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Search of human proteins with 164419758
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|164419758 bromodomain containing 2 [Homo sapiens]
(801 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|164419758 bromodomain containing 2 [Homo sapiens] 1599 0.0
gi|4826806 bromodomain containing 2 [Homo sapiens] 1599 0.0
gi|11067749 bromodomain containing protein 3 [Homo sapiens] 864 0.0
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ... 731 0.0
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 731 0.0
gi|46399200 testis-specific bromodomain protein [Homo sapiens] 654 0.0
gi|46399198 testis-specific bromodomain protein [Homo sapiens] 654 0.0
gi|119943102 CREB binding protein isoform b [Homo sapiens] 91 3e-18
gi|119943104 CREB binding protein isoform a [Homo sapiens] 91 3e-18
gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens] 84 4e-16
gi|50345997 E1A binding protein p300 [Homo sapiens] 83 9e-16
gi|38788260 bromodomain PHD finger transcription factor isoform ... 78 4e-14
gi|38788274 bromodomain PHD finger transcription factor isoform ... 78 4e-14
gi|32967605 bromodomain adjacent to zinc finger domain, 1A isofo... 74 7e-13
gi|32967603 bromodomain adjacent to zinc finger domain, 1A isofo... 74 7e-13
gi|20357588 TBP-associated factor 1 isoform 2 [Homo sapiens] 73 9e-13
gi|20357585 TBP-associated factor 1 isoform 1 [Homo sapiens] 73 9e-13
gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo... 72 2e-12
gi|148612882 cat eye syndrome chromosome region, candidate 2 [Ho... 72 2e-12
gi|153791535 general control of amino acid synthesis 5-like 2 [H... 71 3e-12
gi|209977097 tripartite motif-containing 66 [Homo sapiens] 70 6e-12
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo... 70 8e-12
gi|74027251 tripartite motif-containing 33 protein isoform beta ... 69 2e-11
gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo... 69 2e-11
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 67 5e-11
gi|34452709 bromodomain containing 8 isoform 3 [Homo sapiens] 67 5e-11
gi|34452707 bromodomain containing 8 isoform 2 [Homo sapiens] 67 5e-11
gi|34452705 bromodomain containing 8 isoform 1 [Homo sapiens] 67 5e-11
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 67 7e-11
gi|47419911 transcriptional intermediary factor 1 alpha isoform ... 66 1e-10
>gi|164419758 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 1599 bits (4140), Expect = 0.0
Identities = 801/801 (100%), Positives = 801/801 (100%)
Query: 1 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN 60
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
Sbjct: 1 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN 60
Query: 61 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP 120
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
Sbjct: 61 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP 120
Query: 121 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM 180
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
Sbjct: 121 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM 180
Query: 181 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI 240
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
Sbjct: 181 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI 240
Query: 241 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA 300
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
Sbjct: 241 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA 300
Query: 301 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL 360
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
Sbjct: 301 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL 360
Query: 361 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL 420
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
Sbjct: 361 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL 420
Query: 421 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES 480
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
Sbjct: 421 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES 480
Query: 481 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG 540
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
Sbjct: 481 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG 540
Query: 541 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL 600
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
Sbjct: 541 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL 600
Query: 601 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE 660
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
Sbjct: 601 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE 660
Query: 661 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP 720
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
Sbjct: 661 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP 720
Query: 721 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS 780
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
Sbjct: 721 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS 780
Query: 781 SDSSSSSSSSSSSDTSDSDSG 801
SDSSSSSSSSSSSDTSDSDSG
Sbjct: 781 SDSSSSSSSSSSSDTSDSDSG 801
>gi|4826806 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 1599 bits (4140), Expect = 0.0
Identities = 801/801 (100%), Positives = 801/801 (100%)
Query: 1 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN 60
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
Sbjct: 1 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN 60
Query: 61 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP 120
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
Sbjct: 61 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP 120
Query: 121 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM 180
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
Sbjct: 121 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM 180
Query: 181 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI 240
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
Sbjct: 181 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI 240
Query: 241 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA 300
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
Sbjct: 241 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA 300
Query: 301 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL 360
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
Sbjct: 301 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL 360
Query: 361 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL 420
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
Sbjct: 361 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL 420
Query: 421 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES 480
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
Sbjct: 421 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES 480
Query: 481 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG 540
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
Sbjct: 481 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG 540
Query: 541 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL 600
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
Sbjct: 541 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL 600
Query: 601 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE 660
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
Sbjct: 601 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE 660
Query: 661 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP 720
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
Sbjct: 661 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP 720
Query: 721 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS 780
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
Sbjct: 721 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS 780
Query: 781 SDSSSSSSSSSSSDTSDSDSG 801
SDSSSSSSSSSSSDTSDSDSG
Sbjct: 781 SDSSSSSSSSSSSDTSDSDSG 801
>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
Length = 726
Score = 864 bits (2233), Expect = 0.0
Identities = 482/772 (62%), Positives = 549/772 (71%), Gaps = 76/772 (9%)
Query: 49 ASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKL 108
A +PA P NPPPPEVSNP KPGR TNQLQY+ VV+K LWKHQFAWPF QPVDA+KL
Sbjct: 10 AGIPATP-GPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKL 68
Query: 109 GLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQT 168
LPDYHKIIK PMDMGTIK+RLENNYYW+ASECMQDFNTMFTNCYIYNKPTDDIVLMAQ
Sbjct: 69 NLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQA 128
Query: 169 LEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALY- 227
LEKIFLQKVA MPQEE EL+ PK +K A A G+ QV AVSSVS +
Sbjct: 129 LEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGT----QQVAAVSSVSPATPFQ 184
Query: 228 --------------TPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPL 273
TP P I V ++P P + P P V PP P+
Sbjct: 185 SVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPP--------PPATPIVPVVPPTPPV 236
Query: 274 AKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPD 333
KKKGVKRKADTTTPT +AI A S + PP S +PK A++ R GRPIKPP+KDL D
Sbjct: 237 VKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQAKVVARRESGGRPIKPPKKDLED 295
Query: 334 SQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHP 393
+ + KKGKLSE L++C+ IL+E+LSKKHAAYAWPFYKPVDA AL LHDYHDIIKHP
Sbjct: 296 GEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHP 355
Query: 394 MDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKM 453
MDLSTVKRKM+ R+Y DAQ FAADVRLMFSNCYKYNPPDH+VVAMARKLQDVFE R+AKM
Sbjct: 356 MDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM 415
Query: 454 PDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESSSEEEEEEDEEDEEEEESESSDS 512
PDEP+E LP A P ++K + S SSEESSS+S SSDS
Sbjct: 416 PDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG------------------SSDS 455
Query: 513 EEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRK---AEKHRGRAGA 569
EEERA RLAELQEQL+AVHEQLAALSQ P++KPK+K+EKKEK+KK+K EK + + A
Sbjct: 456 EEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKA 515
Query: 570 DEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPT 629
+E+ K AP P + + KKA S +G +L KK K A
Sbjct: 516 EEEKKAKVAP-PAKQAQQKKAPAKKANSTTT----------AGRQL-KKGGKQA----SA 559
Query: 630 GYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFE 689
YDSEEEEE PMSYDEKRQLSLDIN+LPGEKLGRVVHIIQ+REPSLRDSNP+EIEIDFE
Sbjct: 560 SYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFE 619
Query: 690 TLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTKEELALEKKRELEKRLQDVSGQL 747
TLKP+TLRELERYV SCL+KK RKP++ KK K+KEELA EKK+ELEKRLQDVSGQL
Sbjct: 620 TLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQL 679
Query: 748 NSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSD 799
+S+KKP + K + SA SRLS SSSSS+S SSSSS SSSD+SDS+
Sbjct: 680 SSSKKPAR----KEKPGSAPSGGPSRLS-SSSSSESGSSSSSGSSSDSSDSE 726
>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
sapiens]
Length = 722
