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Search of human proteins with 166235169
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
(546 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 1098 0.0
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 167 3e-41
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 162 1e-39
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 162 1e-39
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 149 6e-36
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 149 8e-36
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 141 1e-33
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 141 2e-33
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 130 3e-30
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 129 7e-30
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 129 9e-30
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 129 9e-30
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 129 9e-30
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 127 3e-29
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 124 2e-28
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 122 6e-28
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 122 1e-27
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 120 2e-27
gi|148746195 trichohyalin [Homo sapiens] 111 1e-24
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 111 2e-24
gi|52426743 cisplatin resistance-associated overexpressed protei... 110 4e-24
gi|19923485 cisplatin resistance-associated overexpressed protei... 110 4e-24
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 102 1e-21
gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo sapi... 101 2e-21
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 101 2e-21
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 100 3e-21
gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo s... 100 4e-21
gi|155030242 WD repeat domain 60 [Homo sapiens] 100 6e-21
gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo sap... 99 8e-21
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 99 1e-20
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 1098 bits (2841), Expect = 0.0
Identities = 546/546 (100%), Positives = 546/546 (100%)
Query: 1 MANNSPALTGNSQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNP 60
MANNSPALTGNSQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNP
Sbjct: 1 MANNSPALTGNSQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNP 60
Query: 61 MILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVG 120
MILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVG
Sbjct: 61 MILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVG 120
Query: 121 TGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFES 180
TGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFES
Sbjct: 121 TGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFES 180
Query: 181 FLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKI 240
FLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKI
Sbjct: 181 FLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKI 240
Query: 241 KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE 300
KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE
Sbjct: 241 KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE 300
Query: 301 RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN 360
RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN
Sbjct: 301 RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN 360
Query: 361 ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK 420
ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK
Sbjct: 361 ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK 420
Query: 421 KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTD 480
KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTD
Sbjct: 421 KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTD 480
Query: 481 SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK 540
SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK
Sbjct: 481 SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK 540
Query: 541 NKDETV 546
NKDETV
Sbjct: 541 NKDETV 546
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 167 bits (422), Expect = 3e-41
Identities = 96/327 (29%), Positives = 174/327 (53%), Gaps = 16/327 (4%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSP--RRSLSPRRSPRRSRSRSHHR 283
++ D++ + K + KE E +R ER R R +R +R + R R R
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165
Query: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRS---RSIDRGLERRRSRSRERHRSRS 340
E + +R+ ERE+E+ R ER +ER++E+ R +RG ER R R E R
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225
Query: 341 RSRDRKGDRR---DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGE 397
R DR+ DR+ +R+RE++ E ER R+ + DKER ER+++R+R R + + +R
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285
Query: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER-KHRSRSRSRNAGKRSRSRSKEKS 456
+++ + D++ R R+ +R+ ++E++ +R R RER + R R R R + R R KE+
Sbjct: 286 KRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQR---ETERDREKERE 342
Query: 457 SKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516
K K +++ + ++G +GR + E+ ++RE ++ +R+R +ER RD K
Sbjct: 343 RKRKRQTEMDRERNRQTGREGRRQA-ERERERERERDRQSARER---EERERDRDRDRQK 398
Query: 517 DQSDKHDRRRSQSIEQESQEKQHKNKD 543
++ + ++ R E E Q ++ K+++
Sbjct: 399 ERERQTEKDRDGQRETEKQREREKDRE 425
Score = 164 bits (414), Expect = 3e-40
Identities = 98/321 (30%), Positives = 162/321 (50%), Gaps = 25/321 (7%)
Query: 236 RPRKIKKDG-KEGAEEIDRHVERR--RSRSPRRSLSPRRSPRRSRSRSHHREG-----HG 287
R R+ ++D KE + DR +R+ R+R R R RR R R +E H
Sbjct: 147 RERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHS 206
Query: 288 SSSFDRELEREKERQ--RLEREAKEREKERRRSRSIDRGLERRRSRSRE----RHRSRSR 341
+RE ERE E + R + +ER+++R+ R ++ ER R+ RE + R R R
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266
Query: 342 SRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK 401
RDR DRR ++RER+ + +R RR +RD + ER ER++ERER RER++++ E+
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR-------ER 319
Query: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSR----SRERKHRSRSRSRNAGKRSRSRSKEKSS 457
+ + +++ R R+ +RD +KE++ R R RER ++ R +R R R +E+
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDR 379
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
+ E +E+ R R + R EK + + K++ R++ R ER +R K
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQ 439
Query: 518 QSDKHDRRRSQSIEQESQEKQ 538
+ + DR R + Q K+
Sbjct: 440 KGRERDRERQTDRQAGRQRKR 460
Score = 162 bits (409), Expect = 1e-39
Identities = 93/328 (28%), Positives = 172/328 (52%), Gaps = 13/328 (3%)
Query: 227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286
K+ D + R R+ +++ + + +R +R+R R RR R R R R RE
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRER--RREKDRHRKRDRHRERQRDREKE 104
Query: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGL--ERRRSRSRERHRSRSRSRD 344
DRE +R++E++R ++ +ERE ER R DR +R R R R+ + R R D
Sbjct: 105 RERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTD 164
Query: 345 RKGDR---RDRDREREKENERGRRRDRDYDKERGNERE-KERERSRERSKEQRSRGEVEE 400
R+ R R+R +ERE+E R RR+R+ +E+ N+ E + ER RER +E+ + E E
Sbjct: 165 RERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETER 224
Query: 401 KKHKEDKDDRRHRDDK-RDSKKEKKHSRSRSRER-KHRSRSRSRNAGKRSRSRSKEKSSK 458
K+ + + DR+ + ++ R+ + E++ + R ER K R R R R+ + R + +E+ +
Sbjct: 225 KRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTD 284
Query: 459 HKNE---SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDS 515
K + +++ +R R + R E+++KRE +E+ R+R R ER +++
Sbjct: 285 RKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERK 344
Query: 516 KDQSDKHDRRRSQSIEQESQEKQHKNKD 543
+ + + DR R++ +E + + + ++
Sbjct: 345 RKRQTEMDRERNRQTGREGRRQAERERE 372
Score = 162 bits (409), Expect = 1e-39
Identities = 94/324 (29%), Positives = 162/324 (50%), Gaps = 12/324 (3%)
Query: 234 KTRPRKIKKDG-KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFD 292
+ R R+ ++D KE + DR +R+R + R R R R R+ G +
Sbjct: 91 RDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERE 150
Query: 293 RELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR 352
R+ + EKER+R ++R+ ER R + +R R+ R RER R + + + R R
Sbjct: 151 RQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGR 210
Query: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRH 412
+RERE+E E R R D+ER +R+ ERER ++ +E+ S E E K +E + DR
Sbjct: 211 ERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDR 270
Query: 413 RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNE-SKEKSNKRS 471
D+R ++E++ R R R + + + +R R R +E++ K + E +E+ +R
Sbjct: 271 DRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQ 330
Query: 472 RSGSQGRTDSVEKSKKREHSPSKEKS--------RKRSRSKERSHKRDHSDSKDQSDK-H 522
R + R E+ +KR+ +E++ R+ R +ER +RD ++++ ++
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERER 390
Query: 523 DRRRSQSIEQESQ-EKQHKNKDET 545
DR R + E+E Q EK + ET
Sbjct: 391 DRDRDRQKERERQTEKDRDGQRET 414
Score = 157 bits (397), Expect = 2e-38
Identities = 99/303 (32%), Positives = 156/303 (51%), Gaps = 33/303 (10%)
Query: 231 QQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSS 290
Q+ + R R+ +K+ K DRH ER R R R +R R R+
Sbjct: 186 QERRERERQREKENKTE----DRHSERGRERERERETETETERKRQTDRERDRQ----RK 237
Query: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERR---RSRSRERHRSRSRSRDRKG 347
+RE E++ ER+R ER+KER R R DR +RR R R +R R R RDR+
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297
Query: 348 DR-RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406
+R R+R RERE+E ER R+R+R+ ++ER ER++E ER RE+ +E++ +K + +
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERK-------RKRQTE 350
Query: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEK 466
D R+R R+ +++ + R R RER +S +R R +R R R ++K +E+
Sbjct: 351 MDRERNRQTGREGRRQAERERERERERDRQS-AREREERERDRDRDRQKE-------RER 402
Query: 467 SNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR--SRSKERSHKRDHSDSKDQSDKHDR 524
++ R G + EK ++RE E+ R+R R K++ +RD D+ R
Sbjct: 403 QTEKDRDGQR----ETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQR 458
Query: 525 RRS 527
+RS
Sbjct: 459 KRS 461
Score = 156 bits (394), Expect = 5e-38
Identities = 86/286 (30%), Positives = 164/286 (57%), Gaps = 13/286 (4%)
Query: 264 RRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRL-EREAKEREKERRRSRSID 322
RR + SPRR H++ G DRE R+KER+R E+ ERE +R+R R +
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGD---DRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 323 RGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKE--RGNEREK 380
+ R+R R RER R R + R+R+ DR +RDR+REKE R + R+R+ ++E RG +R+
Sbjct: 85 KDRHRKRDRHRERQRDREKERERQTDR-ERDRQREKERNRQKERERETEREGERGRDRQT 143
Query: 381 ERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
+ +R RER ++ E + + ++ + R+R +R+ +K ++ R R R+R+ +++
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQ-RQTERNRQKEREREKNRQERRERERQREKENKTE 202
Query: 441 SRNAGKRSRSRSKEKSSKHKNESKEKSNK---RSRSGSQGRTDSVEKSKKREHSPSKEKS 497
R++ +R R R +E+ ++ + E K ++++ R R + R E+ + E ++K
Sbjct: 203 DRHS-ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKE 261
Query: 498 RKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
R+R R ++R R + + Q+D+ +RR++ ++E++ K+ + ++
Sbjct: 262 RERERDRDRDRDRRQKERERQTDRKRQRRTER-DRETERKRERQRE 306
Score = 136 bits (342), Expect = 6e-32
Identities = 81/271 (29%), Positives = 140/271 (51%), Gaps = 24/271 (8%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
++ +++ KT R ++ G+E E + E R R R +R R R + RE
Sbjct: 192 ERQREKENKTEDRHSER-GRERERERETETETERKRQTDRERDRQRKTEREREKQAERER 250
Query: 286 HGSSSFDRELEREKERQR-LEREAKEREKERR----------RSRSIDRGLERRRSRSRE 334
+R+ ERE+ER R +R+ +++E+ER+ R R +R ER+R R RE
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERE 310
Query: 335 RHRSRSRSRDRKGDR-----RDRDREREKENERGRRRDRDYDKERGNE------REKERE 383
R R+R R R+R+ +R R+ +R+REKE ER R+R + D+ER + R+ ERE
Sbjct: 311 RERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERE 370
Query: 384 RSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER-KHRSRSRSR 442
R RER ++++S E EE++ D+D ++ R+ + + ++ + + RER K R R R
Sbjct: 371 RERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGR 430
Query: 443 NAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
G+ + + + + ++ +R RS
Sbjct: 431 ERGREREKQKGRERDRERQTDRQAGRQRKRS 461
Score = 127 bits (318), Expect = 3e-29
Identities = 85/257 (33%), Positives = 133/257 (51%), Gaps = 15/257 (5%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPR-RSRSRSHHREGHGS 288
D+Q KT + K+ +E A E R ER + R R R R + R R R+
Sbjct: 233 DRQRKTEREREKQAERERASE--RETERDKERERERDRDRDRDRRQKERERQTDRKRQRR 290
Query: 289 SSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGD 348
+ DRE ER++ERQR +ERE+ER R R +R ER R R RE R R + R+RK
Sbjct: 291 TERDRETERKRERQR----ERERERERNRKRERERERERERERQRETERDREKERERKRK 346
Query: 349 RR-DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407
R+ + DRER ++ R RR + ++ER ER+++ R RE + R R +E++ + +K
Sbjct: 347 RQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406
Query: 408 DDRRHRDDKRDSKKEKKHSRSRSRER-KHRSRSRSRNAGK-RSRSRSKEK-SSKHKNESK 464
D RD +R+++K+++ + R ER + R R R + G+ R R R ++ + + + S
Sbjct: 407 D----RDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRST 462
Query: 465 EKSNKRSRSGSQGRTDS 481
N R+ G S
Sbjct: 463 LYVNPPPRTARSGVVQS 479
Score = 116 bits (291), Expect = 5e-26
Identities = 65/259 (25%), Positives = 134/259 (51%), Gaps = 23/259 (8%)
Query: 306 REAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRR 365
R +E RRR G + + +R R+R + R+R+ ++R +RE +++ ER R
Sbjct: 29 RRPGSQESPRRRGL----GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 366 RDRDYDKERGNEREKERERSRER--SKEQRSRGEVEEKKHKE---------------DKD 408
+DR ++R ER+++RE+ RER +E+ + E E + KE D
Sbjct: 85 KDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTD 144
Query: 409 DRRHRDDKRDSKKEKKHSRSRSRERK-HRSRSRSRNAGK-RSRSRSKEKSSKHKNESKEK 466
+R R+ +RD++KE++ R R+R+ R+R + R K R R +E+ + +N+++++
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204
Query: 467 SNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRR 526
++R R + R E +KR+ +++ RK R +E+ +R+ + ++ +R R
Sbjct: 205 HSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264
Query: 527 SQSIEQESQEKQHKNKDET 545
+ +++ +Q + + +T
Sbjct: 265 ERDRDRDRDRRQKERERQT 283
Score = 95.9 bits (237), Expect = 8e-20
Identities = 64/224 (28%), Positives = 114/224 (50%), Gaps = 8/224 (3%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
Q+ +++ + ++ ++ +E E R ER R + R + R R+R REG
Sbjct: 304 QRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREG 363
Query: 286 HGSSSFDRELEREKERQRL-EREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRD 344
+ +RE ERE++RQ ERE +ER+++R R + +R E+ R RE + R R +D
Sbjct: 364 RRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKD 423
Query: 345 RKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR-GEVEEKKH 403
R+ +R R+R RE+E ++GR RDR+ +R R+++R + +R G V+ +
Sbjct: 424 RESER-GRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPN 482
Query: 404 KEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR 447
+ + R + S ++ K + +R + SR R AG+R
Sbjct: 483 RPTRGIR-----WKSSPEDPKAASTRFPWGRPAKASRGRVAGRR 521
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 162 bits (409), Expect = 1e-39
Identities = 99/297 (33%), Positives = 163/297 (54%), Gaps = 37/297 (12%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR 316
+ R RS S RS RS S+SH R R+ + K R R ++ R+K+RR
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSR---------RKRSQSKHRSRSHNRSRSRQKDRR 349
Query: 317 RSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK------ENERGRRRDRDY 370
RS+S + +R +SR R + RSRS SRD++ D R++ +E+E+ E ER R ++R+
Sbjct: 350 RSKSPHK--KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407
Query: 371 DKERGN--EREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR- 427
+KERG +R+KERE+ RE+ KE + R EK+H++D+D + ++ ++ ++EK S+
Sbjct: 408 EKERGKNKDRDKEREKDREKDKE-KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKE 466
Query: 428 ---SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK 484
R +++K R+ RS NA +RSRS S+E+ +R RS S R+ K
Sbjct: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRER-------------RRRRSRSSSRSPRTSK 513
Query: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541
+ KR+ S S + + K+R +RDH + + ++ R S +++ +EK KN
Sbjct: 514 TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKN 570
Score = 146 bits (368), Expect = 5e-35
Identities = 97/291 (33%), Positives = 162/291 (55%), Gaps = 32/291 (10%)
Query: 253 RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
R +RRRS+SP + S R R+SRSRSH R+ +R+ R++++ KER
Sbjct: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD-----------KRKDTREKIKE--KERV 390
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
KE+ DR ER R + RE+ + R +++DR + R++DRE++KE +R R R+++++K
Sbjct: 391 KEK------DREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDREREREKEHEK 443
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
+R E+EKE+++ +ER K++ E++EK+ K D++ R R S + SRS SRE
Sbjct: 444 DRDKEKEKEQDKEKEREKDRSK--EIDEKR----KKDKKSRTPPR-SYNASRRSRSSSRE 496
Query: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP 492
R+ R RSRS + R+ K KSS ++ S NK+ + + R D + + ++RE S
Sbjct: 497 RRRR-RSRSSSRSPRTSKTIKRKSS--RSPSPRSRNKKDKKREKER-DHISERRERERST 552
Query: 493 SKEKSRKRSRSKERSHKRDHS-DSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
S KS KE+ K S K+ + + D S+ ++ + + +NK
Sbjct: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
Score = 119 bits (299), Expect = 5e-27
Identities = 73/267 (27%), Positives = 134/267 (50%), Gaps = 11/267 (4%)
Query: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
+ + ++R +E Q A E E + R R RS+SR +S SR + +
Sbjct: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 331
Query: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR--SRGEVEEKKHKE 405
R R R + ++ RRR + K+R RE+ + RSR S+++R +R +++EK+ +
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391
Query: 406 DKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK-RSRSRSKEKS---SKHKN 461
+KD + R+ +++ +KEK+ +++ R+ K R + R ++ K R R R KE K K
Sbjct: 392 EKDREKEREREKEREKEKERGKNKDRD-KEREKDREKDKEKDREREREKEHEKDRDKEKE 450
Query: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
+ ++K +R + S+ + +K KK P + +RSRS R +R S S +S +
Sbjct: 451 KEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR 510
Query: 522 HD----RRRSQSIEQESQEKQHKNKDE 544
R+ S+S S+ K+ K +++
Sbjct: 511 TSKTIKRKSSRSPSPRSRNKKDKKREK 537
Score = 94.0 bits (232), Expect = 3e-19
Identities = 62/238 (26%), Positives = 110/238 (46%), Gaps = 14/238 (5%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
D++ TR KIK+ KE +E DR E+ R R R R + R + ++
Sbjct: 375 DKRKDTR-EKIKE--KERVKEKDR--EKEREREKEREKEKERGKNKDRDKEREKDREKDK 429
Query: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR 349
DRE EREKE ++ + KE+E+++ + R DR E R +++ +SR+ R R
Sbjct: 430 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK-KSRTPPRSYNASR 488
Query: 350 RDRDREREKENERGRRRDRD-----YDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404
R R RE+ R R R K + + R R+++ K ++ R + E++ +
Sbjct: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER 548
Query: 405 EDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR---SRSRNAGKRSRSRSKEKSSKH 459
E R + RD K++ + + + +E++H S S+ + R++E +H
Sbjct: 549 ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606
Score = 84.7 bits (208), Expect = 2e-16
Identities = 66/229 (28%), Positives = 105/229 (45%), Gaps = 35/229 (15%)
Query: 226 QKNIDQQIKTRPRKIKKDG-KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE 284
+K+ ++IK + R +KD KE E +R E+ R ++ R + + + + RE
Sbjct: 377 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436
Query: 285 GHGSSSFDRELEREKERQRLEREAKEREKE--------------------RRRSRSIDRG 324
DR+ E+EKE+ + + K+R KE RRSRS R
Sbjct: 437 REKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE 496
Query: 325 LERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERER 384
RRRSRS R S++ RK R R R K++++ R ++RD+ ER RE+ER
Sbjct: 497 RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK-REKERDHISER---RERERST 552
Query: 385 SRERSKEQRSRGE--------VEEKKHKEDKDD--RRHRDDKRDSKKEK 423
S +S R E ++EK+H ++ D + DDK + E+
Sbjct: 553 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/177 (25%), Positives = 77/177 (43%), Gaps = 17/177 (9%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVER-RRSRSP-------RRSLSPRRSPRRSR 277
+K+ D++ + K K+ K+ ++EID ++ ++SR+P RRS S R RR R
Sbjct: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
Query: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKER---------RRSRSIDRGLERR 328
SRS R S + R+ R + ++ K+REKER RS S+ + R
Sbjct: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 561
Query: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
+ + S S D +E +++ R + + + GN + E S
Sbjct: 562 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLS 618
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/108 (25%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 439 SRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR 498
+ S NA + + + ++K E ++ + S KS +R+ S+ +R
Sbjct: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313
Query: 499 KRSRSKERSH-KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
+SRS +SH +R S SK +S H+R RS+ ++ + HK + ++
Sbjct: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 361
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 162 bits (409), Expect = 1e-39
Identities = 99/297 (33%), Positives = 163/297 (54%), Gaps = 37/297 (12%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR 316
+ R RS S RS RS S+SH R R+ + K R R ++ R+K+RR
Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHSR---------RKRSQSKHRSRSHNRSRSRQKDRR 233
Query: 317 RSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK------ENERGRRRDRDY 370
RS+S + +R +SR R + RSRS SRD++ D R++ +E+E+ E ER R ++R+
Sbjct: 234 RSKSPHK--KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 291
Query: 371 DKERGN--EREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR- 427
+KERG +R+KERE+ RE+ KE + R EK+H++D+D + ++ ++ ++EK S+
Sbjct: 292 EKERGKNKDRDKEREKDREKDKE-KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKE 350
Query: 428 ---SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK 484
R +++K R+ RS NA +RSRS S+E+ +R RS S R+ K
Sbjct: 351 IDEKRKKDKKSRTPPRSYNASRRSRSSSRER-------------RRRRSRSSSRSPRTSK 397
Query: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541
+ KR+ S S + + K+R +RDH + + ++ R S +++ +EK KN
Sbjct: 398 TIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKN 454
Score = 146 bits (368), Expect = 5e-35
Identities = 97/291 (33%), Positives = 162/291 (55%), Gaps = 32/291 (10%)
Query: 253 RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
R +RRRS+SP + S R R+SRSRSH R+ +R+ R++++ KER
Sbjct: 228 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRD-----------KRKDTREKIKE--KERV 274
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
KE+ DR ER R + RE+ + R +++DR + R++DRE++KE +R R R+++++K
Sbjct: 275 KEK------DREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDREREREKEHEK 327
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
+R E+EKE+++ +ER K++ E++EK+ K D++ R R S + SRS SRE
Sbjct: 328 DRDKEKEKEQDKEKEREKDRSK--EIDEKR----KKDKKSRTPPR-SYNASRRSRSSSRE 380
Query: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP 492
R+ R RSRS + R+ K KSS ++ S NK+ + + R D + + ++RE S
Sbjct: 381 RRRR-RSRSSSRSPRTSKTIKRKSS--RSPSPRSRNKKDKKREKER-DHISERRERERST 436
Query: 493 SKEKSRKRSRSKERSHKRDHS-DSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
S KS KE+ K S K+ + + D S+ ++ + + +NK
Sbjct: 437 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 487
Score = 119 bits (299), Expect = 5e-27
Identities = 73/267 (27%), Positives = 134/267 (50%), Gaps = 11/267 (4%)
Query: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
+ + ++R +E Q A E E + R R RS+SR +S SR + +
Sbjct: 156 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 215
Query: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR--SRGEVEEKKHKE 405
R R R + ++ RRR + K+R RE+ + RSR S+++R +R +++EK+ +
Sbjct: 216 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 275
Query: 406 DKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK-RSRSRSKEKS---SKHKN 461
+KD + R+ +++ +KEK+ +++ R+ K R + R ++ K R R R KE K K
Sbjct: 276 EKDREKEREREKEREKEKERGKNKDRD-KEREKDREKDKEKDREREREKEHEKDRDKEKE 334
Query: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
+ ++K +R + S+ + +K KK P + +RSRS R +R S S +S +
Sbjct: 335 KEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR 394
Query: 522 HD----RRRSQSIEQESQEKQHKNKDE 544
R+ S+S S+ K+ K +++
Sbjct: 395 TSKTIKRKSSRSPSPRSRNKKDKKREK 421
Score = 94.0 bits (232), Expect = 3e-19
Identities = 62/238 (26%), Positives = 110/238 (46%), Gaps = 14/238 (5%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
D++ TR KIK+ KE +E DR E+ R R R R + R + ++
Sbjct: 259 DKRKDTR-EKIKE--KERVKEKDR--EKEREREKEREKEKERGKNKDRDKEREKDREKDK 313
Query: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR 349
DRE EREKE ++ + KE+E+++ + R DR E R +++ +SR+ R R
Sbjct: 314 EKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK-KSRTPPRSYNASR 372
Query: 350 RDRDREREKENERGRRRDRD-----YDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404
R R RE+ R R R K + + R R+++ K ++ R + E++ +
Sbjct: 373 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRER 432
Query: 405 EDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR---SRSRNAGKRSRSRSKEKSSKH 459
E R + RD K++ + + + +E++H S S+ + R++E +H
Sbjct: 433 ERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 490
Score = 84.7 bits (208), Expect = 2e-16
Identities = 66/229 (28%), Positives = 105/229 (45%), Gaps = 35/229 (15%)
Query: 226 QKNIDQQIKTRPRKIKKDG-KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE 284
+K+ ++IK + R +KD KE E +R E+ R ++ R + + + + RE
Sbjct: 261 RKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 320
Query: 285 GHGSSSFDRELEREKERQRLEREAKEREKE--------------------RRRSRSIDRG 324
DR+ E+EKE+ + + K+R KE RRSRS R
Sbjct: 321 REKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRE 380
Query: 325 LERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERER 384
RRRSRS R S++ RK R R R K++++ R ++RD+ ER RE+ER
Sbjct: 381 RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK-REKERDHISER---RERERST 436
Query: 385 SRERSKEQRSRGE--------VEEKKHKEDKDD--RRHRDDKRDSKKEK 423
S +S R E ++EK+H ++ D + DDK + E+
Sbjct: 437 SMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 485
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/177 (25%), Positives = 77/177 (43%), Gaps = 17/177 (9%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVER-RRSRSP-------RRSLSPRRSPRRSR 277
+K+ D++ + K K+ K+ ++EID ++ ++SR+P RRS S R RR R
Sbjct: 326 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 385
Query: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKER---------RRSRSIDRGLERR 328
SRS R S + R+ R + ++ K+REKER RS S+ + R
Sbjct: 386 SRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDR 445
Query: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
+ + S S D +E +++ R + + + GN + E S
Sbjct: 446 DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLS 502
Score = 44.3 bits (103), Expect = 3e-04
Identities = 27/108 (25%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 439 SRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR 498
+ S NA + + + ++K E ++ + S KS +R+ S+ +R
Sbjct: 138 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 197
Query: 499 KRSRSKERSH-KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
+SRS +SH +R S SK +S H+R RS+ ++ + HK + ++
Sbjct: 198 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKS 245
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 149 bits (376), Expect = 6e-36
Identities = 101/315 (32%), Positives = 160/315 (50%), Gaps = 21/315 (6%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
R ++++D + +DR +RR R+ R R R R R R+ +RE
Sbjct: 650 RNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDR------EREK 703
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
ERE ER+R +EREKER R R DR +R R R RER R + R R+R+ +RE
Sbjct: 704 ERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE------ERE 757
Query: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD- 414
RE+E ER R R+R+ ++ER ER+KERER R+ + + R + EK+ +E ++DR RD
Sbjct: 758 RERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKR-EEIREDRNPRDG 816
Query: 415 -DKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--NESKEKSNKRS 471
D+R SKK ++ S S R+ R R + + + +K+ KH+ ++ RS
Sbjct: 817 HDERKSKKRYRNEGSPS-PRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRS 875
Query: 472 RSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSD-SKDQSD--KHDRRRSQ 528
S S D + K+ + P +++S +R +E K D ++Q++ + R R+Q
Sbjct: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
Query: 529 SIEQESQEKQHKNKD 543
I Q + + D
Sbjct: 936 DIIGHHQSEDRETSD 950
Score = 145 bits (367), Expect = 7e-35
Identities = 105/321 (32%), Positives = 154/321 (47%), Gaps = 41/321 (12%)
Query: 250 EIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSF-----DRELEREKERQ-- 302
E DR+ ER R S RR R R + R+ SS + ELER++ R+
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
Query: 303 ---RLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKE 359
R++ ER +ER R R DR ER R R R+R R + R +R+ R+R+REREKE
Sbjct: 664 RVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE-RAREREREREKE 722
Query: 360 NERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDS 419
+R R RDRD+D+ER ERE++RE+ RER +E+R R E++ + +++ R R +RD
Sbjct: 723 RDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDK 782
Query: 420 KKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS-GSQGR 478
++E R+R + + R+ + R +E + + KS KR R+ GS
Sbjct: 783 ERE--------RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSP 834
Query: 479 TDSVEKSKKREHSP----------SKEKSR--------KRSRSKERSH-KRDHSDSKDQS 519
S ++REHSP EK R + SRS SH D +
Sbjct: 835 RQS--PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEE 892
Query: 520 DKHDRRRSQSIEQESQEKQHK 540
D+ R+ S E QE + K
Sbjct: 893 DRKPERKESSRRYEEQELKEK 913
Score = 125 bits (314), Expect = 1e-28
Identities = 108/325 (33%), Positives = 153/325 (47%), Gaps = 40/325 (12%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSH------HREGHGSSSF---DRELEREKERQRLERE 307
R R R P R R S+ SH H SS+ DR ER+ Q +
Sbjct: 562 RSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSS 621
Query: 308 AKER--EKERRRSRSIDRGLE---RRRSRSRERHRSRSRSR---DRKGDRRD-----RDR 354
+ R E++RR +R D+ R + R+ E R R DR DRRD RDR
Sbjct: 622 FERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDR 681
Query: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKE---QRSRGEVEEKKHKEDKDDRR 411
ERE++ ER R R+R+ D+ER ERE ERER+RER +E +R R ++ H +++ R
Sbjct: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
Query: 412 HRDDKRD---SKKEKKHSRSRSRER---KHRSRSRSRNAGK-RSRSRSKEKSSKHKNESK 464
RD +++ ++E++ R R RER + R R R+R K R R R E K +++ +
Sbjct: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
Query: 465 EKSNKRSRSGSQGRTDSVEKSKKR---EHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
EK + + KSKKR E SPS +S KR R E S D +S D ++
Sbjct: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRR--EHSPDSDAYNSGDDKNE 859
Query: 522 HDRRRSQSI---EQESQEKQHKNKD 543
R SQ + E S H +D
Sbjct: 860 KHRLLSQVVRPQESRSLSPSHLTED 884
Score = 110 bits (275), Expect = 3e-24
Identities = 89/326 (27%), Positives = 146/326 (44%), Gaps = 35/326 (10%)
Query: 235 TRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE-------GHG 287
T P + + G+ E E R + S S S R+ R RSR E G
Sbjct: 521 TYPEESRSYGRNHLREESSRTEIR-NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSR 579
Query: 288 SSSFDRELEREKERQRLEREAKEREKER-----RRSRSIDRGLERRRSRSRERHRSRSRS 342
S D E + E++R R ++ D ERR ER R +R
Sbjct: 580 GSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHG---ERDRRDNRE 636
Query: 343 RDRKGDRRDRDREREKENERGRRR-----DRDYDKERGNEREKERERSRERSKEQRSRGE 397
RD++ R + R E ER RR DR D+ RE++RER R+R +E R R
Sbjct: 637 RDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERE-RERER 695
Query: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSS 457
+++ +++++ R R +R+ ++EK+ R R R+R H R R +R R R +EK
Sbjct: 696 ERDREREKERELERERAREREREREKERDRERDRDRDH-DRER-----ERERERDREKER 749
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK-RDHSDSK 516
