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Search of human proteins with 110611170
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
(1095 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 2343 0.0
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 1282 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 579 e-165
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 573 e-163
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 543 e-154
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 541 e-153
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 527 e-149
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 525 e-149
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 453 e-127
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 446 e-125
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 441 e-123
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 431 e-120
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 428 e-119
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 426 e-119
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 407 e-113
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 400 e-111
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 370 e-102
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 345 2e-94
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 341 2e-93
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 341 2e-93
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 338 2e-92
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 320 4e-87
gi|145309328 papilin [Homo sapiens] 300 6e-81
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 247 4e-65
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 243 9e-64
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 226 1e-58
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 224 3e-58
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 202 1e-51
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 200 5e-51
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 181 3e-45
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 2343 bits (6072), Expect = 0.0
Identities = 1095/1095 (100%), Positives = 1095/1095 (100%)
Query: 1 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR 60
MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
Sbjct: 1 MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR 60
Query: 61 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR 120
RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
Sbjct: 61 RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR 120
Query: 121 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI 180
PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
Sbjct: 121 PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI 180
Query: 181 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA 240
RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
Sbjct: 181 RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA 240
Query: 241 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG 300
DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
Sbjct: 241 DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG 300
Query: 301 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI 360
ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
Sbjct: 301 ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI 360
Query: 361 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG 420
AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
Sbjct: 361 AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG 420
Query: 421 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF 480
RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
Sbjct: 421 RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF 480
Query: 481 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE 540
GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
Sbjct: 481 GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE 540
Query: 541 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG 600
HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
Sbjct: 541 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG 600
Query: 601 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP 660
LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
Sbjct: 601 LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP 660
Query: 661 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG 720
YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG
Sbjct: 661 YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG 720
Query: 721 SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY 780
SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY
Sbjct: 721 SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY 780
Query: 781 TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND 840
TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND
Sbjct: 781 TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND 840
Query: 841 SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT 900
SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT
Sbjct: 841 SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT 900
Query: 901 RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR 960
RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR
Sbjct: 901 RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR 960
Query: 961 PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY 1020
PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY
Sbjct: 961 PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY 1020
Query: 1021 RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC
Sbjct: 1021 RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
Query: 1081 RDFYANKMRQPPPNS 1095
RDFYANKMRQPPPNS
Sbjct: 1081 RDFYANKMRQPPPNS 1095
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 1282 bits (3317), Expect = 0.0
Identities = 592/1080 (54%), Positives = 761/1080 (70%), Gaps = 56/1080 (5%)
Query: 51 PPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVE 110
PP P P P +PP A A P +LL +PAF RDLYL LRRD RFL+ F VE
Sbjct: 142 PPPPPQPPP-------SPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVE 194
Query: 111 E-----------AGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQE 159
+ A A + P CFY+G VL HPGSL S S CG GGL+G IQL ++
Sbjct: 195 QRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG--GGLMGFIQLNED 252
Query: 160 QVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDW 219
+ I+PLN++ + R+K S+ + ++ C ++++K +P + +
Sbjct: 253 FIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESG 312
Query: 220 RERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINI 279
R +R + +L E+ +ET+VVAD MV YHGA+AA+RFILT++NMV+N+FQH+SL +++N+
Sbjct: 313 RGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNL 372
Query: 280 QVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
+V KL+LL + P +L IGHHGE+ LESFC WQ+EE+G + +D VDAA
Sbjct: 373 RVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAA 432
Query: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
+ +TR DFCVHKDEPCDTVGIAYL G+CS KRKC++AEDNGLNLAFTIAHE+GHN+G+NH
Sbjct: 433 ILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINH 492
Query: 400 DDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV 459
D+DH SCA HIMSGEW+KG+N D+SWS CS++DLE FL+SK S CLL T+P+S ++V
Sbjct: 493 DNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSV 552
Query: 460 RLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGT 519
+P KLPGM Y+A+EQCQILFG A+FC+ M+H++C GLWC VEG+ C+TKLDPP+DGT
Sbjct: 553 MVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGT 612
Query: 520 ECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGG 579
+C KWC+AGEC S+T PEH+ G+WS WS CSRTC G R+RKC P
Sbjct: 613 DCDLGKWCKAGECTSRTSAPEHLAGEWS---LWSPCSRTCSAGISSRERKC--PGLDSEA 667
Query: 580 THCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT--AVVVDDKPCELYC 637
C G ++ +CEN PCP GLP FRD QCQA+ + K +L AV+ ++KPC L+C
Sbjct: 668 RDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFC 727
Query: 638 SPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGK 697
SP+GKE P+L++++V+DGT CG D+C +G+CQK+GCDG++GS A+ED CGVC+G+GK
Sbjct: 728 SPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGK 787
Query: 698 TCHLVKGDFSHARGT---------------------------ALKDSGKGSINSDWKIEL 730
+C ++KGDF+H RG AL+D+GK SINSDWKIE
Sbjct: 788 SCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEH 847
Query: 731 PGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAEN 790
G F +AGTTV YVRRGLWEKISAKGPT PLHL+VLLF DQ+YG+HYEYT+P + EN
Sbjct: 848 SGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPEN 907
Query: 791 QSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE 850
QS K + LF+WTH+ WE C CGGGER+T VSCT+I++K ++V++ C ++PE
Sbjct: 908 QSS--KAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPE 965
Query: 851 PQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRP 910
PQ+R+CN PCQ+RW+ W+PCS TC KG Q R+V C QL NGT + R C GP+P
Sbjct: 966 PQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKP 1025
Query: 911 AAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDY 970
A+ Q CEGQDC+++WEA WS+CS CGKG+ RTV CTN + KC STRPR E CEDY
Sbjct: 1026 ASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDY 1085
Query: 971 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCND 1030
S CY W+ GDWS CS TCGKG+QSRV+QCMHK+TGRHG+EC + KPA YR C+ + CN+
Sbjct: 1086 SKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE 1145
Query: 1031 RINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQ 1090
+IN NTITSPRLAALT+KC DQW VYCRVIREKNLCQDMRWYQRCC+TCRDFYA K++Q
Sbjct: 1146 KINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQ 1205
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 579 bits (1492), Expect = e-165
Identities = 365/1027 (35%), Positives = 501/1027 (48%), Gaps = 117/1027 (11%)
Query: 9 PLVLPVLLLLVW------GLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRR 62
PL+ P+LLLL G PG A AA +++V P RV L P R+
Sbjct: 12 PLLRPLLLLLCALAPGAPGPAPGRATEGRAA-LDIVHPVRVDAGGSFLS-YELWPRALRK 69
Query: 63 RRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRG--- 119
R AP L GR+L L + L+ GF E RRRG
Sbjct: 70 RDVSVRRDAPA--------FYELQYRGRELRFNLTANQHLLAPGFVSE----TRRRGGLG 117
Query: 120 -------RPAELCFYSGRVLGHP--GSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQ 170
PA C G V G L ++SAC GL G+ QL E I+PL+++
Sbjct: 118 RAHIRAHTPA--CHLLGEVQDPELEGGLAAISACD---GLKGVFQLSNEDYFIEPLDSAP 172
Query: 171 G-PFSGREHLIRRKW----------SLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDW 219
P + H++ ++ S PS PE + +++ W RP
Sbjct: 173 ARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRR 232
Query: 220 RERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINI 279
+R+ ++ E VETLVVADA MV+YHG + ++LT+MNMV +F S+G I+I
Sbjct: 233 LHQRS---VSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHI 289
Query: 280 QVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
+ +LVLL L I HH + +L+SFC WQ G P D A
Sbjct: 290 TIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSIN-----------MKGDAHPLHHDTA 338
Query: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
+ +TR D C + PC+T+G++++ G+C R C + ED GL LAFT+AHELGH+ G+ H
Sbjct: 339 ILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQH 398
Query: 400 DDDHSSC---AGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQ 456
D + C R IMS + + P L+WS CSR + FL CL DP ++
Sbjct: 399 DGSGNDCEPVGKRPFIMSPQLLYDAAP--LTWSRCSRQYITRFLDRGWGLCL--DDPPAK 454
Query: 457 HTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPL 516
+ P PG+ Y + QC++ +G + FC +M+++ C LWC V T+C +KLD +
Sbjct: 455 DIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNV-CHTLWCSV--GTTCHSKLDAAV 511
Query: 517 DGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPG 576
DGT CG +KWC +GECV PE VDG WS W AWS+CSR+CG G + +R+C P P
Sbjct: 512 DGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPK 571
Query: 577 PGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD-KPCEL 635
G +C G +C CP G PSFR QC D + K + VV+D PCEL
Sbjct: 572 YKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCEL 631
Query: 636 YCSPLGKESPLLVADRVLDGTPCGPYET--DLCVHGKCQKIGCDGIIGSAAKEDRCGVCS 693
+C P + + D V+DGTPC DLC++G C+ +GCD I S A EDRCGVC
Sbjct: 632 HCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCH 691
Query: 694 GDGKTCHLVKGDFSHARGTALKDSG-----------------------------KGSINS 724
G+G TCH V G F A G D G K +N
Sbjct: 692 GNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNG 751
Query: 725 DWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPV 784
W I+ G++Q+AGTT Y RRG WE +++ GPTK P+ + LLF + + G+HYEYT +
Sbjct: 752 GWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEPVWIQ-LLFQESNPGVHYEYT--I 808
Query: 785 NRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCP 844
+R A E P +F W + W C+V CG G +R V C + + V++ C
Sbjct: 809 HREAGGHDEVPPP---VFSWHYGPWTKCTVTCGRGVQRQNVYC---LERQAGPVDEEHCD 862
Query: 845 QASRPEPQVRRCNLHPCQSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGTHVATRPL 903
RP+ Q R+C+ PC +RW AG W CS++C G R V C+ + A P
Sbjct: 863 PLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPP 922
Query: 904 YCPG-PRPAAVQSCEGQ-DCLSIWEASEWSQCSASCGKGVWKRTVACTNSQG-KCDASTR 960
C PRP C C + W WSQCS +CG+G +R V CTN G CD + +
Sbjct: 923 ACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQ 982
Query: 961 PRAEEAC 967
P +E C
Sbjct: 983 PASEVTC 989
Score = 155 bits (392), Expect = 2e-37
Identities = 101/303 (33%), Positives = 136/303 (44%), Gaps = 39/303 (12%)
Query: 788 AENQSEPEKPQDSLFI----WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC 843
A + +E P D L + W W CS CG G V C+ D DC
Sbjct: 1395 APSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSS--------GRDEDC 1446
Query: 844 PQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPL 903
A RP+P RRC+L PC + W +G WS CS +C G R+V CV RP
Sbjct: 1447 APAGRPQP-ARRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRDVQCV---DTRDLRPLRPF 1501
Query: 904 YC-PGP-RPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRP 961
+C PGP +P A + C Q CLS W S W +CS +CG G +R V C G C+ + RP
Sbjct: 1502 HCQPGPAKPPAHRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPEP-GLCEEALRP 1559
Query: 962 RAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTG---RHGSECPALSKPA 1018
C + C +W G W CS CG G+Q R+V+C++ TG +C + P
Sbjct: 1560 NTTRPCNTHP-CTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPE 1618
Query: 1019 PYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTV-YCRVIREKNLCQDMRWYQRCC 1077
R C E C + PR C RD+ + +C +R CQ +CC
Sbjct: 1619 SSRPCGTEDC------EPVEPPR-------CERDRLSFGFCETLRLLGRCQLPTIRTQCC 1665
Query: 1078 QTC 1080
++C
Sbjct: 1666 RSC 1668
Score = 96.3 bits (238), Expect = 1e-19
Identities = 63/178 (35%), Positives = 80/178 (44%), Gaps = 22/178 (12%)
Query: 865 WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC-PGPRPAAVQ-SCEGQDCL 922
W GPW+ C+ TC +G Q + V C+ + Q G +C P RP Q C Q C
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCL-ERQAGP---VDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 923 SIWEASEWSQCSASCGKG-VWKRTVACTNSQG----------KCDASTRPRAEEACEDYS 971
+ W A EW CS+SCG G + +R V C S G C+ RP E C +
Sbjct: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHV 940
Query: 972 GC-YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
C W G+WS CS TCG+G Q R V C T G C +PA C +C
Sbjct: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLC----TNDTGVPCDEAQQPASEVTCSLPLC 994
Score = 43.9 bits (102), Expect = 8e-04
Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE-CPALSKP-APYRQCYQEVCNDR 1031
+ W G W+ C+ TCG+G+Q + V C+ + G E C L +P R+C ++ C R
Sbjct: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPAR 882
Score = 43.1 bits (100), Expect = 0.001
Identities = 44/186 (23%), Positives = 68/186 (36%), Gaps = 37/186 (19%)
Query: 916 CEGQD--CLSIWEASEWSQCSAS---------CGKGVWKRTVACTNSQGKCDASTRPRAE 964
CE D C ++W S + C + CG+ W + C RP A
Sbjct: 485 CEDMDNVCHTLW-CSVGTTCHSKLDAAVDGTRCGENKWCLSGECV------PVGFRPEAV 537
Query: 965 EACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCY 1024
+ G W WS CS +CG G+QS QC G C + + +R C
Sbjct: 538 DG-----GWSGWSA--WSICSRSCGMGVQSAERQCTQPTPKYKGRYC--VGERKRFRLCN 588
Query: 1025 QEVC-NDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDF 1083
+ C R + + A+ YK W V+ + N C + C+ ++
Sbjct: 589 LQACPAGRPSFRHVQCSHFDAMLYKGQLHTWV---PVVNDVNPC------ELHCRPANEY 639
Query: 1084 YANKMR 1089
+A K+R
Sbjct: 640 FAEKLR 645
Score = 33.9 bits (76), Expect = 0.87
Identities = 21/55 (38%), Positives = 24/55 (43%), Gaps = 9/55 (16%)
Query: 550 GAWSMCSRTCGTGARFRQRKC----DNPPPGPGGTHC---PGASVEHAVCENLPC 597
G WS CSR+CG G+ R +C D P P HC P H C PC
Sbjct: 1469 GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRP--FHCQPGPAKPPAHRPCGAQPC 1521
Score = 33.5 bits (75), Expect = 1.1
Identities = 35/123 (28%), Positives = 44/123 (35%), Gaps = 18/123 (14%)
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
S W A WS CS +C G Q E C + YC G R + C Q C
Sbjct: 542 SGWSA--WSICSRSCGMGVQSAERQCTQPTPK-----YKGRYCVGER-KRFRLCNLQACP 593
Query: 923 SIWEASEWSQCS---ASCGKGVWKRTVACTNSQGKCDASTRPRAE-------EACEDYSG 972
+ + QCS A KG V N C+ RP E +A D +
Sbjct: 594 AGRPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTP 653
Query: 973 CYE 975
CY+
Sbjct: 654 CYQ 656
Score = 31.2 bits (69), Expect = 5.6
Identities = 12/23 (52%), Positives = 15/23 (65%)
Query: 550 GAWSMCSRTCGTGARFRQRKCDN 572
G WS CS TCG GA +R +C +
Sbjct: 1418 GNWSECSTTCGLGAVWRPVRCSS 1440
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 573 bits (1477), Expect = e-163
Identities = 367/1090 (33%), Positives = 510/1090 (46%), Gaps = 112/1090 (10%)
Query: 62 RRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRP 121
RRR P P+ + L L A+G+ +L L + F+S+ F VE G + +
Sbjct: 68 RRRRSMDPIDPQQAVSK--LFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKH 125
Query: 122 AEL--CFYSGRVLGHPGSL-VSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPF----- 173
L C Y+G + + V+LS C GL G+I E+ I+PL N+
Sbjct: 126 DFLDNCHYTGYLQDQRSTTKVALSNCV---GLHGVIATEDEEYFIEPLKNTTEDSKHFSY 182
Query: 174 -SGREHLIRRKWSLTPSPSAEAQRPEQLCKV--LTEKKKPTW---------GRPSRDWRE 221
+G H+I +K +L + C V T KP W P +
Sbjct: 183 ENGHPHVIYKKSALQQRHLYDHSH----CGVSDFTRSGKPWWLNDTSTVSYSLPINNTHI 238
Query: 222 RRNAIRLTS-EHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQ 280
R S E VETLVVAD MV YHG + + +IL+VMN+V +++ SLG +NI
Sbjct: 239 HHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNII 298
Query: 281 VTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAV 340
V +L++L + L I HH ++SL+SFC WQ + N +P ++ D AV
Sbjct: 299 VARLIVLTEDQPNLEINHHADKSLDSFCKWQKSIL--SHQSDGNTIP--ENGIAHHDNAV 354
Query: 341 FVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHD 400
+TR D C +K++PC T+G+A + G+C +R C + ED GL AFTIAHE+GHN GMNHD
Sbjct: 355 LITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHD 414
Query: 401 DDHSSCAGRSH----IMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQ 456
+SC + H +M+ NP SWS+CSRD + +FL S TCL P+
Sbjct: 415 GIGNSCGTKGHEAAKLMAAHITANTNP--FSWSACSRDYITSFLDSGRGTCLDNEPPKRD 472
Query: 457 HTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPL 516
P PG Y A+EQC+ +G + C+ E +C LWCL + + C T P
Sbjct: 473 FLY--PAVAPGQVYDADEQCRFQYGATSRQCKYGE--VCRELWCLSKSNR-CVTNSIPAA 527
Query: 517 DGTECGADK----WCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDN 572
+GT C WC G+CV P+ +DG W PW W CSRTCG G R CD+
Sbjct: 528 EGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDS 587
Query: 573 PPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD-- 630
P P GG +C G + C PCP G FR++QC D + + K
Sbjct: 588 PAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGV 647
Query: 631 KPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCG 690
KPC L C G A V+DGT C D+C++G+C+ +GCD I+GS A+EDRC
Sbjct: 648 KPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCR 707
Query: 691 VCSGDGKTCHLVKGDFSHA-------------RGT---------------ALKDSGKG-S 721
VC GDG TC ++G F+ + RG+ ALK G
Sbjct: 708 VCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYY 767
Query: 722 INSDWKIELPGEFQIAGTTVRYVR-RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY 780
IN W I+ P +F +AGT Y R E + A GPT L +MVLL +Q+ GI Y++
Sbjct: 768 INGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLL-QEQNLGIRYKF 826
Query: 781 TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND 840
VP+ RT +E F W H W CS C GG +R V C R+ ++V +
Sbjct: 827 NVPITRTGSGDNEVG------FTWNHQPWSECSATCAGGVQRQEVVCKRL--DDNSIVQN 878
Query: 841 SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT 900
+ C S+P R CN PC W G W CS TC+ G + R V C+ ++
Sbjct: 879 NYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETL 938
Query: 901 RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQ-------G 953
