Search of human proteins with 163965441

Search of human proteins with 163965441

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|163965441 hypothetical protein LOC149499 [Homo sapiens]
         (559 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|163965441 hypothetical protein LOC149499 [Homo sapiens]           1108   0.0  
gi|118918429 NOD3 protein [Homo sapiens]                               68   2e-11
gi|11545912 nucleotide-binding oligomerization domain containing...    64   3e-10
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]    55   2e-07
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ...    52   2e-06
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ...    52   2e-06
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ...    52   2e-06
gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]    50   4e-06
gi|168986655 hypothetical protein LOC145497 [Homo sapiens]             50   4e-06
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...    49   1e-05
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]      49   1e-05
gi|5174617 nucleotide-binding oligomerization domain containing ...    48   2e-05
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]              47   6e-05
gi|21450705 leucine rich repeat containing 45 [Homo sapiens]           47   6e-05
gi|23503285 leucine rich repeat containing 34 [Homo sapiens]           46   8e-05
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo...    46   8e-05
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]           46   1e-04
gi|156938336 class II transactivator [Homo sapiens]                    45   2e-04
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]      44   4e-04
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]              43   9e-04
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...    41   0.003
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...    41   0.003
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...    41   0.003

>gi|163965441 hypothetical protein LOC149499 [Homo sapiens]
          Length = 559

 Score = 1108 bits (2867), Expect = 0.0
 Identities = 559/559 (100%), Positives = 559/559 (100%)

Query: 1   MSSEQSAPGASPRAPRPGTQKSSGAVTKKGERAAKEKPATVLPPVGEEEPKSPEEYQCSG 60
           MSSEQSAPGASPRAPRPGTQKSSGAVTKKGERAAKEKPATVLPPVGEEEPKSPEEYQCSG
Sbjct: 1   MSSEQSAPGASPRAPRPGTQKSSGAVTKKGERAAKEKPATVLPPVGEEEPKSPEEYQCSG 60

Query: 61  VLETDFAELCTRWGYTDFPKVVNRPRPHPPFVPSASLSEKATLDDPRLSGSCSLNSLESK 120
           VLETDFAELCTRWGYTDFPKVVNRPRPHPPFVPSASLSEKATLDDPRLSGSCSLNSLESK
Sbjct: 61  VLETDFAELCTRWGYTDFPKVVNRPRPHPPFVPSASLSEKATLDDPRLSGSCSLNSLESK 120

Query: 121 YVFFRPTIQVELEQEDSKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTD 180
           YVFFRPTIQVELEQEDSKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTD
Sbjct: 121 YVFFRPTIQVELEQEDSKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTD 180

Query: 181 KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLL 240
           KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLL
Sbjct: 181 KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLL 240

Query: 241 GQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 300
           GQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL
Sbjct: 241 GQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 300

Query: 301 AEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVD 360
           AEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVD
Sbjct: 301 AEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVD 360

Query: 361 KTDKTQTMKTPKGLGKKKEKSWELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQ 420
           KTDKTQTMKTPKGLGKKKEKSWELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQ
Sbjct: 361 KTDKTQTMKTPKGLGKKKEKSWELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQ 420

Query: 421 KPSRAKGIKIGSREKRSILLESELVVEATEVVNPLLEPVEHRDGKVFMPGNKVLLHLNLI 480
           KPSRAKGIKIGSREKRSILLESELVVEATEVVNPLLEPVEHRDGKVFMPGNKVLLHLNLI
Sbjct: 421 KPSRAKGIKIGSREKRSILLESELVVEATEVVNPLLEPVEHRDGKVFMPGNKVLLHLNLI 480

Query: 481 RNRITEVGLEGFLATVQYQMQFSKAKSASKGPVGLLWLSLAKNCFAPQCPAYAIIQELML 540
           RNRITEVGLEGFLATVQYQMQFSKAKSASKGPVGLLWLSLAKNCFAPQCPAYAIIQELML
Sbjct: 481 RNRITEVGLEGFLATVQYQMQFSKAKSASKGPVGLLWLSLAKNCFAPQCPAYAIIQELML 540

Query: 541 PRDPIKAKLREDEAMAFFP 559
           PRDPIKAKLREDEAMAFFP
Sbjct: 541 PRDPIKAKLREDEAMAFFP 559


>gi|118918429 NOD3 protein [Homo sapiens]
          Length = 1065

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 53/152 (34%), Positives = 78/152 (51%), Gaps = 16/152 (10%)

Query: 169 QAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGN----PLPEQSYHKLMALDSTIAH 224
           Q  NL  + L+   L + +  L  C    RK+ L+ N    P+ E     L   D  I  
Sbjct: 616 QEANL-SLSLSQGVLQSLLPQLLYC----RKLRLDTNQFQDPVMELLGSVLSGKDCRIQK 670

Query: 225 LSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLW 284
           +SL  N I ++GA+ L ++L      NR+L SL+L  N IG +GA  +AD L++NR+L  
Sbjct: 671 ISLAENQISNKGAKALARSLLV----NRSLTSLDLRGNSIGPQGAKALADALKINRTLTS 726

Query: 285 LSLAHNRIQDKGALKLAEVL---RAFELTHTE 313
           LSL  N ++D GA  +AE L   R   + H +
Sbjct: 727 LSLQGNTVRDDGARSMAEALASNRTLSMLHLQ 758



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 50/142 (35%), Positives = 77/142 (54%), Gaps = 8/142 (5%)

Query: 167 QLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL---MALDSTIA 223
           ++Q I+L +  +++K        L L + +L  + L GN +  Q    L   + ++ T+ 
Sbjct: 667 RIQKISLAENQISNKGAKALARSL-LVNRSLTSLDLRGNSIGPQGAKALADALKINRTLT 725

