Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157743288
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3
[Homo sapiens]
(467 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom... 946 0.0
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom... 556 e-158
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec... 545 e-155
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 314 1e-85
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 314 1e-85
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 306 2e-83
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 305 4e-83
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 299 3e-81
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 296 4e-80
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 292 5e-79
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 266 2e-71
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 262 6e-70
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 261 7e-70
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 261 7e-70
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 260 2e-69
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 259 4e-69
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 259 5e-69
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur... 257 2e-68
gi|4504023 glycine receptor, beta [Homo sapiens] 245 5e-65
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] 245 7e-65
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 239 5e-63
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 236 3e-62
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 236 4e-62
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 232 5e-61
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 231 1e-60
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 230 2e-60
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 223 2e-58
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 223 2e-58
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 223 2e-58
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 221 8e-58
>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
sapiens]
Length = 467
Score = 946 bits (2444), Expect = 0.0
Identities = 467/467 (100%), Positives = 467/467 (100%)
Query: 1 MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQK 60
MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQK
Sbjct: 1 MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQK 60
Query: 61 YEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLS 120
YEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLS
Sbjct: 61 YEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLS 120
Query: 121 FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITV 180
FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITV
Sbjct: 121 FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITV 180
Query: 181 SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFS 240
SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFS
Sbjct: 181 SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFS 240
Query: 241 ASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARV 300
ASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARV
Sbjct: 241 ASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARV 300
Query: 301 SLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEER 360
SLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEER
Sbjct: 301 SLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEER 360
Query: 361 KQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS 420
KQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS
Sbjct: 361 KQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS 420
Query: 421 RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV
Sbjct: 421 RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
sapiens]
Length = 479
Score = 556 bits (1433), Expect = e-158
Identities = 275/418 (65%), Positives = 325/418 (77%), Gaps = 2/418 (0%)
Query: 49 KKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTF 108
+ D TK+ K EQLL I+D+DF+MRPGFGG +PVG+DV VES+DSISE +MDFTMT
Sbjct: 63 RSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTL 122
Query: 109 YLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHP 168
YLRHYWKDERLSFPST N SMTFD RL +KIWVPD+FFVHSKRSFIHDTT +N+MLRV P
Sbjct: 123 YLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQP 182
Query: 169 DGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEH 228
DG VL SLR+TV+AMC MDFSRFPLDTQ CSLE+ESYAY EDDLMLYWK GN SL T+E
Sbjct: 183 DGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDER 242
Query: 229 MSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVS 288
+SLSQF I++F ++ LAFYSSTGWYNRL+INF LRRH+FFF+LQTYFPA LMVMLSWVS
Sbjct: 243 ISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVS 302
Query: 289 FWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEY 348
FWIDRRAVPARV LGITTVLTMSTIIT V+ASMP+VSY+KAVD+YLWVS +FVFLSV+EY
Sbjct: 303 FWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEY 362
Query: 349 AAVNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMR 408
AAVNYLTTV+ERK+ K K+ + + DG Y D E++ + N E R
Sbjct: 363 AAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDR 422
Query: 409 RKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
+ +++ S +R+ +V I + H ID YSRI+FP YILFNL YW ++
Sbjct: 423 MMVQLTLASERSSPQRKSQRSSYVSMRI--DTHAIDKYSRIIFPAAYILFNLIYWSIF 478
>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
precursor [Homo sapiens]
Length = 490
Score = 545 bits (1404), Expect = e-155
Identities = 275/461 (59%), Positives = 342/461 (74%), Gaps = 4/461 (0%)
Query: 10 FTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIED 69
FT + + L + + K +R + ++ K D TK R K +QLL +++
Sbjct: 29 FTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDE 88
Query: 70 NDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSM 129
+DF+MRP FGG +PVG+DV VES+DSISE +MDFTMT YLRHYWKDERL+F S +NKSM
Sbjct: 89 HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSM 148
