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Search of human proteins with 162287076
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 1255 0.0
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 1108 0.0
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 461 e-130
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 430 e-120
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 430 e-120
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 231 1e-60
gi|148529025 pleckstrin homology domain containing, family G (wi... 197 2e-50
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 192 8e-49
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 192 8e-49
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 184 3e-46
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 184 3e-46
gi|193211603 pleckstrin homology domain containing, family G (wi... 175 1e-43
gi|193211598 pleckstrin homology domain containing, family G (wi... 175 1e-43
gi|193211596 pleckstrin homology domain containing, family G (wi... 175 1e-43
gi|193211594 pleckstrin homology domain containing, family G (wi... 175 1e-43
gi|55742734 pleckstrin homology domain containing, family G (wit... 175 1e-43
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 156 5e-38
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 126 5e-29
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 126 5e-29
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 114 3e-25
gi|71274148 pleckstrin homology domain containing, family G (wit... 113 6e-25
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 104 2e-22
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 85 2e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens] 85 2e-16
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 77 4e-14
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 77 5e-14
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 76 1e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 75 2e-13
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 74 4e-13
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 72 2e-12
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
Length = 619
Score = 1255 bits (3247), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDR 60
MKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDR
Sbjct: 1 MKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDR 60
Query: 61 EHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRW 120
EHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRW
Sbjct: 61 EHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRW 120
Query: 121 LDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEE 180
LDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEE
Sbjct: 121 LDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEE 180
Query: 181 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG 240
TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG
Sbjct: 181 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG 240
Query: 241 RDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEH 300
RDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEH
Sbjct: 241 RDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEH 300
Query: 301 VVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQ 360
VVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQ
Sbjct: 301 VVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQ 360
Query: 361 AVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV 420
AVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV
Sbjct: 361 AVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV 420
Query: 421 FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGI 480
FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGI
Sbjct: 421 FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGI 480
Query: 481 QRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGS 540
QRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGS
Sbjct: 481 QRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGS 540
Query: 541 PGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSP 600
PGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSP
Sbjct: 541 PGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSP 600
Query: 601 TPKTPPCQARLAKLDEDEL 619
TPKTPPCQARLAKLDEDEL
Sbjct: 601 TPKTPPCQARLAKLDEDEL 619
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
sapiens]
Length = 580
Score = 1108 bits (2866), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 72 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 131
ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE
Sbjct: 33 ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 92
Query: 132 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 191
TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE
Sbjct: 93 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 152
Query: 192 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 251
QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ
Sbjct: 153 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 212
Query: 252 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 311
IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE
Sbjct: 213 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 272
Query: 312 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 371
ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR
Sbjct: 273 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 332
Query: 372 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 431
CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE
Sbjct: 333 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 392
Query: 432 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 491
ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA
Sbjct: 393 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 452
Query: 492 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 551
ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ
Sbjct: 453 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 512
Query: 552 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 611
GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL
Sbjct: 513 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 572
Query: 612 AKLDEDEL 619
AKLDEDEL
Sbjct: 573 AKLDEDEL 580
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 461 bits (1186), Expect = e-130
Identities = 273/581 (46%), Positives = 364/581 (62%), Gaps = 34/581 (5%)
Query: 51 RTEGDHRRDREHEVLAGALQPESYSIAG-----SEGSISASAASGLAAPSGPSSGLSSGP 105
R D ++ + A Q E+ G S G++S S++SG+ + G G
Sbjct: 1807 RKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQS-CGEEEGEEGAD 1865
Query: 106 CSPGPPGPVSGLRRWLDH-------SKHCLSVETEADSGQAGPYENWMLEPALATGEELP 158
P PP L S L T +++ A + +E + + L
Sbjct: 1866 AVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVS-AIEELVKSKMALE 1924
Query: 159 ELTLLTTLLEGPGDKTQP---PEEETL--SQAPESE-EEQKKKALERSMYVLSELVETEK 212
+ ++LL GD + P P + +L S +P E EE+K +L+R YVL ELVETE+
Sbjct: 1925 DRP--SSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETER 1982
Query: 213 MYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPD 272
YV DLG +VEGYMA M GVP+ ++G+D+IVFGNI QIY+WHRD+FL EL++CL+DP+
Sbjct: 1983 DYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE 2042
Query: 273 WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQ 332
L LF+KHERRLHMY+ YCQNKPKSEH+VSE+ D++FE+L+Q+LGHRLQL DLLIKPVQ
Sbjct: 2043 KLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQ 2102
Query: 333 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQG 392
RIMKYQLLLKDFLKY +A +DT++LE+AVEVMC VP+RCNDMM +GRL+GF+GK+ AQG
Sbjct: 2103 RIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQG 2162
Query: 393 KLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIK 452
KLL QDTF VT+ +AG L R RERR+FLFEQI+IFSE L +G + PG+++KNSIK
Sbjct: 2163 KLLLQDTFLVTDQDAG--LLPRCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIK 2219
Query: 453 VSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLN 512
VSCL LE N++ DPC+FALTSR + ++ ++L ++ P++ Q WI + QILE+QR+FLN
Sbjct: 2220 VSCLCLEENVENDPCKFALTSRTGD-VVETFILHSSSPSVRQTWIHEINQILENQRNFLN 2278
Query: 513 ALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHT--PIN-GSLPSLLLSP 569
AL SPIEYQR S G G G G G G + GS H+ P + G PS S
Sbjct: 2279 ALTSPIEYQRNHSGGGGGGGSGGSG-GGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSR 2337
Query: 570 KGEVARALL----PLDKQALGDIPQAPHDSPPVSPTPKTPP 606
+ + + L A +A S +P P PP
Sbjct: 2338 PSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPP 2378
Score = 236 bits (601), Expect = 6e-62
Identities = 131/370 (35%), Positives = 212/370 (57%), Gaps = 12/370 (3%)
Query: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQG 233
P E L A E+K+K+ R ++++EL++TEK YV DL + ++ Y+ T +
Sbjct: 1269 PGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE 1328
Query: 234 VPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQ 293
+P + ++ I+FGN+Q+IYE+H + FL+EL++ + P+ + F+ + MYV YC+
Sbjct: 1329 IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCK 1388
Query: 294 NKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM 353
NKP S ++ E SYF+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 1389 NKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG-- 1446
Query: 354 DTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSS 413
+++ +EVM VPKR ND M L L GF+ + +QG+L+ Q++F V +P+ L
Sbjct: 1447 -KGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT---LIR 1502
Query: 414 RGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS 473
+GRER +FLFE ++FS+ + + Y+YK+ + S LG+ +++GDPC+FAL
Sbjct: 1503 KGRERHLFLFEMSLVFSKEVKD---SSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV 1559
Query: 474 RGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEYQRRESQTNSLGR 532
+ VL+A+ Q WIKH+ ++++ + L AL+ PI + T GR
Sbjct: 1560 GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR 1619
Query: 533 PRGPGVGSPG 542
G + S G
Sbjct: 1620 RDGEDLDSQG 1629
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 430 bits (1106), Expect = e-120
Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)
Query: 189 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 248
EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN
Sbjct: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 1978
Query: 249 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 308
I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037
Query: 309 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 368
YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V
Sbjct: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097
Query: 369 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 428
PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I
