Guide to the Human Genome
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Search of human proteins with 162287076

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
         (619 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi...  1255   0.0  
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi...  1108   0.0  
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...   461   e-130
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]          430   e-120
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]           430   e-120
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]            231   1e-60
gi|148529025 pleckstrin homology domain containing, family G (wi...   197   2e-50
gi|163644325 MCF.2 cell line derived transforming sequence-like ...   192   8e-49
gi|163644323 MCF.2 cell line derived transforming sequence-like ...   192   8e-49
gi|153791628 MCF.2 cell line derived transforming sequence isofo...   184   3e-46
gi|153791325 MCF.2 cell line derived transforming sequence isofo...   184   3e-46
gi|193211603 pleckstrin homology domain containing, family G (wi...   175   1e-43
gi|193211598 pleckstrin homology domain containing, family G (wi...   175   1e-43
gi|193211596 pleckstrin homology domain containing, family G (wi...   175   1e-43
gi|193211594 pleckstrin homology domain containing, family G (wi...   175   1e-43
gi|55742734 pleckstrin homology domain containing, family G (wit...   175   1e-43
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ...   156   5e-38
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact...   126   5e-29
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac...   126   5e-29
gi|50843837 hypothetical protein LOC55701 [Homo sapiens]              114   3e-25
gi|71274148 pleckstrin homology domain containing, family G (wit...   113   6e-25
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...   104   2e-22
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    85   2e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    85   2e-16
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     77   4e-14
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    77   5e-14
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    76   1e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    75   2e-13
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...    74   4e-13
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              72   2e-12

>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
           sapiens]
          Length = 619

 Score = 1255 bits (3247), Expect = 0.0
 Identities = 619/619 (100%), Positives = 619/619 (100%)

Query: 1   MKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDR 60
           MKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDR
Sbjct: 1   MKPPDRPAPGRTDRILGVMGGMLRACALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDR 60

Query: 61  EHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRW 120
           EHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRW
Sbjct: 61  EHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRW 120

Query: 121 LDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEE 180
           LDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEE
Sbjct: 121 LDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEE 180

Query: 181 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG 240
           TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG
Sbjct: 181 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRG 240

Query: 241 RDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEH 300
           RDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEH
Sbjct: 241 RDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEH 300

Query: 301 VVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQ 360
           VVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQ
Sbjct: 301 VVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQ 360

Query: 361 AVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV 420
           AVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV
Sbjct: 361 AVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRV 420

Query: 421 FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGI 480
           FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGI
Sbjct: 421 FLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGI 480

Query: 481 QRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGS 540
           QRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGS
Sbjct: 481 QRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGS 540

Query: 541 PGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSP 600
           PGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSP
Sbjct: 541 PGRIRLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSP 600

Query: 601 TPKTPPCQARLAKLDEDEL 619
           TPKTPPCQARLAKLDEDEL
Sbjct: 601 TPKTPPCQARLAKLDEDEL 619


>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
           sapiens]
          Length = 580

 Score = 1108 bits (2866), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 72  ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 131
           ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE
Sbjct: 33  ESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVE 92

Query: 132 TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 191
           TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE
Sbjct: 93  TEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEE 152

Query: 192 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 251
           QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ
Sbjct: 153 QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQ 212

Query: 252 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 311
           IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE
Sbjct: 213 IYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFE 272

Query: 312 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 371
           ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR
Sbjct: 273 ELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKR 332

Query: 372 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 431
           CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE
Sbjct: 333 CNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSE 392

Query: 432 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 491
           ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA
Sbjct: 393 ALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPA 452

Query: 492 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 551
           ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ
Sbjct: 453 ISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQ 512

Query: 552 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 611
           GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL
Sbjct: 513 GSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARL 572

Query: 612 AKLDEDEL 619
           AKLDEDEL
Sbjct: 573 AKLDEDEL 580


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score =  461 bits (1186), Expect = e-130
 Identities = 273/581 (46%), Positives = 364/581 (62%), Gaps = 34/581 (5%)

Query: 51   RTEGDHRRDREHEVLAGALQPESYSIAG-----SEGSISASAASGLAAPSGPSSGLSSGP 105
            R   D    ++ +  A   Q E+    G     S G++S S++SG+ +  G   G     
Sbjct: 1807 RKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQS-CGEEEGEEGAD 1865

Query: 106  CSPGPPGPVSGLRRWLDH-------SKHCLSVETEADSGQAGPYENWMLEPALATGEELP 158
              P PP         L         S   L   T +++  A    +  +E  + +   L 
Sbjct: 1866 AVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVS-AIEELVKSKMALE 1924

Query: 159  ELTLLTTLLEGPGDKTQP---PEEETL--SQAPESE-EEQKKKALERSMYVLSELVETEK 212
            +    ++LL   GD + P   P + +L  S +P  E EE+K  +L+R  YVL ELVETE+
Sbjct: 1925 DRP--SSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETER 1982

Query: 213  MYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPD 272
             YV DLG +VEGYMA M   GVP+ ++G+D+IVFGNI QIY+WHRD+FL EL++CL+DP+
Sbjct: 1983 DYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPE 2042

Query: 273  WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQ 332
             L  LF+KHERRLHMY+ YCQNKPKSEH+VSE+ D++FE+L+Q+LGHRLQL DLLIKPVQ
Sbjct: 2043 KLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQ 2102

Query: 333  RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQG 392
            RIMKYQLLLKDFLKY  +A +DT++LE+AVEVMC VP+RCNDMM +GRL+GF+GK+ AQG
Sbjct: 2103 RIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQG 2162

Query: 393  KLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIK 452
            KLL QDTF VT+ +AG  L  R RERR+FLFEQI+IFSE L    +G + PG+++KNSIK
Sbjct: 2163 KLLLQDTFLVTDQDAG--LLPRCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIK 2219

Query: 453  VSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLN 512
            VSCL LE N++ DPC+FALTSR  +  ++ ++L ++ P++ Q WI  + QILE+QR+FLN
Sbjct: 2220 VSCLCLEENVENDPCKFALTSRTGD-VVETFILHSSSPSVRQTWIHEINQILENQRNFLN 2278

