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Search of human proteins with 157384971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157384971 cyclin G associated kinase [Homo sapiens]
(1311 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157384971 cyclin G associated kinase [Homo sapiens] 2672 0.0
gi|7662146 DnaJ (Hsp40) homolog, subfamily C, member 6 [Homo sap... 775 0.0
gi|148277037 AP2 associated kinase 1 [Homo sapiens] 192 2e-48
gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens] 182 1e-45
gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens] 182 1e-45
gi|66529407 tensin [Homo sapiens] 145 2e-34
gi|65288071 tensin 3 [Homo sapiens] 136 2e-31
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 123 1e-27
gi|213972593 TPTE and PTEN homologous inositol lipid phosphatase... 122 2e-27
gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase... 122 2e-27
gi|213972589 TPTE and PTEN homologous inositol lipid phosphatase... 122 2e-27
gi|38787970 tensin like C1 domain containing phosphatase isoform... 120 9e-27
gi|38787957 tensin like C1 domain containing phosphatase isoform... 120 9e-27
gi|38787941 tensin like C1 domain containing phosphatase isoform... 120 9e-27
gi|57165436 serine/threonine kinase 16 [Homo sapiens] 120 9e-27
gi|40549435 transmembrane phosphatase with tensin homology isofo... 119 2e-26
gi|40549433 transmembrane phosphatase with tensin homology isofo... 119 2e-26
gi|109689707 transmembrane phosphatase with tensin homology isof... 119 2e-26
gi|73765544 phosphatase and tensin homolog [Homo sapiens] 116 1e-25
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 113 1e-24
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 113 1e-24
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 110 1e-23
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 102 3e-21
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 101 4e-21
gi|116256471 SNF1-like kinase [Homo sapiens] 98 5e-20
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 96 3e-19
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 92 3e-18
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 92 3e-18
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 92 4e-18
>gi|157384971 cyclin G associated kinase [Homo sapiens]
Length = 1311
Score = 2672 bits (6927), Expect = 0.0
Identities = 1311/1311 (100%), Positives = 1311/1311 (100%)
Query: 1 MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDV 60
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDV
Sbjct: 1 MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDV 60
Query: 61 GSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFL 120
GSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFL
Sbjct: 61 GSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFL 120
Query: 121 LLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL 180
LLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL
Sbjct: 121 LLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLL 180
Query: 181 LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI 240
LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI
Sbjct: 181 LSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI 240
Query: 241 GEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNP 300
GEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNP
Sbjct: 241 GEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNP 300
Query: 301 EERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSG 360
EERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSG
Sbjct: 301 EERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSG 360
Query: 361 GLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVM 420
GLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVM
Sbjct: 361 GLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVM 420
Query: 421 SFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAP 480
SFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAP
Sbjct: 421 SFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAP 480
Query: 481 HLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFS 540
HLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFS
Sbjct: 481 HLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFS 540
Query: 541 MKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCE 600
MKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCE
Sbjct: 541 MKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCE 600
Query: 601 VYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMA 660
VYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMA
Sbjct: 601 VYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMA 660