Sbjct: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 2155
Query: 429 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 488
FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA
Sbjct: 2156 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 2209
Query: 489 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 527
+ I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T
Sbjct: 2210 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 2248
Score = 231 bits (589), Expect = 1e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 179 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 236
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 237 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 296
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 297 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 356
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
Query: 357 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 416
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
Query: 417 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 476
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
Query: 477 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 529
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
Query: 530 LG--RPRGPGVGSPGRIRLGDQAQGST 554
+ +G G P I + + +T
Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 430 bits (1106), Expect = e-120
Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)
Query: 189 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 248
EEEQK KAL M+VL+ELV+TEK YV DLG +VEG+M + +GVPE +RG+D+IVFGN
Sbjct: 222 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 281
Query: 249 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 308
I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340
Query: 309 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 368
YFEE++Q++ RL L+D LIKP+QRI KYQLLLKDFL+Y +AG++ +D+E+AVE+MC V
Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400
Query: 369 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 428
PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG + SR +ERRVFLFEQI+I
Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 458
Query: 429 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 488
FSE L +G PGY++K SIK++ L LE N+ DPC+FAL +R +R VLQAA
Sbjct: 459 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 512
Query: 489 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 527
+ I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E T
Sbjct: 513 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 551
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 231 bits (589), Expect = 1e-60
Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)
Query: 179 EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 236
E L A E+K+K+ + ++++EL++TEK YV DL + +E Y+ T + +P
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320
Query: 237 SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 296
+ ++ I+FGNIQ+IY++H + FL+EL++ + P+ + F+ + MYV YC+NKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380
Query: 297 KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 356
S ++ E ++F+E++Q+ G ++ LIKPVQRI KYQLLLK+ L
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437
Query: 357 DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 416
+L+ +EVM VPK+ ND M + L GF+ L QG+L+ QD F V +P++ L +GR
Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494
Query: 417 ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 476
ER +FLFE ++FS+ + G T+ YVYKN + S LG+ +++GDPC+FAL S
Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551
Query: 477 EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 529
+ VL+A++ Q WIK++ ++++ + L AL+ P++ QR S+ +
Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611
Query: 530 LG--RPRGPGVGSPGRIRLGDQAQGST 554
+ +G G P I + + +T
Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 197 bits (501), Expect = 2e-50
Identities = 115/375 (30%), Positives = 204/375 (54%), Gaps = 21/375 (5%)
Query: 186 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIV 245
P E+ +++ R ++++E++ TE+ Y+ LG +++ Y M +P+ LRG+ ++
Sbjct: 792 PAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVI 851
Query: 246 FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEF 305
FGN+++++++H+ +FL+EL+RC P + + F++HE + MYV+Y +NKP+S+ ++S
Sbjct: 852 FGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSH 911
Query: 306 GDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYN---RAGMDTADLEQAV 362
G+++F++ +++LG ++ L L++PVQR+ KY LLL+D LK + G + +L A
Sbjct: 912 GNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAE 971
Query: 363 EVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 422
V+CF + ND++ + +RG + L QG+L +D F V + R VFL
Sbjct: 972 VVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-------CCGRKKYLRHVFL 1024
Query: 423 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQR 482
FE +I+FS+ G+ Y+YK S K + +G+ N+ RF + R
Sbjct: 1025 FEDLILFSKT---QKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDT 1081
Query: 483 YVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPG 542
Y+LQA+ + AW + +IL Q AL+S + R + S+G P +
Sbjct: 1082 YILQASSAEVKSAWTDVIGRILWRQ-----ALKS---RELRIQEMASMGIGNQPFMDVKP 1133
Query: 543 RIRLGDQAQGSTHTP 557
R R D A S P
Sbjct: 1134 RDRTPDCAVISDRAP 1148
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 192 bits (488), Expect = 8e-49
Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)
Query: 166 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY
Sbjct: 626 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 684
Query: 226 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 281
A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++
Sbjct: 685 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 744
Query: 282 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
+Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL
Sbjct: 745 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 804
Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 400
LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F
Sbjct: 805 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 863
Query: 401 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 453
V G L + +R +FL E+ ++F + G + P Y YK S+ +
Sbjct: 864 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 923
Query: 454 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
+ +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A
Sbjct: 924 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 977
Query: 514 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 543
+ +++ E Q+ SL P P SP R
Sbjct: 978 CREASQHRALE-QSQSLPLP-APTSTSPSR 1005
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 192 bits (488), Expect = 8e-49
Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)
Query: 166 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
L GP + + E+ + EE++ A+ R +V+SEL++TE+ YV++L ++EGY
Sbjct: 573 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 631
Query: 226 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 281
A M A + L + ++FGN+++IY +H FL+EL+ P+ + + F++
Sbjct: 632 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 691
Query: 282 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
+Y YCQNKP+SE + + D +F+E +++L H+L L+ L+KPVQRI KYQLL
Sbjct: 692 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 751
Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 400
LK+ LK Y+R DL++A+ + + K ND M L + G++G L GKLL Q +F
Sbjct: 752 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 810
Query: 401 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 453
V G L + +R +FL E+ ++F + G + P Y YK S+ +
Sbjct: 811 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 870
Query: 454 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
+ +G+ N++GD +F + E + Y++QA P I AW+ + ++L SQ L A
Sbjct: 871 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 924
Query: 514 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 543
+ +++ E Q+ SL P P SP R
Sbjct: 925 CREASQHRALE-QSQSLPLP-APTSTSPSR 952
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 184 bits (466), Expect = 3e-46
Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)
Query: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 234
P +E S P S + +VL+EL++TE++YV +L ++ GY A M +
Sbjct: 532 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 591
Query: 235 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 291
P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y
Sbjct: 592 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 651
Query: 292 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 652 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 710
Query: 351 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 408
+A L++A++ M + K ND M + G+ G L GK++ Q F W+ +
Sbjct: 711 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 770
Query: 409 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 463
+ R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++
Sbjct: 771 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 830
Query: 464 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 511
GD +F + E + Y++QA++ + W+K + IL Q++ L
Sbjct: 831 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 875
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 184 bits (466), Expect = 3e-46
Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)
Query: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 234
P +E S P S + +VL+EL++TE++YV +L ++ GY A M +
Sbjct: 472 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 531
Query: 235 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 291
P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y
Sbjct: 532 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 591
Query: 292 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 592 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 650
Query: 351 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 408
+A L++A++ M + K ND M + G+ G L GK++ Q F W+ +
Sbjct: 651 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 710
Query: 409 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 463
+ R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++
Sbjct: 711 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 770
Query: 464 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 511
GD +F + E + Y++QA++ + W+K + IL Q++ L
Sbjct: 771 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 815
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 175 bits (444), Expect = 1e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 706
Query: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 707 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 766
