Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157738641
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
(540 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 1040 0.0
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 1040 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 218 9e-57
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 131 1e-30
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 118 1e-26
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 109 6e-24
gi|110349719 titin isoform N2-A [Homo sapiens] 108 9e-24
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 105 1e-22
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 102 9e-22
gi|104526627 triadin [Homo sapiens] 102 1e-21
gi|125656165 THO complex 2 [Homo sapiens] 100 3e-21
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 100 4e-21
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 98 2e-20
gi|14249342 internexin neuronal intermediate filament protein, a... 97 5e-20
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 95 1e-19
gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo ... 94 4e-19
gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo ... 94 4e-19
gi|157738619 smoothelin-like 1 [Homo sapiens] 92 9e-19
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 92 2e-18
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 90 5e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 87 5e-17
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 87 5e-17
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 87 5e-17
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 87 5e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 86 7e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 86 7e-17
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 86 1e-16
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 85 1e-16
gi|148746195 trichohyalin [Homo sapiens] 85 1e-16
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 84 3e-16
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 1040 bits (2688), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 60
MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI
Sbjct: 377 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 436
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE
Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE
Sbjct: 497 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 556
Query: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP
Sbjct: 557 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616
Query: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE
Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 676
Query: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 360
KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES
Sbjct: 677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 736
Query: 361 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR
Sbjct: 737 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 796
Query: 421 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 480
KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK
Sbjct: 797 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 856
Query: 481 TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540
TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD
Sbjct: 857 TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 916
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 1040 bits (2688), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 60
MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI
Sbjct: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 60
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE
Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
Query: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
Query: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
Query: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 360
KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES
Sbjct: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 360
Query: 361 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR
Sbjct: 361 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
Query: 421 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 480
KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK
Sbjct: 421 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 480
Query: 481 TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540
TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD
Sbjct: 481 TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 218 bits (556), Expect = 9e-57
Identities = 198/553 (35%), Positives = 281/553 (50%), Gaps = 62/553 (11%)
Query: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 60
MA LREYQDLLNVKMALDIEIAAYRKLLEGEE R GP+ P ++ +
Sbjct: 378 MAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGF------GPI-----PFSLPEGL 426
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
K + +KV+ + +++E+++ E E + T +TEE+ +EE+KEA EE+
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVT---EEEEKEAKEEEG 483
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
+E E EEE A + P + EKE + +EE + AKS + EE S E
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 181 GSSEKEEGE--QEEGETEAEA---EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
S ++ +EE ++ EA E EEA++ E K EK++ A KEE + A+ + PE
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA-KEEAKSPAEAKSPE 602
Query: 236 KAKSPVPKSPVEEKGKSPVP-KSPVEEKGKSPV-------PKSPVEEKGKSP-VPKSPVE 286
KAKSPV +E+ KSP KSPV+E+ KSP KSP +E+ KSP KSP +
Sbjct: 603 KAKSPV-----KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Query: 287 EKGKSP-VSKSPVEEKAKSP-VPKSPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
E+ KSP +KSPV+ +AKSP KSPV+ EAKS + ++E + E ++P +E+ +
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 344 KKEEKPKDVPEK----KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE---- 395
E+ V E+ +KA+SPVKEEA + + L+ ++ E P ++E
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 396 --KEKEKAGGEGGSEEEGSDKGAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKG 452
K EKA EE S + AK KED A E+ KEEV+ KE+ +E +
Sbjct: 778 ADKFPEKAKSP-VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVK-- 834
Query: 453 VVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEE 512
E + E+ KT EK S+ + K K V +K E E
Sbjct: 835 ----------VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKP-KVEEKKEPAVE 883
Query: 513 TFEEKLVSTKKVE 525
+E V KK E
Sbjct: 884 KPKESKVEAKKEE 896
Score = 116 bits (290), Expect = 6e-26
Identities = 137/457 (29%), Positives = 196/457 (42%), Gaps = 73/457 (15%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
K + P E K + K + EE K E E+A + EE E+ K +E
Sbjct: 603 KAKSPVKEEAKSPAEAK--SPVKEEAKSPAEVKSPEKAKSPTKEE--AKSPEKAKSPEKE 658
Query: 119 KEEEPEAEEEEVAAK-KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS 177
+ + PE + V A+ KSP KA +P E + ++ + +EE + E AKS EE S
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Query: 178 -EKEGSSEKEEG---EQEEGETEAEAEG-EEAEAKEEKK-VEEKSEEVAT--KEELVADA 229
EK S KEE E+ + + EA+ E+A++ E+ K ++ KS E T KEE + A
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778
Query: 230 -------------KVEKPEKAKSPVPKS--------PVEEKGKSPV--PKSPVEEKGKSP 266
+V+ PEKAKSP+ + P +E+ KSPV + P E K K P
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838
Query: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326
PK EEK P +P E+ K S EE K PK VEE K A
Sbjct: 839 -PKKAEEEK----APATPKTEEKKD----SKKEEAPKKEAPKPKVEEKKEPA-------- 881
Query: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 386
E PKE KVE K+E+ +D KKK +P KE V+V + + K
Sbjct: 882 -------VEKPKESKVEAKKEEAED---KKKVPTPEKEAPA--------KVEVKEDAKPK 923
Query: 387 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 446
E+ + ++E + KA E+ K KE+ A E + K E + + +K
Sbjct: 924 EKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLS 983
Query: 447 REEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 483
+E K S D+K K EK K +
Sbjct: 984 KEPSKPKAEKAEKSSSTDQK--DSKPPEKATEDKAAK 1018
Score = 110 bits (276), Expect = 2e-24
Identities = 132/487 (27%), Positives = 205/487 (42%), Gaps = 91/487 (18%)
Query: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSP 136
V + E + + E ++ L + EE + EAA+ + + +EE+ +
Sbjct: 267 VTSALREIRAQLEGHAVQSTLQS--EEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQ 324
Query: 137 VKATAPEVKEEEGEKEEEEGQEEEEEE---------DEGAKSDQAEEGGSEKEGSSEKE- 186
++A E++ + K+ E Q E E+ E + AE ++ E +++
Sbjct: 325 LQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLRE 384
Query: 187 ----------------------EGEQ------------EEGETEAEAEGEEAEAKEEKK- 211
EGE+ EG + + + K E+K
Sbjct: 385 YQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKI 444
Query: 212 ------------VEEKSEEVATKEELVADAKVE-KPEKAKSPVPKSPVEEKGKSPVPKSP 258
VEE++EE EE+ + + E K E+ K E +G KSP
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 259 VEEKGKSP--VPKSPVEEKGKSPV-PKSPVEEKGKSPV-------SKSPVEEKAKS-PVP 307
E+ SP KSPV+E+ KSP KSP +E+ KSP +KSP +E+AKS P
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 308 KSP-VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP--KDVPEKKKAESPVKE 364
KSP EEAKS AEV E+ + KE ++P E K +K + P ++ +A+SPVKE
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 365 EA--VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG-AKGSRK 421
EA AEV + K+ + TKEE K ++ K EK + + + K AK K
Sbjct: 625 EAKSPAEVKSPEKA-----KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 422 EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV-VVTK 480
V E + E+ + KE+ E+ K V +E K +K++ V K
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV--------KEEAKSPEKAKSPVKEEAK 731
Query: 481 TVEKITS 487
T EK S
Sbjct: 732 TPEKAKS 738
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 131 bits (330), Expect = 1e-30
Identities = 133/480 (27%), Positives = 214/480 (44%), Gaps = 62/480 (12%)
Query: 53 PITISSKIQKPKVEAPKLK----------VQHKFVEEIIEETKVEDEKSEMEEALTA-IT 101
P T +VE P+ K ++ + VE E KV + E E L+ +T
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
Query: 102 EELAVSMKEEKKEAAEEKEEEPEAE---------------EEEVAAKKSPVKATAPEVKE 146
++ VS E K ++ E E+ PE ++E K K +
Sbjct: 632 DKAEVS--EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP 689
Query: 147 EEGEKE------------EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEE-- 192
EGEKE EE+ Q+E E+ + ++ + EEGG E+ G E+EEG++EE
Sbjct: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
Query: 193 ---GETEAEAEGEEAEAKEEKKV-EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 248
GE + E EGEE E + EK+ E K EE A KEE + + ++ E + E+
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE-KGEEEGDQGEGEEEETEGRGEEK 808
Query: 249 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE-KGKSPVSKSPVEEKAKSPVP 307
+ V VEE GK + E +G+ + EE +G+ + EE+ +
Sbjct: 809 EEGGEVEGGEVEE-GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
Query: 308 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
+ EE + + E +GE + EEE E E +EE + EE+ + E+++ E +EE
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Query: 368 AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK------ 421
+ ++ + EG+ + E E E+ GEG EEEG +G +G +
Sbjct: 927 EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
Query: 422 --EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD----LSPADEKKGGDKSEEK 475
E GE EG+EE E E + +G G EEE+G V ++ +E++G ++ EE+
Sbjct: 987 EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER 1046
Score = 127 bits (319), Expect = 3e-29
Identities = 140/441 (31%), Positives = 199/441 (45%), Gaps = 82/441 (18%)
Query: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE 146
E+E E EE EE + E KE E +E E E E+EE KK + +E
Sbjct: 732 EEEHGEGEEEEGDREEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE 789
Query: 147 E----EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202
E EGE+EE EG+ EE+EE + + EEG E+E E+ EGE+EEGE E E EGE
Sbjct: 790 EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE-EEEGE 848
Query: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 262
E + E K EE+ EE +EE E+ + + E +G+ EE+
Sbjct: 849 GEEEEGEGKGEEEGEEGEGEEE---------GEEGEGEGEEEEGEGEGEEEGEGEGEEEE 899
Query: 263 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 322
G + EE+G+ + E KG EE+ + + EE + + E G+
Sbjct: 900 G-----EGEGEEEGEGEGEEEEGEGKG---------EEEGEEGEGEGEEEEGEGEGEDGE 945
Query: 323 GEQKEEE-----EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
GE +EEE E+E E EE+ E + E+ + E+++ E +EE
Sbjct: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE------------ 993
Query: 378 KVHLEKETKEEGKPLQQEKEKEKAG-GEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK--- 433
E +EEG ++E E E+ G GEG EEEG V GEVEG+
Sbjct: 994 ------EGEEEG---EEEGEGEEEGEGEGEEEEEGE-------------VEGEVEGEEGE 1031
Query: 434 -EEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG-----GDKSEEKV--VVTKTVEKI 485
E E+E +E+G RE+E N + +E++G G++ E+ K V KI
Sbjct: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKI 1091
Query: 486 TSEGGDGATK-YITKSVTVTQ 505
G K Y KSVT TQ
Sbjct: 1092 KGSVKYGKHKTYQKKSVTNTQ 1112
Score = 107 bits (268), Expect = 2e-23
Identities = 114/376 (30%), Positives = 171/376 (45%), Gaps = 62/376 (16%)
Query: 82 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATA 141
EE + E E EE E+ EE K EE+EEE E EEEE
Sbjct: 797 EEEETEGRGEEKEEG-----GEVEGGEVEEGKGEREEEEEEGEGEEEEGEG--------- 842
Query: 142 PEVKEEEGEKEEEEGQ-EEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE---QEEGETEA 197
E +E EGE+EE EG+ EEE EE EG EE G E EG E+EEGE +EEGE E
Sbjct: 843 -EEEEGEGEEEEGEGKGEEEGEEGEG------EEEGEEGEGEGEEEEGEGEGEEEGEGEG 895
Query: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
E E E E +EE + E + EE K E E+ E+ + + E +G
Sbjct: 896 EEEEGEGEGEEEGEGEGEEEEGEGKGE-------EEGEEGEGEGEEEEGEGEG------- 941
Query: 258 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK 317
E G+ + E +G+ + EE+G E + + + EE + +
Sbjct: 942 ---EDGEGEGEEEEGEWEGEEEEGEGEGEEEG---------EGEGEEGEGEGEEEEGEGE 989
Query: 318 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
E +GE++ EEE E +E + E E++E + + E ++ E +EE E +
Sbjct: 990 GEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE-----EGE 1044
Query: 378 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE-GKEEV 436
+ E E +E + ++E+E+E E G EE G + K+ + G V+ GK +
Sbjct: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE--YKKVSKIKGSVKYGKHKT 1102
Query: 437 EQE---TKEKGSGREE 449
Q+ T +G+G+E+
Sbjct: 1103 YQKKSVTNTQGNGKEQ 1118
Score = 101 bits (252), Expect = 2e-21
Identities = 105/359 (29%), Positives = 161/359 (44%), Gaps = 37/359 (10%)
Query: 82 EETKVE-DEKSEMEEALTAITEELAVSMKEEKKEA-AEEKEEEPEAEEEEVAAKKSPVKA 139
EET+ +EK E E EE +EE++E EE+E E E EE E ++ K
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKG 858
Query: 140 TAPEVKEEEGEKEEEEGQ-EEEEEEDEGAKSDQAEEGGSEKEGSSEKE-----EGEQEEG 193
E +E EGE+E EEG+ E EEEE EG ++ E G E+EG E E EGE+EEG
Sbjct: 859 -EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917
Query: 194 ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 253
E + E EGEE E + E++ E E E + + E E+ + E +G+
Sbjct: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
Query: 254 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 313
+ EE+G+ + EE+G EE+G+ EE+ + + E
Sbjct: 978 EGEGE-EEEGEGEGEEEEGEEEG---------EEEGEG-------EEEGEGEGEEEEEGE 1020
Query: 314 AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKE--------- 364
+ + E +GE + EEE+ +E + EK + EE ++ E+++ E +E
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
Query: 365 --EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 421
E +V I SVK K +++ Q KE+ + G GS+K
Sbjct: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKK 1139
Score = 100 bits (250), Expect = 3e-21
Identities = 92/279 (32%), Positives = 134/279 (48%), Gaps = 27/279 (9%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE--EPEAEEEEVAAKKS 135
EE EE + E+E+ E EE EE EE+ E E +EE E E E EE +
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886
Query: 136 PVKATAPEVKEEEGEKE-EEEGQ-EEEEEEDEGAKSDQAEEG---GSEKEGSSEKE---- 186
+ E +EEEGE E EEEG+ E EEEE EG ++ EEG G E+EG E E
Sbjct: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946
Query: 187 EGEQEEGETEAEAEGEEAEAKEEKKVE-EKSEEVATKEELVADAKVEKPEKAKSPVPKSP 245
EGE+EEGE E E E E E +EE + E E+ E +EE + + E+ E+ +
Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006
Query: 246 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
E +G+ EE+ + V E+G+ + EE+G+ + EE ++
Sbjct: 1007 EEGEGEG-------EEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRN- 1058
Query: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 344
+ + E GK ++ EEE E ++ + +KV K
Sbjct: 1059 -------REEEEEEEGKYQETGEEENERQDGEEYKKVSK 1090
Score = 85.5 bits (210), Expect = 1e-16
Identities = 109/380 (28%), Positives = 165/380 (43%), Gaps = 61/380 (16%)
Query: 129 EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
E + K SPV+ + + GE ++ E ++ SD+ EE KEG + K+
Sbjct: 512 EKSLKLSPVQKQKKQ--QTIGELTQDTALTENDD------SDEYEEMSEMKEGKACKQHV 563
Query: 189 EQ----------------EEGETEAEAEGEE---AEAKEEKKVEEKSEEVAT------KE 223
Q EE E E EG E EE++VE E V K
Sbjct: 564 SQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKT 623
Query: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283
E+++D +K E ++ E G EE G S EE+ K
Sbjct: 624 EILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEE-GSSGAEHWQDEEREKGE---- 678
Query: 284 PVEEKGKSPVSKSPVEEK--AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 341
++KG+ + + EK A+ K E + + E +G QKE + E++E +EE
Sbjct: 679 --KDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ-EMEEGGEEEH 735
Query: 342 VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE-KEK 400
E +EE+ D E+++ E KEE E +V E+E KEEG+ ++E+ KE+
Sbjct: 736 GEGEEEE-GDREEEEEKEGEGKEEGEGE--------EVEGERE-KEEGERKKEERAGKEE 785
Query: 401 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE-----QETKEKGSGREEE-KGVV 454
G E G + EG ++ +G R E+ GEVEG E E +E +E+G G EEE +G
Sbjct: 786 KGEEEGDQGEGEEEETEG-RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844
Query: 455 TNGLDLSPADEKKGGDKSEE 474
G E KG ++ EE
Sbjct: 845 EEGEGEEEEGEGKGEEEGEE 864
Score = 81.6 bits (200), Expect = 2e-15
Identities = 73/210 (34%), Positives = 96/210 (45%), Gaps = 32/210 (15%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
EE E + E+E+ E E EE EE + EE+E E E EEEE
Sbjct: 949 EEEEGEWEGEEEEGEGEG------EEEGEGEGEEGEGEGEEEEGEGEGEEEE-------- 994
Query: 138 KATAPEVKEEEGEKEEE---EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194
E EEEGE EEE EG+EEEE E EG E G E EG E+EEGE+E E
Sbjct: 995 ---GEEEGEEEGEGEEEGEGEGEEEEEGEVEG------EVEGEEGEGEGEEEEGEEEGEE 1045
Query: 195 TEAEAEGE------EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 248
E E EGE E E +EE K +E EE +++ KV K + + ++
Sbjct: 1046 REKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQK 1105
Query: 249 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKS 278
K + + E++ K PV + + G S
Sbjct: 1106 KSVTNTQGNGKEQRSKMPVQSKRLLKNGPS 1135
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 118 bits (296), Expect = 1e-26
Identities = 78/187 (41%), Positives = 110/187 (58%), Gaps = 9/187 (4%)
Query: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS-TFAGSITGPLYTHRPPITISSK 59
MAR+L+EYQDLLNVKMALDIEIAAYRKLLEGEETR S T GSIT Y+ + S
Sbjct: 365 MARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSG-YSQSSQVFGRSA 423
Query: 60 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 119
+ + + + + V++E+ E+EE + A E A + EA EE+
Sbjct: 424 YGGLQTSSYLMSTRS---FPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEE 480
Query: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
+++ EAEEEE A ++ K + E KEEE E EEG+E +E E+E ++ EG E+
Sbjct: 481 KDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEE----EKKVEGAGEE 536
Query: 180 EGSSEKE 186
+ + +K+
Sbjct: 537 QAAKKKD 543
Score = 53.1 bits (126), Expect = 6e-07
Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 1/96 (1%)
Query: 144 VKEEEGEKEEE-EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202
V+EE+ E EE E + EE +DE +AEE +KE + E+E E+EE E E +
Sbjct: 447 VQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAK 506
Query: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
E E E + E+++E +E+ V A E+ K K
Sbjct: 507 EEEEGGEGEEGEETKEAEEEEKKVEGAGEEQAAKKK 542
Score = 47.0 bits (110), Expect = 4e-05
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 33/123 (26%)
Query: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 386
+EE+ EV+E + K E+ +++P P + +AE K++ AE E+E
Sbjct: 448 QEEQIEVEETIEAAKAEEAKDEP---PSEGEAEEEEKDKEEAE------------EEEAA 492
Query: 387 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 446
EE + ++E E+ K EGG EEG E KE E+E K +G+G
Sbjct: 493 EEEEAAKEESEEAKEEEEGGEGEEGE------------------ETKEAEEEEKKVEGAG 534
Query: 447 REE 449
E+
Sbjct: 535 EEQ 537
Score = 46.6 bits (109), Expect = 6e-05
Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 11/102 (10%)
Query: 157 QEEEEEEDEGAKSDQAEEGGSE--KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
QEE+ E +E ++ +AEE E EG +E+EE ++EE E E AE EEA +E
Sbjct: 448 QEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEA-------AKE 500
Query: 215 KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK 256
+SEE +EE + E+ ++A+ K VE G+ K
Sbjct: 501 ESEEAKEEEEGGEGEEGEETKEAEEEEKK--VEGAGEEQAAK 540
Score = 42.7 bits (99), Expect = 8e-04
Identities = 61/317 (19%), Positives = 118/317 (37%), Gaps = 39/317 (12%)
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE----------- 114
E +L+ Q ++ + +E + + S + + A E+LA + +E
Sbjct: 230 EIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTE 289
Query: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
+A + + A ++EV+ + +KA E++ G E E Q +E E+ + A ++
Sbjct: 290 SAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQD 349
Query: 175 GGSEKEGSSEKEEGEQEEGETEAE-------------------AEGEEAEAKEEKKVEEK 215
++ E + E E + EGEE V
Sbjct: 350 TINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTS-VGSI 408
Query: 216 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 275
+ + ++ + + + + S V + +E + + + EE
Sbjct: 409 TSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVE--ETIEAAKAEEA 466
Query: 276 GKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE------QKEEE 329
P + EE+ K E + K EEAK + E G+GE + EEE
Sbjct: 467 KDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEE 526
Query: 330 EKEVKEAPKEEKVEKKE 346
EK+V+ A +E+ +KK+
Sbjct: 527 EKKVEGAGEEQAAKKKD 543
Score = 40.0 bits (92), Expect = 0.005
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 309 SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 368
S V+E + + E K EE K+ E P E + E++E+ ++ E++ AE +EEA
Sbjct: 445 SHVQEEQIEVEETIEAAKAEEAKD--EPPSEGEAEEEEKDKEEAEEEEAAE---EEEAAK 499
Query: 369 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
E K + E E EE K ++E++K EG EE+ + K
Sbjct: 500 EESEEAKEEEEGGEGEEGEETKEAEEEEKKV----EGAGEEQAAKK 541
Score = 34.7 bits (78), Expect = 0.23
Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 13/102 (12%)
Query: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKK 357
VEE ++ + +E S+ E + E+K++EE E +EA +EE+ KEE + E++
Sbjct: 454 VEETIEAAKAEEAKDEPPSEGEAEE-EEKDKEEAEEEEAAEEEEA-AKEESEEAKEEEEG 511
Query: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 399
E EE TK + E+E K EG +Q +K+
Sbjct: 512 GEGEEGEE--------TKEAE---EEEKKVEGAGEEQAAKKK 542
Score = 30.8 bits (68), Expect = 3.3
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 1/87 (1%)
Query: 409 EEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG 468
EE + K++ GE E +EE ++E E+ EEE+ + +E
Sbjct: 455 EETIEAAKAEEAKDEPPSEGEAE-EEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGE 513
Query: 469 GDKSEEKVVVTKTVEKITSEGGDGATK 495
G++ EE + +K+ G + A K
Sbjct: 514 GEEGEETKEAEEEEKKVEGAGEEQAAK 540
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 109 bits (273), Expect = 6e-24
Identities = 114/437 (26%), Positives = 195/437 (44%), Gaps = 47/437 (10%)
Query: 65 VEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE 124
+EAP+ + + + E +E + E + E E +E++ E + + E E PE
Sbjct: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894
Query: 125 AEEEEVAAKKSPVKATAPEV-KEEEGEKEEEEGQE---EEEEEDEGAKSDQAEEGGSEKE 180
AE E + A APE KE + E E E E E+E E EGA++ +AEE E E
Sbjct: 1895 AEWE---VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAE 1951
Query: 181 GSS--EKEEGEQEEGETEAEAEGEEAEAKE--------EKKVEEKSEEVATKEELVADAK 230
G + E E E +E E EA+ E E+ EA E E + + +SE+V E A+ +
Sbjct: 1952 GQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPE---AEGE 2008
Query: 231 VEKPEKAKSP-------VPKSPVEE--KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 281
+++ E+ P PKS EE + + K+ + + +S ++P E+
Sbjct: 2009 MQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAE 2068
Query: 282 KSPVEEKGKSPVSKSPV---EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 338
E +G++ V E + ++ VE +++ E K E E E E + P+
Sbjct: 2069 GEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPE 2128
Query: 339 EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 398
E +E E + + PE + E+ ++A E ++ ++ +E +EE +P + E
Sbjct: 2129 SEGIEAPEAEGEAQPESEGVEA---QDAEGEAQPESEGIEA---QEAEEEAQPELEGVEA 2182
Query: 399 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGL 458
+A GE E EG + + + + E+EG E E E + + E +GV T
Sbjct: 2183 PEAEGEAQPESEGIE-----APEAEGEAQPELEGVEAPEAEEE----AQPEPEGVETPEA 2233
Query: 459 DLSPADEKKGGDKSEEK 475
+ E +G + E+K
Sbjct: 2234 EGEAQPESEGETQGEKK 2250
Score = 100 bits (250), Expect = 3e-21
Identities = 100/384 (26%), Positives = 169/384 (44%), Gaps = 23/384 (5%)
Query: 66 EAPKLKVQHKFVEEIIE--ETKVEDEK----SEMEEALTAITEELAVSMKEEKKEAAEEK 119
EAP+ + + + E +E ET+ EDE +E +EA A E + E + ++E
Sbjct: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966
Query: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
EEE + E E+V A + V E +E EGE + E ++ E E EG + EE E
Sbjct: 1967 EEEAQPESEDVEALEVEV-----ETQEAEGEAQPES-EDVEAPEAEGEMQEAEEEAQPES 2020
Query: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
+G + + E EE + E EGE + + + + E E EE +A+ E E
Sbjct: 2021 DGVEAQPKSEGEEAQ---EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGE 2077
Query: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
P+S + ++ P E ++P + ++ P++ E + +S ++P
Sbjct: 2078 AHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEA 2137
Query: 300 EKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
E P + ++A+ +A+ + E E +E E + P+ E VE E + + PE +
Sbjct: 2138 EGEAQPESEGVEAQDAEGEAQ-PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI 2196
Query: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 418
E+P EA E + V+ E +EE +P + E +A GE E EG +G K
Sbjct: 2197 EAP---EAEGEAQPELEGVEA---PEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250
Query: 419 SRKEDIAVNGEVEGKEEVEQETKE 442
+ +G+ E E E
Sbjct: 2251 GSPQVSLGDGQSEEASESSSPVPE 2274
Score = 97.8 bits (242), Expect = 2e-20
Identities = 120/478 (25%), Positives = 208/478 (43%), Gaps = 46/478 (9%)
Query: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 112
P + ++ Q+ + A + + Q + E+IE + E+E E + A+ E+ E +
Sbjct: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
Query: 113 KEAAEEKEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 166
+ E E PEAE EEE + V+A + K E E +E EG+ ++ E D
Sbjct: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA---QPKSEGEEAQEVEGETQKTEGDAQ 2049
Query: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE-EKKVEEKSEEVATKEEL 225
+SD E +E+E +++ EGE +E E EA E E+ +A+E E + + +SE V E
Sbjct: 2050 PESDGVEAPEAEEE--AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE-- 2105
Query: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK--SPVPKS 283
A+ + +K E ++ P++ E + +S ++P E +G++ VE + P+S
Sbjct: 2106 -AEGEAQKAEGIEA--PETEGEAQPESEGIEAP-EAEGEAQPESEGVEAQDAEGEAQPES 2161
Query: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
E ++ P E ++P + + E + E + + E E EAP+ E+
Sbjct: 2162 EGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEA 2221
Query: 344 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITK-SVKVHL----EKETKEEGKPLQQEK-- 396
+ E + + PE AE + E+ E K S +V L +E E P+ +++
Sbjct: 2222 QPEPEGVETPE---AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPT 2278
Query: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-------EDIAVNGEVEGKEEVEQETKEKGSGREE 449
GG+ + GS G SR + + N V G + + K G+ E
Sbjct: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLG-DTRSPDAKSTGTPHAE 2337
Query: 450 EKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 507
K T S E+ EE + ++T E+ SEG D S+ T+ V
Sbjct: 2338 RK--ATRMYPESSTSEQ------EEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAV 2387
Score = 93.2 bits (230), Expect = 5e-19
Identities = 107/432 (24%), Positives = 178/432 (41%), Gaps = 32/432 (7%)
Query: 88 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK-E 146
D+ + I A + + E E E E +A+E E A+ APE + E
Sbjct: 1823 DQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE 1882
Query: 147 EEGEKEEEEGQEEEEE---EDEGAKSDQAEEGGSEKEGSSE--KEEGEQEEGETEAEAEG 201
+ E E+ E E E E E EGA++ +AE+ + S E + EGE E AEA+
Sbjct: 1883 AQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQE 1942
Query: 202 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
E A+E + + EV +E +A+ E + V E +G++ VE
Sbjct: 1943 AEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEA 2002
Query: 262 -----KGKSPVPKSPVEEKGKSPVPKSPVE-------EKGKSPVSKSPVEEKAKSPVPKS 309
+ + ++ E G PKS E E K+ P + ++P +
Sbjct: 2003 PEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEE 2062
Query: 310 PVEEAKSKAEVGKGE-QKEEEEKEVKEAPKEEKVEKK-EEKPKDVPEKKKAESPVKEEAV 367
+EA+ + + +GE E E+ + +EA E + E + E P+ E +KAE E
Sbjct: 2063 EAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETE 2122
Query: 368 AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVN 427
E ++ ++ E + E +P + E + A GE E EG + +++ +
Sbjct: 2123 GEAQPESEGIEA---PEAEGEAQPESEGVEAQDAEGEAQPESEGIE-----AQEAEEEAQ 2174
Query: 428 GEVEGKE--EVEQETKEKGSGRE--EEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 483
E+EG E E E E + + G E E +G L+ A E + + E + V T E
Sbjct: 2175 PELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE 2234
Query: 484 KITSEGGDGATK 495
+G T+
Sbjct: 2235 GEAQPESEGETQ 2246
Score = 87.4 bits (215), Expect = 3e-17
Identities = 90/361 (24%), Positives = 157/361 (43%), Gaps = 26/361 (7%)
Query: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK-EEEGEKEEEEGQEEEEEED-E 165
+ +K E E + A+E E S A + + E+EGE E G+ + E
Sbjct: 1752 LNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHE 1811
Query: 166 GAKSDQAEEGGSEKEGSSEKEEG---EQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
+A GG + G S+ EG + EGE + E+EG EA E E + E
Sbjct: 1812 DNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPES 1871
Query: 223 EELVA-DAKVE-KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS--PVEEKGKS 278
E++ A +A+ E +PE P++ E + +S ++P EK P +S +E +G+
Sbjct: 1872 EDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGED 1931
Query: 279 PVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 338
P E ++ ++ +E P+S V E++ E + E ++ E EV
Sbjct: 1932 ----EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV----- 1982
Query: 339 EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ-EKE 397
+VE +E + + PE + E+P E + E + +E + K EG+ Q+ E E
Sbjct: 1983 --EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040
Query: 398 KEKAGGEGGSEEEG-----SDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 452
+K G+ E +G +++ A+ + E GE + E + +G + E +G
Sbjct: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
Query: 453 V 453
V
Sbjct: 2101 V 2101
Score = 72.8 bits (177), Expect = 8e-13
Identities = 90/383 (23%), Positives = 155/383 (40%), Gaps = 40/383 (10%)
Query: 118 EKEEEPEAEEEEVAAKKSPVKATA------------PEVKEEEGEKEEEEGQEEEE-EED 164
++ E + E EVA K+ T+ P + + G E E+G+ + D
Sbjct: 1696 KRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRD 1755
Query: 165 EGAKSDQAEEGG--SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
+ K +AE E+EG + E EAE EGE + E + E +
Sbjct: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
Query: 223 EELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 282
E A + + + ++P E +G++ P E ++P + +E P+
Sbjct: 1816 GEAAAGGDQDPGQSDGAEGIEAP-EAEGEA----QPESEGVEAPEAEGDAQEAEGEAQPE 1870
Query: 283 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 342
S E ++ P E ++P + V+ +G + E EKE + P+ E V
Sbjct: 1871 SEDVEAPEAEGEAQPESEDVETPEAEWEVQPE------SEGAEAPEAEKEAQ--PETESV 1922
Query: 343 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE-KETKEEGKP-------LQQ 394
E E + +D PE + AE+ EEA E T+ +E +E +EE +P L+
Sbjct: 1923 EALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV 1982
Query: 395 EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVV 454
E E ++A GE E E + ++ + E + VE + K +G +E +G
Sbjct: 1983 EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE-SDGVEAQPKSEGEEAQEVEGET 2041
Query: 455 --TNGLDLSPADEKKGGDKSEEK 475
T G D P + ++EE+
Sbjct: 2042 QKTEG-DAQPESDGVEAPEAEEE 2063
Score = 53.5 bits (127), Expect = 5e-07
Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 20/215 (9%)
Query: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
A E+E E + EE A + + V+EE +E +EG E E ++E Q EE
Sbjct: 1268 ACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV---QLEE 1324
Query: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
+E+ +EEG Q E E E EG++ E + +++EE E +E + + E P
Sbjct: 1325 TKTEE---GLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP 1381
Query: 235 EKA-KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV--EEKGKS 291
E + + ++E+G +E ++ P GK PV EE G++
Sbjct: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSP------DGKGSQEDDPVQEEEAGRA 1435
Query: 292 PVSKSP-----VEEKAKSPVPKSPVEEAKSKAEVG 321
S P EE + P S + + S+ + G
Sbjct: 1436 SASAEPCPAEGTEEPTEPPSHLSETDPSASERQSG 1470
Score = 51.6 bits (122), Expect = 2e-06
Identities = 66/250 (26%), Positives = 107/250 (42%), Gaps = 39/250 (15%)
Query: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE-EEPEAEEEEVAAKKSPVKATAPEVK 145
E E+ E+ ++ E+LA + +E+ + E KE E E +EE + E K
Sbjct: 1275 EAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE--------ETK 1326
Query: 146 EEEGEKEE-------EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 198
EEG +EE +E + E ++E+E A+ ++ EE G G +EEG Q E E
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEGQQEEE-AQLEEIEETG----GEGLQEEGVQLEEVKEGP 1381
Query: 199 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 258
G + EA EE EE E + ++ +A SP K E+ PV +
Sbjct: 1382 EGGLQGEALEEGLKEEGLPEEGS-------VHGQELSEASSPDGKGSQED---DPVQE-- 1429
Query: 259 VEEKGKS-----PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 313
EE G++ P P EE + P S + S S +E + P + + +
Sbjct: 1430 -EEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQ 1488
Query: 314 AKSKAEVGKG 323
++A+ +G
Sbjct: 1489 EHTQAQPTQG 1498
Score = 50.8 bits (120), Expect = 3e-06
Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 24/217 (11%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK----EAAEEKEEEPEAEEEEVAAK 133
E+ E E S E L T + V ++E K+ E +E+ + E + E +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 134 KSPVKATAPEVKEEEGEKEEEEGQEEEEE------EDEGAKSDQAE---EGGSEKEGSSE 184
+ V+ + E EG++EEE EE EE ++EG + ++ + EGG + E E
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
Query: 185 --KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
KEEG EEG + E EA + + K +E ++ V + + + + P P
Sbjct: 1393 GLKEEGLPEEGSVHGQ-ELSEASSPDGKGSQE--------DDPVQEEEAGRASASAEPCP 1443
Query: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 279
EE + P S + S +E + P
Sbjct: 1444 AEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKP 1480
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 27/201 (13%)
Query: 36 FSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEE 95
F TF + T+ S+ Q+ +L E +EETK E ++E
Sbjct: 1258 FPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQE 1317
Query: 96 ALTAITE-ELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 154
+ E + ++EE + E KE E E ++EE +A E++E GE +E
Sbjct: 1318 EAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQE 1369
Query: 155 EG---QEEEEEEDEGAKSDQAEEG----GSEKEGSSEKEE----------GEQEEGETEA 197
EG +E +E + G + + EEG G +EGS +E G QE+ +
Sbjct: 1370 EGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQE 1429
Query: 198 EAEGEEAEAKEEKKVEEKSEE 218
E G A A E E +EE
Sbjct: 1430 EEAG-RASASAEPCPAEGTEE 1449
Score = 45.4 bits (106), Expect = 1e-04
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 23/173 (13%)
Query: 315 KSKAEVGKGEQKEEEEKE-VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 373
+ +AE EQ+ E + E +E+V+ +E K E + E+ EE E
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 374 TKSVKVHLEKETKEEGKPLQ--QEKEKEKAGGEGGSEE--------EGSDKGAKGS---- 419
+ V++ KET+ EG+ + Q +E E+ GGEG EE EG + G +G
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
Query: 420 --RKEDIAVNGEVEGKEEVEQETKE-KGSG-----REEEKGVVTNGLDLSPAD 464
++E + G V G+E E + + KGS +EEE G + + PA+
Sbjct: 1393 GLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAE 1445
Score = 40.8 bits (94), Expect = 0.003
Identities = 45/224 (20%), Positives = 97/224 (43%), Gaps = 13/224 (5%)
Query: 269 KSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE 328
++ V+E+ + K E +G + E K + + + V+ ++K G+G+Q+EE
Sbjct: 1294 ENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEE 1353
Query: 329 EE-KEVKEAPKE------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 381
+ +E++E E ++E+ +E P+ + + E +KEE + E ++ L
Sbjct: 1354 AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQ---EL 1410
Query: 382 EKETKEEGKPLQQEK--EKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 439
+ + +GK Q++ ++E+AG S E +G + E + E + Q
Sbjct: 1411 SEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTE-EPTEPPSHLSETDPSASERQS 1469
Query: 440 TKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 483
+ G E+ G G + + A +G + V + ++
Sbjct: 1470 GSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALD 1513
Score = 35.4 bits (80), Expect = 0.13
Identities = 60/258 (23%), Positives = 99/258 (38%), Gaps = 30/258 (11%)
Query: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE-APKEEKVEKKEEKPKDVPE 354
SP+ KA + P++EA ++ + ++ E + E E AP + + + E
Sbjct: 1668 SPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAE 1727
Query: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEKETK---EEGKPLQQEKE------KEKAGGE- 404
+ V E S +++ +K+ K EG + QE+E + AG E
Sbjct: 1728 GGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSEL 1787
Query: 405 GGSEEEG------SDKGAKGSRKEDIAVN----------GEVEGKEEVEQETKEKGSGRE 448
G +E+EG + G +GS ED G+ +G E +E E G +
Sbjct: 1788 GEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAE-GEAQP 1846
Query: 449 EEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE-KITSEGGDGATKYITKSVTVTQKV 507
E +GV + A E +G + E + V E + E D T V +
Sbjct: 1847 ESEGVEAPEAE-GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
Query: 508 EEHEETFEEKLVSTKKVE 525
E E +E T+ VE
Sbjct: 1906 AEAPEAEKEAQPETESVE 1923
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 108 bits (271), Expect = 9e-24
Identities = 159/534 (29%), Positives = 224/534 (41%), Gaps = 60/534 (11%)
Query: 21 EIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKP---KVEAPKLKVQHKFV 77
E Y + E E R+ IT P PI + ++P K +AP KV K V
Sbjct: 9764 EYDQYEEYEEREYERYEEHEEYITEP----EKPIPVKPVPEEPVPTKPKAPPAKVLKKAV 9819
Query: 78 EE------IIEETKVEDEKSEMEEALTAITEELAVSM-KEEKKEAAEEKEEEPEAEEEEV 130
E I ++ K K EE E++ +S+ K EK++ E + P + V
Sbjct: 9820 PEEKVPVPIPKKLKPPPPKVP-EEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVV 9878
Query: 131 AAKKSPV--KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
A +K PV K AP V+ E KE E + EEE + E E+E E+EE
Sbjct: 9879 AEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVE--EEEEYIHEEEEF 9936
Query: 189 EQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV-- 246
EE E + E + EEK K++ AKV PE K P K PV
Sbjct: 9937 ITEE-EVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKV--PEVPKKPEEKVPVLI 9993
Query: 247 EEKGKSP------VPKSPV-EEKGKSPVPKSPVEEKGKSP-VPKSPVEEKGKSPVSKSPV 298
+K K P VPK PV EEK PVPK K P VPK PV EK K PV P
Sbjct: 9994 PKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEK-KVPV---PA 10049
Query: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
+K ++P K P K E E+K + EAP + +K+E P V ++
Sbjct: 10050 PKKVEAPPAKVPEVPKKLIPE----EKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEE 10105
Query: 359 ESPVKEEAVAEVVTITKSVKVHLEKE--TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGA 416
E +EE V E + + +V E+E EE + L +E+E E EEE +
Sbjct: 10106 EVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEE 10165
Query: 417 KGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 476
+ +E++ EV+ K V E E+K V+ + PA + K EEK
Sbjct: 10166 EFVPEEEVL--PEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKR 10223
Query: 477 VVTKTVEKITSEGGDGATKYITKSVTVTQKVEEH---EETFEEKLVSTKKVEKV 527
++ E++ V VT++ EE EE E+ S ++VE+V
Sbjct: 10224 IILPKEEEVL-------------PVEVTEEPEEEPISEEEIPEEPPSIEEVEEV 10264
Score = 99.4 bits (246), Expect = 8e-21
Identities = 151/548 (27%), Positives = 225/548 (41%), Gaps = 93/548 (16%)
Query: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 105
P+ + P+ ++ K + P + P+++ + ++ E K+ E A+ E
Sbjct: 9351 PVPEEKIPVPVAKKKEAPPAKVPEVQ------KGVVTEEKITIVTQREESPPPAVPEIPK 9404
Query: 106 VSMKEEKKEAAEEKEEEPEAEE----------EEVAAKKSPVKATAPEVKEEEGEKEE-E 154
+ EE+K ++EE P + EE A PV AP + E +K E
Sbjct: 9405 KKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVE 9464
Query: 155 EGQEEEEEEDEGAKSDQAE----EGGSEKEGS-SEKEEG------EQEEGETEAEAEGEE 203
E + EE+ A + E E +E+E S SE+EEG +EE E E EAE E
Sbjct: 9465 EKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTE 9524
Query: 204 AEAKEE--------------KKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 249
E EE K+VE + EV ++E K + P K + P P + V E
Sbjct: 9525 YEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEP-PPAKVPEA 9583
Query: 250 GKSPVPK----SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
K VP+ +PV +K K P PK P E PK PV EK K P +EE +
Sbjct: 9584 PKKIVPEKKVPAPVPKKEKVPPPKVPEE-------PKKPVPEK-KVPPKVIKMEEPLPAK 9635
Query: 306 VPKSPV---EEAKSKAEVGKGE--QKEEEEKEVKEAPKEEKV-----EKKEEKPKDVPEK 355
V + + +E K V K E K +E K A EEKV +++EE P V E
Sbjct: 9636 VTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEF 9695
Query: 356 KK---AESPVKEEAVAEVVTITKSVKVHLEKE----TKEEGKPLQQEKEKEKAGGEGGSE 408
+K E V EA K V + EKE +EE +Q+E+E E E
Sbjct: 9696 RKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYE--------E 9747
Query: 409 EEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG 468
E D E+ E + EE E+ E+ EE + + P E+
Sbjct: 9748 YEEYDY----KEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPV 9803
Query: 469 GDKSEEKVVVTKTVEKITSEGGDGATKYITKSV--TVTQKVEEHEETFEEKL---VSTKK 523
K K K ++K E + I K + + EE ++ FEEK+ ++ ++
Sbjct: 9804 PTK--PKAPPAKVLKKAVPE--EKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKRE 9859
Query: 524 VEKVTSHA 531
E+VT A
Sbjct: 9860 KEQVTEPA 9867
Score = 95.9 bits (237), Expect = 8e-20
Identities = 146/530 (27%), Positives = 218/530 (41%), Gaps = 97/530 (18%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKS----EMEEALTAITEELAVSMKEEKKEAA 116
++P + ++KV+ K +E+ EE + + E+ E EE EE + +E++
Sbjct: 9095 EEPDEDYEEIKVEAK--KEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAY-QEREVIQ 9151
Query: 117 EEKEEEPEAEEEEVAAKKSPVKATAPE--VKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
+KE E+ E +V AK KA P +K+ EK E+ + EEE+ + K + +
Sbjct: 9152 VQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSK 9211
Query: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKK-------------VEEKSEEVAT 221
++ S + E E + A ++ EEK V E +E+ T
Sbjct: 9212 KIVPQKPSRTPVQEEVIEVKVPA-VHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVT 9270
Query: 222 KEEL--VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP-VPKSPV-EEKGK 277
+E++ +VE P K K EE P+PK K P VPK PV EEK
Sbjct: 9271 EEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKP 9330
Query: 278 SPVPKSPVEEKGKSPVSKSPVEEKAKSPVP--KSPVEEAKSK-------AEVGKGEQKEE 328
PVPK K P + V E K PVP K PV AK K EV KG EE
Sbjct: 9331 VPVPK-------KEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEE 9383
Query: 329 E-----EKEVKEAPKEEKVEKKE--EKPKDVPEKKK-----------AESPVKEEAVAEV 370
+ ++E P ++ KK+ E+ K VP K++ + PV EE VA
Sbjct: 9384 KITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVP 9443
Query: 371 VTITKSV---KVHLEKETKEEGKPLQQEKE--------KEKAGGEGGSEEEGSDKGAKGS 419
V + K + + K+T E K E++ E E +EEE S ++
Sbjct: 9444 VPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWS--YSEEE 9501
Query: 420 RKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV-VV 478
I+V E E +EE E E E E E+ VV EEK+ ++
Sbjct: 9502 EGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVV------------------EEKLHII 9543
Query: 479 TKTVEKITSEGGDGATKYITKSVTVTQKVEEHEET----FEEKLVSTKKV 524
+K VE +E + K I + K+EE +K+V KKV
Sbjct: 9544 SKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKV 9593
Score = 89.4 bits (220), Expect = 8e-18
Identities = 107/348 (30%), Positives = 139/348 (39%), Gaps = 57/348 (16%)
Query: 64 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 123
KVEAP KV K EE + V +K +EA A E+ + E KK +KE P
Sbjct: 10287 KVEAPPAKVSKKIPEE---KVPVPVQK---KEAPPAKVPEVPKKVPE-KKVLVPKKEAVP 10339
Query: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE--EEEDEGAKSDQAEEGGSEKEG 181
A+ V +K V V +E E E E + EE EEE+ + EEG +
Sbjct: 10340 PAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVE 10399
Query: 182 SSEKEEGEQEEGETEAEA--------EGEEAEAKEEKKVEEKSEEVATK----------- 222
K E + E E E E EE E E+ K K E++ K
Sbjct: 10400 EFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKV 10459
Query: 223 --------------EELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS----PVEEKGK 264
+++V + KV PE+ + P K P K VP+ P +K +
Sbjct: 10460 VPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPE 10519
Query: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 324
+P PK P K P K PV K V + V E K+ VP+ V EA
Sbjct: 10520 APPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIP-------P 10572
Query: 325 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVK-EEAVAEVV 371
+ E EV EAPKE EKK P KK +PVK EA EVV
Sbjct: 10573 KPESPPPEVPEAPKEVVPEKKVPA---APPKKPEVTPVKVPEAPKEVV 10617
Score = 87.4 bits (215), Expect = 3e-17
Identities = 135/485 (27%), Positives = 189/485 (38%), Gaps = 64/485 (13%)
Query: 61 QKPKV------EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE 114
+KP+V E PK V K V E I K E E+ EA + E V KK
Sbjct: 10544 KKPEVPPTKVPEVPKAAVPEKKVPEAIPP-KPESPPPEVPEAPKEVVPEKKVPAAPPKKP 10602
Query: 115 AAEEKEEEPEAEEEEVAAKKSPV----KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
+ PEA +E V KK PV K P K E K ++ E +S
Sbjct: 10603 EVTPVKV-PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESP 10661
Query: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230
E +E + E+ E E E E A + ++ E+K+ V K+ + K
Sbjct: 10662 PPEVFEEPEEVALEEPPAEVVE-EPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVK 10720
Query: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
V + K P K P+ K P + V E K VP+ V K VP + V E K
Sbjct: 10721 VPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPK 10780
Query: 291 SPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK 350
PV +EEK PVP+ +AE E EE E E EE++ +EEKP
Sbjct: 10781 KPV----LEEKPAVPVPE--------RAESPPPEVYEEPE----EIAPEEEIAPEEEKPV 10824
Query: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET---KEEGKPLQQEKEKEKAGGEGGS 407
V E+++ E P AV E + K+ EK+ K+ P +E E EK E
Sbjct: 10825 PVAEEEEPEVP--PPAVPE-----EPKKIIPEKKVPVIKKPEAPPPKEPEPEKV-IEKPK 10876
Query: 408 EEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKK 467
+ KED+ KE++ Q K + EK V ++L+P +
Sbjct: 10877 LKPRPPPPPPAPPKEDV--------KEKIFQ-LKAIPKKKVPEKPQVPEKVELTPL-KVP 10926
Query: 468 GGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKV 527
GG+K K++ + E K V + V EE V KK+EKV
Sbjct: 10927 GGEKKVRKLLPERKPE--------------PKEEVVLKSVLRKRPEEEEPKVEPKKLEKV 10972
Query: 528 TSHAI 532
A+
Sbjct: 10973 KKPAV 10977
Score = 87.0 bits (214), Expect = 4e-17
Identities = 141/527 (26%), Positives = 217/527 (41%), Gaps = 67/527 (12%)
Query: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 105
P+ + P+ + K++ P + P++ ++ + E KV + EA A E+
Sbjct: 10011 PVPEEKVPVPVPKKVEAPPAKVPEVP------KKPVPEKKVPVPAPKKVEAPPAKVPEVP 10064
Query: 106 VSM-KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE-EE 163
+ EEKK K+ E A +V K+ PV +EEE EEE EEE E
Sbjct: 10065 KKLIPEEKKPTPVPKKVE--APPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPE 10122
Query: 164 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE---GEEAEAKEEKKVEEKSEEVA 220
+E ++ E E+E E+EE EE E E E EE EE+ + E +V
Sbjct: 10123 EEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVP 10182
Query: 221 TK------EELVADAKVEKPEKAKSPVPKSP-----VEEKG------KSPVPKSPVEEKG 263
++ V + KV P+K ++P K P VEEK + +P EE
Sbjct: 10183 VPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPE 10242
Query: 264 KSPV-----PKSP--VEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 316
+ P+ P+ P +EE + P+ P K P + +PV +K ++P K + +
Sbjct: 10243 EEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEE 10302
Query: 317 KAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVK-----EEAVAEVV 371
K V ++KE +V E PK K EK VP KK+A P K EE V+
Sbjct: 10303 KVPV-PVQKKEAPPAKVPEVPK-----KVPEKKVLVP-KKEAVPPAKGRTVLEEKVSVAF 10355
Query: 372 TITKSVKVHLEKETKE-EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV-NGE 429
VK LE E E E + + +E+E + EE ++G +E I +
Sbjct: 10356 RQEVVVKERLELEVVEAEVEEIPEEEEFHEV-------EEYFEEGEFHEVEEFIKLEQHR 10408
Query: 430 VEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEG 489
VE + VE+ + EE V P KG + SE+ + K K+
Sbjct: 10409 VEEEHRVEKVHRVIEVFEAEEVEVFE-----KPKAPPKGPEISEKIIPPKKPPTKVVPRK 10463
Query: 490 GDGA-TKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKE 535
A + K + V +KV E E ++ TK E + +V E
Sbjct: 10464 EPPAKVPEVPKKIVVEEKVRVPE---EPRVPPTKVPEVLPPKEVVPE 10507
Score = 84.7 bits (208), Expect = 2e-16
Identities = 120/428 (28%), Positives = 168/428 (39%), Gaps = 52/428 (12%)
Query: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 105
P+ + P ++ K + P V+ P++ +E++ E KV + EA A E+
Sbjct: 10700 PVPEKKAPAVVAKKPELPPVKVPEVP------KEVVPEKKVPLVVPKKPEAPPAKVPEVP 10753
Query: 106 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165
+ EKK A +K E P A+ EV K PV P V E + E E EE +E
Sbjct: 10754 KEVVPEKKVAVPKKPEVPPAKVPEVP--KKPVLEEKPAVPVPE--RAESPPPEVYEEPEE 10809
Query: 166 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
A EE E+E E E+ E A E + E+K K E +E
Sbjct: 10810 IAPE---EEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEP 10866
Query: 226 VADAKVEKPEKAKSPVPKSPVEEKGK--------SPVPKSPVEEKGKSP--VPKSPV--- 272
+ +EKP+ P P P K +PK V EK + P V +P+
Sbjct: 10867 EPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVP 10926
Query: 273 --EEKGKSPVPKSPVEEKG----KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326
E+K + +P+ E K KS + K P EE+ K V +E+ K A K
Sbjct: 10927 GGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPK--VEPKKLEKVKKPAVPEPPPPK 10984
Query: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA----ESPVKEEAVAEVVTITKSVKVHLE 382
EE EV P K E+K +P VPE K A K + AEV TI +E
Sbjct: 10985 PVEEVEV---PTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPP---PVE 11038
Query: 383 KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG-AKGSRKEDIAVNGEVEGKEEVEQETK 441
E P+ +KA + EE KG KG K + E E+
Sbjct: 11039 PEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPK-------KTPSPIEAERRKL 11091
Query: 442 EKGSGREE 449
GSG E+
Sbjct: 11092 RPGSGGEK 11099
Score = 82.8 bits (203), Expect = 7e-16
Identities = 100/346 (28%), Positives = 143/346 (41%), Gaps = 39/346 (11%)
Query: 64 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 123
K PK +V + + EE ++ + EE +TE +KEEK K E
Sbjct: 9656 KEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQ 9715
Query: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183
+E + +K E + E+E EE +E + +E E E E +
Sbjct: 9716 PIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFE------------EYEPTE 9763
Query: 184 EKEEGEQ-EEGETEAEAEGEEAEAKEEKKVEEK---SEEVATKEELVADAKVEKPEKAKS 239
E ++ E+ EE E E E EE + EK + K E V TK + AKV K +
Sbjct: 9764 EYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPK-APPAKVLKKAVPEE 9822
Query: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE----KGKSPVSK 295
VP P+ +K K P PK P E PK EEK + + K E+ K P+
Sbjct: 9823 KVP-VPIPKKLKPPPPKVPEE-------PKKVFEEKIRISITKREKEQVTEPAAKVPMKP 9874
Query: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE--EKEVKEAPKEEKVEKKEEKPKDVP 353
V + K PVP+ V EV K + EE E+EV +E VE++EE +
Sbjct: 9875 KRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHE-- 9932
Query: 354 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 399
E + EE V V+ + V K EE KP+ K+KE
Sbjct: 9933 ----EEEFITEEEVVPVIPV--KVPEVPRKPVPEEKKPVPVPKKKE 9972
Score = 78.2 bits (191), Expect = 2e-14
Identities = 102/360 (28%), Positives = 143/360 (39%), Gaps = 29/360 (8%)
Query: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 122
PK E+P +V + E +EE E + A +T + E+K A K+ E
Sbjct: 10656 PKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPE 10715
Query: 123 ------PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGG 176
PE +E V KK P+ P+ E K E +E E+
Sbjct: 10716 LPPVKVPEVPKEVVPEKKVPL--VVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPA 10773
Query: 177 SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKPE 235
E + E+ AE E EE + EE+A +EE V A+ E+PE
Sbjct: 10774 KVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPE 10833
Query: 236 KAKSPVPKSP---VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 292
VP+ P + EK K PV K P K P P+ +E+ P P P K
Sbjct: 10834 VPPPAVPEEPKKIIPEK-KVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKED 10892
Query: 293 VSKSPVEEKA--KSPVPKSPVEEAK---SKAEVGKGEQKEEE-EKEVKEAPKEEKVEK-- 344
V + + KA K VP+ P K + +V GE+K + E K PKEE V K
Sbjct: 10893 VKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSV 10952
Query: 345 -----KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 399
+EE+PK P+K + VK+ AV E +V + TK E K + K E
Sbjct: 10953 LRKRPEEEEPKVEPKKLE---KVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPE 11009
Score = 76.6 bits (187), Expect = 5e-14
Identities = 108/420 (25%), Positives = 176/420 (41%), Gaps = 28/420 (6%)
Query: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 105
P+ + P+ + K + P + P++ + + ++ K + +++ E E
Sbjct: 9957 PVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEK 10016
Query: 106 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165
V + KK A + PE ++ V KK PV A P+ E K E ++ EE +
Sbjct: 10017 VPVPVPKKVEAPPAKV-PEVPKKPVPEKKVPVPA--PKKVEAPPAKVPEVPKKLIPEEKK 10073
Query: 166 GAKSDQAEEGGSEKEGSSEKEEG------EQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 219
+ E K + ++EE E E EE EE++V + EEV
Sbjct: 10074 PTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEV 10133
Query: 220 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV--EEKGKSPVPKSPVEEKGK 277
+EE V + E P + + P+ + + VP+ V E K K PVP E K K
Sbjct: 10134 LPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKK 10193
Query: 278 SPVPKSPVEEKGKSPVSKSP-VEEKAKSPVPKSPVEEAKSKAEVGKGEQKE--EEEKEVK 334
K + +K ++P +K P V +K + P EE EV + ++E EE+ +
Sbjct: 10194 VTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPE 10253
Query: 335 EAPKEEKVEKKEEKPKDVPE--KK---KAESPVKEEAVAEVVTITKSV---KVHLEKETK 386
E P E+VE E P VPE KK +A +PV ++ A ++K + KV + + K
Sbjct: 10254 EPPSIEEVE--EVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKK 10311
Query: 387 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG----SRKEDIAVNGEVEGKEEVEQETKE 442
E E K+ + ++ + AKG K +A EV KE +E E E
Sbjct: 10312 EAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVE 10371
Score = 76.6 bits (187), Expect = 5e-14
Identities = 114/411 (27%), Positives = 156/411 (37%), Gaps = 72/411 (17%)
Query: 46 PLYTHRPPITISSKIQKPKV-------EAPKLKVQHKFVEEIIEETKVEDEKSEM----- 93
P PP +S KI + KV EAP KV V + + E KV K E
Sbjct: 10285 PKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPE--VPKKVPEKKVLVPKKEAVPPAK 10342
Query: 94 ------EEALTAITEELAVSMKEEKKEAAEEKEEEPEAEE---EEVAAKKSPVKATAPEV 144
E+ A +E+ V + E + E EE PE EE E ++ +
Sbjct: 10343 GRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFI 10402
Query: 145 KEEEGEKEEEEGQEE--------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 196
K E+ EEE E+ E EE E + +A G E + +
Sbjct: 10403 KLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPR 10462
Query: 197 AEAEGEEAEAKEEKKVEEKSE-------------EVATKEELVADAKVEKP--EKAKSPV 241
E + E ++ VEEK EV +E+V + KV P +K ++P
Sbjct: 10463 KEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPP 10522
Query: 242 PKSPV-------EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 294
PK P E+K P PK P VP + V E VPK+ V EK K P +
Sbjct: 10523 PKVPEAPKEVVPEKKVPVPPPKKP-------EVPPTKVPE-----VPKAAVPEK-KVPEA 10569
Query: 295 KSPVEEKAKSPVPKSPVEEA-KSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 353
P E VP++P E + K ++ E +V EAPKE EKK P P
Sbjct: 10570 IPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVP---P 10626
Query: 354 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
KK P K V +V K V + K E P + +E E+ E
Sbjct: 10627 PKKPEVPPTKVPEVPKVAVPEKKVPEAI--PPKPESPPPEVFEEPEEVALE 10675
Score = 68.2 bits (165), Expect = 2e-11
Identities = 99/368 (26%), Positives = 143/368 (38%), Gaps = 65/368 (17%)
Query: 64 KVEAPKLKVQHKFVEEIIEET-------KVEDEKSEMEEALTAITEELAVSMKEEKK-EA 115
K E P KV + ++EE + E E+ E I E ++ +EEK
Sbjct: 10767 KPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPV 10826
Query: 116 AEEKEEE------PEAEEEEVAAKKSPV--KATAPEVKEEEGEKEEEEGQEEEEEED--- 164
AEE+E E PE ++ + KK PV K AP KE E EK E+ + +
Sbjct: 10827 AEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPP 10886
Query: 165 ----EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE---EKKVEEKSE 217
E K + K+ EK + ++ T + G E + ++ E+K E K E
Sbjct: 10887 APPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPK-E 10945
Query: 218 EVATKEELVADAKVEKP-------EKAKSPV-----PKSPVEE---------KGKSPVPK 256
EV K L + E+P EK K P P PVEE + K P P
Sbjct: 10946 EVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPT 11005
Query: 257 SPVEEK------GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP 310
E K P PK E K P P P +PV+ V +KA++ K+P
Sbjct: 11006 KVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEA---KAP 11062
Query: 311 VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV 370
EEA KG K+ P + E+++ +P EK E+P + A
Sbjct: 11063 KEEAAKPKGPIKGVP--------KKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVP 11114
Query: 371 VTITKSVK 378
+ K +K
Sbjct: 11115 LKFVKEIK 11122
Score = 57.4 bits (137), Expect = 3e-08
Identities = 78/332 (23%), Positives = 122/332 (36%), Gaps = 57/332 (17%)
Query: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETK-----VEDEKSEM------E 94
P+ +P + + + + P E + + EEI E + E+E+ E+ E
Sbjct: 10782 PVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPE 10841
Query: 95 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK--- 151
E I E+ +K K EA KE EPE E+ K P KE+ EK
Sbjct: 10842 EPKKIIPEKKVPVIK--KPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQ 10899
Query: 152 ----EEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207
+++ E+ + ++ + GG +K E + + E ++ + +
Sbjct: 10900 LKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEE 10959
Query: 208 EEKKVEEKS------------------EEVATKEELVADAKVEKPEK-----------AK 238
EE KVE K EEV + K+ +P K A
Sbjct: 10960 EEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAP 11019
Query: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298
P PK E K P P P +PV V +K ++ PK K K P+ P
Sbjct: 11020 EPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEA-AKPKGPIKGVP- 11077
Query: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 330
K+P SP+E + K G G +K +E
Sbjct: 11078 ---KKTP---SPIEAERRKLRPGSGGEKPPDE 11103
Score = 56.2 bits (134), Expect = 7e-08
Identities = 75/342 (21%), Positives = 133/342 (38%), Gaps = 27/342 (7%)
Query: 69 KLKVQHKFVEEIIEET---KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA 125
++ V H+ + + E+T KV ++ +E T I+EE+ K+ +EA ++ E A
Sbjct: 505 QMHVTHEQIRKETEKTFVPKVVISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAA 564
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS---------------D 170
VA KS T P +EE ++++ E+ E K+ D
Sbjct: 565 SMVVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQD 624
Query: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEG------EEAEAKEEKKVEEKSEEVATKEE 224
G E+ + QE+ EAE A+AKE++ + E +AT++E
Sbjct: 625 LVSRGREGITTKREQVQITQEKMRKEAEKTALSTIAVATAKAKEQETILRTRETMATRQE 684
Query: 225 --LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 282
V KV+ +KA++ ++ + P+ P + +S ++ +E K +
Sbjct: 685 QIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREPGHLE-ESYAQQTTLEYGYKERISA 743
Query: 283 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 342
+ V E + P S+ V KA P E K KG + K+ + E V
Sbjct: 744 AKVAEPPQRPASEPHVVPKAVKPRVIQAPSETHIKTTDQKGMHISSQIKKTTDLTTERLV 803
Query: 343 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKE 384
+ P ++ V + +I S L+KE
Sbjct: 804 HVDKRPRTASPHFTVSKISVPKTEHGYEASIAGSAIATLQKE 845
Score = 55.8 bits (133), Expect = 1e-07
Identities = 85/349 (24%), Positives = 145/349 (41%), Gaps = 53/349 (15%)
Query: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 262
EA + E + K ++ K + D++V P VP + P+P +
Sbjct: 8914 EARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPE 8973
Query: 263 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK----SPVEEKAKSPVPKSPVEEAKSKA 318
K P PK + V K V++ K V+K +P EE K P P + + AK+
Sbjct: 8974 EKKPPPK-------RIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAP- 9025
Query: 319 EVGKGEQKEEEEKEVKEAPKEEKVEKKE---EKPKDVPEKKKA-----ESPVKEEAVAEV 370
E+ K EE K + K+E ++KE EK + V ++K+ E P E EV
Sbjct: 9026 EIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDE---LEV 9082
Query: 371 VTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV 430
T+ + +E E+ + ++ E +KE EE ++G + +E
Sbjct: 9083 EPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHE----EWEEDFEEGQEYYERE-------- 9130
Query: 431 EGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGG 490
EG +E E+E +E RE + +K+ ++S E+ V K EK
Sbjct: 9131 EGYDEGEEEWEEAYQEREVIQV------------QKEVYEESHERKVPAKVPEKKAPP-- 9176
Query: 491 DGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 539
K I K V +K+E+ EE+ V KV +V+ + ++ +++
Sbjct: 9177 --PPKVIKKPVI--EKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRT 9221
Score = 52.8 bits (125), Expect = 8e-07
Identities = 92/360 (25%), Positives = 132/360 (36%), Gaps = 92/360 (25%)
Query: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSP----VKATAPEVKEEEGEKEEEEGQEEEEEED 164
K+ KK A+ KE P EE+ K P + A APE+ + + EE + ++
Sbjct: 8991 KDAKKVVAKPKEMTPR---EEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKK- 9046
Query: 165 EGAKSDQAEEGGSEKEGSSEK------------------------------------EEG 188
E EKE EK EE
Sbjct: 9047 ---------EVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEP 9097
Query: 189 EQEEGETEAEA-------------EGEEAEAKEE--KKVEEKSEEVATKEELVADAKVEK 233
+++ E + EA EG+E +EE + EE+ EE + E++ K
Sbjct: 9098 DEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVY 9157
Query: 234 PEKAKSPVPKSPVEEKGKSP--VPKSPVEEK--------GKSPVPKSPVEEKGKSPVPKS 283
E + VP E+K P V K PV EK + V + V E K VP+
Sbjct: 9158 EESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQK 9217
Query: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPV--EEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 341
P ++PV + +E K + K V EE A + E + KE EEK
Sbjct: 9218 P----SRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEK 9273
Query: 342 ----VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE 397
+ K+ E P VPE E P EE V I K V+ K + KP+ +EK+
Sbjct: 9274 IHVAISKRVEPPPKVPE--LPEKPAPEEVAP--VPIPKKVEPPAPKVPEVPKKPVPEEKK 9329
Score = 49.3 bits (116), Expect = 9e-06
Identities = 58/252 (23%), Positives = 96/252 (38%), Gaps = 25/252 (9%)
Query: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEV---A 131
K E+ + V + KS+M E +++ + E K A EEK E ++ ++
Sbjct: 32500 KKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTL 32559
Query: 132 AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 191
A + K + V E E + + E + Q + + ++ K + E
Sbjct: 32560 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFE 32619
Query: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVAT-KEELVADAKVEKPEKAKSPVPKSPVEEKG 250
+A EG + E + ++++E T ++ V + V P + KSP P+ E
Sbjct: 32620 ISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAV 32679
Query: 251 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP 310
KSP ++ KSP P P K SP P +P E+ PV P
Sbjct: 32680 KSP-------KRVKSPEPSHP---KAVSPTETKP-----------TPTEKVQHLPVSAPP 32718
Query: 311 VEEAKSKAEVGK 322
KAE K
Sbjct: 32719 KITQFLKAEASK 32730
Score = 43.9 bits (102), Expect = 4e-04
Identities = 88/384 (22%), Positives = 146/384 (38%), Gaps = 46/384 (11%)
Query: 139 ATAPEVK---EEEG---EKEEEEGQEEEEEEDEGAKSDQAEEG--GSEKEGSSEKEEGEQ 190
AT PEV ++EG E E +E ++++ EG G +++ + G
Sbjct: 336 ATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGAAGAA 395
Query: 191 EEGETEAE--AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP--EKAKSPVPKSPV 246
A AE AKE K+ +KS VAT V A+V +P + ++
Sbjct: 396 ASVSASASYAAEAVATGAKEVKQDADKSAAVATVVAAVDMARVREPVISAVEQTAQRTTT 455
Query: 247 EEKGKSPVPKSPVEEKGKSPVPKSPV-EEKGKSPVPKSPVEEKGKSPVSKSPV------E 299
P + +E K+ V K V +K K KS +E + + V +
Sbjct: 456 TAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQIRK 515
Query: 300 EKAKSPVPKSPVEEAKSK-AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
E K+ VPK + AK+K E E+ +++K+V + ++ E V K
Sbjct: 516 ETEKTFVPKVVISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAASMVVVATAKST 575
Query: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGK----------PLQQEKEKEKAGGEGGS- 407