+ + E +E+ +R R + E+ ++RE + ++K R+R R E K RD K
Sbjct: 750 EREREERERERERERERER------ERERERERARERDKERERQRDWEDKDKGRDDRREK 803
Query: 517 DQSDKHDRRRSQSIEQESQEKQHKNK 542
+ + DR ++ +K+++N+
Sbjct: 804 REEIREDRNPRDGHDERKSKKRYRNE 829
Score = 107 bits (266), Expect = 4e-23
Identities = 89/342 (26%), Positives = 153/342 (44%), Gaps = 36/342 (10%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSP--RRSRSRSHHREGHGSSSFDR 293
R + +D ++ E D + + SR PR S S R + R R HR+ R
Sbjct: 468 RELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESR 527
Query: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD-- 351
R R+ R + R + R SRS R RSR R SR +G + D
Sbjct: 528 SYGRNHLREESSR-TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSH 586
Query: 352 ------------------RDREREKENERGRRRDRDYDKERGN-EREKERERSRERSKEQ 392
RDR E++N R + RD +++ G +R RER + S
Sbjct: 587 SSNSNYHDSWETRSSYPERDRYPERDN-RDQARDSSFERRHGERDRRDNRERDQRPSSPI 645
Query: 393 RSRGEVEEKKHKEDKDDRR--HRDDKRDSK-KEKKHSRSRSRER-KHRSRSRSRNAGK-- 446
R +G +E + E +++RR DD+RD + +E+ R R RER + R R R R K
Sbjct: 646 RHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKER 705
Query: 447 ---RSRSRSKEKS-SKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSR 502
R R+R +E+ K ++ +++ R + R EK ++RE +E+ R+R R
Sbjct: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE-ERERERERER 764
Query: 503 SKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
+ER +R+ ++++ + +R+R + + ++ + + ++E
Sbjct: 765 ERERERERERERARERDKERERQRDWEDKDKGRDDRREKREE 806
Score = 105 bits (262), Expect = 1e-22
Identities = 85/335 (25%), Positives = 137/335 (40%), Gaps = 27/335 (8%)
Query: 235 TRPRKIKKDGKEGAEEIDRHVER-RRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293
+R K +D ++ D H R R R R RS R+H RE +
Sbjct: 486 SRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRN 545
Query: 294 ELEREKERQ-RLEREAKER-------EKERRRSRSIDRGLERRRSRSRERHRSRSR--SR 343
E E + R +R + R EK R SR S + +RS R
Sbjct: 546 ESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPER 605
Query: 344 DRKGDRRDRDRERE-----KENERGRRRDRDYD-------KERGNEREKERERSRERSKE 391
DR +R +RD+ R+ + ER RR +R+ D + +G E ER+ RE +
Sbjct: 606 DRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRV 665
Query: 392 QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE-RKHRSRSRSRNAGK---R 447
R +E+ + D++ R R+ +R+ ++E+ R + RE + R+R R R K R
Sbjct: 666 DRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDR 725
Query: 448 SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS 507
R R ++ + + E + K + R E+ ++RE +E+ R R R KER
Sbjct: 726 ERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERE 785
Query: 508 HKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
+RD D D +R + E + H +
Sbjct: 786 RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDER 820
Score = 97.1 bits (240), Expect = 4e-20
Identities = 87/350 (24%), Positives = 143/350 (40%), Gaps = 68/350 (19%)
Query: 262 SPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE----RQRLEREAKEREKERRR 317
SP+R SP R R + H S S DR ER ++ R R + +ERE E+ +
Sbjct: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ 440
Query: 318 SRSIDR--------GLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDR- 368
S S D G +RR +R R SRD + R RD R+ + R R R
Sbjct: 441 SSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS 500
Query: 369 -----DYDKERGNER--------EKERERSRERSKEQRSRGEVEEKKHKED----KDDRR 411
DY G + E+ R R +E+ SR E+ + E ++DR
Sbjct: 501 TRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRM 560
Query: 412 HRDDKRDSKKEKKHSRSR--SRERKHRSRS--------------RSRNAGKRSRSRSKEK 455
R R + +K SR S+ H S S R R + +R ++++
Sbjct: 561 GRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
Query: 456 SSKHKNESKEKSNKRSRS-------GSQGRTDSVEKSKKRE---------------HSPS 493
S + ++ +++ + R R QGR D +E+ ++RE
Sbjct: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
Query: 494 KEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
+E+ R R R +ER +RD K++ + +R R + E+E + + +++D
Sbjct: 681 RERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730
Score = 85.9 bits (211), Expect = 9e-17
Identities = 97/413 (23%), Positives = 160/413 (38%), Gaps = 112/413 (27%)
Query: 230 DQQIKTRPRKIKKDGKEGAE---------EIDRHVERRRSRSPRRSLSPRRSPRRSRSRS 280
D++ + R R+ ++D + E E +R +ER R+R R R R R R
Sbjct: 673 DERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRD 732
Query: 281 HHREGHGSSSFDRELEREKERQRLERE-----------------AKEREKERRRSRSIDR 323
H RE DRE ERE+ER+ ERE A+ER+KER R R +
Sbjct: 733 HDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWED 792
Query: 324 -----------------------GLERRRSRSR--------------------------- 333
G + R+S+ R
Sbjct: 793 KDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYN 852
Query: 334 ------ERHR----------SRSRS-----RDRKGDRRDRDREREKENERGRRRDRDYDK 372
E+HR SRS S DR+G ++ DR+ E++ E RR + K
Sbjct: 853 SGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERK-ESSRRYEEQELK 911
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKD--DRRHRDDKRDSKKEKKHSRSRS 430
E+ + +K+RE++ + ++ ED++ DR H ++K+ +K +KK + +
Sbjct: 912 EKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKK 971
Query: 431 RERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREH 490
+ R + + S +K K K S EK K+S+ S + + K++
Sbjct: 972 EDDVGIERGNIETTSEDGQVFSPKKGQKKK--SIEKKRKKSKGDSDISDEEAAQQSKKKR 1029
Query: 491 SP------SKEKSRKRSRSK----ERSHKRDHSDSKDQSDKHDRRRSQSIEQE 533
P +KE+ + K E S K++ + D SD+ R++ E E
Sbjct: 1030 GPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAE 1082
Score = 81.6 bits (200), Expect = 2e-15
Identities = 74/323 (22%), Positives = 135/323 (41%), Gaps = 33/323 (10%)
Query: 219 PRIPVPVQKNI--------DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPR 270
P P P+ ++I ++K R + +DGK+ + +R +R R RS SP
Sbjct: 264 PSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFER---QREKRDKPRSTSPA 320
Query: 271 RSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLER--R 328
S HH S S ++R + ++R S S R L R
Sbjct: 321 GQHHSPISSRHHSSSSQSGS------------SIQRHSPSPRRKRTPSPSYQRTLTPPLR 368
Query: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRER 388
RS S S S + ++ R R REK R + +D+ + +R RE+
Sbjct: 369 RSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREK 428
Query: 389 SKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRS 448
+ E ++ ++ +DDR RD + +++ + +R R R R SR S
Sbjct: 429 DSREEREYEQDQSSSRDHRDDREPRDGR--DRRDARDTRDRRELRDSRDMRDSREMRDYS 486
Query: 449 RSRSKEKSSKHKNESKEKSNKRSRSG--SQGRTDSV-EKSKKREHSPSKEKSRKRSRSKE 505
R + + + +++ + R R G + + D+ E+S+ + +E+S SR++
Sbjct: 487 RDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES---SRTEI 543
Query: 506 RSHKRDHSDSKDQSDKHDRRRSQ 528
R+ R+ S S+ ++D+ R R +
Sbjct: 544 RNESRNESRSEIRNDRMGRSRGR 566
Score = 79.3 bits (194), Expect = 8e-15
Identities = 77/285 (27%), Positives = 123/285 (43%), Gaps = 44/285 (15%)
Query: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPR---RSLSPRRSPRRSRSRSHHREGHGSSS 290
KT+ +I + K +++ R R + S R RS S RRS S + H R G S
Sbjct: 1237 KTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSG----S 1292
Query: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR- 349
FD +R +ER R E + R R RER +R R DR D+
Sbjct: 1293 FDSR-DRLQERDRYEHD---------------------RERERERRDTRQREWDRDADKD 1330
Query: 350 --RDRDREREKENERGRRRDRDYDKERGNER------EKERERSRERSKEQRSRGEVEEK 401
R+RDR+R +E ER R RD+ D +R ER E++R+R R+R+ E ++E
Sbjct: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFES---SQIESV 1387
Query: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461
K E K + H +RD + + S + +ER + + + ++S E +
Sbjct: 1388 KRCEAKLEGEH---ERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDD 1444
Query: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKER 506
ESK SG+ + + + E + R+ + +E+
Sbjct: 1445 ESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
Score = 72.8 bits (177), Expect = 8e-13
Identities = 78/272 (28%), Positives = 112/272 (41%), Gaps = 29/272 (10%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPR----RSPRRSRSRSHHREGHGSSSF 291
+P K+ G+ +R R RSP + R +S R+ S R+ + S
Sbjct: 1182 KPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSL 1241
Query: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS---RDRKGD 348
+ ER+ +L+R R R S R S + SRS S RDR +
Sbjct: 1242 EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQE 1301
Query: 349 R----RDRDREREKENERGRRRDRDYDKE----RGNEREKERERSRERSKEQ---RSRGE 397
R DR+RERE+ + R R DRD DK+ R +R +ERER RER K + R R
Sbjct: 1302 RDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERER 1361
Query: 398 VEEKKHKEDKD---DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKE 454
+ + D+D DR + +S K + ER S SR S + KE
Sbjct: 1362 LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRD------SLALDKE 1415
Query: 455 KSSKHKN--ESKEKSNKRSRSGSQGRTDSVEK 484
+ K + E++NK R+ S D K
Sbjct: 1416 RMDKDLGSVQGFEETNKSERTESLEAGDDESK 1447
Score = 68.2 bits (165), Expect = 2e-11
Identities = 73/300 (24%), Positives = 123/300 (41%), Gaps = 21/300 (7%)
Query: 260 SRSPRRSLSPR-RSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR-R 317
+RS R S R RSP S HR G S R L R R + ++ E ER+ R
Sbjct: 1195 NRSNRSHTSGRLRSPSND---SAHRSGDDQSGRKRVLH-SGSRDREKTKSLEITGERKSR 1250
Query: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK-ERGN 376
+ RG E RS S +R SRS S R DR + R R ++ D+ E
Sbjct: 1251 IDQLKRG-EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDR 1309
Query: 377 EREKERERSRERSKEQ---------RSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR 427
ERE+ER +R+R ++ R R + E++ + ++D RR D +R+ R
Sbjct: 1310 ERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVER 1369
Query: 428 SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKS---NKRSRSGSQGRTDSVEK 484
R R+R S + KR ++ + + + + S +K G E+
Sbjct: 1370 DRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEE 1429
Query: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
+ K E + S E S+ + +H + D + + ++++++ + +E
Sbjct: 1430 TNKSERTESLEAGDDESKLDD-AHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEE 1488
Score = 66.6 bits (161), Expect = 5e-11
Identities = 76/355 (21%), Positives = 137/355 (38%), Gaps = 46/355 (12%)
Query: 227 KNIDQQIKTRPRK---------IKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSR 277
KN Q + T P+K ++K+ G ++ + R+P S +
Sbjct: 90 KNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPE---SEEENVEWET 146
Query: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHR 337
+R G + + EL E +RQ+++RE + E+E R + ++ S E R
Sbjct: 147 NRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKRE---EIIIKKEVSPEVVR 203
Query: 338 SR-SRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
S+ S S + + R+ ++ ++DR +++R +SK++ R
Sbjct: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRT 263
Query: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS 456
ED + +K K K ++R+ K R R R KR + RS +
Sbjct: 264 PSPPPPIPEDIALGKKYKEKY---KVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPA 320
Query: 457 SKHKNE-SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS------------------ 497
+H + S + S+SGS + S +KR SPS +++
Sbjct: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS 380
Query: 498 ---RKRSRSKERSHKR-----DHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
RK+S + RS R DH + D+ RR + + +EK + + E
Sbjct: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE 435
Score = 65.9 bits (159), Expect = 9e-11
Identities = 73/270 (27%), Positives = 114/270 (42%), Gaps = 30/270 (11%)
Query: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRER-HRSRSRSRDRKGDRRDRD 353
+E + R+ ++++ R +RS G R RS S + HRS RK
Sbjct: 1175 IEDAQHRKPMDQKRSSSLGSNRSNRSHTSG--RLRSPSNDSAHRSGDDQSGRKRVLHSGS 1232
Query: 354 REREKENE---RGRRRDRDYDKERG-------NEREKERERSRERSKEQRSRGEVEEKKH 403
R+REK G R+ R +RG ++R+ R S RS + R +V +
Sbjct: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR-QVHSRSG 1291
Query: 404 KEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGK---RSRSRSKEKSSKH 459
D DR D+ + H R R RER+ R R R+A K R+R R + + +
Sbjct: 1292 SFDSRDRLQERDRYE------HDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERER 1345
Query: 460 KNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR----KRSRSK-ERSHKRDHSD 514
+ E ++K R + +DSVE+ + R+ + E S+ KR +K E H+RD
Sbjct: 1346 ERE-RDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLES 1404
Query: 515 SKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
+ S D+ R Q + NK E
Sbjct: 1405 TSRDSLALDKERMDKDLGSVQGFEETNKSE 1434
Score = 62.8 bits (151), Expect = 8e-10
Identities = 63/266 (23%), Positives = 113/266 (42%), Gaps = 26/266 (9%)
Query: 292 DRELEREKERQRLER--------EAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
+ + R+ R R+E+ E + K + RS G R +RS R RS S
Sbjct: 1153 NEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLG-SNRSNRSHTSGRLRSPSN 1211
Query: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSK--EQRSRGEVEEK 401
D R +++ GR+R + R E+ K E + ER +Q RGE
Sbjct: 1212 D--------SAHRSGDDQSGRKRVL-HSGSRDREKTKSLEITGERKSRIDQLKRGEPSRS 1262
Query: 402 KHKEDKDDRRHRDDKRDSKKEKK-HSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK 460
+ +D R H + + +++ HSRS S + + R + R R R R R + + + +
Sbjct: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQRE 1322
Query: 461 -NESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQS 519
+ +K R+R + R E+ ++RE ++ R+R R S +RD +D++
Sbjct: 1323 WDRDADKDWPRNRDRDRLR----ERERERERDKRRDLDRERERLISDSVERDRDRDRDRT 1378
Query: 520 DKHDRRRSQSIEQESQEKQHKNKDET 545
+ + S + E +H+ E+
Sbjct: 1379 FESSQIESVKRCEAKLEGEHERDLES 1404
Score = 56.6 bits (135), Expect = 6e-08
Identities = 65/265 (24%), Positives = 107/265 (40%), Gaps = 17/265 (6%)
Query: 272 SPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSR 331
SPR S++R + D + +RQ ++ E ++R E S R+
Sbjct: 64 SPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSS-------PVRKES 116
Query: 332 SRERHRSRSR---SRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERER-SRE 387
SR RHR + +++R + + + E E + D +YD E +R++ RE
Sbjct: 117 SRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRE 176
Query: 388 RSK-EQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK 446
K EQ + + EE K++ R S +K S+S R+ +S S S+ K
Sbjct: 177 LMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
Query: 447 RSRSRSK--EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK 504
S S ++ K +K R+ S + + KK + K K + R K
Sbjct: 237 TSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYK---EKYKVKDRIEEK 293
Query: 505 ERSHKRDHSDSKDQSDKHDRRRSQS 529
R K D + Q +K D+ RS S
Sbjct: 294 TRDGKDRGRDFERQREKRDKPRSTS 318
Score = 31.2 bits (69), Expect = 2.5
Identities = 27/132 (20%), Positives = 53/132 (40%), Gaps = 5/132 (3%)
Query: 412 HRDDKRDSKKEKKHSRSRSR---ERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSN 468
H R + RS R + + R +++ ++ + R+ E+SS KE S
Sbjct: 61 HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVR--KESSR 118
Query: 469 KRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQ 528
R R + + E + E +R S + + ++ H S + + +R
Sbjct: 119 GRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELM 178
Query: 529 SIEQESQEKQHK 540
+EQE+ EK+ +
Sbjct: 179 KLEQENMEKREE 190
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 149 bits (375), Expect = 8e-36
Identities = 91/276 (32%), Positives = 149/276 (53%), Gaps = 19/276 (6%)
Query: 276 SRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRER 335
SR S R+ H ++ ++EKERQ +E+E +ERE+ER R R R ER R R RER
Sbjct: 278 SREISKFRDTHKKLEEEKG-KKEKERQEIEKERRERERERERERE-RRERERERERERER 335
Query: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
+ + R R+R+ D RDRDR +E++ +R R RDRD D+ER ++R K+R RSRE+S+++
Sbjct: 336 EKEKERERERERD-RDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDR--- 391
Query: 396 GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER-KHRSRSRSRNAGKRSRSRSKE 454
E++ + +++ R R+ +R+ ++E++ R R RER K + R R + R E
Sbjct: 392 ----EREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
Query: 455 KSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSD 514
+ + K + ++ K + +T EK +RE +E +++ R KE D+ D
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE--FLEDYDD 505
Query: 515 SKDQ------SDKHDRRRSQSIEQESQEKQHKNKDE 544
+D S R R + E E+ E+ K + E
Sbjct: 506 DRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE 541
Score = 141 bits (355), Expect = 2e-33
Identities = 93/345 (26%), Positives = 164/345 (47%), Gaps = 43/345 (12%)
Query: 225 VQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE 284
+ + I + T + ++ GK+ E + ERR R RR R R R RE
Sbjct: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERERE 336
Query: 285 GHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRD 344
++E ERE+ER R KER+++R R R DR ER R+++R RSR +SRD
Sbjct: 337 K------EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
Query: 345 RKGDR-RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ----------- 392
R+ +R R+R+RERE+E ER R R+R+ ++ER EREK+++R RE +E
Sbjct: 391 REREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKL 450
Query: 393 ----------------RSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR 436
R R + E + + ++++ R R+ +++K+ K+ +R
Sbjct: 451 REKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDP 510
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNK---RSRSGSQGRTDSVEKSKKREHSPS 493
R KR R R KE + ++ +EK R R ++G D + ++
Sbjct: 511 KYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQR------ 564
Query: 494 KEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQ 538
E+ +R R + + + + +++ + + +R + +E+E + +Q
Sbjct: 565 MEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
Score = 140 bits (352), Expect = 4e-33
Identities = 93/290 (32%), Positives = 153/290 (52%), Gaps = 39/290 (13%)
Query: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR-R 350
+RE ERE+ER+R ERE +ERE+ER R + +R ER R R R+R + R R RDR+ DR R
Sbjct: 311 ERERERERERERRERE-REREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDR 369
Query: 351 DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKE-QRSRGEVEEKKHKEDKDD 409
DR+R ++ +R R R++ D+ER ERE+ERER RER +E +R R E++ + +KD
Sbjct: 370 DRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDK 429
Query: 410 RRHRD-DKRDSKKEKKHSRS-RSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKE-- 465
+R R+ D+ D+ + +K R R +E ++ R ++ +R ++R EK ++ + E +
Sbjct: 430 KRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREM 489
Query: 466 -KSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSR---SKERSHKRDHSDSKD---- 517
K KR + + D + K S +++ R R + + ER KR+ + ++
Sbjct: 490 AKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQR 549
Query: 518 ---------------QSDKHDRRRSQSI---------EQESQEKQHKNKD 543
+ +RRR I E+E QEK+ K ++
Sbjct: 550 LLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599
Score = 82.0 bits (201), Expect = 1e-15
Identities = 95/398 (23%), Positives = 158/398 (39%), Gaps = 105/398 (26%)
Query: 234 KTRPRKIKKD-GKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFD 292
K R R+ ++D ++ +E DR +R R R R S R+ RSRSR R+ +
Sbjct: 339 KERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERE 398
Query: 293 RELEREKERQRLEREAKEREKERRRSRSID---------------RGLERRRSRSRERHR 337
RE ERE+ER+R +ERE+ER R R D R LER+ ++
Sbjct: 399 REREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQ 458
Query: 338 SRSRSRDRKGDRRDRDREREKENERGRRRD------------RDYDKERGN--------- 376
R ++ + + ++ R+ E+E E E RRR+ DYD +R +
Sbjct: 459 ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSAL 518
Query: 377 -----EREKERE---RSRERSKE---------------------QRSRGEVE-------- 399
+REKE E R R+R KE QR E E
Sbjct: 519 QKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIK 578
Query: 400 -------EKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS 452
E++ K++K+++R + + + E+K + + S S +G + +
Sbjct: 579 QEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTP 638
Query: 453 KEKSS-----KHKNESKEK-----------SNKRSRSGSQGRTDSVEKSK--------KR 488
++S H+N ++ S K S S G+ +SV++ K K
Sbjct: 639 GDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKF 698
Query: 489 EHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRR 526
E S + RKR + D + +K + ++R+
Sbjct: 699 EDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRK 736
Score = 52.0 bits (123), Expect = 1e-06
Identities = 46/204 (22%), Positives = 84/204 (41%), Gaps = 20/204 (9%)
Query: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD 414
+ E +E +RRD+ +G RE S E + + KK KE K+D R
Sbjct: 192 DEEALDEETKRRDQMI---KGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRF 248
Query: 415 D-----------KRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNES 463
K D + R + S+ R + K + K++ + + E
Sbjct: 249 PVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHK-KLEEEKGKKEKERQEIEK 307
Query: 464 KEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRK----RSRSKERSHKRDHSDSKDQS 519
+ + +R R + R + E+ ++RE KEK R+ R R ++R+ +RD +++
Sbjct: 308 ERRERERERERERERRER-EREREREREREKEKERERERERDRDRDRTKERDRDRDRERD 366
Query: 520 DKHDRRRSQSIEQESQEKQHKNKD 543
DR RS ++ + K++D
Sbjct: 367 RDRDRERSSDRNKDRSRSREKSRD 390
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 141 bits (356), Expect = 1e-33
Identities = 102/314 (32%), Positives = 154/314 (49%), Gaps = 21/314 (6%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
R + + K ++ R R RS + R+ S RS SRS S R+ GSSS
Sbjct: 328 RHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSS----- 382
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
KE R + + ++++ RSRS ++ +R RSRS + R RSRSR RD R
Sbjct: 383 -PRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRS-PNKARDCSRS 440
Query: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDD 415
R R R R R +K R + R + ++R+RS RSR +E+ H + + RD
Sbjct: 441 RSPYKARDRSRSRSPNKARDHSRSRSPNKARDRS---RSRSPSKERDHSQLGSPSKERDH 497
Query: 416 KRDSKKEK----KHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRS 471
+R K + SRS S+ER HR RSR+ K + R +K ++ S+ +S
Sbjct: 498 RRSRSPSKERQCRQSRSSSKERDHR---RSRSPSKERQRRQSRSPNKERDRSQSRSPSEE 554
Query: 472 RSGSQGRTDSVEKSKKREHSPSKEKSRKRSR--SKERSHKRDHSDSKDQSDKHDRRRSQS 529
R Q R+ S E+ ++R SPSKE+ R++SR S+ER H R S +K + R R+ S
Sbjct: 555 REHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG--YSRPRASS 612
Query: 530 IEQESQEKQHKNKD 543
E+ + +K+
Sbjct: 613 KEKAHSRSRTPSKE 626
Score = 132 bits (333), Expect = 6e-31
Identities = 108/327 (33%), Positives = 159/327 (48%), Gaps = 51/327 (15%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQR------LEREAKE 310
R R +S +S SPRRS S+ R+H R S S+ R R + R R + R ++
Sbjct: 275 RSRPQSHSQSRSPRRSRSGSQKRTHSRVR--SHSWKRNHSRARSRTRKGILSQMGRHSQS 332
Query: 311 REKERRRSRSIDRGLERRRSR------SRERHRSRSRSRDRKGDRRDRDREREKENERGR 364
R + +S++ R R RS S+ER S SRS ++ D R R+ E GR
Sbjct: 333 RSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRK---ESGR 389
Query: 365 RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKK 424
+ +K+R + R + ++R+RS RSR + + + + RD R K
Sbjct: 390 SQSGSPNKQRDHSRSRSPNKARDRS---RSRSPYKARDRSRSRSPNKARDCSRSRSPYKA 446
Query: 425 HSRSRSRE-RKHRSRSRSRNAGK---RSRSRSKEKSSKHK---NESKEKSNKRSRSGS-- 475
RSRSR K R SRSR+ K RSRSRS K H + SKE+ ++RSRS S
Sbjct: 447 RDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKE 506
Query: 476 ----QGRTDSVEKSKKREHSPSKEKSRKRSRS--------------KERSHKRDHSDSKD 517
Q R+ S E+ +R SPSKE+ R++SRS +ER H++ S SK+
Sbjct: 507 RQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKE 566
Query: 518 QSDKHDRRRSQSIEQESQEKQHKNKDE 544
+ DRRR +S +E + +Q ++ E
Sbjct: 567 R----DRRRWRSPSKERERRQSRSSSE 589
Score = 130 bits (328), Expect = 2e-30
Identities = 98/317 (30%), Positives = 161/317 (50%), Gaps = 20/317 (6%)
Query: 227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286
K D + + PRK + G+ R R RS + R S RSP ++R RS R +
Sbjct: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
Query: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR----S 342
+ R K R R + + ++ RSRS ++ +R RSRS + R S+ S
Sbjct: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPS 492
Query: 343 RDRKGDR-RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ---RSRGEV 398
++R R R +ER+ R ++RD+ + R +E++R +SR +KE+ +SR
Sbjct: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPS 552
Query: 399 EEKKHKEDKDDRRHRDDKR----DSKKEKKHSRSRSRERKH-RSRSRSRNAG-KRSRSRS 452
EE++H++ + + RD +R ++E++ SRS S ER H RSRS ++ +G R R+ S
Sbjct: 553 EEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASS 612
Query: 453 KEKS-SKHKNESKEKSNKRSRSGSQGRTDS---VEKSKKREHSPSKEK--SRKRSRSKER 506
KEK+ S+ + SKE ++ +SR+ S+ S V +S + SP++ S+ R+ SK
Sbjct: 613 KEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672
Query: 507 SHKRDHSDSKDQSDKHD 523
SH S Q+ D
Sbjct: 673 SHSPSTFPSGGQTLSQD 689
Score = 124 bits (311), Expect = 2e-28
Identities = 103/319 (32%), Positives = 148/319 (46%), Gaps = 40/319 (12%)
Query: 263 PRRSLSPRRSPRRSR-----------SRSHHREGHGSSSFDRELEREKERQRLEREAKER 311
P + S SP SR SR SS + + R R + ++ R
Sbjct: 226 PSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSR 285
Query: 312 EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG---------DRRDRDREREKENER 362
R RS S R R RS S +R+ SR+RSR RKG R + + + R
Sbjct: 286 SPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSR 345
Query: 363 GRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK---EDKDDRRHRDDKRDS 419
RR R ++ R +E+ SR SKE+ RG +K + + RD R
Sbjct: 346 TPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSR 405
Query: 420 KKEKKHSRSRSRER-KHRSRSRSRNAGKR---SRSRSKEKS-----SKHKNESKEKSNKR 470
K RSRSR K R RSRSR+ K SRSRS K+ S+ N++++ S R
Sbjct: 406 SPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSR 465
Query: 471 SRSGSQGRTDSVEKSKKREHS----PSKEKSRKRSR--SKERSHKRDHSDSKDQSDKHDR 524
S + ++ R+ S SK+R+HS PSKE+ +RSR SKER ++ S SK++ H R
Sbjct: 466 SPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERD--HRR 523
Query: 525 RRSQSIEQESQEKQHKNKD 543
RS S E++ ++ + NK+
Sbjct: 524 SRSPSKERQRRQSRSPNKE 542
Score = 119 bits (299), Expect = 5e-27
Identities = 90/292 (30%), Positives = 143/292 (48%), Gaps = 35/292 (11%)
Query: 259 RSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR-- 316
+ R R S SPR+ RS+S S +++ S S R++ R R +A++R + R
Sbjct: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
Query: 317 ------RSRSIDRGLERRRSRS----RERHRSRSRSRDRKGDRRDRDREREKENERGRRR 366
RSRS + +R RSRS R+ RSRS ++ RDR R R E
Sbjct: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK-----ARDRSRSRSPSKE----- 482
Query: 367 DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS 426
RD+ + +E++ RSR SKE++ R + + +++D RR R KE++
Sbjct: 483 -RDHSQLGSPSKERDHRRSRSPSKERQCR---QSRSSSKERDHRR----SRSPSKERQRR 534
Query: 427 RSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSK 486
+SRS K R RS+SR+ + R SK ++ + +S + R Q R+ S E+
Sbjct: 535 QSRS-PNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDH 593
Query: 487 KREHSPSKEK--SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQE 536
R SP+K+ SR R+ SKE++H R + SK+ H + R+ S E + +
Sbjct: 594 SRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKE--GNHSQSRTSSKESDPSQ 643
Score = 113 bits (283), Expect = 4e-25
Identities = 95/285 (33%), Positives = 143/285 (50%), Gaps = 33/285 (11%)
Query: 256 ERRRSRSPR------RSLSPRRSPRRSRSRS------HHREGHGSSSFDRELER----EK 299
+R RSRSP RS SP ++ RSRSRS H R + + DR R E+
Sbjct: 424 DRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKER 483
Query: 300 ERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR---DRER 356
+ +L +KER+ R RS S +R + RS S+ER RSRS ++ RR ++ER
Sbjct: 484 DHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKER 543
Query: 357 EKENERGRRRDRDYDKERGNEREKERERSRERSKE---QRSRGEVEEKKHKEDKDDRRHR 413
++ R +R++ + R +E++R R R SKE ++SR EE+ H + +
Sbjct: 544 DRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQS 603
Query: 414 --DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRS 471
R S KEK HSRSR+ K + S+SR + K S +S+ ++ ++S R+
Sbjct: 604 GYSRPRASSKEKAHSRSRT-PSKEGNHSQSRTSSKES---DPSQSTVPRSPDWKRSPTRT 659
Query: 472 RSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516
S SQ RT SK HSPS S ++ S++ S + D + SK
Sbjct: 660 SSLSQNRT----PSKTSSHSPSTFPSGGQTLSQDDS-QADATTSK 699
Score = 85.5 bits (210), Expect = 1e-16
Identities = 96/374 (25%), Positives = 154/374 (41%), Gaps = 56/374 (14%)
Query: 220 RIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSR 279
R P V + ++ ++ + G R RR SRS +RS S +P R R+
Sbjct: 89 RTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRT- 147
Query: 280 SHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRR---------S 330
H G +S R +++ R + + R R RS S R L ++
Sbjct: 148 --HGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIG 205
Query: 331 RSRERHRSRSRSR---------DRKGDRRDRDREREKENERGRR----RDRDYDKERGNE 377
RS E + S ++ K D R K G+ R++ Y +
Sbjct: 206 RSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR-KVKSYGQMIIPSREKSYSPTEMSS 264
Query: 378 REKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERK--- 434
R K ++ RS+ Q ++ + R H + S K + HSR+RSR RK
Sbjct: 265 RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWK-RNHSRARSRTRKGIL 323
Query: 435 ----HRSRSRSRNAGK-RSRSRSKEKSSKH---KNESKEKSNKRSRSGSQ---------- 476
S+SRS + GK +++SR+ + H +N SKE+S+ SRS S+
Sbjct: 324 SQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSP 383
Query: 477 ----GRTDSVEKSKKREHS----PSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQ 528
GR+ S +K+R+HS P+K + R RSRS ++ R S S +++ R RS
Sbjct: 384 RKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSP 443
Query: 529 SIEQESQEKQHKNK 542
++ + NK
Sbjct: 444 YKARDRSRSRSPNK 457
Score = 81.6 bits (200), Expect = 2e-15
Identities = 79/326 (24%), Positives = 136/326 (41%), Gaps = 46/326 (14%)
Query: 235 TRPRKIKKDGKE--GAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGS-SSF 291
++PR + K G I R E + S + +P P + +S + S+
Sbjct: 186 SQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSY 245
Query: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD 351
+ + +E+ E R K ++ + RSR + +SRS R R G ++
Sbjct: 246 GQMIIPSREKSYSPTEMSSRVKSYNQAST--------RSRPQSHSQSRSPRRSRSGSQK- 296
Query: 352 RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRR 411
R R R + +R + R + R R S+ R + + H + K +
Sbjct: 297 ----------RTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHS---QSRSHSKGKSQNQ 343
Query: 412 HRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGKRSRSRSKEKS--------SKHKNE 462
R +R + SR+ S+ER H SRS S+ R S +++S +K ++
Sbjct: 344 SRTPRRG--RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDH 401
Query: 463 SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE----------KSRKRSRSKERSHKRDH 512
S+ +S ++R S+ R+ + + R SP+K K+R RSRS+ + RDH
Sbjct: 402 SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDH 461
Query: 513 SDSKDQSDKHDRRRSQSIEQESQEKQ 538
S S+ + DR RS+S +E Q
Sbjct: 462 SRSRSPNKARDRSRSRSPSKERDHSQ 487
Score = 51.6 bits (122), Expect = 2e-06
Identities = 63/249 (25%), Positives = 101/249 (40%), Gaps = 26/249 (10%)
Query: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERG--RRRDRDYDKERG 375
S+S +R +R RSR RS+ R R D K ++ R R RG
Sbjct: 62 SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
Query: 376 NEREKERERSRERSKEQRSR-GEVEEKKHKEDKDDR-RHRDDKRDSKKEKKHSRSRSRER 433
+ RS +RS + S G + + R R ++ + K + R R+ R
Sbjct: 122 RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
Query: 434 KHRSRSRSRNAGKRSR--------SRSKEKSSKHKN---------ESKEKSNKRSRSGS- 475
+ RS S+ RN K+S RS E + SKEKS+ S S S
Sbjct: 182 E-RSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
Query: 476 --QGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQE 533
+ + S+++ +SP++ SR +S ++ + R S S+ +S + R SQ
Sbjct: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQK-RTH 299
Query: 534 SQEKQHKNK 542
S+ + H K
Sbjct: 300 SRVRSHSWK 308
Score = 32.0 bits (71), Expect = 1.5
Identities = 28/116 (24%), Positives = 45/116 (38%), Gaps = 1/116 (0%)
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
D K + + S + +R + SRN+ S KS+ K + + RSR
Sbjct: 25 DPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRV 84
Query: 474 GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQS 529
S+ RT S + R SK S R + +H R + + S R S++
Sbjct: 85 RSKARTPSRVSTDTRTSKASK-ASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRA 139
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 141 bits (355), Expect = 2e-33
Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 21/270 (7%)
Query: 253 RHVERRRSRSPRRSLSPR---RSP--RRSRSRSHHREGHGSSSFDRELEREKERQRLER- 306
R + RSRS RS S + RSP +SRSRSH S S D+ E+ + + +
Sbjct: 227 RSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKP 286
Query: 307 ----EAKEREKERRRSRSIDRGLE--------RRRSRSRERHRSRSRSRDRKGDR-RDRD 353
++ + K + RSRS +R +E R RS+ + +SRSRSR + G R R R
