K+L+P A+LLIT + + L+ L +P V+I GF+ + YF ++F D
Sbjct: 330 ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
Query: 403 SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462
++ +++NE LF C P+VCW VC+ LKQ L ++TTT++Y +F S+
Sbjct: 390 AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
Query: 463 LFS----TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518
L + E L W LCSLA +G+W+ F + D GL+ + +
Sbjct: 450 LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
Query: 519 FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572
N+ QK DC +F H++FQEFFAAM ++LEE +E P K +++ +LL++
Sbjct: 505 MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
Query: 573 VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632
++ Y VV F FGL+N+ LE L CKIS ++ ELLKW E KA+ +Q
Sbjct: 565 YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
Query: 633 FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692
L LF+CL+E QEEDF ++ + ++++N+ + SSFC+++C R+ L L
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
Query: 693 SHILERDLE-------------ILETSKFDS------RMHAWNSIC----STLVTNENLH 729
++ + + E +L +S + H +S C S L T+++L
Sbjct: 685 HNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLT 744
Query: 730 ELDLSNSKLHASSVKGLCLALKNPRCKVQKLTC-KSVTPEWVLQDLIIALQGNSKLTHLN 788
ELDLS++ L ++ LC L++P C +++L + D+ + L N KL L+
Sbjct: 745 ELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELD 804
Query: 789 FSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGF 847
S N LG + L+ L+H CNLK L L C L++A CQDLA L++ +TRL +G
Sbjct: 805 LSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGE 864
Query: 848 NRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSL 907
N L D G+ +LC +P+C L++L L L + C LS L N++LTHL L N+L
Sbjct: 865 NALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTL 924
Query: 908 RDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDD 967
D+G+K LCE L PD LQ L L C+ T C +L+ L+ + +++ L LG NDL D
Sbjct: 925 GDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDL 984
Query: 968 GVKLLCEALKPHRA-LHTLGLAK 989
GV + CE LK L LGL++
Sbjct: 985 GVMMFCEVLKQQSCLLQNLGLSE 1007
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 11/102 (10%)
Query: 952 HNVKILDLG--------ENDLQDDGVKL---LCEALKPHRALHTLGLAKCNLTTACCQHL 1000
H V+ L LG E + + +G L C A + GL +LT++ C+ L
Sbjct: 674 HRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGL 733
Query: 1001 FSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
FSVLS+S+SL L+L N L G+++LC+ L+ C +++L
Sbjct: 734 FSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRL 775
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 485 bits (1249), Expect = e-137
Identities = 330/1043 (31%), Positives = 524/1043 (50%), Gaps = 115/1043 (11%)
Query: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
L YL L+ L++FK+ LE PQ +P AD ++L+ L+ +
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 77 PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+ +AW + + IF +N L EK R E K + +PT
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
Query: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188
CQ+ D +EEE G + + D+R+KYR+ +++
Sbjct: 108 -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
Query: 189 LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225
+++S K + +R + S+ E E+ ++ L DP+
Sbjct: 156 ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
Query: 226 AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284
++ T+V G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++ + + + +L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
Query: 285 ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342
I PD + PI + + +P ++LF++DGF+E+ + D+ G CTDW +
Sbjct: 276 IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
Query: 343 KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402
+L SL++K+L+P A+LLIT + + L+ L +P V+I GF+ + YF ++F D
Sbjct: 330 ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
Query: 403 SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462
++ +++NE LF C P+VCW VC+ LKQ L ++TTT++Y +F S+
Sbjct: 390 AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
Query: 463 LFS----TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518
L + E L W LCSLA +G+W+ F + D GL+ + +
Sbjct: 450 LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
Query: 519 FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572
N+ QK DC +F H++FQEFFAAM ++LEE +E P K +++ +LL++
Sbjct: 505 MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
Query: 573 VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632
++ Y VV F FGL+N+ LE L CKIS ++ ELLKW E KA+ +Q
Sbjct: 565 YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
Query: 633 FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692
L LF+CL+E QEEDF ++ + ++++N+ + SSFC+++C R+ L L
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
Query: 693 SHILERDLE-------------ILETSKFDS------RMHAWNSIC----STLVTNENLH 729
++ + + E +L +S + H +S C S L T+++L
Sbjct: 685 HNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLT 744
Query: 730 ELDLSNSKLHASSVKGLCLALKNPRCKVQKLTC-KSVTPEWVLQDLIIALQGNSKLTHLN 788
ELDLS++ L ++ LC L++P C +++L + D+ + L N KL L+
Sbjct: 745 ELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELD 804
Query: 789 FSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGF 847
S N LG + L+ L+H CNLK L L C L++A CQDLA L++ +TRL +G
Sbjct: 805 LSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGE 864
Query: 848 NRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSL 907
N L D G+ +LC +P+C L++L L L + C LS L N++LTHL L N+L
Sbjct: 865 NALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTL 924
Query: 908 RDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDD 967
D+G+K LCE L PD LQ L L C+ T C +L+ L+ + +++ L LG NDL D
Sbjct: 925 GDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDL 984
Query: 968 GVKLLCEALKPHRA-LHTLGLAK 989
GV + CE LK L LGL++
Sbjct: 985 GVMMFCEVLKQQSCLLQNLGLSE 1007
Score = 52.8 bits (125), Expect = 2e-06
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 11/102 (10%)
Query: 952 HNVKILDLG--------ENDLQDDGVKL---LCEALKPHRALHTLGLAKCNLTTACCQHL 1000
H V+ L LG E + + +G L C A + GL +LT++ C+ L
Sbjct: 674 HRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGL 733
Query: 1001 FSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
FSVLS+S+SL L+L N L G+++LC+ L+ C +++L
Sbjct: 734 FSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRL 775
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 468 bits (1205), Expect = e-131
Identities = 336/1045 (32%), Positives = 508/1045 (48%), Gaps = 88/1045 (8%)
Query: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAP-QGHFPRIPWANLRAADPLNLSFLLDEHFPKG 79
L L++ +L+ FK L W+ P + + PW+ + AD L+ +L +
Sbjct: 14 LEQLNEDELKSFKSLL--------WAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSEN 65
Query: 80 QAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQD 139
+ I + MNLT LC+ +AEM E+ Q QE+ +P
Sbjct: 66 WIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNP---------------------- 103
Query: 140 PNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPK 199
EL + EE++ L + + +R +M+ + L W N W
Sbjct: 104 ----ELGDAEEDSE-----------------LAKPGEKEGWRNSMEKQSL-VWKNTFWQG 141
Query: 200 DHVYIRNTSKDEHEELQRLLDPNRTRAQAQ-TIVLVGRAGVGKTTLAMQAMLHWANGVLF 258
D + ++ L+P R T+VL G AGVGKTTLA + ML W + L
Sbjct: 142 DIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
Query: 259 QQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIII 318
Y FYLSC ++ M +FAELIS DWP+ I ++Q +++LF++DG +E+ +
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Query: 319 SESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNP 378
C DW ++ PV +L SLLK++++P A LL+T + +RDL+ P
Sbjct: 261 PPGALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQP 316
Query: 379 CFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQP 438
+V++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 317 IYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQ 376
Query: 439 KVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTF 498
+ D T T L+ F + F G R L LA +GLW+ F