C RP + C Q C W A +WS+C+ CG G R V C +S
Sbjct: 939 DYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAA 998
Query: 954 KCDASTRPRAEEACEDYSGC--YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSEC 1011
+C ++P C C W TGDW CS+ CG G Q R VQC+ TG+ S+C
Sbjct: 999 QCPEESKPPVRIRC-SLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCL-SYTGQASSDC 1056
Query: 1012 PALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMR 1071
+P +QC + C+ +N T +C YC ++ + C
Sbjct: 1057 LETVRPPSMQQC-ESKCDSTPISN----------TEECKDVNKVAYCPLVLKFKFCSRAY 1105
Query: 1072 WYQRCCQTCR 1081
+ Q CC+TC+
Sbjct: 1106 FRQMCCKTCQ 1115
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 543 bits (1399), Expect = e-154
Identities = 360/1066 (33%), Positives = 496/1066 (46%), Gaps = 150/1066 (14%)
Query: 74 ARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVE---EAGAARRRGRPAELCFYSGR 130
A+ +L AFG++L+L+L+ LS F V+ + GA+ + + CFY G
Sbjct: 90 AQNARSSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGASETQKPEVQQCFYQGF 148
Query: 131 VLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPL-------NNSQGPFSGREHLIRRK 183
+ S V++S C GL GLI+ + + LI PL +N P H++ ++
Sbjct: 149 IRNDSSSSVAVSTCA---GLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKR 205
Query: 184 ---------------------WSLTPSPSAEAQRPEQLCKVLTEK-------KKPTWGRP 215
+S + P A R + +K KK P
Sbjct: 206 TAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPP 265
Query: 216 SRDW-----------RERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMV 264
+ D R RR+A + VETLVVAD MV+ HG +ILTVMNMV
Sbjct: 266 TEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMV 325
Query: 265 YNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYG--GARYLG 322
+F+ ++G IN+ V L+LL Q P L I HH ++SL SFC WQ+ G G R+
Sbjct: 326 SGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRH-- 383
Query: 323 NNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLN 382
D A+ +T D C K+EPCDT+G A + G+CS R C + ED GL
Sbjct: 384 --------------DHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLG 429
Query: 383 LAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKS 442
LAFTIAHE GHN GM HD + + C + + G N SWSSCSR L+ FL +
Sbjct: 430 LAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNN-GVFSWSSCSRQYLKKFLST 488
Query: 443 KVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHLMCAGLWCL 501
+ C LV +P+ + P KLPG Y A+ QC+ FG A C +C LWC
Sbjct: 489 PQAGC-LVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCH 547
Query: 502 VEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPI-PEHVDGDWSPWGAWSMCSRTCG 560
G C+TK P +GT CG WCR G+CV + P + G WS W WS CSRTCG
Sbjct: 548 RVGH-RCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCG 606
Query: 561 TGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKK 620
G +F++R C+NP P GG CPG+S + +C PC + FR QQC ++ S +
Sbjct: 607 GGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN--SKPFR 664
Query: 621 GLL------TAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKI 674
G T V +D+ C+LYC E ++ +V DGTPC P + D+C+ G C+ +
Sbjct: 665 GWFYQWKPYTKVEEEDR-CKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELV 723
Query: 675 GCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF----------------SHARGTALKD-- 716
GCD +GS A D CGVC GD TC KG + + AR +++
Sbjct: 724 GCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQ 783
Query: 717 -----------SGKGSINSDWKIELPGEFQIAGTTVRYVRR-GLWEKISAKGPTKLPLHL 764
S K + W I+ PGEF AGTT Y R E++ A GPT L +
Sbjct: 784 VSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETL-V 842
Query: 765 MVLLFHDQDYGIHYEYTVP--VNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERR 822
+L ++ GI ++Y +P +N T P + + W+ E CSV CGGG
Sbjct: 843 FEILMQGKNPGIAWKYALPKVMNGT------PPATKRPAYTWSIVQSE-CSVSCGGGYIN 895
Query: 823 TIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQ 882
C R N T VN S C ++P + + CN C + W+ G WS CS C G Q
Sbjct: 896 VKAICLRDQN---TQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQ 952
Query: 883 HREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVW 942
R++ CV + A CP P VQ+C C W WSQCS +CG+GV
Sbjct: 953 SRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVR 1012
Query: 943 KRTVACTNS------QGKCDASTRPRAEEACE----DYSGCYEWKTGDWSTCSSTCGKGL 992
KR + C S + +C + RP +E C + +W WS CS+TCG G+
Sbjct: 1013 KRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGV 1072
Query: 993 QSRVVQCMHKVTGRHGS-------ECPALSKPAPYRQCYQEVCNDR 1031
+ R ++C K G G C + KP +E CN R
Sbjct: 1073 RKREMKCSEK--GFQGKLITFPERRCRNIKKP---NLDLEETCNRR 1113
Score = 129 bits (324), Expect = 2e-29
Identities = 92/304 (30%), Positives = 128/304 (42%), Gaps = 48/304 (15%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVN-KTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
W W CS C GG++ + C + + V S CP ++ QV+ CN H C
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST--PTQVQACNSHACP 992
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRP-LYCPG-PRPAAVQSCEGQD 920
+W GPWS CS TC +G + RE+ C G+ T P C PRP + C
Sbjct: 993 PQWSLGPWSQCSKTCGRGVRKRELLC-----KGSAAETLPESQCTSLPRPELQEGCVLGR 1047
Query: 921 CLSI----WEASEWSQCSASCGKGVWKRTVACTNS--QGK--------CDASTRPRA--E 964
C W AS WS+CSA+CG GV KR + C+ QGK C +P E
Sbjct: 1048 CPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLE 1107
Query: 965 EACED--------YSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSK 1016
E C Y+ W + W C+ TCG G+Q+R V C+ + GR S C K
Sbjct: 1108 ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ--GRPSSSCLLHQK 1165
Query: 1017 PAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRC 1076
P R C N N +P W C ++ + +C + ++C
Sbjct: 1166 PPVLRAC---------NTNFCPAPEKREDPSCVDFFNW---CHLVPQHGVCNHKFYGKQC 1213
Query: 1077 CQTC 1080
C++C
Sbjct: 1214 CKSC 1217
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/141 (27%), Positives = 53/141 (37%), Gaps = 22/141 (15%)
Query: 797 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTR--IVNKTTTLVNDSDCPQASRPEPQV- 853
P++S W S W CS CG G R+ + C+ K T + C +P +
Sbjct: 1049 PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFP-ERRCRNIKKPNLDLE 1107
Query: 854 -----RRCNLHPCQSR---WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV------- 898
R C HP + W + PW C+ TC G Q R V CV Q + +
Sbjct: 1108 ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPP 1167
Query: 899 ---ATRPLYCPGPRPAAVQSC 916
A +CP P SC
Sbjct: 1168 VLRACNTNFCPAPEKREDPSC 1188
Score = 36.6 bits (83), Expect = 0.13
Identities = 41/163 (25%), Positives = 60/163 (36%), Gaps = 35/163 (21%)
Query: 921 CLSIWEASEWSQCSAS---------CGKGVWKRTVACTNSQGKCD--ASTRPRAEEACED 969
C S+W +C CG +W R QG+C PR
Sbjct: 541 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCR-------QGQCVKFGELGPRPIHG--- 590
Query: 970 YSGCYEWKT-GDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
+W WS CS TCG G++ + C + G CP S+ Y+ C C
Sbjct: 591 -----QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINPC 643
Query: 1029 NDRINANTITSPRLAALTYKCTRD---QWTVYCRVIREKNLCQ 1068
N+ N+ + + A K R QW Y +V E++ C+
Sbjct: 644 NE--NSLDFRAQQCAEYNSKPFRGWFYQWKPYTKV-EEEDRCK 683
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 541 bits (1395), Expect = e-153
Identities = 373/1121 (33%), Positives = 517/1121 (46%), Gaps = 134/1121 (11%)
Query: 36 EVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQ 95
E+ P RV + L P P PRR+RR A R L + + L
Sbjct: 40 EIAFPTRVDHNGALLAFSP--PPPRRQRRGTGATAESR-------LFYKVASPSTHFLLN 90
Query: 96 LRRDLRFLSRGFEVE----EAGAARRRGRPAELCFYSGRVLGHPG-SLVSLSACGAAGGL 150
L R R L+ VE E A +R RP C Y+G + G S V++S CG GL
Sbjct: 91 LTRSSRLLAGHVSVEYWTREGLAWQRAARPH--CLYAGHLQGQASTSHVAISTCG---GL 145
Query: 151 VGLIQLGQEQVLIQPLNN----SQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTE 206
GLI +E+ LI+PL+ S+ P H++ ++ SL + C V E
Sbjct: 146 HGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSL------RHPHLDTACGVRDE 199
Query: 207 KK-----------KPTWGRPSRDWRERRNA---IRLTSEHTVETLVVADADMVQYHGAEA 252
K KP RP + ER ++ E VETLVVAD MV YHG
Sbjct: 200 KPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRD 259
Query: 253 AQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQN 312
++++L +MN+V +FQ SLG +NI VT+L+LL + L I HH +SL+SFC WQ
Sbjct: 260 VEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQK 319
Query: 313 EEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRK 372
+ + N +P ++ D AV +TR D C++K++PC T+G+A +GG+C +R
Sbjct: 320 SIVNHSGH--GNAIP--ENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERS 375
Query: 373 CVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSH----IMSGEWVKGRNPSDLSW 428
C + ED GL AFTIAHE+GH GMNHD +SC R +M+ NP W
Sbjct: 376 CSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNP--FVW 433
Query: 429 SSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR 488
SSCSRD + +FL S + CL PR P PG Y A+EQC+ G+ + C+
Sbjct: 434 SSCSRDYITSFLDSGLGLCLNNRPPRQDFVY--PTVAPGQAYDADEQCRFQHGVKSRQCK 491
Query: 489 NMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGA---DK-WCRAGECVSKTPIPEHVDG 544
E +C+ LWCL + + C T P +GT C DK WC CV PE VDG
Sbjct: 492 YGE--VCSELWCLSKSNR-CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDG 548
Query: 545 DWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSF 604
W PW W CSRTCG G R CD+P P GG +C G H C CP G F
Sbjct: 549 AWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDF 608
Query: 605 RDQQCQAHDRLSPKKKGLLTAVVVDD--KPCELYCSPLGKESPLLVADRVLDGTPCGPYE 662
R+ QC D + + K K C L C G A V+DGTPC P
Sbjct: 609 REVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDT 668
Query: 663 TDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHAR-GTALKDS---G 718
D+CV G+C+ +GCD ++GS +ED+C VC GDG C ++G FS A G +D
Sbjct: 669 VDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIP 728
Query: 719 KGSIN---SDWKIEL----------------------PGEFQIAGTTVRYVRRG--LWEK 751
KGS++ D + L P +AGTT + +R+G +
Sbjct: 729 KGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQ-LRQGPDQVQS 787
Query: 752 ISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSL--FIWTHSGW 809
+ A GP L +MVL + + Y + P+ R DSL + W ++ W
Sbjct: 788 LEALGPINASLIVMVLARTELP-ALRYRFNAPIAR------------DSLPPYSWHYAPW 834
Query: 810 EGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGP 869
CS QC GG + V C ++ + V C S+ + R CN PC WV G
Sbjct: 835 TKCSAQCAGGSQVQAVECRNQLDSSA--VAPHYCSAHSKLPKRQRACNTEPCPPDWVVGN 892
Query: 870 WSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASE 929
WS CS +C+ G + R V C ++ A CP PRP +++C G C W A +
Sbjct: 893 WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALD 952
Query: 930 WSQCSASCGKGVWKRTVACTNSQGK-------CDASTRPRAEEACEDYSGC--YEWKTGD 980
WS+C+ SCG G+ R V C ++ + C + +P A C + C W G+
Sbjct: 953 WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC-NLRRCPPARWVAGE 1011
Query: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSP 1040
W CS+ CG G + R V+C TG+ EC +P +QC + C+ SP
Sbjct: 1012 WGECSAQCGVGQRQRSVRCTSH-TGQASHECTEALRPPTTQQC-EAKCD---------SP 1060
Query: 1041 RLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCR 1081
+C YC ++ + C + Q CC+TC+
Sbjct: 1061 TPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 527 bits (1357), Expect = e-149
Identities = 324/928 (34%), Positives = 460/928 (49%), Gaps = 86/928 (9%)
Query: 90 RDLYLQLRRDLRFLSRGFEVEEA----GAARRRGRPAELCFYSGRVLGHPGSLVSLSACG 145
+DL+ L + FLS + +E+ + A LC SG VL G+ V +A
Sbjct: 100 KDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVL-QQGTRVGTAALS 158
Query: 146 AAGGLVGLIQLGQEQVLIQPLNNSQGPFSG-REHLIRRKWSL--TPSPSAEAQRPEQLCK 202
A GL G QL I+P+ G H++ R+ + T P+ + + +
Sbjct: 159 ACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQ 218
Query: 203 VLTEKKKPTWGR---PSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILT 259
E + W R PSR R ++ E VETLVVAD M++YHG+E + +ILT
Sbjct: 219 K-QELWREKWERHNLPSRSLSRRS----ISKERWVETLVVADTKMIEYHGSENVESYILT 273
Query: 260 VMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGAR 319
+MNMV +F + S+G I+I V +L+LL + L I HH E++L SFC WQ
Sbjct: 274 IMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSIN---- 329
Query: 320 YLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDN 379
P +P D AV +TR D C + PC+T+G+++L G+C R C + ED+
Sbjct: 330 -------PKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDS 382
Query: 380 GLNLAFTIAHELGHNLGMNHDDDHSSC--AGRS-HIMSGEWVKGRNPSDLSWSSCSRDDL 436
GL LAFTIAHELGH+ G+ HD + C GR +IMS + +P+ L+WS CS + +
Sbjct: 383 GLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQY--DPTPLTWSKCSEEYI 440
Query: 437 ENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCA 496
FL CL D + ++ PG+ Y + QCQ+ +G NATFC+ +E++ C
Sbjct: 441 TRFLDRGWGFCL--DDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENV-CQ 497
Query: 497 GLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCS 556
LWC V+G C++KLD DGT+CG KWC AG+C++ PE + G W W WS CS
Sbjct: 498 TLWCSVKG--FCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCS 555
Query: 557 RTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLS 616
RTCG G + +R C+NP P GG +C G + +C PC P+FR QC D +
Sbjct: 556 RTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTV- 614
Query: 617 PKKKGLL--TAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPC--GPYETDLCVHGKCQ 672
P K L + PCELYC P+ + + D V+DGTPC G ++C++G C+
Sbjct: 615 PYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICK 674
Query: 673 KIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSG---KGS-------- 721
+GCD I S A EDRCGVC GDG +C V+ F G+ D G KG+
Sbjct: 675 MVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEI 734
Query: 722 ------------------INSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLH 763
+N + I+ G +++AGT +Y R+G EK+ A GPT +
Sbjct: 735 EGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVW 794
Query: 764 LMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRT 823
+ LLF + GI YEYT+ + + ++ W + W CSV CG G RR
Sbjct: 795 IQ-LLFQVTNPGIKYEYTI------QKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQ 847
Query: 824 IVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATC-EKGFQ 882
C + K +V + C ++P + ++C+ C RW AG W CSATC G +
Sbjct: 848 TAHC---IKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEK 904
Query: 883 HREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEGQD-CLSIWEASEWSQCSASCGKG 940
R V C+ Q A P C +P + SC C S W WS+CS SCG G
Sbjct: 905 KRTVLCI-QTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGG 963
Query: 941 VWKRTVACT-NSQGKCDASTRPRAEEAC 967
V R+V C N CD + +P + C
Sbjct: 964 VRIRSVTCAKNHDEPCDVTRKPNSRALC 991
Score = 160 bits (405), Expect = 6e-39
Identities = 92/285 (32%), Positives = 130/285 (45%), Gaps = 38/285 (13%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
W W CS CG G V C+ + DSDC RP+P +RC+L PC
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM--------DSDCAAIQRPDP-AKRCHLRPCAG 1367
Query: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP---GPRPAAVQSCEGQD 920
W G WS CS C GF+ RE+ CV + H RP +C G P SC +
Sbjct: 1368 -WKVGNWSKCSRNCSGGFKIREIQCV---DSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGD 980
C W+ WSQCS SCG GV +R V C G CD + RP + +C ++ C+ W TG+
Sbjct: 1424 C-EAWQVEPWSQCSRSCGGGVQERGVFCPG--GLCDWTKRPTSTMSCNEHLCCH-WATGN 1479
Query: 981 WSTCSSTCGKGLQSRVVQCM----HKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANT 1036
W CS++CG G Q R VQC+ +K + C +P +++C Q+ C
Sbjct: 1480 WDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK------- 1532
Query: 1037 ITSPRLAALTYKCTRDQWTV-YCRVIREKNLCQDMRWYQRCCQTC 1080
+ CT+D+ + +C+ ++ C CC +C
Sbjct: 1533 ------KSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 81.6 bits (200), Expect = 4e-15
Identities = 52/176 (29%), Positives = 71/176 (40%), Gaps = 19/176 (10%)
Query: 865 WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQS-CEGQDCLS 923
W G W+ CS TC G + + C+ + G + P +P Q C + C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCI---KKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 924 IWEASEWSQCSASCGK-GVWKRTVACTNSQGK---------CDASTRPRAEEACEDYSGC 973
W A EW CSA+CG G KRTV C + C +P+ +C C
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
Query: 974 -YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
+W G+WS CS +CG G++ R V C H C KP C + C
Sbjct: 945 PSDWTVGNWSECSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRALCGLQQC 996
Score = 49.3 bits (116), Expect = 2e-05
Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 4/57 (7%)
Query: 972 GCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
G W G+WS CS+TCG G R V+C ++ S+C A+ +P P ++C+ C
Sbjct: 1313 GSAHWIVGNWSECSTTCGLGAYWRRVECSTQM----DSDCAAIQRPDPAKRCHLRPC 1365
Score = 41.2 bits (95), Expect = 0.005
Identities = 18/60 (30%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR-HGSECPALSKP-APYRQCYQEVCNDR 1031
Y W+ G W+ CS TCG G++ + C+ K G + C ++P ++C+++ C R
Sbjct: 826 YFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR 885
Score = 34.3 bits (77), Expect = 0.66
Identities = 50/201 (24%), Positives = 72/201 (35%), Gaps = 36/201 (17%)
Query: 427 SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATF 486
+WS CSR+ F K + C+ D R +R H CQ L G+
Sbjct: 1372 NWSKCSRNCSGGF-KIREIQCV---DSRDHRNLRPFH------------CQFLAGIPPPL 1415
Query: 487 CRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGEC------VSKTPIPE 540
+ C W VE + C + E G +C G C S E
Sbjct: 1416 SMSCNPEPCEA-W-QVEPWSQCSRSCGGGVQ--ERGV--FCPGGLCDWTKRPTSTMSCNE 1469
Query: 541 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG 600
H+ W+ G W +CS +CG G + R +C P G + +C++ P P
Sbjct: 1470 HLCCHWAT-GNWDLCSTSCGGGFQKRTVQC---VPSEGN---KTEDQDQCLCDHKPRPPE 1522
Query: 601 LPSFRDQQC-QAHDRLSPKKK 620
Q C ++ D L K K
Sbjct: 1523 FKKCNQQACKKSADLLCTKDK 1543
Score = 31.6 bits (70), Expect = 4.3
Identities = 12/21 (57%), Positives = 15/21 (71%)
Query: 550 GAWSMCSRTCGTGARFRQRKC 570
G WS CS TCG GA +R+ +C
Sbjct: 1320 GNWSECSTTCGLGAYWRRVEC 1340
Score = 31.2 bits (69), Expect = 5.6
Identities = 18/48 (37%), Positives = 20/48 (41%), Gaps = 2/48 (4%)
Query: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
WS CS TCG G+QS C + G C K YR C C
Sbjct: 551 WSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPC 596
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 525 bits (1353), Expect = e-149
Identities = 346/1052 (32%), Positives = 491/1052 (46%), Gaps = 142/1052 (13%)
Query: 73 RARPGERALLLHLPAFG--RDLYLQLRRDLRFLSRGFEVEEAGAARRRG----RPAELCF 126
RA P LHL G D ++ LR ++ GF V+ G + P + CF
Sbjct: 87 RAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCF 146
Query: 127 YSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNN---------SQG------ 171
Y G + H S V+LS C GL G+I+ + ++PL + +QG
Sbjct: 147 YQGSLRSHRNSSVALSTCQ---GLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHV 203
Query: 172 ----------PFSGREHLIRRKWSLTPSP--SAEAQRPEQLCKVLTEKKKPTWGRPSRD- 218
P + + R W L P S++ + + ++K +P ++
Sbjct: 204 LYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKED 263
Query: 219 -----------WRERRNAIRL--TSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVY 265
R +R+ +R E VETLVV D M+Q HG E ++LT++NMV
Sbjct: 264 LFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVS 323
Query: 266 NMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYG--GARYLGN 323
+F+ ++G INI + L+LL L I HH + +L SFC WQ+ G G R+
Sbjct: 324 ALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRH--- 380
Query: 324 NQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNL 383
D A+ +T D C K+EPCDT+G A + G+CS R C + ED GL L
Sbjct: 381 -------------DHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGL 427
Query: 384 AFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSK 443
AFTIAHE GHN GM HD + + C + + GRN SWS CSR L FL +
Sbjct: 428 AFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRN-GVFSWSPCSRQYLHKFLSTA 486
Query: 444 VSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHLMCAGLWCLV 502
+ C L P+ + P KLPG Y AN QC+ FG A C + + +C LWC
Sbjct: 487 QAIC-LADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHR 545
Query: 503 EGDTSCKTKLDPPLDGTECGADKWCRAGECV---SKTPIPEHVDGDWSPWGAWSMCSRTC 559
G C+TK P +GT CG D WCR G+CV + P P H G WS W +WS CSRTC
Sbjct: 546 IG-RKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTH--GHWSDWSSWSPCSRTC 602
Query: 560 GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD--RLSP 617
G G R R C NP P GG C G++ +C + CP+ FR QC H+ R
Sbjct: 603 GGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRG 662
Query: 618 KKKGLLTAVVVDDKP-CELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGC 676
+ V+D+ C+LYC G + ++++V DGTPC ++C+ G C+++GC
Sbjct: 663 RHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGC 722
Query: 677 DGIIGSAAKEDRCGVCSGDGKTCHLVKGDF----------------SHARGTALKDSGKG 720
D ++GS A ED CGVC+G+ C + +G + S AR + +
Sbjct: 723 DNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVS 782
Query: 721 S-------------INSDWKIELPGEFQIAGTTVRYVRR-GLWEKISAKGPTKLPLHLMV 766