Query: 224 HLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLL 283
            LSL+ N + D GA+ + +AL++    NRTL  L+L  N IG  GA  +AD L+ NRSL 
Sbjct: 726 SLSLQGNTVRDDGARSMAEALAS----NRTLSMLHLQKNSIGPMGAQRMADALKQNRSLK 781

Query: 284 WLSLAHNRIQDKGALKLAEVLR 305
            L  + N I D GA  LAE L+
Sbjct: 782 ELMFSSNSIGDGGAKALAEALK 803



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 50/174 (28%), Positives = 86/174 (49%), Gaps = 8/174 (4%)

Query: 135 EDSKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCS 194
           + ++S+KE+      + +      ++ L     L++++L    ++D  +   +  L   +
Sbjct: 775 KQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGAL-CTN 833

Query: 195 STLRKVSLEGNPL-PE--QSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCN 251
            TL  +SL  N + PE  Q+    +  +ST+ +L L  N + D+GA+ +  A+      N
Sbjct: 834 QTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRE----N 889

Query: 252 RTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
           RTL SL+L +N I    A  +   L+LNRSL  L L  N I D GA  +A  L+
Sbjct: 890 RTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK 943



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 45/117 (38%), Positives = 60/117 (51%), Gaps = 8/117 (6%)

Query: 192 LCS-STLRKVSLEGNPLPEQSYHKLMAL---DSTIAHLSLRNNNIDDRGAQLLGQALSTL 247
           LC+ STL+ + L  N L +Q    +      + T+  L L+ N I    AQ LGQAL   
Sbjct: 858 LCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQL- 916

Query: 248 HSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
              NR+L SL+L  N IGD+GA  +A  L++N +L  L L    I   GA  L E L
Sbjct: 917 ---NRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEAL 970



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 47/173 (27%), Positives = 79/173 (45%), Gaps = 8/173 (4%)

Query: 137 SKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSST 196
           ++S+  + +RG  +  +     +  L     L +++L    + D    +  E L   + T
Sbjct: 693 NRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALA-SNRT 751

Query: 197 LRKVSLEGN---PLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRT 253
           L  + L+ N   P+  Q     +  + ++  L   +N+I D GA+ L +AL      N+ 
Sbjct: 752 LSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKV----NQG 807

Query: 254 LVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
           L SL+L  N I D G   +   L  N++LL LSL  N I  +GA  +A  L A
Sbjct: 808 LESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCA 860



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 33/91 (36%), Positives = 53/91 (58%), Gaps = 4/91 (4%)

Query: 214  KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIA 273
            + + +++ +  L L+  +I   GAQ+LG+AL+     NRTL  L+L  N IG  GA  +A
Sbjct: 940  RALKVNTALTALYLQVASIGASGAQVLGEALAV----NRTLEILDLRGNAIGVAGAKALA 995

Query: 274  DGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
            + L++N SL  L+L  N +   GA+ +A  L
Sbjct: 996  NALKVNSSLRRLNLQENSLGMDGAICIATAL 1026



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 33/90 (36%), Positives = 47/90 (52%), Gaps = 4/90 (4%)

Query: 216  MALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADG 275
            +A++ T+  L LR N I   GA+ L  AL      N +L  LNL  N +G +GA  IA  
Sbjct: 970  LAVNRTLEILDLRGNAIGVAGAKALANALKV----NSSLRRLNLQENSLGMDGAICIATA 1025

Query: 276  LRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
            L  N  L  ++L  N I D GA  ++E ++
Sbjct: 1026 LSGNHRLQHINLQGNHIGDSGARMISEAIK 1055



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 7/87 (8%)

Query: 196  TLRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNR 252
            TL  + L GN +       L   + ++S++  L+L+ N++   GA  +  ALS     N 
Sbjct: 975  TLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSG----NH 1030

Query: 253  TLVSLNLGFNHIGDEGAGYIADGLRLN 279
             L  +NL  NHIGD GA  I++ ++ N
Sbjct: 1031 RLQHINLQGNHIGDSGARMISEAIKTN 1057


>gi|11545912 nucleotide-binding oligomerization domain containing 2
           [Homo sapiens]
          Length = 1040

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 52/146 (35%), Positives = 72/146 (49%), Gaps = 8/146 (5%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH---KLMAL 218
           LP L   +A+ L    ++D+ +   IE    C   L+K++L  N L +   H   KL+A 
Sbjct: 811 LPCLGVCKALYLRDNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLAC 869

Query: 219 DSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRL 278
                 L L NN I   GAQ+L + L      N +L  L    N +GDEGA  +A+ L  
Sbjct: 870 RQNFLALRLGNNYITAAGAQVLAEGLRG----NTSLQFLGFWGNRVGDEGAQALAEALGD 925

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
           ++SL WLSL  N I   GA  LA +L
Sbjct: 926 HQSLRWLSLVGNNIGSVGAQALALML 951



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 8/120 (6%)

Query: 188 ELLPLCSSTLRKVSLEGNPLPEQSYHKLMALD---STIAHLSLRNNNIDDRGAQLLGQAL 244
           +LLP C    + + L  N + ++   KL+        +  L+L NN + D  A  + + L
Sbjct: 809 QLLP-CLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLL 867

Query: 245 STLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
           +    C +  ++L LG N+I   GA  +A+GLR N SL +L    NR+ D+GA  LAE L
Sbjct: 868 A----CRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEAL 923


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 42/150 (28%), Positives = 73/150 (48%), Gaps = 6/150 (4%)

Query: 159  SKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPE---QSYHKL 215
            S+ L     L++++L    +TD+ +    + L +    L+K+ LE   +     QS    
Sbjct: 887  SQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASA 946