Query: 130 TFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFS 189
TFD RL +KIWVPD+FFVHSKRSF HDTT +NIMLRV PDG+VL S+RITV+AMC MDFS
Sbjct: 149 TFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFS 208
Query: 190 RFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYS 249
FPLD+Q CSLELESYAY ++DLMLYWK+G++SL T+E +SLSQF I+ F +S LAFYS
Sbjct: 209 HFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYS 268
Query: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309
STGWYNRL+INF LRRH+FFF+LQTYFPA LMVMLSWVSFWIDRRAVPARVSLGITTVLT
Sbjct: 269 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLT 328
Query: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKI 369
M+TIIT V+ASMP+VSY+KAVD+YLWVS +FVFLSV+EYAAVNYLTTV+ERK+ K K
Sbjct: 329 MTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKF 388
Query: 370 SRMYNIDAVQAMAFDGCYHDSEID--MDQTSLSLNSEDFMRRKSI--CSPSTDSSRIKRR 425
M + + M DG Y +SE + + +E+ + K + S +++ +++
Sbjct: 389 PCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKK 448
Query: 426 KSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
L G G I +N H ID YSR++FP YI FNL YW V+
Sbjct: 449 GLLKGQTGFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVF 489
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 314 bits (804), Expect = 1e-85
Identities = 173/428 (40%), Positives = 259/428 (60%), Gaps = 35/428 (8%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP FGG PV VG+++ + SID +SE NMD+T+T Y + YW+D+RL++ S ++T
Sbjct: 49 DIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNLT 107
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R
Sbjct: 108 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 167
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYS 249
+PLD QNC+LE+ESY Y DD+ YW+ G+K++ E + L QF +E S + F
Sbjct: 168 YPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF-- 225
Query: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309
+TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+ A ARV+LGITTVLT
Sbjct: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285
Query: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL----TTVEERKQFKK 365
M+TI T + ++P++ Y+KA+D+YL +FVFL+++EYA VNY+ ++K +K
Sbjct: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345
Query: 366 TGKI------SRMYNIDAVQAMAFDGCYHDSEI--------DMDQTSLSLNSEDFMRRKS 411
T K S +DA + +E+ D +++S ++ RK
Sbjct: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405
Query: 412 ICSPSTDSSRI------------KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFN 459
P R RR+S + L + + ID +SRI+FP + LFN
Sbjct: 406 -SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFN 464
Query: 460 LFYWGVYV 467
L YW YV
Sbjct: 465 LVYWLYYV 472
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 314 bits (804), Expect = 1e-85
Identities = 173/428 (40%), Positives = 259/428 (60%), Gaps = 35/428 (8%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP FGG PV VG+++ + SID +SE NMD+T+T Y + YW+D+RL++ S ++T
Sbjct: 49 DIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNLT 107
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R
Sbjct: 108 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 167
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYS 249
+PLD QNC+LE+ESY Y DD+ YW+ G+K++ E + L QF +E S + F
Sbjct: 168 YPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF-- 225
Query: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309
+TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+ A ARV+LGITTVLT
Sbjct: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285
Query: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL----TTVEERKQFKK 365
M+TI T + ++P++ Y+KA+D+YL +FVFL+++EYA VNY+ ++K +K
Sbjct: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345
Query: 366 TGKI------SRMYNIDAVQAMAFDGCYHDSEI--------DMDQTSLSLNSEDFMRRKS 411
T K S +DA + +E+ D +++S ++ RK
Sbjct: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405
Query: 412 ICSPSTDSSRI------------KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFN 459
P R RR+S + L + + ID +SRI+FP + LFN
Sbjct: 406 -SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFN 464
Query: 460 LFYWGVYV 467
L YW YV
Sbjct: 465 LVYWLYYV 472
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 306 bits (785), Expect = 2e-83
Identities = 172/428 (40%), Positives = 251/428 (58%), Gaps = 34/428 (7%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP FGG PV VG+ + V SID +SE NMD+T+T Y + WKD+RLS+ S ++T
Sbjct: 49 DIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSY-SGIPLNLT 107
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R
Sbjct: 108 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 167
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
+PLD QNC+LE+ESY Y DD+ YW G ++ + L QF I D+ S + +
Sbjct: 168 YPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEF-T 226
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG Y RL ++F L+R++ +F+LQTY P+ L+ +LSWVSFWI+ A ARV+LGITTVLTM
Sbjct: 227 TGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTM 286
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL----------TTVEER 360
+TI T + ++P++ Y+KA+D+YL +FVFL+++EYA VNY+ + +++
Sbjct: 287 TTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQ 346
Query: 361 KQFKKTGKISRMYNIDA-----VQAMAFDGCYHDSEI-----DMDQTSLSLNSEDFMRRK 410
+K +DA + + SE+ D T S +S RK
Sbjct: 347 SANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRK 406
Query: 411 SICSPST-----------DSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFN 459
+ S RI+RR S V L + + ID +SR+ FPI + LFN
Sbjct: 407 PLSSREAYGRALDRHGVPSKGRIRRRAS-QLKVKIPDLTDVNSIDKWSRMFFPITFSLFN 465
Query: 460 LFYWGVYV 467
+ YW YV
Sbjct: 466 VVYWLYYV 473
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 305 bits (782), Expect = 4e-83
Identities = 169/431 (39%), Positives = 259/431 (60%), Gaps = 39/431 (9%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP FGG PV VG+++ + SID +SE NMD+T+T Y + W+D+RLS+ + ++T
Sbjct: 48 DIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSY-NVIPLNLT 106