+ +N W ++ PG ++ +GTT Y R E + A GPT L ++
Sbjct: 783 TSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETL-IVE 841
Query: 767 LLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVS 826
LLF ++ G+ +EY++P R + P +P + W E CSV CGGG+
Sbjct: 842 LLFQGRNPGVAWEYSMP--RLGTEKQPPAQPS---YTWAIVRSE-CSVSCGGGQMTVREG 895
Query: 827 CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREV 886
C R + VN S C +RP + C + C W G WS CS TC G Q R V
Sbjct: 896 CYRDLK---FQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPV 952
Query: 887 TCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTV 946
C ++ + L CP P P++ Q+C Q C W A W++CS +CGKG KR V
Sbjct: 953 QCTRRVHYDSEPVPASL-CPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAV 1011
Query: 947 AC--TNSQGK--------CDASTRPRAEEACEDYSGCY-----EWKTGDWSTCSSTCGKG 991
AC TN + C + +PR EAC C+ +W WS CS TC +G
Sbjct: 1012 ACKSTNPSARAQLLPDAVCTSEPKPRMHEACL-LQRCHKPKKLQWLVSAWSQCSVTCERG 1070
Query: 992 LQSRVVQCMHK-VTGRH----GSECPALSKPA 1018
Q R ++C K V+G++ +C L KP+
Sbjct: 1071 TQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Score = 132 bits (333), Expect = 1e-30
Identities = 92/312 (29%), Positives = 129/312 (41%), Gaps = 58/312 (18%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRR-CNLHPCQ 862
W+ W CS CGGG + V CTR V+ + V S CPQ P P R+ CN C
Sbjct: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ---PAPSSRQACNSQSCP 987
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG------PRPAAVQSC 916
W AGPW+ CS TC KG++ R V C T+ + R P P+P ++C
Sbjct: 988 PAWSAGPWAECSHTCGKGWRKRAVAC-----KSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 917 EGQDCLSI----WEASEWSQCSASCGKGVWKRTVACTN----------SQGKCDASTRP- 961
Q C W S WSQCS +C +G KR + C + KC +P
Sbjct: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Query: 962 -RAEEACEDYS------------GCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHG 1008
E AC W WS C+++CG G+Q+R VQC+ GR
Sbjct: 1103 LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL--AGGRPA 1160
Query: 1009 SECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQ 1068
S C KP+ C C +A +D + +C ++ + +C
Sbjct: 1161 SGCLLHQKPSASLACNTHFC------------PIAEKKDAFCKDYFH-WCYLVPQHGMCS 1207
Query: 1069 DMRWYQRCCQTC 1080
+ ++CC+TC
Sbjct: 1208 HKFYGKQCCKTC 1219
Score = 35.8 bits (81), Expect = 0.23
Identities = 53/253 (20%), Positives = 85/253 (33%), Gaps = 45/253 (17%)
Query: 870 WSPCSAT-CEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEAS 928
WSPCS K + C+ P PG A C+ W+
Sbjct: 471 WSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCK-------WQFG 523
Query: 929 EWSQ-CSASCGKGVWKRTVACTNSQGKCDASTRPRAEEA------------CEDYSG--- 972
E ++ C K + K + C KC+ P AE C Y
Sbjct: 524 EKAKLCMLDFKKDICK-ALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGP 582
Query: 973 ------CYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQE 1026
+W + WS CS TCG G+ R C + G C ++ + C +
Sbjct: 583 KPTHGHWSDWSS--WSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQ 638
Query: 1027 VC-NDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFY- 1084
C D ++ + ++ +W Y +V +++LC+ C DF+
Sbjct: 639 KCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQV-EDQDLCK-----LYCIAEGFDFFF 692
Query: 1085 --ANKMRQPPPNS 1095
+NK++ P S
Sbjct: 693 SLSNKVKDGTPCS 705
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 453 bits (1166), Expect = e-127
Identities = 321/1040 (30%), Positives = 462/1040 (44%), Gaps = 144/1040 (13%)
Query: 87 AFGRDLYLQLRRDLRFLSRGFE-----VEEAGAARRRGRPAEL--CFYSGRVLGHPGSLV 139
A+G+ L L D FL+ G+ E GA P++L CFY G+V
Sbjct: 84 AYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKA 143
Query: 140 SLSACGAAGGLVGLIQLGQEQVLIQPLNNSQG----PFSGREHLIRRK------------ 183
+S CG GL G + + ++P+ + G + HLI R+
Sbjct: 144 VVSLCG---GLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKY 200
Query: 184 WSLTPSPSAEAQRP----EQLCKVLTEKKKPTWGR-----PSRDWRERRNAIRLTS-EHT 233
S++ S E P + + L K+ G P +D R RL S
Sbjct: 201 CSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRY 260
Query: 234 VETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAK 293
+E +V ADA +V HG+ Q +ILT+M++V +++ S+G I+I V KLV++ +
Sbjct: 261 IEIMVTADAKVVSAHGSNL-QNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEG 319
Query: 294 LSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDD--PPLVDAAVFVTRTDFCVHK 351
I G +L++FC WQ Q DD P D AV +TR D C K
Sbjct: 320 PVINFDGATTLKNFCSWQ-------------QTQNDLDDVHPSHHDTAVLITREDICSSK 366
Query: 352 DEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDD---HSSCAG 408
E C+ +G++YLG +C + C + E+ GL AFTIAHELGH LG+ HDD+
Sbjct: 367 -EKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVT 425
Query: 409 RSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGM 468
+ H+M+ +P SWS+CSR + FL + CLL D + LP +LPG
Sbjct: 426 KYHVMAPALSFHMSP--WSWSNCSRKYVTEFLDTGYGECLL--DKPDEEIYNLPSELPGS 481
Query: 469 HYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDT--SCKTKLDPPLDGTECGADKW 526
Y N+QC++ FG + C ++ +C LWC C T+ PP DGT+CG
Sbjct: 482 RYDGNKQCELAFGPGSQMCPHIN--ICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMH 539
Query: 527 CRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGAS 586
CR G CV+K V+G+W PW +S CSRTCG G R+C+ P P GG +C G
Sbjct: 540 CRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRR 599
Query: 587 VEHAVCENLPCPKGLPSFRDQQCQ-------------AHDRLSPKKKGLLTAVVVDDKPC 633
++ C CPKG FR++QC ++ R P+ G+ T C
Sbjct: 600 MKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGT-----KDRC 654
Query: 634 ELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCS 693
+LYC G L+ D V DGTPCG D+CV G+C GCD ++ S+AK D+CGVC
Sbjct: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
Query: 694 GDGKTCHLVKGDF--SHARGTALKDSGKGSINSDWK---------------IELPGEFQI 736
GD +C + G F SH + G+ N D + + G F
Sbjct: 715 GDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLF 774
Query: 737 AG-----------------TTVRYV-RRGLWEKISAKGPTKLPLHLMVLLFHD-QDYGIH 777
G T + Y E+I++ + L L VL + + +H
Sbjct: 775 NGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVH 834
Query: 778 YEYTVPVNRTAENQSEPEKPQDSLFIWTHSG-WEGCSVQCGGGERRTIVSCTRIVNKTTT 836
Y + +P+ ++ +F W G WEGC+ C G +RR I T I +
Sbjct: 835 YSFNIPLEERSD-----------MFTWDPYGPWEGCTKMCQGLQRRNI---TCIHKSDHS 880
Query: 837 LVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCV-YQLQNG 895
+V+D +C P + CN C+ RW S CS+ C +G++ ++ C+ Y + G
Sbjct: 881 VVSDKECDHLPLPSFVTQSCNT-DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEG 939
Query: 896 THVATRPLYCPGP-RPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQG- 953
V YC +P + C G + W SEWSQCS SCG G R C N+ G
Sbjct: 940 QTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGH 999
Query: 954 -----KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHG 1008
+C +R E C ++S C W +WS C TCGKG + R V C V
Sbjct: 1000 RLADNECQELSRV-TRENCNEFS-CPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSD 1057
Query: 1009 SECPALSKPAPYRQCYQEVC 1028
C + +KP C C
Sbjct: 1058 GFCNSSTKPESLSPCELHTC 1077
Score = 130 bits (328), Expect = 5e-30
Identities = 83/265 (31%), Positives = 118/265 (44%), Gaps = 37/265 (13%)
Query: 787 TAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQA 846
T EN +E P W S W C V CG G ++ V C V+ ++D C +
Sbjct: 1013 TRENCNEFSCPS-----WAASEWSECLVTCGKGTKQRQVWCQLNVDH----LSDGFCNSS 1063
Query: 847 SRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC- 905
++PE + C LH C S W GPW PC+ TC G+Q R+V CV +L + T C
Sbjct: 1064 TKPE-SLSPCELHTCAS-WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTE---CH 1118
Query: 906 PGPRPAAVQSCEGQDCLSI------------------WEASEWSQCSASCGKGVWKRTVA 947
RP+ QSC C I W W+ CS SCG+G R V+
Sbjct: 1119 EASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVS 1178
Query: 948 CTNSQGKCDASTR----PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKV 1003
C ++ + + PR E + ++ C EW+ GDWS CS++CG G +R V CM+
Sbjct: 1179 CRDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH 1238
Query: 1004 TGRHGSECPALSKPAPYRQCYQEVC 1028
+ C +P ++C C
Sbjct: 1239 QPIDENYCDPEVRPLMEQECSLAAC 1263
Score = 128 bits (321), Expect = 3e-29
Identities = 144/603 (23%), Positives = 217/603 (35%), Gaps = 110/603 (18%)
Query: 549 WGAWSMCSRTCGTGARFRQRKC-DNPPPGPGGTHCPGAS-VEHAVCENLPCPKGLPSFRD 606
+ WS CSR+CG G R R+ C +N C S V C CP S
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAAS-EW 1030
Query: 607 QQCQAHDRLSPKKKGLLTAVVVDD---------------KPCELY-CSP--LGKESPLL- 647
+C K++ + + VD PCEL+ C+ +G P
Sbjct: 1031 SECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTT 1090
Query: 648 ----------------VADRVLDGTPCG----PYETDLCVHGKCQKIGC--DGIIGSAAK 685
+A VL+ T C P + CV C I ++ +
Sbjct: 1091 TCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLI 1150
Query: 686 EDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQI--AGTTVRY 743
+ G C + G + AR + +D+ + + LP +I T
Sbjct: 1151 KKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCGE 1210
Query: 744 VRRGLWEKISAK-GPTKLPLHLMVLLFH---DQDY------------------------- 774
+ G W SA G K ++ + +H D++Y
Sbjct: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHF 1270
Query: 775 -------GIHYEYTVPVNRTAE-NQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVS 826
+ +P+ + E N+++ P W W CS C GG + V
Sbjct: 1271 PSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVV 1330
Query: 827 CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREV 886
C ++ S C AS+P P++++C PC +W G W CS TC G + R V
Sbjct: 1331 CQDENGQSA-----SYCDAASKP-PELQQCGPGPCP-QWNYGNWGECSQTCGGGIKSRLV 1383
Query: 887 TCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLS--IWEASEWSQCSASCGKGVWKR 944
C Q NG + P+ +Q C C + W W+ CSASCGKG R
Sbjct: 1384 IC--QFPNGQILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440
Query: 945 TVACTNS------QGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQ 998
V C + C +P +AC C WK W+ CS TCG G+Q R V
Sbjct: 1441 EVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVR-CPSWKANSWNECSVTCGSGVQQRDVY 1499
Query: 999 CMHKVTGRHGSE-CPALSKPAPYRQCYQEVC-------NDRINANTITSPRLAALTYKCT 1050
C K G+ E C ++P R+C+ + C R+N +T + + +CT
Sbjct: 1500 CRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT 1559
Query: 1051 RDQ 1053
+Q
Sbjct: 1560 DNQ 1562
Score = 87.4 bits (215), Expect = 7e-17
Identities = 67/241 (27%), Positives = 95/241 (39%), Gaps = 24/241 (9%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC-Q 862
W + W CSV CG G ++ V C K V + C Q++RP Q RRC C Q
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRL---KGVGQVVEEMCDQSTRPCSQ-RRCWSQDCVQ 1532
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
+ + CS +CE+ H+ + C N +Y ++C C
Sbjct: 1533 HKGMERGRLNCSTSCERKDSHQRMECT---DNQIRQVNEIVYNSSTISLTSKNCRNPPCN 1589
Query: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDAST---RPRAEEAC---------EDY 970
I ++ SQC+ +CG +R CT RP + C +
Sbjct: 1590 YIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
Query: 971 SGCYE---WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEV 1027
+ C WK G WS CS TCG G+ R V+C+ K G C KP ++CY
Sbjct: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITK-HGLSSDLCLNHLKPGAQKKCYAND 1708
Query: 1028 C 1028
C
Sbjct: 1709 C 1709
Score = 35.0 bits (79), Expect = 0.39
Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 17/71 (23%)
Query: 507 SCKTKLDPPLDGTECG-----ADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGT 561
SC+ LD D + C A+ W +C TP E GDWSP CS +CG
Sbjct: 1178 SCRDALDRIADESYCAHLPRPAEIW----DCF--TPCGEWQAGDWSP------CSASCGH 1225
Query: 562 GARFRQRKCDN 572
G RQ C N
Sbjct: 1226 GKTTRQVLCMN 1236
Score = 31.6 bits (70), Expect = 4.3
Identities = 13/21 (61%), Positives = 13/21 (61%)
Query: 550 GAWSMCSRTCGTGARFRQRKC 570
G WS CS TCG G RQ KC
Sbjct: 1661 GKWSKCSVTCGIGIMKRQVKC 1681
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 446 bits (1148), Expect = e-125
Identities = 330/1033 (31%), Positives = 462/1033 (44%), Gaps = 107/1033 (10%)
Query: 6 LLPPLVLPVLLLLVWGLDP-GTAVGDAAADVEVVLPWRVRPDD--------VHLPPLPAA 56
LLPP P L DP G +G A E +L VR D V A
Sbjct: 27 LLPPPPPPANARLAAAADPPGGPLGHGA---ERILAVPVRTDAQGRLVSHVVSAATSRAG 83
Query: 57 PGPRRRRRPRTP--PAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGA 114
RR RTP P PG L ++ FGRDL+L+LR + R ++ G +E G
Sbjct: 84 VRARRAAPVRTPSFPGGNEEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE 142
Query: 115 -ARRRGRPA-ELCFYSGRVLG-HPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNN--- 168
R P C Y G V G S V+LS C GL GLI++ +E+ I+PL
Sbjct: 143 KGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCD---GLAGLIRMEEEEFFIEPLEKGLA 199
Query: 169 SQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRL 228
+Q GR H++ R+ P S P+ L + + R E N+ R
Sbjct: 200 AQEAEQGRVHVVYRR----PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
Query: 229 TS-------EHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQV 281
+ ++ +E L+ D +VQ+HG E Q+++LT+MN+V ++ +SLG IN+ +
Sbjct: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
Query: 282 TKLVLLR--QRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
+++LL + + + IG+ + SLE+ C W YL G + D A
Sbjct: 316 VRIILLSYGKSMSLIEIGNPSQ-SLENVCRWA--------YLQQKPDTGHDE---YHDHA 363
Query: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
+F+TR DF P G A + G+C R C L ++G + AF +AHE GH LGM H
Sbjct: 364 IFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
Query: 400 DDDHSSCAGRSHIMS--GEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQH 457
D + C + S V+ WS CS+ +L +L S CLL DP +
Sbjct: 419 DGQGNRCGDEVRLGSIMAPLVQAAFHR-FHWSRCSQQELSRYLHSY--DCLL-DDPFAHD 474
Query: 458 TVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHL-MCAGLWCL-VEGDTSCKTKLDPP 515
LP +LPG+HYS NEQC+ FG+ C C LWC + CKTK PP
Sbjct: 475 WPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPP 533
Query: 516 LDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPP 575
LDGT C K C G C+ TP DG W W + CSRTCGTG +FR R+CDNP P
Sbjct: 534 LDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHP 593
Query: 576 GPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD---RLSPKKKGLLTAVVVDDKP 632
GG C G + + +C CP L FR++QC+ D + L D K
Sbjct: 594 ANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKE 653
Query: 633 -CELYCSPLGKESPLLVADRVLDGTPCGPYET-DLCVHGKCQKIGCDGIIGSAAKEDRCG 690
C LYC + + V DGT C + LCV G C+K+GCDG+IGS+ +ED+CG
Sbjct: 654 RCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCG 713
Query: 691 VCSGDGKTCHLVKGDF------------------------------SHARGTALKDSGKG 720
VC GD C +VKG F SH ++GK
Sbjct: 714 VCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKF 773
Query: 721 SINSDWKIELPGEFQIA-GTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYE 779
+N + ++ + IA G Y E + GP + ++V+ D + Y+
Sbjct: 774 ILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYK 833
Query: 780 YTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVN 839
Y + + + + + ++ W W CS CGGG + T C R ++ +V+
Sbjct: 834 YMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDH--KMVH 891
Query: 840 DSDCPQASRPEPQVRRCNLHPC-QSRWVAGPWSPCSATCEK-GFQHREVTCVYQLQNGTH 897
C S+P+ R CN C Q WV G W PCS TC + G Q R V C+ L + T
Sbjct: 892 RGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTT 951
Query: 898 VATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVAC---TNSQGK 954
+ +C RP + ++C + C W A WSQCS +CG G +R V C +S G
Sbjct: 952 RSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI 1011
Query: 955 CDASTRPRAEEAC 967
C RP C
Sbjct: 1012 CQ-EERPETARTC 1023
Score = 83.6 bits (205), Expect = 1e-15
Identities = 68/258 (26%), Positives = 102/258 (39%), Gaps = 34/258 (13%)
Query: 865 WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQ-SCEGQDCL 922
W WSPCS C G Q + C +L H +C +P A++ +C Q+C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLD---HKMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 923 S-IWEASEWSQCSASCGK-GVWKRTVACTNS---------QGKCDASTRPRAEEACEDYS 971
+W EW CS +CG+ G+ R+V C K RP + AC
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSREL 974
Query: 972 GCYEWKTGDWSTCSSTCGKGLQSRVVQC--MHKVTGRHGSECPALSKPAPYRQCYQEVCN 1029
W+ G WS CS TCG G Q R V C G E P ++ C + + +
Sbjct: 975 CPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISD 1034
Query: 1030 DRINANTI--------TSP-RLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
+ + SP R + C D+ +++CR+ C + + CC++C
Sbjct: 1035 PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDK-SIFCRMEVLSRYCSIPGYNKLCCKSC 1093
Query: 1081 RDFYANKMR-----QPPP 1093
+ Y N +PPP
Sbjct: 1094 -NLYNNLTNVEGRIEPPP 1110
Score = 43.9 bits (102), Expect = 8e-04
Identities = 25/68 (36%), Positives = 32/68 (47%), Gaps = 3/68 (4%)
Query: 968 EDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECPALSKP-APYRQCY 1024
E+ S YEW WS CS CG G Q C ++ + H C ALSKP A R C
Sbjct: 850 EEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACN 909
Query: 1025 QEVCNDRI 1032
+ C+ +
Sbjct: 910 PQECSQPV 917
Score = 33.1 bits (74), Expect = 1.5
Identities = 18/57 (31%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 979 GDWS---TCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
G WS +CS TCG G++ R QC + G C L+ ++ C ++ C D +
Sbjct: 565 GAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLA--YDFQLCSRQDCPDSL 619
Score = 32.0 bits (71), Expect = 3.3
Identities = 26/77 (33%), Positives = 30/77 (38%), Gaps = 6/77 (7%)
Query: 544 GDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHA-VCENLPCPKGL- 601
G W G WS CS TCG G + R C G C E A C PCP+ +
Sbjct: 977 GRWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETARTCRLGPCPRNIS 1033
Query: 602 -PSFRDQQCQAHDRLSP 617
PS + Q R P
Sbjct: 1034 DPSKKSYVVQWLSRPDP 1050
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 441 bits (1133), Expect = e-123
Identities = 335/1111 (30%), Positives = 490/1111 (44%), Gaps = 157/1111 (14%)
Query: 30 DAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPP----AAPRARPGERALLLHL 85
+ ++ E+V P RV P RR T P A+ + L
Sbjct: 43 ETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRL 102
Query: 86 PAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRG------RPAEL--CFYSGRVLGHPGS 137
AFG+ L + F++ F V G AEL CFY G V +
Sbjct: 103 SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEH 162
Query: 138 LVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGRE----HLIRRKWSLTPSPSA- 192
+S C G++G + I+PL + E H+I R+ + PS
Sbjct: 163 TAVISLCS---GMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTG 219
Query: 193 --EAQRPEQLCKVLTEKKKP----------------------------TWGRPSRDWRER 222
E + +KKK +G + + RE+
Sbjct: 220 RHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREK 279
Query: 223 RNAIR----LTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKIN 278
R R L+ VE LVVAD MV YHG E Q +ILT+M++V ++++ S+G IN
Sbjct: 280 RTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLIN 338
Query: 279 IQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDA 338
I + L+++ SI + + +L++FC WQ+ + PGG D
Sbjct: 339 IVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNS----------PGGIHH----DT 384
Query: 339 AVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMN 398
AV +TR D C D+ CDT+G+A LG +C R C ++ED+GL+ AFTIAHELGH M
Sbjct: 385 AVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMP 443
Query: 399 HDDDHS----SCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPR 454
HDD++ H+M+ NP WS CSR + FL + CLL +P
Sbjct: 444 HDDNNKCKEEGVKSPQHVMAPTLNFYTNP--WMWSKCSRKYITEFLDTGYGECLL-NEPE 500
Query: 455 SQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCL-VEG-DTSCKTKL 512
S+ LP +LPG+ Y+ N+QC+++FG + C M + C LWC V G C+T+
Sbjct: 501 SR-PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYM--MQCRRLWCNNVNGVHKGCRTQH 557
Query: 513 DPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDN 572
P DGTEC K C+ G CV K DG W W + CSRTCG G + R+C+
Sbjct: 558 TPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNR 617
Query: 573 PPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLL--------- 623
P P GG +C G ++ C PC K FRD+QC D GLL
Sbjct: 618 PEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKY 677
Query: 624 TAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSA 683
+ +++ D+ C+L+C G + + DRV+DGTPCG D+CV G C++ GCD ++ S
Sbjct: 678 SGILMKDR-CKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSK 736
Query: 684 AKEDRCGVCSGDGKTCHLVKGDFS---HARGTALK------------DSGKGSINSDWKI 728
A+ D+CGVC GD +C V G F+ + T ++ S G + D +
Sbjct: 737 ARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL 796
Query: 729 ELP---GEFQIAGTTV-----RYVRRG-----------LWEKISAKGPTKLPLHLMVLL- 768
L GEF + G V R +R G E+I++ + L L VL
Sbjct: 797 ALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV 856
Query: 769 --FHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIW-THSGWEGCSVQCGGGERRTIV 825
++ D + Y + +P+ +KPQ F W +H W+ CS C G +R +V
Sbjct: 857 GKLYNPD--VRYSFNIPIE---------DKPQQ--FYWNSHGPWQACSKPCQGERKRKLV 903
Query: 826 SCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHRE 885
CTR ++ T V+D C + +P C C RW S CSA C G++ +
