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Search of human proteins with 164664508
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 917 0.0
gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 169 5e-42
gi|117320531 nuclear factor of kappa light polypeptide gene enha... 149 4e-36
gi|117320540 nuclear factor of kappa light polypeptide gene enha... 149 4e-36
gi|117320527 nuclear factor of kappa light polypeptide gene enha... 149 4e-36
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 129 5e-30
gi|53832024 nuclear factor of kappa light polypeptide gene enhan... 113 4e-25
gi|13899229 nuclear factor of kappa light polypeptide gene enhan... 113 4e-25
gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 110 3e-24
gi|41281709 nuclear factor of kappa light polypeptide gene enhan... 106 4e-23
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 104 1e-22
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 102 5e-22
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 102 5e-22
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 102 5e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 101 2e-21
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 100 3e-21
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 100 3e-21
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 100 3e-21
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 100 3e-21
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 100 3e-21
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 100 3e-21
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 99 8e-21
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 99 1e-20
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 99 1e-20
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 99 1e-20
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 99 1e-20
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 99 1e-20
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 98 2e-20
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 94 3e-19
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 94 3e-19
>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
Length = 454
Score = 917 bits (2369), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPL 60
MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPL
Sbjct: 1 MPRCPAGAMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPL 60
Query: 61 RGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHP 120
RGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHP
Sbjct: 61 RGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHP 120
Query: 121 LSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV 180
LSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV
Sbjct: 121 LSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV 180
Query: 181 ITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNY 240
ITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNY
Sbjct: 181 ITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNY 240
Query: 241 DGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGA 300
DGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGA
Sbjct: 241 DGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGA 300
Query: 301 NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG 360
NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG
Sbjct: 301 NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG 360
Query: 361 KATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPN 420
KATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPN
Sbjct: 361 KATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPN 420
Query: 421 FFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS 454
FFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS
Sbjct: 421 FFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS 454
>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, epsilon [Homo sapiens]
Length = 500
Score = 169 bits (428), Expect = 5e-42
Identities = 110/263 (41%), Positives = 145/263 (55%), Gaps = 17/263 (6%)
Query: 92 YPTRAMGSPF---PLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNL 148
Y +G P P LP P + P + + T EDGDT +H+AV+
Sbjct: 219 YTLSLLGGPEAEDPAPRLPLPHVGALSPQQ------LEALTYISEDGDTLVHLAVIH-EA 271
Query: 149 PAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTA 208
PAV L L LDI NNL QT LHLAV P VR LV GAS DRHG TA
Sbjct: 272 PAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTA 330
Query: 209 AHLACEHRSPTCLRALLDSAA-PG-----TLDLEARNYDGLTALHVAVNTECQETVQLLL 262
H+AC+ + C R LL+ PG +LDL+ +N+ GL LH+A + Q ++LLL
Sbjct: 331 LHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLL 390
Query: 263 ERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLL 322
GADID + SG++ L AVE +VQ LLQ GA V+A+M +G + LH A+GRGL+
Sbjct: 391 RNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLM 450
Query: 323 PLVRTLVRSGADSSLKNCHNDTP 345
+ TL ++GADS L+N ++TP
Sbjct: 451 GISSTLCKAGADSLLRNVEDETP 473
Score = 32.7 bits (73), Expect = 0.70
Identities = 25/74 (33%), Positives = 35/74 (47%), Gaps = 2/74 (2%)
Query: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339
+IH L + LL Q ++ +Y +ALH A VR LV GA +L++
Sbjct: 267 VIHEAPAVLLCCLALLPQEVLDIQNNLYQ--TALHLAVHLDQPGAVRALVLKGASRALQD 324
Query: 340 CHNDTPLMVARSRR 353
H DT L VA R+
Sbjct: 325 RHGDTALHVACQRQ 338
Score = 29.3 bits (64), Expect = 7.7
Identities = 25/80 (31%), Positives = 32/80 (40%), Gaps = 4/80 (5%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G T LH+AV LV Q G ++D TPLHLA L + L A
Sbjct: 404 GKTALHLAVETQE----RGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKA 459
Query: 195 GASPMALDRHGQTAAHLACE 214
GA + + +T L E
Sbjct: 460 GADSLLRNVEDETPQDLTEE 479
>gi|117320531 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform a [Homo sapiens]
Length = 900
Score = 149 bits (377), Expect = 4e-36
Identities = 108/313 (34%), Positives = 158/313 (50%), Gaps = 47/313 (15%)
Query: 127 MATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQ--QGGRELDIYNNLRQTPLHLAVITTL 184
+ T DE+GDTPLH+A++ G + ++V + Q +++ N+L QTPLHLAVIT
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539
Query: 185 PSVVRLLVTAGASPMALDRHGQTAAHLACE--HRSPTCLRALLDSAAPGTLD-LEARNYD 241
SVV L+ GA P LDRHG +A HLA +P LRALL S AP L +++
Sbjct: 540 TSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE 599
Query: 242 GLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV-QLLLQHGA 300
GL +H+AV E + LL++ GA+++A + + GR+ L A E L +V L+ + A
Sbjct: 600 GLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRA 659
Query: 301 NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG 360
NVNA+ ++G++ LH A+G G L R L+++GAD + N+ PL S
Sbjct: 660 NVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADI---HAENEEPLCPLPS--------- 707
Query: 361 KATRPASTSQPDPSPDRSANTSPESSSRLSSNG---------------LLSASPSSSPSQ 405
P S S + PE +R S G LL+A+ + +
Sbjct: 708 ----------PPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQN---TM 754
Query: 406 SPPRDPPGFPMAP 418
PP PP P P
Sbjct: 755 EPPLTPPS-PAGP 766
>gi|117320540 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 149 bits (377), Expect = 4e-36
Identities = 108/313 (34%), Positives = 158/313 (50%), Gaps = 47/313 (15%)
Query: 127 MATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQ--QGGRELDIYNNLRQTPLHLAVITTL 184
+ T DE+GDTPLH+A++ G + ++V + Q +++ N+L QTPLHLAVIT
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539
Query: 185 PSVVRLLVTAGASPMALDRHGQTAAHLACE--HRSPTCLRALLDSAAPGTLD-LEARNYD 241
SVV L+ GA P LDRHG +A HLA +P LRALL S AP L +++
Sbjct: 540 TSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE 599
Query: 242 GLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV-QLLLQHGA 300
GL +H+AV E + LL++ GA+++A + + GR+ L A E L +V L+ + A
Sbjct: 600 GLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRA 659
Query: 301 NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG 360
NVNA+ ++G++ LH A+G G L R L+++GAD + N+ PL S
Sbjct: 660 NVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADI---HAENEEPLCPLPS--------- 707
Query: 361 KATRPASTSQPDPSPDRSANTSPESSSRLSSNG---------------LLSASPSSSPSQ 405
P S S + PE +R S G LL+A+ + +
Sbjct: 708 ----------PPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQN---TM 754
Query: 406 SPPRDPPGFPMAP 418
PP PP P P
Sbjct: 755 EPPLTPPS-PAGP 766
>gi|117320527 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 149 bits (377), Expect = 4e-36
Identities = 108/313 (34%), Positives = 158/313 (50%), Gaps = 47/313 (15%)
Query: 127 MATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQ--QGGRELDIYNNLRQTPLHLAVITTL 184
+ T DE+GDTPLH+A++ G + ++V + Q +++ N+L QTPLHLAVIT
Sbjct: 480 LLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQ 539
Query: 185 PSVVRLLVTAGASPMALDRHGQTAAHLACE--HRSPTCLRALLDSAAPGTLD-LEARNYD 241
SVV L+ GA P LDRHG +A HLA +P LRALL S AP L +++
Sbjct: 540 TSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFE 599
Query: 242 GLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV-QLLLQHGA 300
GL +H+AV E + LL++ GA+++A + + GR+ L A E L +V L+ + A
Sbjct: 600 GLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRA 659
Query: 301 NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG 360
NVNA+ ++G++ LH A+G G L R L+++GAD + N+ PL S
Sbjct: 660 NVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADI---HAENEEPLCPLPS--------- 707
Query: 361 KATRPASTSQPDPSPDRSANTSPESSSRLSSNG---------------LLSASPSSSPSQ 405
P S S + PE +R S G LL+A+ + +
Sbjct: 708 ----------PPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQN---TM 754
Query: 406 SPPRDPPGFPMAP 418
PP PP P P
Sbjct: 755 EPPLTPPS-PAGP 766
>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
Length = 969
Score = 129 bits (324), Expect = 5e-30
Identities = 94/261 (36%), Positives = 137/261 (52%), Gaps = 24/261 (9%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQ--GGRELDIYNNLRQTPLHLAVITTLPSVVR 189
DE+GD+ LH+A++ + V L+ + +++ N+L QTPLHLAVIT VV
Sbjct: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
Query: 190 LLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVA 249
L+ AGA LDR G + HLA + L LL L L+ N DGL A+H+A
Sbjct: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL-LDHPNGDGLNAIHLA 659
Query: 250 VNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQ-LLLQHGANVNAQMYS 308
+ + + LL+ GAD++A + KSGR+ L AVE++++S+ LLL+ A+V++ Y
Sbjct: 660 MMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYD 719
Query: 309 GSSALHSASGRGLLPLVRTLVRSGADSSLKNCH--------------------NDTPLMV 348
G++ LH A+GRG L L +GAD ++N TPL +
Sbjct: 720 GTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDM 779
Query: 349 ARSRRVIDILRGKATRPASTS 369
A S +V DIL GK P TS
Sbjct: 780 ATSWQVFDILNGKPYEPEFTS 800
>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform b [Homo sapiens]
Length = 618
Score = 113 bits (282), Expect = 4e-25
Identities = 97/312 (31%), Positives = 140/312 (44%), Gaps = 43/312 (13%)
Query: 93 PTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMAT--RADEDGDTPLHIAVVQGNLPA 150
P MG+P L L+ E A+I+ D DGDT LHIAV QG
Sbjct: 300 PFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRAL 359
Query: 151 VHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAH 210
+ L LDI + Q+ +AV +V+ LV GA D G+T H
Sbjct: 360 SYVLARKMN-ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLH 418
Query: 211 LACEHRSPTCLRALLDSAAPGT--LDLEARNYDGLTALHVAV------------------ 250
+ E L+A+ A +DLEA NYDGLT LH AV
Sbjct: 419 VCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHS 478
Query: 251 ---------NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHG-- 299
N +T++ L++ GA ++A D KSGR+ L A E +L +++L L+
Sbjct: 479 PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSC 538
Query: 300 -ANVNAQMYSGSSALHSASGRGL----LPLVRTLVRSGADSSLKNCHNDTPLMVAR---- 350
+ VNA+ Y+G++ALH A+ L VR L+R GAD S +N N+ P+ +
Sbjct: 539 LSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPV 598
Query: 351 SRRVIDILRGKA 362
++ IL+GK+
Sbjct: 599 GEQIRRILKGKS 610
>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform a [Homo sapiens]
Length = 718
Score = 113 bits (282), Expect = 4e-25
Identities = 97/312 (31%), Positives = 140/312 (44%), Gaps = 43/312 (13%)
Query: 93 PTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMAT--RADEDGDTPLHIAVVQGNLPA 150
P MG+P L L+ E A+I+ D DGDT LHIAV QG
Sbjct: 400 PFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRAL 459
Query: 151 VHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAH 210
+ L LDI + Q+ +AV +V+ LV GA D G+T H
Sbjct: 460 SYVLARKMN-ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLH 518
Query: 211 LACEHRSPTCLRALLDSAAPGT--LDLEARNYDGLTALHVAV------------------ 250
+ E L+A+ A +DLEA NYDGLT LH AV
Sbjct: 519 VCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHS 578
Query: 251 ---------NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHG-- 299
N +T++ L++ GA ++A D KSGR+ L A E +L +++L L+
Sbjct: 579 PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSC 638
Query: 300 -ANVNAQMYSGSSALHSASGRGL----LPLVRTLVRSGADSSLKNCHNDTPLMVAR---- 350
+ VNA+ Y+G++ALH A+ L VR L+R GAD S +N N+ P+ +
Sbjct: 639 LSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPV 698
Query: 351 SRRVIDILRGKA 362
++ IL+GK+
Sbjct: 699 GEQIRRILKGKS 710
>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha [Homo sapiens]
Length = 317
Score = 110 bits (275), Expect = 3e-24
Identities = 71/189 (37%), Positives = 98/189 (51%), Gaps = 2/189 (1%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
EDGD+ LH+A++ ++ + L+ NNL+QTPLHLAVIT P + L+
Sbjct: 72 EDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALL 131
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLD--LEARNYDGLTALHVAV 250
AG P D G T HLACE + L S L L+A NY+G T LH+A
Sbjct: 132 GAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLAS 191
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
V+LL+ GAD++A + +GR+ L AV+ + +V LLL+ GA+VN Y G
Sbjct: 192 IHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGY 251
Query: 311 SALHSASGR 319
S GR
Sbjct: 252 SPYQLTWGR 260
Score = 55.5 bits (132), Expect = 1e-07
Identities = 51/167 (30%), Positives = 72/167 (43%), Gaps = 10/167 (5%)
Query: 192 VTAGASP--MALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVA 249
V G+ P L G + HLA H ++ L +N T LH+A
Sbjct: 59 VPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLA 118
Query: 250 VNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGAN------VN 303
V T E + LL G D + D + G +PL A E L+ V +L Q +
Sbjct: 119 VITNQPEIAEALLGAGCDPELRDFR-GNTPLHLACEQGCLASVGVLTQSCTTPHLHSILK 177
Query: 304 AQMYSGSSALHSASGRGLLPLVRTLVRSGAD-SSLKNCHNDTPLMVA 349
A Y+G + LH AS G L +V LV GAD ++ + C+ T L +A
Sbjct: 178 ATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLA 224
Score = 43.9 bits (102), Expect = 3e-04
Identities = 40/114 (35%), Positives = 53/114 (46%), Gaps = 7/114 (6%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRE--LDIYNNLRQTPLHLAVITTLPSVVR 189
D G+TPLH+A QG L +V L L N T LHLA I +V
Sbjct: 141 DFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVE 200
Query: 190 LLVTAGASPMALDR-HGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDG 242
LLV+ GA A + +G+TA HLA + ++P + LL A D+ Y G
Sbjct: 201 LLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA----DVNRVTYQG 250
>gi|41281709 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, delta [Homo sapiens]
Length = 313
Score = 106 bits (265), Expect = 4e-23
