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Search of human proteins with 16554619
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]
(1182 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens] 2410 0.0
gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens] 2362 0.0
gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens] 2336 0.0
gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens] 2256 0.0
gi|41146563 PREDICTED: hypothetical protein LOC653712 [Homo sapi... 184 3e-46
gi|169165594 PREDICTED: hypothetical LOC653712 [Homo sapiens] 183 7e-46
gi|88971034 PREDICTED: hypothetical LOC653712 [Homo sapiens] 183 7e-46
gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens] 64 7e-10
gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens] 64 7e-10
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 59 3e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 59 3e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 58 5e-08
gi|14150171 THO complex 3 [Homo sapiens] 58 5e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 58 6e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 58 6e-08
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 58 6e-08
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 57 1e-07
gi|26665869 WD repeat domain 51B [Homo sapiens] 57 1e-07
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 56 2e-07
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 56 2e-07
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 56 2e-07
gi|55743151 WD repeat domain 19 [Homo sapiens] 56 2e-07
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 56 2e-07
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 56 2e-07
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 55 4e-07
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 55 4e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 55 5e-07
gi|23199987 WD repeat domain 5B [Homo sapiens] 55 5e-07
gi|46358428 selective LIM binding factor homolog [Homo sapiens] 54 9e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 53 2e-06
>gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]
Length = 1182
Score = 2410 bits (6246), Expect = 0.0
Identities = 1182/1182 (100%), Positives = 1182/1182 (100%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS
Sbjct: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
Query: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW
Sbjct: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
Query: 181 SICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGG 240
SICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGG
Sbjct: 181 SICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGG 240
Query: 241 SDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLY 300
SDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLY
Sbjct: 241 SDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLY 300
Query: 301 KDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDL 360
KDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDL
Sbjct: 301 KDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDL 360
Query: 361 SDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVI 420
SDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVI
Sbjct: 361 SDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVI 420
Query: 421 GGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCL 480
GGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCL
Sbjct: 421 GGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCL 480
Query: 481 VYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNG 540
VYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNG
Sbjct: 481 VYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNG 540
Query: 541 SKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDF 600
SKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDF
Sbjct: 541 SKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDF 600
Query: 601 ETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHE 660
ETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHE
Sbjct: 601 ETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHE 660
Query: 661 NLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVK 720
NLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVK
Sbjct: 661 NLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVK 720
Query: 721 AIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQ 780
AIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQ
Sbjct: 721 AIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQ 780
Query: 781 LHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLE 840
LHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLE
Sbjct: 781 LHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLE 840
Query: 841 QLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIH 900
QLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIH
Sbjct: 841 QLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIH 900
Query: 901 RHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAY 960
RHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAY
Sbjct: 901 RHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAY 960
Query: 961 DKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQ 1020
DKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQ
Sbjct: 961 DKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQ 1020
Query: 1021 PFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVE 1080
PFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVE
Sbjct: 1021 PFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVE 1080
Query: 1081 TKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLL 1140
TKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLL
Sbjct: 1081 TKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLL 1140
Query: 1141 PDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1182
PDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1141 PDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1182
>gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]
Length = 1241
Score = 2362 bits (6121), Expect = 0.0
Identities = 1175/1241 (94%), Positives = 1177/1241 (94%), Gaps = 59/1241 (4%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS
Sbjct: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
Query: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI- 179
PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI
Sbjct: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
Query: 180 ---------WSICW---------------------------------------------- 184
W W
Sbjct: 181 SICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDD 240
Query: 185 ---NPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 241
+ + EERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS
Sbjct: 241 SPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGS 300
Query: 242 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 301
DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK
Sbjct: 301 DKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYK 360
Query: 302 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 361
DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS
Sbjct: 361 DRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLS 420
Query: 362 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 421
DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG
Sbjct: 421 DMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIG 480
Query: 422 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 481
GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV
Sbjct: 481 GPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLV 540
Query: 482 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 541
YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS
Sbjct: 541 YDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGS 600
Query: 542 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 601
KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE
Sbjct: 601 KIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFE 660
Query: 602 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 661
TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN
Sbjct: 661 TAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHEN 720
Query: 662 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 721
LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA
Sbjct: 721 LALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKA 780
Query: 722 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 781
IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL
Sbjct: 781 IEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQL 840
Query: 782 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 841
HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ
Sbjct: 841 HVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQ 900
Query: 842 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR 901
LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR
Sbjct: 901 LTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHR 960
Query: 902 HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD 961
HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD
Sbjct: 961 HTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYD 1020
Query: 962 KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP 1021
KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP
Sbjct: 1021 KLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQP 1080
Query: 1022 FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET 1081
FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET
Sbjct: 1081 FIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVET 1140
Query: 1082 KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP 1141
KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP
Sbjct: 1141 KDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLP 1200
Query: 1142 DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1182
DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1201 DASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1241
>gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens]
Length = 1292
Score = 2336 bits (6055), Expect = 0.0
Identities = 1174/1292 (90%), Positives = 1177/1292 (91%), Gaps = 110/1292 (8%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYT----------------------------- 91
YAKDGKRFASGSADKSVIIWTSKLEGILKYT
Sbjct: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTSWSVMSSLHLHLPFLGLHKTVRVTATDKA 120
Query: 92 ----------------------HNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKH 129
HNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKH
Sbjct: 121 PKGQGGRIDCLRPSVQNQPGQKHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKH 180
Query: 130 KSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI---------- 179
KSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPI
Sbjct: 181 KSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSR 240
Query: 180 WSICW-------------------------------------------------NPSREE 190
W W + + EE
Sbjct: 241 WESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEE 300
Query: 191 RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK 250
RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK
Sbjct: 301 RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK 360
Query: 251 DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSM 310
DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSM
Sbjct: 361 DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSM 420
Query: 311 TDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEK 370
TDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEK
Sbjct: 421 TDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEK 480
Query: 371 IIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLL 430
IIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLL
Sbjct: 481 IIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLL 540
Query: 431 VGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELL 490
VGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELL
Sbjct: 541 VGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELL 600
Query: 491 FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFS 550
FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFS
Sbjct: 601 FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFS 660
Query: 551 ISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRV 610
ISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRV
Sbjct: 661 ISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRV 720
Query: 611 QDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDL 670
QDLRYLELISSIEERKK+GETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDL
Sbjct: 721 QDLRYLELISSIEERKKQGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDL 780
Query: 671 CMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGW 730
CMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGW
Sbjct: 781 CMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGW 840
Query: 731 VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDE 790
VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDE
Sbjct: 841 VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDE 900
Query: 791 AFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAES 850
AFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAES
Sbjct: 901 AFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAES 960
Query: 851 RFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVH 910
RFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVH
Sbjct: 961 RFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVH 1020
Query: 911 RPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPA 970
RPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPA
Sbjct: 1021 RPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPA 1080
Query: 971 RFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYD 1030
RFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYD
Sbjct: 1081 RFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYD 1140
Query: 1031 VLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDP 1090
VLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDP
Sbjct: 1141 VLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDP 1200
Query: 1091 FTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPS 1150
FTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPS
Sbjct: 1201 FTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPS 1260
Query: 1151 CFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1182
CFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1261 CFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1292
>gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens]
Length = 1131
Score = 2256 bits (5847), Expect = 0.0
Identities = 1122/1183 (94%), Positives = 1125/1183 (95%), Gaps = 53/1183 (4%)
Query: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVA 60
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKG
Sbjct: 1 MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKG--------- 51
Query: 61 YAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWS 120
H D + CV+Y + GLWS
Sbjct: 52 -------------------------------HKDTVYCVAY------------AKDGLWS 68
Query: 121 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW
Sbjct: 69 PEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 128
Query: 181 SICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGG 240
SICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGG
Sbjct: 129 SICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGG 188
Query: 241 SDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLY 300
SDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLY
Sbjct: 189 SDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLY 248
Query: 301 KDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDL 360
KDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDL
Sbjct: 249 KDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDL 308
Query: 361 SDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVI 420
SDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVI
Sbjct: 309 SDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVI 368
Query: 421 GGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCL 480
GGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCL
Sbjct: 369 GGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCL 428
Query: 481 VYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNG 540
VYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNG
Sbjct: 429 VYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNG 488
Query: 541 SKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDF 600
SKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDF
Sbjct: 489 SKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDF 548
Query: 601 ETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHE 660
ETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHE
Sbjct: 549 ETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHE 608
Query: 661 NLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVK 720
NLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVK
Sbjct: 609 NLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVK 668