Sbjct: 377 MEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQMSVF 430
Query: 499 NKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVL--EEPREF 556
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + L EE +
Sbjct: 431 HREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDR 490
Query: 557 PPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEEL 616
H+ +++ LL K V F FGL N+ A+ELE T C++SP + +EL
Sbjct: 491 DGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQEL 550
Query: 617 LKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSF 676
L+ L + S+ + + CL+ESQEE+ K ++ E+ +++ E+ SF
Sbjct: 551 LQCKAHLHANKPLSVT-DLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSF 609
Query: 677 CLKHCKRLNKLRLSVSSHI-------LERDLE--------ILETSKFDSR-MHAWNSICS 720
LKHC+ L KL L V+ + E D+E I ++ D R + W CS
Sbjct: 610 SLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCS 669
Query: 721 TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG 780
+N NL L++ S L SSV+ LC + C +QK+ K+VTP+ +D +A G
Sbjct: 670 LFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG 729
Query: 781 NSKLTHLNFSSN-KLGMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQ 838
LTHL + + + T+ L+L LR+ CNL+YL L + + L + Q
Sbjct: 730 KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQ 789
Query: 839 HVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLT 898
+ L L N L D+G LL +T PK L+ L L C+L +CK L+ L+ ++ LT
Sbjct: 790 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 849
Query: 899 HLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILD 958
HL L+KN + D GVKFLCE L PD LQ+L L CS T+ GC L+ AL ++ LD
Sbjct: 850 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 909
Query: 959 LGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLG 1017
L N + G+ +LC+AL+ P+ L L L C+L CQHL S L S++ L L+L
Sbjct: 910 LSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQ 968
Query: 1018 NELDTDGVKMLCKALKKSTCRLQKL 1042
N L G+ L L++ T L+ L
Sbjct: 969 NHLWKSGIIKLFGVLRQRTGSLKIL 993
Score = 101 bits (251), Expect = 4e-21
Identities = 70/219 (31%), Positives = 109/219 (49%), Gaps = 3/219 (1%)
Query: 715 WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQD 773
W L N++L L LS + L L + P+ +Q L+ ++ E +D
Sbjct: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
L L + KLTHL + N +G T V + + L + C L+ L L++C+++ C+ L+
Sbjct: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L +T L L N++ G+ +LC AL +P C L+ L LW C L C+HL ALL
Sbjct: 898 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 956
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
N+ L L+L +N L G+ L L + G+L+ L L
Sbjct: 957 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
Score = 70.9 bits (172), Expect = 6e-12
Identities = 57/182 (31%), Positives = 87/182 (47%), Gaps = 1/182 (0%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQDLII 776
+ + LV ++ L L L+ + + + VK LC L P CK+Q L + + + + L
Sbjct: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
Query: 777 ALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
ALQ LT+L+ S N++ + ++ +AL + CNLK+L L C+L CQ L L S
Sbjct: 898 ALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLS 957
Query: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
Q + L LG N L GI L L +L+ L L + K L + +N
Sbjct: 958 NQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPK 1017
Query: 897 LT 898
LT
Sbjct: 1018 LT 1019
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 465 bits (1197), Expect = e-131
Identities = 335/1061 (31%), Positives = 497/1061 (46%), Gaps = 113/1061 (10%)
Query: 9 PNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNL 68
P G++ Y+ + +L+ FK L + G P I W + A +
Sbjct: 33 PGSPCENGVMLYMRNVSHEELQRFKQLLLTE-------LSTGTMP-ITWDQVETASWAEV 84
Query: 69 SFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQD----PTQEDLEM 124
LL E FP +AW V IF MN +C VR E+ + T E +D TQ +LE
Sbjct: 85 VHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLE- 143
Query: 125 LEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENM 184
E E+G + R+Y+ N+
Sbjct: 144 ------------------------EGESGKI----------------------RRYKSNV 157
Query: 185 KAELLETWDNISWPKDHVYIRNTSKDEHEE-LQRLLDPNRTRA-QAQTIVLVGRAGVGKT 242
+ WD +WP + HEE L LL P R + Q +T+ + G G+GKT
Sbjct: 158 MEKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKT 217
Query: 243 TLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQ 302
LA + M WA + + FY C ++ + +F+ELI WP + + MS+
Sbjct: 218 ILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSK 277
Query: 303 PEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLIT 362
P++LL ++DGFEE+ + + + L+D S DW Q+LP + +L SLL K ++P ATLLI
Sbjct: 278 PDQLLLLLDGFEEL--TSTLIDRLEDLSE--DWRQKLPGSVLLSSLLSKTMLPEATLLIM 333
Query: 363 IKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSC 422
I+ + K L P V + GF + YF +F + E +++L +N LF C
Sbjct: 334 IRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMC 393
Query: 423 SAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRA 482
P+VCW VCS LKQ R +L TS++ + S+LF T + + Q
Sbjct: 394 RVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEG 453
Query: 483 LCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEF 542
LC LA + +W + KED E L+ + + +IL++I FT ++FQEF
Sbjct: 454 LCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEF 513
Query: 543 FAAMSFVLEEPREFPPHSTKPQEMK--MLLQHVLLDK--------EAYWTPVVLFFFGLL 592
FAA+ +VL PQ +K +L HV + + ++Y + + LF FG L
Sbjct: 514 FAALFYVL----------CFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFL 563
Query: 593 NKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTK 652
N+ A +E + CK+S +LLK L K + S + +LF+CLHE +EE F
Sbjct: 564 NEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVS 623
Query: 653 KMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRM 712
+ L +V L I ++E+Q S+FCLK C+ L+++ L+V+ L + K S
Sbjct: 624 QALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVT-------LNFMNVWKLSSSS 676
Query: 713 HA-------------WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
H W +CS TN+ L L ++NS L +K L AL++P+CK+QK
Sbjct: 677 HPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQK 736
Query: 760 LTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLE 818
L + V + QDLI L GN L +L ++ V L+ + LR C L+ L LE
Sbjct: 737 LLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLE 796
Query: 819 KCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQ 878
C + DL L H+ L L N L++ G L A LERL + C
Sbjct: 797 DCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCN 850
Query: 879 LAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTR 938
L C+ L+ L Q++ LTHL+L++N+L+DEG K + AL LQ L L C T
Sbjct: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
Query: 939 EGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACC 997
C ++ +AL N +K LDL N L+DDGV LLCEALK P L L L C T+ CC
Sbjct: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
Query: 998 QHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCR 1038
Q + S+L ++ L +L+L N + G+ LC+A R
Sbjct: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKR 1011
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 461 bits (1186), Expect = e-129
Identities = 331/1030 (32%), Positives = 503/1030 (48%), Gaps = 86/1030 (8%)
Query: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAP-QGHFPRIPWANLRAADPLNLSFLLDEHFPKG 79
L L++ +L+ FK L W+ P + + PW+ + AD L+ +L +
Sbjct: 14 LEQLNEDELKSFKSLL--------WAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSEN 65
Query: 80 QAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQD 139
+ I + MNLT LC+ +AEM E+ Q QE+ +P
Sbjct: 66 WIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNP---------------------- 103
Query: 140 PNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPK 199
EL + EE++ L + + +R +M+ + L W N W
Sbjct: 104 ----ELGDAEEDSE-----------------LAKPGEKEGWRNSMEKQSL-VWKNTFWQG 141
Query: 200 DHVYIRNTSKDEHEELQRLLDPNRTRAQAQ-TIVLVGRAGVGKTTLAMQAMLHWANGVLF 258
D + ++ L+P R T+VL G AGVGKTTLA + ML W + L
Sbjct: 142 DIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
Query: 259 QQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIII 318
Y FYLSC ++ M +FAELIS DWP+ I ++Q +++LF++DG +E+ +