Query: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 767 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 826
Query: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 879
Query: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 880 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 935
Query: 495 AWIKHVAQILESQ 507
AW ++ +L Q
Sbjct: 936 AWTADISHLLWRQ 948
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 1e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 495 AWIKHVAQILESQ 507
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 1e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 495 AWIKHVAQILESQ 507
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 1e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 495 AWIKHVAQILESQ 507
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 175 bits (444), Expect = 1e-43
Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)
Query: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
++L R VL+E+V TE+ YV L +E Y + VP+ LRG+ +FGN++++ +
Sbjct: 728 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787
Query: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
+H +FL+EL+ C + P +A F++H + MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847
Query: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
Q LG L L L+KP+QR+ KY LLL++ + + + L +A ++ F + ND
Sbjct: 848 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
++ + ++G + L QG+L+ QD F V + RR+FLFE++++FS+
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960
Query: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
G T + YK S K++ LGL RF + R + +VLQA+ AI Q
Sbjct: 961 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016
Query: 495 AWIKHVAQILESQ 507
AW ++ +L Q
Sbjct: 1017 AWTADISHLLWRQ 1029
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 156 bits (395), Expect = 5e-38
Identities = 108/407 (26%), Positives = 198/407 (48%), Gaps = 38/407 (9%)
Query: 186 PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM----AAQGVPESLRGR 241
PE E++ + L ++ +L+ETE++Y+ ++ I++GY+ M +P+ L+
Sbjct: 606 PELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNN 665
Query: 242 DRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHV 301
+FGNI+++YE+H FL+EL++C ++P+ LA F+K + L +Y Y +N P++ +
Sbjct: 666 KDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAI 725
Query: 302 VSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMD------ 354
E D +YF ++QL H L L L P QR++KYQ+LLK L + + M+
Sbjct: 726 WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGEL 785
Query: 355 ----------------TADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLL--G 396
+ +L+QA+ V+ + K C + L + + GKLL G
Sbjct: 786 GGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHG 845
Query: 397 QDTFWVTEPE---AGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKV 453
+ W + L+ + +R+++LFE+ I+F + G P Y +K ++K+
Sbjct: 846 PFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKL 905
Query: 454 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
L + +G +F + SR G+++Y+LQAA I W ++++L Q++ +
Sbjct: 906 MTLSIRQLGRGSHRKFEIASR---NGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962
Query: 514 LQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPING 560
+P Q S + G GP + + R + S+ I G
Sbjct: 963 QGNP---QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKG 1006
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 126 bits (317), Expect = 5e-29
Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%)
Query: 183 SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 235
++APE SE+E K R V+ EL+ +E+ +V++L + ++ + VP
Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730
Query: 236 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 295
++ G+ ++F N++ I +H FLQELQ+C D D +A FIK++ Y+ + +
Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788
Query: 296 PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 345
++E VV EF Y EE G Q L L +PV+R+ +YQ LLK+ +
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847
Query: 346 KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 405
+ R + A LEQA V+ +P+R + + + + + G L A G+ + Q F V E
Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907
Query: 406 EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 465
G + +G R VFLF ++ + R T YV++N +K+S + L ++GD
Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965
Query: 466 PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 503
F + E +++Y+LQA I +W+K + I
Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 126 bits (317), Expect = 5e-29
Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%)
Query: 183 SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 235
++APE SE+E K R V+ EL+ +E+ +V++L + ++ + VP
Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730
Query: 236 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 295
++ G+ ++F N++ I +H FLQELQ+C D D +A FIK++ Y+ + +
Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788
Query: 296 PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 345
++E VV EF Y EE G Q L L +PV+R+ +YQ LLK+ +
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847
Query: 346 KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 405
+ R + A LEQA V+ +P+R + + + + + G L A G+ + Q F V E
Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907
Query: 406 EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 465