Query: 513  ALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHT--PIN-GSLPSLLLSP 569
            AL SPIEYQR  S     G   G G G  G    G  + GS H+  P + G  PS   S 
Sbjct: 2279 ALTSPIEYQRNHSGGGGGGGSGGSG-GGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSR 2337

Query: 570  KGEVARALL----PLDKQALGDIPQAPHDSPPVSPTPKTPP 606
               + + +      L   A     +A   S   +P P  PP
Sbjct: 2338 PSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPP 2378



 Score =  236 bits (601), Expect = 6e-62
 Identities = 131/370 (35%), Positives = 212/370 (57%), Gaps = 12/370 (3%)

Query: 176  PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQG 233
            P  E  L  A     E+K+K+  R  ++++EL++TEK YV DL + ++ Y+   T   + 
Sbjct: 1269 PGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE 1328

Query: 234  VPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQ 293
            +P  +  ++ I+FGN+Q+IYE+H + FL+EL++  + P+ +   F+    +  MYV YC+
Sbjct: 1329 IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCK 1388

Query: 294  NKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM 353
            NKP S  ++ E   SYF+E++Q+ G    ++  LIKPVQRI KYQLLLK+ L        
Sbjct: 1389 NKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG-- 1446

Query: 354  DTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSS 413
               +++  +EVM  VPKR ND M L  L GF+  + +QG+L+ Q++F V +P+    L  
Sbjct: 1447 -KGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT---LIR 1502

Query: 414  RGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS 473
            +GRER +FLFE  ++FS+ +        +  Y+YK+ +  S LG+  +++GDPC+FAL  
Sbjct: 1503 KGRERHLFLFEMSLVFSKEVKD---SSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV 1559

Query: 474  RGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEYQRRESQTNSLGR 532
                    + VL+A+     Q WIKH+ ++++ +   L  AL+ PI   +    T   GR
Sbjct: 1560 GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR 1619

Query: 533  PRGPGVGSPG 542
              G  + S G
Sbjct: 1620 RDGEDLDSQG 1629


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score =  430 bits (1106), Expect = e-120
 Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)

Query: 189  EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 248
            EEEQK KAL   M+VL+ELV+TEK YV DLG +VEG+M  +  +GVPE +RG+D+IVFGN
Sbjct: 1919 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 1978

Query: 249  IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 308
            I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 1979 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 2037

Query: 309  YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 368
            YFEE++Q++  RL L+D LIKP+QRI KYQLLLKDFL+Y  +AG++ +D+E+AVE+MC V
Sbjct: 2038 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097

Query: 369  PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 428
            PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG  + SR +ERRVFLFEQI+I
Sbjct: 2098 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 2155

Query: 429  FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 488
            FSE L    +G   PGY++K SIK++ L LE N+  DPC+FAL +R      +R VLQAA
Sbjct: 2156 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 2209

Query: 489  DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 527
            +  I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E  T
Sbjct: 2210 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 2248



 Score =  231 bits (589), Expect = 1e-60
 Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)

Query: 179  EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 236
            E  L  A     E+K+K+  +  ++++EL++TEK YV DL + +E Y+   T   + +P 
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320

Query: 237  SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 296
             +  ++ I+FGNIQ+IY++H + FL+EL++  + P+ +   F+    +  MYV YC+NKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380

Query: 297  KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 356
             S  ++ E   ++F+E++Q+ G    ++  LIKPVQRI KYQLLLK+ L           
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437

Query: 357  DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 416
            +L+  +EVM  VPK+ ND M +  L GF+  L  QG+L+ QD F V +P++   L  +GR
Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494

Query: 417  ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 476
            ER +FLFE  ++FS+ +     G T+  YVYKN +  S LG+  +++GDPC+FAL S   
Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551

Query: 477  EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 529
                 + VL+A++    Q WIK++ ++++ +   L  AL+ P++       QR  S+ + 
Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611

Query: 530  LG--RPRGPGVGSPGRIRLGDQAQGST 554
            +     +G G   P  I +  +   +T
Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score =  430 bits (1106), Expect = e-120
 Identities = 212/339 (62%), Positives = 274/339 (80%), Gaps = 9/339 (2%)

Query: 189 EEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGN 248
           EEEQK KAL   M+VL+ELV+TEK YV DLG +VEG+M  +  +GVPE +RG+D+IVFGN
Sbjct: 222 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 281

Query: 249 IQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS 308
           I QIY+WH+D+FL EL++C+++ D LAQLFIKHER+LH+YV YCQNKP+SE++V+E+ D+
Sbjct: 282 IHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY-DA 340

Query: 309 YFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFV 368
           YFEE++Q++  RL L+D LIKP+QRI KYQLLLKDFL+Y  +AG++ +D+E+AVE+MC V
Sbjct: 341 YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400

Query: 369 PKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIII 428
           PKRCNDMM LGRL+GFEG LTAQGKLL QDTF+V E +AG  + SR +ERRVFLFEQI+I
Sbjct: 401 PKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAG--MQSRTKERRVFLFEQIVI 458

Query: 429 FSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAA 488
           FSE L    +G   PGY++K SIK++ L LE N+  DPC+FAL +R      +R VLQAA
Sbjct: 459 FSELLR---KGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETS---ERVVLQAA 512

Query: 489 DPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQT 527
           +  I QAW++ + Q+LE+QRDFLNALQSPIEYQR+E  T
Sbjct: 513 NADIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERST 551


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score =  231 bits (589), Expect = 1e-60
 Identities = 134/387 (34%), Positives = 222/387 (57%), Gaps = 20/387 (5%)

Query: 179  EETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYM--ATMAAQGVPE 236
            E  L  A     E+K+K+  +  ++++EL++TEK YV DL + +E Y+   T   + +P 
Sbjct: 1261 EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP 1320