Query: 216  MALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADG 275
            +  + ++ HL L NN++ + G  LL +++   H    +L  L L   H+   G G++A  
Sbjct: 947  LVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHC---SLQRLMLNQCHLDTAGCGFLALA 1003

Query: 276  LRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
            L  N  L  LSL+ N ++D G   L EV+R
Sbjct: 1004 LMGNSWLTHLSLSMNPVEDNGVKLLCEVMR 1033



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 40/172 (23%), Positives = 70/172 (40%), Gaps = 34/172 (19%)

Query: 197 LRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLG--QALSTLHSCNRTL 254
           LR++ L  + L E++   L A    + H + +   +  R AQ+    Q L  +   NR L
Sbjct: 783 LRQLDLGSSILTERAMKTLCA---KLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNL 839

Query: 255 VSLNLGFNHIGDEGAGYIADGLRLNRSLLW-----------------------------L 285
            SLNLG  H+ +E      + L+  + LL                              L
Sbjct: 840 RSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSL 899

Query: 286 SLAHNRIQDKGALKLAEVLRAFELTHTEVVERRRLLLEKGTQERSRSPSSSR 337
           SLA N++ D+G + L++ LR  +    +++     +   G Q  + +  S+R
Sbjct: 900 SLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNR 951



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 26/90 (28%), Positives = 41/90 (45%), Gaps = 25/90 (27%)

Query: 219  DSTIAHLSLRNNNIDDRGAQLLGQ-------------------------ALSTLHSCNRT 253
            +S + HLSL  N ++D G +LL +                         +LS + S +R 
Sbjct: 1007 NSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRH 1066

Query: 254  LVSLNLGFNHIGDEGAGYIADGLRLNRSLL 283
            L SL+L  N +GD G   + +GL+   S+L
Sbjct: 1067 LKSLDLTDNALGDGGVAALCEGLKQKNSVL 1096


>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/80 (40%), Positives = 45/80 (56%), Gaps = 4/80 (5%)

Query: 225 LSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLW 284
           L L NN +   G   LG  L    S    L +LNLG N IG+EG  ++ +GL  NRS+L 
Sbjct: 323 LVLWNNQLTHTGMAFLGMTLPHTQS----LETLNLGHNPIGNEGVRHLKNGLISNRSVLR 378

Query: 285 LSLAHNRIQDKGALKLAEVL 304
           L LA  ++  +GA+ +AE +
Sbjct: 379 LGLASTKLTCEGAVAVAEFI 398



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/185 (28%), Positives = 77/185 (41%), Gaps = 22/185 (11%)

Query: 141 KEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSST---- 196
           K I  RGW+    ++   S CL      Q ++     L D +       L + SS     
Sbjct: 186 KHIGTRGWQAAAHMMRKTS-CL------QYLDARNTPLLDHSAPFVARALRIRSSLAVLH 238

Query: 197 LRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVS 256
           L   SL G PL        + ++  +  L L +N ++  G Q   Q L  L   N +L  
Sbjct: 239 LENASLSGRPL--MLLATALKMNMNLRELYLADNKLN--GLQDSAQ-LGNLLKFNCSLQI 293

Query: 257 LNLGFNHIGDEGAGYIADGLRLNR-SLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEVV 315
           L+L  NH+ D G  YI +GL+  R  L+ L L +N++   G   L        L HT+ +
Sbjct: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFL-----GMTLPHTQSL 348

Query: 316 ERRRL 320
           E   L
Sbjct: 349 ETLNL 353


>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/80 (40%), Positives = 45/80 (56%), Gaps = 4/80 (5%)

Query: 225 LSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLW 284
           L L NN +   G   LG  L    S    L +LNLG N IG+EG  ++ +GL  NRS+L 
Sbjct: 323 LVLWNNQLTHTGMAFLGMTLPHTQS----LETLNLGHNPIGNEGVRHLKNGLISNRSVLR 378

Query: 285 LSLAHNRIQDKGALKLAEVL 304
           L LA  ++  +GA+ +AE +
Sbjct: 379 LGLASTKLTCEGAVAVAEFI 398



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/185 (28%), Positives = 77/185 (41%), Gaps = 22/185 (11%)

Query: 141 KEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSST---- 196
           K I  RGW+    ++   S CL      Q ++     L D +       L + SS     
Sbjct: 186 KHIGTRGWQAAAHMMRKTS-CL------QYLDARNTPLLDHSAPFVARALRIRSSLAVLH 238

Query: 197 LRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVS 256
           L   SL G PL        + ++  +  L L +N ++  G Q   Q L  L   N +L  
Sbjct: 239 LENASLSGRPL--MLLATALKMNMNLRELYLADNKLN--GLQDSAQ-LGNLLKFNCSLQI 293

Query: 257 LNLGFNHIGDEGAGYIADGLRLNR-SLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEVV 315
           L+L  NH+ D G  YI +GL+  R  L+ L L +N++   G   L        L HT+ +
Sbjct: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFL-----GMTLPHTQSL 348

Query: 316 ERRRL 320
           E   L
Sbjct: 349 ETLNL 353


>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 32/80 (40%), Positives = 45/80 (56%), Gaps = 4/80 (5%)

Query: 225 LSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLW 284
           L L NN +   G   LG  L    S    L +LNLG N IG+EG  ++ +GL  NRS+L 
Sbjct: 323 LVLWNNQLTHTGMAFLGMTLPHTQS----LETLNLGHNPIGNEGVRHLKNGLISNRSVLR 378

Query: 285 LSLAHNRIQDKGALKLAEVL 304
           L LA  ++  +GA+ +AE +
Sbjct: 379 LGLASTKLTCEGAVAVAEFI 398



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/185 (28%), Positives = 77/185 (41%), Gaps = 22/185 (11%)