G + +G R VFLF ++ + R T YV++N +K+S + L ++GD
Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965
Query: 466 PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 503
F + E +++Y+LQA I +W+K + I
Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 114 bits (285), Expect = 3e-25
Identities = 153/588 (26%), Positives = 238/588 (40%), Gaps = 94/588 (15%)
Query: 57 RRDREHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSG--PCSPGP-PGP 113
RR ++H + P Y ++G+ S A G P PS LSS P SPGP P P
Sbjct: 950 RRIQQH--VGEEASPRGYRRRRADGASSGGAQWG---PRSPSPSLSSLLLPSSPGPRPAP 1004
Query: 114 VSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPG-- 171
HC D + GP L P E P +L LE
Sbjct: 1005 -----------SHCSLAPCGEDYEEEGPE----LAPE---AEGRPPRAVLIRGLEVTSTE 1046
Query: 172 --DKTQPPEEETL---SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQ 220
D+T P E L ++ P+ + ++K+++ ++SEL+ E+ YV L +
Sbjct: 1047 VVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSE 1106
Query: 221 IVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIK 280
V + PE LRG +++ +HR +FL+ELQ C P + F++
Sbjct: 1107 PVP----PPGPELTPE-LRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLR 1161
Query: 281 HERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
H + +Y Y +++ K E+ ++ S + + G L L +P++++ +Y L
Sbjct: 1162 HGDQFSLYAQYVKHRHKLENGLAAL--SPLSKGSMEAGP--YLPRALQQPLEQLTRYGRL 1217
Query: 341 LKDFLKYYNRAGMDTAD----LEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLG 396
L++ L+ AG + + L AV+++ R D++ + +RG E L QG+LL
Sbjct: 1218 LEELLR---EAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLH 1274
Query: 397 QDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCL 456
+D F V + + R VFLFE +++FS+ G GG++ +VYK + K + +
Sbjct: 1275 RDPFTV-------ICGRKKCLRHVFLFEHLLLFSKL--KGPEGGSEM-FVYKQAFKTADM 1324
Query: 457 GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQS 516
GL N+ F L R + Y LQA P I W +AQ+L Q L
Sbjct: 1325 GLTENIGDSGLCFELWFRRRRAR-EAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKEL-- 1381
Query: 517 PIEYQRRESQTNSLGRPRGPGV---------------GSPGRIRLGDQAQGSTHTPINGS 561
R Q S+G P + G R R H S
Sbjct: 1382 ------RVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHA--GPS 1433
Query: 562 LPSL---LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPP 606
LP L S V LD + + P+ S VSP P+ P
Sbjct: 1434 LPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSP 1481
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 113 bits (282), Expect = 6e-25
Identities = 91/321 (28%), Positives = 155/321 (48%), Gaps = 41/321 (12%)
Query: 203 VLSELVETEKMYVDDLGQIVEGYMATMAAQG-VPESLRGRDRIVFGNIQQIYEWHRDYFL 261
V+ E++ETE+ YV DL IVE Y+ + Q +P R + FGNIQ IY ++ + L
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSAL-FGNIQDIYHFNSE-LL 174
Query: 262 QELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSE-----FGDSYFEELRQQ 316
Q+L+ C DP +A+ F+ H+Y YC N P+S V++E +F E ++
Sbjct: 175 QDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQET 234
Query: 317 LGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM 376
L H L L L+KPVQRI+KY LLL + + ++ + A++ M V NDM
Sbjct: 235 LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 294
Query: 377 -----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFE 424
L ++G LT+ G+L+ + TF + + ER +FLF+
Sbjct: 295 RKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAK---------NERTLFLFD 345
Query: 425 QIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS-RGPEGGIQRY 483
++++ ++ R T + YK I L L + +P F++ + P+ ++
Sbjct: 346 KLLLITKK-----RDDT---FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPK---LQH 394
Query: 484 VLQAADPAISQAWIKHVAQIL 504
+QA + W+ H+ +++
Sbjct: 395 TVQAKSQQDKRLWVLHLKRLI 415
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 104 bits (260), Expect = 2e-22
Identities = 114/376 (30%), Positives = 174/376 (46%), Gaps = 53/376 (14%)
Query: 203 VLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQ 262
V E+VETE+ YV DL IVE Y+ + GV + +F NI+ IYE+ + L+
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE-LLE 164
Query: 263 ELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS-----YFEELRQQL 317
+L+ +A+ F++ +Y +YC N P S ++ E S + +E + QL
Sbjct: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223
Query: 318 GHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTAD---LEQAVEVMCFVPKRCND 374
H L L L+KPVQRI+KY LLL++ K++ G T +E+A+ M V ND
Sbjct: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHW-AEGPGTGGREMVEEAIVSMTAVAWYIND 282
Query: 375 MM-----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 422
M RL G+ G +L+A G+L+ + F GG RG ER +FL
Sbjct: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF---RGGGGGGPRLRGGERLLFL 339
Query: 423 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRG-PEGGIQ 481
F ++++ ++ R G + Y YK I L + + + DP F ++ P+
Sbjct: 340 FSRMLLVAK------RRGLE--YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK---H 387
Query: 482 RYVLQAADPAISQAWI---------KHVAQILESQRDFL--NALQ-SPIEYQRRESQTNS 529
R++LQA + + WI H A I + L N+L +P E T
Sbjct: 388 RHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPP 447
Query: 530 LG--RPRGPGVGSPGR 543
LG RPR +PGR
Sbjct: 448 LGSPRPRDARSFTPGR 463
Score = 30.8 bits (68), Expect = 3.9
Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 12/110 (10%)
Query: 7 PAPGRTDRILGVMGGMLRA--CALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEV 64
P P +T +L GG L + L + P SP P S + G + +