Query: 237  SLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKP 296
             +  ++ I+FGNIQ+IY++H + FL+EL++  + P+ +   F+    +  MYV YC+NKP
Sbjct: 1321 GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP 1380

Query: 297  KSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTA 356
             S  ++ E   ++F+E++Q+ G    ++  LIKPVQRI KYQLLLK+ L           
Sbjct: 1381 DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEG---KG 1437

Query: 357  DLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGR 416
            +L+  +EVM  VPK+ ND M +  L GF+  L  QG+L+ QD F V +P++   L  +GR
Sbjct: 1438 ELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKS---LIRKGR 1494

Query: 417  ERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGP 476
            ER +FLFE  ++FS+ +     G T+  YVYKN +  S LG+  +++GDPC+FAL S   
Sbjct: 1495 ERHLFLFEISLVFSKEIKDS-SGHTK--YVYKNKLLTSELGVTEHVEGDPCKFALWSGRT 1551

Query: 477  EGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL-NALQSPIEY------QRRESQTNS 529
                 + VL+A++    Q WIK++ ++++ +   L  AL+ P++       QR  S+ + 
Sbjct: 1552 PSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDG 1611

Query: 530  LG--RPRGPGVGSPGRIRLGDQAQGST 554
            +     +G G   P  I +  +   +T
Sbjct: 1612 VEDIDSQGDGSSQPDTISIASRTSQNT 1638


>gi|148529025 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4B [Homo sapiens]
          Length = 1271

 Score =  197 bits (501), Expect = 2e-50
 Identities = 115/375 (30%), Positives = 204/375 (54%), Gaps = 21/375 (5%)

Query: 186  PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIV 245
            P  E+ +++    R  ++++E++ TE+ Y+  LG +++ Y   M    +P+ LRG+  ++
Sbjct: 792  PAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVI 851

Query: 246  FGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEF 305
            FGN+++++++H+ +FL+EL+RC   P  + + F++HE +  MYV+Y +NKP+S+ ++S  
Sbjct: 852  FGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSH 911

Query: 306  GDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYN---RAGMDTADLEQAV 362
            G+++F++ +++LG ++ L   L++PVQR+ KY LLL+D LK  +     G +  +L  A 
Sbjct: 912  GNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAE 971

Query: 363  EVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 422
             V+CF  +  ND++ +  +RG +  L  QG+L  +D F V           +   R VFL
Sbjct: 972  VVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIV-------CCGRKKYLRHVFL 1024

Query: 423  FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQR 482
            FE +I+FS+        G+   Y+YK S K + +G+  N+     RF +  R        
Sbjct: 1025 FEDLILFSKT---QKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDT 1081

Query: 483  YVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPG 542
            Y+LQA+   +  AW   + +IL  Q     AL+S    + R  +  S+G    P +    
Sbjct: 1082 YILQASSAEVKSAWTDVIGRILWRQ-----ALKS---RELRIQEMASMGIGNQPFMDVKP 1133

Query: 543  RIRLGDQAQGSTHTP 557
            R R  D A  S   P
Sbjct: 1134 RDRTPDCAVISDRAP 1148


>gi|163644325 MCF.2 cell line derived transforming sequence-like
            isoform a [Homo sapiens]
          Length = 1182

 Score =  192 bits (488), Expect = 8e-49
 Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)

Query: 166  LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
            L  GP  + +    E+      + EE++  A+ R  +V+SEL++TE+ YV++L  ++EGY
Sbjct: 626  LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 684

Query: 226  MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 281
             A M     A  +   L  +  ++FGN+++IY +H   FL+EL+     P+ + + F++ 
Sbjct: 685  AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 744

Query: 282  ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
                 +Y  YCQNKP+SE +  +  D  +F+E +++L H+L L+  L+KPVQRI KYQLL
Sbjct: 745  MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 804

Query: 341  LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 400
            LK+ LK Y+R      DL++A+  +  + K  ND M L  + G++G L   GKLL Q +F
Sbjct: 805  LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 863

Query: 401  WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 453
             V      G      L   +  +R +FL E+ ++F +       G  + P Y YK S+ +
Sbjct: 864  SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 923

Query: 454  SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
            + +G+  N++GD  +F +     E   + Y++QA  P I  AW+  + ++L SQ   L A
Sbjct: 924  AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 977

Query: 514  LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 543
             +   +++  E Q+ SL  P  P   SP R
Sbjct: 978  CREASQHRALE-QSQSLPLP-APTSTSPSR 1005


>gi|163644323 MCF.2 cell line derived transforming sequence-like
           isoform b [Homo sapiens]
          Length = 1129

 Score =  192 bits (488), Expect = 8e-49
 Identities = 128/390 (32%), Positives = 211/390 (54%), Gaps = 22/390 (5%)

Query: 166 LLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
           L  GP  + +    E+      + EE++  A+ R  +V+SEL++TE+ YV++L  ++EGY
Sbjct: 573 LRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR-HVMSELLDTERAYVEELLCVLEGY 631

Query: 226 MATM----AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKH 281
            A M     A  +   L  +  ++FGN+++IY +H   FL+EL+     P+ + + F++ 
Sbjct: 632 AAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLER 691

Query: 282 ERRLHMYVVYCQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
                +Y  YCQNKP+SE +  +  D  +F+E +++L H+L L+  L+KPVQRI KYQLL
Sbjct: 692 MEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLL 751

Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF 400
           LK+ LK Y+R      DL++A+  +  + K  ND M L  + G++G L   GKLL Q +F
Sbjct: 752 LKEMLK-YSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSF 810

Query: 401 WVTEPEAGG------LLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQ-PGYVYKNSIKV 453
            V      G      L   +  +R +FL E+ ++F +       G  + P Y YK S+ +
Sbjct: 811 SVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNM 870

Query: 454 SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
           + +G+  N++GD  +F +     E   + Y++QA  P I  AW+  + ++L SQ   L A
Sbjct: 871 AAVGITENVKGDAKKFEIWYNARE---EVYIVQAPTPEIKAAWVNEIRKVLTSQ---LQA 924

