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Search of human proteins with 110611167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
(1226 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 2620 0.0
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 2608 0.0
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 1382 0.0
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 1283 0.0
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 639 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 517 e-146
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 508 e-143
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 496 e-140
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 476 e-134
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 469 e-132
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 438 e-122
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 437 e-122
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 435 e-121
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 431 e-120
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 419 e-116
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 397 e-110
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 377 e-104
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 364 e-100
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 362 1e-99
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 330 5e-90
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 330 5e-90
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 325 2e-88
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 313 5e-85
gi|145309328 papilin [Homo sapiens] 215 2e-55
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 213 1e-54
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 213 1e-54
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 208 3e-53
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 169 1e-41
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 169 1e-41
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 166 1e-40
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 2620 bits (6791), Expect = 0.0
Identities = 1226/1226 (100%), Positives = 1226/1226 (100%)
Query: 1 MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP 60
MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP
Sbjct: 1 MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP 60
Query: 61 AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR 120
AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR
Sbjct: 61 AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR 120
Query: 121 LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT 180
LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT
Sbjct: 121 LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT 180
Query: 181 DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV 240
DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV
Sbjct: 181 DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV 240
Query: 241 GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL 300
GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL
Sbjct: 241 GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL 300
Query: 301 GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT 360
GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT
Sbjct: 301 GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT 360
Query: 361 RQDFGPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD 420
RQDFGPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD
Sbjct: 361 RQDFGPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD 420
Query: 421 ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS 480
ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS
Sbjct: 421 ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS 480
Query: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK 540
MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK
Sbjct: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK 540
Query: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE 600
GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE
Sbjct: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE 600
Query: 601 YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD 660
YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD
Sbjct: 601 YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD 660
Query: 661 VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK 720
VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK
Sbjct: 661 VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK 720
Query: 721 GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT 780
GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT
Sbjct: 721 GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT 780
Query: 781 FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG 840
FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG
Sbjct: 781 FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG 840
Query: 841 SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI 900
SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI
Sbjct: 841 SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI 900
Query: 901 RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP 960
RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP
Sbjct: 901 RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP 960
Query: 961 EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS 1020
EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS
Sbjct: 961 EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS 1020
Query: 1021 LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD 1080
LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD
Sbjct: 1021 LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD 1080
Query: 1081 RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP 1140
RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP
Sbjct: 1081 RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP 1140
Query: 1141 TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP 1200
TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP
Sbjct: 1141 TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP 1200
Query: 1201 VPEDKGQPGEDLRHPGTSLPAASPVT 1226
VPEDKGQPGEDLRHPGTSLPAASPVT
Sbjct: 1201 VPEDKGQPGEDLRHPGTSLPAASPVT 1226
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 2608 bits (6761), Expect = 0.0
Identities = 1223/1226 (99%), Positives = 1223/1226 (99%), Gaps = 3/1226 (0%)
Query: 1 MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP 60
MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP
Sbjct: 1 MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP 60
Query: 61 AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR 120
AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR
Sbjct: 61 AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR 120
Query: 121 LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT 180
LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT
Sbjct: 121 LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT 180
Query: 181 DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV 240
DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV
Sbjct: 181 DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV 240
Query: 241 GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL 300
GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL
Sbjct: 241 GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL 300
Query: 301 GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT 360
GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT
Sbjct: 301 GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT 360
Query: 361 RQDFGPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD 420
RQDFGPSG YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD
Sbjct: 361 RQDFGPSG---YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD 417
Query: 421 ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS 480
ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS
Sbjct: 418 ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS 477
Query: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK 540
MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK
Sbjct: 478 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK 537
Query: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE 600
GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE
Sbjct: 538 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE 597
Query: 601 YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD 660
YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD
Sbjct: 598 YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD 657
Query: 661 VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK 720
VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK
Sbjct: 658 VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK 717
Query: 721 GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT 780
GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT
Sbjct: 718 GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT 777
Query: 781 FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG 840
FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG
Sbjct: 778 FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG 837
Query: 841 SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI 900
SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI
Sbjct: 838 SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI 897
Query: 901 RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP 960
RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP
Sbjct: 898 RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP 957
Query: 961 EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS 1020
EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS
Sbjct: 958 EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS 1017
Query: 1021 LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD 1080
LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD
Sbjct: 1018 LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD 1077
Query: 1081 RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP 1140
RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP
Sbjct: 1078 RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP 1137
Query: 1141 TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP 1200
TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP
Sbjct: 1138 TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP 1197
Query: 1201 VPEDKGQPGEDLRHPGTSLPAASPVT 1226
VPEDKGQPGEDLRHPGTSLPAASPVT
Sbjct: 1198 VPEDKGQPGEDLRHPGTSLPAASPVT 1223
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 1382 bits (3577), Expect = 0.0
Identities = 653/1166 (56%), Positives = 796/1166 (68%), Gaps = 101/1166 (8%)
Query: 37 DYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTL 96
+Y + P ST+ GR+LSH +S + V P
Sbjct: 41 EYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP----------------------- 77
Query: 97 WPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQED----------------- 139
L+FN+T FGK+ HLRL+PN +LV PG+ VEW E
Sbjct: 78 -------EQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPG 130
Query: 140 ---FRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQE 196
+R +PL+ C Y G + +PG +VAISNCDGLAG+I++D+ ++FIEPLERG+Q
Sbjct: 131 SATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQM 190
Query: 197 KEASGRTHVVYRREAVQQEWAEPDGDLH---NEAFGLGDLPNLLGLVGDQLGDTERKRRH 253
+E GR HVVY+R AV+Q + D H ++ GL DL + G + QL +T R+RRH
Sbjct: 191 EEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRH 250
Query: 254 AKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIM 313
A Y+IEVLL VDDSVVRFHGKEHVQNY+LTLMNIV+EIYHDESLGVHIN+ LVR+IM
Sbjct: 251 AGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIM 310
Query: 314 VGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGMQGYA 373
+GY +S+SLIERGNPSRSLE VCRWA QQR D +H+EHHDH +FLTRQDFGP+GMQGYA
Sbjct: 311 LGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYA 370
Query: 374 PVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQ 433
PVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DET++GSVMAPLVQ
Sbjct: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQ 430
Query: 434 AAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGY 493
AAFHR+HWSRCS EL RY+ SYDCLLDDPFD WP+ PELPGINYSMDEQCRFDFG GY
Sbjct: 431 AAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGY 490
Query: 494 QTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG 553
+ C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGTECA GKWC+KGHC+WK+ Q
Sbjct: 491 KMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQ-QK 549
Query: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
QDG W SWTKFGSCSR+CG GVR R+R CNNP P GG+ C G FEYQ+CN+EEC +
Sbjct: 550 QDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609
Query: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
EDFRAQQC +RNS++ +QN KH W+PYE D ++C L CQS +TGDV +M Q+VHDGT
Sbjct: 610 EDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTH 669
Query: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
CSY+DPYS+C RGECV VGCDKE+GS K +DKCGVCGGDNSHCRTVKGT + ++ G L
Sbjct: 670 CSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYL 729
Query: 734 KLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVE 793
K+ IP GARH+ I+ E SPH + +KNQ TG +ILN KG+EA SRTF +G+EW+ +E
Sbjct: 730 KMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIE 789
Query: 794 DAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYE 853
D ESL T GPL + + +L + P E RSSL YKY+IHED +P I SNNV+ EE+DT+E
Sbjct: 790 DDIESLHTDGPLHDPVIVLII-PQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFE 848
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
WALKSW+ CSK CGGG Q+TKYGCRR+ D+ MV R C+ K+PKPIRR CN C+ P+
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
WV EEW C+++CG G Q R ++CL PL +GT++ + +K C GDRPE+RRPC RVPCPA
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPA 968
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1033
QW+ G WS+CS TCGEG + RQV+CR HC+G++P++V+ C LP C
Sbjct: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAG----DHCDGEKPESVRACQLPPC--------- 1015
Query: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1093
+ EPC GD+S+FCQMEVL RYCSIPGY++LCC
Sbjct: 1016 ----------------------------NDEPCLGDKSIFCQMEVLARYCSIPGYNKLCC 1047
Query: 1094 VSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQ 1153
SC K++S P P L T + P D + P +
Sbjct: 1048 ESCSKRSS-----TLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMS 1102
Query: 1154 LPGALDTSSPGTQHPFAPETPIPGAS 1179
L P F P + GA+
Sbjct: 1103 LSSISSVGGPNAYAAFRPNSKPDGAN 1128
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 1283 bits (3319), Expect = 0.0
Identities = 635/1182 (53%), Positives = 793/1182 (67%), Gaps = 47/1182 (3%)
Query: 13 PLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDT 72
P + L AAA L G ++ + VP TD +GR +SHVVS A + AG
Sbjct: 34 PANARLAAAADPPGGPL---GHGAERILAVPVRTDAQGRLVSHVVSA-ATSRAGVRARRA 89
Query: 73 PPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGS 132
P R+P PGG G H L++NVTVFG++LHLRLRPN RLV PG+
Sbjct: 90 APV-----------RTPSFPGGN--EEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGA 135
Query: 133 SVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE 191
++EWQ + +PL C+Y G V G+ A+ VA+SNCDGLAGLIR + +FFIEPLE
Sbjct: 136 TMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLE 195
Query: 192 RGQQEKEAS-GRTHVVYRREAVQQEWAEPDG-DLHNEAFGLGDLPNLLGLVGDQLGDTER 249
+G +EA GR HVVYRR P D L L LG++ + + R
Sbjct: 196 KGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
Query: 250 K-RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
+ RRHA Y+IEVLL VDDSVV+FHGKEHVQ Y+LTLMNIV+EIYHDESLG HIN+ L
Sbjct: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
Query: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG 368
VR+I++ Y +S+SLIE GNPS+SLE VCRWA+ QQ+ D H E+HDH +FLTRQDFGPSG
Sbjct: 316 VRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
Query: 369 MQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 428
MQGYAPVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DE LGS+M
Sbjct: 376 MQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIM 435
Query: 429 APLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFD 488
APLVQAAFHRFHWSRCS+ ELSRYL SYDCLLDDPF WP P+LPG++YSM+EQCRFD
Sbjct: 436 APLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFD 495
Query: 489 FGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSP 548
FG GY C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGT CAPGK CFKGHCIW +P
Sbjct: 496 FGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTP 555
Query: 549 EQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEE 608
+ +DG W +W+ FGSCSR+CG GV+ R+R C+NP PA GGR C G +++Q+C+ ++
Sbjct: 556 D-ILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQD 614
Query: 609 CPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVV 668
CP + DFR +QC + + Y+ H +A+H W+P+E D ++C L C+S +TG+VV M ++V
Sbjct: 615 CPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
Query: 669 HDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASK 728
HDGTRCSY+D +S+C RG+C VGCD +GS K +DKCGVCGGDNSHC+ VKGT ++ K
Sbjct: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPK 734
Query: 729 QAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGK-EATSRTFTAMGLE 787
+ G +K+ +IPAGARH+ I+ ++ + H + VKN TG FILN + +A+S+TF AMG+E
Sbjct: 735 KHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVE 794
Query: 788 WEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLE 847
WE ED +E+L+T GPL I +L +P G R SL YKY+IHED L + NNVL E
Sbjct: 795 WEYRDEDGRETLQTMGPLHGTITVLVIP--VGDTRVSLTYKYMIHEDSLN-VDDNNVLEE 851
Query: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
+ YEWALK W+PCSK CGGG QFTKYGCRRR DH MV R C +PK IRR CN
Sbjct: 852 DSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQ 911
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
CSQPVWVT EW CS++CG+ G+Q R ++C+ PL + T + + AK C RPE+RR C
Sbjct: 912 ECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACS 971
Query: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGN 1027
R CP +WR G WSQCS TCG G Q+R V+CRT +S G C+ +RP+T + C L C N
Sbjct: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRN 1031
Query: 1028 HQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPG 1087
+ + ++ V QW+ + +P PI KISS C GD+S+FC+MEVL RYCSIPG
Sbjct: 1032 ISDPSKKSYV-------VQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPG 1084
Query: 1088 YHRLCCVSC--------IKKASGPNPGP----DPGPTSLPPFSTPGSPLPGPQDPADAAE 1135
Y++LCC SC ++ P PG D +LP + P P P +
Sbjct: 1085 YNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPL 1144
Query: 1136 PPGKPTGSEDHQHGRATQLPGALDTSSPGTQHP-FAPETPIP 1176
+EDH A P + Q P P P P
Sbjct: 1145 NASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSP 1186
Score = 31.2 bits (69), Expect = 6.3
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 1114 LPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPET 1173
LPP P P P A AA+PPG P G H R +P D H + T
Sbjct: 23 LPPPLLPPPPPPANARLAAAADPPGGPLG---HGAERILAVPVRTDAQGRLVSHVVSAAT 79
Query: 1174 PIPG-----ASWSISPTTPGG 1189
G A+ +P+ PGG