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R
Sbjct: 107 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 166
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
+PLD QNC+LE+ESY Y DD+ YW+ + ++ + L QF I D+ + + S
Sbjct: 167 YPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVF-S 225
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+ A ARV+LGITTVLTM
Sbjct: 226 TGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTM 285
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKIS 370
+TI T + ++P++ Y+KA+D+YL +FVF++++EYA VNY+ ++ KK + +
Sbjct: 286 TTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKA 345
Query: 371 RMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRR--KSICSPST-----DSSRIK 423
N + M D D ++ ++L + +E + P + D+S I+
Sbjct: 346 ASAN---NEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQ 402
Query: 424 RRKS-LGGH-VGRIILENN-------------------------HVIDTYSRILFPIVYI 456
RK+ L H GR LE + + ID +SRI FP+V+
Sbjct: 403 YRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFS 462
Query: 457 LFNLFYWGVYV 467
FN+ YW YV
Sbjct: 463 FFNIVYWLYYV 473
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 299 bits (766), Expect = 3e-81
Identities = 151/398 (37%), Positives = 240/398 (60%), Gaps = 9/398 (2%)
Query: 75 RPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHR 134
RPG GG PV V + + V SID ISE NM++TMT +L W+D RLS+ T N+++ D R
Sbjct: 56 RPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHT-NETLGLDSR 114
Query: 135 LTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLD 194
K+W+PD F V++K ++ HD T+EN ++R+ PDG +L S+RIT + C MD +++P+D
Sbjct: 115 FVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMD 174
Query: 195 TQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWY 254
Q C L+LESY Y+ +D++ YW + ++ + + L+QF I + ++ L + S G +
Sbjct: 175 EQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQF 234
Query: 255 NRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTII 314
RL ++F LRR+ +++Q+Y P++L+V +SWVSFWI + AVPARVSLGITTVLTM+T++
Sbjct: 235 PRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLM 294
Query: 315 TAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISR--- 371
+ +S+P+ S +KA+DVY W+ +FVF +++EYA ++ + RK+ K K+SR
Sbjct: 295 VSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF--NADYRKKQKAKVKVSRPRA 352
Query: 372 ---MYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSL 428
+ N + +++ G + I Q + N R + + T R
Sbjct: 353 EMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQ 412
Query: 429 GGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
GG R+ + ID Y+R +FP + N+ YW Y
Sbjct: 413 GGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
Length = 440
Score = 296 bits (757), Expect = 4e-80
Identities = 150/395 (37%), Positives = 237/395 (60%), Gaps = 9/395 (2%)
Query: 74 MRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDH 133
+RP FGG PV + + + + SI SISE+NMD+T T YLR W D+RL F NKS T D
Sbjct: 52 LRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--NKSFTLDA 109
Query: 134 RLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPL 193
RL +WVPD + V SK+SF+H+ T+ N ++R+ +G VL +LRIT + C MD S++P+
Sbjct: 110 RLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPM 169
Query: 194 DTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGW 253
DTQ C L+LES+ Y+ +D+ W GN S+ EH+ L+Q+ IE + + TG
Sbjct: 170 DTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRS-QQETGN 228
Query: 254 YNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTI 313
Y RL + F LRR+V +F+L+TY P+ +V+LSWVSFWI +VPAR +G+TTVL+M+T+
Sbjct: 229 YTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTL 288
Query: 314 ITAVSASMPQVS-YLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRM 372
+ S+P + ++KA+DVYL + FVF +++EYA +Y + ++ K G +
Sbjct: 289 MIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSL--QQMAAKDRGTTKEV 346
Query: 373 YNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHV 432
+ + +I +S ++ D+ + ++D + R+ +G V
Sbjct: 347 EEVSITNIINSSISSFKRKISFASIEISSDNVDY---SDLTMKTSDKFKFVFREKMGRIV 403
Query: 433 GRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
++N +D YS++LFP++++L N+FYW Y+
Sbjct: 404 DYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYM 438
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 292 bits (747), Expect = 5e-79
Identities = 135/284 (47%), Positives = 203/284 (71%), Gaps = 2/284 (0%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP FGG PV VG+++ + SID +SE NMD+T+T Y + W+D+RLS+ + ++T
Sbjct: 48 DIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSY-NVIPLNLT 106
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R
Sbjct: 107 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 166
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
+PLD QNC+LE+ESY Y DD+ YW+ + ++ + L QF I D+ + + S
Sbjct: 167 YPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVF-S 225
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+ A ARV+LGITTVLTM
Sbjct: 226 TGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTM 285
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL 354
+TI T + ++P++ Y+KA+D+YL +FVF++++EYA VNY+
Sbjct: 286 TTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329
Score = 37.0 bits (84), Expect = 0.038
Identities = 15/31 (48%), Positives = 21/31 (67%)
Query: 437 LENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
L + + ID +SRI FP+V+ FN+ YW YV
Sbjct: 481 LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYV 511
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 266 bits (681), Expect = 2e-71
Identities = 137/402 (34%), Positives = 235/402 (58%), Gaps = 14/402 (3%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP F G PV V ++ + S SI+ET MD+ + +LR W D RL++ + S+
Sbjct: 58 DARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLD 117
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D + IW PD+FF + K + H+ T +N +LR+ +GNVL S+R+T++ C MD
Sbjct: 118 LDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKN 177