Query: 514 LQSPIEYQRRESQTNSLGRPRGPGVGSPGR 543
            +   +++  E Q+ SL  P  P   SP R
Sbjct: 925 CREASQHRALE-QSQSLPLP-APTSTSPSR 952


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score =  184 bits (466), Expect = 3e-46
 Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)

Query: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 234
           P  +E  S  P S  +          +VL+EL++TE++YV +L  ++ GY A M    + 
Sbjct: 532 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 591

Query: 235 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 291
              P  LR +  I+FGN+ +IYE+H D FL  L+ C   P+ +   F++ +    MY  Y
Sbjct: 592 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 651

Query: 292 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
           CQNKP+SE +  ++ + ++F+E +++L HRL+L+  L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 652 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 710

Query: 351 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 408
               +A L++A++ M  + K  ND M    + G+ G L   GK++ Q  F  W+   +  
Sbjct: 711 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 770

Query: 409 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 463
             +    R    +R +FL+E+ I+F    +  G      P Y +K+  K+  +G+   ++
Sbjct: 771 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 830

Query: 464 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 511
           GD  +F +     E   + Y++QA++  +   W+K +  IL  Q++ L
Sbjct: 831 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 875


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score =  184 bits (466), Expect = 3e-46
 Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)

Query: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 234
           P  +E  S  P S  +          +VL+EL++TE++YV +L  ++ GY A M    + 
Sbjct: 472 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 531

Query: 235 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 291
              P  LR +  I+FGN+ +IYE+H D FL  L+ C   P+ +   F++ +    MY  Y
Sbjct: 532 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 591

Query: 292 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
           CQNKP+SE +  ++ + ++F+E +++L HRL+L+  L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 592 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 650

Query: 351 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 408
               +A L++A++ M  + K  ND M    + G+ G L   GK++ Q  F  W+   +  
Sbjct: 651 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 710

Query: 409 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 463
             +    R    +R +FL+E+ I+F    +  G      P Y +K+  K+  +G+   ++
Sbjct: 711 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 770

Query: 464 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 511
           GD  +F +     E   + Y++QA++  +   W+K +  IL  Q++ L
Sbjct: 771 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 815


>gi|193211603 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4 isoform 2 [Homo sapiens]
          Length = 1110

 Score =  175 bits (444), Expect = 1e-43
 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)

Query: 195 KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
           ++L R   VL+E+V TE+ YV  L   +E Y   +    VP+ LRG+   +FGN++++ +
Sbjct: 647 RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 706

Query: 255 WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
           +H  +FL+EL+ C + P  +A  F++H  +  MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 707 FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 766

Query: 315 QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
           Q LG  L L   L+KP+QR+ KY LLL++  +       + + L +A  ++ F  +  ND
Sbjct: 767 QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 826

Query: 375 MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
           ++ +  ++G +  L  QG+L+ QD F V       +       RR+FLFE++++FS+   
Sbjct: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 879

Query: 435 GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
           G     T   + YK S K++ LGL         RF +  R  +     +VLQA+  AI Q
Sbjct: 880 GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 935

Query: 495 AWIKHVAQILESQ 507
           AW   ++ +L  Q
Sbjct: 936 AWTADISHLLWRQ 948


>gi|193211598 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  175 bits (444), Expect = 1e-43
 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)

Query: 195  KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
            ++L R   VL+E+V TE+ YV  L   +E Y   +    VP+ LRG+   +FGN++++ +
Sbjct: 728  RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787

Query: 255  WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
            +H  +FL+EL+ C + P  +A  F++H  +  MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788  FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847

Query: 315  QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
            Q LG  L L   L+KP+QR+ KY LLL++  +       + + L +A  ++ F  +  ND
Sbjct: 848  QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907

Query: 375  MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
            ++ +  ++G +  L  QG+L+ QD F V       +       RR+FLFE++++FS+   
Sbjct: 908  LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960

Query: 435  GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
            G     T   + YK S K++ LGL         RF +  R  +     +VLQA+  AI Q
Sbjct: 961  GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016

Query: 495  AWIKHVAQILESQ 507
            AW   ++ +L  Q
Sbjct: 1017 AWTADISHLLWRQ 1029


>gi|193211596 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  175 bits (444), Expect = 1e-43
 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)

Query: 195  KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
            ++L R   VL+E+V TE+ YV  L   +E Y   +    VP+ LRG+   +FGN++++ +
Sbjct: 728  RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787

Query: 255  WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
            +H  +FL+EL+ C + P  +A  F++H  +  MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788  FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847

Query: 315  QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
            Q LG  L L   L+KP+QR+ KY LLL++  +       + + L +A  ++ F  +  ND
Sbjct: 848  QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907

Query: 375  MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
            ++ +  ++G +  L  QG+L+ QD F V       +       RR+FLFE++++FS+   
Sbjct: 908  LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960

Query: 435  GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
            G     T   + YK S K++ LGL         RF +  R  +     +VLQA+  AI Q
Sbjct: 961  GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016

Query: 495  AWIKHVAQILESQ 507
            AW   ++ +L  Q
Sbjct: 1017 AWTADISHLLWRQ 1029


>gi|193211594 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  175 bits (444), Expect = 1e-43
 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)

Query: 195  KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
            ++L R   VL+E+V TE+ YV  L   +E Y   +    VP+ LRG+   +FGN++++ +
Sbjct: 728  RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787

Query: 255  WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
            +H  +FL+EL+ C + P  +A  F++H  +  MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788  FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847

Query: 315  QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
            Q LG  L L   L+KP+QR+ KY LLL++  +       + + L +A  ++ F  +  ND
Sbjct: 848  QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907

Query: 375  MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
            ++ +  ++G +  L  QG+L+ QD F V       +       RR+FLFE++++FS+   
Sbjct: 908  LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960

Query: 435  GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
            G     T   + YK S K++ LGL         RF +  R  +     +VLQA+  AI Q
Sbjct: 961  GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016