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Query: 319 SESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNP 378
C DW ++ PV +L SLLK++++P A LL+T + +RDL+ P
Sbjct: 261 PPGALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQP 316
Query: 379 CFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQP 438
+V++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 317 IYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQ 376
Query: 439 KVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTF 498
+ D T T L+ F + F G R L LA +GLW+ F
Sbjct: 377 MEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQMSVF 430
Query: 499 NKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVL--EEPREF 556
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + L EE +
Sbjct: 431 HREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDR 490
Query: 557 PPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEEL 616
H+ +++ LL K V F FGL N+ A+ELE T C++SP + +EL
Sbjct: 491 DGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQEL 550
Query: 617 LKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSF 676
L+ L + S+ + + CL+ESQEE+ K ++ E+ +++ E+ SF
Sbjct: 551 LQCKAHLHANKPLSVT-DLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSF 609
Query: 677 CLKHCKRLNKLRLSVSSHI-LERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSN 735
LKHC+ L KL L V+ + LE ++ +F+S +N NL L++
Sbjct: 610 SLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFES-------------SNSNLKFLEVKQ 656
Query: 736 SKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSN-KL 794
S L SSV+ LC + C +QK+ K+VTP+ +D +A G LTHL + + +
Sbjct: 657 SFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEW 716
Query: 795 GMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDD 853
T+ L+L LR+ CNL+YL L + + L + Q + L L N L D+
Sbjct: 717 ERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDE 776
Query: 854 GIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVK 913
G LL +T PK L+ L L C+L +CK L+ L+ ++ LTHL L+KN + D GVK
Sbjct: 777 GAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVK 836
Query: 914 FLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLC 973
FLCE L PD LQ+L L CS T+ GC L+ AL ++ LDL N + G+ +LC
Sbjct: 837 FLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILC 895
Query: 974 EALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKAL 1032
+AL+ P+ L L L C+L CQHL S L S++ L L+L N L G+ L L
Sbjct: 896 QALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVL 955
Query: 1033 KKSTCRLQKL 1042
++ T L+ L
Sbjct: 956 RQRTGSLKIL 965
Score = 101 bits (251), Expect = 4e-21
Identities = 70/219 (31%), Positives = 109/219 (49%), Gaps = 3/219 (1%)
Query: 715 WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQD 773
W L N++L L LS + L L + P+ +Q L+ ++ E +D
Sbjct: 750 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 809
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
L L + KLTHL + N +G T V + + L + C L+ L L++C+++ C+ L+
Sbjct: 810 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 869
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L +T L L N++ G+ +LC AL +P C L+ L LW C L C+HL ALL
Sbjct: 870 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 928
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
N+ L L+L +N L G+ L L + G+L+ L L
Sbjct: 929 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967
Score = 70.9 bits (172), Expect = 6e-12
Identities = 57/182 (31%), Positives = 87/182 (47%), Gaps = 1/182 (0%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQDLII 776
+ + LV ++ L L L+ + + + VK LC L P CK+Q L + + + + L
Sbjct: 810 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 869
Query: 777 ALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
ALQ LT+L+ S N++ + ++ +AL + CNLK+L L C+L CQ L L S
Sbjct: 870 ALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLS 929
Query: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
Q + L LG N L GI L L +L+ L L + K L + +N
Sbjct: 930 NQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPK 989
Query: 897 LT 898
LT
Sbjct: 990 LT 991
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 459 bits (1180), Expect = e-129
Identities = 320/1019 (31%), Positives = 500/1019 (49%), Gaps = 124/1019 (12%)
Query: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
L YL L+ L++FK+ LE PQ +P AD ++L+ L+ +
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 77 PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+ +AW + + IF +N L EK R E K + +PT
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
Query: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188
CQ+ D +EEE G + + D+R+KYR+ +++
Sbjct: 108 -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
Query: 189 LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225
+++S K + +R + S+ E E+ ++ L DP+
Sbjct: 156 ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
Query: 226 AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284
++ T+V G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++ + + + +L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
Query: 285 ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342
I PD + PI + + +P ++LF++DGF+E+ + D+ G CTDW +
Sbjct: 276 IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
Query: 343 KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402
+L SL++K+L+P A+LLIT + + L+ L +P V+I GF+ + YF ++F D
Sbjct: 330 ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
Query: 403 SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462
++ +++NE LF C P+VCW VC+ LKQ L ++TTT++Y +F S+
Sbjct: 390 AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
Query: 463 LFS----TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518
L + E L W LCSLA +G+W+ F + D GL+ + +
Sbjct: 450 LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
Query: 519 FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572
N+ QK DC +F H++FQEFFAAM ++LEE +E P K +++ +LL++
Sbjct: 505 MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
Query: 573 VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632
++ Y VV F FGL+N+ LE L CKIS ++ ELLKW E KA+ +Q
Sbjct: 565 YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
Query: 633 FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692
L LF+CL+E QEEDF ++ + ++++N+ + SSFC+++C R+ L L
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
Query: 693 SHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKN 752
++ + + E E H LD+ L +SS L
Sbjct: 685 HNMPKEEEE---------------------EEKEGRH-LDMVQCVLPSSSHAACSHGLG- 721
Query: 753 PRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACN 811
RC + C D+ + L N KL L+ S N LG + L+ L+H CN
Sbjct: 722 -RCGLSHECCF---------DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCN 771
Query: 812 LKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALER 871
LK L L C L++A CQDLA L++ +TRL +G N L D G+ +LC +P+C L++
Sbjct: 772 LKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQK 831
Query: 872 LELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
L L L + C LS L N++LTHL L N+L D+G+K LCE L PD LQ L L
Sbjct: 832 LGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
Query: 932 SGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRA-LHTLGLAK 989
C+ T C +L+ L+ + +++ L LG NDL D GV + CE LK L LGL++
Sbjct: 892 DNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 171 bits (433), Expect = 3e-42
Identities = 104/247 (42%), Positives = 137/247 (55%), Gaps = 4/247 (1%)
Query: 798 VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKL 857
V +L + H+AC+ L +C LS C D++L L+S Q + L L N L D GI+L
Sbjct: 704 VQCVLPSSSHAACSHG---LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
LC L H C L++L L C L + C+ L+ L + SLT L + +N+L D GV LCE
Sbjct: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
Query: 918 ALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEA-L 976
P NLQ L L T C L++ LS N N+ L L N L D G+KLLCE L
Sbjct: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
Query: 977 KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKST 1036
P L L L CNLT+ CC L ++L+SS+SL L+L N+L GV M C+ LK+ +