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
FP+D Q C ++LES+ Y +DL+ W+ + E ++L QF +++ + +
Sbjct: 178 FPMDVQTCIMQLESFGYTMNDLIFEWQ-DEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYN 236
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG + + + F L R + ++++Q Y P++L+V+LSWVSFWI+ A PARV+LGITTVLTM
Sbjct: 237 TGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTM 296
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTV-EERKQFKKTGKI 369
+T + AS+P+VSY+KA+D+++ V LFVF +++EYAAVN+++ +E +F++ K
Sbjct: 297 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRK- 355
Query: 370 SRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDF-----MRRKSICSPSTDSSRIKR 424
+ +A A + Y S++D + + + ++ K +P + ++
Sbjct: 356 ------NKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQV 409
Query: 425 RKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
+ ++ ++ IDT SR FP+ +++FN+FYW +Y
Sbjct: 410 MPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 262 bits (669), Expect = 6e-70
Identities = 147/434 (33%), Positives = 241/434 (55%), Gaps = 28/434 (6%)
Query: 42 CKQ-ETRMKKDDSTKARPQKYEQLL--HIEDNDFAMRPGFGGSPVPVGIDVHVESIDSIS 98
CK ++R K S P + L D +RP F G PV V ++ + S SI+
Sbjct: 27 CKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIA 86
Query: 99 ETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTT 158
ET MD+ + +LR W D RL++ + S+ D + IW PD+FF + K + HD T
Sbjct: 87 ETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVT 146
Query: 159 MENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKH 218
+N +LR+ +G VL S+R+T++ C MD FP+D Q C+++LES+ Y +DL+ W
Sbjct: 147 TDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWL- 205
Query: 219 GNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPA 278
+ + E ++L QF +++ + +TG + + + F L R + ++++Q Y P+
Sbjct: 206 SDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 279 ILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSS 338
+L+V+LSWVSFWI+ A PARV+LGITTVLTM+T + AS+P+VSY+KA+D+++ V
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 339 LFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYN--IDAVQAMAFD----GCYHDSEI 392
LFVF +++EYAAVN+++ + K+F + + + N D + F+ G H ++
Sbjct: 326 LFVFAALLEYAAVNFVS--RQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQV 383
Query: 393 DMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFP 452
D T++ + + P D IK++ ++ IDT SR FP
Sbjct: 384 -KDGTAVKATPAN-----PLPQPPKDGDAIKKK----------FVDRAKRIDTISRAAFP 427
Query: 453 IVYILFNLFYWGVY 466
+ +++FN+FYW Y
Sbjct: 428 LAFLIFNIFYWITY 441
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 261 bits (668), Expect = 7e-70
Identities = 146/434 (33%), Positives = 241/434 (55%), Gaps = 28/434 (6%)
Query: 42 CKQ-ETRMKKDDSTKARPQKYEQLL--HIEDNDFAMRPGFGGSPVPVGIDVHVESIDSIS 98
CK ++R K S P + L D +RP F G PV V ++ + S S++
Sbjct: 27 CKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVT 86
Query: 99 ETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTT 158
ET MD+ + +LR W D RL++ + S+ D + IW PD+FF + K + HD T
Sbjct: 87 ETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVT 146
Query: 159 MENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKH 218
+N +LR+ +G VL S+R+T++ C MD FP+D Q C+++LES+ Y +DL+ W
Sbjct: 147 TDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWL- 205
Query: 219 GNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPA 278
+ + E ++L QF +++ + +TG + + + F L R + ++++Q Y P+
Sbjct: 206 SDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 279 ILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSS 338
+L+V+LSWVSFWI+ A PARV+LGITTVLTM+T + AS+P+VSY+KA+D+++ V
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 339 LFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYN--IDAVQAMAFD----GCYHDSEI 392
LFVF +++EYAAVN+++ + K+F + + + N D + F+ G H ++
Sbjct: 326 LFVFAALLEYAAVNFVS--RQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQV 383
Query: 393 DMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFP 452
D T++ + + P D IK++ ++ IDT SR FP
Sbjct: 384 -KDGTAVKATPAN-----PLPQPPKDGDAIKKK----------FVDRAKRIDTISRAAFP 427
Query: 453 IVYILFNLFYWGVY 466
+ +++FN+FYW Y
Sbjct: 428 LAFLIFNIFYWITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 261 bits (668), Expect = 7e-70
Identities = 146/434 (33%), Positives = 241/434 (55%), Gaps = 28/434 (6%)
Query: 42 CKQ-ETRMKKDDSTKARPQKYEQLL--HIEDNDFAMRPGFGGSPVPVGIDVHVESIDSIS 98
CK ++R K S P + L D +RP F G PV V ++ + S S++
Sbjct: 27 CKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVT 86
Query: 99 ETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTT 158
ET MD+ + +LR W D RL++ + S+ D + IW PD+FF + K + HD T
Sbjct: 87 ETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVT 146
Query: 159 MENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKH 218
+N +LR+ +G VL S+R+T++ C MD FP+D Q C+++LES+ Y +DL+ W
Sbjct: 147 TDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWL- 205
Query: 219 GNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPA 278
+ + E ++L QF +++ + +TG + + + F L R + ++++Q Y P+
Sbjct: 206 SDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 279 ILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSS 338
+L+V+LSWVSFWI+ A PARV+LGITTVLTM+T + AS+P+VSY+KA+D+++ V
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 339 LFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYN--IDAVQAMAFD----GCYHDSEI 392
LFVF +++EYAAVN+++ + K+F + + + N D + F+ G H ++
Sbjct: 326 LFVFAALLEYAAVNFVS--RQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQV 383
Query: 393 DMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFP 452
D T++ + + P D IK++ ++ IDT SR FP
Sbjct: 384 -KDGTAVKATPAN-----PLPQPPKDGDAIKKK----------FVDRAKRIDTISRAAFP 427
Query: 453 IVYILFNLFYWGVY 466
+ +++FN+FYW Y
Sbjct: 428 LAFLIFNIFYWITY 441
>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 449
Score = 260 bits (664), Expect = 2e-69
Identities = 139/396 (35%), Positives = 233/396 (58%), Gaps = 10/396 (2%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP F G PV V ++ + S SI+ET MD+ + +LR W D RL++ + S+