Sbjct: 287 KSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRS 346
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
R + K+ +GR+R R+ + R R K ERSR+R ++ S+ +KK KED D + R
Sbjct: 347 RSKSKDKRKGRKRSREESRSRSRSRSKS-ERSRKRGSKRDSKAGSSKKKKKEDTDRSQSR 405
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
R KE++H++S S +R+ R S + + +RSRS+ +SK K +S RS+S
Sbjct: 406 SPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSR-SNSKSKPNLPSESRSRSKS 464
Query: 474 GSQGRTDSVEKSKKREHSPSKEKSRKRSRS 503
S+ R+ S +S+ SPS+ +SR SRS
Sbjct: 465 ASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494
Score = 140 bits (352), Expect = 4e-33
Identities = 105/322 (32%), Positives = 144/322 (44%), Gaps = 23/322 (7%)
Query: 241 KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE 300
K DG E R VE + RRS S RS RSRSRS H S S + K
Sbjct: 159 KLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS 218
Query: 301 RQRLEREAKEREKERRRSRSIDRGL-ERRRSRSRERHRSRSRSRDRKGDRRDRDREREKE 359
R R ++ R K R RS+S R E+ RS S+E+ RSRS S + + E + +
Sbjct: 219 RSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQ 278
Query: 360 NERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE-----------DKD 408
N + + R + K R RS+ER E+ RG V + +E K
Sbjct: 279 NNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKG 338
Query: 409 DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSN 468
R R R K+K+ R RSRE RSRSRSR+ +RSR R ++ SK + K+K
Sbjct: 339 GSRSRSRSRSKSKDKRKGRKRSREES-RSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKE 397
Query: 469 KRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKE--------RSHKRDHSDSKDQSD 520
RS Q R+ S SK+REH+ S+ R+ E RS R +S SK
Sbjct: 398 DTDRS--QSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLP 455
Query: 521 KHDRRRSQSIEQESQEKQHKNK 542
R RS+S + + +++
Sbjct: 456 SESRSRSKSASKTRSRSKSRSR 477
Score = 122 bits (306), Expect = 8e-28
Identities = 73/229 (31%), Positives = 119/229 (51%), Gaps = 9/229 (3%)
Query: 324 GLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERE 383
G RRRS SR R SRSRSR R R+ R R ++ + R R R + + R
Sbjct: 178 GSRRRRSYSRSRSHSRSRSRSRHS-RKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRS 236
Query: 384 RSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS-------RSRSRERKHR 436
+SR RSK+++SR +EK + R +D +EK + +SRS R H+
Sbjct: 237 QSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR-HK 295
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
S+S+SR+ + R +++ S + S+EKS ++SRS S+ + S +S+ R S K K
Sbjct: 296 SKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK 355
Query: 497 SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
RKRSR + RS R S S+ + +R S++ + ++K+ ++ ++
Sbjct: 356 GRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQS 404
Score = 115 bits (289), Expect = 8e-26
Identities = 89/302 (29%), Positives = 143/302 (47%), Gaps = 34/302 (11%)
Query: 243 DGKEGAEEID-RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKER 301
D K E++D V R+ R RR SRSRSH R + R
Sbjct: 152 DMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSH--------------SRSRSR 197
Query: 302 QRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENE 361
R R+++ R + S S +SRSR R SRSRS+ R + ++EK
Sbjct: 198 SRHSRKSRSRSGSSKSSHS--------KSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS 249
Query: 362 RGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK---KHKEDKDDRRHRDDKRD 418
+ + R G R K ++++ E+ + + G+ + + +HK K R R +R
Sbjct: 250 PSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHK-SKSKSRSRSQERR 308
Query: 419 SKKEKKHSRSRSRE-----RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
++EK+ S SR R R+ RSRSRS+ G RSRSRS+ K SK K + +++S + SRS
Sbjct: 309 VEEEKRGSVSRGRSQEKSLRQSRSRSRSK-GGSRSRSRSRSK-SKDKRKGRKRSREESRS 366
Query: 474 GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQE 533
S+ R+ S K+ SK S K+ + ++ + S S+ S + + +S+S ++E
Sbjct: 367 RSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQRE 426
Query: 534 SQ 535
+
Sbjct: 427 GR 428
Score = 109 bits (273), Expect = 6e-24
Identities = 80/251 (31%), Positives = 124/251 (49%), Gaps = 21/251 (8%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
+ R KD E + + +V + +SRSP R S +S RS+ R E GS S R
Sbjct: 264 KSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQ 323
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
E+ + R +K + R RSRS + + R RSRE RSRSRSR +
Sbjct: 324 EKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSK---------- 373
Query: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDD 415
+ER R+R D + G+ ++K++E + SR +E++H + + +R
Sbjct: 374 ----SERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRG 429
Query: 416 KRDSKKEKKHSRSRSRERKHRSRSRSR-NAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474
+ ++ + +RSRS RS S+S+ N SRSRSK +SK ++ SK +S SRS
Sbjct: 430 ESENAGTNQETRSRS-----RSNSKSKPNLPSESRSRSK-SASKTRSRSKSRSRSASRSP 483
Query: 475 SQGRTDSVEKS 485
S+ R+ S +S
Sbjct: 484 SRSRSRSHSRS 494
Score = 95.5 bits (236), Expect = 1e-19
Identities = 59/195 (30%), Positives = 105/195 (53%), Gaps = 12/195 (6%)
Query: 359 ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRD 418
E++ G RR R Y + R + R + R R S++ RSR + H + + R R
Sbjct: 174 EDKPGSRRRRSYSRSRSHSRSRSRSR---HSRKSRSRSGSSKSSHSKSRSRSRSGSRSRS 230
Query: 419 SKKEKKHSRSRSRERKHRS------RSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSR 472
+ + SRSRS++ K RS RSRS +AGK SRS+SK+++ + + +SR
Sbjct: 231 KSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGK-SRSKSKDQAEEKIQNNDNVGKPKSR 289
Query: 473 SGSQGRTDSVEKSKKREHSPSKEK--SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSI 530
S S+ ++ S +S+ +E +EK S R RS+E+S ++ S S+ + R RS+S
Sbjct: 290 SPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSK 349
Query: 531 EQESQEKQHKNKDET 545
++ ++ + ++++E+
Sbjct: 350 SKDKRKGRKRSREES 364
Score = 86.3 bits (212), Expect = 7e-17
Identities = 80/255 (31%), Positives = 125/255 (49%), Gaps = 27/255 (10%)
Query: 305 EREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGR 364
ER E + RR S G R + R RD+ G + EN R
Sbjct: 63 ERVIVEHARGPRRDGSYGSG--------RSGYGYRRSGRDKYGPPTRTEYRLIVENLSSR 114
Query: 365 ---RRDRDYDKERGNEREKERERSRERSK--EQRSRGEVEEKKHKEDKDDRRHR-----D 414
+ +DY ++ G + + R+ E S +++ K D + R +
Sbjct: 115 CSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVE 174
Query: 415 DKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS-KEKSSKHKNESKEKSNKRSRS 473
DK S++ + +SRSRS R SRSRSR++ ++SRSRS KSS K+ S+ +S RSRS
Sbjct: 175 DKPGSRRRRSYSRSRSHSR---SRSRSRHS-RKSRSRSGSSKSSHSKSRSRSRSGSRSRS 230
Query: 474 GSQGRTDSVEKSKK-REHSPSKEKSRKRSRS--KERSHKRDHSDSKDQ-SDKHDRRRSQS 529
S+ R+ S +SKK + SPSKEKSR RS S K RS +D ++ K Q +D + +S+S
Sbjct: 231 KSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRS 290
Query: 530 IEQESQEKQHKNKDE 544
+ + + +++ +
Sbjct: 291 PSRHKSKSKSRSRSQ 305
Score = 70.1 bits (170), Expect = 5e-12
Identities = 66/226 (29%), Positives = 95/226 (42%), Gaps = 36/226 (15%)
Query: 228 NIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHG 287
N+ + P + K K + +R VE + S R S +S R+SRSRS + G
Sbjct: 282 NVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSR 341
Query: 288 SSSFDRELEREKE--RQRLEREAKEREKERRRS-RSIDRGLERR---------------R 329
S S R ++K R+R E++ R + R +S RS RG +R R
Sbjct: 342 SRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDR 401
Query: 330 SRSRERHRSRSRSRDR-KGDRRDRDREREKE----NERGRRRDRDYDKERGNEREKERER 384
S+SR RS S+ R+ K + R+ E E N+ R R R K + N + R R
Sbjct: 402 SQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSR 461
Query: 385 SRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS 430
S+ SK RSR + R R R + + S SRS
Sbjct: 462 SKSASK-TRSRSK------------SRSRSASRSPSRSRSRSHSRS 494
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 130 bits (327), Expect = 3e-30
Identities = 108/381 (28%), Positives = 170/381 (44%), Gaps = 58/381 (15%)
Query: 215 STLFPRIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHV----------ERR------ 258
ST+ P P+ +N K+ P+ +K+ K E +R +RR
Sbjct: 270 STVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRS 329
Query: 259 ----RSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR------------------ELE 296
+ R PRR +P RS R R R H R EL
Sbjct: 330 GRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELN 389
Query: 297 REKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRD--RKGDRRDRDR 354
KE QR KER+ R+ S + + + + H+S S+ RD R ++ D+ +
Sbjct: 390 EIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYK 449
Query: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG-EVEEKKHKEDKDDRRHR 413
+ K+ + + R + +K + ER+ + R+ E+ RS+G + E K KE + D + +
Sbjct: 450 NKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGK 509
Query: 414 DDKRDSKKEK-KHSRSRSRERKHRSRSRSRNAGKRSRSRSKE---KSSKHKNESKEKSNK 469
D +R KEK K S+S E H S+S+ +R++SRS+E KH S+ +
Sbjct: 510 DQERSRSKEKSKQLESKSNEHDH---SKSKEKDRRAQSRSRECDITKGKHSYNSRTRERS 566
Query: 470 RSRSGS---QGRTDSVEKSKKREHSPSKE---KSRKRSRSKERSHKRDHSDSKDQSDKHD 523
RSR S + RT ++S+ +E+ +E + R RSRS+ER S SKD+
Sbjct: 567 RSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRR---- 622
Query: 524 RRRSQSIEQESQEKQHKNKDE 544
RRR S E +E Q +NKD+
Sbjct: 623 RRRRDSRSSEREESQSRNKDK 643
Score = 123 bits (309), Expect = 4e-28
Identities = 92/346 (26%), Positives = 163/346 (47%), Gaps = 36/346 (10%)
Query: 224 PVQKNIDQQIKTRPRKI---KKDGKEGAEEIDRHVER--RRSRSPRRSLSPRRSPRRSRS 278
P +KN +++ K + K ++D + +E+ D++ + +R++S RS S +S + R
Sbjct: 416 PNRKN-EKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERD 474
Query: 279 RSHHREGHG---SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRER 335
H+R S S R+ E KE+++ + ++K +++ER RS+ + LE S+S E
Sbjct: 475 SKHNRNEEKRMRSRSKGRDHENVKEKEK-QSDSKGKDQERSRSKEKSKQLE---SKSNEH 530
Query: 336 HRSRSRSRDRKGDRRDRD--------------REREKENERGRR-RDRDYDKERGNEREK 380
S+S+ +DR+ R R+ RER + +R RR R R +D++R R K
Sbjct: 531 DHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRS--RSK 588
Query: 381 ERERSRERSKEQRSRGEVEEKK----HKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR 436
E R RE+ +R R E++ KD RR R D R S++E+ SR++ + R
Sbjct: 589 EYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQE 648
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
S+S R S R KS H + + + K R Q +++S + S
Sbjct: 649 SKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADR--DQSPFSKIKQSSQDNELKSSML 706
Query: 497 SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
K S ++++ SK Q + H +++ + ES ++K
Sbjct: 707 KNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752
Score = 121 bits (303), Expect = 2e-27
Identities = 91/332 (27%), Positives = 160/332 (48%), Gaps = 30/332 (9%)
Query: 225 VQKNIDQQIKTRPRKIKKDGKEGAE--EIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHH 282
+Q+ ++ + R IK D E E E R R + R + SP R +
Sbjct: 366 MQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKK 425
Query: 283 REGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS 342
+ H S+S +R++ R E+ + K + K ++R++S +SRS+ + +S+S+
Sbjct: 426 VKDHKSNSKERDIRRNSEK-----DDKYKNKVKKRAKS--------KSRSKSKEKSKSKE 472
Query: 343 RDRKGDRRDRDREREKENERGRRRDRDYDKERGNE-REKERERSRERSKEQRSRGEVEEK 401
RD K +R + R R + R ++ +K+ ++ +++ER RS+E+SK+ S+ +
Sbjct: 473 RDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDH 532
Query: 402 KHKEDKDDRRHRDDKRDSKKEKKHS-------RSRSRERKHRSRSRSRNAGKRSRSRSKE 454
++KD R + + KHS RSRSR+R R RSR+ + R RSRSKE
Sbjct: 533 SKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHD---RDRSRSKE 589
Query: 455 KSSKHKNESKEKSNKRSRS--GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKE--RSHKR 510
+ E + + RSR GR+ S ++ ++R S S E+ +SR+K+ R+ +
Sbjct: 590 YHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQES 649
Query: 511 DHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
S K+ S+ R S+S + S + K
Sbjct: 650 KSSHRKENSESEKRMYSKSRDHNSSNNSREKK 681
Score = 119 bits (298), Expect = 7e-27
Identities = 90/350 (25%), Positives = 172/350 (49%), Gaps = 40/350 (11%)
Query: 225 VQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSH--- 281
+++N ++ + RKI D + +E +R E+ + +S S R RR+ +
Sbjct: 391 IKENQRSPVRVKERKIT-DHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYK 449
Query: 282 HREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRR---------SRS 332
++ + S R +EK + + ER++K E +R RS +G + S+
Sbjct: 450 NKVKKRAKSKSRSKSKEKSKSK-ERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKG 508
Query: 333 RERHRSRSRSRDRKGDRRDRDREREKENERGRR---RDRDYDKERG----NEREKERERS 385
+++ RSRS+ + ++ + + + + K E+ RR R R+ D +G N R +ER RS
Sbjct: 509 KDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRS 568
Query: 386 RERSKEQRSRGEVEEKK-----HKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
R+RS+ RSR ++ H+ + + R R R ++ RSRS++R+ R R
Sbjct: 569 RDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDS 628
Query: 441 SRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP---SKEKS 497
+ + S+SR+K+ K++N+ + S+++ S S+ R SK R+H+ S+EK
Sbjct: 629 RSSEREESQSRNKD---KYRNQESKSSHRKENSESEKRM----YSKSRDHNSSNNSREKK 681
Query: 498 RKRSRSKERSHKRDHSDSKDQS----DKHDRRRSQSIEQESQEKQHKNKD 543
R +S K+ D++ +S +K D + S+E+E+Q+ + + D
Sbjct: 682 ADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQEND 731
Score = 114 bits (286), Expect = 2e-25
Identities = 100/352 (28%), Positives = 170/352 (48%), Gaps = 49/352 (13%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRS-----------PRRSLSPRRSPRRSRS 278
+++ K R +K +K+ ++ +E + + ++S S P+ ++ P P +
Sbjct: 224 EEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPEN 283
Query: 279 RSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRS 338
R R+ + RE+ER+R + +R + R + + R R+R+
Sbjct: 284 RFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRT 343
Query: 339 RSRSRDRKGDRRDRDREREKENERGRRRDRDYDKER---GNERE----KERERSRERSKE 391
SRSR R RR ++ + +R R ER G++ E KE +RS R KE
Sbjct: 344 PSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKE 403
Query: 392 QR-----------SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
++ +R +EKK K+ K + + RD +R+S+K+ K+ + K +SRS+
Sbjct: 404 RKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSK 463
Query: 441 SRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR 500
S + +S+SKE+ SKH N ++E KR RS S+GR D +K + S SK K ++R
Sbjct: 464 S-----KEKSKSKERDSKH-NRNEE---KRMRSRSKGR-DHENVKEKEKQSDSKGKDQER 513
Query: 501 SRSKE-------RSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
SRSKE +S++ DHS SK +K R +S+S E + + +H T
Sbjct: 514 SRSKEKSKQLESKSNEHDHSKSK---EKDRRAQSRSRECDITKGKHSYNSRT 562
Score = 106 bits (265), Expect = 5e-23
Identities = 94/310 (30%), Positives = 141/310 (45%), Gaps = 38/310 (12%)
Query: 239 KIKKDGKEGAEEIDRHVERRRSRSPRR-SLSPRRSPRRSRSRSHHREGHG---------S 288
K K K+ A+ R + +S+S R S R +R RSRS R+ S
Sbjct: 447 KYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDS 506
Query: 289 SSFDRELEREKERQR-LEREAKE------REKERR---RSRSID--RGLERRRSRSRERH 336
D+E R KE+ + LE ++ E +EK+RR RSR D +G SR+RER
Sbjct: 507 KGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERS 566
Query: 337 RSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERER--SRERSKEQR- 393
RSR RSR + DRDR R KE R R+++Y + RG R +ER R RSK++R
Sbjct: 567 RSRDRSRRVRSRTHDRDRSRSKEYHR--YREQEY-RRRGRSRSRERRTPPGRSRSKDRRR 623
Query: 394 ----SRGEVEEKKHKEDKDDRRHRDDKRDSKKE------KKHSRSRSRERKHRSRSRSRN 443
SR E+ +KD R+++ K +KE + +S+SR + SR + +
Sbjct: 624 RRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKAD 683
Query: 444 AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRS 503
+ S+ K+ S ++ +S NK +KSK +E+ EK++K
Sbjct: 684 RDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHE 743
Query: 504 KERSHKRDHS 513
D S
Sbjct: 744 SSPGTDEDKS 753
Score = 95.5 bits (236), Expect = 1e-19
Identities = 96/369 (26%), Positives = 164/369 (44%), Gaps = 76/369 (20%)
Query: 239 KIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELERE 298
K+KK+ K+ RH + S S S S S S+S S + S++ ++ +R+
Sbjct: 182 KVKKEEKK------RH---KSSSSSSSSSSDSDSSSDSQSSSDSSDSE-SATEEKSKKRK 231
Query: 299 KERQRLEREAKEREKERRRSR---SIDRGLERRRSRSRE-----------RHRSRSRSRD 344
K+ ++ R+ K+ +K+R++S+ S + E ++ + +R R
Sbjct: 232 KKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSP 291
Query: 345 RKGDRRDR-DREREKENE--------------------------RGRRRDRDYDKERGNE 377
K D ++R +RERE+E E RG RR R + R +
Sbjct: 292 PKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRD 351
Query: 378 REKERER----SRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK---KEKK------ 424
R + E +E + QR R E+ K DK + + + S KE+K
Sbjct: 352 RFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRN 411
Query: 425 --HSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSV 482
S +R E++ + + N+ +R R+ EK K+KN+ K+++ +SRS S+ ++ S
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471
Query: 483 EKSKKREHSPSKEKSRKRSRSKERSH-------KRDHSDSKDQSDKHDRRRSQSIEQESQ 535
E+ K H+ ++EK R RSRSK R H K+ S KDQ + +S+ +E +S
Sbjct: 472 ERDSK--HNRNEEK-RMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSN 528
Query: 536 EKQHKNKDE 544
E H E
Sbjct: 529 EHDHSKSKE 537
Score = 53.1 bits (126), Expect = 6e-07
Identities = 56/266 (21%), Positives = 101/266 (37%), Gaps = 32/266 (12%)
Query: 282 HREGH----GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHR 337
H +GH G +E+ RE E Q+ + +K + R S + + ++RH+
Sbjct: 133 HLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHK 192
Query: 338 SRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGE 397
S S S D D D + ++ + E+SK+++ +
Sbjct: 193 SSSSSSSSSSDS-----------------DSSSDSQSSSDSSDSESATEEKSKKRKKKHR 235
Query: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSS 457
+KHK++K R K+ K S + + E + +S R +R + S
Sbjct: 236 KNSRKHKKEKKKR-----KKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKS 290
Query: 458 KHKNESKEKSNK-RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516
K + KE+ N+ R R +S S +R ++ + + R R S S+
Sbjct: 291 PPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSR 350
Query: 517 DQSDKHDRRRSQSIEQESQEKQHKNK 542
D+ RRS++ QE Q +
Sbjct: 351 DRF-----RRSETPPHWRQEMQRAQR 371
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 129 bits (324), Expect = 7e-30
Identities = 79/263 (30%), Positives = 141/263 (53%), Gaps = 31/263 (11%)
Query: 264 RRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDR 323
R L + SPR H++ G DR+ ER++ R++ E KER+++R+R R R
Sbjct: 51 RGRLGSQESPRSWGLGQAHKDADGD---DRQRERDRVREKTE---KERDRDRKRDRE-RR 103
Query: 324 GLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERE 383
E+ +R+R+R + RDR+ R++ + RE+E +RGR R+RD D+E+ ER+ E++
Sbjct: 104 RKEKETNRNRDREKQTEIERDRE---REKQKGRERERDRGRERERDRDREKERERQTEKD 160
Query: 384 RSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRN 443
R +R E + E +K KE ++ R RD +RD++KE++ R R+R+ ++++
Sbjct: 161 RDGQRETETERERDREREKQKE-RETERDRDRQRDTEKERERQTDRERDRQRKTQT---- 215
Query: 444 AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRS 503
+R R +E E+ R R + R E+ ++R+ ++K RK+ R
Sbjct: 216 --ERQRETDRE---------GERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERK 264
Query: 504 KERSHKRDHSDSKDQSDKHDRRR 526
KER K+ K++ + D++R
Sbjct: 265 KERKEKK-----KEEKRREDKKR 282
Score = 125 bits (314), Expect = 1e-28
Identities = 78/231 (33%), Positives = 119/231 (51%), Gaps = 28/231 (12%)
Query: 248 AEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLERE 307
A+ DR ER R R R R R +E + + +++ E E++R+R +++
Sbjct: 72 ADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQK 131
Query: 308 AKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR-----RDRDREREKENER 362
+ERE++ RG ER R R RE+ R R +DR G R R+RDREREK+ ER
Sbjct: 132 GRERERD--------RGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKER 183
Query: 363 GRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE---DKDDRRHRDDKRDS 419
RDR D++R E+E+ER+ RER ++++++ E + + +E + D RR R RD
Sbjct: 184 ETERDR--DRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDR 241
Query: 420 KKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKR 470
KE+ R R ERK +R + R KE+ K K E + + KR
Sbjct: 242 GKERDRERDRKEERKK----------ERKKERKKERKEKKKEEKRREDKKR 282
Score = 116 bits (290), Expect = 6e-26
Identities = 73/225 (32%), Positives = 119/225 (52%), Gaps = 13/225 (5%)
Query: 227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286
K+ D + R R ++ E + DR +R R R + + R+ R + R+
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKET---NRNRDREKQTEIERDRE 126
Query: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRK 346
RE ER++ R+R ER+ ++REKER R DR +R RER R R + ++R+
Sbjct: 127 REKQKGRERERDRGRER-ERD-RDREKERERQTEKDRDGQRETETERERDREREKQKERE 184
Query: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406
+ RDRDR+R+ E ER R+ DR+ D++R + E++RE RE +E R ++ + D
Sbjct: 185 TE-RDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRR-----RERQRD 238
Query: 407 KDDRRHRDDKRDSKKEKKHSR--SRSRERKHRSRSRSRNAGKRSR 449
+D + RD +RD K+E+K R R +ERK + + R K+ +
Sbjct: 239 RDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRK 283
Score = 85.9 bits (211), Expect = 9e-17
Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 8/165 (4%)
Query: 234 KTRPRKIKKD-GKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFD 292
K + R+ ++D G+E + DR ER R R R R R ++ + D
Sbjct: 129 KQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERD 188
Query: 293 RELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR 352
R+ +R+ E++R + +ER+++R+ R +R R +R R R R RDR G RDR
Sbjct: 189 RDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDR-GKERDR 247
Query: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGE 397
+R+R++E ++ R+ KER ER+++++ + R ++R GE
Sbjct: 248 ERDRKEERKKERK------KERKKERKEKKKEEKRREDKKRKWGE 286
Score = 77.4 bits (189), Expect = 3e-14
Identities = 51/204 (25%), Positives = 99/204 (48%), Gaps = 28/204 (13%)
Query: 352 RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRR 411
R R +E+ R + + G++R++ER+R RE+++++R D+D +R
Sbjct: 51 RGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKER------------DRDRKR 98
Query: 412 HRDDKRDSKKEKKHSRSRSRER-----------KHRSRSRSRNAGK-RSRSRSKEKSSKH 459
R+ +R KEK+ +R+R RE+ K + R R R+ G+ R R R +EK +
Sbjct: 99 DRERRR---KEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERER 155
Query: 460 KNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQS 519
+ E K++ +R + R EK K+RE +++ R + +ER R+ +
Sbjct: 156 QTE-KDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQ 214
Query: 520 DKHDRRRSQSIEQESQEKQHKNKD 543
+ R + E+E+ ++ + +D
Sbjct: 215 TERQRETDREGERETDRRRERQRD 238
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 129 bits (323), Expect = 9e-30
Identities = 69/204 (33%), Positives = 113/204 (55%), Gaps = 13/204 (6%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
R R+ K++ G E ER R R R R R R R HRE DR+
Sbjct: 3 RQRERKRETDRGKE-----TERERDRQRERENQTERE-NRHRQRDRHRER------DRQT 50
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR-RDRDR 354
+REKER+R + ++R++ER R +R ER+R R R+R R R +DR +R R+ DR
Sbjct: 51 DREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDR 110
Query: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD 414
RE+ + GR RD+ ++ER ERE++R+R RER +++ + E + ++ + + + R ++
Sbjct: 111 NRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKE 170
Query: 415 DKRDSKKEKKHSRSRSRERKHRSR 438
K++ KKE+K + + R+ + R
Sbjct: 171 RKKERKKERKEKKKEEKRREDKKR 194
Score = 125 bits (314), Expect = 1e-28
Identities = 70/203 (34%), Positives = 112/203 (55%), Gaps = 12/203 (5%)
Query: 277 RSRSHHREGHGSSSFDRELEREKERQ-RLEREAKEREKERRRSRSIDRGLERRRSRSRER 335
R R RE +RE +R++ER+ + ERE + R+++R R R DR +R + R R++
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRER--DRQTDREKERERQK 60
Query: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
R R R R+R+ +R+ ER++E +R R R R D+ER +R++ER+R +R++E+ +
Sbjct: 61 ERDRQRQRERE---TERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRK 117
Query: 396 GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEK 455
G E DK R RD +R+ +++++ R R RERK R R R R KE+
Sbjct: 118 GGRE-----RDKQTERERDRERERQRQRERERQRQRERK-RETDRERQRWAEREERKKER 171
Query: 456 SSKHKNESKEKSNKRSRSGSQGR 478
+ K E KEK + R + R
Sbjct: 172 KKERKKERKEKKKEEKRREDKKR 194
Score = 121 bits (303), Expect = 2e-27
Identities = 68/194 (35%), Positives = 113/194 (58%), Gaps = 5/194 (2%)
Query: 234 KTRPRKIKKD-GKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGS--SS 290
+ R RK + D GKE E DR ER +++ R + +R R R R RE
Sbjct: 3 RQRERKRETDRGKETERERDRQRERE-NQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR- 349
DR+ +RE+E +R +ER+++R R R DR ++ R R R+R R+R R+RKG R
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 350 RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDD 409
RD+ ERE++ ER R+R R+ +++R ER++E +R R+R E+ R + +K+ K+++ +
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181
Query: 410 RRHRDDKRDSKKEK 423
++ + +R+ KK K
Sbjct: 182 KKKEEKRREDKKRK 195
Score = 118 bits (296), Expect = 1e-26
Identities = 66/201 (32%), Positives = 109/201 (54%), Gaps = 11/201 (5%)
Query: 312 EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYD 371
E++R R R DRG E R R R+R R R+ + +RDR RER+++ +R + R+R +
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 372 KERGNEREKERERSRERSKE-QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS 430
++R +RE+E ER ER +E QR R + + DKD R R+ KR++ + ++ +R
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKD--RDRERKRETDRNRERNRKGG 119
Query: 431 RER-KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKRE 489
RER K R R R +R R R +E+ + + E K ++++ Q + E+ K+R+
Sbjct: 120 RERDKQTERERDR---ERERQRQRERERQRQRERKRETDRE----RQRWAEREERKKERK 172
Query: 490 HSPSKEKSRKRSRSKERSHKR 510
KE+ K+ K R K+
Sbjct: 173 KERKKERKEKKKEEKRREDKK 193
Score = 114 bits (286), Expect = 2e-25
Identities = 65/200 (32%), Positives = 113/200 (56%), Gaps = 14/200 (7%)
Query: 334 ERHRSRSRSRDR-KGDRRDRDREREKENE-----RGRRRDRDYDKERGNEREKERERSRE 387
ER R R R DR K R+RDR+RE+EN+ R R+RDR +++R +REKERER +E
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 388 RSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERK-HRSRSRSRNAGK 446
R + QR R E++ + ++ +R R+ KR + +E+ R R R+R+ R+R R+R G+
Sbjct: 62 RDR-QRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGR 120
Query: 447 RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKER 506
+++ + + + +++ +R R + R E+ + E ++K RK+ R KER
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAERE-ERKKERKKERKKER 179
Query: 507 SHKRDHSDSKDQSDKHDRRR 526
K+ K++ + D++R
Sbjct: 180 KEKK-----KEEKRREDKKR 194
Score = 103 bits (257), Expect = 4e-22
Identities = 58/204 (28%), Positives = 115/204 (56%), Gaps = 20/204 (9%)
Query: 341 RSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEE 400
R R+RK R+ DR +E E ER R+R+R+ ER N R ++R+R RER + Q R + E
Sbjct: 3 RQRERK---RETDRGKETERERDRQRERENQTEREN-RHRQRDRHRERDR-QTDREKERE 57
Query: 401 KKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK 460
++ + D+ +R R+ +R+++++++ R R R+R + R R K++ + K
Sbjct: 58 RQKERDRQRQRERETERETERQRERQRQRERKR------------QTDRERDKDRDRERK 105
Query: 461 NESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSD 520
E+ +++ +R+R G + R E+ + RE +++ R+R R +ER KR+ + +
Sbjct: 106 RET-DRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRER--KRETDRERQRWA 162
Query: 521 KHDRRRSQSIEQESQEKQHKNKDE 544
+ + R+ + ++ +E++ K K+E
Sbjct: 163 EREERKKERKKERKKERKEKKKEE 186
Score = 94.4 bits (233), Expect = 2e-19
Identities = 62/180 (34%), Positives = 96/180 (53%), Gaps = 15/180 (8%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
Q + + + R R ++D + E+ +R ++ R R +R R R R R RE
Sbjct: 30 QTERENRHRQRDRHRERDRQTDREK-ERERQKERDRQRQRERETERETERQRERQRQRER 88
Query: 286 HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR 345
+ DRE +++++R+R + RE+ R+ R D+ ER R R RER R R R R R
Sbjct: 89 KRQT--DRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQR 146
Query: 346 KGDR-RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404
+ +R R+ DRER++ ER R+ KER ER+KER +E+ KE++ R E+KK K
Sbjct: 147 QRERKRETDRERQRWAEREERK-----KERKKERKKER---KEKKKEEKRR---EDKKRK 195
Score = 51.2 bits (121), Expect = 2e-06
Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
Q+ +++ +T + K +E E DR+ ER R R R R R R RE
Sbjct: 83 QRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRER 142
Query: 286 HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR 345
+R+ E ++ERQR ERE ER++ R +R ER+ + E+ R + +
Sbjct: 143 ERQRQRERKRETDRERQRWA----ERE-ERKKERKKERKKERKEKKKEEKRREDKKRKWG 197
Query: 346 KG 347
+G
Sbjct: 198 EG 199
Score = 35.8 bits (81), Expect = 0.10
Identities = 19/81 (23%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 465 EKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDR 524
E+ +R R +G+ E+ ++RE E+ R R ++R +RD Q+D+
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTEREN-RHRQRDRHRERDR-----QTDREKE 55
Query: 525 RRSQSIEQESQEKQHKNKDET 545
R Q ++++ + + ET
Sbjct: 56 RERQKERDRQRQRERETERET 76
>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 129 bits (323), Expect = 9e-30
Identities = 90/263 (34%), Positives = 145/263 (55%), Gaps = 19/263 (7%)
Query: 260 SRSPRRSLSPRRSPRRSRSRSHHREGHGSSS--FDRELEREKERQRLEREAKEREKERRR 317
SR+ RS SP+R R SRSRS + S S + R ++ E R R+ K R++ R
Sbjct: 543 SRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARV----KIRDRRRSN 598
Query: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK---ENERGRRRDRDYDKER 374
SI+R R RS SRER RSRSRSRDR+ +R R R R++ +++RG + K +
Sbjct: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH-KHK 657
Query: 375 GNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERK 434
G +E+ER++ R RS ++ + + +E++ ++DK + + +++D K + R + +
Sbjct: 658 GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRES 717
Query: 435 HRSRSRSRNAGKR-----SRSRSKEKSSK-HKNESKEKSNKRSRSGSQGRTDSVEKSKKR 488
R+ SRS + + SR SK+ ++K K S S+ RS S S G + +K+KK
Sbjct: 718 ERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPG-SSKEKKAKKP 776
Query: 489 EHSPSK--EKSRKRSRSKERSHK 509
+HS S+ EKS++ + R HK
Sbjct: 777 KHSRSRSVEKSQRSGKKASRKHK 799
Score = 112 bits (281), Expect = 7e-25
Identities = 96/342 (28%), Positives = 147/342 (42%), Gaps = 52/342 (15%)
Query: 248 AEEIDRHVERRRSRSPRRS---LSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQ-- 302
A E D V + R+P + L P++ + + R G SS R
Sbjct: 471 AREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSST 530
Query: 303 -------------RLEREAKEREKERRRSRSIDRGLERRRSRSR--------ERHRSRSR 341
R + ++++R SRS ++ RRSRSR E +R+R +
Sbjct: 531 VSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVK 590
Query: 342 SRDRKGDRR---DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEV 398
RDR+ R +R+R R + R RRR R ++R R R RSR+R K RG +
Sbjct: 591 IRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRAS-RSRSRDRRKIDDQRGNL 649
Query: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR-SRSRSKEKSS 457
HK H+ + ++ +++K+ SRS ++RK + + R R KR + + +EK
Sbjct: 650 SGNSHK-------HKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDF 702
Query: 458 KHKNESKEKSNKR------SRSGSQG----RTDSVEKSKKREHSPSKEKSRKRSRSKERS 507
K ++ KR SRSGS R DS + SKK SK+ S S + S
Sbjct: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762
Query: 508 HKRDHS-DSKDQSDKHDRRRSQSIEQESQEK---QHKNKDET 545
S + K + KH R RS Q S +K +HK+K +
Sbjct: 763 ESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
Score = 90.1 bits (222), Expect = 5e-18
Identities = 76/255 (29%), Positives = 117/255 (45%), Gaps = 19/255 (7%)
Query: 224 PVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHR 283
P K + ++ R+IK + +I R R RS R S+ R RR+RS S R
Sbjct: 564 PTIKARRSRSRSYSRRIKIESNRARVKI-----RDRRRSNRNSIERER--RRNRSPSRER 616
Query: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
S S DR R R R K ++ S + + + + R++ RSRS +
Sbjct: 617 RRSRSRSRDRRTNR-ASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDK 675
Query: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH 403
DRK ++R+RE++K E+ +R ++D+ ++R K R+R ER+ + V+ +H
Sbjct: 676 DRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLK-RKRESERTFSRSGSISVKIIRH 734
Query: 404 KEDKDDRRHRDDKRDSKKEKKHSRS-----RSRERKHRSRSRSRNAGKRSRSRSKEKSSK 458
D R K +K KKHS S S E S+ + K SRSRS EKS +
Sbjct: 735 -----DSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQR 789
Query: 459 HKNESKEKSNKRSRS 473
++ K +SRS
Sbjct: 790 SGKKASRKHKSKSRS 804
Score = 80.9 bits (198), Expect = 3e-15
Identities = 70/267 (26%), Positives = 117/267 (43%), Gaps = 12/267 (4%)
Query: 283 REGHGSSSFDRELEREKERQRLEREA---KEREKERRRSRSIDRGLERRRSRSRERHRSR 339
R GS S D + E + R R ++EA KE+E++ + ++ ++ ++E +
Sbjct: 400 RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFI 459
Query: 340 SRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS-RERSKEQRSRGEV 398
+ ++ R+ + + NE+ R + + KE+E+ R RS S
Sbjct: 460 HKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSS 519