Sbjct: 904 -CTRESDQLT--VSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLD 959
Query: 886 VTCV-YQLQNGTHVATRPLYCPG-PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWK 943
+ C Y +G +C P+P+ + C G+ W S W++CS SC G +
Sbjct: 960 IYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQR 1019
Query: 944 RTVACTNSQG------KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVV 997
R C N++ KC + + C ++ C +WK+GDWS C TCGKG + R V
Sbjct: 1020 RRAICVNTRNDVLDDSKCTHQEKVTIQR-CSEFP-CPQWKSGDWSECLVTCGKGHKHRQV 1077
Query: 998 QCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
C + C +KP + C Q C
Sbjct: 1078 WCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Score = 149 bits (375), Expect = 2e-35
Identities = 85/241 (35%), Positives = 113/241 (46%), Gaps = 26/241 (10%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
W+ W CSV CG G ++ V C + K + + C ++P R+C C
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYC---MAKDGSHLESDYCKHLAKPHGH-RKCRGGRCP- 1499
Query: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC-PGPRPAAVQSCEGQDC- 921
+W AG WS CS +C +G Q R V C Q GTH R C P RP + + C+G C
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 922 LSIWEASEWSQCSASCGKGVWKRTVACTNSQ------GKCDASTRPRAEEACEDYSGCYE 975
L W A EW +C+ +CG+G R V C + +CD S RP E+C Y
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
Query: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE--------CPALSKPAPYRQCYQEV 1027
W TG+WS CS TCGKG + R+V C TG+ E CP ++P CY
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPG-TQPPSVHPCYLRD 1674
Query: 1028 C 1028
C
Sbjct: 1675 C 1675
Score = 140 bits (352), Expect = 9e-33
Identities = 78/236 (33%), Positives = 111/236 (47%), Gaps = 20/236 (8%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC-- 861
W + W C+ CGGG R +V C R + D C +P P +CN H C
Sbjct: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFP---DLSCEILDKP-PDREQCNTHACPH 1441
Query: 862 QSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEGQD 920
+ W GPWS CS +C +G + R V C+ ++G+H+ + YC +P + C G
Sbjct: 1442 DAAWSTGPWSSCSVSCGRGHKQRNVYCM--AKDGSHLESD--YCKHLAKPHGHRKCRGGR 1497
Query: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK------CDASTRPRAEEACE-DYSGC 973
C W+A WSQCS SCG+GV +R V C K C+ TRP +E C+
Sbjct: 1498 CPK-WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPL 1556
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR-HGSECPALSKPAPYRQCYQEVC 1028
Y W+ +W C+ TCG+G + R V C+ HG+ C +P C + C
Sbjct: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 133 bits (335), Expect = 8e-31
Identities = 88/280 (31%), Positives = 119/280 (42%), Gaps = 62/280 (22%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE------------- 850
W W CSV CG G + V C I+ ++V+D+DC A+RP
Sbjct: 1111 WQAGPWGQCSVTCGQGYQLRAVKC--IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
Query: 851 ---PQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG 907
P+ RR +++W G W+PCSATC KG + R V+C + +NG+ VA
Sbjct: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENGS-VADESACATL 1225
Query: 908 PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTN------SQGKCDASTRP 961
PRP A + C C W+A +WS CS +CG+G R V C N + +CD P
Sbjct: 1226 PRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
Query: 962 RAEEAC---------------------EDYS------------GCYEWKTGDWSTCSSTC 988
++ C EDY G +W+TG W CSSTC
Sbjct: 1285 ETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTC 1344
Query: 989 GKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
G Q RVV C + G ++C KP R C C
Sbjct: 1345 AGGSQRRVVVCQDE-NGYTANDCVERIKPDEQRACESGPC 1383
Score = 120 bits (300), Expect = 9e-27
Identities = 115/463 (24%), Positives = 172/463 (37%), Gaps = 70/463 (15%)
Query: 534 SKTPIPEHVDGDWSPW--GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASV--EH 589
S +P HV G + W G W CS TC G++ R C + G C E
Sbjct: 1318 SASPSRTHVLGG-NQWRTGPWGACSSTCAGGSQRRVVVCQDEN-GYTANDCVERIKPDEQ 1375
Query: 590 AVCENLPCPKGLPSFRDQQCQAHDRLSPKKK----GLLTAVVVDDKPCELYCSPLGKESP 645
CE+ PCP+ A+ K G+ T +VV C+ +
Sbjct: 1376 RACESGPCPQW----------AYGNWGECTKLCGGGIRTRLVV----CQRSNGERFPDLS 1421
Query: 646 LLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDG---KTCHLV 702
+ D+ D C T C H G C V G G + + +
Sbjct: 1422 CEILDKPPDREQCN---THACPHDAAWSTG---------PWSSCSVSCGRGHKQRNVYCM 1469
Query: 703 KGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPL 762
D SH K K G + G + G W + S +
Sbjct: 1470 AKDGSHLESDYCKHLAKPH----------GHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQ 1519
Query: 763 HLMVLLFHDQDYGIHYE---YTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGG 819
+ E YT P E++ + + P+ L+ W W+ C+ CG G
Sbjct: 1520 RHVGCQIGTHKIARETECNPYTRP-----ESERDCQGPRCPLYTWRAEEWQECTKTCGEG 1574
Query: 820 ERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEK 879
R V C V+ V+ + C + RP + C+L PC+ W+ G WS CS TC K
Sbjct: 1575 SRYRKVVC---VDDNKNEVHGARCDVSKRPVDR-ESCSLQPCEYVWITGEWSECSVTCGK 1630
Query: 880 GFQHREVTC--VYQ-LQNGTHVATRPLYCPGPRPAAVQSCEGQDC--LSIWEASEWSQCS 934
G++ R V+C +Y +N + + CPG +P +V C +DC + W W CS
Sbjct: 1631 GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCS 1690
Query: 935 ASCGKGVWKRTVACTNSQGK----CDASTRPRAEEACEDYSGC 973
SCG GV +R+V C ++ + C +P + C + C
Sbjct: 1691 VSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Score = 118 bits (295), Expect = 3e-26
Identities = 76/264 (28%), Positives = 113/264 (42%), Gaps = 29/264 (10%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRI--VNKTTTLVNDSDCPQASRPEPQVR-RCNLHP 860
W + CS QCG G R + C + ++ T V+D C +S P+P R +C+
Sbjct: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFC--SSHPKPSNREKCSGEC 996
Query: 861 CQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQD 920
W W+ CS +C+ G Q R CV N + C +Q C
Sbjct: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICV----NTRNDVLDDSKCTHQEKVTIQRCSEFP 1052
Query: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK-----CDASTRPRAEEACEDYSGCYE 975
C W++ +WS+C +CGKG R V C + + CD T+P + + C+ C
Sbjct: 1053 CPQ-WKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE-CAS 1110
Query: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGS-----ECPALSKPAPYRQCYQEVCND 1030
W+ G W CS TCG+G Q R V+C + G + S +C A ++P + C C+
Sbjct: 1111 WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHP 1167
Query: 1031 RINANTITSPRLAALTYKCTRDQW 1054
+P TY R QW
Sbjct: 1168 -----PPAAPETRRSTYSAPRTQW 1186
Score = 117 bits (294), Expect = 5e-26
Identities = 69/212 (32%), Positives = 101/212 (47%), Gaps = 22/212 (10%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
W W CSV CG G ++ V C +K + +++C +RPE + R C C
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHK---IARETECNPYTRPESE-RDCQGPRCPL 1556
Query: 864 -RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
W A W C+ TC +G ++R+V CV +N H A + RP +SC Q C
Sbjct: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDV---SKRPVDRESCSLQPCE 1613
Query: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQ-GKCD-----------ASTRPRAEEAC--E 968
+W EWS+CS +CGKG +R V+C+ GK + T+P + C
Sbjct: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
Query: 969 DYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCM 1000
D W+ G+W +CS +CG G+ R VQC+
Sbjct: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL 1705
Score = 110 bits (275), Expect = 7e-24
Identities = 81/295 (27%), Positives = 111/295 (37%), Gaps = 52/295 (17%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
W W CS CG G R VSC ++ ++ ++S C RP + C++ PC
Sbjct: 1186 WRFGSWTPCSATCGKGTRMRYVSCR---DENGSVADESACATLPRPVAK-EECSVTPC-G 1240
Query: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL- 922
+W A WS CS TC +G R+V CV HV R P Q C C
Sbjct: 1241 QWKALDWSSCSVTCGQGRATRQVMCV---NYSDHVIDRSECDQDYIPETDQDCSMSPCPQ 1297
Query: 923 --------------------------------SIWEASEWSQCSASCGKGVWKRTVACTN 950
+ W W CS++C G +R V C +
Sbjct: 1298 RTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQD 1357
Query: 951 SQG----KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR 1006
G C +P + ACE C +W G+W C+ CG G+++R+V C R
Sbjct: 1358 ENGYTANDCVERIKPDEQRACES-GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
Query: 1007 HGS-ECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTR--DQWTVYC 1058
C L KP QC C +A T P ++ + C R Q VYC
Sbjct: 1417 FPDLSCEILDKPPDREQCNTHACPH--DAAWSTGP-WSSCSVSCGRGHKQRNVYC 1468
Score = 42.0 bits (97), Expect = 0.003
Identities = 84/366 (22%), Positives = 122/366 (33%), Gaps = 61/366 (16%)
Query: 505 DTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGAR 564
D SC+ LD P D +C T H D WS G WS CS +CG G +
Sbjct: 1419 DLSCEI-LDKPPDREQCN-------------THACPH-DAAWST-GPWSSCSVSCGRGHK 1462
Query: 565 FRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT 624
R C G+H +E C++L P G R +C PK K
Sbjct: 1463 QRNVYC----MAKDGSH-----LESDYCKHLAKPHGHRKCRGGRC-------PKWKAGAW 1506
Query: 625 AVVVDDKPCELYCSPLGKESPL---LVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIG 681
+ C + C ++ + + ++ T C PY T CQ C
Sbjct: 1507 S------QCSVSCGRGVQQRHVGCQIGTHKIARETECNPY-TRPESERDCQGPRCPLYTW 1559
Query: 682 SAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINS---DWKIELPGEFQIAG 738
A + C KTC G+ S R D K ++ D +
Sbjct: 1560 RAEEWQEC------TKTC----GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
Query: 739 TTVRYV-RRGLWEKIS---AKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEP 794
YV G W + S KG + + + ++Y Y+ T+ T P
Sbjct: 1610 QPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHP 1669
Query: 795 EKPQDS--LFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQ 852
+D W W CSV CG G + V C ++ + L + P+ +
Sbjct: 1670 CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRN 1729
Query: 853 VRRCNL 858
V C L
Sbjct: 1730 VYNCEL 1735
Score = 36.6 bits (83), Expect = 0.13
Identities = 40/154 (25%), Positives = 57/154 (37%), Gaps = 27/154 (17%)
Query: 469 HYSANEQCQILFG--MNATFCRNME----HLMC---------AGLWCLVEGDTSCKTKLD 513
H N C G + + +C+++ H C AG W + SC +
Sbjct: 1461 HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWS--QCSVSCGRGVQ 1518
Query: 514 PPLDGTECGADKWCRAGECVSKTPIPEHVD--GDWSP---WGA--WSMCSRTCGTGARFR 566
G + G K R EC T D G P W A W C++TCG G+R+R
Sbjct: 1519 QRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYR 1578
Query: 567 QRKC-DNPPPGPGGTHCPGAS--VEHAVCENLPC 597
+ C D+ G C + V+ C PC
Sbjct: 1579 KVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 34.3 bits (77), Expect = 0.66
Identities = 16/50 (32%), Positives = 23/50 (46%), Gaps = 9/50 (18%)
Query: 549 WGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
+G+W+ CS TCG G R R C + G+ + + C LP P
Sbjct: 1188 FGSWTPCSATCGKGTRMRYVSCRDE---------NGSVADESACATLPRP 1228
Score = 32.7 bits (73), Expect = 1.9
Identities = 22/73 (30%), Positives = 26/73 (35%), Gaps = 15/73 (20%)
Query: 498 LWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSR 557
+WC D DP T + C+ EC S W G W CS
Sbjct: 1077 VWCQFGEDRLNDRMCDPETKPTSM---QTCQQPECAS-----------WQA-GPWGQCSV 1121
Query: 558 TCGTGARFRQRKC 570
TCG G + R KC
Sbjct: 1122 TCGQGYQLRAVKC 1134
Score = 31.2 bits (69), Expect = 5.6
Identities = 23/66 (34%), Positives = 26/66 (39%), Gaps = 6/66 (9%)
Query: 507 SCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFR 566
SC+ + D + C A E S TP G W WS CS TCG G R
Sbjct: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPC-----GQWKALD-WSSCSVTCGQGRATR 1261
Query: 567 QRKCDN 572
Q C N
Sbjct: 1262 QVMCVN 1267
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 431 bits (1108), Expect = e-120
Identities = 334/1067 (31%), Positives = 470/1067 (44%), Gaps = 131/1067 (12%)
Query: 75 RPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPA--ELCFYSGRVL 132
R G +L ++ FG++L+L+LR + R + G VE R R + C Y+G V
Sbjct: 100 RVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVT 159
Query: 133 GHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGP--FSGREHLIRRKWSLTPS- 189
G PG+ V++S C GL GLI+ I+PL Q SGR H++ R+ ++
Sbjct: 160 GMPGAAVAISNCD---GLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEW 216
Query: 190 --PSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY 247
P + L + R+RR+A +++E L+V D +V++
Sbjct: 217 AEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHA--KPGSYSIEVLLVVDDSVVRF 274
Query: 248 HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGE--RSLE 305
HG E Q ++LT+MN+V ++ +SLG+ INI + +L+++ R + LS+ G RSLE
Sbjct: 275 HGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQS-LSLIERGNPSRSLE 333
Query: 306 SFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGG 365
C W + + Q P + D VF+TR DF P G A + G
Sbjct: 334 QVCRWAHSQ--------QRQDPSHAEHH---DHVVFLTRQDF-----GPSGMQGYAPVTG 377
Query: 366 VCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMS--GEWVKGRNP 423
+C R C L ++G + AF IAHE GH LGM HD + CA + + S V+
Sbjct: 378 MCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 437
Query: 424 SDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMN 483
WS CS+ +L +L S CLL D P +LPG++YS +EQC+ FG
Sbjct: 438 R-FHWSRCSKLELSRYLPSY--DCLL--DDPFDPAWPQPPELPGINYSMDEQCRFDFGSG 492
Query: 484 ATFC---RNMEHLMCAGLWCL-VEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIP 539
C R E C LWC + CKTK PPLDGTEC KWC G C+ K+P
Sbjct: 493 YQTCLAFRTFEP--CKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQ 550
Query: 540 EH-VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
+ DG WS W + CSR+CG G R R R C+NP P GG C G E+ VC + CP
Sbjct: 551 TYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
Query: 599 KGLPSFRDQQCQAHDRLSPKKKGLLTAVVV----DDKPCELYCSPLGKESPLLVADRVLD 654
FR QQC + + + V D + CEL C + + V D
Sbjct: 611 GTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHD 670
Query: 655 GTPCG---PYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHA-- 709
GT C PY +C G+C +GCD +GS +D+CGVC GD C VKG A
Sbjct: 671 GTRCSYRDPY--SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASK 728
Query: 710 RGTALK----DSGKGSINSD----------WKIELPGEFQI-----AGTTVRYVRRGL-W 749
+ ALK +G I + K ++ G F + T+ + GL W
Sbjct: 729 QAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEW 788
Query: 750 E------KISAKGPTKLPLHLMVLLFHDQDYG----IHYEYTVPVNRTAENQSEPEKPQD 799
E K S K LP + +L + G + Y+Y + + S ++
Sbjct: 789 EDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEE 848
Query: 800 -SLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
+ W W CS CGGG + T C R + +V C RP+P RRCN
Sbjct: 849 MDTYEWALKSWAPCSKACGGGIQFTKYGCRR--RRDHHMVQRHLCDHKKRPKPIRRRCNQ 906
Query: 859 HPC-QSRWVAGPWSPCSATCEK-GFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC 916
HPC Q WV W CS +C K G Q R + C+ L NGTH C G RP A + C
Sbjct: 907 HPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPC 966
Query: 917 EGQDCLSIWEASEWSQCSASCGKGVWKRTVAC---TNSQGKCDASTRPRAEEACEDYSGC 973
C + W WSQCSA+CG+G+ +R V C NS G C+ RP + C
Sbjct: 967 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD-RPDTVQVCS----- 1020
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRIN 1033
CG Q+ V+ G + S+P IN
Sbjct: 1021 -----------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPL-----------HPIN 1058
Query: 1034 ANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
+ T P CT D+ +V+C++ C +++ CC +C
Sbjct: 1059 KISSTEP--------CTGDR-SVFCQMEVLDRYCSIPGYHRLCCVSC 1096
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 428 bits (1101), Expect = e-119
Identities = 333/1067 (31%), Positives = 469/1067 (43%), Gaps = 134/1067 (12%)
Query: 75 RPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPA--ELCFYSGRVL 132
R G +L ++ FG++L+L+LR + R + G VE R R + C Y+G V
Sbjct: 100 RVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVT 159
Query: 133 GHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGP--FSGREHLIRRKWSLTPS- 189
G PG+ V++S C GL GLI+ I+PL Q SGR H++ R+ ++
Sbjct: 160 GMPGAAVAISNCD---GLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEW 216
Query: 190 --PSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY 247
P + L + R+RR+A +++E L+V D +V++
Sbjct: 217 AEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHA--KPGSYSIEVLLVVDDSVVRF 274
Query: 248 HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGE--RSLE 305
HG E Q ++LT+MN+V ++ +SLG+ INI + +L+++ R + LS+ G RSLE
Sbjct: 275 HGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQS-LSLIERGNPSRSLE 333
Query: 306 SFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGG 365
C W + + Q P + D VF+TR DF G A + G
Sbjct: 334 QVCRWAHSQ--------QRQDPSHAEHH---DHVVFLTRQDF--------GPSGYAPVTG 374
Query: 366 VCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMS--GEWVKGRNP 423
+C R C L ++G + AF IAHE GH LGM HD + CA + + S V+
Sbjct: 375 MCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 434
Query: 424 SDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMN 483
WS CS+ +L +L S CLL D P +LPG++YS +EQC+ FG
Sbjct: 435 R-FHWSRCSKLELSRYLPSY--DCLL--DDPFDPAWPQPPELPGINYSMDEQCRFDFGSG 489
Query: 484 ATFC---RNMEHLMCAGLWCL-VEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIP 539
C R E C LWC + CKTK PPLDGTEC KWC G C+ K+P
Sbjct: 490 YQTCLAFRTFEP--CKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQ 547
Query: 540 EH-VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
+ DG WS W + CSR+CG G R R R C+NP P GG C G E+ VC + CP
Sbjct: 548 TYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
Query: 599 KGLPSFRDQQCQAHDRLSPKKKGLLTAVVV----DDKPCELYCSPLGKESPLLVADRVLD 654
FR QQC + + + V D + CEL C + + V D
Sbjct: 608 GTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHD 667
Query: 655 GTPCG---PYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHA-- 709
GT C PY +C G+C +GCD +GS +D+CGVC GD C VKG A
Sbjct: 668 GTRCSYRDPY--SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASK 725
Query: 710 RGTALK----DSGKGSINSD----------WKIELPGEFQI-----AGTTVRYVRRGL-W 749
+ ALK +G I + K ++ G F + T+ + GL W
Sbjct: 726 QAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEW 785
Query: 750 E------KISAKGPTKLPLHLMVLLFHDQDYG----IHYEYTVPVNRTAENQSEPEKPQD 799
E K S K LP + +L + G + Y+Y + + S ++
Sbjct: 786 EDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEE 845
Query: 800 -SLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
+ W W CS CGGG + T C R + +V C RP+P RRCN
Sbjct: 846 MDTYEWALKSWAPCSKACGGGIQFTKYGCRR--RRDHHMVQRHLCDHKKRPKPIRRRCNQ 903
Query: 859 HPC-QSRWVAGPWSPCSATCEK-GFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC 916
HPC Q WV W CS +C K G Q R + C+ L NGTH C G RP A + C
Sbjct: 904 HPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPC 963
Query: 917 EGQDCLSIWEASEWSQCSASCGKGVWKRTVAC---TNSQGKCDASTRPRAEEACEDYSGC 973
C + W WSQCSA+CG+G+ +R V C NS G C+ RP + C
Sbjct: 964 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD-RPDTVQVCS----- 1017
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRIN 1033
CG Q+ V+ G + S+P IN
Sbjct: 1018 -----------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPL-----------HPIN 1055
Query: 1034 ANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
+ T P CT D+ +V+C++ C +++ CC +C
Sbjct: 1056 KISSTEP--------CTGDR-SVFCQMEVLDRYCSIPGYHRLCCVSC 1093
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 426 bits (1096), Expect = e-119
Identities = 298/972 (30%), Positives = 447/972 (45%), Gaps = 124/972 (12%)
Query: 81 LLLHLPAFGRDLYLQLRRDLRFLSRGFEVE------------------EAGAARRRGRPA 122
L ++ AFG+D +L+L+ + + ++ G VE + G+A R R
Sbjct: 80 LFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKT 139
Query: 123 EL----CFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQG--PFSGR 176
E C Y G ++ PG+ V++S C GL G+I+ E+ I+PL + GR
Sbjct: 140 EPLQTNCAYVGDIVDIPGTSVAISNCD---GLAGMIKSDNEEYFIEPLERGKQMEEEKGR 196
Query: 177 EHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWG-------------RPSRDWRERR 223
H++ ++ SA Q P + K ++ G + + R RR
Sbjct: 197 IHVVYKR-------SAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRR 249
Query: 224 NAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTK 283
+A +++ +E L+ D +V++HG E Q ++LT+MN+V ++ +SLG+ IN+ + +
Sbjct: 250 HAGE--NDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVR 307
Query: 284 LVLLRQRPAKLSIGHHGE--RSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVF 341
+++L + +S+ G RSLE+ C W +++ + D A+F
Sbjct: 308 MIMLGYAKS-ISLIERGNPSRSLENVCRWASQQQRSDLNHSEHH-----------DHAIF 355
Query: 342 VTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDD 401
+TR DF P G A + G+C R C L ++G + AF +AHE GH LGM HD
Sbjct: 356 LTRQDF-----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 410
Query: 402 DHSSCAGRSHIMS--GEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV 459
+ C + + S V+ WS CS +L+ ++ S CLL DP
Sbjct: 411 QGNRCGDETAMGSVMAPLVQAAFHR-YHWSRCSGQELKRYIHSY--DCLL-DDPFDHDWP 466
Query: 460 RLPHKLPGMHYSANEQCQILFGMNATFCRNMEHL-MCAGLWCL-VEGDTSCKTKLDPPLD 517
+LP +LPG++YS +EQC+ FG+ C C LWC + CKTK PPLD
Sbjct: 467 KLP-ELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLD 525