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
Query: 1037 CRLQKLG 1043
C LQ LG
Sbjct: 941 CLLQNLG 947
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 446 bits (1146), Expect = e-125
Identities = 316/1019 (31%), Positives = 496/1019 (48%), Gaps = 124/1019 (12%)
Query: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
L YL L+ L++FK+ LE PQ +P AD ++L+ L+ +
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 77 PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+ +AW + + IF +N L EK R E K + +PT
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
Query: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188
CQ+ D +EEE G + + D+R+KYR+ +++
Sbjct: 108 -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
Query: 189 LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225
+++S K + +R + S+ E E+ ++ L DP+
Sbjct: 156 ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
Query: 226 AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284
++ T+V G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++ + + + +L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
Query: 285 ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342
I PD + PI + + +P ++LF++DGF+E+ + D+ G CTDW +
Sbjct: 276 IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
Query: 343 KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402
+L SL++K+L+P A+LLIT + + L+ L +P V+I GF+ + YF ++F D
Sbjct: 330 ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
Query: 403 SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462
++ +++NE LF C P+VCW VC+ LKQ L ++TTT++Y +F S+
Sbjct: 390 AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
Query: 463 LFS----TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518
L + E L W LCSLA +G+W+ F + D GL+ + +
Sbjct: 450 LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
Query: 519 FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572
N+ QK DC +F H++FQEFFAAM ++LEE +E P K +++ +LL++
Sbjct: 505 MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
Query: 573 VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632
++ Y VV F FGL+N+ LE L CKIS ++ ELLKW E KA+ +Q
Sbjct: 565 YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
Query: 633 FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692
L LF+CL+E QEEDF ++ + ++++N+ + SSFC+++C R+ L L
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
Query: 693 SHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKN 752
++ + + E E H LD+ L +SS L N
Sbjct: 685 HNMPKEEEE---------------------EEKEGRH-LDMVQCVLPSSSHAACSHGLVN 722
Query: 753 PRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACN 811
+ C+ L L + LT L+ S N LG + ++ + L+H CN
Sbjct: 723 SH--LTSSFCRG---------LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCN 771
Query: 812 LKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALER 871
++ L L +C LS C D++L L+S Q + L L N L D GI+LLC L H C L++
Sbjct: 772 IRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKK 831
Query: 872 LELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
L L L + C LS L N++LTHL L N+L D+G+K LCE L PD LQ L L
Sbjct: 832 LWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
Query: 932 SGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRA-LHTLGLAK 989
C+ T C +L+ L+ + +++ L LG NDL D GV + CE LK L LGL++
Sbjct: 892 DNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 156 bits (395), Expect = 8e-38
Identities = 98/247 (39%), Positives = 136/247 (55%), Gaps = 4/247 (1%)
Query: 798 VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKL 857
V +L + H+AC+ L +L+++ C+ L L++ Q +T L L N L D G+++
Sbjct: 704 VQCVLPSSSHAACSHG---LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
Query: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
LC L HP C + RL L C L+ C +S L N+ L L+LS N+L D G++ LC
Sbjct: 761 LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
Query: 918 ALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEA-L 976
L NL+ L L T C L++ LS N N+ L L N L D G+KLLCE L
Sbjct: 821 GLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
Query: 977 KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKST 1036
P L L L CNLT+ CC L ++L+SS+SL L+L N+L GV M C+ LK+ +
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
Query: 1037 CRLQKLG 1043
C LQ LG
Sbjct: 941 CLLQNLG 947
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 443 bits (1139), Expect = e-124
Identities = 312/979 (31%), Positives = 475/979 (48%), Gaps = 87/979 (8%)
Query: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAP-QGHFPRIPWANLRAADPLNLSFLLDEHFPKG 79
L L++ +L+ FK L W+ P + + PW+ + AD L+ +L +
Sbjct: 14 LEQLNEDELKSFKSLL--------WAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSEN 65
Query: 80 QAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQD 139
+ I + MNLT LC+ +AEM E+ Q QE+ +P
Sbjct: 66 WIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNP---------------------- 103
Query: 140 PNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPK 199
EL + EE++ L + + +R +M+ + L W N W
Sbjct: 104 ----ELGDAEEDSE-----------------LAKPGEKEGWRNSMEKQSL-VWKNTFWQG 141
Query: 200 DHVYIRNTSKDEHEELQRLLDPNRTRAQAQ-TIVLVGRAGVGKTTLAMQAMLHWANGVLF 258
D + ++ L+P R T+VL G AGVGKTTLA + ML W + L
Sbjct: 142 DIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
Query: 259 QQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIII 318
Y FYLSC ++ M +FAELIS DWP+ I ++Q +++LF++DG +E+ +
Sbjct: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Query: 319 SESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNP 378
C DW ++ PV +L SLLK++++P A LL+T + +RDL+ P
Sbjct: 261 PPGALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQP 316
Query: 379 CFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQP 438
+V++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 317 IYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQ 376
Query: 439 KVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTF 498
+ D T T L+ F + F G R L LA +GLW+ F
Sbjct: 377 MEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQMSVF 430
Query: 499 NKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVL--EEPREF 556
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + L EE +
Sbjct: 431 HREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDR 490
Query: 557 PPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEEL 616
H+ +++ LL K V F FGL N+ A+ELE T C++SP + +EL
Sbjct: 491 DGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQEL 550
Query: 617 LKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSF 676
L+ L + S+ + + CL+ESQEE+ K ++ E+ +++ E+ SF
Sbjct: 551 LQCKAHLHANKPLSVT-DLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSF 609
Query: 677 CLKHCKRLNKLRLSVSSHI-------LERDLE--------ILETSKFDSR-MHAWNSICS 720
LKHC+ L KL L V+ + E D+E I ++ D R + W CS
Sbjct: 610 SLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCS 669
Query: 721 TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG 780
+N NL L++ S L SSV+ LC + C +QK+ K+VTP+ +D +A G
Sbjct: 670 LFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG 729
Query: 781 NSKLTHLNFSSN-KLGMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQ 838
LTHL + + + T+ L+L LR+ CNL+YL L + + L + Q
Sbjct: 730 KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQ 789
Query: 839 HVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLT 898
+ L L N L D+G LL +T PK L+ L L C+L +CK L+ L+ ++ LT
Sbjct: 790 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 849
Query: 899 HLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILD 958
HL L+KN + D GVKFLCE L PD LQ+L L CS T+ GC L+ AL ++ LD
Sbjct: 850 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 909
Query: 959 LGENDLQDDGVKLLCEALK 977
L N + G+ +LC+AL+
Sbjct: 910 LSINQIA-RGLWILCQALE 927
Score = 94.4 bits (233), Expect = 5e-19
Identities = 67/197 (34%), Positives = 97/197 (49%), Gaps = 7/197 (3%)
Query: 850 LQDDGIKLLCAALTHPKCALERLELWFCQLAAP--ACKHLSDALLQNRSLTHLNLSKNSL 907
L D +++LC +T C L+++E+ + P A + A + ++LTHL L+ +
Sbjct: 687 LSDSSVRILCDHVTRSTCHLQKVEI---KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIE 743