+ A E T + + EK KE K P +E++ G EG +
Sbjct: 576 KLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQDLVSRGREGITT 635
Query: 408 -------EEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDL 460
+E K A+ + IAV ++E T+E + R+E+ V +D+
Sbjct: 636 KREQVQITQEKMRKEAEKTALSTIAVATAKAKEQETILRTRETMATRQEQIQVTHGKVDV 695
Query: 461 SPADEKKGGDKSEEKVVVTKTVEK 484
G K+E V V++
Sbjct: 696 --------GKKAEAVATVVAAVDQ 711
Score = 43.9 bits (102), Expect = 4e-04
Identities = 71/284 (25%), Positives = 108/284 (38%), Gaps = 44/284 (15%)
Query: 60 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAI-TEELAVSMKEEKKEAAEE 118
I+KP+ PK E++IE+ K++ A +E +K K+ E
Sbjct: 10855 IKKPEAPPPK----EPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPE 10910
Query: 119 KEEEPEAEEE---EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175
K + PE E +V + V+ PE K E E+ + + E+E K + +
Sbjct: 10911 KPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLE 10970
Query: 176 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE--KSEEVATKEELVADAKVEK 233
+K E + E E E K E+K+ E K E+ L A K
Sbjct: 10971 KVKKPAVPEPPPPKPVE---EVEVP---TVTKRERKIPEPTKVPEIKPAIPLPAPEPKPK 11024
Query: 234 PEKAKSPVPKSPVEEK-------------GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 280
PE + PVE + GK K+P EE K PK P+ KG
Sbjct: 11025 PEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAK---PKGPI--KGVPKK 11079
Query: 281 PKSPVEEK---------GKSPVSKSPVEEKAKSPVPKSPVEEAK 315
SP+E + G+ P ++P + K+ VP V+E K
Sbjct: 11080 TPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKA-VPLKFVKEIK 11122
Score = 41.6 bits (96), Expect = 0.002
Identities = 77/330 (23%), Positives = 126/330 (38%), Gaps = 38/330 (11%)
Query: 202 EEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP-KSPVE 260
++A K+ KKV K +E+ +EE+V K P P + + K + S E
Sbjct: 8986 KKAVKKDAKKVVAKPKEMTPREEIV----------KKPPPPTTLIPAKAPEIIDVSSKAE 9035
Query: 261 EKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEV 320
E + + +K K V E+K K E + P + VE E
Sbjct: 9036 EVKIMTITRKKEVQKEKEAV----YEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQ 9091
Query: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVH 380
E+ +E+ +E+K K+E E+ EE ++ E + E E + +
Sbjct: 9092 PYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQ 9151
Query: 381 LEKETKEEG---KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
++KE EE K + EK+ ++ +K K SR+ + EE
Sbjct: 9152 VQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRME----------EEKV 9201
Query: 438 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYI 497
Q TK E K +V +P E + E KV T + + SE +
Sbjct: 9202 QVTKVP----EVSKKIVPQKPSRTPVQE----EVIEVKVPAVHTKKMVISEEKMFFASHT 9253
Query: 498 TKSVTVTQKVEEHEETFEEKL--VSTKKVE 525
+ V+VT + E EEK+ +K+VE
Sbjct: 9254 EEEVSVTVPEVQKEIVTEEKIHVAISKRVE 9283
Score = 40.0 bits (92), Expect = 0.005
Identities = 70/370 (18%), Positives = 136/370 (36%), Gaps = 52/370 (14%)
Query: 58 SKIQKPKVEAPKLKVQHK-----FVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 112
+++++P + A + Q ++ E+ + E EK+ + + + A + +K
Sbjct: 436 ARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRT 495
Query: 113 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEV-------KEEEGEKEEEEGQEEEEEEDE 165
KE K+E+ E++ +K K P+V KE+E EE +++++ E
Sbjct: 496 KEVITTKQEQMHVTHEQI--RKETEKTFVPKVVISAAKAKEQETRISEEITKKQKQVTQE 553
Query: 166 GAKSDQAEEGGS------EKEGSSEKEEGEQEEGETEAEAEGEEAE-------------- 205
+ + S K E G QEE T+ + E
Sbjct: 554 AIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKV 613
Query: 206 ------AKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV 259
KE+ V E + TK E V + EK + K+ + +
Sbjct: 614 IVATPKVKEQDLVSRGREGITTKREQVQITQ----EKMRKEAEKTALSTIAVATAKAKEQ 669
Query: 260 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 319
E ++ + +E+ + K V +K ++ + ++A+ P+ P +S A
Sbjct: 670 ETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVREPREPGHLEESYA- 728
Query: 320 VGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE-KKKAESPVKEEAVAEV-VTITKSV 377
Q+ E KE KV + ++P P KA P +A +E + T
Sbjct: 729 -----QQTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSETHIKTTDQK 783
Query: 378 KVHLEKETKE 387
+H+ + K+
Sbjct: 784 GMHISSQIKK 793
Score = 34.3 bits (77), Expect = 0.30
Identities = 43/165 (26%), Positives = 72/165 (43%), Gaps = 22/165 (13%)
Query: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
E K + P+ +E K K E+ +Q+E+ ++ AP+ E K E +K
Sbjct: 1909 EVKVTAENPEGVIEH-KVKLEI---QQREDFRSVLRRAPEPRPEFHVHEPGKLQFEVQKV 1964
Query: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 418
+ PV EVV + ++ ++ EK +E ++ + K K E G E + K
Sbjct: 1965 DRPVDTTETKEVVKLKRAERITHEKVPEES----EELRSKFKRRTEEGYYEAITAVELK- 2019
Query: 419 SRKEDIAVNGEVEGKEEVEQETKE------KGSGREEEKGVVTNG 457
SRK+D E EE+ ++TK+ K EE+K + G
Sbjct: 2020 SRKKD-------ESYEELLRKTKDELLHWTKELTEEEKKALAEEG 2057
Score = 31.6 bits (70), Expect = 1.9
Identities = 86/400 (21%), Positives = 156/400 (39%), Gaps = 85/400 (21%)
Query: 54 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK 113
+T + P+V++P+ +V K E + +V+ + +A VS E K
Sbjct: 32655 VTEKAVTSPPRVKSPEPRV--KSPEAVKSPKRVKSPEPSHPKA---------VSPTETKP 32703
Query: 114 EAAEEKEEEP-----------EAE-EEEVAAKKSPVKATAPEVKE----EEGEKEEEEGQ 157
E+ + P +AE +E+A V+++ KE ++G+K +E G
Sbjct: 32704 TPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGH 32763
Query: 158 EEEEEEDEGA---------KSDQAE-------EGGSEKE-----GSSEKEEGEQEEGETE 196
+ +G +SDQ E EGG+ K G + K E+ +E
Sbjct: 32764 FQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISE 32823
Query: 197 AEAEGEEA-EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP 255
+ ++ E+ +K E K+ E + + ++ + + S V K V+ G+ P P
Sbjct: 32824 TKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDS-VAKFAVKATGE-PRP 32881
Query: 256 KSPVEEKGKSPVPKSPV---EEKGKS--PVPKSPVEEKG-----------------KSPV 293
+ + GK+ E+KG + K+ + G K +
Sbjct: 32882 TAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941
Query: 294 SKSPVEEKAKSPVPKS----PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349
E K K+ P ++A + E+ + + EE K + EA +EK+ KEE
Sbjct: 32942 KAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIK-MSEAKSQEKLALKEEAS 33000
Query: 350 K---DVPEKKKAESPVKEEAVAEVVTIT----KSVKVHLE 382
K KK A + +++ V E +T T + V+ H E
Sbjct: 33001 KVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAE 33040
Score = 31.2 bits (69), Expect = 2.5
Identities = 60/269 (22%), Positives = 104/269 (38%), Gaps = 44/269 (16%)
Query: 297 PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKE------EKVEKKEEKPK 350
P +E+ + K+ V + A+ K ++ + KEV +E E++ K+ EK
Sbjct: 462 PAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEVITTKQEQMHVTHEQIRKETEK-T 520
Query: 351 DVP------------------EKKKAESPVKEEAVAEVVTITKS--VKVHLEKETKEEGK 390
VP E K + V +EA+ + IT + V V K TK E
Sbjct: 521 FVPKVVISAAKAKEQETRISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETV 580
Query: 391 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
P QE+ + S E+ + K + I +V+ ++ V + GRE
Sbjct: 581 PGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIVATPKVKEQDLVSR-------GRE-- 631
Query: 451 KGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEH 510
G+ T + EK + E + T+ T++ + T T+ T+ +E
Sbjct: 632 -GITTKREQVQITQEKM---RKEAEKTALSTIAVATAKAKEQETILRTRETMATR--QEQ 685
Query: 511 EETFEEKLVSTKKVEKVTSHAIVKEVTQS 539
+ K+ KK E V + +V V Q+
Sbjct: 686 IQVTHGKVDVGKKAEAVAT--VVAAVDQA 712
Score = 30.8 bits (68), Expect = 3.3
Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 9/115 (7%)
Query: 234 PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS-- 291
P ++K + K+ ++ G+ P+ K + V +P E G + +E+K K
Sbjct: 18381 PTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHST 18440
Query: 292 ---PVSKSPVEE---KAKSPVPKSPVE-EAKSKAEVGKGEQKEEEEKEVKEAPKE 339
PV+KS + E K ++ +P + K++ E+G GE V + P E
Sbjct: 18441 RWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIE 18495
Score = 30.4 bits (67), Expect = 4.3
Identities = 26/91 (28%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
Query: 69 KLKVQHKFVEEII--EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAE 126
K VQ + ++ + EE K+ + KS+ + AL ++ +S +E KK AA E+ E
Sbjct: 32965 KAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLIS-EEVKKSAATSLEKSIVHE 33023
Query: 127 EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 157
E ++ S T E+K + EGQ
Sbjct: 33024 EITKTSQASEEVRTHAEIKAFSTQMSINEGQ 33054
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 105 bits (261), Expect = 1e-22
Identities = 106/406 (26%), Positives = 176/406 (43%), Gaps = 59/406 (14%)
Query: 64 KVEAPKLKVQHKFVEEIIE-----ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
K ++ + + Q KF EE ++ +T V E E TA ++ E K+ ++
Sbjct: 264 KDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD-----NEGDKKKKDK 318
Query: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
K+++ E EE+E KK P KAT ++E + +EEE +++ EEE+ + ++ E
Sbjct: 319 KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELE----A 374
Query: 179 KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE----LVADAKVEKP 234
K E+ E E+ E + + E E +E KE K + + E + E L+ VE P
Sbjct: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP 434
Query: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS---------PVPKSPVEEKGKSPVPKSPV 285
K P + E+K + +P+ +E K S V + V EK ++P P P
Sbjct: 435 SKDSLPKKRPIYEDKKRKKIPQQ-LESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
Query: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 345
EE+ E A S VE K EV + ++EEEE+E +EE+ E+
Sbjct: 494 EEEDTEDAGLDDWEAMA-SDEETEKVEGNKVHIEVKENPEEEEEEEE-----EEEEDEES 547
Query: 346 EEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEG 405
EE+ ++ E + +E ++E V+ + K+ GK L ++ KE +
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVS---------------DEKDSGKTLDKKPSKEMS---S 589
Query: 406 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
SE + D K R D + K +E+ E EK
Sbjct: 590 DSEYDSDDDRTKEERAYD-------KAKRRIEKRRLEHSKNVNTEK 628
Score = 90.5 bits (223), Expect = 3e-18
Identities = 126/514 (24%), Positives = 223/514 (43%), Gaps = 67/514 (13%)
Query: 61 QKPKVEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTAI-----TEELAVSMKEE 111
QK K + K K + F E+ I EE +E + + + A+ EE S ++
Sbjct: 38 QKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKK 97
Query: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
KK +K+ + + EE+ K S K TA P+V+ G ++++ + ++ A+
Sbjct: 98 KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKS 157
Query: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS-------------- 216
+ GSE++ + K+ E+ + E+ E E + +K ++K+
Sbjct: 158 NKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNE 217
Query: 217 -EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVE-EKGKSPVPK-SPVE 273
++ + K + VA K EK E+ + K EEK K K E E GK K +
Sbjct: 218 DDDASFKIKTVAQKKAEKKERER----KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273
Query: 274 EKGKSPVPKSPVE-EKGKSPVSKSPVEEKAKSPVPKSPVEEA--KSKAEVGKGEQKEEEE 330
K + KS V + G P S EEKA++P E K K + K +KEE+E
Sbjct: 274 RKFEEETVKSKVTVDTGVIPAS----EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE 329
Query: 331 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV--AEVVTITKSVKVHLEKETKEE 388
KE K+ P + V+ +E + E+++ + +EE + E + + + LE+E +E
Sbjct: 330 KEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRER 389
Query: 389 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI----AVNGEVEGKEE------VEQ 438
K Q+EKE+++ + G S + A+ + + A EV K+ + +
Sbjct: 390 KK--QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447
Query: 439 ETKEKGSGREEEKGVVTNGLDLSPADE--KKG-GDKSEEKVVVTKTVEKITSEGG----- 490
+ K K ++ E V+ ++L A E ++G +K E V E+ T + G
Sbjct: 448 DKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507
Query: 491 ----DGATKYITKS---VTVTQKVEEHEETFEEK 517
D T+ + + + V + EE EE EE+
Sbjct: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE 541
Score = 89.7 bits (221), Expect = 6e-18
Identities = 111/516 (21%), Positives = 217/516 (42%), Gaps = 57/516 (11%)
Query: 57 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK--E 114
S K KPKVE ++ ++ K + +KS + + E+ + +KE +
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINS 182
Query: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
+ E +E E + KK+ P + E G ++++ + + + A+ + E
Sbjct: 183 SGESGDESDEFLQSRKGQKKNQKNKPGPNI--ESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
++E + ++ E+EE ET G++ ++K+ K+ + K EE K ++ D V
Sbjct: 241 KKRDEEKAKLRKLKEKEELET-----GKKDQSKQ-KESQRKFEEETVKSKVTVDTGVIPA 294
Query: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE-----KG 289
+ K+ P + ++ K ++KG+ K ++KG S ++E K
Sbjct: 295 SEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE-EKEKEKKKGPSKATVKAMQEALAKLKE 353
Query: 290 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE--------- 340
+ K EE+ K + + + E K E+K+++EKE KE K+E
Sbjct: 354 EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQR 413
Query: 341 ------------------KVEKKEEKPKDVP-----EKKKAESPVKEEAVAEVVTITKSV 377
+V K+ PK P ++KK ++ + V+E + + +V
Sbjct: 414 EARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAV 473
Query: 378 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE-EGSDKGAKGSRKEDIAVNGEV-----E 431
+V + ++E P E E+E+ + G ++ E + + E V+ EV E
Sbjct: 474 EVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEE 533
Query: 432 GKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491
+EE E+E +++ S EEE+ + G + DEK +K K + K ++++S+
Sbjct: 534 EEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEY 593
Query: 492 GATKYITKSVTVTQKVE---EHEETFEEKLVSTKKV 524
+ TK K + E K V+T+K+
Sbjct: 594 DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKL 629
Score = 85.1 bits (209), Expect = 1e-16
Identities = 125/534 (23%), Positives = 222/534 (41%), Gaps = 72/534 (13%)
Query: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSM----KEEKKEAAEEKE-----E 121
K ++K + ++ ++ +E+E A A +E S KE+KK+ +E + E
Sbjct: 4 KQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELE 63
Query: 122 EPEAEEEEVAAKKSPVKATAPEVKEEE------------GEKEEEEGQEEEEEEDEGAKS 169
E E + + A + V E EEE G+K+ + + EE ED+ +KS
Sbjct: 64 ELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKS 123
Query: 170 DQAEE------GGSEKEGSSEK--EEGEQEEGETEAEAEGEEAEAKEEKKVEEKS----- 216
+ + GS+ + K ++ + + ++ + +G E + KK++E+S
Sbjct: 124 KKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
Query: 217 -EEVATKEELVADAKVEKPEKAKSPVP--KSPVEEKGKSPVPKSPVEEKG--KSPVPKSP 271
E +E + K +K + P P +S E+ S K+ ++K K K
Sbjct: 184 GESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKR 243
Query: 272 VEEKGKSPVPKSPVE-EKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG-----EQ 325
EEK K K E E GK SK ++ K E KSK V G E+
Sbjct: 244 DEEKAKLRKLKEKEELETGKKDQSKQKESQR------KFEEETVKSKVTVDTGVIPASEE 297
Query: 326 KEE-----EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVH 380
K E E+ + K++K +KK EK + EKKK S +A+ E + K +
Sbjct: 298 KAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER 357
Query: 381 LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 440
++E +E K L++ + K K E+ K + RKE + G++ K + E
Sbjct: 358 QKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA 417
Query: 441 KEKGSGR-EEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD--GATKYI 497
+ + + + + +GV D P DK +K + + K SE + A + +
Sbjct: 418 RAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK-IPQQLESKEVSESMELCAAVEVM 476
Query: 498 TKSVTVTQKV------EEHEETFE------EKLVSTKKVEKVTSHAIVKEVTQS 539
+ V ++ EE E+T + E + S ++ EKV + + EV ++
Sbjct: 477 EQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKEN 530
Score = 73.9 bits (180), Expect = 3e-13
Identities = 104/476 (21%), Positives = 206/476 (43%), Gaps = 54/476 (11%)
Query: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED--- 164
M +++K +E+ ++ + A + A E ++ +G+K++E+ +++ +E+D
Sbjct: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
Query: 165 ---------EGAKSDQ-------AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 208
+G K+D+ E E +K++G++ + ++ + + EE E K+
Sbjct: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
Query: 209 EKKVEEKSEEVATKEELVADAKVEK-PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 267
K + +V D K P+KAK KS + G E+ K
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG-----SEEDEDNSKKIK 175
Query: 268 PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE----------AKSK 317
+S + G+S +E +S + ++ P +S E+ A+ K
Sbjct: 176 ERSRINSSGES---GDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKK 232
Query: 318 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
AE + E+K+ +E++ K +EK E+ E KD ++K+++ +EE V VT+ V
Sbjct: 233 AEKKERERKKRDEEKAKLRKLKEK-EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
Query: 378 ------KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE----EGSDKGAKGSRKEDIAVN 427
K +++ + +++K+K+K GE +E +G K + +E +A
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL 351
Query: 428 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKIT- 486
E E +++ E+E + K E K L+ + KK +K E K + K + +T
Sbjct: 352 KEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEK-ERKERLKKEGKLLTK 410
Query: 487 SEGGDGATKYITKSVTVTQKVE-EHEETFEEK--LVSTKKVEKVTSHAIVKEVTQS 539
S+ A T + Q VE +++ +K + KK +K+ KEV++S
Sbjct: 411 SQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466
Score = 68.6 bits (166), Expect = 1e-11
Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 18/211 (8%)
Query: 54 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK 113
+ + SK PK + K + + +E +V + ME E V KEE
Sbjct: 431 VEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES---MELCAAVEVMEQGVPEKEETP 487
Query: 114 EAAEEKEEEPEAEE-----EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAK 168
E +EEE + E +A+ + K +V E E EEE +EEEEEE+
Sbjct: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEE---- 543
Query: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-GEEAEAKEEKKV----EEKSEEVATKE 223
D+ E E+EG SE EG++E+ + E + G+ + K K++ E S++ TKE
Sbjct: 544 -DEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
Query: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPV 254
E D + EK + K+ EK ++P+
Sbjct: 603 ERAYDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 102 bits (254), Expect = 9e-22
Identities = 130/499 (26%), Positives = 221/499 (44%), Gaps = 58/499 (11%)
Query: 68 PKLKVQHKFVEEIIEETKVED-EKSEMEEALTAITEELAVSMKEEKKEAAEEKE----EE 122
P V+ + EE E TKV EK E+ + + +K E K + EKE EE
Sbjct: 553 PSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEE 612
Query: 123 PEAEEEEVAAKKS----PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
P + EVA K++ P A VK+E K E++ +E+E+ + E AK + +
Sbjct: 613 PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKE-------D 665
Query: 179 KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKK-VEEKSEEVATKEELVADAKVEKPEKA 237
K ++E+ ++EE + E + E ++ E KE KK V++++ K+E+ + K E ++
Sbjct: 666 KTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
Query: 238 KSP---VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG--KSPVPKSPVEEKGKSP 292
K P + K P + K KS P S +K + PK P +E+ K V +EKGK
Sbjct: 726 KEPKKEIKKLPKDAK-KSSTPLSEA-KKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIK 783
Query: 293 VSKSPVEEKAKSPV--------PKSPVEEAKSKAEVGKGEQKEEEE----------KEVK 334
V K E KA V + V A A +G ++ E E K+ +
Sbjct: 784 VIKK--EGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE 841
Query: 335 EAPKEEKVEKKEEKPK----DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK---ETKE 387
E EE K+ KP+ + EK K PV+ + + +TK ++ T+
Sbjct: 842 ELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEG 901
Query: 388 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGR 447
EG+ Q +E E +G + E + +G+ E+ + G+ E K E E+ + + G
Sbjct: 902 EGECEQTPEELEPVEKQGVDDIEKFED--EGAGFEESSETGDYEEKAETEEAEEPEEDGE 959
Query: 448 EEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 507
E V + SP ++++ K+E + + E + S G D A + + +++ +
Sbjct: 960 EH---VCVSASKHSPTEDEESA-KAEADAYIREKRESVAS-GDDRAEEDMDEAIEKGEAE 1014
Query: 508 EEHEETFEEKLVSTKKVEK 526
+ EE EE + E+
Sbjct: 1015 QSEEEADEEDKAEDAREEE 1033
Score = 79.7 bits (195), Expect = 6e-15
Identities = 125/550 (22%), Positives = 215/550 (39%), Gaps = 83/550 (15%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKV--EDEKSEMEEALTAITE-ELAVSMKEEKKEA 115
K + + +A +K + + + +ETKV ED+K E E+ + + E +K+E+K
Sbjct: 617 KAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPK 676
Query: 116 AEE--KEEEPEAEEEEVAAKKSPVKATAP--EVKEEEGEKEEEEGQEEEEE--------- 162
EE KE + E ++EE K VK P EVK+E ++E++E ++EE+E
Sbjct: 677 KEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP 736
Query: 163 -------------------------EDEGAKSDQAEEGGSEKEGSSE--KEEGEQEEGET 195
++E K D G +++G + K+EG+ E
Sbjct: 737 KDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVA 796
Query: 196 EAEAEGEEAEA----------KEEKKVEEKSEEVATKEELVAD---AKVEKPEKAKSPVP 242
A G A K++E + +++ E+L D K E+ + K P
Sbjct: 797 AAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP 856
Query: 243 KSPV---EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
+ + EEK K P + + V K P E + E ++P PVE
Sbjct: 857 QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVE 916
Query: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK-----VEKKEEKPKDVPE 354
++ + K E A + G+ +E+ E E E P+E+ V + P + E
Sbjct: 917 KQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEE 976
Query: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
KAE+ E V E E+G+ Q E+E ++ + EE +
Sbjct: 977 SAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEP 1036
Query: 415 GAKGSRKEDIAV---NGEVEGKEE----VEQETKEKGS---GREEEKGVVTNGL------ 458
+ +AV E G EE + TK+ G+ GRE + L
Sbjct: 1037 EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSES 1096
Query: 459 DLSPADEKKGGDKSEEKVVV---TKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFE 515
+ + +DE+ D+ EE T++ +I+SE + V + E E+
Sbjct: 1097 EATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPS 1156
Query: 516 EKLVSTKKVE 525
++ V+ K E
Sbjct: 1157 QEFVNITKYE 1166
Score = 75.1 bits (183), Expect = 2e-13
Identities = 84/276 (30%), Positives = 125/276 (45%), Gaps = 36/276 (13%)
Query: 191 EEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKG 250
++ + + A+ E+ K + KS +KEE KV EK PK VE K
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKP----PK--VESKE 584
Query: 251 KSPVPKS-PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 309
K V K P++ + K V + V K + K+ V EK + V +EK K
Sbjct: 585 KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKV 644
Query: 310 PVEEAKS-----KAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKE 364
E+ K K EV K E K +KE E PK+E+V+K+ +K EKK+ + VK+
Sbjct: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKE--EKPKKEEVKKEVKKEIKKEEKKEPKKEVKK 702
Query: 365 EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS----- 419
E T K VK ++KE K+E K ++EKE +K E + K AK S
Sbjct: 703 E------TPPKEVKKEVKKEEKKEVK--KEEKEPKK-------EIKKLPKDAKKSSTPLS 747
Query: 420 -RKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVV 454
K+ A+ +V KEE + +G+ +EKG +
Sbjct: 748 EAKKPAALKPKVPKKEE-SVKKDSVAAGKPKEKGKI 782
Score = 57.8 bits (138), Expect = 3e-08
Identities = 58/245 (23%), Positives = 104/245 (42%), Gaps = 17/245 (6%)
Query: 161 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 220
EE E ++ + GG+ K++G Q + ET + E A ++ + V ++EE
Sbjct: 2113 EEPTEESEKPLTQSGGAPPPPGG-KQQGRQCD-ETPPTSVSESAPSQTDSDVPPETEECP 2170
Query: 221 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 280
+ + ADA ++ +++++ V K P P +PV+++ SP P+ P
Sbjct: 2171 S---ITADANIDSEDESETIPTDKTVTYKHMDP-PPAPVQDR--SPSPRHPDVSMVD--- 2221
Query: 281 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE 340
P++ E+ K ++EK K+ K P + KS + V K + K K + +PK
Sbjct: 2222 PEALAIEQNLGKALKKDLKEKTKT---KKPGTKTKSSSPVKKSDGKS---KPLAASPKPA 2275
Query: 341 KVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 400
+++ +K V KK ES K + + +KETK + K
Sbjct: 2276 GLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTA 2335
Query: 401 AGGEG 405
G G
Sbjct: 2336 TAGPG 2340
Score = 48.9 bits (115), Expect = 1e-05
Identities = 99/495 (20%), Positives = 169/495 (34%), Gaps = 86/495 (17%)
Query: 54 ITISSKIQKPKVEAPKLKVQ-HKFVEEIIEETKVEDEKSE--MEEALTAITEELAVSMKE 110
+ +S+ P + K + ++ E E D+++E M+EA+ E + +
Sbjct: 962 VCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEAD 1021
Query: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---------EEGQEEEE 161
E+ +A + +EEE E E+ E + V A + E G +E+ + G +
Sbjct: 1022 EEDKAEDAREEEYEPEKMEA---EDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPG 1078
Query: 162 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 221
E + D+ GGSE E ++ EE +++ E G E +E++T
Sbjct: 1079 REPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMST 1138
Query: 222 KEELVADA----KVEKPEKAKSPVPK------SPVEEKGKSPVPKSPVEEKGKSPV---- 267
++++D + E P + + K S K P + E K+
Sbjct: 1139 PRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGK 1198
Query: 268 -----------PKSPVEEKGKSPVPK-------------------SPVEEKGKSPVSKSP 297
P S E+K + S V + SP
Sbjct: 1199 DYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPS 1258
Query: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKK 357
+ SP+ K+P+ E + E K E EV E E EE PE K
Sbjct: 1259 LSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCAS-PEDKT 1317
Query: 358 AESPVKEEAVA---------EVVTITKSVKVHLEKETKEEGKPLQQE----KEKEKAGGE 404
E ++V + T KS + E K P+ E K++ +
Sbjct: 1318 LEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASV 1377
Query: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ---ETKEKGSGREEEKGVVTNGLDLS 461
+E D + + + + G E + +K SGR E S
Sbjct: 1378 SPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAE----------S 1427
Query: 462 PADEKKGGDKSEEKV 476
P +EK G S ++V
Sbjct: 1428 PFEEKSGKQGSPDQV 1442
Score = 33.5 bits (75), Expect = 0.51
Identities = 40/209 (19%), Positives = 80/209 (38%), Gaps = 8/209 (3%)
Query: 46 PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA 105
P P+T S P P K Q + +E + E S+ + + TEE
Sbjct: 2115 PTEESEKPLTQSGGAPPP----PGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECP 2170
Query: 106 VSMKEEKKEAAEEKEEEPEAEE---EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 162
+ ++ +E E P + + + +PV+ +P + + + E E+
Sbjct: 2171 SITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQN 2230
Query: 163 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
+ K D E+ ++K G+ K ++ + +++ + K+ +K VA+
Sbjct: 2231 LGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASP 2290
Query: 223 EELVADAKVEKPEKAKSPVPKSPVEEKGK 251
++ + K KP V + EEK K
Sbjct: 2291 KKKESVEKAAKPTTTPE-VKAARGEEKDK 2318
Score = 33.1 bits (74), Expect = 0.66
Identities = 64/297 (21%), Positives = 102/297 (34%), Gaps = 41/297 (13%)
Query: 68 PKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEE 127
PK ++ F+ E +E +E E +T+ K+ + +E P
Sbjct: 2093 PKTELSPSFINPNPLEWFASEEPTEESEK--PLTQSGGAPPPPGGKQQGRQCDETPPTSV 2150
Query: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187
E A ++ PE EE + + E+E E +D+ + ++
Sbjct: 2151 SESAPSQTD-SDVPPET--EECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQD 2207
Query: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP---EKAKSPVPKS 244
+ EA A E+ + A K++L K +KP K+ SPV KS
Sbjct: 2208 RSPSPRHPDVSMVDPEALAIEQNLGK------ALKKDLKEKTKTKKPGTKTKSSSPVKKS 2261
Query: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 304
GKS + SP P E K + SP K VE+ AK
Sbjct: 2262 ----DGKS-------KPLAASPKPAGLKESSDK--------VSRVASPKKKESVEKAAK- 2301
Query: 305 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
P + KA +GE+K++E K A + + P K + P
Sbjct: 2302 -----PTTTPEVKA--ARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
Score = 32.3 bits (72), Expect = 1.1
Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 33/311 (10%)
Query: 86 VEDEKSEMEEALTAITEELAVSMKE--EKKEAAEEKEEEPEAEE--EEVAAKK------S 135
V D +S +E+ L+ + + + E +A++K AE EE + K+ S
Sbjct: 1384 VPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVS 1443
Query: 136 PVK---ATAPEVKEEEGEK------EEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKE 186
PV +T+ ++EG+ +E+ GQE++ ++ E S A K G
Sbjct: 1444 PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPT 1503
Query: 187 E------GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
+ G +E + +EG ++ E +E+ + E VA + P
Sbjct: 1504 QIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFP 1563
Query: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVSKSPVE 299
P + SP + + S V+ SP +E+ P+S SP +
Sbjct: 1564 EPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPD 1623
Query: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
K+ ++PV++ +S EQ + +E+P++ + D P
Sbjct: 1624 FSPKTAKSRTPVQDHRS-------EQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGV 1676
Query: 360 SPVKEEAVAEV 370
+ E EV
Sbjct: 1677 LHITENGPTEV 1687
Score = 30.4 bits (67), Expect = 4.3
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query: 101 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG-EKEEEEGQEE 159
++ LA S K + + +K + +++ + +K+ T PEVK G EK++E
Sbjct: 2265 SKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDKETKNAA 2324
Query: 160 EEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
+ AK+ A G ++ SS G
Sbjct: 2325 NASASKSAKTATAGPGTTKTTKSSAVPPG 2353
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 102 bits (253), Expect = 1e-21
Identities = 118/439 (26%), Positives = 194/439 (44%), Gaps = 67/439 (15%)
Query: 106 VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165
+S ++E+ + +E ++ E +E P ++++E K++ E QE+ E + +
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDE--------------PPLRKKEIHKDKTEKQEKPERKIQ 159
Query: 166 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE--AKEEKKVE--EKSEEVAT 221
+ + +E G EK EK E + E + E E + AKE+KK + EKSEE
Sbjct: 160 TKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTK 219
Query: 222 KE------ELVAD--AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 273
KE E V AKV++ +K P P E++ K S E+K + + ++
Sbjct: 220 KEVKGGKQEKVKQTAAKVKEVQK----TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMID 275
Query: 274 EKGKSPVPKSPVEEKGKSPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKE 332
+ + G+SP P+ E+A P P SP E K +GE+K+ E+K
Sbjct: 276 IFVHGDL------KPGQSPAIPPPLPTEQASRPTPASPALEEK------EGEKKKAEKKV 323
Query: 333 VKEAPKEEK--VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 390
E K+EK ++KK EK + +KK E V ++ EK KE+ K
Sbjct: 324 TSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEK--KEDSK 381
Query: 391 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
++ E E+ G+ ++E + AK +KE + +++ K K +EE
Sbjct: 382 KTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPS---------DKQVKAKTERAKEE 432
Query: 451 KGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITK-SVTVTQKVEE 509
G V + +K K EEK TKTVE+ + G T I K + K E+
Sbjct: 433 IGAV--------SIKKAVPGKKEEK--TTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEK 482
Query: 510 HEETFEEKLVSTKKVEKVT 528
+ +EK TKK EK++
Sbjct: 483 VPASLKEKEPETKKDEKMS 501
Score = 100 bits (248), Expect = 4e-21
Identities = 135/516 (26%), Positives = 214/516 (41%), Gaps = 50/516 (9%)
Query: 59 KIQKPKVEAPKLKVQHKFV--------EEIIEETKVEDEKSEMEEALTAITEELAVSMKE 110
K + K E P+ K+Q K E++ E+ K E + + E+ E KE
Sbjct: 145 KDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKE 204
Query: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
+KK EK EE + ++E K+ VK TA +VKE + + + ++E++E+ +K +
Sbjct: 205 QKKAKTAEKSEE-KTKKEVKGGKQEKVKQTAAKVKEVQ-KTPSKPKEKEDKEKAAVSKHE 262
Query: 171 QAEE------------GGSEKEGSS----EKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
Q ++ G K G S EQ T A EE E EKK E
Sbjct: 263 QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEG--EKKKAE 320
Query: 215 KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVPKSPVE 273
K TK++ D K + ++ V K +E GK S + V+ ++ K +
Sbjct: 321 KKVTSETKKKEKEDIKKKSEKETAIDVEK---KEPGKASETKQGTVKIAAQAAAKKDEKK 377
Query: 274 EKGKSPVPKSPVEE-KGKSPVSKSPVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEE 329
E K + VE+ KGK K E AKSP + V ++ K+K E K E
Sbjct: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVS 437
Query: 330 EKEVKEAPKEEKVEK--KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387
K+ KEEK K ++E K+ K + KE + + S+K E ETK+
Sbjct: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK-EKEPETKK 496
Query: 388 EGKPLQQEKE-KEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 446
+ K + KE K K G +EE + K K I+ ++ K+++ + K G
Sbjct: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH-KQDIVKPEKTVSHG 555
Query: 447 REEEK-----GVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSV 501
+ EEK VT P KK + E + K T +G T+ K
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
Query: 502 TVTQKVEEHE---ETFEEKLVSTKKVEKVTSHAIVK 534
+++K + + + E+ VST+K E + H + K
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRK-ESLQLHNVTK 650
Score = 89.7 bits (221), Expect = 6e-18
Identities = 103/411 (25%), Positives = 180/411 (43%), Gaps = 25/411 (6%)
Query: 42 SITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAIT 101
+I PL T + + + E K K + K + ETK K E E+
Sbjct: 289 AIPPPLPTEQASRPTPASPALEEKEGEKKKAEKK----VTSETK----KKEKEDIKKKSE 340
