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Search of human proteins with 157427195
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157427195 hypothetical protein LOC347475 [Homo sapiens]
(325 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157427195 hypothetical protein LOC347475 [Homo sapiens] 636 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 2e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 2e-10
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 61 2e-09
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 57 2e-08
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 57 2e-08
gi|34577114 cytomatrix protein p110 [Homo sapiens] 57 2e-08
gi|58530840 desmoplakin isoform I [Homo sapiens] 56 5e-08
gi|31982906 cingulin-like 1 [Homo sapiens] 55 8e-08
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 54 1e-07
gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 53 3e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 53 4e-07
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 53 4e-07
gi|4503593 epidermal growth factor receptor pathway substrate 15... 52 6e-07
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 52 7e-07
gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 51 1e-06
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 51 1e-06
gi|38044112 restin isoform b [Homo sapiens] 51 2e-06
gi|4506751 restin isoform a [Homo sapiens] 51 2e-06
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 51 2e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 50 2e-06
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 50 2e-06
gi|215982794 myosin VA isoform 2 [Homo sapiens] 50 3e-06
gi|148746195 trichohyalin [Homo sapiens] 50 3e-06
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 50 4e-06
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 50 4e-06
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 50 4e-06
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 49 5e-06
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 49 5e-06
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 49 5e-06
>gi|157427195 hypothetical protein LOC347475 [Homo sapiens]
Length = 325
Score = 636 bits (1640), Expect = 0.0
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MDARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESK 60
MDARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESK
Sbjct: 1 MDARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESK 60
Query: 61 FKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTC 120
FKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTC
Sbjct: 61 FKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTC 120
Query: 121 STDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKK 180
STDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKK
Sbjct: 121 STDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKK 180
Query: 181 EIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRN 240
EIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRN
Sbjct: 181 EIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRN 240
Query: 241 LKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE 300
LKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE
Sbjct: 241 LKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE 300
Query: 301 LLRKYYASSMVTSSSILDHFTGDFF 325
LLRKYYASSMVTSSSILDHFTGDFF
Sbjct: 301 LLRKYYASSMVTSSSILDHFTGDFF 325
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 63.9 bits (154), Expect = 2e-10
Identities = 79/288 (27%), Positives = 132/288 (45%), Gaps = 41/288 (14%)
Query: 35 QTTADSSKGMEEIYNLSS-RKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETD- 92
+TT DS +G N S K ++E++ KK NEI QE+ +N +N+SK+
Sbjct: 480 RTTVDSVEG-----NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 93 ------TNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLC 146
T E+S + E N N T S+ + + + R K +E+ +
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDIEKEN---- 589
Query: 147 LNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQAL 206
+L+E ++E + K KIE E +KEL HYK+ K +E E + + L+
Sbjct: 590 -KILHESIKETSSKLSKIEFEKRQIKKELEHYKE----KGERAEELENEL----HHLEKE 640
Query: 207 RNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQT------EVGNVLLK 260
L +K TN+K E+++ ++ +L ENR LK+ + K+ T E N L
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 261 EE----MKSYYELEMAKIR-GELSVIKNELRTEKTLQARNNRALELLR 303
EE ++ L+ A ++ +L + EL +EK + + LELL+
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEK---EQLKKGLELLK 745
Score = 41.2 bits (95), Expect = 0.001
Identities = 56/265 (21%), Positives = 106/265 (40%), Gaps = 23/265 (8%)
Query: 60 KFKRKKYIFQLNEIEQE-QNLRENKRNISKNETDTNSASYE--SSNVDVTTEESFNSTED 116
K K ++ L ++ E + + NK + +E T+ + Y+ S ++ T ++S E+
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE 974
Query: 117 NSTC------STDNLPALLRQDIR--KKFMERMSPKLCLNLLNEELEELNMKYRKIEEEF 168
+ N LRQ+++ KK E + + + + ++ + K E E
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 169 ENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAK 228
+ +ELL K + E E + + E QAL+ L + T NL Q+ +
Sbjct: 1035 QETTRELLKVKDRLI-------EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 229 EVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYEL--EMAKIRGELSVIKNELR 286
L +N L+ KL+ + N M +L + + + E + E
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147
Query: 287 TEKTLQ---ARNNRALELLRKYYAS 308
K+L +++ LELL + AS
Sbjct: 1148 DLKSLYDSLIKDHEKLELLHERQAS 1172
Score = 39.3 bits (90), Expect = 0.005
Identities = 60/283 (21%), Positives = 117/283 (41%), Gaps = 36/283 (12%)
Query: 44 MEEIYNLSSRKFQEESKFKR-----KKYIFQLNEIEQEQN-LRENKRNISKNETDTNSAS 97
+E + +S +E K K+ K FQL +E+E + L E + +N AS
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS 717
Query: 98 YESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIR---------------KKFMERMS 142
+ + + + +E S ++ + L A ++ R +K +E +
Sbjct: 718 MKMAQLQLENKE-LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 143 PKLCLNLLNEELEELNMKYRKIE---EEFENAEKELLHYKKEIFTKPLNFQETETDASKS 199
K+ L EL++L M+ + ++ EE + + K L +KE + + E D +
Sbjct: 777 KKI--QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834
Query: 200 DYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLL 259
+ E + LR K T ++ + ++ ++ L+ E KE+ +LK L
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE--------L 886
Query: 260 KEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELL 302
++E K + I+ L ++ +L +EK + N LE L
Sbjct: 887 EKENKELVKRATIDIK-TLVTLREDLVSEKLKTQQMNNDLEKL 928
Score = 37.7 bits (86), Expect = 0.014
Identities = 29/141 (20%), Positives = 66/141 (46%), Gaps = 12/141 (8%)
Query: 133 IRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQET 192
++++ M +S + +EL+ L K ++++ E E+ YK+ + + F +
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDK----LESEVSRYKERLHD--IEFYKA 344
Query: 193 ETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQT 252
+ K D ++ L E T +++ E + + +H+L EN LK + ++ +
Sbjct: 345 RVEELKEDNQV------LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 253 EVGNVLLKEEMKSYYELEMAK 273
++ ++E M+ LEMA+
Sbjct: 399 DMDRKKIEELMEENMTLEMAQ 419
Score = 33.1 bits (74), Expect = 0.35
Identities = 23/107 (21%), Positives = 50/107 (46%), Gaps = 10/107 (9%)
Query: 190 QETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLK 249
Q + + + +++ LR +L EK + + ++L+Q + + +L EN NL R +
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 250 HQTEVGNVLLKEEMKSYYE--LEMAKIRGELSVIKNELRTEKTLQAR 294
+ ++E+ + E + + K+ E+S K L + +AR
Sbjct: 307 --------MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345
Score = 28.5 bits (62), Expect = 8.5
Identities = 64/339 (18%), Positives = 133/339 (39%), Gaps = 68/339 (20%)
Query: 18 SAQDVLEETSEPESSSEQTTADSSKGMEEIY-----NLSSRKFQEESKFKRKKYIFQLNE 72
S+ + E ++ E S++TT + K + + N + + ++ K + K+ Q N
Sbjct: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
Query: 73 IE-------------QEQNLRENKRN----ISKNETDTNSASYESSNVDVTTEESFNSTE 115
++ QEQN +N + + ++ S S + N + ++S E
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
Query: 116 DNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEEL------------------EEL 157
+ S R+D++ + + L LL+E + L
Sbjct: 1139 NESVIKE-------REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1191
Query: 158 NMKYRKIEEEF----------ENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALR 207
+++R +E+ + E+ EK L ++++ + N + + K E L
Sbjct: 1192 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251
Query: 208 NDLSE--KATNV-----KNLSEQLQQAKEVIHKLNLENRNLKEAVRKLK-HQTEVGNVL- 258
+ S+ K T V KNL L +K +L E LKE ++L T++ N
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1311
Query: 259 LKEEMKSYYELEMAKIRGELSVIKNELRT--EKTLQARN 295
L ++K E E + ++ + + RT E+ +++++
Sbjct: 1312 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 63.9 bits (154), Expect = 2e-10
Identities = 79/288 (27%), Positives = 132/288 (45%), Gaps = 41/288 (14%)
Query: 35 QTTADSSKGMEEIYNLSS-RKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETD- 92
+TT DS +G N S K ++E++ KK NEI QE+ +N +N+SK+
Sbjct: 480 RTTVDSVEG-----NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 93 ------TNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLC 146
T E+S + E N N T S+ + + + R K +E+ +
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDIEKEN---- 589
Query: 147 LNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQAL 206
+L+E ++E + K KIE E +KEL HYK+ K +E E + + L+
Sbjct: 590 -KILHESIKETSSKLSKIEFEKRQIKKELEHYKE----KGERAEELENEL----HHLEKE 640
Query: 207 RNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQT------EVGNVLLK 260
L +K TN+K E+++ ++ +L ENR LK+ + K+ T E N L
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
Query: 261 EE----MKSYYELEMAKIR-GELSVIKNELRTEKTLQARNNRALELLR 303
EE ++ L+ A ++ +L + EL +EK + + LELL+
Sbjct: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEK---EQLKKGLELLK 745
Score = 39.3 bits (90), Expect = 0.005
Identities = 60/283 (21%), Positives = 117/283 (41%), Gaps = 36/283 (12%)
Query: 44 MEEIYNLSSRKFQEESKFKR-----KKYIFQLNEIEQEQN-LRENKRNISKNETDTNSAS 97
+E + +S +E K K+ K FQL +E+E + L E + +N AS
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS 717
Query: 98 YESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIR---------------KKFMERMS 142
+ + + + +E S ++ + L A ++ R +K +E +
Sbjct: 718 MKMAQLQLENKE-LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
Query: 143 PKLCLNLLNEELEELNMKYRKIE---EEFENAEKELLHYKKEIFTKPLNFQETETDASKS 199
K+ L EL++L M+ + ++ EE + + K L +KE + + E D +
Sbjct: 777 KKI--QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834
Query: 200 DYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLL 259
+ E + LR K T ++ + ++ ++ L+ E KE+ +LK L
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE--------L 886
Query: 260 KEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELL 302
++E K + I+ L ++ +L +EK + N LE L
Sbjct: 887 EKENKELVKRATIDIK-TLVTLREDLVSEKLKTQQMNNDLEKL 928
Score = 37.7 bits (86), Expect = 0.014
Identities = 29/141 (20%), Positives = 66/141 (46%), Gaps = 12/141 (8%)
Query: 133 IRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQET 192
++++ M +S + +EL+ L K ++++ E E+ YK+ + + F +
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDK----LESEVSRYKERLHD--IEFYKA 344
Query: 193 ETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQT 252
+ K D ++ L E T +++ E + + +H+L EN LK + ++ +
Sbjct: 345 RVEELKEDNQV------LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 253 EVGNVLLKEEMKSYYELEMAK 273
++ ++E M+ LEMA+
Sbjct: 399 DMDRKKIEELMEENMTLEMAQ 419
Score = 36.6 bits (83), Expect = 0.031
Identities = 55/264 (20%), Positives = 103/264 (39%), Gaps = 22/264 (8%)
Query: 60 KFKRKKYIFQLNEIEQE-QNLRENKRNISKNETDTNSA-SYESSNVDVTTEESFNSTEDN 117
K K ++ L ++ E + + NK + +E T+ S ++ T ++S E+
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEK 974
Query: 118 STC------STDNLPALLRQDIR--KKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFE 169
+ N LRQ+++ KK E + + + + ++ + K E E +
Sbjct: 975 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1034
Query: 170 NAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKE 229
+ELL K + E E + + E QAL+ L + T NL Q+ +
Sbjct: 1035 ETTRELLKVKDRLI-------EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087
Query: 230 VIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYEL--EMAKIRGELSVIKNELRT 287
L +N L+ KL+ + N M +L + + + E + E
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERED 1147
Query: 288 EKTLQ---ARNNRALELLRKYYAS 308
K+L +++ LELL + AS
Sbjct: 1148 LKSLYDSLIKDHEKLELLHERQAS 1171
Score = 33.1 bits (74), Expect = 0.35
Identities = 23/107 (21%), Positives = 50/107 (46%), Gaps = 10/107 (9%)
Query: 190 QETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLK 249
Q + + + +++ LR +L EK + + ++L+Q + + +L EN NL R +
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 250 HQTEVGNVLLKEEMKSYYE--LEMAKIRGELSVIKNELRTEKTLQAR 294
+ ++E+ + E + + K+ E+S K L + +AR
Sbjct: 307 --------MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345
Score = 28.5 bits (62), Expect = 8.5
Identities = 64/339 (18%), Positives = 133/339 (39%), Gaps = 68/339 (20%)
Query: 18 SAQDVLEETSEPESSSEQTTADSSKGMEEIY-----NLSSRKFQEESKFKRKKYIFQLNE 72
S+ + E ++ E S++TT + K + + N + + ++ K + K+ Q N
Sbjct: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1077
Query: 73 IE-------------QEQNLRENKRN----ISKNETDTNSASYESSNVDVTTEESFNSTE 115
++ QEQN +N + + ++ S S + N + ++S E
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137
Query: 116 DNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEEL------------------EEL 157
+ S R+D++ + + L LL+E + L
Sbjct: 1138 NESVIKE-------REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190
Query: 158 NMKYRKIEEEF----------ENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALR 207
+++R +E+ + E+ EK L ++++ + N + + K E L
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1250
Query: 208 NDLSE--KATNV-----KNLSEQLQQAKEVIHKLNLENRNLKEAVRKLK-HQTEVGNVL- 258
+ S+ K T V KNL L +K +L E LKE ++L T++ N
Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1310
Query: 259 LKEEMKSYYELEMAKIRGELSVIKNELRT--EKTLQARN 295
L ++K E E + ++ + + RT E+ +++++
Sbjct: 1311 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1349