Sbjct: 53 DARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLD 112
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D + IW PD+FF + K + H+ T +N +LR+ +GNVL S+RIT++ C MD
Sbjct: 113 LDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKN 172
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
FP+D Q C ++LES+ Y +DL+ W+ ++ + ++L QF +++ + +
Sbjct: 173 FPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVADGLTLPQFILKEEKDLRYCTKHYN 231
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG + + F L R + ++++Q Y P++L+V+LSW+SFWI+ A PARV LGITTVLTM
Sbjct: 232 TGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTM 291
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKIS 370
+T + AS+P+VSY+KA+D+++ V LFVF +++EYAAVN+++ + K+ + +
Sbjct: 292 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVS--RQHKELLRFRRKR 349
Query: 371 RMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGG 430
R + D A +G ++ S M L ++D + K + +T + KS
Sbjct: 350 RHHKEDE----AGEGRFNFSAYGMGPA--CLQAKDGISVKGANNSNTTNPPPAPSKS-PE 402
Query: 431 HVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
+ ++ ++ ID SRI FP+ +++FN+FYW +Y
Sbjct: 403 EMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 438
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 259 bits (662), Expect = 4e-69
Identities = 141/399 (35%), Positives = 235/399 (58%), Gaps = 8/399 (2%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP F G PV V ++ + S SI+ET MD+ + +LR W D RL++ + S+
Sbjct: 53 DARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLD 112
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D + IW PD+FF + K + H+ T +N +LR+ +GNVL S+RIT++ C MD
Sbjct: 113 LDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKN 172
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
FP+D Q C ++LES+ Y +DL+ W+ ++ + ++L QF +++ + +
Sbjct: 173 FPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVADGLTLPQFILKEEKDLRYCTKHYN 231
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG + + F L R + ++++Q Y P++L+V+LSW+SFWI+ A PARV LGITTVLTM
Sbjct: 232 TGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTM 291
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEE---RKQFKKTG 367
+T + AS+P+VSY+KA+D+++ V LFVF +++EYAAVN+++ + R + K+
Sbjct: 292 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRH 351
Query: 368 KISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKS 427
S M N+ + A +G ++ S M L ++D + K + +T + KS
Sbjct: 352 HKSPMLNL-FQEDEAGEGRFNFSAYGMGPA--CLQAKDGISVKGANNSNTTNPPPAPSKS 408
Query: 428 LGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
+ ++ ++ ID SRI FP+ +++FN+FYW +Y
Sbjct: 409 -PEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 259 bits (661), Expect = 5e-69
Identities = 135/397 (34%), Positives = 228/397 (57%), Gaps = 19/397 (4%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP F G PV V ++ + S SI+ET MD+ + +LR W D RL++ + S+
Sbjct: 58 DARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLD 117
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D + IW PD+FF + K + H+ T +N +LR+ +GNVL S+R+T++ C MD
Sbjct: 118 LDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKN 177
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
FP+D Q C ++LES+ Y +DL+ W+ + E ++L QF +++ + +
Sbjct: 178 FPMDVQTCIMQLESFGYTMNDLIFEWQ-DEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYN 236
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG + + + F L R + ++++Q Y P++L+V+LSWVSFWI+ A PARV+LGITTVLTM
Sbjct: 237 TGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTM 296
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTV-EERKQFKKTGKI 369
+T + AS+P+VSY+KA+D+++ V LFVF +++EYAAVN+++ +E +F++
Sbjct: 297 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR---- 352
Query: 370 SRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLG 429
R D V+ F + + ++ K +P + ++
Sbjct: 353 KRKNKDDEVRESRF-------------SFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSP 399
Query: 430 GHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466
+ ++ ++ IDT SR FP+ +++FN+FYW +Y
Sbjct: 400 DEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 436
>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
[Homo sapiens]
Length = 632
Score = 257 bits (656), Expect = 2e-68
Identities = 117/285 (41%), Positives = 191/285 (67%), Gaps = 4/285 (1%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP FGG+PVPV I ++V SI+ ISE NMD+T+T + WKD RL++ T ++T
Sbjct: 71 DVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETT-LNLT 129
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D+R+ K+WVPD +F++SK +F+HD T+EN + ++HPDG V +R+T +A C +D +
Sbjct: 130 LDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHK 189
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYS 249
FP+D Q C+L +ESY Y +D++L+W +++ E + + QF F+ S + FY
Sbjct: 190 FPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFY- 248
Query: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309
TG Y RL + F ++R V +++Q Y+P +L + SW+SFW++ + ARV++G+T++L
Sbjct: 249 -TGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLI 307
Query: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL 354
++TI + + +P +S +KA+D+Y+ V FVFLS++EY +NYL
Sbjct: 308 LTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYL 352
Score = 32.3 bits (72), Expect = 0.94
Identities = 11/21 (52%), Positives = 16/21 (76%)
Query: 443 IDTYSRILFPIVYILFNLFYW 463
+D +SR LFP+ + LFN+ YW
Sbjct: 607 VDKWSRFLFPLAFGLFNIVYW 627
>gi|4504023 glycine receptor, beta [Homo sapiens]
Length = 497
Score = 245 bits (626), Expect = 5e-65
Identities = 146/433 (33%), Positives = 232/433 (53%), Gaps = 39/433 (9%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPST--ANKS 128
D +RP F G PV V +++ + S SI ET MD+ + +LR W D RL PS + +
Sbjct: 68 DPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDA 127
Query: 129 MTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDF 188
+T D + + +W PD+FF + K + HD T ENI+L + DG+VL+S+R++++ C +D
Sbjct: 128 LTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDL 187