Query: 661 SMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAP 720
SMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAP
Sbjct: 661 SMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAP 720
Query: 721 PWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS 780
PWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS
Sbjct: 721 PWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDS 780
Query: 781 PPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEG 840
PPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEG
Sbjct: 781 PPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEG 840
Query: 841 QEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQA 900
QEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQA
Sbjct: 841 QEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQA 900
Query: 901 CKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADP 960
CKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADP
Sbjct: 901 CKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADP 960
Query: 961 FGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGE 1020
FGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGE
Sbjct: 961 FGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGE 1020
Query: 1021 PSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNP 1080
PSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNP
Sbjct: 1021 PSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNP 1080
Query: 1081 DPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPK 1140
DPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPK
Sbjct: 1081 DPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPK 1140
Query: 1141 ACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT 1200
ACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT
Sbjct: 1141 ACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT 1200
Query: 1201 IAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAP 1260
IAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAP
Sbjct: 1201 IAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAP 1260
Query: 1261 EQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF 1311
EQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF
Sbjct: 1261 EQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF 1311
>gi|7662146 DnaJ (Hsp40) homolog, subfamily C, member 6 [Homo sapiens]
Length = 913
Score = 775 bits (2000), Expect = 0.0
Identities = 435/981 (44%), Positives = 583/981 (59%), Gaps = 128/981 (13%)
Query: 372 GGFLDILRGGTERLFTNLKD--------TSSKVIQSVANYAKGDLDISYITSRIAVMSFP 423
GG D+++GG RLF+NLKD TSS+VIQSV +Y KGDLD +Y+TSRI VMSFP
Sbjct: 20 GGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFP 79
Query: 424 AEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLH 483
+ V+ +N ++D+R FLDS+H HY VYNLSP++YR ++FH+RVSEC W R+AP LH
Sbjct: 80 LDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLH 139
Query: 484 TLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKR 543
L+ +CRNM+ WL Q+ KNVCVVHC+DGRAAS++ V + FC L+ST A+ + KR
Sbjct: 140 NLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKR 199
Query: 544 CPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYV 603
G+ PSH+RY+ YMCD++A++P PH KP+ ++++ ++P+P F+KQR+GCRP+C+V +
Sbjct: 200 PGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKSITVSPIPFFNKQRNGCRPYCDVLI 259
Query: 604 GDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMK 663
G+ ++ ST ++++M++++++DGK IPL +TVQGDV++ +YH RST+G RLQAK+ + +
Sbjct: 260 GETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSMYHLRSTIGSRLQAKVTNTQ 319
Query: 664 MFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWE 723
+FQ+QFHTGF+P + T +KF K +LDACD+ EKYP LFQV L+VE++P D+ PPWE
Sbjct: 320 IFQLQFHTGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVTLDVELQPHDKVIDLTPPWE 379
Query: 724 NSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPS 783
+ + +NP ILFSS +E QD L+ G+ + P + Y
Sbjct: 380 HYCTKDVNPSILFSSHQEHQDTLALGGQAPIDIPPDNPRHY------------------- 420
Query: 784 SSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEP 843
S F +L WQ++K +E + +E +AL+ ESE SD+ +SS
Sbjct: 421 ---GQSGFFASLCWQDQK-----SEKSFCEEDHAALV--NQESEQSDDELLTLSSPHGNA 470
Query: 844 RADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKA 903
D +P G+ +Q + PA P P + VDLLGL + PP A
Sbjct: 471 NGD-KPHGVKKPSKKQ------QEPAAPPPP----EDVDLLGLEGSAMSNSFSPP---AA 516
Query: 904 PSSNTDLLSCLLG-----PPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRG------ 952
P +N++LLS L G P A Q ED+ P+ P S QSTPR
Sbjct: 517 PPTNSELLSDLFGGGGAAGPTQAGQSGVEDVF--------HPSGPASTQSTPRRSATSTS 568
Query: 953 -------GPPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPP 1005
G A DPFG SG DL G FLN+ S + P F +P P