Query: 495  AWIKHVAQILESQ 507
            AW   ++ +L  Q
Sbjct: 1017 AWTADISHLLWRQ 1029


>gi|55742734 pleckstrin homology domain containing, family G (with
            RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  175 bits (444), Expect = 1e-43
 Identities = 101/313 (32%), Positives = 174/313 (55%), Gaps = 11/313 (3%)

Query: 195  KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYE 254
            ++L R   VL+E+V TE+ YV  L   +E Y   +    VP+ LRG+   +FGN++++ +
Sbjct: 728  RSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRD 787

Query: 255  WHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELR 314
            +H  +FL+EL+ C + P  +A  F++H  +  MY +Y +NKP+S+ ++S +G ++F++ +
Sbjct: 788  FHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQ 847

Query: 315  QQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND 374
            Q LG  L L   L+KP+QR+ KY LLL++  +       + + L +A  ++ F  +  ND
Sbjct: 848  QALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGND 907

Query: 375  MMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALG 434
            ++ +  ++G +  L  QG+L+ QD F V       +       RR+FLFE++++FS+   
Sbjct: 908  LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------RRIFLFEELLLFSKPRH 960

Query: 435  GGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQ 494
            G     T   + YK S K++ LGL         RF +  R  +     +VLQA+  AI Q
Sbjct: 961  GPTGVDT---FAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKAR-DTFVLQASSLAIKQ 1016

Query: 495  AWIKHVAQILESQ 507
            AW   ++ +L  Q
Sbjct: 1017 AWTADISHLLWRQ 1029


>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
            sapiens]
          Length = 1114

 Score =  156 bits (395), Expect = 5e-38
 Identities = 108/407 (26%), Positives = 198/407 (48%), Gaps = 38/407 (9%)

Query: 186  PESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM----AAQGVPESLRGR 241
            PE E++ +   L     ++ +L+ETE++Y+ ++  I++GY+  M        +P+ L+  
Sbjct: 606  PELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNN 665

Query: 242  DRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHV 301
               +FGNI+++YE+H   FL+EL++C ++P+ LA  F+K +  L +Y  Y +N P++  +
Sbjct: 666  KDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAI 725

Query: 302  VSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMD------ 354
              E  D +YF   ++QL H L L   L  P QR++KYQ+LLK  L + +   M+      
Sbjct: 726  WQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGEL 785

Query: 355  ----------------TADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLL--G 396
                            + +L+QA+ V+  + K C   + L  +      +   GKLL  G
Sbjct: 786  GGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHG 845

Query: 397  QDTFWVTEPE---AGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKV 453
              + W    +      L+  +  +R+++LFE+ I+F +        G  P Y +K ++K+
Sbjct: 846  PFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKL 905

Query: 454  SCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNA 513
              L +    +G   +F + SR    G+++Y+LQAA   I   W   ++++L  Q++ +  
Sbjct: 906  MTLSIRQLGRGSHRKFEIASR---NGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKD 962

Query: 514  LQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPING 560
              +P   Q   S +   G   GP + +  R     +   S+   I G
Sbjct: 963  QGNP---QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKG 1006


>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform a [Homo sapiens]
          Length = 6620

 Score =  126 bits (317), Expect = 5e-29
 Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%)

Query: 183  SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 235
            ++APE      SE+E K     R   V+ EL+ +E+ +V++L  +   ++  +     VP
Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730

Query: 236  ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 295
             ++ G+  ++F N++ I  +H   FLQELQ+C  D D +A  FIK++     Y+ +   +
Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788

Query: 296  PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 345
             ++E VV      EF   Y EE     G   Q     L   L +PV+R+ +YQ LLK+ +
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847

Query: 346  KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 405
            +   R   + A LEQA  V+  +P+R  + + +  +  + G L A G+ + Q  F V E 
Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907

Query: 406  EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 465
              G  +  +G  R VFLF   ++  +      R  T   YV++N +K+S + L   ++GD
Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965

Query: 466  PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 503
               F +     E  +++Y+LQA    I  +W+K +  I
Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002


>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
            RhoGEF isoform b [Homo sapiens]
          Length = 7968

 Score =  126 bits (317), Expect = 5e-29
 Identities = 99/338 (29%), Positives = 168/338 (49%), Gaps = 27/338 (7%)

Query: 183  SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMA-AQGVP 235
            ++APE      SE+E K     R   V+ EL+ +E+ +V++L  +   ++  +     VP
Sbjct: 5675 AEAPEFPGEAVSEDEYKA----RLSSVIQELLSSEQAFVEELQFLQSHHLQHLERCPHVP 5730

Query: 236  ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNK 295
             ++ G+  ++F N++ I  +H   FLQELQ+C  D D +A  FIK++     Y+ +   +
Sbjct: 5731 IAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDDD-VAMCFIKNQAAFEQYLEFLVGR 5788

Query: 296  PKSEHVV-----SEFGDSYFEELRQQLGHRLQ-----LNDLLIKPVQRIMKYQLLLKDFL 345
             ++E VV      EF   Y EE     G   Q     L   L +PV+R+ +YQ LLK+ +
Sbjct: 5789 VQAESVVVSTAIQEFYKKYAEEALLA-GDPSQPPPPPLQHYLEQPVERVQRYQALLKELI 5847

Query: 346  KYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEP 405
            +   R   + A LEQA  V+  +P+R  + + +  +  + G L A G+ + Q  F V E 
Sbjct: 5848 RNKARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG 5907

Query: 406  EAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGD 465
              G  +  +G  R VFLF   ++  +      R  T   YV++N +K+S + L   ++GD
Sbjct: 5908 APGARMPWKGHNRHVFLFRNHLVICKPRRDS-RTDT-VSYVFRNMMKLSSIDLNDQVEGD 5965

Query: 466  PCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQI 503
               F +     E  +++Y+LQA    I  +W+K +  I
Sbjct: 5966 DRAFEVWQE-REDSVRKYLLQARTAIIKSSWVKEICGI 6002