Score = 731 bits (1887), Expect = 0.0
Identities = 429/815 (52%), Positives = 518/815 (63%), Gaps = 139/815 (17%)
Query: 27 AAPGKRIRKPSLLYEGFESPTMASVPA-LQLTPAN-----PPPPEVSNPKKPGRVTNQLQ 80
+ PG R+R ++ +G E+ M++ A Q PAN PPPPE SNP KP R TNQLQ
Sbjct: 5 SGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQ 64
Query: 81 YLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASE 140
YL +VV+K LWKHQFAWPF+QPVDAVKL LPDY+KIIK PMDMGTIK+RLENNYYW A E
Sbjct: 65 YLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQE 124
Query: 141 CMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGA 200
C+QDFNTMFTNCYIYNKP DDIVLMA+ LEK+FLQK+ +P EE E+++ K +
Sbjct: 125 CIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGR--- 181
Query: 201 KLAALQGSVTSAHQVPAVSSVSHTALYTPPPEI------PTTVLNIPHP-------SVIS 247
G + P VS+V +T + PP+ P V PHP ++
Sbjct: 182 ------GRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQ 235
Query: 248 SPLLKSLH----SAGPPLLAVTAAPPA-----------------QPLAKKKGVKRKADTT 286
+P++ + PP+ PPA QP+ KKGVKRKADTT
Sbjct: 236 TPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTT 295
Query: 287 TPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKL 346
TPT T P+ PP EPK +L RRES RP+KPP+KD+PDSQQ K K+
Sbjct: 296 TPT-TIDPIHEPPSLPP---EPKTTKL-GQRRESSRPVKPPKKDVPDSQQHPAPEKSSKV 350
Query: 347 SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENR 406
SEQLK C+GILKE+ +KKHAAYAWPFYKPVD ALGLHDY DIIKHPMD+ST+K K+E R
Sbjct: 351 SEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAR 410
Query: 407 DYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVS 466
+YRDAQEF ADVRLMFSNCYKYNPPDH+VVAMARKLQDVFE R+AKMPDEP EP S
Sbjct: 411 EYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSS 470
Query: 467 TAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQ 526
A+PP K + SS +SSS+SSS + +S + DSEEERA RLAELQEQ
Sbjct: 471 PAVPPP-TKVVAPPSSSDSSSDSSS------------DSDSSTDDSEEERAQRLAELQEQ 517
Query: 527 LRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKK 586
L+AVHEQLAALSQ +KPK+K + K++KKK EKH+ + +E+ K +A PP PKK
Sbjct: 518 LKAVHEQLAALSQPQQNKPKKKEKDKKEKKK---EKHKRKEEVEENKKS-KAKEPP-PKK 572
Query: 587 SKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDE 646
+KK + S + P+ K+ PP PT Y+SEEE++ +PMSY+E
Sbjct: 573 TKKNNSSNSNVSKKEPA---------------PMKSKPP--PT-YESEEEDKCKPMSYEE 614
Query: 647 KRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSC 706
KRQLSLDINKLPGEKLGRVVHIIQ+REPSL++SNP+EIEIDFETLKPSTLRELERYV SC
Sbjct: 615 KRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC 674
Query: 707 LRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSA 766
LRKK RKP K V ++G
Sbjct: 675 LRKK-RKPQAEKVDV---------------------IAGS-------------------- 692
Query: 767 QQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG 801
S++ SSS S SSS SSSSD+ DS++G
Sbjct: 693 -----SKMKGFSSS--ESESSSESSSSDSEDSETG 720
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 731 bits (1886), Expect = 0.0
Identities = 418/771 (54%), Positives = 506/771 (65%), Gaps = 93/771 (12%)
Query: 27 AAPGKRIRKPSLLYEGFESPTMASVPA-LQLTPAN-----PPPPEVSNPKKPGRVTNQLQ 80
+ PG R+R ++ +G E+ M++ A Q PAN PPPPE SNP KP R TNQLQ
Sbjct: 5 SGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQ 64
Query: 81 YLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASE 140
YL +VV+K LWKHQFAWPF+QPVDAVKL LPDY+KIIK PMDMGTIK+RLENNYYW A E
Sbjct: 65 YLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQE 124
Query: 141 CMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGA 200
C+QDFNTMFTNCYIYNKP DDIVLMA+ LEK+FLQK+ +P EE E+++ K +
Sbjct: 125 CIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGR--- 181
Query: 201 KLAALQGSVTSAHQVPAVSSVSHTALYTPPPEI------PTTVLNIPHP-------SVIS 247
G + P VS+V +T + PP+ P V PHP ++
Sbjct: 182 ------GRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQ 235
Query: 248 SPLLKSLH----SAGPPLLAVTAAPPA-----------------QPLAKKKGVKRKADTT 286
+P++ + PP+ PPA QP+ KKGVKRKADTT
Sbjct: 236 TPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTT 295
Query: 287 TPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKL 346
TPT T P+ PP EPK +L RRES RP+KPP+KD+PDSQQ K K+
Sbjct: 296 TPT-TIDPIHEPPSLPP---EPKTTKL-GQRRESSRPVKPPKKDVPDSQQHPAPEKSSKV 350
Query: 347 SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENR 406
SEQLK C+GILKE+ +KKHAAYAWPFYKPVD ALGLHDY DIIKHPMD+ST+K K+E R
Sbjct: 351 SEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAR 410
Query: 407 DYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVS 466
+YRDAQEF ADVRLMFSNCYKYNPPDH+VVAMARKLQDVFE R+AKMPDEP EP S
Sbjct: 411 EYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSS 470
Query: 467 TAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQ 526
A+PP K + SS +SSS+SSS + +S + DSEEERA RLAELQEQ
Sbjct: 471 PAVPPP-TKVVAPPSSSDSSSDSSS------------DSDSSTDDSEEERAQRLAELQEQ 517
Query: 527 LRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKK 586
L+AVHEQLAALSQ +KPK+K + K++KKK EKH+ + +E+ K +A PP PKK
Sbjct: 518 LKAVHEQLAALSQPQQNKPKKKEKDKKEKKK---EKHKRKEEVEENKKS-KAKEPP-PKK 572
Query: 587 SKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDE 646
+KK + S + P+ K+ PP PT Y+SEEE++ +PMSY+E
Sbjct: 573 TKKNNSSNSNVSKKEPA---------------PMKSKPP--PT-YESEEEDKCKPMSYEE 614
Query: 647 KRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSC 706
KRQLSLDINKLPGEKLGRVVHIIQ+REPSL++SNP+EIEIDFETLKPSTLRELERYV SC
Sbjct: 615 KRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSC 674
Query: 707 LRKKPRKPYTIKKPV--GKTKEELALEKKRELEKRLQDVSGQLNSTKKPPK 755
LRKK RKP K V G +K + + E + + T+ PK
Sbjct: 675 LRKK-RKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPK 724
Score = 107 bits (266), Expect = 6e-23
Identities = 114/489 (23%), Positives = 189/489 (38%), Gaps = 50/489 (10%)
Query: 332 PDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIK 391
P + +K + + QL++ ++ + L K +AWPF +PVDA L L DY+ IIK
Sbjct: 45 PPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQ--FAWPFQQPVDAVKLNLPDYYKIIK 102
Query: 392 HPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYA 451
PMD+ T+K+++EN Y +AQE D MF+NCY YN P D+V MA L+ +F +
Sbjct: 103 TPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKIN 162
Query: 452 KMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSD 511
++P E E + G + E+ + + S+ + + + +
Sbjct: 163 ELPTEETE-----IMIVQAKGRGRGRKETGTAKPGV-STVPNTTQASTPPQTQTPQPNPP 216
Query: 512 SEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADE 571
+ H + L + + P+ P + + + +
Sbjct: 217 PVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHP---- 272
Query: 572 DDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGY 631
P PQP K+KK G + T P + PP T
Sbjct: 273 ----PIIAATPQPVKTKK-----------GVKRKADTTTPTTIDPIHEPPSLPPEPKTTK 317
Query: 632 DSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEE-IEIDFET 690
+ E SRP+ +K + P EK +V ++ L++ ++ +
Sbjct: 318 LGQRRESSRPVKPPKKDVPDSQQHPAP-EKSSKVSEQLKCCSGILKEMFAKKHAAYAWPF 376
Query: 691 LKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE------------- 737
KP + L + + K P TIK + + A E ++
Sbjct: 377 YKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPD 436
Query: 738 -------KRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSS 790
++LQDV ++ K P + SS +++ A SSSDSSS SSS
Sbjct: 437 HEVVAMARKLQDVF-EMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSD 495
Query: 791 SSSDTSDSD 799
S S T DS+
Sbjct: 496 SDSSTDDSE 504
Score = 37.7 bits (86), Expect = 0.043
Identities = 34/121 (28%), Positives = 44/121 (36%), Gaps = 7/121 (5%)
Query: 222 SHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPP-LLAVTAAPPAQPLAKKKGVK 280
+ A P P P V P++ +PLL A PP +L PPA PL +
Sbjct: 875 NRAAALPPKPARPPAV----SPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQL 930
Query: 281 RKADTTTPTPTAILAPGSP--ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQH 338
P L P + PP L P + + P PP + P QQQH
Sbjct: 931 YLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQH 990
Query: 339 Q 339
Q
Sbjct: 991 Q 991
Score = 35.0 bits (79), Expect = 0.28
Identities = 28/124 (22%), Positives = 56/124 (45%), Gaps = 19/124 (15%)
Query: 470 PPGLAKSSSESSSEESSSESSSEEEEE--EDEEDEEEEESESSDSEEERAHRLAELQEQL 527
P AKSSS+S + + EE E+ + + + E+E E E R+ + EQ
Sbjct: 1213 PSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQA 1272
Query: 528 RAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKS 587
R HE+ R+R++++++++++ ++ + + A A PQ + S
Sbjct: 1273 RRAHEEA------------RRRQEQQQQQRQEQQQQQQQQAA-----AVAAAATPQAQSS 1315
Query: 588 KKAS 591
+ S
Sbjct: 1316 QPQS 1319
Score = 33.9 bits (76), Expect = 0.61
Identities = 22/81 (27%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 472 GLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVH 531
G + S SESSSE SSS+ SE+ E E +++ + ++ H ++Q+ V
Sbjct: 697 GFSSSESESSSESSSSD--SEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVP 754
Query: 532 EQLAALSQGPISKPKRKREKK 552
+Q Q P P +++++
Sbjct: 755 QQPPPPPQQPPPPPPPQQQQQ 775
Score = 33.9 bits (76), Expect = 0.61
Identities = 26/114 (22%), Positives = 55/114 (48%), Gaps = 17/114 (14%)
Query: 471 PGLAKSSSESSSE--ESSSESSSEEEEEED----EEDEEEEESESSDSEEERAHRLAELQ 524
P S+++SSS+ E ++ E+EE E + + E+E E E R+ +
Sbjct: 1210 PTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDAL 1269
Query: 525 EQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRA 578
EQ R HE+ +R++E+++++++ + ++ + +A A P+A
Sbjct: 1270 EQARRAHEE-----------ARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQA 1312
Score = 32.3 bits (72), Expect = 1.8
Identities = 18/68 (26%), Positives = 31/68 (45%), Gaps = 3/68 (4%)
Query: 480 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539
SS + S S SE E D E+ E+E + +++ H E ++ H+Q + Q
Sbjct: 692 SSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQ---MQQ 748
Query: 540 GPISKPKR 547
P P++
Sbjct: 749 APAPVPQQ 756
Score = 32.0 bits (71), Expect = 2.3
Identities = 17/45 (37%), Positives = 27/45 (60%), Gaps = 1/45 (2%)
Query: 723 KTKEELALEKKRELEKRLQDV-SGQLNSTKKPPKKANEKTESSSA 766
K KE+ EKK+E KR ++V + + K+PP K +K SS++
Sbjct: 537 KKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNS 581
Score = 32.0 bits (71), Expect = 2.3
Identities = 35/129 (27%), Positives = 46/129 (35%), Gaps = 33/129 (25%)
Query: 241 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA 300
P P +I SP + S +PP Q + KK R A P P ++
Sbjct: 1063 PSPLMIHSPQMSQFQSL------THQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIH 1116
Query: 301 SPPGSLEPKAARL---PPMRRES------------------GRP-IKPPRKD-----LPD 333
SP EP + L PP ES GRP I+PP ++ PD
Sbjct: 1117 SPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPD 1176
Query: 334 SQQQHQSSK 342
+Q Q K
Sbjct: 1177 KDKQKQEPK 1185
>gi|46399200 testis-specific bromodomain protein [Homo sapiens]
Length = 947
Score = 654 bits (1686), Expect = 0.0
Identities = 384/745 (51%), Positives = 488/745 (65%), Gaps = 94/745 (12%)
Query: 60 NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ 119
NPPPPE N KK GR+TNQLQYL KVV+K LWKH F+WPF++PVDAVKL LPDY+ IIK
Sbjct: 13 NPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKN 72
Query: 120 PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS 179