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 60.8 bits (146), Expect = 2e-09
Identities = 51/251 (20%), Positives = 120/251 (47%), Gaps = 13/251 (5%)
Query: 27 SEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNI 86
+E + Q ++ + +Y ++ +EE + K ++ + ++ E++ E+ + ++
Sbjct: 835 NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDL 894
Query: 87 SKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLC 146
++ + ++ + + E+ F T+++ ++ N + +D +E + L
Sbjct: 895 AETKAESEQLAR-----GLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLT 949
Query: 147 --LNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQET-ETDASKSDYEL 203
+ +L E EEL K +K EEE++ ++E + K F K +N + T +T A E+
Sbjct: 950 KDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEI 1009
Query: 204 QALRN-DLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNV--LLK 260
++ + K N ++L ++ ++ +++ +LN E + V +KHQ E+ ++ L
Sbjct: 1010 MNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMV--VKHQKELNDMQAQLV 1067
Query: 261 EEMKSYYELEM 271
EE EL+M
Sbjct: 1068 EECAHRNELQM 1078
Score = 43.5 bits (101), Expect = 3e-04
Identities = 68/328 (20%), Positives = 141/328 (42%), Gaps = 41/328 (12%)
Query: 24 EETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKR-KKYIFQLNEIEQEQNLREN 82
E+ +E + E + +E++ +S K + +K + + N++ + ++
Sbjct: 503 EQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAV 562
Query: 83 KRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDN----LPALLRQDIRKKFM 138
+ S E + + ES N ++ + N +NS TD L A+L + R +
Sbjct: 563 RLRKSHTEMSKSISQLESLNREL---QERNRILENSKSQTDKDYYQLQAILEAERRDRGH 619
Query: 139 ERM---SPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKE--IFTKPLNFQ--- 190
+ + + L EE++ L K+E E + A+ L H +KE LN++
Sbjct: 620 DSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKS 679
Query: 191 -----ETETDASKSDYELQALRNDLSEKATNVK--NLSEQLQQAKEVIHKLNLENR---- 239
E E + K ++ E+A +V + ++L++ +E K ENR
Sbjct: 680 LQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREK--AENRVVQI 737
Query: 240 ---------NLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKT 290
+LK++ +KL+H T GN E+ L++ + + +++NEL+T+
Sbjct: 738 EKQCSMLDVDLKQSQQKLEHLT--GNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQ-A 794
Query: 291 LQARNNRALELLRKYYASSMVTSSSILD 318
+A N + LE K ++++ + +L+
Sbjct: 795 FEADNLKGLEKQMKQEINTLLEAKRLLE 822
Score = 41.2 bits (95), Expect = 0.001
Identities = 53/224 (23%), Positives = 94/224 (41%), Gaps = 37/224 (16%)
Query: 82 NKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERM 141
N+R +S + N S SN D + +ES T N L+ ++ +K
Sbjct: 402 NRRYLSSANPNDNRTS---SNADKSLQESLQKTIYKLEEQLHN-EMQLKDEMEQKCR--- 454
Query: 142 SPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDY 201
+ + L+ + +EL+E + R +E EKE + + I ++Y
Sbjct: 455 TSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRI----------------NEY 498
Query: 202 ELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKE 261
+ +A + + EK NV+N L+ E + K++ ++ E + +L+ Q E N LL+
Sbjct: 499 QRKAEQEN--EKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRT 556
Query: 262 EMKSYYEL-----EMAKIRGELSVIKNELRTEKTLQARNNRALE 300
E + L EM+K +L + EL+ NR LE
Sbjct: 557 ESDTAVRLRKSHTEMSKSISQLESLNRELQ-------ERNRILE 593
Score = 31.2 bits (69), Expect = 1.3
Identities = 37/203 (18%), Positives = 80/203 (39%), Gaps = 36/203 (17%)
Query: 21 DVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLR 80
++ +E+ + S + Q D + + +S ++ +R+ E+ ++
Sbjct: 915 ELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRREN-----EELTEKMKKA 969
Query: 81 ENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLR---------- 130
E + + K E E SN+ E++ N+ T + + L ++
Sbjct: 970 EEEYKLEKEE--------EISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKK 1021
Query: 131 ---QDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPL 187
QD+RKK E+ + KL L ELN + K + +KEL + ++ +
Sbjct: 1022 ANTQDLRKK--EKENRKLQL--------ELNQEREKFNQMVVKHQKELNDMQAQLVEECA 1071
Query: 188 NFQETETDASKSDYELQALRNDL 210
+ E + + + +++ LR L
Sbjct: 1072 HRNELQMQLASKESDIEQLRAKL 1094
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 57.4 bits (137), Expect = 2e-08
Identities = 74/315 (23%), Positives = 128/315 (40%), Gaps = 43/315 (13%)
Query: 6 KHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKK 65
K N + P + ++V ++ + + + D K E+I QE K K K
Sbjct: 839 KKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN-------QEFVKIKDKN 891
Query: 66 YIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEE---SFNSTEDNSTCST 122
I + N + ++ +++++E +S S V + E ++ ++
Sbjct: 892 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLH 951
Query: 123 DNLPA------LLRQDIRKKFMERMSPKLCLNL-------LNEELEELNMKYRKIEEEFE 169
+ A +++ I+ K+ +S + C L ++L E KY EEE +
Sbjct: 952 AEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVK 1011
Query: 170 NAEKELLHYKKEIFTKPLNFQ----------ETETDASKSDYELQALRNDLSEKATNVKN 219
++E KKEIFT + + E E S+ EL DLS+K T VKN
Sbjct: 1012 KNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1071
Query: 220 LSEQL--QQAKEVIHKLNLENRNLK-----EAVRKLKHQTEVGNVLLKEEMKSY---YEL 269
+ E+L + AK+ L ++N K E V LK LKEE+KS YE
Sbjct: 1072 VKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEK 1131
Query: 270 EMAKIRGELSVIKNE 284
E + +++N+
Sbjct: 1132 EQQTVTKLHQLLENQ 1146
Score = 46.6 bits (109), Expect = 3e-05
Identities = 53/247 (21%), Positives = 103/247 (41%), Gaps = 35/247 (14%)
Query: 42 KGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISK--------NETDT 93
+ +++ N + +EE K ++ Y + + + L EN++N S E
Sbjct: 1105 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1164
Query: 94 NSASYESSNVDVTTEESFNSTEDNSTCSTD--NLPALLRQ-------DIRKKFMERMSPK 144
+++ EES N E+ S ++ N L++ D+ K + +
Sbjct: 1165 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1224
Query: 145 LCLNLLNEELEELNMKYRKIEEEFENA---------EKELLHY--------KKEIFTKPL 187
++ LNE+L LN KY ++ EE +A EKELLH+ +KE K L
Sbjct: 1225 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSL 1284
Query: 188 -NFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVR 246
E + +S +++A N ++E +V+ L + L ++ + + + +
Sbjct: 1285 TTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLID 1344
Query: 247 KLKHQTE 253
L+HQ +
Sbjct: 1345 TLQHQVK 1351
Score = 41.6 bits (96), Expect = 0.001
Identities = 53/258 (20%), Positives = 111/258 (43%), Gaps = 21/258 (8%)
Query: 28 EPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNIS 87
E E E++ ++ + E+ N+ ++ Q + ++ +L + E + + +
Sbjct: 639 EMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTL- 697
Query: 88 KNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCL 147
KN+T + + E++ N T + +P + +D++K S +
Sbjct: 698 KNQTLQKEIEKVYLDNKLLKEQAHNLTIE---MKNHYVPLKVSEDMKK------SHDAII 748
Query: 148 NLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETE-TDASKSDYELQAL 206
+ LN +L ++ KY + + E E L + + +K ++ ET K + E+ AL
Sbjct: 749 DDLNRKLLDVTQKYTE-----KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIAL 803
Query: 207 RNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSY 266
++++ E + L ++ + +E IH L EN NLK+ + + V EE+K
Sbjct: 804 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM-----SNQYVPVKTHEEVKMT 858
Query: 267 YELEMAKIRGELSVIKNE 284
+AK EL +K +
Sbjct: 859 LNDTLAKTNRELLDVKKK 876
Score = 41.6 bits (96), Expect = 0.001
Identities = 66/308 (21%), Positives = 135/308 (43%), Gaps = 47/308 (15%)
Query: 30 ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFK------RKKYIFQLNEIEQEQNLRENK 83
+ S+ + A+ KG EEI L + ++ + + KY ++ E E+ + +
Sbjct: 930 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATE 989
Query: 84 RNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKF------ 137
+ + + S ++ V+ EE + ++N + L++D+R K
Sbjct: 990 KELK------DQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKDLRDKTVLIEKS 1041
Query: 138 --MERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETD 195
MER + + LN++L++L+ KY +++ E +E EI Q+
Sbjct: 1042 HEMERALSRKT-DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1100
Query: 196 ASKSDYELQALR---NDLSEKATNVKNLSEQLQQAKEVIHKLNLENR-----------NL 241
+ + ++L +L E+ +++ E+ QQ +H+L LEN+ +
Sbjct: 1101 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL-LENQKNSSVPLAEHLQI 1159
Query: 242 KEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELR-TEKTLQARNNRALE 300
KEA K EVG ++K ++ E K+ E+S +++E++ T++ L+ R +
Sbjct: 1160 KEAFEK-----EVG--IIKASLREKEEESQNKME-EVSKLQSEVQNTKQALKKLETREVV 1211
Query: 301 LLRKYYAS 308
L KY A+
Sbjct: 1212 DLSKYKAT 1219
Score = 35.4 bits (80), Expect = 0.070
Identities = 48/244 (19%), Positives = 103/244 (42%), Gaps = 21/244 (8%)
Query: 58 ESKFKRKKYIFQLNEIEQEQNLR-----ENKRNISKNETDTNSASYESSNVDVTTEESFN 112
ES+ ++ K + E + E++LR +N+ +++ + + + + D+ ++
Sbjct: 329 ESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQM 388
Query: 113 STEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCL----NLLNEELEELNMKYRKIEEEF 168
D S C++ +PA ++ + +E P +L +ELE + +++
Sbjct: 389 YMAD-SQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDR 447
Query: 169 ENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAK 228
+ EL H E L + + D+ + +L+ D+ ++ + +Q+Q
Sbjct: 448 LKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ--- 504
Query: 229 EVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYE---LEMAKIRGELSVIKNEL 285
H L L+ EA TE LK ++K YE E+ K+R ++ +NE+
Sbjct: 505 --THFLALKEHLTSEAASGNHRLTEELKDQLK-DLKVKYEGASAEVGKLRNQIK--QNEM 559
Query: 286 RTEK 289
E+
Sbjct: 560 IVEE 563
Score = 30.8 bits (68), Expect = 1.7
Identities = 28/104 (26%), Positives = 51/104 (49%), Gaps = 12/104 (11%)
Query: 225 QQAKEVIHKLNLENRNLKEAVRKLKHQTEV-------GNVLLKEEMKSYYELEMAKIRGE 277
Q+ + I L +EN +LKE +RK++ + + + L EE+ +LE + + +
Sbjct: 277 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLK 336
Query: 278 LSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILDHFT 321
+ E + E++L R AL+ KY+ S + S S HF+
Sbjct: 337 SLLAAKEKQHEESL--RTIEALKNRFKYFESDHLGSGS---HFS 375
Score = 30.8 bits (68), Expect = 1.7
Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 16/160 (10%)
Query: 154 LEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYEL---------- 203
+EE K+ EE + +KEL + E K E E A + +L
Sbjct: 561 VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFE 620
Query: 204 ---QALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLK 260
+L N+++EKA + + + +++ I +L E N+K + + E V +
Sbjct: 621 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSR 680
Query: 261 EEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE 300
E KS E+ K EL++ L+ E +N+ L+
Sbjct: 681 LEQKSG---ELGKKITELTLKNQTLQKEIEKVYLDNKLLK 717
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 57.4 bits (137), Expect = 2e-08
Identities = 74/315 (23%), Positives = 128/315 (40%), Gaps = 43/315 (13%)
Query: 6 KHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKK 65
K N + P + ++V ++ + + + D K E+I QE K K K
Sbjct: 852 KKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN-------QEFVKIKDKN 904
Query: 66 YIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEE---SFNSTEDNSTCST 122
I + N + ++ +++++E +S S V + E ++ ++
Sbjct: 905 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLH 964
Query: 123 DNLPA------LLRQDIRKKFMERMSPKLCLNL-------LNEELEELNMKYRKIEEEFE 169
+ A +++ I+ K+ +S + C L ++L E KY EEE +
Sbjct: 965 AEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVK 1024
Query: 170 NAEKELLHYKKEIFTKPLNFQ----------ETETDASKSDYELQALRNDLSEKATNVKN 219
++E KKEIFT + + E E S+ EL DLS+K T VKN
Sbjct: 1025 KNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1084
Query: 220 LSEQL--QQAKEVIHKLNLENRNLK-----EAVRKLKHQTEVGNVLLKEEMKSY---YEL 269
+ E+L + AK+ L ++N K E V LK LKEE+KS YE
Sbjct: 1085 VKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEK 1144
Query: 270 EMAKIRGELSVIKNE 284
E + +++N+
Sbjct: 1145 EQQTVTKLHQLLENQ 1159
Score = 46.6 bits (109), Expect = 3e-05
Identities = 53/247 (21%), Positives = 103/247 (41%), Gaps = 35/247 (14%)
Query: 42 KGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISK--------NETDT 93
+ +++ N + +EE K ++ Y + + + L EN++N S E
Sbjct: 1118 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1177
Query: 94 NSASYESSNVDVTTEESFNSTEDNSTCSTD--NLPALLRQ-------DIRKKFMERMSPK 144
+++ EES N E+ S ++ N L++ D+ K + +
Sbjct: 1178 KEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1237
Query: 145 LCLNLLNEELEELNMKYRKIEEEFENA---------EKELLHY--------KKEIFTKPL 187
++ LNE+L LN KY ++ EE +A EKELLH+ +KE K L
Sbjct: 1238 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSL 1297
Query: 188 -NFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVR 246
E + +S +++A N ++E +V+ L + L ++ + + + +
Sbjct: 1298 TTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLID 1357
Query: 247 KLKHQTE 253
L+HQ +
Sbjct: 1358 TLQHQVK 1364
Score = 41.6 bits (96), Expect = 0.001
Identities = 53/258 (20%), Positives = 111/258 (43%), Gaps = 21/258 (8%)
Query: 28 EPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNIS 87
E E E++ ++ + E+ N+ ++ Q + ++ +L + E + + +
Sbjct: 652 EMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTL- 710
Query: 88 KNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCL 147
KN+T + + E++ N T + +P + +D++K S +
Sbjct: 711 KNQTLQKEIEKVYLDNKLLKEQAHNLTIE---MKNHYVPLKVSEDMKK------SHDAII 761
Query: 148 NLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETE-TDASKSDYELQAL 206
+ LN +L ++ KY + + E E L + + +K ++ ET K + E+ AL
Sbjct: 762 DDLNRKLLDVTQKYTE-----KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIAL 816
Query: 207 RNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSY 266
++++ E + L ++ + +E IH L EN NLK+ + + V EE+K
Sbjct: 817 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM-----SNQYVPVKTHEEVKMT 871
Query: 267 YELEMAKIRGELSVIKNE 284
+AK EL +K +
Sbjct: 872 LNDTLAKTNRELLDVKKK 889
Score = 41.6 bits (96), Expect = 0.001
Identities = 66/308 (21%), Positives = 135/308 (43%), Gaps = 47/308 (15%)
Query: 30 ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFK------RKKYIFQLNEIEQEQNLRENK 83
+ S+ + A+ KG EEI L + ++ + + KY ++ E E+ + +
Sbjct: 943 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATE 1002
Query: 84 RNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKF------ 137
+ + + S ++ V+ EE + ++N + L++D+R K
Sbjct: 1003 KELK------DQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT--LQKDLRDKTVLIEKS 1054