Query: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE-EEGEKEEEEGQEEE 160
+E A+ +++++ A E ++ + AAKK K + + K+ E E+ + + QE++
Sbjct: 341 KETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKK 400
Query: 161 EEEDEGAKSDQAEEG-GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEV 219
E+ E AKS + E S+K+ ++ E ++E G + + K+E+K + E+
Sbjct: 401 EKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIK---KAVPGKKEEKTTKTVEQE 457
Query: 220 ATKEELVADAKVEK-PEKAKSPVPKSPVEEKGKSPVPK--SPVEEKGKSPVPKSPVEEKG 276
KE+ + + K E K K P K K P K + + GK PK P +
Sbjct: 458 IRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK 517
Query: 277 KSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEA 336
K P+ ++++ K +S+ K P+ V K + +V K + EK K
Sbjct: 518 KEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
Query: 337 PKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG--KPLQQ 394
P +K E +E +P + K +P + +EV K EKE+KE+ K L++
Sbjct: 578 P-TKKAEHREREPPSIKTDKPKPTP---KGTSEVTESGKKKTEISEKESKEKADMKHLRE 633
Query: 395 EKEKEKAGGEGGSEEEGSDKGAKGSRK-EDIAVNGEV-EGKEEVEQETKEK 443
EK + ++K A+ S+ ED+ + + EG E+V TK+K
Sbjct: 634 EKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDV-SPTKQK 683
Score = 79.7 bits (195), Expect = 6e-15
Identities = 90/372 (24%), Positives = 151/372 (40%), Gaps = 69/372 (18%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEK------SEMEEALTAITEELAVSMKEEK 112
K +K K K + ++ +ET ++ EK SE ++ I + A E+K
Sbjct: 318 KAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKK 377
Query: 113 KEAAEEKE----EEP-----EAEEEEVAAKKSP-----------VKATAPEVKEEEGE-- 150
+++ + K+ E+P E +E+ V KSP VKA KEE G
Sbjct: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVS 437
Query: 151 -KEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE 209
K+ G++EE+ + + E+ G +KE + +E + A + +E E K++
Sbjct: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD 497
Query: 210 KKVEEKSEEVATKEELVADAKVEKPE-----------------------KAKSPVPKSPV 246
+K+ + +EV K + K EKPE K + V
Sbjct: 498 EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKP 557
Query: 247 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
EEK V +E+ K P P E + + P P ++ +P S V E K
Sbjct: 558 EEKVLKQVKAVTIEKTAK-PKPTKKAEHREREP-PSIKTDKPKPTPKGTSEVTESGKK-- 613
Query: 307 PKSPVEEAKSKAEVGKGEQKEEEEKEVKEA------PKEEKVEKKEEKPKDVPEKKKAE- 359
K+ + E +SK + +EE+ KE+ K EK + + +DVP KKA+
Sbjct: 614 -KTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
Query: 360 -----SPVKEEA 366
SP K+++
Sbjct: 673 GTEDVSPTKQKS 684
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/200 (26%), Positives = 87/200 (43%), Gaps = 21/200 (10%)
Query: 83 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142
ETK +++ S+ + + +L KEEK E +KE +P E+ K+ VK P
Sbjct: 493 ETKKDEKMSKAGKEVKPKPPQLQ-GKKEEKPEPQIKKEAKPAISEKVQIHKQDIVK---P 548
Query: 143 EVKEEEGEKEEEEGQEEE----EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 198
E G+ EE+ ++ + E+ + + +AE E + +G +E
Sbjct: 549 EKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVT 608
Query: 199 AEGEEAEAKEEKKVEEKS-------EEVATKEE---LVADAKVEKPEKAKSPVPKSPVEE 248
G++ EK+ +EK+ E+V+T++E L K EKP + V P +
Sbjct: 609 ESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASK 668
Query: 249 KGKSPVPK-SPVEEKGKSPV 267
K K SP K KSP+
Sbjct: 669 KAKEGTEDVSPT--KQKSPI 686
Score = 41.6 bits (96), Expect = 0.002
Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 45/196 (22%)
Query: 51 RPPITISSKIQKPKVEAPKLKVQH-KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMK 109
+P I+ +I K + P+ V H K E+++++ K A+T E K
Sbjct: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVK-------------AVTIEKTAKPK 577
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
KK AE +E EP + + + K P EV E G+K+ E ++E +E+
Sbjct: 578 PTKK--AEHREREPPSIKTD---KPKPTPKGTSEVTES-GKKKTEISEKESKEK------ 625
Query: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE----KKVEEKSEEVATKEEL 225
A+ +E S ++E Q T+AE ++ E+ KK +E +E+V+
Sbjct: 626 --ADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVS----- 678
Query: 226 VADAKVEKPEKAKSPV 241
P K KSP+
Sbjct: 679 --------PTKQKSPI 686
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 100 bits (250), Expect = 3e-21
Identities = 97/367 (26%), Positives = 157/367 (42%), Gaps = 70/367 (19%)
Query: 107 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 166
++KE KE +EKE+E KK AT PE + G+ +E+ +EE +DE
Sbjct: 1265 AVKENDKEKGKEKEKE----------KKEKTPATTPEARVL-GKDGKEKPKEERPNKDEK 1313
Query: 167 AKS--DQAEEGGSEKEGSSEKEEGEQEEGET-----EAEAEGEEAEAKEEKKVEEKSEEV 219
A+ ++ + EKE ++E+ + E+ +T E+++ E KE + + ++E+
Sbjct: 1314 ARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEM 1373
Query: 220 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 279
+KE + K KSPVP+S + E P E+ + + P S
Sbjct: 1374 KSKENVKGGEKTPVSGSLKSPVPRSDIPE---------PEREQKRRKIDTHP-SPSHSST 1423
Query: 280 VPKSPVEEKGKS----------PVSKSPVEEKAKSPVPKS--PVEEAKSKAEVGKGEQKE 327
V S +E K S P+SKS E K + KS E + K E + E+K
Sbjct: 1424 VKDSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKR 1483
Query: 328 EEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387
+ +E P + +KEE K K+ESP +
Sbjct: 1484 DHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCE------------------------ 1519
Query: 388 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG---KEEVEQETKEKG 444
P EK+KEK + +E+GSD K + + I+ G+ E KE++E++ K
Sbjct: 1520 --SPYPNEKDKEKNKSKSSGKEKGSD-SFKSEKMDKISSGGKKESRHDKEKIEKKEKRDS 1576
Query: 445 SGREEEK 451
SG +EEK
Sbjct: 1577 SGGKEEK 1583
Score = 65.1 bits (157), Expect = 2e-10
Identities = 77/306 (25%), Positives = 123/306 (40%), Gaps = 31/306 (10%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
+KPK E P + + +E ++ E EK + EE + V E K E+E
Sbjct: 1301 EKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQERERE 1360
Query: 121 EEPEAEEE---EVAAK-------KSPVKAT--APEVKEEEGEKEEEEGQEEEEEEDEGAK 168
+EP E + E+ +K K+PV + +P + + E E E+ + + + +
Sbjct: 1361 KEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSH 1420
Query: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVAD 228
S ++ E + SS K E E + K+ K E+S E K+E D
Sbjct: 1421 SSTVKDSLIELKESSAKLYINHTPPPLSKSKE-REMDKKDLDKSRERSREREKKDE--KD 1477
Query: 229 AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 288
K K + + + P + K EE G V K E +SP P +EK
Sbjct: 1478 RKERKRDHSNNDREVPP-------DLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEK 1530
Query: 289 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE---KVEKK 345
KS KS +EK +++ S GK E + ++EK K+ ++ K EKK
Sbjct: 1531 NKS---KSSGKEKGSDSFKSEKMDKISSG---GKKESRHDKEKIEKKEKRDSSGGKEEKK 1584
Query: 346 EEKPKD 351
K D
Sbjct: 1585 HHKSSD 1590
Score = 45.8 bits (107), Expect = 1e-04
Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 23/306 (7%)
Query: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
K +E S E K + V+ KA S PK V+E K +
Sbjct: 1218 KSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEK 1277
Query: 271 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE-QKEEE 329
E+K K+P GK K P EE+ +E K++ K + +KEE+
Sbjct: 1278 EKEKKEKTPATTPEARVLGKDGKEK-PKEERPNKDEKARETKERTPKSDKEKEKFKKEEK 1336
Query: 330 EKEVK----------EAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV 379
K+ K ++ +E + EK+ + +D+ ++ K++ VK E ++ S+K
Sbjct: 1337 AKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKG---GEKTPVSGSLKS 1393
Query: 380 HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA---VNGEVEG-KEE 435
+ + E ++E+++ K + K + KE A +N +
Sbjct: 1394 PVPRSDIPEP---EREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKS 1450
Query: 436 VEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGD-GAT 494
E+E +K + E+ D E+K + ++ V ++ E G G +
Sbjct: 1451 KEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVS 1510
Query: 495 KYITKS 500
K+ ++S
Sbjct: 1511 KHKSES 1516
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/167 (22%), Positives = 75/167 (44%), Gaps = 20/167 (11%)
Query: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
PP++ S + + K + K + + + E + +DEK E + +E
Sbjct: 1445 PPLSKSKEREMDKKDLDKSRERSR-------EREKKDEKDRKERKRDHSNND-----REV 1492
Query: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
+ + ++EE +SP ++ P K++E K + G+E+ + + K D+
Sbjct: 1493 PPDLTKRRKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDK 1552
Query: 172 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
GG +KE +KE+ E++E + + + KEEKK + S++
Sbjct: 1553 ISSGG-KKESRHDKEKIEKKE-------KRDSSGGKEEKKHHKSSDK 1591
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 100 bits (248), Expect = 4e-21
Identities = 112/513 (21%), Positives = 219/513 (42%), Gaps = 53/513 (10%)
Query: 57 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAA 116
+ K K K E + K + + E E VE++ +E +E ++ + EE K+
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
Query: 117 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGG 176
E ++ E E ++ +A A + E E+E + +++++ DE A+ + E+
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAA 302
Query: 177 SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKV---EK 233
+++ E EE E+ E + AE + +EEK+ E+ + + +E+ A+ + E+
Sbjct: 303 AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEE 362
Query: 234 PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 293
++A ++ EE+ K+ V + +++ K K ++ K K + +GK
Sbjct: 363 EKRAAEERQRARAEEEEKAKVEE---QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
Query: 294 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 353
K E+K ++ V K EE +K + + + +E++ KE K+EK++K +E ++V
Sbjct: 420 EKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479
Query: 354 ---EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGG---S 407
++KK + VK + E +T H K T E + GG
Sbjct: 480 SFMDRKKGFTEVKSQN-GEFMT-------HKLKHT---------ENTFSRPGGRASVDTK 522
Query: 408 EEEGSDKGAKGSRKEDI-AVNGEVEGKE---------EVEQETKEKGSGREEEKGVVTNG 457
E EG+ + G R E++ GE E +E E E +E REE + V+
Sbjct: 523 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 582
Query: 458 LDLSPADE-KKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVT-------------V 503
+E + + EEK + + +E+ +E + K ++
Sbjct: 583 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 642
Query: 504 TQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEV 536
+ K+EE E + + + V+ AIV ++
Sbjct: 643 SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKI 675
Score = 97.4 bits (241), Expect = 3e-20
Identities = 139/553 (25%), Positives = 238/553 (43%), Gaps = 61/553 (11%)
Query: 13 NVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKV 72
N ++ D E A +L EE R ++ P IT +S + P ++
Sbjct: 85 NTQVEGDDEAAFLERLARREERRQKRLQEALERQK-EFDPTITDAS------LSLPSRRM 137
Query: 73 QHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK---KEAAEEKEEEPE-AEEE 128
Q+ E ET ++EKSE + I E V+ +K ++A E K+E+ E EEE
Sbjct: 138 QNDTAEN---ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 194
Query: 129 EVAAKKSPVKATAPEVKEEEGEKEEEE---------GQ--EEEEEEDEGAKSDQAEEGGS 177
E K+ + EV EE E +E GQ EE +++E + E
Sbjct: 195 EEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHH 254
Query: 178 EKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 237
EK +KE E E EAE E E +A+++KK+ ++ + +E+ A + + +
Sbjct: 255 EKMEEEDKERAEAERARLEAE-ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEE 313
Query: 238 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297
+ + + EEK + + EE+ ++ + ++E+ K ++ E + K
Sbjct: 314 RERMRE---EEKRAAEERQRIKEEEKRAAEERQRIKEEEK----RAAEERQRIKEEEKRA 366
Query: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP--KEEKVEKKEEKPKDVPEK 355
EE+ ++ EE K+K E K ++ EE+K + K EKVE+K E K V EK
Sbjct: 367 AEERQRARAE----EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE-GKWVNEK 421
Query: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL---QQEKEKEKAGGEGGSEEEGS 412
K E + + AV + K KV ++E +E KP ++ K+++ + EE S
Sbjct: 422 KAQEDKL-QTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480
Query: 413 DKGAKGSRKEDIAVNGE-VEGKEEVEQETKEKGSGR-----EEEKGV--VTNGLDLSPAD 464
K E + NGE + K + + T + GR +E +G V G L
Sbjct: 481 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 540
Query: 465 EKKGGDKSEEKVVVTKTVEKITSEGGDGATKY--ITKSVTVTQKVEEHEETFEEKLVSTK 522
++G +SEE EK+ + + A + + K +KV E EE ++ + +
Sbjct: 541 RRRGETESEE-------FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR 593
Query: 523 KVEKVTSHAIVKE 535
K+ + +KE
Sbjct: 594 KLREEEEKRRLKE 606
Score = 90.1 bits (222), Expect = 5e-18
Identities = 107/479 (22%), Positives = 194/479 (40%), Gaps = 75/479 (15%)
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
E ++E +K EE E E +A +++ +E +E ++++EEE G +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRND-DDEEEAARERRRRARQERLRQKQEEESLGQVT 63
Query: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA--------EAKEEKKVEEKSEEVAT 221
DQ E + S EE + T+ E + E A E + +K+++E E
Sbjct: 64 DQVEVNA---QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Query: 222 KEELVADAKV-----------------EKPEKAKSPVPKSPVEEKGKSPVPKS------- 257
+ + DA + EK EK++S + +EE V KS
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET--ETVTKSYQKNDWR 178
Query: 258 PVEEKGKSPVPKSPVEEKG--KSPVPKSPVEEKGKSPVSKSPVEE--------KAKSPVP 307
EE K K EE+ + + ++ VE + ++S E + S P
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
Query: 308 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
K E + E+ E+ EEE+KE EA + ++ E+ K +KK A+ + EA
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Query: 368 AEVVTITKSVKVHLEKE-TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 426
+ + + E+E +EE K +E+++ K + +EE + K K
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER---QRIKEEEKRAAEE 355
Query: 427 NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKK--------GGDKSEEKVVV 478
++ +E+ E +++ EEEK V +EKK G+K E+K+
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEG 415
Query: 479 TKTVEK-----------ITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526
EK + +G + TK K +K++E + TF+++ + +K++K
Sbjct: 416 KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK----REKLQEDKPTFKKEEIKDEKIKK 470
Score = 50.8 bits (120), Expect = 3e-06
Identities = 65/273 (23%), Positives = 115/273 (42%), Gaps = 31/273 (11%)
Query: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 122
P+VEA K + + E + E K + +EA + E +K++++E + EEE
Sbjct: 528 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEE-----LKKKREERRKVLEEE 582
Query: 123 PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGS 182
+ ++E A +K + +KEE + E ++ ++ ++G D+ +GS
Sbjct: 583 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGS 642
Query: 183 SEK-EEGEQEEGETEAEAEGEEA--EAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
S K EE + ++ ++ G ++ +A K++ + E+ + E AK KP +
Sbjct: 643 SLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDL 702
Query: 240 PVPKSPVE------EKG---KSPVP-----------KSPVEEKGKSPVPKSPVEEKGKSP 279
PVP V EKG SP K V + + K+P + KSP
Sbjct: 703 PVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTP--DGNKSP 760
Query: 280 VPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
PK P + + SK + EK SP +
Sbjct: 761 APK-PSDLRPGDVSSKRNLWEKQSVDKVTSPTK 792
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 97.8 bits (242), Expect = 2e-20
Identities = 89/447 (19%), Positives = 205/447 (45%), Gaps = 42/447 (9%)
Query: 21 EIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEI 80
E+ +L+E E++ + L T + P+ ++++ + +++ Q V E
Sbjct: 15 ELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVRE---QEGQVREQEGQVRE- 70
Query: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEE---KKEAAEEKEEEPEAEEEE--VAAKKS 135
+E +V +++ ++ E + E+ ++E +++ + +E+E + E+E V ++
Sbjct: 71 -QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 136 PVKATAPEVKEEEGEKEEEEGQEEEEE----EDEGAKSDQ----AEEGGSEKEGSSEKEE 187
V+ +V+E+EG+ E+EGQ E+E E EG +Q E+ G +E + E
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 188 GEQEEGETEAE-AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV 246
E + GE E + E EE ++E++++++ E++ +EE + + + E+ + +
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 247 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
+K + + K + + + + E+ K E+ G+ EE+ +
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE 309
Query: 307 PKSPVEE---AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVK 363
+ +E + + ++GK E++ E+KE KE+ +++E+ + + +K E V+
Sbjct: 310 EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Query: 364 EEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKED 423
++ E+ K+E + +QE++ K E+ G K G +KE
Sbjct: 370 KQE---------------EQMRKQEEQMRKQEEQMRKQ-----EEQMGEQKEQMGEQKEQ 409
Query: 424 IAVNGEVEGKEEVEQETKEKGSGREEE 450
+ E G+++ + +E+ G ++E
Sbjct: 410 MREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 88.2 bits (217), Expect = 2e-17
Identities = 88/426 (20%), Positives = 200/426 (46%), Gaps = 18/426 (4%)
Query: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA-AEEKEE 121
P++ +LK ++ ++E ++ VE EKSE++ + + +L +E E+E
Sbjct: 2 PRITNEELKEKNAELQEELQ--LVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEG 59
Query: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE----EDEGAKSDQAEEGGS 177
+ +E +V ++ V+ +V+E+EG+ E+EGQ E+E E EG +Q E
Sbjct: 60 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVR 118
Query: 178 EKEGSSEKEEGE--QEEG---ETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVAD--A 229
E+EG ++EG+ ++EG E E + +E + +E++ +V E+ +V +E V +
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 230 KVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 289
+V + E E++G+ + + E+ + + K + + + E+ G
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ-EEQMQKQEEQMGEQEEQMRKQEEQMG 237
Query: 290 KSPVSKSPVEEKA-KSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 348
+ EE+ K EE + E EQ+E+ K+ ++ +EE+ ++EE+
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSE 408
++ E+ + + E ++ + + E+ +++ + +Q+++ K + G +
Sbjct: 298 MREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQ 357
Query: 409 EEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG 468
EE K + RK++ + + E + E++ +++ E+K + + E++
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 469 GDKSEE 474
G++ E+
Sbjct: 418 GEQKEQ 423
Score = 87.8 bits (216), Expect = 2e-17
Identities = 89/429 (20%), Positives = 198/429 (46%), Gaps = 24/429 (5%)
Query: 49 THRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSM 108
T + I + K K K+E K+ + +E +V +++ ++ E + E+
Sbjct: 25 TEKSEIQLHIKELKRKLETDKIPLP--------QEGQVREQEGQVREQEGQVREQ--EGQ 74
Query: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE----ED 164
E++ E+E + +E +V ++ V+ +V+E+EG+ E+EGQ E+E E
Sbjct: 75 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 134
Query: 165 EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA-EAEGEEAEAKEEKKVEEKSEEVATKE 223
EG +Q E E+EG ++EG+ E E + E EG+ E +E +V E+ +V +E
Sbjct: 135 EGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQE 191
Query: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283
+ + + + E+ + + +K + + + + + + E+ K
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
EE+ + + +E+ + + + K K + + EQ E+E++++E +EE++
Sbjct: 252 KQEEQMRKQEEQMREQEEQ---MREQEEQMLKQKEQTEQEEQTGEQEEQMRE--QEEQMR 306
Query: 344 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGG 403
++EE+ ++ E+ + + + ++ + + E+ K+E + +QE++ +K
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366
Query: 404 EGGSEEEGSDKGAKGSRKEDIAVNGEVEGK-EEVEQETKEKGSGREEEKGVVTNGLDLSP 462
+ +EE K + RK++ + + E E+ EQ ++K RE+E+ + +
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Query: 463 ADEKKGGDK 471
+E G K
Sbjct: 427 QEEHMGEQK 435
Score = 77.8 bits (190), Expect = 2e-14
Identities = 94/453 (20%), Positives = 209/453 (46%), Gaps = 65/453 (14%)
Query: 81 IEETKVEDEKSEMEEALTAIT---EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
I +++++ +E++E L + E+ + +KE K++ E ++ P +E +V ++ V
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKL--ETDKIPLPQEGQVREQEGQV 61
Query: 138 KATAPEVKEEEGEKEEEEGQEEEEE----EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 193
+ +V+E+EG+ E+EGQ E+E E EG +Q E E+EG ++EG+ E
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQ 120
Query: 194 ETEA-EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252
E + E EG+ E +E +V E+ +V +E V E++G+
Sbjct: 121 EGQVREQEGQVRE--QEGQVREQEGQVREQEGQVR-------------------EQEGQV 159
Query: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV-EEKGKSPVSKSPVEEKAKSPVPKSPV 311
+ V E ++G+ + V E++G+ + + E+
Sbjct: 160 REQEGQVRE------------QEGQVREQEGQVREQEGQVREQEGQMGEQ---------- 197
Query: 312 EEAKSKAEVGKGEQKEEEEKEVKE-APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV 370
E + E GEQ+E+ +K+ ++ +EE++ K+EE+ + E+ + + ++ ++
Sbjct: 198 EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM 257
Query: 371 VTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV 430
+ ++ E+ ++E + L+Q+++ E+ G EE+ ++ + +E+ E
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEE 317
Query: 431 EGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGG 490
+ +E+ EQ K++ E+++ + + +E+ G E++ + K E++ +
Sbjct: 318 QMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG----EQEEQMQKQEEQVRKQ-- 371
Query: 491 DGATKYITKSVTVTQKVEEHEETFEEKLVSTKK 523
+ + K +K EE EE++ K+
Sbjct: 372 ---EEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401
Score = 42.4 bits (98), Expect = 0.001
Identities = 57/288 (19%), Positives = 125/288 (43%), Gaps = 19/288 (6%)
Query: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV-EEAKSKAEVGKGEQ 325
+ ++EK + + E KS + E K K K P+ +E + + + G+ +
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVRE 63
Query: 326 KEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET 385
+E + +E + +E++ + +E++ + ++ E V+E+ +V V+ +
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEG----QVREQEGQVREQE-GQVREQEGQVREQEGQVR 118
Query: 386 KEEGKPLQQEKEKEKAGG-----EGG-SEEEGSDKGAKGSRKEDIAVNGEVEG--KEEVE 437
++EG+ +QE + + G EG E+EG + +G +E E EG +E+
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 438 QETKEKGSGREEEKGVVTNGLDLSPADEKKGG-----DKSEEKVVVTKTVEKITSEGGDG 492
Q +++G RE+E + + +E+ G K EE++ + + E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 493 ATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540
+ + K QK EE EE++ ++ + ++K+ Q++
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTE 286
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 96.7 bits (239), Expect = 5e-20
Identities = 65/125 (52%), Positives = 77/125 (61%), Gaps = 12/125 (9%)
Query: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITG------PLYTHRPPI 54
MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFST SI+G P Y PP
Sbjct: 372 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYL-LPPR 430
Query: 55 TISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEK-SEMEEALTAITEELAVSMKEEKK 113
+S+ K LK + EE E +KV +K S++ E+ I EE +S K+ +K
Sbjct: 431 ILSATTSKVSSTGLSLKKE----EEEEEASKVASKKTSQIGESFEEILEETVISTKKTEK 486
Query: 114 EAAEE 118
EE
Sbjct: 487 SNIEE 491
Score = 29.6 bits (65), Expect = 7.3
Identities = 16/54 (29%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 471 KSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV 524
K EE+ +K K TS+ G+ + + ++V T+K E + EE +S++K+
Sbjct: 448 KEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTE--KSNIEETTISSQKI 499
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 95.1 bits (235), Expect = 1e-19
Identities = 94/406 (23%), Positives = 173/406 (42%), Gaps = 41/406 (10%)
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA 125
+ P ++H+ + +E DE+ E E + + + +E +E ++E E E
Sbjct: 639 QRPSSPIRHQGRNDELER----DERRE-ERRVDRVDDRRDERARERDRERERDRERERER 693
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 185
E E ++ + +E E E+E+E +E + + D + ++ E EKE E+
Sbjct: 694 ERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERER 753
Query: 186 EEGEQE---EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
EE E+E E E E E E E A+E K E+ + K++ D + ++ E + P
Sbjct: 754 EERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNP 813
Query: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK------- 295
+ +E+ K +G +SP + S P S G K
Sbjct: 814 RDGHDERKS----KKRYRNEGSPSPRQSPKRRREHS--PDSDAYNSGDDKNEKHRLLSQV 867
Query: 296 -SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE----EEKEVKEAPKEEKVEKKEEKPK 350
P E ++ SP + + + K E K E+KE EE+E+KE K V+K+ E+ +
Sbjct: 868 VRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKE--KVSSVDKQREQTE 925
Query: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410
+ + + +E + +K+ K + KP++++KE + G E G+ E
Sbjct: 926 ILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE-DDVGIERGNIET 984
Query: 411 GSDKG-----AKGSRKEDIAV-------NGEVEGKEEVEQETKEKG 444
S+ G KG +K+ I + ++ +E +Q K++G
Sbjct: 985 TSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRG 1030
Score = 57.0 bits (136), Expect = 4e-08
Identities = 75/411 (18%), Positives = 159/411 (38%), Gaps = 73/411 (17%)
Query: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 167
++E K ++ + EP+ E ++ +++ +E+E K +E E EEE+
Sbjct: 85 LRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEEN--- 141
Query: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE---AKEEKKVEEKSEEVATKEE 224
E + ++ S + E E + ++ + K E++ EK EE+ K+E
Sbjct: 142 -----VEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKE 196
Query: 225 LVADAKVEKPEKAKSPVPKSP-VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283
+ PE +S + SP + + KSP KS SP S ++ K+ S
Sbjct: 197 V-------SPEVVRSKLSPSPSLRKSSKSPKRKS-------SPKSSSASKKDRKTSAVSS 242
Query: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEE-----AKSKAEVGKGEQKEEEEKEVKEAPK 338
P+ ++ ++ + ++ ++P P P+ E K K + ++ EE+ ++ K+ +
Sbjct: 243 PLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGR 302
Query: 339 E-EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVH----------------- 380
+ E+ +K +KP+ + SP+ + S++ H
Sbjct: 303 DFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRT 362
Query: 381 ----------------LEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI 424
L +++ P + +EK G E + R+ED
Sbjct: 363 LTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREK--GRHDHERTSQSHDRRHERRED- 419
Query: 425 AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEK 475
GK + E++++E+ +++ + D P D + D + +
Sbjct: 420 -----TRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTR 465
Score = 53.9 bits (128), Expect = 4e-07
Identities = 65/392 (16%), Positives = 147/392 (37%), Gaps = 45/392 (11%)
Query: 89 EKSEMEEALTAITEELAVSMKEE---KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK 145
EK + T+ + + +E+ K++ ++ EE E E+++ +++ + +
Sbjct: 397 EKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGR 456
Query: 146 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 205
+ ++ + +E + D + + KE ++ + + EG +
Sbjct: 457 DRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTH 516
Query: 206 AKEEKKVEEK--------SEEVA-------TKEELVADAKVEKPEKAKSPVPKSPVEEKG 250
KE+ EE EE + ++ E ++ + ++ +++ VP+ P EKG
Sbjct: 517 RKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELP--EKG 574
Query: 251 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE----------E 300
S ++ + E + P E + S E
Sbjct: 575 SRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDN 634
Query: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV-EKKEEKPKDVPEKKKAE 359
+ + P SP+ E+ + E++EE + + ++E+ E+ E+ +D +++ E
Sbjct: 635 RERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERE 694
Query: 360 SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 419
E + + LE+E E +E+E+EK + D+ +
Sbjct: 695 RERDRE---------REKERELERERARE-----REREREKERDRERDRDRDHDRERERE 740
Query: 420 RKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
R+ D E E +E + +E+ RE E+
Sbjct: 741 RERDREKEREREREERERERERERERERERER 772
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/181 (24%), Positives = 89/181 (49%), Gaps = 14/181 (7%)
Query: 58 SKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELA---VSMKEEKKE 114
S++ +P+ E+ L H E+ K ED K E +E+ E+ VS ++++E
Sbjct: 865 SQVVRPQ-ESRSLSPSH-LTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQRE 922
Query: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ--EEEEEEDEGAKSDQA 172
E E ++ + +S + T+ +E +K + + + ++++E+D G +
Sbjct: 923 QTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNI 982
Query: 173 E---EGG---SEKEGSSEKE-EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
E E G S K+G +K E ++++ + +++ EEA + +KK ++ + TKEEL
Sbjct: 983 ETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEEL 1042
Query: 226 V 226
V
Sbjct: 1043 V 1043
Score = 44.7 bits (104), Expect = 2e-04
Identities = 56/287 (19%), Positives = 113/287 (39%), Gaps = 25/287 (8%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
EEI E+ D E ++ E + S ++ K +E P+++ K+
Sbjct: 805 EEIREDRNPRDGHDE-RKSKKRYRNEGSPSPRQSPKR---RREHSPDSDAYNSGDDKNEK 860
Query: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
+V + + E+ + + D+ E KE S EE E +E +
Sbjct: 861 HRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPE---RKESSRRYEEQELKEKVSSV 917
Query: 198 EAEGEEAEAKEEKKVE-------EKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKG 250
+ + E+ E E ++ +SE+ T + D +K + K P+ K ++ G
Sbjct: 918 DKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-AHDENKKKAKIQKKPIKKKKEDDVG 976
Query: 251 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS-KSPVEEKAKSPVPKS 309
+ + +E + SP + + K + K + KG S +S + ++ K P++
Sbjct: 977 ---IERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRT 1033
Query: 310 PVEEAKSK-AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK 355
P K + E+ G+ E+ + K+E + +DVP++
Sbjct: 1034 PPITTKEELVEMCNGKNGILEDSQ-----KKEDTAFSDWSDEDVPDR 1075
Score = 38.1 bits (87), Expect = 0.021
Identities = 39/212 (18%), Positives = 89/212 (41%), Gaps = 19/212 (8%)
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVS---MKEEKKEAAEEKEEE 122
++PK + +H + ++EK + + E ++S + E+++ +E++ +
Sbjct: 836 QSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRK 895
Query: 123 PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGS 182
PE +E ++ +K V + Q E+ E E ++ + G +
Sbjct: 896 PERKESSRRYEEQELKEKVSSVDK----------QREQTEILESSRMRAQDIIGHHQSED 945
Query: 183 SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA--KSP 240
E + +E + +A+ + + + K+E V + + T E D +V P+K K
Sbjct: 946 RETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSE---DGQVFSPKKGQKKKS 1002
Query: 241 VPKSPVEEKGKSPV-PKSPVEEKGKSPVPKSP 271
+ K + KG S + + ++ K P++P
Sbjct: 1003 IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTP 1034
Score = 29.3 bits (64), Expect = 9.6
Identities = 30/138 (21%), Positives = 53/138 (38%), Gaps = 8/138 (5%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
E +I ++ D + + + E +V E K E E++ E + +A K +
Sbjct: 1360 ERLISDSVERDRDRDRDRTFESSQIE-SVKRCEAKLEGEHERDLE-STSRDSLALDKERM 1417
Query: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
V+ E + E + E +DE D G EG + E +E
Sbjct: 1418 DKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDE----- 1472
Query: 198 EAEGEEAEAKEEKKVEEK 215
+AE +E+++ EEK
Sbjct: 1473 -ILAGDAEKREDQQDEEK 1489
>gi|27262628 nuclear autoantigenic sperm protein isoform 2 [Homo
sapiens]
Length = 788
Score = 93.6 bits (231), Expect = 4e-19
Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%)
Query: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 129
++++ + +E VE+E+ E E E L + +EA EE +E+ +A E+
Sbjct: 100 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 154
Query: 130 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 168
AKK+ K+ A PE +E+ + E+ G+E+ + E E AK
Sbjct: 155 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 214
Query: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 227
A EG +E E +S K E E + E E G + + + EK +EK EV E
Sbjct: 215 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 271
Query: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287
EKP++ P +E++G + VE + P K PV+ G P K E
Sbjct: 272 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 322
Query: 288 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 347
+ K+ +E+ VP P EE+ E EV E P +E ++
Sbjct: 323 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 377
Query: 348 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 403
+ P ++P++ + E +T TK LE++ + + P Q+E E+ +A G
Sbjct: 378 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 436
Query: 404 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 461
+G + K K IA N E + +EE +E +E +GS ++++ T +
Sbjct: 437 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 496
Query: 462 PADEKKGGDKSEEKVV 477
E K ++EE+ +
Sbjct: 497 SVLENKSLQENEEEEI 512
Score = 69.7 bits (169), Expect = 6e-12
Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%)
Query: 129 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 181
E+A ++ V A E V+EEEGEK E+E E + DE A+ + Q + EKE
Sbjct: 97 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 156
Query: 182 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
+ + E+ + ET+ E + E E +E+ + + +EE K +L D E E+AK
Sbjct: 157 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 215
Query: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
G +P + P E