Query: 141 KEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSST---- 196
           K I  RGW+    ++   S CL      Q ++     L D +       L + SS     
Sbjct: 186 KHIGTRGWQAAAHMMRKTS-CL------QYLDARNTPLLDHSAPFVARALRIRSSLAVLH 238

Query: 197 LRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVS 256
           L   SL G PL        + ++  +  L L +N ++  G Q   Q L  L   N +L  
Sbjct: 239 LENASLSGRPL--MLLATALKMNMNLRELYLADNKLN--GLQDSAQ-LGNLLKFNCSLQI 293

Query: 257 LNLGFNHIGDEGAGYIADGLRLNR-SLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEVV 315
           L+L  NH+ D G  YI +GL+  R  L+ L L +N++   G   L        L HT+ +
Sbjct: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFL-----GMTLPHTQSL 348

Query: 316 ERRRL 320
           E   L
Sbjct: 349 ETLNL 353


>gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]
          Length = 501

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 5/95 (5%)

Query: 220 STIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLN 279
           S +  L+L NN +   GAQ L  AL+     N  L+SLNL  N I DEG   +A  L+ N
Sbjct: 334 SRLRVLNLANNQVRAPGAQSLAHALAH----NTNLISLNLRLNCIEDEGGQALAHALQTN 389

Query: 280 RSLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEV 314
           + L  L L  N + +  A  L++VL A   T T +
Sbjct: 390 KCLTTLHLGGNELSEPTATLLSQVL-AINTTLTSI 423



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 58/240 (24%), Positives = 103/240 (42%), Gaps = 30/240 (12%)

Query: 95  ASLSEKATLDDPRLSGSCSLNSLESKYVF-FRPTIQVELEQEDSKSVKEIYIRGWKVEER 153
           A LS    LD       C +N   + ++F +R  + +    +   ++K   +   KV++ 
Sbjct: 235 AGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDD 294

Query: 154 ILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPE---Q 210
              +  + L     L+ ++L +  + D+      +LL    S LR ++L  N +     Q
Sbjct: 295 KARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS--HSRLRVLNLANNQVRAPGAQ 352

Query: 211 SYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQAL------STLH---------------- 248
           S    +A ++ +  L+LR N I+D G Q L  AL      +TLH                
Sbjct: 353 SLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQ 412

Query: 249 --SCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
             + N TL S+NL  NHIG +G   + +G+  N++LL   L  + +  +    + + L A
Sbjct: 413 VLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYA 472



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 10/91 (10%)

Query: 193 CSSTLRKVSLEGNPLPEQS---YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
           C +TL    L GN L E +     +++A+++T+  ++L  N+I   G + L + +S    
Sbjct: 391 CLTTLH---LGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSD--- 444

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNR 280
            N+TL+  +L  + +  E    I   L  NR
Sbjct: 445 -NKTLLEFDLRLSDVAQESEYLIGQALYANR 474


>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
          Length = 488

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 36/115 (31%), Positives = 60/115 (52%), Gaps = 7/115 (6%)

Query: 197 LRKVSLEGNPLPE---QSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRT 253
           ++K+ L  N   +   +   +++A++  +  L L  NN   RGA  L   L      N T
Sbjct: 220 IKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRG----NVT 275

Query: 254 LVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 308
           L  L+L  N  G+E A  + + LRLNR L++L +  N I ++GA K+++ L + E
Sbjct: 276 LTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNE 330



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 35/104 (33%), Positives = 51/104 (49%), Gaps = 4/104 (3%)

Query: 221 TIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNR 280
           T+  L L  N   +  A  LG+ L      NR LV L++G N IG+EGA  I+ GL  N 
Sbjct: 275 TLTKLDLSMNGFGNEVALALGEVLRL----NRCLVYLDIGGNDIGNEGASKISKGLESNE 330

Query: 281 SLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEVVERRRLLLEK 324
           SL  L L  N I   GA+ L   ++    +  E ++   +L+ +
Sbjct: 331 SLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSE 374



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 11/99 (11%)

Query: 222 IAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRS 281
           +  L L +N I + G   L + L      N  L  +N+  NH+G EGA  I+D    N S
Sbjct: 135 VTKLELEDNCIMEEGVLSLVEMLQE----NYYLQEMNISNNHLGLEGARIISDFFERNSS 190

Query: 282 LLW-LSLAHNRIQDKGALKLAEVL------RAFELTHTE 313
            +W L L+ N  ++  A  L + L      +  +L+H +
Sbjct: 191 SIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
           sapiens]
          Length = 1043

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 3/92 (3%)

Query: 221 TIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNR 280
           ++ HL+L  N++ D G + L +AL         L SLNL       EG G +A+ L  N 
Sbjct: 896 SLTHLNLSKNSLRDEGVKFLCEALGRPDG---NLQSLNLSGCSFTREGCGELANALSHNH 952

Query: 281 SLLWLSLAHNRIQDKGALKLAEVLRAFELTHT 312
           ++  L L  N +QD G   L E L+     HT
Sbjct: 953 NVKILDLGENDLQDDGVKLLCEALKPHRALHT 984



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/126 (30%), Positives = 58/126 (46%), Gaps = 6/126 (4%)

Query: 182 TLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIAH---LSLRNNNIDDRGAQ 238
           T+   ++ L   +  L+ + LE   L   S   L    ++I H   L L  N + D G +
Sbjct: 797 TVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIK 856

Query: 239 LLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGAL 298
           LL  AL T   C   L  L L F  +      +++D L  NRSL  L+L+ N ++D+G  
Sbjct: 857 LLCAAL-THPKC--ALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVK 913

Query: 299 KLAEVL 304
            L E L
Sbjct: 914 FLCEAL 919



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 9/129 (6%)

Query: 164 PLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMAL----D 219
           P   L+ + LW   L         + L L + +L  ++L  N L ++    L       D
Sbjct: 865 PKCALERLELWFCQLAAPACKHLSDAL-LQNRSLTHLNLSKNSLRDEGVKFLCEALGRPD 923