>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
          Length = 1519

 Score =  114 bits (285), Expect = 3e-25
 Identities = 153/588 (26%), Positives = 238/588 (40%), Gaps = 94/588 (15%)

Query: 57   RRDREHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSG--PCSPGP-PGP 113
            RR ++H  +     P  Y    ++G+ S  A  G   P  PS  LSS   P SPGP P P
Sbjct: 950  RRIQQH--VGEEASPRGYRRRRADGASSGGAQWG---PRSPSPSLSSLLLPSSPGPRPAP 1004

Query: 114  VSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPG-- 171
                        HC       D  + GP     L P     E  P   +L   LE     
Sbjct: 1005 -----------SHCSLAPCGEDYEEEGPE----LAPE---AEGRPPRAVLIRGLEVTSTE 1046

Query: 172  --DKTQPPEEETL---SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQ 220
              D+T  P E  L   ++ P+      +   ++K+++     ++SEL+  E+ YV  L +
Sbjct: 1047 VVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSE 1106

Query: 221  IVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIK 280
             V         +  PE LRG         +++  +HR +FL+ELQ C   P  +   F++
Sbjct: 1107 PVP----PPGPELTPE-LRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLR 1161

Query: 281  HERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
            H  +  +Y  Y +++ K E+ ++    S   +   + G    L   L +P++++ +Y  L
Sbjct: 1162 HGDQFSLYAQYVKHRHKLENGLAAL--SPLSKGSMEAGP--YLPRALQQPLEQLTRYGRL 1217

Query: 341  LKDFLKYYNRAGMDTAD----LEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLG 396
            L++ L+    AG + +     L  AV+++     R  D++ +  +RG E  L  QG+LL 
Sbjct: 1218 LEELLR---EAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLH 1274

Query: 397  QDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCL 456
            +D F V       +   +   R VFLFE +++FS+    G  GG++  +VYK + K + +
Sbjct: 1275 RDPFTV-------ICGRKKCLRHVFLFEHLLLFSKL--KGPEGGSEM-FVYKQAFKTADM 1324

Query: 457  GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQS 516
            GL  N+      F L  R      + Y LQA  P I   W   +AQ+L  Q      L  
Sbjct: 1325 GLTENIGDSGLCFELWFRRRRAR-EAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKEL-- 1381

Query: 517  PIEYQRRESQTNSLGRPRGPGV---------------GSPGRIRLGDQAQGSTHTPINGS 561
                  R  Q  S+G    P +               G   R R         H     S
Sbjct: 1382 ------RVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHA--GPS 1433

Query: 562  LPSL---LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPP 606
            LP L     S    V      LD + +   P+    S  VSP P+  P
Sbjct: 1434 LPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSP 1481


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  113 bits (282), Expect = 6e-25
 Identities = 91/321 (28%), Positives = 155/321 (48%), Gaps = 41/321 (12%)

Query: 203 VLSELVETEKMYVDDLGQIVEGYMATMAAQG-VPESLRGRDRIVFGNIQQIYEWHRDYFL 261
           V+ E++ETE+ YV DL  IVE Y+  +  Q  +P     R  + FGNIQ IY ++ +  L
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSAL-FGNIQDIYHFNSE-LL 174

Query: 262 QELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSE-----FGDSYFEELRQQ 316
           Q+L+ C  DP  +A+ F+      H+Y  YC N P+S  V++E         +F E ++ 
Sbjct: 175 QDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQET 234

Query: 317 LGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM 376
           L H L L   L+KPVQRI+KY LLL +   + ++       +  A++ M  V    NDM 
Sbjct: 235 LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMK 294

Query: 377 -----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFE 424
                          L  ++G  LT+ G+L+ + TF +   +          ER +FLF+
Sbjct: 295 RKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAK---------NERTLFLFD 345

Query: 425 QIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTS-RGPEGGIQRY 483
           ++++ ++      R  T   + YK  I    L L   +  +P  F++   + P+    ++
Sbjct: 346 KLLLITKK-----RDDT---FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPK---LQH 394

Query: 484 VLQAADPAISQAWIKHVAQIL 504
            +QA      + W+ H+ +++
Sbjct: 395 TVQAKSQQDKRLWVLHLKRLI 415


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score =  104 bits (260), Expect = 2e-22
 Identities = 114/376 (30%), Positives = 174/376 (46%), Gaps = 53/376 (14%)

Query: 203 VLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQ 262
           V  E+VETE+ YV DL  IVE Y+  +   GV      +   +F NI+ IYE+  +  L+
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSE-LLE 164

Query: 263 ELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDS-----YFEELRQQL 317
           +L+        +A+ F++      +Y +YC N P S  ++ E   S     + +E + QL
Sbjct: 165 DLENS-SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQL 223

Query: 318 GHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTAD---LEQAVEVMCFVPKRCND 374
            H L L   L+KPVQRI+KY LLL++  K++   G  T     +E+A+  M  V    ND
Sbjct: 224 RHSLPLQSFLLKPVQRILKYHLLLQELGKHW-AEGPGTGGREMVEEAIVSMTAVAWYIND 282

Query: 375 MM-----------TLGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFL 422
           M               RL G+ G +L+A G+L+ +  F       GG    RG ER +FL
Sbjct: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF---RGGGGGGPRLRGGERLLFL 339

Query: 423 FEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRG-PEGGIQ 481
           F ++++ ++      R G +  Y YK  I    L +  + + DP  F ++    P+    
Sbjct: 340 FSRMLLVAK------RRGLE--YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPK---H 387

Query: 482 RYVLQAADPAISQAWI---------KHVAQILESQRDFL--NALQ-SPIEYQRRESQTNS 529
           R++LQA +    + WI          H A I    +  L  N+L  +P      E  T  
Sbjct: 388 RHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPP 447

Query: 530 LG--RPRGPGVGSPGR 543
           LG  RPR     +PGR
Sbjct: 448 LGSPRPRDARSFTPGR 463



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 12/110 (10%)