Sbjct: 569 ASPTLRVGEGATFDPFGAPSKPSGQ--------DLLGSFLNTSSASSDP-FLQPTRSPSP 619
Query: 1006 SCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQP 1065
+ A S A + PD+ GGW + + A P S G P
Sbjct: 620 TVHA------------SSTPAVNIQPDVSGGWDWHAKPGGFGMGSKSAATSPTGSSHGTP 667
Query: 1066 APCGSQASWTKSQNPDPFADLGDLSSGL--------QGSPAGFPPGGFIPKTATTPKGSS 1117
+K Q DPFADLG L S G GFPP K + P G
Sbjct: 668 ------THQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMG-G 720
Query: 1118 SWQTSRPPAQGASW---PPQAKPPPK---ACTQPRPNYASNFSVI-GAREERGVRAPSFA 1170
WQ QG ++ PQ KP P + Q RPNY +FS + G + ERG + +
Sbjct: 721 GWQ------QGGAYNWQQPQPKPQPSMPHSSPQNRPNYNVSFSAMPGGQNERGKGSSNLE 774
Query: 1171 QKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERN 1230
K K + DFEDLLS QGF++ DKKGP+TIAEMRK+++AK+ DP KLK+L+WIEGKERN
Sbjct: 775 GKQKAA--DFEDLLSGQGFNAHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERN 832
Query: 1231 IRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKM 1290
IRALLST+HTVLW GE++W PVGMADLV PEQVKK YR+AVL VHPDKA GQPYEQ+AKM
Sbjct: 833 IRALLSTMHTVLWAGETKWKPVGMADLVTPEQVKKVYRKAVLVVHPDKATGQPYEQYAKM 892
Query: 1291 IFMELNDAWSEFENQGSRPLF 1311
IFMELNDAWSEFENQG +PL+
Sbjct: 893 IFMELNDAWSEFENQGQKPLY 913
>gi|148277037 AP2 associated kinase 1 [Homo sapiens]
Length = 961
Score = 192 bits (488), Expect = 2e-48
Identities = 117/299 (39%), Positives = 168/299 (56%), Gaps = 10/299 (3%)
Query: 13 GPGSLGGASGRDQ--SDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKR 70
G GS GG S ++G+ +G ++ V VLAEGGFA V+ + +G + ALKR
Sbjct: 17 GSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKR 75
Query: 71 LLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130
+ N E + +E+ M+ LSGH NIV + ++ D E L+L + C+G
Sbjct: 76 MFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW--EVLILMDFCRGGQ 133
Query: 131 VEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLC 190
V L + + + VL+IF TC AV +H+ K PIIHRDLKVEN+LL ++G LC
Sbjct: 134 VVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLC 193
Query: 191 DFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALG 250
DFGSAT P + VE+EI + TT YR PE+++LYS I K DIWALG
Sbjct: 194 DFGSATNKFQNP----QTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALG 249
Query: 251 CILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 309
C+LY LC+ PF + +++ I +G ++IP + H LIR ML+ +P++R I +V
Sbjct: 250 CLLYKLCYFTLPFGE-SQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 307
>gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
Length = 1161
Score = 182 bits (463), Expect = 1e-45
Identities = 122/301 (40%), Positives = 163/301 (54%), Gaps = 15/301 (4%)
Query: 12 AGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 71
AG G G S + +G ++ + LAEGGF+ V+ + G G ALKR+
Sbjct: 23 AGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRM 81
Query: 72 LSNEEEKNRAIIQEVCFMKKLSGHPNIVQF--CSAASIGKEESDTGQAEFLLLTELCK-G 128
N +E+ MK+LSGH NIV + C+ SI E L+L E C+ G
Sbjct: 82 YVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVW-----EVLILMEYCRAG 136
Query: 129 QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIK 188
Q+V + K G + VL+IF TC AV +H+ K PIIHRDLKVEN+LL++ G
Sbjct: 137 QVVNQMNKKLQTG-FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV 195
Query: 189 LCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWA 248
LCDFGSAT P +VEEEI + TT YR PE+I+LY PI K DIWA
Sbjct: 196 LCDFGSATNKFLNP----QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWA 251
Query: 249 LGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAE 308
LGC+LY LCF PF + +++ I +G ++IP + H LIR ML+ +PE R I +
Sbjct: 252 LGCLLYKLCFFTLPFGE-SQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQ 310
Query: 309 V 309
V
Sbjct: 311 V 311
>gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
Length = 662
Score = 182 bits (463), Expect = 1e-45
Identities = 122/301 (40%), Positives = 163/301 (54%), Gaps = 15/301 (4%)
Query: 12 AGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL 71
AG G G S + +G ++ + LAEGGF+ V+ + G G ALKR+
Sbjct: 23 AGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRM 81
Query: 72 LSNEEEKNRAIIQEVCFMKKLSGHPNIVQF--CSAASIGKEESDTGQAEFLLLTELCK-G 128
N +E+ MK+LSGH NIV + C+ SI E L+L E C+ G
Sbjct: 82 YVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVW-----EVLILMEYCRAG 136
Query: 129 QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIK 188
Q+V + K G + VL+IF TC AV +H+ K PIIHRDLKVEN+LL++ G
Sbjct: 137 QVVNQMNKKLQTG-FTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV 195
Query: 189 LCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWA 248
LCDFGSAT P +VEEEI + TT YR PE+I+LY PI K DIWA
Sbjct: 196 LCDFGSATNKFLNP----QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWA 251