Sbjct: 216 ------------------------------------------------GAAP--EGPNEA 225
Query: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 356
+ S P+ V +A+ + V + +EE ++ + + E + EEKPK+V E++
Sbjct: 226 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 285
Query: 357 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 396
+AES PV +E +VVT ++ K LE+ +E P ++
Sbjct: 286 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 345
Query: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 443
E E + E GS+ K ++ +D AVNG +E + +E+ T+ K
Sbjct: 346 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 405
Query: 444 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 498
GSG EE+ LS + + GD + KV T EK + A T
Sbjct: 406 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 464
Query: 499 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 534
+ K E E EE K E++ + ++++
Sbjct: 465 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 500
Score = 58.9 bits (141), Expect = 1e-08
Identities = 91/359 (25%), Positives = 144/359 (40%), Gaps = 55/359 (15%)
Query: 55 TISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEA----LTAITEELAVSMKE 110
T + KP+ + + K E ++ +K +E E + LT +EE
Sbjct: 160 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 219
Query: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE---EEEEDEGA 167
E AE +PE E + +KS + +V+EE EK +E Q E EE
Sbjct: 220 EGPNEAEVTSGKPEQEVPDAEEEKS---VSGTDVQEECREKGGQEKQGEVIVSIEEKPKE 276
Query: 168 KSDQAEEGGSEKEGSSEKEEGEQ-------------EEGETEAEAEGEEAEAKEEKKV-- 212
S++ EK+G++ + E E E E +E E +A E+ V
Sbjct: 277 VSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQ 336
Query: 213 ----EEKSEEVATK--EELVADAKVEKPEKAKSPVPKSPVEEKGKSPV---PKSPVE--- 260
E+S EV T+ E +A E EK P P + P ++P+E
Sbjct: 337 EVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQT 396
Query: 261 --EKGKSPVPKSPVEEKGKSPVPKSPVEEK---GKSPVSKSPVEEK-AKSPVPKSPVEEA 314
E+ S +EEK ++ + S E K +S + V+ K A+ KSP
Sbjct: 397 SIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---- 452
Query: 315 KSKAEVGKGEQKEEEEKEVKEAPKEEKVE-------KKEEKPKD-VPEKKKAESPVKEE 365
+ K ++ E+ +E E+++KE + E E K EE P D V E K + +EE
Sbjct: 453 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 511
Score = 53.9 bits (128), Expect = 4e-07
Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%)
Query: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
P + + P V + ++ + E + ETK + S +EE + A V +EE
Sbjct: 372 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 424
Query: 112 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 164
K + EE E + + +VA +KSP EE E+EE+ EG+E E EE+D
Sbjct: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 484
Query: 165 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 208
+ ++D+ EE S E S +E E+E G E A+ + E KE
Sbjct: 485 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 542
Query: 209 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
E VE ++ A +E E+ +A + + G + S +E
Sbjct: 543 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 602
Query: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 320
V E + + + E +G S K +EE K P + +E+AK
Sbjct: 603 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 662
Query: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 379
G + + V+ + + +K + V ++ + K K
Sbjct: 663 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 722
Query: 380 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 435
E K++ K +QE E G+ G E ++ A+ + AV G VE
Sbjct: 723 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 782
Query: 436 VE 437
VE
Sbjct: 783 VE 784
Score = 39.7 bits (91), Expect = 0.007
Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
+KP EAP L + + E E LT + + K K ++E
Sbjct: 365 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 424
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
+ EE E A K ++ +K + EE +E +E K
Sbjct: 425 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 472
Query: 181 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 228
EGE+ EG E + E ++ E E K ++E EE EL D
Sbjct: 473 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 520
>gi|27262634 nuclear autoantigenic sperm protein isoform 1 [Homo
sapiens]
Length = 790
Score = 93.6 bits (231), Expect = 4e-19
Identities = 110/436 (25%), Positives = 186/436 (42%), Gaps = 52/436 (11%)
Query: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEEPEAEEEE 129
++++ + +E VE+E+ E E E L + +EA EE +E+ +A E+
Sbjct: 102 RMENGVLGNALEGVHVEEEEGEKTE-----DESLVENNDNIDEEAREELREQVYDAMGEK 156
Query: 130 VAAKKSPVKATA-PEVKEEEGEKEEEEGQEEEE--------------------EEDEGAK 168
AKK+ K+ A PE +E+ + E+ G+E+ + E E AK
Sbjct: 157 EEAKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAK 216
Query: 169 SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVA 227
A EG +E E +S K E E + E E G + + + EK +EK EV E
Sbjct: 217 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIE--- 273
Query: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287
EKP++ P +E++G + VE + P K PV+ G P K E
Sbjct: 274 ----EKPKEVSEEQPVVTLEKQGTA----VEVEAESLDPTVK-PVDVGGDEPEEKVVTSE 324
Query: 288 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 347
+ K+ +E+ VP P EE+ E EV E P +E ++
Sbjct: 325 ---NEAGKAVLEQLVGQEVP--PAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKD 379
Query: 348 KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEK----EKEKAGG 403
+ P ++P++ + E +T TK LE++ + + P Q+E E+ +A G
Sbjct: 380 GAVNGPSVVGDQTPIEPQTSIERLTETKDGS-GLEEKVRAKLVPSQEETKLSVEESEAAG 438
Query: 404 EGGSEEEGSDKGAKGSR-KEDIAVNGEVEGKEEVEQETKE-KGSGREEEKGVVTNGLDLS 461
+G + K K IA N E + +EE +E +E +GS ++++ T +
Sbjct: 439 DGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPND 498
Query: 462 PADEKKGGDKSEEKVV 477
E K ++EE+ +
Sbjct: 499 SVLENKSLQENEEEEI 514
Score = 69.7 bits (169), Expect = 6e-12
Identities = 109/456 (23%), Positives = 180/456 (39%), Gaps = 102/456 (22%)
Query: 129 EVAAKKSPVKATAPE---VKEEEGEKEEEEGQEEEEEE-DEGAKSD---QAEEGGSEKEG 181
E+A ++ V A E V+EEEGEK E+E E + DE A+ + Q + EKE
Sbjct: 99 ELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDEEAREELREQVYDAMGEKEE 158
Query: 182 SSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
+ + E+ + ET+ E + E E +E+ + + +EE K +L D E E+AK
Sbjct: 159 AKKTEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKG- 217
Query: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
G +P + P E
Sbjct: 218 ------------------------------------------------GAAP--EGPNEA 227
Query: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK---- 356
+ S P+ V +A+ + V + +EE ++ + + E + EEKPK+V E++
Sbjct: 228 EVTSGKPEQEVPDAEEEKSVSGTDVQEECREKGGQEKQGEVIVSIEEKPKEVSEEQPVVT 287
Query: 357 ----------KAES------PVK---EEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEK 396
+AES PV +E +VVT ++ K LE+ +E P ++
Sbjct: 288 LEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQEVPPAEESP 347
Query: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-----EDIAVNG--------EVEGKEEVEQETKEK 443
E E + E GS+ K ++ +D AVNG +E + +E+ T+ K
Sbjct: 348 EVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK 407
Query: 444 -GSGREEEKGV----VTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 498
GSG EE+ LS + + GD + KV T EK + A T
Sbjct: 408 DGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGAT-EKSPEDKVQIAANEET 466
Query: 499 KSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVK 534
+ K E E EE K E++ + ++++
Sbjct: 467 QEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLE 502
Score = 58.9 bits (141), Expect = 1e-08
Identities = 91/359 (25%), Positives = 144/359 (40%), Gaps = 55/359 (15%)
Query: 55 TISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEA----LTAITEELAVSMKE 110
T + KP+ + + K E ++ +K +E E + LT +EE
Sbjct: 162 TEDKSLAKPETDKEQDSEMEKGGREDMDISKSAEEPQEKVDLTLDWLTETSEEAKGGAAP 221
Query: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE---EEEEDEGA 167
E AE +PE E + +KS + +V+EE EK +E Q E EE
Sbjct: 222 EGPNEAEVTSGKPEQEVPDAEEEKS---VSGTDVQEECREKGGQEKQGEVIVSIEEKPKE 278
Query: 168 KSDQAEEGGSEKEGSSEKEEGEQ-------------EEGETEAEAEGEEAEAKEEKKV-- 212
S++ EK+G++ + E E E E +E E +A E+ V
Sbjct: 279 VSEEQPVVTLEKQGTAVEVEAESLDPTVKPVDVGGDEPEEKVVTSENEAGKAVLEQLVGQ 338
Query: 213 ----EEKSEEVATK--EELVADAKVEKPEKAKSPVPKSPVEEKGKSPV---PKSPVE--- 260
E+S EV T+ E +A E EK P P + P ++P+E
Sbjct: 339 EVPPAEESPEVTTEAAEASAVEAGSEVSEKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQT 398
Query: 261 --EKGKSPVPKSPVEEKGKSPVPKSPVEEK---GKSPVSKSPVEEK-AKSPVPKSPVEEA 314
E+ S +EEK ++ + S E K +S + V+ K A+ KSP
Sbjct: 399 SIERLTETKDGSGLEEKVRAKLVPSQEETKLSVEESEAAGDGVDTKVAQGATEKSP---- 454
Query: 315 KSKAEVGKGEQKEEEEKEVKEAPKEEKVE-------KKEEKPKD-VPEKKKAESPVKEE 365
+ K ++ E+ +E E+++KE + E E K EE P D V E K + +EE
Sbjct: 455 EDKVQIAANEETQEREEQMKEGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEE 513
Score = 53.9 bits (128), Expect = 4e-07
Identities = 96/422 (22%), Positives = 159/422 (37%), Gaps = 45/422 (10%)
Query: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
P + + P V + ++ + E + ETK + S +EE + A V +EE
Sbjct: 374 PVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETK---DGSGLEEKVRA----KLVPSQEE 426
Query: 112 KKEAAEEKEEEPEAEEEEVA---AKKSPVKATAPEVKEEEGEKEEE--EGQEEE--EEED 164
K + EE E + + +VA +KSP EE E+EE+ EG+E E EE+D
Sbjct: 427 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMKEGEETEGSEEDD 486
Query: 165 EGAKSDQAEE--GGSEKEGSSEKEEGEQEEGETE--------AEAEGEEAEAKE------ 208
+ ++D+ EE S E S +E E+E G E A+ + E KE
Sbjct: 487 K--ENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAA 544
Query: 209 -------EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 261
E VE ++ A +E E+ +A + + G + S +E
Sbjct: 545 QAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDE 604
Query: 262 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-KAKSPVPKSPVEEAKSKAEV 320
V E + + + E +G S K +EE K P + +E+AK
Sbjct: 605 AVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRS 664
Query: 321 GKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV-TITKSVKV 379
G + + V+ + + +K + V ++ + K K
Sbjct: 665 GNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKP 724
Query: 380 HLEKETKEEGKPLQQEKEKEKAGGE----GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 435
E K++ K +QE E G+ G E ++ A+ + AV G VE
Sbjct: 725 EEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGAT 784
Query: 436 VE 437
VE
Sbjct: 785 VE 786
Score = 39.7 bits (91), Expect = 0.007
Identities = 40/174 (22%), Positives = 60/174 (34%), Gaps = 24/174 (13%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
+KP EAP L + + E E LT + + K K ++E
Sbjct: 367 EKPGQEAPVLPKDGAVNGPSVVGDQTPIEPQTSIERLTETKDGSGLEEKVRAKLVPSQEE 426
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
+ EE E A K ++ +K + EE +E +E K
Sbjct: 427 TKLSVEESEAAGDGVDTKVAQGATEKSPEDKVQIAANEETQEREEQMK------------ 474
Query: 181 GSSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVAD 228
EGE+ EG E + E ++ E E K ++E EE EL D
Sbjct: 475 ------EGEETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWD 522
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 92.4 bits (228), Expect = 9e-19
Identities = 99/325 (30%), Positives = 146/325 (44%), Gaps = 50/325 (15%)
Query: 53 PITISSKIQKPKVE---APKLKVQHKFVEEIIEETK-----VEDEKSEMEEALTAITEEL 104
P T S K +K E + +L+ + ++E+ E++ ED ++E+++ EE
Sbjct: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE-DGEKEET 122
Query: 105 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE-- 162
V +E E K E EAEE+E KA E K E G+K + +++ E
Sbjct: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
Query: 163 --EDEGAKSDQAEEGGSEKEGSSE-KEEGEQEEG---------ETEAEAEGEEAEAKEEK 210
E+E AK+ EE G KE S+E KE+ EE E EA+AE +E + KEE
Sbjct: 183 TVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
Query: 211 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
K K E ADAK E+ E A+ P SP EE+ + V K P E G +P S
Sbjct: 243 KHGAKEE---------ADAK-EEAEDAEEAEPGSPSEEQ-EQDVEKEP--EGGAGVIPSS 289
Query: 271 PVEEKGKSPVPKS-PVEEKGKSP------VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 323
P EE +SP + + G P + E + S VP+SP E S G
Sbjct: 290 P-EEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS------G 342
Query: 324 EQKEEEEKEVKEAPKEEKVEKKEEK 348
E+KE+ + AP + + + +
Sbjct: 343 EKKEKAPERRVSAPARPRGPRAQNR 367
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/348 (27%), Positives = 145/348 (41%), Gaps = 27/348 (7%)
Query: 116 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175
A EK E+ E + E SP A PE+ EE +G + + +E
Sbjct: 15 AREKMEQKEGKLSEDGTTVSPA-ADNPEMSGGGAPAEETKGTAGKAINEGPPTESGKQEK 73
Query: 176 GSEKEGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAK--VE 232
++G S + +GE G E + E + EA KE+ + E K E+ KEE ++
Sbjct: 74 APAEDGMSAELQGEAN-GLDEVKVESQREAGGKEDAEAELKKED-GEKEETTVGSQEMTG 131
Query: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGK 290
+ E+ KS PK E++ K EEK P K+ ++ K P PK+ VEE+
Sbjct: 132 RKEETKSE-PKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK-PEPKATVEEEDA 189
Query: 291 SPVSKSPV-EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349
S+ + K S PK + ++KAE QK E E K PKE + KEE
Sbjct: 190 KTASQEETGQRKECSTEPKEKATDEEAKAE----SQKAVVEDEAKAEPKEP--DGKEEAK 243
Query: 350 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK---PLQQEKEKEKAGGEG- 405
E+ A+ ++ AE + ++ + +EKE E G P E+ E GEG
Sbjct: 244 HGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKE-PEGGAGVIPSSPEEWPESPTGEGH 302
Query: 406 --GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
++ G D A G + E + + + SG ++EK
Sbjct: 303 NLSTDGLGPDCVASGQTSPSAS---ESSPSDVPQSPPESPSSGEKKEK 347
Score = 72.0 bits (175), Expect = 1e-12
Identities = 84/300 (28%), Positives = 129/300 (43%), Gaps = 43/300 (14%)
Query: 99 AITEELAVSMKEEKKEAAEEKEEE------PEAEEEEVAAKKSPVKATAPEVKE------ 146
A+ E + EK E E K E P A+ E++ +P + T +
Sbjct: 5 AVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEGP 64
Query: 147 --EEGEKEE---EEG-----QEEEEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEG-- 193
E G++E+ E+G Q E DE Q E GG E E +KE+GE+EE
Sbjct: 65 PTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTV 124
Query: 194 --------ETEAEAEGEEAEAKEEKKVEEK--SEEVATKEELVADAKVEKPEKAKSPVPK 243
+ E ++E +EAE KE EK +EE K E A +K P PK
Sbjct: 125 GSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDK---PEPK 181
Query: 244 SPVEEK-GKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 301
+ VEE+ K+ + + K S PK +E+ K+ K+ VE++ K+ + +E+
Sbjct: 182 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEE 241
Query: 302 AKSPVPK--SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
AK + EEA+ E G EE+E++V++ P E P++ PE E
Sbjct: 242 AKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEP-EGGAGVIPSSPEEWPESPTGE 300
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/319 (24%), Positives = 128/319 (40%), Gaps = 60/319 (18%)
Query: 193 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252
GE++ AE E ++E K+ E V+ + PE + P +
Sbjct: 7 GESDCSAEAREKMEQKEGKLSEDGTTVSPA--------ADNPEMSGGGAPAEETKGTAGK 58
Query: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVP-----------KSPVEEKGKSPVSKSPVEEK 301
+ + P E GK K+P E+ + + +S E GK +E
Sbjct: 59 AINEGPPTESGKQE--KAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKED 116
Query: 302 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK-----DVPEKK 356
+ +E + E K E KE EEKE A +++K E+KE KP+ D ++
Sbjct: 117 GEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRD 176
Query: 357 KAE--SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
K E + V+EE K ++ET + + + KEK ++EE +
Sbjct: 177 KPEPKATVEEE----------DAKTASQEETGQRKECSTEPKEK-------ATDEEAKAE 219
Query: 415 GAKGSRKEDI-AVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE 473
K +++ A E +GKEE + KE+ +EE + A+E + G SE
Sbjct: 220 SQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAE----------DAEEAEPGSPSE 269
Query: 474 EKVVVTKTVEKITSEGGDG 492
E+ + VEK EGG G
Sbjct: 270 EQ---EQDVEK-EPEGGAG 284
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 91.7 bits (226), Expect = 2e-18
Identities = 99/405 (24%), Positives = 188/405 (46%), Gaps = 27/405 (6%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK----KEAA 116
QK + + ++ Q + + E E + +++ E EE + EE + +E+K +E
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQ---EEERIREREKKMREEEETM 408
Query: 117 EEKEEEPEAEEEEV--AAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
E+EE+ + +EE + +K + PE KE+ E+E+ + QEE+ E E DQ E
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468
Query: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK---EEKKVEEKSEEVATKEELVADAKV 231
G EK+ +++ EQE+ E E + + E K +E+++ E+ E + KEE + + K
Sbjct: 469 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKK 528
Query: 232 --EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 289
++ EK + E+K K EE+ + K EE+ + + E+
Sbjct: 529 MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE----MMREQEEKMQ 584
Query: 290 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEA----PKEEKVEKK 345
+ EEK K +E K + K ++EEE+K ++ +EEK++++
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 346 EEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEG 405
EEK + EK + + E ++ + ++ E+E K +G+ + +++EK G+
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR---EQEEKMQGQEEKMREQEEKMRGQ- 700
Query: 406 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
E+ + ++E + E+ KEE ++ KEK R E
Sbjct: 701 -EEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/531 (22%), Positives = 228/531 (42%), Gaps = 43/531 (8%)
Query: 6 REYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKV 65
R ++L + AL +E+ YR + EE + + L R + S+IQ
Sbjct: 159 RYIEELTKERDALSLEL--YRNTITNEELKKKN--AELQEKL---RLAESEKSEIQLNVK 211
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK--EEEP 123
E + + KF+ ++ +++E EE L +E + +EEK EE+ E+E
Sbjct: 212 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE--QEKKIRKQEEKMWRQEERLREQEG 269
Query: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183
+ E+E ++ + E + E EKE E ++ E+E++ + ++ EK
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 184 EKEEGEQEEGETEAEAEGEEAEAK---EEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
E++ QEE E E + E E K +E+++ E+ E + KEE ++ + EK
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE-----RMREQEKMWEQ 384
Query: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
K EE+ + K EE+ + +++ + ++ + P K + E
Sbjct: 385 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 444
Query: 301 KAKSPVPKSPVEEAKSK---------AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351
+ K + + E + K E Q++ E+E + +EEK+ +E+K D
Sbjct: 445 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 504
Query: 352 VPEKKKAESP---VKEEAVAEVVTI-TKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGS 407
E+ + KEE + E + + K+ EK+T+E+ K ++EK +
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR------- 557
Query: 408 EEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGR-EEEKGVVTNGLDLSPADEK 466
EEE + K R+E+ + + E +E E++ +E+ E+E+ + + +EK
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Query: 467 KGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 517
+ E+K+ + E++ E + + K +K+ E EE E+
Sbjct: 618 MWEQEEEDKM---QEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Score = 76.3 bits (186), Expect = 7e-14
Identities = 91/408 (22%), Positives = 190/408 (46%), Gaps = 27/408 (6%)
Query: 62 KPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 121
K + + K++ Q K + E +E ++ +++ E+ E +E + +EEK EEK
Sbjct: 270 KMREQEEKMRRQEKRLRE--QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMR 327
Query: 122 EPEA----EEEEVAAKKSPVKATAPEVKEEEGE--KEEEEGQEEEEEEDEGAKSDQAEEG 175
E E +EE + ++ ++ +++++E +++E +E+EE E K + EE
Sbjct: 328 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Query: 176 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE------VATKEELVADA 229
E+E E+E+ +EE ET E E E+ + +EE E++ +E KE+L
Sbjct: 388 MQEEERIREREKKMREEEETMREQE-EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 446
Query: 230 KV-EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 288
K+ E+ EK K +E+ K +EK + + +E+ + +++
Sbjct: 447 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 506
Query: 289 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 348
+ + EK + + + + + K E+K+ +E+E K +EEK+ ++EE+
Sbjct: 507 ERMWEQDERLREKEERMREQKKMWQQEEKMR----EEKKTQEQEKKTWDQEEKM-REEER 561
Query: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSE 408
++ +K + E + E ++ + ++ EK ++E K +Q+++EK E E
Sbjct: 562 MREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK-MQEQEEKMWEQEEKMWE 620
Query: 409 EEGSDKGAKGS-----RKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
+E DK + ++E + E ++E + +E+ +EEK
Sbjct: 621 QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668
Score = 74.7 bits (182), Expect = 2e-13
Identities = 105/467 (22%), Positives = 201/467 (43%), Gaps = 36/467 (7%)
Query: 74 HKFVEEIIEETKVEDEKSEMEEALTAIT-EELAVSMKE--EKKEAAEEKEEEPEAEEEEV 130
HK + IEE E + +E IT EEL E EK AE ++ E + +E+
Sbjct: 154 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 131 AAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ 190
K K P+V + +EE ++EEE ++ K + EE +E ++EG+
Sbjct: 214 KRKLERAKFLLPQV--QTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 271
Query: 191 EEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKG 250
E E + + E+ ++EK++ E+ +E+ +++L + ++ + + EEK
Sbjct: 272 REQEEKMRRQ-EKRLREQEKELREQEKELREQKKL----REQEEQMQEQEEKMWEQEEKM 326
Query: 251 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP 310
+ K +E+ K E++ K + + E+ + K EE+ +
Sbjct: 327 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK---EERMREQEKMWE 383
Query: 311 VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK--KKAESPVKEEAVA 368
EE + E + +K+ E+E +EEK++K+EE + EK ++ P ++E +
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 443
Query: 369 EVVTITKSVKVHLEKETK---------EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 419
E + + + E+E K +E K +QEK +E+ EE+ D+ K
Sbjct: 444 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 420 RKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSE------ 473
+E+ + +E+ E+ ++K ++EEK + EKK D+ E
Sbjct: 504 DQEERMWEQDERLREKEERMREQKKMWQQEEK---MREEKKTQEQEKKTWDQEEKMREEE 560
Query: 474 ---EKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 517
E+ + E++ E + + K +K+ E EE +E+
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQ 607
Score = 61.6 bits (148), Expect = 2e-09
Identities = 39/187 (20%), Positives = 98/187 (52%), Gaps = 7/187 (3%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Q+ K++ + K++ + + +E K+++++ +M E + E+ +E++E E+E
Sbjct: 579 QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQE 638
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
E+ + +EE++ ++ ++ +++E+E + + +E + E+EE + ++ E +
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Query: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
G EK G++E + G+E + ++++ EK E + ++E + + E E+ P
Sbjct: 699 GQEEKMWGQEE------KMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEP 752
Query: 241 -VPKSPV 246
+P S V
Sbjct: 753 CLPPSKV 759
Score = 56.6 bits (135), Expect = 6e-08
Identities = 56/214 (26%), Positives = 107/214 (50%), Gaps = 36/214 (16%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKS-EMEEALTAITEELAVSMKEEKKEAAEEK 119
+K + E ++ Q + ++E E+ + ++EK E EE + +E M E++++ E++
Sbjct: 567 KKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM----QEQEEKMWEQEEKMWEQE 622
Query: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
EE+ E+EE+ ++ EE+ +++EE+ E+EE+ E + + +E +
Sbjct: 623 EEDKMQEQEEMMWEQ-----------EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQG 671
Query: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV---EEK----------SEEVATKEELV 226
+ +E+ E+ +G+ E E EE +E+K+ EEK EE+ KEE +
Sbjct: 672 QEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERI 731
Query: 227 ADAKVEKPEKAKSPVPKSPVEEKGKSP-VPKSPV 259
D K EK + +P+ EE+ P +P S V
Sbjct: 732 RDQK----EKMQERLPEH--EERCSEPCLPPSKV 759
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 90.1 bits (222), Expect = 5e-18
Identities = 123/498 (24%), Positives = 223/498 (44%), Gaps = 42/498 (8%)
Query: 70 LKVQHKFVEEIIEETKVEDEKSEMEEALTAIT-EELAVSMKE--EKKEAAEEKEEEPEAE 126
+ +HK + IEE E + +E IT EEL E EK AE ++ E +
Sbjct: 188 VSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLN 247
Query: 127 EEEVAAKKSPVKATAPEV-----KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 181
+E+ K K P+V +EE +EEE ++E++ + K + EE E+EG
Sbjct: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307
Query: 182 SSEKEE-----GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK 236
++E E+ E E E +E E +E+K++ E+ E++ +EE + E+ EK
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM----WEQEEK 363
Query: 237 AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV---EEKGKSPVPKSPVEEKGKSPV 293
+ K +E+ K E++ K + + +E+ + + +EK V
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423
Query: 294 SKSPVEEKAKSPVPKSPVEEAKSKAE--VGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351
K E+K + K+ +E K + E + + E+K EE+E +EEK++K+EE +
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR-EQEEKMQKQEENMWE 482
Query: 352 VPEK--KKAESPVKEEAVAEVVTITKSVKVHLEKETK---------EEGKPLQQEKEKEK 400
EK ++ P ++E + E + + + E+E K +E K +QEK +E+
Sbjct: 483 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 542
Query: 401 AGGEGGSEEEGSDKGAK-GSRKEDIAVNGEVEGKEEVEQETK--EKGSGREEEKGVVTNG 457
EE+ D+ K ++E + + + K+ +QE K E+ RE EK +
Sbjct: 543 EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 602
Query: 458 LDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 517
+ +EK + EEK+ + E+ E + + K +K+ E EE E+
Sbjct: 603 EMMREQEEKM--QEQEEKM---QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657
Query: 518 LVSTKKVEKVTSHAIVKE 535
++ EK+ H ++E
Sbjct: 658 QRLPEQKEKLWEHEKMQE 675
Score = 89.7 bits (221), Expect = 6e-18
Identities = 125/546 (22%), Positives = 233/546 (42%), Gaps = 69/546 (12%)
Query: 6 REYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLY-THRPPITISSKIQKPK 64
R ++L + AL +E+ YR + EE + PL + + I ++ K K K
Sbjct: 197 RYIEELTKERDALSLEL--YRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRK 254
Query: 65 VEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK--EEE 122
+E + KF+ ++ +++E EE L +E + +EEK EE+ E+E
Sbjct: 255 LE------RAKFLLPQVQTNTLQEEMWRQEEELRE--QEKKIRKQEEKMWRQEERLREQE 306
Query: 123 PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGS 182
+ E+E + + E + E EKE E +E E+E++ + ++ EK
Sbjct: 307 GKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 183 SEKEEGEQEEGETEAEAEGEEAEAK---EEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
E++ QEE E E + E E K +E+++ E+ E + KEE ++ + EK
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE-----RMREQEKMWE 421
Query: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
V K E+K + E+K + K EE+ + K EE+ + E
Sbjct: 422 QVEKMREEKKMQEQ------EKKTRDQEEKMQEEERIREREKKMREEEE-----TMREQE 470
Query: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
EK + +E K + EQKE+ ++ K +EEK+ ++EEK +D E E
Sbjct: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
Query: 360 SPV---------------KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
+ +EE + + + +EK+T+E+ K ++EK +
Sbjct: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR---- 586
Query: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 464
EEE + K R+E+ + + E +E E++ +E+ E++ + +
Sbjct: 587 ---EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ 643
Query: 465 EKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHE--ETFEEKLVSTK 522
E+K ++ E+ + E+ + + +K++E E + EEK+ +
Sbjct: 644 EEKMWEQEEKMWEQQRLPEQ-------------KEKLWEHEKMQEQEKMQEQEEKIWEQE 690
Query: 523 KVEKVT 528
K+EK T
Sbjct: 691 KMEKKT 696
Score = 88.2 bits (217), Expect = 2e-17
Identities = 94/382 (24%), Positives = 176/382 (46%), Gaps = 20/382 (5%)
Query: 82 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATA 141
EE E EK E+ +E + ++E+ EE+ E E E+V + K
Sbjct: 375 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
Query: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG---EQEEGETEAE 198
E K + +EE+ QEEE + K + EE E+E +K+E EQEE E + +
Sbjct: 435 QEKKTRD---QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 199 AEGEEAEAK-EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
E+ E E++K++E+ E++ +EE + D + ++ K + E++ + +
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 258 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK 317
+ ++ + + EK K +++ K + E + K + + E + K
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 318 AEVGKGEQKEEEEK----EVKEAPKEEKVEKKEEKPKDVPEK--KKAESPVKEEAVAEVV 371
+ + + +E+EEK E K +EEK+ ++EEK + EK ++ P ++E + E
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 372 TITKSVKVHLEKE---TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNG 428
+ + K+ ++E +E+ + QE+EK+ E EEE + K R+E+ +
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
Query: 429 EVEGKEEVEQETKEKGSGREEE 450
+ EE QE +EK +EEE
Sbjct: 732 Q----EEKMQEQEEKMQEQEEE 749
Score = 87.4 bits (215), Expect = 3e-17
Identities = 102/455 (22%), Positives = 204/455 (44%), Gaps = 55/455 (12%)
Query: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK----KEAAEEKEEEPEAEEEEV-- 130
VE++ EE K+++++ + + + EE + +E+K +E E+EE+ + +EE +
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482
Query: 131 AAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ 190
+K + PE KE+ E+E+ + QEE+ E E DQ E G EK+ +++ EQ
Sbjct: 483 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 542
Query: 191 EEGETEAEAEGEEAEAK---EEKKVEEKSEEVATK-----EELVADAKVEKPEKA----- 237
E+ E E + + E K +E+++E+K++E K E++ + ++ + EK
Sbjct: 543 EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 602
Query: 238 ----KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 293
+ EEK + K +E+ + E++ K + + E+ + P
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 294 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE------------------EKEVKE 335
K + E K + E+ + E K E+K +E E+E K
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722
Query: 336 APKEEKVEKKEEKPKDVPEKKKAESP----------VKEEAVAEVVTITKSVKVHLEKET 385
+EE + ++EEK ++ EK + + +EE + E + + + E E
Sbjct: 723 REEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 782
Query: 386 KEEGKPL--QQEKEKEKAGGEGGSEEE--GSDKGAKGSRKEDIAVNGEVEGKEEVEQETK 441
+E + + Q+EK +++ G EE+ G ++ +G ++ ++ G+EE +
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 842
Query: 442 EKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 476
EK G+EE+ G + ++++ EEK+
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKM 877
Score = 86.3 bits (212), Expect = 7e-17
Identities = 83/396 (20%), Positives = 190/396 (47%), Gaps = 26/396 (6%)
Query: 78 EEIIEETKVEDEKS---EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKK 134
E++ E+ K+++++ E EE + E K ++E E+E++ +EE++ ++
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 135 SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194
+ ++++ E+E++ +EE+ +E ++ ++ E+E E+EE QE+ E
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
Query: 195 TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPV 254
E E E ++E+K++E+ E++ +EE + + + + E+ + P K + E K
Sbjct: 618 KMQEQE--EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ- 674
Query: 255 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEA 314
+ ++E+ + + +E+K + K+ +EK + S E+K + +E
Sbjct: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
Query: 315 KSKAEVGKGEQKEEE--EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 372
K + + K +++EEE E+E K +EEK+ +++ P+ + + E ++E + E
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794
Query: 373 ITKSVKVHLE-KETKEEGKPLQQEKEKEKAGGEGGS-----------------EEEGSDK 414
+ + + +E K G+ + ++EK G+ +EE ++
Sbjct: 795 KMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE 854
Query: 415 GAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
+G ++ ++ G+EE +E +EK G+EE+
Sbjct: 855 KMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 72.4 bits (176), Expect = 1e-12
Identities = 80/309 (25%), Positives = 147/309 (47%), Gaps = 37/309 (11%)
Query: 69 KLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK---EEEPEA 125
K++ + + + E +E K+++++ +M+E + E+ EEK + EEK +EE
Sbjct: 597 KMREEEEMMRE--QEEKMQEQEEKMQEQEEKMWEQ------EEKMQEQEEKMWEQEEKMW 648
Query: 126 EEEEVAAKKSPVKATAPEVKEE--EGEKEEEEGQEEEEEE------------DEGAKSDQ 171
E+EE K + PE KE+ E EK +E+ + +E+EE E K
Sbjct: 649 EQEE----KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 172 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKV 231
+E E+E E+E+ +E E E E EE ++E+K++E+ EE+ +EE + + +
Sbjct: 705 DQEKMREEESMREREKKMRE--EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE 762
Query: 232 EKPEKAKSPVPKSPVEEKGKSPVPKS--PVEEKGKSPVPKSPVEE---KGKSPVPKSPVE 286
+ E+ + P K + E K + EEK + K +E +G+ + E
Sbjct: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE 822
Query: 287 EKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKE 346
+ EEK K +E K + ++ +G++++ E+E K +EEK+ ++E
Sbjct: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKM-QGQEEKMREQEEKMRGQEEKMREQE 881