Sbjct: 80 SRAGVRARRAAPVRTPSFPGG 100
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 639 bits (1649), Expect = 0.0
Identities = 330/550 (60%), Positives = 385/550 (70%), Gaps = 23/550 (4%)
Query: 13 PLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDT 72
P + L AAA L G ++ + VP TD +GR +SHVVS A + AG
Sbjct: 34 PANARLAAAADPPGGPL---GHGAERILAVPVRTDAQGRLVSHVVSA-ATSRAGVRARRA 89
Query: 73 PPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGS 132
P R+P PGG G H L++NVTVFG++LHLRLRPN RLV PG+
Sbjct: 90 APV-----------RTPSFPGGN--EEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGA 135
Query: 133 SVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE 191
++EWQ + +PL C+Y G V G+ A+ VA+SNCDGLAGLIR + +FFIEPLE
Sbjct: 136 TMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLE 195
Query: 192 RGQQEKEAS-GRTHVVYRREAVQQEWAEPDG-DLHNEAFGLGDLPNLLGLVGDQLGDTER 249
+G +EA GR HVVYRR P D L L LG++ + + R
Sbjct: 196 KGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
Query: 250 K-RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
+ RRHA Y+IEVLL VDDSVV+FHGKEHVQ Y+LTLMNIV+EIYHDESLG HIN+ L
Sbjct: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
Query: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG 368
VR+I++ Y +S+SLIE GNPS+SLE VCRWA+ QQ+ D H E+HDH +FLTRQDFGPSG
Sbjct: 316 VRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
Query: 369 MQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 428
MQGYAPVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DE LGS+M
Sbjct: 376 MQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIM 435
Query: 429 APLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFD 488
APLVQAAFHRFHWSRCS+ ELSRYL SYDCLLDDPF WP P+LPG++YSM+EQCRFD
Sbjct: 436 APLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFD 495
Query: 489 FGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSP 548
FG GY C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGT CAPGK+ G
Sbjct: 496 FGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKF-RPGAVAHACY 554
Query: 549 EQTYGQDGGW 558
T G G W
Sbjct: 555 PSTLGGQGRW 564
Score = 31.2 bits (69), Expect = 6.3
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 1114 LPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPET 1173
LPP P P P A AA+PPG P G H R +P D H + T
Sbjct: 23 LPPPLLPPPPPPANARLAAAADPPGGPLG---HGAERILAVPVRTDAQGRLVSHVVSAAT 79
Query: 1174 PIPG-----ASWSISPTTPGG 1189
G A+ +P+ PGG
Sbjct: 80 SRAGVRARRAAPVRTPSFPGG 100
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 517 bits (1332), Expect = e-146
Identities = 348/1134 (30%), Positives = 525/1134 (46%), Gaps = 130/1134 (11%)
Query: 35 LSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGG 94
L Y +T+P D G FLS V +HS R + P+ P
Sbjct: 39 LEHYQLTIPIRVDQNGAFLSFTVKND-----------------KHSRRRR-SMDPIDPQQ 80
Query: 95 TLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVY 154
+ L+F ++ +GK HL L N V +VE+ ++ C Y
Sbjct: 81 AV-------SKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHY 133
Query: 155 TGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLERGQQEKE----ASGRTHVVYRR 209
TG + VA+SNC GL G+I T+ ++FIEPL+ ++ + +G HV+Y++
Sbjct: 134 TGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKK 193
Query: 210 EAVQQEWAEPDGDLHNEAFGLGDLP---NLLGLVGDQLGDTERKRRHAKPGSYSIE---- 262
A+QQ F P N V L H + S SIE
Sbjct: 194 SALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVE 253
Query: 263 VLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSL 322
L+V D +V +HG++ +++Y+L++MNIV ++Y D SLG +NI + RLI++ Q +L
Sbjct: 254 TLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP-NL 312
Query: 323 IERGNPSRSLEQVCRWAHS---QQRQDPSHAE----HHDHVVFLTRQDF-----GPSGMQ 370
+ +SL+ C+W S Q + E HHD+ V +TR D P G
Sbjct: 313 EINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTL 372
Query: 371 GYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADET-SLGSVMA 429
G A V GMC P RSC++N + G SAF IAHE GH GM HDG GN C + +MA
Sbjct: 373 GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMA 432
Query: 430 PLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRF 487
+ A + F WS CS+ ++ +L S CL ++P + P PG Y DEQCRF
Sbjct: 433 AHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRF 492
Query: 488 DFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGK----WCFKGHC 543
+G+ + C + E C++LWC N C T P +GT C G WC++G C
Sbjct: 493 QYGATSRQC---KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDC 547
Query: 544 IWKSPEQTYGQ--DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEY 601
+ P T+ Q DGGW W+ +G CSR+CGGGV S R C++P+P+ GG+ CLG Y
Sbjct: 548 V---PFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRY 604
Query: 602 QVCNSEECPGTYEDFRAQQCAK------RNSYYVHQNAKHSWVPYEPDDDAQKCELICQS 655
+ CN++ CP DFR +QCA R YY +W PY + C L C +
Sbjct: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYY-------NWKPY-TGGGVKPCALNCLA 656
Query: 656 ADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSH 715
V DGT+C+ D +C GEC VGCD +GS +D+C VCGGD S
Sbjct: 657 EGYNFYTERAPAVIDGTQCN-ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGST 715
Query: 716 CRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKE 775
C ++G + + G +++VQIP G+ HI++ + S + I +K++ + +N
Sbjct: 716 CDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSE-GDDYYINGAWTI 774
Query: 776 ATSRTFTAMGLEWE-DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHED 834
R F G + D ESL+ GP E + ++ L + +L +Y +
Sbjct: 775 DWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQ-----NLGIRYKFNVP 829
Query: 835 LLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHK 894
+ +N + + W + W+ CS C GG+Q + C+R D+ +VQ + CD
Sbjct: 830 ITRTGSGDNEV-----GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPD 884
Query: 895 KRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKA 954
+P +R CN PC P W +W CS++C G++TR + C+ + + +
Sbjct: 885 SKPPENQRACNTEPC-PPEWFIGDWLECSKTCDG-GMRTRAVLCIRKIGPSEEETLDYSG 942
Query: 955 CAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANS----LGHCEG 1010
C RP + PC CP QW WS+C+ CG G + R V+C+++ S C
Sbjct: 943 CLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPE 1002
Query: 1011 DRPDTVQV-CSL-----------------PACGGNHQNSTVR---------ADVWELGTP 1043
+ V++ CSL CG Q TV+ +D E P
Sbjct: 1003 ESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
Query: 1044 EGQWVPQSEPLHPINKISSTEPCTG-DRSVFCQMEVLDRYCSIPGYHRLCCVSC 1096
+ Q E IS+TE C ++ +C + + ++CS + ++CC +C
Sbjct: 1063 PS--MQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 508 bits (1308), Expect = e-143
Identities = 388/1267 (30%), Positives = 568/1267 (44%), Gaps = 163/1267 (12%)
Query: 73 PPTLPRHSSHLRVARSPLHP-----GGT-----LWPGRVGRHSL--------YFNVTVFG 114
P P ++ R A +HP GG+ LWP + + + ++ + G
Sbjct: 29 PGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRG 88
Query: 115 KELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQE---CVYTGGVTG--MPGAAVAIS 169
+EL L N+ L+ PG E + L R +R C G V + G AIS
Sbjct: 89 RELRFNLTANQHLLAPGFVSETRRR-GGLGRAHIRAHTPACHLLGEVQDPELEGGLAAIS 147
Query: 170 NCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFG 229
CDGL G+ + + D+FIEPL+ + + HVVY+R+A ++ D + G
Sbjct: 148 ACDGLKGVFQLSNEDYFIEPLDSAPA-RPGHAQPHVVYKRQAPERLAQRGDSSAPSTC-G 205
Query: 230 LGDLPNLLGL-----VGDQLGDTERKRRHAKPGSYS--IEVLLVVDDSVVRFHGKEHVQN 282
+ P L Q +R H + S +E L+V D +V +HG+ V++
Sbjct: 206 VQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVES 265
Query: 283 YVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQ 342
YVLT+MN+V ++HD S+G I+I +VRL+++ + I + +L+ C+W S
Sbjct: 266 YVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITH-HADNTLKSFCKWQKSI 324
Query: 343 QRQDPSHAEHHDHVVFLTRQDF-----GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAF 397
+ +H HHD + LTR+D P G + V GMC P RSC++N + G AF
Sbjct: 325 NMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAF 384
Query: 398 VIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLP-SY 456
+AHE GH G++HDG GN C +M+P + WSRCS+ ++R+L +
Sbjct: 385 TVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGW 444
Query: 457 DCLLDDPFDPA-----WPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCS 511
LDDP PA +P P PG+ Y + QCR +G+ C C LWCS
Sbjct: 445 GLCLDDP--PAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMDNV--CHTLWCS 498
Query: 512 HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKS--PEQTYGQDGGWSSWTKFGSCSR 569
C +K +DGT C KWC G C+ PE DGGWS W+ + CSR
Sbjct: 499 VGTT---CHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV---DGGWSGWSAWSICSR 552
Query: 570 SCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYV 629
SCG GV+S R C P+P Y GR C+G +++CN + CP FR QC+ ++ +
Sbjct: 553 SCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDA-ML 611
Query: 630 HQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRC-SYRDPYSVCARGEC 688
++ H+WVP +D CEL C+ A+ + V DGT C R +C G C
Sbjct: 612 YKGQLHTWVPVV--NDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGIC 669
Query: 689 VPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIE 748
VGCD E+ S +D+CGVC G+ S C TV GT +A + G + + IPAGAR I+I+
Sbjct: 670 KNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRIQ 728
Query: 749 ALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEA 808
+ ++ + + ++++ + LN + + G + A E+L + GP E
Sbjct: 729 EVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKEP 788
Query: 809 IAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGG 868
+ I L E P + Y+Y IH + G ++ + + W W C+ CG
Sbjct: 789 VWIQLL-FQESNP--GVHYEYTIHRE----AGGHDEV--PPPVFSWHYGPWTKCTVTCGR 839
Query: 869 GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGK 928
G+Q C R+ + + H CD RP +R+C++ PC W EW CS SCG
Sbjct: 840 GVQRQNVYCLERQAGPVDEEH-CDPLGRPDDQQRKCSEQPCPAR-WWAGEWQLCSSSCGP 897
Query: 929 LGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLR-VPCPAQWRLGAWSQCSAT 986
G+ R + C+ + + AC RP PC R VPCPA W +G WSQCS T
Sbjct: 898 GGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVT 957
Query: 987 CGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGT--PE 1044
CGEG Q+R V+C TN + E +P + CSLP C W LGT PE
Sbjct: 958 CGEGTQRRNVLC-TNDTGVPCDEAQQPASEVTCSLPLCR------------WPLGTLGPE 1004
Query: 1045 G--------------QWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPG--- 1087
G ++P P + SS +P T ++ + LD +PG
Sbjct: 1005 GSGSGSSSHELFNEADFIPHHLAPRP-SPASSPKPGTMGNAIEEEAPELD----LPGPVF 1059
Query: 1088 ----YHRLCCVSCIKKAS-GPNPGPD----------PGPTSLPPFSTPGSPLPGPQDPAD 1132
Y+ ++ + S GP+ PD P P S P + GSP+P + PA
Sbjct: 1060 VDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPAA 1119
Query: 1133 AAE-------PPGKPTGSEDHQHGRATQLPG-ALDTSSPGTQHPF-APETPIPGASWS-- 1181
E P P+ + + Q PG L P P AP+ +P SW
Sbjct: 1120 KEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPLINFLPEEDTPIGAPDLGLPSLSWPRV 1179
Query: 1182 -----ISPTTP-------------GGLPWGWTQTPTPVPEDKGQP-GEDLRH----PGTS 1218
+P TP LP W V +D +P G H P ++
Sbjct: 1180 STDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHLPPRPSST 1239
Query: 1219 LPAASPV 1225
LP SPV
Sbjct: 1240 LPPLSPV 1246
Score = 104 bits (259), Expect = 6e-22
Identities = 89/282 (31%), Positives = 108/282 (38%), Gaps = 55/282 (19%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
W +W+ CS CG G + C RD C RP+P RRC+ PC+
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRPQP-ARRCHLRPCA--T 1465
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQC-----LLPLSNGTHKVMPAKACAGDRPEARRPCLR 968
W + W CSRSCG G R +QC L PL + PAK P A RPC
Sbjct: 1466 WHSGNWSKCSRSCGG-GSSVRDVQCVDTRDLRPLRPFHCQPGPAK------PPAHRPCGA 1518
Query: 969 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC-EGDRPDTVQVCSL------ 1021
PC W +W +CS CG G QQR V C G C E RP+T + C+
Sbjct: 1519 QPC-LSWYTSSWRECSEACGGGEQQRLVTC----PEPGLCEEALRPNTTRPCNTHPCTQW 1573
Query: 1022 ---------PACGGNHQNSTVRADVWELGTPEGQ--------WVPQSEPLHPINKISSTE 1064
CGG Q V+ + G PE W S P E
Sbjct: 1574 VVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC-GTEDCEPVE 1632
Query: 1065 P--CTGDRSV--FCQMEVLDRYCSIPGYHRLCCVSCIKKASG 1102
P C DR FC+ L C +P CC SC + G
Sbjct: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHG 1674
Score = 40.4 bits (93), Expect = 0.010
Identities = 27/87 (31%), Positives = 36/87 (41%), Gaps = 2/87 (2%)
Query: 946 THKVMPAKACAGDRPEARRPC-LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANS 1004
+H+V + A EA P V A W+ G WS+CS TCG G R V C + +
Sbjct: 1385 SHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE 1444
Query: 1005 LGHCEGDRPDTVQVCSLPACGGNHQNS 1031
RP + C L C H +
Sbjct: 1445 -DCAPAGRPQPARRCHLRPCATWHSGN 1470
Score = 30.8 bits (68), Expect = 8.3
Identities = 27/104 (25%), Positives = 38/104 (36%), Gaps = 11/104 (10%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGC-RRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
+W + W CS CGGG+Q C + C H+ P+ R C C +
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES-SRPCGTEDC-E 1629
Query: 912 PVWVTE------EWGACS--RSCGKLGVQTRGIQCLLPLSNGTH 947
PV +G C R G+ + T QC S +H
Sbjct: 1630 PVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSH 1673
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 496 bits (1277), Expect = e-140
Identities = 343/1102 (31%), Positives = 497/1102 (45%), Gaps = 125/1102 (11%)
Query: 14 LHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTP 73
L CA AAA + SG DY P D G ++SH +
Sbjct: 37 LCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDI---------------- 80
Query: 74 PTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSS 133
LH G + R SL++ + FG+ELHL L+P+ L
Sbjct: 81 ----------------LHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSSHFIV 124
Query: 134 VEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPL--- 190
+D ++P Q+C Y G + ++VA+S C GL+GLIRT +F I PL
Sbjct: 125 QVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQL 184
Query: 191 --ERGQQEKEASGRTHVVYRR---EAVQQEWAEPDGDLHNEAFGLGDLPNLLG------- 238
+ A HV+Y+R E +Q+ P + + +P+
Sbjct: 185 LAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYH 244
Query: 239 --------------------------LVGDQLGDTERKRRHAKPGS--YSIEVLLVVDDS 270
L D+ G + R RR A ++E L+V D
Sbjct: 245 HRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKK 304
Query: 271 VVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSR 330
+V HGK +V Y+LT+MN+V ++ D ++G IN+ +V LI++ LI + +
Sbjct: 305 MVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINH-HADQ 363
Query: 331 SLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-----GPSGMQGYAPVTGMCHPLRSC 385
SL C+W Q + + HDH + LT D P G+AP++GMC RSC
Sbjct: 364 SLNSFCQW---QSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC 420
Query: 386 ALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCS 445
+N + G AF IAHE+GH GM HDG+GN C + G++M+P + F WS CS
Sbjct: 421 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPC--RKAEGNIMSPTLTGNNGVFSWSSCS 478
Query: 446 KLELSRYL--PSYDCLLDDPFDPA-WPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTF 502
+ L ++L P CL+D+P + P +LPG Y D QC++ FG+ + C
Sbjct: 479 RQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVK 538
Query: 503 EPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW---KSPEQTYGQDGGWS 559
+ CK LWC + C+TK P +GT C WC +G C+ P +GQ WS
Sbjct: 539 DICKSLWCHRVGHR--CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQ---WS 593
Query: 560 SWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQ 619
+W+K+ CSR+CGGGV+ + R CNNP P YGG C G YQ+CN C DFRAQ
Sbjct: 594 AWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQ 653
Query: 620 QCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDP 679
QCA+ NS + + W PY ++ +C+L C++ + M+ V DGT CS +
Sbjct: 654 QCAEYNS-KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCS-PNK 711
Query: 680 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIP 739
VC G C VGCD E+GS D CGVC GDNS C+ KG K +V IP
Sbjct: 712 NDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIP 771
Query: 740 AGARHIQIEALEKSPHRIVV-----KNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVED 794
AGAR I+I+ L+ S + V K +TG + ++ G+ F E++ + +
Sbjct: 772 AGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGE----FPFAGTTFEYQRSF-N 826
Query: 795 AKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEW 854
E L GP E + L G +A+KY LP + + + Y W
Sbjct: 827 RPERLYAPGPTNETLVFEILMQ---GKNPGIAWKYA-----LPKVMNGTPPATKRPAYTW 878
Query: 855 ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 914
++ + CS +CGGG K C R + + V C K +P + CN C W
Sbjct: 879 SIVQ-SECSVSCGGGYINVKAICLRDQ-NTQVNSSFCSAKTKPVTEPKICNAFSC-PAYW 935
Query: 915 VTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQ 974
+ EW CS++C G Q+R IQC+ + + C P + C CP Q
Sbjct: 936 MPGEWSTCSKACAG-GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQ 994
Query: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEG-DRPDTVQVCSLPACGGNHQN 1030
W LG WSQCS TCG G+++R+++C+ +A C RP+ + C L C N +
Sbjct: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
Query: 1031 STVRADVWELGTPEGQWVPQSE 1052
V + E G V + E
Sbjct: 1055 QWVASSWSECSATCGLGVRKRE 1076
Score = 81.3 bits (199), Expect = 5e-15
Identities = 66/265 (24%), Positives = 101/265 (38%), Gaps = 56/265 (21%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC--- 909
+W+L W+ CSK CG G++ + C+ + + C RP+ ++ C C
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQ-CTSLPRPE-LQEGCVLGRCPKN 1051
Query: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP---EARRPC 966
S+ WV W CS +CG LGV+ R ++C G P + C + + C
Sbjct: 1052 SRLQWVASSWSECSATCG-LGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
Query: 967 LRVPCPAQ--------WRLGAWSQCSATCGEGIQQRQVVC----RTNANSLGHCEGDRPD 1014
R CPA W W QC+ TCG G+Q R V C R +++ L H +P
Sbjct: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLH---QKPP 1167
Query: 1015 TVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFC 1074
++ C+ C PE +P D +C
Sbjct: 1168 VLRACNTNFC----------------PAPE----------------KREDPSCVDFFNWC 1195
Query: 1075 QMEVLDRYCSIPGYHRLCCVSCIKK 1099
+ C+ Y + CC SC +K
Sbjct: 1196 HLVPQHGVCNHKFYGKQCCKSCTRK 1220
Score = 33.9 bits (76), Expect = 0.98
Identities = 25/92 (27%), Positives = 34/92 (36%), Gaps = 9/92 (9%)
Query: 519 CKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSR 578
C+ K P LD E + C Y GW S + C+ +CGGGV++R
Sbjct: 1096 CRNIKKPNLDLEETCNRRAC--------PAHPVYNMVAGWYS-LPWQQCTVTCGGGVQTR 1146
Query: 579 SRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
S C L + CN+ CP
Sbjct: 1147 SVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 476 bits (1224), Expect = e-134
Identities = 345/1096 (31%), Positives = 486/1096 (44%), Gaps = 112/1096 (10%)
Query: 74 PTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSS 133
PT H+ L P G L++ V L L + RL+ S
Sbjct: 44 PTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVS 103
Query: 134 VEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE- 191
VE+ +++ R C+Y G + G + VAIS C GL GLI D ++ IEPL
Sbjct: 104 VEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHG 163
Query: 192 --RGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGD---LPNLLGLVGDQLGD 246
+G + E SG HVVY+R +++ + + +E G L L LG+
Sbjct: 164 GPKGSRSPEESG-PHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGN 222
Query: 247 TERKRRHAKPGSYS----IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGV 302
+ + S S +E L+V D +V +HG+ V+ YVL +MNIV +++ D SLG
Sbjct: 223 ETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGS 282
Query: 303 HINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEH---------- 352