Query: 220 STIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLN 279
             +  L+L   +    G   L  ALS  H+       L+LG N + D+G   + + L+ +
Sbjct: 924 GNLQSLNLSGCSFTREGCGELANALSHNHNVK----ILDLGENDLQDDGVKLLCEALKPH 979

Query: 280 RSLLWLSLA 288
           R+L  L LA
Sbjct: 980 RALHTLGLA 988


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 43/138 (31%), Positives = 61/138 (44%), Gaps = 6/138 (4%)

Query: 171 INLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL-MALDST--IAHLSL 227
           +NL    L D  +    E L      L ++SLE   L E     L +AL S   + HL L
Sbjct: 791 LNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCL 850

Query: 228 RNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSL 287
            +N + D G +L+  AL       ++LV     F  +  E   Y++  L  N+SL  L L
Sbjct: 851 ADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSE---YLSTSLLHNKSLTHLDL 907

Query: 288 AHNRIQDKGALKLAEVLR 305
             N +QD G   L +V R
Sbjct: 908 GSNWLQDNGVKLLCDVFR 925



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 45/207 (21%), Positives = 77/207 (37%), Gaps = 56/207 (27%)

Query: 168 LQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPE--QSYHKLMALDSTIAHL 225
           L+ ++L+   L    +      L   +  L+K+ L+    P+  Q     +  +  + HL
Sbjct: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734

Query: 226 SLRNNNIDDRGAQLLGQALS---------TLHSCNRT----------------LVSLNLG 260
            L+ ++I D G + L +AL           L SCN T                L+ LNL 
Sbjct: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794

Query: 261 FNHIGDEGAGYIADGLR-----------------------------LNRSLLWLSLAHNR 291
            N++ D+G   + + LR                              N+ L  L LA N 
Sbjct: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854

Query: 292 IQDKGALKLAEVLRAFELTHTEVVERR 318
           + D G   +++ L+  + T   +V RR
Sbjct: 855 LGDGGVKLMSDALQHAQCTLKSLVLRR 881



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 13/147 (8%)

Query: 164  PLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIA 223
            P   LQ + L    LT+        ++ L +  LR + L  N L +     L        
Sbjct: 927  PSCNLQDLELMGCVLTNACCLDLASVI-LNNPNLRSLDLGNNDLQDDGVKILCDA----- 980

Query: 224  HLSLRNNNIDDRGAQLLG------QALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLR 277
             L   N NI   G +  G      Q LS+   CN+ L+ +NL  N +G EG   +   L+
Sbjct: 981  -LRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLK 1039

Query: 278  LNRSLLWLSLAHNRIQDKGALKLAEVL 304
              +  L +        D+ A KL E +
Sbjct: 1040 SPKCKLQVLGLCKEAFDEEAQKLLEAV 1066


>gi|5174617 nucleotide-binding oligomerization domain containing 1
           [Homo sapiens]
          Length = 953

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 29/84 (34%), Positives = 43/84 (51%), Gaps = 4/84 (4%)

Query: 222 IAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRS 281
           + HL L  N I   G + L  A+      ++++  + +  N +GDEGA   A+ LR + S
Sbjct: 786 LTHLKLGKNKITSEGGKYLALAVKN----SKSISEVGMWGNQVGDEGAKAFAEALRNHPS 841

Query: 282 LLWLSLAHNRIQDKGALKLAEVLR 305
           L  LSLA N I  +G   LA  L+
Sbjct: 842 LTTLSLASNGISTEGGKSLARALQ 865



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 34/116 (29%), Positives = 63/116 (54%), Gaps = 7/116 (6%)

Query: 194 SSTLRKVSLEGNPLPEQ---SYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSC 250
           S ++ +V + GN + ++   ++ + +    ++  LSL +N I   G + L +AL      
Sbjct: 811 SKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQ---- 866

Query: 251 NRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
           N +L  L L  N + DE A  +A+ L++N++L  L L  N+I  KG  +LA+ L++
Sbjct: 867 NTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQS 922



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 38/122 (31%), Positives = 62/122 (50%), Gaps = 10/122 (8%)

Query: 188 ELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDST----IAHLSLRNNNIDDRGAQLLGQA 243
           EL P C S L  + L  N + +    K+++ + T    + +L L NN I D GA+ + + 
Sbjct: 722 ELQP-CFSRLTVLRLSVNQITDGGV-KVLSEELTKYKIVTYLGLYNNQITDVGARYVTKI 779

Query: 244 LSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEV 303
           L       + L  L LG N I  EG  Y+A  ++ ++S+  + +  N++ D+GA   AE 
Sbjct: 780 LDEC----KGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEA 835

Query: 304 LR 305
           LR
Sbjct: 836 LR 837



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 34/133 (25%), Positives = 60/133 (45%), Gaps = 8/133 (6%)

Query: 168 LQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQ---SYHKLMALDSTIAH 224
           +  + +W   + D+    F E L    S L  +SL  N +  +   S  + +  ++++  
Sbjct: 814 ISEVGMWGNQVGDEGAKAFAEALRNHPS-LTTLSLASNGISTEGGKSLARALQQNTSLEI 872

Query: 225 LSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLW 284
           L L  N ++D  A+ L + L      N+TL  L L  N I  +G   +AD L+ N  +  
Sbjct: 873 LWLTQNELNDEVAESLAEMLKV----NQTLKHLWLIQNQITAKGTAQLADALQSNTGITE 928

Query: 285 LSLAHNRIQDKGA 297
           + L  N I+ + A
Sbjct: 929 ICLNGNLIKPEEA 941