Query: 347 EKPKDVPEK 355
EK + EK
Sbjct: 882 EKMRGQEEK 890
Score = 55.5 bits (132), Expect = 1e-07
Identities = 42/174 (24%), Positives = 91/174 (52%), Gaps = 10/174 (5%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK- 119
+K + E ++ Q + ++E +E K+++++ EM E + E+ ++++ +EK
Sbjct: 720 KKMREEEEMMREQEEKMQE--QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Query: 120 -EEEPEAEEEEVAAKKSPVKATAPEVKEEE----GEKEEEEGQEEEEEEDEGAKSDQAEE 174
E E E+E++ ++ ++ +++ +E G++E+ GQEE+ E Q E+
Sbjct: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK 837
Query: 175 --GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELV 226
G EK E++ E+ +G+ E E EE +E+K+ E+ E++ +EE +
Sbjct: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/195 (25%), Positives = 96/195 (49%), Gaps = 12/195 (6%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
+K + + K Q K EE E + ++K EE + EE +E++E +E+E
Sbjct: 694 KKTQEQEKKTWDQEKMREE--ESMREREKKMREEEEMMREQEE----KMQEQEEKMQEQE 747
Query: 121 EEPEAEEEEVAAKKSPV--KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
EE +EE++ ++ + + PE KE+ E E+ + QE+ E++E + + + G E
Sbjct: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQE 807
Query: 179 KE--GSSEKEEGEQEE--GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
++ G EK G++E+ G+ E EE +E+K+ + E++ K + + E+
Sbjct: 808 EKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE 867
Query: 235 EKAKSPVPKSPVEEK 249
EK + K +E+
Sbjct: 868 EKMRGQEEKMREQEE 882
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 86.7 bits (213), Expect = 5e-17
Identities = 102/417 (24%), Positives = 197/417 (47%), Gaps = 46/417 (11%)
Query: 56 ISSKIQKPKVEAPKLKVQH------KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMK 109
+ K+++ K+ P+ ++Q K ++ + + + + E++E+ L EE + +
Sbjct: 308 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE-KMWRQ 366
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG---EKEEEEGQEEE---EEE 163
EEK + EEK +E +EE++ ++ ++ +++ +E EKEE+ ++EE E+E
Sbjct: 367 EEKIQEWEEKIQE---QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 423
Query: 164 DEGAKSD-----------QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK---EE 209
++ + + + EE E+E E+EE QEE + + + +E EAK +E
Sbjct: 424 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 483
Query: 210 KKVEEKSEEVATKEELV--ADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 267
+K+ E+ E++ +EE + + K+ + EK + + EE + EE +
Sbjct: 484 EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE 543
Query: 268 PKSPVEEKGKSPVPKS-PVEEKGKSPVSK-SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 325
EEK + K EEK K EEK K +E K + + K +
Sbjct: 544 KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 326 KEE--EEKEVKEAPKEEKVEKKEEKPKDVPEK-KKAESPVKEEAVAEVVTITKSVKVHLE 382
+EE +E+E K +EEK+ ++EEK ++ EK ++ E ++E+ K ++ E
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQ--------EKKIREQEE 655
Query: 383 K-ETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ 438
K +EE Q+EK E+ EE+ ++ K R+E+ EV +++ E+
Sbjct: 656 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Score = 84.0 bits (206), Expect = 3e-16
Identities = 100/458 (21%), Positives = 209/458 (45%), Gaps = 34/458 (7%)
Query: 81 IEETKVEDEKSEMEEALTAITEE---LAVSMKEEKKEAAEEK----EEEPEAEEEEVAAK 133
I + +++++ ++++E L + E + +++KE K++ K +++ +AE + + +
Sbjct: 275 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 334
Query: 134 KSPVKATAP-EVKEEE-----GEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187
V A +V+E E +++EE+ +EE+ E + Q +E ++ +E+
Sbjct: 335 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 394
Query: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 247
E+ + E E EE ++E+ + EK E++ +EE++ EK EK + K +
Sbjct: 395 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW----EKEEKIRELEEKMHEQ 450
Query: 248 EKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVSKS-PVEEKAKSP 305
EK + K EEK + + E K K EEK + K EEK
Sbjct: 451 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQ 510
Query: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEV-----KEAPKEEKVEKKEEKPKDVPEKKKAES 360
E+ + + E+ + E+K E++E+ K +EEK+ K+EEK EK +
Sbjct: 511 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE 570
Query: 361 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
E +V + ++ EK ++E K +QE+ ++ + G +EE + + +
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 630
Query: 421 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 480
+++ + + E E E++ +E +EEK + ++ E+K ++ E+ +
Sbjct: 631 EQEEKMRRQEEKIREQEKKIRE-----QEEK--IREQEEMMQEQEEKMWEQEEKMCEQEE 683
Query: 481 TVEKITSEGGDGATKYITKSVTVTQ---KVEEHEETFE 515
+++ + K + V + Q K++EH+E E
Sbjct: 684 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 72.8 bits (177), Expect = 8e-13
Identities = 73/292 (25%), Positives = 135/292 (46%), Gaps = 15/292 (5%)
Query: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE-VAAKKSPVKA 139
+EE E EK +E E++ K +++EA ++EE E+EE + ++ +
Sbjct: 443 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWR 502
Query: 140 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA 199
++ E+E +EEE+ QE+EE + K + EE +KE E+EE +++ E
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 200 EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV 259
E E +E+K+ E+ E+V +EE + E+ EK + K +E+ + +
Sbjct: 563 E--EKMHDQEEKIREQEEKVWRQEEKIR----EQEEKIREQEEKIREQEE----MTQEQE 612
Query: 260 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 319
E+ G+ EEK + K +E+ K E++ K + ++E + K
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672
Query: 320 VGKGEQKEEEEK----EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
+ + E+EEK E K +EEK+ ++E + + EK + E A+
Sbjct: 673 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/154 (24%), Positives = 79/154 (51%), Gaps = 9/154 (5%)
Query: 61 QKPKVEAPKLKV--QHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE---EKKEA 115
Q+ K+ + KV Q + + E E+ + ++EK +E +T EE +E E++E
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628
Query: 116 AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175
+E+EE+ +EE++ ++ ++ +++E+E +E+E + E+EE K + EE
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE----KMCEQEEK 684
Query: 176 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE 209
E+E ++E + E E + E+ + +E
Sbjct: 685 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/164 (24%), Positives = 85/164 (51%), Gaps = 10/164 (6%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Q+ K+ + K++ + + +E K+ +++ ++ E I E+ M +E++E E+E
Sbjct: 562 QEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQ--EEMTQEQEEKMGEQE 619
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
E+ +EE++ ++ ++ +++E+E + E QEE+ E E +Q E+ ++E
Sbjct: 620 EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE---QEEKIREQEEMMQEQEEKMWEQEE 676
Query: 181 GSSEKEEGEQEEGE-----TEAEAEGEEAEAKEEKKVEEKSEEV 219
E+EE QE+ E E E E ++E+K++E E +
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 50.4 bits (119), Expect = 4e-06
Identities = 38/140 (27%), Positives = 71/140 (50%), Gaps = 3/140 (2%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEK-SEMEEALTAITEELAVSMKEEKKEAAEEK 119
+K + + K++ Q + + E E T+ ++EK E EE + E++ +EEK EEK
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM--QEQEEKMRRQEEK 642
Query: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
E E + E K + E +E+ E+EE+ ++EE+ +++ K + EE E+
Sbjct: 643 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 702
Query: 180 EGSSEKEEGEQEEGETEAEA 199
E ++E + +E + EA
Sbjct: 703 EVRLRQQEEKMQEHQEHLEA 722
Score = 36.2 bits (82), Expect = 0.078
Identities = 25/108 (23%), Positives = 59/108 (54%), Gaps = 3/108 (2%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Q+ K+ + K+Q + + +E K+ +++ ++ E I E+ M +E++E E+E
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ--EEMMQEQEEKMWEQE 675
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGE-KEEEEGQEEEEEEDEGA 167
E+ +EE++ ++ ++ ++ E+E +++EE +E +E E A
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 86.7 bits (213), Expect = 5e-17
Identities = 105/455 (23%), Positives = 185/455 (40%), Gaps = 41/455 (9%)
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEG 166
EE++E + P + +K P V++ + E E E DE
Sbjct: 989 EEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEP 1048
Query: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE--------AEGEEAEAKEEKKVEEKSEE 218
+ +E E + E +E E+EE E E + + + K + K EE
Sbjct: 1049 FEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEE 1108
Query: 219 VATKEELVADAKVEKPEKA--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 276
+ + D + KP K V SP+E +P+ K KGKS P + G
Sbjct: 1109 EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
Query: 277 KSPVPK-----SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 331
+ P K PV + + + + P + E + K ++ E+++EEE+
Sbjct: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEE 1228
Query: 332 EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391
EA + E+ E+++ +VP A+S E T TK +V E+E K
Sbjct: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE------TETKEPEVE-EEEEKPRVSE 1281
Query: 392 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG-------KEEVEQETKEKG 444
Q++ E+E+ E EE D A+ ++ +D + E +G KE EQ T+E
Sbjct: 1282 EQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRE-- 1339
Query: 445 SGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVT 504
+EE GV + LD A+ +K +K ++K +T E T +++ + +
Sbjct: 1340 -DVKEEPGVQESFLD---ANMQKSREKIKDK---EETELDSEEEQPSHDTSVVSEQMAGS 1392
Query: 505 QKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 539
+ E + +E+L+ K+ E++ + E Q+
Sbjct: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQA 1427
Score = 68.2 bits (165), Expect = 2e-11
Identities = 64/276 (23%), Positives = 120/276 (43%), Gaps = 45/276 (16%)
Query: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
P ++I +KPK++ + V+ K E+ + +E+ E EE M+ E
Sbjct: 1191 PIVSIPKAGRKPKIQESEETVEPK------EDMPLPEERKEEEE------------MQAE 1232
Query: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ--------EEEEEE 163
+EA E +EE+ + E A+ + E KE E E+EEE+ + EEE++E
Sbjct: 1233 AEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE 1292
Query: 164 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA------EAEGEEAEAKEEKKVEE--- 214
E + ++ E+ +E + + + ++++G E+ E + + KEE V+E
Sbjct: 1293 LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFL 1352
Query: 215 ------KSEEVATKEELVADAKVEKPEKAKSPVPK----SPVEEKGKSPVPKSPVEEKGK 264
E++ KEE D++ E+P S V + S + + S + +E K +
Sbjct: 1353 DANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEE 1412
Query: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
+P S ++ + V EE + + EE
Sbjct: 1413 EEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEE 1448
Score = 65.1 bits (157), Expect = 2e-10
Identities = 95/466 (20%), Positives = 187/466 (40%), Gaps = 63/466 (13%)
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA 125
E P +++ F + EE + E+E E ++++ K+++ +E+E+E
Sbjct: 1055 ERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESD 1114
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 185
+ ++ K PV K + + E + K + G ++ K
Sbjct: 1115 DADDTPILK-PVSLL---------RKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWK 1164
Query: 186 EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSP 245
+ G + K +++ S + E +V+ K + K K +
Sbjct: 1165 KR------------PGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR--KPKIQESEET 1210
Query: 246 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
VE K P+P EE+ + ++ EE E+G+ E+ A S
Sbjct: 1211 VEPKEDMPLP----EERKEEEEMQAEAEE-----------AEEGEE-------EDAASSE 1248
Query: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365
VP + ++ + E E + EEE+E +E++ ++E++ + PE ++ E E
Sbjct: 1249 VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
Query: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 425
A + HLE K+E L+++ +E E G +E D + SR+
Sbjct: 1309 AQNDDHDADDEDDGHLESTKKKE---LEEQPTREDVKEEPGVQESFLDANMQKSRE---- 1361
Query: 426 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI 485
+++ KEE E +++E+ + VV+ + S D ++ EE ++ K E+I
Sbjct: 1362 ---KIKDKEETELDSEEEQP--SHDTSVVSEQMAGSEDDHEEDSHTKEE-LIELKEEEEI 1415
Query: 486 TSEGGDGATKYITKSVTVTQKVEEHEETF---EEKLVSTKKVEKVT 528
D T +S+T ++ EHE + EE L + + ++ T
Sbjct: 1416 PHSELDLETVQAVQSLT-QEESSEHEGAYQDCEETLAACQTLQSYT 1460
Score = 54.3 bits (129), Expect = 3e-07
Identities = 112/509 (22%), Positives = 188/509 (36%), Gaps = 131/509 (25%)
Query: 98 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 157
T + +V +EE++EA E + EEP+ +E E+ + S K+ + E KE++ E E +
Sbjct: 777 TPVIVSNSVVSEEEEEEAEEGENEEPQCQEREL--EISVGKSVSHENKEQDSYSVESEKK 834
Query: 158 EE--------------------------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 191
E G K+ + +E +K+ EE
Sbjct: 835 PEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSA 894
Query: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA--------KSPVPK 243
E E GE++EA +E+ E + + VA++E+ D K + P++ + + K
Sbjct: 895 PQEQYGEC-GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKK 953
Query: 244 SPVEEK-----GKSPVPK----------------SPVEEKGKSPVPKSP-----VEEKGK 277
SP K G +P+ S EE+ +SP SP K K
Sbjct: 954 SPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRK 1013
Query: 278 SPVPKSPVEEKGKSPVSKSPVEE--KAKSPVPKSPVEEAKSKAEVGKGE------QKEEE 329
P + + + S V E + V P E++ S+ + + E ++EEE
Sbjct: 1014 KPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEE 1073
Query: 330 EKEVKEAPKE-------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 382
E E + P+E + V + + K K K E +E A+ I K V + +
Sbjct: 1074 EDENELFPREYFRRLSSQDVLRCQSSSK---RKSKDEEEDEESDDADDTPILKPVSLLRK 1130
Query: 383 KETKEEGKPLQQEKE---KEKAGGEGGSEEE--------GSDKGAKGSR----------- 420
++ K PL+ + K+K G G + G G K SR
Sbjct: 1131 RDVK--NSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACV 1188
Query: 421 -------------------------KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455
KED+ + E + +EE++ E +E G EEE +
Sbjct: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEG-EEEDAASS 1247
Query: 456 NGLDLSPADEKKGGDKSEEKVVVTKTVEK 484
SPAD + ++ V + EK
Sbjct: 1248 EVPAASPADSSNSPETETKEPEVEEEEEK 1276
Score = 35.8 bits (81), Expect = 0.10
Identities = 58/275 (21%), Positives = 104/275 (37%), Gaps = 23/275 (8%)
Query: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG-AKSDQAEEGGSEKE 180
+PE + V + E + EEGE EE + QE E E G + S + +E S
Sbjct: 770 DPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSV 829
Query: 181 GSSEKEEGEQEEGETEAEA-----EGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKP 234
S +K E T + A ++ ++ + T+E D+K+
Sbjct: 830 ESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLE 889
Query: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK---SPVEEKGKS 291
E + +P + + + E + + + + GK +PK S E +
Sbjct: 890 ETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
Query: 292 PVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE------KVE 343
+ KSP K + + P ++ V +G + EE+E E+P+ K
Sbjct: 950 QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
Query: 344 KKEEKP-----KDVPEKKKAESPVKEEAVAEVVTI 373
K +KP + V ++K S V E ++E +
Sbjct: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEV 1044
Score = 32.0 bits (71), Expect = 1.5
Identities = 51/233 (21%), Positives = 86/233 (36%), Gaps = 36/233 (15%)
Query: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE---------- 124
K +EE V++E E L A ++ +K++++ + +EE+P
Sbjct: 1330 KELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQM 1389
Query: 125 AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 184
A E+ + S K E+KE EEE E + E A +E SE EG+ +
Sbjct: 1390 AGSEDDHEEDSHTKEELIELKE-----EEEIPHSELDLETVQAVQSLTQEESSEHEGAYQ 1444
Query: 185 KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244
+ EE + +A E+ ++ +V D + S V
Sbjct: 1445 ----DCEETLAACQTLQSYTQADEDPQM-----------SMVEDCHASEHNSPISSVQSH 1489
Query: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297
P + P P E G + + SP E+G P ++ SP+ P
Sbjct: 1490 PSQSVRSVSSPNVPALESGYTQI--SP--EQGSLSAPS--MQNMETSPMMDVP 1536
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 86.7 bits (213), Expect = 5e-17
Identities = 105/455 (23%), Positives = 185/455 (40%), Gaps = 41/455 (9%)
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEG 166
EE++E + P + +K P V++ + E E E DE
Sbjct: 989 EEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEP 1048
Query: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE--------AEGEEAEAKEEKKVEEKSEE 218
+ +E E + E +E E+EE E E + + + K + K EE
Sbjct: 1049 FEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEE 1108
Query: 219 VATKEELVADAKVEKPEKA--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 276
+ + D + KP K V SP+E +P+ K KGKS P + G
Sbjct: 1109 EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
Query: 277 KSPVPK-----SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 331
+ P K PV + + + + P + E + K ++ E+++EEE+
Sbjct: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEE 1228
Query: 332 EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391
EA + E+ E+++ +VP A+S E T TK +V E+E K
Sbjct: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE------TETKEPEVE-EEEEKPRVSE 1281
Query: 392 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG-------KEEVEQETKEKG 444
Q++ E+E+ E EE D A+ ++ +D + E +G KE EQ T+E
Sbjct: 1282 EQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRE-- 1339
Query: 445 SGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVT 504
+EE GV + LD A+ +K +K ++K +T E T +++ + +
Sbjct: 1340 -DVKEEPGVQESFLD---ANMQKSREKIKDK---EETELDSEEEQPSHDTSVVSEQMAGS 1392
Query: 505 QKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 539
+ E + +E+L+ K+ E++ + E Q+
Sbjct: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQA 1427
Score = 68.2 bits (165), Expect = 2e-11
Identities = 64/276 (23%), Positives = 120/276 (43%), Gaps = 45/276 (16%)
Query: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
P ++I +KPK++ + V+ K E+ + +E+ E EE M+ E
Sbjct: 1191 PIVSIPKAGRKPKIQESEETVEPK------EDMPLPEERKEEEE------------MQAE 1232
Query: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ--------EEEEEE 163
+EA E +EE+ + E A+ + E KE E E+EEE+ + EEE++E
Sbjct: 1233 AEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE 1292
Query: 164 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA------EAEGEEAEAKEEKKVEE--- 214
E + ++ E+ +E + + + ++++G E+ E + + KEE V+E
Sbjct: 1293 LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFL 1352
Query: 215 ------KSEEVATKEELVADAKVEKPEKAKSPVPK----SPVEEKGKSPVPKSPVEEKGK 264
E++ KEE D++ E+P S V + S + + S + +E K +
Sbjct: 1353 DANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEE 1412
Query: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
+P S ++ + V EE + + EE
Sbjct: 1413 EEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEE 1448
Score = 65.1 bits (157), Expect = 2e-10
Identities = 95/466 (20%), Positives = 187/466 (40%), Gaps = 63/466 (13%)
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA 125
E P +++ F + EE + E+E E ++++ K+++ +E+E+E
Sbjct: 1055 ERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESD 1114
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 185
+ ++ K PV K + + E + K + G ++ K
Sbjct: 1115 DADDTPILK-PVSLL---------RKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWK 1164
Query: 186 EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSP 245
+ G + K +++ S + E +V+ K + K K +
Sbjct: 1165 KR------------PGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR--KPKIQESEET 1210
Query: 246 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
VE K P+P EE+ + ++ EE E+G+ E+ A S
Sbjct: 1211 VEPKEDMPLP----EERKEEEEMQAEAEE-----------AEEGEE-------EDAASSE 1248
Query: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365
VP + ++ + E E + EEE+E +E++ ++E++ + PE ++ E E
Sbjct: 1249 VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
Query: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 425
A + HLE K+E L+++ +E E G +E D + SR+
Sbjct: 1309 AQNDDHDADDEDDGHLESTKKKE---LEEQPTREDVKEEPGVQESFLDANMQKSRE---- 1361
Query: 426 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI 485
+++ KEE E +++E+ + VV+ + S D ++ EE ++ K E+I
Sbjct: 1362 ---KIKDKEETELDSEEEQP--SHDTSVVSEQMAGSEDDHEEDSHTKEE-LIELKEEEEI 1415
Query: 486 TSEGGDGATKYITKSVTVTQKVEEHEETF---EEKLVSTKKVEKVT 528
D T +S+T ++ EHE + EE L + + ++ T
Sbjct: 1416 PHSELDLETVQAVQSLT-QEESSEHEGAYQDCEETLAACQTLQSYT 1460
Score = 54.3 bits (129), Expect = 3e-07
Identities = 112/509 (22%), Positives = 188/509 (36%), Gaps = 131/509 (25%)
Query: 98 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 157
T + +V +EE++EA E + EEP+ +E E+ + S K+ + E KE++ E E +
Sbjct: 777 TPVIVSNSVVSEEEEEEAEEGENEEPQCQEREL--EISVGKSVSHENKEQDSYSVESEKK 834
Query: 158 EE--------------------------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 191
E G K+ + +E +K+ EE
Sbjct: 835 PEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSA 894
Query: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA--------KSPVPK 243
E E GE++EA +E+ E + + VA++E+ D K + P++ + + K
Sbjct: 895 PQEQYGEC-GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKK 953
Query: 244 SPVEEK-----GKSPVPK----------------SPVEEKGKSPVPKSP-----VEEKGK 277
SP K G +P+ S EE+ +SP SP K K
Sbjct: 954 SPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRK 1013
Query: 278 SPVPKSPVEEKGKSPVSKSPVEE--KAKSPVPKSPVEEAKSKAEVGKGE------QKEEE 329
P + + + S V E + V P E++ S+ + + E ++EEE
Sbjct: 1014 KPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEE 1073
Query: 330 EKEVKEAPKE-------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 382
E E + P+E + V + + K K K E +E A+ I K V + +
Sbjct: 1074 EDENELFPREYFRRLSSQDVLRCQSSSK---RKSKDEEEDEESDDADDTPILKPVSLLRK 1130
Query: 383 KETKEEGKPLQQEKE---KEKAGGEGGSEEE--------GSDKGAKGSR----------- 420
++ K PL+ + K+K G G + G G K SR
Sbjct: 1131 RDVK--NSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACV 1188
Query: 421 -------------------------KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455
KED+ + E + +EE++ E +E G EEE +
Sbjct: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEG-EEEDAASS 1247
Query: 456 NGLDLSPADEKKGGDKSEEKVVVTKTVEK 484
SPAD + ++ V + EK
Sbjct: 1248 EVPAASPADSSNSPETETKEPEVEEEEEK 1276
Score = 35.8 bits (81), Expect = 0.10
Identities = 58/275 (21%), Positives = 104/275 (37%), Gaps = 23/275 (8%)
Query: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG-AKSDQAEEGGSEKE 180
+PE + V + E + EEGE EE + QE E E G + S + +E S
Sbjct: 770 DPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSV 829
Query: 181 GSSEKEEGEQEEGETEAEA-----EGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKP 234
S +K E T + A ++ ++ + T+E D+K+
Sbjct: 830 ESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLE 889
Query: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK---SPVEEKGKS 291
E + +P + + + E + + + + GK +PK S E +
Sbjct: 890 ETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
Query: 292 PVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE------KVE 343
+ KSP K + + P ++ V +G + EE+E E+P+ K
Sbjct: 950 QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
Query: 344 KKEEKP-----KDVPEKKKAESPVKEEAVAEVVTI 373
K +KP + V ++K S V E ++E +
Sbjct: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEV 1044
Score = 32.0 bits (71), Expect = 1.5
Identities = 51/233 (21%), Positives = 86/233 (36%), Gaps = 36/233 (15%)
Query: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE---------- 124
K +EE V++E E L A ++ +K++++ + +EE+P
Sbjct: 1330 KELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQM 1389
Query: 125 AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 184
A E+ + S K E+KE EEE E + E A +E SE EG+ +
Sbjct: 1390 AGSEDDHEEDSHTKEELIELKE-----EEEIPHSELDLETVQAVQSLTQEESSEHEGAYQ 1444
Query: 185 KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244
+ EE + +A E+ ++ +V D + S V
Sbjct: 1445 ----DCEETLAACQTLQSYTQADEDPQM-----------SMVEDCHASEHNSPISSVQSH 1489
Query: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297
P + P P E G + + SP E+G P ++ SP+ P
Sbjct: 1490 PSQSVRSVSSPNVPALESGYTQI--SP--EQGSLSAPS--MQNMETSPMMDVP 1536
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 86.7 bits (213), Expect = 5e-17
Identities = 105/455 (23%), Positives = 185/455 (40%), Gaps = 41/455 (9%)
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE---EEGQEEEEEEDEG 166
EE++E + P + +K P V++ + E E E DE
Sbjct: 989 EEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEP 1048
Query: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE--------AEGEEAEAKEEKKVEEKSEE 218
+ +E E + E +E E+EE E E + + + K + K EE
Sbjct: 1049 FEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEE 1108
Query: 219 VATKEELVADAKVEKPEKA--KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 276
+ + D + KP K V SP+E +P+ K KGKS P + G
Sbjct: 1109 EDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPG 1168
Query: 277 KSPVPK-----SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 331
+ P K PV + + + + P + E + K ++ E+++EEE+
Sbjct: 1169 RKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEE 1228
Query: 332 EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391
EA + E+ E+++ +VP A+S E T TK +V E+E K
Sbjct: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPE------TETKEPEVE-EEEEKPRVSE 1281
Query: 392 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG-------KEEVEQETKEKG 444
Q++ E+E+ E EE D A+ ++ +D + E +G KE EQ T+E
Sbjct: 1282 EQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTRE-- 1339
Query: 445 SGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVT 504
+EE GV + LD A+ +K +K ++K +T E T +++ + +
Sbjct: 1340 -DVKEEPGVQESFLD---ANMQKSREKIKDK---EETELDSEEEQPSHDTSVVSEQMAGS 1392
Query: 505 QKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQS 539
+ E + +E+L+ K+ E++ + E Q+
Sbjct: 1393 EDDHEEDSHTKEELIELKEEEEIPHSELDLETVQA 1427
Score = 68.2 bits (165), Expect = 2e-11
Identities = 64/276 (23%), Positives = 120/276 (43%), Gaps = 45/276 (16%)
Query: 52 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 111
P ++I +KPK++ + V+ K E+ + +E+ E EE M+ E
Sbjct: 1191 PIVSIPKAGRKPKIQESEETVEPK------EDMPLPEERKEEEE------------MQAE 1232
Query: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ--------EEEEEE 163
+EA E +EE+ + E A+ + E KE E E+EEE+ + EEE++E
Sbjct: 1233 AEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE 1292
Query: 164 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA------EAEGEEAEAKEEKKVEE--- 214
E + ++ E+ +E + + + ++++G E+ E + + KEE V+E
Sbjct: 1293 LEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFL 1352
Query: 215 ------KSEEVATKEELVADAKVEKPEKAKSPVPK----SPVEEKGKSPVPKSPVEEKGK 264
E++ KEE D++ E+P S V + S + + S + +E K +
Sbjct: 1353 DANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEE 1412
Query: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
+P S ++ + V EE + + EE
Sbjct: 1413 EEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEE 1448
Score = 65.1 bits (157), Expect = 2e-10
Identities = 95/466 (20%), Positives = 187/466 (40%), Gaps = 63/466 (13%)
Query: 66 EAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA 125
E P +++ F + EE + E+E E ++++ K+++ +E+E+E
Sbjct: 1055 ERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESD 1114
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 185
+ ++ K PV K + + E + K + G ++ K
Sbjct: 1115 DADDTPILK-PVSLL---------RKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWK 1164
Query: 186 EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSP 245
+ G + K +++ S + E +V+ K + K K +
Sbjct: 1165 KR------------PGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGR--KPKIQESEET 1210
Query: 246 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
VE K P+P EE+ + ++ EE E+G+ E+ A S
Sbjct: 1211 VEPKEDMPLP----EERKEEEEMQAEAEE-----------AEEGEE-------EDAASSE 1248
Query: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365
VP + ++ + E E + EEE+E +E++ ++E++ + PE ++ E E
Sbjct: 1249 VPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAET 1308
Query: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 425
A + HLE K+E L+++ +E E G +E D + SR+
Sbjct: 1309 AQNDDHDADDEDDGHLESTKKKE---LEEQPTREDVKEEPGVQESFLDANMQKSRE---- 1361
Query: 426 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI 485
+++ KEE E +++E+ + VV+ + S D ++ EE ++ K E+I
Sbjct: 1362 ---KIKDKEETELDSEEEQP--SHDTSVVSEQMAGSEDDHEEDSHTKEE-LIELKEEEEI 1415
Query: 486 TSEGGDGATKYITKSVTVTQKVEEHEETF---EEKLVSTKKVEKVT 528
D T +S+T ++ EHE + EE L + + ++ T
Sbjct: 1416 PHSELDLETVQAVQSLT-QEESSEHEGAYQDCEETLAACQTLQSYT 1460
Score = 54.3 bits (129), Expect = 3e-07
Identities = 112/509 (22%), Positives = 188/509 (36%), Gaps = 131/509 (25%)
Query: 98 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 157
T + +V +EE++EA E + EEP+ +E E+ + S K+ + E KE++ E E +
Sbjct: 777 TPVIVSNSVVSEEEEEEAEEGENEEPQCQEREL--EISVGKSVSHENKEQDSYSVESEKK 834
Query: 158 EE--------------------------EEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE 191
E G K+ + +E +K+ EE
Sbjct: 835 PEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSA 894
Query: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA--------KSPVPK 243
E E GE++EA +E+ E + + VA++E+ D K + P++ + + K
Sbjct: 895 PQEQYGEC-GEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKK 953
Query: 244 SPVEEK-----GKSPVPK----------------SPVEEKGKSPVPKSP-----VEEKGK 277
SP K G +P+ S EE+ +SP SP K K
Sbjct: 954 SPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRK 1013
Query: 278 SPVPKSPVEEKGKSPVSKSPVEE--KAKSPVPKSPVEEAKSKAEVGKGE------QKEEE 329
P + + + S V E + V P E++ S+ + + E ++EEE
Sbjct: 1014 KPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEE 1073
Query: 330 EKEVKEAPKE-------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE 382
E E + P+E + V + + K K K E +E A+ I K V + +
Sbjct: 1074 EDENELFPREYFRRLSSQDVLRCQSSSK---RKSKDEEEDEESDDADDTPILKPVSLLRK 1130
Query: 383 KETKEEGKPLQQEKE---KEKAGGEGGSEEE--------GSDKGAKGSR----------- 420
++ K PL+ + K+K G G + G G K SR
Sbjct: 1131 RDVK--NSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACV 1188
Query: 421 -------------------------KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455
KED+ + E + +EE++ E +E G EEE +
Sbjct: 1189 IEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEG-EEEDAASS 1247
Query: 456 NGLDLSPADEKKGGDKSEEKVVVTKTVEK 484
SPAD + ++ V + EK
Sbjct: 1248 EVPAASPADSSNSPETETKEPEVEEEEEK 1276
Score = 35.8 bits (81), Expect = 0.10
Identities = 58/275 (21%), Positives = 104/275 (37%), Gaps = 23/275 (8%)
Query: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG-AKSDQAEEGGSEKE 180
+PE + V + E + EEGE EE + QE E E G + S + +E S
Sbjct: 770 DPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSV 829
Query: 181 GSSEKEEGEQEEGETEAEA-----EGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKP 234
S +K E T + A ++ ++ + T+E D+K+
Sbjct: 830 ESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLE 889
Query: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK---SPVEEKGKS 291
E + +P + + + E + + + + GK +PK S E +
Sbjct: 890 ETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRG 949
Query: 292 PVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEE------KVE 343
+ KSP K + + P ++ V +G + EE+E E+P+ K
Sbjct: 950 QLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPT 1009
Query: 344 KKEEKP-----KDVPEKKKAESPVKEEAVAEVVTI 373
K +KP + V ++K S V E ++E +
Sbjct: 1010 LKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEV 1044
Score = 32.0 bits (71), Expect = 1.5
Identities = 51/233 (21%), Positives = 86/233 (36%), Gaps = 36/233 (15%)
Query: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE---------- 124
K +EE V++E E L A ++ +K++++ + +EE+P
Sbjct: 1330 KELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQM 1389
Query: 125 AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSE 184
A E+ + S K E+KE EEE E + E A +E SE EG+ +
Sbjct: 1390 AGSEDDHEEDSHTKEELIELKE-----EEEIPHSELDLETVQAVQSLTQEESSEHEGAYQ 1444
Query: 185 KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244
+ EE + +A E+ ++ +V D + S V
Sbjct: 1445 ----DCEETLAACQTLQSYTQADEDPQM-----------SMVEDCHASEHNSPISSVQSH 1489
Query: 245 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297
P + P P E G + + SP E+G P ++ SP+ P
Sbjct: 1490 PSQSVRSVSSPNVPALESGYTQI--SP--EQGSLSAPS--MQNMETSPMMDVP 1536
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 86.3 bits (212), Expect = 7e-17
Identities = 103/406 (25%), Positives = 198/406 (48%), Gaps = 28/406 (6%)
Query: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 115
I + +K + + K++ Q + + E E+ + ++E +E EE+ KEEK
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE-KEEKMRR 381
Query: 116 AEE---KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172
EE ++EE E EE ++ ++ ++EE +EEE+ +E+E+ +++ AK +
Sbjct: 382 QEEMMWEKEEKIRELEEKMHEQEKIR------EQEEKRQEEEKIREQEKRQEQEAKMWRQ 435
Query: 173 EEGGSEKE---GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA 229
EE E+E EK+ QEE E E EE + +E++++ + E++ +EE+
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW--R 493
Query: 230 KVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 289