+NI + RLI++ Q I + +SL+ C+W Q+ +H+ H
Sbjct: 283 TVNILVTRLILLTEDQPTLEITH-HAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVA 337
Query: 353 -HDHVVFLTRQDF-----GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHV 406
HD V +TR D P G G APV GMC RSC++N + G ++AF IAHE GH
Sbjct: 338 NHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHT 397
Query: 407 LGMEHDGQGNGC-ADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDP 463
GM HDG GN C A +MA + + F WS CS+ ++ +L S CL + P
Sbjct: 398 FGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
Query: 464 FDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKK 523
+ P PG Y DEQCRF G + C + E C +LWC N C T
Sbjct: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNS 512
Query: 524 GPPLDGTECAPGK----WCFKGHCI--WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577
P +GT C WC+K C+ PE G DG W WT +G CSR+CGGGV S
Sbjct: 513 IPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE---GVDGAWGPWTPWGDCSRTCGGGVSS 569
Query: 578 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSW 637
SR C++P P GG+ CLG ++ CN+++CP +DFR QC++ +S + + W
Sbjct: 570 SSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSI-PFRGKFYKW 628
Query: 638 VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEV 697
Y + C L C + V DGT C D +C GEC VGCD+ +
Sbjct: 629 KTYR-GGGVKACSLTCLAEGFNFYTERAAAVVDGTPCR-PDTVDICVSGECKHVGCDRVL 686
Query: 698 GSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRI 757
GS +DKC VCGGD S C T++G AS AG +V IP G+ HI I+ L S +
Sbjct: 687 GSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHL 746
Query: 758 VVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPT 817
+K + G R A D +SL+ GP+ ++ ++ L T
Sbjct: 747 ALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLART 806
Query: 818 EGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGC 877
E P + I D LP Y W W CS C GG Q C
Sbjct: 807 EL-PALRYRFNAPIARDSLP-------------PYSWHYAPWTKCSAQCAGGSQVQAVEC 852
Query: 878 RRRRDHHMVQRHLCD-HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGI 936
R + D V H C H K PK +R CN PC P WV W CSRSC GV++R +
Sbjct: 853 RNQLDSSAVAPHYCSAHSKLPKR-QRACNTEPCP-PDWVVGNWSLCSRSCDA-GVRSRSV 909
Query: 937 QCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQV 996
C +S K + AC RP C CP +W WS+C+ +CG G++ R V
Sbjct: 910 VCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVV 969
Query: 997 VCRTNANSL----GHCE-GDRPDTVQVCSL----PA-------------CGGNHQNSTVR 1034
+C++ + HC +P C+L PA CG + +VR
Sbjct: 970 LCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVR 1029
Query: 1035 ADVWELGTPEGQWVPQ-SEPLHPIN------KISSTEPCTG-------DRSVFCQMEVLD 1080
+ GQ + +E L P K S P G ++ +C + +
Sbjct: 1030 CT-----SHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKF 1084
Query: 1081 RYCSIPGYHRLCCVSC 1096
++CS + ++CC +C
Sbjct: 1085 QFCSRAYFRQMCCKTC 1100
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 469 bits (1207), Expect = e-132
Identities = 321/1043 (30%), Positives = 477/1043 (45%), Gaps = 103/1043 (9%)
Query: 59 GPAAASAGSMVVDTPPTLPRHSSHLR------VARSPLHPGGTLWPGRVGRH-------- 104
GPAAA+ GS V PP + V+ + G + H
Sbjct: 31 GPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVP 90
Query: 105 -----SLYFNVTVFGKELHLRLRPNRRLVVPGSSVEW--QEDFRELFRQPLRQECVYTGG 157
SL+ + + H+ LR + LV PG V+ + + + P C Y G
Sbjct: 91 VSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGS 150
Query: 158 VTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEK-----EASGRTHVVYRRE-- 210
+ ++VA+S C GL+G+IRT+ D+F+ PL K + S +HV+Y+R
Sbjct: 151 LRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTE 210
Query: 211 ----------AVQQEWAEPDGDLHNEAFGLGDLPNL------------------LGLVGD 242
+ W LH+ LG LP L ++ D
Sbjct: 211 PHAPGASEVLVTSRTWELAHQPLHSSDLRLG-LPQKQHFCGRRKKYMPQPPKEDLFILPD 269
Query: 243 QLGDTERKRRHA----KPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDE 298
+ R +R + ++E L+VVD +++ HG E++ YVLT++N+V ++ D
Sbjct: 270 EYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDG 329
Query: 299 SLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVF 358
++G +INIA+V LI++ Q L+ + +L C+W +D HDH +
Sbjct: 330 TIGGNINIAIVGLILLEDEQP-GLVISHHADHTLSSFCQWQSGLMGKD---GTRHDHAIL 385
Query: 359 LTRQDF-----GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDG 413
LT D P G+AP++GMC RSC +N + G AF IAHE+GH GM HDG
Sbjct: 386 LTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 445
Query: 414 QGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDPFD-PAWPQ 470
+GN C + S G++M+P + F WS CS+ L ++L + CL D P +
Sbjct: 446 EGNMC--KKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKY 503
Query: 471 PPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGT 530
P +LPG Y + QC++ FG + C+ + CK LWC C+TK P +GT
Sbjct: 504 PEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK--CETKFMPAAEGT 561
Query: 531 ECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYG 590
C WC G C+ E G WS W+ + CSR+CGGGV RSR C NP P++G
Sbjct: 562 ICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
Query: 591 GRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCE 650
G+ C G ++CNS++CP DFRA QCA+ NS + + W PY +D C+
Sbjct: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRR-FRGRHYKWKPYTQVEDQDLCK 680
Query: 651 LICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCG 710
L C + ++ V DGT CS D +VC G C VGCD +GS +D CGVC
Sbjct: 681 LYCIAEGFDFFFSLSNKVKDGTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCN 739
Query: 711 GDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILN 770
G+NS C +G K +V IP+GAR I+I + S I V+N + ++
Sbjct: 740 GNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNG 799
Query: 771 PKGKEATSR-TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKY 829
+ R F+ ++ + + E+L +GP E + + L G +A++Y
Sbjct: 800 HWTVDWPGRYKFSGTTFDYRRSYNE-PENLIATGPTNETLIVELL---FQGRNPGVAWEY 855
Query: 830 VIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRH 889
+P +G+ +Y WA+ + CS +CGGG + GC R V
Sbjct: 856 -----SMPRLGTEK-QPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDL-KFQVNMS 907
Query: 890 LCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 949
C+ K RP C C P W W ACSR+CG G Q+R +QC + + V
Sbjct: 908 FCNPKTRPVTGLVPCKVSAC-PPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPV 965
Query: 950 MPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHC 1008
PA C P +R+ C CP W G W++CS TCG+G ++R V C+ TN ++
Sbjct: 966 -PASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL 1024
Query: 1009 EGD-------RPDTVQVCSLPAC 1024
D +P + C L C
Sbjct: 1025 LPDAVCTSEPKPRMHEACLLQRC 1047
Score = 80.9 bits (198), Expect = 7e-15
Identities = 51/193 (26%), Positives = 78/193 (40%), Gaps = 24/193 (12%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQR---HLCDHKKRPKPIRRRCNQHPCS 910
W+ WA CS CG G + C+ Q +C + +P+ + C C
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
Query: 911 QPV---WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRP--EARR 964
+P W+ W CS +C + G Q R ++C +G ++ + +K C+ +P E R
Sbjct: 1049 KPKKLQWLVSAWSQCSVTCER-GTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
Query: 965 PCLRVPCP------------AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC-EGD 1011
C +PCP W WSQC+A+CG G+Q R V C C
Sbjct: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
Query: 1012 RPDTVQVCSLPAC 1024
+P C+ C
Sbjct: 1168 KPSASLACNTHFC 1180
Score = 53.9 bits (128), Expect = 9e-07
Identities = 39/136 (28%), Positives = 53/136 (38%), Gaps = 24/136 (17%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRR---RDHHMVQRHLCDHKKRPK-PIRRRCNQHP 908
+W + +W+ CS C G Q C + + + C H +P + R C P
Sbjct: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
Query: 909 C-----------SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-A 956
C S+ W W C+ SCG GVQTR +QC L+ G PA C
Sbjct: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQC---LAGG----RPASGCLL 1165
Query: 957 GDRPEARRPCLRVPCP 972
+P A C CP
Sbjct: 1166 HQKPSASLACNTHFCP 1181
Score = 34.7 bits (78), Expect = 0.57
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 15/62 (24%)
Query: 556 GGW--SSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQ-----VCNSEE 608
G W S W++ C+ SCGGGV++RS C GGR G + + CN+
Sbjct: 1128 GSWFASPWSQ---CTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHF 1179
Query: 609 CP 610
CP
Sbjct: 1180 CP 1181
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 438 bits (1127), Expect = e-122
Identities = 324/1124 (28%), Positives = 500/1124 (44%), Gaps = 140/1124 (12%)
Query: 58 SGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKEL 117
SG AA S G+ PP P+ A+ P G + + F ++L
Sbjct: 127 SGAAALSPGAPASWQPPPPPQPPPSPPPAQHA-EPDGD---------EVLLRIPAFSRDL 176
Query: 118 HLRLRPNRRLVVPGSSVEWQED---------FRELFRQPLRQECVYTGGVTGMPGAAVAI 168
+L LR + R + P +VE + + P C YTG V PG+ +
Sbjct: 177 YLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASF 236
Query: 169 SNCDG-LAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEA 227
S C G L G I+ + FIEPL +G H VYR++ +E LH+
Sbjct: 237 STCGGGLMGFIQLNEDFIFIEPLN---DTMAITGHPHRVYRQKRSMEEKVTEKSALHS-- 291
Query: 228 FGLGDLPNLLGLVGDQ-------LGDTERKRRHAK--PGSYSIEVLLVVDDSVVRFHGKE 278
+ G++ D+ + ++ R +R++ P Y+IE ++V D ++V +HG +
Sbjct: 292 -------HYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGAD 344
Query: 279 HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRW 338
+ ++LT++N+V ++ +SL V +N+ +++LI++ + L + + LE C+W
Sbjct: 345 AARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILL-HETPPELYIGHHGEKMLESFCKW 403
Query: 339 AHSQ-QRQDPSHAEHH----------DHVVFLTRQDF-----GPSGMQGYAPVTGMCHPL 382
H + +++ H E D + +TR+DF P G A ++GMC
Sbjct: 404 QHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEK 463
Query: 383 RSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAA-FHRFHW 441
R C + ++G + AF IAHE GH +G+ HD CAD L + ++ W
Sbjct: 464 RKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD--GLHIMSGEWIKGQNLGDVSW 521
Query: 442 SRCSKLELSRYLPSY--DCLLDDPFDPAWPQ-------PPELPGINYSMDEQCRFDFGSG 492
SRCSK +L R+L S +CLL PQ P +LPG+ Y+ DEQC+ FG
Sbjct: 522 SRCSKEDLERFLRSKASNCLLQTN-----PQSVNSVMVPSKLPGMTYTADEQCQILFGPL 576
Query: 493 YQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKS--PEQ 550
C + C LWC + C+TK PP+DGT+C GKWC G C ++ PE
Sbjct: 577 ASFCQEMQHVI-CTGLWCK-VEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEH 634
Query: 551 TYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
G+ WS W+ CSR+C G+ SR R C P R C GP +Y++C + CP
Sbjct: 635 LAGE---WSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCP 686
Query: 611 GTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQK-CELICQSADTGDVVFMNQVVH 669
FR QC +Y V ++ + ++ D +K C L C + +++ V
Sbjct: 687 AGLPGFRDWQC---QAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVM 743
Query: 670 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 729
DGT C Y+ +CA G C VGCD +GS+ +D CGVC G+ C+ +KG ++
Sbjct: 744 DGTSCGYQG-LDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNH-TRG 801
Query: 730 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 789
AG ++++ IPAGAR I++ +E+ P + + G +N K S F G
Sbjct: 802 AGYVEVLVIPAGARRIKV--VEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVH 859
Query: 790 DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEM 849
E + GP + +L L + L Y+Y I D LP N
Sbjct: 860 YVRRGLWEKISAKGPTTAPLHLLVLLFQD--QNYGLHYEYTIPSDPLP---ENQSSKAPE 914
Query: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRR--RRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
+ W SW C CGGG + T C + ++ +V C + +P+P R+CN+
Sbjct: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
PC Q W+ EW CSR+CGK G+Q+R + C LSNGT + C G +P + + C
Sbjct: 975 PC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCE 1032
Query: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRT---------------NANSLGHCEGDR 1012
C W G WS+CS CG+GI+ R V C + C R
Sbjct: 1033 GQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWR 1092
Query: 1013 PDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEP-------LHP------INK 1059
CS+ CG Q+ ++ G + +P L P +N
Sbjct: 1093 MGDWSKCSI-TCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNT 1151
Query: 1060 ISS------TEPCTGDR-SVFCQMEVLDRYCSIPGYHRLCCVSC 1096
I+S T C GD+ V+C++ C +++ CC +C
Sbjct: 1152 ITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 437 bits (1125), Expect = e-122
Identities = 308/1025 (30%), Positives = 473/1025 (46%), Gaps = 102/1025 (9%)
Query: 30 HLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSP 89
H L +Y V P D G FLS+ + P +S +D
Sbjct: 44 HFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLD------------------ 85
Query: 90 LHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLR 149
G W +Y+ ++ K+L L N+ + +S ++ + L +
Sbjct: 86 ---GSEDW--------VYYRISHEEKDLFFNLTVNQGFL--SNSYIMEKRYGNLSHVKMM 132
Query: 150 QE----CVYTGGVT--GMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRT 203
C +G V G A+S C GL G + DFFIEP+++ E
Sbjct: 133 ASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKK-HPLVEGGYHP 191
Query: 204 HVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYS--- 260
H+VYRR+ V E EP GL D N+ +L + +R + S S
Sbjct: 192 HIVYRRQKVP-ETKEP-------TCGLKDSVNISQK--QELWREKWERHNLPSRSLSRRS 241
Query: 261 ------IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMV 314
+E L+V D ++ +HG E+V++Y+LT+MN+V ++H+ S+G I+I +VRLI++
Sbjct: 242 ISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILL 301
Query: 315 GYR-QSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-----GPSG 368
Q L ++ ++L C+W S + + HHD V LTR+D P
Sbjct: 302 EEEEQGLKIVHHAE--KTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCE 359
Query: 369 MQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 428
G + ++GMC P RSC +N + G AF IAHE GH G++HDG+ N C +M
Sbjct: 360 TLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIM 419
Query: 429 APLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCR 486
+ +Q WS+CS+ ++R+L CL D P PG+ Y + QC+
Sbjct: 420 SRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQ 479
Query: 487 FDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW- 545
+G C C+ LWCS FC++K DGT+C KWC G CI
Sbjct: 480 LQYGPNATFCQEVENV--CQTLWCSVKG---FCRSKLDAAADGTQCGEKKWCMAGKCITV 534
Query: 546 -KSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVC 604
K PE GGW W+ + CSR+CG GV+S R CNNP P +GG+ C G Y++C
Sbjct: 535 GKKPESI---PGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLC 591
Query: 605 NSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADTGDVVF 663
N C FR QC++ ++ ++N + W P + P A CEL C+ D
Sbjct: 592 NVHPCRSEAPTFRQMQCSEFDT-VPYKNELYHWFPIFNP---AHPCELYCRPIDGQFSEK 647
Query: 664 MNQVVHDGTRC-SYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGT 722
M V DGT C + +VC G C VGCD E+ S +D+CGVC GD S C+TV+
Sbjct: 648 MLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVR-K 706
Query: 723 LGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFT 782
+ K + +G + + IP GAR I++ +E + + + ++++ + LN + +
Sbjct: 707 MFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYK 766
Query: 783 AMGLEWEDAVEDAKESLKTSGPLPEAIAI-LALPPTEGGPRSSLAYKYVIHEDLLPLIGS 841
G ++ + E L +GP E++ I L T G + Y+Y I +D L
Sbjct: 767 LAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPG----IKYEYTIQKDGL----D 818
Query: 842 NNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIR 901
N+V E Y W W CS CG GI+ C ++ MV+ CD + +P +
Sbjct: 819 NDV---EQQMYFWQYGHWTECSVTCGTGIRRQTAHC-IKKGRGMVKATFCDPETQPNGRQ 874
Query: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
++C++ C P W EW ACS +CG G + R + C+ + + + P +P+
Sbjct: 875 KKCHEKAC-PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPK 933
Query: 962 ARRPCLR-VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDR-PDTVQVC 1019
C R + CP+ W +G WS+CS +CG G++ R V C N + C+ R P++ +C
Sbjct: 934 TLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE--PCDVTRKPNSRALC 991
Query: 1020 SLPAC 1024
L C
Sbjct: 992 GLQQC 996
Score = 101 bits (251), Expect = 5e-21
Identities = 79/271 (29%), Positives = 111/271 (40%), Gaps = 44/271 (16%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
W + +W+ CS CG G + + C + D C +RP P +R C+ PC+
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPAKR-CHLRPCAG-- 1367
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
W W CSR+C G + R IQC+ + + + AG P C PC A
Sbjct: 1368 WKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA 1426
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCE-GDRPDTVQVCS------------ 1020
W++ WSQCS +CG G+Q+R V C G C+ RP + C+
Sbjct: 1427 -WQVEPWSQCSRSCGGGVQERGVFCPG-----GLCDWTKRPTSTMSCNEHLCCHWATGNW 1480
Query: 1021 ---LPACGGNHQNSTVRADVWELGTPEGQ------WVPQSEPLHPIN----KISSTEPCT 1067
+CGG Q TV+ E E Q P+ N K S+ CT
Sbjct: 1481 DLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCT 1540
Query: 1068 GDR--SVFCQMEVLDRYCSIPGYHRLCCVSC 1096
D+ + FCQ + CS+P CC SC
Sbjct: 1541 KDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 47.8 bits (112), Expect = 7e-05
Identities = 24/55 (43%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1026
A W +G WS+CS TCG G R+V C T +S C RPD + C L C G
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQMDS--DCAAIQRPDPAKRCHLRPCAG 1367
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 435 bits (1119), Expect = e-121
Identities = 323/1071 (30%), Positives = 481/1071 (44%), Gaps = 140/1071 (13%)
Query: 82 HLRVARSPLHPGGTLWPGRVGRHS------LYFNVTVFGKELHLRLRPNRRLVVPGSSVE 135
H + R ++ WP S ++ ++ FG++ L N + P +V
Sbjct: 68 HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVT 127
Query: 136 ------------WQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDST 183
+ E+ EL + C Y G V IS C G+ G R+
Sbjct: 128 LLGTPGVNQTKFYSEEEAEL------KHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDG 181
Query: 184 DFFIEPLER--GQQEKEASGRTHVVYRREAVQQEWAEPDGDLH----------------- 224
D+FIEPL+ Q+++E + H++YRR A Q+E P H
Sbjct: 182 DYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQRE---PSTGRHACDTSEHKNRHSKDKKK 238
Query: 225 NEAFGLGDLPNLLGLV---------------GDQLGDTERKRRHAKPGSYS-----IEVL 264
A G+ NL G V G++ +T KR H + + +EVL
Sbjct: 239 TRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVL 298
Query: 265 LVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIE 324
+V D+ +V +HG E++Q+Y+LTLM+IV IY D S+G INI +V LI++ Q I
Sbjct: 299 VVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSIS 357
Query: 325 RGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF----GPSGMQGYAPVTGMCH 380
N +L+ C+W HS+ HHD V LTRQD G A + +C
Sbjct: 358 F-NAQTTLKNFCQWQHSKNSPG---GIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICD 413
Query: 381 PLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADE--TSLGSVMAPLVQAAFHR 438
P RSC+++ + G S+AF IAHE GHV M HD N C +E S VMAP + +
Sbjct: 414 PYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNFYTNP 472
Query: 439 FHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTC 496
+ WS+CS+ ++ +L + +CLL++P +P P +LPGI Y++++QC FG G Q C
Sbjct: 473 WMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVC 532
Query: 497 LAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQD 555
C++LWC++ + + C+T+ P DGTEC PGK C G C+ K + D
Sbjct: 533 PYMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPV-TD 588
Query: 556 GGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYED 615
G W SW+ FG+CSR+CGGG+++ R CN P P GG+ C+G +++ CN+E C D
Sbjct: 589 GSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRD 648