Query: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR-SRSRSRNAGKRSRSRSKEKSS 457
+ S + SRS S +RK R SRSRS K RSRS+ S
Sbjct: 520 SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI-KARRSRSRSYSR 578
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
+ K ES ++ + R + +S+E+ ++R SPS+E+ R RSRS++R R
Sbjct: 579 RIKIESN-RARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNR-----AS 632
Query: 518 QSDKHDRRRSQSIEQESQEKQHKNKDE 544
+S DRR+ HK+K E
Sbjct: 633 RSRSRDRRKIDDQRGNLSGNSHKHKGE 659
Score = 60.5 bits (145), Expect = 4e-09
Identities = 92/414 (22%), Positives = 158/414 (38%), Gaps = 92/414 (22%)
Query: 221 IPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRH----VERRRSRSPRRSLSPR------ 270
I +PV++ Q + R + +EG E+++R +E+ R R LS +
Sbjct: 213 IALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATE 272
Query: 271 --------RSPRRSRSRSHHRE-------GHGSSSFDRELEREKERQRLEREAKEREKER 315
R P+RS+ S E S R + + + E E EKE
Sbjct: 273 DAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEY 332
Query: 316 RRSRS---------IDRGLERRRSRSRERHRSRSRSRDRK----------------GDRR 350
+ +D E +++ HR +++ ++ G
Sbjct: 333 QMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG 392
Query: 351 DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ----------------RS 394
D E E+ + D D ++ R R+K+ E + KEQ R
Sbjct: 393 SGDSEDERSDRGSESSDTDDEELRHRIRQKQ-EAFWRKEKEQQLLHDKQMEEEKQQTERV 451
Query: 395 RGEVEEKKHKEDKD----DRRHRDDKRDSKKEKKHSRSRS----------RERKHRSRSR 440
E+ E HKE + R D ++K++ + + S +E++ RSRS
Sbjct: 452 TKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG 511
Query: 441 SRNAG-KRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRK 499
S ++G S SR+ SS + S S+ SR+ S+ + +K R SP+ + R
Sbjct: 512 SSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRS 571
Query: 500 RSRSKERSHK----------RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
RSRS R K RD S S + +RRR++S +E + + +++D
Sbjct: 572 RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
sapiens]
Length = 805
Score = 129 bits (323), Expect = 9e-30
Identities = 90/263 (34%), Positives = 145/263 (55%), Gaps = 19/263 (7%)
Query: 260 SRSPRRSLSPRRSPRRSRSRSHHREGHGSSS--FDRELEREKERQRLEREAKEREKERRR 317
SR+ RS SP+R R SRSRS + S S + R ++ E R R+ K R++ R
Sbjct: 543 SRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARV----KIRDRRRSN 598
Query: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK---ENERGRRRDRDYDKER 374
SI+R R RS SRER RSRSRSRDR+ +R R R R++ +++RG + K +
Sbjct: 599 RNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSH-KHK 657
Query: 375 GNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERK 434
G +E+ER++ R RS ++ + + +E++ ++DK + + +++D K + R + +
Sbjct: 658 GEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRES 717
Query: 435 HRSRSRSRNAGKR-----SRSRSKEKSSK-HKNESKEKSNKRSRSGSQGRTDSVEKSKKR 488
R+ SRS + + SR SK+ ++K K S S+ RS S S G + +K+KK
Sbjct: 718 ERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPG-SSKEKKAKKP 776
Query: 489 EHSPSK--EKSRKRSRSKERSHK 509
+HS S+ EKS++ + R HK
Sbjct: 777 KHSRSRSVEKSQRSGKKASRKHK 799
Score = 112 bits (281), Expect = 7e-25
Identities = 96/342 (28%), Positives = 147/342 (42%), Gaps = 52/342 (15%)
Query: 248 AEEIDRHVERRRSRSPRRS---LSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQ-- 302
A E D V + R+P + L P++ + + R G SS R
Sbjct: 471 AREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSST 530
Query: 303 -------------RLEREAKEREKERRRSRSIDRGLERRRSRSR--------ERHRSRSR 341
R + ++++R SRS ++ RRSRSR E +R+R +
Sbjct: 531 VSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVK 590
Query: 342 SRDRKGDRR---DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEV 398
RDR+ R +R+R R + R RRR R ++R R R RSR+R K RG +
Sbjct: 591 IRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRAS-RSRSRDRRKIDDQRGNL 649
Query: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR-SRSRSKEKSS 457
HK H+ + ++ +++K+ SRS ++RK + + R R KR + + +EK
Sbjct: 650 SGNSHK-------HKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDF 702
Query: 458 KHKNESKEKSNKR------SRSGSQG----RTDSVEKSKKREHSPSKEKSRKRSRSKERS 507
K ++ KR SRSGS R DS + SKK SK+ S S + S
Sbjct: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762
Query: 508 HKRDHS-DSKDQSDKHDRRRSQSIEQESQEK---QHKNKDET 545
S + K + KH R RS Q S +K +HK+K +
Sbjct: 763 ESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804
Score = 90.1 bits (222), Expect = 5e-18
Identities = 76/255 (29%), Positives = 117/255 (45%), Gaps = 19/255 (7%)
Query: 224 PVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHR 283
P K + ++ R+IK + +I R R RS R S+ R RR+RS S R
Sbjct: 564 PTIKARRSRSRSYSRRIKIESNRARVKI-----RDRRRSNRNSIERER--RRNRSPSRER 616
Query: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
S S DR R R R K ++ S + + + + R++ RSRS +
Sbjct: 617 RRSRSRSRDRRTNR-ASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDK 675
Query: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH 403
DRK ++R+RE++K E+ +R ++D+ ++R K R+R ER+ + V+ +H
Sbjct: 676 DRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLK-RKRESERTFSRSGSISVKIIRH 734
Query: 404 KEDKDDRRHRDDKRDSKKEKKHSRS-----RSRERKHRSRSRSRNAGKRSRSRSKEKSSK 458
D R K +K KKHS S S E S+ + K SRSRS EKS +
Sbjct: 735 -----DSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQR 789
Query: 459 HKNESKEKSNKRSRS 473
++ K +SRS
Sbjct: 790 SGKKASRKHKSKSRS 804
Score = 80.9 bits (198), Expect = 3e-15
Identities = 70/267 (26%), Positives = 117/267 (43%), Gaps = 12/267 (4%)
Query: 283 REGHGSSSFDRELEREKERQRLEREA---KEREKERRRSRSIDRGLERRRSRSRERHRSR 339
R GS S D + E + R R ++EA KE+E++ + ++ ++ ++E +
Sbjct: 400 RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFI 459
Query: 340 SRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS-RERSKEQRSRGEV 398
+ ++ R+ + + NE+ R + + KE+E+ R RS S
Sbjct: 460 HKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSS 519
Query: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR-SRSRSRNAGKRSRSRSKEKSS 457
+ S + SRS S +RK R SRSRS K RSRS+ S
Sbjct: 520 SNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTI-KARRSRSRSYSR 578
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
+ K ES ++ + R + +S+E+ ++R SPS+E+ R RSRS++R R
Sbjct: 579 RIKIESN-RARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNR-----AS 632
Query: 518 QSDKHDRRRSQSIEQESQEKQHKNKDE 544
+S DRR+ HK+K E
Sbjct: 633 RSRSRDRRKIDDQRGNLSGNSHKHKGE 659
Score = 60.5 bits (145), Expect = 4e-09
Identities = 92/414 (22%), Positives = 158/414 (38%), Gaps = 92/414 (22%)
Query: 221 IPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRH----VERRRSRSPRRSLSPR------ 270
I +PV++ Q + R + +EG E+++R +E+ R R LS +
Sbjct: 213 IALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATE 272
Query: 271 --------RSPRRSRSRSHHRE-------GHGSSSFDRELEREKERQRLEREAKEREKER 315
R P+RS+ S E S R + + + E E EKE
Sbjct: 273 DAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEY 332
Query: 316 RRSRS---------IDRGLERRRSRSRERHRSRSRSRDRK----------------GDRR 350
+ +D E +++ HR +++ ++ G
Sbjct: 333 QMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG 392
Query: 351 DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ----------------RS 394
D E E+ + D D ++ R R+K+ E + KEQ R
Sbjct: 393 SGDSEDERSDRGSESSDTDDEELRHRIRQKQ-EAFWRKEKEQQLLHDKQMEEEKQQTERV 451
Query: 395 RGEVEEKKHKEDKD----DRRHRDDKRDSKKEKKHSRSRS----------RERKHRSRSR 440
E+ E HKE + R D ++K++ + + S +E++ RSRS
Sbjct: 452 TKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSG 511
Query: 441 SRNAG-KRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRK 499
S ++G S SR+ SS + S S+ SR+ S+ + +K R SP+ + R
Sbjct: 512 SSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRS 571
Query: 500 RSRSKERSHK----------RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
RSRS R K RD S S + +RRR++S +E + + +++D
Sbjct: 572 RSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRD 625
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 127 bits (318), Expect = 3e-29
Identities = 74/219 (33%), Positives = 120/219 (54%), Gaps = 8/219 (3%)
Query: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLER-RRSRSRERHRSRSRSRDRKGDR-RDR 352
+E + E + E + +++R R R DR +R + S++ +RH R R RDR+ +R RDR
Sbjct: 1 MESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDR 60
Query: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRH 412
DREREK+ +R R R+ +++R +RE ERER +ER ++ + + E +K KE ++ R
Sbjct: 61 DREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKE-REMERV 119
Query: 413 RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSR 472
RD +R+ +KE R RE R R R A +R R +E+ ++ ++ +E+ KR R
Sbjct: 120 RDREREKQKEMGRERQTDRE---TDRERERQA-ERERETGRERKTEDRHRERERERKRER 175
Query: 473 SGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRD 511
+ T E+ E +E RKR R +E +RD
Sbjct: 176 ERKR-ETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 117 bits (292), Expect = 4e-26
Identities = 65/218 (29%), Positives = 115/218 (52%), Gaps = 8/218 (3%)
Query: 310 EREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRD 369
E + E R + + ++R+R R RE R R R+++ K + R +R+R+++ ER R RDRD
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRD 61
Query: 370 YDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDK-RDSKKEKKHSRS 428
++E+ +RE ER+R RER ++++ E E ++ KE + DR D+ R +KE++ R
Sbjct: 62 REREKQTDREGERQRERERDRDRQR--ETERERDKERETDRHTETDRERQKQKEREMERV 119
Query: 429 RSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKR 488
R RER+ + R R +E+ ++ + E+ + R + R E+ +KR
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 489 EHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRR 526
E K R+R ER +R+ +D+ + +R R
Sbjct: 180 E-----TKERERHTDMERERQRETDRKRDRQRESERER 212
Score = 117 bits (292), Expect = 4e-26
Identities = 67/215 (31%), Positives = 114/215 (53%), Gaps = 17/215 (7%)
Query: 249 EEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREA 308
E +DR ERRR R + + S++ H E DR+ +RE+ R+R
Sbjct: 15 ETMDRQRERRRETDRERDRA-----KESKTEDRHSER------DRQRDRERNRER----D 59
Query: 309 KEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRR-DRDREREKENERGRRRD 367
++RE+E++ R +R ER R R R+R R R ++R+ DR + DRER+K+ ER R
Sbjct: 60 RDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERV 119
Query: 368 RDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR 427
RD ++E+ E +ER+ RE +E+ + E E + +E K + RHR+ +R+ K+E++ R
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 428 SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNE 462
+H R R + R R +++ S+ + +
Sbjct: 180 ETKERERHTDMERERQR-ETDRKRDRQRESERERD 213
Score = 98.6 bits (244), Expect = 1e-20
Identities = 55/212 (25%), Positives = 111/212 (52%), Gaps = 9/212 (4%)
Query: 330 SRSRERH-RSRSRSRDRKGDRR---DRDREREKENERGRRRDRDYDKERGNEREKERERS 385
S++ RH + + + DR+ +RR DR+R+R KE+ + DR +++R +RE+ RER
Sbjct: 3 SKTEGRHTHTETETMDRQRERRRETDRERDRAKES---KTEDRHSERDRQRDRERNRERD 59
Query: 386 RERSKEQRSRGEVEEKKHKE-DKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNA 444
R+R +E+++ E E ++ +E D+D +R + +RD ++E RER+ +
Sbjct: 60 RDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERV 119
Query: 445 GKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK 504
R R + KE + + + + + ++ + T K++ R +E+ R+R R +
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 505 ERSHKRDHSD-SKDQSDKHDRRRSQSIEQESQ 535
E + H+D +++ + DR+R + E E +
Sbjct: 180 ETKERERHTDMERERQRETDRKRDRQRESERE 211
Score = 97.8 bits (242), Expect = 2e-20
Identities = 61/194 (31%), Positives = 98/194 (50%), Gaps = 17/194 (8%)
Query: 231 QQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSS 290
++ KT R ++D + DR R R R R R R R R R+ +
Sbjct: 35 KESKTEDRHSERDRQR-----DRERNRERDRDREREKQTDREGERQRERERDRDRQRETE 89
Query: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRR 350
+R+ ERE +R ++++KER E R R RER + + R+R+ DR
Sbjct: 90 RERDKERETDRHTETDRERQKQKER----------EMERVRDREREKQKEMGRERQTDRE 139
Query: 351 -DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDD 409
DR+RER+ E ER R+R ++R ERE+ER+R RER +E + R + + + ++
Sbjct: 140 TDRERERQAERERETGRERK-TEDRHRERERERKRERERKRETKERERHTDMERERQRET 198
Query: 410 RRHRDDKRDSKKEK 423
R RD +R+S++E+
Sbjct: 199 DRKRDRQRESERER 212
Score = 74.7 bits (182), Expect = 2e-13
Identities = 44/172 (25%), Positives = 88/172 (51%), Gaps = 9/172 (5%)
Query: 377 EREKERERSRERSKEQRSRGEVEEKKHKED--KDDRRHRDDKRDSKKEKKHSRSRSRER- 433
+R++ER R +R +++ + E++ + D +D R+R+ RD ++EK+ R R+R
Sbjct: 18 DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRE 77
Query: 434 KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKK--REHS 491
+ R R R R +R R + +E + +H +E+ ++ R + R EK K+ RE
Sbjct: 78 RERDRDRQRET-ERERDKERE-TDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQ 135
Query: 492 PSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
+E R+R R ER +R+ + D+H R + + ++++ K ++
Sbjct: 136 TDRETDRERERQAER--ERETGRERKTEDRHRERERERKRERERKRETKERE 185
Score = 72.8 bits (177), Expect = 8e-13
Identities = 43/137 (31%), Positives = 72/137 (52%), Gaps = 3/137 (2%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
+++ D+Q +T + K+ + E DR ++++ R R R ++ R +
Sbjct: 79 ERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDR 138
Query: 286 HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR 345
+R+ ERE+E R ER+ ++R +ER R R +R +R ++ RERH R R R
Sbjct: 139 ETDRERERQAERERETGR-ERKTEDRHRERERERKRERE-RKRETKERERHTDMERERQR 196
Query: 346 KGDRRDRDREREKENER 362
+ DR+ RDR+RE E ER
Sbjct: 197 ETDRK-RDRQRESERER 212
Score = 72.0 bits (175), Expect = 1e-12
Identities = 43/173 (24%), Positives = 82/173 (47%), Gaps = 17/173 (9%)
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
+R ER +E +R R+R+KE ++ E+ + D++ R RD R+ +K+ R RE
Sbjct: 18 DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRE 77
Query: 433 RKHRSRSRSRNAGKRSRSRSKEKSS-KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHS 491
R+ R R R R R R KE+ + +H +E+ ++ R +E+ + RE
Sbjct: 78 RE-RDRDRQRET---ERERDKERETDRHTETDRERQKQKERE--------MERVRDRE-- 123
Query: 492 PSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
+EK ++ R ++ + D + + + R + E +E++ + K E
Sbjct: 124 --REKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRE 174
Score = 65.9 bits (159), Expect = 9e-11
Identities = 39/169 (23%), Positives = 85/169 (50%), Gaps = 10/169 (5%)
Query: 385 SRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS-RSRSRER-KHRSRSRSR 442
S+ + + E +++ + ++ R RD ++SK E +HS R R R+R ++R R R R
Sbjct: 3 SKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDR 62
Query: 443 NAGKRS-----RSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS 497
K++ R R +E+ + E++ + +K + TD E+ K++E + +
Sbjct: 63 EREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDR-ERQKQKEREMERVRD 121
Query: 498 RKRSRSKE--RSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
R+R + KE R + D +++ + +R R E++++++ + + E
Sbjct: 122 REREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERE 170
Score = 62.8 bits (151), Expect = 8e-10
Identities = 34/127 (26%), Positives = 63/127 (49%), Gaps = 2/127 (1%)
Query: 418 DSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQG 477
+SK E +H+ + + E R R R R R R R+KE ++ ++ +++ R R+ +
Sbjct: 2 ESKTEGRHTHTET-ETMDRQRERRRET-DRERDRAKESKTEDRHSERDRQRDRERNRERD 59
Query: 478 RTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEK 537
R EK RE +E+ R R R +E +RD D+ + DR R + E+E +
Sbjct: 60 RDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERV 119
Query: 538 QHKNKDE 544
+ + +++
Sbjct: 120 RDREREK 126
Score = 60.8 bits (146), Expect = 3e-09
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 2/120 (1%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE- 284
++ D+ +T + K+ +E DR E+++ R R R RE
Sbjct: 95 ERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERET 154
Query: 285 GHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRD 344
G + DR ERE+ER+R ERE K KER R ++R +R R R+R R R RD
Sbjct: 155 GRERKTEDRHRERERERKR-ERERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213
>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
sapiens]
Length = 434
Score = 124 bits (311), Expect = 2e-28
Identities = 78/250 (31%), Positives = 130/250 (52%), Gaps = 7/250 (2%)
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
+R+K++++ E R + SRS R ER+R E + RSRSR ++G R + +
Sbjct: 19 DRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDK 78
Query: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDD 415
K+++ D+++ ++G ER E +R K + + + +RRHR
Sbjct: 79 SSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSR 138
Query: 416 KRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGS 475
R E+K SRSRSRERK +SRSRSR K+SRSRS+E+ + ++ S+ +S R R+ S
Sbjct: 139 SR----ERKKSRSRSRERK-KSRSRSRER-KKSRSRSRERKRRIRSRSRSRSRHRHRTRS 192
Query: 476 QGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIE-QES 534
+ RT S + +K+ + SR SR+ R + + D + RR ++ + QE
Sbjct: 193 RSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQ 252
Query: 535 QEKQHKNKDE 544
+EK+ K +
Sbjct: 253 REKEMVEKQK 262
Score = 117 bits (294), Expect = 2e-26
Identities = 76/218 (34%), Positives = 122/218 (55%), Gaps = 20/218 (9%)
Query: 296 EREKERQRLEREAKEREKERRRSR-SID-RGLERRRSRSRERHRSRSRSRDRKGDRRDRD 353
+ E++ E+ + +R+K++ +S S+ R + SRSR R R R R D +G R+ R
Sbjct: 5 DTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEG-RKHRS 63
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
R R KE R +D+ K + +E ++E S ++ +E+ + E E +HK +
Sbjct: 64 RSRSKEGRRHESKDKSSKKHK-SEEHNDKEHSSDKGRERLNSSENGEDRHKRKE------ 116
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
R S + + HSRSRSRER+HRSRSR R K+SRSRS+E+ K+ S+ + K+SRS
Sbjct: 117 ---RKSSRGRSHSRSRSRERRHRSRSRER---KKSRSRSRERK---KSRSRSRERKKSRS 167
Query: 474 GSQGRTDSVE-KSKKREHSPSKEKSRKRSRSKERSHKR 510
S+ R + +S+ R + +SR R+RS+ R K+
Sbjct: 168 RSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKK 205
Score = 114 bits (284), Expect = 3e-25
Identities = 93/289 (32%), Positives = 126/289 (43%), Gaps = 46/289 (15%)
Query: 234 KTRPRKIKKDGKEGAEEIDR----HVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
KT P + KK + R H R RSRS R R+ RSRS +EG
Sbjct: 15 KTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHE 74
Query: 290 SFDRELEREKERQRLEREA---KEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRK 346
S D+ ++ K + ++E K RE+ DR + R SR R SRSRSR
Sbjct: 75 SKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSR--- 131
Query: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406
+RR R R RE++ R R R+R + R ER+K R RSRER + RSR
Sbjct: 132 -ERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSR----------- 179
Query: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS-SKHKNESKE 465
SRSRSR R HR+RSRSR RSRSR ++K K + S+
Sbjct: 180 -------------------SRSRSRHR-HRTRSRSRT---RSRSRDRKKRIEKPRRFSRS 216
Query: 466 KSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSD 514
S S +GR +++ + + K + R KE K+ +
Sbjct: 217 LSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQE 265
Score = 111 bits (278), Expect = 1e-24
Identities = 82/288 (28%), Positives = 129/288 (44%), Gaps = 26/288 (9%)
Query: 260 SRSPRRSLSPRR-SPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRS 318
S + R L+P + SP R + + + R + R R + + E + RS
Sbjct: 4 SDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRS 63
Query: 319 RSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNER 378
RS R E RR S+++ + +S + D+ RE+ N DR KER + R
Sbjct: 64 RS--RSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSR 121
Query: 379 EKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR 438
+ RSR R + RSR ++ K+ + R R R +E+K SRSRSRERK R R
Sbjct: 122 GRSHSRSRSRERRHRSRS----RERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIR 177
Query: 439 SRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR 498
SRS RSRSR + ++ +S R+RS S+ R +EK ++ S S+ S
Sbjct: 178 SRS-----RSRSRHRHRT---------RSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSP 223
Query: 499 KRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546
R + + D+++ + R + EQ +E K K + +
Sbjct: 224 PPFRGRNTA-----MDAQEALARRLERAKKLQEQREKEMVEKQKQQEI 266
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 122 bits (307), Expect = 6e-28
Identities = 74/215 (34%), Positives = 116/215 (53%), Gaps = 33/215 (15%)
Query: 293 RELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR 352
RE ER++ER+R + AKER +E+ R DR +R+R R R+R R R R R+R GDR DR
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDR-DR 116
Query: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRER----SKEQRSRGEVEEKKHKEDKD 408
+ E E++ ER R+RDR +REK+RER R+R K++ E + + +E +
Sbjct: 117 ETETERQEERERQRDR--------KREKDRERQRQREIGIDKDREIETEKDRDREREMGE 168
Query: 409 DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSN 468
R+RD +R+ +K+++ R R RER+ R KE + ++ KE+
Sbjct: 169 TERYRDRERERQKQRETRRDRDRERQ----------------REKEDRERDRDRQKEREK 212
Query: 469 KRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRS 503
R R GR ++ K+R+ +EK R R ++
Sbjct: 213 DRYRERETGR----DRDKERDRERQREKDRDRQKA 243
Score = 110 bits (274), Expect = 4e-24
Identities = 62/220 (28%), Positives = 113/220 (51%), Gaps = 9/220 (4%)
Query: 301 RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN 360
R + + ++R+ R + + R R R RER R R R+++R R++DRE EK+
Sbjct: 32 RLAMRSQIEDRDVLILRGSRVAPAIIRERERQRERERQRKRAKER---HREKDREIEKDR 88
Query: 361 ERGRRRDRDYDKERGNEREKERERSRERSKE---QRSRGEVEEKKHKEDKDDRRHRDDKR 417
+R R+RDR+ + R +R++ER R+R E Q R ++K ++D++ +R R+
Sbjct: 89 DRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGI 148
Query: 418 DSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQG 477
D +E + + R RER+ R R+ R R R K++ ++ + + + K R +
Sbjct: 149 DKDREIETEKDRDREREMGETERYRD---RERERQKQRETRRDRDRERQREKEDRERDRD 205
Query: 478 RTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
R EK + RE +++ ++R R ++R RD + D
Sbjct: 206 RQKEREKDRYRERETGRDRDKERDRERQREKDRDRQKAID 245
Score = 108 bits (269), Expect = 2e-23
Identities = 73/211 (34%), Positives = 112/211 (53%), Gaps = 23/211 (10%)
Query: 222 PVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSH 281
P +++ Q+ + R RK KE E DR +E+ R R +R R +R R R
Sbjct: 54 PAIIRERERQRERERQRK---RAKERHREKDREIEKDRDRQRKRD----RERQRWRDRDR 106
Query: 282 HREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR 341
RE G + E ER++ER+R +E+++ER+R R I G+++ R E + R R
Sbjct: 107 KRERWGDRDRETETERQEERERQRDRKREKDRERQRQREI--GIDK--DREIETEKDRDR 162
Query: 342 SRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKE-RERSRERSKEQRSRGEVEE 400
R+ R RDRERE++ +R RRDRD R +REKE RER R+R KE+ E
Sbjct: 163 EREMGETERYRDRERERQKQRETRRDRD----RERQREKEDRERDRDRQKER-------E 211
Query: 401 KKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR 431
K +++ R RD +RD +++++ R R +
Sbjct: 212 KDRYRERETGRDRDKERDRERQREKDRDRQK 242
Score = 107 bits (267), Expect = 3e-23
Identities = 77/240 (32%), Positives = 120/240 (50%), Gaps = 30/240 (12%)
Query: 209 TKLEWFSTLFPRI-PVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSL 267
T E FS L + PV + + QI+ R I + G A I R ER+R R +R
Sbjct: 14 TITESFSQLLLQTRPVSWRLAMRSQIEDRDVLILR-GSRVAPAIIRERERQRERERQRK- 71
Query: 268 SPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLER 327
R++ HRE DR+ +R+++R+R ++R++ER R + ER
Sbjct: 72 ---------RAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETER 122
Query: 328 RRSRSRERHRSRSRSRDRKGDR-------------RDRDREREK-ENERGRRRDRDYDKE 373
+ R R+R R R + R+R+ R +DRDRERE E ER R R+R+ K+
Sbjct: 123 QEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQ 182
Query: 374 RGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER 433
R R+++RER RE+ +R R +++ + +KD R R+ RD KE+ R R ++R
Sbjct: 183 RETRRDRDRERQREKEDRERDR----DRQKEREKDRYRERETGRDRDKERDRERQREKDR 238
Score = 94.4 bits (233), Expect = 2e-19
Identities = 50/186 (26%), Positives = 92/186 (49%), Gaps = 12/186 (6%)
Query: 350 RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSK---EQRSRGEVEEKKHKED 406
R+R RERE++ +R + R R+ D+E +R+++R+R RER + R R ++ + +
Sbjct: 60 RERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETE 119
Query: 407 KDDRRHRDDKRDSKKEKKHSRSRSRE---------RKHRSRSRSRNAGKRSRSRSKEKSS 457
+ + R+ +RD K+EK R R RE + R R R G+ R R +E+
Sbjct: 120 TERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERER 179
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
+ + E++ ++ + + R ++ K+RE +E+ R R KER +R +D
Sbjct: 180 QKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDRD 239
Query: 518 QSDKHD 523
+ D
Sbjct: 240 RQKAID 245
Score = 89.7 bits (221), Expect = 6e-18
Identities = 53/187 (28%), Positives = 92/187 (49%), Gaps = 6/187 (3%)
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
RERE++ ER R+R R ++ R +RE E++R R+R K R R ++ K ++ R R
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQR-KRDRERQRWRDRDRKRERWGDRDR 116
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAG-KRSRSRSKEKSSKHKNESKEKSNKRSR 472
+ + + ++E++ R R RE K R R R R G + R EK + E E R R
Sbjct: 117 ETETERQEERERQRDRKRE-KDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDR 175
Query: 473 SGSQGRTDSVEKSKKREHSPSK---EKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQS 529
+ + + + RE K E+ R R + +E+ R+ +D+ + DR R +
Sbjct: 176 ERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQRE 235
Query: 530 IEQESQE 536
+++ Q+
Sbjct: 236 KDRDRQK 242
Score = 79.7 bits (195), Expect = 6e-15
Identities = 47/173 (27%), Positives = 91/173 (52%), Gaps = 14/173 (8%)
Query: 374 RGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER 433
R ER++ERER R+R+KE R ++++ ++D+D +R RD +R +++ R R +R
Sbjct: 58 RERERQRERERQRKRAKE---RHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDR 114
Query: 434 KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREH--- 490
+ + + +R R R +EK +E+ +R + R EK + RE
Sbjct: 115 DRETETERQEERERQRDRKREK-------DRERQRQREIGIDKDREIETEKDRDREREMG 167
Query: 491 SPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
+ + R+R R K+R +RD D + Q +K DR R + ++E ++ +++ ++
Sbjct: 168 ETERYRDRERERQKQRETRRDR-DRERQREKEDRERDRDRQKEREKDRYRERE 219
Score = 43.1 bits (100), Expect = 6e-04
Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 16/113 (14%)
Query: 434 KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPS 493
+ R R R R +R R R+KE+ H+ + +E R R ++ + RE
Sbjct: 58 RERERQRER---ERQRKRAKER---HREKDREIEKDRDR----------QRKRDRERQRW 101
Query: 494 KEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546
+++ RKR R +R + + +++ + DR+R + E++ Q + +KD +
Sbjct: 102 RDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREI 154
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 122 bits (305), Expect = 1e-27
Identities = 68/202 (33%), Positives = 112/202 (55%), Gaps = 19/202 (9%)
Query: 305 EREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGR 364
+RE+ ER+KERR R R RER + R R R +K ++ + RER KE ER +
Sbjct: 31 QRES-ERKKERR----------EREKRKREREKERKRERGKKEKKKRKKRERGKERER-K 78
Query: 365 RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKK 424
R++R+ ++ E+E+ + + ++ +E++ RG E KK KE K+ R +R+ K++K+
Sbjct: 79 RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 425 HSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK 484
+ R +ERK R + GKR R R K K K + E K + N++ R + R + E+
Sbjct: 139 RKKKRRKERK-----REKERGKRERKRKKRK--KEEREKKRERNRKERKKERERKERRER 191
Query: 485 SKKREHSPSKEKSRKRSRSKER 506
K+R+ K+K RK+ R +R
Sbjct: 192 KKERKKERRKKKERKKDRKTDR 213
Score = 121 bits (304), Expect = 1e-27
Identities = 66/207 (31%), Positives = 113/207 (54%), Gaps = 18/207 (8%)
Query: 304 LEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERG 363
+ + +RE ER++ R R R RER + R R R +K ++ + RER KE ER
Sbjct: 25 ISKPCTQRESERKKER------REREKRKREREKERKRERGKKEKKKRKKRERGKERER- 77
Query: 364 RRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEK 423
+R++R+ ++ E+E+ + + ++ +E++ RG E KK KE K+ R +R+ K++K
Sbjct: 78 KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKK 137
Query: 424 KHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
+ + R +ERK R + GKR R R K K K + E K + N++ R + R + E
Sbjct: 138 RRKKKRRKERK-----REKERGKRERKRKKRK--KEEREKKRERNRKERKKERERKERRE 190
Query: 484 KSKKREHSPSKEKSRKRSRSKERSHKR 510
+ K+R+ KE+ +K+ R K+R R
Sbjct: 191 RKKERK----KERRKKKERKKDRKTDR 213
Score = 112 bits (281), Expect = 7e-25
Identities = 66/199 (33%), Positives = 107/199 (53%), Gaps = 8/199 (4%)
Query: 341 RSRDRKGDRRDRD-REREKENERGRRRDRDYDKER-GNEREKERERSR-ERSKEQRSRGE 397
R +RK +RR+R+ R+RE+E ER R R + K+R ER KERER R ER K+++ R E
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91
Query: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSS 457
E +K K++K R + R +K+KK + R RE K R R R R ++ + R + K
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQR-RERKRKKRRKKKRRKERKRE 150
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
K + + + K KR + + + + K +K+E + + RK+ R KER K++ +
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR- 209
Query: 518 QSDKHDRRRSQSIEQESQE 536
K DR+ + + +E
Sbjct: 210 ---KTDRQTDSQVFRPLRE 225
Score = 109 bits (272), Expect = 7e-24
Identities = 58/183 (31%), Positives = 103/183 (56%), Gaps = 9/183 (4%)
Query: 253 RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
R ER++ R R R R R R G + +RE+ ++R ER+ KERE
Sbjct: 32 RESERKKERREREKRKREREKERKRER-------GKKEKKKRKKRERGKER-ERKRKERE 83
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
K+R+ R +R ++ + RER + R R +K +R++R+RE ++ ER R++ R +
Sbjct: 84 KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 373 ERGNEREKER-ERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR 431
+ +REKER +R R+R K ++ E + +++++++ R R ++R+ KKE+K R + +
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK 203
Query: 432 ERK 434
ERK
Sbjct: 204 ERK 206
Score = 105 bits (262), Expect = 1e-22
Identities = 56/185 (30%), Positives = 98/185 (52%), Gaps = 7/185 (3%)
Query: 250 EIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAK 309
E +R ERR +R R R + R+ +E+E+QR ER
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER--- 89
Query: 310 EREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRD 369
REKERR+ + + ER++ RER + + R + +++ R+R+R+K ++ RR++R
Sbjct: 90 -REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 370 YDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSR 429
+KERG K ++R +E +++R R E KK +E K+ R+ K++ KKE++ + R
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKE---RRERKKERKKERRKKKER 205
Query: 430 SRERK 434
++RK
Sbjct: 206 KKDRK 210
Score = 105 bits (261), Expect = 1e-22
Identities = 56/190 (29%), Positives = 102/190 (53%), Gaps = 7/190 (3%)
Query: 352 RDREREKENERGRRRDRDYDKERGNER---EKERERSRERSKEQRSRGEVEEKKHKEDKD 408
R+ ER+KE +R R+ +KER ER EK++ + RER KE+ + + EK+ KE ++
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91
Query: 409 DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSR-NAGKRSRSRSKEKSSKHKNESKEKS 467
R + K K+E+K R R++K + R R N +R R R K + K + E K +
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 468 NKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRS 527
+ R + + E+ KKRE + KE+ ++R R + R K++ K++ K +R++
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERN-RKERKKERERKERRERKKER--KKERRKKKERKKD 208
Query: 528 QSIEQESQEK 537
+ ++++ +
Sbjct: 209 RKTDRQTDSQ 218
Score = 103 bits (257), Expect = 4e-22
Identities = 56/194 (28%), Positives = 104/194 (53%), Gaps = 7/194 (3%)
Query: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD 414
+RE E ++ RR +ER ER++ER + ++ +++R RG+ E+K KE + R+ R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 415 DK--RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSR 472
+K R KKEKK + R R+ R + + R +R + +E+ K K K++ +R R
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRK-KRRKKKRRKERKR 149
Query: 473 SGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQ 532
+G+ + K +K+E +EK R+R+R KER +R+ + +++ + + R + E+
Sbjct: 150 EKERGKRERKRKKRKKE---EREKKRERNR-KERKKERERKERRERKKERKKERRKKKER 205
Query: 533 ESQEKQHKNKDETV 546
+ K + D V
Sbjct: 206 KKDRKTDRQTDSQV 219
Score = 93.2 bits (230), Expect = 5e-19
Identities = 56/196 (28%), Positives = 105/196 (53%), Gaps = 24/196 (12%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
+++ + R R+ ++ + G +E + +R R + R R R+ R R+
Sbjct: 42 EREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRK----- 96
Query: 290 SFDRELEREKERQRLEREAK-EREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGD 348
R+KE+++ ER+ + RE+++++ R ER R + R R R + R +K
Sbjct: 97 -------RKKEKKKRERKQRGRRERKKKKERK-----ERERENKQRRERKRKKRRKKK-- 142
Query: 349 RRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKD 408
R +ER++E ERG +R+R K + EREK+RER+R+ K++R R E E+K + K+
Sbjct: 143 ---RRKERKREKERG-KRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198
Query: 409 DRRHRDDKRDSKKEKK 424
R+ ++ K+D K +++