PMD+ TIK+RLEN YY ASEC++DFNTMF+NCY+YNKP DDIVLMAQ LEK+F+QK++
Sbjct: 73 PMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
Query: 180 MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN 239
MPQEEQ + V K KKG + +V+SA + SS S T EIP+
Sbjct: 133 MPQEEQVVGV---KERIKKGTQQNI---AVSSAKEK---SSPSATEKVFKQQEIPSVF-- 181
Query: 240 IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP 299
P SPL + A + TAA KGVKRKADTTTP +A+ A S
Sbjct: 182 ---PKTSISPL-NVVQGASVNSSSQTAAQVT------KGVKRKADTTTPATSAVKA-SSE 230
Query: 300 ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE 359
SP + K+ LPP++ P+ LPDSQQQ+ K K++EQL+HC+ ILKE
Sbjct: 231 FSP--TFTEKSVALPPIKENM------PKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKE 282
Query: 360 LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR 419
+L+KKH +YAWPFY PVD +ALGLH+Y+D++K+PMDL T+K KM+N++Y+DA +FAADVR
Sbjct: 283 MLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVR 342
Query: 420 LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSE 479
LMF NCYKYNPPDH+VV MAR LQDVFE ++K+P EP+E PL + +E
Sbjct: 343 LMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCY-------IKTDITE 395
Query: 480 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539
++ E+++E+SSE + S DSE+ER RLA+LQEQL+AVH+QL LSQ
Sbjct: 396 TTGRENTNEASSEG-------------NSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQ 442
Query: 540 GPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAA 599
P K +K+EK +K+KK++ + ++ PR K K
Sbjct: 443 VPFRKLNKKKEKSKKEKKKEK--------VNNSNENPRKMCEQMRLKEK----------- 483
Query: 600 LGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPG 659
S PKK + G SE+E+ ++PM+YDEKRQLSL+INKLPG
Sbjct: 484 -----------SKRNQPKKRKQQF-----IGLKSEDEDNAKPMNYDEKRQLSLNINKLPG 527
Query: 660 EKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKK 719
+KLGRVVHIIQ+REPSL +SNP+EIEIDFETLK STLRELE+YV +CLRK+P KP K
Sbjct: 528 DKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPA--K 585
Query: 720 PVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSS 779
+ +KEEL +KK+ELEKRL DV+ QLNS K+ K ++KT+ S A + VSRLS SSS
Sbjct: 586 KIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTK--SDKTQPSKAVE-NVSRLSESSS 642
Query: 780 SSDSSSSSSSS----SSSDTSDSDS 800
SS SSS S SS SSSD+SDS+S
Sbjct: 643 SSSSSSESESSSSDLSSSDSSDSES 667
Score = 31.2 bits (69), Expect = 4.0
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQ 524
E+ S S S SSS E + + S+SSDSE E + E++
Sbjct: 632 ENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVK 677
>gi|46399198 testis-specific bromodomain protein [Homo sapiens]
Length = 947
Score = 654 bits (1686), Expect = 0.0
Identities = 384/745 (51%), Positives = 488/745 (65%), Gaps = 94/745 (12%)
Query: 60 NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ 119
NPPPPE N KK GR+TNQLQYL KVV+K LWKH F+WPF++PVDAVKL LPDY+ IIK
Sbjct: 13 NPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKN 72
Query: 120 PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS 179
PMD+ TIK+RLEN YY ASEC++DFNTMF+NCY+YNKP DDIVLMAQ LEK+F+QK++
Sbjct: 73 PMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQ 132
Query: 180 MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN 239
MPQEEQ + V K KKG + +V+SA + SS S T EIP+
Sbjct: 133 MPQEEQVVGV---KERIKKGTQQNI---AVSSAKEK---SSPSATEKVFKQQEIPSVF-- 181
Query: 240 IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP 299
P SPL + A + TAA KGVKRKADTTTP +A+ A S
Sbjct: 182 ---PKTSISPL-NVVQGASVNSSSQTAAQVT------KGVKRKADTTTPATSAVKA-SSE 230
Query: 300 ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE 359
SP + K+ LPP++ P+ LPDSQQQ+ K K++EQL+HC+ ILKE
Sbjct: 231 FSP--TFTEKSVALPPIKENM------PKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKE 282
Query: 360 LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR 419
+L+KKH +YAWPFY PVD +ALGLH+Y+D++K+PMDL T+K KM+N++Y+DA +FAADVR
Sbjct: 283 MLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVR 342
Query: 420 LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSE 479
LMF NCYKYNPPDH+VV MAR LQDVFE ++K+P EP+E PL + +E
Sbjct: 343 LMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCY-------IKTDITE 395
Query: 480 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQ 539
++ E+++E+SSE + S DSE+ER RLA+LQEQL+AVH+QL LSQ
Sbjct: 396 TTGRENTNEASSEG-------------NSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQ 442
Query: 540 GPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAA 599
P K +K+EK +K+KK++ + ++ PR K K
Sbjct: 443 VPFRKLNKKKEKSKKEKKKEK--------VNNSNENPRKMCEQMRLKEK----------- 483
Query: 600 LGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPG 659
S PKK + G SE+E+ ++PM+YDEKRQLSL+INKLPG
Sbjct: 484 -----------SKRNQPKKRKQQF-----IGLKSEDEDNAKPMNYDEKRQLSLNINKLPG 527
Query: 660 EKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKK 719
+KLGRVVHIIQ+REPSL +SNP+EIEIDFETLK STLRELE+YV +CLRK+P KP K
Sbjct: 528 DKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPA--K 585
Query: 720 PVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSS 779
+ +KEEL +KK+ELEKRL DV+ QLNS K+ K ++KT+ S A + VSRLS SSS
Sbjct: 586 KIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTK--SDKTQPSKAVE-NVSRLSESSS 642
Query: 780 SSDSSSSSSSS----SSSDTSDSDS 800
SS SSS S SS SSSD+SDS+S
Sbjct: 643 SSSSSSESESSSSDLSSSDSSDSES 667
Score = 31.2 bits (69), Expect = 4.0
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQ 524
E+ S S S SSS E + + S+SSDSE E + E++
Sbjct: 632 ENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVK 677
>gi|119943102 CREB binding protein isoform b [Homo sapiens]
Length = 2404
Score = 91.3 bits (225), Expect = 3e-18
Identities = 112/482 (23%), Positives = 174/482 (36%), Gaps = 90/482 (18%)
Query: 22 LGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQY 81
+GP AA+P + + +M SVP + ++P+ P P P G TN +
Sbjct: 701 MGPRAASP---------MNHSVQMNSMGSVPGMAISPSRMPQP----PNMMGAHTNNMMA 747
Query: 82 LHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASEC 141
+ L ++QF P +V +G P + Q G L N +
Sbjct: 748 QAPAQSQFLPQNQF--PSSSGAMSVGMGQPPAQTGVSQGQVPGAA---LPNPLNMLGPQA 802
Query: 142 MQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAK 201
Q T ++ P + + PQ + P +S G
Sbjct: 803 SQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSS--SGQT 860
Query: 202 LAALQGSVTSAHQVPAVSSVSHTAL--YTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGP 259
GSV SA Q + +V A TP P+ P P +++P S+
Sbjct: 861 PTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPV------QPPSVATP-----QSSQQ 909
Query: 260 PLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRE 319
V A PP PL++ D PTP+++ + + + PG P + E
Sbjct: 910 QPTPVHAQPPGTPLSQAAA---SIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAE 966
Query: 320 SGRPIKPPRKDLPDSQQQHQS------------------------SKKGKLSEQLKH--- 352
P K P S+ + KK ++ ++K
Sbjct: 967 DTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEE 1026
Query: 353 --CNGILKE--------------------LLSKKHAAY-----AWPFYKPVDASALGLHD 385
NG + L+ A Y + PF +PVD LG+ D
Sbjct: 1027 SSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD 1086
Query: 386 YHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV 445
Y DI+K+PMDLST+KRK++ Y++ ++ DV LMF+N + YN V KL +V
Sbjct: 1087 YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEV 1146
Query: 446 FE 447
FE
Sbjct: 1147 FE 1148
Score = 76.3 bits (186), Expect = 1e-13
Identities = 40/117 (34%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Query: 67 SNPKKPGRVTNQLQYLHKVVMKALWKHQ-FAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT 125
S P+K +L+ ++AL++ + PFRQPVD LG+PDY I+K PMD+ T
Sbjct: 1040 SQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLST 1099
Query: 126 IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQ 182
IKR+L+ Y + + D MF N ++YN+ T + L ++F Q++ + Q
Sbjct: 1100 IKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQ 1156
Score = 35.4 bits (80), Expect = 0.21
Identities = 34/136 (25%), Positives = 59/136 (43%), Gaps = 15/136 (11%)
Query: 459 EPGP-LPV----------STAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEES 507
+PGP +PV T PG +K S E + +S+ +E E D E++S
Sbjct: 949 QPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKE---ETDIAEQKS 1005
Query: 508 ESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRA 567
E + +E++ E++E+ + A+ S P S+P++K K E+ ++
Sbjct: 1006 EPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSP-SQPRKKIFKPEELRQALMPTLEALY 1064
Query: 568 GADEDDKGPRAPRPPQ 583
D + R P PQ
Sbjct: 1065 RQDPESLPFRQPVDPQ 1080
Score = 34.7 bits (78), Expect = 0.36
Identities = 31/115 (26%), Positives = 49/115 (42%), Gaps = 16/115 (13%)
Query: 224 TALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKA 283
T + TP ++ LN+P P+ +S P++ S+ P P QP+ G+ R
Sbjct: 1948 TGMGTPGSQMAPVSLNVPRPNQVSGPVMPSM---PPGQWQQAPLPQQQPM---PGLPRPV 2001
Query: 284 DTTTPTPTAILAPGSPA-SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQ 337
+ A+ P P+ PP S+ P A ++ R +K P P QQQ
Sbjct: 2002 -ISMQAQAAVAGPRMPSVQPPRSISPSAL------QDLLRTLKSPSS--PQQQQQ 2047
Score = 30.0 bits (66), Expect = 8.9
Identities = 19/79 (24%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 488 ESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKR 547
ES E E+EE+E +EE + S +E + ++ + ++ +++S+ KP
Sbjct: 1513 ESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSM 1572
Query: 548 KREKKEKKKKRKA--EKHR 564
+ +K A EKH+
Sbjct: 1573 PNVSNDLSQKLYATMEKHK 1591
>gi|119943104 CREB binding protein isoform a [Homo sapiens]
Length = 2442
Score = 91.3 bits (225), Expect = 3e-18
Identities = 112/482 (23%), Positives = 174/482 (36%), Gaps = 90/482 (18%)
Query: 22 LGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQY 81
+GP AA+P + + +M SVP + ++P+ P P P G TN +
Sbjct: 739 MGPRAASP---------MNHSVQMNSMGSVPGMAISPSRMPQP----PNMMGAHTNNMMA 785
Query: 82 LHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASEC 141
+ L ++QF P +V +G P + Q G L N +
Sbjct: 786 QAPAQSQFLPQNQF--PSSSGAMSVGMGQPPAQTGVSQGQVPGAA---LPNPLNMLGPQA 840
Query: 142 MQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAK 201
Q T ++ P + + PQ + P +S G
Sbjct: 841 SQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSS--SGQT 898
Query: 202 LAALQGSVTSAHQVPAVSSVSHTAL--YTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGP 259
GSV SA Q + +V A TP P+ P P +++P S+
Sbjct: 899 PTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPV------QPPSVATP-----QSSQQ 947
Query: 260 PLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRE 319
V A PP PL++ D PTP+++ + + + PG P + E
Sbjct: 948 QPTPVHAQPPGTPLSQAAA---SIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAE 1004
Query: 320 SGRPIKPPRKDLPDSQQQHQS------------------------SKKGKLSEQLKH--- 352
P K P S+ + KK ++ ++K
Sbjct: 1005 DTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEE 1064
Query: 353 --CNGILKE--------------------LLSKKHAAY-----AWPFYKPVDASALGLHD 385
NG + L+ A Y + PF +PVD LG+ D
Sbjct: 1065 SSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD 1124
Query: 386 YHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV 445
Y DI+K+PMDLST+KRK++ Y++ ++ DV LMF+N + YN V KL +V
Sbjct: 1125 YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEV 1184