Query: 189 SRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFI--EDFSASSGLA 246
+ FP+DTQ C ++LES+ Y DDL W+ G+ E ++L QF I ED +
Sbjct: 188 TLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPV--QLEKIALPQFDIKKEDIEYGNCTK 245
Query: 247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITT 306
+Y TG+Y + + F LRR V F+++ Y P +L+V+LSW+SFWI+ A ARV LGI +
Sbjct: 246 YYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFS 305
Query: 307 VLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKT 366
VL++++ T ++A +P+VSY+KA+DV+L LF F S++EYA V + +R + +K
Sbjct: 306 VLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEK- 364
Query: 367 GKISRMYNID-----AVQAMAFDGC---YHDSEIDMDQT--------SLSLNSEDFM--- 407
+I++ D + +G H S + + +T L S DF
Sbjct: 365 ARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVG 424
Query: 408 ---RRKSICSPSTDSSRIKRRKSLGGHVGR----------IILENNHVIDTYSRILFPIV 454
R + + I+ LG + +I ID Y+R LFP
Sbjct: 425 SLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFC 484
Query: 455 YILFNLFYWGVYV 467
++ FN+ YW +Y+
Sbjct: 485 FLFFNVIYWSIYL 497
>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
Length = 417
Score = 245 bits (625), Expect = 7e-65
Identities = 120/315 (38%), Positives = 192/315 (60%), Gaps = 4/315 (1%)
Query: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
D +RP F G PV V ++ + S SI++T MD+ + +LR W D RLS+ + S+
Sbjct: 59 DARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLD 118
Query: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
D + IW PD+FF + K + H+ T +N +LR+ +GNVL S+R+T+ C MD
Sbjct: 119 LDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKN 178
Query: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
FP+D Q C+++LES+ Y DL+ W ++ E ++L QF + D + +
Sbjct: 179 FPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYN 238
Query: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
TG + + + F L R + ++++Q Y P++L+V+LSWVSFWI+ A PARV LGITTVLTM
Sbjct: 239 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTM 298
Query: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKIS 370
+T + AS+P+VSY+KA+D+++ V LFVF +++EYAA+N+++ + K+F + +
Sbjct: 299 TTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVS--RQHKEFIRLRRRQ 356
Query: 371 RMYNI--DAVQAMAF 383
R + D +Q F
Sbjct: 357 RRQRLEEDIIQESRF 371
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 239 bits (609), Expect = 5e-63
Identities = 142/405 (35%), Positives = 223/405 (55%), Gaps = 17/405 (4%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
++ D +RP G P + DV+V SI + NM++T+ W D RL F ST
Sbjct: 72 LQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTM- 130
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
K + + + KIW+PD FF +S++S H T N +LR+ DG VL +LR+T++A C++
Sbjct: 131 KVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYL 190
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLA 246
FP+D +C LE SY Y ++++ WK + + ++ L QF S+ +
Sbjct: 191 QLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEIT 250
Query: 247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITT 306
++ +G Y + I F L R + +F +QTY P IL V+LSWVSFWI++ AVPAR SLGITT
Sbjct: 251 -HTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITT 309
Query: 307 VLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKT 366
VLTM+T+ T S+P+VSY+ A+D+++ V +FVF +++EY ++Y T+ ++ K K
Sbjct: 310 VLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKD 369
Query: 367 GKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSR----I 422
K+ +A G + S + + ++S+ ED + C D +
Sbjct: 370 RKLKN-------KASMTPGLHPGSTL-IPMNNISVPQEDDYGYQ--CLEGKDCASFFCCF 419
Query: 423 KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
+ ++ GRI + ID+YSRI FP + LFNL YW Y+
Sbjct: 420 EDCRTGSWREGRIHIRIAK-IDSYSRIFFPTAFALFNLVYWVGYL 463
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 236 bits (602), Expect = 3e-62
Identities = 139/407 (34%), Positives = 219/407 (53%), Gaps = 13/407 (3%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
+E D +RP G P + D++V SI ++ NM++T+ + W D RL F ST
Sbjct: 74 LEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTI- 132
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
K + + + KIW+PD FF +SK++ H T N MLR+ DG VL +LR+T+ A C +
Sbjct: 133 KVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQL 192
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLA 246
FP+D +C LE SY Y ++++ WK + + L QF ++ +
Sbjct: 193 QLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVV 252
Query: 247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITT 306
+++G Y + + F L R + +F +QTY P L+V+LSWVSFWI++ AVPAR SLGITT
Sbjct: 253 -KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311
Query: 307 VLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKT 366
VLTM+T+ T S+P+VSY+ A+D+++ V +FVF +++EY ++Y + + + K
Sbjct: 312 VLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDK 371
Query: 367 GKISRMYNIDAVQAMAFDGCYHDSEIDMDQ-TSLSLNSEDFMRRKSICSPSTDSSRI--- 422
K + + + + +A D + I M+ T L E++ C D +
Sbjct: 372 KKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYE---CLDGKDCASFFCC 428
Query: 423 --KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
R H GRI + + D+Y+RI FP + LFNL YW Y+
Sbjct: 429 FEDCRTGAWRH-GRIHIRIAKM-DSYARIFFPTAFCLFNLVYWVSYL 473
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 236 bits (601), Expect = 4e-62
Identities = 151/417 (36%), Positives = 229/417 (54%), Gaps = 31/417 (7%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
+E D +RPGFGG+ V D++V S +S+ M++TM + R W DERL F
Sbjct: 40 LEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPT- 98
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
+ ++ ++ + KIW PD FF + K+S H+ T N + R+ +G +L ++R+T++A C M
Sbjct: 99 EILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPM 158
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNK-SLNT-EEHMSLSQFFIEDFSASSG 244
FP+D C L+ SYAY + +++ WK G S+ EE SL Q+ + + SS
Sbjct: 159 RLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSE 218