Query: 908 RDEGVKF-LCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQD 966
+ + LC+ L NLQ L L G T E E L N ++K L L N L D
Sbjct: 744 WERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLD 803
Query: 967 DGVKLLCEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGV 1025
+G LL + + +P L L L C LT A C+ L +VL SK L +L L N + GV
Sbjct: 804 EGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGV 863
Query: 1026 KMLCKALKKSTCRLQKL 1042
K LC+ L C+LQ L
Sbjct: 864 KFLCEGLSYPDCKLQTL 880
Score = 67.0 bits (162), Expect = 9e-11
Identities = 53/186 (28%), Positives = 87/186 (46%), Gaps = 3/186 (1%)
Query: 715 WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQD 773
W L N++L L LS + L L + P+ +Q L+ ++ E +D
Sbjct: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
L L + KLTHL + N +G T V + + L + C L+ L L++C+++ C+ L+
Sbjct: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L +T L L N++ G+ +LC AL +P C L+ L L + K L +
Sbjct: 898 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
Query: 893 QNRSLT 898
+N LT
Sbjct: 957 KNPKLT 962
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 418 bits (1075), Expect = e-116
Identities = 270/867 (31%), Positives = 440/867 (50%), Gaps = 21/867 (2%)
Query: 184 MKAELLETWDNISWPKDHV-YIRNTSKDEHEELQRLLDPNRT-RAQAQTIVLVGRAGVGK 241
M+ + + W++ ++ K H + R+ S D LQ D A + L+G GK
Sbjct: 100 MRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGK 159
Query: 242 TTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMS 301
T + A+L W G ++Q SYV +L+ H+I M ++ AELI+ DWPD API + +S
Sbjct: 160 TIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILS 219
Query: 302 QPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLI 361
P+KLLFI++ + I + +ES + C++ Q++P+ +L SLLK+++ P LI
Sbjct: 220 DPKKLLFILEDLDNIRFELNVNES----ALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLI 275
Query: 362 TIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHS 421
+ + ++K L + +YF F D LQ + ++E L
Sbjct: 276 SSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGL 335
Query: 422 CSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWR 481
C ++CW C+ LK+ + D Q QT T L+A+F ++ ++ A+ G +
Sbjct: 336 CRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLK 395
Query: 482 ALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQE 541
LC LA GL+ F+ ED G + L NIL N F HL+ QE
Sbjct: 396 RLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQE 455
Query: 542 FFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELE 601
F A++F++ P P ++ + K ++ + + V F FGLLN N + LE
Sbjct: 456 FCTAIAFLMAVPNYLIPSGSREYKEKR-------EQYSDFNQVFTFIFGLLNANRRKILE 508
Query: 602 DTLHCKISPRVMEELLKW---GEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRI 658
+ ++ M + KW G H + LF+CL+E++EE+F K ++ +
Sbjct: 509 TSFGYQLP---MVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDAL 565
Query: 659 FEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNSI 718
EV + + D+++ S +CL +C L L+LSV ++ I T+ + W I
Sbjct: 566 MEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREI 625
Query: 719 CSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIAL 778
CS T E+L EL + ++ L+ S + L AL++ CK++ L V+ +DL+ AL
Sbjct: 626 CSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKAL 685
Query: 779 QGNSKLTHLNFSSNKLGMTVPLILKALRHS-ACNLKYLCLEKCNLSAASCQDLALFLTSI 837
N LT+L+ + + + + +L + H C + +L L KC+L A+ C+++A L S
Sbjct: 686 ARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISG 745
Query: 838 QHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSL 897
+ +L L N L+ DG+ +LC AL HP C L L L FC L C L LL + +L
Sbjct: 746 GSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTL 805
Query: 898 THLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKIL 957
L+L N L++ GV + L P L+ L+LSGC F+ + C +A ++ N ++ L
Sbjct: 806 RQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSL 865
Query: 958 DLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLL 1016
++G N ++D G++LLC L+ P+ L +GL +C LT+ACC+ L SVL+++K+L LNLL
Sbjct: 866 EIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLL 925
Query: 1017 GNELDTDGVKMLCKALKKSTCRLQKLG 1043
N L DGV L ++L C L+ +G
Sbjct: 926 QNHLGNDGVAKLLESLISPDCVLKVVG 952
Score = 104 bits (259), Expect = 5e-22
Identities = 99/389 (25%), Positives = 166/389 (42%), Gaps = 52/389 (13%)
Query: 566 MKMLLQHVLLDKE-------------AYWTPVVLFFFGLLNKNIARELEDTLHCKISPRV 612
+K+ +Q + +KE YW + F+ + + ++ L+ IS R+
Sbjct: 594 LKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLN-GISERI 652
Query: 613 MEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQ 672
+ + L E +S + L+L + S ED K + L+I
Sbjct: 653 LSKAL---------EHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSI------- 696
Query: 673 ASSFCLKHCKRLNKLRLSVSSHILER---DLEILETSKFDSRMHAWNSICSTLVTNENLH 729
+C ++ S+ IL + L K D R I S L++ +L
Sbjct: 697 -------NCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLR 749
Query: 730 ELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCK-SVTPEWVLQDLIIALQGNSKLTHLN 788
+L LS++ L + + LC AL +P C + L E L L + L L+
Sbjct: 750 KLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLD 809
Query: 789 FSSNKLG------MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTR 842
N+L +T PL+ C L+ L L C S+ CQ +A+ + + + +
Sbjct: 810 LCVNRLKNYGVLHVTFPLLFPT-----CQLEELHLSGCFFSSDICQYIAIVIATNEKLRS 864
Query: 843 LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNL 902
L +G N+++D G++LLC L HP C L + L C L + C+ L+ L N++L LNL
Sbjct: 865 LEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNL 924
Query: 903 SKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
+N L ++GV L E+L PD L+ + L
Sbjct: 925 LQNHLGNDGVAKLLESLISPDCVLKVVGL 953
Score = 32.3 bits (72), Expect = 2.4
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 12/97 (12%)
Query: 13 TNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL 72
T+ LL YL L + + FK L ++++DF PQ FP I A+ L +S+
Sbjct: 7 TDFDLLWYLENLSDKEFQSFKKYLA-RKILDF-KLPQ--FPLIQMTKEELANVLPISY-- 60
Query: 73 DEHFPKGQ-AWKVVLGIFQTMNLTSLCEKVRAEMKEN 108
+GQ W ++ IF M LC K+ N
Sbjct: 61 -----EGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRN 92
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 409 bits (1052), Expect = e-114
Identities = 298/968 (30%), Positives = 463/968 (47%), Gaps = 123/968 (12%)
Query: 17 LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76
L YL L+ L++FK+ LE PQ +P AD ++L+ L+ +
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
Query: 77 PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
+ +AW + + IF +N L EK R E K + +PT
Sbjct: 63 GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
Query: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188
CQ+ D +EEE G + + D+R+KYR+ +++
Sbjct: 108 -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
Query: 189 LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225
+++S K + +R + S+ E E+ ++ L DP+
Sbjct: 156 ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
Query: 226 AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284
++ T+V G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++ + + + +L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
Query: 285 ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342
I PD + PI + + +P ++LF++DGF+E+ + D+ G CTDW +
Sbjct: 276 IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
Query: 343 KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402
+L SL++K+L+P A+LLIT + + L+ L +P V+I GF+ + YF ++F D
Sbjct: 330 ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
Query: 403 SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462
++ +++NE LF C P+VCW VC+ LKQ L ++TTT++Y +F S+
Sbjct: 390 AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
Query: 463 LFS----TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518
L + E L W LCSLA +G+W+ F + D GL+ + +
Sbjct: 450 LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
Query: 519 FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572
N+ QK DC +F H++FQEFFAAM ++LEE +E P K +++ +LL++
Sbjct: 505 MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
Query: 573 VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632
++ Y VV F FGL+N+ LE L CKIS ++ ELLKW E KA+ +Q