Query: 446 FE 447
FE
Sbjct: 1185 FE 1186
Score = 76.3 bits (186), Expect = 1e-13
Identities = 40/117 (34%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Query: 67 SNPKKPGRVTNQLQYLHKVVMKALWKHQ-FAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT 125
S P+K +L+ ++AL++ + PFRQPVD LG+PDY I+K PMD+ T
Sbjct: 1078 SQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLST 1137
Query: 126 IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQ 182
IKR+L+ Y + + D MF N ++YN+ T + L ++F Q++ + Q
Sbjct: 1138 IKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQ 1194
Score = 35.4 bits (80), Expect = 0.21
Identities = 34/136 (25%), Positives = 59/136 (43%), Gaps = 15/136 (11%)
Query: 459 EPGP-LPV----------STAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEES 507
+PGP +PV T PG +K S E + +S+ +E E D E++S
Sbjct: 987 QPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKE---ETDIAEQKS 1043
Query: 508 ESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRA 567
E + +E++ E++E+ + A+ S P S+P++K K E+ ++
Sbjct: 1044 EPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSP-SQPRKKIFKPEELRQALMPTLEALY 1102
Query: 568 GADEDDKGPRAPRPPQ 583
D + R P PQ
Sbjct: 1103 RQDPESLPFRQPVDPQ 1118
Score = 34.7 bits (78), Expect = 0.36
Identities = 31/115 (26%), Positives = 49/115 (42%), Gaps = 16/115 (13%)
Query: 224 TALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKA 283
T + TP ++ LN+P P+ +S P++ S+ P P QP+ G+ R
Sbjct: 1986 TGMGTPGSQMAPVSLNVPRPNQVSGPVMPSM---PPGQWQQAPLPQQQPM---PGLPRPV 2039
Query: 284 DTTTPTPTAILAPGSPA-SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQ 337
+ A+ P P+ PP S+ P A ++ R +K P P QQQ
Sbjct: 2040 -ISMQAQAAVAGPRMPSVQPPRSISPSAL------QDLLRTLKSPSS--PQQQQQ 2085
Score = 30.0 bits (66), Expect = 8.9
Identities = 19/79 (24%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 488 ESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKR 547
ES E E+EE+E +EE + S +E + ++ + ++ +++S+ KP
Sbjct: 1551 ESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSM 1610
Query: 548 KREKKEKKKKRKA--EKHR 564
+ +K A EKH+
Sbjct: 1611 PNVSNDLSQKLYATMEKHK 1629
>gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens]
Length = 832
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/141 (34%), Positives = 71/141 (50%), Gaps = 5/141 (3%)
Query: 37 SLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFA 96
S +G + S+P ++ T P E S K R +QL K +++ + HQ A
Sbjct: 689 SCFKDGVRQIPIESIPGIRETGWKPSGKEKS---KEPRDPDQLYSTLKSILQQVKSHQSA 745
Query: 97 WPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYN 156
WPF +PV + P Y+++I+ PMD+ T+ RL+N YY + M D +FTNC YN
Sbjct: 746 WPFMEPVKRTEA--PGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYN 803
Query: 157 KPTDDIVLMAQTLEKIFLQKV 177
P + A LEK F K+
Sbjct: 804 PPESEYYKCANILEKFFFSKI 824
Score = 67.8 bits (164), Expect = 4e-11
Identities = 44/174 (25%), Positives = 76/174 (43%), Gaps = 16/174 (9%)
Query: 273 LAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLP 332
+ K+K + +K + PG G + +P +R +P + P
Sbjct: 663 IKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEP 722
Query: 333 DSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKH 392
Q S+ K L + H + AWPF +PV + Y+++I+
Sbjct: 723 RDPDQLYSTLKSILQQVKSHQS--------------AWPFMEPVKRTEAP--GYYEVIRF 766
Query: 393 PMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF 446
PMDL T+ +++NR Y + F AD++ +F+NC +YNPP+ + A L+ F
Sbjct: 767 PMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFF 820
Score = 30.4 bits (67), Expect = 6.8
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 10/69 (14%)
Query: 567 AGADEDDKGPR-APRPPQPKKSKKASGSGGGSAALGP--------SGFGPSGGSGTKLP- 616
AGA P+ A PP P + + + GGS A GP + GP GG ++
Sbjct: 18 AGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAV 77
Query: 617 KKATKTAPP 625
KKA + P
Sbjct: 78 KKAQLRSAP 86
>gi|50345997 E1A binding protein p300 [Homo sapiens]
Length = 2414
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/244 (27%), Positives = 107/244 (43%), Gaps = 17/244 (6%)
Query: 212 AHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSV---ISSPLLKSLHSAGPPLLAVTAAP 268
+ Q A S + TA PP P T L+ P S+ +S+P S S A+
Sbjct: 916 SQQSTAASVPTPTAPLLPPQ--PATPLSQPAVSIEGQVSNP--PSTSSTEVNSQAIAEKQ 971
Query: 269 PAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPR 328
P+Q + ++ K + P P S + ++ E IK
Sbjct: 972 PSQEVK----MEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKE-E 1026
Query: 329 KDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAY-----AWPFYKPVDASALGL 383
+D P + S G+ +++ + + L+ A Y + PF +PVD LG+
Sbjct: 1027 EDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGI 1086
Query: 384 HDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQ 443
DY DI+K PMDLST+KRK++ Y++ ++ D+ LMF+N + YN V KL
Sbjct: 1087 PDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLS 1146
Query: 444 DVFE 447
+VFE
Sbjct: 1147 EVFE 1150
Score = 77.4 bits (189), Expect = 5e-14
Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 4/132 (3%)
Query: 52 PALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQ-FAWPFRQPVDAVKLGL 110
P+ T ++P P + KK +L+ ++AL++ + PFRQPVD LG+
Sbjct: 1030 PSTSATQSSPAPGQ---SKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGI 1086
Query: 111 PDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLE 170
PDY I+K PMD+ TIKR+L+ Y + + D MF N ++YN+ T + L
Sbjct: 1087 PDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLS 1146
Query: 171 KIFLQKVASMPQ 182
++F Q++ + Q
Sbjct: 1147 EVFEQEIDPVMQ 1158
Score = 35.0 bits (79), Expect = 0.28
Identities = 68/298 (22%), Positives = 111/298 (37%), Gaps = 48/298 (16%)
Query: 253 SLHSAGP-PLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA 311
+LH P P+ + T P P G ++ TT P P P PA PPG P++
Sbjct: 826 ALHQNSPSPVPSRTPTPHHTP--PSIGAQQPPATTIPAPV----PTPPAMPPG---PQSQ 876
Query: 312 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP 371
L P R++ P P LP QQ Q S S ++ + P
Sbjct: 877 ALHPPPRQTPTP---PTTQLP---QQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAP 930
Query: 372 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP 431
P A+ L +++ ++ N + E + S P
Sbjct: 931 LLPPQPATPLS-----------QPAVSIEGQVSNPPSTSSTE-------VNSQAIAEKQP 972
Query: 432 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSS 491
+V A+ D EP + P +S + S+E+ EE S+E +
Sbjct: 973 SQEVKMEAKMEVD---------QPEPADTQPEDISESKVEDCKMESTET--EERSTELKT 1021
Query: 492 EEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAAL-SQGPISKPKRK 548
E +EEED+ +S + + ++ ++ + +E +A+ L AL Q P S P R+
Sbjct: 1022 EIKEEEDQPSTSATQSSPAPGQSKK--KIFKPEELRQALMPTLEALYRQDPESLPFRQ 1077
Score = 32.7 bits (73), Expect = 1.4
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 8/100 (8%)
Query: 210 TSAHQVPAVSSVSHTALYTPPPEIPTTVLNIP-------HPSVISSPLLKSLHSAGPPLL 262
T H P++ + A P P +PT P HP +P +
Sbjct: 841 TPHHTPPSIGAQQPPATTIPAP-VPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQP 899
Query: 263 AVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASP 302
++ AAP A ++ ++ + PTPTA L P PA+P
Sbjct: 900 SLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATP 939
Score = 32.0 bits (71), Expect = 2.3
Identities = 23/82 (28%), Positives = 28/82 (34%), Gaps = 1/82 (1%)
Query: 226 LYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADT 285
L +P P PTT P+ +P S PP P Q K
Sbjct: 1847 LPSPTPATPTTPTG-QQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQV 1905
Query: 286 TTPTPTAILAPGSPASPPGSLE 307
T PTP P P PP ++E
Sbjct: 1906 TPPTPPQTAQPPLPGPPPAAVE 1927
Score = 31.6 bits (70), Expect = 3.0
Identities = 22/84 (26%), Positives = 39/84 (46%), Gaps = 7/84 (8%)
Query: 483 EESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPI 542
EES E EEEE + EE+ E ++ + + + A + + + + ++LS+G
Sbjct: 1514 EESIKELEQEEEERKREENTSNESTDVTKGDSKNAKK-----KNNKKTSKNKSSLSRGNK 1568
Query: 543 SKPKRKREKKEKKKKRKA--EKHR 564
KP + +K A EKH+
Sbjct: 1569 KKPGMPNVSNDLSQKLYATMEKHK 1592
>gi|38788260 bromodomain PHD finger transcription factor isoform 2
[Homo sapiens]
Length = 2903
Score = 77.8 bits (190), Expect = 4e-14
Identities = 36/94 (38%), Positives = 55/94 (58%), Gaps = 2/94 (2%)
Query: 84 KVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQ 143
K V+++L H+ AWPF +PVD PDY+ +IK+PMD+ T++ R++ YY +E +
Sbjct: 2794 KRVLRSLQAHKMAWPFLEPVDPNDA--PDYYGVIKEPMDLATMEERVQRRYYEKLTEFVA 2851
Query: 144 DFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKV 177
D +F NC YN A+ LE F+QK+
Sbjct: 2852 DMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKL 2885
Score = 70.5 bits (171), Expect = 6e-12
Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 2/96 (2%)
Query: 351 KHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRD 410
K G+ + L S + AWPF +PVD + DY+ +IK PMDL+T++ +++ R Y
Sbjct: 2788 KDYEGLKRVLRSLQAHKMAWPFLEPVDPN--DAPDYYGVIKEPMDLATMEERVQRRYYEK 2845
Query: 411 AQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF 446
EF AD+ +F NC YNP D A L+ F
Sbjct: 2846 LTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFF 2881
Score = 39.7 bits (91), Expect = 0.011
Identities = 43/172 (25%), Positives = 69/172 (40%), Gaps = 5/172 (2%)
Query: 566 RAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPP 625
R G+ K P P PP P S A G GG G +G G GG + A +
Sbjct: 68 RGGSSSRRKPP--PPPPAPP-STSAPGRGGRGGGGGRTGGGGGGGHLARTTA-ARRAVNK 123
Query: 626 ALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIE 685
+ ++SEEEEE M +E+ + D + + + + + S E+ +
Sbjct: 124 VVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDD 183
Query: 686 IDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE 737
D S+ R Y + R+KPR + + P+ + K+ LE + E
Sbjct: 184 DDASYCTESSFRSHSTYSSTPGRRKPR-VHRPRSPILEEKDIPPLEFPKSSE 234
Score = 38.1 bits (87), Expect = 0.033
Identities = 17/36 (47%), Positives = 23/36 (63%)
Query: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEE 514
ES EE + SEEEEEED + EE ++SE + +E
Sbjct: 130 ESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDE 165
Score = 35.0 bits (79), Expect = 0.28
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEE 515
+ SEE E EEEE+E+ + EE +S D EE+
Sbjct: 128 DHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEED 164
Score = 34.3 bits (77), Expect = 0.47
Identities = 18/55 (32%), Positives = 27/55 (49%)
Query: 461 GPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEE 515
G L +TA + K + E E EEE+EED + EE++ S+ +EE
Sbjct: 109 GHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEE 163
Score = 32.7 bits (73), Expect = 1.4
Identities = 16/39 (41%), Positives = 24/39 (61%), Gaps = 4/39 (10%)
Query: 488 ESSSEEEEE----EDEEDEEEEESESSDSEEERAHRLAE 522
ES EEEEE E+EE+E+ + E+ DSE++ + E
Sbjct: 130 ESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEE 168
Score = 32.7 bits (73), Expect = 1.4
Identities = 39/195 (20%), Positives = 78/195 (40%), Gaps = 11/195 (5%)
Query: 617 KKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSL 676
K+ +P + DSE++E + Q +DI+K+ +K V ++ +
Sbjct: 1077 KRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKP 1136
Query: 677 RDSNPEEIEIDFETLKPSTLRE---------LERYVLSCLRKKPRKPYTIKKPVGKTKEE 727
P E++ D +T +E E + L KK K + + + ++