Query: 518 GTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGP 577
GTEC A KWC G C+ K + DG+W W + CSRTCGTG RFR R+C+NP P
Sbjct: 526 GTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPIN 585
Query: 578 GGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQ---AHDRLSPKKKGLLTAVVVDDKP-C 633
GG CPG + E+ +C C K FR QQCQ +H K L D K C
Sbjct: 586 GGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRC 645
Query: 634 ELYCSPLGKESPLLVADRVLDGTPCG---PYETDLCVHGKCQKIGCDGIIGSAAKEDRCG 690
LYC + V DGT C PY +CV G+C K+GCD IGS ED+CG
Sbjct: 646 HLYCQSKETGDVAYMKQLVHDGTHCSYKDPY--SICVRGECVKVGCDKEIGSNKVEDKCG 703
Query: 691 VCSGDGKTCHLVKGDFSH----------------ARGTALKDSGKGSINSDWKIELPGEF 734
VC GD C VKG F+ AR +++ K + G +
Sbjct: 704 VCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHY 763
Query: 735 QIAG-----TTVRYVRRGL-W--------EKISAKGPTKLPLHLMVL-LFHDQDYGIHYE 779
+ G + ++ G+ W E + GP P+ ++++ +D + Y+
Sbjct: 764 ILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYK 823
Query: 780 YTVPVNRTAE-NQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV 838
Y + + N + + + F W W CS CGGG + T C R +V
Sbjct: 824 YIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRR--KSDNKMV 881
Query: 839 NDSDCPQASRPEPQVRRCNLHPC-QSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGT 896
+ S C +P+P R CN+ C WVA W C+ TC G+Q R V C+ L +GT
Sbjct: 882 HRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGT 941
Query: 897 HVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCD 956
+ + YC G RP + + C C + W+ WS+CS +CG+G R V C + CD
Sbjct: 942 NRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC-RAGDHCD 1000
Query: 957 ASTRPRAEEACE 968
+P + AC+
Sbjct: 1001 GE-KPESVRACQ 1011
Score = 93.6 bits (231), Expect = 9e-19
Identities = 69/241 (28%), Positives = 94/241 (39%), Gaps = 41/241 (17%)
Query: 865 WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQS-CEGQDCLS 923
W WS CS C GFQ+ + C + N + R +P ++ C Q+C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDN--KMVHRSFCEANKKPKPIRRMCNIQECTH 906
Query: 924 -IWEASEWSQCSASCGK-GVWKRTVAC-------TNSQ--GKCDASTRPRAEEACEDYSG 972
+W A EW C+ +CG G RTV C TN K RP + C
Sbjct: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPC 966
Query: 973 CYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
+WKTG WS CS TCG+G + R V C R G C KP R C CND
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLC------RAGDHCDG-EKPESVRACQLPPCNDE- 1018
Query: 1033 NANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPP 1092
C D+ +++C++ C + + CC++C PP
Sbjct: 1019 ---------------PCLGDK-SIFCQMEVLARYCSIPGYNKLCCESCS---KRSSTLPP 1059
Query: 1093 P 1093
P
Sbjct: 1060 P 1060
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/89 (34%), Positives = 34/89 (38%), Gaps = 10/89 (11%)
Query: 512 LDPPLDGTECGA-DKWCRAGECVSKTPIPE-HVDGDWSPWGAWSMCSRTCGTGARFRQRK 569
L P LDGT K+C S+ P W G WS CS TCG G RQ
Sbjct: 934 LQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKT-GPWSECSVTCGEGTEVRQVL 992
Query: 570 CDNPPPGPGGTHCPGASVEHA-VCENLPC 597
C G HC G E C+ PC
Sbjct: 993 C------RAGDHCDGEKPESVRACQLPPC 1015
Score = 41.6 bits (96), Expect = 0.004
Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECPALSKPAPYRQ-CYQEVC 1028
+EW WS CS CG G Q C K + H S C A KP P R+ C + C
Sbjct: 847 FEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
Score = 39.3 bits (90), Expect = 0.021
Identities = 32/125 (25%), Positives = 47/125 (37%), Gaps = 19/125 (15%)
Query: 948 CTNSQGKCDASTRPRAEEACEDYSGCYEWKT----------GDWS---TCSSTCGKGLQS 994
C +G T A + C Y G WK G W+ +CS TCG G++
Sbjct: 516 CKTKKGPPLDGTECAAGKWC--YKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRF 573
Query: 995 RVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRIN--ANTITSPRLAALTYKCTRD 1052
R QC + + G +CP ++ Y+ C E C R + Y+ T+
Sbjct: 574 RTRQCNNPMPINGGQDCPGVN--FEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKH 631
Query: 1053 QWTVY 1057
W Y
Sbjct: 632 HWLPY 636
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 407 bits (1047), Expect = e-113
Identities = 307/963 (31%), Positives = 437/963 (45%), Gaps = 152/963 (15%)
Query: 25 GTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLH 84
G G + + EVV+P R+ PD RR R P + G++ L+
Sbjct: 13 GRTAGGSEPEREVVVPIRLDPDI-----------NGRRYYWRGPEDS-----GDQGLIFQ 56
Query: 85 LPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARR--RGRPAEL--CFYSGRVLGHPGSLVS 140
+ AF D YL L D +FL+ F E G + G ++L CFYSG V P S +
Sbjct: 57 ITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAA 116
Query: 141 LSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGRE----HLIRRKWSLTPSPSAEAQR 196
+S CG G G G E V I PL N+ P + R HL++R+ + PS +
Sbjct: 117 VSLCGGLRGAFGY--RGAEYV-ISPLPNASAPAAQRNSQGAHLLQRR-GVPGGPSGD--- 169
Query: 197 PEQLCKVLT-------------EKKKPTWGRPSRDWRERRNAIRLTS-EHTVETLVVADA 242
P C V + + ++ +G SR R A R S VETLVVAD
Sbjct: 170 PTSRCGVASGWNPAILRALDPYKPRRAGFGE-SRSRRRSGRAKRFVSIPRYVETLVVADE 228
Query: 243 DMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGER 302
MV++HGA+ + ++LT++ +++H S+ INI V K++LLR R + + +
Sbjct: 229 SMVKFHGADL-EHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAAL 287
Query: 303 SLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAY 362
+L +FC WQ + N+V P D A+ TR D C CDT+G+A
Sbjct: 288 TLRNFCAWQKKL---------NKV--SDKHPEYWDTAILFTRQDLC--GATTCDTLGMAD 334
Query: 363 LGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHD-----DDHSSCAGRSHIMSGEW 417
+G +C KR C + ED+GL AFT AHELGH M HD ++ +H+MS
Sbjct: 335 VGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTL 394
Query: 418 VK--GRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQ 475
++ NP WS+CS + +FL S CLL + + LP LPG Y+ ++Q
Sbjct: 395 IQIDRANP----WSACSAAIITDFLDSGHGDCLL---DQPSKPISLPEDLPGASYTLSQQ 447
Query: 476 CQILFGMNATFCRNMEHLMCAGLWCL--VEGDTSCKTKLDPPLDGTECGADKWCRAGECV 533
C++ FG+ + C M++ C LWC +G C+T+ P DGT CG K C G CV
Sbjct: 448 CELAFGVGSKPCPYMQY--CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACV 505
Query: 534 SKTPIPEH-VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVC 592
+ + +H VDG W+ W + CSRTCG G + +R+C NP P GG +C G V++ C
Sbjct: 506 ERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSC 565
Query: 593 ENLPCPKGLP--SFRDQQCQAHDRLSPKKKGLLTAVVVDDK--------PCELYCSPLGK 642
PCP SFR++QC+A + + L AV K C+L C G
Sbjct: 566 NLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGT 625
Query: 643 ESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLV 702
++A +V+DGT C P T +CV GKC K GCDG +GS + D+CGVC GD K+C V
Sbjct: 626 GYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKV 685
Query: 703 KGDFSH--------------ARGTALKDSG-KGSI---------NSDWKIELPGEFQIA- 737
G F+ A ++ G KG I NS K L G F ++
Sbjct: 686 TGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSA 745
Query: 738 --------GTTVRYVRRG-LWEKISAKGPTKLPLHLMVLLFHDQ-DYGIHYEYTVPVNRT 787
G+ +RY G E + A P PL + VL + Y + +P
Sbjct: 746 VERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPR 805
Query: 788 AENQSEPEKPQDSLFI---------------------WTHSGWEGCSVQCGGGERRTIVS 826
+ S P+ P+ + W W CS CG G ++ V
Sbjct: 806 EDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVD 865
Query: 827 CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREV 886
C + T C A RP + + C PC + W WSPCS +C +GFQ R +
Sbjct: 866 CRGSAGQRTV----PACDAAHRP-VETQACG-EPCPT-WELSAWSPCSKSCGRGFQRRSL 918
Query: 887 TCV 889
CV
Sbjct: 919 KCV 921
Score = 77.0 bits (188), Expect = 9e-14
Identities = 41/110 (37%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 925 WEASEWSQCSASCGKGVWKRTVACTNSQGK-----CDASTRPRAEEACEDYSGCYEWKTG 979
W A W CSASCG G+ KR V C S G+ CDA+ RP +AC + C W+
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE--PCPTWELS 900
Query: 980 DWSTCSSTCGKGLQSRVVQCM-HKVTGRHGSECPALSKPAPYRQCYQEVC 1028
WS CS +CG+G Q R ++C+ H +C KP C C
Sbjct: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 34.7 bits (78), Expect = 0.51
Identities = 41/175 (23%), Positives = 57/175 (32%), Gaps = 17/175 (9%)
Query: 867 AGPWSPCSATCEKGF-QHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIW 925
A PWS CSA F C+ L + + P PG Q CE +
Sbjct: 400 ANPWSACSAAIITDFLDSGHGDCL--LDQPSKPISLPEDLPGASYTLSQQCELAFGVGSK 457
Query: 926 EASEWSQCSASCGKGVWKRTVACTN-----SQGKCDASTRPRAEEACEDYSGCYEWKT-G 979
C+ G K + C + G + + AC + + + G
Sbjct: 458 PCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDG 517
Query: 980 DWST------CSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
W+ CS TCG G+Q QC + G C + YR C E C
Sbjct: 518 SWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR--VKYRSCNLEPC 570
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 400 bits (1027), Expect = e-111
Identities = 287/914 (31%), Positives = 409/914 (44%), Gaps = 133/914 (14%)
Query: 69 PAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAEL---- 124
P RA PG L L AF + L L+LR D FL+ GF ++ G R+ G L
Sbjct: 63 PELERA-PGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVG--RKSGSETPLPETD 119
Query: 125 ---CFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLN-----------NSQ 170
CFYSG V G P S +LS C G+ G L E IQPL +
Sbjct: 120 LAHCFYSGTVNGDPSSAAALSLCE---GVRGAFYLLGEAYFIQPLPAASERLATAAPGEK 176
Query: 171 GPFSGREHLIRRKWSLT-----------PSPSAEAQRPEQLCKVLTEKKKPTW------- 212
P + HL+RR P P+ +A+ ++ E + W
Sbjct: 177 PPAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPAL 236
Query: 213 ---GRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQ 269
G+P+ R+ ++S VET++VAD M ++HG+ + ++LT+ ++ +++
Sbjct: 237 QGVGQPTGTGSIRKKRF-VSSHRYVETMLVADQSMAEFHGS-GLKHYLLTLFSVAARLYK 294
Query: 270 HQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGG 329
H S+ +++ V K++++ + + +L +FC+WQ + P
Sbjct: 295 HPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHN-----------PPS 343
Query: 330 KDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAH 389
D D A+ TR D C + CDT+G+A +G VC R C + ED+GL AFT AH
Sbjct: 344 DRDAEHYDTAILFTRQDLC--GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAH 401
Query: 390 ELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLS----WSSCSRDDLENFLKSKVS 445
ELGH M HDD CA + + + S+L WS CS + +FL +
Sbjct: 402 ELGHVFNMPHDDA-KQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHG 460
Query: 446 TCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVE-- 503
CL+ + Q+ ++LP LPG Y AN QCQ FG ++ C + C+ LWC
Sbjct: 461 ECLM---DKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAAST-CSTLWCTGTSG 516
Query: 504 GDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVD----GDWSPWGAWSMCSRTC 559
G C+TK P DGT CG KWC G+CV+KT +H D G W WG W CSRTC
Sbjct: 517 GVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTD-RKHFDTPFHGSWGMWGPWGDCSRTC 575
Query: 560 GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGL-PSFRDQQCQAHDRLSPK 618
G G ++ R+CDNP P GG +C G V + C CP +FR++QC+AH+ S
Sbjct: 576 GGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKA 635
Query: 619 KKGLLTAV--------VVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGK 670
G AV V C+L C G ++ +V+DGTPC P T +CV G+
Sbjct: 636 SFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQ 695
Query: 671 CQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHA--------------------- 709
C K GCD II S K D+CGVC G+G TC + G + A
Sbjct: 696 CVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQ 755
Query: 710 ---RGTALKDS--------GKGSINSDWKIE-LPGEFQIAGTTVRYV-RRGLWEKISAKG 756
RG+ S G +N D+ + L + G +RY E+I +
Sbjct: 756 RNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFS 815
Query: 757 PTKLPLHLMVLLFHDQ-DYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQ 815
P K PL + VL + I Y Y V + + N + W W CS
Sbjct: 816 PLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIP------TFSAWVIEEWGECSKS 869
Query: 816 CGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSA 875
C G +R +V C I + S+C + +P R C HPC +W G WS CS
Sbjct: 870 CELGWQRRLVECRDINGQPA-----SECAKEVKPA-STRPCADHPCP-QWQLGEWSSCSK 922
Query: 876 TCEKGFQHREVTCV 889
TC KG++ R + C+
Sbjct: 923 TCGKGYKKRSLKCL 936
Score = 76.3 bits (186), Expect = 2e-13
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 6/100 (6%)
Query: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEEACEDYSGCYEWKT 978
S W EW +CS SC G +R V C + G+ C +P + C D+ C +W+
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHP-CPQWQL 914
Query: 979 GDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE-CPALSKP 1017
G+WS+CS TCGKG + R ++C+ G E C L KP
Sbjct: 915 GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 49.7 bits (117), Expect = 2e-05
Identities = 55/198 (27%), Positives = 72/198 (36%), Gaps = 60/198 (30%)
Query: 869 PWSPCSATCEKGFQHREVTCVYQLQNG-----THVATRPLYCPGPRPA----AVQSCE-- 917
PWSPCSA F L NG P+ PG P A + C+
Sbjct: 442 PWSPCSAYMITSF----------LDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFT 491
Query: 918 -GQD----------CLSIW-------------EASEWSQCSASCGKGVWKRTVACTNSQG 953
G+D C ++W + W+ SCG+G W C N G
Sbjct: 492 FGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEGKW-----CIN--G 543
Query: 954 KCDASTRPRAEEACEDYSGCYE-WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECP 1012
KC T + + + G + W G W CS TCG G+Q + +C + V G C
Sbjct: 544 KCVNKTDRKHFDT--PFHGSWGMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCE 599
Query: 1013 ALSKPAPYRQCYQEVCND 1030
K YR C E C D
Sbjct: 600 --GKRVRYRSCNLEDCPD 615
Score = 44.3 bits (103), Expect = 6e-04
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
W +W CS +C G Q R+V+C + G+ SEC KPA R C C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVEC-RDINGQPASECAKEVKPASTRPCADHPC 909
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 370 bits (951), Expect = e-102
Identities = 303/1002 (30%), Positives = 433/1002 (43%), Gaps = 174/1002 (17%)
Query: 15 LLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRT------P 68
LLL + L P AVG AA + D PP AA RRR+ P
Sbjct: 8 LLLCAFRL-PLAAVGPAATPAQ---------DKAGQPPTAAAAAQPRRRQGEEVQERAEP 57
Query: 69 PAAPRA---RPGERALLLHLP--------------AFGRDLYLQLRRDLRFLSRGFEVEE 111
P P R + L+ ++ A GR L L RD GF V
Sbjct: 58 PGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGF-VPA 116
Query: 112 AGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQG 171
G R CFY G V G P SL CG GL G + + ++PL +G
Sbjct: 117 GGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCG---GLDGFFAVKHARYTLKPL--LRG 171
Query: 172 PFSGRE-------------HLIRRKW----SLTPSPSAE--AQRPEQ------------- 199
P++ E H+ R+ +L P S E A PE
Sbjct: 172 PWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGR 231
Query: 200 --LCKVLTEKK--KPTWGR-PSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQ 254
L L ++ P G P WR RR +I + VE L+VADA M + +G Q
Sbjct: 232 AALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQ--VELLLVADASMARLYG-RGLQ 288
Query: 255 RFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEE 314
++LT+ ++ ++ H S+ I + V K+V+L + L + + +L++FC WQ++
Sbjct: 289 HYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQ- 347
Query: 315 YGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCV 374
+NQ+ G D DAA+ TR D C H CDT+G+A +G +CS +R C
Sbjct: 348 --------HNQL--GDDHEEHYDAAILFTREDLCGHHS--CDTLGMADVGTICSPERSCA 395
Query: 375 LAEDNGLNLAFTIAHELGHNLGMNHDD-----DHSSCAGRSHIMSGEWVKGRNPSDLSWS 429
+ ED+GL+ AFT+AHE+GH LG++HDD + +MS + + WS
Sbjct: 396 VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSS--ILTSIDASKPWS 453
Query: 430 SCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRN 489
C+ + FL CLL PR Q + P +LPG Y A +QC + FG + C
Sbjct: 454 KCTSATITEFLDDGHGNCLLDL-PRKQ--ILGPEELPGQTYDATQQCNLTFGPEYSVCPG 510
Query: 490 MEHLMCAGLWCLV--EGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVD---G 544
M+ +CA LWC V +G C TK P ++GT CG + C G+CV KT + G
Sbjct: 511 MD--VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHG 568
Query: 545 DWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSF 604
+W WG+W CSR+CG G +F R C+NP P G +C G + C +PCP SF
Sbjct: 569 NWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSF 628
Query: 605 RDQQCQAHDRLSPKKKGLLTAV--------VVDDKPCELYCSPLGKESPLLVADRVLDGT 656
R +QC+A + KG+ T V V+ C+L C G ++ + +V DGT
Sbjct: 629 RHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGT 688
Query: 657 PCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKD 716
C Y +CV GKC + GCDGIIGS + D+CGVC GD +C + G F+ K
Sbjct: 689 ECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK------KS 742
Query: 717 SGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGI 776
G + + +P G T VR + AK T+ +L L + +Y I
Sbjct: 743 KGYTDV-----VRIP-----EGATHIKVR-----QFKAKDQTRFTAYL-ALKKKNGEYLI 786
Query: 777 HYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTT 836
+ +Y + + T + + + +SGW G S T+ +
Sbjct: 787 NGKYMISTSETIIDINGT--------VMNYSGWSHRDDFLHG----MGYSATKEILIVQI 834
Query: 837 LVNDSDCPQASR-----PEPQVRRCN-----------LHPCQSRWVAGPWSPCSATCEKG 880
L D P R P+ + N H Q +WV GPW CS TC+ G
Sbjct: 835 LATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTG 894
Query: 881 FQHREVTCVYQLQNGTHVATRPLYCP-GPRPAAVQSCEGQDC 921
+ R V C Q+G + CP RP+A + C + C
Sbjct: 895 WHTRTVQC----QDGNRKLAKG--CPLSQRPSAFKQCLLKKC 930
Score = 46.2 bits (108), Expect = 2e-04
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 1/54 (1%)
Query: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
+W TG W CS TC G +R VQC + CP +P+ ++QC + C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDG-NRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 39.3 bits (90), Expect = 0.021
Identities = 49/185 (26%), Positives = 60/185 (32%), Gaps = 39/185 (21%)
Query: 869 PWSPC-SATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCE---------- 917
PWS C SAT + C+ L + L PG A Q C
Sbjct: 451 PWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEEL--PGQTYDATQQCNLTFGPEYSVC 508
Query: 918 -GQD-CLSIWEA---SEWSQC---------SASCGKGVWKRTVACTNSQGKCDASTRPRA 963
G D C +W A C CGKG C QGKC T+ +
Sbjct: 509 PGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGR-----ICL--QGKCVDKTKKKY 561
Query: 964 EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQC 1023
+ W G W CS +CG G+Q C + +G C K A YR C
Sbjct: 562 YST-SSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRSC 616
Query: 1024 YQEVC 1028
C
Sbjct: 617 SLMPC 621
Score = 34.3 bits (77), Expect = 0.66
Identities = 17/47 (36%), Positives = 20/47 (42%), Gaps = 4/47 (8%)
Query: 925 WEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEEAC 967
W W CS +C G RTV C + K C S RP A + C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
Score = 30.4 bits (67), Expect = 9.6
Identities = 21/71 (29%), Positives = 26/71 (36%), Gaps = 6/71 (8%)
Query: 868 GPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEA 927
G W CS +C G Q Y+ N YC G R A +SC C ++
Sbjct: 574 GSWGQCSRSCGGGVQF-----AYRHCNNPAPRNNGRYCTGKR-AIYRSCSLMPCPPNGKS 627
Query: 928 SEWSQCSASCG 938
QC A G
Sbjct: 628 FRHEQCEAKNG 638
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 345 bits (884), Expect = 2e-94
Identities = 271/907 (29%), Positives = 395/907 (43%), Gaps = 137/907 (15%)
Query: 52 PLPAAPG------------PRRRRRPRTPPAA--------PRARPGERA-LLLHLPAFGR 90
P PAAP P R P P A P PG L LHL AFG+
Sbjct: 3 PAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAFGK 62
Query: 91 DLYLQLRRDLRFLSRGFEVEEAGAARRRG---RPAELCFYSGRVLGHPGSLVSLSACGAA 147
L+L D FL+ F++E G + R R CF+SG V G P SL ++S C
Sbjct: 63 GFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR-- 120
Query: 148 GGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRR-------------KWSLTPSPSAEA 194
GL G L E+ IQP G + H ++R +W +
Sbjct: 121 -GLSGSFLLDGEEFTIQP--QGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQ 177
Query: 195 QR---PEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSE-HTVETLVVADADMVQYHGA 250
+R E + E++ P R SE VETL+VADA M ++GA
Sbjct: 178 ERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGA 237
Query: 251 EAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHW 310
+ Q ILT+M++ +++H S+ IN+ V K++++ + +G +L +FC+W
Sbjct: 238 DL-QNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNW 296
Query: 311 QNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAK 370
Q NQ P + P D A+ +TR +FC ++ CDT+G+A +G +C
Sbjct: 297 QRRF---------NQ-PSDRH-PEHYDTAILLTRQNFC-GQEGLCDTLGVADIGTICDPN 344
Query: 371 RKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCA-----GRSHIMSGEWVKGRNPSD 425
+ C + ED GL A T+AHELGH L M HDD G+ H+M+ +V
Sbjct: 345 KSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQT-- 402
Query: 426 LSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMH--YSANEQCQILFGMN 483
L WS CS L L CLL + + LP LPG Y ++QC+ +FG +
Sbjct: 403 LPWSPCSAMYLTELLDGGHGDCLLDAPAAA---LPLPTGLPGRMALYQLDQQCRQIFGPD 459
Query: 484 ATFCRNMEHL-MCAGLWCLVEG-DTSCKTKLD--PPLDGTECGADKWCRAGECVSKTPI- 538
C N +CA LWC +G + C TK P DGT CG C G C+ + +
Sbjct: 460 FRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVE 519
Query: 539 -PEHV-DGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLP 596
P+ V DG W+PWG W CSRTCG G +F R+C +P P GG +C G ++ C