Identities = 86/278 (30%), Positives = 139/278 (50%), Gaps = 40/278 (14%)
Query: 109 PLYPMMCP-------MEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQG 161
P +P + P H L+ DE+GDT LH+ +G A + + Q
Sbjct: 16 PQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVY 75
Query: 162 GRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCL 221
R LDI + +TPL +A P +V L+ GA P A D G++ H+A + P L
Sbjct: 76 -RRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVL 134
Query: 222 RALLDSAAPGTLDLEARNYDGLTALHVAV-----------------NTECQ---ETVQLL 261
A+L+S +DLEAR+++GLT LH A+ +T+ + + V +L
Sbjct: 135 LAVLNSGV--QVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHML 192
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGAN-----VNAQMYSGSSALHSA 316
L+ GA+ + +IKS ++ L AV+ + ++VQLLL+ VN + + G++ALH A
Sbjct: 193 LQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMA 251
Query: 317 S----GRGLLPLVRTLVRSGADSSLKNCHNDTPLMVAR 350
+ G +VR L+ +GAD +L+N N+ P+ + R
Sbjct: 252 AALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLR 289
Score = 36.2 bits (82), Expect = 0.063
Identities = 39/157 (24%), Positives = 59/157 (37%), Gaps = 27/157 (17%)
Query: 132 DEDGDTPLHIAVVQGN--------------------LPAVHRLVNLFQQGGRELDIYNNL 171
D +G TPLH A++ N L VH L+ Q G
Sbjct: 150 DFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLL---QMGANHTSQEIKS 206
Query: 172 RQTPLHLAVITTLPSVVRLLVTAGASPMA----LDRHGQTAAHLACEHRSPTCLRALLDS 227
+T LHLAV P++V+LL+ + + HG TA H+A A++
Sbjct: 207 NKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRH 266
Query: 228 AAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLER 264
D RN + +H+ E ++ LL+R
Sbjct: 267 LLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKR 303
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 104 bits (260), Expect = 1e-22
Identities = 72/218 (33%), Positives = 111/218 (50%), Gaps = 9/218 (4%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D++ TPLH A G++P ++ L G ++ + L TPLH A + V+ LL
Sbjct: 38 DQERRTPLHAAAYVGDVP----ILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVN 251
+ A A D+ QT H+A +R+ C AL AP L + G +ALH AV+
Sbjct: 94 LAHSADVNARDKLWQTPLHVAAANRATKCAEAL----APLLSSLNVADRSGRSALHHAVH 149
Query: 252 TECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSS 311
+ ETV LLL +GA ++ D K R PL A L +++LL+ GA++ + G
Sbjct: 150 SGHLETVNLLLNKGASLNVCD-KKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYG 208
Query: 312 ALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH+A+ G + +V+ L+R GA+ N +T L +A
Sbjct: 209 LLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Score = 86.7 bits (213), Expect = 4e-17
Identities = 69/220 (31%), Positives = 106/220 (48%), Gaps = 10/220 (4%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
AD G + LH AV G+L V+ L+N G L++ + + PLH A V++L
Sbjct: 136 ADRSGRSALHHAVHSGHLETVNLLLN----KGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
LV GA DR G H A ++ LL A +++ N G TALH+A
Sbjct: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGA----EIDEPNAFGNTALHIAC 247
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPL-IHAVENNSLSMVQLLLQHGANVNAQMYSG 309
L+ GA+++ + K G +PL + AV N ++LL+ +GA+VN Q G
Sbjct: 248 YLGQDAVAIELVNAGANVNQPNDK-GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEG 306
Query: 310 SSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
S LH A+ G + L+++G++ + +TPL VA
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/229 (29%), Positives = 94/229 (41%), Gaps = 24/229 (10%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ L ++ + AD ++G +PLH+A + G L+ Q G
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI----QNG 329
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
E+D + TPLH+A ++ L+T GA H HLA C R
Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCR 389
Query: 223 ALLDSAAPGTL--------------DLEARNYDGLTALHVAVNTECQETVQLLLERGADI 268
LL S ++ D+ + G T LH A + E + LLL GAD+
Sbjct: 390 KLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADL 449
Query: 269 DAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSAS 317
D K GR+PL +A N S L+ GA VN G S LH A+
Sbjct: 450 RRRD-KFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAA 497
Score = 77.0 bits (188), Expect = 3e-14
Identities = 62/208 (29%), Positives = 98/208 (47%), Gaps = 5/208 (2%)
Query: 165 LDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRAL 224
+++ + R+TPLH A +++LL+ +GA+ A D T H A R+ L L
Sbjct: 34 INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93
Query: 225 LDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAV 284
L +A D+ AR+ T LHVA + + L + ++ D +SGRS L HAV
Sbjct: 94 LAHSA----DVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD-RSGRSALHHAV 148
Query: 285 ENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDT 344
+ L V LLL GA++N LH A+ G L +++ LV GAD K+
Sbjct: 149 HSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYG 208
Query: 345 PLMVARSRRVIDILRGKATRPASTSQPD 372
L A + I++++ A +P+
Sbjct: 209 LLHTAAASGQIEVVKYLLRMGAEIDEPN 236
Score = 74.7 bits (182), Expect = 2e-13
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 7/249 (2%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D G T +H A GN + L+ + D+ + + +PLHLA ++ L
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE--DVESTIPVSPLHLAAYNGHCEALKTL 604
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVN 251
+ D G+TA LA E S C+ L A + R + T LH A
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKW---TPLHAAAA 661
Query: 252 TECQETVQLLLERGADIDAVDIKS--GRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSG 309
+ +++ LL++ G D D+ G++PL+ A+ N + V LLL+ G+ +A G
Sbjct: 662 SGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRG 721
Query: 310 SSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTS 369
+ALH + G + L+ A ++ TP+ +A + +LR ST
Sbjct: 722 RTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD 781
Query: 370 QPDPSPDRS 378
D D S
Sbjct: 782 PLDAGVDYS 790
Score = 72.8 bits (177), Expect = 6e-13
Identities = 73/256 (28%), Positives = 115/256 (44%), Gaps = 40/256 (15%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D G TPL +A++ G++ VH L+ + G D + +T LH +T + L
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLL----EKGSTADAADLRGRTALHRGAVTGCEDCLAAL 740
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEAR-NYDGLTALHVAV 250
+ A + D G+T HLA LR LL AA T L+A +Y G + +H A
Sbjct: 741 LDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ-AALSTDPLDAGVDYSGYSPMHWAS 799
Query: 251 NTECQETVQLLLER---------------------------------GADIDAVDIKSGR 277
T ++ ++LLLE GA I GR
Sbjct: 800 YTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGR 859
Query: 278 SPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLV-RSGADSS 336
+PL A +++S +++LLQH A VNA ++G +AL +A+ G V L+ R AD +
Sbjct: 860 TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLT 919
Query: 337 LKNCHNDTPLMVARSR 352
+ + + +T L +A S+
Sbjct: 920 VLDENKNTALHLACSK 935
Score = 59.7 bits (143), Expect = 5e-09
Identities = 70/252 (27%), Positives = 104/252 (41%), Gaps = 39/252 (15%)
Query: 130 RADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTL----- 184
R D+ G TPLH A G+ LV G E D +PLH A +
Sbjct: 451 RRDKFGRTPLHYAAANGSYQCAVTLVTA-GAGVNEADCKGC---SPLHYAAASDTYRRAE 506
Query: 185 ---PS--------------------VVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCL 221
PS + L+ GA P DR G TA H A + + L
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL 566
Query: 222 RALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLI 281
LL+ + D+E+ ++ LH+A E ++ L E ++D D K GR+ L
Sbjct: 567 ELLLEMSFNCLEDVEST--IPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHK-GRTALF 623
Query: 282 HAVENNSLSMVQLLLQHGANVNAQMYSGS-SALHSASGRGLLPLVRTLVRSG--AD-SSL 337
A E S V++L HGA+ + + LH+A+ G + L+ SG AD + +
Sbjct: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683
Query: 338 KNCHNDTPLMVA 349
+ + TPLM+A
Sbjct: 684 MDAYGQTPLMLA 695
Score = 54.7 bits (130), Expect = 2e-07
Identities = 74/274 (27%), Positives = 115/274 (41%), Gaps = 26/274 (9%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D G +P+H A G+ + L+ E + + TPLH AVI S +L
Sbjct: 788 DYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-----TPLHCAVINNQDSTTEML 842
Query: 192 VTAGASPM--ALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVA 249
+ A + + + D G+T H A + + LR LL A ++ A ++ G TAL A
Sbjct: 843 LGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQA----EVNATDHTGRTALMTA 898
Query: 250 VNTECQETVQLLLERG-ADIDAVDIKSGRSPLIHAVENNSLSMVQLLL----QHGANVNA 304
V+ LL RG AD+ +D ++ +H + L++ Q +NA
Sbjct: 899 AENGQTAAVEFLLYRGKADLTVLD--ENKNTALHLACSKGHEKCALMILAETQDLGLINA 956
Query: 305 QMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP-LMVARSRRVIDILRGKAT 363
+ LH A+ GL +V+ L+ GA + TP L A ++ V D L
Sbjct: 957 TNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCL----A 1012
Query: 364 RPASTSQPDPSPDRSANTSPESSSRLSSNGLLSA 397
ST +P P D SP S S L + + +A
Sbjct: 1013 LILSTMKPFPPKDA---VSPFSFSLLKNCSIAAA 1043
Score = 53.1 bits (126), Expect = 5e-07
Identities = 58/236 (24%), Positives = 90/236 (38%), Gaps = 55/236 (23%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
AD+ G+TPLH+A G+ L++ G + PLHLAV+ R
Sbjct: 335 ADKFGNTPLHVAARYGH----ELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRK 390
Query: 191 LVTAGASPMAL------------------DRHGQTAAHLACEHRSPTCLRALLDSAAPGT 232
L+++G + D G+T H A + CL LL S A
Sbjct: 391 LLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGA--- 447
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSM- 291
DL R+ G T LH A + L+ GA ++ D K G SPL +A +++
Sbjct: 448 -DLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK-GCSPLHYAAASDTYRRA 505
Query: 292 ---------------------------VQLLLQHGANVNAQMYSGSSALHSASGRG 320
++ LL +GA+ + + G +A+H A+ G
Sbjct: 506 EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561
Score = 48.5 bits (114), Expect = 1e-05
Identities = 35/104 (33%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 129 TRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVV 188
T DE+ +T LH+A +G+ ++ Q G ++ N+ Q PLH+A L SVV
Sbjct: 919 TVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVV 977
Query: 189 RLLVTAGASPMALDRHGQTAAHLACEHRSPT--CLRALLDSAAP 230
+ L++ GA+ +A+D G T A LAC CL +L + P
Sbjct: 978 QALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILSTMKP 1020
Score = 46.6 bits (109), Expect = 5e-05
Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 1/156 (0%)
Query: 256 ETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHS 315
E V+ LL + +I+ +D + R+PL A + ++QLLL GANVNA+ + LH
Sbjct: 22 EEVRSLLSQKENINVLD-QERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80
Query: 316 ASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSP 375
A+ ++ L+ AD + ++ TPL VA + R A +S + D S
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140
Query: 376 DRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDP 411
+ + + S + N LL+ S + R P
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP 176
Score = 38.9 bits (89), Expect = 0.010
Identities = 24/83 (28%), Positives = 46/83 (55%), Gaps = 3/83 (3%)
Query: 279 PLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLK 338
PL+ A+ + + V+ LL N+N + LH+A+ G +P+++ L+ SGA+ + K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 339 NCHNDTPL---MVARSRRVIDIL 358
+ TPL +R+ +V+ +L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLL 93
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 102 bits (255), Expect = 5e-22
Identities = 70/226 (30%), Positives = 121/226 (53%), Gaps = 9/226 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLH+A +GN +V L G ++D TPLH A + VV LL+
Sbjct: 244 NGITPLHVASKRGNT----NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GA +A ++G + H+A + C++ LL AP ++ D LTALHVA +
Sbjct: 300 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP----VDDVTLDYLTALHVAAHCG 355
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
+LLL++ A+ +A + +G +PL A + N + +++LL+++GA++ A SG + +
Sbjct: 356 HYRVTKLLLDKRANPNARAL-NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
H A+ G L +V L+++GA + N +T L +A ++++R
Sbjct: 415 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 460
Score = 99.0 bits (245), Expect = 8e-21
Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 9/233 (3%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A A A ++G TPLH+A N ++ L + G TPLH+A
Sbjct: 566 AAADSAGKNGLTPLHVAAHYDN----QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTA 245
+ L+ GA + + G T HLA + + LLD A ++ GLT+
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA----NIHMSTKSGLTS 677
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
LH+A + +L + GAD DA K G +PLI A ++ MV LL+ GANVNA+
Sbjct: 678 LHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 736
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
+G + LH A+ +G ++ L++ GA + + +T L +A+ I ++
Sbjct: 737 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Score = 90.9 bits (224), Expect = 2e-18
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 38/266 (14%)
Query: 126 AMATRADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQ 160
A + A EDG TPL +A+ QG+ LPA+H + L Q
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 161 GGRELDIYNNLRQ--------TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
D+ + + TPLH+A +V LL+ GA+ R+G T H+A
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 252
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
+ + ++ LLD ++A+ DGLT LH A + + V+LLLERGA + A
Sbjct: 253 SKRGNTNMVKLLLDRGG----QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA-R 307
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
K+G SPL A + + + V+ LLQH A V+ +ALH A+ G + + L+
Sbjct: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 367
Query: 333 ADSSLKNCHNDTPLMVARSRRVIDIL 358
A+ + + + TPL +A + I ++
Sbjct: 368 ANPNARALNGFTPLHIACKKNRIKVM 393
Score = 82.8 bits (203), Expect = 6e-16
Identities = 64/196 (32%), Positives = 95/196 (48%), Gaps = 9/196 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA + + L+N G E +I TPLHLA +V LL+
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNY----GAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA+ + G T+ HLA + L A D +A G T L VA +
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA----DQDAHTKLGYTPLIVACHY 717
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ V LL++GA+++A K+G +PL A + ++ +LLQHGA NA +G++A
Sbjct: 718 GNVKMVNFLLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 776
Query: 313 LHSASGRGLLPLVRTL 328
L A G + +V TL
Sbjct: 777 LAIAKRLGYISVVDTL 792
Score = 80.5 bits (197), Expect = 3e-15
Identities = 62/186 (33%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 174 TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTL 233
TPLH+A V+ LLV GAS A+ G T H+A + LL + A
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP-- 436
Query: 234 DLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQ 293
+ N G TALH+A E V+ LL GA +DA + ++PL A +VQ
Sbjct: 437 --DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA-RAREEQTPLHIASRLGKTEIVQ 493
Query: 294 LLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRR 353
LLLQH A+ +A +G + LH ++ G + + L+ +GA SL TPL VA
Sbjct: 494 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 553
Query: 354 VIDILR 359
+D+ +
Sbjct: 554 SLDVAK 559
Score = 80.1 bits (196), Expect = 4e-15
Identities = 67/225 (29%), Positives = 101/225 (44%), Gaps = 9/225 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
E G TP+H+A G+L +V L Q G D+ N +T LH+A VVR L+