Sbjct: 1137 CKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQ 1196
Query: 728 LALEKKRELEK-RLQ-DVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS 785
LE+K+ LEK +L+ + G ++ K +E + A++ S S ++++
Sbjct: 1197 FTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANN 1256
Query: 786 SSSSSSSSDTSDSDS 800
S+SDS
Sbjct: 1257 DQPEDLIQGCSESDS 1271
Score = 32.3 bits (72), Expect = 1.8
Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 2/38 (5%)
Query: 490 SSEEEEEED--EEDEEEEESESSDSEEERAHRLAELQE 525
S EEEEEED E+EEEE+ ++ ++++ E++E
Sbjct: 131 SEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEE 168
Score = 32.0 bits (71), Expect = 2.3
Identities = 40/163 (24%), Positives = 63/163 (38%), Gaps = 24/163 (14%)
Query: 492 EEEEEEDEEDEEEEESESSDSEEERAHRLAEL----QEQLRAVHEQLAALSQGPISKPKR 547
++EE++ + + EES ++ A +L+ L +EQLRA + AL + +
Sbjct: 2566 DKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQ 2625
Query: 548 KREKKEKK-KKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFG 606
+ K++ K KK K +A A P P PP P A PS
Sbjct: 2626 EELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAP-------------PAPPPSPPP 2672
Query: 607 PSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQ 649
P T L + P LP + EE + S K++
Sbjct: 2673 PPAVQHTGL------LSTPTLPAASQKRKREEEKDSSSKSKKK 2709
Score = 31.2 bits (69), Expect = 4.0
Identities = 12/72 (16%), Positives = 33/72 (45%)
Query: 475 KSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQL 534
+ E E + +S +EE+E +E+D++ + E + +++ A E + + +
Sbjct: 144 EEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSST 203
Query: 535 AALSQGPISKPK 546
+ + +P+
Sbjct: 204 PGRRKPRVHRPR 215
Score = 30.0 bits (66), Expect = 8.9
Identities = 18/49 (36%), Positives = 28/49 (57%), Gaps = 2/49 (4%)
Query: 466 STAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEE 514
+T++ P L S+ SSSE +SS+S S + ++ E E E + S EE
Sbjct: 700 TTSIQPNLENSN--SSSELNSSQSESAKAADDPENGERESHTPVSIQEE 746
>gi|38788274 bromodomain PHD finger transcription factor isoform 1
[Homo sapiens]
Length = 2920
Score = 77.8 bits (190), Expect = 4e-14
Identities = 36/94 (38%), Positives = 55/94 (58%), Gaps = 2/94 (2%)
Query: 84 KVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQ 143
K V+++L H+ AWPF +PVD PDY+ +IK+PMD+ T++ R++ YY +E +
Sbjct: 2811 KRVLRSLQAHKMAWPFLEPVDPNDA--PDYYGVIKEPMDLATMEERVQRRYYEKLTEFVA 2868
Query: 144 DFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKV 177
D +F NC YN A+ LE F+QK+
Sbjct: 2869 DMTKIFDNCRYYNPSDSPFYQCAEVLESFFVQKL 2902
Score = 70.5 bits (171), Expect = 6e-12
Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 2/96 (2%)
Query: 351 KHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRD 410
K G+ + L S + AWPF +PVD + DY+ +IK PMDL+T++ +++ R Y
Sbjct: 2805 KDYEGLKRVLRSLQAHKMAWPFLEPVDPN--DAPDYYGVIKEPMDLATMEERVQRRYYEK 2862
Query: 411 AQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF 446
EF AD+ +F NC YNP D A L+ F
Sbjct: 2863 LTEFVADMTKIFDNCRYYNPSDSPFYQCAEVLESFF 2898
Score = 39.7 bits (91), Expect = 0.011
Identities = 43/172 (25%), Positives = 69/172 (40%), Gaps = 5/172 (2%)
Query: 566 RAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPP 625
R G+ K P P PP P S A G GG G +G G GG + A +
Sbjct: 68 RGGSSSRRKPP--PPPPAPP-STSAPGRGGRGGGGGRTGGGGGGGHLARTTA-ARRAVNK 123
Query: 626 ALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIE 685
+ ++SEEEEE M +E+ + D + + + + + S E+ +
Sbjct: 124 VVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDD 183
Query: 686 IDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE 737
D S+ R Y + R+KPR + + P+ + K+ LE + E
Sbjct: 184 DDASYCTESSFRSHSTYSSTPGRRKPR-VHRPRSPILEEKDIPPLEFPKSSE 234
Score = 38.1 bits (87), Expect = 0.033
Identities = 17/36 (47%), Positives = 23/36 (63%)
Query: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEE 514
ES EE + SEEEEEED + EE ++SE + +E
Sbjct: 130 ESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDE 165
Score = 35.0 bits (79), Expect = 0.28
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 479 ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEE 515
+ SEE E EEEE+E+ + EE +S D EE+
Sbjct: 128 DHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEED 164
Score = 34.3 bits (77), Expect = 0.47
Identities = 18/55 (32%), Positives = 27/55 (49%)
Query: 461 GPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEE 515
G L +TA + K + E E EEE+EED + EE++ S+ +EE
Sbjct: 109 GHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEE 163
Score = 32.7 bits (73), Expect = 1.4
Identities = 16/39 (41%), Positives = 24/39 (61%), Gaps = 4/39 (10%)
Query: 488 ESSSEEEEE----EDEEDEEEEESESSDSEEERAHRLAE 522
ES EEEEE E+EE+E+ + E+ DSE++ + E
Sbjct: 130 ESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEE 168
Score = 32.7 bits (73), Expect = 1.4
Identities = 39/195 (20%), Positives = 78/195 (40%), Gaps = 11/195 (5%)
Query: 617 KKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSL 676
K+ +P + DSE++E + Q +DI+K+ +K V ++ +
Sbjct: 951 KRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKP 1010
Query: 677 RDSNPEEIEIDFETLKPSTLRE---------LERYVLSCLRKKPRKPYTIKKPVGKTKEE 727
P E++ D +T +E E + L KK K + + + ++
Sbjct: 1011 CKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQ 1070
Query: 728 LALEKKRELEK-RLQ-DVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS 785
LE+K+ LEK +L+ + G ++ K +E + A++ S S ++++
Sbjct: 1071 FTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANN 1130
Query: 786 SSSSSSSSDTSDSDS 800
S+SDS
Sbjct: 1131 DQPEDLIQGCSESDS 1145
Score = 32.3 bits (72), Expect = 1.8
Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 2/38 (5%)
Query: 490 SSEEEEEED--EEDEEEEESESSDSEEERAHRLAELQE 525
S EEEEEED E+EEEE+ ++ ++++ E++E
Sbjct: 131 SEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEE 168
Score = 32.0 bits (71), Expect = 2.3
Identities = 40/163 (24%), Positives = 63/163 (38%), Gaps = 24/163 (14%)
Query: 492 EEEEEEDEEDEEEEESESSDSEEERAHRLAEL----QEQLRAVHEQLAALSQGPISKPKR 547
++EE++ + + EES ++ A +L+ L +EQLRA + AL + +
Sbjct: 2583 DKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQ 2642
Query: 548 KREKKEKK-KKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFG 606
+ K++ K KK K +A A P P PP P A PS
Sbjct: 2643 EELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAP-------------PAPPPSPPP 2689
Query: 607 PSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQ 649
P T L + P LP + EE + S K++
Sbjct: 2690 PPAVQHTGL------LSTPTLPAASQKRKREEEKDSSSKSKKK 2726
Score = 31.2 bits (69), Expect = 4.0
Identities = 12/72 (16%), Positives = 33/72 (45%)
Query: 475 KSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQL 534
+ E E + +S +EE+E +E+D++ + E + +++ A E + + +
Sbjct: 144 EEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSST 203
Query: 535 AALSQGPISKPK 546
+ + +P+
Sbjct: 204 PGRRKPRVHRPR 215
>gi|32967605 bromodomain adjacent to zinc finger domain, 1A isoform b
[Homo sapiens]
Length = 1524
Score = 73.6 bits (179), Expect = 7e-13
Identities = 65/228 (28%), Positives = 100/228 (43%), Gaps = 16/228 (7%)
Query: 255 HSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPT-----AILAPGSPASPPGSLEPK 309
HS GP L A P K++G K +T +P I S S ++ K
Sbjct: 1306 HSHGP-LQADVFVELLSPRRKRRGRKSANNTPENSPNFPNFRVIATKSSEQSRSVNIASK 1364
Query: 310 AARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYA 369
+ + R + P P + + S ++G + E L ++ EL+ +
Sbjct: 1365 LSLQESESKRRCRKRQSPEPS-PVTLGRRSSGRQGGVHE-LSAFEQLVVELVRHDDS--- 1419
Query: 370 WPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYN 429
WPF K V S + + DY+DIIK P+ L+ ++ K+ +Y+ A EF D+ LMFSNC++YN
Sbjct: 1420 WPFLKLV--SKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYN 1477
Query: 430 PPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSS 477
P + +LQ F + K+ L P V P AK S
Sbjct: 1478 PRNTSEAKAGTRLQAFFHIQAQKL---GLHVTPSNVDQVSTPPAAKKS 1522
Score = 57.4 bits (137), Expect = 5e-08
Identities = 32/97 (32%), Positives = 54/97 (55%), Gaps = 5/97 (5%)
Query: 62 PPPEVSNPKKPGRV--TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ 119
P P + GR ++L ++V++ L +H +WPF + V K+ +PDY+ IIK+
Sbjct: 1384 PSPVTLGRRSSGRQGGVHELSAFEQLVVE-LVRHDDSWPFLKLVS--KIQVPDYYDIIKK 1440
Query: 120 PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYN 156
P+ + I+ ++ Y ASE + D MF+NC+ YN
Sbjct: 1441 PIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYN 1477
Score = 33.1 bits (74), Expect = 1.0
Identities = 33/140 (23%), Positives = 52/140 (37%), Gaps = 30/140 (21%)
Query: 465 VSTAMPPGLAKSSS-ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAEL 523
+S+ P L E S E +EEE + EE+E E E + DS+EE
Sbjct: 1172 LSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQDEDDSQEEE------- 1224
Query: 524 QEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQ 583
+S PKR R + R K RG+ + +G +
Sbjct: 1225 -----------------EVSLPKRGR-----PQVRLPVKTRGKLSSSFSSRGQQQEPGRY 1262
Query: 584 PKKSKKASGSGGGSAALGPS 603
P +S++++ S+ G S
Sbjct: 1263 PSRSQQSTPKTTVSSKTGRS 1282
>gi|32967603 bromodomain adjacent to zinc finger domain, 1A isoform a
[Homo sapiens]
Length = 1556
Score = 73.6 bits (179), Expect = 7e-13
Identities = 65/228 (28%), Positives = 100/228 (43%), Gaps = 16/228 (7%)
Query: 255 HSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPT-----AILAPGSPASPPGSLEPK 309
HS GP L A P K++G K +T +P I S S ++ K
Sbjct: 1338 HSHGP-LQADVFVELLSPRRKRRGRKSANNTPENSPNFPNFRVIATKSSEQSRSVNIASK 1396
Query: 310 AARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYA 369
+ + R + P P + + S ++G + E L ++ EL+ +
Sbjct: 1397 LSLQESESKRRCRKRQSPEPS-PVTLGRRSSGRQGGVHE-LSAFEQLVVELVRHDDS--- 1451
Query: 370 WPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYN 429
WPF K V S + + DY+DIIK P+ L+ ++ K+ +Y+ A EF D+ LMFSNC++YN
Sbjct: 1452 WPFLKLV--SKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYN 1509
Query: 430 PPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSS 477
P + +LQ F + K+ L P V P AK S
Sbjct: 1510 PRNTSEAKAGTRLQAFFHIQAQKL---GLHVTPSNVDQVSTPPAAKKS 1554
Score = 57.4 bits (137), Expect = 5e-08
Identities = 32/97 (32%), Positives = 54/97 (55%), Gaps = 5/97 (5%)
Query: 62 PPPEVSNPKKPGRV--TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ 119
P P + GR ++L ++V++ L +H +WPF + V K+ +PDY+ IIK+
Sbjct: 1416 PSPVTLGRRSSGRQGGVHELSAFEQLVVE-LVRHDDSWPFLKLVS--KIQVPDYYDIIKK 1472
Query: 120 PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYN 156
P+ + I+ ++ Y ASE + D MF+NC+ YN
Sbjct: 1473 PIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYN 1509
Score = 33.1 bits (74), Expect = 1.0
Identities = 33/140 (23%), Positives = 52/140 (37%), Gaps = 30/140 (21%)
Query: 465 VSTAMPPGLAKSSS-ESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAEL 523
+S+ P L E S E +EEE + EE+E E E + DS+EE
Sbjct: 1204 LSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQDEDDSQEEE------- 1256
Query: 524 QEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQ 583
+S PKR R + R K RG+ + +G +
Sbjct: 1257 -----------------EVSLPKRGR-----PQVRLPVKTRGKLSSSFSSRGQQQEPGRY 1294
Query: 584 PKKSKKASGSGGGSAALGPS 603
P +S++++ S+ G S
Sbjct: 1295 PSRSQQSTPKTTVSSKTGRS 1314
>gi|20357588 TBP-associated factor 1 isoform 2 [Homo sapiens]