Query: 7    PAPGRTDRILGVMGGMLRA--CALPGQEGPPRRSPLGLVGTEPESERTEGDHRRDREHEV 64
            P P +T  +L   GG L +    L   +  P  SP       P S +  G +       +
Sbjct: 1228 PTPVQTTMVLSKPGGSLASHVARLESSDLTPPHSP------PPSSRQLLGPNAAALSRYL 1281

Query: 65   LAGALQPESYSIAGSEG-SISASAASGLAAPSGPSSGLSSGPCSPGPPGP 113
             A  +   S S+A  +G    A AAS  +  S P+S  SS P  P PP P
Sbjct: 1282 AASYI---SQSLARRQGPGGGAPAASRGSWSSAPTSRASSPPPQPQPPPP 1328


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 99/402 (24%), Positives = 174/402 (43%), Gaps = 51/402 (12%)

Query: 65  LAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLD 122
           +A    P++   + S G + A      A    P S  ++G  SP  GP G +SG  +  +
Sbjct: 14  IAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPN 73

Query: 123 HSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEE 179
                 S      S  AG  EN+  E  L  G   P  T+L    E   D   P   P+E
Sbjct: 74  RDSGIDS----PSSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQE 124

Query: 180 ET---LSQAPESEEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYM 226
           E    + + P+SE   +K             ++ +++  EL+ TE+ YV  L  + + + 
Sbjct: 125 EADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184

Query: 227 ATMAAQGVP-ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIK 280
             +   G+P E + G    +F NI  I+ +H  + L EL+  + + +W     L  +  K
Sbjct: 185 TRLTDAGIPPEVIMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQK 239

Query: 281 HERRLHMYVVYCQNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQR 333
               L MY  Y +N  ++  +VS        F D      +Q++   L L   +++PVQR
Sbjct: 240 LAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQR 299

Query: 334 IMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLT 389
           + +Y+LLLKD+LK   +   D  D E+++E++       N     +  + +L     +L 
Sbjct: 300 VPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLG 359

Query: 390 AQGKLLGQDTFWVTEPEAGGLLSSRG--RERRVFLFEQIIIF 429
            +  ++      + E +   L +  G  ++R +FLF  +I++
Sbjct: 360 GEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 99/402 (24%), Positives = 174/402 (43%), Gaps = 51/402 (12%)

Query: 65  LAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLD 122
           +A    P++   + S G + A      A    P S  ++G  SP  GP G +SG  +  +
Sbjct: 14  IAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPN 73

Query: 123 HSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEE 179
                 S      S  AG  EN+  E  L  G   P  T+L    E   D   P   P+E
Sbjct: 74  RDSGIDS----PSSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQE 124

Query: 180 ET---LSQAPESEEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYM 226
           E    + + P+SE   +K             ++ +++  EL+ TE+ YV  L  + + + 
Sbjct: 125 EADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184

Query: 227 ATMAAQGVP-ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIK 280
             +   G+P E + G    +F NI  I+ +H  + L EL+  + + +W     L  +  K
Sbjct: 185 TRLTDAGIPPEVIMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQK 239

Query: 281 HERRLHMYVVYCQNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQR 333
               L MY  Y +N  ++  +VS        F D      +Q++   L L   +++PVQR
Sbjct: 240 LAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQR 299

Query: 334 IMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLT 389
           + +Y+LLLKD+LK   +   D  D E+++E++       N     +  + +L     +L 
Sbjct: 300 VPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLG 359

Query: 390 AQGKLLGQDTFWVTEPEAGGLLSSRG--RERRVFLFEQIIIF 429
            +  ++      + E +   L +  G  ++R +FLF  +I++
Sbjct: 360 GEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 75/267 (28%), Positives = 126/267 (47%), Gaps = 29/267 (10%)

Query: 180 ETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLR 239
           E +S  P+  E  K+         L E+ +TE+ Y D LG I + ++  +     P+ + 
Sbjct: 181 EPVSMPPKMTEYDKRCCC------LREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIE 234

Query: 240 GRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW--LAQLFIKHERRLHMYVVYC-QNKP 296
               I+F NI+ +   H  +FL+E++  L  P    L Q+FIK++ R  +Y  YC Q + 
Sbjct: 235 ----IIFINIEDLLRVHT-HFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVES 289

Query: 297 KSEHV-----VSEFGDSYFEELRQQLGH-RLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
            S+H+       E      EE  Q+  + R  L DLL+ P+QR++KY LLL++ +K+   
Sbjct: 290 ASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQE 349

Query: 351 AGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPE 406
           A M+  +L  A++ M  + +  N    D  TL ++  F+  +    + L Q       P+
Sbjct: 350 A-MEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSI----ENLDQSLAHYGRPK 404

Query: 407 AGGLLSSRGRERRVFLFEQIIIFSEAL 433
             G L     ERR  +     +  +AL
Sbjct: 405 IDGELKITSVERRSKMDRYAFLLDKAL 431


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 98/409 (23%), Positives = 170/409 (41%), Gaps = 55/409 (13%)

Query: 170 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 229
           P D   P    + ++   +E +  K  +  +  V++E++ TE+ Y+  L  I EGY+   
Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314

Query: 230 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 286
             +    S   + R +FGNI+ IY   + +     QR  ++   L++L   F++H+    
Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373

Query: 287 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 340
           +Y  YC N P +   +S          +FE  R  Q    + L+  L+ PVQ+I KY L 
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433

Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 387
           L + LKY +    D  D+E A+  M  V +  N+                 +  +EG+  
Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493

Query: 388 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 444
           L    +L+   +   VT+P+A      + ++R  FLF+  +I+   + L   V       
Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540

Query: 445 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 497
             YK  + +  L       G + +L           RG  G    ++L    P   Q W+
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598

Query: 498 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPGVGSP 541
           K  A+  E  +       S  E QR+++  N+      G+P+G    +P
Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAP 647


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 61/214 (28%), Positives = 108/214 (50%), Gaps = 31/214 (14%)