Sbjct: 199 RRKKKERKKDRKTDRQ 214
Score = 90.1 bits (222), Expect = 5e-18
Identities = 54/167 (32%), Positives = 91/167 (54%), Gaps = 12/167 (7%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
+ +K +K + G E + ER + R RR R+ + + R + G RE
Sbjct: 61 KEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR------RER 114
Query: 296 EREKERQRLEREAKER-EKERRRSRSIDRGLERRRSR---SRERHRSRSRSRDRKGDRRD 351
+++KER+ ERE K+R E++R++ R R ER+R + RER R + + +R+ R
Sbjct: 115 KKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRER 174
Query: 352 RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEV 398
+ER+KE ER RR+R KER ER K++ER ++R ++++ +V
Sbjct: 175 NRKERKKERERKERRER--KKERKKERRKKKERKKDRKTDRQTDSQV 219
Score = 73.2 bits (178), Expect = 6e-13
Identities = 47/167 (28%), Positives = 90/167 (53%), Gaps = 16/167 (9%)
Query: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293
K R RK K+ K+ E R ERR+ + ++ ++ RR R + R+ +R
Sbjct: 73 KERERKRKEREKQRKER--REKERRKRKKEKKKRERKQRGRRERKKKKERKER-----ER 125
Query: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGL-ERRRSRSRERHRSRSRSRDRKGDRRDR 352
E ++ +ER+R +R K+R KER+R + +RG ER+R + ++ R + R R+RK +++R
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREK--ERGKRERKRKKRKKEEREKKRERNRKERKKER 183
Query: 353 DRE------REKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
+R+ +E++ ER ++++R D++ + + + R S R
Sbjct: 184 ERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNR 230
Score = 69.7 bits (169), Expect = 6e-12
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 16/152 (10%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRR---SPRRSRSRSHH 282
+K ++Q K R K ++ K+ ++ +R RR R ++ R RR R R
Sbjct: 79 RKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 283 REGHGSSSFDRELEREK-ERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR 341
R+ RE ER K ER+R +R+ +EREK+R R+R + R + RER R R
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNR-------KERKKERERKERRER 191
Query: 342 SRDRKGDRRDRDREREKENERGRRRDRDYDKE 373
++RK +RR ++KE ++ R+ DR D +
Sbjct: 192 KKERKKERR-----KKKERKKDRKTDRQTDSQ 218
Score = 57.0 bits (136), Expect = 4e-08
Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 4/119 (3%)
Query: 424 KHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
K R ERK R R KR R R KE+ + + K+K KR R + R
Sbjct: 27 KPCTQRESERKKERRERE----KRKREREKERKRERGKKEKKKRKKRERGKERERKRKER 82
Query: 484 KSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
+ +++E + + RK+ + K +R + K + ++ +R R +E + K+ + K
Sbjct: 83 EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141
Score = 29.6 bits (65), Expect = 7.4
Identities = 18/68 (26%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 482 VEKSKKREHSPSKEKSRK-----RSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQE 536
+ K + S K++ R+ R R KER +R + K + K +R + + +++ +E
Sbjct: 25 ISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRK-KRERGKERERKRKERE 83
Query: 537 KQHKNKDE 544
KQ K + E
Sbjct: 84 KQRKERRE 91
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 120 bits (302), Expect = 2e-27
Identities = 63/210 (30%), Positives = 113/210 (53%), Gaps = 3/210 (1%)
Query: 277 RSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERH 336
R R E +RE ER+KER+ E+ +EREKER+R R R+ RER
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 337 RSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
+ R +++G+ +++ +++EK+ ERGR ++ER ER++E + RER KE+R +
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKK-ERGRTSKEGKERERKEERKREERKERERKKEEREKE 157
Query: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS 456
+++ K ++ ++++R +KE+K + R R RK R + R R +R R + ++K
Sbjct: 158 RERKERKKRERKQVGEKEEER-KEKERKERKKRERNRKERKKERERKE-RRERKKERKKK 215
Query: 457 SKHKNESKEKSNKRSRSGSQGRTDSVEKSK 486
+ K E ++ R +G+ + E+ K
Sbjct: 216 EERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 115 bits (287), Expect = 1e-25
Identities = 71/222 (31%), Positives = 117/222 (52%), Gaps = 20/222 (9%)
Query: 299 KERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRKGDRRDRDRERE 357
+ER+R KE +KER R +R +R R RE+ R R R + ++KG+R+ +RER+
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 358 KENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEV-EEKKHKEDKDDRRHRDDK 416
K R R+ + + G E+EK ++ KE++ RG +E K +E K++R+ ++
Sbjct: 99 K-------RRREKENKEGEEKEKRKK------KEKKERGRTSKEGKERERKEERKR--EE 143
Query: 417 RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSR-SKEKSSKHKNESKEKSNKRSRSGS 475
R ++ KK R + RERK R + + G++ R KE+ + K E K K+ R
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERK 203
Query: 476 QGRTDSVEKSKKREHSPSKEKSRKRS-RSKERSHKRDHSDSK 516
+ R E+ KK E ++K R+ + R KER KR+ + K
Sbjct: 204 ERRERKKERKKKEERKKERQKDRQTNWREKERG-KRERKERK 244
Score = 114 bits (285), Expect = 2e-25
Identities = 61/210 (29%), Positives = 115/210 (54%), Gaps = 8/210 (3%)
Query: 261 RSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAK-EREKERRRSR 319
R R + R+ ++ R +E RE E+E++R+R ++E K ER+KE R +
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 320 SIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNERE 379
R E + +E+ + + + + + ++RER++E +R R++R+ KE ERE
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE---ERE 155
Query: 380 KERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKK---EKKHSRSRSRERKHR 436
KERER + +E++ GE EE++ ++++ +R+ R+ R +K E+K R R +ERK +
Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKK 215
Query: 437 -SRSRSRNAGKRSRSRSKEKSSKHKNESKE 465
R + R +++ R KE+ + + E K+
Sbjct: 216 EERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 113 bits (282), Expect = 5e-25
Identities = 73/229 (31%), Positives = 119/229 (51%), Gaps = 14/229 (6%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
Q +I+ R R+I+ KEG +E R ER++ R R R R R R +E
Sbjct: 31 QPGWQSEIREREREIETR-KEGKKE--RESERKKERREREKRKREREKERKRERGK-KEK 86
Query: 286 HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR 345
G ++ ERE++++R E+E KE E++ +R + + R +ER R R R+
Sbjct: 87 KGER---KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREE 143
Query: 346 KGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE 405
+ +R + EREKE ER R+ R ++++ E+E+ER+ + +++R R E KK +E
Sbjct: 144 RKERERKKEEREKERERKERKKR--ERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201
Query: 406 DKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKE 454
K +RR R +R K+E+K R + R+ R + R GKR R K+
Sbjct: 202 RK-ERRERKKERKKKEERKKERQKDRQTNWREKER----GKRERKERKK 245
Score = 106 bits (264), Expect = 6e-23
Identities = 64/213 (30%), Positives = 110/213 (51%), Gaps = 18/213 (8%)
Query: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRER 388
+S RER R RK +++R+ ER+KE +R R+ +KER ER K +E+ ER
Sbjct: 35 QSEIRERERE---IETRKEGKKERESERKKERREREKRKREREKERKRERGK-KEKKGER 90
Query: 389 SKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRS 448
KE+R E KK + +K+++ + ++ KKEKK S+E K R R K
Sbjct: 91 KKEER-----ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER-------KEE 138
Query: 449 RSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSH 508
R R + K + K E +EK +R + R EK ++R+ KE+ ++ KER
Sbjct: 139 RKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198
Query: 509 KRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541
+R+ + +++ K +R++ + ++E Q+ + N
Sbjct: 199 ERERKERRER--KKERKKKEERKKERQKDRQTN 229
Score = 86.3 bits (212), Expect = 7e-17
Identities = 47/178 (26%), Positives = 90/178 (50%), Gaps = 7/178 (3%)
Query: 368 RDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR 427
R+ ++E +E ++ER ER KE+R R E++K + +K+ +R R K + KK R
Sbjct: 39 REREREIETRKEGKKERESERKKERRER---EKRKREREKERKRERGKKEKKGERKKEER 95
Query: 428 SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKK 487
R + R+ + KR + KE+ K E KE+ K R + R + K ++
Sbjct: 96 ERKKRRREKENKEGEEKEKRKKKEKKERGRTSK-EGKERERKEERKREE-RKERERKKEE 153
Query: 488 REHSPSKEKSRKRSRSK--ERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
RE +++ +KR R + E+ +R + K++ + R+ + E+E +E++ + K+
Sbjct: 154 REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKE 211
Score = 80.5 bits (197), Expect = 4e-15
Identities = 50/169 (29%), Positives = 86/169 (50%), Gaps = 16/169 (9%)
Query: 380 KERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR---ERKHR 436
+ERER E KE + E E KK + +++ R KR+ +KE+K R + ERK
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKR-----KREREKERKRERGKKEKKGERKKE 93
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
R R + ++ +EK + K E KE R R+ +G+ ++ +KRE +E+
Sbjct: 94 ERERKKRRREKENKEGEEKEKRKKKEKKE----RGRTSKEGKERERKEERKREERKERER 149
Query: 497 SRKRSRSKERSHK-RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
+K R KER K R + K +K + R+ + E++ ++K+ +N+ E
Sbjct: 150 -KKEEREKERERKERKKRERKQVGEKEEERKEK--ERKERKKRERNRKE 195
Score = 42.7 bits (99), Expect = 8e-04
Identities = 22/100 (22%), Positives = 46/100 (46%), Gaps = 13/100 (13%)
Query: 445 GKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK 504
G +S R +E+ + + E K++ E+ K+R +++ R++ R +
Sbjct: 33 GWQSEIREREREIETRKEGKKERES-------------ERKKERREREKRKREREKERKR 79
Query: 505 ERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
ER K + K + + +RR + +E +EK+ + K E
Sbjct: 80 ERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKE 119
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 111 bits (278), Expect = 1e-24
Identities = 73/309 (23%), Positives = 153/309 (49%), Gaps = 15/309 (4%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
+QQ++ RK +++ +E EE ERR + RR RR R + RE
Sbjct: 303 EQQLR---RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE----- 354
Query: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR 349
+E ER +++ R E+E + RE++ RR + + R + RR + R + R + + ++
Sbjct: 355 ---QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 350 RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDD 409
+ R RE++ E+ RR+++ ++ ++ RE+ +R +E+R E++ + + +
Sbjct: 412 QLR-REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 410 RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNK 469
RR + KRD ++E++ + E + R + R R + + + E +E+ +
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 470 RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ-SDKHDRRRSQ 528
R RS Q R + ++ ++ + +E+ R +E+ KR+ + +DQ + + RR Q
Sbjct: 531 RLRSEQQLRRE--QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588
Query: 529 SIEQESQEK 537
+++E +E+
Sbjct: 589 RLKREQEER 597
Score = 110 bits (274), Expect = 4e-24
Identities = 76/322 (23%), Positives = 160/322 (49%), Gaps = 22/322 (6%)
Query: 241 KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE 300
K++ K EE R E + R L R+ RR R ++ +++L R++E
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLE-RQELRRERQEEEQQQQRLRR--EQQLRRKQE 311
Query: 301 RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN 360
+R E++ + RE++ RR + +R E++ R +E R + R+++ +RR++ RE+E
Sbjct: 312 EERREQQEERREQQERREQQEERR-EQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 361 ERGR---RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKR 417
ER RR++ +E+ RE++ R ++ +EQ+ R E + ++ ++ + +++ R ++
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Query: 418 DSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--------NESKEKSNK 469
+ + E+KH + R +R R + R+ KR + + + K E +E+ K
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 470 RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRR---- 525
+ + + E+ +RE +E+ KR +ER +R S+ + + ++ +RR
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 526 ---RSQSIEQESQEKQHKNKDE 544
+ +EQE +E++ K + E
Sbjct: 551 KREEEKRLEQERREQRLKREQE 572
Score = 108 bits (270), Expect = 1e-23
Identities = 75/317 (23%), Positives = 153/317 (48%), Gaps = 13/317 (4%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSP--RRSRSRSHHREGHG 287
+QQ++ + ++ +++ R + RR + RR RR RR + H + H
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 288 SSSFDRELEREKERQR--LEREAK-EREKERRRSRSIDRGLERRRSRSRERH-RSRSRSR 343
++ L+RE+E +R L+RE + ER ++ RR + + R E R RER + R
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER---RERWLKLEEEER 496
Query: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH 403
+ +RR++ RE+E R +R R ++ER +R + ++ R R +E+R ++ ++
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR-REQEERREQLLKREEE 555
Query: 404 KEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNES 463
K + +RR + KR+ ++ + R ER+ + R + R + +E + E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 464 KEKSNKRSRSGSQGRTD---SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSD 520
+E+ KR + R S E+ ++R+ +E+ +R + +R + + + + + +
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 521 KHDRRRSQSIEQESQEK 537
+ RR Q + +E QE+
Sbjct: 676 HEEERREQELAEEEQEQ 692
Score = 105 bits (263), Expect = 8e-23
Identities = 83/331 (25%), Positives = 160/331 (48%), Gaps = 23/331 (6%)
Query: 230 DQQIKTRPRKIKKDGKEGAEE--IDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHG 287
+Q+ + R ++++++ +E E + R + RR + RR RR + R + RE
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 288 SSSFDRELEREKE---RQRLEREAKEREKERRRSRSIDRGLERR----RSRSRERHRSRS 340
+++L RE++ Q ER ++ E+ERR R ERR R ERH
Sbjct: 414 RR--EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 341 RSRDRKGDRRDRDRER------EKENERGRRRDRDYDKERGNEREKERERSRERSK-EQR 393
R + K D+ + RER E+ E+ RR++ +E+ RE+ +R E + +QR
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 394 SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSK 453
R E + ++ +E +RR + KR+ +K + R R ++ + R + KR R +
Sbjct: 532 LRSEQQLRREQE---ERREQLLKREEEKRLEQERREQRLKREQEERRDQLL-KREEERRQ 587
Query: 454 EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHS 513
++ + + E E+ KR + + E+ KRE P +E+ ++ +S+E+ +R
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKRE-EPEEERRQQLLKSEEQEERRQQQ 646
Query: 514 DSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
++Q ++ ++R + E+E E++ K + E
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHE 677
Score = 105 bits (262), Expect = 1e-22
Identities = 77/338 (22%), Positives = 157/338 (46%), Gaps = 28/338 (8%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEI---DRHVERRRSRSPRRSLSPRRSPRRSRSRSHH 282
Q+ +QQ + R ++++++ +E E+ ++ ERR + R RR + R +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 283 REGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS 342
RE RE + +E+Q + RE++ RR + + R + RR + ERH +
Sbjct: 385 RE----QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK-HE 439
Query: 343 RDRKGDRRDRDRE-------REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
++R+ R R++E RE+E ER + R +R E E+ + +E+R +
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 396 GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR------SRNAGKRSR 449
E E++ + ++++RR + KR ++E+ R RS ++ R + R KR
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 450 SRSKEKSSKHKNES------KEKSNKRSRSGSQGRTDSVEKSKKREH-SPSKEKSRKRSR 502
+E+ K + E K + +R + + + + +E+ KRE +++ R+ R
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Query: 503 SKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK 540
K + + +S++ + RR Q + +E QE++ +
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Score = 102 bits (255), Expect = 7e-22
Identities = 69/318 (21%), Positives = 152/318 (47%), Gaps = 18/318 (5%)
Query: 243 DGKEGAEEIDRHVERRRSRSP------RRSLSPRRSPRRSRSRSHHREGHGSSSF-DREL 295
+G+E +E+ +R +R R R R+ R R + +GH + F D E
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
R +E L R+ +E ++++RR R DR + + + + R + K + R+
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQ-DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDD 415
RE + E + R + + R +E+E+++ R R ++Q R + EE+ +E +++RR + +
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQEERREQQE 326
Query: 416 KRDSKKEKKHS--RSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
+R+ ++E++ R ER+ + R + +R + +E+ + + + + + R
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 474 GSQGRTDSV--EKSKKREHSPSKEKSRKRSRS--KERSHKRDHSDSKDQSDKHDRRRSQS 529
R + E+ +RE +E+ +R + +E+ +R+ + + + RR Q
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR 446
Query: 530 IEQESQEKQH--KNKDET 545
+++E +E++ K ++ET
Sbjct: 447 LKREQEERRDWLKREEET 464
Score = 102 bits (255), Expect = 7e-22
Identities = 76/346 (21%), Positives = 155/346 (44%), Gaps = 32/346 (9%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
+QQ++ R ++++++ +E E ERR R R R +R H +
Sbjct: 416 EQQLR-REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 290 SFDRELEREKERQRLEREAKER-EKERRRSRSIDRGLERRRS----RSRERHRSRSRSRD 344
R+ E E+ + L+ E +ER E++ RR + + R E RR R E R + R R
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 345 RKGDRRDRDREREK----------ENERGRRRDRDYDKERGNE---REKERERSR----- 386
+ RR+++ RE+ E ER +R + +ER ++ RE+ER + R
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 387 -ERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKE---KKHSRSRSRERKHRSRSRSR 442
ER +++ R EVE + +E ++ R R++ + +++ K + R+++ R + R
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 443 NAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKR----EHSPSKEKSR 498
+ R +E+ + E+ + + + + E+ K R + E
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 499 KRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
++S+ R K++ + + ++ RRR ++ + +E+ H+ + E
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE 760
Score = 99.0 bits (245), Expect = 1e-20
Identities = 78/328 (23%), Positives = 158/328 (48%), Gaps = 32/328 (9%)
Query: 249 EEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRE-LEREKERQRLERE 307
E+++R ++ R R+S ++ R R R+ + E L +E+E Q L R+
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 308 AKEREKERRRSRSIDRGL----ERRRSRSRERHRS------RSRSRDRKGD-RRDRDRE- 355
++R+ R ++G E +R R +ER R + R ++R+ R+DRDR+
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 356 REKENERGRR-RDRDYDKERGNEREKERERS----RERSKEQRSRGEVEEKKHKEDKDDR 410
RE+E + R+ RDR + +E R +ERER ++ +++R R EE++ ++++++
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Query: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNE------SK 464
+ +RD K ++ + R +ER + R + + + R +E+ H+ + +
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 465 EKSNKRSRSGSQGRTDSVEK--------SKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516
E+ +R G Q R D K ++ E S+++ ++ R +E+ +R + K
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 517 DQSDKHDRRRSQSIEQESQEKQHKNKDE 544
D+ RR + +Q QE+ K +++
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Score = 97.8 bits (242), Expect = 2e-20
Identities = 79/366 (21%), Positives = 163/366 (44%), Gaps = 52/366 (14%)
Query: 230 DQQIKTRPRKIKKDGKEGAEE-------IDRHVERRRSRSPRRSLSPRRSPRRSRS---- 278
DQ+ + R R +K + +E E+ + R E RR + +R R +R RS
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 279 ---RSHHREGHGSSSFDRELEREKERQRLEREAKERE------KERRRSRSIDRGLERR- 328
+ RE ++ LE+E+ QRL+RE +ER +E RR + + R E R
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 329 ----------RSRSRERHRSRSRSRDRKGDRRD---RDREREKENERGRRRDRDYDKERG 375
R ER R + + + +RR + E+E+ ++ RR++ +E+
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 376 NEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR------------DDKRDSKKEK 423
+RE+E ER +R K + E++ +E+++ R R + + D+++ K
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 424 KHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
+SR R +E + R + + +R ++ + + +E+ +R + + E
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 484 KSKKR--EHSPSKEKSRKRSRSKERSHKRD----HSDSKDQSDKHDRRRSQSIEQESQEK 537
+ ++R P +E+ ++ R++ER + + K+Q + R R + ++ +E+
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 538 QHKNKD 543
Q + ++
Sbjct: 839 QLQRRE 844
Score = 97.8 bits (242), Expect = 2e-20
Identities = 78/347 (22%), Positives = 163/347 (46%), Gaps = 35/347 (10%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
++Q++ R R + +E + D+ ERRRS+ RR R R R H +
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQ--ERRRSQEQRRDQKWRWQLEEERKRRRHTL-YAKP 893
Query: 290 SFDREL--------EREKERQRLEREAKEREKERRRSRS---IDRGLERRRSRSRERHRS 338
+ +L E E+E QR ERE + R+++ R+ R + + E+ RE+ R
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 339 RSRSRDRKGDRRDRDRE-----REKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
+ R R + D++ + +E E E R + R++ Y +E ++E+E+ ER K +R
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 394 SRGE-----------VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSR 442
E EE+ +E+++ RR ++ +R ++E++ + + +R R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 443 NAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSR 502
+R + +E + + +E+ KR R + + E+ ++ E +E+ KR R
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Query: 503 SK-ERSHKRDHSDSKDQS----DKHDRRRSQSIEQESQEKQHKNKDE 544
+ ER ++ + +++ ++ ++RR Q +E++ +E++ ++E
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Score = 95.1 bits (235), Expect = 1e-19
Identities = 81/346 (23%), Positives = 171/346 (49%), Gaps = 31/346 (8%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
++ + Q++++ ++++++ +E E++ + E +R RR +R R + RE
Sbjct: 525 EERLQQRLRSE-QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 286 HGSSSFDRELEREKERQRLEREAKER-EKERRRSRSIDR---GLERR----RSRSRERHR 337
+ + E+ QRL+RE ER E+E RR + + R ERR +S +E R
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 338 SRSRSRDRKGDRRDRDREREKENER-GRRRDRDYDKERGNER--EKERERSRERSKEQ-- 392
+ R+++ +RR++ +RE+E ER +R R++++ER + E+E+E++RER K +
Sbjct: 644 QQQLRREQQ-ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 393 ----RSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS------RERKHRSRSRSR 442
+ E + ++ K R+ +R ++E+K R S ER HR +
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 443 NAGKRS-RSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRS 501
+ + +++EKS + + + R + Q R + ++ ++R +EK ++R
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 502 RSKERSHKRDHSDSKDQSDKHDRRRSQSIEQES---QEKQHKNKDE 544
+ +ER + + ++Q + R R+Q +++E QE Q + + +
Sbjct: 823 QRREREKELQFLEEEEQLQR--RERAQQLQEEEDGLQEDQERRRSQ 866
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/328 (21%), Positives = 147/328 (44%), Gaps = 14/328 (4%)
Query: 231 QQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPR--RSPRRSRSRSHHREGHGS 288
+Q + +++K++ E E+ +R +R + P + +S + R
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 289 SSFDRELEREKERQRLEREAK-EREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
++ L+RE+E +RLE+ K E E+ERR + E+ R R + R + +
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 348 D-RRDRDREREKENERGRRRDRDYDKERGNERE---KERERSRERSKEQRSRGEVEEKKH 403
D R+ + R ++ E RRR +K R E E +E ER+ + +E+ R + +
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ 772
Query: 404 KEDKDDR-RHRDDKRDSKKEKKHSRSRSRERKHRSR----SRSRNAGKRSRSRSKEKSSK 458
E+K +R R R R +E++ + R+ ER+ R + +R + R +EK +
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ 832
Query: 459 HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRK--RSRSKERSHKRDHSDSK 516
E ++ + Q D +++ ++R S + + +K +ER +R +K
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 517 DQSDKHDRRRSQSIEQESQEKQHKNKDE 544
+ R+ Q +++E +E Q + +++
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREK 920
Score = 93.2 bits (230), Expect = 5e-19
Identities = 72/349 (20%), Positives = 155/349 (44%), Gaps = 42/349 (12%)
Query: 232 QIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSF 291
++ +RPRK +EG E+RR R R + R + +
Sbjct: 718 KVYSRPRK-----QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF-TWQW 771
Query: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD 351
E + E+ RQRL RE+ R+ R+ +R +R E + + R + R+ ++
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 352 RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKK--------- 402
+ E E++ +R R + ++E G + ++ER RS+E+ ++Q+ R ++EE++
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 403 ----------------------HKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
+E+++ RR ++ +R ++E++ + + + R
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 441 SRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR 500
R +R + K+ K + E+ KR R + + E+ ++ E +E+ KR
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 501 SRSK-ERSH-KRDHSDSKDQS---DKHDRRRSQSIEQESQEKQHKNKDE 544
R + ER + K+D +++ ++ ++RR Q E++ +E++ ++E
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Score = 92.4 bits (228), Expect = 9e-19
Identities = 78/338 (23%), Positives = 155/338 (45%), Gaps = 37/338 (10%)
Query: 238 RKIKKDGKEGAEEIDRHVERRRSRSPR-RSLSPRRSPRRSRSRSHHR----EGHGSSSFD 292
++ + DGKE + R E +R PR R L RR + R EG S
Sbjct: 99 KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ 158
Query: 293 RELE------REKERQRLEREAKEREKERRRSRSID--RGLE----------RRRSRSRE 334
LE R++E R +E +ERE+ R + +G E RRR
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 335 RHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRS 394
R + R + ++ +R+DR + E+E E R+R+ KE +E+E +R RE +E+
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKE-WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277
Query: 395 -----RGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSR 449
R E+ ++ +E++ +R R +++ +K+++ R + ER+ + R + +R +
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 450 SRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK 509
+E+ + + + + + + R Q R + E+ ++++ ++ R++ +E+ +
Sbjct: 338 QLRREQEERREQQLRREQEEERRE-QQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 510 RDHSDSKDQSDKHDRRRSQSIEQESQ---EKQHKNKDE 544
R+ ++Q RR Q + +E Q E+Q + + E
Sbjct: 397 REQQLRREQQ----LRREQQLRREQQLRREQQLRREQE 430
Score = 92.4 bits (228), Expect = 9e-19
Identities = 79/328 (24%), Positives = 151/328 (46%), Gaps = 29/328 (8%)
Query: 244 GKEGAEEIDRHVERRRS--RSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKER 301
G E E D RRR R+ ++ RR R +E RE KE
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE 257
Query: 302 QRLEREAKEREKERRRSRSIDRGLER---RRSRSRE-------------RHRSRSRSRDR 345
++L+ E +R++E + R LER RR R E R + R++
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 346 KGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE 405
+ +RR++ RE++ ER ++ R +ER E++ RE+ ER ++Q R + EE++ ++
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEER-REQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 406 ---DKDDRRHRDDKRDSKKEKKHSRSRS----RERKHRSRSRSRNAGKRSRSRSKEK-SS 457
++ RR + +R+ + ++ R RE++ R + R + R + +E+
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKD 517
KH+ E +E+ KR + + E++++ E K++ KR + +ER + + ++
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ-LKRDQEEERRERWLKLEEEE 495
Query: 518 QSDKHDRRRSQ-SIEQESQEKQHKNKDE 544
+ ++ +RR Q EQE + +Q + E
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQE 523
Score = 91.7 bits (226), Expect = 2e-18
Identities = 72/342 (21%), Positives = 159/342 (46%), Gaps = 29/342 (8%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
+QQ++ + ++ ++ +E + R+ R + ++ R+ R R + S
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 290 SFDRE-LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSR---ERHRSRSRSRDR 345
+R+ LE E++ R +R+ K ++E++ R +RG +RR+ R R E + R ++
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ-ERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 346 KGDRRDRDRE--------REKENERGRRRDRDYDKERGNEREKERERSRE-RSKEQRSRG 396
+ R++RDR+ R +E ER D + + +++ +ER R+ R EQ +
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE 1630
Query: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS 456
E++ H++++D + ++ + ++E++ R+RK R + G+ + R +E+
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Query: 457 SKHKNESK-----EKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK-- 509
K + E + E+ K + Q R +E+ + E +E +++ R +ER K
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 510 --------RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
R+ + Q R + + QE +E+Q ++++
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Score = 90.9 bits (224), Expect = 3e-18
Identities = 68/341 (19%), Positives = 159/341 (46%), Gaps = 28/341 (8%)
Query: 230 DQQIKT-RPRKIKKDGKE-GAEEIDRHVER-----RRSRSPRRSLSPRRSPRRSRSRSHH 282
+QQ++ R RK +++ ++ +E DR RR R+ L + R+ R R
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 283 REG-----------HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSR 331
E H + LE E++ +R ER+ K RE+E R + LE +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 332 SRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE-RSK 390
R++ + + +++ R++R ++R ++ +R R + +ER ++ +ER R+ R +
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 391 EQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS--------RSRSRERKHRSRSRSR 442
EQ+ R + +E+K ED+ R ++ ++ ++E+ + R ++ HR +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 443 NAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSR 502
+ + R +E+ + +++ K + + +G + + ++R+ +E+ + R +
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQ 1703
Query: 503 SKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
+ER ++ + Q + R + + QE++++Q + ++
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Score = 89.7 bits (221), Expect = 6e-18
Identities = 70/364 (19%), Positives = 168/364 (46%), Gaps = 45/364 (12%)
Query: 224 PVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLS----PRRSPRRSRSR 279
P+++ ++Q++ R+ +++ + EE ++ RR+ R + L + RR R++
Sbjct: 789 PLREQRERQLRAEERQ-QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 280 SHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSR-------SIDRGLERRRSRS 332
E G D+E R +E++R ++ + E+ER+R R ++ L + +
Sbjct: 848 QLQEEEDGLQE-DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 333 RERHRSRSRSRDRKGDRRDRDRE----------------REKENERGRRRDRDYDKER-- 374
+E R K R++++R+ E+E R + R+R Y K++
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 375 --------GNEREKERERSRERS-KEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKE--- 422
G E EK R + RE+ +E+ + EE+ +E+++ RR ++ +R +K+
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 423 KKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSV 482
++ RE + + R + R R +++ + E +E ++ + + +
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 483 EKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ--SDKHDRRRSQSIEQESQEKQHK 540
++ +++ EK R++ R ++ + + ++Q ++ ++RR Q +E++ +E++
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 541 NKDE 544
++E
Sbjct: 1147 QQEE 1150
Score = 89.7 bits (221), Expect = 6e-18
Identities = 87/363 (23%), Positives = 167/363 (46%), Gaps = 65/363 (17%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
+++ K R +++++ +E EE+ + E+ P + RR +RE
Sbjct: 1126 EEREKRRRQELERQYRE-EEEVQQEEEQLLREEPEKR-------RRQELERQYREEEELQ 1177
Query: 290 SFDREL---EREKERQRLEREAKEREKERRRSRSIDRGLERRRS---------------- 330
+ +L E+EK RQ ER+ +E E+ +R+ R E +RS
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Query: 331 -----RSRERHRSR----SRSRDRKGDR-------RDRDREREKENERGRRRDRDYDKER 374
+ RE + R S+ RDR+ + ++R+RE+E R ++RDR + +E
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297
Query: 375 GNEREKERERSRERSKEQRS----RGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS 430
ERE+++E R K Q R E EEK+ +++ D + +++ ++E++ R +
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 431 RERKHRSRS-RSRNAGKR-----SRSRSKEKSSKH-KNESKEKSNKRSRSGSQGRTDSVE 483
R+RK R R + G++ R R +E+ K K E + + +R + Q R D
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ---QLRQDRDR 1414
Query: 484 KSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK----DQSDKHDR----RRSQSIEQESQ 535
K ++ E S+++ ++ R +E+ +R + K +Q + +R R + + QE +
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 536 EKQ 538
E+Q
Sbjct: 1475 EQQ 1477
Score = 89.7 bits (221), Expect = 6e-18
Identities = 79/332 (23%), Positives = 159/332 (47%), Gaps = 29/332 (8%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
D++ + +K+++ +E D RR+ + R R RE
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 290 SFDRE---LEREKERQRLEREAKEREKERRRSRSIDRGL---ERRRSRSRERHRSRSRSR 343
+R+ LE E + +R ERE + R R+ R ++ L E ++ R +ER R + R
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-KFREE 1696
Query: 344 DRKGDRRDRDRE--------REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
+++ R++R+R+ R +E ER R + +E E+ + +ER R+ +E++ R
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 396 GEVEEKKHKEDKDDRRHRDDKR-DSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKE 454
E EE++ + + DR+ R++++ ++E++ RS+ +RK R + R + + R ++
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816
Query: 455 KSSKHKNE------SKEKSNKRSRSGSQGRTD----SVEKSKKREHSPSKEKSRKRSRSK 504
+ K++ E +++ R Q R + + EKS++ E +E+ +KR + +
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 505 ERSHKRDHSDSKDQSDKHDRRRSQSIEQESQE 536
ER + +H + K ++R Q E +SQE
Sbjct: 1877 ERKLREEHI---RRQQKEEQRHRQVGEIKSQE 1905