Sbjct: 408 ESGLTPIHVAAFMGHL----NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 463
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A R QT H+A ++ LL A +A +G T LH++
Sbjct: 464 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP----DAATTNGYTPLHISARE 519
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ +LLE GA ++ K G +PL A + SL + +LLLQ A ++ +G +
Sbjct: 520 GQVDVASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 578
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
LH A+ + L+ GA + TPL +A + + I
Sbjct: 579 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623
Score = 68.2 bits (165), Expect = 1e-11
Identities = 62/250 (24%), Positives = 107/250 (42%), Gaps = 36/250 (14%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
+++G LH+A +G++ V L+ G +D T LH+A + VV++L
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGR----GSSVDSATKKGNTALHIASLAGQAEVVKVL 95
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGT------------------- 232
V GA+ A ++G T ++A + ++ LL++ A +
Sbjct: 96 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
Query: 233 ------LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD-------IKSGRSP 279
L+ + + L ALH+A + ++ LLL+ + D +SG +P
Sbjct: 156 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215
Query: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339
L A ++++ LLL GA V+ +G + LH AS RG +V+ L+ G K
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 275
Query: 340 CHNDTPLMVA 349
TPL A
Sbjct: 276 RDGLTPLHCA 285
Score = 65.5 bits (158), Expect = 1e-10
Identities = 41/119 (34%), Positives = 65/119 (54%), Gaps = 1/119 (0%)
Query: 231 GTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLS 290
G +D+ N +GL ALH+A VQ LL RG+ +D+ K G + L A
Sbjct: 32 GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT-KKGNTALHIASLAGQAE 90
Query: 291 MVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+V++L++ GAN+NAQ +G + L+ A+ + +V+ L+ +GA+ S TPL VA
Sbjct: 91 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149
Score = 53.5 bits (127), Expect = 4e-07
Identities = 59/231 (25%), Positives = 97/231 (41%), Gaps = 40/231 (17%)
Query: 158 FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRS 217
+ +GG +++ N LHLA +V+ L+ G+S + + G TA H+A
Sbjct: 29 YLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 88
Query: 218 PTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADID-------- 269
++ L+ A ++ A++ +G T L++A + V+ LLE GA+
Sbjct: 89 AEVVKVLVKEGA----NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 144
Query: 270 --AVDIKSG-----------------RSPLIH-AVENNSLSMVQLLLQ--HGANVNAQMY 307
AV ++ G R P +H A + LLLQ H A+V ++M
Sbjct: 145 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 204
Query: 308 ------SGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
SG + LH A+ G + + L+ GA + TPL VA R
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 255
Score = 51.6 bits (122), Expect = 1e-06
Identities = 31/98 (31%), Positives = 58/98 (59%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L+ G DI+ + ++G + L A + + +VQ LL G++V++ G++ALH AS G
Sbjct: 30 LKGGIDINTCN-QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 88
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+V+ LV+ GA+ + ++ + TPL +A ID+++
Sbjct: 89 AEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 102 bits (255), Expect = 5e-22
Identities = 70/226 (30%), Positives = 121/226 (53%), Gaps = 9/226 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLH+A +GN +V L G ++D TPLH A + VV LL+
Sbjct: 265 NGITPLHVASKRGNT----NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GA +A ++G + H+A + C++ LL AP ++ D LTALHVA +
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP----VDDVTLDYLTALHVAAHCG 376
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
+LLL++ A+ +A + +G +PL A + N + +++LL+++GA++ A SG + +
Sbjct: 377 HYRVTKLLLDKRANPNARAL-NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
H A+ G L +V L+++GA + N +T L +A ++++R
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 481
Score = 99.0 bits (245), Expect = 8e-21
Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 9/233 (3%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A A A ++G TPLH+A N ++ L + G TPLH+A
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDN----QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTA 245
+ L+ GA + + G T HLA + + LLD A ++ GLT+
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA----NIHMSTKSGLTS 698
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
LH+A + +L + GAD DA K G +PLI A ++ MV LL+ GANVNA+
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
+G + LH A+ +G ++ L++ GA + + +T L +A+ I ++
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Score = 90.9 bits (224), Expect = 2e-18
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 38/266 (14%)
Query: 126 AMATRADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQ 160
A + A EDG TPL +A+ QG+ LPA+H + L Q
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 161 GGRELDIYNNLRQ--------TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
D+ + + TPLH+A +V LL+ GA+ R+G T H+A
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
+ + ++ LLD ++A+ DGLT LH A + + V+LLLERGA + A
Sbjct: 274 SKRGNTNMVKLLLDRGG----QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA-R 328
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
K+G SPL A + + + V+ LLQH A V+ +ALH A+ G + + L+
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 333 ADSSLKNCHNDTPLMVARSRRVIDIL 358
A+ + + + TPL +A + I ++
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVM 414
Score = 82.8 bits (203), Expect = 6e-16
Identities = 64/196 (32%), Positives = 95/196 (48%), Gaps = 9/196 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA + + L+N G E +I TPLHLA +V LL+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNY----GAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA+ + G T+ HLA + L A D +A G T L VA +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA----DQDAHTKLGYTPLIVACHY 738
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ V LL++GA+++A K+G +PL A + ++ +LLQHGA NA +G++A
Sbjct: 739 GNVKMVNFLLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Query: 313 LHSASGRGLLPLVRTL 328
L A G + +V TL
Sbjct: 798 LAIAKRLGYISVVDTL 813
Score = 80.5 bits (197), Expect = 3e-15
Identities = 62/186 (33%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 174 TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTL 233
TPLH+A V+ LLV GAS A+ G T H+A + LL + A
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP-- 457
Query: 234 DLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQ 293
+ N G TALH+A E V+ LL GA +DA + ++PL A +VQ
Sbjct: 458 --DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA-RAREEQTPLHIASRLGKTEIVQ 514
Query: 294 LLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRR 353
LLLQH A+ +A +G + LH ++ G + + L+ +GA SL TPL VA
Sbjct: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 354 VIDILR 359
+D+ +
Sbjct: 575 SLDVAK 580
Score = 80.1 bits (196), Expect = 4e-15
Identities = 67/225 (29%), Positives = 101/225 (44%), Gaps = 9/225 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
E G TP+H+A G+L +V L Q G D+ N +T LH+A VVR L+
Sbjct: 429 ESGLTPIHVAAFMGHL----NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A R QT H+A ++ LL A +A +G T LH++
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP----DAATTNGYTPLHISARE 540
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ +LLE GA ++ K G +PL A + SL + +LLLQ A ++ +G +
Sbjct: 541 GQVDVASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
LH A+ + L+ GA + TPL +A + + I
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Score = 68.2 bits (165), Expect = 1e-11
Identities = 62/250 (24%), Positives = 107/250 (42%), Gaps = 36/250 (14%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
+++G LH+A +G++ V L+ G +D T LH+A + VV++L
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGR----GSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGT------------------- 232
V GA+ A ++G T ++A + ++ LL++ A +
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 233 ------LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD-------IKSGRSP 279
L+ + + L ALH+A + ++ LLL+ + D +SG +P
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339
L A ++++ LLL GA V+ +G + LH AS RG +V+ L+ G K
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 340 CHNDTPLMVA 349
TPL A
Sbjct: 297 RDGLTPLHCA 306
Score = 65.5 bits (158), Expect = 1e-10
Identities = 41/119 (34%), Positives = 65/119 (54%), Gaps = 1/119 (0%)
Query: 231 GTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLS 290
G +D+ N +GL ALH+A VQ LL RG+ +D+ K G + L A
Sbjct: 53 GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT-KKGNTALHIASLAGQAE 111
Query: 291 MVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+V++L++ GAN+NAQ +G + L+ A+ + +V+ L+ +GA+ S TPL VA
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 53.5 bits (127), Expect = 4e-07
Identities = 59/231 (25%), Positives = 97/231 (41%), Gaps = 40/231 (17%)
Query: 158 FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRS 217
+ +GG +++ N LHLA +V+ L+ G+S + + G TA H+A
Sbjct: 50 YLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 109
Query: 218 PTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADID-------- 269
++ L+ A ++ A++ +G T L++A + V+ LLE GA+
Sbjct: 110 AEVVKVLVKEGA----NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 165
Query: 270 --AVDIKSG-----------------RSPLIH-AVENNSLSMVQLLLQ--HGANVNAQMY 307
AV ++ G R P +H A + LLLQ H A+V ++M
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 225
Query: 308 ------SGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
SG + LH A+ G + + L+ GA + TPL VA R
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Score = 51.6 bits (122), Expect = 1e-06
Identities = 31/98 (31%), Positives = 58/98 (59%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L+ G DI+ + ++G + L A + + +VQ LL G++V++ G++ALH AS G
Sbjct: 51 LKGGIDINTCN-QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 109
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+V+ LV+ GA+ + ++ + TPL +A ID+++
Sbjct: 110 AEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 102 bits (255), Expect = 5e-22
Identities = 70/226 (30%), Positives = 121/226 (53%), Gaps = 9/226 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLH+A +GN +V L G ++D TPLH A + VV LL+
Sbjct: 265 NGITPLHVASKRGNT----NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GA +A ++G + H+A + C++ LL AP ++ D LTALHVA +
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP----VDDVTLDYLTALHVAAHCG 376
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
+LLL++ A+ +A + +G +PL A + N + +++LL+++GA++ A SG + +
Sbjct: 377 HYRVTKLLLDKRANPNARAL-NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
H A+ G L +V L+++GA + N +T L +A ++++R
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVR 481
Score = 99.0 bits (245), Expect = 8e-21
Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 9/233 (3%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A A A ++G TPLH+A N ++ L + G TPLH+A
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDN----QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTA 245
+ L+ GA + + G T HLA + + LLD A ++ GLT+
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA----NIHMSTKSGLTS 698
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
LH+A + +L + GAD DA K G +PLI A ++ MV LL+ GANVNA+
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK 757
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
+G + LH A+ +G ++ L++ GA + + +T L +A+ I ++
Sbjct: 758 TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Score = 90.9 bits (224), Expect = 2e-18
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 38/266 (14%)
Query: 126 AMATRADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQ 160
A + A EDG TPL +A+ QG+ LPA+H + L Q
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 161 GGRELDIYNNLRQ--------TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
D+ + + TPLH+A +V LL+ GA+ R+G T H+A
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA 273
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
+ + ++ LLD ++A+ DGLT LH A + + V+LLLERGA + A
Sbjct: 274 SKRGNTNMVKLLLDRGG----QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA-R 328
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
K+G SPL A + + + V+ LLQH A V+ +ALH A+ G + + L+
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 333 ADSSLKNCHNDTPLMVARSRRVIDIL 358
A+ + + + TPL +A + I ++
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVM 414
Score = 82.8 bits (203), Expect = 6e-16
Identities = 64/196 (32%), Positives = 95/196 (48%), Gaps = 9/196 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA + + L+N G E +I TPLHLA +V LL+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNY----GAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA+ + G T+ HLA + L A D +A G T L VA +
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA----DQDAHTKLGYTPLIVACHY 738
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ V LL++GA+++A K+G +PL A + ++ +LLQHGA NA +G++A
Sbjct: 739 GNVKMVNFLLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA 797
Query: 313 LHSASGRGLLPLVRTL 328
L A G + +V TL
Sbjct: 798 LAIAKRLGYISVVDTL 813
Score = 80.5 bits (197), Expect = 3e-15
Identities = 62/186 (33%), Positives = 89/186 (47%), Gaps = 5/186 (2%)
Query: 174 TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTL 233
TPLH+A V+ LLV GAS A+ G T H+A + LL + A
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP-- 457
Query: 234 DLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQ 293
+ N G TALH+A E V+ LL GA +DA + ++PL A +VQ
Sbjct: 458 --DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA-RAREEQTPLHIASRLGKTEIVQ 514
Query: 294 LLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRR 353
LLLQH A+ +A +G + LH ++ G + + L+ +GA SL TPL VA
Sbjct: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 354 VIDILR 359
+D+ +
Sbjct: 575 SLDVAK 580
Score = 80.1 bits (196), Expect = 4e-15
Identities = 67/225 (29%), Positives = 101/225 (44%), Gaps = 9/225 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
E G TP+H+A G+L +V L Q G D+ N +T LH+A VVR L+
Sbjct: 429 ESGLTPIHVAAFMGHL----NIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A R QT H+A ++ LL A +A +G T LH++
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP----DAATTNGYTPLHISARE 540
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ +LLE GA ++ K G +PL A + SL + +LLLQ A ++ +G +
Sbjct: 541 GQVDVASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
LH A+ + L+ GA + TPL +A + + I
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Score = 68.2 bits (165), Expect = 1e-11
Identities = 62/250 (24%), Positives = 107/250 (42%), Gaps = 36/250 (14%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
+++G LH+A +G++ V L+ G +D T LH+A + VV++L
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGR----GSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGT------------------- 232
V GA+ A ++G T ++A + ++ LL++ A +
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 233 ------LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD-------IKSGRSP 279
L+ + + L ALH+A + ++ LLL+ + D +SG +P
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339
L A ++++ LLL GA V+ +G + LH AS RG +V+ L+ G K
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 340 CHNDTPLMVA 349