Query: 245 LAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGI 304
S+TG Y + + F L+R + +F++Q Y P I+ V+LS VSFWI++ +VPAR GI
Sbjct: 219 -TIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGI 277
Query: 305 TTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFK 364
TTVLTM+T+ + S+P+VSY A+D ++ V FVF ++IE+AAVNY T ++ +K +
Sbjct: 278 TTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKR 337
Query: 365 K-------TGKISRMYN-IDAVQAMAFDGCYHDSEIDMDQTSLSL------NSEDFMRRK 410
K T IS+ ++A + D YH + TSLSL + + R
Sbjct: 338 KAQFAAPPTVTISKATEPLEAEIVLHPDSKYH---LKKRITSLSLPIVSSSEANKVLTRA 394
Query: 411 SICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
I ST + + GG ID YSRILFP+ + FNL YW VY+
Sbjct: 395 PILQ-STPVTPPPLSPAFGG---------TSKIDQYSRILFPVAFAGFNLVYWVVYL 441
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 232 bits (592), Expect = 5e-61
Identities = 135/404 (33%), Positives = 213/404 (52%), Gaps = 15/404 (3%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
+E D +RP G P + D++V SI ++ NM++T+ + W D RL F ST
Sbjct: 74 LEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTI- 132
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
K + + + KIW+PD FF +SK++ H T N MLR+ DG VL +LR+T+ A C +
Sbjct: 133 KVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQL 192
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLA 246
FP+D +C LE SY Y ++++ WK + + L QF ++ +
Sbjct: 193 QLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVV 252
Query: 247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITT 306
+++G Y + + F L R + +F +QTY P L+V+LSWVSFWI++ AVPAR SLGITT
Sbjct: 253 -KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311
Query: 307 VLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKT 366
VLTM+T+ T S+P+VSY+ A+D+++ V +FVF +++EY ++Y + + + K
Sbjct: 312 VLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDK 371
Query: 367 GKISRMYNIDAVQAMA---FDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIK 423
K + ID A + H E D + L+ +D C +
Sbjct: 372 KKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDC--ASFFCCFEDCRTGAW 429
Query: 424 RRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
R + + + +D+Y+RI FP + LFNL YW Y+
Sbjct: 430 RHGRIHIRIAK--------MDSYARIFFPTAFCLFNLVYWVSYL 465
>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
precursor [Homo sapiens]
Length = 462
Score = 231 bits (589), Expect = 1e-60
Identities = 134/409 (32%), Positives = 217/409 (53%), Gaps = 24/409 (5%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
++ D +RPG G V D++V S +S+T M++T+ + R WKDERL F
Sbjct: 57 LDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQ 116
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
+ + ++ L KIW PD FF + K+S H+ T N +LR+ DG +L ++R+T+SA C M
Sbjct: 117 R-LPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPM 175
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKS--LNTEEHMSLSQFFIEDFSASSG 244
FP+D C L+ SYAY +++ W +G+ + E+ L+Q+ + + +
Sbjct: 176 QLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTE 235
Query: 245 LAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGI 304
+STG Y + +F L+R + +FV+QTY P I+ V+LS VSFW++R +VPAR G+
Sbjct: 236 -NISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGV 294
Query: 305 TTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTT---VEERK 361
TTVLTM+T+ + S+P+V+Y A+D ++ V FVF ++IE+A VNY T + K
Sbjct: 295 TTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGK 354
Query: 362 QFKKTGKISRMYNI---DAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTD 418
+ + KI + + + A H I +QT ++ + K +++
Sbjct: 355 KALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSE 414
Query: 419 SSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
S + S ID SRI+FP+++ FNL YW Y+
Sbjct: 415 SKKTYNSIS--------------KIDKMSRIVFPVLFGTFNLVYWATYL 449
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 230 bits (587), Expect = 2e-60
Identities = 139/417 (33%), Positives = 223/417 (53%), Gaps = 22/417 (5%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
+ + D +RP G P + +D++V SI +S NM++ + + W D RL F ST
Sbjct: 55 LREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTM- 113
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
K +T + + IW+PD F +SK + H T N +LR+ DG +L +LR+T++A C +
Sbjct: 114 KILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQL 173
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLA 246
FP+D +C L SY Y +++++ W+ + ++ L QF ++ +
Sbjct: 174 QLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIV 233
Query: 247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITT 306
+S G Y + I F L R + +F +QTY P IL V+LSWVSFWI + A PAR +LGITT
Sbjct: 234 T-TSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITT 292
Query: 307 VLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKT 366
VLTM+T+ T S+P+VSY+ A+D+++ V LFVF +++EYA +NY ++ + KKT
Sbjct: 293 VLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKT 352
Query: 367 GKISRMYNIDAV-QAMAFDGCYHDSEIDM---DQTSLSLNSEDFMRRKS-----ICSPST 417
+ + + + ++ + S +DM ++LN+ + + C
Sbjct: 353 TSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGK 412
Query: 418 DSSRI----KRRKSLGGHVGRI---ILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
D + KS GRI ILE +D+YSR+ FP ++LFNL YW Y+
Sbjct: 413 DCQSFFCCYEECKSGSWRKGRIHIDILE----LDSYSRVFFPTSFLLFNLVYWVGYL 465
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 223 bits (569), Expect = 2e-58
Identities = 134/405 (33%), Positives = 219/405 (54%), Gaps = 17/405 (4%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
++ D +RPG G S V +++V S +S+T+M++T+ + R WKDERL F N
Sbjct: 50 LDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMN 109
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
+ ++ + KIW PD FF + K+S H+ TM N +LR+ DG +L ++R+TV A C M
Sbjct: 110 -ILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPM 168
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTE---EHMSLSQFFIEDFSASS 243
FP+D +C L+ SYAY ++ W + N S + + + L+Q+ + S
Sbjct: 169 HLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTY-NASDSVQVAPDGSRLNQYDLLGQSIGK 227