Score = 88.6 bits (218), Expect = 1e-17
Identities = 67/326 (20%), Positives = 145/326 (44%), Gaps = 14/326 (4%)
Query: 224 PVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHR 283
P ++ Q +K+ ++ ++ + E+ ERR R R R R R R
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQ----QERREQRLKREEEEERLEQRLKREHEEER 680
Query: 284 EGHGSSSFDRELEREKERQRLER--EAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR 341
+ ++E RE+ + R+ + E E + R+S+ R ++ R R+ + R
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 342 SRDRKGDRRDRDREREKENERGRRRD--RDYDKERGNEREKERERSRERSKEQRSRGEVE 399
R+ + ++ +R ++ E +RRD + E +ER ++R +R +EQR E
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR-----E 795
Query: 400 EKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKH 459
+ E++ R R + +KE++ + R RE++ + +R R++ ++
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 460 KNESKE-KSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ 518
E +E + ++ R + R E+ K+R H+ + + + KE+ ++ + +
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 519 SDKHDRRRSQSIEQESQEKQHKNKDE 544
++ RRR + Q +E+Q + ++E
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEE 941
Score = 87.8 bits (216), Expect = 2e-17
Identities = 67/324 (20%), Positives = 150/324 (46%), Gaps = 15/324 (4%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLS------PRRSPRRSRSRSHHR 283
+++ R K+ G+E + + R R ++ L R + R R R
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
+ H E E +KE +R +R+++E ++ R R R + + RE +
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH 403
++ R++RDR+ +E R + + R + +E R +ERER + +EQ+ R + E++
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER-KFLKEEQQLRCQEREQQL 1408
Query: 404 KEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNES 463
++D+ DR+ R++++ ++++ + R E++ R + R R + + +E+ K + E
Sbjct: 1409 RQDR-DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 464 ---KEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSD 520
+E+ ++ + R E+ + R +E+ RK + RS + + +++
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRR----QERDRKFREQELRSQEPERKFLEEEQQ 1523
Query: 521 KHDRRRSQSIEQESQEKQHKNKDE 544
H ++R + QE Q+ + + + +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQ 1547
Score = 84.7 bits (208), Expect = 2e-16
Identities = 73/355 (20%), Positives = 159/355 (44%), Gaps = 26/355 (7%)
Query: 216 TLFPRIPVPVQKNIDQQI-KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPR 274
TL+ + + Q +QQ+ + +++++ +E ++ ER+ + + R
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ--ERQYREEEQLQQEEEQLLR 945
Query: 275 RSRSRSHHREGHGSSSFDRELEREKER----QRLEREAKEREKERRRSRSIDRGLERRRS 330
R + +E D++L++++E+ + +R +EREK+ R + + E+
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005
Query: 331 RSRERHRSRSRSRD-RKGDRRDRDRER----EKENERGRRRDRDYDKER----------G 375
RE+ R + R RK D ++ E+ E+E R + R+R Y +E G
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 376 NEREKERERSRERS-KEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERK 434
ERE R + ER +++ + EE+ +E+ + RR ++ +R ++E++ + + +
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Query: 435 HRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSK 494
R R +R +E + + +E+ KR R + + E+ ++ E +
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 495 EKSRKRSRSKERSHKRDHS---DSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546
E+ KR + +ER ++ + + Q + + +RS Q EK++ +D V
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/288 (22%), Positives = 130/288 (45%), Gaps = 23/288 (7%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKER----- 311
RR+ R +R R R RE S +R+ + E Q++ R+ +ER
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 312 EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYD 371
E++ RR + + R + RE + +++ R++RDR+ +E + RR++R+
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Query: 372 KERGNERE-KERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS 430
+R+ +E E+ + +EQ+ R + ++K +E++ R ++ +R +E++ R +
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720
Query: 431 RERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREH 490
ERK R + R ++ + R +E+ K E Q R + E+ +R+
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEE------------QLRPEREEQQLRRQ- 1767
Query: 491 SPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQ 538
E+ RK ++ +R+ + Q R + + QE +E+Q
Sbjct: 1768 ----ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Score = 83.2 bits (204), Expect = 6e-16
Identities = 72/335 (21%), Positives = 157/335 (46%), Gaps = 21/335 (6%)
Query: 225 VQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE 284
+Q+ +Q ++ K ++ E +++ + R RR R R +RE
Sbjct: 996 LQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ---YRE 1052
Query: 285 GHGSSSFDREL---ERE-KERQRLERE-AKEREKERRRSRSIDRGLERRRSRSRERHRSR 339
+ +L ERE + RQ LER+ KE E ++ + + E+RR + RER
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCRE 1112
Query: 340 SRSRDRKGD---RRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
++ + R +R++ R +E ER R + + +E +E E+ R + E++ R
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR- 1171
Query: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS 456
EE+ +E++ R +KR ++E+++ +R+ R + R R+ +RS + + +
Sbjct: 1172 -EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR-KQRYRDEDQRSDLKWQWEP 1229
Query: 457 SK------HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKR 510
K +K K + N++ R + + + +H +++ R R + + R +R
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 511 D-HSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
D H ++Q ++ +++ ++ +++SQE++ ++E
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Score = 82.8 bits (203), Expect = 7e-16
Identities = 73/312 (23%), Positives = 149/312 (47%), Gaps = 20/312 (6%)
Query: 226 QKNIDQQIKTRPRKIKKDGK--EGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHR 283
Q+ Q + R RK ++D + + EE H + R + RR R + R H R
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR-HDR 1665
Query: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
+ + +L +E E Q+L R+ ER+++ R R ER R +E + R +
Sbjct: 1666 DRKFRE--EEQLLQEGEEQQLRRQ--ERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 344 DRKGDRRDRDREREKENERGRRRDRDYDK---------ERGNEREKERERSRERSKEQRS 394
+RK R + +E E E+ RR++R Y K ER ++ + +ER R+ +E++
Sbjct: 1722 ERKF-REEEQLRQETEQEQLRRQER-YRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 395 RGEVEEKKHKEDKDDRRHRDDKR-DSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSK 453
R E EE++ + + DR+ R++++ ++E++ R + R+ K+R ++ + +
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 454 EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPS-KEKSRKRSRSKERSHKRDH 512
E+ +++ E + + ++SR Q E+ +++E +E+ +R + +E+ H++
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
Query: 513 SDSKDQSDKHDR 524
+ H R
Sbjct: 1900 EIKSQEGKGHGR 1911
Score = 81.3 bits (199), Expect = 2e-15
Identities = 77/365 (21%), Positives = 166/365 (45%), Gaps = 55/365 (15%)
Query: 231 QQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSS 290
+Q + R +++K++ E EE + + + + RR RR + R + RE
Sbjct: 611 EQEERREQRLKREEPE--EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE-EER 667
Query: 291 FDRELEREKERQRLEREAKEREKERRRSR----------SIDRGLERRRSR--SRERHRS 338
++ L+RE E +R E+E E E+E+ R R ++ + R+S+ SR R +
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 339 RSRSRDRKGDRRDRDRERE---KENERGRRRDRDYDK--------------ERGNER--- 378
R R + ++R R RE E +E ER R+ ++ ++ ERG +R
Sbjct: 728 GQRRRQEQEEKRRR-RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 379 ------EKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR- 431
++ER+ E +++ R EE++ ++ + RR R+ + +E++ + R R
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846
Query: 432 ERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS-------GSQGRTDSVEK 484
++ + +R RS+ + + K + + +E+ +R + Q R +
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Query: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ-----SDKHDRRRSQSIEQESQEKQH 539
++ E +E+ ++R + +ER ++ + +++ ++ RRR + Q ++K+
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 540 KNKDE 544
+ K+E
Sbjct: 967 QQKEE 971
Score = 79.0 bits (193), Expect = 1e-14
Identities = 51/260 (19%), Positives = 120/260 (46%), Gaps = 9/260 (3%)
Query: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
++ D E + + + + +E+++RR DR LE + R + R +G
Sbjct: 92 ATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151
Query: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407
+ + +ER ++ +R +RRD + ++R +E+E ER E + Q +G E+ E++
Sbjct: 152 EEQSEKQERLEQRDR-QRRDEELWRQRQEWQERE-ERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 408 DDRRHRDDKRDSKKEKKHSRSRSR-------ERKHRSRSRSRNAGKRSRSRSKEKSSKHK 460
RR + R +E+K + R R E + R R K +E+ + +
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 461 NESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSD 520
+E+ R + R + E+ ++++ +++ R++ + R + + + +++ +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 521 KHDRRRSQSIEQESQEKQHK 540
+ + RR Q + +E +E++ +
Sbjct: 330 QQEERREQQLRREQEERREQ 349
Score = 78.2 bits (191), Expect = 2e-14
Identities = 69/341 (20%), Positives = 146/341 (42%), Gaps = 40/341 (11%)
Query: 229 IDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGS 288
+ ++ +TR R+ + EE+ + E+ P + RR R + R
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR---RRQERERQCREEEELQQEE 1120
Query: 289 SSFDRELEREKERQRLEREAKEREK-------------ERRRSRSIDRGLERRRSRSRER 335
RE ++ RQ LER+ +E E+ E+RR + ++R +E
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE-------- 387
+ ++++ R+R E+E +R +R+ R D+++ ++ + + E +E
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240
Query: 388 ----RSKEQRSRGEVEEKKHKEDKDDRRH---RDDKRDSKKEKKHSRSRSR---ERKHRS 437
R EQ + E + + ++ + D +H +RD ++E++ + R R E +
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300
Query: 438 RSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS 497
R + A +R R +EK + E +E+ +R + + R + + ++RE P + +
Sbjct: 1301 REEQKEAKRRDRKSQEEK--QLLREEREEKRRRQETDRKFREEE-QLLQEREEQPLRRQE 1357
Query: 498 RKRS-RSKERSHKRDHSD--SKDQSDKHDRRRSQSIEQESQ 535
R R R +E H+ ++Q + R + +++E Q
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Score = 77.4 bits (189), Expect = 3e-14
Identities = 67/336 (19%), Positives = 147/336 (43%), Gaps = 28/336 (8%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
D++ + + ++ G++ EE R + R R + R R + R+
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRS-------RSRS 342
+ +E++R+ E E + R +ER R + LE + +ERHR
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERER-----KFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 343 RDRKGDRRDRDRE--REKENERGRRRDRDYDKERGNEREKER---ERSRERSKEQRSRGE 397
+++ R++RDR+ E++ R + RDR + ++ +E ER E ++ ++QR R
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 398 VEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSS 457
++E++ ++ + R RD K ++ + RE + SR + R+ R + +
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR-QERDRKFRLEEQKVRRQE 1592
Query: 458 KHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK------RD 511
+ + +++ R + G Q ++ + + +E+ ++ +ER K +
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652
Query: 512 HSDSKDQSDKHDR----RRSQSIEQESQEKQHKNKD 543
++Q +HDR R + + QE +E+Q + ++
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Score = 70.5 bits (171), Expect = 4e-12
Identities = 66/291 (22%), Positives = 137/291 (47%), Gaps = 35/291 (12%)
Query: 225 VQKNIDQQI--KTRPRKIKKDG----KEGAEEIDRHVERRRSRSPRRSLSP---RRSPRR 275
+Q+ +QQ+ + R RK ++ ++ E+ RH R+ R + L ++ R+
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 276 SRSRSHHREGHGSSSFDRE---LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRS 332
R R E +RE L+ E++ +R E E K RE+E+ R + E+ + R
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET-----EQEQLRR 1742
Query: 333 RERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ 392
+ER+R + +R ++ R+ E +R R + +ER ++ + +E R+ +E+
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQ-ERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 393 RSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSR-SRERKHRSRSRSRNAGKRSRSR 451
+ R E EE++ + + D ++R ++ + E++ R R R+R++R+ + + +SR
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ---FATQEKSR 1858
Query: 452 SKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSR 502
+E+ + E K + + E+ + EH ++K +R R
Sbjct: 1859 REEQELWQEEEQKRRQER-------------ERKLREEHIRRQQKEEQRHR 1896
Score = 70.1 bits (170), Expect = 5e-12
Identities = 70/326 (21%), Positives = 144/326 (44%), Gaps = 22/326 (6%)
Query: 231 QQIKTRPRKIKKDGKEGAEE---IDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHG 287
++++ R R+ +++ + EE + E RR + R ++ + E
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 288 SSSFDRELE-REKERQRLEREAKER-EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR 345
+RE + RE+E + E E R E+E+RR + ++R + R + +
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELER---------QYREEEEVQQEEE 1151
Query: 346 KGDRRDRDREREKENERGRRRDRDYDKERGN-EREKERERSRERSKEQRSRGEVEEKKHK 404
+ R + ++ R +E ER R + + +E RE++ +R +ER ++ R E++ +K K
Sbjct: 1152 QLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 405 EDKDDRRHRDDKRDSKKEKKHSRSRSRE--RKHRSRSRSRN-AGKRSRSRSKEKSSKH-K 460
+ D R D + + +K + R + K R + R + R R ++ +H
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 461 NESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE-KSRKRSRSKERSHKRDHSDSKDQS 519
E +E+ ++ R Q R + ++ E KE K R R +E+ R+ + K +
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 520 DKHDR--RRSQSIEQESQEKQHKNKD 543
+ DR R + + QE +E+ + ++
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQE 1357
Score = 47.0 bits (110), Expect = 4e-05
Identities = 36/206 (17%), Positives = 93/206 (45%), Gaps = 10/206 (4%)
Query: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK-- 404
G D E+ + +D +E R + R+R E QR R + +E++ +
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 405 --EDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNE 462
E++ +++ R ++RD ++ + + +E + R R+ ++ +S ++ + +E
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE--EQLQSCKGHETEEFPDE 207
Query: 463 SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKH 522
+ + + +GR + ++ ++R+ +E+ K R +E +++ +++ +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 523 DRRRSQSIEQ----ESQEKQHKNKDE 544
R + EQ E QE + + ++E
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEE 293
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/185 (20%), Positives = 87/185 (47%), Gaps = 10/185 (5%)
Query: 225 VQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE 284
+++ +Q+ R + +K +E +R ++ R + R R+ R R
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 285 GHGSSSF--DRELEREKERQRL---EREAKER-EKERRRSRSIDRGLERRRSR---SRER 335
F + +L +E+E Q+L +R+ K R E+E+ + ++ L + R R + E+
Sbjct: 1791 QESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
++ +SR R+ ++ E+++ ER R+ ++ + + E ++ R+ +S+E +
Sbjct: 1851 FATQEKSR-REEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909
Query: 396 GEVEE 400
G + E
Sbjct: 1910 GRLLE 1914
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 111 bits (277), Expect = 2e-24
Identities = 97/290 (33%), Positives = 127/290 (43%), Gaps = 17/290 (5%)
Query: 259 RSRSPRR---SLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKER 315
RSRSP+R S SP+R P SRSR+ R G S+ R R R
Sbjct: 524 RSRSPQRRGRSRSPQR-PGWSRSRNTQRRGRSRSA---RRGRSHSRSPATRGRSRSRTPA 579
Query: 316 RRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERG 375
RR RS R RRRSRSR R RSRSR R R R + R R R + R
Sbjct: 580 RRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRS 639
Query: 376 NEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH 435
R R RSR ++ RSR ++ + R + S+ + RSRSR +
Sbjct: 640 PARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPR- 698
Query: 436 RSRSRSRNAGKRSRSRSKE--------KSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKK 487
R RSRSR+ +R RS S+ SS+ KN+S+ S +RSRS S S +
Sbjct: 699 RGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSR-TSQRRSRSNSSPEMKKSRISSR 757
Query: 488 REHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEK 537
R S S +S+ +SR R S Q + RRS+S + + K
Sbjct: 758 RSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAK 807
Score = 108 bits (270), Expect = 1e-23
Identities = 102/346 (29%), Positives = 146/346 (42%), Gaps = 39/346 (11%)
Query: 209 TKLEWFSTLFPRIPVPVQK-NIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSL 267
TK+ ++ P P P ++I + P K+ G + D+ SR RS
Sbjct: 428 TKVSRHASSSPESPKPAPAPGSHREISSSPTS--KNRSHGRAKRDKSHSHTPSRRMGRSR 485
Query: 268 SPRRSPR-RSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSR-----SI 321
SP + R RSRSR+ + GH S S + R + QR R + + R RS S
Sbjct: 486 SPATAKRGRSRSRTPTKRGH-SRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSR 544
Query: 322 DRGLERR-RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREK 380
R +RR RSRS R RS SRS +G R R R RGR R R + R R
Sbjct: 545 SRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPAR-----RGRSRSRTPARRRSRSRTP 599
Query: 381 ERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
R RSR R+ +R R + + R R ++ RSRSR R RSR
Sbjct: 600 TRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSR 659
Query: 441 SRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR 500
SR +R RSRS+ + + + RSRS + R + + R +P + +SR R
Sbjct: 660 SRTPARRGRSRSRTPARR---------SGRSRSRTPAR-----RGRSRSRTPRRGRSRSR 705
Query: 501 ---------SRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEK 537
SR+ +R + S + + +RRS+S +K
Sbjct: 706 SLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKK 751
Score = 105 bits (261), Expect = 1e-22
Identities = 92/323 (28%), Positives = 137/323 (42%), Gaps = 42/323 (13%)
Query: 258 RRSRSPRRSLSPRRSPR-RSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR 316
R++R RRS S SP RSR+ HR SS + + R+R + + R
Sbjct: 1699 RKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSR 1758
Query: 317 RSRSID---RGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGR--RRDRDYD 371
R RS RGL+R RSRSR +R RDR G + R R++ R R RR R
Sbjct: 1759 RGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGS 1818
Query: 372 ------------------KERGNEREKERERSRERSKE-----QRSRGEVEEKKHKEDKD 408
+ RG R R R RS+ +RSR H+ +
Sbjct: 1819 GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRS 1878
Query: 409 DR----RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR-SRSRSKEKSSKHKNES 463
R R R S ++ SRSR+ + RSRSR+ +R SRSR+ + +
Sbjct: 1879 RTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSR 1938
Query: 464 KEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHD 523
+ +RSRS RT V + + R +P + R RSR+ + +R S+ ++
Sbjct: 1939 TPTTRRRSRS----RTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRR----SRSRTSPVT 1990
Query: 524 RRRSQSIEQESQEKQHKNKDETV 546
RRRS+S ++ +++ V
Sbjct: 1991 RRRSRSRTSPVTRRRSRSRTSPV 2013
Score = 104 bits (259), Expect = 2e-22
Identities = 109/328 (33%), Positives = 139/328 (42%), Gaps = 54/328 (16%)
Query: 253 RHVERR-RSRSPRRSLSPRRSPR---RSRSRSHHREGHGSSSFDRELEREKERQRLEREA 308
R+ +RR RSRS RR S RSP RSRSR+ R G S R R + R R
Sbjct: 546 RNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRS---RTPARRRSRSRTPTRR 602
Query: 309 KEREKE-RRRSRSIDRGLERRRSRSRE--RHRSRS-------------------RSRDRK 346
+ R + RR RS R RRRSR+R R RSRS RSR R
Sbjct: 603 RSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRT 662
Query: 347 GDRRDRDREREKENERGRRRDRDYDKE-RGNEREKERERSRERSKEQRSR---------- 395
RR R R R GR R R + R R R RSR RS +R R
Sbjct: 663 PARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRG 722
Query: 396 --GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSK 453
G E+K+K RR R +S E K SR SR + S RS+ + S RS
Sbjct: 723 RSGSSSERKNKSRTSQRRSRS---NSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSL 779
Query: 454 EKSSKHKNESKEKSNKRSRSGS-----QGRTDSVEKSKKREHSPSKEKSRKRSRSKERSH 508
SS + + +RSRSGS + RT +S+ P K+KS+ SR +SH
Sbjct: 780 SGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPP-RRSRSSSSPPPKQKSKTPSR---QSH 835
Query: 509 KRDHSDSKDQSDKHDRRRSQSIEQESQE 536
K +S R+ S + Q +++
Sbjct: 836 SSSSPHPKVKSGTPPRQGSITSPQANEQ 863
Score = 100 bits (250), Expect = 3e-21
Identities = 91/308 (29%), Positives = 128/308 (41%), Gaps = 43/308 (13%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRL-------EREAK 309
+ +SR+P R S R SP +R R +SS R R R E K
Sbjct: 1679 KTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEK 1738
Query: 310 EREKERRRSRSI----------------DRGLERRRSRSRERHRSRSRSRDRKGDRRDRD 353
R RRRS S RGL+R RSRSR +R RDR G +
Sbjct: 1739 SRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTS 1798
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
R R +R R R R + RG R +R+ S SR + R R
Sbjct: 1799 RRR----QRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSR---RRRGRSRTPPTSRKR 1851
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRN---AGKRSRS--------RSKEKSSKHKNE 462
R S K SRSR+ HR RSRSR + +RSRS RS+ ++S +
Sbjct: 1852 SRSRTSPAPWKRSRSRASPATHR-RSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRR 1910
Query: 463 SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKH 522
S+ +++ SR S+ RT V + + R +P+ + R RSR+ + +R S + + +
Sbjct: 1911 SRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR-RSRSRTPPVTRRRSRSRTPPVTRRR 1969
Query: 523 DRRRSQSI 530
R R+ I
Sbjct: 1970 SRSRTSPI 1977
Score = 96.7 bits (239), Expect = 5e-20
Identities = 88/309 (28%), Positives = 127/309 (41%), Gaps = 38/309 (12%)
Query: 234 KTRPRKIKKDGKEGAE--EIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSF 291
+T PR + E E R RRRS S SP R+++ R G S
Sbjct: 1719 RTPPRHRRSPSVSSPEPAEKSRSSRRRRSAS-----SP-------RTKTTSRRGRSPSPK 1766
Query: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD 351
R L+R + R R E+ R ++R S + RRR RSR R R R R G
Sbjct: 1767 PRGLQRSRSRSRREKTRTTRRRDRSGS---SQSTSRRRQRSRSRSRVTRRRRGGSGYHSR 1823
Query: 352 RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKE-----QRSRGEVEEKKHKED 406
+E RRR RG R R R RS+ +RSR H+
Sbjct: 1824 SPARQESSRTSSRRR-------RGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRS 1876
Query: 407 KDD----RRHRDDKRDSKKEKKHSRSRSRERKHRSRSR-SRNAGKRSRSRSKEKSSKHKN 461
+ R R R S ++ SRSR+ + RSRSR S + +RSRSR+ + +
Sbjct: 1877 RSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSR 1936
Query: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
+ +RSRS RT V + + R +P + R RSR+ + +R S + + +
Sbjct: 1937 SRTPTTRRRSRS----RTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRR 1992
Query: 522 HDRRRSQSI 530
R R+ +
Sbjct: 1993 RSRSRTSPV 2001
Score = 86.3 bits (212), Expect = 7e-17
Identities = 88/342 (25%), Positives = 133/342 (38%), Gaps = 45/342 (13%)
Query: 229 IDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPR----RSLSPRRSPRRSRSRSHHR- 283
+D + + PR+ + ++ R R +S S ++ +PR PRRSRS S +
Sbjct: 1585 VDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKG 1644
Query: 284 ---EGHGSSSFDRELE--------REKERQRLEREAKEREKERRRSRSIDRGLER----- 327
GSSS + E R R E + K R RRRS L R
Sbjct: 1645 RGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLS 1704
Query: 328 RRSRSRERH---RSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNERE----- 379
RRSRS RSR+ R R+ EK RRR + + R
Sbjct: 1705 RRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPS 1764
Query: 380 -KERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR 438
K R R RS+ +R +K R D+ S + R RSR R +R
Sbjct: 1765 PKPRGLQRSRSRSRR------------EKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTR 1812
Query: 439 SRSRNAGKRSRSRSKEKSSK---HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE 495
R +G SRS ++++SS+ + + ++ SR S+ RT + R +
Sbjct: 1813 RRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPAT 1872
Query: 496 KSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEK 537
R RSR+ S +R S + S + R R+ + S+ +
Sbjct: 1873 HRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSR 1914
Score = 85.5 bits (210), Expect = 1e-16
Identities = 90/323 (27%), Positives = 127/323 (39%), Gaps = 36/323 (11%)
Query: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
+PR +++ E R RR +S S RR RSRSR R GS R
Sbjct: 1766 KPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSP 1825
Query: 296 EREKE----------RQRLEREAKEREKER------------------RRSRSIDRGLER 327
R++ R R +++R + R RRSRS + R
Sbjct: 1826 ARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISR 1885
Query: 328 RRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE 387
RRSRSR SR R R R R R + + RRR R R + R +
Sbjct: 1886 RRSRSRT--SPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTR 1943
Query: 388 RSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSR-SRERKHRSRSRSRNAGK 446
R R+ + R R R S ++ SRSR S + RSRSR+ +
Sbjct: 1944 RRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTR 2003
Query: 447 RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKER 506
R RSRS+ S + S+ ++ R S+ RT + + + R SP + R RSR+
Sbjct: 2004 R-RSRSR-TSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRT 2061
Query: 507 SHKRDHSDSKDQSDKHDRRRSQS 529
+ + S +S RRRS S
Sbjct: 2062 ARGK---RSLTRSPPAIRRRSAS 2081
Score = 85.1 bits (209), Expect = 1e-16
Identities = 85/294 (28%), Positives = 122/294 (41%), Gaps = 26/294 (8%)
Query: 220 RIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSR--SP----RRSLSPRRSP 273
R P ++ + TR R + R RRRSR SP RS SP R
Sbjct: 585 RSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRS 644
Query: 274 RRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKE-RRRSRSIDRGLERRRSRS 332
RSRSR+ R G S R + R R + R + RR RS R R RSRS
Sbjct: 645 GRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRS 704
Query: 333 RE---RHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERS 389
R R RS SR+ R+G R ER+ ++ +RR R + E ++SR S
Sbjct: 705 RSLVRRGRSHSRTPQRRG-RSGSSSERKNKSRTSQRRSR-------SNSSPEMKKSRISS 756
Query: 390 KEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS-RSRSRERKHRSRSRSRNAGKRS 448
+ RS K K RR K+K + RSR + +++SR +RS
Sbjct: 757 RRSRSLSS-PRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRS 815
Query: 449 RSRS------KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
RS S K K+ ++ S + + +SG+ R S+ + E S + ++
Sbjct: 816 RSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQR 869
Score = 78.6 bits (192), Expect = 1e-14
Identities = 81/301 (26%), Positives = 118/301 (39%), Gaps = 46/301 (15%)
Query: 262 SPRRSLSPRRSPRRSRSRSHHREG-----------HGSSSFDRELEREKERQRLEREAKE 310
SP R SP +SP + S H SSS + E +
Sbjct: 398 SPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSP 457
Query: 311 REKER-----RRSRSIDRGLERRRSRSR-----ERHRSRSRSRDRKGDRRDRDREREKEN 360
K R +R +S RR RSR +R RSRSR+ ++G R R + +
Sbjct: 458 TSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSR 517
Query: 361 ERGRRRDRDYDKERGNEREKERER-SRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDS 419
R + RG R +R SR R+ ++R R R R + S
Sbjct: 518 SAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGR-------------SRSARRGRSHS 564
Query: 420 KKEKKHSRSRSRERKHRSRSRSRN-AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGS--Q 476
+ RSRSR R RSRSR A +RSRSR+ + + RSR+ + +
Sbjct: 565 RSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRR 624
Query: 477 GRTDSVEKSKKREHSPSKEKSRKRSRSKER--------SHKRDHSDSKDQSDKHDRRRSQ 528
RT S + + R SP++ R RSR+ R +R S S+ + + R RS+
Sbjct: 625 SRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSR 684
Query: 529 S 529
+
Sbjct: 685 T 685
Score = 77.0 bits (188), Expect = 4e-14
Identities = 93/289 (32%), Positives = 121/289 (41%), Gaps = 34/289 (11%)
Query: 249 EEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREA 308
+E R RRR RS +P S +RSRSR+ S S + R R +
Sbjct: 1828 QESSRTSSRRRRG---RSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884
Query: 309 KEREKER------RRSRSIDRGLERRRSRSR----ERHRSRS--------RSRDRKGDRR 350
+ R + R RRSRS + RRRSRSR R RSRS RSR R R
Sbjct: 1885 RRRSRSRTSPVSRRRSRS-RTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTR 1943
Query: 351 DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDR 410
R R R R R R R R R + +R RS+ R+ +
Sbjct: 1944 RRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSR-SRTSPVTRRRSRSRTSPVT 2002
Query: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRN---AGKRSRSRSKEKSSKHKNESKEKS 467
R R R S ++ SRSR+ R RSRSR KRSRSRS + + ++ S+
Sbjct: 2003 RRRSRSRTSPVTRRRSRSRTPPAIRR-RSRSRTPLLPRKRSRSRS-PLAIRRRSRSR--- 2057
Query: 468 NKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516
R+ G + T S ++R S S S RSRS R+HS S+
Sbjct: 2058 TPRTARGKRSLTRSPPAIRRRSASGS---SSDRSRSATPPATRNHSGSR 2103
Score = 74.3 bits (181), Expect = 3e-13
Identities = 83/348 (23%), Positives = 135/348 (38%), Gaps = 43/348 (12%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEID-----RHVERRRSRSPRRSLSPRRSPRRSRSRS 280
+ ++DQ+ R ++ ++E+D ER S S S + R+P R RSRS
Sbjct: 1520 ESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRS 1579
Query: 281 HHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRS-----------IDRGLERRR 329
S S L + R E K++ + R++S R L RR
Sbjct: 1580 GSSPEVDSKS---RLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRR- 1635
Query: 330 SRSRERHRSRSRSRDRKGDRR-DRDREREKENERGRRRDRDYDKERGNEREKERERSRER 388
SR S+ R +G + E ++ RR R + + R R RS
Sbjct: 1636 --SRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRS 1693
Query: 389 SKE--------QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
S E +RSR + + R R S + + SRS SR R+ S R
Sbjct: 1694 SPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRS-SRRRRSASSPR 1752
Query: 441 SRNAGKRSRSRS------KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSK 494
++ +R RS S + S+ + E + +R RSGS T S++R+ S S+
Sbjct: 1753 TKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQST-----SRRRQRSRSR 1807
Query: 495 EKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
+ +R R H R + + RRR +S + K+ +++
Sbjct: 1808 SRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSR 1855
Score = 72.0 bits (175), Expect = 1e-12
Identities = 82/307 (26%), Positives = 120/307 (39%), Gaps = 35/307 (11%)
Query: 252 DRHVERRRSRSPRRSLSPRRS---PRRSRSRSHHREGHGSSSFDRELEREKERQRLEREA 308
D+ +++ + R S SP RS P E HG S + L Q
Sbjct: 337 DKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSP--QPLATTPLSQEPVNPP 394
Query: 309 KEREKERRRS--RSIDRGLERRRSRSR---------ERHRSRSRSRDRK----GDRRDRD 353
E R RS +S ++ + S S RH S S + G R+
Sbjct: 395 SEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREIS 454
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
+N R RD R R RS +K RSR K+ R
Sbjct: 455 SSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHS----RSRS 510
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSR-------SRSRNAGKRSRSRSKEKSSKHKNESKEK 466
R S+ ++ RSRS +R+ RSR SRSRN +R RSRS + H +
Sbjct: 511 PQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATR 570
Query: 467 SNKRSRS-GSQGRTDSVEKSKKREHSPSKEKSRKRSRS---KERSHKRDHSDSKDQSDKH 522
RSR+ +GR+ S +++R S + + R RSR+ + RS R + + ++
Sbjct: 571 GRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSP 630
Query: 523 DRRRSQS 529
RRRS+S
Sbjct: 631 VRRRSRS 637
Score = 69.7 bits (169), Expect = 6e-12
Identities = 86/308 (27%), Positives = 124/308 (40%), Gaps = 32/308 (10%)
Query: 256 ERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKER 315
ER S S + R+P RSRS + ER + + +AK R R
Sbjct: 1515 ERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLR 1574
Query: 316 RRSRS-----IDRG--LERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDR 368
+RSRS +D L RRSRS + + R + D E + R R
Sbjct: 1575 QRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPR 1634
Query: 369 DYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRS 428
+ R K R S E S S E K + R + K S+ + S
Sbjct: 1635 ---RSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSS 1691
Query: 429 RSRE---RKHRSRSRSRNAGKRSRSRSKEKSSKHKNES--------KEKSNKRSRSGSQG 477
RS RK R RSR+A +RS+ ++ S K +S++R RS S
Sbjct: 1692 RSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSP 1751
Query: 478 RTDSVEKSKKREHSPS-KEKSRKRSRSKERSHK------RDHSDSKDQSDKHDRRRSQSI 530
RT + + +R SPS K + +RSRS+ R K RD S S QS R+RS+S
Sbjct: 1752 RT---KTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGS-SQSTSRRRQRSRSR 1807
Query: 531 EQESQEKQ 538
+ ++ ++
Sbjct: 1808 SRVTRRRR 1815
Score = 66.2 bits (160), Expect = 7e-11
Identities = 57/216 (26%), Positives = 95/216 (43%), Gaps = 27/216 (12%)
Query: 302 QRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENE 361
QR REAK+ E + S+ RE SRS + +K ++ +DR R E+
Sbjct: 154 QRRAREAKQPAPEPPKPYSL----------VRESSSSRSPTPKQKKKKKKKDRGRRSESS 203
Query: 362 RGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED-------KDDRRHRD 414
RR + K++ + E E ++ + RS +S+ + ++KK K K R HR
Sbjct: 204 SPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRS 263