TPL A
Sbjct: 297 RDGLTPLHCA 306
Score = 65.5 bits (158), Expect = 1e-10
Identities = 41/119 (34%), Positives = 65/119 (54%), Gaps = 1/119 (0%)
Query: 231 GTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLS 290
G +D+ N +GL ALH+A VQ LL RG+ +D+ K G + L A
Sbjct: 53 GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT-KKGNTALHIASLAGQAE 111
Query: 291 MVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+V++L++ GAN+NAQ +G + L+ A+ + +V+ L+ +GA+ S TPL VA
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 53.5 bits (127), Expect = 4e-07
Identities = 59/231 (25%), Positives = 97/231 (41%), Gaps = 40/231 (17%)
Query: 158 FQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRS 217
+ +GG +++ N LHLA +V+ L+ G+S + + G TA H+A
Sbjct: 50 YLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 109
Query: 218 PTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADID-------- 269
++ L+ A ++ A++ +G T L++A + V+ LLE GA+
Sbjct: 110 AEVVKVLVKEGA----NINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 165
Query: 270 --AVDIKSG-----------------RSPLIH-AVENNSLSMVQLLLQ--HGANVNAQMY 307
AV ++ G R P +H A + LLLQ H A+V ++M
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 225
Query: 308 ------SGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
SG + LH A+ G + + L+ GA + TPL VA R
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Score = 51.6 bits (122), Expect = 1e-06
Identities = 31/98 (31%), Positives = 58/98 (59%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L+ G DI+ + ++G + L A + + +VQ LL G++V++ G++ALH AS G
Sbjct: 51 LKGGIDINTCN-QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 109
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+V+ LV+ GA+ + ++ + TPL +A ID+++
Sbjct: 110 AEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Score = 29.3 bits (64), Expect = 7.7
Identities = 22/76 (28%), Positives = 29/76 (38%), Gaps = 4/76 (5%)
Query: 356 DILRGKATRPASTSQPDPSPDRSANTSP----ESSSRLSSNGLLSASPSSSPSQSPPRDP 411
D+ + RP + P +R A SP E S LSS+ P SPS +
Sbjct: 1796 DVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHS 1855
Query: 412 PGFPMAPPNFFLPSPS 427
P P A P+ S
Sbjct: 1856 PVSPSAKTERHSPASS 1871
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 101 bits (251), Expect = 2e-21
Identities = 71/219 (32%), Positives = 114/219 (52%), Gaps = 11/219 (5%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D + TPLH A G+ + L+ G ++ ++ TPLH AV + V++L
Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLI----LSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVN 251
+ A A D++ QT H+A +++ C AL+ P ++ + G TALH A
Sbjct: 94 LKHSADVNARDKNWQTPLHIAAANKAVKCAEALV----PLLSNVNVSDRAGRTALHHAAF 149
Query: 252 TECQETVQLLLERGADIDAVDIKSGRSPLIH-AVENNSLSMVQLLLQHGANVNAQMYSGS 310
+ E V+LLL RGA+I+A D K R+ IH A + +V+LL+ HGA V +
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY 207
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ LH+A+ G++ +V+ L+ G D + N + +TPL VA
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 90.9 bits (224), Expect = 2e-18
Identities = 75/291 (25%), Positives = 127/291 (43%), Gaps = 10/291 (3%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D+ +H A G++ V LV+ G E+ + TPLH A + + SVV+ L
Sbjct: 170 DKKDRRAIHWAAYMGHIEVVKLLVS----HGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALH-VAV 250
+ G + +G T H+AC + + L+D A + +N G T LH A
Sbjct: 226 LDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI----VNQKNEKGFTPLHFAAA 281
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+T ++LL+ GAD++ + K G++PL + S Q ++Q GA ++ + +G+
Sbjct: 282 STHGALCLELLVGNGADVN-MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQ 370
+ LH A+ G L+ TL+ SGAD++ + H PL +A D R +
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 371 PDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNF 421
PD + + + N LL+ + R P + A N+
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY 451
Score = 87.4 bits (215), Expect = 2e-17
Identities = 59/196 (30%), Positives = 103/196 (52%), Gaps = 5/196 (2%)
Query: 164 ELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRA 223
+++ +N ++TPLH A ++ LL+ +GA A D T H A S ++
Sbjct: 33 DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV 92
Query: 224 LLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHA 283
LL +A D+ AR+ + T LH+A + + + L+ ++++ D ++GR+ L HA
Sbjct: 93 LLKHSA----DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD-RAGRTALHHA 147
Query: 284 VENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHND 343
+ MV+LLL GAN+NA A+H A+ G + +V+ LV GA+ + K+ +
Sbjct: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY 207
Query: 344 TPLMVARSRRVIDILR 359
TPL A S +I +++
Sbjct: 208 TPLHAAASSGMISVVK 223
Score = 84.0 bits (206), Expect = 3e-16
Identities = 66/215 (30%), Positives = 94/215 (43%), Gaps = 14/215 (6%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ L ++ + AD +DG TPLH+ + G ++ Q G
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII----QSG 329
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
+D + TPLH+A ++ L+T+GA HG HLA C R
Sbjct: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
Query: 223 ALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIH 282
LL S D++ + G T LH A E + LLL GAD + D K GRSPL +
Sbjct: 390 KLLSSG----FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD-KFGRSPLHY 444
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSAS 317
A N + + L+ GA+VN G + LH A+
Sbjct: 445 AAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Score = 83.6 bits (205), Expect = 3e-16
Identities = 79/285 (27%), Positives = 125/285 (43%), Gaps = 46/285 (16%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV----ITTLPSV 187
D+ G T LH V G+ V L+ Q G + + ++ +TP+HL+ I L ++
Sbjct: 683 DKWGRTALHRGAVTGHEECVDALL----QHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 188 VRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDS-------------------- 227
++ + A+P D HG TA H AC + TC+ LL+
Sbjct: 739 LQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVIN 798
Query: 228 ----AAPGTLD------LEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGR 277
AA +D + A + G T LH A T+ E +QLLL A +++VD +G+
Sbjct: 799 DNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD-STGK 857
Query: 278 SPLIHAVENNSLSMVQLLLQHG-ANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSS 336
+PL+ A EN + V++L+ A + Q S ++ALH A +G ++ D +
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRN 917
Query: 337 LKNCHN---DTPLMVARSR---RVIDILRGKATRPASTSQPDPSP 375
L N N TPL VA V+ L GK + + +P
Sbjct: 918 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 77.8 bits (190), Expect = 2e-14
Identities = 76/257 (29%), Positives = 110/257 (42%), Gaps = 42/257 (16%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D +G TPL ++V+ G+ V+ L+N G +D + +T LH +T V L
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNK----GANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 192 VTAGASPMALDRHGQTAAHL--ACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVA 249
+ GA + D G+T HL AC H L ALL SAA + + G TALH A
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIG--VLGALLQSAASMDANPATADNHGYTALHWA 763
Query: 250 VNTECQETVQLLLER---------------------------------GADIDAVDIKSG 276
+ V+LLLE+ GA I G
Sbjct: 764 CYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKG 823
Query: 277 RSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRS-GADS 335
R+PL A + + +QLLL H A VN+ +G + L A+ G V LV S A+
Sbjct: 824 RTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAEL 883
Query: 336 SLKNCHNDTPLMVARSR 352
+L++ +T L +A S+
Sbjct: 884 TLQDNSKNTALHLACSK 900
Score = 75.5 bits (184), Expect = 9e-14
Identities = 64/231 (27%), Positives = 109/231 (47%), Gaps = 13/231 (5%)
Query: 120 PLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLA 179
PL +++ ++ RA G T LH A G+ +V L G ++ ++ + +H A
Sbjct: 128 PLLSNVNVSDRA---GRTALHHAAFSGH----GEMVKLLLSRGANINAFDKKDRRAIHWA 180
Query: 180 VITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARN 239
VV+LLV+ GA D+ T H A + ++ LLD +D+ N
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLG----VDMNEPN 236
Query: 240 YDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPL-IHAVENNSLSMVQLLLQH 298
G T LHVA V L++ GA ++ + K G +PL A + ++LL+ +
Sbjct: 237 AYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEK-GFTPLHFAAASTHGALCLELLVGN 295
Query: 299 GANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
GA+VN + G + LH + G +T+++SGA ++ + +TPL +A
Sbjct: 296 GADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIA 346
Score = 74.3 bits (181), Expect = 2e-13
Identities = 63/224 (28%), Positives = 100/224 (44%), Gaps = 8/224 (3%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A+ + +E G TPLH A + + L G ++++ + +TPLH+ +
Sbjct: 263 AIVNQKNEKGFTPLHFAAASTHGALC---LELLVGNGADVNMKSKDGKTPLHMTALHGRF 319
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTA 245
S + ++ +GA D++G T H+A + + L+ S A D R G+
Sbjct: 320 SRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA----DTAKRGIHGMFP 375
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
LH+A + + + LL G DID D GR+ L A +L + LLL GA+ N +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPD-DFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
G S LH A+ + LV SGA + + TPL A
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 43/240 (17%)
Query: 137 TPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGA 196
+PLH+A G+ H+ + + Q +LD+ N+ +TPL LA V +L+ GA
Sbjct: 552 SPLHLAAYHGH----HQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 607
Query: 197 SPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQE 256
S + D + T +H A E
Sbjct: 608 SILVKDYILKR------------------------------------TPIHAAATNGHSE 631
Query: 257 TVQLLLERGADIDAVDIK--SGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
++LL+ +AVDI+ +G++PL+ +V N V LL GANV+A+ G +ALH
Sbjct: 632 CLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALH 691
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPS 374
+ G V L++ GA L++ TP+ ++ + I +L G + A++ +P+
Sbjct: 692 RGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL-GALLQSAASMDANPA 750
Score = 44.3 bits (103), Expect = 2e-04
Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 6/117 (5%)
Query: 117 MEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGREL-DIYNNLRQTP 175
+E +S+ A T D +T LH+A +G+ + L+ L + R L + N QTP
Sbjct: 872 VEMLVSSASAELTLQDNSKNTALHLACSKGHETSA--LLILEKITDRNLINATNAALQTP 929
Query: 176 LHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPT--CLRALLDSAAP 230
LH+A L VV+ L+ GAS +A+D +G T A LAC CL +L + P
Sbjct: 930 LHVAARNGLTMVVQELLGKGASVLAVDENGYTPA-LACAPNKDVADCLALILATMMP 985
Score = 29.6 bits (65), Expect = 5.9
Identities = 20/67 (29%), Positives = 33/67 (49%)
Query: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339
L+ A+ N V+ L+ +VN Q + LH+A+ G ++ L+ SGA + K+
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 340 CHNDTPL 346
TPL
Sbjct: 72 SKWLTPL 78
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 100 bits (249), Expect = 3e-21
Identities = 69/217 (31%), Positives = 117/217 (53%), Gaps = 9/217 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA +GN+ +V L G +++ TPLH A + +L+
Sbjct: 270 QNGITPLHIASRRGNVI----MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A ++G + H+A + C+R LL A +++ D LT LHVA +
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA----EIDDITLDHLTPLHVAAHC 381
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
++LL++GA ++ + +G +PL A + N + +++LLL+ GA+++A SG +
Sbjct: 382 GHHRVAKVLLDKGAKPNSRAL-NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH AS G LP+V+ L++ GA ++ N +TPL +A
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/227 (32%), Positives = 107/227 (47%), Gaps = 9/227 (3%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
A ++G TPLH+AV NL V L L + G +N TPLH+A V R
Sbjct: 598 AGKNGLTPLHVAVHHNNLDIVKLL--LPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 653
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
L+ G S A G T HLA + + LL A G L N GLT LH+
Sbjct: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG----NKSGLTPLHLVA 709
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+L++ G +DA + G +PL A ++ +V+ LLQH A+VNA+ G
Sbjct: 710 QEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
S LH A+ +G +V L+++GA + + TPL +A+ I +
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815
Score = 89.7 bits (221), Expect = 5e-18
Identities = 77/257 (29%), Positives = 116/257 (45%), Gaps = 15/257 (5%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ + C H ++ + T A E G TPLH+A G+LP V L+ Q G
Sbjct: 406 TPLH-IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QRG 460
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
++ N +TPLH+A V + L+ A A + QT H A ++
Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
Query: 223 ALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIH 282
LL++ A L A G T LH+A ETV LLE+ A A K G +PL
Sbjct: 521 LLLENNANPNLATTA----GHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHV 575
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHN 342
A + + + +LLL+ A+ NA +G + LH A L +V+ L+ G +
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 343 DTPLMVARSRRVIDILR 359
TPL +A + +++ R
Sbjct: 636 YTPLHIAAKQNQVEVAR 652
Score = 89.4 bits (220), Expect = 6e-18
Identities = 76/256 (29%), Positives = 118/256 (46%), Gaps = 33/256 (12%)
Query: 131 ADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQGGREL 165
A EDG TPL +A+ QG+ LPA+H R + Q
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232
Query: 166 DIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALL 225
D+ + TPLH+A +V +LL+ GAS ++G T H+A + +R LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292
Query: 226 DSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVE 285
D A +E + D LT LH A ++LL+ GA I A K+G SP+ A +
Sbjct: 293 DRGA----QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA-KTKNGLSPIHMAAQ 347
Query: 286 NNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP 345
+ L V+LLLQ+ A ++ + LH A+ G + + L+ GA + + + TP
Sbjct: 348 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 407
Query: 346 LMVARSR---RVIDIL 358
L +A + RV+++L
Sbjct: 408 LHIACKKNHVRVMELL 423
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/224 (29%), Positives = 105/224 (46%), Gaps = 9/224 (4%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A G + R+ L + + TPLH+AV +V+LL+
Sbjct: 569 GFTPLHVAAKYGKV----RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 624
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
G SP + +G T H+A + R+LL A + G+T LH+A
Sbjct: 625 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN----AESVQGVTPLHLAAQEGH 680
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
E V LLL + A+ + + KSG +PL + + + +L++HG V+A G + LH
Sbjct: 681 AEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 739
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
AS G + LV+ L++ AD + K +PL A + DI+
Sbjct: 740 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 783
Score = 82.8 bits (203), Expect = 6e-16
Identities = 67/235 (28%), Positives = 110/235 (46%), Gaps = 9/235 (3%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G +P+H+A +L V L+ Q E+D TPLH+A V ++L+
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLL----QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA P + +G T H+AC+ + LL + A ++A GLT LHVA