>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
          Length = 975

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 7/150 (4%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLM---AL 218
           LP   + + + L    L  +      +LL      +  + L  NPL       LM   A 
Sbjct: 746 LPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAG 805

Query: 219 DSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRL 278
           ++++ HLSL +  + D G +LL   L      NR L  LN+ +N  GD  A  +A   R 
Sbjct: 806 NTSVTHLSLLHTGLGDEGLELLAAQLDR----NRQLQELNVAYNGAGDTAALALARAARE 861

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVLRAFE 308
           + SL  L L  N +  +G   L ++  A E
Sbjct: 862 HPSLELLHLYFNELSSEGRQVLRDLGGAAE 891



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 48/151 (31%), Positives = 67/151 (44%), Gaps = 15/151 (9%)

Query: 168 LQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMAL----DSTIA 223
           L  +NL    L    L T   LLP+     RK+ L+ N L  ++   L  L       I 
Sbjct: 727 LDEVNLASCQLDPAGLRT---LLPVFLRA-RKLGLQLNSLGPEACKDLRDLLLHDQCQIT 782

Query: 224 HLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLL 283
            L L NN +   G  +L + L+     N ++  L+L    +GDEG   +A  L  NR L 
Sbjct: 783 TLRLSNNPLTAAGVAVLMEGLAG----NTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQ 838

Query: 284 WLSLAHNRIQDKGALKLAEVLR---AFELTH 311
            L++A+N   D  AL LA   R   + EL H
Sbjct: 839 ELNVAYNGAGDTAALALARAAREHPSLELLH 869


>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
          Length = 670

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 43/143 (30%), Positives = 70/143 (48%), Gaps = 16/143 (11%)

Query: 171 INLWKVGLTDKTLTTFIELLP---LCSSTLRK---VSLEGNPLPEQSYHKLMALDSTIAH 224
           ++L    LT +T     +LLP   LC+  +     +S EG  L  +     +  ++ +  
Sbjct: 35  LDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRG----LCANTVLRF 90

Query: 225 LSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIG--DEGAGYIADGLRLNRSL 282
           L L+ NN+   GA+ LG+ L      N+++ SL L +N +G  D+       GL  N +L
Sbjct: 91  LDLKGNNLRAAGAEALGKLLQQ----NKSIQSLTLEWNSLGTWDDAFATFCGGLAANGAL 146

Query: 283 LWLSLAHNRIQDKGALKLAEVLR 305
             L L +N+I  KGA +LA  L+
Sbjct: 147 QRLDLRNNQISHKGAEELALALK 169


>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
          Length = 419

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 35/113 (30%), Positives = 60/113 (53%), Gaps = 6/113 (5%)

Query: 194 SSTLRKVSLEGNPLPEQSYH--KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCN 251
           +S+L K+ L    L E + H  +++  +  +  L +  ++I + G Q L  AL      N
Sbjct: 193 NSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYL----N 248

Query: 252 RTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
            +L  L++  N I  +G  Y+AD L+ N +L  + L+ NRI++ GA  L+E L
Sbjct: 249 SSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETL 301



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 23/52 (44%), Positives = 33/52 (63%)

Query: 254 LVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
           L+ LNL FN IG EG   IA  L  NR+L +L +  N+I++KG +  A +L+
Sbjct: 140 LIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 46/213 (21%), Positives = 103/213 (48%), Gaps = 19/213 (8%)

Query: 97  LSEKATLDDPRLSGSCSLNSLESKY-VFFRPTIQVELEQEDSKSVKEIYIRGWKVEERIL 155
           L +  TL   R++G    N +E+K  +FF   +Q+      + S++++ +    +EE  +
Sbjct: 162 LHKNRTLKYLRMTG----NKIENKGGMFFAAMLQI------NSSLEKLDLGDCDLEESTV 211

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
            V  + L     L A+++ K  + +  +    + L L +S+LR + +  N +       L
Sbjct: 212 HV-GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYL-NSSLRYLDVSCNKITHDGMVYL 269

Query: 216 ---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYI 272
              +  ++T+  + L  N I++ GA  L +   TL S NR+L +L++  N+I  EG   +
Sbjct: 270 ADVLKSNTTLEVIDLSFNRIENAGANYLSE---TLTSHNRSLKALSVVSNNIEGEGLVAL 326

Query: 273 ADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
           +  ++ N +   + +  N+  +   +  +++++
Sbjct: 327 SQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQ 359



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 4/74 (5%)

Query: 214 KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIA 273
           KL+     + +L+L  N+I   G +L+ + L      NRTL  L +  N I ++G  + A
Sbjct: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHK----NRTLKYLRMTGNKIENKGGMFFA 187

Query: 274 DGLRLNRSLLWLSL 287
             L++N SL  L L
Sbjct: 188 AMLQINSSLEKLDL 201


>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
            sapiens]
          Length = 1866

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 51/170 (30%), Positives = 75/170 (44%), Gaps = 35/170 (20%)

Query: 167  QLQAINLWKVGLT--DKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMALDSTIAH 224
            +LQ ++L +V L   D   +  ++ L L  S L+   L  + +  +    L  L S + H
Sbjct: 1464 RLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEG---LAHLASGLGH 1520

Query: 225  ------LSLRNNNIDDRGAQLLGQAL------------------STL----HSCNRT--L 254
                  L L NN  D+ G + L +AL                  STL    H  ++   L
Sbjct: 1521 CHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCL 1580

Query: 255  VSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL L  N IGD G  ++++ LR   SL  L L+HN+I D G   LA +L
Sbjct: 1581 QSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATIL 1630



 Score = 38.1 bits (87), Expect = 0.021
 Identities = 31/92 (33%), Positives = 44/92 (47%), Gaps = 5/92 (5%)