Query: 616 FRAQQCAKRNSYYVHQNA---KHSWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDG 671
FR +QCA + + + N WVP Y +C+L C+ A + V DG
Sbjct: 649 FRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDG 708
Query: 672 TRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAG 731
T C +D +C +G C GCD + S DKCGVCGGDNS C+TV GT + G
Sbjct: 709 TPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN--TVHYG 765
Query: 732 ALKLVQIPAGARHIQIE----ALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMG-- 785
+V+IPAGA +I + + E + + G F+LN ++ +G
Sbjct: 766 YNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNA 825
Query: 786 -LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNV 844
+E+ + E A E + ++ + + + + L G + +Y S N+
Sbjct: 826 VVEYSGS-ETAVERINSTDRIEQELLLQVL---SVGKLYNPDVRY-----------SFNI 870
Query: 845 LLEEM-DTYEW-ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRR 902
+E+ + W + W CSK C G + K C R D V CD +P I
Sbjct: 871 PIEDKPQQFYWNSHGPWQACSKPCQGE-RKRKLVCTRESDQLTVSDQRCDRLPQPGHITE 929
Query: 903 RCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQC--LLPLSNGTHKVMPAKACAGDRP 960
C C W CS CG LG +T I C L T KV + +P
Sbjct: 930 PCGT-DCDLR-WHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP 986
Query: 961 EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEGDRPDTVQ 1017
R C WR AW++CS +C G Q+R+ +C N + C T+Q
Sbjct: 987 SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQ 1046
Query: 1018 VCS---------------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEP 1053
CS L CG H++ V E + P+++P
Sbjct: 1047 RCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKP 1097
Score = 108 bits (270), Expect = 3e-23
Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
Query: 852 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
Y W + W C+K CG G ++ K C + V CD KRP R C+ PC
Sbjct: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNE-VHGARCDVSKRPVD-RESCSLQPCEY 1614
Query: 912 PVWVTEEWGACSRSCGKLGVQTRGIQC---LLPLSNGTHKVMPAKACAGDRPEARRPCLR 968
VW+T EW CS +CGK G + R + C N + C G +P + PC
Sbjct: 1615 -VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
Query: 969 VPCP--AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGD-RPDTVQVC 1019
CP A WR+G W CS +CG G+ QR V C TN + H C D +P+ + C
Sbjct: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
Score = 99.0 bits (245), Expect = 2e-20
Identities = 57/182 (31%), Positives = 83/182 (45%), Gaps = 16/182 (8%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
+W +W+ CS +CG G+Q GC+ H + + C+ RP+ R C C
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
Query: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCP 972
W EEW C+++CG+ G + R + C+ N H A+ RP R C PC
Sbjct: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCVDDNKNEVHG---ARCDVSKRPVDRESCSLQPCE 1613
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVC----------RTNANSLGHCEGDRPDTVQVCSLP 1022
W G WS+CS TCG+G +QR V C + + +C G +P +V C L
Sbjct: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
Query: 1023 AC 1024
C
Sbjct: 1674 DC 1675
Score = 97.8 bits (242), Expect = 6e-20
Identities = 62/177 (35%), Positives = 83/177 (46%), Gaps = 15/177 (8%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
W+ W+ CS +CG G + C + H+ + C H +P R+C C P
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHL-ESDYCKHLAKPHG-HRKCRGGRC--PK 1500
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCP 972
W W CS SCG+ GVQ R + C + GTHK+ C RPE+ R C CP
Sbjct: 1501 WKAGAWSQCSVSCGR-GVQQRHVGCQI----GTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 973 A-QWRLGAWSQCSATCGEGIQQRQVVC-RTNANSL--GHCE-GDRPDTVQVCSLPAC 1024
WR W +C+ TCGEG + R+VVC N N + C+ RP + CSL C
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 93.6 bits (231), Expect = 1e-18
Identities = 61/205 (29%), Positives = 89/205 (43%), Gaps = 18/205 (8%)
Query: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
E +T W +W CSK+C GG Q + C R + ++ C H++ K +RC++
Sbjct: 995 ECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQE--KVTIQRCSEF 1051
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
PC P W + +W C +CGK G + R + C G ++ +P + + C
Sbjct: 1052 PC--PQWKSGDWSECLVTCGK-GHKHRQVWCQF----GEDRLNDRMCDPETKPTSMQTCQ 1104
Query: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD-----RPDTVQVCSLP 1022
+ C A W+ G W QCS TCG+G Q R V C + D RP Q C LP
Sbjct: 1105 QPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP 1163
Query: 1023 ACGGNHQNSTVRADVWELGTPEGQW 1047
+C R + P QW
Sbjct: 1164 SCHPPPAAPETRRSTY--SAPRTQW 1186
Score = 89.0 bits (219), Expect = 3e-17
Identities = 73/236 (30%), Positives = 98/236 (41%), Gaps = 20/236 (8%)
Query: 780 TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPT-EGGPRSSLAYKYVIHEDLLPL 838
T M + + D V D E +PE ++ P + P S LA +ED P
Sbjct: 1260 TRQVMCVNYSDHVIDRSEC--DQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPR 1317
Query: 839 IGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPK 898
S + + +W W CS C GG Q C+ D + + C + +P
Sbjct: 1318 SASPS-RTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPD 1373
Query: 899 PIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG- 957
+R C PC P W WG C++ CG G++TR + C SNG P +C
Sbjct: 1374 E-QRACESGPC--PQWAYGNWGECTKLCGG-GIRTRLVVC--QRSNGER--FPDLSCEIL 1425
Query: 958 DRPEARRPCLRVPCP--AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD 1011
D+P R C CP A W G WS CS +CG G +QR V C S H E D
Sbjct: 1426 DKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGS--HLESD 1479
Score = 87.4 bits (215), Expect = 7e-17
Identities = 59/196 (30%), Positives = 87/196 (44%), Gaps = 33/196 (16%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
+W W+ C CG G + + C+ D + +CD + +P ++ C Q C+
Sbjct: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTSMQT-CQQPECAS- 1110
Query: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTH-KVMPAKAC-AGDRPEARRPCLRVP 970
W WG CS +CG+ G Q R ++C++ GT+ V+ C A RP + C
Sbjct: 1111 -WQAGPWGQCSVTCGQ-GYQLRAVKCII----GTYMSVVDDNDCNAATRPTDTQDCELPS 1164
Query: 971 C---PA--------------QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG--- 1010
C PA QWR G+W+ CSATCG+G + R V CR S+
Sbjct: 1165 CHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACAT 1224
Query: 1011 -DRPDTVQVCSLPACG 1025
RP + CS+ CG
Sbjct: 1225 LPRPVAKEECSVTPCG 1240
Score = 86.3 bits (212), Expect = 2e-16
Identities = 60/208 (28%), Positives = 80/208 (38%), Gaps = 45/208 (21%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
+W SW PCS CG G + CR + C RP + C+ PC Q
Sbjct: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRDENGS-VADESACATLPRPVA-KEECSVTPCGQ- 1241
Query: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDR-PEARRPCLRVPC 971
W +W +CS +CG+ G TR + C+ N + V+ C D PE + C PC
Sbjct: 1242 -WKALDWSSCSVTCGQ-GRATRQVMCV----NYSDHVIDRSECDQDYIPETDQDCSMSPC 1295
Query: 972 PA---------------------------------QWRLGAWSQCSATCGEGIQQRQVVC 998
P QWR G W CS+TC G Q+R VVC
Sbjct: 1296 PQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVC 1355
Query: 999 R-TNANSLGHC-EGDRPDTVQVCSLPAC 1024
+ N + C E +PD + C C
Sbjct: 1356 QDENGYTANDCVERIKPDEQRACESGPC 1383
Score = 80.1 bits (196), Expect = 1e-14
Identities = 60/199 (30%), Positives = 81/199 (40%), Gaps = 28/199 (14%)
Query: 847 EEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQ 906
++ + W W CS CG G Q C +V + C+ RP + C
Sbjct: 1104 QQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CEL 1162
Query: 907 HPCSQPV----------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVM 950
C P W W CS +CGK G + R + C NG+ V
Sbjct: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRD--ENGS--VA 1217
Query: 951 PAKACAG-DRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---G 1006
ACA RP A+ C PC QW+ WS CS TCG+G RQV+C ++ +
Sbjct: 1218 DESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRS 1276
Query: 1007 HCEGDR-PDTVQVCSLPAC 1024
C+ D P+T Q CS+ C
Sbjct: 1277 ECDQDYIPETDQDCSMSPC 1295
Score = 34.3 bits (77), Expect = 0.75
Identities = 30/108 (27%), Positives = 42/108 (38%), Gaps = 19/108 (17%)
Query: 484 QCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC 543
+C G GY+ L C +++ + Y +T P GT+ C+ C
Sbjct: 1623 ECSVTCGKGYKQRLV-----SCSEIYTGKENYEYSYQTTINCP--GTQPPSVHPCYLRDC 1675
Query: 544 IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSC--NNPSPAY 589
P + G W GSCS SCG GV RS C N P++
Sbjct: 1676 ----PVSATWRVGNW------GSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
Score = 32.7 bits (73), Expect = 2.2
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 546 KSPEQTYGQDGGWSSWT--KFGSCSRSCGGGVRSRSRSCNNPS-PAYGGRLC--LGPMFE 600
K EQ + G W +G C++ CGGG+R+R C + + C L +
Sbjct: 1371 KPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPD 1430
Query: 601 YQVCNSEECP 610
+ CN+ CP
Sbjct: 1431 REQCNTHACP 1440
Score = 32.3 bits (72), Expect = 2.8
Identities = 36/145 (24%), Positives = 50/145 (34%), Gaps = 40/145 (27%)
Query: 512 HPDNPYFCKTKKGPPLDGTECAP------GKWCFKGHCI-WKSPEQTYGQDGGWSSWTKF 564
H +C K G L+ C + C G C WK+ G WS
Sbjct: 1461 HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKA--------GAWSQ---- 1508
Query: 565 GSCSRSCGGGVR-------------SRSRSCNNPSPAYGGRLCLG---PMFEYQVCNSEE 608
CS SCG GV+ +R CN + R C G P++ ++ +E
Sbjct: 1509 --CSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQE 1566
Query: 609 CPGTYED---FRAQQCAKRNSYYVH 630
C T + +R C N VH
Sbjct: 1567 CTKTCGEGSRYRKVVCVDDNKNEVH 1591
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 431 bits (1108), Expect = e-120
Identities = 334/1067 (31%), Positives = 470/1067 (44%), Gaps = 131/1067 (12%)
Query: 100 RVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVT 159
R G +L ++ FG++L+L+LR + R + G VE R R + C Y+G V
Sbjct: 75 RPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPA--ELCFYSGRVL 132
Query: 160 GMPGAAVAISNCD---GLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEW 216
G PG+ V++S C GL GLI+ I+PL Q SGR H++ R+ ++
Sbjct: 133 GHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGP--FSGREHLIRRKWSLTPS- 189
Query: 217 AEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHA--KPGSYSIEVLLVVDDSVVRF 274
P + L + R+RR+A +++E L+V D +V++
Sbjct: 190 --PSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY 247
Query: 275 HGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQS-LSLIERGNPSRSLE 333
HG E Q ++LT+MN+V ++ +SLG+ INI + +L+++ R + LS+ G RSLE
Sbjct: 248 HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGE--RSLE 305
Query: 334 QVCRWAHSQ--------QRQDPSHAEHH---DHVVFLTRQDF-----GPSGMQGYAPVTG 377
C W + + Q P + D VF+TR DF P G A + G
Sbjct: 306 SFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGG 365
Query: 378 MCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFH 437
+C R C L ++G + AF IAHE GH LGM HD + CA + + S V+
Sbjct: 366 VCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMS--GEWVKGRNP 423
Query: 438 R-FHWSRCSKLELSRYLPSY--DCLL--DDPFDPAWPQPPELPGINYSMDEQCRFDFGSG 492
WS CS+ +L +L S CLL D P +LPG++YS +EQC+ FG
Sbjct: 424 SDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMN 483
Query: 493 YQTCLAFRTFEP--CKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQ 550
C R E C LWC + CKTK PPLDGTEC KWC G C+ K+P
Sbjct: 484 ATFC---RNMEHLMCAGLWCL-VEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIP 539
Query: 551 TYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
+ DG WS W + CSR+CG G R R R C+NP P GG C G E+ VC + CP
Sbjct: 540 EH-VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
Query: 611 GTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHD 670
FR QQC + + + V D + CEL C + + V D
Sbjct: 599 KGLPSFRDQQCQAHDRLSPKKKGLLTAVVV----DDKPCELYCSPLGKESPLLVADRVLD 654
Query: 671 GTRCSYRDPY--SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASK 728
GT C PY +C G+C +GCD +GS +D+CGVC GD C VKG A
Sbjct: 655 GTPCG---PYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHA-- 709
Query: 729 QAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEW 788
+ ALK +G I + K ++ G F + T+ + GL W
Sbjct: 710 RGTALK----DSGKGSINSD----------WKIELPGEFQI-----AGTTVRYVRRGL-W 749
Query: 789 EDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEE 848
E K S K LP + +L + G + Y+Y + + S ++
Sbjct: 750 E------KISAKGPTKLPLHLMVLLFHDQDYG----IHYEYTVPVNRTAENQSEPEKPQD 799
Query: 849 MDTYEWALKSWAPCSKACGGGIQFTKYGCRR--RRDHHMVQRHLCDHKKRPKPIRRRCNQ 906
+ W W CS CGGG + T C R + +V C RP+P RRCN
Sbjct: 800 -SLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
Query: 907 HPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPC 966
HPC Q WV W CS +C K G Q R + C+ L NGTH C G RP A + C
Sbjct: 859 HPC-QSRWVAGPWSPCSATCEK-GFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSC 916
Query: 967 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD-RPDTVQVCS----- 1020
C + W WSQCSA+CG+G+ +R V C NS G C+ RP + C
Sbjct: 917 EGQDCLSIWEASEWSQCSASCGKGVWKRTVAC---TNSQGKCDASTRPRAEEACEDYSGC 973
Query: 1021 -----------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPL-----------HPIN 1058
CG Q+ V+ G + S+P IN
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRIN 1033
Query: 1059 KISSTEP--------CTGDR-SVFCQMEVLDRYCSIPGYHRLCCVSC 1096
+ T P CT D+ +V+C++ C +++ CC +C
Sbjct: 1034 ANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC 1080
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 419 bits (1076), Expect = e-116
Identities = 279/900 (31%), Positives = 422/900 (46%), Gaps = 69/900 (7%)
Query: 150 QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLER--GQQEKEASGRTHVVY 207
+ C Y G V +S C GL G + + ++F+EP+ + G + ++ + H++Y
Sbjct: 127 RHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIY 186
Query: 208 RRE-------------AVQQEWAEPDGDLHNEAFGLGDL----PNLLGLVGDQ--LGDTE 248
R++ + + E H + DL +LG L D
Sbjct: 187 RQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDER 246
Query: 249 RKRRHAKPGSYS--IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINI 306
R R + SY IE+++ D VV HG ++QNY+LTLM+IV IY D S+G I+I
Sbjct: 247 RHSRKKRLISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHI 305
Query: 307 ALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGP 366
+V+L+M+ +R+ + + + +L+ C W +Q D H HHD V +TR+D
Sbjct: 306 VVVKLVMI-HREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICS 364
Query: 367 S----GMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADET 422
S M G + + +C PL+SC +N E G SAF IAHE GH LG++HD +
Sbjct: 365 SKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKV 424
Query: 423 SLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYS 480
+ VMAP + + WS CS+ ++ +L + +CLLD P + + P ELPG Y
Sbjct: 425 TKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYD 484
Query: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWCF 539
++QC FG G Q C C LWC+ + + C T+ PP DGT+C PG C
Sbjct: 485 GNKQCELAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCR 541
Query: 540 KGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMF 599
G C+ K E T +G W W + SCSR+CGGG+ S +R CN P P GG C+G
Sbjct: 542 HGLCVNKETE-TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRM 600
Query: 600 EYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHS---WVP-YEPDDDAQKCELICQS 655
+++ CN++ CP +DFR +QC+ N ++ + S W+P Y +C+L CQ
Sbjct: 601 KFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQV 660
Query: 656 ADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSH 715
A T + +V DGT C + + +C +G+C+ GCD + S DKCGVCGGDNS
Sbjct: 661 AGTNYFYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSS 719
Query: 716 CRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKS---PHRIVVKNQVTGSFILNPK 772
C+T+ G S G +V+IPAGA ++ I S + + G+F+ N
Sbjct: 720 CKTITGVFN--SSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGN 777
Query: 773 GKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 832
+TS+ E V+ + ++ SG A+ + T + + +
Sbjct: 778 FLLSTSKK--------EINVQGTRTVIEYSG---SNNAVERINSTNRQEKELILQVLCVG 826
Query: 833 EDLLPLIG-SNNVLLEE-MDTYEW-ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRH 889
P + S N+ LEE D + W W C+K C G+Q C + DH +V
Sbjct: 827 NLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDK 885
Query: 890 LCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 949
CDH P + + CN + W CS CG+ G +T I C+ + V
Sbjct: 886 ECDHLPLPSFVTQSCNTD--CELRWHVIGKSECSSQCGQ-GYRTLDIHCMKYSIHEGQTV 942
Query: 950 MPAKACAGD--RPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH 1007
GD +P + C +W WSQCS +CG G + R+ C N+ GH
Sbjct: 943 QVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYC---MNNFGH 999
Score = 95.5 bits (236), Expect = 3e-19
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 8/148 (5%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
+W +W CS+ CGGGI+ C+ +++ H C+ +P P +C+ H C
Sbjct: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ-ILEDHNCEIVNKP-PSVIQCHMHACPAD 1418
Query: 913 V-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
V W E W +CS SCGK G + R + C+ K+ +P + C V C
Sbjct: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
Query: 972 PAQWRLGAWSQCSATCGEGIQQRQVVCR 999
P+ W+ +W++CS TCG G+QQR V CR
Sbjct: 1475 PS-WKANSWNECSVTCGSGVQQRDVYCR 1501
Score = 92.0 bits (227), Expect = 3e-18
Identities = 60/219 (27%), Positives = 89/219 (40%), Gaps = 45/219 (20%)
Query: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
E WA W+ C CG G + + C+ DH + C+ +P+ + C H
Sbjct: 1019 EFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLSP-CELH 1075
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPC 966
C+ W WG C+ +CG G Q R ++C+ L++ V+ C RP R+ C
Sbjct: 1076 TCAS--WQVGPWGPCTTTCGH-GYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSC 1129
Query: 967 LRVPCP------------------AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC 1008
+ PC AQWR G+W+ CS +CG G Q R V CR + +
Sbjct: 1130 VLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIA-- 1187
Query: 1009 EGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQW 1047
D LP A++W+ TP G+W
Sbjct: 1188 -----DESYCAHLPR----------PAEIWDCFTPCGEW 1211
Score = 91.3 bits (225), Expect = 5e-18
Identities = 55/176 (31%), Positives = 74/176 (42%), Gaps = 16/176 (9%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
W W+ CS++CGGG + + C H + C R R CN+ C P
Sbjct: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNE-CQELSR--VTRENCNEFSC--PS 1024
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
W EW C +CGK G + R + C L + + + + +PE+ PC C A
Sbjct: 1025 WAASEWSECLVTCGK-GTKQRQVWCQLNVDH----LSDGFCNSSTKPESLSPCELHTC-A 1078
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSL----GHC-EGDRPDTVQVCSLPAC 1024
W++G W C+ TCG G Q R V C S C E RP Q C L C
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/240 (27%), Positives = 103/240 (42%), Gaps = 25/240 (10%)
Query: 805 LPEAIAILALPPTEGG-PRSSLAYKYVIHEDLLPLI-----GSNNVLLEEMDTYEWALKS 858
+ + ++ A PP P S + Y + +L PL N V+ + +W
Sbjct: 1254 MEQECSLAACPPAHSHFPSSPVQPSYYLSTNL-PLTQKLEDNENQVVHPSVRGNQWRTGP 1312
Query: 859 WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEE 918
W CS +C GG+Q C +D + CD +P P ++C PC P W
Sbjct: 1313 WGSCSSSCSGGLQHRAVVC---QDENGQSASYCDAASKP-PELQQCGPGPC--PQWNYGN 1366
Query: 919 WGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCPA--QW 975
WG CS++CG G+++R + C P NG +++ C ++P + C CPA W
Sbjct: 1367 WGECSQTCGG-GIKSRLVICQFP--NG--QILEDHNCEIVNKPPSVIQCHMHACPADVSW 1421
Query: 976 RLGAWSQCSATCGEGIQQRQVVC----RTNANSLGHCEGDRPDTVQVCSLPACGGNHQNS 1031
W+ CSA+CG+G + R+V C + + +P T + C C NS
Sbjct: 1422 HQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANS 1481