Query: 138 --MERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETD 195
MER + + LN++L++L+ KY +++ E +E EI Q+
Sbjct: 1055 HEMERALSRKT-DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1113
Query: 196 ASKSDYELQALR---NDLSEKATNVKNLSEQLQQAKEVIHKLNLENR-----------NL 241
+ + ++L +L E+ +++ E+ QQ +H+L LEN+ +
Sbjct: 1114 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL-LENQKNSSVPLAEHLQI 1172
Query: 242 KEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELR-TEKTLQARNNRALE 300
KEA K EVG ++K ++ E K+ E+S +++E++ T++ L+ R +
Sbjct: 1173 KEAFEK-----EVG--IIKASLREKEEESQNKME-EVSKLQSEVQNTKQALKKLETREVV 1224
Query: 301 LLRKYYAS 308
L KY A+
Sbjct: 1225 DLSKYKAT 1232
Score = 35.4 bits (80), Expect = 0.070
Identities = 48/244 (19%), Positives = 103/244 (42%), Gaps = 21/244 (8%)
Query: 58 ESKFKRKKYIFQLNEIEQEQNLR-----ENKRNISKNETDTNSASYESSNVDVTTEESFN 112
ES+ ++ K + E + E++LR +N+ +++ + + + + D+ ++
Sbjct: 342 ESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQM 401
Query: 113 STEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCL----NLLNEELEELNMKYRKIEEEF 168
D S C++ +PA ++ + +E P +L +ELE + +++
Sbjct: 402 YMAD-SQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDR 460
Query: 169 ENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAK 228
+ EL H E L + + D+ + +L+ D+ ++ + +Q+Q
Sbjct: 461 LKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ--- 517
Query: 229 EVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYE---LEMAKIRGELSVIKNEL 285
H L L+ EA TE LK ++K YE E+ K+R ++ +NE+
Sbjct: 518 --THFLALKEHLTSEAASGNHRLTEELKDQLK-DLKVKYEGASAEVGKLRNQIK--QNEM 572
Query: 286 RTEK 289
E+
Sbjct: 573 IVEE 576
Score = 30.8 bits (68), Expect = 1.7
Identities = 28/104 (26%), Positives = 51/104 (49%), Gaps = 12/104 (11%)
Query: 225 QQAKEVIHKLNLENRNLKEAVRKLKHQTEV-------GNVLLKEEMKSYYELEMAKIRGE 277
Q+ + I L +EN +LKE +RK++ + + + L EE+ +LE + + +
Sbjct: 290 QREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLK 349
Query: 278 LSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILDHFT 321
+ E + E++L R AL+ KY+ S + S S HF+
Sbjct: 350 SLLAAKEKQHEESL--RTIEALKNRFKYFESDHLGSGS---HFS 388
Score = 30.8 bits (68), Expect = 1.7
Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 16/160 (10%)
Query: 154 LEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYEL---------- 203
+EE K+ EE + +KEL + E K E E A + +L
Sbjct: 574 VEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFE 633
Query: 204 ---QALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLK 260
+L N+++EKA + + + +++ I +L E N+K + + E V +
Sbjct: 634 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSR 693
Query: 261 EEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE 300
E KS E+ K EL++ L+ E +N+ L+
Sbjct: 694 LEQKSG---ELGKKITELTLKNQTLQKEIEKVYLDNKLLK 730
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 57.4 bits (137), Expect = 2e-08
Identities = 63/268 (23%), Positives = 126/268 (47%), Gaps = 32/268 (11%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNL 79
+D+ +E +++ T D + +++I ++ SKF + K +++++QE +
Sbjct: 395 RDLEDEIQMLKANGVLNTEDREEEIKQI-----EVYKSHSKFMKTK----IDQLKQELSK 445
Query: 80 RENKRNI--SKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPAL-LRQDIRKK 136
+E++ +K ET +N S +++V +ES + E + + AL LR + ++
Sbjct: 446 KESELLALQTKLETLSNQNSDCKQHIEVL-KESLTAKEQRAAILQTEVDALRLRLEEKES 504
Query: 137 FMERMSPKL---------CLNLLNEELEELNMKYRKI---EEEFENAEKELLHYKKEIFT 184
F+ + + +L + + + L +K RKI +++ EN +++L K++
Sbjct: 505 FLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTN 564
Query: 185 KPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQ----QAKEVIHKLNLENRN 240
+ +TD+S +D L L LSEK ++ L EQ + + E I EN++
Sbjct: 565 LKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKD 624
Query: 241 LKEAVRKLK---HQTEVGNVLLKEEMKS 265
LKE V L+ + E + LKE S
Sbjct: 625 LKEKVNALQAELTEKESSLIDLKEHASS 652
Score = 40.8 bits (94), Expect = 0.002
Identities = 47/244 (19%), Positives = 103/244 (42%), Gaps = 13/244 (5%)
Query: 25 ETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIE---QEQNLRE 81
+ S E +Q ++ EE++ S + E +K K + + ++ + + E+N+R+
Sbjct: 338 QVSHLEVILDQKEKENIHLREELHRRSQLQ-PEPAKTKALQTVIEMKDTKIASLERNIRD 396
Query: 82 NKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERM 141
+ I + + + E ++ E + S D L +Q++ KK E +
Sbjct: 397 LEDEIQMLKAN-GVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL----KQELSKKESELL 451
Query: 142 SPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDY 201
+ + L L+ + + ++E E+ + E+ L +E E+ +K
Sbjct: 452 ALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTK 511
Query: 202 ELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKE 261
+LQ L + A ++++ + L+ + I+ L + NL+E +R Q LK+
Sbjct: 512 QLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQL----TNLKD 567
Query: 262 EMKS 265
+KS
Sbjct: 568 RVKS 571
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 55.8 bits (133), Expect = 5e-08
Identities = 65/290 (22%), Positives = 126/290 (43%), Gaps = 48/290 (16%)
Query: 24 EETSEPESSSEQTTADSSKGMEEIYN-------LSSRKFQEESKFKRKKYIFQLNEIEQE 76
EE +++ QTT + + E+I +S RK Q E + + Q+ ++ E
Sbjct: 1407 EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELR------QVTQMRTE 1460
Query: 77 QNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNST-CSTDNLPALLR--QDI 133
+++R K D + + + N ++ + E N C D L R D+
Sbjct: 1461 ESVRY------KQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDL 1514
Query: 134 RKKFMERMSPKLCLNLLNEELEELNMKYRKIEEE----------FENAEKELLHYKKEIF 183
+K L + +EL L + Y ++ +E F+N+ KEL K+++
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVE 1574
Query: 184 TKPLNFQETETDAS----KSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENR 239
+ + T ++ S K + EL+ +R L E+A + NL++QL+QA V
Sbjct: 1575 EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV--------- 1625
Query: 240 NLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEK 289
K + L+ Q +V + L+E+ ++ EL ++ E+ ++ +L E+
Sbjct: 1626 -KKRSEDDLRQQRDVLDGHLREKQRTQEELR--RLSSEVEALRRQLLQEQ 1672
Score = 48.1 bits (113), Expect = 1e-05
Identities = 69/303 (22%), Positives = 124/303 (40%), Gaps = 67/303 (22%)
Query: 49 NLSSRKFQEESKFKRKKY-IFQLNEIEQEQNLRENK--------RNISKNETDTNSASYE 99
NL +K + E K K+Y I +L + QE+ R+ + RN E YE
Sbjct: 1152 NLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYE 1211
Query: 100 SS-NVDVTT-EESFNSTEDNSTCSTDNLPALLRQ--DIRKKFME---------------- 139
+ N+ TT +E ED+S + L L R+ D++ + +
Sbjct: 1212 TEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE 1271
Query: 140 --RMSPKLCLNLLNEELEELNMKYRKI-----------EEEFENAEKELLHYKKEIFTKP 186
+ K C + + ++ + L ++ +++ ++ E A K + KEI
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
Query: 187 LNFQETETDASKSDYELQALRNDLSEKATNVKNLSE-QLQQAKEVIHKLNL--------- 236
FQE + + EL +RN+ E+ ++KN E ++ K IH+L +
Sbjct: 1332 AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGY 1391
Query: 237 ---------ENRNLKEAVRKLKHQ-TEVGNVLLKEEMKSYYELEMAKIRG-ELSVIKNEL 285
ENR+L E +++LK+ T+ L + E +++ K G E+S K +L
Sbjct: 1392 RAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVE----EDIQQQKATGSEVSQRKQQL 1447
Query: 286 RTE 288
E
Sbjct: 1448 EVE 1450
Score = 36.6 bits (83), Expect = 0.031
Identities = 59/321 (18%), Positives = 126/321 (39%), Gaps = 45/321 (14%)
Query: 22 VLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRE 81
++++ SE + ++ D ++ R+ E + R++ + + ++Q E
Sbjct: 1624 IVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNE 1683
Query: 82 N-KRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTD--NLPALLRQDIRKKFM 138
+ ++ I N + E + TE N T+++ + NL L D+R+
Sbjct: 1684 HFQKAIEDKSRSLNESKIEIERLQSLTE---NLTKEHLMLEEELRNL-RLEYDDLRRGRS 1739
Query: 139 ERMSPKLC--------LNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQ 190
E S K L + N EL ++ E EN +E+ ++K+ Q
Sbjct: 1740 EADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQ 1799
Query: 191 ETETDASKSDYELQALR---NDLSEKATNVKNLSEQLQQAKEVIH-------KLNLENRN 240
E++ ++ E ++L L + ++ L ++L +AK + +L E +
Sbjct: 1800 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1859
Query: 241 LK--------------EAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELR 286
++ EA+RK++ + E E K+ E+ +++ E+ I+ R
Sbjct: 1860 IQNDLNQWKTQYSRKEEAIRKIESERE-----KSEREKNSLRSEIERLQAEIKRIEERCR 1914
Query: 287 TEKTLQARNNRA-LELLRKYY 306
+ R ++ LE R Y
Sbjct: 1915 RKLEDSTRETQSQLETERSRY 1935
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 55.1 bits (131), Expect = 8e-08
Identities = 79/327 (24%), Positives = 147/327 (44%), Gaps = 53/327 (16%)
Query: 9 KENMFTPFFSAQDVLEETSEPESSSEQTTADSSKG--MEEIYN--------LSSRKFQEE 58
+E T QD L E + E S + + D KG +EE+ L +++ QE+
Sbjct: 693 REQHQTEIRDLQDQLSEMHD-ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 59 SKFKRKKYIFQLN-EIEQEQNLRENKRNISKNETDTN------SASYESSNVDVTTEESF 111
KR++ + L +++E + + + + K + D S + NV+V S
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 112 NSTEDNSTCSTDNLPALLRQDIRK-----KFMERMSPKLCLNLLNEELEELNMK--YRKI 164
S +D + T+ LL+++ K + +ER +L + + + +E K +K
Sbjct: 812 TSEQDQA--GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKY 869
Query: 165 EEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQL 224
E E E+ L+H +KE +E + + EL+A + +LS+ K LSE+L
Sbjct: 870 EGEIRQLEEALVHARKEE-------KEAVSARRALENELEAAQGNLSQTTQEQKQLSEKL 922
Query: 225 Q---QAKEVIHKLNLENRN----LKEAVRKLKHQ-------TEVGNVLLKEEMKSYYELE 270
+ + KE + +L E N L + + KL+ + + + L+ ++ Y E
Sbjct: 923 KEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE-- 980
Query: 271 MAKIRGELSVIKNELRTEKTLQARNNR 297
K R EL+ ++ +L+ EKTL+A +R
Sbjct: 981 --KNRRELAEMQRQLK-EKTLEAEKSR 1004
Score = 45.8 bits (107), Expect = 5e-05
Identities = 68/315 (21%), Positives = 138/315 (43%), Gaps = 54/315 (17%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRK-KYIFQLNEIEQEQN 78
Q++ EE ++ E+ + ++ +EE L R + E + ++ + +FQ+ ++E+EQ+
Sbjct: 638 QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQV-KMEREQH 696
Query: 79 ---LRENKRNISKNETDTNSAS-YESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQD-- 132
+R+ + +S+ + +SA E EE + +D D L A Q+
Sbjct: 697 QTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQD----LQDLLIAKEEQEDL 752
Query: 133 IRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQET 192
+RK+ E + K L EE+ + + K++E+++ AE + L E TK + +
Sbjct: 753 LRKRERELTALK---GALKEEVSSHDQEMDKLKEQYD-AELQALRESVEEATKNVEVLAS 808
Query: 193 ETDASKSDY---------------ELQALRNDLSEKATNVKNLSEQLQ----QAKEVIHK 233
++ S+ D +LQ +L + ++ E L+ +AKE + K
Sbjct: 809 RSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKK 868
Query: 234 LNLENRNLKEAV--------------RKLKHQTEVGNVLLKEEMKSYYEL-----EMAKI 274
E R L+EA+ R L+++ E L + + +L E ++
Sbjct: 869 YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ 928
Query: 275 RGELSVIKNELRTEK 289
+ +L +KNE+ E+
Sbjct: 929 KEQLRRLKNEMENER 943
Score = 37.4 bits (85), Expect = 0.018
Identities = 63/302 (20%), Positives = 117/302 (38%), Gaps = 61/302 (20%)
Query: 29 PESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISK 88
P +S+ Q T D KG +E+ Q NE +Q L + +
Sbjct: 528 PSASNTQATPDLLKGQQELTQ-------------------QTNEETAKQILYNY---LKE 565
Query: 89 NETDTNSASYESSNVDVTTEESFNSTE------DNSTC-STDNLPALLRQDIRKKF-MER 140
TD + A+ N+ ++ S +N C ST + LL Q + +
Sbjct: 566 GSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE 625
Query: 141 MSPKLCLNLLNEE-LEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKS 199
+ +L L + N++ ++E + R EE + E + +E T +E+E + K+
Sbjct: 626 LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKV---EENSTLQQRLEESEGELRKN 682
Query: 200 DYELQALRNDLSEKATNVKNLSEQLQ-------------------------QAKEVIHKL 234
EL ++ + + T +++L +QL QAK+ + L
Sbjct: 683 LEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL 742
Query: 235 NLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQAR 294
+ ++ +RK + + LKEE+ S ++ EM K++ + LR E +A
Sbjct: 743 LIAKEEQEDLLRKRERELTALKGALKEEVSS-HDQEMDKLKEQYDAELQALR-ESVEEAT 800
Query: 295 NN 296
N
Sbjct: 801 KN 802
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 54.3 bits (129), Expect = 1e-07
Identities = 75/337 (22%), Positives = 136/337 (40%), Gaps = 60/337 (17%)
Query: 22 VLEETSEPESSSEQTTADS----SKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQ 77
VLE+ + ++ DS S+G+ +Y S+ ++E K K+ K + ++E
Sbjct: 76 VLEQVGNSDCHYQEGLKDSDLENSEGLSRVY---SKLYKEAEKIKKWKVSTEAELRQKES 132
Query: 78 NLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTED--NSTCSTDNLPALLRQDI-- 133
L+EN++ I + + V + EE +D +T +L LL++
Sbjct: 133 KLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCAR 192
Query: 134 -----RKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKEL------------- 175
+K ER + LN +E++ + ++ + EN+ E+
Sbjct: 193 SAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQH 252
Query: 176 --LHYKKEIFTKP-----LNFQETETDASKSD--YELQALRNDLSEKATNVKNLSEQLQQ 226
YKKEI K L Q TE + D + L+ R+ +++ K SE L+Q
Sbjct: 253 LEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQ 312
Query: 227 AKEVIHKLNLENRNLKEAVRK-------LKHQTEVGN---VLLKEEMKSYYELEMAKIRG 276
+ E H L E ++K ++++ L+ ++ L EE ++ E E K R
Sbjct: 313 SIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQME-ESNKARA 371
Query: 277 ELSVIKNE-----------LRTEKTLQARNNRALELL 302
S + E LRTE+ +N L++L
Sbjct: 372 AHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
Score = 48.5 bits (114), Expect = 8e-06
Identities = 57/273 (20%), Positives = 108/273 (39%), Gaps = 33/273 (12%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKF----------QEESKFKRKKYIFQ 69
Q L + E S Q + + K +EE ++++ EES R + F
Sbjct: 317 QHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFV 376
Query: 70 LNEIEQ-----EQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDN 124
+ E E E+ LR ++ + KNE + E EE T +N +
Sbjct: 377 VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLT-NNKEVELEE 435
Query: 125 LPALLRQD----IRKKFMERMSPKL---------CLNLLNEELEELNMKYRKIEEEFENA 171
L +L + K E+++ +L L +E+ +L ++ I +
Sbjct: 436 LKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 172 EKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVI 231
KE+ K E+ + L E + +K E + L + S+ +KN E + K+
Sbjct: 496 SKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQE 555
Query: 232 HKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMK 264
++ + NL+E +L+++ E ++EE+K