Query: 721 AIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQ 780
AIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQ
Sbjct: 669 AIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQ 728
Query: 781 LHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLE 840
LHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLE
Sbjct: 729 LHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLE 788
Query: 841 QLTNNAVAESRFNDAAYYYWMLSMQCLDIAQ-DPAQKDTMLGKFYHFQRLAELYHGYHAI 899
QLTNNAVAESRFNDAAYYYWMLSMQCLDIAQ DPAQKDTMLGKFYHFQRLAELYHGYHAI
Sbjct: 789 QLTNNAVAESRFNDAAYYYWMLSMQCLDIAQADPAQKDTMLGKFYHFQRLAELYHGYHAI 848
Query: 900 HRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHA 959
HRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHA
Sbjct: 849 HRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHA 908
Query: 960 YDKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCR 1019
YDKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCR
Sbjct: 909 YDKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCR 968
Query: 1020 QPFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLV 1079
QPFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLV
Sbjct: 969 QPFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLV 1028
Query: 1080 ETKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSL 1139
ETKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSL
Sbjct: 1029 ETKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSL 1088
Query: 1140 LPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1182
LPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
Sbjct: 1089 LPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP 1131
>gi|41146563 PREDICTED: hypothetical protein LOC653712 [Homo
sapiens]
Length = 121
Score = 184 bits (468), Expect = 3e-46
Identities = 92/96 (95%), Positives = 92/96 (95%), Gaps = 1/96 (1%)
Query: 463 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAS 522
MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGG LNIKAS
Sbjct: 1 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGNLNIKAS 60
Query: 523 TFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQ 558
FPVH QKLQGFVVGYNGSKIFCLHVF ISAVEVPQ
Sbjct: 61 IFPVHWQKLQGFVVGYNGSKIFCLHVF-ISAVEVPQ 95
>gi|169165594 PREDICTED: hypothetical LOC653712 [Homo sapiens]
Length = 121
Score = 183 bits (465), Expect = 7e-46
Identities = 91/96 (94%), Positives = 92/96 (95%), Gaps = 1/96 (1%)
Query: 463 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAS 522
MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGG LNIKAS
Sbjct: 1 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGNLNIKAS 60
Query: 523 TFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQ 558
FPVH QKLQGFVVGYNGSKIFCLHVF ISA+EVPQ
Sbjct: 61 IFPVHWQKLQGFVVGYNGSKIFCLHVF-ISALEVPQ 95
>gi|88971034 PREDICTED: hypothetical LOC653712 [Homo sapiens]
Length = 121
Score = 183 bits (465), Expect = 7e-46
Identities = 91/96 (94%), Positives = 92/96 (95%), Gaps = 1/96 (1%)
Query: 463 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKAS 522
MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGG LNIKAS
Sbjct: 1 MSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGNLNIKAS 60
Query: 523 TFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQ 558
FPVH QKLQGFVVGYNGSKIFCLHVF ISA+EVPQ
Sbjct: 61 IFPVHWQKLQGFVVGYNGSKIFCLHVF-ISALEVPQ 95
>gi|56243599 WD repeat domain 35 isoform 2 [Homo sapiens]
Length = 1170
Score = 64.3 bits (155), Expect = 7e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 429 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 487
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 506 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 565
Query: 488 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 536
ELL + + + W D+ + + + P + G++
Sbjct: 566 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 625
Query: 537 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 586
+ +I + + I E P + + R L I +G+ D
Sbjct: 626 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 685
Query: 587 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 643
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 686 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 739
Query: 644 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 699
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 740 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 799
Query: 700 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 759
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 800 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 858
Query: 760 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 818
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 859 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 918
Query: 819 FEEAQKAFHKAGRQREAVQVLEQLTN 844
+A + + KA +A +++ ++ +
Sbjct: 919 TLDAIELYRKANYFFDAAKLMFKIAD 944
Score = 35.8 bits (81), Expect = 0.25
Identities = 27/143 (18%), Positives = 62/143 (43%), Gaps = 20/143 (13%)
Query: 41 SDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT----SKLEGILKYTHNDAI 96
S+ ++ Q L+GH +V V + + ++ + + +I+W S +E ++ + +
Sbjct: 59 SNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
Query: 97 QCVSYNPITHQLASC---------SSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYL 147
+ +S+N ++ S +W + K + ++ +W+ D + L
Sbjct: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGI-------QLSHVTWSADSKVL 171
Query: 148 ALGMFNGIISIRNKNGEEKVKIE 170
GM NG I I + G +K++
Sbjct: 172 LFGMANGEIHIYDNQGNFMIKMK 194
>gi|55743161 WD repeat domain 35 isoform 1 [Homo sapiens]
Length = 1181
Score = 64.3 bits (155), Expect = 7e-10
Identities = 90/446 (20%), Positives = 181/446 (40%), Gaps = 37/446 (8%)
Query: 429 LLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTK- 487
L+VG ++G I + + N+ I L ++ + +LA++D + +D+D +
Sbjct: 517 LIVGRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARV 576
Query: 488 ----------ELL-FQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVV 536
ELL + + + W D+ + + + P + G++
Sbjct: 577 TDSTGQQVVGELLKLERRDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYIC 636
Query: 537 GYNGSKIFCLHVFSI-SAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTD--------- 586
+ +I + + I E P + + R L I +G+ D
Sbjct: 637 NFEDLEIKSVLLDEILKDPEHPNKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHP 696
Query: 587 --WRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGE-TNNDLFLADVFSY 643
WR LA AL+ LD TA++AF+R +D + ++ + K+ G+ + + A+V Y
Sbjct: 697 RLWRLLAEAALQKLDLYTAEQAFVRCKDYQGIKFV------KRLGKLLSESMKQAEVVGY 750
Query: 644 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFL--GSGDPKETKMLITKQA--DWA 699
G+F EA + Y +LA+ + L + L GSGD ++ + A D+
Sbjct: 751 FGRFEEAERTYLEMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGDYF 810
Query: 700 RNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKL 759
+ ++ AV+ Y+ + E + L ++A L + + L A ++
Sbjct: 811 ADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLAISLPE-NHKLLPEIAQMFVRV 869
Query: 760 DSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK-DDIYMPYAQWLAENDR 818
A +LK K+ V V +W++A L + H + + YA L E ++
Sbjct: 870 GMCEQAVTAFLKCSQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNK 929
Query: 819 FEEAQKAFHKAGRQREAVQVLEQLTN 844
+A + + KA +A +++ ++ +
Sbjct: 930 TLDAIELYRKANYFFDAAKLMFKIAD 955
Score = 35.8 bits (81), Expect = 0.25
Identities = 27/143 (18%), Positives = 62/143 (43%), Gaps = 20/143 (13%)
Query: 41 SDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT----SKLEGILKYTHNDAI 96
S+ ++ Q L+GH +V V + + ++ + + +I+W S +E ++ + +
Sbjct: 59 SNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYKGSWIEEMINNRNKSVV 118
Query: 97 QCVSYNPITHQLASC---------SSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYL 147
+ +S+N ++ S +W + K + ++ +W+ D + L
Sbjct: 119 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGI-------QLSHVTWSADSKVL 171
Query: 148 ALGMFNGIISIRNKNGEEKVKIE 170
GM NG I I + G +K++
Sbjct: 172 LFGMANGEIHIYDNQGNFMIKMK 194
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 58.9 bits (141), Expect = 3e-08
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 42 DGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG-ILKYT-HNDAIQCV 99
D +L + KGH+D V CV ++ + K+ ASGS D +++W K + ++T H DA+ CV
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 100 SYNPITHQLASCS-SSDFGLWSPEQKSVS 127
+++P H LAS S +W P K S
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAG-SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N ++F P G LI A+ S L + D +G LL L GH+ VA+++ G+ FASG +
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 74 DKSVIIWTSKLE 85