Score = 83.6 bits (205), Expect = 1e-15
Identities = 59/198 (29%), Positives = 79/198 (39%), Gaps = 29/198 (14%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS--- 910
W + W PC+ CG G Q C +++ C RP R+ C PCS
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
Query: 911 --------------QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA 956
W W CS SCG+ G Q R + C + ++ CA
Sbjct: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSC----RDALDRIADESYCA 1193
Query: 957 G-DRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL--GHCEGD-R 1012
RP C PC +W+ G WS CSA+CG G RQV+C + +C+ + R
Sbjct: 1194 HLPRPAEIWDCF-TPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
Query: 1013 PDTVQVCSLPACGGNHQN 1030
P Q CSL AC H +
Sbjct: 1252 PLMEQECSLAACPPAHSH 1269
Score = 80.5 bits (197), Expect = 9e-15
Identities = 63/217 (29%), Positives = 87/217 (40%), Gaps = 56/217 (25%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC--- 909
EW W+PCS +CG G + C H + + CD + RP + + C+ C
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNY--HQPIDENYCDPEVRPL-MEQECSLAACPPA 1266
Query: 910 -----SQPV--------------------------------WVTEEWGACSRSCGKLGVQ 932
S PV W T WG+CS SC G+Q
Sbjct: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG-GLQ 1325
Query: 933 TRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGI 991
R + C NG A C A +P + C PCP QW G W +CS TCG GI
Sbjct: 1326 HRAVVC--QDENG----QSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGI 1378
Query: 992 QQRQVVCRTNANSL---GHCE-GDRPDTVQVCSLPAC 1024
+ R V+C+ + +CE ++P +V C + AC
Sbjct: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
Score = 51.6 bits (122), Expect = 5e-06
Identities = 36/111 (32%), Positives = 48/111 (43%), Gaps = 20/111 (18%)
Query: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
+ C PC+ V VT + C+ +CG + R C S HK+ RP
Sbjct: 1581 KNCRNPPCNYIV-VTADSSQCANNCG-FSYRQRITYCTEIPSTKKHKLHRL------RPI 1632
Query: 962 ARRPCLRVPCP------------AQWRLGAWSQCSATCGEGIQQRQVVCRT 1000
+ C VP A W++G WS+CS TCG GI +RQV C T
Sbjct: 1633 VYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCIT 1683
Score = 36.2 bits (82), Expect = 0.20
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 8/55 (14%)
Query: 561 WTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEY-----QVCNSEECP 610
++++ CSRSCGGG RSR C N +G RL E + CN CP
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMN---NFGHRLADNECQELSRVTRENCNEFSCP 1023
Score = 34.7 bits (78), Expect = 0.57
Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 20/69 (28%)
Query: 518 FCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577
+C PP + +C PG P+ YG +G CS++CGGG++S
Sbjct: 1341 YCDAASKPP-ELQQCGPGP----------CPQWNYGN---------WGECSQTCGGGIKS 1380
Query: 578 RSRSCNNPS 586
R C P+
Sbjct: 1381 RLVICQFPN 1389
Score = 32.3 bits (72), Expect = 2.8
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 12/82 (14%)
Query: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLC---LGPMFEYQVCNSEECP 610
Q G WS CS SCG G +R C N C + P+ E Q C+ CP
Sbjct: 1212 QAGDWSP------CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLME-QECSLAACP 1264
Query: 611 GTYEDFRAQQCAKRNSYYVHQN 632
+ F + + SYY+ N
Sbjct: 1265 PAHSHFPSSPV--QPSYYLSTN 1284
Score = 32.3 bits (72), Expect = 2.8
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 564 FGSCSRSCGGGVRSRSRSC---NNPSPAYGGRLCLGPMFEYQVCNSEECP 610
+GSCS SC GG++ R+ C N S +Y P E Q C CP
Sbjct: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPP--ELQQCGPGPCP 1360
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 397 bits (1021), Expect = e-110
Identities = 292/941 (31%), Positives = 422/941 (44%), Gaps = 102/941 (10%)
Query: 98 PGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLR-------- 149
P G L F +T F ++ +L L P+ + + P S E PL+
Sbjct: 45 PEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEH-------LGVPLQGLTGGSSD 97
Query: 150 -QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQE--KEASGRTHVV 206
+ C Y+G V P + A+S C GL G ++ I PL + S H++
Sbjct: 98 LRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLL 157
Query: 207 YRREAVQQEWAEPDGDLHNEA-FGLGDLPNLLGLVGDQ------LGDTERKRRHAKPGSY 259
RR P GD + G P +L + G++ +RR + +
Sbjct: 158 QRRGVP----GGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF 213
Query: 260 S-----IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMV 314
+E L+V D+S+V+FHG + +++Y+LTL+ +Y S+ INI +V+++++
Sbjct: 214 VSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLL 272
Query: 315 GYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS---GMQG 371
R S + GN + +L C W + H E+ D + TRQD + G
Sbjct: 273 RDRDSGPKVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLG 331
Query: 372 YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD---ETSLGSVM 428
A V MC P RSC++ +DG SAF AHE GHV M HD C + + +M
Sbjct: 332 MADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNV-KVCEEVFGKLRANHMM 390
Query: 429 APLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCR 486
+P + WS CS ++ +L S DCLLD P P P +LPG +Y++ +QC
Sbjct: 391 SPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCE 449
Query: 487 FDFGSGYQTCLAFRTFEPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW 545
FG G + C + C +LWC+ C+T+ P DGT C GK C KG C+
Sbjct: 450 LAFGVGSKPC---PYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVE 506
Query: 546 KSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCN 605
+ + DG W+ W +G CSR+CGGGV+ R C NP+PA GG+ C G +Y+ CN
Sbjct: 507 RHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCN 566
Query: 606 SEECPGTY--EDFRAQQCAKRNSYYVHQN---AKHSWVP-YEPDDDAQKCELICQSADTG 659
E CP + + FR +QC N Y N +WVP Y KC+LIC++ TG
Sbjct: 567 LEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTG 626
Query: 660 DVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTV 719
+ V DGT CS D SVC +G+C+ GCD +GS K DKCGVCGGDN C+ V
Sbjct: 627 YFYVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKV 685
Query: 720 KGTLGKASKQAGALKLVQIPAGARHIQI-----EALEKSPHRIVVKNQVTGSFILNPK-G 773
G K G +V IPAGA I I + L + + +KN G ++LN
Sbjct: 686 TGLFTK--PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS-QGKYLLNGHFV 742
Query: 774 KEATSRTFTAMG-LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKY--- 829
A R G L A ESL+ S P+ E + + L + P + Y +
Sbjct: 743 VSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTP-PRVRYSFYLP 801
Query: 830 ------------------VIHEDLLPLIGSNNV-LLEEMDTYEWALKSWAPCSKACGGGI 870
V+H +L L SN V ++ W SW PCS +CG G+
Sbjct: 802 KEPREDKSSHPKDPRGPSVLHNSVLSL--SNQVEQPDDRPPARWVAGSWGPCSASCGSGL 859
Query: 871 QFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLG 930
Q CR V CD R P+ + PC P W W CS+SCG+ G
Sbjct: 860 QKRAVDCRGSAGQRTVP--ACDAAHR--PVETQACGEPC--PTWELSAWSPCSKSCGR-G 912
Query: 931 VQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
Q R ++C + +G + + +P+ C+ PC
Sbjct: 913 FQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 67.8 bits (164), Expect = 6e-11
Identities = 43/116 (37%), Positives = 52/116 (44%), Gaps = 13/116 (11%)
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCP 972
WV WG CS SCG G+Q R + C G+ AC A RP + C PCP
Sbjct: 843 WVAGSWGPCSASCGS-GLQKRAVDC-----RGSAGQRTVPACDAAHRPVETQACGE-PCP 895
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEGDR-PDTVQVCSLPAC 1024
W L AWS CS +CG G Q+R + C + L C R P + C L C
Sbjct: 896 T-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 48.5 bits (114), Expect = 4e-05
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 972 PAQWRLGAWSQCSATCGEGIQQRQVVCRTNA--NSLGHCE-GDRPDTVQVCSLP 1022
PA+W G+W CSA+CG G+Q+R V CR +A ++ C+ RP Q C P
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP 893
Score = 38.1 bits (87), Expect = 0.052
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 42/176 (23%)
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
PC + T+ W ++ G++ QTR P ++GT +C + CL
Sbjct: 458 PCPYMQYCTKLW-CTGKAKGQMVCQTRHF----PWADGT-------SCGEGKL-----CL 500
Query: 968 RVPCPAQWRL------GAWSQ------CSATCGEGIQ--QRQVVCRTNANSLGHCEGDRP 1013
+ C + L G+W++ CS TCG G+Q +RQ T AN +CEG R
Sbjct: 501 KGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV 560
Query: 1014 DTVQVCSLPACGGNHQNSTVRADVWELG----------TPEGQWVPQSEPLHPINK 1059
+ C+L C + + R + E T WVP+ + P +K
Sbjct: 561 -KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDK 615
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 377 bits (968), Expect = e-104
Identities = 267/897 (29%), Positives = 406/897 (45%), Gaps = 89/897 (9%)
Query: 102 GRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQ----ECVYTGG 157
G + + F ++L L LRP+ + PG +++ + PL + C Y+G
Sbjct: 70 GHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQ-NVGRKSGSETPLPETDLAHCFYSGT 128
Query: 158 VTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASG---------RTHVVYR 208
V G P +A A+S C+G+ G +FI+PL + + + H++ R
Sbjct: 129 VNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRR 188
Query: 209 RE--------AVQQEWAEPDGDLHNEAFGLGDL------------PNLLGLVGDQLGDTE 248
V + P G E G P L G VG G
Sbjct: 189 NRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQG-VGQPTGTGS 247
Query: 249 -RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIA 307
RK+R Y +E +LV D S+ FHG +++Y+LTL ++ +Y S+ +++
Sbjct: 248 IRKKRFVSSHRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLV 305
Query: 308 LVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS 367
+V+++++ Q + N + +L C W AEH+D + TRQD S
Sbjct: 306 VVKILVIHDEQKGPEVT-SNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGS 364
Query: 368 ---GMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSL 424
G A V +C P RSC++ +DG +AF AHE GHV M HD CA +
Sbjct: 365 QTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGV 423
Query: 425 GS---VMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINY 479
+MA ++ H WS CS ++ +L + +CL+D P +P P +LPG +Y
Sbjct: 424 NQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI-QLPGDLPGTSY 482
Query: 480 SMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWC 538
+ QC+F FG + C + C LWC+ C+TK P DGT C GKWC
Sbjct: 483 DANRQCQFTFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC 540
Query: 539 FKGHCIWKSPEQTYGQD--GGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLG 596
G C+ K+ + + G W W +G CSR+CGGGV+ R C+NP P GG+ C G
Sbjct: 541 INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG 600
Query: 597 PMFEYQVCNSEECP-GTYEDFRAQQCAKRNSY---YVHQNAKHSWVP-YEPDDDAQKCEL 651
Y+ CN E+CP + FR +QC N + W+P Y +C+L
Sbjct: 601 KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL 660
Query: 652 ICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGG 711
ICQ+ G + V DGT CS D SVC +G+CV GCD+ + S K DKCGVCGG
Sbjct: 661 ICQAKGIGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGG 719
Query: 712 DNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHR----IVVKNQVTGSF 767
+ S C+ + G++ S + G ++ IP GA +I+++ + R + G++
Sbjct: 720 NGSTCKKISGSV--TSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTY 777
Query: 768 ILNPKGKEATSR---TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGP-RS 823
ILN +T + + L + + A E +++ PL E + I L T G R
Sbjct: 778 ILNGDYTLSTLEQDIMYKGVVLRYSGS-SAALERIRSFSPLKEPLTIQVL--TVGNALRP 834
Query: 824 SLAYKYVIHEDLLPLIGSNNVLLEEMDTYE-WALKSWAPCSKACGGGIQFTKYGCRRRRD 882
+ Y Y + + + T+ W ++ W CSK+C G Q C RD
Sbjct: 835 KIKYTYFVKK--------KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC---RD 883
Query: 883 HHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCL 939
+ C + +P R C HPC P W EW +CS++CGK G + R ++CL
Sbjct: 884 INGQPASECAKEVKPAS-TRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCL 936
Score = 80.9 bits (198), Expect = 7e-15
Identities = 42/86 (48%), Positives = 54/86 (62%), Gaps = 9/86 (10%)
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD-RPEARRPCLRVPCP 972
WV EEWG CS+SC +LG Q R ++C NG PA CA + +P + RPC PCP
Sbjct: 858 WVIEEWGECSKSC-ELGWQRRLVECRD--ING----QPASECAKEVKPASTRPCADHPCP 910
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVC 998
QW+LG WS CS TCG+G ++R + C
Sbjct: 911 -QWQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 37.4 bits (85), Expect = 0.088
Identities = 28/100 (28%), Positives = 39/100 (39%), Gaps = 15/100 (15%)
Query: 970 PCPAQWRL-GAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPACGG 1026
P W + G W CS TCG G+Q C G +CEG R + C+L C
Sbjct: 557 PFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRV-RYRSCNLEDCPD 615
Query: 1027 NHQNSTVRADVWEL----------GTPEGQWVPQSEPLHP 1056
N+ T R + E P +W+P+ + P
Sbjct: 616 NN-GKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSP 654
Score = 33.9 bits (76), Expect = 0.98
Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 969 VPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHCEGD-RPDTVQVCSLPAC 1024
+P + W + W +CS +C G Q+R V CR N C + +P + + C+ C
Sbjct: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPC 909
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 364 bits (935), Expect = e-100
Identities = 266/842 (31%), Positives = 391/842 (46%), Gaps = 83/842 (9%)
Query: 95 TLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVE-WQEDFRELFRQPLRQECV 153
T PG G +L+ ++ FGK LRL P+ + P +E R + + C
Sbjct: 44 TRLPGSAGELALH--LSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCF 101
Query: 154 YTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEP-----------------------L 190
++G V G P + A+S C GL+G D +F I+P L
Sbjct: 102 FSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPL 161
Query: 191 ERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERK 250
RG + + +G R+E + + EA G + P LG T R
Sbjct: 162 PRGPEWEVETGEGQ---RQERGDHQEDSEEESQEEEAEGASEPP-------PPLGATSRT 211
Query: 251 RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVR 310
+R + +E LLV D S+ F+G + +QN++LTLM++ IY S+ IN+ +V+
Sbjct: 212 KRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLMVVK 269
Query: 311 LIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-GPSGM 369
+++V + + N +L C W + H EH+D + LTRQ+F G G+
Sbjct: 270 VLIVEDEKWGPEVS-DNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGL 328
Query: 370 ---QGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGS 426
G A + +C P +SC++ ++G +A +AHE GHVL M HD +G
Sbjct: 329 CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGK 388
Query: 427 --VMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPG--INYS 480
VMAPL WS CS + L+ L DCLLD P A P P LPG Y
Sbjct: 389 HHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPA-AALPLPTGLPGRMALYQ 447
Query: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKG--PPLDGTECAPGKWC 538
+D+QCR FG ++ C + C QLWC C TK G P DGT C PG C
Sbjct: 448 LDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLC 507
Query: 539 FKGHCIWKSPEQTYGQ-----DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRL 593
+G C+ PE+ + DGGW+ W +G CSR+CGGGV+ R C +P P GGR
Sbjct: 508 SEGSCL---PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
Query: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY-YVHQNAK-HSWVP-YEPDDDAQKCE 650
CLG +YQ C++EECP + FR QQC K N+Y Y + WVP Y +C+
Sbjct: 565 CLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK 624
Query: 651 LICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCG 710
L C++ + V DGT C + ++C RG+CV GCD V S + DKCGVCG
Sbjct: 625 LFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCG 683
Query: 711 GDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIE-----ALEKSPHRIVVKNQVTG 765
G + CR V G+L G +V IPAGA +I ++ ++ + + +K G
Sbjct: 684 GKGNSCRKVSGSL--TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKT-ADG 740
Query: 766 SFILNPK-GKEATSRTFTAMG--LEWEDAVEDAKESLKTSGPLPEAIAI-LALPPTEGGP 821
++LN A + G L++ ++ E L++ PLPE + + L P E P
Sbjct: 741 QYLLNGNLAISAIEQDILVKGTILKYSGSIA-TLERLQSFRPLPEPLTVQLLTVPGEVFP 799
Query: 822 RSSLAYKYVIHEDLLPLIGSNNV-----LLEEMDTYEWALKSWAPCSKACGGGIQFTKYG 876
+ Y + + D+ + S+ +++ + +W L W+ CS CG G Q
Sbjct: 800 -PKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVE 858
Query: 877 CR 878
CR
Sbjct: 859 CR 860
Score = 45.4 bits (106), Expect = 3e-04
Identities = 24/56 (42%), Positives = 29/56 (51%), Gaps = 7/56 (12%)
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVCR-------TNANSLGHCEGDRPDTVQVCSL 1021
AQW LG WS+CS+TCG G Q+R V CR N E +P Q+C L
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL 889
Score = 33.5 bits (75), Expect = 1.3
Identities = 37/151 (24%), Positives = 53/151 (35%), Gaps = 23/151 (15%)
Query: 926 CGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL-----RVPCP------AQ 974
C +L T G + L NG+ C + CL P P A
Sbjct: 472 CAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAP 531
Query: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPACGGN----H 1028
W G W +CS TCG G+Q C+ G +C G R Q C C +
Sbjct: 532 W--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRA-KYQSCHTEECPPDGKSFR 588
Query: 1029 QNSTVRADVWELGTPEG---QWVPQSEPLHP 1056
+ + + + +G QWVP+ + P
Sbjct: 589 EQQCEKYNAYNYTDMDGNLLQWVPKYAGVSP 619
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 362 bits (929), Expect = 1e-99
Identities = 249/803 (31%), Positives = 365/803 (45%), Gaps = 91/803 (11%)
Query: 131 GSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPL 190
G+S W+ R C Y G V G P + C GL G + ++PL
Sbjct: 119 GTSAPWRH----------RSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPL 168
Query: 191 ERGQQEKEASGRTHV--------VYRREAVQQEWAEPDG---------DLHNEAFGLGDL 233
RG +E GR + VY RE E P + H A +
Sbjct: 169 LRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSN- 227
Query: 234 PNLLGLVGDQLGDTE--------------RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEH 279
P+ + QL D R+RR + + +E+LLV D S+ R +G+
Sbjct: 228 PSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG- 286
Query: 280 VQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWA 339
+Q+Y+LTL +I + +Y S+ HI +A+V+++++G + SL N + +L+ C+W
Sbjct: 287 LQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDK-SLEVSKNAATTLKNFCKWQ 345
Query: 340 HSQQRQDPSHAEHHDHVVFLTRQDF---GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSA 396
H + H EH+D + TR+D G A V +C P RSCA+ +DG +A
Sbjct: 346 HQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAA 405
Query: 397 FVIAHETGHVLGMEHDGQGNGCADETSLGS-----VMAPLVQAAFHRFHWSRCSKLELSR 451
F +AHE GH+LG+ HD C E + GS +M+ ++ + WS+C+ ++
Sbjct: 406 FTVAHEIGHLLGLSHD-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITE 462
Query: 452 YLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLW 509
+L +CLLD P P ELPG Y +QC FG Y C + C +LW
Sbjct: 463 FLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLW 518
Query: 510 CSHP-DNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQD--GGWSSWTKFGS 566
C+ C TKK P ++GT C G+ C +G C+ K+ ++ Y G W SW +G
Sbjct: 519 CAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQ 578
Query: 567 CSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNS 626
CSRSCGGGV+ R CNNP+P GR C G Y+ C+ CP + FR +QC +N
Sbjct: 579 CSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
Query: 627 YYVHQNAKH-----SWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPY 680
Y +AK WVP Y A C+L C++ TG V + V DGT C
Sbjct: 639 Y--QSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYS-N 695
Query: 681 SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPA 740
SVC RG+CV GCD +GS DKCGVCGGDNS C + GT K SK G +V+IP
Sbjct: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSK--GYTDVVRIPE 753
Query: 741 GARHIQIEALEKSPH----RIVVKNQVTGSFILNPKGKEATSRTF-----TAMGLEWEDA 791