Sbjct: 556 ERMLKQIENLQETETQLRNELE----YVREELK 584
Score = 30.8 bits (68), Expect = 1.7
Identities = 60/276 (21%), Positives = 113/276 (40%), Gaps = 45/276 (16%)
Query: 20 QDVLEETSEP--ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQ 77
+++ +ETS+ E ++Q +++K EE QE R + + E++Q++
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 78 NLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIR--K 135
+ E K + K+E + N+ + N + EE + T L +I+ K
Sbjct: 588 D--EVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNK 645
Query: 136 KFMERMSPKLCLNLLNE----ELEELNMKYRKIEEEFENAE---KELLHYKKEI------ 182
+E S K + + E+E+ + + EE E A+ E + +KEI
Sbjct: 646 LELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQH 705
Query: 183 ---------------FTKPLNFQETETDASKS-DYELQALRNDLSEKATNVKNLSEQLQQ 226
+ K + +++E KS + E +LR L + +N+K +E L
Sbjct: 706 KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLK--AELLSV 763
Query: 227 AKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEE 262
K+ L +E +E KLK + + LKE+
Sbjct: 764 KKQ----LEIE----REEKEKLKREAKENTATLKEK 791
>gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
Length = 541
Score = 53.1 bits (126), Expect = 3e-07
Identities = 65/292 (22%), Positives = 133/292 (45%), Gaps = 39/292 (13%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLREN 82
L E + E + S + + + K QE+ K ++ + +E++L E
Sbjct: 261 LLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR-PREESLAE- 318
Query: 83 KRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPAL------LRQDIRKK 136
K+ S+ + D +S N T+E+ + TC +L ++ L Q++ +K
Sbjct: 319 KKYTSQGQGDLDSV-LSQLNFTHTSEDLLQA---EVTCLEGSLESVSATCKQLSQELMEK 374
Query: 137 FMERMSPKLCLNLLNEELEELNMKYRKIEEEFENA----EKELLHYKKEIFTKPLNFQET 192
+ E + N E+++L + + E+ + +A + E+ H +E+ + + T
Sbjct: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
Query: 193 ETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLK--- 249
+ +S + L+A +KA K + +QL+ L LENR+L E V KL+
Sbjct: 435 KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE-------SLKLENRHLSEMVMKLELGL 487
Query: 250 HQ-----TEVGNV----LLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQ 292
H+ + +G++ L +EE++S++ LE ++ + +K E +EKT++
Sbjct: 488 HECSLPVSPLGSIATRFLEEEELRSHHILE--RLDAHIEELKRE--SEKTVR 535
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 52.8 bits (125), Expect = 4e-07
Identities = 45/229 (19%), Positives = 102/229 (44%), Gaps = 13/229 (5%)
Query: 38 ADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLR----ENKRNISKNETDT 93
A+ ++G+ E NL + + E R+KY+ +L + + R + + + E +
Sbjct: 1448 AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEV 1507
Query: 94 NSASYESSNVDVTTE-ESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNE 152
+A YE + V V E + F T + L R+ ++ +E +S KL +
Sbjct: 1508 MTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ--VEELSKKLADSDQAS 1565
Query: 153 ELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSE 212
++++ K + ++ + +++E + ++ L Q ++ + + Y+LQ +
Sbjct: 1566 KVQQ--QKLKAVQAQGGESQQEAQRLQAQL--NELQAQLSQKEQAAEHYKLQMEKAKTHY 1621
Query: 213 KATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKE 261
A +N ++LQ+ + +L EN+ L+ +L H+ + + KE
Sbjct: 1622 DAKKQQN--QELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKE 1668
Score = 38.1 bits (87), Expect = 0.011
Identities = 62/288 (21%), Positives = 107/288 (37%), Gaps = 19/288 (6%)
Query: 39 DSSKGMEEIYNLSSRKFQEESKFKRKKYIFQL-NEIEQEQNLRENKRNISKNETDTNSAS 97
++ +G +E L+ R EE K + I L + I +E S+ +A
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499
Query: 98 YESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEE- 156
S ++TT + +D + + + ++ L E+L
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSS 559
Query: 157 LNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATN 216
L K ++++E E E + +++ T +E E + D L+ L EKA
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAA---EEREASLRERDAALKQLEALEKEKAAK 616
Query: 217 VKNLSEQLQQAKEV-------IHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYEL 269
++ L +QLQ A E + + E L V +L+ E E EL
Sbjct: 617 LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL 676
Query: 270 EMAKIRGELSVIKNELRTEKTLQARNNRAL-ELLRKYYASSMVTSSSI 316
E+ ++R E + TEK A+ L E L+ S VT S+
Sbjct: 677 EL-QLRSE-----QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL 718
Score = 38.1 bits (87), Expect = 0.011
Identities = 58/278 (20%), Positives = 107/278 (38%), Gaps = 30/278 (10%)
Query: 69 QLNEIEQ-EQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTED--------NST 119
Q+ E+E+ Q +++ K ++K E + S S S TE + E
Sbjct: 1076 QIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135
Query: 120 CSTDNLPA-LLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHY 178
C A L + + + R L L +LEE + + +A++EL +
Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195
Query: 179 KKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQL-------QQAKEVI 231
+ ++ E + ++ E + + +S V L+ Q+ ++ K ++
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
Query: 232 HKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELS---VIKNELRTE 288
+ +++ L+E +R L+ +T N E S E+ +R E V LR E
Sbjct: 1256 MAESEKSQKLEERLRLLQAET-ASNSARAAERSSALREEVQSLREEAEKQRVASENLRQE 1314
Query: 289 KTLQARNNRALEL-------LRKYYASSMVTSSSILDH 319
T QA RA EL K++ S+ L+H
Sbjct: 1315 LTSQA--ERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350
Score = 28.5 bits (62), Expect = 8.5
Identities = 49/315 (15%), Positives = 118/315 (37%), Gaps = 25/315 (7%)
Query: 24 EETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESK------------FKRKKYIFQLN 71
+E E +E T + +++ +L + K Q + K FK +++ L
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 72 EIEQEQNLRENKRNISKNETDTNSASYE----SSNVDVTTEESFNSTEDNSTCSTDNLPA 127
+++ N + + + E A E ++ D E N + +
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 128 LLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPL 187
L+ + ++ E + L L L +E L +++ E E E + ++ +
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Query: 188 NFQETETDASKSDYELQALRNDLSEKATNVKNLSE--------QLQQAKEVIHKLNLENR 239
+F+E + S +LQ+ ++LS+ ++ S+ Q+ + LN +
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515
Query: 240 NLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRAL 299
+ + LK Q + L + ++ + +R ++ + + L+ ++
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG-LRHQVEQLSSSLKQKEQQLKEVAEKQ 574
Query: 300 ELLRKYYASSMVTSS 314
E R+ +A + T++
Sbjct: 575 EATRQDHAQQLATAA 589
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 52.8 bits (125), Expect = 4e-07
Identities = 54/284 (19%), Positives = 126/284 (44%), Gaps = 34/284 (11%)
Query: 39 DSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKN----ETDTN 94
+ +G E+ S+ E ++++ K ++ + I++ + L E K+ +++ E
Sbjct: 1352 EEQEGKAELQRALSKANSEVAQWRTK---YETDAIQRTEELEEAKKKLAQRLQEAEEHVE 1408
Query: 95 SASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEEL 154
+ + + ++++ T + N ED + A D +++ +++ L
Sbjct: 1409 AVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKV------------L 1456
Query: 155 EELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKA 214
E KY + + E E ++KE E+F K N E D +L+ LR +
Sbjct: 1457 SEWKQKYEETQAELEASQKESRSLSTELF-KVKNVYEESLD------QLETLRRENKNLQ 1509
Query: 215 TNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKI 274
+ +L+EQ+ + + IH+L + +++ +++ E L+ E E ++ +I
Sbjct: 1510 QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHE-----EGKILRI 1564
Query: 275 RGELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILD 318
+ EL+ +K+E+ + A + ++ L++ + + T S LD
Sbjct: 1565 QLELNQVKSEVDRK---IAEKDEEIDQLKRNHTRVVETMQSTLD 1605
Score = 47.0 bits (110), Expect = 2e-05
Identities = 49/175 (28%), Positives = 85/175 (48%), Gaps = 27/175 (15%)
Query: 148 NLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQET---------ETDASK 198
NLL E+EEL + E + AE+ELL + + + L+ Q T E D S+
Sbjct: 1682 NLLQAEIEELWATLEQTERSRKIAEQELLDASERV--QLLHTQNTSLINTKKKLENDVSQ 1739
Query: 199 SDYELQAL---RNDLSEKA----TNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQ 251
E++ + + EKA T+ ++E+L++ ++ L +NL++ V+ L+H+
Sbjct: 1740 LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1799
Query: 252 -TEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELLRKY 305
E + LK K +LE A++R ++NE Q RN A++ LRK+
Sbjct: 1800 LDEAEQLALKGGKKQIQKLE-ARVRELEGEVENE-------QKRNAEAVKGLRKH 1846
Score = 44.7 bits (104), Expect = 1e-04
Identities = 63/273 (23%), Positives = 119/273 (43%), Gaps = 37/273 (13%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLREN 82
LE+T +EQ D+S+ ++ ++ ++ + K + N++ Q Q+ E
Sbjct: 1695 LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE--------NDVSQLQS--EV 1744
Query: 83 KRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERM- 141
+ I ++ A ++ + EE E +++ + + L Q + K R+
Sbjct: 1745 EEVIQESRNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLERMKKNLEQTV-KDLQHRLD 1801
Query: 142 -SPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLH-----YKKEIFTKPLNFQETETD 195
+ +L L +++++L + R++E E EN +K K E K L +Q TE D
Sbjct: 1802 EAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQ-TEED 1860
Query: 196 ASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVG 255
K+ LQ L + L K VK+ Q ++A+E N NL + RKL+H+ E
Sbjct: 1861 -RKNVLRLQDLVDKLQAK---VKSYKRQAEEAEE------QSNANLSK-FRKLQHELEEA 1909
Query: 256 NVLLKEEMKSYYELEMAKIRGELSVIKNELRTE 288
EE E ++ K+R + + ++ E
Sbjct: 1910 -----EERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 35.8 bits (81), Expect = 0.053
Identities = 63/329 (19%), Positives = 121/329 (36%), Gaps = 48/329 (14%)
Query: 24 EETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEES---KFKRKKYIFQLNEIEQEQNLR 80
E T + E+ +Q K EI NL S+ E++ + ++K Q E + +
Sbjct: 1067 ESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE 1126
Query: 81 ENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPAL--LRQDIRKKFM 138
+ + +K E + S E + EE+ +T + LR+D+ + +
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATL 1186
Query: 139 ERMSPKLCLNL--------LNEELEELNMKYRKIEEEFENAEKEL--LHYKKEIFTKPL- 187
+ + L L E+++ L +K+E+E + E L E +K
Sbjct: 1187 QHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKG 1246
Query: 188 -------NFQETETDASKSDYELQALRNDLSEKA----TNVKNLSEQLQQAKEVIHKLNL 236
+ ++ ++ + E Q L NDL+ + T S QL + ++ +L+
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306
Query: 237 ENRNLKEAVRKLKHQ----TEVGNVLL-----------------KEEMKSYYELEMAKIR 275
+ + + +LKHQ T+ N L +EE + EL+ A +
Sbjct: 1307 SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 276 GELSVIKNELRTEKTLQARNNRALELLRK 304
V + + E R E +K
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKK 1395
Score = 35.4 bits (80), Expect = 0.070
Identities = 58/295 (19%), Positives = 115/295 (38%), Gaps = 18/295 (6%)
Query: 6 KHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFK--- 62
KHW FF + +L+ ++E E + K +E+ +++ + E K
Sbjct: 828 KHWP--WMKLFFKIKPLLK-SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLL 884
Query: 63 RKKYIFQL---NEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNST 119
++K QL +E + + E + KN+ + E + EE N+
Sbjct: 885 KEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTE-RAEEEEEINAELTAKK 943
Query: 120 CSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYK 179
++ + L++DI +L L + +E K + + EE ++ +
Sbjct: 944 RKLEDECSELKKDIDDL-------ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLS 996
Query: 180 KEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENR 239
KE Q+T D + ++ L ++ V +L L+Q K++ L R
Sbjct: 997 KEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKR 1056
Query: 240 NLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQAR 294
L E KL ++ + K+++ E + +I +S I++E E LQ +
Sbjct: 1057 KL-EGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKK 1110
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 52.4 bits (124), Expect = 6e-07
Identities = 42/174 (24%), Positives = 82/174 (47%), Gaps = 23/174 (13%)
Query: 152 EELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLS 211
+EL+ LN + ++ E N E++L +E E + E+Q L++++
Sbjct: 333 KELDTLNNEIVDLQREKNNVEQDL--------------KEKEDTIKQRTSEVQDLQDEVQ 378
Query: 212 EKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLL---------KEE 262
+ TN++ L Q QQ +E++ +L+ + L+E +++++ + L+ +E
Sbjct: 379 RENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQES 438
Query: 263 MKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSI 316
S YE E+AK R ELS ++ E + LE L+++ S SS+
Sbjct: 439 QISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSM 492
Score = 37.7 bits (86), Expect = 0.014
Identities = 22/122 (18%), Positives = 57/122 (46%)
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRND 209
L +E++ N +K++ + + ++ L ++ +E ++ + +L+ +
Sbjct: 373 LQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAE 432
Query: 210 LSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYEL 269
L+ + + + E+L +A+E + +L E L+E+V K Q E L++ + +
Sbjct: 433 LTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSM 492
Query: 270 EM 271
+M
Sbjct: 493 QM 494
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 52.0 bits (123), Expect = 7e-07
Identities = 61/302 (20%), Positives = 132/302 (43%), Gaps = 44/302 (14%)
Query: 21 DVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLR 80
D+L E E E ++ A+ +GM S+ E ++++ K ++ + I++ + L
Sbjct: 1345 DLLREQYEEE---QEAKAELQRGM-------SKANSEVAQWRTK---YETDAIQRTEELE 1391
Query: 81 ENKRNISKN----ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKK 136
E K+ +++ E + + + ++++ T + N ED + A + D +++
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR 1451
Query: 137 FMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDA 196
+++ L E KY + + E E ++KE E+F K N E D
Sbjct: 1452 NFDKV------------LAEWKQKYEETQAELEASQKESRSLSTELF-KVKNAYEESLD- 1497
Query: 197 SKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGN 256
L+ L+ + + +L+EQ+ + + IH+L + L +L+ E
Sbjct: 1498 -----HLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAE 1552
Query: 257 VLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSI 316
L+ E E ++ +I+ EL+ +K+E+ + A + L+ L++ + + + S
Sbjct: 1553 ASLEHE-----EGKILRIQLELNQVKSEIDRK---IAEKDEELDQLKRNHLRVVESMQST 1604
Query: 317 LD 318
LD
Sbjct: 1605 LD 1606
Score = 42.0 bits (97), Expect = 7e-04
Identities = 72/320 (22%), Positives = 134/320 (41%), Gaps = 51/320 (15%)