Query: 244 GLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLG 303
SSTG Y + +F L+R + +FV+QTY P I+ V+LS VSFW++R +VPAR G
Sbjct: 228 E-TIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG 286
Query: 304 ITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQF 363
+TTVLTM+T+ + S+P+V+Y A+D ++ V FVF ++IE+A VNY T ++ +
Sbjct: 287 VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT----KRGW 342
Query: 364 KKTGK-ISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRI 422
GK + + M + Y + + + +L+ + + S S S +
Sbjct: 343 AWDGKSVVNDKKKEKASVMIQNNAY---AVAVANYAPNLSKDPVL---STISKSATTPEP 396
Query: 423 KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
++ + + ID SRI+FP+++ FNL YW Y+
Sbjct: 397 NKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 223 bits (569), Expect = 2e-58
Identities = 134/405 (33%), Positives = 219/405 (54%), Gaps = 17/405 (4%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
++ D +RPG G S V +++V S +S+T+M++T+ + R WKDERL F N
Sbjct: 50 LDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMN 109
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
+ ++ + KIW PD FF + K+S H+ TM N +LR+ DG +L ++R+TV A C M
Sbjct: 110 -ILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPM 168
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTE---EHMSLSQFFIEDFSASS 243
FP+D +C L+ SYAY ++ W + N S + + + L+Q+ + S
Sbjct: 169 HLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTY-NASDSVQVAPDGSRLNQYDLLGQSIGK 227
Query: 244 GLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLG 303
SSTG Y + +F L+R + +FV+QTY P I+ V+LS VSFW++R +VPAR G
Sbjct: 228 E-TIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG 286
Query: 304 ITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQF 363
+TTVLTM+T+ + S+P+V+Y A+D ++ V FVF ++IE+A VNY T ++ +
Sbjct: 287 VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT----KRGW 342
Query: 364 KKTGK-ISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRI 422
GK + + M + Y + + + +L+ + + S S S +
Sbjct: 343 AWDGKSVVNDKKKEKASVMIQNNAY---AVAVANYAPNLSKDPVL---STISKSATTPEP 396
Query: 423 KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV 467
++ + + ID SRI+FP+++ FNL YW Y+
Sbjct: 397 NKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 223 bits (569), Expect = 2e-58
Identities = 139/411 (33%), Positives = 220/411 (53%), Gaps = 16/411 (3%)
Query: 67 IEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTAN 126
++ D +RPG G + V D++V S +S+T+M++T+ + R W DERL F
Sbjct: 75 LDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPM- 133
Query: 127 KSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFM 186
K + ++ L KIW PD FF + K+S H+ T N +LR+ +G +L ++R+T+ A C M
Sbjct: 134 KILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPM 193
Query: 187 DFSRFPLDTQNCSLELESYAYNEDDLMLYWKHG-NKSLNTEEHMS-LSQFFIEDFSASSG 244
FP+D C L+ SYAY +++ W G NKS+ + S L+Q+ + +
Sbjct: 194 HLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTE 253
Query: 245 LAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGI 304
+ SSTG Y + +F L+R + +FV+QTY P I+ V+LS VSFW++R +VPAR G+
Sbjct: 254 I-IRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGV 312
Query: 305 TTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFK 364
TTVLTM+T+ + S+P+V+Y A+D ++ V FVF ++IE+A VNY T + K
Sbjct: 313 TTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGK 372
Query: 365 KTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLN---SEDFMRRKSICSPSTDSSR 421
K + M + A + ++ T+ +N +F +PS S+
Sbjct: 373 KVPEALEMKK----KTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTP 428
Query: 422 IKRRKSLGGHVGRIILEN---NHV--IDTYSRILFPIVYILFNLFYWGVYV 467
+V E N V +D SRI+FP+++ +FNL YW YV
Sbjct: 429 TIIASPKATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYV 479
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 221 bits (564), Expect = 8e-58
Identities = 141/429 (32%), Positives = 219/429 (51%), Gaps = 35/429 (8%)
Query: 52 DSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLR 111
D+T + ++LL DN +RPG G V D+ V S +S+ +M++T+ + R
Sbjct: 37 DNTTVFTRILDRLLDGYDN--RLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFR 94
Query: 112 HYWKDERLSF--PSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPD 169
WKDERL F P T + ++ + KIW PD FF + K+S H+ TM N +LR+ D
Sbjct: 95 QSWKDERLKFKGPMTV---LRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITED 151
Query: 170 GNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKH--GNKSLNTEE 227
G +L ++R+TV A C M FP+D C L+ SYAY +++ W + E+
Sbjct: 152 GTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAED 211
Query: 228 HMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWV 287
L+Q+ + + SG+ SSTG Y + +F L+R + +FV+QTY P I+ V+LS V
Sbjct: 212 GSRLNQYDLLGQTVDSGIV-QSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQV 270
Query: 288 SFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIE 347
SFW++R +VPAR G+TTVLTM+T+ + S+P+V+Y A+D ++ V FVF ++IE
Sbjct: 271 SFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIE 330
Query: 348 YAAVNYLT---------TVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTS 398
+A VNY T +V K K + + N A A ++ +
Sbjct: 331 FATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSY-----TPNLARGDPG 385
Query: 399 LSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILF 458
L+ ++ P T K+ + ID SRI FP+++ +F
Sbjct: 386 LATIAKSATIEPKEVKPETKPPEPKK-----------TFNSVSKIDRLSRIAFPLLFGIF 434
Query: 459 NLFYWGVYV 467
NL YW Y+
Sbjct: 435 NLVYWATYL 443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,747,419
Number of Sequences: 37866
Number of extensions: 631467
Number of successful extensions: 2153
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1954
Number of HSP's gapped (non-prelim): 105
length of query: 467
length of database: 18,247,518
effective HSP length: 106
effective length of query: 361
effective length of database: 14,233,722
effective search space: 5138373642
effective search space used: 5138373642
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.