Length = 1872
Score = 73.2 bits (178), Expect = 9e-13
Identities = 86/372 (23%), Positives = 150/372 (40%), Gaps = 77/372 (20%)
Query: 356 ILKELLSKKHAAY--AWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQE 413
IL ++++K A +WPF+ PV+ + DY+ +I +PMDL T+++ + Y+ +
Sbjct: 1510 ILDNIVTQKMMAVPDSWPFHHPVNKKFVP--DYYKVIVNPMDLETIRKNISKHKYQSRES 1567
Query: 414 FAADVRLMFSNCYKYNPPDHDVVAMARKL-------------------QDVFEFRYAKMP 454
F DV L+ +N KYN P+ A+++ +D+ + A +
Sbjct: 1568 FLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALE 1627
Query: 455 D------EPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEE-----------EEE 497
+ +P+ PGP T PP L +++ S +S E E++
Sbjct: 1628 EAELESLDPMTPGPY---TPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQ 1684
Query: 498 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKK 557
++ E+ + + +D EE Q Q ++E L +S+G + E+
Sbjct: 1685 VTQEGEDGDGDLADEEEGTVQ-----QPQASVLYEDL-LMSEG--EDDEEDAGSDEEGDN 1736
Query: 558 RKAEKHRGRAGADEDDKGPRAPRPPQPK-------------KSKKASGSGGGSAALGPSG 604
+ +G+D D G RP QP+ +S + GG A+ G
Sbjct: 1737 PFSAIQLSESGSD-SDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLED 1795
Query: 605 FGPSGGSGTKL-PKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLG 663
S GS + PK T+ + GY+ EEEE +E+ Q S G +
Sbjct: 1796 SNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDE----EEEEQRS-------GPSVL 1844
Query: 664 RVVHIIQAREPS 675
VH+ + E S
Sbjct: 1845 SQVHLSEDEEDS 1856
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/215 (22%), Positives = 95/215 (44%), Gaps = 25/215 (11%)
Query: 260 PLLAVTAAPPAQPLAKKKGVKRKADTTT---PTPTAILAPGSPASPPGSLEPKAARLPPM 316
PL T APP+ P+A + + + + T I G+ L A +
Sbjct: 1280 PLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV--- 1336
Query: 317 RRESGRPIKPPRKDLPDSQQQ--------------HQSSKKGKLSEQLKHCNGILKELLS 362
R +K P++ LP +++ H+S + + ++ + + IL+ +++
Sbjct: 1337 -RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRR-TDPMVTLSSILESIIN 1394
Query: 363 K-KHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLM 421
+ +PF+ PV+A + DY+ II PMDL T++ + R Y +EF + L+
Sbjct: 1395 DMRDLPNTYPFHTPVNAKVV--KDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELI 1452
Query: 422 FSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDE 456
N YN P H + +++ + D+ + + + D+
Sbjct: 1453 VKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDK 1487
Score = 57.0 bits (136), Expect = 7e-08
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
Query: 82 LHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASEC 141
L +V + + +WPF PV+ K +PDY+K+I PMD+ TI++ + + Y +
Sbjct: 1511 LDNIVTQKMMAVPDSWPFHHPVN--KKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESF 1568
Query: 142 MQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQEL 187
+ D N + N YN P AQ + + Q + + +L
Sbjct: 1569 LDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQL 1614
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 2/73 (2%)
Query: 97 WPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYN 156
+PF PV+A + DY+KII +PMD+ T++ + Y + E + + N YN
Sbjct: 1403 YPFHTPVNAKVV--KDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYN 1460
Query: 157 KPTDDIVLMAQTL 169
P + ++Q++
Sbjct: 1461 GPKHSLTQISQSM 1473
Score = 31.6 bits (70), Expect = 3.0
Identities = 35/178 (19%), Positives = 70/178 (39%), Gaps = 11/178 (6%)
Query: 503 EEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEK 562
+EE E E R + + ++R ++ + R+ +KE+++ ++ +
Sbjct: 1173 DEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLR 1232
Query: 563 HRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKT 622
R E KGP +P + K+ G A+G + P
Sbjct: 1233 RLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHM------RTNKFCPLYYQTN 1286
Query: 623 APPALPTGYDSEEEEE-SRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDS 679
APP+ P E+EEE + + +++ +L K+ G K+ +I++ + R S
Sbjct: 1287 APPSNPVAMTEEQEEELEKTVIHNDNEELI----KVEGTKIVLGKQLIESADEVRRKS 1340
Score = 30.4 bits (67), Expect = 6.8
Identities = 26/104 (25%), Positives = 37/104 (35%), Gaps = 17/104 (16%)
Query: 407 DYRDAQEFAADVRLMFSN--------CYK-YNPPDHDVVAMARKLQDVFEFRYAKMPDEP 457
DY D E A D + C+ Y+ D+D D + MP P
Sbjct: 109 DYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDDYDA--------DCEDIDCKLMPPPP 160
Query: 458 LEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEED 501
PGP+ + SSS +S SE +E + + ED
Sbjct: 161 PPPGPMKKDKDQDSITGEKVDFSSSSDSESEMGPQEATQAESED 204
>gi|20357585 TBP-associated factor 1 isoform 1 [Homo sapiens]
Length = 1893
Score = 73.2 bits (178), Expect = 9e-13
Identities = 86/372 (23%), Positives = 150/372 (40%), Gaps = 77/372 (20%)
Query: 356 ILKELLSKKHAAY--AWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQE 413
IL ++++K A +WPF+ PV+ + DY+ +I +PMDL T+++ + Y+ +
Sbjct: 1531 ILDNIVTQKMMAVPDSWPFHHPVNKKFVP--DYYKVIVNPMDLETIRKNISKHKYQSRES 1588
Query: 414 FAADVRLMFSNCYKYNPPDHDVVAMARKL-------------------QDVFEFRYAKMP 454
F DV L+ +N KYN P+ A+++ +D+ + A +
Sbjct: 1589 FLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALE 1648
Query: 455 D------EPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEE-----------EEE 497
+ +P+ PGP T PP L +++ S +S E E++
Sbjct: 1649 EAELESLDPMTPGPY---TPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQ 1705
Query: 498 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKK 557
++ E+ + + +D EE Q Q ++E L +S+G + E+
Sbjct: 1706 VTQEGEDGDGDLADEEEGTVQ-----QPQASVLYEDL-LMSEG--EDDEEDAGSDEEGDN 1757
Query: 558 RKAEKHRGRAGADEDDKGPRAPRPPQPK-------------KSKKASGSGGGSAALGPSG 604
+ +G+D D G RP QP+ +S + GG A+ G
Sbjct: 1758 PFSAIQLSESGSD-SDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLED 1816
Query: 605 FGPSGGSGTKL-PKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLG 663
S GS + PK T+ + GY+ EEEE +E+ Q S G +
Sbjct: 1817 SNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDE----EEEEQRS-------GPSVL 1865
Query: 664 RVVHIIQAREPS 675
VH+ + E S
Sbjct: 1866 SQVHLSEDEEDS 1877
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/215 (22%), Positives = 95/215 (44%), Gaps = 25/215 (11%)
Query: 260 PLLAVTAAPPAQPLAKKKGVKRKADTTT---PTPTAILAPGSPASPPGSLEPKAARLPPM 316
PL T APP+ P+A + + + + T I G+ L A +
Sbjct: 1301 PLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV--- 1357
Query: 317 RRESGRPIKPPRKDLPDSQQQ--------------HQSSKKGKLSEQLKHCNGILKELLS 362
R +K P++ LP +++ H+S + + ++ + + IL+ +++
Sbjct: 1358 -RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRR-TDPMVTLSSILESIIN 1415
Query: 363 K-KHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLM 421
+ +PF+ PV+A + DY+ II PMDL T++ + R Y +EF + L+
Sbjct: 1416 DMRDLPNTYPFHTPVNAKVV--KDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELI 1473
Query: 422 FSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDE 456
N YN P H + +++ + D+ + + + D+
Sbjct: 1474 VKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDK 1508
Score = 57.0 bits (136), Expect = 7e-08
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
Query: 82 LHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASEC 141
L +V + + +WPF PV+ K +PDY+K+I PMD+ TI++ + + Y +
Sbjct: 1532 LDNIVTQKMMAVPDSWPFHHPVN--KKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESF 1589
Query: 142 MQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQEL 187
+ D N + N YN P AQ + + Q + + +L
Sbjct: 1590 LDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQL 1635
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 2/73 (2%)
Query: 97 WPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYN 156
+PF PV+A + DY+KII +PMD+ T++ + Y + E + + N YN
Sbjct: 1424 YPFHTPVNAKVV--KDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYN 1481
Query: 157 KPTDDIVLMAQTL 169
P + ++Q++
Sbjct: 1482 GPKHSLTQISQSM 1494
Score = 31.6 bits (70), Expect = 3.0
Identities = 35/178 (19%), Positives = 70/178 (39%), Gaps = 11/178 (6%)
Query: 503 EEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEK 562
+EE E E R + + ++R ++ + R+ +KE+++ ++ +
Sbjct: 1194 DEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLR 1253
Query: 563 HRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKT 622
R E KGP +P + K+ G A+G + P
Sbjct: 1254 RLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHM------RTNKFCPLYYQTN 1307
Query: 623 APPALPTGYDSEEEEE-SRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDS 679
APP+ P E+EEE + + +++ +L K+ G K+ +I++ + R S
Sbjct: 1308 APPSNPVAMTEEQEEELEKTVIHNDNEELI----KVEGTKIVLGKQLIESADEVRRKS 1361
>gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo
sapiens]
Length = 1483
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 23/172 (13%)
Query: 302 PPGSLEPKAARLPPMRRESGRPIKPP---RKDLPDSQ------------QQHQSSKKGKL 346
P ++ K + +PP R RP K P R+ P + Q +SS++ L
Sbjct: 1284 PRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSL 1343
Query: 347 SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENR 406
+L+ C IL +++ + ++WPF +PV DY+D+I HPMD TV+ K
Sbjct: 1344 --ELQKCEEILHKIVKYR---FSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCG 1396
Query: 407 DYRDAQEFAADVRLMFSNCYKYN-PPDHDVVAMARKLQDVFEFRYAKMPDEP 457
YR QEF D++ +F+N YN H + M + Q + + +P P
Sbjct: 1397 SYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHP 1448
Score = 56.2 bits (134), Expect = 1e-07
Identities = 27/77 (35%), Positives = 43/77 (55%), Gaps = 7/77 (9%)
Query: 80 QYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAAS 139
+ LHK+V K++F+WPFR+PV + DY+ +I PMD T++ + Y +
Sbjct: 1350 EILHKIV-----KYRFSWPFREPVTRDEA--EDYYDVITHPMDFQTVQNKCSCGSYRSVQ 1402
Query: 140 ECMQDFNTMFTNCYIYN 156
E + D +FTN +YN
Sbjct: 1403 EFLTDMKQVFTNAEVYN 1419
Score = 43.5 bits (101), Expect = 8e-04
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 6/95 (6%)
Query: 468 AMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQL 527
A P A+ +S + S S E++E DEE+EEEEE E + E RL ++ +
Sbjct: 1230 ACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRP-RKTI 1288
Query: 528 RAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEK 562
R H + P ++ R+ KK +R K
Sbjct: 1289 RGKHSVIP-----PAARSGRRPGKKPHSTRRSQPK 1318
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 452 KMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESE 508
++PD + +TA ++ +E S+ E S + S+EEEEE+EE+EEEE+ E
Sbjct: 1220 EVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYE 1276
>gi|148612882 cat eye syndrome chromosome region, candidate 2 [Homo
sapiens]
Length = 1484
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/138 (33%), Positives = 70/138 (50%), Gaps = 12/138 (8%)
Query: 38 LLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKV--VMKALWKHQF 95
LL +G E P P L N P E K + + ++KV V+KA H+
Sbjct: 404 LLAQGKELP-----PELSHLDPNSPMREEKKTKDLFELDDDFTAMYKVLDVVKA---HKD 455
Query: 96 AWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIY 155
+WPF +PVD + P+Y++IIK PMD+ +++++L Y E + D TMF NC Y
Sbjct: 456 SWPFLEPVD--ESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKY 513
Query: 156 NKPTDDIVLMAQTLEKIF 173
N + + M+ LE+ F
Sbjct: 514 NGESSEYTKMSDNLERCF 531
Score = 71.2 bits (173), Expect = 3e-12
Identities = 81/358 (22%), Positives = 128/358 (35%), Gaps = 75/358 (20%)