Query: 25 ETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRK-----KYIFQLNE------- 72
E SE ++S E+ A +I + Q +S+ RK + + QL
Sbjct: 1540 EKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVE 1599
Query: 73 -----IEQEQNLRENKRNISKN-ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNL- 125
++ E R + I K E D N + ++ + E+ + + D
Sbjct: 1600 SMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQL 1659
Query: 126 ---PALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEI 182
A+ QD K+ + + + NL+ E+EEL + E + AE+ELL + +
Sbjct: 1660 HLDDAIRGQDDLKEQLAMVERRA--NLMQAEVEELRASLERTERGRKMAEQELLDASERV 1717
Query: 183 FTKPLNFQET---------ETDASKSDYELQAL---RNDLSEKA----TNVKNLSEQLQQ 226
+ L+ Q T ETD S+ E++ + + EKA T+ ++E+L++
Sbjct: 1718 --QLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 227 AKEVIHKLNLENRNLKEAVRKLK-HQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNEL 285
++ L +N+++ V+ L+ E + LK K +LE A++R S +++E
Sbjct: 1776 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE-ARVRELESEVESE- 1833
Query: 286 RTEKTLQARNNRALELLRKY 305
Q N A++ LRK+
Sbjct: 1834 ------QKHNVEAVKGLRKH 1847
Score = 38.5 bits (88), Expect = 0.008
Identities = 62/315 (19%), Positives = 116/315 (36%), Gaps = 50/315 (15%)
Query: 24 EETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEES---KFKRKKYIFQLNEIEQEQNLR 80
E T + E+ +Q K E+ NL + E++ + ++K Q E E+ +
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127
Query: 81 ENKRNISKNETDTNSASYESSNVDVTTEESFNSTE--------------------DNSTC 120
+ + +K E + S E + EE+ +T + ST
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTL 1187
Query: 121 STDNLPALLRQDIRKKFMERMSPKLCLNLLNEELE----ELNMKYRKIEEEFENAEKELL 176
+ A LR+ E L + ++LE EL M+ + E K
Sbjct: 1188 QHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKA 1247
Query: 177 HYKK----------EIFTKPLNFQE--TETDASKSDYELQA--LRNDLSEKATNVKNLS- 221
+++K EI TK Q E A K+ ++ L EK V LS
Sbjct: 1248 NFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 222 ------EQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELE--MAK 273
+Q+++ K + + L A++ +H ++ +EE ++ EL+ M+K
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Query: 274 IRGELSVIKNELRTE 288
E++ + + T+
Sbjct: 1368 ANSEVAQWRTKYETD 1382
Score = 33.1 bits (74), Expect = 0.35
Identities = 41/187 (21%), Positives = 84/187 (44%), Gaps = 17/187 (9%)
Query: 128 LLRQDIRKKFMERMSPKLCLN-----LLNEELEELNMKYRKIEEEFENAE--KELLHYKK 180
L+R + RK MER C+ +N + Y KI+ ++AE KE+ + K+
Sbjct: 800 LMRVEFRK-MMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKE 858
Query: 181 EIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKE-----VIHKLN 235
E +TE + + ++ L + ++ V+ ++ L A+E + K+
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQ 918
Query: 236 LENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNEL-RTEKTLQAR 294
LE + +KE + + + E+ L ++ K E E ++++ ++ ++ L + EK A
Sbjct: 919 LEAK-IKEVTERAEDEEEINAELTAKKRK--LEDECSELKKDIDDLELTLAKVEKEKHAT 975
Query: 295 NNRALEL 301
N+ L
Sbjct: 976 ENKVKNL 982
Score = 32.3 bits (72), Expect = 0.59
Identities = 35/158 (22%), Positives = 68/158 (43%), Gaps = 8/158 (5%)
Query: 144 KLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYEL 203
+L L + +E K + + EE ++ + KE Q+T D + ++
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV 1021
Query: 204 QALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLK---EAVRKLKHQTEVGNVLLK 260
L ++ V +L L+Q K++ L R L+ + ++ TE L
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLN 1081
Query: 261 EEMKSYYELEMAKIRGEL---SVIKNELRTE-KTLQAR 294
E++K E EM+ ++G++ + +L+ + K LQAR
Sbjct: 1082 EKLKK-KEFEMSNLQGKIEDEQALAIQLQKKIKELQAR 1118
>gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
Length = 703
Score = 51.2 bits (121), Expect = 1e-06
Identities = 57/278 (20%), Positives = 118/278 (42%), Gaps = 23/278 (8%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLREN 82
L E + E + S + + + K QE+ K ++ + +E++L E
Sbjct: 261 LLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR-PREESLAE- 318
Query: 83 KRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPAL------LRQDIRKK 136
K+ S+ + D +S N T+E+ + TC +L ++ L Q++ +K
Sbjct: 319 KKYTSQGQGDLDSV-LSQLNFTHTSEDLLQA---EVTCLEGSLESVSATCKQLSQELMEK 374
Query: 137 FMERMSPKLCLNLLNEELEELNMKYRKIEEEFENA----EKELLHYKKEIFTKPLNFQET 192
+ E + N E+++L + + E+ + +A + E+ H +E+ + + T
Sbjct: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
Query: 193 ETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQT 252
+ +S + L+A +KA K + +QL+ L LENR+L E V KL+
Sbjct: 435 KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE-------SLKLENRHLSEMVMKLELGL 487
Query: 253 EVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKT 290
+ +++ Y + K+ E ++ +L K+
Sbjct: 488 HEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKS 525
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 51.2 bits (121), Expect = 1e-06
Identities = 58/255 (22%), Positives = 119/255 (46%), Gaps = 33/255 (12%)
Query: 56 QEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVD--VTTEESFNS 113
Q+E K + + + L +++E+ RE K + E + A + + V + ++
Sbjct: 250 QKEEKLRESEKL--LEALQEEK--RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHA 305
Query: 114 TEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENA-- 171
E S S L Q++ +K+ E + N E+++L + + E+ + +A
Sbjct: 306 VEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALE 365
Query: 172 --EKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKE 229
+ E+ H +E+ + + T+ +S + L+A +KA K + +QL+
Sbjct: 366 GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLE---- 421
Query: 230 VIHKLNLENRNLKEAVRKLK---HQ-----TEVGNV----LLKEEMKSYYELEMAKIRGE 277
L LENR+L E V KL+ H+ + +G++ L +EE++S++ LE ++
Sbjct: 422 ---SLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILE--RLDAH 476
Query: 278 LSVIKNELRTEKTLQ 292
+ +K E +EKT++
Sbjct: 477 IEELKRE--SEKTVR 489
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 50.8 bits (120), Expect = 2e-06
Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 55/338 (16%)
Query: 8 WKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYI 67
WK + T S Q +EE SKG+ + +F E K +
Sbjct: 577 WKSKLETAIASHQQAMEELK----------VSFSKGL----GTETAEFAELKTQIEKMRL 622
Query: 68 FQLNEIEQEQNLRENKRNISKNETDTNSASY-----ESSNVDVTTEESFNSTEDNSTCST 122
+EIE QN ++++R E + A E N + ED
Sbjct: 623 DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 682
Query: 123 -DNLPALLRQDIRKKFMERMSPK----------------------LCLNLLNEELEELNM 159
D L L +I+ K +E + K L L+ L + E
Sbjct: 683 EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS 742
Query: 160 KYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKN 219
+ +K+ ++ E AEK++ H + E + + + +L L+ +LSE + +
Sbjct: 743 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 802
Query: 220 LSEQLQQAKEVIHKLNLE----NRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIR 275
L ++LQ KE + + E R+++E V KL HQ KEE + ++ K+R
Sbjct: 803 LEKELQILKEKFAEASEEAVSVQRSMQETVNKL-HQ--------KEEQFNMLSSDLEKLR 853
Query: 276 GELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTS 313
L+ ++ + R + + + +A E L A M S
Sbjct: 854 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 891
Score = 46.2 bits (108), Expect = 4e-05
Identities = 63/290 (21%), Positives = 128/290 (44%), Gaps = 39/290 (13%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLREN 82
+EE + + + + K +E++ + + QE +K K+ + E+E++ + E
Sbjct: 912 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK----KHEEEKKELERKLSDLEK 967
Query: 83 KRNISKNETDTNSASYESSNVDVTT--EESFNSTEDNSTCSTDNLPALLRQDIRKKFMER 140
K S N+ A YE + + T EE + + + D L ++
Sbjct: 968 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREEN-------- 1019
Query: 141 MSPKLCLNLLNEELEELNMKYRKIE--EEFENAEKELLHYKKEIFTKPLNFQETETDASK 198
+ L +ELEEL + K + + E+A + + KE + ++T+ +K
Sbjct: 1020 -------SGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072
Query: 199 SDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVL 258
EL L K N+KN+ E+L ++KE+ L +EN+ ++E +++ +T
Sbjct: 1073 LQNELDTL------KENNLKNV-EELNKSKEL---LTVENQKMEEFRKEI--ETLKQAAA 1120
Query: 259 LKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQAR----NNRALELLRK 304
K + S + E K+ EL ++E+ + + L+ NN+ LE+ ++
Sbjct: 1121 QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1170
Score = 45.1 bits (105), Expect = 9e-05
Identities = 57/279 (20%), Positives = 115/279 (41%), Gaps = 20/279 (7%)
Query: 45 EEIYNLSS-RKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNV 103
E++ +L + RK E K + KK QL E++ E ++N ++ + + + +
Sbjct: 725 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 784
Query: 104 DVTT-EESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYR 162
+T +E+ + L Q +++KF E + + ++E K
Sbjct: 785 KLTNLQENLSEVSQVKETLEKEL-----QILKEKFAEASEEAVSVQ---RSMQETVNKLH 836
Query: 163 KIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSE 222
+ EE+F +L ++ + F+E + + + L ND++E + S
Sbjct: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 896
Query: 223 QLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLK--EEMKSYYELEMAKIRGELSV 280
QL + + +L L+ R+++E KL E + L K E+M E + +
Sbjct: 897 QLTKMND---ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953
Query: 281 IKNELR-----TEKTLQARNNRALELLRKYYASSMVTSS 314
K EL EK ++ +N+ EL +Y ++ T +
Sbjct: 954 EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
Score = 32.3 bits (72), Expect = 0.59
Identities = 33/156 (21%), Positives = 69/156 (44%), Gaps = 21/156 (13%)
Query: 169 ENAEKEL-LHYKKEIFTKPLNFQETETDASKS----DYELQALRNDL-SEKATNVKNLSE 222
+ A +EL + + K + T+ F E +T K +E++ L+N SE+A + K
Sbjct: 589 QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---- 644
Query: 223 QLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIK 282
+++ + + K+ E N EA+R + E + +EM +L +
Sbjct: 645 EMEALRAKLMKVIKEKENSLEAIRSKLDKAE-----------DQHLVEMEDTLNKLQEAE 693
Query: 283 NELRTEKTLQARNNRALELLRKYYASSMVTSSSILD 318
+++ + LQA+ N +++ + + T +LD
Sbjct: 694 IKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 729
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 50.8 bits (120), Expect = 2e-06
Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 55/338 (16%)
Query: 8 WKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYI 67
WK + T S Q +EE SKG+ + +F E K +
Sbjct: 612 WKSKLETAIASHQQAMEELK----------VSFSKGL----GTETAEFAELKTQIEKMRL 657
Query: 68 FQLNEIEQEQNLRENKRNISKNETDTNSASY-----ESSNVDVTTEESFNSTEDNSTCST 122
+EIE QN ++++R E + A E N + ED
Sbjct: 658 DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 717
Query: 123 -DNLPALLRQDIRKKFMERMSPK----------------------LCLNLLNEELEELNM 159
D L L +I+ K +E + K L L+ L + E
Sbjct: 718 EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS 777
Query: 160 KYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKN 219
+ +K+ ++ E AEK++ H + E + + + +L L+ +LSE + +
Sbjct: 778 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837
Query: 220 LSEQLQQAKEVIHKLNLE----NRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIR 275
L ++LQ KE + + E R+++E V KL HQ KEE + ++ K+R
Sbjct: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVNKL-HQ--------KEEQFNMLSSDLEKLR 888
Query: 276 GELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTS 313
L+ ++ + R + + + +A E L A M S
Sbjct: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 926
Score = 46.2 bits (108), Expect = 4e-05
Identities = 63/290 (21%), Positives = 128/290 (44%), Gaps = 39/290 (13%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLREN 82
+EE + + + + K +E++ + + QE +K K+ + E+E++ + E
Sbjct: 947 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK----KHEEEKKELERKLSDLEK 1002
Query: 83 KRNISKNETDTNSASYESSNVDVTT--EESFNSTEDNSTCSTDNLPALLRQDIRKKFMER 140
K S N+ A YE + + T EE + + + D L ++
Sbjct: 1003 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREEN-------- 1054
Query: 141 MSPKLCLNLLNEELEELNMKYRKIE--EEFENAEKELLHYKKEIFTKPLNFQETETDASK 198
+ L +ELEEL + K + + E+A + + KE + ++T+ +K
Sbjct: 1055 -------SGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107
Query: 199 SDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVL 258
EL L K N+KN+ E+L ++KE+ L +EN+ ++E +++ +T
Sbjct: 1108 LQNELDTL------KENNLKNV-EELNKSKEL---LTVENQKMEEFRKEI--ETLKQAAA 1155
Query: 259 LKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQAR----NNRALELLRK 304
K + S + E K+ EL ++E+ + + L+ NN+ LE+ ++
Sbjct: 1156 QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1205
Score = 45.1 bits (105), Expect = 9e-05
Identities = 57/279 (20%), Positives = 115/279 (41%), Gaps = 20/279 (7%)
Query: 45 EEIYNLSS-RKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNV 103
E++ +L + RK E K + KK QL E++ E ++N ++ + + + +
Sbjct: 760 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 819
Query: 104 DVTT-EESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYR 162
+T +E+ + L Q +++KF E + + ++E K
Sbjct: 820 KLTNLQENLSEVSQVKETLEKEL-----QILKEKFAEASEEAVSVQ---RSMQETVNKLH 871
Query: 163 KIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSE 222
+ EE+F +L ++ + F+E + + + L ND++E + S
Sbjct: 872 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 931
Query: 223 QLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLK--EEMKSYYELEMAKIRGELSV 280
QL + + +L L+ R+++E KL E + L K E+M E + +
Sbjct: 932 QLTKMND---ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988
Query: 281 IKNELR-----TEKTLQARNNRALELLRKYYASSMVTSS 314
K EL EK ++ +N+ EL +Y ++ T +
Sbjct: 989 EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 1027
Score = 32.3 bits (72), Expect = 0.59
Identities = 33/156 (21%), Positives = 69/156 (44%), Gaps = 21/156 (13%)
Query: 169 ENAEKEL-LHYKKEIFTKPLNFQETETDASKS----DYELQALRNDL-SEKATNVKNLSE 222
+ A +EL + + K + T+ F E +T K +E++ L+N SE+A + K
Sbjct: 624 QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---- 679
Query: 223 QLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIK 282
+++ + + K+ E N EA+R + E + +EM +L +
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAE-----------DQHLVEMEDTLNKLQEAE 728
Query: 283 NELRTEKTLQARNNRALELLRKYYASSMVTSSSILD 318
+++ + LQA+ N +++ + + T +LD
Sbjct: 729 IKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 764
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 50.8 bits (120), Expect = 2e-06
Identities = 74/332 (22%), Positives = 151/332 (45%), Gaps = 59/332 (17%)