+ EK + + + K E+ + EEK + K +E+ + EE+
Sbjct: 494 QKEKMHEQEEKIRKQE-EKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 290 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE--EKEVKEAPKEEKVEKKEE 347
K EEK + K +E K + + K ++EE+ E+E K +EEK+ K+EE
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE 612
Query: 348 KPKDVPEK-KKAESPVK--EEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
K ++ EK ++ E ++ EE + E +T+ + EK ++E K +QE++ ++
Sbjct: 613 KIREQEEKIQEQEEKIREQEEKIREQEEMTQEQE---EKMGEQEEKMCEQEEKMQEQEET 669
Query: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
+EE + K R+++ ++ +EE+ QE +EK +EE+
Sbjct: 670 MWRQEEKIREQEKKIREQE----EKIREQEEMMQEQEEKMWEQEEK 711
Score = 82.8 bits (203), Expect = 7e-16
Identities = 115/508 (22%), Positives = 222/508 (43%), Gaps = 69/508 (13%)
Query: 73 QHKFVEEIIEETKVEDEKSEMEEALTAITE----------------------ELAVSMKE 110
Q K + IEE E + +E IT+ E+ +++KE
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 111 EKKEAAEEK----EEEPEAEEEEVAAKKSPVKA-TAPEVKEEE-----GEKEEEEGQEEE 160
K++ K +++ +AE + + + V A +V+E E +++EE+ +E
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 306
Query: 161 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 220
E+ E + Q +E ++ +E+ E+ + E E EE ++E+ + EK E++
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 221 TKEELVADAKV----------EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
+EE++ + + EK EK + K +EK + K EEK + +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 271 PVEEKGKSPVPK-SPVEEKGKSPVSKS-PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE 328
E K K EEK + K EEK E+ + + E+ + E+K
Sbjct: 427 EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH 486
Query: 329 EEKEV-----KEAPKEEKVEKKEEKPKDVPEK-KKAESPVKEEAV---AEVVTITKSVKV 379
E++E+ K +EEK+ K+EEK EK ++ E ++E+ + I + ++
Sbjct: 487 EQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM 546
Query: 380 HLEKE-TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQ 438
E+E E+ K ++EK +E+ EE+ ++ K R+E+ E + +E+ E+
Sbjct: 547 WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606
Query: 439 ETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYIT 498
K++ RE+E+ + ++++ + EEK+ + E++T E + +
Sbjct: 607 MWKQEEKIREQEEKI---------QEQEEKIREQEEKI---REQEEMTQEQEEKMGEQEE 654
Query: 499 KSVTVTQKVEEHEETF---EEKLVSTKK 523
K +K++E EET EEK+ +K
Sbjct: 655 KMCEQEEKMQEQEETMWRQEEKIREQEK 682
Score = 82.0 bits (201), Expect = 1e-15
Identities = 101/492 (20%), Positives = 224/492 (45%), Gaps = 34/492 (6%)
Query: 56 ISSKIQKPKVEAPKLKVQH------KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMK 109
+ K+++ K+ P+ ++Q K ++ + + + + E++E+ L EE +
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 306
Query: 110 E---EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG----------EKEEEEG 156
E E +E +E+EE+ +EE++ ++ ++ + E+E EKEE+
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 157 QEEE---EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE 213
++EE E+E++ + ++ EK E++ EQE+ + E EE + +E++K +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 214 EKSEEVATKEELVADAKV---EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 270
E+ ++ +EE + + + E+ +K K +EK + + EE +
Sbjct: 427 EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH 486
Query: 271 PVEEKGKSPVPKSPVEEKGKSPVSKS-PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 329
EE + EEK + K EEK + K +E K + K ++EE
Sbjct: 487 EQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM 546
Query: 330 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389
+E ++ ++EK+ ++E++ + + + E ++E+ +V + ++ EK ++E
Sbjct: 547 WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE-EKVWRQEEKIREQEEKRQEQEE 605
Query: 390 KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREE 449
K +QE++ + + +EE + + R+++ + E E E++ E+ +E
Sbjct: 606 KMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 450 EKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEE 509
++ + + EKK ++ EEK+ + E++ E + + K +K++E
Sbjct: 666 QEETMWRQEEKIREQEKKIREQ-EEKI---REQEEMMQEQEEKMWEQEEKMCEQEEKMQE 721
Query: 510 HEETF---EEKL 518
EE EEK+
Sbjct: 722 QEEKMRRQEEKM 733
Score = 82.0 bits (201), Expect = 1e-15
Identities = 90/366 (24%), Positives = 170/366 (46%), Gaps = 23/366 (6%)
Query: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE-VAAKKSPVKA 139
+EE E EK +E E++ K +++EA ++EE E+EE + ++ +
Sbjct: 396 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 455
Query: 140 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA 199
++ E+E +EEE+ QE+EE + K + EE +KE E+EE +++ E
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515
Query: 200 EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV 259
E E ++E+K+ E+ E++ +EE + + + E+ K + EE+ +
Sbjct: 516 E--EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 260 EEKGKSPVPKSPV---EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 316
++ K + V EEK + K +E+ EEK + K +E K
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEE-----KMWKQEEKIREQEEKIQEQEEKI 628
Query: 317 KAEVGKGEQKEE--EEKEVKEAPKEEKVEKKEEKPKDVPEKK-KAESPVKEEAVAEVVTI 373
+ + K ++EE +E+E K +EEK+ ++EEK ++ E + E ++E+
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQ-------- 680
Query: 374 TKSVKVHLEK-ETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEG 432
K ++ EK +EE Q+EK E+ EE+ ++ K R+E+ EV
Sbjct: 681 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 433 KEEVEQ 438
+++ E+
Sbjct: 741 RQQEEK 746
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/337 (22%), Positives = 168/337 (49%), Gaps = 19/337 (5%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-- 118
+K + + K+ Q + + E +E K+ +++ +M I E+ + +EEK++ EE
Sbjct: 423 EKRQEQEAKMWRQEEKIRE--QEEKIREQEKKMWRQEEKIHEQEKIR-EEEKRQEQEEMW 479
Query: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGE--KEEEEGQEEEEE--EDEGAKSDQAEE 174
++EE E+EE+ +K + +++++E + ++EE+ +E+EE+ E E Q E+
Sbjct: 480 RQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK 539
Query: 175 GGSEKEGSSEKEEGEQEEG--ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 232
++E E+E+ ++E E E E E+ ++E+K+ E+ E+V +EE + + + +
Sbjct: 540 IREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK 599
Query: 233 KPEKAKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS 291
+ E+ + + EEK + K EEK + K +E+ + + E+ G+
Sbjct: 600 RQEQEEKMWKQ---EEKIREQEEKIQEQEEKIREQEEKIREQEE----MTQEQEEKMGEQ 652
Query: 292 PVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351
EEK + +E K + + K ++EE+ +E +E +E++ + E++ K
Sbjct: 653 EEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712
Query: 352 VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE 388
+++K + ++ E + V++ ++E +E
Sbjct: 713 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 65.9 bits (159), Expect = 9e-11
Identities = 49/202 (24%), Positives = 102/202 (50%), Gaps = 23/202 (11%)
Query: 50 HRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMK 109
H I + +K + K++ Q + + E E+ ++EK +E + E++ K
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEE-----------GQE 158
++E +E+E++ +EE++ ++ V +++E+E +++E+E QE
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 159 EEEEEDEGAKSDQAEEGGSEKEGSSEKEE--GEQEEGETEAEAEGEEAE----------A 206
E+ +E E +Q E+ ++E + E+EE GEQEE E E + +E E
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 207 KEEKKVEEKSEEVATKEELVAD 228
++EKK+ E+ E++ +EE++ +
Sbjct: 679 EQEKKIREQEEKIREQEEMMQE 700
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 86.3 bits (212), Expect = 7e-17
Identities = 101/461 (21%), Positives = 211/461 (45%), Gaps = 35/461 (7%)
Query: 81 IEETKVEDEKSEMEEALTAITEE---LAVSMKEEKKEAAEEK----EEEPEAEEEEVAAK 133
I + +++++ ++++E L + E + +++KE K++ K +++ +AE + + +
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 134 KSPVKATAP-EVKEEE-----GEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187
V A +V+E E +++EE+ +EE+ E + Q +E ++ +E+
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 247
E+ + E E EE ++E+ + EK E++ EE++ EK EK + K +
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW----EKEEKIRELEEKMHEQ 389
Query: 248 EKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK-SPVEEKGKSPVSKS-PVEEKAKSP 305
EK + K EEK + + E K K EEK + K EEK
Sbjct: 390 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEV----KEAPKEEKVEKKEEKPKDVPEKKKAESP 361
E+ + + E+ + E+K E++E+ ++ ++EK+ K+EEK EK +
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEE 509
Query: 362 VKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 421
E ++ + ++ EK ++E K +QE+ ++ + G +EE + K R+
Sbjct: 510 KIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQ 569
Query: 422 EDIAVNGEVEGKEEVEQETKEKGSGRE----EEKGVVTNGLDLSPADEKKGGDKSEEKVV 477
E+ ++ +EE +E KEK +E E++ + ++ E+K ++ E+
Sbjct: 570 EE-----KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624
Query: 478 VTKTVEKITSEGGDGATKYITKSVTVTQ---KVEEHEETFE 515
+ +++ + K + V + Q K++EH+E E
Sbjct: 625 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 77.4 bits (189), Expect = 3e-14
Identities = 90/383 (23%), Positives = 177/383 (46%), Gaps = 54/383 (14%)
Query: 69 KLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE---EKKEAAEEKEEEPEA 125
K++ Q + + E E+ + ++EK +E + EE +E EK+E EE
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWE 374
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEK 185
+EE++ + + ++EE +EEE+ +E+E+ +++ AK + EE E+E +
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434
Query: 186 EEG----------EQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
+E EQE+ E + + +E ++E+K+ E+ EE+ ++E K+ + E
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ-EEIWRQKE-----KMHEQE 488
Query: 236 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 295
K + K +E+ + E++ K + + E+ EEK +
Sbjct: 489 KIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ----------EEKIREQ--- 535
Query: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK 355
EEK + EE + E GEQ+E+ +++ K +EEK+ ++EEK ++ EK
Sbjct: 536 ---EEKIREQ------EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG 415
+ + EE + E + K+ ++E +E Q+EK E+ EE+ ++
Sbjct: 587 IREQ----EEKIWE-----QEEKIREQEEMMQE----QEEKMWEQEEKMCEQEEKMQEQE 633
Query: 416 AKGSRKEDIAVNGEVEGKEEVEQ 438
K R+E+ EV +++ E+
Sbjct: 634 EKMRRQEEKMWEQEVRLRQQEEK 656
Score = 70.5 bits (171), Expect = 4e-12
Identities = 69/293 (23%), Positives = 140/293 (47%), Gaps = 12/293 (4%)
Query: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE-VAAKKSPVKA 139
+EE E EK +E E++ K +++EA ++EE E+EE + ++ +
Sbjct: 382 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 441
Query: 140 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA 199
++ E+E +EEE+ QE+EE + K + EE +KE E+E+ ++E + +
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ- 500
Query: 200 EGEEAEAKEEKKVEEKSEEVATKEELVADA--KVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
EE +E+K+ E+ E++ +EE + + K+ + E+ + E++ K +
Sbjct: 501 --EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEE 558
Query: 258 PVEEKGKSPVPKSPV-EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 316
++E+ K + + E++ K K + E+ + + EEK + +E K
Sbjct: 559 KMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ---EEKIREQEEMMQEQEEKM 615
Query: 317 KAEVGKGEQKEE--EEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
+ K ++EE +E+E K +EEK+ ++E + + EK + E A+
Sbjct: 616 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 69.7 bits (169), Expect = 6e-12
Identities = 81/350 (23%), Positives = 160/350 (45%), Gaps = 18/350 (5%)
Query: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKS-EMEEALTAITEELAVSMKEEKKE 114
I + +K + + K++ Q + + E E+ + ++E E EE + + E + KEEK
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWE--KEEKIR 380
Query: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKE-EEEGQEEEEEEDEGAKSDQAE 173
EEK E E E+ ++ K E ++E+ K +E + E+EE K + E
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE----KIREQE 436
Query: 174 EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK 233
+K E++ EQE+ E + + +E ++E+K+ E+ E KE++ K+ K
Sbjct: 437 ----KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Query: 234 PEKA--KSPVPKSPVEEKGKSPVPKS-PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
E+ + EEK + K EEK + K +E+ + E++ K
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEK 552
Query: 291 SPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK 350
+ ++E+ K + + E + K K + +E+EEK ++ EEK+ ++EE +
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ---EEKIREQEEMMQ 609
Query: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 400
+ EK + E ++ + ++ EK ++E + QQE++ ++
Sbjct: 610 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 60.1 bits (144), Expect = 5e-09
Identities = 71/295 (24%), Positives = 141/295 (47%), Gaps = 28/295 (9%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK- 119
++ K+ + K Q + E+I E+ K ++++++M I E+ ++EKK +E+
Sbjct: 388 EQEKIREQEEKRQEE--EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445
Query: 120 --EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS 177
E+E EEE+ ++ ++EE +E+EE ++E+ E K + E
Sbjct: 446 IHEQEKIREEEKRQEQEE-------MWRQEEKIREQEEIWRQKEKMHEQEKIRKQE---- 494
Query: 178 EKEGSSEKEEGEQEEGETEAEAE---GEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
EK E++ +QEE E E + EE ++E+K+ E+ E++ +EE++ E+
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ----EQE 550
Query: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVS 294
EK K +EK + K +E+ + E++ K + + E+ +
Sbjct: 551 EKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Query: 295 KSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE--EKEVKEAPKEEKVEKKEE 347
+ EEK K +E K + + K ++EE+ E+EV+ +EEK+++ +E
Sbjct: 611 Q---EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 52.0 bits (123), Expect = 1e-06
Identities = 45/169 (26%), Positives = 87/169 (51%), Gaps = 14/169 (8%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITE-ELAVSMKEEKKEAAEEK 119
Q+ K+ + K++ + + +E K+ +++ ++ E I E E + +EEK EEK
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 120 EEEPEA---EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE-EEDEGAKSDQAEEG 175
+E E +EE++ ++ ++ E KE+ E+EE+ ++EE+ E E +Q E+
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIR----EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKM 615
Query: 176 GSEKEGSSEKEEGEQEEGE-----TEAEAEGEEAEAKEEKKVEEKSEEV 219
++E E+EE QE+ E E E E ++E+K++E E +
Sbjct: 616 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/148 (24%), Positives = 81/148 (54%), Gaps = 10/148 (6%)
Query: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK--- 112
I + +K + + K++ Q + ++E +E K+ +++ +M+E +E + +EEK
Sbjct: 525 IREQEEKIREQEEKIREQEEMMQE--QEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582
Query: 113 -KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
KE E+EE+ +EE++ ++ ++ E +E+ E+EE+ ++EE+ +++ K +
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEMMQ----EQEEKMWEQEEKMCEQEEKMQEQEEKMRR 638
Query: 172 AEEGGSEKEGSSEKEEGEQEEGETEAEA 199
EE E+E ++E + +E + EA
Sbjct: 639 QEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 37.4 bits (85), Expect = 0.035
Identities = 29/109 (26%), Positives = 56/109 (51%), Gaps = 7/109 (6%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK- 119
+K + + K++ Q + + E E+ + ++EK +E EE+ + +EEK EEK
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEM-MQEQEEKMWEQEEKM 622
Query: 120 -EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 167
E+E + +E+E ++ K EV+ +++EE +E +E E A
Sbjct: 623 CEQEEKMQEQEEKMRRQEEKMWEQEVRL----RQQEEKMQEHQEHLEAA 667
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 85.5 bits (210), Expect = 1e-16
Identities = 73/216 (33%), Positives = 100/216 (46%), Gaps = 9/216 (4%)
Query: 140 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA 199
T + + E+EEEE +EEEEEE+E + D EE E+E E+EE E+EE E E E
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEE-EEEEFEEEFEE 937
Query: 200 EGEEAEAKEEKKVEEKSEEVATKEEL-VADAKVEKPEKAKSPVPKSPVEEKGKSP--VPK 256
E E E +EE++ EE+ EE+ E+L A E E A P P +SP V
Sbjct: 938 EEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQP 997
Query: 257 SPVEEKGKSPVPKSP--VEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEA 314
P E G + P EE+G P E + E A P P+ VEE
Sbjct: 998 EPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEE 1057
Query: 315 KSKAEVGKGEQKEEEEKEVK---EAPKEEKVEKKEE 347
S E+ E+ +V+ E P EE++E + E
Sbjct: 1058 PSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETE 1093
Score = 76.6 bits (187), Expect = 5e-14
Identities = 77/254 (30%), Positives = 112/254 (44%), Gaps = 40/254 (15%)
Query: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 122
P +E + +E EE + E+E+ E EE EE +EE +E E+EEE
Sbjct: 872 PALEEDLTVININSSDEEEEEEEEEEEEEEEEE-----EEEEDFEEEEEDEEEYFEEEEE 926
Query: 123 PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGS 182
E E EE E +EEEGE EEEE +E+EEEE+E + + E G
Sbjct: 927 EEEEFEE-------------EFEEEEGELEEEEEEEDEEEEEELEEVEDLEFG----TAG 969
Query: 183 SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS------EEVATKEELVADAKVEKPEK 236
E EEG E+ K + + E + EE T+EE AD P
Sbjct: 970 GEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADT---APTL 1026
Query: 237 AKSPVP-KSPVEEKGKSPV----PKSPVEEKGKSPVPKSPVEEKGKS----PVPKSPVEE 287
A +P + VE +G+SP P+ VEE+ +P E + S P P++P EE
Sbjct: 1027 APEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEE 1086
Query: 288 KGKSPVSKSPVEEK 301
+ ++ ++EK
Sbjct: 1087 EMETETEAEALQEK 1100
Score = 73.2 bits (178), Expect = 6e-13
Identities = 74/275 (26%), Positives = 116/275 (42%), Gaps = 29/275 (10%)
Query: 129 EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
++ + +P P ++E+ EEEEEE+E + ++ EE E+E E+EE
Sbjct: 859 QLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEE--EEEEDFEEEEED 916
Query: 189 EQE--EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV 246
E+E E E E E E EE +EE ++EE+ EE +EE ++E+ E + V
Sbjct: 917 EEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEE----EELEEVEDLEFGTAGGEV 972
Query: 247 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
EE P P +SP P E P VEE G EE+
Sbjct: 973 EEGAPPPPTLPPALPPPESPPKVQP--EPEPEPGLLLEVEEPGTE-------EERGADTA 1023
Query: 307 PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA 366
P E S +GE + E E P +E VE++ P + E++ + K +
Sbjct: 1024 PTLAPEALPS-----QGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQP 1078
Query: 367 VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKA 401
E E ET+ E + LQ++++ + A
Sbjct: 1079 PPE-------TPAEEEMETETEAEALQEKEQDDTA 1106
Score = 59.3 bits (142), Expect = 9e-09
Identities = 56/224 (25%), Positives = 95/224 (42%), Gaps = 19/224 (8%)
Query: 54 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK 113
I I+S ++ + E + + + + EE + + E+++ E E EE +EE+
Sbjct: 881 ININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEG 940
Query: 114 EAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEG----------EKEEEEGQEEEEEE 163
E EE+EEE E EEEE+ + TA EE E + + E E
Sbjct: 941 ELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPE 1000
Query: 164 DEGAKSDQAEEGGSEKEGSSE-----KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
E + EE G+E+E ++ E +GE E E E A ++ VEE+
Sbjct: 1001 PEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSA 1060
Query: 219 VATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 262
T + + + E P P++P EE+ ++ ++EK
Sbjct: 1061 PPT----LLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEK 1100
Score = 56.2 bits (134), Expect = 7e-08
Identities = 86/351 (24%), Positives = 127/351 (36%), Gaps = 67/351 (19%)
Query: 126 EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE-------GGSE 178
E EE+ A P+ P G Q E G EE S+
Sbjct: 828 EPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSD 887
Query: 179 KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
+E E+EE E+EE E E E + EE E EE+ EE+ EE +EE + + E+ E +
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEE---EEEFEEEFEEEEGELEE 944
Query: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298
+ EE+ V G E+G P P P
Sbjct: 945 EEEEEDEEEEEELEEVEDLEFGTAGGEV-------EEGAPPPPTLP-------------- 983
Query: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
P P+SP + + + E G E EE P E+ + P PE +
Sbjct: 984 ---PALPPPESP-PKVQPEPEPEPGLLLEVEE------PGTEEERGADTAPTLAPEALPS 1033
Query: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 418
+ V+ E E+ G P Q+ E+E + EEE D G
Sbjct: 1034 QGEVEREG-----------------ESPAAGPPPQELVEEEPSAPPTLLEEETED----G 1072
Query: 419 SRKEDIAVNGEVEGKEEVEQETKEKGSGREEE---KGVVTNGLDLSPADEK 466
S K + E +EE+E ET+ + +E+ ++ + +D P DEK
Sbjct: 1073 SDK--VQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEK 1121
Score = 50.4 bits (119), Expect = 4e-06
Identities = 62/232 (26%), Positives = 97/232 (41%), Gaps = 35/232 (15%)
Query: 234 PEKAKSPVP-KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 292
P A PVP K EE +P P P P P PV G +P + +G
Sbjct: 816 PPTASPPVPAKEEPEELPAAPGPLPP------PPPPPPPVP--GPVTLPPPQLVPEGTPG 867
Query: 293 VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKEAPKEEKVEKKEEK 348
P E+ + + + +E + + E + E++EEEE+ E +E +EE E++EE+
Sbjct: 868 GGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEE 927
Query: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSE 408
++ E+ + E EE E+E EE + +E E + G GG
Sbjct: 928 EEEFEEEFEEEEGELEEE---------------EEEEDEEEEEELEEVEDLEFGTAGGEV 972
Query: 409 EEGSD-----KGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455
EEG+ A + V E E + + E +E G+ EEE+G T
Sbjct: 973 EEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGT--EEERGADT 1022
Score = 48.1 bits (113), Expect = 2e-05
Identities = 58/228 (25%), Positives = 90/228 (39%), Gaps = 31/228 (13%)
Query: 229 AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 288
AK E E +P P P P P PV P P+ E P + E+
Sbjct: 825 AKEEPEELPAAPGPLPP------PPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDL 878
Query: 289 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 348
++ S EE+ + + EE + + + + E+ EEE E +E +EE E+ EE+
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEE 938
Query: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP----------------- 391
++ E+++ E +EE + EV + ++ EEG P
Sbjct: 939 EGELEEEEEEEDEEEEEELEEV----EDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPK 994
Query: 392 LQQEKEKEKA----GGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE 435
+Q E E E E G+EEE A E + GEVE + E
Sbjct: 995 VQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGE 1042
Score = 47.8 bits (112), Expect = 3e-05
Identities = 67/241 (27%), Positives = 97/241 (40%), Gaps = 63/241 (26%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
++ + E + + + F EE +E + +E+ E EE EE ++EE++E EE+E
Sbjct: 895 EEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEE 954
Query: 121 EEPEAEEE----------EVAAKKSPVKATA-----------PEVKEEEGE--KEEEEGQ 157
EE E E+ E A P A PE + E G + EE G
Sbjct: 955 EELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGT 1014
Query: 158 EEEEEEDEG---AKSDQAEEGGSEKEGSS-----------EKE--------EGEQEEG-- 193
EEE D A +G E+EG S E+E E E E+G
Sbjct: 1015 EEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSD 1074
Query: 194 ------ETEAEAEGE---EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244
ET AE E E EAEA +EK+ ++ + ++AD P+ K P P
Sbjct: 1075 KVQPPPETPAEEEMETETEAEALQEKEQDDTA-------AMLADFIDCPPDDEKPPPPTE 1127
Query: 245 P 245
P
Sbjct: 1128 P 1128
Score = 32.0 bits (71), Expect = 1.5
Identities = 40/157 (25%), Positives = 63/157 (40%), Gaps = 22/157 (14%)
Query: 27 KLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEI---IEE 83
+L E E+ F T G + PP T+ + P+ PK++ + + + +EE
Sbjct: 956 ELEEVEDLEFGTAGGEVEEGA---PPPPTLPPALPPPE-SPPKVQPEPEPEPGLLLEVEE 1011
Query: 84 TKVEDEKSEMEEALTAITEELAVSMKEEKKEAA---------EEKEEEPEAE----EEEV 130
E+E+ + + E S E ++E E EEEP A EEE
Sbjct: 1012 PGTEEERGA--DTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEET 1069
Query: 131 AAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 167
V+ EEE E E E +E+E+D+ A
Sbjct: 1070 EDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTA 1106
Score = 30.8 bits (68), Expect = 3.3
Identities = 56/272 (20%), Positives = 94/272 (34%), Gaps = 44/272 (16%)
Query: 234 PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 293
PE ++ + P+ +P P P +E VP+ K + + S
Sbjct: 727 PENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDD 786
Query: 294 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 353
S V E P+P P A G KE P EE P P
Sbjct: 787 SVVIVPE-GLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEP-EELPAAPGPLPPPPP 844
Query: 354 EKKKAESPVK----------------EEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE 397
PV A+ E +T+ + ++ E +EE + ++E+E
Sbjct: 845 PPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTV---ININSSDEEEEEEEEEEEEEE 901
Query: 398 KEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG 457
+E+ E EEE E +EE +E +E+ EEE
Sbjct: 902 EEEEEEEDFEEEE--------------------EDEEEYFEEEEEEEEEFEEEFEEEEGE 941
Query: 458 LDLSPADEKKGGDKSEEKVVVTKTVEKITSEG 489
L+ +E++ ++ EE++ + +E T+ G
Sbjct: 942 LE---EEEEEEDEEEEEELEEVEDLEFGTAGG 970
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 85.1 bits (209), Expect = 1e-16
Identities = 89/389 (22%), Positives = 187/389 (48%), Gaps = 38/389 (9%)
Query: 6 REYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLY-THRPPITISSKIQKPK 64
R ++L + AL +E+ YR + EE + L + + I ++ K K K
Sbjct: 181 RYIEELTKERDALSLEL--YRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK 238
Query: 65 VEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK--KEAAEEKEEE 122
+E KL ++ + +++ E + + L +++ +L ++E + +++EE+
Sbjct: 239 LERAKL---------LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 289
Query: 123 PEAEEEEVAAKKSPVKATAPEVKEEEG----------EKEEEEGQEEEEEEDEGAKSDQA 172
+EE++ ++ ++ +++E+E EKEE+ ++EE ++ K +
Sbjct: 290 MWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 349
Query: 173 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK---EEKKVEEKSEEVATKEELVADA 229
EE E+E E+EE QEE + + + +E EAK +E+K+ E+ E++ +EE++ +
Sbjct: 350 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ 409
Query: 230 KVEKPEKA----KSPVPKSPVEEKGKSPVPKSPVEEKG-KSPVPKSPVEEKGKSPVPKSP 284
+ + E+ + EEK + K +EK + K +E+ +
Sbjct: 410 EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 469
Query: 285 VEEKGKSPVSKSPV---EEKAKSPVPKSPVEEAKSKAEVGKGEQKEE--EEKEVKEAPKE 339
E++GK ++ + EEK + K +E K + + K ++EE +E+E K +E
Sbjct: 470 GEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 529
Query: 340 EKVEKKEEKPKDVPEK-KKAESPVKEEAV 367
EK+ ++EEK ++ EK ++ E ++E+ V
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMREQEV 558
Score = 78.6 bits (192), Expect = 1e-14
Identities = 85/386 (22%), Positives = 181/386 (46%), Gaps = 24/386 (6%)
Query: 75 KFVEEIIEE-TKVEDEKSEMEEALTAITEEL-AVSMKEEKKEAAEEKEEEPEAEEEE--- 129
KF E+ + + V +K + + + +T+E A+S++ + +E+ +E A+ +E
Sbjct: 160 KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQ 219
Query: 130 -VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
V ++KS ++ E+K + + Q++ + E A+ G E + S K +
Sbjct: 220 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAE--------ADHLGKELQSVSAKLQA 271
Query: 189 EQEEGE--TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV 246
+ EE E + EE ++E+K++E+ E++ +EE + + E+ + + +
Sbjct: 272 QVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQ--EEKMRRQEEMMWEKE 329
Query: 247 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
E+ + EEK + K +EK + K EEK + + E K
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 307 PKSPVEEAKSKAEVGKGEQKEEE--EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKE 364
K +E K + + +++EE+ E+E K +EE+++++EEK + EK + +
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449
Query: 365 EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDI 424
E ++ + ++ EK ++EGK +QE + ++ + +EE + K R+++
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE- 508
Query: 425 AVNGEVEGKEEVEQETKEKGSGREEE 450
++ +EE+ QE +EK +EE+
Sbjct: 509 ---EKIREQEEMMQEQEEKMWEQEEK 531
Score = 77.4 bits (189), Expect = 3e-14
Identities = 89/392 (22%), Positives = 170/392 (43%), Gaps = 23/392 (5%)
Query: 73 QHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMK---EEKKEAAEEKEEEPEAEEEE 129
Q K + IEE E + +E IT+E +EK + E ++ E + +E
Sbjct: 175 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 234
Query: 130 VAAKKSPVKATAPEV----------KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
+ K K P+ KE + + + Q EE E Q E+ ++
Sbjct: 235 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE 294
Query: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
E E+EE QE+ E E E E ++E+ + EK E++ +EE++ EK EK +
Sbjct: 295 EKIQEREEKIQEQEEKIREQE--EKMRRQEEMMWEKEEKMRRQEEMMW----EKEEKIRE 348
Query: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
K +EK + K EEK + + E K K +E+ + E
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
++ K + + E + + + + + + +EEK ++E +E+K+ ++EEK ++ E + +
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK-IRE--QEKKIREQEEKIREQEEMMQEQ 465
Query: 360 SPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE-KEKAGGEGGSEEEGSDKGAKG 418
E ++ ++ EK ++E K +QEK+ +E+ EE ++ K
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 525
Query: 419 SRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
+E+ E + +E+ E+ +++ RE+E
Sbjct: 526 WEQEEKMCEQEEKMQEQEEKMRRQEEKMREQE 557
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 26/184 (14%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Q+ K+ + K++ + EE+++E E++ E EE + EE+ +EEK EEK
Sbjct: 388 QEEKIREQEEKIREQ--EEMMQEQ--EEKMGEQEEKMWEQEEEM--QEQEEKMRRQEEKI 441
Query: 121 EEPEA----EEEEVAAKKSPVKATAPEVKEEEGE--------KEEEEGQEEEEE---EDE 165
E E +EE++ ++ ++ ++ E+EG+ +E+EE +EE E E
Sbjct: 442 REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE 501
Query: 166 GAKSDQAEEGGSEKEGSSEKEE--GEQEEGETEAEAEGEEAEAK---EEKKVEEKSEEVA 220
+Q E+ ++E E+EE EQEE E E + +E E K +E+K+ E+ +
Sbjct: 502 KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR 561
Query: 221 TKEE 224
+EE
Sbjct: 562 QQEE 565
Score = 47.0 bits (110), Expect = 4e-05
Identities = 35/154 (22%), Positives = 80/154 (51%), Gaps = 16/154 (10%)
Query: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
+K + + K++ Q K + E +E K+ +++ M+E + E+ ++E K +E+E
Sbjct: 432 EKMRRQEEKIREQEKKIRE--QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK--MQEQE 487
Query: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
E+ +EE++ ++ ++ E+EE+ ++EE +++ K + EE E+E
Sbjct: 488 EKMRRQEEKIREQEKKIR-----------EQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 536
Query: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
+++E E+ + E E E ++E+K++E
Sbjct: 537 EKMQEQE-EKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 85.1 bits (209), Expect = 1e-16
Identities = 79/409 (19%), Positives = 185/409 (45%), Gaps = 28/409 (6%)
Query: 70 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129
L+++ K EE ++ + ++ EE + V KEE+K EE + + E +EEE
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 130 VAAKKSPVKATAPEVKEEEGE------------KEEEEGQEEEEEEDEGAKSDQAEEGGS 177
+K + E +EEE + K+EEE +E++EE E + + +E
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 178 EKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 237
E++ E+EE +++ E E E E + + E++ E + +++ +++L + ++ + ++
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 238 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297
+ ++ + + + + + + + EE+ + + E++ K +
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQK-------EEEEKEVKEAPKEEKVEKKEEKPK 350
K + + E K + + + E++ EEEE+ ++ +E+++ +++E+ +
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK-EEGKPLQQEKEKEKAGGEGGS-- 407
+ K++ E ++ + + + + E+ K EE K L+QE+ +++ E
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 408 ------EEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
EEE + K ++E + + E E +EQE + + + EE
Sbjct: 576 DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Score = 77.4 bits (189), Expect = 3e-14
Identities = 83/408 (20%), Positives = 178/408 (43%), Gaps = 41/408 (10%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
+++ E ++ E+ E E +K E++E + + E E E E +K +
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 138 KATAPEVK-------EEEGEKEEEEGQE-------EEEEEDEGAKSDQAEEGGSEKEGSS 183
K E + EEE +E++E +E EE E + K + EE ++ S
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE-QRLKRQEEEERLQQRLRSE 535
Query: 184 EKEEGEQEE-------GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEK 236
++ EQEE E E E E E + +++ EE+ +++ +EE ++++ ++
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 237 -------AKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 289
+ V + EE+ + + + EE+ + + KS +E+ + + +E+
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 290 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK-----EEKVEK 344
+ + + EE+ + + K EE + + E+ + EQ++ E+ PK E + +
Sbjct: 656 EQRLKREEEEERLEQRL-KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714
Query: 345 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
++ K P K++ + +E+ + + L+ + +E QQE+E+ +
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKR-----RRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 405 GGSEEEGSDKGAKG-SRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