D+ V++W S +
Sbjct: 292 DEQVMVWKSNFD 303
Score = 47.8 bits (112), Expect = 6e-05
Identities = 60/283 (21%), Positives = 113/283 (39%), Gaps = 21/283 (7%)
Query: 29 LAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLE 85
LA+GS L+V+ + GHKD V CV ++ G ASGS DK+V IW ++
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
Query: 86 G--ILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQK----SVSKHKSSSKIICC 138
G + H ++ V + + S +W+ ++ S+S+H + + C
Sbjct: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH--INWVRCA 151
Query: 139 SWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVA 198
++ DG+ + + + + +K+ E V G + + ++PS +A A
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF--VTYVDFHPS----GTCIAAA 205
Query: 199 DWGQKVSFYQLSGKQIGKDRALNFDPC-CISYFTKGEYILLGGSDKQVSLF-TKDGVRLG 256
V + + ++ + L+ +S+ G Y++ SD + + +G L
Sbjct: 206 GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
Query: 257 TVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTV-HG 298
T+ T Y G D + ++ F V HG
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHG 308
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 58.9 bits (141), Expect = 3e-08
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 42 DGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG-ILKYT-HNDAIQCV 99
D +L + KGH+D V CV ++ + K+ ASGS D +++W K + ++T H DA+ CV
Sbjct: 8 DPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCV 67
Query: 100 SYNPITHQLASCS-SSDFGLWSPEQKSVS 127
+++P H LAS S +W P K S
Sbjct: 68 NFSPSGHLLASGSRDKTVRIWVPNVKGES 96
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAG-SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N ++F P G LI A+ S L + D +G LL L GH+ VA+++ G+ FASG +
Sbjct: 232 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 74 DKSVIIWTSKLE 85
D+ V++W S +
Sbjct: 292 DEQVMVWKSNFD 303
Score = 47.8 bits (112), Expect = 6e-05
Identities = 60/283 (21%), Positives = 113/283 (39%), Gaps = 21/283 (7%)
Query: 29 LAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLE 85
LA+GS L+V+ + GHKD V CV ++ G ASGS DK+V IW ++
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
Query: 86 G--ILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQK----SVSKHKSSSKIICC 138
G + H ++ V + + S +W+ ++ S+S+H + + C
Sbjct: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH--INWVRCA 151
Query: 139 SWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVA 198
++ DG+ + + + + +K+ E V G + + ++PS +A A
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF--VTYVDFHPS----GTCIAAA 205
Query: 199 DWGQKVSFYQLSGKQIGKDRALNFDPC-CISYFTKGEYILLGGSDKQVSLF-TKDGVRLG 256
V + + ++ + L+ +S+ G Y++ SD + + +G L
Sbjct: 206 GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 265
Query: 257 TVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTV-HG 298
T+ T Y G D + ++ F V HG
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHG 308
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 58.2 bits (139), Expect = 5e-08
Identities = 72/323 (22%), Positives = 136/323 (42%), Gaps = 49/323 (15%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKD-GKRFASGS 72
+ ++A G+ I + R ++DT+ G L L+GH++ VY +A+ G + A+GS
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 73 ADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPITHQLASCS-SSDFGLWSPE--QKSV 126
DK+ +W+ + G +T H I C+S+NP + +A+ S + LW + ++
Sbjct: 155 FDKTCKLWSVE-TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKI------ERPGGSLSPIW 180
+ S++II S+ G + G F+ + + + + KV I E S +
Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC 273
Query: 181 SICWNPSREER-------------------NDIL-------------AVADWGQKVSFYQ 208
S+ S ++ ++IL A AD ++ F
Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARI-FSA 332
Query: 209 LSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLF-TKDGVRLGTVGEQNSWVWT 267
+ K I K + IS+ +G ++L G SDK ++ + G L + +++
Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS 392
Query: 268 CQAKPDSNYVVVGCQDGTISFYQ 290
C N V+ G +D T ++
Sbjct: 393 CAFNYKGNIVITGSKDNTCRIWR 415
Score = 38.5 bits (88), Expect = 0.038
Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 18/151 (11%)
Query: 13 HC--INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFA 69
HC I+ +F D + ++ + + ++D ++G + L GH D + + GK A
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319
Query: 70 SGSADKSVIIWT-------SKLEGILKYTHNDAIQCVSYNPI-THQLASCSSSDFGLWSP 121
+ SAD + I++ +KLEG H I +S+NP H L S +W
Sbjct: 320 TASADGTARIFSAATRKCIAKLEG-----HEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 122 EQKSVSK--HKSSSKIICCSWTNDGQYLALG 150
+ + + +I C++ G + G
Sbjct: 375 QTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
Score = 36.6 bits (83), Expect = 0.15
Identities = 44/180 (24%), Positives = 80/180 (44%), Gaps = 27/180 (15%)
Query: 45 LLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIW-------TSKLEGILKYTHNDAIQ 97
L + LK H + VA K G F +GS D++ +W + LEG H + +
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEG-----HRNVVY 138
Query: 98 CVSY-NPITHQLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLALGMFN 153
+++ NP ++A+ S LWS E + +++I+C S+ +A G +
Sbjct: 139 AIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMD 198
Query: 154 GIISIRN-KNGEEKVKIERPGGSLSPIWSICWNPSRE-------ERNDILAVADWGQKVS 205
+ + +NGEE + G + I S+ +N S + + ++ AD G+KV+
Sbjct: 199 TTAKLWDIQNGEEVYTLR---GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255
>gi|14150171 THO complex 3 [Homo sapiens]
Length = 351
Score = 58.2 bits (139), Expect = 5e-08
Identities = 51/215 (23%), Positives = 97/215 (45%), Gaps = 29/215 (13%)
Query: 52 HKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT----HNDAIQCVSYNPITHQ 107
H V+ VA++ DG+R ASGS DK+ ++ + + ++K H D++ + ++P
Sbjct: 54 HSAKVHSVAWSCDGRRLASGSFDKTASVFLLEKDRLVKENNYRGHGDSVDQLCWHPSNPD 113
Query: 108 LASCSSSD--FGLWSPE-QKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI-----R 159
L +S D +W K ++ + + I W+ DGQ +A+G + +++
Sbjct: 114 LFVTASGDKTIRIWDVRTTKCIATVNTKGENINICWSPDGQTIAVGNKDDVVTFIDAKTH 173
Query: 160 NKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRA 219
EE+ K E + I WN N++ + + ++ LS ++ ++
Sbjct: 174 RSKAEEQFKFE--------VNEISWN----NDNNMFFLTNGNGCINI--LSYPELKPVQS 219
Query: 220 LNFDP---CCISYFTKGEYILLGGSDKQVSLFTKD 251
+N P CI + G+Y G +D VSL+ D
Sbjct: 220 INAHPSNCICIKFDPMGKYFATGSADALVSLWDVD 254
Score = 39.7 bits (91), Expect = 0.017
Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 6 TWRDKAEHC----INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVA 60
T R KAE +N+I++ D L G+ + + + +Q + H C+
Sbjct: 172 THRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHPSNCICIK 231
Query: 61 YAKDGKRFASGSADKSVIIW-TSKLEGILKYTHND-AIQCVSYNPITHQLASCSSSDF 116
+ GK FA+GSAD V +W +L + ++ D ++ +S++ LAS S F
Sbjct: 232 FDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDGKMLASASEDHF 289
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 57.8 bits (138), Expect = 6e-08
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 3/91 (3%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+D+A+ D L+ A+ + L ++D S G L+ LKGH + V+C + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 74 DKSVIIWTSKLEGILKY--THNDAIQCVSYN 102
D+SV IW K LK H+D + V +N
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Score = 50.4 bits (119), Expect = 1e-05
Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 10/152 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
++ + F P+G L ++ +L+ ++ DG + + GHK + VA++ D S S
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 74 DKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQ----KSV 126
DK++ IW LK H++ + C ++NP ++ + S S +W + K++
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
H S + + DG + ++G+ I
Sbjct: 168 PAH--SDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCV---AYAKDGKRFAS 70
++ + F P+G ++ A + L ++D S G L+ GHK+ YC+ GK S
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 71 GSADKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS 112
GS D V IW + + I++ H D + + +P + +AS +
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 39.7 bits (91), Expect = 0.017
Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 9/141 (6%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKY---THN 93
++D G L+ L H D V V + +DG S S D IW + LK N
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 94 DAIQCVSYNPI-THQLASCSSSDFGLWSPEQ----KSVSKHKSSSKIICCSWT-NDGQYL 147
+ V ++P + LA+ + LW + K+ + HK+ I +++ G+++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 148 ALGMFNGIISIRNKNGEEKVK 168
G + ++ I N +E V+
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQ 295
Score = 38.1 bits (87), Expect = 0.050