Query: 1 MDARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLS---SRKFQE 57
++A KH + T Q + ET E +S S T S+ + + + S+ F
Sbjct: 1773 LEATEKHDNQTNVTEE-GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS 1831
Query: 58 ESKFKRKKYIFQLNEIEQE-QNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTED 116
+ Y+ Q++++++ L E K+ KN+ + + E + T S ST+D
Sbjct: 1832 HDEINN--YLQQIDQLKERIAGLEEEKQ---KNKEFSQTLENEKN-----TLLSQISTKD 1881
Query: 117 NSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKI----EEEFENAE 172
+L++++ K +NLLN++++E + K+ EEE ++ E
Sbjct: 1882 GEL-------KMLQEEVTK-----------MNLLNQQIQEELSRVTKLKETAEEEKDDLE 1923
Query: 173 KELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSE-KATNVKNLSEQLQQAKE-- 229
+ L++ E+ N+ + TDA ++N+L E + N+K +L++ K+
Sbjct: 1924 ERLMNQLAELNGSIGNYCQDVTDAQ--------IKNELLESEMKNLKKCVSELEEEKQQL 1975
Query: 230 VIHKLNLENRNLKEAVRKLK-HQTEVGN--------VLLKEEMKSYYELEMAKIR--GEL 278
V K +E+ KE + K++ Q E GN LLKE+ + +L+ IR ++
Sbjct: 1976 VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKI 2035
Query: 279 SVIKNELRTEKTLQARNNRALELLRKYYASSM 310
S ++ ++ + +Q + + LE+ ++ A ++
Sbjct: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Score = 50.1 bits (118), Expect = 3e-06
Identities = 61/237 (25%), Positives = 111/237 (46%), Gaps = 12/237 (5%)
Query: 57 EESKFKRK-KYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTE 115
EES+ K++ + Q I +++ L+ENK + E + E + ES S +
Sbjct: 1473 EESRAKQQIQRKLQAALISRKEALKENKS--LQEELSLARGTIERLTKSLADVESQVSAQ 1530
Query: 116 DNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNL-LNEELEELNMKYRKIEEEFENAEKE 174
+ + ALL+++ R K + M L N L+ E L + + E+ E KE
Sbjct: 1531 NKEKDTVLGRLALLQEE-RDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 175 LLHYKKEIFTKPLNFQETETDASKSDYE--LQALRNDLSEKATNVKNLSEQLQQAKEVIH 232
+ K + +QE + K +YE LQ+ N +S +A ++++ E ++Q K+ ++
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQK-EYEILLQSYEN-VSNEAERIQHVVEAVRQEKQELY 1647
Query: 233 -KLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTE 288
KL N KE ++L+ + E +KE+M+ + + + KI EL + LR E
Sbjct: 1648 GKLRSTEANKKETEKQLQ-EAEQEMEEMKEKMRKFAKSKQQKIL-ELEEENDRLRAE 1702
Score = 47.8 bits (112), Expect = 1e-05
Identities = 56/289 (19%), Positives = 122/289 (42%), Gaps = 22/289 (7%)
Query: 45 EEIYNLSSRKFQEESKFKRKKYIFQLNEIEQ-------EQNLRENKRNISKNETDTNSAS 97
+E+ L S+ + E F + + I++ N E+ Q + E K+N N + + S
Sbjct: 684 DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 98 YESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEEL 157
E + +E TE + L L + R++ ++ S NLL E++ L
Sbjct: 744 EERDQLLSQVKELSMVTELRA--QVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL 801
Query: 158 NMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNV 217
+++ + + + E + EL + L F E T +LQ +++ E A V
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQ-------LQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854
Query: 218 KNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYEL------EM 271
+++S ++++ + + + LE + + + + K E ++E+ + E+ +M
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 272 AKIRGELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILDHF 320
++ E + E++T K +RA E ++ SS + ++
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 963
Score = 44.7 bits (104), Expect = 1e-04
Identities = 66/279 (23%), Positives = 115/279 (41%), Gaps = 25/279 (8%)
Query: 32 SSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQ--EQNLRENKRNISKN 89
S EQ D E L+SR EE K +K I L+ E+ + + E ++ K
Sbjct: 2355 SYEQLETDLQASRE----LTSR-LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 90 ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNL 149
+ + + ++ EE D + + L + +++I++K K +L
Sbjct: 2410 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL 2469
Query: 150 LNEELEELNMKYRKIEEE-----------FENAEKELLHYKKEIFTKPLNFQETETDASK 198
N+ + + Y+++EE + A E K+EI + + ++ +K
Sbjct: 2470 QNDR-DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAK 2528
Query: 199 SDYELQALRNDLSE----KATNVKNLSE-QLQQAKEVIHKLNLENRNLKEAVRKLKHQTE 253
D EL R DL++ K + K L E QLQQ KE+ +K LKE+ +
Sbjct: 2529 LDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRR 2588
Query: 254 VGNVLLKEEMKSYYELEMAKIR-GELSVIKNELRTEKTL 291
N L +E+ E+E K+ +L+ L+ E TL
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTL 2627
Score = 43.1 bits (100), Expect = 3e-04
Identities = 65/291 (22%), Positives = 113/291 (38%), Gaps = 35/291 (12%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQ--EQ 77
Q +L T E + + Q + + M + N +E + KRK Y L E+ Q EQ
Sbjct: 2717 QKLLMVTKENKGLTAQIQS-FGRSMSSLQNSRDHANEELDELKRK-YDASLKELAQLKEQ 2774
Query: 78 NLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKF 137
L +R+ +ET S NSTE+NS + L Q + K
Sbjct: 2775 GLLNRERDALLSETAF----------------SMNSTEENSLSHLEKL----NQQLLSKD 2814
Query: 138 MERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDAS 197
+ + L +++ + ++ E ++ EL ++K K Q + S
Sbjct: 2815 EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK----QRSAAQPS 2870
Query: 198 KSDYELQALR-------NDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKH 250
S E+Q+L+ ND +KNL +Q Q + I +L+ L+E K K
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA 2930
Query: 251 QTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALEL 301
+ L +E + +EL ++ I E+ L A +++ +L
Sbjct: 2931 FQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981
Score = 39.7 bits (91), Expect = 0.004
Identities = 53/255 (20%), Positives = 105/255 (41%), Gaps = 30/255 (11%)
Query: 70 LNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALL 129
L +E+EQ E++ S+ E N A E + ++S ++ D C D L L
Sbjct: 632 LPAVEKEQASTEHQSRTSE-EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK 690
Query: 130 RQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEK-------------ELL 176
Q + + + ++ L+E+ +E++ + IEE +NA+ +LL
Sbjct: 691 SQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLL 750
Query: 177 HYKKEI-FTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLN 235
KE+ L Q + + + ++ E Q R D + + L+EQ IH L+
Sbjct: 751 SQVKELSMVTELRAQVKQLEMNLAEAERQR-RLDYESQTAHDNLLTEQ-------IHSLS 802
Query: 236 LENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELR-------TE 288
+E ++ + L+++ + + E+ L+ E V++ R E
Sbjct: 803 IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
Query: 289 KTLQARNNRALELLR 303
+ QA + + LE+ +
Sbjct: 863 ELSQALSQKELEITK 877
Score = 38.5 bits (88), Expect = 0.008
Identities = 32/174 (18%), Positives = 75/174 (43%), Gaps = 1/174 (0%)
Query: 129 LRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLN 188
+ +IRK+++E++ +EL ++ ++E + +K+ + Y+++I
Sbjct: 1982 VESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT 2041
Query: 189 FQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKL 248
+ E ++S +L+ + +L++ + K +L K ++ E + KL
Sbjct: 2042 VKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
Query: 249 KHQTEVGNVLLKEEMKSYYE-LEMAKIRGELSVIKNELRTEKTLQARNNRALEL 301
K + + +K +MK E LE + E +K + ++ L A + L
Sbjct: 2102 KKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHL 2155
Score = 37.0 bits (84), Expect = 0.024
Identities = 64/313 (20%), Positives = 124/313 (39%), Gaps = 52/313 (16%)
Query: 2 DARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKF 61
+ R +E+ +S + V + E E +QT ++ ++ I K E +F
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
Query: 62 KRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYE---SSNVDVTTEESFNSTEDNS 118
+ + Q+N+ Q++ N+ ++ + E N A + +SN D + +S ++
Sbjct: 1091 QA--LVKQMNQTLQDKT---NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145
Query: 119 TCST--------------DNLPALLRQ--DIRKKFMERMSPKLCL--------NLLNEEL 154
S + + AL ++ ++KK E ++ + + L EEL
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREEL 1205
Query: 155 EELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKA 214
++ Y +++E+F+ KE + ++ + L Q E+ K D E
Sbjct: 1206 KQQKDDYNRLQEQFDEQSKENENIGDQL--RQLQIQVRESIDGKLP------STDQQESC 1257
Query: 215 TNVKNLSEQLQQAKEVIHKLNLENRNL-------KEAVRKLKHQTEVGNVLLKEEMKSYY 267
++ L E L +A E H + NL E L+ T V + K ++K
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI--KAQLK--- 1312
Query: 268 ELEMAKIRGELSV 280
E+E K+ EL V
Sbjct: 1313 EIEAEKVELELKV 1325
Score = 37.0 bits (84), Expect = 0.024
Identities = 57/299 (19%), Positives = 118/299 (39%), Gaps = 27/299 (9%)
Query: 30 ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKN 89
+S +Q D + +E+ + +E+ + K + ++ E+ + E + ++K
Sbjct: 2113 KSQMKQKDEDLERRLEQA---EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169
Query: 90 ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNL 149
+ + N+D T + T+ S+ D + D KK+ + S +
Sbjct: 2170 DKEVQQLQ---ENLDSTVTQLAAFTKSMSSLQDDRDRVI---DEAKKWERKFS-----DA 2218
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDA----SKSDYELQA 205
+ + EE+ +K E+ + +L + +N E D SK+ E+Q
Sbjct: 2219 IQSKEEEIRLK----EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 206 LRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQ-TEVGNVLLK-EEM 263
+ K L QL++ + + H E L+ ++ LK Q T++ N L K +E
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQ 2334
Query: 264 KSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILDHFTG 322
K E IR + + I+N + + L+ + EL + + + I+ +G
Sbjct: 2335 KGNLE---GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSG 2390
Score = 36.6 bits (83), Expect = 0.031
Identities = 33/149 (22%), Positives = 66/149 (44%), Gaps = 7/149 (4%)
Query: 152 EELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLS 211
E L EL K ++++ E+++ + ++ K + +T+ + + ++AL L
Sbjct: 1385 EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 212 EKATN----VKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYY 267
+A +K L +L + K+ ++ E+R ++ RKL+ LKE
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 268 ELEMAKIRGELSVIKNELR-TEKTLQARN 295
EL +A RG + + L E + A+N
Sbjct: 1505 ELSLA--RGTIERLTKSLADVESQVSAQN 1531
Score = 32.7 bits (73), Expect = 0.45
Identities = 71/319 (22%), Positives = 112/319 (35%), Gaps = 90/319 (28%)
Query: 34 EQTTADSSKGMEEIYNLSSRK------FQEESKFKRKKYIFQLNEIEQEQN--------- 78
E T D K ++EI +L S K +QE+ K +K+Y L E N
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV 1636
Query: 79 -------------LRENKRNISKNETDTNSASYESSNVDVTTEESFNST--------EDN 117
LR + N + E A E + + S E+N
Sbjct: 1637 EAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEN 1696
Query: 118 STCSTDNLPALLRQDIRKKFMERMSPKLCLNL-LNEELEELNMKYRKIEEEFEN--AEK- 173
+ PA D K+ ME + L N + EELE + M+Y + ++F++ +EK
Sbjct: 1697 DRLRAEVHPA---GDTAKECMETL---LSSNASMKEELERVKMEYETLSKKFQSLMSEKD 1750
Query: 174 -------ELLHYKKEIFTKPLNFQETET-----------------DASKSDYELQALRND 209
+L H + +K N + TE + + D + R
Sbjct: 1751 SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPT 1810
Query: 210 LSEKATNVK-----------------NLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQT 252
SE + K N +Q+ Q KE I L E + KE + L+++
Sbjct: 1811 CSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEK 1870
Query: 253 EVGNVLLKEEMKSYYELEM 271
N LL + EL+M
Sbjct: 1871 ---NTLLSQISTKDGELKM 1886
Score = 32.0 bits (71), Expect = 0.77
Identities = 61/289 (21%), Positives = 130/289 (44%), Gaps = 34/289 (11%)
Query: 17 FSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQE 76
FS Q L + + + ++++ + +G E + ++SS K +E S+ +K +L + +
Sbjct: 826 FSEQSTLIRSLQSQLQNKES--EVLEGAERVRHISS-KVEELSQALSQK---ELEITKMD 879
Query: 77 QNLRENKRNIS--------KNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPAL 128
Q L E KR++ K++ T + + + EE F+ + T + L L
Sbjct: 880 QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK-EQLNLL 938
Query: 129 LRQDIRKKFMERMSPKLCLNLLNEELEELN----MKYRKIEEEFENAEKELLHYKKEIFT 184
R + KK ++ L + +E++ + +++ EF+ +KE K+++
Sbjct: 939 SRAEEAKKEQVEEDNEVSSGL-KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQA 997
Query: 185 KPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEA 244
+N +E S+ + EL L+++ ++ + ++++ K EN+ E
Sbjct: 998 ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK--------ENKEYSEK 1049
Query: 245 VRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQA 293
K Q E+ + LK+ + S E+E+ IR +L + +L E+ QA
Sbjct: 1050 CVTSKCQ-EI-EIYLKQTI-SEKEVELQHIRKDL---EEKLAAEEQFQA 1092
Score = 31.2 bits (69), Expect = 1.3
Identities = 50/257 (19%), Positives = 104/257 (40%), Gaps = 18/257 (7%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNL 79
+++ E E E TT++ +K EE++ L + ++ + + K + E+ E +L
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAE-SL 1370
Query: 80 RENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCS---TDNLPALLRQDIRKK 136
++ + +D + ED S S ++ AL + I+ +
Sbjct: 1371 QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTK--IQTE 1428
Query: 137 FMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDA 196
+E+ +L+ +L M+ ++ +E + + EL K+ KP E
Sbjct: 1429 IIEQE------DLIKALHTQLEMQAKEHDERIKQLQVELCEMKQ----KPEEIGEESRAK 1478
Query: 197 SKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKL--NLENRNLKEAVRKLKHQTEV 254
+ +LQA E K+L E+L A+ I +L +L + + + + + T +
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL 1538
Query: 255 GNVLLKEEMKSYYELEM 271
G + L +E + EM
Sbjct: 1539 GRLALLQEERDKLITEM 1555
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 50.4 bits (119), Expect = 2e-06
Identities = 71/319 (22%), Positives = 140/319 (43%), Gaps = 55/319 (17%)
Query: 21 DVLEETSEPESSS-----EQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQ 75
DV++++SE + + E+ A + + + R+FQE+ K +K + +I Q
Sbjct: 468 DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527
Query: 76 EQNLREN----------KRNISKNETDTNSASYES-----------SNVDVTTEESFNST 114
E+ +E+ K ++++E E+ S+++ + +E+ N +
Sbjct: 528 EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 115 ED-----NSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYR----KIE 165
+D + + N + + K +E + + L E+L+ L +Y+ K+
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA-LWTEKLQVLKQQYQTEMEKLR 646
Query: 166 EEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQ 225
E+ E ++ LL K+ IF + +T L K T +++LS +L
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKT------------LEKLDVKQTELESLSSELS 694
Query: 226 QAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNEL 285
+ + HKL E LK+ K+K + E +E K++++ ++ I E V +
Sbjct: 695 EVLKARHKLEEELSVLKDQTDKMKQELEA----KMDEQKNHHQQQVDSIIKEHEV--SIQ 748
Query: 286 RTEKTLQARNNRALELLRK 304