Query: 321 GRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASA 380
G+ + P L + + K L E + K L K +WPF +PVD S
Sbjct: 408 GKELPPELSHLDPNSPMREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESY 467
Query: 381 LGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMAR 440
+Y+ IIK PMD+S++++K+ Y +EF D++ MF NC KYN +
Sbjct: 468 AP--NYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSE------ 519
Query: 441 KLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEE 500
Y KM D L + + + E +EE E
Sbjct: 520 ---------YTKMSD----------------NLERCFHRAMMKHFPGEDGDTDEEFWIRE 554
Query: 501 DEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKA 560
DE+ E+ S +H ++ + +Q + G P R
Sbjct: 555 DEKREKRRSRAGRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLPPTR------------- 601
Query: 561 EKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSG-----GGSAALG----------PSGF 605
RA + DD+ + +PP+ + G GG+ + P F
Sbjct: 602 -----RAPSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQMRPAVPGTF 656
Query: 606 GPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLG 663
GP GS AT +P + E ++ +P + Q + IN L G +LG
Sbjct: 657 GPLRGS-----DPATLYGSSGVPEPHPGEPVQQRQPFT----MQPPVGINSLRGPRLG 705
>gi|153791535 general control of amino acid synthesis 5-like 2 [Homo
sapiens]
Length = 837
Score = 71.2 bits (173), Expect = 3e-12
Identities = 49/179 (27%), Positives = 83/179 (46%), Gaps = 20/179 (11%)
Query: 273 LAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPI-KPPRKDL 331
+ K+K + +K + PG G + +P +R +P+ K K+L
Sbjct: 668 IKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKEL 727
Query: 332 PDSQQQHQSSKKGKLSEQLKHCNGILKELLSK-KHAAYAWPFYKPVDASALGLHDYHDII 390
D Q + + LK LL++ K AWPF +PV S DY+++I
Sbjct: 728 KDPDQLYTT----------------LKNLLAQIKSHPSAWPFMEPVKKSEAP--DYYEVI 769
Query: 391 KHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFR 449
+ P+DL T+ ++ +R Y + F AD++ + +NC +YNPPD + A L+ F F+
Sbjct: 770 RFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFK 828
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/141 (31%), Positives = 64/141 (45%), Gaps = 5/141 (3%)
Query: 37 SLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFA 96
S EG + SVP ++ T P E K +QL K ++ + H A
Sbjct: 694 SCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKD---PDQLYTTLKNLLAQIKSHPSA 750
Query: 97 WPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYN 156
WPF +PV K PDY+++I+ P+D+ T+ RL + YY + D + NC YN
Sbjct: 751 WPFMEPVK--KSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYN 808
Query: 157 KPTDDIVLMAQTLEKIFLQKV 177
P + A LEK F K+
Sbjct: 809 PPDSEYCRCASALEKFFYFKL 829
>gi|209977097 tripartite motif-containing 66 [Homo sapiens]
Length = 1216
Score = 70.5 bits (171), Expect = 6e-12
Identities = 48/122 (39%), Positives = 64/122 (52%), Gaps = 19/122 (15%)
Query: 371 PFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRD---YRDAQEFAADVRLMFSNCYK 427
PF++PV S L H Y+ IIK PMDLS ++RK++ +D Y +E +DVRLMF NC K
Sbjct: 1065 PFHEPV--SPLARH-YYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAK 1121
Query: 428 YNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSS 487
+N PD +V R L+ FE ++ E P +S SEE SS
Sbjct: 1122 FNYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFAQP-------------RQEDSDSEEVSS 1168
Query: 488 ES 489
ES
Sbjct: 1169 ES 1170
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/105 (29%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 72 PGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLE 131
PG + K+V+ +L + + PF +PV + Y++IIK+PMD+ I+R+L+
Sbjct: 1040 PGLSMYDQKKCEKLVL-SLCCNNLSLPFHEPVSPLAR---HYYQIIKRPMDLSIIRRKLQ 1095
Query: 132 NN---YYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIF 173
+Y E + D MF NC +N P ++ + LE F
Sbjct: 1096 KKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFF 1140
>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
sapiens]
Length = 2168
Score = 70.1 bits (170), Expect = 8e-12
Identities = 41/118 (34%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
Query: 335 QQQHQSSKKGKL--SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKH 392
Q+ S KK K S+ L C+ IL E+ + + A WPF PV+ + Y +IK
Sbjct: 2049 QESFTSVKKPKRDDSKDLALCSMILTEMETHEDA---WPFLLPVNLKLVP--GYKKVIKK 2103
Query: 393 PMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRY 450
PMD ST++ K+ + Y + + FA DVRL+F NC +N D D+ ++ FE ++
Sbjct: 2104 PMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKW 2161
Score = 62.8 bits (151), Expect = 1e-09
Identities = 36/107 (33%), Positives = 56/107 (52%), Gaps = 2/107 (1%)
Query: 70 KKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRR 129
KKP R ++ L +++ + H+ AWPF PV+ +KL +P Y K+IK+PMD TI+ +
Sbjct: 2056 KKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVN-LKL-VPGYKKVIKKPMDFSTIREK 2113
Query: 130 LENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQK 176
L + Y D +F NC +N+ DI + K F +K
Sbjct: 2114 LSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK 2160
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 11/84 (13%)
Query: 476 SSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLA 535
+SS++SSE SS S + EE+E+EED+ EESE DS+ E A H+
Sbjct: 251 TSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSES-----------EAQHKSNN 299
Query: 536 ALSQGPISKPKRKREKKEKKKKRK 559
+ IS PK +K +K + K
Sbjct: 300 QVLLHGISDPKADGQKATEKAQEK 323
Score = 43.9 bits (102), Expect = 6e-04
Identities = 18/36 (50%), Positives = 26/36 (72%)
Query: 480 SSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEE 515
S E S+E E++EEEDEED+E++ES+ S SE +
Sbjct: 601 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESD 636
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/195 (20%), Positives = 76/195 (38%), Gaps = 19/195 (9%)
Query: 476 SSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLA 535
+ S+ S + S +S+ +EEE+++EEDEE++E + SD + + +E +
Sbjct: 594 TDSDIPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTE--------G 645
Query: 536 ALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGG 595
+ + K + + + + +K + ++ + P+ KA GS
Sbjct: 646 SEEEDDDDKDQDESDSDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAP 705
Query: 596 G---SAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSL 652
S + P+ G S + T P T ++E E P+ Y +R+
Sbjct: 706 AALCSESQSPAFLGTSSSTLTSSPHSGTSKRRRV------TDERELRIPLEYGWQRETR- 758
Query: 653 DINKLPGEKLGRVVH 667
I G G V +
Sbjct: 759 -IRNFGGRLQGEVAY 772
Score = 40.8 bits (94), Expect = 0.005
Identities = 17/55 (30%), Positives = 35/55 (63%)
Query: 475 KSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRA 529
+S S +S+SES +E EEED++D++++ES+S E+ + +L + +++
Sbjct: 627 ESDDSQSESDSNSESDTEGSEEEDDDDKDQDESDSDTEGEKTSMKLNKTTSSVKS 681
Score = 37.0 bits (84), Expect = 0.073
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 471 PGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESES-SDSEEE 515
P S + EE E EE++E+DE D+ + ES+S S+S+ E
Sbjct: 599 PSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTE 644
Score = 36.6 bits (83), Expect = 0.095
Identities = 18/78 (23%), Positives = 39/78 (50%), Gaps = 8/78 (10%)
Query: 464 PVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESE--------SSDSEEE 515
P+ T P + S + + S+++ +ED+EDEE++E + + E +
Sbjct: 1280 PLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEEDKEDKKGKKTDICEDEDEGD 1339
Query: 516 RAHRLAELQEQLRAVHEQ 533
+A + EL++Q+ + +Q
Sbjct: 1340 QAASVEELEKQIEKLSKQ 1357
Score = 33.5 bits (75), Expect = 0.80
Identities = 26/78 (33%), Positives = 35/78 (44%), Gaps = 14/78 (17%)
Query: 722 GKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSS 781
G K K + L+ R+ + KKP KKA E + +S S S +SS
Sbjct: 208 GNRKCNQEQSKNQPLDARVDKIKD-----KKPRKKAMESSSNSD---------SDSGTSS 253
Query: 782 DSSSSSSSSSSSDTSDSD 799
D+SS SSS SD + D
Sbjct: 254 DTSSEGISSSDSDDLEED 271
>gi|74027251 tripartite motif-containing 33 protein isoform beta [Homo
sapiens]
Length = 1110
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/206 (28%), Positives = 90/206 (43%), Gaps = 38/206 (18%)
Query: 322 RPIKPPRKDLPDSQQQHQSSKKGKLSEQL-----KHCNGILKELLSKKHAAYAWPFYKPV 376
R I P + QH SKKGK ++ L + C +L L + + F +PV
Sbjct: 932 RDIGKPEVEYDCDNLQH--SKKGKTAQGLSPVDQRKCERLLLYLYCHELSI---EFQEPV 986
Query: 377 DASALGLHDYHDIIKHPMDLSTVKRKMENRD---YRDAQEFAADVRLMFSNCYKYNPPDH 433
AS + +Y+ IIK PMDLSTVK+K++ + Y+ +F ADVRL+F NC ++N D
Sbjct: 987 PAS---IPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEADS 1043
Query: 434 DVVAMARKLQDVFEFRYAKM-PDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSE 492
+V + + FE + ++ D P P E E
Sbjct: 1044 EVAQAGKAVALYFEDKLTEIYSDRTFAPLP---------------------EFEQEEDDG 1082
Query: 493 EEEEEDEEDEEEEESESSDSEEERAH 518
E E+ +ED + + S+E H
Sbjct: 1083 EVTEDSDEDFIQPRRKRLKSDERPVH 1108
Score = 56.6 bits (135), Expect = 9e-08
Identities = 31/109 (28%), Positives = 59/109 (54%), Gaps = 15/109 (13%)
Query: 90 LWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLE---NNYYWAASECMQDFN 146
L+ H+ + F++PV A +P+Y+KIIK+PMD+ T+K++L+ + +Y + + D
Sbjct: 973 LYCHELSIEFQEPVPA---SIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVR 1029
Query: 147 TMFTNCYIYNKPTDDIVLMAQTLEKIFLQKV---------ASMPQEEQE 186
+F NC +N+ ++ + + F K+ A +P+ EQE
Sbjct: 1030 LIFKNCERFNEADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQE 1078
>gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo
sapiens]
Length = 1905
Score = 68.6 bits (166), Expect = 2e-11
Identities = 44/122 (36%), Positives = 66/122 (54%), Gaps = 10/122 (8%)
Query: 334 SQQQHQSSKKGKLSEQLKH-----CNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHD 388
S++ SK+ +LS + H C IL E+ S H A AWPF +PV+ + Y
Sbjct: 1778 SEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMES--HDA-AWPFLEPVNPRLVS--GYRR 1832
Query: 389 IIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEF 448
IIK+PMD ST++ ++ Y ++EFAAD L+F NC +N D +V ++ FE
Sbjct: 1833 IIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFES 1892
Query: 449 RY 450
R+
Sbjct: 1893 RW 1894
Score = 53.9 bits (128), Expect = 6e-07
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Query: 84 KVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQ 143
++++ + H AWPF +PV+ + Y +IIK PMD T++ RL Y ++ E
Sbjct: 1803 EIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860
Query: 144 DFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQ 185
D +F NC +N+ ++ + + F + Q +Q
Sbjct: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
Score = 30.8 bits (68), Expect = 5.2
Identities = 25/99 (25%), Positives = 55/99 (55%), Gaps = 9/99 (9%)
Query: 498 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHE--QLAALSQGPISKPKRKRE----- 550
D ++ E++ + +EE++A ++A+ ++++R + + QG ++ KRK+E
Sbjct: 689 DNRPLKKLEAQETLNEEDKA-KIAKSKKKMRQKVQRGECQTTIQGQ-ARNKRKQETKSLK 746
Query: 551 KKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKK 589
+KE KKK KAEK +G+ ++ + + + + K +K
Sbjct: 747 QKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEK 785
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 67.4 bits (163), Expect = 5e-11
Identities = 62/220 (28%), Positives = 91/220 (41%), Gaps = 39/220 (17%)