Sbjct: 520 RPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEE 579
Query: 597 CPKGLPSFRDQQCQAHDRLS------------PKKKGLLTAVVVDDKPCELYCSPLGKES 644
CP SFR+QQC+ ++ + PK G V C+L+C G+
Sbjct: 580 CPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAG-----VSPRDRCKLFCRARGRSE 634
Query: 645 PLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKG 704
+ +V+DGT CGP +CV G+C K GCD ++ S K D+CGVC G G +C V G
Sbjct: 635 FKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSG 694
Query: 705 DF-------------------------SH------ARGTALKDS-GKGSINSDWKIE-LP 731
SH ALK + G+ +N + I +
Sbjct: 695 SLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIE 754
Query: 732 GEFQIAGTTVRYVRR-GLWEKISAKGPTKLPLHLMVLLFHDQDY--GIHYEYTVPVNRTA 788
+ + GT ++Y E++ + P PL + +L + + + Y + VP +
Sbjct: 755 QDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDF 814
Query: 789 ENQSEPEKPQDSLF------IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSD 842
QS E+ ++ W W CS CG G +R V C + + N +
Sbjct: 815 SMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKAL 874
Query: 843 CPQASRP 849
P+ ++P
Sbjct: 875 KPEDAKP 881
Score = 51.6 bits (122), Expect = 4e-06
Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
+W GDWS CSSTCG G Q R V+C +G+ + C KP + C ++C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 43.5 bits (101), Expect = 0.001
Identities = 17/48 (35%), Positives = 28/48 (58%), Gaps = 4/48 (8%)
Query: 925 WEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEEACE 968
W +WS+CS++CG G +RTV C + G+ C+ + +P + CE
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCE 883
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/91 (29%), Positives = 36/91 (39%), Gaps = 5/91 (5%)
Query: 831 VNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVY 890
V T + ND D S E ++WV G WS CS+TC G+Q R V C
Sbjct: 802 VKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD 861
Query: 891 QLQNGTHVATRPLYCPGPRPAAVQSCEGQDC 921
+ + L +P + CE Q C
Sbjct: 862 PSGQASATCNKAL-----KPEDAKPCESQLC 887
Score = 40.8 bits (94), Expect = 0.007
Identities = 34/129 (26%), Positives = 47/129 (36%), Gaps = 12/129 (9%)
Query: 907 GPRPAAVQSCEGQD-CLSIWEASEWSQ--CSASCGKGVWKRTVACTN----SQGKCDAST 959
GP + QD C +W ++ ++ C G W C S+G C
Sbjct: 457 GPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEE 516
Query: 960 RPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAP 1019
+ D G W G W CS TCG G+Q +C G C L + A
Sbjct: 517 EVERPKPVAD-GGWAPW--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC--LGRRAK 571
Query: 1020 YRQCYQEVC 1028
Y+ C+ E C
Sbjct: 572 YQSCHTEEC 580
Score = 36.6 bits (83), Expect = 0.13
Identities = 26/68 (38%), Positives = 31/68 (45%), Gaps = 10/68 (14%)
Query: 868 GPWSPCSATCEKG--FQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIW 925
GPW CS TC G F HRE + QNG YC G R A QSC ++C
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKDP-EPQNGGR------YCLG-RRAKYQSCHTEECPPDG 584
Query: 926 EASEWSQC 933
++ QC
Sbjct: 585 KSFREQQC 592
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 341 bits (875), Expect = 2e-93
Identities = 290/948 (30%), Positives = 396/948 (41%), Gaps = 142/948 (14%)
Query: 208 KKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNM 267
+ P+ G + R+RR A + +E LV D+ Q H E +R++LT +N+ +
Sbjct: 59 RPPSPGFQRQRQRQRRAAGGILH---LELLVAVGPDVFQAH-QEDTERYVLTNLNIGAEL 114
Query: 268 FQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVP 327
+ SLG + + + K+V+L + +I + SL S C W P
Sbjct: 115 LRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTIN-----------P 163
Query: 328 GGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTI 387
DP D +++TR D + D G+ LGG CS C++ ED G +L TI
Sbjct: 164 EDDTDPGHADLVLYITRFDLEL-PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTI 222
Query: 388 AHELGHNLGMNHDD-DHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVST 446
AHE+GH+ G+ HD S C H+M+ + R + L+WS CSR L + L + +
Sbjct: 223 AHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR--AGLAWSPCSRRQLLSLLSAGRAR 280
Query: 447 CLLVTDPRSQ--HTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHL-MCAGLWCLV 502
C+ PR Q P PG++YSANEQC++ FG A C EHL MC L C
Sbjct: 281 CVW-DPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHT 339
Query: 503 E--GDTSCKTKLDPPLDGTECGADKWCRAGEC---VSKTPIPEHVDGDWSPWGAWSMCSR 557
+ +SC L P LDGTECG +KWC G C V TPI V G WS WG S CSR
Sbjct: 340 DPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAA-VHGRWSSWGPRSPCSR 398
Query: 558 TCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD---- 613
+CG G R+R+C+NP P GG C GA ++ +C C K F QQC D
Sbjct: 399 SCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPL 458
Query: 614 RLSPKKK-----GLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPC---GPYE--- 662
R SP G D C C +G+ + D LDGT C GP E
Sbjct: 459 RSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGT 518
Query: 663 TDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARG----------- 711
LCV G C+ GCDG + S DRC VC GD TC KG F+ R
Sbjct: 519 LSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP 578
Query: 712 --TALKDSGKGSINSDWKIELPGEFQIAG-------TT---------VRY------VRRG 747
T++ + + + + + G + +AG TT V Y R
Sbjct: 579 NLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLP 638
Query: 748 LWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHS 807
E+I GP + + V + ++YG T P Q +P + W +
Sbjct: 639 RLEEIRIWGPLQEDADIQVYRRYGEEYG---NLTRPDITFTYFQPKPRQ------AWVWA 689
Query: 808 GWEG-CSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWV 866
G CSV CG G R SC K LV C + +P C L PC W
Sbjct: 690 AVRGPCSVSCGAGLRWVNYSCLDQARK--ELVETVQCQGSQQPPAWPEACVLEPCPPYWA 747
Query: 867 AGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC--PGPRPA-AVQSCEGQDCLS 923
G + PCSA+C G + R V CV + Q P C +PA A+++C Q C +
Sbjct: 748 VGDFGPCSASCGGGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA 806
Query: 924 IWEASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDYSGCY 974
WE SE S C+++ G G+ C ++G + A E C S
Sbjct: 807 RWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPP 866
Query: 975 EW-------------------KTGD-----WS----TCSSTCGKGLQSRVVQCMHKVTGR 1006
W +TG W+ +CS +CG+GL CM
Sbjct: 867 GWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRV 926
Query: 1007 HGSE--CPALSKPAPYRQCYQEV-CNDRINANTITSPRLAALTYKCTR 1051
E C SKP R+ Q V C R +LAA + C R
Sbjct: 927 PVQEELCGLASKPGSRREVCQAVPCPAR------WQYKLAACSVSCGR 968
Score = 101 bits (251), Expect = 4e-21
Identities = 70/240 (29%), Positives = 95/240 (39%), Gaps = 19/240 (7%)
Query: 803 IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
+WT + CSV CG G C + V + C AS+P + C PC
Sbjct: 896 VWTPAAGS-CSVSCGRGLMELRFLCMDSALRVP--VQEELCGLASKPGSRREVCQAVPCP 952
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCV--YQLQNGTHVATRPLYCPG-PRPAAVQSCEGQ 919
+RW + CS +C +G R + C + +G + C G PRP ++C +
Sbjct: 953 ARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQCQGLPRPEPQEACSLE 1010
Query: 920 DCLSIWEASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDY 970
C W+ CSASCG G +R+VAC + C A RP A C
Sbjct: 1011 PCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIA 1070
Query: 971 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCM--HKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Y W G W CS +CG G+Q R C+ C L KP R C+ C
Sbjct: 1071 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 77.4 bits (189), Expect = 7e-14
Identities = 67/273 (24%), Positives = 96/273 (35%), Gaps = 48/273 (17%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQ-ASRPEPQVRRCNLHPCQ 862
W + CS CGGG R V C + + C A +P + CN PC
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCV-------YQLQNGTHVATRPLYCPGPRPAAVQS 915
+RW S C++ G TCV + G L P P P S
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMS 863
Query: 916 C-----------EGQDCLSIW--------EASEWS----QCSASCGKGVWKRTVACTNS- 951
C G+ S W A W+ CS SCG+G+ + C +S
Sbjct: 864 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 923
Query: 952 ------QGKCDASTRPRA-EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVT 1004
+ C +++P + E C+ W+ + CS +CG+G+ R++ C
Sbjct: 924 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHG 982
Query: 1005 GRHGSE------CPALSKPAPYRQCYQEVCNDR 1031
G E C L +P P C E C R
Sbjct: 983 EDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 1015
Score = 30.8 bits (68), Expect = 7.3
Identities = 28/90 (31%), Positives = 33/90 (36%), Gaps = 17/90 (18%)
Query: 799 DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
D + W W CSV CG G +R +C PQA P P C
Sbjct: 1071 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLG--------------PQAQAPVP-ADFCQ- 1114
Query: 859 HPCQSRWVAGPWS-PCSATCEKGFQHREVT 887
H + V G W+ PC G QH E T
Sbjct: 1115 HLPKPVTVRGCWAGPCVGQGACGRQHLEPT 1144
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 341 bits (875), Expect = 2e-93
Identities = 290/948 (30%), Positives = 396/948 (41%), Gaps = 142/948 (14%)
Query: 208 KKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNM 267
+ P+ G + R+RR A + +E LV D+ Q H E +R++LT +N+ +
Sbjct: 59 RPPSPGFQRQRQRQRRAAGGILH---LELLVAVGPDVFQAH-QEDTERYVLTNLNIGAEL 114
Query: 268 FQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVP 327
+ SLG + + + K+V+L + +I + SL S C W P
Sbjct: 115 LRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTIN-----------P 163
Query: 328 GGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTI 387
DP D +++TR D + D G+ LGG CS C++ ED G +L TI
Sbjct: 164 EDDTDPGHADLVLYITRFDLEL-PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTI 222
Query: 388 AHELGHNLGMNHDD-DHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVST 446
AHE+GH+ G+ HD S C H+M+ + R + L+WS CSR L + L + +
Sbjct: 223 AHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR--AGLAWSPCSRRQLLSLLSAGRAR 280
Query: 447 CLLVTDPRSQ--HTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHL-MCAGLWCLV 502
C+ PR Q P PG++YSANEQC++ FG A C EHL MC L C
Sbjct: 281 CVW-DPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHT 339
Query: 503 E--GDTSCKTKLDPPLDGTECGADKWCRAGEC---VSKTPIPEHVDGDWSPWGAWSMCSR 557
+ +SC L P LDGTECG +KWC G C V TPI V G WS WG S CSR
Sbjct: 340 DPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAA-VHGRWSSWGPRSPCSR 398
Query: 558 TCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD---- 613
+CG G R+R+C+NP P GG C GA ++ +C C K F QQC D
Sbjct: 399 SCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPL 458
Query: 614 RLSPKKK-----GLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPC---GPYE--- 662
R SP G D C C +G+ + D LDGT C GP E
Sbjct: 459 RSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGT 518
Query: 663 TDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARG----------- 711
LCV G C+ GCDG + S DRC VC GD TC KG F+ R
Sbjct: 519 LSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP 578
Query: 712 --TALKDSGKGSINSDWKIELPGEFQIAG-------TT---------VRY------VRRG 747
T++ + + + + + G + +AG TT V Y R
Sbjct: 579 NLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLP 638
Query: 748 LWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHS 807
E+I GP + + V + ++YG T P Q +P + W +
Sbjct: 639 RLEEIRIWGPLQEDADIQVYRRYGEEYG---NLTRPDITFTYFQPKPRQ------AWVWA 689
Query: 808 GWEG-CSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWV 866
G CSV CG G R SC K LV C + +P C L PC W
Sbjct: 690 AVRGPCSVSCGAGLRWVNYSCLDQARK--ELVETVQCQGSQQPPAWPEACVLEPCPPYWA 747
Query: 867 AGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC--PGPRPA-AVQSCEGQDCLS 923
G + PCSA+C G + R V CV + Q P C +PA A+++C Q C +
Sbjct: 748 VGDFGPCSASCGGGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA 806
Query: 924 IWEASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDYSGCY 974
WE SE S C+++ G G+ C ++G + A E C S
Sbjct: 807 RWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPP 866
Query: 975 EW-------------------KTGD-----WS----TCSSTCGKGLQSRVVQCMHKVTGR 1006
W +TG W+ +CS +CG+GL CM
Sbjct: 867 GWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRV 926
Query: 1007 HGSE--CPALSKPAPYRQCYQEV-CNDRINANTITSPRLAALTYKCTR 1051
E C SKP R+ Q V C R +LAA + C R
Sbjct: 927 PVQEELCGLASKPGSRREVCQAVPCPAR------WQYKLAACSVSCGR 968
Score = 101 bits (251), Expect = 4e-21
Identities = 70/240 (29%), Positives = 95/240 (39%), Gaps = 19/240 (7%)
Query: 803 IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
+WT + CSV CG G C + V + C AS+P + C PC
Sbjct: 896 VWTPAAGS-CSVSCGRGLMELRFLCMDSALRVP--VQEELCGLASKPGSRREVCQAVPCP 952
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCV--YQLQNGTHVATRPLYCPG-PRPAAVQSCEGQ 919
+RW + CS +C +G R + C + +G + C G PRP ++C +
Sbjct: 953 ARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQCQGLPRPEPQEACSLE 1010
Query: 920 DCLSIWEASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDY 970
C W+ CSASCG G +R+VAC + C A RP A C
Sbjct: 1011 PCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIA 1070
Query: 971 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCM--HKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Y W G W CS +CG G+Q R C+ C L KP R C+ C
Sbjct: 1071 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 77.4 bits (189), Expect = 7e-14
Identities = 67/273 (24%), Positives = 96/273 (35%), Gaps = 48/273 (17%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQ-ASRPEPQVRRCNLHPCQ 862
W + CS CGGG R V C + + C A +P + CN PC
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCV-------YQLQNGTHVATRPLYCPGPRPAAVQS 915
+RW S C++ G TCV + G L P P P S
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMS 863
Query: 916 C-----------EGQDCLSIW--------EASEWS----QCSASCGKGVWKRTVACTNS- 951
C G+ S W A W+ CS SCG+G+ + C +S
Sbjct: 864 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 923
Query: 952 ------QGKCDASTRPRA-EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVT 1004
+ C +++P + E C+ W+ + CS +CG+G+ R++ C
Sbjct: 924 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHG 982
Query: 1005 GRHGSE------CPALSKPAPYRQCYQEVCNDR 1031
G E C L +P P C E C R
Sbjct: 983 EDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 1015
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 338 bits (866), Expect = 2e-92
Identities = 274/869 (31%), Positives = 377/869 (43%), Gaps = 141/869 (16%)
Query: 8 PPLVLPV---------LLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPG 58
P L+LP+ LLLL+ L P + E + V P+ ++ LP +
Sbjct: 22 PCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEI----VFPEKLNGSVLPGSGA 77
Query: 59 PRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRR 118
P R LL L AFG L L+L +D G V+ G A
Sbjct: 78 PAR-------------------LLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPEL 118
Query: 119 GRPAELCFY-SGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPL-----NNSQGP 172
AE Y +G + G P S+ SL G G L+G++Q ++ +QPL N++ GP
Sbjct: 119 LGGAEPGTYLTGTINGDPESVASLHWDG--GALLGVLQYRGAELHLQPLEGGTPNSAGGP 176
Query: 173 FSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEH 232
+ H++RRK SP A Q P +C V K G PS R RR +
Sbjct: 177 GA---HILRRK-----SP-ASGQGP--MCNV-----KAPLGSPSP--RPRRAKRFASLSR 218
Query: 233 TVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPA 292
VETLVVAD M +HGA +R++LTVM F+H S+ +++ VT+LV+L
Sbjct: 219 FVETLVVADDKMAAFHGA-GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEE 277
Query: 293 KLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKD 352
+G ++L SFC WQ R L + DP D A+ TR D C
Sbjct: 278 GPQVGPSAAQTLRSFCAWQ-------RGLNTPE----DSDPDHFDTAILFTRQDLC--GV 324
Query: 353 EPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDD------HSSC 406
CDT+G+A +G VC R C + ED+GL AFT AHELGH M HD+ +
Sbjct: 325 STCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPL 384
Query: 407 AGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLP 466
+ H+M+ V + WS CS + +FL + CLL + + + LP P
Sbjct: 385 STSRHVMAP--VMAHVDPEEPWSPCSARFITDFLDNGYGHCLL---DKPEAPLHLPVTFP 439
Query: 467 GMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCL--VEGDTSCKTKLDPPLDGTECGAD 524
G Y A+ QCQ+ FG ++ C + CA LWC + G C+TK P DGT CG
Sbjct: 440 GKDYDADRQCQLTFGPDSRHCPQLPP-PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA 498
Query: 525 KWCRAGECVSKTPIPEH---VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTH 581
+ C G C+ + + G W PWG W CSRTCG G +F R C P P GG +
Sbjct: 499 QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKY 558
Query: 582 CPGASVEHAVCENLPCPKGLP-SFRDQQCQAHDRLSPKKKGL---------LTAVVVDDK 631
C G C CP G +FR++QC A++ + K T V D+
Sbjct: 559 CEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQ 618
Query: 632 PCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGV 691
C+L C ++ RV+DGTPC P + +CV G+C GCD IIGS K D+C V
Sbjct: 619 -CKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMV 677
Query: 692 CSGDGKTCHLVKGDF--------------SHARGTALKDSGKGSINS--------DWKIE 729
C GDG C G F + A ++ G S D
Sbjct: 678 CGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYA 737
Query: 730 LPGEFQIAGTTVRYVRRG-----------LWEKISAKGPTKLPLHLMVLLF-HDQDYGIH 777
L GE+ + + V G E +S GP PL L VL+ + QD +
Sbjct: 738 LNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLR 797
Query: 778 YEYTVPVNRTAENQSEPEKPQDSLFIWTH 806
Y + VP + P P+ + W H
Sbjct: 798 YSFFVP-------RPTPSTPRPTPQDWLH 819
Score = 36.2 bits (82), Expect = 0.17
Identities = 45/188 (23%), Positives = 64/188 (34%), Gaps = 44/188 (23%)
Query: 869 PWSPCSAT-----CEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCE---GQD 920
PWSPCSA + G+ H C+ L P+ PG A + C+ G D
Sbjct: 403 PWSPCSARFITDFLDNGYGH----CL--LDKPEAPLHLPVTFPGKDYDADRQCQLTFGPD 456
Query: 921 ----------CLSIWEASEWS-QCSASCGKGVWKRTVACTNSQ----GKCDASTRPRAEE 965
C ++W + + W C +Q G+C +
Sbjct: 457 SRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC------LHMD 510
Query: 966 ACEDYS-----GCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY 1020
+D++ G W G W CS TCG G+Q C V G C + +
Sbjct: 511 QLQDFNIPQAGGWGPW--GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE--GRRTRF 566
Query: 1021 RQCYQEVC 1028
R C E C
Sbjct: 567 RSCNTEDC 574
Score = 33.9 bits (76), Expect = 0.87
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 8/55 (14%)
Query: 868 GPWSPCSATCEKGFQHREVTCVYQL-QNGTHVATRPLYCPGPRPAAVQSCEGQDC 921
GPW CS TC G Q C + +NG YC G R +SC +DC
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGK------YCEG-RRTRFRSCNTEDC 574
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 320 bits (821), Expect = 4e-87
Identities = 282/946 (29%), Positives = 383/946 (40%), Gaps = 169/946 (17%)
Query: 208 KKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNM 267
+ P+ G + R+RR A + +E LV D+ Q H E +R++LT +N+ +
Sbjct: 59 RPPSPGFQRQRQRQRRAAGGILH---LELLVAVGPDVFQAH-QEDTERYVLTNLNIGAEL 114
Query: 268 FQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVP 327
+ SLG + + + K+V+L + +I + SL S C W P
Sbjct: 115 LRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTIN-----------P 163
Query: 328 GGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTI 387
DP D +++TR D + D G+ LGG CS C++ ED G +L TI
Sbjct: 164 EDDTDPGHADLVLYITRFDLEL-PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTI 222
Query: 388 AHELGHNLGMNHDD-DHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVST 446
AHE+GH+ G+ HD S C H+M+ + R + L+WS CSR L + L
Sbjct: 223 AHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR--AGLAWSPCSRRQLLSLL------ 274
Query: 447 CLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHL-MCAGLWCLVE- 503
SANEQC++ FG A C EHL MC L C +
Sbjct: 275 ------------------------SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDP 310
Query: 504 -GDTSCKTKLDPPLDGTECGADKWCRAGEC---VSKTPIPEHVDGDWSPWGAWSMCSRTC 559
+SC L P LDGTECG +KWC G C V TPI V G WS WG S CSR+C
Sbjct: 311 LDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAA-VHGRWSSWGPRSPCSRSC 369
Query: 560 GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD----RL 615
G G R+R+C+NP P GG C GA ++ +C C K F QQC D R
Sbjct: 370 GGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRS 429
Query: 616 SPKKK-----GLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPC---GPYE---TD 664
SP G D C C +G+ + D LDGT C GP E
Sbjct: 430 SPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS 489
Query: 665 LCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARG------------- 711
LCV G C+ GCDG + S DRC VC GD TC KG F+ R
Sbjct: 490 LCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNL 549
Query: 712 TALKDSGKGSINSDWKIELPGEFQIAG-------TT---------VRY------VRRGLW 749
T++ + + + + + G + +AG TT V Y R
Sbjct: 550 TSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRL 609
Query: 750 EKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGW 809
E+I GP + + V + ++YG T P Q +P + W +
Sbjct: 610 EEIRIWGPLQEDADIQVYRRYGEEYG---NLTRPDITFTYFQPKPRQ------AWVWAAV 660
Query: 810 EG-CSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAG 868
G CSV CG G R SC K LV C + +P C L PC W G