Sbjct: 565 YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
Query: 633 FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692
L LF+CL+E QEEDF ++ + ++++N+ + SSFC+++C R+ L L
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
Query: 693 SHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKN 752
++ + + E E H LD+ L +SS L
Sbjct: 685 HNMPKEEEE---------------------EEKEGRH-LDMVQCVLPSSSHAACSHGLG- 721
Query: 753 PRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACN 811
RC + C D+ + L N KL L+ S N LG + L+ L+H CN
Sbjct: 722 -RCGLSHECCF---------DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCN 771
Query: 812 LKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALER 871
LK L L L++ C L+ L++ Q++T L L N L D GIKLLC L HP C L+
Sbjct: 772 LKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQV 831
Query: 872 LELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
LEL C L + C LS L ++SL L+L N L D GV CE L + LQ+L L
Sbjct: 832 LELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Query: 932 SGCSFTRE 939
S F E
Sbjct: 892 SEMYFNYE 899
Score = 132 bits (333), Expect = 1e-30
Identities = 79/193 (40%), Positives = 108/193 (55%), Gaps = 4/193 (2%)
Query: 798 VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKL 857
V +L + H+AC+ L +C LS C D++L L+S Q + L L N L D GI+L
Sbjct: 704 VQCVLPSSSHAACSHG---LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
LC L H C L++L L L + C LS L N++LTHL L N+L D+G+K LCE
Sbjct: 761 LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 820
Query: 918 ALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK 977
L PD LQ L L C+ T C +L+ L+ + +++ L LG NDL D GV + CE LK
Sbjct: 821 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 880
Query: 978 PHRA-LHTLGLAK 989
L LGL++
Sbjct: 881 QQSCLLQNLGLSE 893
Score = 116 bits (291), Expect = 1e-25
Identities = 75/192 (39%), Positives = 103/192 (53%), Gaps = 4/192 (2%)
Query: 853 DGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGV 912
D ++ + + +H C+ L C L+ C +S L N+ L L+LS N+L D G+
Sbjct: 702 DMVQCVLPSSSHAACSHG---LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
Query: 913 KFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLL 972
+ LC L NL+ L L T C L++ LS N N+ L L N L D G+KLL
Sbjct: 759 RLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 818
Query: 973 CEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKA 1031
CE L P L L L CNLT+ CC L ++L+SS+SL L+L N+L GV M C+
Sbjct: 819 CEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEV 878
Query: 1032 LKKSTCRLQKLG 1043
LK+ +C LQ LG
Sbjct: 879 LKQQSCLLQNLG 890
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 337 bits (863), Expect = 5e-92
Identities = 227/694 (32%), Positives = 347/694 (50%), Gaps = 49/694 (7%)
Query: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
Query: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
Query: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
Query: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
Query: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
Query: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
Query: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
Query: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
Query: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
Query: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQ--KLTCKSVTPEWVLQDLIIALQGN 781
NL ELDLS + L S+VK LC L+ PRC ++ +L +T E +DL L+ N
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE-DCKDLAFGLRAN 864
Query: 782 SKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
LT L+ S N L + + LR +C L+ L L C L++ CQDLA L++ +
Sbjct: 865 QTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Query: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874
L L N L D G++LLC L HP C L RL L
Sbjct: 925 KELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 116 bits (291), Expect = 1e-25
Identities = 74/172 (43%), Positives = 95/172 (55%), Gaps = 5/172 (2%)
Query: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 950 HNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHL 1000
+ ++K LDL +N+L D GV+LLCE L+ P L LGL + L+ Q L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 43.9 bits (102), Expect = 8e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
Score = 35.4 bits (80), Expect = 0.28
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
+ S L + +L ELDL + L V+ LC L++P CK+ +L T ++ + A
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
Query: 778 LQGNSKLTHLNFSSNKLGMTVP 799
L+ K L FS K + P
Sbjct: 974 LE-QEKPQLLIFSRRKPSVMTP 994
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 337 bits (863), Expect = 5e-92
Identities = 227/694 (32%), Positives = 347/694 (50%), Gaps = 49/694 (7%)
Query: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
Query: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
Query: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
Query: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
Query: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
Query: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
Query: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
Query: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
Query: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
Query: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQ--KLTCKSVTPEWVLQDLIIALQGN 781
NL ELDLS + L S+VK LC L+ PRC ++ +L +T E +DL L+ N
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE-DCKDLAFGLRAN 864
Query: 782 SKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
LT L+ S N L + + LR +C L+ L L C L++ CQDLA L++ +
Sbjct: 865 QTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Query: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874
L L N L D G++LLC L HP C L RL L
Sbjct: 925 KELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 116 bits (291), Expect = 1e-25
Identities = 74/172 (43%), Positives = 95/172 (55%), Gaps = 5/172 (2%)
Query: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 950 HNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHL 1000
+ ++K LDL +N+L D GV+LLCE L+ P L LGL + L+ Q L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 43.9 bits (102), Expect = 8e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
Score = 35.4 bits (80), Expect = 0.28
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
+ S L + +L ELDL + L V+ LC L++P CK+ +L T ++ + A
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
Query: 778 LQGNSKLTHLNFSSNKLGMTVP 799
L+ K L FS K + P
Sbjct: 974 LE-QEKPQLLIFSRRKPSVMTP 994
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 337 bits (863), Expect = 5e-92
Identities = 227/694 (32%), Positives = 347/694 (50%), Gaps = 49/694 (7%)
Query: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
Query: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
Query: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
Query: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
Query: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
Query: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
Query: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
Query: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
Query: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
Query: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQ--KLTCKSVTPEWVLQDLIIALQGN 781
NL ELDLS + L S+VK LC L+ PRC ++ +L +T E +DL L+ N
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE-DCKDLAFGLRAN 864
Query: 782 SKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
LT L+ S N L + + LR +C L+ L L C L++ CQDLA L++ +
Sbjct: 865 QTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Query: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874
L L N L D G++LLC L HP C L RL L
Sbjct: 925 KELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 116 bits (291), Expect = 1e-25
Identities = 74/172 (43%), Positives = 95/172 (55%), Gaps = 5/172 (2%)
Query: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 950 HNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHL 1000