GA HI++ + + + G +++N K +TS T T M
Sbjct: 754 GATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSH 813
Query: 792 VEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGS-----NNVLL 846
+D + S + I I+ + T+ + Y + + + P + S +N +
Sbjct: 814 RDDFLHGMGYSA--TKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVG 871
Query: 847 EEMDTYEWALKSWAPCSKACGGG 869
+W W CS+ C G
Sbjct: 872 SHTSQPQWVTGPWLACSRTCDTG 894
Score = 45.1 bits (105), Expect = 4e-04
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 8/63 (12%)
Query: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLR 968
SQP WVT W ACSR+C G TR +QC +G K+ AK C RP A + CL
Sbjct: 875 SQPQWVTGPWLACSRTC-DTGWHTRTVQC----QDGNRKL--AKGCPLSQRPSAFKQCLL 927
Query: 969 VPC 971
C
Sbjct: 928 KKC 930
Score = 37.4 bits (85), Expect = 0.088
Identities = 27/72 (37%), Positives = 31/72 (43%), Gaps = 11/72 (15%)
Query: 919 WGACSRSCGKLGVQTRGIQC--LLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQWR 976
WG CSRSCG GVQ C P +NG + C G R R C +PCP +
Sbjct: 576 WGQCSRSCGG-GVQFAYRHCNNPAPRNNGRY-------CTGKR-AIYRSCSLMPCPPNGK 626
Query: 977 LGAWSQCSATCG 988
QC A G
Sbjct: 627 SFRHEQCEAKNG 638
Score = 35.8 bits (81), Expect = 0.26
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 5/52 (9%)
Query: 858 SWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
SW CS++CGGG+QF C + C K + I R C+ PC
Sbjct: 575 SWGQCSRSCGGGVQFAYRHCNNPAPRN--NGRYCTGK---RAIYRSCSLMPC 621
Score = 35.4 bits (80), Expect = 0.34
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 978 GAWSQCSATCGEGIQQRQVVCRTNA--NSLGHCEGDRPDTVQVCSLPACGGN 1027
G+W QCS +CG G+Q C A N+ +C G R + CSL C N
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRA-IYRSCSLMPCPPN 624
Score = 35.4 bits (80), Expect = 0.34
Identities = 19/53 (35%), Positives = 21/53 (39%), Gaps = 2/53 (3%)
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSL--GHCEGDRPDTVQVCSLPAC 1024
QW G W CS TC G R V C+ L G RP + C L C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 330 bits (846), Expect = 5e-90
Identities = 245/811 (30%), Positives = 371/811 (45%), Gaps = 61/811 (7%)
Query: 249 RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
+++R A G +E+L+ V V + H +E + YVLT +NI E+ D SLG + L
Sbjct: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
Query: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF---- 364
V+++++ + I N + SL VC W+ + +D + H D V+++TR D
Sbjct: 129 VKMVILTEPEGAPNI-TANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 365 GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDG-QGNGCADETS 423
G ++G + G C P SC + + GF IAHE GH G+EHDG G+GC
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
Query: 424 LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPS--YDCLLDDPF---DPAWPQPPELPGIN 478
G VMA A WS CS+ +L L + C+ D P A P PG+
Sbjct: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLY 304
Query: 479 YSMDEQCRFDFGSGYQTC-LAFRTFEPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAPGK 536
YS +EQCR FG C A + C+ L C + P + C P LDGTEC K
Sbjct: 305 YSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEK 364
Query: 537 WCFKGHC---IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRL 593
WC KG C + +P G WSSW CSRSCGGGV +R R CNNP PA+GGR
Sbjct: 365 WCSKGRCRSLVELTP--IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRA 422
Query: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDA 646
C+G + ++CN++ C T +F +QQCA+ + + + + + W VP+ D
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD-- 480
Query: 647 QKCELICQSADTGDVVFMNQVVHDGTRCSYRDP-----YSVCARGECVPVGCDKEVGSMK 701
C +C++ ++ DGTRC P S+C G C GCD + S +
Sbjct: 481 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 540
Query: 702 ADDKCGVCGGDNSHCRTVKG--TLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVV 759
D+C VCGGDNS C KG T G+A + L + + ++ + HR +
Sbjct: 541 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP--------NLTSVYIANHRPLF 592
Query: 760 KN---QVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPP 816
+ ++ G +++ K + + T+ ++ ED + + +L T LP I P
Sbjct: 593 THLAVRIGGRYVVAGKMSISPNTTYPSL---LEDGRVEYRVAL-TEDRLPRLEEIRIWGP 648
Query: 817 TEGGPRSSLAYKYVIHEDLL--PLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 874
+ + +Y L P I + + WA PCS +CG G+++
Sbjct: 649 LQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVN 707
Query: 875 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTR 934
Y C + +V+ C ++P C PC P W ++G CS SCG G++ R
Sbjct: 708 YSCLDQARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSASCGG-GLRER 765
Query: 935 GIQCLLPLSNGTHKVMPAKACAGDRPE--ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQ 992
++C+ + + PA+ AG + A C PCPA+W + S C++ G G+
Sbjct: 766 PVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLA 825
Query: 993 QRQVVCRTNANSLGHCEGDRPDTVQVCSLPA 1023
C A+ L + P +V LPA
Sbjct: 826 LENETCVPGADGLEAPVTEGPGSVDE-KLPA 855
Score = 88.6 bits (218), Expect = 3e-17
Identities = 65/196 (33%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 860 APCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKPIRRRCNQHPCSQPVWV 915
A CS +CG G+ C R + L C RP+P + C+ PC P W
Sbjct: 960 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWK 1017
Query: 916 TEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLRVPCPAQ 974
G CS SCG LG R + C+ L G + ACA RPEA PCL C +
Sbjct: 1018 VMSLGPCSASCG-LGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR 1075
Query: 975 WRLGAWSQCSATCGEGIQQRQVVC-------RTNANSLGHCEGDRPDTVQVC------SL 1021
W +G W +CS +CG+GIQ+R+ C A+ H +P TV+ C
Sbjct: 1076 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGPCVGQ 1133
Query: 1022 PACGGNHQNSTVRADV 1037
ACG H T D+
Sbjct: 1134 GACGRQHLEPTGTIDM 1149
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 9/146 (6%)
Query: 859 WAP----CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 914
W P CS +CG G+ ++ C VQ LC +P R C PC P
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 954
Query: 915 VTEEWGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAG-DRPEARRPCLRVPCP 972
+ ACS SCG+ GV R + C + +++ C G RPE + C PCP
Sbjct: 955 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVC 998
+W++ + CSA+CG G +R V C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVAC 1039
Score = 52.4 bits (124), Expect = 3e-06
Identities = 69/305 (22%), Positives = 97/305 (31%), Gaps = 78/305 (25%)
Query: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR 901
+LE Y WA+ + PCS +CGGG++ C + + ++P
Sbjct: 738 VLEPCPPY-WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 796
Query: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
CN PC W E +C+ S G G+ C+ V ++
Sbjct: 797 ETCNPQPCPAR-WEVSEPSSCT-SAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 854
Query: 962 ARRPCLRVPCPAQW-------------------RLGA-----WS----QCSATCGEGIQQ 993
A PC+ + CP W R GA W+ CS +CG G+ +
Sbjct: 855 APEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME 914
Query: 994 RQVVCRTNA---------NSLGHCEGDRPDTVQVCSLPA------------CG------- 1025
+ +C +A L G R + Q PA CG
Sbjct: 915 LRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 974
Query: 1026 -------GNHQNSTVRADV--WELGTPEGQWVPQSEPLHPINKISSTEPC-------TGD 1069
G + D L PE Q EP P K+ S PC T
Sbjct: 975 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTAR 1034
Query: 1070 RSVFC 1074
RSV C
Sbjct: 1035 RSVAC 1039
Score = 41.6 bits (96), Expect = 0.005
Identities = 24/74 (32%), Positives = 31/74 (41%), Gaps = 8/74 (10%)
Query: 851 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
TY W + +W CS +CG GIQ + C + V C H +P + R C PC
Sbjct: 1073 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV-RGCWAGPCV 1131
Query: 911 QPVWVTEEWGACSR 924
GAC R
Sbjct: 1132 GQ-------GACGR 1138
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 330 bits (846), Expect = 5e-90
Identities = 245/811 (30%), Positives = 371/811 (45%), Gaps = 61/811 (7%)
Query: 249 RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
+++R A G +E+L+ V V + H +E + YVLT +NI E+ D SLG + L
Sbjct: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
Query: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF---- 364
V+++++ + I N + SL VC W+ + +D + H D V+++TR D
Sbjct: 129 VKMVILTEPEGAPNI-TANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 365 GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDG-QGNGCADETS 423
G ++G + G C P SC + + GF IAHE GH G+EHDG G+GC
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
Query: 424 LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPS--YDCLLDDPF---DPAWPQPPELPGIN 478
G VMA A WS CS+ +L L + C+ D P A P PG+
Sbjct: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLY 304
Query: 479 YSMDEQCRFDFGSGYQTC-LAFRTFEPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAPGK 536
YS +EQCR FG C A + C+ L C + P + C P LDGTEC K
Sbjct: 305 YSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEK 364
Query: 537 WCFKGHC---IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRL 593
WC KG C + +P G WSSW CSRSCGGGV +R R CNNP PA+GGR
Sbjct: 365 WCSKGRCRSLVELTP--IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRA 422
Query: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDA 646
C+G + ++CN++ C T +F +QQCA+ + + + + + W VP+ D
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD-- 480
Query: 647 QKCELICQSADTGDVVFMNQVVHDGTRCSYRDP-----YSVCARGECVPVGCDKEVGSMK 701
C +C++ ++ DGTRC P S+C G C GCD + S +
Sbjct: 481 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 540
Query: 702 ADDKCGVCGGDNSHCRTVKG--TLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVV 759
D+C VCGGDNS C KG T G+A + L + + ++ + HR +
Sbjct: 541 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP--------NLTSVYIANHRPLF 592
Query: 760 KN---QVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPP 816
+ ++ G +++ K + + T+ ++ ED + + +L T LP I P
Sbjct: 593 THLAVRIGGRYVVAGKMSISPNTTYPSL---LEDGRVEYRVAL-TEDRLPRLEEIRIWGP 648
Query: 817 TEGGPRSSLAYKYVIHEDLL--PLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 874
+ + +Y L P I + + WA PCS +CG G+++
Sbjct: 649 LQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVN 707
Query: 875 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTR 934
Y C + +V+ C ++P C PC P W ++G CS SCG G++ R
Sbjct: 708 YSCLDQARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSASCGG-GLRER 765
Query: 935 GIQCLLPLSNGTHKVMPAKACAGDRPE--ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQ 992
++C+ + + PA+ AG + A C PCPA+W + S C++ G G+
Sbjct: 766 PVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLA 825
Query: 993 QRQVVCRTNANSLGHCEGDRPDTVQVCSLPA 1023
C A+ L + P +V LPA
Sbjct: 826 LENETCVPGADGLEAPVTEGPGSVDE-KLPA 855
Score = 88.2 bits (217), Expect = 4e-17
Identities = 53/144 (36%), Positives = 69/144 (47%), Gaps = 9/144 (6%)
Query: 860 APCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKPIRRRCNQHPCSQPVWV 915
A CS +CG G+ C R + L C RP+P + C+ PC P W
Sbjct: 960 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWK 1017
Query: 916 TEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLRVPCPAQ 974
G CS SCG LG R + C+ L G + ACA RPEA PCL C +
Sbjct: 1018 VMSLGPCSASCG-LGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR 1075
Query: 975 WRLGAWSQCSATCGEGIQQRQVVC 998
W +G W +CS +CG+GIQ+R+ C
Sbjct: 1076 WHVGTWMECSVSCGDGIQRRRDTC 1099
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 9/146 (6%)
Query: 859 WAP----CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 914
W P CS +CG G+ ++ C VQ LC +P R C PC P
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 954
Query: 915 VTEEWGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAG-DRPEARRPCLRVPCP 972
+ ACS SCG+ GV R + C + +++ C G RPE + C PCP
Sbjct: 955 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVC 998
+W++ + CSA+CG G +R V C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVAC 1039
Score = 52.4 bits (124), Expect = 3e-06
Identities = 69/305 (22%), Positives = 97/305 (31%), Gaps = 78/305 (25%)
Query: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR 901
+LE Y WA+ + PCS +CGGG++ C + + ++P
Sbjct: 738 VLEPCPPY-WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 796
Query: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
CN PC W E +C+ S G G+ C+ V ++
Sbjct: 797 ETCNPQPCPAR-WEVSEPSSCT-SAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 854
Query: 962 ARRPCLRVPCPAQW-------------------RLGA-----WS----QCSATCGEGIQQ 993
A PC+ + CP W R GA W+ CS +CG G+ +
Sbjct: 855 APEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME 914
Query: 994 RQVVCRTNA---------NSLGHCEGDRPDTVQVCSLPA------------CG------- 1025
+ +C +A L G R + Q PA CG
Sbjct: 915 LRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 974
Query: 1026 -------GNHQNSTVRADV--WELGTPEGQWVPQSEPLHPINKISSTEPC-------TGD 1069
G + D L PE Q EP P K+ S PC T
Sbjct: 975 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTAR 1034
Query: 1070 RSVFC 1074
RSV C
Sbjct: 1035 RSVAC 1039
Score = 41.2 bits (95), Expect = 0.006
Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 1/59 (1%)
Query: 851 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
TY W + +W CS +CG GIQ + C + V C H +P + R C PC
Sbjct: 1073 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV-RGCWAGPC 1130
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 325 bits (833), Expect = 2e-88
Identities = 238/763 (31%), Positives = 346/763 (45%), Gaps = 54/763 (7%)
Query: 94 GTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECV 153
G++ PG L + FG+ L L L + + V G +V++ EL
Sbjct: 69 GSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGA-EPGTY 127
Query: 154 YTGGVTGMPGAAVAISNCDG--LAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREA 211
TG + G P +VA + DG L G+++ + ++PLE G H++ R+
Sbjct: 128 LTGTINGDP-ESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRK-- 184
Query: 212 VQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSV 271
+ A G G + N+ +G R +R A + +E L+V DD +
Sbjct: 185 -------------SPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRF-VETLVVADDKM 230
Query: 272 VRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRS 331
FHG ++ Y+LT+M + + S+ +++ + RL+++G + + + +++
Sbjct: 231 AAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGP-SAAQT 288
Query: 332 LEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF---GPSGMQGYAPVTGMCHPLRSCALN 388
L C W + S +H D + TRQD G A V +C P RSCA+
Sbjct: 289 LRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIV 348
Query: 389 HEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGS---VMAPLVQAAFHRFHWSRCS 445
+DG SAF AHE GHV M HD + L + VMAP++ WS CS
Sbjct: 349 EDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCS 408
Query: 446 KLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFE 503
++ +L + CLLD P P P PG +Y D QC+ FG + C
Sbjct: 409 ARFITDFLDNGYGHCLLDKPEAPLH-LPVTFPGKDYDADRQCQLTFGPDSRHCPQLPP-- 465
Query: 504 PCKQLWCS-HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG--QDGGWSS 560
PC LWCS H + C+TK P DGT C P + C G C+ Q + Q GGW
Sbjct: 466 PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGP 525
Query: 561 WTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP-GTYEDFRAQ 619
W +G CSR+CGGGV+ SR C P P GG+ C G ++ CN+E+CP G+ FR +
Sbjct: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREE 585
Query: 620 QCA---KRNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 675
QCA R + WVP Y +C+L CQ+ G + V DGT CS
Sbjct: 586 QCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCS 645
Query: 676 YRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKL 735
D SVC +G C+ GCD+ +GS K DKC VCGGD S C G+ K + G +
Sbjct: 646 -PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKF--RYGYNNV 702
Query: 736 VQIPAGARHIQIEALEKSPHRIV--VKNQVTGSFILNPKGKEATSRTFT----AMGLEWE 789
V IPAGA HI + HR + GS+ LN + S T A+ L +
Sbjct: 703 VTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS 762
Query: 790 DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSS-LAYKYVI 831
A A E+L GPL + + + L G P+ + L Y + +
Sbjct: 763 GATA-ASETLSGHGPLAQPLTLQVL--VAGNPQDTRLRYSFFV 802
Score = 35.0 bits (79), Expect = 0.44
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 18/83 (21%)
Query: 941 PLSNGTHKVMPAKACAGDRPEARRPCLR--------VPCPAQWR-LGAWSQCSATCGEGI 991
P ++GT PA+AC G R CL +P W G W CS TCG G+
Sbjct: 488 PWADGT-PCGPAQACMGGR------CLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV 540
Query: 992 Q--QRQVVCRTNANSLGHCEGDR 1012
Q R N +CEG R
Sbjct: 541 QFSSRDCTRPVPRNGGKYCEGRR 563
Score = 34.3 bits (77), Expect = 0.75
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 859 WAPCSKACGGGIQFTKYGCRR 879
W CS+ CGGG+QF+ C R
Sbjct: 529 WGDCSRTCGGGVQFSSRDCTR 549
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 313 bits (803), Expect = 5e-85
Identities = 237/806 (29%), Positives = 360/806 (44%), Gaps = 82/806 (10%)
Query: 249 RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
+++R A G +E+L+ V V + H +E + YVLT +NI E+ D SLG + L
Sbjct: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
Query: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF---- 364
V+++++ + I N + SL VC W+ + +D + H D V+++TR D
Sbjct: 129 VKMVILTEPEGAPNI-TANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 365 GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDG-QGNGCADETS 423
G ++G + G C P SC + + GF IAHE GH G+EHDG G+GC
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
Query: 424 LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDE 483
G VMA A WS CS+ +L L S +E
Sbjct: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SANE 278
Query: 484 QCRFDFGSGYQTC-LAFRTFEPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKG 541
QCR FG C A + C+ L C + P + C P LDGTEC KWC KG
Sbjct: 279 QCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKG 338
Query: 542 HC---IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPM 598
C + +P G WSSW CSRSCGGGV +R R CNNP PA+GGR C+G
Sbjct: 339 RCRSLVELTP--IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 396
Query: 599 FEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAQKCEL 651
+ ++CN++ C T +F +QQCA+ + + + + + W VP+ D C
Sbjct: 397 LQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD--ALCRH 454
Query: 652 ICQSADTGDVVFMNQVVHDGTRCSYRDP-----YSVCARGECVPVGCDKEVGSMKADDKC 706
+C++ ++ DGTRC P S+C G C GCD + S + D+C
Sbjct: 455 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 514
Query: 707 GVCGGDNSHCRTVKG--TLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKN--- 761
VCGGDNS C KG T G+A + L + + ++ + HR + +
Sbjct: 515 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP--------NLTSVYIANHRPLFTHLAV 566
Query: 762 QVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGP 821
++ G +++ K + + T+ ++ ED + + +L T LP I P +
Sbjct: 567 RIGGRYVVAGKMSISPNTTYPSL---LEDGRVEYRVAL-TEDRLPRLEEIRIWGPLQEDA 622
Query: 822 RSSLAYKYVIHEDLL--PLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRR 879
+ +Y L P I + + WA PCS +CG G+++ Y C
Sbjct: 623 DIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLD 681
Query: 880 RRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCL 939
+ +V+ C ++P C PC P W ++G CS SCG G++ R ++C+
Sbjct: 682 QARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSASCGG-GLRERPVRCV 739
Query: 940 LPLSNGTHKVMPAKACAGDRPE--ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVV 997
+ + PA+ AG + A C PCPA+W + S C++ G G+
Sbjct: 740 EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENET 799
Query: 998 CRTNANSLGHCEGDRPDTVQVCSLPA 1023