Sbjct: 661 RGPCSVSCGAGLRWVNYSCLDQARK--ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG 718
Query: 869 PWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC--PGPRPA-AVQSCEGQDCLSIW 925
+ PCSA+C G + R V CV + Q P C +PA A+++C Q C + W
Sbjct: 719 DFGPCSASCGGGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARW 777
Query: 926 EASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDYSGCYEW 976
E SE S C+++ G G+ C ++G + A E C S W
Sbjct: 778 EVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGW 837
Query: 977 -------------------KTGD-----WS----TCSSTCGKGLQSRVVQCMHKVTGRHG 1008
+TG W+ +CS +CG+GL CM
Sbjct: 838 GHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPV 897
Query: 1009 SE--CPALSKPAPYRQCYQEV-CNDRINANTITSPRLAALTYKCTR 1051
E C SKP R+ Q V C R +LAA + C R
Sbjct: 898 QEELCGLASKPGSRREVCQAVPCPAR------WQYKLAACSVSCGR 937
Score = 101 bits (251), Expect = 4e-21
Identities = 70/240 (29%), Positives = 95/240 (39%), Gaps = 19/240 (7%)
Query: 803 IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
+WT + CSV CG G C + V + C AS+P + C PC
Sbjct: 865 VWTPAAGS-CSVSCGRGLMELRFLCMDSALRVP--VQEELCGLASKPGSRREVCQAVPCP 921
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCV--YQLQNGTHVATRPLYCPG-PRPAAVQSCEGQ 919
+RW + CS +C +G R + C + +G + C G PRP ++C +
Sbjct: 922 ARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQCQGLPRPEPQEACSLE 979
Query: 920 DCLSIWEASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDY 970
C W+ CSASCG G +R+VAC + C A RP A C
Sbjct: 980 PCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIA 1039
Query: 971 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCM--HKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Y W G W CS +CG G+Q R C+ C L KP R C+ C
Sbjct: 1040 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 77.4 bits (189), Expect = 7e-14
Identities = 67/273 (24%), Positives = 96/273 (35%), Gaps = 48/273 (17%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQ-ASRPEPQVRRCNLHPCQ 862
W + CS CGGG R V C + + C A +P + CN PC
Sbjct: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCV-------YQLQNGTHVATRPLYCPGPRPAAVQS 915
+RW S C++ G TCV + G L P P P S
Sbjct: 775 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMS 832
Query: 916 C-----------EGQDCLSIW--------EASEWS----QCSASCGKGVWKRTVACTNS- 951
C G+ S W A W+ CS SCG+G+ + C +S
Sbjct: 833 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 892
Query: 952 ------QGKCDASTRPRA-EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVT 1004
+ C +++P + E C+ W+ + CS +CG+G+ R++ C
Sbjct: 893 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHG 951
Query: 1005 GRHGSE------CPALSKPAPYRQCYQEVCNDR 1031
G E C L +P P C E C R
Sbjct: 952 EDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 984
Score = 30.8 bits (68), Expect = 7.3
Identities = 28/90 (31%), Positives = 33/90 (36%), Gaps = 17/90 (18%)
Query: 799 DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
D + W W CSV CG G +R +C PQA P P C
Sbjct: 1040 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLG--------------PQAQAPVP-ADFCQ- 1083
Query: 859 HPCQSRWVAGPWS-PCSATCEKGFQHREVT 887
H + V G W+ PC G QH E T
Sbjct: 1084 HLPKPVTVRGCWAGPCVGQGACGRQHLEPT 1113
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 300 bits (767), Expect = 6e-81
Identities = 182/521 (34%), Positives = 243/521 (46%), Gaps = 50/521 (9%)
Query: 534 SKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCE 593
S P W PW WS CSRTCG G FR+R C + GG+ C G + H C
Sbjct: 17 SSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCR 75
Query: 594 NLPCPKGLPSFRDQQCQAHD--RLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADR 651
CP G FR +QC D ++ L +K CEL C P G+ +
Sbjct: 76 TESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREA 134
Query: 652 VLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF-SHAR 710
V+DGTPC P + D+CV G C+ +GCD + S+ +ED+C C GDG TC+ V G F ++
Sbjct: 135 VVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDL 194
Query: 711 GTALKD-SGKGSINSDWKIELPGEFQIAGTTVRYVRRG----LWEKISAKGPTKLPLHLM 765
A+K+ G+ +N W IE A T + Y R E++ A+GPT PL ++
Sbjct: 195 SRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPL-VI 253
Query: 766 VLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIV 825
L+ + + G+HYEY +P+ R + F W+H W CS +CGGG + +V
Sbjct: 254 ELISQEPNPGVHYEYHLPLRRPSPG-----------FSWSHGSWSDCSAECGGGHQSRLV 302
Query: 826 SCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC--QSRWVAGPWSPCSATCEKGFQH 883
CT D C + RP + R CNLHPC RW AGPW+PCSA+C G Q
Sbjct: 303 FCT----IDHEAYPDHMCQRQPRPADR-RSCNLHPCPETKRWKAGPWAPCSASCGGGSQS 357
Query: 884 REVTCVYQLQNGTHVATRPLYCPG--PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGV 941
R V C+ G A C G +P A+Q+C Q C + W W +CS SCG GV
Sbjct: 358 RSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECSVSCGVGV 416
Query: 942 WKRTVACTNSQGK------CDASTRPRAEEACEDYSGC-----YEWKTGDWSTCSSTCGK 990
KR+V C +G C RP E C + C W G W CS +C
Sbjct: 417 RKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV-HEDCPLLSDQAWHVGTWGLCSKSCSS 475
Query: 991 GLQSRVVQCMHKVTGRHGSECPAL--SKPAPYRQCYQEVCN 1029
G + R V C S C +L SKP C + C+
Sbjct: 476 GTRRRQVICAIGPP----SHCGSLQHSKPVDVEPCNTQPCH 512
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 247 bits (631), Expect = 4e-65
Identities = 171/609 (28%), Positives = 244/609 (40%), Gaps = 125/609 (20%)
Query: 540 EHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK 599
E DG+W WG WS CSRTCG GA + R+C G +C G ++ + C N CP
Sbjct: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPP 125
Query: 600 GLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDK--PCELYCSPLGKESPLLVADRVLDGTP 657
FR QQC A++ + + +D PC L C G+ + +A +VLDGT
Sbjct: 126 DAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
Query: 658 CGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF-SH-------- 708
C D+C+ G CQ +GCD +GS AKED CGVC+GDG TC LV+G SH
Sbjct: 186 CNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREE 245
Query: 709 --------ARGTALKDSGKGSI----------NSDWKIELPGEFQIAGTTVRYVRRGLWE 750
+R + G + + PG F + TTV + R +
Sbjct: 246 NVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQ 305
Query: 751 KISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWE 810
GP +D + + + P++ W + +
Sbjct: 306 TFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQ----------------WRQTDFF 349
Query: 811 GCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC---PQASRPEPQVRRCNLHPCQS---- 863
C+V CGGG + C I + +V D C P+ +P+P+++ C++ PC S
Sbjct: 350 PCTVTCGGGYQLNSAECVDI--RLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGF 407
Query: 864 -------------RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP-GPR 909
RW PW+ CS +C G Q R CV + +G + C P+
Sbjct: 408 KEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPK 467
Query: 910 PAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEE 965
P +Q+C DC W A EWSQC+ +CG+G+ R V C N +G+ C+ + +E
Sbjct: 468 PKVMQTCNLFDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKE 526
Query: 966 ACEDYSGCYEWKTGD-------------------------------WSTCSSTCGKGLQS 994
C CY+ K WS CS+TCG G+Q
Sbjct: 527 ECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQV 586
Query: 995 RVVQCMHKVTGRH------GSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYK 1048
R V+C +T EC P R C E C++ SP L
Sbjct: 587 REVKCRVLLTFTQTETELPEEECEGPKLPTE-RPCLLEACDE--------SPASRELDIP 637
Query: 1049 CTRDQWTVY 1057
D T Y
Sbjct: 638 LPEDSETTY 646
Score = 150 bits (378), Expect = 8e-36
Identities = 100/319 (31%), Positives = 135/319 (42%), Gaps = 41/319 (12%)
Query: 777 HYEYTVPVNRTAENQSEP--EKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKT 834
H +Y + T N ++P E P F W W CS CG R + + V
Sbjct: 1400 HKKYILQATNTRTNSNDPTGEPPPQEPF-WEPGNWSHCSATCGHLGAR--IQRPQCVMAN 1456
Query: 835 TTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQN 894
V+++ C +P CN+ C +RW WS CS +C +G+ R+VTC N
Sbjct: 1457 GQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKAN 1516
Query: 895 GTHVATRPLYC-PGPRPAAVQSCEGQDCLSIWEASEWSQCSASC-GKGV--WKRTVAC-- 948
GT P C P RP + C G C+ WE ++C C G+ V +R AC
Sbjct: 1517 GTVQVVSPRACAPKDRPLGRKPCFGHPCVQ-WEPG--NRCPGRCMGRAVRMQQRHTACQH 1573
Query: 949 TNSQGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMH-----KV 1003
+S CD RP C + W TG W C++ CG+G QSR V C+H V
Sbjct: 1574 NSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPV 1633
Query: 1004 TGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIRE 1063
RH C KP +R C C DR CT T YC ++
Sbjct: 1634 AKRH---CVQKKKPISWRHCLGPSC-DR----------------DCT--DTTHYCMFVKH 1671
Query: 1064 KNLCQDMRWYQRCCQTCRD 1082
NLC R+ QRCCQ+C++
Sbjct: 1672 LNLCSLDRYKQRCCQSCQE 1690
Score = 138 bits (347), Expect = 3e-32
Identities = 77/216 (35%), Positives = 99/216 (45%), Gaps = 21/216 (9%)
Query: 797 PQDS--LFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVR 854
P+DS + W ++G+ C+ C GG + I C I + T VNDS C RP +
Sbjct: 639 PEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQT--VNDSLCDMVHRPPAMSQ 696
Query: 855 RCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ 914
CN PC RW G W PCSATC G Q R+V C++ P C +P A+Q
Sbjct: 697 ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP----GETPAPPEECRDEKPHALQ 752
Query: 915 SCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACE-----D 969
+C DC W EW QCS +CG G R V C Q D S ++E C+
Sbjct: 753 ACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC--RQLLTDGSFLNLSDELCQGPKASS 810
Query: 970 YSGCY------EWKTGDWSTCSSTCGKGLQSRVVQC 999
+ C GDWS CS +CG G+Q R C
Sbjct: 811 HKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 92.4 bits (228), Expect = 2e-18
Identities = 62/224 (27%), Positives = 89/224 (39%), Gaps = 33/224 (14%)
Query: 809 WEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQV---RRCNLHPCQSR- 864
W CS CG G + V C ++ T T +++ P+ P++ R C L C
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQT---ETELPEEECEGPKLPTERPCLLEACDESP 629
Query: 865 ------------------WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP 906
W ++PC+ATC G Q C++ +Q V
Sbjct: 630 ASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH-IQTQQTVNDSLCDMV 688
Query: 907 GPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDA------STR 960
PA Q+C + C W W CSA+CG G+ R V C + G+ A +
Sbjct: 689 HRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRDEK 747
Query: 961 PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVT 1004
P A +AC + W +W CS TCG G Q+R V C +T
Sbjct: 748 PHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLT 791
Score = 85.5 bits (210), Expect = 3e-16
Identities = 74/279 (26%), Positives = 102/279 (36%), Gaps = 55/279 (19%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRI-------VNKTTTLVNDSDC--------PQASR 848
W W C+V CG G R +V C N L +C P+
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
Query: 849 P----------EPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQ-NGTH 897
P ++ + + ++ PWS CS TC G Q REV C L T
Sbjct: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
Query: 898 VATRPLYCPGP-----RPAAVQSC--------------EGQDCLSIWEASEWSQCSASCG 938
C GP RP +++C E + WE + ++ C+A+C
Sbjct: 602 TELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
Query: 939 KGVWKRTVACTNSQGK-------CDASTRPRA-EEACEDYSGCYEWKTGDWSTCSSTCGK 990
G + C + Q + CD RP A +AC W G W CS+TCG
Sbjct: 662 GGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGV 721
Query: 991 GLQSRVVQCMHK-VTGRHGSECPALSKPAPYRQCYQEVC 1028
G+Q+R V C+H T EC KP + C Q C
Sbjct: 722 GIQTRDVYCLHPGETPAPPEECRD-EKPHALQACNQFDC 759
Score = 37.4 bits (85), Expect = 0.078
Identities = 21/62 (33%), Positives = 25/62 (40%), Gaps = 2/62 (3%)
Query: 550 GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAV--CENLPCPKGLPSFRDQ 607
G+W CS TCG G + R C +P P HA+ C CP G Q
Sbjct: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
Query: 608 QC 609
QC
Sbjct: 770 QC 771
Score = 34.7 bits (78), Expect = 0.51
Identities = 39/148 (26%), Positives = 52/148 (35%), Gaps = 40/148 (27%)
Query: 546 WSPWGAWSMCSRTCG-TGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP-KGLPS 603
W P G WS CS TCG GAR ++ +C G V A+C++L P G
Sbjct: 1428 WEP-GNWSHCSATCGHLGARIQRPQC---------VMANGQEVSEALCDHLQKPLAGFEP 1477
Query: 604 FRDQQCQA------------------HDR--LSPKKKGLLTAVVVDDKPCELYCSPLGKE 643
+ C A H R + K T VV + C PLG++
Sbjct: 1478 CNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRK 1537
Query: 644 SPLLVADRVLDGTPCGPYETDLCVHGKC 671
G PC +E G+C
Sbjct: 1538 PCF--------GHPCVQWEPGNRCPGRC 1557
Score = 33.5 bits (75), Expect = 1.1
Identities = 39/155 (25%), Positives = 55/155 (35%), Gaps = 27/155 (17%)
Query: 466 PGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADK 525
PG H +QC G R + C L D S D G + + K
Sbjct: 761 PGWHIEEWQQCSRTCGGGTQNRR----VTCRQLLT----DGSFLNLSDELCQGPKASSHK 812
Query: 526 WCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGA 585
C +C P H+ G WS CS +CG G + R++ C G P
Sbjct: 813 SCARTDC------PPHL-----AVGDWSKCSVSCGVGIQRRKQVCQR--LAAKGRRIP-- 857
Query: 586 SVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKK 620
+ +C +LP GLP R Q ++ + K
Sbjct: 858 -LSEMMCRDLP---GLPLVRSCQMPECSKIKSEMK 888
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 243 bits (619), Expect = 9e-64
Identities = 174/589 (29%), Positives = 243/589 (41%), Gaps = 127/589 (21%)
Query: 540 EHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK 599
E DG W WG WS CSRTCG GA + R+C + C G ++ + C N+ CP
Sbjct: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPP 83
Query: 600 GLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD--KPCELYCSPLGKESPLLVADRVLDGTP 657
FR QQC AH+ + + V +D PC L C G + +A +VLDGT
Sbjct: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
Query: 658 CGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDS 717
C D+C+ G CQ +GCD +GS KED CGVC+GDG TC LV+G + K
Sbjct: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY--------KSQ 195
Query: 718 GKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIH 777
+ + D + +P Y R + ++ KGP L L L + +
Sbjct: 196 LSATKSDDTVVAIP-----------YGSRHI--RLVLKGPDHLYLETKTLQGTKGENSLS 242
Query: 778 YEYTVPV-NRTAENQSEPEK-------PQDSLFI------------------------WT 805
T V N + + Q P+K P + FI W
Sbjct: 243 STGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWR 302
Query: 806 HSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC---PQASRPEPQVRRCNLHPCQ 862
+ + CS CGGG + T C + ++ +V D C P+ +P+P+++ CNL PC
Sbjct: 303 ETDFFPCSATCGGGYQLTSAECYDL--RSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 863 S-----------------RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC 905
+ RW A PW+ CS++C G Q R V+CV + G + C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 906 P-GPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTR 960
P+ Q C DC W A EWS C+ +CG+G+ R V C + +G C T+
Sbjct: 421 MYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
Query: 961 PRAEEACEDYSGCYEWK-------------------------------TGDWSTCSSTCG 989
P +E C + CY+ K WS C+ TCG
Sbjct: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
Query: 990 KGLQSRVVQCM------HKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
G Q R+V+C V EC KPA R CY C+ I
Sbjct: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPASQRACYAGPCSGEI 587
Score = 161 bits (408), Expect = 3e-39
Identities = 90/264 (34%), Positives = 127/264 (48%), Gaps = 22/264 (8%)
Query: 799 DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
D L+ W + G+ CS CGGG + +VSC +T ++ C + RP ++ CNL
Sbjct: 606 DELYDWEYEGFTKCSESCGGGVQEAVVSCLN--KQTREPAEENLCVTSRRPPQLLKSCNL 663
Query: 859 HPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQL---QNGTHVATRPLYCPGPRPAAVQS 915
PC +RW G WSPCS TC G Q R+V C + L N T + L C P+P+ VQ+
Sbjct: 664 DPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADEL-CRQPKPSTVQA 722
Query: 916 CEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----------CDASTRPRAEE 965
C +C W ++W CS +CG GV KR V C C AS +P ++
Sbjct: 723 CNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQ 781
Query: 966 ACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKV-----TGRHGSECPALSKPAPY 1020
AC+ EW DW+ CS++CG+G Q+R C + T + + CP L +
Sbjct: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
Query: 1021 RQCYQEVCNDRINANTITSPRLAA 1044
R C C +T SP +AA
Sbjct: 842 RPCMLATCARPGRPSTKHSPHIAA 865
Score = 128 bits (322), Expect = 3e-29
Identities = 92/312 (29%), Positives = 132/312 (42%), Gaps = 42/312 (13%)
Query: 788 AENQSEPEKPQDSLFI----WTHSGWEGCSVQCGG-GERRTIVSCTRIVNKTTTLVNDSD 842
A+N++ + SL I W+ CS CG G ++ + C ++N T VN +
Sbjct: 1471 AQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTE--VNPAH 1526
Query: 843 CPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRP 902
C RP Q CN C SRW+ WS C+ +C G Q R VTC +G
Sbjct: 1527 CAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSN 1586
Query: 903 LYCP--GPRPAAVQSCEGQDCLSIWEASEWSQCSASC---GKGVWKRTVACTNSQG---- 953
C RP Q+C Q C+ W S W QC+ C V R V C G
Sbjct: 1587 DMCTQVAKRPVDTQACNQQLCVE-WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLP 1645
Query: 954 --KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGK-GLQSRVVQCMHKVTGRHGSE 1010
+C A RP + + C + W+ W+ C++TCG G QSR V+C+H T + E
Sbjct: 1646 SEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPE 1705
Query: 1011 --CPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQ 1068
C +PA +++C C + +T T YC +++ LCQ
Sbjct: 1706 HLCSWGPRPANWQRCNITPCENMECRDT------------------TRYCEKVKQLKLCQ 1747
Query: 1069 DMRWYQRCCQTC 1080
++ RCC TC
Sbjct: 1748 LSQFKSRCCGTC 1759
Score = 94.7 bits (234), Expect = 4e-19
Identities = 69/262 (26%), Positives = 102/262 (38%), Gaps = 46/262 (17%)
Query: 809 WEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRR-CNLHPCQSR--- 864
W C+V CG G + IV C +++ + V D + P+P +R C PC
Sbjct: 531 WSACTVTCGVGTQVRIVRC-QVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE 589
Query: 865 ---------------------WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPL 903
W ++ CS +C G Q V+C L T
Sbjct: 590 FNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC---LNKQTREPAEEN 646
Query: 904 YCPGPR--PAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDAST-- 959
C R P ++SC C + WE +WS CS +CG G+ R V C++ + T
Sbjct: 647 LCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVI 706
Query: 960 ---------RPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE 1010
+P +AC ++ W W CS TCG G+Q R V C ++ E
Sbjct: 707 LADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
Query: 1011 CP----ALSKPAPYRQCYQEVC 1028
P + SKPA + C ++ C
Sbjct: 767 LPETFCSASKPACQQACKKDDC 788
Score = 92.4 bits (228), Expect = 2e-18
Identities = 84/358 (23%), Positives = 134/358 (37%), Gaps = 84/358 (23%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRI-VNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
W + W CS CGGG + VSC + T V + C + P + CN+ C
Sbjct: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM-PIAQPCNIFDCP 438
Query: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTH----------------VATRPLYCP 906
+W+A WSPC+ TC +G ++R V C+ G H + P Y P
Sbjct: 439 -KWLAQEWSPCTVTCGQGLRYRVVLCIDH--RGMHTGGCSPKTKPHIKEECIVPTPCYKP 495
Query: 907 GPR-------PAAVQSCEGQDCLSIWEASE-----WSQCSASCGKGVWKRTVAC----TN 950
+ P Q+ E ++ ++ E WS C+ +CG G R V C +
Sbjct: 496 KEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSF 555
Query: 951 SQGKCDA------STRPRAEEAC------------------------EDYSGCYEWKTGD 980
SQ D +P ++ AC +D+ Y+W+
Sbjct: 556 SQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEG 615
Query: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAP---YRQCYQEVCNDRINANTI 1037
++ CS +CG G+Q VV C++K T E ++ P + C + C R
Sbjct: 616 FTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKW 675
Query: 1038 TSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS 1095
+ L TRD V+C + + + + + C RQP P++
Sbjct: 676 SPCSLTCGVGLQTRD---VFCSHLLSREMNETVILADELC-----------RQPKPST 719
Score = 36.6 bits (83), Expect = 0.13
Identities = 30/122 (24%), Positives = 43/122 (35%), Gaps = 7/122 (5%)
Query: 796 KPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNK-TTTLVNDSDCPQASRPEPQVR 854
K D W S W CS CG G + C +++ +T+VN + CP P
Sbjct: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCP------PLPF 837
Query: 855 RCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ 914
++ PC A P P + R+V + Q H P+ A V
Sbjct: 838 SSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVL 897
Query: 915 SC 916
C
Sbjct: 898 RC 899
Score = 30.8 bits (68), Expect = 7.3
Identities = 23/74 (31%), Positives = 28/74 (37%), Gaps = 16/74 (21%)
Query: 505 DTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDG--------DWSPWGAWSMCS 556
D C L ++ T AD+ CR P P V W P W CS
Sbjct: 690 DVFCSHLLSREMNETVILADELCRQ-------PKPSTVQACNRFNCPPAWYP-AQWQPCS 741
Query: 557 RTCGTGARFRQRKC 570
RTCG G + R+ C
Sbjct: 742 RTCGGGVQKREVLC 755
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 226 bits (575), Expect = 1e-58