Query: 454 PDE-PLEPGPLPVSTAMPP----------------GLAKSSSESSSEE--------SSSE 488
P+E P PGPLP PP G + EE SS E
Sbjct: 829 PEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDE 888
Query: 489 SSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRK 548
EEEEEE+EE+EEEEE E + EEE E +E+ E+ +G + + + +
Sbjct: 889 EEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEE 948
Query: 549 REKKEKKKKRKAEK-HRGRAGADEDDKGPRAPR------PPQ--PKKSKKASGSGGGSAA 599
+++E+++ + E G AG + ++ P P PP+ PK + G
Sbjct: 949 EDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLE 1008
Query: 600 LGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEES 639
+ G G+ T A AP ALP+ + E E ES
Sbjct: 1009 VEEPGTEEERGADT-----APTLAPEALPSQGEVEREGES 1043
>gi|34452709 bromodomain containing 8 isoform 3 [Homo sapiens]
Length = 757
Score = 67.4 bits (163), Expect = 5e-11
Identities = 40/82 (48%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 368 YAWPFYKPV-DASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY 426
YA F +PV D A G YH I++ PMDLST+K+ +EN R EF D+ LMF N
Sbjct: 622 YANVFLQPVTDDIAPG---YHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAV 678
Query: 427 KYNPPDHDVVAMARKLQ-DVFE 447
YN DHDV MA ++Q DV E
Sbjct: 679 MYNSSDHDVYHMAVEMQRDVLE 700
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/142 (28%), Positives = 72/142 (50%), Gaps = 14/142 (9%)
Query: 78 QLQYLHKVVMKALWK----HQFAWPFRQPV-DAVKLGLPDYHKIIKQPMDMGTIKRRLEN 132
Q Q + K + +W+ H++A F QPV D + P YH I+++PMD+ TIK+ +EN
Sbjct: 601 QAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIA---PGYHSIVQRPMDLSTIKKNIEN 657
Query: 133 NYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIP 192
+ +E +D MF N +YN D+ MA +++ L+++ +Q L +
Sbjct: 658 GLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQI------QQFLATQLI 711
Query: 193 KNSHKKGAKLAALQGSVTSAHQ 214
+ + G +L+G ++ Q
Sbjct: 712 MQTSESGISAKSLRGRDSTRKQ 733
>gi|34452707 bromodomain containing 8 isoform 2 [Homo sapiens]
Length = 1235
Score = 67.4 bits (163), Expect = 5e-11
Identities = 40/82 (48%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 368 YAWPFYKPV-DASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY 426
YA F +PV D A G YH I++ PMDLST+K+ +EN R EF D+ LMF N
Sbjct: 728 YANVFLQPVTDDIAPG---YHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAV 784
Query: 427 KYNPPDHDVVAMARKLQ-DVFE 447
YN DHDV MA ++Q DV E
Sbjct: 785 MYNSSDHDVYHMAVEMQRDVLE 806
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/142 (28%), Positives = 72/142 (50%), Gaps = 14/142 (9%)
Query: 78 QLQYLHKVVMKALWK----HQFAWPFRQPV-DAVKLGLPDYHKIIKQPMDMGTIKRRLEN 132
Q Q + K + +W+ H++A F QPV D + P YH I+++PMD+ TIK+ +EN
Sbjct: 707 QAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIA---PGYHSIVQRPMDLSTIKKNIEN 763
Query: 133 NYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIP 192
+ +E +D MF N +YN D+ MA +++ L+++ +Q L +
Sbjct: 764 GLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQI------QQFLATQLI 817
Query: 193 KNSHKKGAKLAALQGSVTSAHQ 214
+ + G +L+G ++ Q
Sbjct: 818 MQTSESGISAKSLRGRDSTRKQ 839
Score = 57.0 bits (136), Expect = 7e-08
Identities = 40/123 (32%), Positives = 55/123 (44%), Gaps = 15/123 (12%)
Query: 331 LPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAW----------PFYKPVDASA 380
L D+ H +S K L + + LL KK W PF KPV S
Sbjct: 1080 LVDTLFSHATSSK---LTDLSQDDPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPV--SE 1134
Query: 381 LGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMAR 440
Y D++K PMDL+++KR + R +F D+ LMF N YN DH V MA
Sbjct: 1135 RQAPGYKDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAV 1194
Query: 441 KLQ 443
+++
Sbjct: 1195 EMR 1197
Score = 52.0 bits (123), Expect = 2e-06
Identities = 28/100 (28%), Positives = 51/100 (51%), Gaps = 6/100 (6%)
Query: 82 LHKVVMKALWK----HQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWA 137
L K + +WK H+F+ PF +PV + P Y ++K+PMD+ ++KR L
Sbjct: 1107 LFKKTLLPVWKMIASHRFSSPFLKPVSERQA--PGYKDVVKRPMDLTSLKRNLSKGRIRT 1164
Query: 138 ASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKV 177
++ ++D MF N +YN + MA + + L+++
Sbjct: 1165 MAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRREVLEQI 1204
>gi|34452705 bromodomain containing 8 isoform 1 [Homo sapiens]
Length = 951
Score = 67.4 bits (163), Expect = 5e-11
Identities = 40/82 (48%), Positives = 49/82 (59%), Gaps = 5/82 (6%)
Query: 368 YAWPFYKPV-DASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY 426
YA F +PV D A G YH I++ PMDLST+K+ +EN R EF D+ LMF N
Sbjct: 801 YANVFLQPVTDDIAPG---YHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAV 857
Query: 427 KYNPPDHDVVAMARKLQ-DVFE 447
YN DHDV MA ++Q DV E
Sbjct: 858 MYNSSDHDVYHMAVEMQRDVLE 879
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/142 (28%), Positives = 72/142 (50%), Gaps = 14/142 (9%)
Query: 78 QLQYLHKVVMKALWK----HQFAWPFRQPV-DAVKLGLPDYHKIIKQPMDMGTIKRRLEN 132
Q Q + K + +W+ H++A F QPV D + P YH I+++PMD+ TIK+ +EN
Sbjct: 780 QAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIA---PGYHSIVQRPMDLSTIKKNIEN 836
Query: 133 NYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIP 192
+ +E +D MF N +YN D+ MA +++ L+++ +Q L +
Sbjct: 837 GLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQI------QQFLATQLI 890
Query: 193 KNSHKKGAKLAALQGSVTSAHQ 214
+ + G +L+G ++ Q
Sbjct: 891 MQTSESGISAKSLRGRDSTRKQ 912
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 67.0 bits (162), Expect = 7e-11
Identities = 142/629 (22%), Positives = 224/629 (35%), Gaps = 140/629 (22%)
Query: 284 DTTTPTPTAILAPGSPAS---PPGSLEPKA--------ARLPPMRRESGRPIKPPR-KDL 331
D TP + ++AP P S PP SL K+ A + PM + P + P K L
Sbjct: 255 DKETPQDS-LVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPL 313
Query: 332 PDSQQQHQSSK-------KGKLSEQLKHCNGILKELLSK---------KHAAYAWPFYKP 375
P+ +Q K K KL++ LK + +++ S K ++WP P
Sbjct: 314 PEDYRQQTFEKTDLKVPAKAKLTK-LKMPSQSVEQTYSNEVHCVEEILKEMTHSWP--PP 370
Query: 376 VDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDV 435
+ A I P K +D + + + ++ ++
Sbjct: 371 LTA-----------IHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGT 419
Query: 436 VAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEE 495
+M L+D + ++ D P P S+A PP +S E + SS + SE
Sbjct: 420 SSM---LEDDLQLSDSEDSDSEQTPEKPPSSSA-PPSAPQSLPEPVASAHSSSAESESTS 475
Query: 496 EEDEEDEEEEESESSDSEEERAHRLA------------ELQEQLRAVHEQLAALSQGPIS 543
+ D + E ES SSDSEE +L L V Q AA +GP S
Sbjct: 476 DSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKV-SQPAAPPEGPRS 534
Query: 544 --KPKRKREKKEKKKKRKAEKHRGRAG--ADEDDKGPRAP------------------RP 581
P+R E K +++H K PRAP P
Sbjct: 535 TEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEP 594
Query: 582 P--------QPKKSKKASGSGGGSAAL------GPSGFGPSGGSGTKLPKKATKTAP--- 624
P QPKK KAS G +L G +G + PK TK P
Sbjct: 595 PQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAA 654
Query: 625 ------PALPTGYDSEEEEESRP-----MSYDEKRQLSLDINKLP--------------- 658
PA+P + ++ + S P +S E + +++ ++ P
Sbjct: 655 ASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVE-DRTPEHFALVPLTESQGPP 713
Query: 659 ----GEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRE-------LERYVLSCL 707
G + + +E S +D P + D + L P LR+ + + L L
Sbjct: 714 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLR-DTKLLSP--LRDTPPPQSLMVKITLDLL 770
Query: 708 RKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQ 767
+ P+ P + ++ KK EKR D S +L +K + + + +
Sbjct: 771 SRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLE 830
Query: 768 QVAVSRLSASSSSSDSSSSSSSSSSSDTS 796
+ S+ S+SSSS SS + S S S
Sbjct: 831 KEIKSQSSSSSSSHKESSKTKPSRPSSQS 859
Score = 38.5 bits (88), Expect = 0.025
Identities = 41/194 (21%), Positives = 75/194 (38%), Gaps = 21/194 (10%)
Query: 470 PPGLAKSSSESSSEESSSESSSEEEEEEDEEDEE-----EEESESSDSEEERAHRLAELQ 524
PP K SSE S +SSS+ + + + E + + + E+E +S S +H+ +
Sbjct: 791 PPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKT 850
Query: 525 EQLR--AVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPP 582
+ R + + L P+S +K K K+ R+ G+ +
Sbjct: 851 KPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDS 910
Query: 583 QPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPM 642
K ++ G G S++ G SG + P P+LP G + +P
Sbjct: 911 SIPKQRRVEGKGSRSSS---EHKGSSGDTANPFP-------VPSLPNG----NSKPGKPQ 956
Query: 643 SYDEKRQLSLDINK 656
+K+Q L + +
Sbjct: 957 VKFDKQQADLHMRE 970
Score = 36.6 bits (83), Expect = 0.095
Identities = 21/60 (35%), Positives = 29/60 (48%)
Query: 741 QDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDS 800
+D + K P A S + VA + S++ S S S S SSS S S++S SDS
Sbjct: 433 EDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDS 492
Score = 33.9 bits (76), Expect = 0.61
Identities = 21/65 (32%), Positives = 35/65 (53%)
Query: 736 LEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDT 795
LE LQ + + +++ P+K + SA Q ++++ SSS S S+S S SS
Sbjct: 423 LEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSD 482
Query: 796 SDSDS 800
S+S+S
Sbjct: 483 SESES 487
Score = 30.0 bits (66), Expect = 8.9
Identities = 15/51 (29%), Positives = 26/51 (50%)
Query: 749 STKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSD 799
S+ PP E ++ + + ++S S SS S S SSSSD+ +++
Sbjct: 446 SSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENE 496
>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
[Homo sapiens]
Length = 1050
Score = 65.9 bits (159), Expect = 1e-10
Identities = 42/142 (29%), Positives = 67/142 (47%), Gaps = 23/142 (16%)
Query: 377 DASALGLHDYHDIIKHPMDLSTVKRKMEN--RDYRDAQEFAADVRLMFSNCYKYNPPDHD 434
D L + DY+ IIK+PMDLST+K++++ Y ++F AD RL+F NC ++N PD +
Sbjct: 926 DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSE 985
Query: 435 VVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEE 494
V KL++ FE + E P P E +ES +
Sbjct: 986 VANAGIKLENYFEELLKNLYPEKRFPKP---------------------EFRNESEDNKF 1024
Query: 495 EEEDEEDEEEEESESSDSEEER 516
++ ++D + + S EER
Sbjct: 1025 SDDSDDDFVQPRKKRLKSIEER 1046
Score = 65.5 bits (158), Expect = 2e-10
Identities = 34/98 (34%), Positives = 57/98 (58%), Gaps = 5/98 (5%)
Query: 90 LWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNY--YWAASECMQDFNT 147
L+ H+ + F+ PV L +PDY+KIIK PMD+ TIK+RL+ +Y Y + + DF
Sbjct: 915 LYCHEMSLAFQDPVP---LTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRL 971
Query: 148 MFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQ 185
+F NC +N+P ++ LE F + + ++ E++
Sbjct: 972 IFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKR 1009
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,113,033
Number of Sequences: 37866
Number of extensions: 2295359
Number of successful extensions: 71219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1293
Number of HSP's successfully gapped in prelim test: 1504
Number of HSP's that attempted gapping in prelim test: 25225
Number of HSP's gapped (non-prelim): 25200
length of query: 801
length of database: 18,247,518
effective HSP length: 110
effective length of query: 691
effective length of database: 14,082,258
effective search space: 9730840278
effective search space used: 9730840278
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.