Sbjct: 1228 PTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSP------PPSSRQLLGPNAAALSRYL 1281
Query: 65 LAGALQPESYSIAGSEG-SISASAASGLAAPSGPSSGLSSGPCSPGPPGP 113
A + S S+A +G A AAS + S P+S SS P P PP P
Sbjct: 1282 AASYI---SQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPP 1328
>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 85.1 bits (209), Expect = 2e-16
Identities = 99/402 (24%), Positives = 174/402 (43%), Gaps = 51/402 (12%)
Query: 65 LAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLD 122
+A P++ + S G + A A P S ++G SP GP G +SG + +
Sbjct: 14 IAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPN 73
Query: 123 HSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEE 179
S S AG EN+ E L G P T+L E D P P+E
Sbjct: 74 RDSGIDS----PSSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQE 124
Query: 180 ET---LSQAPESEEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYM 226
E + + P+SE +K ++ +++ EL+ TE+ YV L + + +
Sbjct: 125 EADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184
Query: 227 ATMAAQGVP-ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIK 280
+ G+P E + G +F NI I+ +H + L EL+ + + +W L + K
Sbjct: 185 TRLTDAGIPPEVIMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQK 239
Query: 281 HERRLHMYVVYCQNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQR 333
L MY Y +N ++ +VS F D +Q++ L L +++PVQR
Sbjct: 240 LAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQR 299
Query: 334 IMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLT 389
+ +Y+LLLKD+LK + D D E+++E++ N + + +L +L
Sbjct: 300 VPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLG 359
Query: 390 AQGKLLGQDTFWVTEPEAGGLLSSRG--RERRVFLFEQIIIF 429
+ ++ + E + L + G ++R +FLF +I++
Sbjct: 360 GEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401
>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
Length = 725
Score = 85.1 bits (209), Expect = 2e-16
Identities = 99/402 (24%), Positives = 174/402 (43%), Gaps = 51/402 (12%)
Query: 65 LAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLD 122
+A P++ + S G + A A P S ++G SP GP G +SG + +
Sbjct: 14 IAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPN 73
Query: 123 HSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEE 179
S S AG EN+ E L G P T+L E D P P+E
Sbjct: 74 RDSGIDS----PSSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQE 124
Query: 180 ET---LSQAPESEEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYM 226
E + + P+SE +K ++ +++ EL+ TE+ YV L + + +
Sbjct: 125 EADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184
Query: 227 ATMAAQGVP-ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIK 280
+ G+P E + G +F NI I+ +H + L EL+ + + +W L + K
Sbjct: 185 TRLTDAGIPPEVIMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQK 239
Query: 281 HERRLHMYVVYCQNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQR 333
L MY Y +N ++ +VS F D +Q++ L L +++PVQR
Sbjct: 240 LAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQR 299
Query: 334 IMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLT 389
+ +Y+LLLKD+LK + D D E+++E++ N + + +L +L
Sbjct: 300 VPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLG 359
Query: 390 AQGKLLGQDTFWVTEPEAGGLLSSRG--RERRVFLFEQIIIF 429
+ ++ + E + L + G ++R +FLF +I++
Sbjct: 360 GEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 77.4 bits (189), Expect = 4e-14
Identities = 75/267 (28%), Positives = 126/267 (47%), Gaps = 29/267 (10%)
Query: 180 ETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLR 239
E +S P+ E K+ L E+ +TE+ Y D LG I + ++ + P+ +
Sbjct: 181 EPVSMPPKMTEYDKRCCC------LREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIE 234
Query: 240 GRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW--LAQLFIKHERRLHMYVVYC-QNKP 296
I+F NI+ + H +FL+E++ L P L Q+FIK++ R +Y YC Q +
Sbjct: 235 ----IIFINIEDLLRVHT-HFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES 289
Query: 297 KSEHV-----VSEFGDSYFEELRQQLGH-RLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
S+H+ E EE Q+ + R L DLL+ P+QR++KY LLL++ +K+
Sbjct: 290 ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQE 349
Query: 351 AGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPE 406
A M+ +L A++ M + + N D TL ++ F+ + + L Q P+
Sbjct: 350 A-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSI----ENLDQSLAHYGRPK 404
Query: 407 AGGLLSSRGRERRVFLFEQIIIFSEAL 433
G L ERR + + +AL
Sbjct: 405 IDGELKITSVERRSKMDRYAFLLDKAL 431
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 77.0 bits (188), Expect = 5e-14
Identities = 98/409 (23%), Positives = 170/409 (41%), Gaps = 55/409 (13%)
Query: 170 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 229
P D P + ++ +E + K + + V++E++ TE+ Y+ L I EGY+
Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314
Query: 230 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 286
+ S + R +FGNI+ IY + + QR ++ L++L F++H+
Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373
Query: 287 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 340
+Y YC N P + +S +FE R Q + L+ L+ PVQ+I KY L
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433
Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 387
L + LKY + D D+E A+ M V + N+ + +EG+
Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493
Query: 388 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 444
L +L+ + VT+P+A + ++R FLF+ +I+ + L V
Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540