+ ++K LDL +N+L D GV+LLCE L+ P L LGL + L+ Q L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 43.9 bits (102), Expect = 8e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
Score = 35.4 bits (80), Expect = 0.28
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
+ S L + +L ELDL + L V+ LC L++P CK+ +L T ++ + A
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
Query: 778 LQGNSKLTHLNFSSNKLGMTVP 799
L+ K L FS K + P
Sbjct: 974 LE-QEKPQLLIFSRRKPSVMTP 994
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 336 bits (861), Expect = 8e-92
Identities = 226/692 (32%), Positives = 346/692 (50%), Gaps = 49/692 (7%)
Query: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
Query: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
Query: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
Query: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
Query: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
Query: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
Query: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
Query: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
Query: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
Query: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQ--KLTCKSVTPEWVLQDLIIALQGN 781
NL ELDLS + L S+VK LC L+ PRC ++ +L +T E +DL L+ N
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE-DCKDLAFGLRAN 864
Query: 782 SKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
LT L+ S N L + + LR +C L+ L L C L++ CQDLA L++ +
Sbjct: 865 QTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Query: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
L L N L D G++LLC L HP C L RL
Sbjct: 925 KELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 118 bits (295), Expect = 3e-26
Identities = 77/190 (40%), Positives = 103/190 (54%), Gaps = 5/190 (2%)
Query: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 950 HNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKS 1009
+ ++K LDL +N+L D GV+LLCE L+ H A + L K ++ T +S+S S
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLGKPSVMTPTEGLDTGEMSNSTS 978
Query: 1010 LVNLNLLGNE 1019
+ LG+E
Sbjct: 979 SLKRQRLGSE 988
Score = 43.9 bits (102), Expect = 8e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
Score = 33.9 bits (76), Expect = 0.82
Identities = 18/48 (37%), Positives = 27/48 (56%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSV 765
+ S L + +L ELDL + L V+ LC L++P CK+ +L SV
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV 961
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 336 bits (861), Expect = 8e-92
Identities = 226/692 (32%), Positives = 346/692 (50%), Gaps = 49/692 (7%)
Query: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
Query: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
Query: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
Query: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
Query: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
Query: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
Query: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
Query: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
Query: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
Query: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQ--KLTCKSVTPEWVLQDLIIALQGN 781
NL ELDLS + L S+VK LC L+ PRC ++ +L +T E +DL L+ N
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE-DCKDLAFGLRAN 864
Query: 782 SKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHV 840
LT L+ S N L + + LR +C L+ L L C L++ CQDLA L++ +
Sbjct: 865 QTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Query: 841 TRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
L L N L D G++LLC L HP C L RL
Sbjct: 925 KELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 118 bits (295), Expect = 3e-26
Identities = 77/190 (40%), Positives = 103/190 (54%), Gaps = 5/190 (2%)
Query: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 950 HNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKS 1009
+ ++K LDL +N+L D GV+LLCE L+ H A + L K ++ T +S+S S
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLGKPSVMTPTEGLDTGEMSNSTS 978
Query: 1010 LVNLNLLGNE 1019
+ LG+E
Sbjct: 979 SLKRQRLGSE 988
Score = 43.9 bits (102), Expect = 8e-04
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
Score = 33.9 bits (76), Expect = 0.82
Identities = 18/48 (37%), Positives = 27/48 (56%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSV 765
+ S L + +L ELDL + L V+ LC L++P CK+ +L SV
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV 961
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 228 bits (581), Expect = 2e-59
Identities = 197/716 (27%), Positives = 325/716 (45%), Gaps = 67/716 (9%)
Query: 209 KDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYL 268
+ + RL + + T+VL G AG+GKT A + + WA G L+Q + + F++
Sbjct: 176 RSDTHTFNRLFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFM 235
Query: 269 SCHKIRYMKET-TFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLD 327
C ++ T + A+LI PD AP+ + ++QP++LLFI+DG +E+
Sbjct: 236 PCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGG-----P 290
Query: 328 DGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFT 387
+ +PCTD ++ ++L LL K L+P A LL+T + L+ L +P ++ GF+
Sbjct: 291 EAAPCTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFS 350
Query: 388 GDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQS 447
D + YF + F D E+ + +++NETLF C P VCW VC+ L+Q DL
Sbjct: 351 DKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSR 410
Query: 448 ITQTTTSLYAYFFSNLFSTAEVDLAD-DSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIE 506
++TTTS+Y F +++ S+A V AD G R LC LA EG+ F +++ E
Sbjct: 411 TSKTTTSVYLLFITSVLSSAPV--ADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQL 468
Query: 507 GLEVPFIDSLY-EFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEE---PREFPPHSTK 562
L + +L+ L + + F SFQEF AA+S++LE+ PR T
Sbjct: 469 ELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLEDGGVPR------TA 522
Query: 563 PQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKW--- 619
+ LL+ ++ F FGLL+ R++E C +S RV +E L+W
Sbjct: 523 AGGVGTLLRGD-AQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQG 581
Query: 620 ---------------------GEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRI 658
EE + E + L L +CL+E+QE+ F ++ L R
Sbjct: 582 QGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRF 641
Query: 659 FEVDLNILE--DEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSK-FDSRMHAW 715
E+ L + ++ S+C++ C LRL + ++ + K + +
Sbjct: 642 PELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGG 701
Query: 716 NSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT---CKSVTPEWVLQ 772
+S T +L AS + L A+ +P C + LT CK P+ V +
Sbjct: 702 SSSQGT-------------TKQLPASLLHPLFQAMTDPLCHLSSLTLSHCK--LPDAVCR 746
Query: 773 DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLA 831
DL AL+ LT L N+L + ++ + L C ++ + ++ + Q L
Sbjct: 747 DLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPD-PQRGLQYLV 805
Query: 832 LFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
L +T L L +L + LCA L H C L+ L L +L+ + + L
Sbjct: 806 GMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQEL 861
Score = 65.1 bits (157), Expect = 3e-10
Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 5/146 (3%)
Query: 801 ILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCA 860
+ +A+ C+L L L C L A C+DL+ L + +T L L NRL + G+++L
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 861 ALTHPKCALERLELWFCQLAAP--ACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEA 918
L P+C ++ + + QL P ++L L Q+ +LT L+LS L V +LC
Sbjct: 779 GLAWPQCRVQTVRV---QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAV 835
Query: 919 LGRPDGNLQSLNLSGCSFTREGCGEL 944
L LQ+L+L+ + + EL
Sbjct: 836 LQHQGCGLQTLSLASVELSEQSLQEL 861
Score = 61.2 bits (147), Expect = 5e-09
Identities = 50/156 (32%), Positives = 70/156 (44%), Gaps = 4/156 (2%)
Query: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
L A+T P C L L L C+L C+ LS+AL +LT L L N L + G++ L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 918 ALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK 977