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 11/118 (9%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPIT 105
L GH V V ++ +G+ AS SADK + IW +G + T H I V+++ +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 106 HQLASCS-SSDFGLWSPEQ----KSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ L S S +W K++ H S+ + CC++ + G F+ + I
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSGSFDESVRI 155
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 57.8 bits (138), Expect = 6e-08
Identities = 32/91 (35%), Positives = 48/91 (52%), Gaps = 3/91 (3%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+D+A+ D L+ A+ + L ++D S G L+ LKGH + V+C + SGS
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 74 DKSVIIWTSKLEGILKY--THNDAIQCVSYN 102
D+SV IW K LK H+D + V +N
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Score = 50.4 bits (119), Expect = 1e-05
Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 10/152 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
++ + F P+G L ++ +L+ ++ DG + + GHK + VA++ D S S
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107
Query: 74 DKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQ----KSV 126
DK++ IW LK H++ + C ++NP ++ + S S +W + K++
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
H S + + DG + ++G+ I
Sbjct: 168 PAH--SDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCV---AYAKDGKRFAS 70
++ + F P+G ++ A + L ++D S G L+ GHK+ YC+ GK S
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
Query: 71 GSADKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS 112
GS D V IW + + I++ H D + + +P + +AS +
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320
Score = 39.7 bits (91), Expect = 0.017
Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 9/141 (6%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKY---THN 93
++D G L+ L H D V V + +DG S S D IW + LK N
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 94 DAIQCVSYNPI-THQLASCSSSDFGLWSPEQ----KSVSKHKSSSKIICCSWT-NDGQYL 147
+ V ++P + LA+ + LW + K+ + HK+ I +++ G+++
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
Query: 148 ALGMFNGIISIRNKNGEEKVK 168
G + ++ I N +E V+
Sbjct: 275 VSGSEDNLVYIWNLQTKEIVQ 295
Score = 38.1 bits (87), Expect = 0.050
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 11/118 (9%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPIT 105
L GH V V ++ +G+ AS SADK + IW +G + T H I V+++ +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 106 HQLASCS-SSDFGLWSPEQ----KSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ L S S +W K++ H S+ + CC++ + G F+ + I
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSGSFDESVRI 155
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 57.8 bits (138), Expect = 6e-08
Identities = 59/235 (25%), Positives = 93/235 (39%), Gaps = 17/235 (7%)
Query: 22 PDGTQLILAAGS--RLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVII 79
P T IL G+ ++V+D S +L LKGH V V + S S D ++ I
Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290
Query: 80 WTSKLEGILKY--THNDAIQCVSYNPITHQLASCSSSDFGLWSPEQ-----KSVSKHKSS 132
W+ ++ H A+ +S + L S S + +S Q V+ S
Sbjct: 291 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 350
Query: 133 SKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERN 192
+ C + DG G + I I + +E+ + G PI SI ++ E
Sbjct: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDL--KERTNVANFPGHSGPITSIAFS----ENG 404
Query: 193 DILAVADWGQKVSFYQLSGKQIGKDRAL--NFDPCCISYFTKGEYILLGGSDKQV 245
LA A V + L + K L NF+ + + G Y+ LGG+D Q+
Sbjct: 405 YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 459
Score = 35.4 bits (80), Expect = 0.32
Identities = 19/64 (29%), Positives = 34/64 (53%), Gaps = 5/64 (7%)
Query: 20 FKPDGTQLILAAG---SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKS 76
F PDG LI G S++ ++D + T + GH + +A++++G A+ + D S
Sbjct: 358 FHPDG--LIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSS 415
Query: 77 VIIW 80
V +W
Sbjct: 416 VKLW 419
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAG-SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N ++F P G LI A+ S L + D +G LL L GH+ VA+++ G+ FASG +
Sbjct: 194 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 74 DKSVIIWTSKLE 85
D+ V++W S +
Sbjct: 254 DEQVMVWKSNFD 265
Score = 46.6 bits (109), Expect = 1e-04
Identities = 57/276 (20%), Positives = 109/276 (39%), Gaps = 18/276 (6%)
Query: 33 SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG--ILKY 90
S L+V+ + GHKD V CV ++ G ASGS DK+V IW ++G +
Sbjct: 3 SCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR 62
Query: 91 THNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQK----SVSKHKSSSKIICCSWTNDGQ 145
H ++ V + + S +W+ ++ S+S+H + + C ++ DG+
Sbjct: 63 AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQH--INWVRCAKFSPDGR 120
Query: 146 YLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVADWGQKVS 205
+ + + + +K+ E V G + + ++PS +A A V
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGF--VTYVDFHPS----GTCIAAAGMDNTVK 174
Query: 206 FYQLSGKQIGKDRALNFDPC-CISYFTKGEYILLGGSDKQVSLF-TKDGVRLGTVGEQNS 263
+ + ++ + L+ +S+ G Y++ SD + + +G L T+
Sbjct: 175 VWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQG 234
Query: 264 WVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTV-HG 298
T Y G D + ++ F V HG
Sbjct: 235 PATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHG 270
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 56.6 bits (135), Expect = 1e-07
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N I+F P G LI A+ L + D +G L+ L+GH V+ V+++K G+ FASG A
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
Query: 74 DKSVIIWTSKLE 85
D V++W + +
Sbjct: 291 DTQVLLWRTNFD 302
Score = 49.3 bits (116), Expect = 2e-05
Identities = 60/268 (22%), Positives = 113/268 (42%), Gaps = 29/268 (10%)
Query: 40 TSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEG-ILKYT-HNDAIQ 97
T D L + KGHK + + + +GK+ A+ S D +++W K +Y H D +
Sbjct: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64
Query: 98 CVSYNPITHQLASCS-SSDFGLWSPEQK-SVSKHKS-SSKIICCSWTNDGQYLALGMFNG 154
V ++P + LAS S LW P+++ S+ K+ ++ + ++ DGQ+LA +
Sbjct: 65 SVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDK 124
Query: 155 IISIRNKNGEEKV-KIERPGGSLSPIWSICWNPSREERNDILAVADWGQKVSFYQLSGKQ 213
I + + + + + R W C S + R ++ + + + + KQ
Sbjct: 125 SIKVWSMYRQRFLYSLYR-----HTHWVRCAKFSPDGR--LIVSCSEDKTIKIWDTTNKQ 177
Query: 214 --------IGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWV 265
+G ++F+P G I GSD+ V ++ +L + +S
Sbjct: 178 CVNNFSDSVGFANFVDFNP-------SGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGG 230
Query: 266 WTC-QAKPDSNYVVVGCQDGTISFYQLI 292
C P NY++ DGT+ L+
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDLL 258
Score = 45.1 bits (105), Expect = 4e-04
Identities = 59/291 (20%), Positives = 113/291 (38%), Gaps = 14/291 (4%)
Query: 15 INDIAFKPDGTQLILAAGSR-LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I + P+G QL A+ L++++ GHKD V V ++ G AS S
Sbjct: 21 ITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASR 80
Query: 74 DKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPEQKS--VSK 128
D++V +W G H ++ V ++ LA+ S +WS ++ S
Sbjct: 81 DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL 140
Query: 129 HKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSR 188
++ + + C ++ DG+ + + I I + ++ V S+ + +NPS
Sbjct: 141 YRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV--NNFSDSVGFANFVDFNPS- 197
Query: 189 EERNDILAVADWGQKVSFYQLS-GKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSL 247
+A A Q V + + K + + + CIS+ G Y++ SD + +
Sbjct: 198 ---GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
Query: 248 F-TKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVH 297
+G + T+ V+T G D + ++ F +H
Sbjct: 255 LDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELH 305
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 56.2 bits (134), Expect = 2e-07
Identities = 55/214 (25%), Positives = 97/214 (45%), Gaps = 23/214 (10%)
Query: 13 HCINDIAFKPDGTQLILAAG--SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFAS 70
H ++D+ DG Q L+ L ++D + GT + GH V VA++ D ++ S
Sbjct: 64 HFVSDVVISSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
Query: 71 GSADKSVIIWTSKLEGILKYT-----HNDAIQCVSYNPITHQ--LASCSSSDF-GLWS-P 121
GS DK++ +W + G+ KYT H++ + CV ++P + + SC +W+
Sbjct: 123 GSRDKTIKLWNTL--GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180
Query: 122 EQKSVSKHKSSSKII-CCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIW 180
K + H + + + + DG A G +G + + N E K GG + I
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN-EGKHLYTLDGGDI--IN 237
Query: 181 SICWNPSREERNDILAVADWGQKVSFYQLSGKQI 214
++C++P+R A G + + L GK I