RTEK L+ + N+ LELL K
Sbjct: 749 RTEKALKDQINQ-LELLLK 766
Score = 44.3 bits (103), Expect = 1e-04
Identities = 64/304 (21%), Positives = 117/304 (38%), Gaps = 29/304 (9%)
Query: 22 VLEETSEPESSSEQTTADS--SKGMEEIYNLSSRKFQEESKFKRK--KYIFQLNEIEQEQ 77
+L E E + +++ + K E L + +E+K K++ +L++ E++
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQF 999
Query: 78 NLR------ENKRNISK--NETDTNSASYESSNVDVTTEES---FNSTEDNSTCSTDNLP 126
N + N IS + +TN S +V E + E + L
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059
Query: 127 ALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKP 186
+ +++K E K + L E EE+N + ++EE + L ++++ K
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
Query: 187 LNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVR 246
+ D +K L+ L DL++ L EQL + K + + + R + E
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE---DKRKVSELTS 1176
Query: 247 KLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNEL---------RTEKTLQARNNR 297
KLK E L KS LE + E + EL +TE L+A+ N
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNKSLEDKSL--EFKKLSEELAIQLDICCKKTEALLEAKTNE 1234
Query: 298 ALEL 301
+ +
Sbjct: 1235 LINI 1238
Score = 40.4 bits (93), Expect = 0.002
Identities = 48/253 (18%), Positives = 108/253 (42%), Gaps = 22/253 (8%)
Query: 26 TSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRN 85
+ E S+ EQ S+K E SR Q ++ K + +L E + ++ + N
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE--KDEQIN 1482
Query: 86 ISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKL 145
+ K E D + ++ ++ ++S ++++ L +++ + M +
Sbjct: 1483 LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESN----------LETELKSQTARIMELED 1532
Query: 146 CLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQA 205
+ E+E LN + N +K++ H KE+ K +FQE + D ++
Sbjct: 1533 HITQKTIEIESLNEVLKNY-----NQQKDIEH--KELVQKLQHFQEL---GEEKDNRVKE 1582
Query: 206 LRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKS 265
+ V ++ +L+ K+ + +NL ++ +E ++ L+ + E + E+K
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642
Query: 266 YYELEMAKIRGEL 278
E ++A I+ +L
Sbjct: 1643 KAEQKIAAIKKQL 1655
Score = 35.0 bits (79), Expect = 0.091
Identities = 47/224 (20%), Positives = 99/224 (44%), Gaps = 32/224 (14%)
Query: 31 SSSEQTTADSSKGMEEIYNLSSRKFQEES-KFKR--KKYIFQLNEI-EQEQNLRENKRN- 85
+S +TT + + ++ + S++ +++S +FK+ ++ QL+ ++ + L E K N
Sbjct: 1175 TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNE 1234
Query: 86 -ISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPK 144
I+ + + TN+ S+ T + + TC+ L A LRQ
Sbjct: 1235 LINISSSKTNAILSRISHCQHRTTKVKEALLIK-TCTVSELEAQLRQ------------- 1280
Query: 145 LCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETD-------AS 197
L EE LN+ +++ + E E ++ K +I + + + + AS
Sbjct: 1281 -----LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAAS 1335
Query: 198 KSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNL 241
+ + + L+ +LSE V + E+L++ K I L+ + +L
Sbjct: 1336 EKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
Score = 33.1 bits (74), Expect = 0.35
Identities = 67/283 (23%), Positives = 115/283 (40%), Gaps = 56/283 (19%)
Query: 50 LSSRKFQEESKFKR--KKYIFQLNEIEQEQN-----LRENKRNISKNETDT--------N 94
L S+ ++E ++K+ + ++ +LN QE+ L E +++ ++++T N
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 95 SASYESSN-------VDVTTEESFNSTEDNSTCSTDNLPALLRQ---------DIRKKFM 138
A+Y V T EE + + N T L + ++ ++R ++
Sbjct: 1715 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQ 1774
Query: 139 ERM-----------SPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPL 187
ER+ + + L EELEE N KY I ++ EKE K I K
Sbjct: 1775 ERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVA--QHVEKE--GGKNNIQAKQ- 1829
Query: 188 NFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRK 247
N + D K+ E + L +K +K L L + KEV H++ +E K +
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQK---IKELDSCLVRQKEV-HRVEMEELTSKYEKLQ 1885
Query: 248 LKHQTEVGN---VLLKE--EMKSYYELEMAKIRGELSVIKNEL 285
Q + N LL+E E KS L K+ + N+L
Sbjct: 1886 ALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL 1928
Score = 32.0 bits (71), Expect = 0.77
Identities = 36/173 (20%), Positives = 76/173 (43%), Gaps = 22/173 (12%)
Query: 147 LNLLNEELEELNMKYRKIEEEFENAEKE--LLHYKKEIFTKPLNFQETETDASKSDYELQ 204
L L + ++ ++ +E ++ +++ LL +KE + L+ + E + K +
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLH--M 338
Query: 205 ALRNDLSEKATNVKNLSEQLQQAKEVI---------HKLNLENRNLKEAVRKLKHQTEVG 255
A + L + + KNL EQL+Q K ++ L ++ + + ++K T G
Sbjct: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQG 398
Query: 256 NVLLKEEMKS----YYELEMAKIRGELSVIKNELRTEKTLQARNNRALELLRK 304
L +++ KS + ELE A LS + + L+A + ++ + K
Sbjct: 399 EELREQKEKSERAAFEELEKA-----LSTAQKTEEARRKLKAEMDEQIKTIEK 446
Score = 32.0 bits (71), Expect = 0.77
Identities = 38/161 (23%), Positives = 74/161 (45%), Gaps = 22/161 (13%)
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETD------ASKSD--- 200
L + + E N + + E+E E KE ++ +E+ + L + ET+ A K D
Sbjct: 1994 LKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053
Query: 201 -----YE--LQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTE 253
YE L A +++ K +++ E+LQ K+ KL E + V ++ QT+
Sbjct: 2054 RTAKRYEEILDAREEEMTAKVRDLQTQLEELQ--KKYQQKLEQEENPGNDNVTIMELQTQ 2111
Query: 254 VGNVLLKEEMKSYYELEMAKIRGELSVIKNELRT-EKTLQA 293
+ K + S +L+ + R ++ +++ L+ EK + A
Sbjct: 2112 LAQ---KTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149
Score = 28.5 bits (62), Expect = 8.5
Identities = 41/188 (21%), Positives = 79/188 (42%), Gaps = 18/188 (9%)
Query: 129 LRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLN 188
L DI++ E L++ + + + EE+ +++LL + E L
Sbjct: 782 LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL--LT 839
Query: 189 FQETETDASKSDY--ELQALR---NDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKE 243
Q E +A K D EL A + DL ++ + EQ ++ +++ LE+ N KE
Sbjct: 840 KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN-KE 898
Query: 244 AVRKLKHQTEVGNVLL--KEEMKSYYELEMAKIRGE---LSVIKNELRT-----EKTLQA 293
+ + E N++L +E K E+ K+ + + ++ E T EK ++
Sbjct: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEK 958
Query: 294 RNNRALEL 301
+A E+
Sbjct: 959 VKQKAKEM 966
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 50.4 bits (119), Expect = 2e-06
Identities = 65/319 (20%), Positives = 137/319 (42%), Gaps = 36/319 (11%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQE------ 76
L+E+++ + + +T D + +L + +EE + K +K + + + +EQ+
Sbjct: 462 LQESTQTVQALQYSTVDGPLTASK--DLEIKNLKEEIE-KLRKQVTESSHLEQQLEEANA 518
Query: 77 --QNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIR 134
Q L + R I E + E +++ ++ ++ S D R+
Sbjct: 519 VRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKD--AHCQRKLAM 576
Query: 135 KKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETET 194
++FME +NE L EL+ + +K+ + E+E+ +++ + + TE
Sbjct: 577 QEFME----------INERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTE- 625
Query: 195 DASKSDYELQALRNDLSEKATNVKNLSEQLQ----QAKEVIHKLNLENRNLKEAVRKLKH 250
++ EL+ L+ +A+ + L EQ + Q + + L + + V ++H
Sbjct: 626 ---RAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEH 682
Query: 251 QTEVGNVLLKEEMKS-YYELEMAKIRG----ELSVIKNELRTEKTLQARNNRALELLRKY 305
Q E+ + E KS +YE E++K G E+ +K EL + Q N+ + +L+
Sbjct: 683 QQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDK 742
Query: 306 YASSMVTSSSILDHFTGDF 324
+ S S + F +F
Sbjct: 743 LEKTRRESQSEREEFESEF 761
Score = 43.9 bits (102), Expect = 2e-04
Identities = 44/177 (24%), Positives = 83/177 (46%), Gaps = 18/177 (10%)
Query: 129 LRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLN 188
LRQ++R+ ER +L ++ E L K RK+ E+ E+ K+L + + + K ++
Sbjct: 617 LRQELRRT--ERAKKELEVH--TEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQIS 672
Query: 189 FQ--------ETETDASKSDYELQAL--RNDLSEK----ATNVKNLSEQLQQAKEVIHKL 234
+ + E K+D E +++ +LS++ A +KNL ++L ++ L
Sbjct: 673 YSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLAL 732
Query: 235 NLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTL 291
N E LK+ + K + +++ + E K YE E + E + +EL TL
Sbjct: 733 NKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTL 789
>gi|215982794 myosin VA isoform 2 [Homo sapiens]
Length = 1828
Score = 50.1 bits (118), Expect = 3e-06
Identities = 71/333 (21%), Positives = 139/333 (41%), Gaps = 75/333 (22%)
Query: 22 VLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEE-SKFKRKKYIFQLNEIEQEQNLR 80
++++ E + E+ + +K +E N ++Q ++F R + + +++++E L
Sbjct: 1045 IVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRLEERY--DDLKEEMTLM 1102
Query: 81 ENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMER 140
+ TD+ +S ES + F+S +++P+ + KK
Sbjct: 1103 VHVPKPGHKRTDSTHSSNESEYI-------FSS----EIAEMEDIPSRTEEPSEKKVPLD 1151
Query: 141 MSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKP-----------LNF 189
MS L L + + EL + + +++E + E+++L K + +P L
Sbjct: 1152 MSLFL---KLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGAELEYESLKR 1208
Query: 190 QETETDASKSDYELQALRNDLSEKAT----------------NVKNLSEQLQQAKEVIHK 233
QE E++ K EL LR LSEK+ + ++SE+L KE +
Sbjct: 1209 QELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVRKEEVLI 1268
Query: 234 LNLENRNLKEA-------------------VRKLKHQTEVG---------NVLLKEEMKS 265
L + + KEA V+K+K + E+ N LL+ +++S
Sbjct: 1269 LRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRLLESQLQS 1328
Query: 266 Y---YELEMAKIRGELSVIKNELRTEKTLQARN 295
+E E +RGE+ +K E ++ L A+N
Sbjct: 1329 QKRSHENEAEALRGEIQSLKEENNRQQQLLAQN 1361
Score = 33.5 bits (75), Expect = 0.26
Identities = 27/114 (23%), Positives = 52/114 (45%), Gaps = 16/114 (14%)
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRND 209
L +++E N Y+ + E+ N E +ET+ +SD E L +
Sbjct: 932 LQRKVDEQNKDYKCLVEKLTNLE---------------GIYNSETEKLRSDLERLQLSEE 976
Query: 210 LSEKATN-VKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEE 262
++ AT V +L E++ + ++ + + E + ++E + K +TE LKEE
Sbjct: 977 EAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEE 1030
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 50.1 bits (118), Expect = 3e-06
Identities = 67/309 (21%), Positives = 121/309 (39%), Gaps = 26/309 (8%)
Query: 2 DARRKHWKENMFTPFFSAQDVLEETS-----EPESSSEQTTADSSKGMEEIYNLSSRKFQ 56
+ R K ++ + + ++V +E EPE Q + EE+ + +
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 57 EESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTED 116
EE + +R++ Q E E+ Q + +R +++ +E E N+ D
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE--------PEKENAVRD 1237
Query: 117 NSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELL 176
N RQ + +R S + +LL E+ E R E+E ++
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE------RDREQERRRWQQRDR 1291
Query: 177 HYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVK-----NLSEQLQQAKEVI 231
H+ +E + +E + KS E Q LR + EK + EQL Q +E
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE- 1350
Query: 232 HKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTL 291
L + R+ K +L+HQ E G L+EE + + K E ++ + R ++
Sbjct: 1351 QPLRRQERDRKFREEELRHQ-EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 292 QARNNRALE 300
Q R+ + E
Sbjct: 1410 QDRDRKFRE 1418
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/307 (19%), Positives = 121/307 (39%), Gaps = 35/307 (11%)
Query: 2 DARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQE-ESK 60
+ R+ W++ F ++ LE + E+ + K + R+ QE + K
Sbjct: 1280 EQERRRWQQR--DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337
Query: 61 FKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTC 120
F+ ++ + Q E EQ LR +R+ E + ++ EE
Sbjct: 1338 FREEEQLLQERE---EQPLRRQERDRKFREEELR---HQEQGRKFLEEEQ---------- 1381
Query: 121 STDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKK 180
L RQ+ +KF++ C + ++ + K+R+ E++ E++ ++
Sbjct: 1382 ------RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435
Query: 181 EIFTKPLNFQETETDASKSDYELQALRN-DLSEKATNVKNLSEQLQQAKEVIHKLNLENR 239
E + + QE E + + +L+ R+ E+ ++ EQ +E K E +
Sbjct: 1436 E---QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 240 NLK--EAVRKLKHQ----TEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQA 293
L+ E RK + Q E L+EE + + + K E ++ + R ++ Q
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 294 RNNRALE 300
R+ + E
Sbjct: 1553 RDRKFRE 1559
Score = 37.7 bits (86), Expect = 0.014
Identities = 60/259 (23%), Positives = 106/259 (40%), Gaps = 47/259 (18%)
Query: 53 RKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSNVDVTTEESFN 112
RKF+EE + ++ QL E+++ RE ++ + + E + E
Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ----------- 1715
Query: 113 STEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNM----KYRKI-EEE 167
L RQ++ +KF E L +E E+ + +YRKI EEE
Sbjct: 1716 ---------------LRRQELERKFREE-------EQLRQETEQEQLRRQERYRKILEEE 1753
Query: 168 FENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQA 227
E+E +++ + F+E E + + E Q LR+ S++ + EQL+Q
Sbjct: 1754 QLRPEREEQQLRRQ--ERDRKFREEE--QLRQEREEQQLRSQESDRKFREE---EQLRQE 1806
Query: 228 KEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELS-VIKNELR 286
+E +L + R+ K + + Q E L++E Y E E S + EL
Sbjct: 1807 REE-QQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW 1865
Query: 287 TEKTLQARNNRALELLRKY 305
E+ + R R +L ++
Sbjct: 1866 QEEEQKRRQERERKLREEH 1884
Score = 36.2 bits (82), Expect = 0.041
Identities = 63/300 (21%), Positives = 112/300 (37%), Gaps = 61/300 (20%)
Query: 53 RKFQEESKFKRKKYIFQLNE-------IEQEQNLRENKRNISKNETDTNSASYESSNVD- 104
RKF+EE + +++ QL+ +E+EQ LR +R+ E + S E ++
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE 1520
Query: 105 ------------------------------------VTTEESFNSTEDNSTCS---TDNL 125
EE + S D
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 126 PALLRQDIRKKFMERMSPKLCLNLLNEE-----LEELNMKYRKIEEEFENAEKELLHYKK 180
L Q +R++ ER + L +E +E + K+R+ E+ + E++ LH ++
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 181 EIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRN 240
+ F E E + + E Q LR+D K + L LQ+ +E + +R
Sbjct: 1641 ----RDRKFLEEEPQLRRQERE-QQLRHDRDRKFREEEQL---LQEGEEQQLRRQERDRK 1692
Query: 241 LKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE 300
+E ++L+ Q L +E+ ELE K R E + + + + Q R + LE
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELE-RKFREEEQLRQETEQEQLRRQERYRKILE 1751