EE S++G + S + + E + + E Q+ +++ EEEK
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Score = 77.0 bits (188), Expect = 4e-14
Identities = 83/435 (19%), Positives = 198/435 (45%), Gaps = 33/435 (7%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
++Q+ + + KL+ Q E +E + + ++ E+ L EE +EE++E E
Sbjct: 270 ELQEEEEQLRKLERQELRRER--QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKE-------EEEGQEEEEEEDEGAKSDQ 171
+E++ E E+++ ++ + ++EE +E EEE +E++ ++ + +Q
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 172 --AEEGGSEKEGSSEKEE----GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
E +E +E+ +Q E + E + +EE++ E+K E+ ++ L
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG----KSPVPKSPVEEKGKSPVP 281
+ + + + + +E+ K + + EE+ K + +++ +
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 282 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 341
+ EE+ + + + EE+ + + +S + + + E + K EEEK +++ +E++
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRL-RSEQQLRREQEERREQLLKREEEKRLEQERREQR 566
Query: 342 VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK-EEGKPLQQEKEKEK 400
+++++E+ +D K++ E + + + + LE+ K EE + L+QE+ +E+
Sbjct: 567 LKREQEERRDQLLKREEERRQQR--------LKREQEERLEQRLKREEVERLEQEERREQ 618
Query: 401 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDL 460
EEE + K +E+ + +QE +E+ REEE+ + L
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEE----RRQQQLRREQQERREQRLKREEEEERLEQRLKR 674
Query: 461 SPADEKKGGDKSEEK 475
+E++ + +EE+
Sbjct: 675 EHEEERREQELAEEE 689
Score = 76.3 bits (186), Expect = 7e-14
Identities = 78/409 (19%), Positives = 193/409 (47%), Gaps = 35/409 (8%)
Query: 73 QHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSM-KEEKKEAAEEKEEEPEAEEEEVA 131
+ + + + E ++ E+ E E L EE + + E++ E++E + + E
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 132 AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE---- 187
++ +K E E+ ++EE E E+EE ++ K ++ EE ++ SE++E
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 188 ---GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244
+++ E + EE E + E++++ + EE ++EL + + + E+ KS +PK
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 245 PVEEKGKSPVPKSPVEEK-GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAK 303
+ + ++ +S V + K + E++ K +S ++ + + + EE+ +
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 304 SPVPKSPVEEAKSKAEVGKGE------QKEEEEKEVKEAPKEEKVEK--KEEKPKDVPEK 355
+A+ K+E G+ +E+ E++++ ++++ ++ EE+ K+ +
Sbjct: 765 RDFTWQ--WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGS-------E 408
++ E + + + E + + + ++ +EE LQ+++E+ ++ + E
Sbjct: 823 QRREREKELQFLEEEEQLQRRERA---QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879
Query: 409 EEGSDKG----AKGSRKEDIAVNGEV--EGKEEVEQETKEKGSGREEEK 451
EE + AK + +E + ++ E +EE+++E +EK +E+E+
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Score = 74.3 bits (181), Expect = 3e-13
Identities = 80/396 (20%), Positives = 176/396 (44%), Gaps = 30/396 (7%)
Query: 81 IEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKAT 140
+EE + +++ E+ L EE +E++ + EE+E + E ++ +
Sbjct: 491 LEEEERREQQERREQQLRREQEE----RREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Query: 141 APEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ--------EE 192
+K EE ++ E+E +E+ + ++ + DQ + E+ K E E+ EE
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 193 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEE----LVADAKVEKPEKAKSPVPKSPVEE 248
E + E E K E+ EE+ +++ EE + E+ E+ + + + EE
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 249 KGKSPVPKSPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
+ + + + EE+ + + + E E+ KS +PK + + ++ +S V + +
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQ 726
Query: 306 VPKSPVEEAKSKAEVGKGE-QKEEEEKEVKEAPKEEKVE------KKEEKPKDVPEKKKA 358
+ +E + K + E Q +EEE+ ++ +EE+ + EEK + ++ A
Sbjct: 727 EGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 359 ESPVKEEAVAEVVTITKSVKVHL---EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKG 415
P++E+ ++ + + E+E KE+ + ++E+EKE E + + ++
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846
Query: 416 AKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
+ +ED + + E + EQ +K + EE+
Sbjct: 847 QQLQEEED-GLQEDQERRRSQEQRRDQKWRWQLEEE 881
Score = 72.8 bits (177), Expect = 8e-13
Identities = 71/417 (17%), Positives = 184/417 (44%), Gaps = 34/417 (8%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
E ++++ + E+++ E + EE +++++E E E E E++ ++
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE------------GSSEK 185
+ E+ + E +E E + EEE+ + K + EE E++ G EK
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 186 EEGEQEEGETEAEAEGEEAEAKEE---KKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
++ +E + + E E+ K E +K EEK +E EE ++++ E+ +
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE----EEPQRQRELQEEEEQLRKLE 282
Query: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA 302
+ + + + EE+ + + + + + + EE+ + + EE+
Sbjct: 283 RQELRRERQE-------EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 303 KSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 362
+ + + E + + +++EEE+ ++ +E++ E++E++ + + ++ +
Sbjct: 336 EQQLRREQEERREQQL-----RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 363 KEEAVAEVVTITKSVKVHLEKETKEE---GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 419
+E+ + + + ++ E++ + E + Q +E+E+ E E+E ++ K
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 420 RKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 476
++E E E EQE +++ R++E+ L L + ++ ++ E+++
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Score = 72.0 bits (175), Expect = 1e-12
Identities = 62/350 (17%), Positives = 171/350 (48%), Gaps = 11/350 (3%)
Query: 103 ELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 162
EL +EEK++ E+++ EEEE +K + T +EE+ ++EE + Q E +E
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRK---RETVLRKEEEKLQEEEPQRQRELQE 273
Query: 163 EDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
E+E + + +E E++ ++++ + E + + E E E +EE++ +++ E +
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE-QQE 332
Query: 223 EELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 282
E + E+ E+ + + + EE+ + + + EE+ + + + ++ + +
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE--QQLRREQQLR 390
Query: 283 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 342
+ + + + + E++ + ++ + + ++ + +++E E++ ++ +E+++
Sbjct: 391 REQQLRREQQLRR---EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 343 EKKEEKPKD-VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKA 401
++++E+ +D + +++ E +E ++ + + + +EE + QQE+ +++
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 402 GGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
E E K + + + E + + E ++E +E+ REEEK
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRRE-QEERREQLLKREEEK 556
Score = 72.0 bits (175), Expect = 1e-12
Identities = 89/434 (20%), Positives = 179/434 (41%), Gaps = 51/434 (11%)
Query: 62 KPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 121
KP ++ K Q EE E + E EK +E EE + +EE+ EE+E+
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL-LREEREK 950
Query: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEK-----------EEEEGQEEEEE-------- 162
E E K ++ ++ EE EK EEEE Q+EEE+
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 163 ------EDEGAKSDQAEEGGS-------EKEGSSEKEEGEQEEGETEAEAE---GEEAEA 206
E + K D+ ++ EK E+E +EE E + E E GEE E
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 207 KEEKKVE---EKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG 263
+ +++E K EE+ +EE + E+PEK + + E+ + + + +
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLR---EEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 264 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 323
+ + +E + + + V+++ + + + P + + + + EE + E
Sbjct: 1128 REKRRRQELERQYRE---EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 324 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEK 383
+++E+ ++ +E E+ E + +K K + S +K + E + KV+ +
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 384 ETKEEGKPLQQEKEKEKAGGE------GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
E+ + L+ + +++ + G +E ++ + ++ D E + + E +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 438 QETKEKGSGREEEK 451
+E K + +EEK
Sbjct: 1305 KEAKRRDRKSQEEK 1318
Score = 69.7 bits (169), Expect = 6e-12
Identities = 91/406 (22%), Positives = 178/406 (43%), Gaps = 66/406 (16%)
Query: 82 EETKVEDEKSEMEEALTAIT--EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKA 139
EE + + K E EE L EE+ +EE++E ++EE E +++ + +
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 140 TAPEVKEEEGEKEEEE-GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQE------- 191
+++ E+ E+ E+ +EEEEE E + EE E+E + E++E +E
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 192 ----EGETEAEA------------EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
+ E+EA+A EG+ ++E+K + E+ +EE A + ++ E
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 236 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 295
+ + + EEK E+G+ + P P+ E+ + +
Sbjct: 763 QRRDFTWQWQAEEK----------SERGRQRLSARP------------PLREQRERQLR- 799
Query: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEK 355
EE+ + P EE K + + Q+ E EKE++ +EE+++++ E+ + + E+
Sbjct: 800 --AEERQQREQRFLPEEEEKEQ----RRRQRREREKELQFLEEEEQLQRR-ERAQQLQEE 852
Query: 356 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEE-----GKP-LQQEKEKEKAGGEGGSEE 409
+ +E ++ + + LE+E K KP LQ++ KE+ + EE
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 410 EGSDKGAKGSRKEDIAVNGEVE----GKEEVEQETKEKGSGREEEK 451
++ K R+E E E +E++ +E +EK +E E+
Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Score = 66.2 bits (160), Expect = 7e-11
Identities = 76/412 (18%), Positives = 191/412 (46%), Gaps = 28/412 (6%)
Query: 51 RPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKE 110
RPP+ + Q E + + + +F+ E E+ + ++ E E+ L + EE +
Sbjct: 787 RPPLREQRERQLRAEE--RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL---- 840
Query: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
+++E A++ +EE + +E+ ++S E + ++ + + E + + AK
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQ------EQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230
E+ E++ E+EE Q E + + +E + +EE++++++ E++ +E K
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER----EK 950
Query: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
+ E+ + +++K + + + P + + + K EE+ + + EE+ K
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 291 SPVSKSPVEEKAKSPVPKSP---VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 347
+ + + K + + + E + K + + E++ EE+E+++ ++ E++E
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 348 KPKDVPEK--KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE------KEKE 399
+ + E+ +K E +EE K + E++ +EE + LQQE +E+E
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE-EELQQEEEQLLREERE 1129
Query: 400 KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
K + + ++ + ++ + E ++E+E++ +E+ ++EE+
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Score = 65.1 bits (157), Expect = 2e-10
Identities = 71/350 (20%), Positives = 164/350 (46%), Gaps = 33/350 (9%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
++Q+ + + + + + + ++E + + E+E + EE L E + + ++ E
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE---TRRRQELERQYR 1081
Query: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
KEEE + EEE++ ++ P K + +E E++ E +E ++EE++ + ++ + E
Sbjct: 1082 KEEELQQEEEQLL-REEPEKR-----RRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Query: 179 KEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
E +EE Q+E E E E+ +E ++ + EE+ +EE + + EK + +
Sbjct: 1136 LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298
+ EE+ + K ++ + K E + ++ V + V KG+
Sbjct: 1196 ERQYRE--EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR-------- 1245
Query: 299 EEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEA--------PKEEKVEKKEEK 348
E + + S + + +S+ ++ GEQ+E + ++ + P+EE++E++E+K
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 398
++K E E+ + K + +++ +EE + LQ+ +E+
Sbjct: 1306 EAKRRDRKSQE----EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Score = 61.2 bits (147), Expect = 2e-09
Identities = 79/448 (17%), Positives = 197/448 (43%), Gaps = 42/448 (9%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
K ++P+ E + ++ + EE ++ +++ E+ L EE + + +++ E
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 119 KEEEPEAEEEEVAAKKSPVKATAPEVK---EEEGEKEE---------EEGQEEEEEEDEG 166
+E+E EE+E A ++ +K+ P+ + E E + + +EGQ +E++E
Sbjct: 681 REQELAEEEQEQARER--IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV-------EEKSEEV 219
+ ++E E+E + +++ E++ + + + EE + +++ E++ ++
Sbjct: 739 RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 220 ATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG-KS 278
+E + + E+ K + E + + + + + + + EE G +
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 279 PVPKSPVEEKGKSPVSKSPVEEKAK----SPVPKSPVEEAKSKAEVGKGEQKEE---EEK 331
+ +E+ + + +EE+ K + K ++E K + E++EE EE+
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 332 EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKET---KEE 388
E + ++E+ ++EE+ + E+ E K K K+ ++E +E
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 389 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGRE 448
K +QE+EK+ E +EE ++ + E ++E E++ ++K ++
Sbjct: 979 EKRRRQEREKKYREEEELQQEE----------EQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 449 EEKGVVTNGLDLSPADEKKGGDKSEEKV 476
EE+ ++ + E++ + EE++
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEEL 1056
Score = 59.3 bits (142), Expect = 9e-09
Identities = 69/374 (18%), Positives = 168/374 (44%), Gaps = 22/374 (5%)
Query: 88 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA--EEEEVAAKKSPVKATAPEVK 145
+E+SE +E L + EE +E +E E EEE++ + K P+ +
Sbjct: 152 EEQSEKQERLEQRDRQ---RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 146 E-------EEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 198
+ E K EE Q++ E + ++ E+ ++E KEE + +E E + +
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 199 AEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
E +E E + K + +E E +E+ + E+ + K + +E+ + +
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328
Query: 258 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK 317
+E+ + + EE+ + + + EE+ + + + EE+ + + + + +
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ 388
Query: 318 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
+ ++E++ + ++ +E+++ ++++ ++ +++ E E+ + +
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ-----ERR 443
Query: 378 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
+ L++E +E L++E+E E+ E ++ D+ + R+E E E +E +
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ--EEERRERWLKLEEEERRE--Q 499
Query: 438 QETKEKGSGREEEK 451
QE +E+ RE+E+
Sbjct: 500 QERREQQLRREQEE 513
Score = 56.6 bits (135), Expect = 6e-08
Identities = 61/333 (18%), Positives = 157/333 (47%), Gaps = 24/333 (7%)
Query: 127 EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKE 186
+EE A+ ++ + ++EE ++ E + EEE + + +E E+E + +E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQE--QERELAEGEE 153
Query: 187 EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV 246
+ E++E + + + + E +++ ++ EE +EE + K + E + P
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETE-------EFPD 206
Query: 247 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 306
EE+ + + KG+ + E + + + E + + V + EEK +
Sbjct: 207 EEQLRRR-ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE-EEKLQEEE 264
Query: 307 PKSPVEEAKSKAEVGKGEQKE------EEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 360
P+ E + + ++ K E++E EEE++ + +E+++ +K+E+ + ++++ E
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 361 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
+ E E + ++ E+E + E + L++E+E+E+ + E+E + + R
Sbjct: 325 QERREQQEE----RREQQLRREQEERRE-QQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 421 KEDIAVNGEVEGKEEV--EQETKEKGSGREEEK 451
++ + ++ ++++ EQ+ + + R E++
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Score = 56.2 bits (134), Expect = 7e-08
Identities = 80/465 (17%), Positives = 208/465 (44%), Gaps = 33/465 (7%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
K ++ + + + + + KF+EE + + K EE L EE + +E ++ EE
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 119 KEEEPEAEEEEVAAKKSPVKATAPEVK--EEEGEKEEEEGQEE-EEEEDEGAKSDQAEEG 175
E++ +E + ++ +++ PE K EEE + ++ Q + +EE + + ++ ++
Sbjct: 1491 -EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 176 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK---EEKKVEEKSEEVATKEELVADAKVE 232
+++ +EE ++E E E + +E + K EE+KV + +E E+ + E
Sbjct: 1550 RQDRDRKFREEEQLRQERE-EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 233 KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 292
++ + E K + ++E+ + + + + K P+ +E+ +
Sbjct: 1609 GQQQLRQ-------ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 293 VSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDV 352
+ + + + + E+ + E + ++EE++ +E ++ E+++ + +++
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 353 PEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS 412
K + E +++E E + + + LE+E L+ E+E+++ + +
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEE------QLRPEREEQQLRRQERDRKFRE 1775
Query: 413 DKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKS 472
++ + R+E + E + K E++ +++ REE++ L P ++ G +
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQE---REEQQ--------LRP-QQRDGKYRW 1823
Query: 473 EEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 517
EE+ + + E+ + D + + T + E +E ++E+
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEE 1868
Score = 51.6 bits (122), Expect = 2e-06
Identities = 70/386 (18%), Positives = 170/386 (44%), Gaps = 40/386 (10%)
Query: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137
EE + + + E + S E EE V +E++++ E++++ E ++ ++
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 138 KATAPEVKEEEGEKEEEEGQEEE----EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 193
K E +E E+++ QE + EEE + + ++ ++ +++ +EE +EG
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679
Query: 194 ETE----AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 249
E + E + + E +++ + +E+ + +E+ + ++E+ + + + + +E+
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 250 -GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK 308
+ + +EE+ P E+ + + + + K + EE+ + +
Sbjct: 1740 LRRQERYRKILEEEQLRP-------EREEQQLRRQERDRKFRE-------EEQLRQEREE 1785
Query: 309 SPVEEAKSKAEVGKGEQ--KEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA 366
+ +S + + EQ +E EE++++ ++ K +EE+ + ++++ +
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQY 1845
Query: 367 VAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAV 426
AE T+ EK +EE + Q+E++K + E EE + K ++
Sbjct: 1846 RAEEQFATQ------EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV- 1898
Query: 427 NGEVEGKEEVEQETKEKGSGREEEKG 452
GE++ +E KG GR E G
Sbjct: 1899 -GEIKSQE-------GKGHGRLLEPG 1916
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/229 (20%), Positives = 101/229 (44%), Gaps = 17/229 (7%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM-----------EEALTAITEELAVS 107
K + + + + +++ KF EE E+ + E E+ ++ EE L EE +
Sbjct: 1708 KFLQEEQQLRRQELERKFREE--EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765
Query: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA 167
+E ++ EE++ E EE+++ +++S K E +E E+++ Q+ + +
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE--AKEEKKVEEKSEEVATKEEL 225
+ Q EE +++ +E+ T+ ++ EE E +EE+K ++ E +E +
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 274
K E+ + + E KG + + + PV SP+ E
Sbjct: 1886 RRQQKEEQRHRQVGEIKSQ--EGKGHGRLLEPGTHQFASVPVRSSPLYE 1932
Score = 48.1 bits (113), Expect = 2e-05
Identities = 67/400 (16%), Positives = 172/400 (43%), Gaps = 27/400 (6%)
Query: 72 VQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA 131
+QH E+ + + E + + + E+L ++E K + +EE + EE
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 132 AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ---AEEGGS--EKEGSSEKE 186
K+ + +EE+ +E EE +E D + ++ E+G E+E ++
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 187 EGE----QEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
E E +EE + + ++ ++K E+ ++++ +E D K + E+ V
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER---DRKFREEEQ---QVR 1440
Query: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK---GKSPVSKSPVE 299
+ E K + E K + ++E+ + + + + K + + + +
Sbjct: 1441 RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Query: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
K + +S E K E + +++ + K ++E + + E+ +++ +D K + E
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560
Query: 360 SPVKEEAVAEVVT-ITKSVKVHLEKE----TKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
+++E + ++ + K LE++ ++E K ++ E++ + G+ +E K
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 415 GAKGSR----KEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
+ + +E+ ++ + ++ +E+E + + RE++
Sbjct: 1621 FREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Score = 47.0 bits (110), Expect = 4e-05
Identities = 56/304 (18%), Positives = 129/304 (42%), Gaps = 17/304 (5%)
Query: 149 GEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE 208
G EE+ + + +E + + ++ E +EE Q + E E E AE +E
Sbjct: 94 GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153
Query: 209 EKKVEEKSE--EVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 266
+ + +E+ E + ++E + + E E+ + + ++ + P EE+ +
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326
+ KG+ + E + + + E + + V + E+ + + + E +
Sbjct: 214 -ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 386
EEEE+ K +E + E++EE+ + +++ + K+E +E +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--------------EERREQQ 318
Query: 387 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 446
EE + Q+ +E+++ E E ++ + R+E E + + E E+E +E+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 447 REEE 450
RE++
Sbjct: 379 REQQ 382
Score = 44.3 bits (103), Expect = 3e-04
Identities = 49/264 (18%), Positives = 111/264 (42%), Gaps = 32/264 (12%)
Query: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVE-DEKSEMEEALTAITEELAVSMKE------E 111
K ++ + + + + + KF++E + + E + K EE L TE+ + +E E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 112 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
+++ E+EE+ +E ++ + +EE+ QE EE++ +SD+
Sbjct: 1752 EEQLRPEREEQQLRRQE----------------RDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 172 --AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA 229
EE +E ++ +Q +G+ E E + E +E++ +E+ + +E+
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Query: 230 KVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 289
K + E+ + ++ + + + + + K E++ + E KG
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE-------EQRHRQVGEIKSQEGKG 1908
Query: 290 KSPVSKSPVEEKAKSPVPKSPVEE 313
+ + + A PV SP+ E
Sbjct: 1909 HGRLLEPGTHQFASVPVRSSPLYE 1932
Score = 40.0 bits (92), Expect = 0.005
Identities = 52/286 (18%), Positives = 121/286 (42%), Gaps = 25/286 (8%)
Query: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKK 134
KF+EE + + E E+ + EE + + E+++ ++ + EEE+ ++
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Query: 135 SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194
+ E ++ ++ E + +EEE+ E + + K E+ E+EE +
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Query: 195 TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPV 254
+ + +E+ + E + +++ ++E +D K + E+ + +E+ + +
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQE---SDRKFREEEQLR--------QEREEQQL 1812
Query: 255 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEA 314
+ K + + +EE+ E++ + + E+ + KS EE
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQ----------EQRLRQERDRQYRAEEQFATQEKSRREEQ 1862
Query: 315 KSKAEVGKGEQKEEEEKEVKEAPKE-EKVEKKEEKPKDVPEKKKAE 359
+ E EQK +E+E K + + +K+E++ + V E K E
Sbjct: 1863 ELWQE---EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 84.0 bits (206), Expect = 3e-16
Identities = 108/465 (23%), Positives = 181/465 (38%), Gaps = 87/465 (18%)
Query: 80 IIEETKVEDEKSEMEEALTAITEELAVSMKEEKK---EAAEEKEEEPEAEEEEV---AAK 133
+I V +E+ E E+ + E+ + KEE++ A ++ + + + + +
Sbjct: 991 LISNAAVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPE 1050
Query: 134 KSPV---KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ 190
PV + E+ +E E+EEEE EEEEEE+E + D+ EE E+E E+EE Q
Sbjct: 1051 SRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEE---EEEEEEEEEENIQ 1107
Query: 191 EEGETEAEAEGEEAEAKEEKKVEEK-----------------SEEVATKEELVADAKVEK 233
+ + + K +++K SE E ++ E+
Sbjct: 1108 SSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEER 1167
Query: 234 PEKAKSPVPKSPVEEKGKSPVPKSPVEEK-GKSPVPKSPVEEKGKS--------PVPKSP 284
P P + VEE G+ PV + + + GK + EE+GK P +
Sbjct: 1168 PMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKK---RQTEEEEGKDNHCFKNADPCRNNM 1224
Query: 285 VEEKG--KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK-------E 335
++ K +P K K PK +K + K Q +E + K E
Sbjct: 1225 NDDSSNLKEGSKDNPEPLKCKQVWPKG------TKRGLSKWRQNKERKTGFKLNLYTPPE 1278
Query: 336 APKEEKVEKKEEKPKDVPEKKKAESPVK--------------------EEAVAEVVTITK 375
P E + E+ K+ E K + SP++ EE A V T
Sbjct: 1279 TPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTS 1338
Query: 376 SVK------VHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGE 429
+ + E+E +EE + ++E+E+E EGG E GAK KE+ ++ E
Sbjct: 1339 PGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTE 1398
Query: 430 VEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEE 474
E ++ +E EEE ++ D DE +S E
Sbjct: 1399 KEDSARLDDHEEE-----EEEDEEPSHNEDHDADDEDDSHMESAE 1438
Score = 79.3 bits (194), Expect = 8e-15
Identities = 111/468 (23%), Positives = 185/468 (39%), Gaps = 107/468 (22%)
Query: 107 SMKEEKKEAAEEKEEEPEA------EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 160
++ EE++EA +E E E EE+E+ + ++ + + +V+ + E +
Sbjct: 996 AVSEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVT 1055
Query: 161 EEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 220
E G + ++E E+E ++EE E+EE E E E E EE E +EE++ + S
Sbjct: 1056 GER--GQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRL 1113
Query: 221 TKEELVA----------DAKVEKPEKAKSPVPKSPVEEKGK---SPVPKSPVEE--KGKS 265
TK + VA + K + S V + E + P S E
Sbjct: 1114 TKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLE 1173
Query: 266 PVPKSPVEEKGKSPV-----------PKSPVEEKGKS--------------PVSKSPVEE 300
P + VEE G+ PV + EE+GK S ++E
Sbjct: 1174 PTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKE 1233
Query: 301 KAK---SPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK-------EAPKEEKVEKKEEKPK 350
+K P+ V +K + K Q +E + K E P E + E+ K
Sbjct: 1234 GSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQK 1293
Query: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL--QQEKEKEKAGGEGGSE 408
+ E K + SP++ +E+E KE G+ L Q+E +E+
Sbjct: 1294 ETSEGKTSPSPIR-----------------IEEEVKETGEALLPQEENRREETCA----- 1331
Query: 409 EEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG 468
S + G + ED + E E +EE E+E +E+ EEE+G ++
Sbjct: 1332 -PVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGG-------GNVEKDPD 1383
Query: 469 GDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEE 516
G KS+E K +I++E D A ++++HEE EE
Sbjct: 1384 GAKSQE-----KEEPEISTEKEDSA------------RLDDHEEEEEE 1414
Score = 73.2 bits (178), Expect = 6e-13
Identities = 65/204 (31%), Positives = 97/204 (47%), Gaps = 29/204 (14%)
Query: 47 LYTHRPPITISSKIQKPKVEAPKLKVQHKF------VEEIIEETK---VEDEKSEMEEAL 97
LYT PP T ++ VE K + K +EE ++ET + E++ EE
Sbjct: 1273 LYT--PPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETC 1330
Query: 98 TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 157
++ + K E E+EEE E EEEE +EEE E EEEEG
Sbjct: 1331 APVSPNTSPGEKPEDDLIKPEEEEEEEEEEEE---------------EEEEEEGEEEEGG 1375
Query: 158 EEEEEEDEGAKSDQAEEG--GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 215
E++ +GAKS + EE +EKE S+ ++ E+EE E E + E+ +A +E +
Sbjct: 1376 GNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHME 1435
Query: 216 SEEVATKEELVADAKVEKPEKAKS 239
S EV KEEL ++ E E ++
Sbjct: 1436 SAEV-EKEELPRESFKEVLENQET 1458
Score = 72.4 bits (176), Expect = 1e-12
Identities = 54/173 (31%), Positives = 86/173 (49%), Gaps = 12/173 (6%)
Query: 82 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATA 141
E+ VE++K E T + ++EE KE E + E EE A SP +
Sbjct: 1285 EQVTVEEQKETSEGK----TSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPG 1340
Query: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS--EKEGSSEKEEGEQEEGETEAEA 199
+ +++ + EEEE +EEEEEE+E + + EEGG EK+ K + E+EE E E
Sbjct: 1341 EKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQ-EKEEPEISTEK 1399
Query: 200 EGEEAEAKEEKKVEEKSEEVATKEELVA----DAKVEKPEKAKSPVPKSPVEE 248
E + A + ++ EE+ EE + E+ A D+ +E E K +P+ +E
Sbjct: 1400 E-DSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKE 1451
Score = 61.2 bits (147), Expect = 2e-09
Identities = 100/421 (23%), Positives = 160/421 (38%), Gaps = 83/421 (19%)
Query: 100 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE 159
+T E ++ K+ + EE+EEE E EEEE +EEE E EEEE +EE
Sbjct: 1054 VTGERGQLLELSKESSEEEEEEEDEEEEEE---------------EEEEEEDEEEEEEEE 1098
Query: 160 EEEEDEGAKSD-------QAEEGGSEKEGSSEKEEGEQEE---GETEAEAEGEEAEAKEE 209
EEEE+E +S Q+ ++ +K+ G + E E E E
Sbjct: 1099 EEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNE 1158
Query: 210 KKVEEKSEEVATKEELVADAKVEKPEKAKSPV-----------PKSPVEEKGKS------ 252
+ S+E +L ++E E + PV + EE+GK
Sbjct: 1159 PF--DNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKN 1216
Query: 253 ------------------------PVPKSPVEEKG-KSPVPKSPVEEKGKSPV------- 280
P+ V KG K + K ++ K+
Sbjct: 1217 ADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTP 1276
Query: 281 PKSPVEEKGKSPVSKSPVEEKAK-SPVPKSPVEEAKSKAE-VGKGEQKEEEEKEVKEAPK 338
P++P+E + V + + K SP P EE K E + E+ EE +P
Sbjct: 1277 PETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPN 1336
Query: 339 EEKVEKKEE---KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395
EK E+ KP++ E+++ E +EE E +V+ + +E + +
Sbjct: 1337 TSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEIS 1396
Query: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT 455
EKE + EEE ++ + S ED + E + E + KE+ RE K V+
Sbjct: 1397 TEKEDSARLDDHEEE-EEEDEEPSHNEDHDADDEDDSHMESAEVEKEE-LPRESFKEVLE 1454
Query: 456 N 456
N
Sbjct: 1455 N 1455
Score = 38.1 bits (87), Expect = 0.021
Identities = 65/303 (21%), Positives = 103/303 (33%), Gaps = 38/303 (12%)
Query: 140 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK-EGSSEKEEGEQEEGETEAE 198
T PE E E+ E Q+E E + EE E E +EE +EE
Sbjct: 1275 TPPETPMEPDEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVS 1334
Query: 199 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 258
E E+ ++ + EE +EE E+ E+ EE+G+
Sbjct: 1335 PNTSPGEKPEDDLIKPEEEEEEEEEE-------EEEEE----------EEEGE------- 1370
Query: 259 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKA 318
EE+G V K P K + EK S EE EE +
Sbjct: 1371 -EEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEE-----------EEEDEEP 1418
Query: 319 EVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVK 378
+ ++E+ E+ + EK E E K+V E ++ + + +
Sbjct: 1419 SHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCG 1478
Query: 379 VHLEKETKEEGKPLQQEKEK-EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
V L E K L + E ++ E E+ + K S++ D E++
Sbjct: 1479 VDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEID 1538
Query: 438 QET 440
ET
Sbjct: 1539 SET 1541
Score = 33.9 bits (76), Expect = 0.39
Identities = 33/162 (20%), Positives = 64/162 (39%), Gaps = 14/162 (8%)
Query: 95 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 154
E L +L S E KE A + E PE++EE P E+ +++++
Sbjct: 1472 EVLMDCGVDLTASCNSEPKELAGDPEAVPESDEE-------------PPPGEQAQKQDQK 1518
Query: 155 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA-EAKEEKKVE 213
+E + E EG + + + + S +E +++ + AE +EA + +
Sbjct: 1519 NSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRA 1578
Query: 214 EKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVP 255
++S ++AT + + P + P V VP
Sbjct: 1579 DQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVP 1620
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.292 0.117 0.292
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,745,736
Number of Sequences: 37866
Number of extensions: 1736336
Number of successful extensions: 96613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1809
Number of HSP's successfully gapped in prelim test: 1917
Number of HSP's that attempted gapping in prelim test: 10405
Number of HSP's gapped (non-prelim): 25936
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.