C A+ L + P +V LPA
Sbjct: 800 CVPGADGLEAPVTEGPGSVDE-KLPA 824
Score = 88.6 bits (218), Expect = 3e-17
Identities = 65/196 (33%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 860 APCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKPIRRRCNQHPCSQPVWV 915
A CS +CG G+ C R + L C RP+P + C+ PC P W
Sbjct: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWK 986
Query: 916 TEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLRVPCPAQ 974
G CS SCG LG R + C+ L G + ACA RPEA PCL C +
Sbjct: 987 VMSLGPCSASCG-LGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR 1044
Query: 975 WRLGAWSQCSATCGEGIQQRQVVC-------RTNANSLGHCEGDRPDTVQVC------SL 1021
W +G W +CS +CG+GIQ+R+ C A+ H +P TV+ C
Sbjct: 1045 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGPCVGQ 1102
Query: 1022 PACGGNHQNSTVRADV 1037
ACG H T D+
Sbjct: 1103 GACGRQHLEPTGTIDM 1118
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 9/146 (6%)
Query: 859 WAP----CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 914
W P CS +CG G+ ++ C VQ LC +P R C PC P
Sbjct: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 923
Query: 915 VTEEWGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAG-DRPEARRPCLRVPCP 972
+ ACS SCG+ GV R + C + +++ C G RPE + C PCP
Sbjct: 924 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
Query: 973 AQWRLGAWSQCSATCGEGIQQRQVVC 998
+W++ + CSA+CG G +R V C
Sbjct: 983 PRWKVMSLGPCSASCGLGTARRSVAC 1008
Score = 52.4 bits (124), Expect = 3e-06
Identities = 69/305 (22%), Positives = 97/305 (31%), Gaps = 78/305 (25%)
Query: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR 901
+LE Y WA+ + PCS +CGGG++ C + + ++P
Sbjct: 707 VLEPCPPY-WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 765
Query: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
CN PC W E +C+ S G G+ C+ V ++
Sbjct: 766 ETCNPQPCPAR-WEVSEPSSCT-SAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 823
Query: 962 ARRPCLRVPCPAQW-------------------RLGA-----WS----QCSATCGEGIQQ 993
A PC+ + CP W R GA W+ CS +CG G+ +
Sbjct: 824 APEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME 883
Query: 994 RQVVCRTNA---------NSLGHCEGDRPDTVQVCSLPA------------CG------- 1025
+ +C +A L G R + Q PA CG
Sbjct: 884 LRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 943
Query: 1026 -------GNHQNSTVRADV--WELGTPEGQWVPQSEPLHPINKISSTEPC-------TGD 1069
G + D L PE Q EP P K+ S PC T
Sbjct: 944 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTAR 1003
Query: 1070 RSVFC 1074
RSV C
Sbjct: 1004 RSVAC 1008
Score = 41.6 bits (96), Expect = 0.005
Identities = 24/74 (32%), Positives = 31/74 (41%), Gaps = 8/74 (10%)
Query: 851 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
TY W + +W CS +CG GIQ + C + V C H +P + R C PC
Sbjct: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV-RGCWAGPCV 1100
Query: 911 QPVWVTEEWGACSR 924
GAC R
Sbjct: 1101 GQ-------GACGR 1107
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 215 bits (547), Expect = 2e-55
Identities = 156/501 (31%), Positives = 211/501 (42%), Gaps = 72/501 (14%)
Query: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Q W W+++ CSR+CGGGV R R C + GG C+GP ++ C +E CP
Sbjct: 25 QSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGA 83
Query: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
DFRA+QCA+ + Q ++ W+PY + KCEL C + V DGT
Sbjct: 84 RDFRAEQCAEFDGAEF-QGRRYRWLPYYSAPN--KCELNCIPKGENFYYKHREAVVDGTP 140
Query: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
C VC G C VGCD E+ S K +DKC CGGD + C V GT A+ + A+
Sbjct: 141 CE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF-DANDLSRAV 198
Query: 734 KLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMG--LEWEDA 791
K V G + LN +R A L +E
Sbjct: 199 K---------------------------NVRGEYYLNGHWTIEAARALPAASTILHYERG 231
Query: 792 VED--AKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEM 849
E A E L GP E + I + P + Y+Y + L
Sbjct: 232 AEGDLAPERLHARGPTSEPLVIELISQE---PNPGVHYEYHL------------PLRRPS 276
Query: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
+ W+ SW+ CS CGGG Q C DH H+C + RP RR CN HPC
Sbjct: 277 PGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRPAD-RRSCNLHPC 333
Query: 910 SQPV-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG--DRPEARRPC 966
+ W W CS SCG G Q+R + C+ G + + CAG +P A + C
Sbjct: 334 PETKRWKAGPWAPCSASCGG-GSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQAC 392
Query: 967 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG----DRPDTVQVCSLP 1022
C A W W +CS +CG G+++R V CR SL H DRP + C
Sbjct: 393 NLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV-- 449
Query: 1023 ACGGNHQNSTVRAD-VWELGT 1042
H++ + +D W +GT
Sbjct: 450 -----HEDCPLLSDQAWHVGT 465
Score = 40.0 bits (92), Expect = 0.014
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 9/90 (10%)
Query: 555 DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYE 614
D W T +G CS+SC G R R C P++ G L + + CN++ C E
Sbjct: 458 DQAWHVGT-WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQE 516
Query: 615 DFRAQQCAKRNSYYVHQNAKHSWVPYEPDD 644
Q VH A + W+P P +
Sbjct: 517 VPSMQD--------VHTPASNPWMPLGPQE 538
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 213 bits (541), Expect = 1e-54
Identities = 145/499 (29%), Positives = 220/499 (44%), Gaps = 71/499 (14%)
Query: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
+DG W +W + CSR+CGGG R C + C G Y+ C++ +CP
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEA 85
Query: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
DFRAQQC+ N H + W+P D D C L CQ+ T VV + V DGTR
Sbjct: 86 GDFRAQQCSAHNDVK-HHGQFYEWLPVSNDPD-NPCSLKCQAKGTTLVVELAPKVLDGTR 143
Query: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
C Y + +C G C VGCD ++GS +D CGVC GD S CR V+ G+ Q A
Sbjct: 144 C-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVR---GQYKSQLSAT 199
Query: 734 K----LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAM----G 785
K +V IP G+RHI++ + K P + ++ + + KG+ + S T T +
Sbjct: 200 KSDDTVVAIPYGSRHIRL--VLKGPDHLYLETKT----LQGTKGENSLSSTGTFLVDNSS 253
Query: 786 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 845
++++ + KE L+ +GPL + + +++ ++ ++
Sbjct: 254 VDFQKFPD--KEILRMAGPLTADFIV----KIRNSGSADSTVQFIFYQPII--------- 298
Query: 846 LEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRR 902
+ W + PCS CGGG Q T C R + +V C + +PKP +
Sbjct: 299 ------HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQ 352
Query: 903 RCNQHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCL-LPLSNG 945
CN PC P W W ACS SCG G+Q+R + C+ +
Sbjct: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGH 411
Query: 946 THKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC--RTNAN 1003
V K + +PC CP +W WS C+ TCG+G++ R V+C +
Sbjct: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
Query: 1004 SLGHCEGDRPDTVQVCSLP 1022
+ G +P + C +P
Sbjct: 471 TGGCSPKTKPHIKEECIVP 489
Score = 114 bits (284), Expect = 7e-25
Identities = 56/177 (31%), Positives = 88/177 (49%), Gaps = 6/177 (3%)
Query: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
+ Y+W + + CS++CGGG+Q C ++ + +LC +RP + + CN PC
Sbjct: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
Query: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHK--VMPAKACAGDRPEARRPCL 967
W +W CS +CG +G+QTR + C LS ++ ++ + C +P + C
Sbjct: 667 PAR-WEIGKWSPCSLTCG-VGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN 724
Query: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPAC 1024
R CP W W CS TCG G+Q+R+V+C+ E P+T S PAC
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE--LPETFCSASKPAC 779
Score = 110 bits (275), Expect = 8e-24
Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 11/152 (7%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGC-----RRRRDHHMVQRHLCDHKKRPKPIR-RRCNQH 907
W + W+PCS CG G+Q C R + ++ LC ++PKP + CN+
Sbjct: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELC---RQPKPSTVQACNRF 726
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
C P W +W CSR+CG GVQ R + C +++G+ +P C+ +P ++ C
Sbjct: 727 NCP-PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
Query: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR 999
+ CP++W L W++CS +CGEG Q R +CR
Sbjct: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
Score = 92.4 bits (228), Expect = 2e-18
Identities = 58/193 (30%), Positives = 87/193 (45%), Gaps = 18/193 (9%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHM---VQRHLCDHKKRPKPIRRRCNQHPCS 910
W + SW+ C+++CGGG+Q + C++ + + V +C + + CNQ C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 911 QPVWVTEEWGACSRSC--GKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCL 967
+ W WG C+ C L VQ R + C +P++ C+ RP + + C
Sbjct: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFC----QTRDGITLPSEQCSALPRPVSTQNCW 1662
Query: 968 RVPCPAQWRLGAWSQCSATCGE-GIQQRQVVC---RTNANSLGH-CE-GDRPDTVQVCSL 1021
C WR+ W+ C+ATCG G Q R+V C RTN H C G RP Q C++
Sbjct: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
Query: 1022 PACGGNHQNSTVR 1034
C T R
Sbjct: 1723 TPCENMECRDTTR 1735
Score = 80.5 bits (197), Expect = 9e-15
Identities = 60/204 (29%), Positives = 80/204 (39%), Gaps = 40/204 (19%)
Query: 857 KSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHL-CDHKKRPKPIRRR-CNQHPCSQPV- 913
++W+ C+ CG G Q C+ L D + PKP +R C PCS +
Sbjct: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
Query: 914 ----------------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMP 951
W E + CS SCG GVQ + CL + T +
Sbjct: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCL---NKQTREPAE 644
Query: 952 AKACAGDR--PEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC---------RT 1000
C R P+ + C PCPA+W +G WS CS TCG G+Q R V C T
Sbjct: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
Query: 1001 NANSLGHCEGDRPDTVQVCSLPAC 1024
+ C +P TVQ C+ C
Sbjct: 705 VILADELCRQPKPSTVQACNRFNC 728
Score = 77.0 bits (188), Expect = 1e-13
Identities = 70/278 (25%), Positives = 102/278 (36%), Gaps = 36/278 (12%)
Query: 852 YEWALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
Y W++ A CS +CG G+Q + C V C K RP CN+ C
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 911 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC--AGDRPEARRPCLR 968
W+ W AC+RSCG GVQTR + C ++G + C RP + C +
Sbjct: 1547 SR-WMVTSWSACTRSCGG-GVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
Query: 969 VPCPAQWRLGAWSQCSATC---GEGIQQRQVVCRTNANSLGHCEG----DRPDTVQVCSL 1021
C +W +W QC+ C +Q RQV C+T E RP + Q C
Sbjct: 1605 QLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
Query: 1022 PACG---------------GNHQNSTVRADVWELGTPEG------QWVPQSEPLHPINKI 1060
AC GN+ + R + T + W P+ N
Sbjct: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
Query: 1061 SSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIK 1098
D + +C+ + C + + CC +C K
Sbjct: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Score = 69.7 bits (169), Expect = 2e-11
Identities = 60/263 (22%), Positives = 97/263 (36%), Gaps = 80/263 (30%)
Query: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCN-QHP 908
D +W + W+PC+ CG G+++ C DH + C K +P I+ C P
Sbjct: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCSPKTKPH-IKEECIVPTP 491
Query: 909 C-----------------------------SQPVWVTEEWGACSRSCGKLGVQTRGIQCL 939
C +P ++ E W AC+ +CG +G Q R ++C
Sbjct: 492 CYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRCQ 550
Query: 940 LPLS-NGTHKVMPAKACAGDRPEARRPCLRVPCPAQ------------------------ 974
+ LS + + +P C G +P ++R C PC +
Sbjct: 551 VLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYD 610
Query: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNAN----SLGHCEGDR--PDTVQVCSLPACGGNH 1028
W +++CS +CG G+Q+ V C C R P ++ C+L C
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPAR- 669
Query: 1029 QNSTVRADVWELGTPEGQWVPQS 1051
WE+ G+W P S
Sbjct: 670 ---------WEI----GKWSPCS 679
Score = 40.8 bits (94), Expect = 0.008
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 19/113 (16%)
Query: 528 DGTECAPGKWCFKGHCIWKSPE----QTYGQDGGWSSWTK--------FGSCSRSCGGGV 575
+G + A + C+ G C + PE +T G GG + + F CS SCGGGV
Sbjct: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
Query: 576 RSRSRSCNNP---SPAYGGRLCL---GPMFEYQVCNSEECPGTYEDFRAQQCA 622
+ SC N PA LC+ P + CN + CP +E + C+
Sbjct: 628 QEAVVSCLNKQTREPA-EENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCS 679
Score = 39.7 bits (91), Expect = 0.018
Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 2/75 (2%)
Query: 836 LPLIGSNNVLLEEMDTYEWALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHK 894
LP S E + W + W C+ CG G Q + C R + V HLC
Sbjct: 1652 LPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
Query: 895 KRPKPIRRRCNQHPC 909
RP +RCN PC
Sbjct: 1712 PRPAN-WQRCNITPC 1725
Score = 37.0 bits (84), Expect = 0.12
Identities = 53/227 (23%), Positives = 77/227 (33%), Gaps = 56/227 (24%)
Query: 473 ELPGINYSMDEQCRFDFGSGYQ----TCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLD 528
EL Y +C G G Q +CL +T EP ++ C T + PP
Sbjct: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEE---------NLCVTSRRPPQL 657
Query: 529 GTEC----APGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCN- 583
C P +W + G WS CS +CG G+++R C+
Sbjct: 658 LKSCNLDPCPARW----------------EIGKWSP------CSLTCGVGLQTRDVFCSH 695
Query: 584 ------NPSPAYGGRLCLGPM-FEYQVCNSEECPGTYEDFRAQQCA--------KRNSYY 628
N + LC P Q CN CP + + Q C+ KR
Sbjct: 696 LLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
Query: 629 VHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 675
+ A S++ P+ + CQ A D ++ D T CS
Sbjct: 756 KQRMADGSFLEL-PETFCSASKPACQQACKKDDCPSEWLLSDWTECS 801
Score = 33.5 bits (75), Expect = 1.3
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 4/105 (3%)
Query: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIRRRCNQHPC 909
EW L W CS +CG G Q CR+ +V LC I R C C
Sbjct: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI-RPCMLATC 849
Query: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKA 954
++P + + + K+ +QTR + L + G ++P A
Sbjct: 850 ARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTA 894
Score = 32.0 bits (71), Expect = 3.7
Identities = 13/26 (50%), Positives = 19/26 (73%), Gaps = 2/26 (7%)
Query: 559 SSW--TKFGSCSRSCGGGVRSRSRSC 582
S W T + +C+RSCGGGV++R +C
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTC 1572
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 213 bits (541), Expect = 1e-54
Identities = 145/499 (29%), Positives = 220/499 (44%), Gaps = 71/499 (14%)
Query: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
+DG W +W + CSR+CGGG R C + C G Y+ C++ +CP
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEA 85
Query: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
DFRAQQC+ N H + W+P D D C L CQ+ T VV + V DGTR
Sbjct: 86 GDFRAQQCSAHNDVK-HHGQFYEWLPVSNDPD-NPCSLKCQAKGTTLVVELAPKVLDGTR 143
Query: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
C Y + +C G C VGCD ++GS +D CGVC GD S CR V+ G+ Q A
Sbjct: 144 C-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVR---GQYKSQLSAT 199
Query: 734 K----LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAM----G 785
K +V IP G+RHI++ + K P + ++ + + KG+ + S T T +
Sbjct: 200 KSDDTVVAIPYGSRHIRL--VLKGPDHLYLETKT----LQGTKGENSLSSTGTFLVDNSS 253
Query: 786 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 845
++++ + KE L+ +GPL + + +++ ++ ++
Sbjct: 254 VDFQKFPD--KEILRMAGPLTADFIV----KIRNSGSADSTVQFIFYQPII--------- 298
Query: 846 LEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRR 902
+ W + PCS CGGG Q T C R + +V C + +PKP +
Sbjct: 299 ------HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQ 352
Query: 903 RCNQHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCL-LPLSNG 945
CN PC P W W ACS SCG G+Q+R + C+ +
Sbjct: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGH 411
Query: 946 THKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC--RTNAN 1003
V K + +PC CP +W WS C+ TCG+G++ R V+C +
Sbjct: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
Query: 1004 SLGHCEGDRPDTVQVCSLP 1022
+ G +P + C +P
Sbjct: 471 TGGCSPKTKPHIKEECIVP 489
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 208 bits (529), Expect = 3e-53
Identities = 153/542 (28%), Positives = 235/542 (43%), Gaps = 79/542 (14%)
Query: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
+DG W +W + CSR+CGGG R C GR C G Y+ C++ +CP
Sbjct: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA 127
Query: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
EDFRAQQC+ N +Q + W+P +D A C L C + VV + V DGTR
Sbjct: 128 EDFRAQQCSAYNDVQ-YQGHYYEWLP-RYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
Query: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKG-TLGKASKQAGA 732
C+ D +C G C VGCD+++GS +D CGVC GD S CR V+G + S +
Sbjct: 186 CN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKRE 244
Query: 733 LKLVQIPAGARHIQIEALEKSPHRIVVKNQV----TGSFILNPKGKEATSRTFTAMGLEW 788
++ +P G+R ++I K P + ++++ G N G T +E+
Sbjct: 245 ENVIAVPLGSRSVRITV--KGPAHLFIESKTLQGSKGEHSFNSPGVFLVENT----TVEF 298
Query: 789 EDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEE 848
+ E +++ K GPL +A + S+ ++ ++ +
Sbjct: 299 QRGSE--RQTFKIPGPL---MADFIFKTRYTAAKDSVV-QFFFYQPI------------- 339
Query: 849 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRRRCN 905
+++W + PC+ CGGG Q C R +V H C + +PKP + C+
Sbjct: 340 --SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECS 397
Query: 906 QHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNG-THK 948
PC P W W ACS SCG G+Q R C+ +G +
Sbjct: 398 MDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGG-GIQRRSFVCVEESMHGEILQ 456
Query: 949 VMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC 1008
V K +P+ + C CP +W WSQC+ TCG G++ R V+C + H
Sbjct: 457 VEEWKCMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRGE--HV 513
Query: 1009 EGDRPD----TVQVCSLP-ACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISST 1063
G P + C +P C + S V A + W+ Q++ L +I++
Sbjct: 514 GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL--------PWLKQAQELEE-TRIATE 564
Query: 1064 EP 1065
EP
Sbjct: 565 EP 566
Score = 118 bits (296), Expect = 3e-26
Identities = 62/181 (34%), Positives = 86/181 (47%), Gaps = 13/181 (7%)
Query: 851 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
TY+W + PC+ C GG Q C + V LCD RP + + CN PC
Sbjct: 645 TYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPC- 703
Query: 911 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVP 970
P W WG CS +CG +G+QTR + CL P P + C ++P A + C +
Sbjct: 704 PPRWHVGSWGPCSATCG-VGIQTRDVYCLHP----GETPAPPEECRDEKPHALQACNQFD 758
Query: 971 CPAQWRLGAWSQCSATCGEGIQQRQVVCR---TNANSLG----HCEGDRPDTVQVCSLPA 1023
CP W + W QCS TCG G Q R+V CR T+ + L C+G + + + C+
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTD 818
Query: 1024 C 1024
C
Sbjct: 819 C 819
Score = 103 bits (256), Expect = 1e-21
Identities = 53/146 (36%), Positives = 72/146 (49%), Gaps = 5/146 (3%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
W + SW PCS CG GIQ C + D K + CNQ C P
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHAL---QACNQFDCP-PG 762
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
W EEW CSR+CG G Q R + C L++G+ + + C G + + + C R CP
Sbjct: 763 WHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCR 999
+G WS+CS +CG GIQ+R+ VC+
Sbjct: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQ 847
Score = 92.0 bits (227), Expect = 3e-18