Query: 213  HKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYI 272
            H+L  + + +  L L  N+I D G   L +AL    S    L  L+L  N IGD G  ++
Sbjct: 1572 HRLSQM-TCLQSLRLNRNSIGDVGCCHLSEALRAATS----LEELDLSHNQIGDAGVQHL 1626

Query: 273  ADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
            A  L     L  + L+ N I   G ++LAE L
Sbjct: 1627 ATILPGLPELRKIDLSGNSISSAGGVQLAESL 1658



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 28/166 (16%)

Query: 150  VEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPE 209
            + ++ L     CLP L QL  + L + GL+ K+       L LC   ++KV L       
Sbjct: 1147 LSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLC-PRVKKVDL------- 1198

Query: 210  QSYHKLMALDSTIAHLSLRNNNIDDRG---AQLLGQALSTLH--------SCNRTLVSLN 258
            +S H         A L  R+N  ++ G    +  G +LS  H        S  + L  ++
Sbjct: 1199 RSLHH--------ATLHFRSNE-EEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVD 1249

Query: 259  LGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
            L  N +GD G   + + L        L L+HN I  + AL L E L
Sbjct: 1250 LSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETL 1295



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 14/170 (8%)

Query: 159  SKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL--- 215
            S+ L   T L+ ++L    + D  +     +LP     LRK+ L GN +      +L   
Sbjct: 1599 SEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAES 1657

Query: 216  MALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADG 275
            + L   +  L L  N + D  A  L Q L       + L  L+L F+H+G  GA  +A  
Sbjct: 1658 LVLCRRLEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQA 1711

Query: 276  LRLNRSLLWLSLAHNRIQDKGALKLA---EVLRAFELTHTEVVERRRLLL 322
            L  +  L  +SLA N +   G L+      +LR  +L   ++  +   LL
Sbjct: 1712 LDGSPHLEEISLAENNLAG-GVLRFCMELPLLRQIDLVSCKIDNQTAKLL 1760



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 34/111 (30%), Positives = 51/111 (45%), Gaps = 5/111 (4%)

Query: 194  SSTLRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRT 253
            S  L ++SL  N L        M L   +  + L +  ID++ A+LL  + ++  +    
Sbjct: 1715 SPHLEEISLAENNLAGGVLRFCMELP-LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVI 1773

Query: 254  LVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 304
            L+S NL    +GDE A  +A  L     L  + L  N+I   GA  LAE L
Sbjct: 1774 LLSWNL----LGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGL 1820


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/205 (23%), Positives = 83/205 (40%), Gaps = 46/205 (22%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQS---------- 211
           L P ++L+ + +W+ G+T K       +L     +L+++SL GN L ++           
Sbjct: 252 LHPSSRLRTLWIWECGITAKGCGDLCRVLR-AKESLKELSLAGNELGDEGARLLCETLLE 310

Query: 212 ----------------------YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHS 249
                                 +  ++A +  +  L + NN ++D G + L Q L    S
Sbjct: 311 PGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGS 370

Query: 250 CNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR---- 305
             R L    L    + D     +A  L  N SL  L L++N + D G L+L E +R    
Sbjct: 371 VLRVLW---LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 306 ------AFELTHTEVVERRRLLLEK 324
                  +++  +E +E R   LEK
Sbjct: 428 LLEQLVLYDIYWSEEMEDRLQALEK 452



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 24/161 (14%)

Query: 158 FSKCLPPLTQLQAINLWKVGLTD---KTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYH- 213
           +++ LP L Q Q + L   GLT+   K +++ + + P     L +++L  N L +   H 
Sbjct: 20  WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNP----ALAELNLRSNELGDVGVHC 75

Query: 214 ---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
               L      I  LSL+N  +   G  +L   L TL     TL  L+L  N +GD G  
Sbjct: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLP----TLQELHLSDNLLGDAGLQ 131

Query: 271 YIADGL-----RLNRSLLWLSLAHNRIQDKGALKLAEVLRA 306
            + +GL     RL +    L L +  +       LA VLRA
Sbjct: 132 LLCEGLLDPQCRLEK----LQLEYCSLSAASCEPLASVLRA 168



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 56/206 (27%), Positives = 72/206 (34%), Gaps = 57/206 (27%)

Query: 156 GVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKL 215
           GV S  L  L  LQ ++L    L D  L    E L      L K+ LE   L   S   L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162

Query: 216 MAL---DSTIAHLSLRNNNIDDRGAQLLGQALST---------LHSCNRT---------- 253
            ++         L++ NN+I++ G ++L Q L           L SC  T          
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222

Query: 254 ------LVSLNLGFNHIGDEGAGYIADGL-----------------------------RL 278
                 L  L LG N +GD G   +  GL                             R 
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282

Query: 279 NRSLLWLSLAHNRIQDKGALKLAEVL 304
             SL  LSLA N + D+GA  L E L
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETL 308


>gi|156938336 class II transactivator [Homo sapiens]
          Length = 1130

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 38/95 (40%), Positives = 49/95 (51%), Gaps = 8/95 (8%)

Query: 214  KLMALDSTIAHL---SLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAG 270
            +++   S++ HL   +L  N I D G   L      L S    L +LNL  N+I D GA 
Sbjct: 978  RILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKS----LETLNLSQNNITDLGAY 1033

Query: 271  YIADGL-RLNRSLLWLSLAHNRIQDKGALKLAEVL 304
             +A+ L  L  SLL LSL +N I D GA  LA VL
Sbjct: 1034 KLAEALPSLAASLLRLSLYNNCICDVGAESLARVL 1068



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 23/99 (23%), Positives = 47/99 (47%), Gaps = 3/99 (3%)

Query: 149  KVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLP 208
            K+ +  +   S   P L  L+ +NL +  +TD       E LP  +++L ++SL  N + 
Sbjct: 998  KIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCIC 1057