Sbjct: 392 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA----SIDAVTESGLTPLHVASFM 447
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
V+ LL+RGA + ++K +PL A + + LLQ+ A VNA+ +
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 506
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPAS 367
LH A+ G +V+ L+ + A+ +L TPL +A ++ + + AS
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Score = 82.4 bits (202), Expect = 8e-16
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 13/215 (6%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G+T LHIA + G V LVN G ++ + TPL++A VV+ L+
Sbjct: 111 GNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
GA+ G T +A + + L++ G + L A LH+A +
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA--------LHIAARNDD 218
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
T +LL+ + D + K+G +PL A +L++ QLLL GA+VN +G + LH
Sbjct: 219 TRTAAVLLQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
AS RG + +VR L+ GA K TPL A
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 312
Score = 72.4 bits (176), Expect = 8e-13
Identities = 65/238 (27%), Positives = 102/238 (42%), Gaps = 9/238 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLHIA + ++ R++ L + G +D TPLH+A +V+ L+
Sbjct: 403 NGFTPLHIACKKNHV----RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 458
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GASP + +T H+A + LL + A + A+ D T LH A
Sbjct: 459 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNAKAKDDQTPLHCAARIG 514
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
V+LLLE A+ + +G +PL A + V LL+ A+ G + L
Sbjct: 515 HTNMVKLLLENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQP 371
H A+ G + + L+ A + + TPL VA +DI++ R S P
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
+D+ N +GL LH+A + V LL + ++ K G + L A +V
Sbjct: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT-KKGNTALHIAALAGQDEVV 127
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ L+ +GANVNAQ G + L+ A+ L +V+ L+ +GA+ ++ TPL VA
Sbjct: 128 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Score = 36.6 bits (83), Expect = 0.048
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L G DI+ + ++G + L A + + MV LL + G++ALH A+ G
Sbjct: 65 LRNGVDINTCN-QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 123
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+VR LV GA+ + ++ TPL +A +++++
Sbjct: 124 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 161
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 100 bits (249), Expect = 3e-21
Identities = 69/217 (31%), Positives = 117/217 (53%), Gaps = 9/217 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA +GN+ +V L G +++ TPLH A + +L+
Sbjct: 237 QNGITPLHIASRRGNVI----MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A ++G + H+A + C+R LL A +++ D LT LHVA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA----EIDDITLDHLTPLHVAAHC 348
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
++LL++GA ++ + +G +PL A + N + +++LLL+ GA+++A SG +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRAL-NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH AS G LP+V+ L++ GA ++ N +TPL +A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/227 (32%), Positives = 107/227 (47%), Gaps = 9/227 (3%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
A ++G TPLH+AV NL V L L + G +N TPLH+A V R
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLL--LPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
L+ G S A G T HLA + + LL A G L N GLT LH+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG----NKSGLTPLHLVA 676
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+L++ G +DA + G +PL A ++ +V+ LLQH A+VNA+ G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
S LH A+ +G +V L+++GA + + TPL +A+ I +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 89.7 bits (221), Expect = 5e-18
Identities = 77/257 (29%), Positives = 116/257 (45%), Gaps = 15/257 (5%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ + C H ++ + T A E G TPLH+A G+LP V L+ Q G
Sbjct: 373 TPLH-IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QRG 427
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
++ N +TPLH+A V + L+ A A + QT H A ++
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 223 ALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIH 282
LL++ A L A G T LH+A ETV LLE+ A A K G +PL
Sbjct: 488 LLLENNANPNLATTA----GHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHV 542
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHN 342
A + + + +LLL+ A+ NA +G + LH A L +V+ L+ G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 343 DTPLMVARSRRVIDILR 359
TPL +A + +++ R
Sbjct: 603 YTPLHIAAKQNQVEVAR 619
Score = 89.4 bits (220), Expect = 6e-18
Identities = 76/256 (29%), Positives = 118/256 (46%), Gaps = 33/256 (12%)
Query: 131 ADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQGGREL 165
A EDG TPL +A+ QG+ LPA+H R + Q
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 166 DIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALL 225
D+ + TPLH+A +V +LL+ GAS ++G T H+A + +R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 226 DSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVE 285
D A +E + D LT LH A ++LL+ GA I A K+G SP+ A +
Sbjct: 260 DRGA----QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA-KTKNGLSPIHMAAQ 314
Query: 286 NNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP 345
+ L V+LLLQ+ A ++ + LH A+ G + + L+ GA + + + TP
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374
Query: 346 LMVARSR---RVIDIL 358
L +A + RV+++L
Sbjct: 375 LHIACKKNHVRVMELL 390
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/224 (29%), Positives = 105/224 (46%), Gaps = 9/224 (4%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A G + R+ L + + TPLH+AV +V+LL+
Sbjct: 536 GFTPLHVAAKYGKV----RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
G SP + +G T H+A + R+LL A + G+T LH+A
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN----AESVQGVTPLHLAAQEGH 647
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
E V LLL + A+ + + KSG +PL + + + +L++HG V+A G + LH
Sbjct: 648 AEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
AS G + LV+ L++ AD + K +PL A + DI+
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Score = 82.8 bits (203), Expect = 6e-16
Identities = 67/235 (28%), Positives = 110/235 (46%), Gaps = 9/235 (3%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G +P+H+A +L V L+ Q E+D TPLH+A V ++L+
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL----QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA P + +G T H+AC+ + LL + A ++A GLT LHVA
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA----SIDAVTESGLTPLHVASFM 414
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
V+ LL+RGA + ++K +PL A + + LLQ+ A VNA+ +
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPAS 367
LH A+ G +V+ L+ + A+ +L TPL +A ++ + + AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 82.4 bits (202), Expect = 8e-16
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 13/215 (6%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G+T LHIA + G V LVN G ++ + TPL++A VV+ L+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
GA+ G T +A + + L++ G + L A LH+A +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA--------LHIAARNDD 185
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
T +LL+ + D + K+G +PL A +L++ QLLL GA+VN +G + LH
Sbjct: 186 TRTAAVLLQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
AS RG + +VR L+ GA K TPL A
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.4 bits (176), Expect = 8e-13
Identities = 65/238 (27%), Positives = 102/238 (42%), Gaps = 9/238 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLHIA + ++ R++ L + G +D TPLH+A +V+ L+
Sbjct: 370 NGFTPLHIACKKNHV----RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GASP + +T H+A + LL + A + A+ D T LH A
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNAKAKDDQTPLHCAARIG 481
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
V+LLLE A+ + +G +PL A + V LL+ A+ G + L
Sbjct: 482 HTNMVKLLLENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQP 371
H A+ G + + L+ A + + TPL VA +DI++ R S P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
+D+ N +GL LH+A + V LL + ++ K G + L A +V
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT-KKGNTALHIAALAGQDEVV 94
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ L+ +GANVNAQ G + L+ A+ L +V+ L+ +GA+ ++ TPL VA
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 36.6 bits (83), Expect = 0.048
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L G DI+ + ++G + L A + + MV LL + G++ALH A+ G
Sbjct: 32 LRNGVDINTCN-QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+VR LV GA+ + ++ TPL +A +++++
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 100 bits (249), Expect = 3e-21
Identities = 69/217 (31%), Positives = 117/217 (53%), Gaps = 9/217 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA +GN+ +V L G +++ TPLH A + +L+
Sbjct: 237 QNGITPLHIASRRGNVI----MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A ++G + H+A + C+R LL A +++ D LT LHVA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA----EIDDITLDHLTPLHVAAHC 348
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
++LL++GA ++ + +G +PL A + N + +++LLL+ GA+++A SG +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRAL-NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH AS G LP+V+ L++ GA ++ N +TPL +A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/227 (32%), Positives = 107/227 (47%), Gaps = 9/227 (3%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
A ++G TPLH+AV NL V L L + G +N TPLH+A V R
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLL--LPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
L+ G S A G T HLA + + LL A G L N GLT LH+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG----NKSGLTPLHLVA 676
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+L++ G +DA + G +PL A ++ +V+ LLQH A+VNA+ G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
S LH A+ +G +V L+++GA + + TPL +A+ I +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 89.7 bits (221), Expect = 5e-18
Identities = 77/257 (29%), Positives = 116/257 (45%), Gaps = 15/257 (5%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ + C H ++ + T A E G TPLH+A G+LP V L+ Q G
Sbjct: 373 TPLH-IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QRG 427
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
++ N +TPLH+A V + L+ A A + QT H A ++
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 223 ALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIH 282
LL++ A L A G T LH+A ETV LLE+ A A K G +PL
Sbjct: 488 LLLENNANPNLATTA----GHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHV 542
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHN 342
A + + + +LLL+ A+ NA +G + LH A L +V+ L+ G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 343 DTPLMVARSRRVIDILR 359
TPL +A + +++ R
Sbjct: 603 YTPLHIAAKQNQVEVAR 619
Score = 89.4 bits (220), Expect = 6e-18
Identities = 76/256 (29%), Positives = 118/256 (46%), Gaps = 33/256 (12%)
Query: 131 ADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQGGREL 165
A EDG TPL +A+ QG+ LPA+H R + Q
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 166 DIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALL 225
D+ + TPLH+A +V +LL+ GAS ++G T H+A + +R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 226 DSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVE 285
D A +E + D LT LH A ++LL+ GA I A K+G SP+ A +
Sbjct: 260 DRGA----QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA-KTKNGLSPIHMAAQ 314
Query: 286 NNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP 345
+ L V+LLLQ+ A ++ + LH A+ G + + L+ GA + + + TP
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374
Query: 346 LMVARSR---RVIDIL 358
L +A + RV+++L
Sbjct: 375 LHIACKKNHVRVMELL 390
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/224 (29%), Positives = 105/224 (46%), Gaps = 9/224 (4%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A G + R+ L + + TPLH+AV +V+LL+
Sbjct: 536 GFTPLHVAAKYGKV----RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
G SP + +G T H+A + R+LL A + G+T LH+A
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN----AESVQGVTPLHLAAQEGH 647
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
E V LLL + A+ + + KSG +PL + + + +L++HG V+A G + LH
Sbjct: 648 AEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
AS G + LV+ L++ AD + K +PL A + DI+
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Score = 82.8 bits (203), Expect = 6e-16
Identities = 67/235 (28%), Positives = 110/235 (46%), Gaps = 9/235 (3%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G +P+H+A +L V L+ Q E+D TPLH+A V ++L+
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL----QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA P + +G T H+AC+ + LL + A ++A GLT LHVA
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA----SIDAVTESGLTPLHVASFM 414
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
V+ LL+RGA + ++K +PL A + + LLQ+ A VNA+ +
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPAS 367
LH A+ G +V+ L+ + A+ +L TPL +A ++ + + AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 82.4 bits (202), Expect = 8e-16
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 13/215 (6%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G+T LHIA + G V LVN G ++ + TPL++A VV+ L+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
GA+ G T +A + + L++ G + L A LH+A +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA--------LHIAARNDD 185
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
T +LL+ + D + K+G +PL A +L++ QLLL GA+VN +G + LH
Sbjct: 186 TRTAAVLLQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
AS RG + +VR L+ GA K TPL A
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.4 bits (176), Expect = 8e-13
Identities = 65/238 (27%), Positives = 102/238 (42%), Gaps = 9/238 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLHIA + ++ R++ L + G +D TPLH+A +V+ L+
Sbjct: 370 NGFTPLHIACKKNHV----RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GASP + +T H+A + LL + A + A+ D T LH A
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNAKAKDDQTPLHCAARIG 481
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
V+LLLE A+ + +G +PL A + V LL+ A+ G + L
Sbjct: 482 HTNMVKLLLENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQP 371
H A+ G + + L+ A + + TPL VA +DI++ R S P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
+D+ N +GL LH+A + V LL + ++ K G + L A +V
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT-KKGNTALHIAALAGQDEVV 94
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ L+ +GANVNAQ G + L+ A+ L +V+ L+ +GA+ ++ TPL VA
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 36.6 bits (83), Expect = 0.048
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L G DI+ + ++G + L A + + MV LL + G++ALH A+ G
Sbjct: 32 LRNGVDINTCN-QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+VR LV GA+ + ++ TPL +A +++++
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 100 bits (249), Expect = 3e-21
Identities = 69/217 (31%), Positives = 117/217 (53%), Gaps = 9/217 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA +GN+ +V L G +++ TPLH A + +L+