Query: 415 DKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474
DS SRSRSR ++ + + RS +S + E ++ +
Sbjct: 264 TSADSASSSDTSRSRSRSAAAKTHTTA------LAGRSPSPASGRRGEGDAPFSEPGTTS 317
Query: 475 SQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKR 510
+Q R S E + K+ SP ++K + + KE+S R
Sbjct: 318 TQ-RPSSPETATKQPSSPYEDKDKDK---KEKSATR 349
Score = 63.2 bits (152), Expect = 6e-10
Identities = 87/385 (22%), Positives = 141/385 (36%), Gaps = 81/385 (21%)
Query: 237 PRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELE 296
P++ ++ K+ A E + R S RS +P++ ++ + R S +R+
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKS 212
Query: 297 REKERQRLEREAKERE------KERRRSRSIDRGLERRRS-----RSRERHRSRSRSRDR 345
+K++ R E E+K+R+ K +R+S+ D+ +R RS +SR HRS S
Sbjct: 213 SKKKKHRSESESKKRKHRSPTPKSKRKSK--DKKRKRSRSTTPAPKSRRAHRSTSADSAS 270
Query: 346 KGD-RRDRDRE------------REKENERGRRRDRDYDKERGNEREKERERSRERSKEQ 392
D R R R R GRR + D +R S E + +Q
Sbjct: 271 SSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQ 330
Query: 393 RSRGEVEEKKHKEDKDDRRHRDDKRDSKK-----------EKKHSRS------------- 428
S ++ K K++K R S ++H S
Sbjct: 331 PSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEP 390
Query: 429 ---RSRERKHRSRSRSRNAGKRSRSRSKEKS---------SKHKNESKEKSNKRSRSGSQ 476
S R RS ++ K +S S E S S+H + S E GS
Sbjct: 391 VNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSH 450
Query: 477 GRTDSVEKSKKR-----------EHSPSKEKSR-------KRSRSKERS-HKRDHSDSKD 517
S SK R H+PS+ R KR RS+ R+ KR HS S+
Sbjct: 451 REISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRS 510
Query: 518 QSDKHDRRRSQSIEQESQEKQHKNK 542
+ R + S +++ +++
Sbjct: 511 PQWRRSRSAQRWGRSRSPQRRGRSR 535
Score = 62.4 bits (150), Expect = 1e-09
Identities = 85/357 (23%), Positives = 128/357 (35%), Gaps = 52/357 (14%)
Query: 237 PRKIKKDGKEGAEEIDRHVERRRSRSPRRSLS------------PRRSPRRSRSRSHH-- 282
P ++K G + I V R+P R S PR RRSRS S
Sbjct: 1388 PDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGL 1447
Query: 283 REGHG---------SSSFDRELEREKERQRLEREAKEREKE-----RRRSRSIDRGLERR 328
R+G G SS +++ R R R E ++ K R RSRS
Sbjct: 1448 RDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNN 1507
Query: 329 RSRSRERHRSRSRS--------------RDRKGDRRDRDREREKENERGRRRDRDYDKER 374
+ + +R RS S S R R G ++ D + + D D +
Sbjct: 1508 KCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDS-K 1566
Query: 375 GNEREKERERSRERSK-EQRSRGEVEEKKHK-----EDKDDRR---HRDDKRDSKKEKKH 425
R R+RSR S E S+ + ++ + E KD R DS E K
Sbjct: 1567 AKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKA 1626
Query: 426 SRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKS 485
R+ R+ RS S S+ G S +SS + + SRS + +T S
Sbjct: 1627 PAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPP 1686
Query: 486 KKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
++R S E +RK S+ +++ ++ RR E EK ++
Sbjct: 1687 RRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSR 1743
Score = 58.9 bits (141), Expect = 1e-08
Identities = 78/329 (23%), Positives = 130/329 (39%), Gaps = 32/329 (9%)
Query: 238 RKIKKDGKEGAEEIDRHVERRR-SRSPR-RSLSPRRSPRRSRSRSHHREGHGS-SSFDRE 294
+ I + G E D E + ++PR RS SP ++ + RE GS SS D++
Sbjct: 1467 KDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQK 1526
Query: 295 L-------EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS----- 342
+R + E + K + RS S + ++R+ R RSRS S
Sbjct: 1527 TVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVD 1586
Query: 343 -RDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK 401
+ R RR R + ++ R R + G++ E + R+ +RSR K
Sbjct: 1587 SKSRLSPRRSRSGSSPEVKDKPRAAPR---AQSGSDSSPEPKAPAPRALPRRSRSGSSSK 1643
Query: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461
+ + + + + +R SR +++SR +R SRS + ++
Sbjct: 1644 GRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPE-PKTKSRTPPRRRSSRSSPELTR--- 1699
Query: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
K + ++RSRS S + SPS S K RS +R S S ++
Sbjct: 1700 --KARLSRRSRSASSSPETRSRTPPRHRRSPS--VSSPEPAEKSRSSRRRRSASSPRTKT 1755
Query: 522 HDRR-RSQSIE----QESQEKQHKNKDET 545
RR RS S + Q S+ + + K T
Sbjct: 1756 TSRRGRSPSPKPRGLQRSRSRSRREKTRT 1784
Score = 51.6 bits (122), Expect = 2e-06
Identities = 64/276 (23%), Positives = 116/276 (42%), Gaps = 37/276 (13%)
Query: 285 GHGSSSF-DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
G G++ + R L + R R ER + E+E RR ++ L +R + H + R
Sbjct: 12 GSGTNGYVQRNLSLVRGR-RGERPDYKGEEELRR---LEAALVKRPNPDILDHERKRRVE 67
Query: 344 DRKGDRRDRDREREKENERGRRRDRDY-----DKERGNEREKERERSRERSKEQRSRGEV 398
R + + E+ E ++ + + + +K+ ++E R E E+
Sbjct: 68 LRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAEL 127
Query: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER------------KHRSRSRSRNAGK 446
EKK++ + D D R+R ++ + S SRS +
Sbjct: 128 NEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQ 187
Query: 447 RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP-------SKEKSRK 499
+ + + K++ + ++ S + K+S + R++S K K++ SP SK+K RK
Sbjct: 188 KKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK-KRKHRSPTPKSKRKSKDKKRK 246
Query: 500 RSRS------KERSHKRDHSDSKDQSDKHDRRRSQS 529
RSRS R+H+ +DS SD R RS+S
Sbjct: 247 RSRSTTPAPKSRRAHRSTSADSASSSDT-SRSRSRS 281
Score = 37.7 bits (86), Expect = 0.027
Identities = 53/234 (22%), Positives = 90/234 (38%), Gaps = 28/234 (11%)
Query: 337 RSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
R+ S R R+G+R D E E R +ER++ E +E
Sbjct: 21 RNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQ 80
Query: 397 EVEEKKHKEDKDDRR----HRDDKRDSKKE---------KKHSRSRSRERKHR------- 436
EE++ +E R +D K+E + H + E+K+
Sbjct: 81 GYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFG 140
Query: 437 -SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKRE----HS 491
S S + + R++E K S R S S+ T +K KK++ S
Sbjct: 141 ISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRS 200
Query: 492 PSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
S R+R +S ++ R S+SK + KH R + +++S++K+ K T
Sbjct: 201 ESSSPRRERKKSSKKKKHRSESESKKR--KH-RSPTPKSKRKSKDKKRKRSRST 251
Score = 33.9 bits (76), Expect = 0.39
Identities = 38/158 (24%), Positives = 54/158 (34%), Gaps = 32/158 (20%)
Query: 410 RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNK 469
R R + K K+ S S S S S S ++ S S S SS + S S
Sbjct: 2591 REGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPS 2650
Query: 470 RSRSGSQGRT----------------------DSVEKSKKREHSPSKEKSRKRSRSKERS 507
++ G Q DS+ S+ +SP +R R +
Sbjct: 2651 PAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPV-----ERRRPSPQP 2705
Query: 508 HKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDET 545
RD S S + RR Q +S+ HK + ET
Sbjct: 2706 SPRDQQSS---SSERGSRRGQ--RGDSRSPSHKRRRET 2738
Score = 33.5 bits (75), Expect = 0.51
Identities = 44/223 (19%), Positives = 70/223 (31%), Gaps = 7/223 (3%)
Query: 258 RRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRE-----LEREKERQRLEREAKERE 312
+ RS S S S S S S GSSS D E ++ E +R+ +
Sbjct: 2528 KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK 2587
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
+ R R + +R+ RS S S S +
Sbjct: 2588 EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
+ + + S ++ GE + ++ D R S E++ +
Sbjct: 2648 SPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSP 2707
Query: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGS 475
R +S S R G R R +S HK + S + R S
Sbjct: 2708 RDQQSSSSER--GSRRGQRGDSRSPSHKRRRETPSPRPMRHRS 2748
Score = 30.4 bits (67), Expect = 4.3
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 20/131 (15%)
Query: 419 SKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNE---------------- 462
S + K+ S S RE S RN+G + SS+ K +
Sbjct: 1311 SPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLD 1370
Query: 463 SKEKSNKRS-RSGSQGRTDSVEK---SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ 518
KE+S + S S S+ D+VEK S + S + R+ S+ERS + KD
Sbjct: 1371 MKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDG 1430
Query: 519 SDKHDRRRSQS 529
+ RRS+S
Sbjct: 1431 LPRTPSRRSRS 1441
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 110 bits (274), Expect = 4e-24
Identities = 82/248 (33%), Positives = 122/248 (49%), Gaps = 48/248 (19%)
Query: 247 GAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLER 306
G +I VE + + +R+ P R R + + E RE ERE+ER+ ER
Sbjct: 219 GYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE--------REKEREREREERER 270
Query: 307 EAKEREKERRRSRSIDRGLERRRSRSRERHRSR------SRSRDRKGDRRDRDREREKEN 360
+ + E+ER + R+ DR R+RSRSR RH SR SRSRD K R R RER +
Sbjct: 271 KRRREEEEREKERARDRE-RRKRSRSRSRHSSRTSDRRCSRSRDHK---RSRSRERRRSR 326
Query: 361 ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK 420
R RRR R +D+ R + R+R R +S++++S +HR RD +
Sbjct: 327 SRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS---------------YKHRSKSRDRE 371
Query: 421 KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN-ESKEKSNKRSRSG----- 474
+++K S+E++ R +++ K S S+EK S+ N ESKE K +G
Sbjct: 372 QDRK-----SKEKEKRGSDDKKSSVK---SGSREKQSEDTNTESKESDTKNEVNGTSEDI 423
Query: 475 -SQGRTDS 481
S+G T S
Sbjct: 424 KSEGDTQS 431
Score = 108 bits (270), Expect = 1e-23
Identities = 71/208 (34%), Positives = 105/208 (50%), Gaps = 24/208 (11%)
Query: 326 ERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
E+ R R+ E R R + K +R +R++ERE+E E R K R E E+E+ER+
Sbjct: 232 EKLRKRTEEPDRDE-RLKKEKQEREEREKEREREREERER------KRRREEEEREKERA 284
Query: 386 RERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR---------ERKHR 436
R+R + +RSR D+ R RD KR +E++ SRSR R ERKHR
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
SRSR R +RS+SR + KS KH+++S+++ R + R +KS + S K+
Sbjct: 345 SRSRDR---RRSKSRDR-KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 497 SRKRSRSKERSHKRD----HSDSKDQSD 520
+ SKE K + D K + D
Sbjct: 401 EDTNTESKESDTKNEVNGTSEDIKSEGD 428
Score = 102 bits (253), Expect = 1e-21
Identities = 68/212 (32%), Positives = 108/212 (50%), Gaps = 12/212 (5%)
Query: 334 ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
++H ++ + + +++ R+R +E +R R ++ K+ EREKERER RE + +R
Sbjct: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKE--KQEREEREKEREREREERERKR 272
Query: 394 SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGKRSRSRS 452
R E E +K + +RR R R + R SR R H RSRSR R +RSRSR
Sbjct: 273 RREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER---RRSRSRD 329
Query: 453 KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDH 512
+ +S H ++S ++ RS S+ R S + +K SK + R++ R + KR
Sbjct: 330 RRRSRSH-----DRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG- 383
Query: 513 SDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
SD K S K R QS + ++ K+ K+E
Sbjct: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
Score = 95.9 bits (237), Expect = 8e-20
Identities = 68/227 (29%), Positives = 108/227 (47%), Gaps = 23/227 (10%)
Query: 232 QIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRS-PRRSRSRSHHREGHGSSS 290
+IK ++K+ ++ EE DR ++ + R R R R R RE
Sbjct: 222 KIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE------ 275
Query: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR---KG 347
E EREKER R + + R++ R RSR R +RR SRSR+ RSRSR R R +
Sbjct: 276 ---EEEREKERAR---DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD 329
Query: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407
RR R +R + R R RDR K R + K R +SR+R ++++S+ +K K
Sbjct: 330 RRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK-----EKEKRGS 384
Query: 408 DDRRH--RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS 452
DD++ + R+ + E ++ S+ + K+ S + ++S
Sbjct: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
Score = 93.2 bits (230), Expect = 5e-19
Identities = 59/174 (33%), Positives = 90/174 (51%), Gaps = 6/174 (3%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
D+++K ++ ++ KE E + ER+R R R R R RS R H S
Sbjct: 244 DERLKKEKQEREEREKEREREREER-ERKRRREEEEREKERARDRERRKRSRSRSRHSSR 302
Query: 290 SFDRELEREKE--RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRK 346
+ DR R ++ R R + R ++RRRSRS DR + RSRSR+R RS+SR R K
Sbjct: 303 TSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYK 362
Query: 347 GDRRDRDREREKENERGRRRDRDYDKE--RGNEREKERERSRERSKEQRSRGEV 398
+ RDRE++++++ +R D K + REK+ E + SKE ++ EV
Sbjct: 363 HRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEV 416
Score = 88.6 bits (218), Expect = 1e-17
Identities = 75/249 (30%), Positives = 113/249 (45%), Gaps = 24/249 (9%)
Query: 179 ESFLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTL-FPRIPVPVQKNIDQQIKTRP 237
ESF E+ ++V G + +G+ L + + +I V++ + ++++ R
Sbjct: 180 ESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEE-LKEKLRKRT 238
Query: 238 RKIKKDG---KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRE 294
+ +D KE E +R ER R R R R R + R+ RE S R
Sbjct: 239 EEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRS---RS 295
Query: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRKGDRRDRD 353
R R R ++ R+ +R RSR ERRRSRSR+R RSRS R +RK R RD
Sbjct: 296 RSRHSSRTSDRRCSRSRDHKRSRSR------ERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
R R K RDR K R R++E++R +SKE+ RG ++K + +
Sbjct: 350 RRRSKS------RDRKSYKHRSKSRDREQDR---KSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 414 DDKRDSKKE 422
+D KE
Sbjct: 401 EDTNTESKE 409
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 25/154 (16%)
Query: 408 DDRRHRDDKRDSKKEKKHSRSRS--RERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKE 465
D + DD K+ +++ ++ E K + R R+ + R K K + E +E
Sbjct: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERL----KKEKQEREERE 258
Query: 466 KSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS----------------HK 509
K +R R + + E+ +++E + +E+ R RS+ RS HK
Sbjct: 259 KEREREREERERKRRREEEEREKERARDRER---RKRSRSRSRHSSRTSDRRCSRSRDHK 315
Query: 510 RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
R S + +S DRRRS+S ++ ++ + +++D
Sbjct: 316 RSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
>gi|19923485 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 110 bits (274), Expect = 4e-24
Identities = 82/248 (33%), Positives = 122/248 (49%), Gaps = 48/248 (19%)
Query: 247 GAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLER 306
G +I VE + + +R+ P R R + + E RE ERE+ER+ ER
Sbjct: 219 GYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE--------REKEREREREERER 270
Query: 307 EAKEREKERRRSRSIDRGLERRRSRSRERHRSR------SRSRDRKGDRRDRDREREKEN 360
+ + E+ER + R+ DR R+RSRSR RH SR SRSRD K R R RER +
Sbjct: 271 KRRREEEEREKERARDRE-RRKRSRSRSRHSSRTSDRRCSRSRDHK---RSRSRERRRSR 326
Query: 361 ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK 420
R RRR R +D+ R + R+R R +S++++S +HR RD +
Sbjct: 327 SRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS---------------YKHRSKSRDRE 371
Query: 421 KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN-ESKEKSNKRSRSG----- 474
+++K S+E++ R +++ K S S+EK S+ N ESKE K +G
Sbjct: 372 QDRK-----SKEKEKRGSDDKKSSVK---SGSREKQSEDTNTESKESDTKNEVNGTSEDI 423
Query: 475 -SQGRTDS 481
S+G T S
Sbjct: 424 KSEGDTQS 431
Score = 108 bits (270), Expect = 1e-23
Identities = 71/208 (34%), Positives = 105/208 (50%), Gaps = 24/208 (11%)
Query: 326 ERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
E+ R R+ E R R + K +R +R++ERE+E E R K R E E+E+ER+
Sbjct: 232 EKLRKRTEEPDRDE-RLKKEKQEREEREKEREREREERER------KRRREEEEREKERA 284
Query: 386 RERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR---------ERKHR 436
R+R + +RSR D+ R RD KR +E++ SRSR R ERKHR
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
SRSR R +RS+SR + KS KH+++S+++ R + R +KS + S K+
Sbjct: 345 SRSRDR---RRSKSRDR-KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 497 SRKRSRSKERSHKRD----HSDSKDQSD 520
+ SKE K + D K + D
Sbjct: 401 EDTNTESKESDTKNEVNGTSEDIKSEGD 428
Score = 102 bits (253), Expect = 1e-21
Identities = 68/212 (32%), Positives = 108/212 (50%), Gaps = 12/212 (5%)
Query: 334 ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
++H ++ + + +++ R+R +E +R R ++ K+ EREKERER RE + +R
Sbjct: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKE--KQEREEREKEREREREERERKR 272
Query: 394 SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGKRSRSRS 452
R E E +K + +RR R R + R SR R H RSRSR R +RSRSR
Sbjct: 273 RREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER---RRSRSRD 329
Query: 453 KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDH 512
+ +S H ++S ++ RS S+ R S + +K SK + R++ R + KR
Sbjct: 330 RRRSRSH-----DRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG- 383
Query: 513 SDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
SD K S K R QS + ++ K+ K+E
Sbjct: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
Score = 95.9 bits (237), Expect = 8e-20
Identities = 68/227 (29%), Positives = 108/227 (47%), Gaps = 23/227 (10%)
Query: 232 QIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRS-PRRSRSRSHHREGHGSSS 290
+IK ++K+ ++ EE DR ++ + R R R R R RE
Sbjct: 222 KIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE------ 275
Query: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR---KG 347
E EREKER R + + R++ R RSR R +RR SRSR+ RSRSR R R +
Sbjct: 276 ---EEEREKERAR---DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD 329
Query: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407
RR R +R + R R RDR K R + K R +SR+R ++++S+ +K K
Sbjct: 330 RRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK-----EKEKRGS 384
Query: 408 DDRRH--RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS 452
DD++ + R+ + E ++ S+ + K+ S + ++S
Sbjct: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
Score = 93.2 bits (230), Expect = 5e-19
Identities = 59/174 (33%), Positives = 90/174 (51%), Gaps = 6/174 (3%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
D+++K ++ ++ KE E + ER+R R R R R RS R H S
Sbjct: 244 DERLKKEKQEREEREKEREREREER-ERKRRREEEEREKERARDRERRKRSRSRSRHSSR 302
Query: 290 SFDRELEREKE--RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRK 346
+ DR R ++ R R + R ++RRRSRS DR + RSRSR+R RS+SR R K
Sbjct: 303 TSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYK 362
Query: 347 GDRRDRDREREKENERGRRRDRDYDKE--RGNEREKERERSRERSKEQRSRGEV 398
+ RDRE++++++ +R D K + REK+ E + SKE ++ EV
Sbjct: 363 HRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEV 416
Score = 88.6 bits (218), Expect = 1e-17
Identities = 75/249 (30%), Positives = 113/249 (45%), Gaps = 24/249 (9%)
Query: 179 ESFLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTL-FPRIPVPVQKNIDQQIKTRP 237
ESF E+ ++V G + +G+ L + + +I V++ + ++++ R
Sbjct: 180 ESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEE-LKEKLRKRT 238
Query: 238 RKIKKDG---KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRE 294
+ +D KE E +R ER R R R R R + R+ RE S R
Sbjct: 239 EEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRS---RS 295
Query: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRKGDRRDRD 353
R R R ++ R+ +R RSR ERRRSRSR+R RSRS R +RK R RD
Sbjct: 296 RSRHSSRTSDRRCSRSRDHKRSRSR------ERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
R R K RDR K R R++E++R +SKE+ RG ++K + +
Sbjct: 350 RRRSKS------RDRKSYKHRSKSRDREQDR---KSKEKEKRGSDDKKSSVKSGSREKQS 400
Query: 414 DDKRDSKKE 422
+D KE
Sbjct: 401 EDTNTESKE 409
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 25/154 (16%)
Query: 408 DDRRHRDDKRDSKKEKKHSRSRS--RERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKE 465
D + DD K+ +++ ++ E K + R R+ + R K K + E +E
Sbjct: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERL----KKEKQEREERE 258
Query: 466 KSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS----------------HK 509
K +R R + + E+ +++E + +E+ R RS+ RS HK
Sbjct: 259 KEREREREERERKRRREEEEREKERARDRER---RKRSRSRSRHSSRTSDRRCSRSRDHK 315
Query: 510 RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
R S + +S DRRRS+S ++ ++ + +++D
Sbjct: 316 RSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 102 bits (253), Expect = 1e-21
Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 23/240 (9%)
Query: 271 RSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRS 330
R R R RS R GS S R ++ ++ +R ++ R+++RRR RS R R RS
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRS 62
Query: 331 RSRER-HRSRSRSRDRKGDR---RDRDREREKENERGRRRDRDYDKERGNEREKERERSR 386
R R+R RSRSR RDR +R R RDR R + RGR R GN+ +K RSR
Sbjct: 63 RDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGR---RSRSSSPGNKSKKTENRSR 119
Query: 387 ERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK 446
+ K E+KK K+DK+D + +D + + + + +ER + R +
Sbjct: 120 SKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWR-------E 172
Query: 447 RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSK-EKSRKRSRSKE 505
R ++ E + K E +E QG+ S+E E P++ EK +E
Sbjct: 173 EQRKKAMENIGELKKEIEEM--------KQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEE 224
Score = 99.4 bits (246), Expect = 8e-21
Identities = 80/249 (32%), Positives = 117/249 (46%), Gaps = 41/249 (16%)
Query: 311 REKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDY 370
RE R RS RG RS SR R RS S R ++GD R R R RDRD
Sbjct: 3 RESRHYRKRSASRG----RSGSRSRSRSPSDKRSKRGDDR-----------RSRSRDRDR 47
Query: 371 DKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS 430
+ER R+K R RSR+R + +RSR ++ R R+ +R ++++ SRSRS
Sbjct: 48 RRERSRSRDKRRSRSRDRKRLRRSR----------SRERDRSRERRRSRSRDRRRSRSRS 97
Query: 431 RERKHRSRSRSRNAGK-RSRSRSKEK-----SSKHKNESKE--KSNKRSRSGSQGRTDSV 482
R R+ RS S + K +RSRSKEK SSK K + K+ + K +G+ +
Sbjct: 98 RGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLE 157
Query: 483 EKSKKREHSPSK--EKSRKRSRSKERSHKRDHSDSKD------QSDKHDRRRSQSIEQES 534
E+ +KR+ K E+ RK++ K++ + K + D D E+E
Sbjct: 158 EEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEG 217
Query: 535 QEKQHKNKD 543
E + + D
Sbjct: 218 NEMEGEELD 226
Score = 84.3 bits (207), Expect = 3e-16
Identities = 63/174 (36%), Positives = 97/174 (55%), Gaps = 17/174 (9%)
Query: 375 GNEREKERERSRERSKE-QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER 433
G E R+RS R + RSR K + DDRR R RD ++E RSRSR++
Sbjct: 2 GRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRE----RSRSRDK 57
Query: 434 KHRSRSRSRNAGKRSRSRSKEKS-SKHKNESKEKSNKRSRSGSQGR----TDSVEKSKKR 488
+ RSRSR+ + RSRS+E+ S+ + S+ + +RSRS S+GR + KSKK
Sbjct: 58 R---RSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKT 114
Query: 489 EH-SPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQS-IEQESQEKQHK 540
E+ S SKEK+ SKE+ K+D D +D+ +K Q+ +E+E ++++ +
Sbjct: 115 ENRSRSKEKTDGGESSKEK--KKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKER 166
Score = 60.5 bits (145), Expect = 4e-09
Identities = 42/139 (30%), Positives = 71/139 (51%), Gaps = 17/139 (12%)
Query: 421 KEKKHSRSRSRER-KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRT 479
+E +H R RS R + SRSRSR+ + R ++ S+ ++ + + RSR + R+
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRS 62
Query: 480 DS---VEKSKKREHSPSKEKSRKRSRSKERSH-------KRDHSDSKDQSDKHDRRRSQS 529
+ +S+ RE S+E R+RSRS++R +R S S K RS+S
Sbjct: 63 RDRKRLRRSRSRERDRSRE--RRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRS 120
Query: 530 IEQ----ESQEKQHKNKDE 544
E+ ES +++ K+KD+
Sbjct: 121 KEKTDGGESSKEKKKDKDD 139
>gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo
sapiens]
Length = 437
Score = 101 bits (251), Expect = 2e-21
Identities = 78/220 (35%), Positives = 109/220 (49%), Gaps = 30/220 (13%)
Query: 270 RRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRR 329
R S R SR R G S R+ +R++ER+R ER ++ER+KER ERRR
Sbjct: 209 RHSGRDDTSRYDERPGP-SPLPHRDRDRDRERERRER-SRERDKER----------ERRR 256
Query: 330 SRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERS 389
SRSR+R R RSRSRD++ RR R+R ++K+ +R RR R ++ R R RER
Sbjct: 257 SRSRDRRR-RSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERAR---------RERERK 306
Query: 390 KEQRSRG-EVEEKKHKEDK--DDRRHRD---DKRDSKKEKKHSRSRSRERKHRSRSRSRN 443
+E R G ++ E D DD + D D +EK R R R R HRS R
Sbjct: 307 EELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRR 366
Query: 444 AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
R R R +++ K E+ +R G G+ + +E
Sbjct: 367 --DRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLE 404
Score = 84.0 bits (206), Expect = 3e-16
Identities = 65/220 (29%), Positives = 99/220 (45%), Gaps = 31/220 (14%)
Query: 317 RSRSIDRGLERRRSRSRE---RHRSR---SRSRDRKGD----RRDRDREREKENERGRRR 366
R R + GL R + RH R SR +R G RDRDR+RE+E
Sbjct: 188 RPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERER------ 241
Query: 367 DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS 426
+ER ER+KERER R RS+++R R +K+ + RR R+ +D +++K
Sbjct: 242 -----RERSRERDKERERRRSRSRDRRRRSRSRDKEER-----RRSRERSKDKDRDRKRR 291
Query: 427 RSRSRERKHRSRSRS---RNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
SRSRER R R R R G S+ + + + G + + +
Sbjct: 292 SSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRD 351
Query: 484 KSKKREHSPSKEK--SRKRSRSKERSHKRDHSDSKDQSDK 521
+ ++R H +E+ R R R ++R HKR S+ D+
Sbjct: 352 RERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDE 391
Score = 77.0 bits (188), Expect = 4e-14
Identities = 61/254 (24%), Positives = 102/254 (40%), Gaps = 26/254 (10%)
Query: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRD 353
E E E++ + A ++ + RR ++ R R+ + R R G RR
Sbjct: 150 EYEHERDMHSAYKHADGKKIDGRRVL-----VDVERGRTVKGWRPRRLGGGLGGTRRGGA 204
Query: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
+ + GR YD+ G R+R R+R +E+R E+ + DK+ R R
Sbjct: 205 DVNIRHS--GRDDTSRYDERPGPSPLPHRDRDRDRERERR------ERSRERDKERERRR 256
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
RD ++ SRSR +E + RSR RS++ + + RS + + E + K R
Sbjct: 257 SRSRD---RRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGG 313
Query: 474 GSQGRTDSVEKSKKREHSPS----------KEKSRKRSRSKERSHKRDHSDSKDQSDKHD 523
G + + P +EK R R R + RSH+ + +D+ D
Sbjct: 314 GDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDRD 373
Query: 524 RRRSQSIEQESQEK 537
R R + E+
Sbjct: 374 RDREHKRGERGSER 387
Score = 74.7 bits (182), Expect = 2e-13
Identities = 61/188 (32%), Positives = 79/188 (42%), Gaps = 24/188 (12%)
Query: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293
+ R R +++ +E + E D+ ERRRSRS R R + R RS R R
Sbjct: 231 RDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKR 290
Query: 294 ELEREKERQRLEREAKER---------EKERRRSRSIDRG-------------LERRRSR 331
R +ER R ERE KE E D G E+ R R
Sbjct: 291 RSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDR 350
Query: 332 SRERHRSRSRSRDRKGDR-RDRDRERE-KENERGRRRDRDYDKERGNEREKERERSRERS 389
RER RS R+R+ DR RDRDR+RE K ERG R RD + G ++ E S
Sbjct: 351 DRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGGGGGQDNGLEGLGNDS 410
Query: 390 KEQRSRGE 397
++ E
Sbjct: 411 RDMYMESE 418
Score = 72.8 bits (177), Expect = 8e-13
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 26/182 (14%)
Query: 254 HVERRRSRS-PRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
H +R R R RR S R R R RS R++ R+ R+ +ER
Sbjct: 230 HRDRDRDRERERRERSRERDKERERRRSR--------------SRDRRRRSRSRDKEERR 275
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRD--- 369
+ R RS+ DR +RR SRSRER R R R+RK + R + + +E G D
Sbjct: 276 RSRERSKDKDRDRKRRSSRSRERAR---RERERKEELRGGGGDMAEPSEAGDAPPDDGPP 332
Query: 370 ----YDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKH 425
D G E EK R+R RER + RS E + ++ DR H+ +R S++ +
Sbjct: 333 GELGPDGPDGPE-EKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDE 391
Query: 426 SR 427
+R
Sbjct: 392 AR 393
Score = 48.1 bits (113), Expect = 2e-05
Identities = 64/283 (22%), Positives = 117/283 (41%), Gaps = 28/283 (9%)
Query: 281 HHREGH-GSSSFDRELEREKERQRLER-EAKEREKERRRSRSIDRGLERRRSRSR--ERH 336
HH + + G + + RE E ++ R E +E ER+R I+R + + + + H
Sbjct: 33 HHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVETELKMWDPH 92
Query: 337 RSRSRSRDR---------KGDRRDRDREREKENERGRRR-DRDYDKERGNER-----EKE 381
+ D D + RE E +R Y K G R E E
Sbjct: 93 NDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPRGYAFIEYE 152
Query: 382 RERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRS 441
ER + + +++ ++ D + R R K + ++ R+ +
Sbjct: 153 HERDMHSAYKHADGKKIDGRRVLVDVE--RGRTVK--GWRPRRLGGGLGGTRRGGADVNI 208
Query: 442 RNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS-RKR 500
R++G+ SR E+ +++ R R + R S E+ K+RE S+ + R+R
Sbjct: 209 RHSGRDDTSRYDERPGPSPLPHRDRDRDRER---ERRERSRERDKERERRRSRSRDRRRR 265
Query: 501 SRSKER-SHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
SRS+++ +R SKD+ RR S+S E+ +E++ K +
Sbjct: 266 SRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEE 308
Score = 34.7 bits (78), Expect = 0.23
Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 5/73 (6%)
Query: 477 GRTDSVEKSKKREHSPSKEKSRKRSRSKER---SHKRDHSDSKDQSDKHD-RRRSQSIEQ 532
GR D+ ++ SP + R R R +ER S +RD + +S D RRRS+S ++
Sbjct: 212 GRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDK 271
Query: 533 ESQEK-QHKNKDE 544
E + + + ++KD+
Sbjct: 272 EERRRSRERSKDK 284
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 101 bits (251), Expect = 2e-21
Identities = 63/244 (25%), Positives = 122/244 (50%), Gaps = 15/244 (6%)
Query: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
+ E++R R ++R+++R+ S S DR R R R R RSRSRSR + +R R +E
Sbjct: 17 KEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKE 76
Query: 356 REKENERGR-RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD 414
RE++ ER R ++DRD DK+ G+ R+K+R+RS S G ++ K ++D+D ++ +
Sbjct: 77 RERDKERDRNKKDRDRDKD-GHRRDKDRKRS------SLSPGRGKDFKSRKDRDSKKDEE 129
Query: 415 DKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474
D+ KK K S + A + S+++ ++ K +E ++
Sbjct: 130 DEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQ---- 185
Query: 475 SQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQES 534
R E+ K+++ K + + +ER +R+ + + ++ + R + E++
Sbjct: 186 ---RMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKD 242
Query: 535 QEKQ 538
+ K+
Sbjct: 243 KSKE 246
Score = 90.1 bits (222), Expect = 5e-18
Identities = 73/271 (26%), Positives = 122/271 (45%), Gaps = 28/271 (10%)
Query: 239 KIKKDGKEGAEEIDRH--VERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELE 296
K +D EE R +R R R R SP + +R RSR R G S S R
Sbjct: 8 KKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKS 67
Query: 297 REKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356
E+ER+ ER ER+KER R++ + R RD+ G RRD+DR+R
Sbjct: 68 AERERRHKER---ERDKERDRNK-------------------KDRDRDKDGHRRDKDRKR 105
Query: 357 EKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDK 416
+ GR +D K+R +++++E E ++ K Q +EE K+ ++ K
Sbjct: 106 SSLSP-GRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPL--SLEELLAKKKAEEEAEAKPK 162
Query: 417 RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQ 476
SK E++ + R+++ R R ++ R + ++ K + +E+ + R +
Sbjct: 163 FLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERME 222
Query: 477 GRTDSVEKSKKREH-SPSKEKSRKRSRSKER 506
T+ E + R+ K+KS++ KER
Sbjct: 223 RETNGNEDEEGRQKIREEKDKSKELHAIKER 253
Score = 87.0 bits (214), Expect = 4e-17
Identities = 67/234 (28%), Positives = 119/234 (50%), Gaps = 32/234 (13%)
Query: 326 ERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
+R S S+E R RSR+ DR+ RDRDR+R+ + R+R R D+ RG R + R RS
Sbjct: 10 DRDASPSKEE-RKRSRTPDRE---RDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRS 65
Query: 386 RERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAG 445
+ +E+R HKE + D+ +K+D ++K R R ++RK S S R G
Sbjct: 66 KSAERERR---------HKERERDKERDRNKKDRDRDKDGHR-RDKDRKRSSLSPGR--G 113
Query: 446 KRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKE 505
K +SR K++ SK K+E E +K+ ++ + + K K E + +K K ++ +
Sbjct: 114 KDFKSR-KDRDSK-KDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREA 171
Query: 506 RSHKRDHSDSKD-----QSDKHDRRRSQSI---------EQESQEKQHKNKDET 545
+ KR + ++ + ++ R++ Q + E+E +E++ + + ET
Sbjct: 172 EALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERET 225
Score = 73.2 bits (178), Expect = 6e-13
Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 17/168 (10%)
Query: 377 EREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR 436
E +++R SKE+R R R D +RD +++K S S+ R+R HR
Sbjct: 4 ELADKKDRDASPSKEERKRS--------------RTPDRERDRDRDRKSSPSKDRKR-HR 48
Query: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496
SR R R G RSRSRS+ KS++ + KE+ + R ++ D +K R K
Sbjct: 49 SRDR-RRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDR-DKDGHRRDKDRKRS 106
Query: 497 SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
S R K+ ++D KD+ D+H ++ ++ +E K K E
Sbjct: 107 SLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAE 154
Score = 55.8 bits (133), Expect = 1e-07
Identities = 61/299 (20%), Positives = 126/299 (42%), Gaps = 36/299 (12%)