Query: 209  E---QSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQAL 244
            +   +S  +++    ++  + ++ N     GAQ L  +L
Sbjct: 1058 DVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASL 1096



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 37/129 (28%), Positives = 60/129 (46%), Gaps = 13/129 (10%)

Query: 153  RILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSY 212
            RIL  FS        L A++  K+G  D+ ++      P   S L  ++L  N + +   
Sbjct: 978  RILTAFSSLQH--LDLDALSENKIG--DEGVSQLSATFPQLKS-LETLNLSQNNITDLGA 1032

Query: 213  HKLM----ALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEG 268
            +KL     +L +++  LSL NN I D GA+ L + L  + S    L  +++ +N     G
Sbjct: 1033 YKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVS----LRVMDVQYNKFTAAG 1088

Query: 269  AGYIADGLR 277
            A  +A  LR
Sbjct: 1089 AQQLAASLR 1097


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 32/109 (29%), Positives = 58/109 (53%), Gaps = 4/109 (3%)

Query: 197 LRKVSLEGNPLPEQSYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVS 256
           L  V+   +P+  +    L+  +  + +L++  N +D  G  LL +AL    S +  LV 
Sbjct: 728 LALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDT-GVPLLCEALC---SPDTVLVY 783

Query: 257 LNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 305
           L L F H+ ++   YI++ L  N+S+ +L L+ N ++D+G   L E L+
Sbjct: 784 LMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALK 832


>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
          Length = 921

 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 45/142 (31%), Positives = 63/142 (44%), Gaps = 12/142 (8%)

Query: 168 LQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLMAL----DSTIA 223
           L  +NL    L    L T   LLP+     RK+ L+ N L  ++   L  L       I 
Sbjct: 727 LDEVNLASCQLDPAGLRT---LLPVFLRA-RKLGLQLNSLGPEACKDLRDLLLHDQCQIT 782

Query: 224 HLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLL 283
            L L NN +   G  +L + L+     N ++  L+L    +GDEG   +A  L  NR L 
Sbjct: 783 TLRLSNNPLTAAGVAVLMEGLAG----NTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQ 838

Query: 284 WLSLAHNRIQDKGALKLAEVLR 305
            L++A+N   D  AL LA   R
Sbjct: 839 ELNVAYNGAGDTAALALARAAR 860



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 7/124 (5%)

Query: 162 LPPLTQLQAINLWKVGLTDKTLTTFIELLPLCSSTLRKVSLEGNPLPEQSYHKLM---AL 218
           LP   + + + L    L  +      +LL      +  + L  NPL       LM   A 
Sbjct: 746 LPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAG 805

Query: 219 DSTIAHLSLRNNNIDDRGAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRL 278
           ++++ HLSL +  + D G +LL   L      NR L  LN+ +N  GD  A  +A   R 
Sbjct: 806 NTSVTHLSLLHTGLGDEGLELLAAQLDR----NRQLQELNVAYNGAGDTAALALARAARE 861

Query: 279 NRSL 282
           + SL
Sbjct: 862 HPSL 865


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/137 (30%), Positives = 65/137 (47%), Gaps = 16/137 (11%)

Query: 323 EKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALV-DKTDKTQTMKTPKGLGKKKEKS 381
           EKG+Q    + S S     K ++E S+  GIS       K  K+ T+   K  G KKE +
Sbjct: 44  EKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPT 103

Query: 382 W-----ELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQKPSRAKGIKIGSREKR 436
                 ++  KEE L   Q   +G   +E A K  + KV + E+KPS      +   EK 
Sbjct: 104 QAVVEEQVLDKEEPLPEEQRQAKG-DAEEMAQKKQEIKVEVKEEKPS------VSKEEKP 156

Query: 437 SILLESELVVEATEVVN 453
           S+   S++ ++ TE+V+
Sbjct: 157 SV---SKVEMQPTELVS 170


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/137 (30%), Positives = 65/137 (47%), Gaps = 16/137 (11%)

Query: 323 EKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALV-DKTDKTQTMKTPKGLGKKKEKS 381
           EKG+Q    + S S     K ++E S+  GIS       K  K+ T+   K  G KKE +
Sbjct: 44  EKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPT 103

Query: 382 W-----ELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQKPSRAKGIKIGSREKR 436
                 ++  KEE L   Q   +G   +E A K  + KV + E+KPS      +   EK 
Sbjct: 104 QAVVEEQVLDKEEPLPEEQRQAKG-DAEEMAQKKQEIKVEVKEEKPS------VSKEEKP 156

Query: 437 SILLESELVVEATEVVN 453
           S+   S++ ++ TE+V+
Sbjct: 157 SV---SKVEMQPTELVS 170


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 42/137 (30%), Positives = 65/137 (47%), Gaps = 16/137 (11%)

Query: 323 EKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALV-DKTDKTQTMKTPKGLGKKKEKS 381
           EKG+Q    + S S     K ++E S+  GIS       K  K+ T+   K  G KKE +
Sbjct: 44  EKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPT 103

Query: 382 W-----ELAKKEEKLGSGQSPTQGTPKKEDATKAGKGKVTIPEQKPSRAKGIKIGSREKR 436
                 ++  KEE L   Q   +G   +E A K  + KV + E+KPS      +   EK 
Sbjct: 104 QAVVEEQVLDKEEPLPEEQRQAKG-DAEEMAQKKQEIKVEVKEEKPS------VSKEEKP 156

Query: 437 SILLESELVVEATEVVN 453
           S+   S++ ++ TE+V+
Sbjct: 157 SV---SKVEMQPTELVS 170


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,622,327
Number of Sequences: 37866
Number of extensions: 1097210
Number of successful extensions: 4841
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 4333
Number of HSP's gapped (non-prelim): 565
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.