Sbjct: 238 ALCFSPNR-----YWLCAATGPSIKIWDLEGKII 266
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 56.2 bits (134), Expect = 2e-07
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 18/124 (14%)
Query: 15 INDIAFKPDGTQLILAAGSR---LLVYDTSD-GTLLQPLKGHKDTVYCVAYAKDGKRFAS 70
+ D+ F PDG+ LIL + SR L V+D D G +++ L+GH++ VY A++ D S
Sbjct: 173 VRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 231
Query: 71 GSADKSVIIWT-------SKLEGILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPE 122
A K+V +W KLEG H+D + C ++P LA+ S + +W P
Sbjct: 232 VGASKAVFLWNMDKYTMIRKLEG----HHHDVVAC-DFSPDGALLATASYDTRVYIWDPH 286
Query: 123 QKSV 126
+
Sbjct: 287 NGDI 290
Score = 49.3 bits (116), Expect = 2e-05
Identities = 60/256 (23%), Positives = 112/256 (43%), Gaps = 20/256 (7%)
Query: 9 DKAEHCINDI--AFKPDGTQLILAAG---SRLLVYDTSDGTLLQPLKGHKDTVYCVAYAK 63
+K C+N F+ QL+LA G R+ ++D G LL L H + V + +A
Sbjct: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
Query: 64 DGKR-FASGSADKSVIIWTSKLEGILKYT---HNDAIQCVSYNPITHQLASCSSSD-FGL 118
DG S S DK++ +W K +G + H + + +++P + L S +S L
Sbjct: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240
Query: 119 WSPEQKSVSKHKSS--SKIICCSWTNDGQYLALGMFNGIISIRN-KNGEEKVKIERPGGS 175
W+ ++ ++ + ++ C ++ DG LA ++ + I + NG+ ++
Sbjct: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300
Query: 176 LSPIW----SICWNPSREERNDILAVADWG--QKVSFYQLSGKQIGKDRALNFDPCCISY 229
+PI+ + W S +D L VA + V F+++ + L+ CC ++
Sbjct: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCC-AF 359
Query: 230 FTKGEYILLGGSDKQV 245
T G + G D V
Sbjct: 360 STDGSVLAAGTHDGSV 375
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 56.2 bits (134), Expect = 2e-07
Identities = 40/124 (32%), Positives = 63/124 (50%), Gaps = 18/124 (14%)
Query: 15 INDIAFKPDGTQLILAAGSR---LLVYDTSD-GTLLQPLKGHKDTVYCVAYAKDGKRFAS 70
+ D+ F PDG+ LIL + SR L V+D D G +++ L+GH++ VY A++ D S
Sbjct: 27 VRDLTFAPDGS-LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 85
Query: 71 GSADKSVIIWT-------SKLEGILKYTHNDAIQCVSYNPITHQLASCS-SSDFGLWSPE 122
A K+V +W KLEG H+D + C ++P LA+ S + +W P
Sbjct: 86 VGASKAVFLWNMDKYTMIRKLEG----HHHDVVAC-DFSPDGALLATASYDTRVYIWDPH 140
Query: 123 QKSV 126
+
Sbjct: 141 NGDI 144
>gi|55743151 WD repeat domain 19 [Homo sapiens]
Length = 1342
Score = 56.2 bits (134), Expect = 2e-07
Identities = 132/670 (19%), Positives = 256/670 (38%), Gaps = 85/670 (12%)
Query: 250 KDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDS 309
KD + + E+N + T D + + Q G++ + + R AY S
Sbjct: 307 KDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTS 366
Query: 310 MTDVIVQHLIT-EQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYS---EDLSDMHY 365
+ +V V + + E + + +A+ LA+ + + Y L + L DM Y
Sbjct: 367 LLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEY 426
Query: 366 RVKEKII--------KKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYI 417
I FE + + IL ++ + F V ++
Sbjct: 427 LGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDK----------C 476
Query: 418 KVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDEND 477
+++ + L+ G G + ++++ + + +V+ + + +L +DE
Sbjct: 477 RILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKS 536
Query: 478 TCLVY---DIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGF 534
VY + T E+ P V W D F Y + K T+ H+ +QG
Sbjct: 537 DGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIA--YDDDKVYTYVFHKDTIQGA 594
Query: 535 VVGYNGS---------------KIFC-------------LHVF--SISAVEVPQSAPMY- 563
V GS ++ C H F ++ + PM
Sbjct: 595 KVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLA 654
Query: 564 QYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE 623
Q L K F +A+++ + + W ELA L ++ E A + + R+ ++ ++ S+E
Sbjct: 655 QNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVG---IVMSLE 711
Query: 624 ERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSG 683
+ K G + +L + + ++ A LY S ALEM DL ++ A
Sbjct: 712 QIK--GIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHL 769
Query: 684 DPKETKMLITK---QADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLI---DI 737
P + + + Q ++A + A E I+ G++ + E C G M I DI
Sbjct: 770 APDQIPFISKEYAIQLEFAGDYVNALAHYEKGIT-GDNKEHDEACLA-GVAQMSIRMGDI 827
Query: 738 ARKLDKAEREPLLL----CATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFA 793
R +++A + P + C L+ + AA+ Y K +++ ++ W +
Sbjct: 828 RRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK--- 884
Query: 794 LGEKHPEFKDD-IYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQV-LEQLTN-----NA 846
+G+ P I++ YA+ + R++EA A+ A + + +++ L+ L N N
Sbjct: 885 VGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNI 944
Query: 847 VAESRFNDAA 856
V E++ D A
Sbjct: 945 VRETQSLDGA 954
Score = 38.5 bits (88), Expect = 0.038
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 646 KFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEP 705
+F EAA+LY++ + + A +Y + D L + + K + KE
Sbjct: 855 QFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKE- 913
Query: 706 KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYA 765
AV Y +A + I I DH L+ E+ ++ T + LD
Sbjct: 914 --AVVAYENAKQWQSVIRIYLDH------------LNNPEKAVNIVRET--QSLDGAKMV 957
Query: 766 AETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK------------DDIYMPYAQWL 813
A +L++GD S +Q V ++ +EAF L ++H + + ++ Y A +
Sbjct: 958 ARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYF 1017
Query: 814 AENDRFEEAQKAFHKAGRQREAVQ 837
R+ +A K F G+ A++
Sbjct: 1018 EGEKRYLQAGKFFLLCGQYSRALK 1041
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/280 (23%), Positives = 104/280 (37%), Gaps = 44/280 (15%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 683 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREE 190
++ + C ++ D + LA +G + +W S E
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLK---------------------LWDA---TSANE 777
Query: 191 RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK 250
R I K F L Q + + C S+ G I++ +K T
Sbjct: 778 RKSI------NVKQFFLNLEDPQEDMEVIVK----CCSWSADGARIMVAAKNKIFLWNTD 827
Query: 251 DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQ 290
++ SWV PD + + D TI ++
Sbjct: 828 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716
Score = 48.1 bits (113), Expect = 5e-05
Identities = 34/157 (21%), Positives = 72/157 (45%), Gaps = 12/157 (7%)
Query: 8 RDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKR 67
++ E + ++ DG ++++AA +++ +++T + + +GH V+ V ++ DG
Sbjct: 794 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
Query: 68 FASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSP 121
F + S D+++ +W +K K N A+ + Q LA L +
Sbjct: 854 FLTSSDDQTIRLWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 908
Query: 122 EQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ + + +++ CC + QY+A G NG I I
Sbjct: 909 RTGQID-YLTEAQVSCCCLSPHLQYIAFGDENGAIEI 944
Score = 39.7 bits (91), Expect = 0.017
Identities = 61/308 (19%), Positives = 127/308 (41%), Gaps = 46/308 (14%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 696 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 755
Query: 66 KRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKS 125
K AS SAD ++ +W DA ++ S + F L +
Sbjct: 756 KLLASCSADGTLKLW-------------DATS-------ANERKSINVKQFFL------N 789
Query: 126 VSKHKSSSKII--CCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSIC 183
+ + ++I CCSW+ DG + + N I N + + K+ G LS + +
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL---WNTDSRSKVADCRGHLSWVHGVM 846
Query: 184 WNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSD- 242
++P + + L +D Q + ++ K++ K+ A+ F + E ++L
Sbjct: 847 FSP---DGSSFLTSSD-DQTIRLWET--KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 900
Query: 243 KQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKD 302
+++ L ++ + E + V C P Y+ G ++G I +L+ + + ++
Sbjct: 901 RRLQLINGRTGQIDYLTE--AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI---FQS 955
Query: 303 RYAYRDSM 310
R+ ++ ++
Sbjct: 956 RFQHKKTV 963
Score = 31.2 bits (69), Expect = 6.1
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 984 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1043
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1044 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1101
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/280 (23%), Positives = 104/280 (37%), Gaps = 44/280 (15%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 672 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREE 190
++ + C ++ D + LA +G + +W S E
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLK---------------------LWDA---TSANE 766
Query: 191 RNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTK 250
R I K F L Q + + C S+ G I++ +K T