Query: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSP----RRSR-SRSHHRE 284
+++ K R R ++D + + D+ RR R SLSP R R+ R S+ +
Sbjct: 71 ERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEED 130
Query: 285 GHGSSSFDRE---LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR 341
HG + LE +++ E EA+ + K ++ L+RR+ ER R
Sbjct: 131 EHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEE 190
Query: 342 SRDRKG-----------DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSK 390
R ++ D ++R+R RR+R + GNE E+ R++ RE
Sbjct: 191 ERKKRKQFQDLGRKMLEDPQERERR--------ERRERMERETNGNEDEEGRQKIREEKD 242
Query: 391 EQRSRGEVEEKKHKEDKDDR--RHRDDKR-----DSKKEKKHSRSRSRERKHRSRSRSRN 443
+ + ++E+ K R RH +D++ D+ ++ + + +H+ + R
Sbjct: 243 KSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRG 302
Query: 444 --AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR 500
AG + + +E+S + + +++ + + R + K + ++ + S+K+
Sbjct: 303 FIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKK 361
Score = 46.2 bits (108), Expect = 8e-05
Identities = 56/248 (22%), Positives = 99/248 (39%), Gaps = 39/248 (15%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREG 285
+K +++ + +P+ + K +E AE + R + R +R L R R+ G
Sbjct: 150 KKKAEEEAEAKPKFLSKAERE-AEALKRRQQEVEER--QRMLEEERKKRKQ----FQDLG 202
Query: 286 HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS--- 342
+E ER + R+R+ERE E E R + + + +S+E H + R
Sbjct: 203 RKMLEDPQERERRERRERMERETNGNEDEEGRQK-----IREEKDKSKELHAIKERYLGG 257
Query: 343 -RDRKGDRRDRDREREKENERGRRRDRDYD---KERGNE-------------REKERERS 385
+ R+ R DR+ E + DY+ KER ++++RE+S
Sbjct: 258 IKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQS 317
Query: 386 RERSKEQRSRGEVEEKKHKE-------DKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSR 438
R R +EEK+ +E K+ ++ DD+ S+K+ R
Sbjct: 318 RFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDY 377
Query: 439 SRSRNAGK 446
S + GK
Sbjct: 378 SITTKGGK 385
Score = 43.5 bits (101), Expect = 5e-04
Identities = 24/106 (22%), Positives = 47/106 (44%), Gaps = 8/106 (7%)
Query: 444 AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRS 503
AG+ + + ++ S + + ++ R R + R S K +KR S + + RSRS
Sbjct: 2 AGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRS 61
Query: 504 K--------ERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541
+ ER HK D + +K DR R + + ++++ +
Sbjct: 62 RSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSS 107
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 100 bits (249), Expect = 3e-21
Identities = 82/254 (32%), Positives = 124/254 (48%), Gaps = 28/254 (11%)
Query: 288 SSSFDRELEREKERQRLEREAKE---REKERRRSRSIDRGLERRRSRSRERHRSRSRSRD 344
S + ++R +E Q L A E +E++RR SRS R RRR+ S RHR RSRSR
Sbjct: 216 SKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRS-RRRRTPSSSRHR-RSRSRS 273
Query: 345 RKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404
R RR + R + + RR R + +ERG RSR SK + K K
Sbjct: 274 R---RRSHSKSRSRRRSKSPRRRRSHSRERG-------RRSRSTSKTR--------DKKK 315
Query: 405 EDKDDRRHRDDKRDSKKEKKHSRSRSRE-RKHRSRSRSRNAGK-RSRSRSKEKSSKHKNE 462
EDK+ +R + + S + SRS SRE R+ RSRS +R+ K RS R +S +
Sbjct: 316 EDKEKKRSKTPPK-SYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRH 374
Query: 463 SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKH 522
KEK K+ + + R + + K++ S KEK R+R ++ K+ D ++ +
Sbjct: 375 KKEK--KKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGY 432
Query: 523 DRRRSQSIEQESQE 536
D + + E++ E
Sbjct: 433 DSEKEKKEEKKPIE 446
Score = 98.2 bits (243), Expect = 2e-20
Identities = 81/250 (32%), Positives = 114/250 (45%), Gaps = 26/250 (10%)
Query: 270 RRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRR 329
+R RSRSRS R SS + R R R + + + RRRS+S RRR
Sbjct: 245 KRRHSRSRSRSRRRRTPSSS------RHRRSRSRSRRRSHSKSRSRRRSKSP----RRRR 294
Query: 330 SRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERS 389
S SRER R RSRS + D++ D KE +R + + Y R + R SRER
Sbjct: 295 SHSRERGR-RSRSTSKTRDKKKED----KEKKRSKTPPKSYSTAR-----RSRSASRERR 344
Query: 390 KEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSR 449
+ + G KK + K R KKEKK + + R R R RS S+ K+S+
Sbjct: 345 RRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKK--KKSK 402
Query: 450 SRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK 509
+ K++ K +++ K R + DS EK KK E P + S K +KE S +
Sbjct: 403 DKEKDRERKSESDKDVKQVTRDYDEEEQGYDS-EKEKKEEKKPIETGSPK---TKECSVE 458
Query: 510 RDHSDSKDQS 519
+ DS +S
Sbjct: 459 KGTGDSLRES 468
Score = 97.1 bits (240), Expect = 4e-20
Identities = 72/256 (28%), Positives = 121/256 (47%), Gaps = 12/256 (4%)
Query: 221 IPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRS-- 278
I ++ + ++ + R + + RH R RSRS RRS S RS RRS+S
Sbjct: 233 ISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRH-RRSRSRSRRRSHSKSRSRRRSKSPR 291
Query: 279 --RSHHREG---HGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSR 333
RSH RE S+S R+ ++E + ++ + + RRSRS R RRRSRS
Sbjct: 292 RRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSG 351
Query: 334 ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393
R + RS RK R R +KE ++ + ++R D+ + +K++ + +E+ +E++
Sbjct: 352 TRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERK 411
Query: 394 SRGEVEEKKHKEDKDDRRH-RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS 452
S + + K+ D D+ D +++ K+EKK + S + K S + R S
Sbjct: 412 SESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLR---ES 468
Query: 453 KEKSSKHKNESKEKSN 468
K H E + S+
Sbjct: 469 KVNGDDHHEEDMDMSD 484
Score = 95.5 bits (236), Expect = 1e-19
Identities = 76/246 (30%), Positives = 116/246 (47%), Gaps = 27/246 (10%)
Query: 249 EEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREA 308
EE RH R RSRS RR RRSRSRS R S S R R K +R +
Sbjct: 243 EEKRRH-SRSRSRSRRRRTPSSSRHRRSRSRSRRR----SHSKSRSRRRSKSPRRRRSHS 297
Query: 309 KEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDR 368
+ER RRSRS + ++++ +E+ RS++ + RR R RE+ R R R
Sbjct: 298 RERG---RRSRSTSKTRDKKKE-DKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTR 353
Query: 369 DYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRS 428
K R +R+ R S R K K+ K+DKD R RD++ S +KK S+
Sbjct: 354 SPKKPRSPKRKLSRSPSPRRHK----------KEKKKDKDKERSRDERERSTSKKKKSKD 403
Query: 429 RSRERKHRSRSR------SRNAGKRSRSRSKEKSSKHKNESKEKSNKRSR--SGSQGRTD 480
+ ++R+ +S S +R+ + + EK K + + E + +++ S +G D
Sbjct: 404 KEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGD 463
Query: 481 SVEKSK 486
S+ +SK
Sbjct: 464 SLRESK 469
Score = 91.7 bits (226), Expect = 2e-18
Identities = 66/246 (26%), Positives = 113/246 (45%), Gaps = 22/246 (8%)
Query: 306 REAKEREKERRRSRS-IDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGR 364
+E +E K R ++S I +E + + RH SRSRSR R R R + R R
Sbjct: 217 KEIEEAMKRVREAQSLISAAIEPDKKEEKRRH-SRSRSRSR--------RRRTPSSSRHR 267
Query: 365 RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKK 424
R + R R + RSR RSK R R ++ + + + RD K++ K++K
Sbjct: 268 R-----SRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKK- 321
Query: 425 HSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEK 484
RS++ + + + RSR+A + R R ++ + + K SRS S R +K
Sbjct: 322 --RSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKK 379
Query: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQ----EKQHK 540
K + E+ R S+ K+ K + K +SDK ++ ++ ++E Q EK+ K
Sbjct: 380 KDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKK 439
Query: 541 NKDETV 546
+ + +
Sbjct: 440 EEKKPI 445
Score = 76.6 bits (187), Expect = 5e-14
Identities = 58/179 (32%), Positives = 90/179 (50%), Gaps = 13/179 (7%)
Query: 374 RGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRER 433
+ + KE E + +R +E +S + + DK + + R + S+ ++ + S SR R
Sbjct: 211 KSDTSSKEIEEAMKRVREAQS---LISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHR 267
Query: 434 KHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE-KSKKREHSP 492
+ RSRSR R+ K SRSR + KS + + + +RSRS S+ R E K KKR +P
Sbjct: 268 RSRSRSRRRSHSK-SRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTP 326
Query: 493 SKE-----KSRKRSRSKERSHKRD--HSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
K +SR SR + R R S K +S K RS S + +EK+ K+KD+
Sbjct: 327 PKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKK-KDKDK 384
Score = 40.0 bits (92), Expect = 0.005
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 12/112 (10%)
Query: 444 AGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR-S- 501
AG S S + SSK E+ ++ + ++S + +K +KR HS S+ +SR+R +
Sbjct: 203 AGLVSPSLKSDTSSKEIEEAMKRV-REAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTP 261
Query: 502 ------RSKERSHKRDHSDSKD--QSDKHDRRRSQSIEQESQEKQ-HKNKDE 544
RS+ RS +R HS S+ +S RRRS S E+ + + K +D+
Sbjct: 262 SSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDK 313
>gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo
sapiens]
Length = 375
Score = 100 bits (248), Expect = 4e-21
Identities = 72/233 (30%), Positives = 107/233 (45%), Gaps = 36/233 (15%)
Query: 283 REGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS 342
++G S D+ ++ K + ++E +K R R S + G +R + + R+ R RS S
Sbjct: 9 KQGRRHESKDKSSKKHKSEEHNDKEHSS-DKGRERLNSSENGEDRHKRKERKSSRGRSHS 67
Query: 343 RDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKK 402
R R +RR R R RE++ R R R+R + R ER+K R RSRER + RSR
Sbjct: 68 RSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSR------- 120
Query: 403 HKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS-SKHKN 461
SRSRSR R HR+RSRSR RSRSR ++K K +
Sbjct: 121 -----------------------SRSRSRHR-HRTRSRSRT---RSRSRDRKKRIEKPRR 153
Query: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSD 514
S+ S S +GR +++ + + K + R KE K+ +
Sbjct: 154 FSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQE 206
Score = 96.7 bits (239), Expect = 5e-20
Identities = 65/207 (31%), Positives = 105/207 (50%), Gaps = 17/207 (8%)
Query: 339 RSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEV 398
R S+D+ + + +KE+ + R+R E G +R K +ER R + SR
Sbjct: 13 RHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSH-SRSRS 71
Query: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSK 458
E++H R +E+K SRSRSRERK +SRSRSR K+SRSRS+E+ +
Sbjct: 72 RERRH-------------RSRSRERKKSRSRSRERK-KSRSRSRER-KKSRSRSRERKRR 116
Query: 459 HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ 518
++ S+ +S R R+ S+ RT S + +K+ + SR SR+ R + + D
Sbjct: 117 IRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDA 176
Query: 519 SDKHDRRRSQSIE-QESQEKQHKNKDE 544
+ RR ++ + QE +EK+ K +
Sbjct: 177 QEALARRLERAKKLQEQREKEMVEKQK 203
Score = 93.6 bits (231), Expect = 4e-19
Identities = 65/219 (29%), Positives = 102/219 (46%), Gaps = 23/219 (10%)
Query: 328 RRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRE 387
RR S+++ + +S + D+ RE+ N DR KER + R + RSR
Sbjct: 12 RRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRS 71
Query: 388 RSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR 447
R + RSR ++ K+ + R R R +E+K SRSRSRERK R RSRS R
Sbjct: 72 RERRHRSRS----RERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRS-----R 122
Query: 448 SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS 507
SRSR + ++ +S R+RS S+ R +EK ++ S S+ S R + +
Sbjct: 123 SRSRHRHRT---------RSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTA 173
Query: 508 HKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546
D+++ + R + EQ +E K K + +
Sbjct: 174 -----MDAQEALARRLERAKKLQEQREKEMVEKQKQQEI 207
Score = 84.7 bits (208), Expect = 2e-16
Identities = 64/210 (30%), Positives = 93/210 (44%), Gaps = 27/210 (12%)
Query: 264 RRSLSPRRSPRRSRSRSHHREGHGS-----------SSFDRELEREKERQRLEREAKERE 312
RR S +S ++ +S H+ + H S + DR +E++ R ++ R
Sbjct: 12 RRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRS 71
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
+ER R RSRSRER +SRSRSR+RK R R RER+K R R R R +
Sbjct: 72 RER-----------RHRSRSRERKKSRSRSRERK-KSRSRSRERKKSRSRSRERKRRI-R 118
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
R R + R R+R RS R+R ++K + +K R R R R+ + +
Sbjct: 119 SRSRSRSRHRHRTRSRS---RTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMD 175
Query: 433 RKHRSRSRSRNAGKRSRSRSKEKSSKHKNE 462
+ R A K R KE K K +
Sbjct: 176 AQEALARRLERAKKLQEQREKEMVEKQKQQ 205
Score = 82.0 bits (201), Expect = 1e-15
Identities = 61/159 (38%), Positives = 83/159 (52%), Gaps = 8/159 (5%)
Query: 252 DRHVERRRSRSPRRSLSPRRS-PRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKE 310
DRH + R S RS S RS RR RSRS R+ S S +R+ R + R+R + ++
Sbjct: 51 DRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRS 110
Query: 311 REKERR-RSRSIDRGLERRRSRSRERHRSRSRSRDR---KGDRRDRDREREKENERGRRR 366
RE++RR RSRS R R R+RSR R RSRSR R + K R R R R R
Sbjct: 111 RERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGR 170
Query: 367 DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE 405
+ D + R ER + + +EQR + VE++K +E
Sbjct: 171 NTAMDAQEALARRLERAK---KLQEQREKEMVEKQKQQE 206
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/140 (26%), Positives = 64/140 (45%), Gaps = 14/140 (10%)
Query: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEK 466
K RRH + SKK K +H + S + G+ + S+ +HK + ++
Sbjct: 9 KQGRRHESKDKSSKKHKSE--------EHNDKEHSSDKGRERLNSSENGEDRHKRKERKS 60
Query: 467 SNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDR-R 525
S RS S S+ R + + R S ++KSR RSR +++S R K +S +R R
Sbjct: 61 SRGRSHSRSRSR-----ERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKR 115
Query: 526 RSQSIEQESQEKQHKNKDET 545
R +S + +H+ + +
Sbjct: 116 RIRSRSRSRSRHRHRTRSRS 135
Score = 47.4 bits (111), Expect = 3e-05
Identities = 43/134 (32%), Positives = 60/134 (44%), Gaps = 13/134 (9%)
Query: 230 DQQIKTRPRKIKKD---GKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286
+++ ++R R+ KK +E + R ER++SRS R RR RSRSRS HR
Sbjct: 73 ERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERK-RRIRSRSRSRSRHRH-- 129
Query: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRK 346
R R + R R K EK RR SRS+ R R R + R+
Sbjct: 130 ------RTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARR 183
Query: 347 GDRRDR-DREREKE 359
+R + +REKE
Sbjct: 184 LERAKKLQEQREKE 197
>gi|155030242 WD repeat domain 60 [Homo sapiens]
Length = 1066
Score = 99.8 bits (247), Expect = 6e-21
Identities = 82/316 (25%), Positives = 143/316 (45%), Gaps = 37/316 (11%)
Query: 247 GAEEIDRHVERRRSRSPRRSLSPRRSPR------RSRSRSHHREGHGSSSFDR-ELEREK 299
G++E +H E++ + L + PR +RSR E H + R E +R++
Sbjct: 29 GSKEERKHREKKLRKESEMDLPEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDR 88
Query: 300 ERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD-------- 351
+R+R R+AK+REKE+ + + R E+ SR ++R + + R R RK + R
Sbjct: 89 QRER-RRDAKDREKEKLKEKH--REAEKSHSRGKDREKEKDR-RARKEELRQTVAHHNLL 144
Query: 352 ----RDREREKENERG-------RRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEE 400
RDR+ + ER R ++D D ERG+E + R R R+ ++
Sbjct: 145 GQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKY 204
Query: 401 KKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHR-SRSRSRNAGKRSRSRSKEKSSK- 458
+KE+ +RRHR + + K +S +RE++ + S+ +S + + R KEK K
Sbjct: 205 WLYKEE-GERRHRKPREPDRDNKHREKSSTREKREKYSKEKSNSFSDKGEERHKEKRHKE 263
Query: 459 --HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK--RDHSD 514
H ++ + +SN + S +S+ EH S++ S + + R+H
Sbjct: 264 GFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVRNHGK 323
Query: 515 SKDQSDKHDRRRSQSI 530
KD KH S+
Sbjct: 324 DKDSRRKHGHEEGSSV 339
Score = 86.7 bits (213), Expect = 5e-17
Identities = 76/280 (27%), Positives = 129/280 (46%), Gaps = 31/280 (11%)
Query: 287 GSSSFDRELEREKERQRLEREAKEREKERRR-----SRSIDRGLERRRSRSRER-HRSRS 340
G S +R+ +K R+ E + E ++ R R +RS DR E ++ R R R
Sbjct: 28 GGSKEERKHREKKLRKESEMDLPEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRD 87
Query: 341 RSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR----- 395
R R+R+ D +DR++E+ KE + R+ + RG +REKE++R R R +E R
Sbjct: 88 RQRERRRDAKDREKEKLKE----KHREAEKSHSRGKDREKEKDR-RARKEELRQTVAHHN 142
Query: 396 --GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE-RKHRSRSRSRNAGKRSRSRS 452
G+ + ++ +R+ R + +EK R E R+ R R R G +
Sbjct: 143 LLGQETRDRQLLERAERKGRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPL 202
Query: 453 KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRS-----RSKERS 507
K K + E + + + ++ R S + K+ ++ SKEKS S R KE+
Sbjct: 203 KYWLYKEEGERRHRKPREPDRDNKHREKSSTREKREKY--SKEKSNSFSDKGEERHKEKR 260
Query: 508 HKRD-HSDSKDQSDKHDRR----RSQSIEQESQEKQHKNK 542
HK H D + DR+ + + ++ESQ +H+N+
Sbjct: 261 HKEGFHFDDERHQSNVDRKEKSAKDEPRKRESQNGEHRNR 300
Score = 79.0 bits (193), Expect = 1e-14
Identities = 96/367 (26%), Positives = 155/367 (42%), Gaps = 60/367 (16%)
Query: 219 PRIPVPVQKNIDQQIKTRPRKIK----KDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPR 274
P P ++ DQ ++R R + K+ G + DR ERRR R +
Sbjct: 50 PEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREK-EKLKEKH 108
Query: 275 RSRSRSHHREGHGSSSFDRELEREKERQR------LEREAKER---EKERRRSRSI---- 321
R +SH R DR +E+ RQ L +E ++R E+ R+ RS+
Sbjct: 109 REAEKSHSRGKDREKEKDRRARKEELRQTVAHHNLLGQETRDRQLLERAERKGRSVSKVR 168
Query: 322 --------DRGLERRRSRSRERHRSRSRSRDR---------KGDRR-------DRD-RER 356
+RG E R R RER S+D +G+RR DRD + R
Sbjct: 169 SEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHR 228
Query: 357 EKENERGRRRDRDYDK-----ERGNEREKE-RERSRERSKEQRSRGEVEEKKHKEDKDDR 410
EK + R +R +K ++G ER KE R + ++R + V ++K K KD+
Sbjct: 229 EKSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNV-DRKEKSAKDEP 287
Query: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKR 470
R KR+S+ + +R S +R S S++A R+ K+K S+ K+ +E S+
Sbjct: 288 R----KRESQNGEHRNRGASSKRDGTS---SQHAENLVRNHGKDKDSRRKHGHEEGSSVW 340
Query: 471 SRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSI 530
+ + + + +K E ++ + S E + D+ D + D D S
Sbjct: 341 WKLDQRPGGEETVEIEKEETDLENARADAYTASCEDDFE-DYEDDFEVCDGDDDESSN-- 397
Query: 531 EQESQEK 537
E ES+EK
Sbjct: 398 EPESREK 404
Score = 68.9 bits (167), Expect = 1e-11
Identities = 56/221 (25%), Positives = 95/221 (42%), Gaps = 17/221 (7%)
Query: 335 RHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRS 394
+H +S K +R+ R+++ KE+E D KE + RSR+R E +
Sbjct: 20 KHLWAIQSGGSKEERKHREKKLRKESEM----DLPEHKEPRCRDPDQDARSRDRVAEVHT 75
Query: 395 RGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGKRSRSRSK 453
E + D+ R RD K D +KEK + R E+ H R + R + +R+R
Sbjct: 76 AKESPRGERDRDRQRERRRDAK-DREKEKLKEKHREAEKSHSRGKDREKEKDRRARKEEL 134
Query: 454 EKSSKHKNESKEKSNKR---SRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKR 510
++ H N +++ R R+ +GR SV K + E E+ + + R K
Sbjct: 135 RQTVAHHNLLGQETRDRQLLERAERKGR--SVSKVRSEEKDEDSERGDEDRERRYRERKL 192
Query: 511 DHSDSKDQSDKH------DRRRSQSIEQESQEKQHKNKDET 545
+ DSKD K+ RR + + ++ +H+ K T
Sbjct: 193 QYGDSKDNPLKYWLYKEEGERRHRKPREPDRDNKHREKSST 233
Score = 37.0 bits (84), Expect = 0.046
Identities = 37/139 (26%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 410 RRHRDDKRDSKKEKKH-----SRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESK 464
RR +DD + +KH S ERKHR K+ R S+ +HK
Sbjct: 6 RRTKDDTWKADDLRKHLWAIQSGGSKEERKHRE--------KKLRKESEMDLPEHKEPRC 57
Query: 465 EKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDR 524
++ +RS D V + + SP E R R R +ER +RD D + + K
Sbjct: 58 RDPDQDARS-----RDRVAEVHTAKESPRGE--RDRDRQRER--RRDAKDREKEKLKEKH 108
Query: 525 RRSQSIEQESQEKQHKNKD 543
R ++ ++++ K KD
Sbjct: 109 REAEKSHSRGKDRE-KEKD 126
>gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo
sapiens]
Length = 558
Score = 99.4 bits (246), Expect = 8e-21
Identities = 70/264 (26%), Positives = 127/264 (48%), Gaps = 12/264 (4%)
Query: 289 SSFDRELEREKERQRLER--EAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRK 346
SS D E+E + R E+ E E + + RS++ R R S H SR+
Sbjct: 254 SSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGH 313
Query: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406
R D+ ++++ ++ DRDY KER + R +E K R E E+K D
Sbjct: 314 EKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWK----RHEQEDKPRARD 369
Query: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAG-KRSRSRSKEKSSKHKNESKE 465
+ +R R KR+ +EK R + R+R+ ++R G K +S++KE+ K + E E
Sbjct: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYE 429
Query: 466 KSNK-RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK-RDHSDSKDQSDKHD 523
++K R R + S E+++ R+ S +++ + +ERS+K R+ + K+++ +
Sbjct: 430 NNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKP 489
Query: 524 RRRSQSI---EQESQEKQHKNKDE 544
S+ + ++E Q K K++
Sbjct: 490 SNSESSLGAKHRLTEEGQEKGKEQ 513
Score = 95.1 bits (235), Expect = 1e-19
Identities = 75/290 (25%), Positives = 135/290 (46%), Gaps = 24/290 (8%)
Query: 243 DGKEGAEEI--DRHVERRRSR---SPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELER 297
D K A++ + V RR + +P RS SRS S R GH + +
Sbjct: 251 DAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEER-GHSTRHHTKGSRT 309
Query: 298 EKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRERE 357
+ ++ E + ++++ + + DR + R R R S S ++ ++ D+ R R+
Sbjct: 310 SRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARD 369
Query: 358 KENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK-----KHKEDKDDRRH 412
+ R R+ D+E+ ++RE+ER+R + +GE EEK +H + + +R
Sbjct: 370 QRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYE 429
Query: 413 RDDK-RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEK----- 466
+DK RD +EK+ +S ER + S N+ + + +E+S+K +N +K+K
Sbjct: 430 NNDKYRD--REKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQE 487
Query: 467 --SNKRSRSGSQGR--TDSVEKSKKREHSP-SKEKSRKRSRSKERSHKRD 511
SN S G++ R + EK K++E P + K KR+ + RD
Sbjct: 488 KPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARD 537
Score = 72.0 bits (175), Expect = 1e-12
Identities = 62/273 (22%), Positives = 123/273 (45%), Gaps = 22/273 (8%)
Query: 254 HVERRRSRSPRRSLS-PRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
H R ++ R S +R + + +S +E H + DR+ +E++ R REA R+
Sbjct: 298 HSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYT---DRDYRKERDSHR-HREASHRD 353
Query: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
+R D+ R + +R R + R++ R ++ER+++ R +K
Sbjct: 354 SHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQR---EQERDRQQNDQNRPSEKGEK 410
Query: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDS----KKEKKHSRS 428
E ++ ++E + R+ E + EK+ + R++D K S K+K +
Sbjct: 411 EEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQE 470
Query: 429 RSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--NESKEKSNKRSRSGSQGRTDSVEKSK 486
RS + ++ ++ + RN K S S S +KH+ E +EK ++ R ++V K
Sbjct: 471 RSNKMRNMAKDKERNQEKPSNSES-SLGAKHRLTEEGQEKGKEQERP-----PEAVSKFA 524
Query: 487 KREHSPSKEKSRKR--SRSKERSHKRDHSDSKD 517
KR + + +R R +R R + + + + +D
Sbjct: 525 KRNNEETVMSARDRYLARQMARVNAKTYIEKED 557
Score = 62.8 bits (151), Expect = 8e-10
Identities = 48/219 (21%), Positives = 101/219 (46%), Gaps = 10/219 (4%)
Query: 231 QQIKTRPRKIKKDGKEGAEEIDRHVERRRS------RSPRRSLSPRRSPRRSRS-RSHHR 283
QQ ++R ++ ++ +E D H R S + + PR +R RS R R
Sbjct: 321 QQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKR 380
Query: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
E RE ER++++ R +++ EKE +S++ + ++ R+ R + R R +
Sbjct: 381 EKDREKYSQREQERDRQQNDQNRPSEKGEKE-EKSKAKEEHMKVRKERYENNDKYRDREK 439
Query: 344 DRKG-DRRDRDREREKENERGRRRDRDYDKERGNE-REKERERSRERSKEQRSRGEVEEK 401
G +R+++R++ + R +D+ D+ER N+ R +++ R + K S + K
Sbjct: 440 REVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAK 499
Query: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR 440
++ + ++ +R + K ++ + E +R R
Sbjct: 500 HRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDR 538
Score = 53.1 bits (126), Expect = 6e-07
Identities = 58/314 (18%), Positives = 123/314 (39%), Gaps = 33/314 (10%)
Query: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE---- 312
R++ + R +R + +E +S++ ++L+ E + E+ A E
Sbjct: 114 RKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLD 173
Query: 313 --KERRRSRSIDRGLER------------RRSRSR-ERHRSRSRSRDRKGDRRDRDR--- 354
K++ S L + R +RS + +SR S + R
Sbjct: 174 VTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCI 233
Query: 355 -EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413
+ + + E D D+D + + E E R R ++ E + K H+ R
Sbjct: 234 LQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPS 293
Query: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473
+++ S + H++ R H R + ++ +SR +E ++ KE+ + R R
Sbjct: 294 EERGHSTRH--HTKGSRTSRGHEKR---EDQHQQKQSRDQENHYTDRDYRKERDSHRHRE 348
Query: 474 GSQ-----GRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQ 528
S R + +K + R+ ++ KR + +E+ +R+ + Q+D++
Sbjct: 349 ASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKG 408
Query: 529 SIEQESQEKQHKNK 542
E++S+ K+ K
Sbjct: 409 EKEEKSKAKEEHMK 422
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/186 (22%), Positives = 80/186 (43%), Gaps = 9/186 (4%)
Query: 227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286
K +Q+ K R R D +E ++ + + + R S R R+ ++R +
Sbjct: 357 KRHEQEDKPRAR----DQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEE 412
Query: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERR----RSRSRERHRSRSRS 342
S + + ++ KER + ++REK +S +R +R+ SR++++ + RS
Sbjct: 413 KSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERS 472
Query: 343 RDRKGDRRDRDREREK-ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK 401
+ +D++R +EK N + E G E+ KE+ER E + R E
Sbjct: 473 NKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETV 532
Query: 402 KHKEDK 407
D+
Sbjct: 533 MSARDR 538
Score = 50.4 bits (119), Expect = 4e-06
Identities = 57/293 (19%), Positives = 126/293 (43%), Gaps = 37/293 (12%)
Query: 288 SSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347
S S RE +++ ++ + E ++ E D + + + E + +DRK
Sbjct: 42 SESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKP 101
Query: 348 DR--------RDRDREREKENERGRRRDRDYDKERGNERE---------KERERSRERSK 390
R +E+EK E+ +R+R+ +K +++E K +ER+ E +
Sbjct: 102 KYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEER 161
Query: 391 EQRS---RGEVEEKKHKEDKDDRRHRDDKRDSKKE-KKHSRSRSRERKHRSRSRSRNAGK 446
E+R+ ++ K K+ RH ++ ++E K S +R +SR +
Sbjct: 162 EKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEV 221
Query: 447 RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRT---DSVEKSK------------KREHS 491
S++R ++ + + K + N + S ++ D +E+++ + +
Sbjct: 222 SSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFK 281
Query: 492 PSKEKSRKRSRSKERSHK-RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
+ ++ RS S+ER H R H+ S H++R Q +++S+++++ D
Sbjct: 282 HHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTD 334
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 98.6 bits (244), Expect = 1e-20
Identities = 85/350 (24%), Positives = 151/350 (43%), Gaps = 41/350 (11%)
Query: 227 KNIDQQIKTRPRKIKKDGKEGAEEI----DRH-----VERRRSRSPRRSLSPRRSPRRSR 277
K +D+ ++ + R+ +++ K + + DR +E R R ++ R SP R
Sbjct: 11 KTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRRE 70
Query: 278 SRSHHREGHGSSSFDRELER--EKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRER 335
R S + ++ KE+ ++ K +EK R RS S + G R
Sbjct: 71 DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKERE 130
Query: 336 HRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSR 395
H R R R+ + D+ R+ ER+K E R R +ER + ER+R RER ++ +
Sbjct: 131 HERRKRHREEQ-DKARREWERQKRREMAREHSR---RERDRLEQLERKRERERKMREQQK 186
Query: 396 GEVEEKKHKEDKDDRR------------HRDDKRD-SKKEKKHSRSRSRERKHRSRSRSR 442
+ E+K+ + ++RR HR + D S K K SRS R R R
Sbjct: 187 EQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 246
Query: 443 NAGKRSRSRSKEK-----------SSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHS 491
+ K + E+ S+ K S E S+ S SGS+ + E+ ++ E
Sbjct: 247 DGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE--EEEEEEEEEEEEG 304
Query: 492 PSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKN 541
+ E+S + +E + S+S++ S++ S+ E +E++++N
Sbjct: 305 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 354
Score = 92.4 bits (228), Expect = 9e-19
Identities = 75/312 (24%), Positives = 128/312 (41%), Gaps = 30/312 (9%)
Query: 247 GAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLER 306
G E+ ++ + S + + R+ +R R H R E+E+E +R +R
Sbjct: 77 GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKR 136
Query: 307 EAKEREKERRR-SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRR 365
+E++K RR R R + R SR R R R +RK +R + RE++KE +
Sbjct: 137 HREEQDKARREWERQKRREMAREHSR---RERDRLEQLERKRERERKMREQQKEQREQKE 193
Query: 366 RDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDR------RHR----DD 415
R+R R ER KERE RE S R+ E K K R R R D
Sbjct: 194 RER-----RAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 248
Query: 416 KRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGS 475
++ K+EK R + + S S + + S S S+ + E +E+ + +
Sbjct: 249 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 308
Query: 476 QGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKH-----------DR 524
+ + E+ ++ E + S + ++E S + D + +++ H D
Sbjct: 309 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 368
Query: 525 RRSQSIEQESQE 536
S+ E+E E
Sbjct: 369 GESEEAEEEVGE 380
Score = 69.7 bits (169), Expect = 6e-12
Identities = 56/224 (25%), Positives = 107/224 (47%), Gaps = 22/224 (9%)
Query: 312 EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENE-RGRR----- 365
EK+ + +++D L+ ++ R + ++ + R + D RD R+ +E E R R
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIK-RLKNSDDRDSKRDSLEEGELRDHRMEITI 62
Query: 366 RDRDYDKERGNEREKERERSRE-RSKEQRSRGE-VEEKKHKEDKDDRRHRDDKRDSKKEK 423
R+ Y +E E E + S + +Q SR E V +K ++ K+ RRHR S +
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSH---SAEGG 119
Query: 424 KHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
KH+R + +ER+H R R R ++R +E + + E + ++R R R + +E
Sbjct: 120 KHARVKEKEREHERRKRHREEQDKAR---REWERQKRREMAREHSRRERD----RLEQLE 172
Query: 484 KSKKREHS---PSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDR 524
+ ++RE KE+ ++ R + +R +++ + H R
Sbjct: 173 RKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 216
Score = 65.5 bits (158), Expect = 1e-10
Identities = 72/298 (24%), Positives = 119/298 (39%), Gaps = 38/298 (12%)
Query: 226 QKNIDQQIKTRPRKIKKDGKEGA--EEIDRHVERRRSRSPRRSLSPR---RSPRRSRSRS 280
+K+ ++ K R R +G + A +E +R ERR+ + + R R RR +R
Sbjct: 100 RKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMARE 159
Query: 281 H-HREGHGSSSFDRELEREK---ERQRLEREAKEREK---ERRRSRSIDRGLERRRSRSR 333
H RE +R+ ERE+ E+Q+ +RE KERE+ ERR+ R R + R
Sbjct: 160 HSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 219
Query: 334 E--------RHRSRS-----RSRDRKGDRRDRDREREKE-------------NERGRRRD 367
E H SRS R R GD R +E + E +ER
Sbjct: 220 EDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSA 279
Query: 368 RDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR 427
E G+ E+E E E +E + E EE++ +E++++ + ++ ++
Sbjct: 280 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 339
Query: 428 SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKS 485
S + R + SR S + + +E +S + D V S
Sbjct: 340 SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDS 397
Score = 57.0 bits (136), Expect = 4e-08
Identities = 45/197 (22%), Positives = 87/197 (44%), Gaps = 31/197 (15%)
Query: 375 GNEREKERERSRERSKEQRSRGEVEEKKHK----EDKDDRRHRDDKRDSKKE-------- 422
G+E++ + ++ + +++ R + +E+K + ++ DD RD KRDS +E
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDD---RDSKRDSLEEGELRDHRM 58
Query: 423 ----KKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGS-QG 477
+ R + R A K + S+++ H+ + K K +R RS S +G
Sbjct: 59 EITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEG 118
Query: 478 RTDSVEKSKKREHSPSK-----------EKSRKRSRSKERSHKRDHSDSKDQSDKHDRRR 526
+ K K+REH K E R++ R R H R D +Q ++ R
Sbjct: 119 GKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERE 178
Query: 527 SQSIEQESQEKQHKNKD 543
+ EQ+ ++++ K ++
Sbjct: 179 RKMREQQKEQREQKERE 195
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,968,473
Number of Sequences: 37866
Number of extensions: 1145945
Number of successful extensions: 61965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1006
Number of HSP's successfully gapped in prelim test: 1048
Number of HSP's that attempted gapping in prelim test: 9944
Number of HSP's gapped (non-prelim): 16148
length of query: 546
length of database: 18,247,518
effective HSP length: 107
effective length of query: 439
effective length of database: 14,195,856
effective search space: 6231980784
effective search space used: 6231980784
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.