L P +Q++ + + G L L + + LDL L V LC L+
Sbjct: 779 GLAWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 978 PHR--ALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
H+ L TL LA L+ Q L +V + LV
Sbjct: 838 -HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLV 872
Score = 47.8 bits (112), Expect = 6e-05
Identities = 40/129 (31%), Positives = 60/129 (46%), Gaps = 2/129 (1%)
Query: 915 LCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCE 974
L +A+ P +L SL LS C C +L+ AL + L L N L + G+++L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 975 ALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALK 1033
L P + T+ + + Q+L +L S +L L+L G +L V LC L+
Sbjct: 779 GLAWPQCRVQTVRVQLPDPQRGL-QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 1034 KSTCRLQKL 1042
C LQ L
Sbjct: 838 HQGCGLQTL 846
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 183 bits (464), Expect = 8e-46
Identities = 130/468 (27%), Positives = 221/468 (47%), Gaps = 31/468 (6%)
Query: 175 DHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDP------------- 221
D+R YRE+++ LE W + + +K E + L P
Sbjct: 97 DYREVYREHVRC--LEEWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEA 154
Query: 222 -----NRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYM 276
+ +VL G AG GKTTLA + +L WA G L+ RF YVFY+SC ++ +
Sbjct: 155 LFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLL 214
Query: 277 KETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWY 336
E+ +L+ D AP+ E + QPE+LLFI+DGF+E + E L
Sbjct: 215 LESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE--LQRPFEEKLKKRGLS---- 268
Query: 337 QELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFM 396
P +LH L+++ +P +LLIT + +R+L+ L V I GF+ ++ YF
Sbjct: 269 ---PKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
Query: 397 RHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLY 456
+F D + ++ ++KN+ L+ +C P +CW VCS L+ R + + +T ++
Sbjct: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
Query: 457 -AYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDS 515
AY + L + ++ S R+LCSLA EG+ F F + + L+ P + +
Sbjct: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
Query: 516 LYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLL 575
N Q +F H+SFQ+FF AMS++++E + ++ +E++ LL+
Sbjct: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR-REVQRLLEVKEQ 504
Query: 576 DKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEEL 623
+ T + F + K+ LE +ISP + ++L + E++
Sbjct: 505 EGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQM 552
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 175 bits (443), Expect = 2e-43
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1012 NLNLLGNELDTDGVKMLCKAL 1032
L + N L+ GV+ LC+ L
Sbjct: 345 ELQISNNRLEDAGVRELCQGL 365
Score = 169 bits (429), Expect = 1e-41
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
Query: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
Score = 150 bits (378), Expect = 8e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
Query: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 955 KILDLGENDLQDDGVKLLCEALK 977
+ LDL N L D G+ L E+++
Sbjct: 401 RELDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
Query: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
Query: 760 LTCKSVTPEWVLQDLIIALQ 779
L + ++D + AL+
Sbjct: 432 LVLYDIYWSEEMEDRLQALE 451
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 175 bits (443), Expect = 2e-43
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1012 NLNLLGNELDTDGVKMLCKAL 1032
L + N L+ GV+ LC+ L
Sbjct: 345 ELQISNNRLEDAGVRELCQGL 365
Score = 169 bits (429), Expect = 1e-41
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
Query: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
Score = 150 bits (378), Expect = 8e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
Query: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 955 KILDLGENDLQDDGVKLLCEALK 977
+ LDL N L D G+ L E+++
Sbjct: 401 RELDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
Query: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
Query: 760 LTCKSVTPEWVLQDLIIALQ 779
L + ++D + AL+
Sbjct: 432 LVLYDIYWSEEMEDRLQALE 451
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 175 bits (443), Expect = 2e-43
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1012 NLNLLGNELDTDGVKMLCKAL 1032
L + N L+ GV+ LC+ L
Sbjct: 345 ELQISNNRLEDAGVRELCQGL 365
Score = 169 bits (429), Expect = 1e-41
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
Query: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
Score = 150 bits (378), Expect = 8e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
Query: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 955 KILDLGENDLQDDGVKLLCEALK 977
+ LDL N L D G+ L E+++
Sbjct: 401 RELDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
Query: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
Query: 760 LTCKSVTPEWVLQDLIIALQ 779
L + ++D + AL+
Sbjct: 432 LVLYDIYWSEEMEDRLQALE 451
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 175 bits (443), Expect = 2e-43
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1012 NLNLLGNELDTDGVKMLCKAL 1032
L + N L+ GV+ LC+ L
Sbjct: 345 ELQISNNRLEDAGVRELCQGL 365
Score = 169 bits (429), Expect = 1e-41
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
Query: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
Score = 150 bits (378), Expect = 8e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
Query: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 955 KILDLGENDLQDDGVKLLCEALK 977
+ LDL N L D G+ L E+++
Sbjct: 401 RELDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
Query: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
Query: 760 LTCKSVTPEWVLQDLIIALQ 779
L + ++D + AL+
Sbjct: 432 LVLYDIYWSEEMEDRLQALE 451
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 175 bits (443), Expect = 2e-43
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1012 NLNLLGNELDTDGVKMLCKAL 1032
L + N L+ GV+ LC+ L
Sbjct: 345 ELQISNNRLEDAGVRELCQGL 365
Score = 169 bits (429), Expect = 1e-41
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
Query: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
Score = 150 bits (378), Expect = 8e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
Query: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 955 KILDLGENDLQDDGVKLLCEALK 977
+ LDL N L D G+ L E+++
Sbjct: 401 RELDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
Query: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
Query: 760 LTCKSVTPEWVLQDLIIALQ 779
L + ++D + AL+
Sbjct: 432 LVLYDIYWSEEMEDRLQALE 451
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 175 bits (443), Expect = 2e-43
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1012 NLNLLGNELDTDGVKMLCKAL 1032
L + N L+ GV+ LC+ L
Sbjct: 345 ELQISNNRLEDAGVRELCQGL 365
Score = 169 bits (429), Expect = 1e-41
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
Query: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
Score = 150 bits (378), Expect = 8e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
Query: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 955 KILDLGENDLQDDGVKLLCEALK 977
+ LDL N L D G+ L E+++
Sbjct: 401 RELDLSNNCLGDAGILQLVESVR 423
Score = 94.7 bits (234), Expect = 4e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
Query: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
Query: 760 LTCKSVTPEWVLQDLIIALQ 779
L + ++D + AL+
Sbjct: 432 LVLYDIYWSEEMEDRLQALE 451
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,380,513
Number of Sequences: 37866
Number of extensions: 1835561
Number of successful extensions: 7005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 5786
Number of HSP's gapped (non-prelim): 596
length of query: 1043
length of database: 18,247,518
effective HSP length: 112
effective length of query: 931
effective length of database: 14,006,526
effective search space: 13040075706
effective search space used: 13040075706
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.