Identities = 78/269 (28%), Positives = 111/269 (41%), Gaps = 34/269 (12%)
Query: 854 WALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
W +W+ CS CG G + + C V LCDH ++P CN C
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQE-VSEALCDHLQKPLAGFEPCNIRDCPAR 1486
Query: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLRVPC 971
W T W CS SCG+ G +R + C +NGT +V+ +ACA DRP R+PC PC
Sbjct: 1487 -WFTSVWSQCSVSCGE-GYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 972 PAQWRLGAWSQCSATC-GEGI--QQRQVVCRTNANSLGHCEGDRPDTVQVCS-------- 1020
QW G ++C C G + QQR C+ N++ + RP + C+
Sbjct: 1545 -VQWEPG--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCW 1601
Query: 1021 --------LPACGGNHQNSTVRADVWELGTPEGQ--WVPQSEPL---HPINKISSTEPCT 1067
ACG Q+ V P + V + +P+ H + S CT
Sbjct: 1602 HTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP-SCDRDCT 1660
Query: 1068 GDRSVFCQMEVLDRYCSIPGYHRLCCVSC 1096
D + +C CS+ Y + CC SC
Sbjct: 1661 -DTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
Score = 77.4 bits (189), Expect = 8e-14
Identities = 48/119 (40%), Positives = 59/119 (49%), Gaps = 15/119 (12%)
Query: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEAR-RPC 966
P +P W W CS +CG LG + + QC++ +NG +V A +P A PC
Sbjct: 1422 PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVM--ANG-QEVSEALCDHLQKPLAGFEPC 1478
Query: 967 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC-RTNANSLGHCEGDRPDTVQVCSLPAC 1024
CPA+W WSQCS +CGEG RQV C RT AN TVQV S AC
Sbjct: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANG----------TVQVVSPRAC 1527
Score = 72.0 bits (175), Expect = 3e-12
Identities = 63/249 (25%), Positives = 95/249 (38%), Gaps = 48/249 (19%)
Query: 859 WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKP---IRRRCNQHPCSQ 911
W+ CS CG G+Q + CR + L C+ K P + C++ P S+
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
Query: 912 PV-------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC--A 956
+ W + C+ +C +G I L + T + + C
Sbjct: 633 ELDIPLPEDSETTYDWEYAGFTPCTATC--VGGHQEAIAVCLHIQ--TQQTVNDSLCDMV 688
Query: 957 GDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLG---HCEGDRP 1013
P + C PCP +W +G+W CSATCG GIQ R V C + C ++P
Sbjct: 689 HRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKP 748
Query: 1014 DTVQVCS----------------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPI 1057
+Q C+ CGG QN R +L T +G ++ S+ L
Sbjct: 749 HALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNR--RVTCRQLLT-DGSFLNLSDELCQG 805
Query: 1058 NKISSTEPC 1066
K SS + C
Sbjct: 806 PKASSHKSC 814
Score = 70.9 bits (172), Expect = 7e-12
Identities = 68/304 (22%), Positives = 110/304 (36%), Gaps = 81/304 (26%)
Query: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHM------VQRHL---------CDHK 894
D +W W+ C+ CG G+++ C R H+ ++ H+ C
Sbjct: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
Query: 895 KRPKPIRRRC-----------NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLS 943
K P+ + + +P ++ E W ACS +CG GVQ R ++C + L+
Sbjct: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLT 596
Query: 944 -NGTHKVMPAKACAGDRPEARRPCLRVPC---PA----------------QWRLGAWSQC 983
T +P + C G + RPCL C PA W ++ C
Sbjct: 597 FTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
Query: 984 SATCGEGIQQRQVVC------RTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTVRADV 1037
+ATC G Q+ VC +T +SL P Q C+ C
Sbjct: 657 TATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPR---------- 706
Query: 1038 WELGTPEGQWVPQSEP------------LHPINKISSTEPCTGDRSVFCQMEVLDRYCSI 1085
W +G+ W P S LHP + E C ++ ++ +++
Sbjct: 707 WHVGS----WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKP--HALQACNQFDCP 760
Query: 1086 PGYH 1089
PG+H
Sbjct: 761 PGWH 764
Score = 34.7 bits (78), Expect = 0.57
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 2/62 (3%)
Query: 564 FGSCSRSCGGGVRSRSRSCNNP--SPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQC 621
+G CS +CG G+++R C +P +PA Q CN +CP + QQC
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQC 771
Query: 622 AK 623
++
Sbjct: 772 SR 773
Score = 32.0 bits (71), Expect = 3.7
Identities = 34/139 (24%), Positives = 49/139 (35%), Gaps = 46/139 (33%)
Query: 485 CRFDFGSGYQTCLAFRTFEPCKQLWCSHPDN----PYFCKTKKGPPLDGT---ECAPGKW 537
C G G QT + ++C HP P C+ +K L +C PG
Sbjct: 715 CSATCGVGIQT----------RDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPG-- 762
Query: 538 CFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSC-----NNPSPAYGGR 592
W E W + CSR+CGGG ++R +C +
Sbjct: 763 -------WHIEE-----------WQQ---CSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 801
Query: 593 LCLGP-MFEYQVCNSEECP 610
LC GP ++ C +CP
Sbjct: 802 LCQGPKASSHKSCARTDCP 820
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 169 bits (429), Expect = 1e-41
Identities = 132/486 (27%), Positives = 188/486 (38%), Gaps = 63/486 (12%)
Query: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELIC 653
C G + + C+ CP D RA QCA NS + W P+ +Q+CEL C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF-MGQLYQWEPFTEVQGSQRCELNC 422
Query: 654 QSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDN 713
+ V + V DGT C P +C G C+ GCD +GS + D CGVCGGD+
Sbjct: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 714 SHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQ-----VTGSFI 768
S CR V G L G K++ IPAGA +QI L S + + ++ + G++
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
Query: 769 LNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILAL-------------- 814
++P G T + E ESL GP + + + +
Sbjct: 542 VDPPGSYRAGGTVFRYNRPPRE--EGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVI 599
Query: 815 ---------------------------PPTEGGPRSSLAYKYVIHEDLLPLIGSN---NV 844
PP PR + + + +P + +
Sbjct: 600 SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
Query: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 904
L Y W + CS +CG G+ + C R + C RP C
Sbjct: 660 PLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
Query: 905 NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARR 964
+ PC P W EW +CSRSCG G Q R +QC G V P + RP +
Sbjct: 719 HGTPCP-PYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
Query: 965 PCLRVPCPAQWRLGA-WSQCSATCGEGIQQRQVVC-RTNANSLGHCE----GDRPDTVQV 1018
C C W +G+ WSQCS CG G + RQV C N + + E +P + +
Sbjct: 777 SCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREA 835
Query: 1019 CSLPAC 1024
C + C
Sbjct: 836 CDMGPC 841
Score = 98.2 bits (243), Expect = 4e-20
Identities = 79/280 (28%), Positives = 111/280 (39%), Gaps = 40/280 (14%)
Query: 854 WALKS-WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
W + S W+ CS CG G + + C + ++ +P P R C+ PC+
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQP-PSREACDMGPCTT- 843
Query: 913 VWVTEEWGA-CSRSCGKLGVQTRGIQCL-----LPLSNGTHKVMPAKAC-AGDRPEARRP 965
W +W + CS CG G+Q R + CL L G ++C G RP R
Sbjct: 844 AWFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
Query: 966 CLRVPCPAQWR--LGAWSQCSATCGEGIQQRQVVCRT------NANSLGHCEG-DRPDTV 1016
C PC WR G W +CS+ CG G Q+R ++C + N S +C RP +
Sbjct: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
Query: 1017 QVCSLPAC------------GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKIS-ST 1063
Q C AC + Q T +V L T + L P K ++
Sbjct: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNS 1022
Query: 1064 EPCTG-------DRSVFCQMEVLDRYCSIPGYHRLCCVSC 1096
+PC+ D S C + V R C P Y CC SC
Sbjct: 1023 QPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%)
Query: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 597
GH + E+ G +G W W ++ SCS+ CG GV+ RSR+C P+ L L P
Sbjct: 30 GHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP 86
Score = 36.2 bits (82), Expect = 0.20
Identities = 83/344 (24%), Positives = 116/344 (33%), Gaps = 84/344 (24%)
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
WV +W +CS+ CG +GVQ R C LP H +P PEA P + P P
Sbjct: 50 WV--QWASCSQPCG-VGVQRRSRTCQLPTVQ-LHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1033
+ + G G R A+ LG R +T ++ A + +
Sbjct: 106 TSPETLPLYRTQSRGRG-----GPLRGPASHLG-----REETQEI---RAARRSRLRDPI 152
Query: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1093
+ ++ G VP + PLH R+ P L
Sbjct: 153 KPGMFGYGR-----VPFALPLHRNR----------------------RHPRSPPRSELSL 185
Query: 1094 VSCIKKASGPNPGPDPGP--------TSLPP----FSTPGSPLPGPQDPADA---AEPPG 1138
+S + + P+P P P T LPP TP SP P P A P
Sbjct: 186 ISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTP-SPQAEPLSPETAQTEVAPRT 244
Query: 1139 KPTGSEDHQHGRA--TQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQ 1196
+P H +A T+ P + G +P+ P + SP G P
Sbjct: 245 RPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRP----- 299
Query: 1197 TPTP-VPEDKGQPGE----------------DLRHPGTSLPAAS 1223
P P VP +GQ G+ D +HPG LP S
Sbjct: 300 DPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLS 343
Score = 33.9 bits (76), Expect = 0.98
Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 38/201 (18%)
Query: 1043 PEGQWVPQSEPLHPINKISSTEPC---TGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKK 1099
PEG W P + S ++PC RS CQ+ + + S+P R
Sbjct: 43 PEGVWGPW------VQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALL 96
Query: 1100 ASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALD 1159
G P P P +LP + T GP P G E+ Q RA + D
Sbjct: 97 PRGQGPRPQTSPETLPLYRTQSRGRGGP------LRGPASHLGREETQEIRAARRSRLRD 150
Query: 1160 TSSPGT----QHPFA---------PETPIPGASWSISPTTPGGLPWGWTQTPTPVPED-- 1204
PG + PFA P +P IS +P +PTP E
Sbjct: 151 PIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIP-----SPTPRAEPFS 205
Query: 1205 -KGQPGEDLRHPGTSLPAASP 1224
G P +L P T L +P
Sbjct: 206 ANGSPQTEL--PPTELSVHTP 224
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 169 bits (429), Expect = 1e-41
Identities = 132/486 (27%), Positives = 188/486 (38%), Gaps = 63/486 (12%)
Query: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELIC 653
C G + + C+ CP D RA QCA NS + W P+ +Q+CEL C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF-MGQLYQWEPFTEVQGSQRCELNC 422
Query: 654 QSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDN 713
+ V + V DGT C P +C G C+ GCD +GS + D CGVCGGD+
Sbjct: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 714 SHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQ-----VTGSFI 768
S CR V G L G K++ IPAGA +QI L S + + ++ + G++
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
Query: 769 LNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILAL-------------- 814
++P G T + E ESL GP + + + +
Sbjct: 542 VDPPGSYRAGGTVFRYNRPPRE--EGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVI 599
Query: 815 ---------------------------PPTEGGPRSSLAYKYVIHEDLLPLIGSN---NV 844
PP PR + + + +P + +
Sbjct: 600 SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
Query: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 904
L Y W + CS +CG G+ + C R + C RP C
Sbjct: 660 PLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
Query: 905 NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARR 964
+ PC P W EW +CSRSCG G Q R +QC G V P + RP +
Sbjct: 719 HGTPCP-PYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
Query: 965 PCLRVPCPAQWRLGA-WSQCSATCGEGIQQRQVVC-RTNANSLGHCE----GDRPDTVQV 1018
C C W +G+ WSQCS CG G + RQV C N + + E +P + +
Sbjct: 777 SCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREA 835
Query: 1019 CSLPAC 1024
C + C
Sbjct: 836 CDMGPC 841
Score = 58.5 bits (140), Expect = 4e-08
Identities = 39/132 (29%), Positives = 55/132 (41%), Gaps = 11/132 (8%)
Query: 854 WALKSWAPCSKACGGGIQFTKYGCRRR--RDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
W W CS++CG G Q + CR+ V C H RP I + C C
Sbjct: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGH 785
Query: 912 PVW-VTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD-RPEARRPCLRV 969
W V W CS CG+ G ++R ++C+ N +V + +G +P +R C
Sbjct: 786 --WEVGSPWSQCSVRCGR-GQRSRQVRCV---GNNGDEVSEQECASGPPQPPSREACDMG 839
Query: 970 PCPAQWRLGAWS 981
PC W WS
Sbjct: 840 PCTTAWFHSDWS 851
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%)
Query: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 597
GH + E+ G +G W W ++ SCS+ CG GV+ RSR+C P+ L L P
Sbjct: 30 GHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP 86
Score = 36.2 bits (82), Expect = 0.20
Identities = 83/344 (24%), Positives = 116/344 (33%), Gaps = 84/344 (24%)
Query: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
WV +W +CS+ CG +GVQ R C LP H +P PEA P + P P
Sbjct: 50 WV--QWASCSQPCG-VGVQRRSRTCQLPTVQ-LHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
Query: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1033
+ + G G R A+ LG R +T ++ A + +
Sbjct: 106 TSPETLPLYRTQSRGRG-----GPLRGPASHLG-----REETQEI---RAARRSRLRDPI 152
Query: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1093
+ ++ G VP + PLH R+ P L
Sbjct: 153 KPGMFGYGR-----VPFALPLHRNR----------------------RHPRSPPRSELSL 185
Query: 1094 VSCIKKASGPNPGPDPGP--------TSLPP----FSTPGSPLPGPQDPADA---AEPPG 1138
+S + + P+P P P T LPP TP SP P P A P
Sbjct: 186 ISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTP-SPQAEPLSPETAQTEVAPRT 244
Query: 1139 KPTGSEDHQHGRA--TQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQ 1196
+P H +A T+ P + G +P+ P + SP G P
Sbjct: 245 RPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRP----- 299
Query: 1197 TPTP-VPEDKGQPGE----------------DLRHPGTSLPAAS 1223
P P VP +GQ G+ D +HPG LP S
Sbjct: 300 DPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLS 343
Score = 33.9 bits (76), Expect = 0.98
Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 38/201 (18%)
Query: 1043 PEGQWVPQSEPLHPINKISSTEPC---TGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKK 1099
PEG W P + S ++PC RS CQ+ + + S+P R
Sbjct: 43 PEGVWGPW------VQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALL 96
Query: 1100 ASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALD 1159
G P P P +LP + T GP P G E+ Q RA + D
Sbjct: 97 PRGQGPRPQTSPETLPLYRTQSRGRGGP------LRGPASHLGREETQEIRAARRSRLRD 150
Query: 1160 TSSPGT----QHPFA---------PETPIPGASWSISPTTPGGLPWGWTQTPTPVPED-- 1204
PG + PFA P +P IS +P +PTP E
Sbjct: 151 PIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIP-----SPTPRAEPFS 205
Query: 1205 -KGQPGEDLRHPGTSLPAASP 1224
G P +L P T L +P
Sbjct: 206 ANGSPQTEL--PPTELSVHTP 224
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 166 bits (421), Expect = 1e-40
Identities = 145/489 (29%), Positives = 214/489 (43%), Gaps = 50/489 (10%)
Query: 568 SRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY 627
S + G G ++S + P+ + C+G +Y++CN+ CP + R QCA N+
Sbjct: 266 SNNHGVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
Query: 628 YVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGE 687
+ W P+ +KCEL CQ+ V + V DGT C ++ ++C G+
Sbjct: 325 -PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
Query: 688 CVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQI 747
C +GCD +GS K DKCGVCGGDN+ C+ V G A G ++V+IP GA I I
Sbjct: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
Query: 748 EALEKSPHRIVVKNQ-----VTGSFILNPKGK-EATSRTFTAMGLEWEDAVEDAKESLKT 801
+ KS + + ++++ + G++ ++ GK E FT + A ES
Sbjct: 443 TEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYK--RPNEISSTAGESFLA 500
Query: 802 SGPLPEAIAILALPPTEGGPRSSLAYKYVI--HEDLLPLIG---------SNNVLLEEMD 850
GP E + + + P + Y+YVI + P + + ++ E
Sbjct: 501 EGPTNEILDVYMI---HQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRS 557
Query: 851 TYEWALKSWAPCSKACGGGI--QFTKYGCRRRRDHH--MVQRHLCDHKKRPKP-IRRRCN 905
E K + G FT + H H D+ P P RR
Sbjct: 558 QEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSR 617
Query: 906 QHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEA 962
H Q + TE CS +CGK G Q +C + TH+ P C PE
Sbjct: 618 DHNWKQ-LGTTE----CSTTCGK-GSQYPIFRC---VHRSTHEEAPESYCDSSMKPTPE- 667
Query: 963 RRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNAN-SLG----HCEG-DRPDT 1015
PC PCPA W +G WS+CS TCG G+Q RQV+CR AN SL C+ ++P+T
Sbjct: 668 EEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPET 727
Query: 1016 VQVCSLPAC 1024
C L C
Sbjct: 728 TSTCQLKIC 736
Score = 107 bits (267), Expect = 7e-23
Identities = 83/281 (29%), Positives = 122/281 (43%), Gaps = 41/281 (14%)
Query: 853 EWALKS-WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
EW +++ W CS CG G + C +V C+ K RP I C+ PC++
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPNDIEN-CDMGPCAK 795
Query: 912 PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV--MPAKACAGDRPEARRPCLRV 969
++TE CS CG GV+TR + C+ T+ V +P + C +RP PC
Sbjct: 796 SWFLTEWSERCSAECGA-GVRTRSVVCM------TNHVSSLPLEGCGNNRPAEATPCDNG 848
Query: 970 PCPA--QWRLGAWSQCSATCGEGIQQRQVVC-RTNANSL-----GHCEG-DRPDTVQVCS 1020
PC +W G+WSQCS CG G QQR+V+C R NA++ C ++P + Q C
Sbjct: 849 PCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCH 908
Query: 1021 LPACG----------------GNHQNSTVRA---DVWELGTPEGQWVPQS-EPLHPINKI 1060
L CG G + VR D+ + Q P+ E +P + +
Sbjct: 909 LKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCV 968
Query: 1061 SSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKKAS 1101
+ D+ C + V R C Y CC SC + A+
Sbjct: 969 PEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVAN 1009
Score = 93.6 bits (231), Expect = 1e-18
Identities = 53/178 (29%), Positives = 78/178 (43%), Gaps = 8/178 (4%)
Query: 852 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
+ W CS CG G Q+ + C R H CD +P P CN PC
Sbjct: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC-P 677
Query: 912 PVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
W EW CS++CG LG+Q R + C +N + V P + ++PE C C
Sbjct: 678 AFWDIGEWSECSKTCG-LGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
Query: 972 PAQWRLGA-WSQCSATCGEGIQQRQVVCRTNANSLGHCEGD----RPDTVQVCSLPAC 1024
++W++ W+ CS CG G + R V C +N + E RP+ ++ C + C
Sbjct: 737 -SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
Score = 39.3 bits (90), Expect = 0.023
Identities = 14/30 (46%), Positives = 19/30 (63%)
Query: 553 GQDGGWSSWTKFGSCSRSCGGGVRSRSRSC 582
G G W +W + +CSRSC GGV ++R C
Sbjct: 51 GAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 31.6 bits (70), Expect = 4.9
Identities = 41/172 (23%), Positives = 63/172 (36%), Gaps = 36/172 (20%)
Query: 560 SWTKFGS--CSRSCGGG-----VRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGT 612
+W + G+ CS +CG G R RS + +P + P E + CN CP
Sbjct: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
Query: 613 YEDFRAQQCAKRNSY----------YVHQNAKHSWVPY-----EPDDDAQKCEL-ICQSA 656
++ +C+K V+ N + PY E + C+L IC
Sbjct: 680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEW 739
Query: 657 DTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGV 708
Q+ D T CS P V R V C +G + D++C +
Sbjct: 740 ---------QIRTDWTSCSV--PCGVGQRTR--DVKCVSNIGDVVDDEECNM 778
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.447
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,164,414
Number of Sequences: 37866
Number of extensions: 3686081
Number of successful extensions: 19646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 641
Number of HSP's that attempted gapping in prelim test: 13405
Number of HSP's gapped (non-prelim): 4377
length of query: 1226
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1112
effective length of database: 13,930,794
effective search space: 15491042928
effective search space used: 15491042928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.