Query: 445 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 497
YK + + L G + +L RG G ++L P Q W+
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598
Query: 498 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPGVGSP 541
K A+ E + S E QR+++ N+ G+P+G +P
Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAP 647
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 75.9 bits (185), Expect = 1e-13
Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 31/214 (14%)
Query: 181 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM-----AAQGVP 235
TLS + E E+K ++ EL+ETE+ YV L + + + + +++ P
Sbjct: 93 TLSGSGTQEPEKK---------IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFP 143
Query: 236 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI-----KHERRLHMYVV 290
E + R++F NI IY++H +FL ELQR L D W A I K L MY
Sbjct: 144 EDVV---RVIFSNISSIYQFHSQFFLPELQRRLDD--WTANPRIGDVIQKLAPFLKMYSE 198
Query: 291 YCQNKPKSEHVVSEFGDS--YFEELRQQL-----GHRLQLNDLLIKPVQRIMKYQLLLKD 343
Y +N ++ +++ + D F+E+ ++ L L +++PVQRI +Y+LLLK+
Sbjct: 199 YVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKE 258
Query: 344 FLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMT 377
+++ D AD ++A++++ + N +T
Sbjct: 259 YIQKLPAQAPDQADAQKALDMIFSAAQHSNAAIT 292
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/405 (23%), Positives = 168/405 (41%), Gaps = 55/405 (13%)
Query: 170 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 229
P D P + ++ +E + K + + V++E++ TE+ Y+ L I EGY+
Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314
Query: 230 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 286
+ S + R +FGNI+ IY + + QR ++ L++L F++H+
Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373
Query: 287 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 340
+Y YC N P + +S +FE R Q + L+ L+ PVQ+I KY L
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433
Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 387
L + LKY + D D+E A+ M V + N+ + +EG+
Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493
Query: 388 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 444
L +L+ + VT+P+A + ++R FLF+ +I+ + L V
Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540
Query: 445 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 497
YK + + L G + +L RG G ++L P Q W+
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598
Query: 498 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPG 537
K A+ E + S E QR+++ N+ G+P+ G
Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVG 643
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 73.9 bits (180), Expect = 4e-13
Identities = 91/411 (22%), Positives = 163/411 (39%), Gaps = 76/411 (18%)
Query: 84 SASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYE 143
S S GL P+ PSS + SP P SGL + D S + A
Sbjct: 387 SISFPEGLRTPASPSSANAFYSLSPSTLVP-SGLPEFKDSSSSLTDPQVSYVKSPAAERR 445
Query: 144 NWMLEPALATGEELPELTLL--TTLLEGPGDKTQPPEEETLS-----------QAPESEE 190
+ A+A G + P L L GPG T+ P+ S Q P
Sbjct: 446 SG----AVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPA 501
Query: 191 EQ-------------------------KKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
EQ K+ + + +++ E++ TE+ Y+ DL I +
Sbjct: 502 EQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWF 561
Query: 226 MATMAAQ-GVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLK------------DPD 272
+ + + +P +L ++F NI IYE+HR FL+E+++ L
Sbjct: 562 RSAVVKEDAMPATLM---TLLFSNIDPIYEFHRG-FLREVEQRLALWEGPSKAHTKGSHQ 617
Query: 273 WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFG---------DSYFEELRQQLGHRLQL 323
+ + +++ R+L + Y Q + + V++E ++ ++E Q L L
Sbjct: 618 RIGDILLRNMRQLKEFTSYFQ---RHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPL 674
Query: 324 NDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM----TLG 379
N L+KP+QR++ Y+LLL+ +Y+ D AD A++ + V ++ L
Sbjct: 675 NTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQ 734
Query: 380 RLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFS 430
+L + L L+ ++ E L ++R FLF +++++
Sbjct: 735 KLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYT 785
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 72.0 bits (175), Expect = 2e-12
Identities = 55/221 (24%), Positives = 108/221 (48%), Gaps = 14/221 (6%)
Query: 167 LEGPGDKTQPPEEETLSQAP--ESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEG 224
LE D+ + E++ P E +E + ++ ++ +EL++TEK YV L + +
Sbjct: 339 LEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQV 398
Query: 225 YMATMAAQGVPESLRGRDRI--VFGNIQQIYEWHRDYFLQELQRCLKDPDW---LAQLFI 279
+ A + + S D + +F NI IY +H+ + L EL++ +++ D + +
Sbjct: 399 FCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQ 458
Query: 280 KHERRLHMYVVYCQNKPKSEHVVS-------EFGDSYFEELRQQLGHRLQLNDLLIKPVQ 332
K L MY Y +N ++ +V+ +F E +++ L L +++PVQ
Sbjct: 459 KLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQ 518
Query: 333 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN 373
RI +Y+LLLKD+L D+ D ++++E++ + N
Sbjct: 519 RIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSN 559
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,890,030
Number of Sequences: 37866
Number of extensions: 1580027
Number of successful extensions: 9155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 8025
Number of HSP's gapped (non-prelim): 1267
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.