Identities = 152/497 (30%), Positives = 217/497 (43%), Gaps = 89/497 (17%)
Query: 540 EHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK 599
E DG W WG WS CSRTCG GA + R+C + C G ++ + C N+ CP
Sbjct: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPP 83
Query: 600 GLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD--KPCELYCSPLGKESPLLVADRVLDGTP 657
FR QQC AH+ + + V +D PC L C G + +A +VLDGT
Sbjct: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
Query: 658 CGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDS 717
C D+C+ G CQ +GCD +GS KED CGVC+GDG TC LV+G + K
Sbjct: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY--------KSQ 195
Query: 718 GKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIH 777
+ + D + +P Y R + ++ KGP L L L + +
Sbjct: 196 LSATKSDDTVVAIP-----------YGSRHI--RLVLKGPDHLYLETKTLQGTKGENSLS 242
Query: 778 YEYTVPV-NRTAENQSEPEK-------PQDSLFI------------------------WT 805
T V N + + Q P+K P + FI W
Sbjct: 243 STGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWR 302
Query: 806 HSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC---PQASRPEPQVRRCNLHPCQ 862
+ + CS CGGG + T C + ++ +V D C P+ +P+P+++ CNL PC
Sbjct: 303 ETDFFPCSATCGGGYQLTSAECYDL--RSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 863 S-----------------RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC 905
+ RW A PW+ CS++C G Q R V+CV + G + C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 906 P-GPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTR 960
P+ Q C DC W A EWS C+ +CG+G+ R V C + +G C T+
Sbjct: 421 MYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
Query: 961 PRAEEACEDYSGCYEWK 977
P +E C + CY+ K
Sbjct: 480 PHIKEECIVPTPCYKPK 496
Score = 88.6 bits (218), Expect = 3e-17
Identities = 60/197 (30%), Positives = 85/197 (43%), Gaps = 39/197 (19%)
Query: 860 PCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP------GPRPAAV 913
P RW + PCSATC G+Q C Y L++ VA + YC P+P +
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAEC-YDLRSNRVVADQ--YCHYYPENIKPKPK-L 351
Query: 914 QSCEGQDC-----------------LSIWEASEWSQCSASCGKGVWKRTVACTNS----- 951
Q C C L WEA+ W+ CS+SCG G+ R V+C
Sbjct: 352 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH 411
Query: 952 -----QGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR 1006
+ KC + + + C + C +W +WS C+ TCG+GL+ RVV C+ G
Sbjct: 412 VTSVEEWKCMYTPKMPIAQPCNIFD-CPKWLAQEWSPCTVTCGQGLRYRVVLCIDH-RGM 469
Query: 1007 HGSECPALSKPAPYRQC 1023
H C +KP +C
Sbjct: 470 HTGGCSPKTKPHIKEEC 486
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 224 bits (571), Expect = 3e-58
Identities = 161/552 (29%), Positives = 219/552 (39%), Gaps = 112/552 (20%)
Query: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT-----AVVVDDKPCELY 636
C G S + C PCP P R QC A + S + G L V + CEL
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFN--SQEFMGQLYQWEPFTEVQGSQRCELN 421
Query: 637 CSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDG 696
C P G + ++V DGT C P D+CV G+C GCDGI+GS + D CGVC GD
Sbjct: 422 CRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 697 KTCHLVKGDFSHARGT----------------------------ALKD-SGKGSINSDWK 727
TC LV G+ + G AL+ G+ IN +W
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
Query: 728 IELPGEFQIAGTTVRYVR----RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVP 783
++ PG ++ GT RY R G E +SA+GPT P+ + ++F +++ G+ Y+Y +
Sbjct: 542 VDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVY-MIFQEENPGVFYQYVIS 600
Query: 784 VNRTAENQSEPEKPQDSL------------------------------------------ 801
PE P L
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 802 -----FIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
W G CS CG G R I C I ++ +++ C +RP C
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLC--ISRESGEELDERSCAAGARPPASPEPC 718
Query: 857 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQS 915
+ PC W AG W+ CS +C G QHR++ C + G + P C PRP QS
Sbjct: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGS-SVPPERCGHLPRPNITQS 777
Query: 916 CEGQDCLSIWE-ASEWSQCSASCGKGVWKRTVACTNSQGK-------CDASTRPRAEEAC 967
C+ + C WE S WSQCS CG+G R V C + G +P + EAC
Sbjct: 778 CQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
Query: 968 EDYSGCYEWKTGDWST-CSSTCGKGLQSRVVQCM----------HKVTGRHGSECPALSK 1016
+ W DWS+ CS+ CG G+Q R V C+ + G CP S+
Sbjct: 837 DMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSR 896
Query: 1017 PAPYRQCYQEVC 1028
P R C C
Sbjct: 897 PPDMRACSLGPC 908
Score = 126 bits (317), Expect = 1e-28
Identities = 82/308 (26%), Positives = 122/308 (39%), Gaps = 47/308 (15%)
Query: 807 SGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWV 866
S W CSV+CG G+R V C V V++ +C P C++ PC + W
Sbjct: 790 SPWSQCSVRCGRGQRSRQVRC---VGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWF 846
Query: 867 AGPWSP-CSATCEKGFQHREVTCVYQLQNGTHVATRP----------LYCP-GPRPAAVQ 914
WS CSA C G Q R V C+ G+ A P CP G RP ++
Sbjct: 847 HSDWSSKCSAECGTGIQRRSVVCL-----GSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
Query: 915 SCEGQDCLSIWE--ASEWSQCSASCGKGVWKRTVACTNSQG---------KCDASTRPRA 963
+C C W W +CS+ CG G +R + C + G C RP A
Sbjct: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
Query: 964 EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQC 1023
+ C+ + W + WS CS +C G Q+R VQC+ + CP +P+ R C
Sbjct: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-STNQTLSTRCPPQLRPSRKRPC 1020
Query: 1024 YQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDF 1083
+ C+ R + S + +C ++ + LC + CC++C
Sbjct: 1021 NSQPCSQRPDDQCKDS---------------SPHCPLVVQARLCVYPYYTATCCRSCAHV 1065
Query: 1084 YANKMRQP 1091
+ P
Sbjct: 1066 LERSPQDP 1073
Score = 113 bits (282), Expect = 1e-24
Identities = 70/207 (33%), Positives = 94/207 (45%), Gaps = 17/207 (8%)
Query: 804 WTHSGWEG-CSVQCGGGERRTIVSCTRIVNKTTTLVNDS------DCPQASRPEPQVRRC 856
W HS W CS +CG G +R V C ++ CP SRP P +R C
Sbjct: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRP-PDMRAC 903
Query: 857 NLHPCQS--RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAV 913
+L PC+ RW GPW CS+ C G Q R++ CV +L +V T P C PRP A+
Sbjct: 904 SLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNV-TSPSNCSHLPRPPAL 962
Query: 914 QSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNS----QGKCDASTRPRAEEACED 969
Q C+GQ C W ++ WS CS SC G R V C ++ +C RP + C
Sbjct: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNS 1022
Query: 970 YSGCYEWKTGDWSTCSSTCGKGLQSRV 996
C + S C +Q+R+
Sbjct: 1023 -QPCSQRPDDQCKDSSPHCPLVVQARL 1048
Score = 81.6 bits (200), Expect = 4e-15
Identities = 43/126 (34%), Positives = 61/126 (48%), Gaps = 8/126 (6%)
Query: 797 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
P + + W W CS +CG G +R + C + + + S+C RP P ++ C
Sbjct: 907 PCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRP-PALQPC 965
Query: 857 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGP-RPAAVQS 915
CQ RW + PWSPCS +C+ G Q REV C L ++TR CP RP+ +
Sbjct: 966 QGQACQDRWFSTPWSPCSRSCQGGTQTREVQC---LSTNQTLSTR---CPPQLRPSRKRP 1019
Query: 916 CEGQDC 921
C Q C
Sbjct: 1020 CNSQPC 1025
Score = 52.4 bits (124), Expect = 2e-06
Identities = 94/398 (23%), Positives = 138/398 (34%), Gaps = 67/398 (16%)
Query: 524 DKWCRAGECVSKTPIPEHVDGDWSPW--GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTH 581
++ C AG +P P H W G W+ CSR+CG G + RQ +C G
Sbjct: 702 ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG----- 756
Query: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLG 641
G+SV C +LP P S + + C + SP + C + C G
Sbjct: 757 -GGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQ------------CSVRCG-RG 802
Query: 642 KESPLL---------VADRVLDGTPCGPYETDLCVHGKCQ--------KIGCDGIIGSAA 684
+ S + V+++ P P + C G C C G+
Sbjct: 803 QRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGI 862
Query: 685 KEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYV 744
+ R VC G G +G+ G + GS D + G + T R+
Sbjct: 863 QR-RSVVCLGSGAALGPGQGEAGAGTG---QSCPTGSRPPDMRACSLGPCE---RTWRWY 915
Query: 745 RRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRT---AENQSEPEKPQDSL 801
G W + S++ + ++ + G + T P N + +P + Q
Sbjct: 916 -TGPWGECSSECGSGTQRRDIICV---SKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971
Query: 802 FIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC 861
W + W CS C GG + V C +T + CP RP + R CN PC
Sbjct: 972 DRWFSTPWSPCSRSCQGGTQTREVQCL-----STNQTLSTRCPPQLRPS-RKRPCNSQPC 1025
Query: 862 QSRWVAGPWSPC---SATCEKGFQHREVTCVYQLQNGT 896
R P C S C Q R CVY T
Sbjct: 1026 SQR----PDDQCKDSSPHCPLVVQAR--LCVYPYYTAT 1057
Score = 41.2 bits (95), Expect = 0.005
Identities = 14/31 (45%), Positives = 18/31 (58%)
Query: 543 DGDWSPWGAWSMCSRTCGTGARFRQRKCDNP 573
+G W PW W+ CS+ CG G + R R C P
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 202 bits (514), Expect = 1e-51
Identities = 144/496 (29%), Positives = 197/496 (39%), Gaps = 101/496 (20%)
Query: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT-----AVVVDDKPCELY 636
C G S + C PCP P R QC A + S + G L V + CEL
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFN--SQEFMGQLYQWEPFTEVQGSQRCELN 421
Query: 637 CSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDG 696
C P G + ++V DGT C P D+CV G+C GCDGI+GS + D CGVC GD
Sbjct: 422 CRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 697 KTCHLVKGDFSHARGT----------------------------ALKD-SGKGSINSDWK 727
TC LV G+ + G AL+ G+ IN +W
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
Query: 728 IELPGEFQIAGTTVRYVR----RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVP 783
++ PG ++ GT RY R G E +SA+GPT P+ + ++F +++ G+ Y+Y +
Sbjct: 542 VDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVY-MIFQEENPGVFYQYVIS 600
Query: 784 VNRTAENQSEPEKPQDSL------------------------------------------ 801
PE P L
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 802 -----FIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
W G CS CG G R I C I ++ +++ C +RP C
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLC--ISRESGEELDERSCAAGARPPASPEPC 718
Query: 857 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQS 915
+ PC W AG W+ CS +C G QHR++ C + G + P C PRP QS
Sbjct: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGS-SVPPERCGHLPRPNITQS 777
Query: 916 CEGQDCLSIWE-ASEWSQCSASCGKGVWKRTVACTNSQGK-------CDASTRPRAEEAC 967
C+ + C WE S WSQCS CG+G R V C + G +P + EAC
Sbjct: 778 CQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
Query: 968 EDYSGCYEWKTGDWST 983
+ W DWS+
Sbjct: 837 DMGPCTTAWFHSDWSS 852
Score = 70.9 bits (172), Expect = 6e-12
Identities = 39/116 (33%), Positives = 53/116 (45%), Gaps = 12/116 (10%)
Query: 925 WEASEWSQCSASCGKGVWKRTVACTNSQG-------KCDASTRPRAE-EACEDYSGCYEW 976
W+ S CSASCGKGVW+ C + + C A RP A E C W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 977 KTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGS----ECPALSKPAPYRQCYQEVC 1028
+ G+W++CS +CG G Q R +QC + G S C L +P + C +C
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
Score = 41.2 bits (95), Expect = 0.005
Identities = 14/31 (45%), Positives = 18/31 (58%)
Query: 543 DGDWSPWGAWSMCSRTCGTGARFRQRKCDNP 573
+G W PW W+ CS+ CG G + R R C P
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 39.7 bits (91), Expect = 0.016
Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 8/88 (9%)
Query: 524 DKWCRAGECVSKTPIPEHVDGDWSPW--GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTH 581
++ C AG +P P H W G W+ CSR+CG G + RQ +C G
Sbjct: 702 ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG----- 756
Query: 582 CPGASVEHAVCENLPCPKGLPSFRDQQC 609
G+SV C +LP P S + + C
Sbjct: 757 -GGSSVPPERCGHLPRPNITQSCQLRLC 783
Score = 33.5 bits (75), Expect = 1.1
Identities = 13/27 (48%), Positives = 14/27 (51%)
Query: 544 GDWSPWGAWSMCSRTCGTGARFRQRKC 570
G W WS CS CG G R RQ +C
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRC 810
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 200 bits (509), Expect = 5e-51
Identities = 180/551 (32%), Positives = 251/551 (45%), Gaps = 63/551 (11%)
Query: 6 LLPPLVLPVLLLLVWGLDP-GTAVGDAAADVEVVLPWRVRPDD--------VHLPPLPAA 56
LLPP P L DP G +G A E +L VR D V A
Sbjct: 27 LLPPPPPPANARLAAAADPPGGPLGHGA---ERILAVPVRTDAQGRLVSHVVSAATSRAG 83
Query: 57 PGPRRRRRPRTP--PAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGA 114
RR RTP P PG L ++ FGRDL+L+LR + R ++ G +E G
Sbjct: 84 VRARRAAPVRTPSFPGGNEEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE 142
Query: 115 -ARRRGRPA-ELCFYSGRVLG-HPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNN--- 168
R P C Y G V G S V+LS C GL GLI++ +E+ I+PL
Sbjct: 143 KGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCD---GLAGLIRMEEEEFFIEPLEKGLA 199
Query: 169 SQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRL 228
+Q GR H++ R+ P S P+ L + + R E N+ R
Sbjct: 200 AQEAEQGRVHVVYRR----PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
Query: 229 TS-------EHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQV 281
+ ++ +E L+ D +VQ+HG E Q+++LT+MN+V ++ +SLG IN+ +
Sbjct: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
Query: 282 TKLVLLR--QRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
+++LL + + + IG+ + SLE+ C W YL Q P D D A
Sbjct: 316 VRIILLSYGKSMSLIEIGNPSQ-SLENVCRW--------AYL--QQKPDTGHD-EYHDHA 363
Query: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
+F+TR DF P G A + G+C R C L ++G + AF +AHE GH LGM H
Sbjct: 364 IFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
Query: 400 DDDHSSCAGRSHIMS--GEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQH 457
D + C + S V+ WS CS+ +L +L S CLL DP +
Sbjct: 419 DGQGNRCGDEVRLGSIMAPLVQAAF-HRFHWSRCSQQELSRYLHS--YDCLL-DDPFAHD 474
Query: 458 TVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHL-MCAGLWCL-VEGDTSCKTKLDPP 515
LP +LPG+HYS NEQC+ FG+ C C LWC + CKTK PP
Sbjct: 475 WPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPP 533
Query: 516 LDGTECGADKW 526
LDGT C K+
Sbjct: 534 LDGTMCAPGKF 544
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 181 bits (459), Expect = 3e-45
Identities = 145/510 (28%), Positives = 209/510 (40%), Gaps = 70/510 (13%)
Query: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDR---LSPKKKGLLTAVVVDDKPCELYCS 638
C GA ++ +C CP+ S R+ QC +++ + + A V ++ CEL C
Sbjct: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
Query: 639 PLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKT 698
+G + A++V+DGTPC T +CV G+C+ IGCD +GS D+CGVC GD
Sbjct: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
Query: 699 CHLVKGDFSHARGT----------------------------ALKD-SGKGSINSDWKIE 729
C +V G F HA + AL+ SG+ IN +W I+
Sbjct: 411 CQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID 470
Query: 730 LPGEFQIAGTTVRYVRRG-----LWEKISAKGPTKLPLHLMVLLFHDQ-DYGIHYEYTVP 783
PG+++ GT Y R E A+GPT L V + H Q + G+HYEY +
Sbjct: 471 RPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILD--VYMIHQQPNPGVHYEYVIM 528
Query: 784 VNRTAENQSEPEKPQDSLF---IWTHSGWEGCSVQCGGGE-----RRTIVSCTRIVNKTT 835
Q P + F + T + Q G E R + T
Sbjct: 529 GTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQT 588
Query: 836 TLVNDSDCPQASRPEPQVRRCNLHPCQSR---WVAGPWSPCSATCEKGFQHREVTCVYQL 892
V D RP+ V P +SR W + CS TC KG Q+ CV++
Sbjct: 589 FPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHR- 647
Query: 893 QNGTHVATRPLYCPG---PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVAC- 948
TH YC P P + C C + W+ EWS+CS +CG G+ R V C
Sbjct: 648 --STHEEAPESYCDSSMKPTPEE-EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCR 704
Query: 949 --------TNSQGKCDASTRPRAEEACEDYSGCYEWK-TGDWSTCSSTCGKGLQSRVVQC 999
T +C +P C+ C EW+ DW++CS CG G ++R V+C
Sbjct: 705 QVYANRSLTVQPYRCQHLEKPETTSTCQ-LKICSEWQIRTDWTSCSVPCGVGQRTRDVKC 763
Query: 1000 MHKVTG-RHGSECPALSKPAPYRQCYQEVC 1028
+ + EC +P C C
Sbjct: 764 VSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
Score = 124 bits (311), Expect = 5e-28
Identities = 80/285 (28%), Positives = 118/285 (41%), Gaps = 38/285 (13%)
Query: 809 WEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAG 868
W CSV CG G+R V C V+ +V+D +C RP + C++ PC W
Sbjct: 745 WTSCSVPCGVGQRTRDVKC---VSNIGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFLT 800
Query: 869 PWSP-CSATCEKGFQHREVTCVYQLQNGTHVATRPLY-CPGPRPAAVQSCEGQDCLSI-- 924
WS CSA C G + R V C+ HV++ PL C RPA C+ C
Sbjct: 801 EWSERCSAECGAGVRTRSVVCMTN-----HVSSLPLEGCGNNRPAEATPCDNGPCTGKVE 855
Query: 925 WEASEWSQCSASCGKGVWKRTVACTNSQG---------KCDASTRPRAEEACEDYSGCYE 975
W A WSQCS CG G +R V C +C +P ++++C +
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
Query: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINAN 1035
W + +WS CS +C G + R V+C+ + C KP C + C ++ N
Sbjct: 916 WFSTEWSMCSKSCQGGFRVREVRCLSD-DMTLSNLCDPQLKPEERESCNPQDCVPEVDEN 974
Query: 1036 TITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
+D++ C V+ + LC + CC +C
Sbjct: 975 --------------CKDKY-YNCNVVVQARLCVYNYYKTACCASC 1004
Score = 121 bits (303), Expect = 4e-27
Identities = 70/237 (29%), Positives = 102/237 (43%), Gaps = 11/237 (4%)
Query: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
W G CS CG G + I C T +S C + +P P+ CN+ PC +
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCVH--RSTHEEAPESYCDSSMKPTPEEEPCNIFPCPA 678
Query: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEGQDCL 922
W G WS CS TC G QHR+V C Q+ + +P C +P +C+ + C
Sbjct: 679 FWDIGEWSECSKTCGLGMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
Query: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQG------KCDASTRPRAEEACEDYSGCYEW 976
++W+ CS CG G R V C ++ G +C+ RP E C+ W
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSW 797
Query: 977 KTGDWS-TCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
+WS CS+ CG G+++R V CM E ++PA C C ++
Sbjct: 798 FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKV 854
Score = 87.8 bits (216), Expect = 5e-17
Identities = 58/173 (33%), Positives = 79/173 (45%), Gaps = 16/173 (9%)
Query: 804 WTHSGW-EGCSVQCGGGER-RTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC 861
W + W E CS +CG G R R++V T V+ ++ P + P C+ PC
Sbjct: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATP------CDNGPC 850
Query: 862 QSR--WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEG 918
+ W AG WS CS C G Q REV CV + + T P C +P + QSC
Sbjct: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKPPSQQSCHL 909
Query: 919 QDCLSIWEASEWSQCSASCGKGVWKRTVACTNS----QGKCDASTRPRAEEAC 967
+ C + W ++EWS CS SC G R V C + CD +P E+C
Sbjct: 910 KPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC 962
Score = 83.2 bits (204), Expect = 1e-15
Identities = 44/138 (31%), Positives = 66/138 (47%), Gaps = 6/138 (4%)
Query: 785 NRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCP 844
NR AE P W W CS++CG G ++ V C R T +++ S+C
Sbjct: 837 NRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECS 896
Query: 845 QASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLY 904
+P P + C+L PC ++W + WS CS +C+ GF+ REV C+ + L
Sbjct: 897 FLEKP-PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCL-----SDDMTLSNLC 950
Query: 905 CPGPRPAAVQSCEGQDCL 922
P +P +SC QDC+
Sbjct: 951 DPQLKPEERESCNPQDCV 968
Score = 42.0 bits (97), Expect = 0.003
Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 6/58 (10%)
Query: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE--CPALSKPAPYRQCYQEVCN 1029
+ WK + CS+TCGKG Q + +C+H+ T E C + KP P +E CN
Sbjct: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTP----EEEPCN 672
Score = 37.0 bits (84), Expect = 0.10
Identities = 13/27 (48%), Positives = 15/27 (55%)
Query: 544 GDWSPWGAWSMCSRTCGTGARFRQRKC 570
G W WG WS CSR+C G + R C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 32.0 bits (71), Expect = 3.3
Identities = 12/21 (57%), Positives = 14/21 (66%)
Query: 550 GAWSMCSRTCGTGARFRQRKC 570
G WS CS+TCG G + RQ C
Sbjct: 683 GEWSECSKTCGLGMQHRQVLC 703
Score = 32.0 bits (71), Expect = 3.3
Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 31/118 (26%)
Query: 473 NEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGEC 532
+E+C + N N + CA W L E C ECGA R+ C
Sbjct: 773 DEECNMKLRPNDI--ENCDMGPCAKSWFLTEWSERCSA---------ECGAGVRTRSVVC 821
Query: 533 ----VSKTPIP--------EHVDGDWSP------W--GAWSMCSRTCGTGARFRQRKC 570
VS P+ E D P W G+WS CS CG+G + R+ C
Sbjct: 822 MTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVIC 879
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,606,197
Number of Sequences: 37866
Number of extensions: 2955880
Number of successful extensions: 11338
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 9100
Number of HSP's gapped (non-prelim): 1087
length of query: 1095
length of database: 18,247,518
effective HSP length: 113
effective length of query: 982
effective length of database: 13,968,660
effective search space: 13717224120
effective search space used: 13717224120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.