Score = 35.4 bits (80), Expect = 0.070
Identities = 57/295 (19%), Positives = 114/295 (38%), Gaps = 22/295 (7%)
Query: 24 EETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLR--- 80
EE E + EQ + E ++ + E + +R++ + + ++ +EQ LR
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 81 ENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMER 140
E +R+ K+E + + + + E+ + L++D ++ ER
Sbjct: 430 EEERHEQKHEQERREQRLKREQEE--RRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 141 M----------SPKLCLNLLNEELEELNMKYRKIEEEFENAEKEL-----LHYKKEIFTK 185
+ L E EE + K +EE E ++ L L ++E +
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 186 PLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAV 245
L +E E + E + R + +K E+ QQ + + LE R +E V
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 246 RKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALE 300
+L+ + L +EE + ++ K + + +LR E+ Q R + L+
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ--QERREQRLK 660
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/271 (24%), Positives = 117/271 (43%), Gaps = 41/271 (15%)
Query: 30 ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKN 89
E+ E + +K + + YN K + K K ++ + + E ++E L ++ + S +
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVI-VREFQEE--LVDHLKTFSIS 745
Query: 90 ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNL 149
E+ S+ N++ T T + P ++ RK F ++L
Sbjct: 746 ESPLEGTSHCHINLNETW------TSKKKLFQVEIQPEEKHEEFRKLFE-------LISL 792
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETE---------TDASKSD 200
LN +++ K R++EEE +K L E+ LN E TD K D
Sbjct: 793 LNYTADQIRKKNRELEEEATGYKKCL-----EMTINMLNAFANEDFSCHGDLNTDQLKMD 847
Query: 201 YELQALR---NDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNV 257
+ L+ NDL + V + L + EV+H+ L RN++E KL E
Sbjct: 848 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKL----EKDKK 903
Query: 258 LLKEE---MKSYYELEMAKIRGELSVIKNEL 285
+L+EE +K++ E +M ++ G+L K+EL
Sbjct: 904 MLEEEVLNLKTHMEKDMVEL-GKLQEYKSEL 933
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/271 (24%), Positives = 117/271 (43%), Gaps = 41/271 (15%)
Query: 30 ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKN 89
E+ E + +K + + YN K + K K ++ + + E ++E L ++ + S +
Sbjct: 582 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVI-VREFQEE--LVDHLKTFSIS 638
Query: 90 ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNL 149
E+ S+ N++ T T + P ++ RK F ++L
Sbjct: 639 ESPLEGTSHCHINLNETW------TSKKKLFQVEIQPEEKHEEFRKLFE-------LISL 685
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETE---------TDASKSD 200
LN +++ K R++EEE +K L E+ LN E TD K D
Sbjct: 686 LNYTADQIRKKNRELEEEATGYKKCL-----EMTINMLNAFANEDFSCHGDLNTDQLKMD 740
Query: 201 YELQALR---NDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNV 257
+ L+ NDL + V + L + EV+H+ L RN++E KL E
Sbjct: 741 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKL----EKDKK 796
Query: 258 LLKEE---MKSYYELEMAKIRGELSVIKNEL 285
+L+EE +K++ E +M ++ G+L K+EL
Sbjct: 797 MLEEEVLNLKTHMEKDMVEL-GKLQEYKSEL 826
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 49.7 bits (117), Expect = 4e-06
Identities = 66/271 (24%), Positives = 117/271 (43%), Gaps = 41/271 (15%)
Query: 30 ESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKN 89
E+ E + +K + + YN K + K K ++ + + E ++E L ++ + S +
Sbjct: 689 ENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAEREVI-VREFQEE--LVDHLKTFSIS 745
Query: 90 ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNL 149
E+ S+ N++ T T + P ++ RK F ++L
Sbjct: 746 ESPLEGTSHCHINLNETW------TSKKKLFQVEIQPEEKHEEFRKLFE-------LISL 792
Query: 150 LNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETE---------TDASKSD 200
LN +++ K R++EEE +K L E+ LN E TD K D
Sbjct: 793 LNYTADQIRKKNRELEEEATGYKKCL-----EMTINMLNAFANEDFSCHGDLNTDQLKMD 847
Query: 201 YELQALR---NDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNV 257
+ L+ NDL + V + L + EV+H+ L RN++E KL E
Sbjct: 848 ILFKKLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKL----EKDKK 903
Query: 258 LLKEE---MKSYYELEMAKIRGELSVIKNEL 285
+L+EE +K++ E +M ++ G+L K+EL
Sbjct: 904 MLEEEVLNLKTHMEKDMVEL-GKLQEYKSEL 933
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 49.3 bits (116), Expect = 5e-06
Identities = 45/174 (25%), Positives = 83/174 (47%), Gaps = 27/174 (15%)
Query: 148 NLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETE--TDASKSDYELQA 205
NLL ELEEL + E + AE+EL+ + + + L+ Q T K D +L
Sbjct: 1679 NLLQAELEELRAVVEQTERSRKLAEQELIETSERV--QLLHSQNTSLINQKKKMDADLSQ 1736
Query: 206 LRNDLSEKATNVKN--------------LSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQ 251
L+ ++ E +N ++E+L++ ++ L +N+++ ++ L+H+
Sbjct: 1737 LQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 1796
Query: 252 -TEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQARNNRALELLRK 304
E + LK K +LE A++R ++NEL E Q RN +++ +RK
Sbjct: 1797 LDEAEQIALKGGKKQLQKLE-ARVR----ELENELEAE---QKRNAESVKGMRK 1842
Score = 46.2 bits (108), Expect = 4e-05
Identities = 55/264 (20%), Positives = 107/264 (40%), Gaps = 50/264 (18%)
Query: 70 LNEIEQEQNLRENKRNISK-----NETDTNSASYESSNVDVTTEES-----FNSTEDNST 119
L E+E+ + K ++ +++ E V + E++ + +DN
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899
Query: 120 CSTDNLPALLRQDIR-----KKFMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKE 174
+ + L++ I+ K+ ER+ + +N EL K RK+E+E +++
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA------ELTAKKRKLEDECSELKRD 953
Query: 175 LLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKL 234
+ + E +K + E A N VKNL+E++ E+I KL
Sbjct: 954 I--------------DDLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDEIIAKL 992
Query: 235 NLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRGELSVIKNELRTEKTLQAR 294
E + L+EA HQ + ++ +E+ + K+ ++ ++ L EK ++
Sbjct: 993 TKEKKALQEA-----HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
Query: 295 NNRALELLRKYYASSMVTSSSILD 318
RA RK +T SI+D
Sbjct: 1048 LERA---KRKLEGDLKLTQESIMD 1068
Score = 46.2 bits (108), Expect = 4e-05
Identities = 55/282 (19%), Positives = 118/282 (41%), Gaps = 39/282 (13%)
Query: 21 DVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLR 80
D+L E E E+ ++ E+ + S+ E ++++ K ++ + I++ + L
Sbjct: 1341 DLLREQYEEETEAKA----------ELQRVLSKANSEVAQWRTK---YETDAIQRTEELE 1387
Query: 81 ENKRNISKN----ETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKK 136
E K+ +++ E + + + S+++ T N ED + A D +++
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 137 FMERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDA 196
+++ L E KY + + E E+++KE E+F ++E
Sbjct: 1448 NFDKI------------LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE----- 1490
Query: 197 SKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGN 256
S L+ + + + +L+EQL + + IH+L + L+ +L+ E
Sbjct: 1491 --SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1548
Query: 257 VLLKEEMKSYY--ELEMAKIRGELSVIKNELRTEKTLQARNN 296
L+ E +LE +I+ E+ K + E+ QA+ N
Sbjct: 1549 ASLEHEEGKILRAQLEFNQIKAEIE-RKLAEKDEEMEQAKRN 1589
Score = 41.2 bits (95), Expect = 0.001
Identities = 59/282 (20%), Positives = 125/282 (44%), Gaps = 28/282 (9%)
Query: 53 RKFQEE-SKFKRKKYIFQLN--EIEQEQNLRENK-RNISKNETDTNSASYESSNVDVTTE 108
RK ++E S+ KR +L ++E+E++ ENK +N+++ + + + +
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 109 ESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMKY--RKIEE 166
E+ D+ D + L + ++ +E+ L +L E+ ++++ RK+E
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVK---LEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1057
Query: 167 EFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQ 226
+ + ++ ++ + + Q+ + K D+EL AL + ++ L ++L++
Sbjct: 1058 DLKLTQESIMDLENDK-------QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 227 AKEVIHKLNLE---NRNLKEAVRKLKHQ-----TEVGNVLLKEEMKSYYELEMAKIR-GE 277
+ I +L E R + V KL+ E+ L + + ++EM K R E
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 278 LSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILDH 319
++ +L E TLQ A LRK +A S+ +D+
Sbjct: 1171 FQKMRRDLE-EATLQHEATAA--ALRKKHADSVAELGEQIDN 1209
Score = 39.3 bits (90), Expect = 0.005
Identities = 60/263 (22%), Positives = 109/263 (41%), Gaps = 37/263 (14%)
Query: 22 VLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRE 81
V+E+T +EQ ++S+ ++ +++ ++ ++ K Q E Q R
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 82 NKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERM 141
+ K TD + E E +++ + + + Q I K R+
Sbjct: 1751 AEEKAKKAITDAAMMAEELKK------------EQDTSAHLERMKKNMEQTI-KDLQHRL 1797
Query: 142 --SPKLCLNLLNEELEELNMKYRKIEEEFE-----NAEKELLHYKKEIFTKPLNFQETET 194
+ ++ L ++L++L + R++E E E NAE K E K L +Q TE
Sbjct: 1798 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ-TEE 1856
Query: 195 DASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEV 254
D K+ LQ L + L K VK Q ++A+E N NL + RK++H+ +
Sbjct: 1857 D-RKNLLRLQDLVDKLQLK---VKAYKRQAEEAEE------QANTNLSK-FRKVQHELDE 1905
Query: 255 GNVLLKEEMKSYYELEMAKIRGE 277
EE E ++ K+R +
Sbjct: 1906 A-----EERADIAESQVNKLRAK 1923
Score = 31.6 bits (70), Expect = 1.0
Identities = 50/279 (17%), Positives = 109/279 (39%), Gaps = 31/279 (11%)
Query: 23 LEETSEPESSS----EQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQN 78
LEE E E ++ E+ +D S+ +EEI S + +E ++ E N
Sbjct: 1118 LEEELEAERTARAKVEKLRSDLSRELEEI----SERLEEAGG---------ATSVQIEMN 1164
Query: 79 LRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFM 138
++ + K D A+ + + + DNL + +Q + K
Sbjct: 1165 -KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV-KQKLEK--- 1219
Query: 139 ERMSPKLCLNLLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASK 198
E+ KL L+ + +E++ +E+ E ++ ++ + + + + +K
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK 1279
Query: 199 SDYELQALRNDLSEKATNVKNLS-------EQLQQAKEVIHKLNLENRNLKEAVRKLKHQ 251
E L L EK + L+ +QL+ K + + L A++ +H
Sbjct: 1280 LQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHD 1339
Query: 252 TEVGNVLLKEEMKSYYELE--MAKIRGELSVIKNELRTE 288
++ +EE ++ EL+ ++K E++ + + T+
Sbjct: 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 49.3 bits (116), Expect = 5e-06
Identities = 76/334 (22%), Positives = 145/334 (43%), Gaps = 41/334 (12%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQ---- 75
+ ++E T E + + + ++ I +L K + + + K + + + +E
Sbjct: 52 KQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV 111
Query: 76 -EQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLP------AL 128
+++L E++ I++ E S E + TE+ E+ S C++D + A
Sbjct: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS-CASDQVEKYKLDIAQ 170
Query: 129 LRQDIRKKFMERMSPKLCLN----LLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFT 184
L +++++K E +S K L +L++++E+LN+K + +E+E E+ + + +
Sbjct: 171 LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 230
Query: 185 KPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQ-----AKEVIHKLNLENR 239
+ N ++ + +LQ + K LS L Q +E++ + NL
Sbjct: 231 EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEE 290
Query: 240 NLKEA---VRKLKHQTEVGNVLLK---EEMKSYYE---LEMAKIRGELSVIKNELRTEKT 290
LK+ + KL+ + E L+K EE KS E L K++G+ E EK+
Sbjct: 291 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK------EAELEKS 344
Query: 291 LQARNNRALELLRKYYASSMVTSSSILDHFTGDF 324
A L L KY SMV S L+ T F
Sbjct: 345 SAAHTQATLLLQEKY--DSMVQS---LEDVTAQF 373
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 49.3 bits (116), Expect = 5e-06
Identities = 76/334 (22%), Positives = 145/334 (43%), Gaps = 41/334 (12%)
Query: 20 QDVLEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQ---- 75
+ ++E T E + + + ++ I +L K + + + K + + + +E
Sbjct: 139 KQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV 198
Query: 76 -EQNLRENKRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLP------AL 128
+++L E++ I++ E S E + TE+ E+ S C++D + A
Sbjct: 199 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS-CASDQVEKYKLDIAQ 257
Query: 129 LRQDIRKKFMERMSPKLCLN----LLNEELEELNMKYRKIEEEFENAEKELLHYKKEIFT 184
L +++++K E +S K L +L++++E+LN+K + +E+E E+ + + +
Sbjct: 258 LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 317
Query: 185 KPLNFQETETDASKSDYELQALRNDLSEKATNVKNLSEQLQQ-----AKEVIHKLNLENR 239
+ N ++ + +LQ + K LS L Q +E++ + NL
Sbjct: 318 EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEE 377
Query: 240 NLKEA---VRKLKHQTEVGNVLLK---EEMKSYYE---LEMAKIRGELSVIKNELRTEKT 290
LK+ + KL+ + E L+K EE KS E L K++G+ E EK+
Sbjct: 378 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK------EAELEKS 431
Query: 291 LQARNNRALELLRKYYASSMVTSSSILDHFTGDF 324
A L L KY SMV S L+ T F
Sbjct: 432 SAAHTQATLLLQEKY--DSMVQS---LEDVTAQF 460
Score = 35.4 bits (80), Expect = 0.070
Identities = 67/314 (21%), Positives = 125/314 (39%), Gaps = 50/314 (15%)
Query: 23 LEETSEPESSSEQTTADSSKGMEEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLREN 82
L+ ++P + A K +E + S FQ+ +FK++K E +QNL
Sbjct: 8 LKRFNDPSGCAPSPGAYDVKTLEVLKGPVS--FQKSQRFKQQK--------ESKQNL--- 54
Query: 83 KRNISKNETDTNSASYESSNVDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMS 142
N+ K+ T SA V + ES ++ N D +L ++IR ER +
Sbjct: 55 --NVDKDTTLPASAR------KVKSSESKKESQKN-----DKDLKILEKEIRVLLQERGA 101
Query: 143 PKLCLNLLNEELEELNMKY-----RKIEEEFENA--EKELLHYKK--EIFTKPLNFQETE 193
+ L ELE++ + K NA EK+L+ + E+ + +
Sbjct: 102 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 161
Query: 194 TDASKSDYELQALRNDLSEKATNVKNLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTE 253
+ EL LRN K + E ++ KL + R+L+E+ K+
Sbjct: 162 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEM------KLQVTQRSLEESQGKIAQLEG 215
Query: 254 VGNVLLKEEMKSYYELE-MAKIRGELSVIKNEL--------RTEKTLQARNNRALELLRK 304
+ KE++ E E + + E+S +++ + E+ L+ +N+ L L +
Sbjct: 216 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 275
Query: 305 YYASSMVTSSSILD 318
+ ++ S + D
Sbjct: 276 LEENIVILSKQVED 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.124 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,405,082
Number of Sequences: 37866
Number of extensions: 450031
Number of successful extensions: 5538
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 692
Number of HSP's that attempted gapping in prelim test: 3419
Number of HSP's gapped (non-prelim): 2100
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.