Sbjct: 237 QNGITPLHIASRRGNVI----MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A ++G + H+A + C+R LL A +++ D LT LHVA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA----EIDDITLDHLTPLHVAAHC 348
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
++LL++GA ++ + +G +PL A + N + +++LLL+ GA+++A SG +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRAL-NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH AS G LP+V+ L++ GA ++ N +TPL +A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/227 (32%), Positives = 107/227 (47%), Gaps = 9/227 (3%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
A ++G TPLH+AV NL V L L + G +N TPLH+A V R
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLL--LPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
L+ G S A G T HLA + + LL A G L N GLT LH+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG----NKSGLTPLHLVA 676
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+L++ G +DA + G +PL A ++ +V+ LLQH A+VNA+ G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
S LH A+ +G +V L+++GA + + TPL +A+ I +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 89.7 bits (221), Expect = 5e-18
Identities = 77/257 (29%), Positives = 116/257 (45%), Gaps = 15/257 (5%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ + C H ++ + T A E G TPLH+A G+LP V L+ Q G
Sbjct: 373 TPLH-IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QRG 427
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
++ N +TPLH+A V + L+ A A + QT H A ++
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 223 ALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIH 282
LL++ A L A G T LH+A ETV LLE+ A A K G +PL
Sbjct: 488 LLLENNANPNLATTA----GHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHV 542
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHN 342
A + + + +LLL+ A+ NA +G + LH A L +V+ L+ G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 343 DTPLMVARSRRVIDILR 359
TPL +A + +++ R
Sbjct: 603 YTPLHIAAKQNQVEVAR 619
Score = 89.4 bits (220), Expect = 6e-18
Identities = 76/256 (29%), Positives = 118/256 (46%), Gaps = 33/256 (12%)
Query: 131 ADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQGGREL 165
A EDG TPL +A+ QG+ LPA+H R + Q
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 166 DIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALL 225
D+ + TPLH+A +V +LL+ GAS ++G T H+A + +R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 226 DSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVE 285
D A +E + D LT LH A ++LL+ GA I A K+G SP+ A +
Sbjct: 260 DRGA----QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA-KTKNGLSPIHMAAQ 314
Query: 286 NNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP 345
+ L V+LLLQ+ A ++ + LH A+ G + + L+ GA + + + TP
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374
Query: 346 LMVARSR---RVIDIL 358
L +A + RV+++L
Sbjct: 375 LHIACKKNHVRVMELL 390
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/224 (29%), Positives = 105/224 (46%), Gaps = 9/224 (4%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A G + R+ L + + TPLH+AV +V+LL+
Sbjct: 536 GFTPLHVAAKYGKV----RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
G SP + +G T H+A + R+LL A + G+T LH+A
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN----AESVQGVTPLHLAAQEGH 647
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
E V LLL + A+ + + KSG +PL + + + +L++HG V+A G + LH
Sbjct: 648 AEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
AS G + LV+ L++ AD + K +PL A + DI+
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Score = 82.8 bits (203), Expect = 6e-16
Identities = 67/235 (28%), Positives = 110/235 (46%), Gaps = 9/235 (3%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G +P+H+A +L V L+ Q E+D TPLH+A V ++L+
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL----QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA P + +G T H+AC+ + LL + A ++A GLT LHVA
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA----SIDAVTESGLTPLHVASFM 414
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
V+ LL+RGA + ++K +PL A + + LLQ+ A VNA+ +
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPAS 367
LH A+ G +V+ L+ + A+ +L TPL +A ++ + + AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 82.4 bits (202), Expect = 8e-16
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 13/215 (6%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G+T LHIA + G V LVN G ++ + TPL++A VV+ L+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
GA+ G T +A + + L++ G + L A LH+A +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA--------LHIAARNDD 185
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
T +LL+ + D + K+G +PL A +L++ QLLL GA+VN +G + LH
Sbjct: 186 TRTAAVLLQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
AS RG + +VR L+ GA K TPL A
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.4 bits (176), Expect = 8e-13
Identities = 65/238 (27%), Positives = 102/238 (42%), Gaps = 9/238 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLHIA + ++ R++ L + G +D TPLH+A +V+ L+
Sbjct: 370 NGFTPLHIACKKNHV----RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GASP + +T H+A + LL + A + A+ D T LH A
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNAKAKDDQTPLHCAARIG 481
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
V+LLLE A+ + +G +PL A + V LL+ A+ G + L
Sbjct: 482 HTNMVKLLLENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQP 371
H A+ G + + L+ A + + TPL VA +DI++ R S P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
+D+ N +GL LH+A + V LL + ++ K G + L A +V
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT-KKGNTALHIAALAGQDEVV 94
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ L+ +GANVNAQ G + L+ A+ L +V+ L+ +GA+ ++ TPL VA
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 36.6 bits (83), Expect = 0.048
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L G DI+ + ++G + L A + + MV LL + G++ALH A+ G
Sbjct: 32 LRNGVDINTCN-QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+VR LV GA+ + ++ TPL +A +++++
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 100 bits (249), Expect = 3e-21
Identities = 69/217 (31%), Positives = 117/217 (53%), Gaps = 9/217 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G TPLHIA +GN+ +V L G +++ TPLH A + +L+
Sbjct: 237 QNGITPLHIASRRGNVI----MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A ++G + H+A + C+R LL A +++ D LT LHVA +
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA----EIDDITLDHLTPLHVAAHC 348
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
++LL++GA ++ + +G +PL A + N + +++LLL+ GA+++A SG +
Sbjct: 349 GHHRVAKVLLDKGAKPNSRAL-NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH AS G LP+V+ L++ GA ++ N +TPL +A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/227 (32%), Positives = 107/227 (47%), Gaps = 9/227 (3%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
A ++G TPLH+AV NL V L L + G +N TPLH+A V R
Sbjct: 565 AGKNGLTPLHVAVHHNNLDIVKLL--LPRGGSPHSPAWNGY--TPLHIAAKQNQVEVARS 620
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
L+ G S A G T HLA + + LL A G L N GLT LH+
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG----NKSGLTPLHLVA 676
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+L++ G +DA + G +PL A ++ +V+ LLQH A+VNA+ G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATT-RMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
S LH A+ +G +V L+++GA + + TPL +A+ I +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Score = 89.7 bits (221), Expect = 5e-18
Identities = 77/257 (29%), Positives = 116/257 (45%), Gaps = 15/257 (5%)
Query: 108 TPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQGNLPAVHRLVNLFQQGG 162
TPL+ + C H ++ + T A E G TPLH+A G+LP V L+ Q G
Sbjct: 373 TPLH-IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL----QRG 427
Query: 163 RELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLR 222
++ N +TPLH+A V + L+ A A + QT H A ++
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 223 ALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIH 282
LL++ A L A G T LH+A ETV LLE+ A A K G +PL
Sbjct: 488 LLLENNANPNLATTA----GHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHV 542
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHN 342
A + + + +LLL+ A+ NA +G + LH A L +V+ L+ G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 343 DTPLMVARSRRVIDILR 359
TPL +A + +++ R
Sbjct: 603 YTPLHIAAKQNQVEVAR 619
Score = 89.4 bits (220), Expect = 6e-18
Identities = 76/256 (29%), Positives = 118/256 (46%), Gaps = 33/256 (12%)
Query: 131 ADEDGDTPLHIAVVQGN-----------------LPAVH--------RLVNLFQQGGREL 165
A EDG TPL +A+ QG+ LPA+H R + Q
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 166 DIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALL 225
D+ + TPLH+A +V +LL+ GAS ++G T H+A + +R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 226 DSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVE 285
D A +E + D LT LH A ++LL+ GA I A K+G SP+ A +
Sbjct: 260 DRGA----QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA-KTKNGLSPIHMAAQ 314
Query: 286 NNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP 345
+ L V+LLLQ+ A ++ + LH A+ G + + L+ GA + + + TP
Sbjct: 315 GDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTP 374
Query: 346 LMVARSR---RVIDIL 358
L +A + RV+++L
Sbjct: 375 LHIACKKNHVRVMELL 390
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/224 (29%), Positives = 105/224 (46%), Gaps = 9/224 (4%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A G + R+ L + + TPLH+AV +V+LL+
Sbjct: 536 GFTPLHVAAKYGKV----RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
G SP + +G T H+A + R+LL A + G+T LH+A
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN----AESVQGVTPLHLAAQEGH 647
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
E V LLL + A+ + + KSG +PL + + + +L++HG V+A G + LH
Sbjct: 648 AEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH 706
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
AS G + LV+ L++ AD + K +PL A + DI+
Sbjct: 707 VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Score = 82.8 bits (203), Expect = 6e-16
Identities = 67/235 (28%), Positives = 110/235 (46%), Gaps = 9/235 (3%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
++G +P+H+A +L V L+ Q E+D TPLH+A V ++L+
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLL----QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA P + +G T H+AC+ + LL + A ++A GLT LHVA
Sbjct: 359 DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA----SIDAVTESGLTPLHVASFM 414
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
V+ LL+RGA + ++K +PL A + + LLQ+ A VNA+ +
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPAS 367
LH A+ G +V+ L+ + A+ +L TPL +A ++ + + AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Score = 82.4 bits (202), Expect = 8e-16
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 13/215 (6%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G+T LHIA + G V LVN G ++ + TPL++A VV+ L+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
GA+ G T +A + + L++ G + L A LH+A +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA--------LHIAARNDD 185
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
T +LL+ + D + K+G +PL A +L++ QLLL GA+VN +G + LH
Sbjct: 186 TRTAAVLLQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
AS RG + +VR L+ GA K TPL A
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.4 bits (176), Expect = 8e-13
Identities = 65/238 (27%), Positives = 102/238 (42%), Gaps = 9/238 (3%)
Query: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVT 193
+G TPLHIA + ++ R++ L + G +D TPLH+A +V+ L+
Sbjct: 370 NGFTPLHIACKKNHV----RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 194 AGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTE 253
GASP + +T H+A + LL + A + A+ D T LH A
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK----VNAKAKDDQTPLHCAARIG 481
Query: 254 CQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSAL 313
V+LLLE A+ + +G +PL A + V LL+ A+ G + L
Sbjct: 482 HTNMVKLLLENNANPNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540
Query: 314 HSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQP 371
H A+ G + + L+ A + + TPL VA +DI++ R S P
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 1/117 (0%)
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
+D+ N +GL LH+A + V LL + ++ K G + L A +V
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT-KKGNTALHIAALAGQDEVV 94
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ L+ +GANVNAQ G + L+ A+ L +V+ L+ +GA+ ++ TPL VA
Sbjct: 95 RELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 36.6 bits (83), Expect = 0.048
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 1/98 (1%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
L G DI+ + ++G + L A + + MV LL + G++ALH A+ G
Sbjct: 32 LRNGVDINTCN-QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQ 90
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR 359
+VR LV GA+ + ++ TPL +A +++++
Sbjct: 91 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 100 bits (249), Expect = 3e-21
Identities = 86/306 (28%), Positives = 140/306 (45%), Gaps = 24/306 (7%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A +G+LP V L+ + G +LD+ ++ QT LH A + ++ L+
Sbjct: 42 GRTPLHLAANKGHLPVVQILL----KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHE 97
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTEC 254
G + D+ G TA H A H + L+ + A ++ A+N G TALH+A
Sbjct: 98 GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA----NVLAKNKAGNTALHLACQNSH 153
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
++ ++LL G+ D + +G + L A N LS+++LLL +V+ + +G +ALH
Sbjct: 154 SQSTRVLLLAGSRADLKN-NAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALH 212
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR----------RVIDILRGKATR 364
A+ + + L+ +GAD+++ N TPL AR + +LR R
Sbjct: 213 VAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGR 272
Query: 365 PASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLP 424
+ +R A + P S G +SA + S Q+ R A F
Sbjct: 273 SLRKKRERLKEERRAQSVPRDEV-AQSKGSVSAGDTPSSEQAVARKEE----AREEFLSA 327
Query: 425 SPSPPA 430
SP P A
Sbjct: 328 SPEPRA 333
Score = 69.7 bits (169), Expect = 5e-12
Identities = 59/212 (27%), Positives = 99/212 (46%), Gaps = 6/212 (2%)
Query: 191 LVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAV 250
L+ GA +A+ +HG+T HLA ++ LL + DL+ ++ TALH A
Sbjct: 29 LINKGAR-VAVTKHGRTPLHLAANKGHLPVVQILLKAGC----DLDVQDDGDQTALHRAT 83
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
E + L+ G +D D K G + L A + +LL++ GANV A+ +G+
Sbjct: 84 VVGNTEIIAALIHEGCALDRQD-KDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGN 142
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQ 370
+ALH A R L+ +G+ + LKN DT L VA + I+R T S +
Sbjct: 143 TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHE 202
Query: 371 PDPSPDRSANTSPESSSRLSSNGLLSASPSSS 402
+ + D + + + + + + LL A ++
Sbjct: 203 KNQAGDTALHVAAALNHKKVAKILLEAGADTT 234
Score = 63.9 bits (154), Expect = 3e-10
Identities = 51/166 (30%), Positives = 79/166 (47%), Gaps = 9/166 (5%)
Query: 130 RADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVR 189
R D+DG+T LH A G + LV + G + N T LHLA + R
Sbjct: 103 RQDKDGNTALHEASWHGFSQSAKLLV----KAGANVLAKNKAGNTALHLACQNSHSQSTR 158
Query: 190 LLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVA 249
+L+ AG+ + G T H+A + + +R LL + + +N G TALHVA