Sbjct: 767 RKSI------NVKQFFLNLEDPQEDMEVIVK----CCSWSADGARIMVAAKNKIFLWNTD 816
Query: 251 DGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQ 290
++ SWV PD + + D TI ++
Sbjct: 817 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705
Score = 48.1 bits (113), Expect = 5e-05
Identities = 34/157 (21%), Positives = 72/157 (45%), Gaps = 12/157 (7%)
Query: 8 RDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKR 67
++ E + ++ DG ++++AA +++ +++T + + +GH V+ V ++ DG
Sbjct: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
Query: 68 FASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSP 121
F + S D+++ +W +K K N A+ + Q LA L +
Sbjct: 843 FLTSSDDQTIRLWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 897
Query: 122 EQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+ + + +++ CC + QY+A G NG I I
Sbjct: 898 RTGQID-YLTEAQVSCCCLSPHLQYIAFGDENGAIEI 933
Score = 39.7 bits (91), Expect = 0.017
Identities = 61/308 (19%), Positives = 127/308 (41%), Gaps = 46/308 (14%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 685 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 744
Query: 66 KRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKS 125
K AS SAD ++ +W DA ++ S + F L +
Sbjct: 745 KLLASCSADGTLKLW-------------DATS-------ANERKSINVKQFFL------N 778
Query: 126 VSKHKSSSKII--CCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSIC 183
+ + ++I CCSW+ DG + + N I N + + K+ G LS + +
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL---WNTDSRSKVADCRGHLSWVHGVM 835
Query: 184 WNPSREERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSD- 242
++P + + L +D Q + ++ K++ K+ A+ F + E ++L
Sbjct: 836 FSP---DGSSFLTSSD-DQTIRLWET--KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 889
Query: 243 KQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKD 302
+++ L ++ + E + V C P Y+ G ++G I +L+ + + ++
Sbjct: 890 RRLQLINGRTGQIDYLTE--AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI---FQS 944
Query: 303 RYAYRDSM 310
R+ ++ ++
Sbjct: 945 RFQHKKTV 952
Score = 31.2 bits (69), Expect = 6.1
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 973 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1032
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1033 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1090
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 683 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
++ + C ++ D + LA +G + +
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLKL 769
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716
Score = 37.0 bits (84), Expect = 0.11
Identities = 32/146 (21%), Positives = 61/146 (41%), Gaps = 13/146 (8%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F P ++A + +++T + + +GH V+ V ++ DG F + S D+++
Sbjct: 848 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 907
Query: 79 IWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSPEQKSVSKHKSS 132
+W +K K N A+ + Q LA L + + + +
Sbjct: 908 LWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID-YLTE 961
Query: 133 SKIICCSWTNDGQYLALGMFNGIISI 158
+++ CC + QY+A G NG I I
Sbjct: 962 AQVSCCCLSPHLQYIAFGDENGAIEI 987
Score = 31.6 bits (70), Expect = 4.7
Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 3/75 (4%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 696 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 755
Query: 66 KRFASGSADKSVIIW 80
K AS SAD ++ +W
Sbjct: 756 KLLASCSADGTLKLW 770
Score = 31.2 bits (69), Expect = 6.1
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 1027 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1086
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1087 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1144
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 55.1 bits (131), Expect = 4e-07
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F DG ++ + L V+ G L +K H+D V C A++ D + A+ S DK V
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 79 IWTSKLEGILKYT---HNDAIQCVSY-NPITHQLASCSSSD--FGLWSPEQKSV--SKHK 130
IW S + G L +T H++ + C + N H L + SSD LW QK +
Sbjct: 672 IWNS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
++ + C ++ D + LA +G + +
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLKL 758
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/106 (26%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKL-EGILKY-THNDAIQCVSYNPITH 106
++ H D VY +++DG+R AS ADK++ ++ ++ E +L+ H D + C +++
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
Query: 107 QLASCS-SSDFGLWSPEQKSV--SKHKSSSKIICCSWTNDGQYLAL 149
+A+CS +W+ + + + S ++ CC +TN +L L
Sbjct: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705
Score = 37.0 bits (84), Expect = 0.11
Identities = 32/146 (21%), Positives = 61/146 (41%), Gaps = 13/146 (8%)
Query: 20 FKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F P ++A + +++T + + +GH V+ V ++ DG F + S D+++
Sbjct: 837 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 896
Query: 79 IWTSKLEGILKYTHNDAIQCVSYNPITHQ------LASCSSSDFGLWSPEQKSVSKHKSS 132
+W +K K N A+ + Q LA L + + + +
Sbjct: 897 LWETK-----KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID-YLTE 950
Query: 133 SKIICCSWTNDGQYLALGMFNGIISI 158
+++ CC + QY+A G NG I I
Sbjct: 951 AQVSCCCLSPHLQYIAFGDENGAIEI 976
Score = 31.6 bits (70), Expect = 4.7
Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 3/75 (4%)
Query: 9 DKAEHCINDIAFKPDGTQLILAAGSR---LLVYDTSDGTLLQPLKGHKDTVYCVAYAKDG 65
D+ +N F L+LA GS L ++D + + GH ++V ++ D
Sbjct: 685 DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDD 744
Query: 66 KRFASGSADKSVIIW 80
K AS SAD ++ +W
Sbjct: 745 KLLASCSADGTLKLW 759
Score = 31.2 bits (69), Expect = 6.1
Identities = 29/118 (24%), Positives = 49/118 (41%), Gaps = 11/118 (9%)
Query: 4 VLTWRDKAEHCINDIAFKPDGTQLILAAGSRLL---------VYDTSDGTLLQPLKGHKD 54
+ W + + CI + L SRLL V++ G + H+
Sbjct: 1016 IQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQG 1075
Query: 55 TVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLAS 110
TV + D +F+S SADK+ IW+ L L HN ++C +++ + LA+
Sbjct: 1076 TVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1133
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 54.7 bits (130), Expect = 5e-07
Identities = 38/101 (37%), Positives = 54/101 (53%), Gaps = 7/101 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLLVY--DTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGS 72
+N AF PDG Q++L VY +T G LL L GH V ++ DG FAS S
Sbjct: 24 VNSSAFSPDG-QMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 73 ADKSVIIW---TSKLEGILKYTHNDAIQCVSYNPITHQLAS 110
D +V +W +K +LK H +++ VS++P + QLAS
Sbjct: 83 CDCTVRLWDVARAKCLRVLK-GHQRSVETVSFSPDSRQLAS 122
Score = 53.5 bits (127), Expect = 1e-06
Identities = 42/148 (28%), Positives = 73/148 (49%), Gaps = 10/148 (6%)
Query: 20 FKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVI 78
F PDG A+ + ++D + L+ LKGH+ +V V+++ D ++ ASG DK V+
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 79 IWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCS-SSDFGLW-----SPEQKSVSKHK 130
+W + +L+ H D+IQ ++P + LA+ S S +W +P +
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEG 190
Query: 131 SSSKIICCSWTNDGQYLALGMFNGIISI 158
S+ I C ++ G LA G ++ I I
Sbjct: 191 HSANISCLCYSASG-LLASGSWDKTIHI 217
Score = 45.4 bits (106), Expect = 3e-04
Identities = 25/63 (39%), Positives = 36/63 (57%), Gaps = 1/63 (1%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+ IAF PD L A SR++ V+D + G L+ LKG D + A+ DGK SG+A
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
Query: 74 DKS 76
D++
Sbjct: 296 DQT 298
Score = 31.2 bits (69), Expect = 6.1
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 10/78 (12%)
Query: 28 ILAAGS---RLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIW---T 81
+LA+GS + ++ + +LL LKGH V +A++ D AS + V +W T
Sbjct: 205 LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264
Query: 82 SK----LEGILKYTHNDA 95
K L+G+L H A
Sbjct: 265 GKCLETLKGVLDVAHTCA 282
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 54.7 bits (130), Expect = 5e-07
Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+D+A+ D ++L+ A+ + L ++D G L+ LKGH + V+C + SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 74 DKSVIIWTSKLEGILK--YTHNDAIQCVSYN 102
D++V IW K LK H+D + V +N
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFN 176
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/152 (24%), Positives = 73/152 (48%), Gaps = 10/152 (6%)
Query: 15 INDIAFKPDGTQLILAAGSRLLV-YDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
++ + F P+G L ++ RL++ + DG + L GH + VA++ D R S S
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 74 DKSVIIWTSKLEGILKYT--HNDAIQCVSYNPITHQLASCSSSD-FGLWSPEQ----KSV 126