Query: 181 TLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM-----AAQGVP 235
           TLS +   E E+K         ++ EL+ETE+ YV  L  + + +   +     +++  P
Sbjct: 93  TLSGSGTQEPEKK---------IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFP 143

Query: 236 ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFI-----KHERRLHMYVV 290
           E +    R++F NI  IY++H  +FL ELQR L D  W A   I     K    L MY  
Sbjct: 144 EDVV---RVIFSNISSIYQFHSQFFLPELQRRLDD--WTANPRIGDVIQKLAPFLKMYSE 198

Query: 291 YCQNKPKSEHVVSEFGDS--YFEELRQQL-----GHRLQLNDLLIKPVQRIMKYQLLLKD 343
           Y +N  ++  +++ + D    F+E+  ++        L L   +++PVQRI +Y+LLLK+
Sbjct: 199 YVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKE 258

Query: 344 FLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMT 377
           +++       D AD ++A++++    +  N  +T
Sbjct: 259 YIQKLPAQAPDQADAQKALDMIFSAAQHSNAAIT 292


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 97/405 (23%), Positives = 168/405 (41%), Gaps = 55/405 (13%)

Query: 170 PGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATM 229
           P D   P    + ++   +E +  K  +  +  V++E++ TE+ Y+  L  I EGY+   
Sbjct: 257 PADDDAPLAGNSGAEDGGAEAQSSKDQMRTN--VINEILSTERDYIKHLRDICEGYVRQC 314

Query: 230 AAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQL---FIKHERRLH 286
             +    S   + R +FGNI+ IY   + +     QR  ++   L++L   F++H+    
Sbjct: 315 RKRADMFS-EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373

Query: 287 MYVVYCQNKPKSEHVVSEFGDS-----YFEELRQ-QLGHRLQLNDLLIKPVQRIMKYQLL 340
           +Y  YC N P +   +S          +FE  R  Q    + L+  L+ PVQ+I KY L 
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQ 433

Query: 341 LKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMTLGRLRGFEGK-- 387
           L + LKY +    D  D+E A+  M  V +  N+                 +  +EG+  
Sbjct: 434 LAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDL 493

Query: 388 LTAQGKLL-GQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIF--SEALGGGVRGGTQPG 444
           L    +L+   +   VT+P+A      + ++R  FLF+  +I+   + L   V       
Sbjct: 494 LVRSSELIYSGELTRVTQPQA------KSQQRMFFLFDHQLIYCKKDLLRRDV------- 540

Query: 445 YVYKNSIKVSCL-------GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWI 497
             YK  + +  L       G + +L           RG  G    ++L    P   Q W+
Sbjct: 541 LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATG--DSHLLCTRKPEQKQRWL 598

Query: 498 KHVAQILESQRDFLNALQSPIEYQRRESQTNS-----LGRPRGPG 537
           K  A+  E  +       S  E QR+++  N+      G+P+  G
Sbjct: 599 KAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVG 643


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 91/411 (22%), Positives = 163/411 (39%), Gaps = 76/411 (18%)

Query: 84  SASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYE 143
           S S   GL  P+ PSS  +    SP    P SGL  + D S      +       A    
Sbjct: 387 SISFPEGLRTPASPSSANAFYSLSPSTLVP-SGLPEFKDSSSSLTDPQVSYVKSPAAERR 445

Query: 144 NWMLEPALATGEELPELTLL--TTLLEGPGDKTQPPEEETLS-----------QAPESEE 190
           +     A+A G + P    L    L  GPG  T+ P+    S           Q P    
Sbjct: 446 SG----AVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSPAFQVPLGPA 501

Query: 191 EQ-------------------------KKKALERSMYVLSELVETEKMYVDDLGQIVEGY 225
           EQ                         K+   + + +++ E++ TE+ Y+ DL  I   +
Sbjct: 502 EQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWF 561

Query: 226 MATMAAQ-GVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLK------------DPD 272
            + +  +  +P +L     ++F NI  IYE+HR  FL+E+++ L                
Sbjct: 562 RSAVVKEDAMPATLM---TLLFSNIDPIYEFHRG-FLREVEQRLALWEGPSKAHTKGSHQ 617

Query: 273 WLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFG---------DSYFEELRQQLGHRLQL 323
            +  + +++ R+L  +  Y Q   + + V++E           ++ ++E   Q    L L
Sbjct: 618 RIGDILLRNMRQLKEFTSYFQ---RHDEVLTELEKATKRCKKLEAVYKEFELQKVCYLPL 674

Query: 324 NDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMM----TLG 379
           N  L+KP+QR++ Y+LLL+    +Y+    D AD   A++ +  V      ++     L 
Sbjct: 675 NTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQ 734

Query: 380 RLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFS 430
           +L   +  L     L+     ++ E     L     ++R  FLF  +++++
Sbjct: 735 KLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYT 785


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 55/221 (24%), Positives = 108/221 (48%), Gaps = 14/221 (6%)

Query: 167 LEGPGDKTQPPEEETLSQAP--ESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEG 224
           LE   D+ +  E++     P  E +E  +    ++  ++ +EL++TEK YV  L  + + 
Sbjct: 339 LEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQV 398

Query: 225 YMATMAAQGVPESLRGRDRI--VFGNIQQIYEWHRDYFLQELQRCLKDPDW---LAQLFI 279
           + A +  +    S    D +  +F NI  IY +H+ + L EL++ +++ D    +  +  
Sbjct: 399 FCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQ 458

Query: 280 KHERRLHMYVVYCQNKPKSEHVVS-------EFGDSYFEELRQQLGHRLQLNDLLIKPVQ 332
           K    L MY  Y +N  ++  +V+       +F     E  +++    L L   +++PVQ
Sbjct: 459 KLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQ 518

Query: 333 RIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN 373
           RI +Y+LLLKD+L        D+ D ++++E++    +  N
Sbjct: 519 RIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSN 559


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.136    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,890,030
Number of Sequences: 37866
Number of extensions: 1580027
Number of successful extensions: 9155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 8025
Number of HSP's gapped (non-prelim): 1267
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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