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFC----SVHEKNQAGDTALHVA 214
Query: 250 VNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLL 295
++ ++LLE GAD V+ +G++PL A +N+ + LL
Sbjct: 215 AALNHKKVAKILLEAGADTTIVN-NAGQTPLETARYHNNPEVALLL 259
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 99.0 bits (245), Expect = 8e-21
Identities = 75/263 (28%), Positives = 123/263 (46%), Gaps = 17/263 (6%)
Query: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
++ +L + G +++ +T HLA +R+++T G A D G +A HLA
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
++ C+R LL S P E+ + G TALH A C + VQ+L E + I+ D
Sbjct: 94 AKNSHHECIRKLLQSKCPA----ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
+ G PL+ AV+N + LL HGA+VN++ SG +AL A G V L++ G
Sbjct: 150 L-DGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 333 ADSSLKNCHNDTPL---MVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRL 389
AD +L + L ++ + + +L K ++ A P T P+ S +
Sbjct: 209 ADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP---------TKPKQLSDV 259
Query: 390 SSNGLLSASPSSSPSQSPPRDPP 412
SS ++++P S +PP
Sbjct: 260 SSPRSITSTPLSGKESVFFAEPP 282
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
L N + ++ LL ++GA D G++ A + +++++ HG +V AQ
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHD-SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+G SALH A+ +R L++S + + T L A ++
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/262 (29%), Positives = 120/262 (45%), Gaps = 16/262 (6%)
Query: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
++ +L + G +++ +T HLA +R+++T G A D G +A HLA
Sbjct: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 96
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
++ C+R LL S P E+ + G TALH A C + VQ+L E + I+ D
Sbjct: 97 AKNSHHECIRKLLQSKCPA----ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 152
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
+ G PL+ AV+N + LL HGA+VN++ SG +AL A G V L++ G
Sbjct: 153 L-DGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 211
Query: 333 ADSSLKNCHNDTPL---MVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRL 389
AD +L + L ++ + + +L K ++ A P P + S SS R
Sbjct: 212 ADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP-TKPKQHDQVSKISSER- 269
Query: 390 SSNGLLSASPSSSPSQSPPRDP 411
S +P + PP P
Sbjct: 270 ------SGTPKKRKAPPPPISP 285
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
L N + ++ LL ++GA D G++ A + +++++ HG +V AQ
Sbjct: 27 LQAVENGDAEKVASLLGKKGASATKHD-SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 85
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+G SALH A+ +R L++S + + T L A ++
Sbjct: 86 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 132
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/262 (29%), Positives = 120/262 (45%), Gaps = 16/262 (6%)
Query: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
++ +L + G +++ +T HLA +R+++T G A D G +A HLA
Sbjct: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 85
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
++ C+R LL S P E+ + G TALH A C + VQ+L E + I+ D
Sbjct: 86 AKNSHHECIRKLLQSKCPA----ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 141
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
+ G PL+ AV+N + LL HGA+VN++ SG +AL A G V L++ G
Sbjct: 142 L-DGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 200
Query: 333 ADSSLKNCHNDTPL---MVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRL 389
AD +L + L ++ + + +L K ++ A P P + S SS R
Sbjct: 201 ADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP-TKPKQHDQVSKISSER- 258
Query: 390 SSNGLLSASPSSSPSQSPPRDP 411
S +P + PP P
Sbjct: 259 ------SGTPKKRKAPPPPISP 274
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
L N + ++ LL ++GA D G++ A + +++++ HG +V AQ
Sbjct: 16 LQAVENGDAEKVASLLGKKGASATKHD-SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 74
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+G SALH A+ +R L++S + + T L A ++
Sbjct: 75 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/262 (29%), Positives = 120/262 (45%), Gaps = 16/262 (6%)
Query: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
++ +L + G +++ +T HLA +R+++T G A D G +A HLA
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
++ C+R LL S P E+ + G TALH A C + VQ+L E + I+ D
Sbjct: 94 AKNSHHECIRKLLQSKCPA----ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
+ G PL+ AV+N + LL HGA+VN++ SG +AL A G V L++ G
Sbjct: 150 L-DGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 333 ADSSLKNCHNDTPL---MVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRL 389
AD +L + L ++ + + +L K ++ A P P + S SS R
Sbjct: 209 ADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP-TKPKQHDQVSKISSER- 266
Query: 390 SSNGLLSASPSSSPSQSPPRDP 411
S +P + PP P
Sbjct: 267 ------SGTPKKRKAPPPPISP 282
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
L N + ++ LL ++GA D G++ A + +++++ HG +V AQ
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHD-SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+G SALH A+ +R L++S + + T L A ++
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/262 (29%), Positives = 120/262 (45%), Gaps = 16/262 (6%)
Query: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
++ +L + G +++ +T HLA +R+++T G A D G +A HLA
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
++ C+R LL S P E+ + G TALH A C + VQ+L E + I+ D
Sbjct: 94 AKNSHHECIRKLLQSKCPA----ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
+ G PL+ AV+N + LL HGA+VN++ SG +AL A G V L++ G
Sbjct: 150 L-DGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 333 ADSSLKNCHNDTPL---MVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRL 389
AD +L + L ++ + + +L K ++ A P P + S SS R
Sbjct: 209 ADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP-TKPKQHDQVSKISSER- 266
Query: 390 SSNGLLSASPSSSPSQSPPRDP 411
S +P + PP P
Sbjct: 267 ------SGTPKKRKAPPPPISP 282
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
L N + ++ LL ++GA D G++ A + +++++ HG +V AQ
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHD-SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+G SALH A+ +R L++S + + T L A ++
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/262 (29%), Positives = 120/262 (45%), Gaps = 16/262 (6%)
Query: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
++ +L + G +++ +T HLA +R+++T G A D G +A HLA
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
Query: 213 CEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVD 272
++ C+R LL S P E+ + G TALH A C + VQ+L E + I+ D
Sbjct: 94 AKNSHHECIRKLLQSKCPA----ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
Query: 273 IKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG 332
+ G PL+ AV+N + LL HGA+VN++ SG +AL A G V L++ G
Sbjct: 150 L-DGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 333 ADSSLKNCHNDTPL---MVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRL 389
AD +L + L ++ + + +L K ++ A P P + S SS R
Sbjct: 209 ADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP-TKPKQHDQVSKISSER- 266
Query: 390 SSNGLLSASPSSSPSQSPPRDP 411
S +P + PP P
Sbjct: 267 ------SGTPKKRKAPPPPISP 282
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
L N + ++ LL ++GA D G++ A + +++++ HG +V AQ
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHD-SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+G SALH A+ +R L++S + + T L A ++
Sbjct: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 97.8 bits (242), Expect = 2e-20
Identities = 67/218 (30%), Positives = 107/218 (49%), Gaps = 9/218 (4%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D + TPLH+A G+ + L+ G ++ +N+ TPLH AV + V++L
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLI----LSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVN 251
+ A A D++ QT H+A +++ C ++ P + + G TALH A
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAANKAVKCAEVII----PLLSSVNVSDRGGRTALHHAAL 124
Query: 252 TECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSS 311
E V LLL +GA+I+A D K R L A L +V LL+ HGA V + G +
Sbjct: 125 NGHVEMVNLLLAKGANINAFD-KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183
Query: 312 ALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
LH+A+ G + +V+ L+ G + N + +T L +A
Sbjct: 184 PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Score = 90.9 bits (224), Expect = 2e-18
Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 5/196 (2%)
Query: 164 ELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRA 223
+++ ++ ++TPLH+A ++ LL+ +GA A D T H A RS ++
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 224 LLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHA 283
L+ +A D+ AR+ + T LHVA + + ++++ + ++ D + GR+ L HA
Sbjct: 68 LIKHSA----DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD-RGGRTALHHA 122
Query: 284 VENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHND 343
N + MV LLL GAN+NA ALH A+ G L +V L+ GA+ + K+
Sbjct: 123 ALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGY 182
Query: 344 TPLMVARSRRVIDILR 359
TPL A S I++++
Sbjct: 183 TPLHAAASNGQINVVK 198
Score = 90.1 bits (222), Expect = 4e-18
Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 10/242 (4%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D+ LH A G+L V L+N G E+ + TPLH A +VV+ L
Sbjct: 145 DKKDRRALHWAAYMGHLDVVALLIN----HGAEVTCKDKKGYTPLHAAASNGQINVVKHL 200
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALH-VAV 250
+ G ++ +G TA H+AC + + L+D A ++ N +G T LH A
Sbjct: 201 LNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA----NVNQPNNNGFTPLHFAAA 256
Query: 251 NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGS 310
+T ++LL+ GAD++ + K G+SPL + + Q L+Q+G ++ G+
Sbjct: 257 STHGALCLELLVNNGADVN-IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
Query: 311 SALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQ 370
+ LH A+ G L+ TL SGAD++ H+ PL +A D R +
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDT 375
Query: 371 PD 372
PD
Sbjct: 376 PD 377
Score = 77.0 bits (188), Expect = 3e-14
Identities = 76/281 (27%), Positives = 113/281 (40%), Gaps = 43/281 (15%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A T D+ G TPLH A G + V L+NL G E+D N T LH+A
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNL----GVEIDEINVYGNTALHIACYNGQD 227
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEH-RSPTCLRALLDSAAPGTLDLEARNYDGLT 244
+VV L+ GA+ + +G T H A CL L+++ A D+ ++ DG +
Sbjct: 228 AVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA----DVNIQSKDGKS 283
Query: 245 ALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPL------------------------ 280
LH+ Q L++ G +ID VD K G +PL
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVD-KDGNTPLHVAARYGHELLINTLRTSGADTAK 342
Query: 281 --IH-------AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRS 331
IH A N + LL G ++ G + LH+A+ G + ++ L S
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
Query: 332 GADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPD 372
GAD K+ TPL A + + T A+ ++ D
Sbjct: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Score = 75.1 bits (183), Expect = 1e-13
Identities = 64/223 (28%), Positives = 98/223 (43%), Gaps = 7/223 (3%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D++G +H A G+ + L+ G E D + ++PLHLA + +L
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD--SGATKSPLHLAAYNGHHQALEVL 561
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVN 251
+ + D G+TA LA C+ AL++ PG N T LH +V
Sbjct: 562 LQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN---PGASIFVKDNVTKRTPLHASVI 618
Query: 252 TECQETVQLLLERGADIDAVDIKS--GRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSG 309
++LLLE + +AVD+K G++PL+ AV + V LLL+ ANV+ G
Sbjct: 619 NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG 678
Query: 310 SSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
+ALH G V+ L+ K+ TPL A +R
Sbjct: 679 CTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
Score = 72.0 bits (175), Expect = 1e-12
Identities = 84/310 (27%), Positives = 132/310 (42%), Gaps = 47/310 (15%)
Query: 80 EALYYPGALLPLYPTRAMGSPF--PLVNLPTPLYPMMCPM-EHPLSADIAMATRADEDGD 136
EAL PGA + + +P ++N T ++ + ++P + D+ D G
Sbjct: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK-----DAKGQ 646
Query: 137 TPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGA 196
TPL +AV G++ AV +L + +D + L T LH ++T V++L+
Sbjct: 647 TPLMLAVAYGHIDAV----SLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702
Query: 197 SPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQE 256
S + D G+T H A T L LL A D ++ G T LH A +
Sbjct: 703 SILCKDSRGRTPLHYAAARGHATWLSELLQMAL-SEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 257 TVQLLLER--------------------------GADIDAVDIK-------SGRSPLIHA 283
+++LLE+ + A+D GR+PL A
Sbjct: 762 CIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA 821
Query: 284 VENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSG-ADSSLKNCHN 342
+ + +QLLL+H A VNA SG +AL A+ G V LV S AD ++K+
Sbjct: 822 AFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 881
Query: 343 DTPLMVARSR 352
+TPL +A S+
Sbjct: 882 NTPLHLACSK 891
Score = 67.4 bits (163), Expect = 3e-11
Identities = 65/245 (26%), Positives = 102/245 (41%), Gaps = 38/245 (15%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
D+ G T LH A GN+ + L Q G + + +TPLH A + L
Sbjct: 377 DKFGRTCLHAAAAGGNVECI----KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 192 VTAGASPMALDRHGQTAAHLAC----------------------------EHRSPTCLRA 223
VT GA+ D G+TA H A E + CL
Sbjct: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEF 492
Query: 224 LLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLER-GADIDAVDIKSGRSPLIH 282
LL + A ++ R+ +G ++H A ++ ++LLLER + + D + +SPL
Sbjct: 493 LLQNDANPSI----RDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHL 548
Query: 283 AVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLK-NCH 341
A N +++LLQ +++ + G +AL A+ +G V L+ GA +K N
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 342 NDTPL 346
TPL
Sbjct: 609 KRTPL 613
Score = 33.1 bits (74), Expect = 0.53
Identities = 27/117 (23%), Positives = 49/117 (41%), Gaps = 5/117 (4%)
Query: 124 DIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITT 183
D ++ + D+ G TPL A ++ + L+ + ++ +N +T L +A
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLL----RHSAPVNAVDNSGKTALMMAAENG 858
Query: 184 LPSVVRLLVTAGASPMAL-DRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARN 239
V +LV + + + + D+ T HLAC C +LD +L E N
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 94.0 bits (232), Expect = 3e-19
Identities = 83/282 (29%), Positives = 129/282 (45%), Gaps = 38/282 (13%)
Query: 108 TPLYPMMCPMEHPLSA------DIAMATRADEDGDTPLHIAVVQGN-------------- 147
TPLY M E+ L + A + A EDG TPL +A+ QG+
Sbjct: 142 TPLY--MAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKG 199
Query: 148 ---LPAVH--------RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGA 196
LPA+H + L Q D+ + TPLH+A +V LL+ A
Sbjct: 200 KVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA 259
Query: 197 SPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQE 256
+ R+ T H+A + + ++ LLD A ++A+ DGLT LH + ++
Sbjct: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGA----KIDAKTRDGLTPLHCGARSGHEQ 315
Query: 257 TVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSA 316
V++LL+R A I K+G SPL A + + L+ VQLLLQH V+ +ALH A
Sbjct: 316 VVEMLLDRAAPI-LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVA 374