DK++ +W + LK H++ + C ++NP ++ + S S + +W + K++
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 127 SKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
S H S + + G + G ++G+ I
Sbjct: 164 SAH--SDPVSAVHFNCSGSLIVSGSYDGLCRI 193
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/118 (29%), Positives = 56/118 (47%), Gaps = 11/118 (9%)
Query: 49 LKGHKDTVYCVAYAKDGKRFASGSADKSVIIW---TSKLEGILKYTHNDAIQCVSYNPIT 105
L GH + V V ++ +G+ AS SAD+ +IIW K E L Y HN I V+++ +
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDS 95
Query: 106 HQLASCS-SSDFGLWSPEQ----KSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISI 158
+L S S LW K++ H S+ + CC++ + G F+ + I
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGH--SNYVFCCNFNPPSNLIISGSFDETVKI 151
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 6/104 (5%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCV---AYAKDGKRFAS 70
++ + F P+G ++ A + L ++D S G L+ GHK+ YC+ GK S
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVS 272
Query: 71 GSADKSVIIWTSKLEGILK--YTHNDAIQCVSYNPITHQLASCS 112
GS D V IW + + I++ H D + + +P + +AS +
Sbjct: 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 35.0 bits (79), Expect = 0.42
Identities = 32/141 (22%), Positives = 59/141 (41%), Gaps = 9/141 (6%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKY---THN 93
+++ G L+ L H D V V + G SGS D IW + LK N
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDN 210
Query: 94 DAIQCVSYNPI-THQLASCSSSDFGLWSPEQ----KSVSKHKSSSKIICCSWT-NDGQYL 147
+ V ++P + L + + LW + K+ + HK+ I +++ G+++
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWI 270
Query: 148 ALGMFNGIISIRNKNGEEKVK 168
G + ++ I N +E V+
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQ 291
>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
Length = 1749
Score = 53.9 bits (128), Expect = 9e-07
Identities = 56/235 (23%), Positives = 93/235 (39%), Gaps = 22/235 (9%)
Query: 597 GLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKR 656
GL + A+ R + L EL+ I +GE + A L+++
Sbjct: 777 GLPAKAARLVLTREELLANTELVEHITAALIKGEL---------------YERAGDLFEK 821
Query: 657 SGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAG 716
+ ALE Y F A + P E L D K+ AA+ YI A
Sbjct: 822 IHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDHLVQQKQLDAAINHYIEAR 881
Query: 717 EHVKAIEIC-GDHGW--VDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMG 773
+KAIE G W ++D+ + ++ PL+ A + L A E Y K
Sbjct: 882 CSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLV--AQHYASLQEYEIAEELYTKGD 939
Query: 774 DLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 826
K + ++ + RW++A L K PE +Y+ AQ + + ++ EA++ +
Sbjct: 940 RTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEMEKQGKYREAERLY 994
Score = 52.8 bits (125), Expect = 2e-06
Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)
Query: 644 QGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDP---KETKMLITKQADWAR 700
QGK+ EA +LY +LA+ MY +++ +G P +T + + K+ +
Sbjct: 984 QGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEG 1043
Query: 701 NIKEP----------KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLL 750
++E KA V MY ++G +A + G + +A
Sbjct: 1044 RLQEAEYHYLEAQEWKATVNMYRASGLWEEAYRVARTQGGANAHKHVA------------ 1091
Query: 751 LCATYLKKLDSPGYAAETYL-KMGDLKSLVQLHVETQRWDEAFALGEKHPEFKD-DIYMP 808
YL G AA L K+G L++ V + ++ AF L + K ++++
Sbjct: 1092 ----YLWAKSLGGEAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLK 1147
Query: 809 YAQWLAENDRFEEAQKAFHKAGRQREAV 836
YA +L + +FEEA+ F +AG+ +EAV
Sbjct: 1148 YAMFLEDEGKFEEAEAEFIRAGKPKEAV 1175
Score = 35.0 bits (79), Expect = 0.42
Identities = 55/264 (20%), Positives = 110/264 (41%), Gaps = 34/264 (12%)
Query: 44 TLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDA-------- 95
TLL P G V C+A++++ +FA + D+ V+++ E K++ A
Sbjct: 8 TLLSPQDGAAK-VTCMAWSQNNAKFAVCTVDRVVLLYDEHGERRDKFSTKPADMKYGRKS 66
Query: 96 --IQCVSYNPITHQLASCSSSDFGL-------WSPEQKSVSKHKSSSKIICCSWTNDGQY 146
++ ++++P + ++A + + W ++ +K +S + C W +
Sbjct: 67 YMVKGMAFSPDSTKIAIGQTDNIIYVYKIGEDWGDKKVICNKFIQTSAVTCLQWPAE-YI 125
Query: 147 LALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVADWGQKVSF 206
+ G+ G + + N + I G+ S + S+ N S + IL+ G V +
Sbjct: 126 IVFGLAEGKVRLANTKTNKSSTIY---GTESYVVSLTTNCSGK---GILSGHADGTIVRY 179
Query: 207 Y---QLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTV----G 259
+ + SG+ GK P +++ T I+ G D+++ + K+G L T
Sbjct: 180 FFDDEGSGESQGKLVNHPCPPYALAWATNS--IVAAGCDRKIVAYGKEGHMLQTFDYSRD 237
Query: 260 EQNSWVWTCQAKPDSNYVVVGCQD 283
Q T + P VV+G D
Sbjct: 238 PQEREFTTAVSSPGGQSVVLGSYD 261
Score = 34.7 bits (78), Expect = 0.55
Identities = 54/252 (21%), Positives = 102/252 (40%), Gaps = 33/252 (13%)
Query: 600 FETAKKAFIRVQDLRYLELI----SSIEERKKRGETNNDLFLADVFSYQGK-------FH 648
FE A+ FIR + L+ E ++ E ++ +A+V Q + F
Sbjct: 1158 FEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVGQARGALEEKDFQ 1217
Query: 649 EAAKLYKRSGHENLALEMYTDLCMFEYA----KDFLGS---GDPKETKMLITKQADWARN 701
+A L R+ LAL Y + ++ A KD++ S +E + TK+ AR
Sbjct: 1218 KAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKG--ARG 1275
Query: 702 IKEPKAAVEMYISAGEHVKAIEI------CGDHGWVDMLIDIARKLD------KAEREPL 749
++ + AGE+ +A++ G+ G + A +L + E +
Sbjct: 1276 VEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQRNMEVV 1335
Query: 750 LLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALG-EKHPEFKDDIYMP 808
L L + AAE YL + +K + +E + W++A + E P ++D +
Sbjct: 1336 LAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQH 1395
Query: 809 YAQWLAENDRFE 820
Y ++L + +
Sbjct: 1396 YKEFLKNQGKVD 1407
Score = 31.6 bits (70), Expect = 4.7
Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 769 YLKMGDLKSLVQLHVETQRWDEAFALGEK--HPEFKDDIYMPYAQWLAENDRFEEAQKAF 826
+L+ ++ + ++ E RWDE A+ E HP + + Y QWL + + E A +
Sbjct: 702 FLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPAL-EKLRRSYYQWLMDTQQEERAGELQ 760
Query: 827 HKAGRQREAVQV 838
G A+ +
Sbjct: 761 ESQGDGLAAISL 772
Score = 31.6 bits (70), Expect = 4.7
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 17/107 (15%)
Query: 635 LFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITK 694
+FL D +GKF EA + R+G A+ M+ +E A+ + DP ++
Sbjct: 1150 MFLED----EGKFEEAEAEFIRAGKPKEAVLMFVHNQDWEAAQRVAEAHDPDSVAEVLVG 1205
Query: 695 QADWARNIKE-------------PKAAVEMYISAGEHVKAIEICGDH 728
QA A K+ P A+ Y AG A+ IC D+
Sbjct: 1206 QARGALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDY 1252
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 53.1 bits (126), Expect = 2e-06
Identities = 26/67 (38%), Positives = 41/67 (61%), Gaps = 1/67 (1%)
Query: 15 INDIAFKPDGTQLILAA-GSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
I+ + F P+G L A R+L++D G ++ LKGH DTV + +++DG+ ASGS
Sbjct: 672 IHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSM 731
Query: 74 DKSVIIW 80
D +V +W
Sbjct: 732 DNTVRLW 738
Score = 37.7 bits (86), Expect = 0.065
Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 5/102 (4%)
Query: 15 INDIAFKPDGTQLILAAGSRLL-VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSA 73
+N F P+ + + R + ++D +G ++ GHK ++ + ++ +G+ A+G+
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGAT 689
Query: 74 DKSVIIWT---SKLEGILKYTHNDAIQCVSYNPITHQLASCS 112
D V++W + G LK H D + + ++ LAS S
Sbjct: 690 DGRVLLWDIGHGLMVGELK-GHTDTVCSLRFSRDGEILASGS 730
Score = 36.2 bits (82), Expect = 0.19
Identities = 43/218 (19%), Positives = 86/218 (39%), Gaps = 12/218 (5%)
Query: 37 VYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWT-SKLEGILKYT-HND 94
+ D + L+ L GH VY +++ D S S D +V +W+ ++ Y HN
Sbjct: 527 IMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY 586
Query: 95 AIQCVSYNPITHQLASCSSSDFG-LWSPEQKSVSKHKSS--SKIICCSWTNDGQYLALGM 151
+ ++P + S LW+ + + + + + C + + Y+A G
Sbjct: 587 PVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGS 646
Query: 152 FNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSREERNDILAVADWGQKVSFYQLS- 210
+ + + + V+I G PI S+ ++P+ LA +V + +
Sbjct: 647 ADRTVRLWDVLNGNCVRIFT--GHKGPIHSLTFSPN----GRFLATGATDGRVLLWDIGH 700
Query: 211 GKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLF 248
G +G+ + C + + GE + G D V L+
Sbjct: 701 GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,326,255
Number of Sequences: 37866
Number of extensions: 2000401
Number of successful extensions: 5517
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 4558
Number of HSP's gapped (non-prelim): 874
length of query: 1182
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1069
effective length of database: 13,968,660
effective search space: 14932497540
effective search space used: 14932497540
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.