Query: 317 SGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDIL 358
+ G + + L+ A+ + K + TPL +A + I ++
Sbjct: 375 AHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Score = 92.4 bits (228), Expect = 7e-19
Identities = 66/216 (30%), Positives = 112/216 (51%), Gaps = 10/216 (4%)
Query: 137 TPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGA 196
TPLH+A +GN +V L G ++D TPLH + VV +L+ A
Sbjct: 270 TPLHVASKRGNA----NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Query: 197 SPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQE 256
++ ++G + H+A + C++ LL P ++ D LTALHVA + +
Sbjct: 326 PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP----VDDVTNDYLTALHVAAHCGHYK 381
Query: 257 TVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSA 316
++LL++ A+ +A + +G +PL A + N + +++LLL+HGA++ A SG + +H A
Sbjct: 382 VAKVLLDKKANPNAKAL-NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 317 SGRGLLPLVRTLVRSGADSSLKNCHNDTPL-MVARS 351
+ G + +V L+ GA + N +T L M ARS
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 476
Score = 92.4 bits (228), Expect = 7e-19
Identities = 71/253 (28%), Positives = 111/253 (43%), Gaps = 34/253 (13%)
Query: 135 GDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTA 194
G TPLH+A G L + NL Q D TPLH+A V LL+
Sbjct: 565 GFTPLHVAAKYGKL----EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 195 GASPMALDRHGQTAAHLACEHRSPTCLRALLD------------------SAAPGTLDLE 236
GASP A ++G T H+A + LL+ +A G +D+
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 237 A-----------RNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVE 285
+ N GLT LH+A + ++L+ +GA +DA K G +PL
Sbjct: 681 SLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA-QTKMGYTPLHVGCH 739
Query: 286 NNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTP 345
++ +V LLQH A VNA+ +G + LH A+ +G ++ L+++ A + + +T
Sbjct: 740 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
Query: 346 LMVARSRRVIDIL 358
L +AR I ++
Sbjct: 800 LGIARRLGYISVV 812
Score = 92.0 bits (227), Expect = 1e-18
Identities = 73/238 (30%), Positives = 112/238 (47%), Gaps = 11/238 (4%)
Query: 121 LSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV 180
L D A +D TPLHI+ G V +L+ Q G + TPLHL+
Sbjct: 485 LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL----QQGASPNAATTSGYTPLHLSA 540
Query: 181 ITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLD-SAAPGTLDLEARN 239
V L+ GAS + G T H+A ++ LL SA+P +A
Sbjct: 541 REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP-----DAAG 595
Query: 240 YDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHG 299
GLT LHVA + + Q+ LLL++GA A K+G +PL A + N + + LL++G
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGASPHAA-AKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 300 ANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
A+ NA G +++H A+ G + +V L+ A+ +L N TPL +A +++
Sbjct: 655 ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNV 712
Score = 79.3 bits (194), Expect = 6e-15
Identities = 64/225 (28%), Positives = 101/225 (44%), Gaps = 9/225 (4%)
Query: 133 EDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
E G TP+H+A G++ V +L++ G + N +T LH+A + VVR LV
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMH----HGASPNTTNVRGETALHMAARSGQAEVVRYLV 486
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA A + QT H++ ++ LL A A G T LH++
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN----AATTSGYTPLHLSARE 542
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
++ LL+ GA + ++ K G +PL A + L + LLLQ A+ +A SG +
Sbjct: 543 GHEDVAAFLLDHGASL-SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTP 601
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDI 357
LH A+ + L+ GA + TPL +A + +DI
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDI 646
Score = 77.0 bits (188), Expect = 3e-14
Identities = 79/275 (28%), Positives = 123/275 (44%), Gaps = 39/275 (14%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLL 191
+++G LH+A +G++ V L+ Q +D T LH+A + VV++L
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELL----QREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 192 VTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVN 251
VT GA+ A ++G T ++A + ++ LLD+ A +L E DG T L VA+
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATE----DGFTPLAVALQ 182
Query: 252 TECQETVQLLLE----------------RGADIDA------------VDIKSGRSPLIHA 283
+ V LLLE R D A V+ KSG +PL A
Sbjct: 183 QGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Query: 284 VENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHND 343
++++ LLL A V+ + + LH AS RG +V+ L+ GA K
Sbjct: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL 302
Query: 344 TPLMV-ARS--RRVIDILRGKATRPASTSQPDPSP 375
TPL ARS +V+++L +A S ++ SP
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSP 337
Score = 75.9 bits (185), Expect = 7e-14
Identities = 64/206 (31%), Positives = 96/206 (46%), Gaps = 10/206 (4%)
Query: 174 TPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLD-SAAPGT 232
TPLH+A V+ LL+ GAS A+ G T H+A + L+ A+P T
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
N G TALH+A + E V+ L++ GA ++A K ++PL + +V
Sbjct: 462 T-----NVRGETALHMAARSGQAEVVRYLVQDGAQVEA-KAKDDQTPLHISARLGKADIV 515
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVAR-- 350
Q LLQ GA+ NA SG + LH ++ G + L+ GA S+ TPL VA
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575
Query: 351 -SRRVIDILRGKATRPASTSQPDPSP 375
V ++L K+ P + + +P
Sbjct: 576 GKLEVANLLLQKSASPDAAGKSGLTP 601
Score = 67.8 bits (164), Expect = 2e-11
Identities = 50/142 (35%), Positives = 76/142 (53%), Gaps = 9/142 (6%)
Query: 233 LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMV 292
+D+ N +GL ALH+A E V LL+R A++DA K G + L A +V
Sbjct: 65 VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAAT-KKGNTALHIASLAGQAEVV 123
Query: 293 QLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR 352
++L+ +GANVNAQ +G + L+ A+ L +V+ L+ +GA SL TPL VA +
Sbjct: 124 KVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQ 183
Query: 353 ---RVIDIL-----RGKATRPA 366
+V+ +L +GK PA
Sbjct: 184 GHDQVVSLLLENDTKGKVRLPA 205
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/219 (24%), Positives = 102/219 (46%), Gaps = 12/219 (5%)
Query: 160 QGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPT 219
+ G +++I N LHLA VV L+ A+ A + G TA H+A
Sbjct: 62 KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE 121
Query: 220 CLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSP 279
++ L+ + A ++ A++ +G T L++A E V+ LL+ GA ++ + G +P
Sbjct: 122 VVKVLVTNGA----NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTP 176
Query: 280 LIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKN 339
L A++ +V LLL++ ++ ALH A+ + L+++ ++ +++
Sbjct: 177 LAVALQQGHDQVVSLLLENDTKGKVRL----PALHIAARKDDTKAAALLLQNDNNADVES 232
Query: 340 CHNDTPLMVAR---SRRVIDILRGKATRPASTSQPDPSP 375
TPL +A + V +L +A T++ D +P
Sbjct: 233 KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITP 271
Score = 50.1 bits (118), Expect = 4e-06
Identities = 33/108 (30%), Positives = 60/108 (55%), Gaps = 1/108 (0%)
Query: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGL 321
++ G DI+ + ++G + L A + + +V LLQ ANV+A G++ALH AS G
Sbjct: 61 IKNGVDINICN-QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
Query: 322 LPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTS 369
+V+ LV +GA+ + ++ + TPL +A +++++ AS S
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 93.6 bits (231), Expect = 3e-19
Identities = 69/223 (30%), Positives = 111/223 (49%), Gaps = 9/223 (4%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A D+DG TPL +A +G++ +V+L +GG ++D +N +TPL A
Sbjct: 739 AEVDHCDKDGMTPLLVAAYEGHVD----VVDLLLEGGADVDHTDNNGRTPLLAAASMGHA 794
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTA 245
SVV L+ GA+ ++D G+T +A + +R LLD LD R+ G T
Sbjct: 795 SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG----LDENHRDDAGWTP 850
Query: 246 LHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQ 305
LH+A + + L+E+GA + +D GR P I A + VQ+LL++ +N++ +
Sbjct: 851 LHMAAFEGHRLICEALIEQGARTNEID-NDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 306 MYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMV 348
Y G +AL A+ G +V L GAD + K+ L +
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYI 952
Score = 87.4 bits (215), Expect = 2e-17
Identities = 89/335 (26%), Positives = 140/335 (41%), Gaps = 48/335 (14%)
Query: 132 DEDGDTPLHIAVVQGNLPAVHRLV--NLFQQGGRELDIYNNLR----------------- 172
D+ G TPLH+A +G HRL+ L +QG R +I N+ R
Sbjct: 844 DDAGWTPLHMAAFEG-----HRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898
Query: 173 ---------------QTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRS 217
+ L +A + +V LL + GA D G+ ++
Sbjct: 899 LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 218 PTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGR 277
T L++ A ++EA + +G TALHV+ E VQ+L+ AD++A D + R
Sbjct: 959 LTMAEYFLENGA----NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK-R 1013
Query: 278 SPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSL 337
S L A + +VQLL++HGA V+ G++AL A+ G + +V+ L+ GAD +
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
Query: 338 KNCHNDTPLMVARSR---RVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGL 394
+ T + VA ++I +L + P P SS++ S +
Sbjct: 1074 ADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTI 1133
Query: 395 LSASPSSSPSQSPPRDPPGFPMAPPN-FFLPSPSP 428
S S S+ G P P + F PS SP
Sbjct: 1134 KSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESP 1168
Score = 75.9 bits (185), Expect = 7e-14
Identities = 75/226 (33%), Positives = 108/226 (47%), Gaps = 18/226 (7%)
Query: 131 ADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRL 190
AD D T L A G+ V +NL Q G E++ +N +T L A +V
Sbjct: 640 ADADSRTALRAAAWGGHEDIV---LNLLQHGA-EVNKADNEGRTALIAAAYMGHREIVEH 695
Query: 191 LVTAGASPMALDRHGQTAAHLAC-------EHRSPTCLRALLDSAAPGTLDLEARNYDGL 243
L+ GA D G+TA +A H S L L+D A +++ + DG+
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL--LIDRGA----EVDHCDKDGM 749
Query: 244 TALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVN 303
T L VA + V LLLE GAD+D D +GR+PL+ A S+V LL GA V+
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTD-NNGRTPLLAAASMGHASVVNTLLFWGAAVD 808
Query: 304 AQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ G + L AS +G + +VRTL+ G D + ++ TPL +A
Sbjct: 809 SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMA 854
Score = 74.3 bits (181), Expect = 2e-13
Identities = 76/307 (24%), Positives = 133/307 (43%), Gaps = 41/307 (13%)
Query: 134 DGDTPLHIAVVQGNLPAVHR-LVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLV 192
DG L +A ++G HR +V L G +++ + + L++ + ++ +
Sbjct: 912 DGRNALRVAALEG-----HRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966
Query: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNT 252
GA+ A D G+TA H++C ++ L+ A D+ A + + +AL A
Sbjct: 967 ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA----DVNAADNEKRSALQSAAWQ 1022
Query: 253 ECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSA 312
+ VQLL+E GA +D G + L A + + +VQ+LL+HGA+ N G +A
Sbjct: 1023 GHVKVVQLLIEHGAVVDHT-CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081
Query: 313 LHSASGRGLLPLVRTLVRSGADSSLKNCH-------NDTPLMVARSR------------- 352
+ A+ G +++ L + GA SSL C PL S+
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGA-SSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGS 1140
Query: 353 ----RVIDILRGKATRP-----ASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSP 403
+ LRG P + + PD + DR ++ +S + S N L + S++
Sbjct: 1141 TGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTAT 1200
Query: 404 SQSPPRD 410
+Q+ P D
Sbjct: 1201 AQTVPID 1207
Score = 72.4 bits (176), Expect = 8e-13
Identities = 75/291 (25%), Positives = 123/291 (42%), Gaps = 14/291 (4%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLP 185
A D+DG T L A G+ V L+ G ++D + +T L A
Sbjct: 602 ANINHTDQDGWTALRSAAWGGHTEVVSALL----YAGVKVDCADADSRTALRAAAWGGHE 657
Query: 186 SVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTA 245
+V L+ GA D G+TA A + LLD A ++ + DG TA
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA----EVNHEDVDGRTA 713
Query: 246 LHVAV-----NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGA 300
L VA + V LL++RGA++D D K G +PL+ A + +V LLL+ GA
Sbjct: 714 LSVAALCVPASKGHASVVSLLIDRGAEVDHCD-KDGMTPLLVAAYEGHVDVVDLLLEGGA 772
Query: 301 NVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRG 360
+V+ +G + L +A+ G +V TL+ GA + T L +A ++ ++++R
Sbjct: 773 DVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Query: 361 KATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDP 411
R + D + + + RL L+ ++ + R P
Sbjct: 833 LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883
Score = 62.4 bits (150), Expect = 8e-10
Identities = 58/203 (28%), Positives = 91/203 (44%), Gaps = 10/203 (4%)
Query: 150 AVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPS---VVRLLVTAGASPMALDRHGQ 206
A+H + + Q EL ++ TP+ ++ T +P V++LLV AGA + D
Sbjct: 456 ALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTS 515
Query: 207 TAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGA 266
A E +R LLD+ A + + +G T L A + + V LL+ RGA
Sbjct: 516 CIVRQALEREDS--IRTLLDNGA----SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGA 569
Query: 267 DIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVR 326
D++ D G +PL A +V L+ GAN+N G +AL SA+ G +V
Sbjct: 570 DLEIEDAH-GHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVS 628
Query: 327 TLVRSGADSSLKNCHNDTPLMVA 349
L+ +G + + T L A
Sbjct: 629 ALLYAGVKVDCADADSRTALRAA 651
Score = 58.2 bits (139), Expect = 2e-08
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 6/225 (2%)
Query: 126 AMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRE-LDIYNNLRQTPLHLAVITTL 184
A +AD +G T L A G+ V L++ + E +D L L +
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 185 PSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLT 244
SVV LL+ GA D+ G T +A + LL+ A D++ + +G T
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA----DVDHTDNNGRT 783
Query: 245 ALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNA 304
L A + V LL GA +D++D GR+ L A ++ +V+ LL G + N
Sbjct: 784 PLLAAASMGHASVVNTLLFWGAAVDSID-SEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 305 QMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVA 349
+ +G + LH A+ G + L+ GA ++ + P ++A
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/128 (31%), Positives = 68/128 (53%), Gaps = 6/128 (4%)
Query: 255 QETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALH 314
QE +QLL++ GA +++ D ++ + A+E ++ LL +GA+VN +G + L
Sbjct: 494 QEVLQLLVKAGAHVNSEDDRTS-CIVRQALERED--SIRTLLDNGASVNQCDSNGRTLLA 550
Query: 315 SASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSR---RVIDILRGKATRPASTSQP 371
+A+ G L +V LV GAD +++ H TPL +A + +V++ L G T Q
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 372 DPSPDRSA 379
+ RSA
Sbjct: 611 GWTALRSA 618
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,649,601
Number of Sequences: 37866
Number of extensions: 1484456
Number of successful extensions: 21628
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 534
Number of HSP's successfully gapped in prelim test: 953
Number of HSP's that attempted gapping in prelim test: 10763
Number of HSP's gapped (non-prelim): 7349
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.