Query: 249 LGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAE 308
LGC+LY LCF PF + +++ I +G ++IP + H LIR ML+ +PE R I +
Sbjct: 252 LGCLLYKLCFFTLPFGE-SQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQ 310
Query: 309 V 309
V
Sbjct: 311 V 311
>gi|66529407 tensin [Homo sapiens]
Length = 1735
Score = 145 bits (367), Expect = 2e-34
Identities = 169/694 (24%), Positives = 278/694 (40%), Gaps = 61/694 (8%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFH 466
+LD+ Y+T RI +SFP+ E ++N+ +V L SKH G+Y ++NLS R ++ H
Sbjct: 12 ELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLH 71
Query: 467 NRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFC 526
+V E GW P L + +IC+ M WL D NV V+H R V + +++ +
Sbjct: 72 AKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYS 131
Query: 527 RLFSTAEAAVYMFSMKR-----CPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVV 581
+ ++A+ A+ F+MKR P PS +RY+ Y +++ I ++KP+ + V+
Sbjct: 132 NISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGS-IKMNNKPLFLHHVI 190
Query: 582 MTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVL 641
M +P F + + GCRPF +Y + V TS Y+ D + + P G+ ++GD+L
Sbjct: 191 MHGIPNF-ESKGGCRPFLRIYQAMQPV-YTSGIYNIPGDSQTSVCITIEP-GLLLKGDIL 247
Query: 642 IVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLF 701
+ YH + A +F++QFHT + + V F K DLD +++P+
Sbjct: 248 LKCYHKKF-------RSPARDVIFRVQFHTCAI--HDLGVVFGKEDLDDAFKDDRFPEYG 298
Query: 702 QVNLEVEVEP---RDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQP 758
+V P + E P + +P I R + D S +
Sbjct: 299 KVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLI----RWDSYDNFSGHRDDGMEEVV 354
Query: 759 GSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESA 818
G T G+ + + DS + + +A+R TL T + ++ S S ++
Sbjct: 355 GHTQGPLDGSLYAKVKKKDSLHGSTGAVNATR--PTLSATPNHVEHTLSVSSDSGNSTAS 412
Query: 819 LMEDRDESEVSDEGGSPISSEGQEPR-ADPEPPGLAAGLVQQDLVFEVETPAVLP---EP 874
D+ + V + + QE R D G +Q ++ + P
Sbjct: 413 TKTDKTDEPVPGASSATAALSPQEKRELDRLLSGFGLEREKQGAMYHTQHLRSRPAGGSA 472
Query: 875 VPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDP 934
VP G ++ V G A TD+L L + S G L S D
Sbjct: 473 VP-SSGRHVVPAQVHVNGG-------ALASERETDILDDELPNQDGHSAGSMGTLSSLD- 523
Query: 935 LLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPP 994
V +T GG P A P ++G + P + G +S +
Sbjct: 524 ----------GVTNTSEGGYPEALSPL-----TNGLDKSYPMEPMVNGGGYPYESASRAG 568
Query: 995 SFPSAHSAP-PPSCSAD-----FLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASAV 1048
+ H+AP PS SA + G P P +T S D G + + + + A
Sbjct: 569 PAHAGHTAPMRPSYSAQEGLAGYQREGPHPAWPQPVTTSHYAHDPSGMFRSQSFSEAEPQ 628
Query: 1049 APTPATEGPLFSPGGQPAPCGSQASWTKSQNPDP 1082
P G Q Q + Q P P
Sbjct: 629 LPPAPVRGGSSREAVQRGLNSWQQQQQQQQQPRP 662
>gi|65288071 tensin 3 [Homo sapiens]
Length = 1445
Score = 136 bits (342), Expect = 2e-31
Identities = 88/309 (28%), Positives = 157/309 (50%), Gaps = 18/309 (5%)
Query: 408 LDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHN 467
LD++YIT RI +SFPA E + +N+++V L SKH +Y V NLS + Y ++ +
Sbjct: 7 LDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYDLTKLNP 66
Query: 468 RVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCR 527
++ + GW AP L + IC+ +WL + ++V V+HC G+ V + S++ F
Sbjct: 67 KIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSYMHFTN 126
Query: 528 LFSTAEAAVYMFSMK-----RCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVM 582
+ ++A+ A+ F+MK + + PS KRY++++ +++ + ++ P+ + V++
Sbjct: 127 VSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGS-VKMNASPLFLHFVIL 185
Query: 583 TPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLI 642
P F CRPF ++Y + V TS Y+ + + P + ++GDV++
Sbjct: 186 HGTPNFD-TGGVCRPFLKLYQAMQPV-YTSGIYNVGPENPSRICIVIEPAQL-LKGDVMV 242
Query: 643 VIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQ 702
YH + R +F++QFHTG V + F K DLD +++PD +
Sbjct: 243 KCYHKKYRSATR-------DVIFRLQFHTGAV--QGYGLVFGKEDLDNASKDDRFPDYGK 293
Query: 703 VNLEVEVEP 711
V L P
Sbjct: 294 VELVFSATP 302
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 123 bits (309), Expect = 1e-27
Identities = 90/279 (32%), Positives = 141/279 (50%), Gaps = 45/279 (16%)
Query: 46 LAEGGFAFVYEAQDVGSGREYALK-----RLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQ 100
+ EG F + GR+Y +K R+ S E E++R + + MK HPNIVQ
Sbjct: 10 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK----HPNIVQ 65
Query: 101 FCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMES-RGPL-SCDTVLKIFYQTCRA 158
+ ES ++ + C+G + K++ + +G L D +L F Q C A
Sbjct: 66 Y--------RESFEENGSLYIVMDYCEGG--DLFKRINAQKGVLFQEDQILDWFVQICLA 115
Query: 159 VQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI 218
++H+H +K I+HRD+K +N+ L+ GT++L DFG A ++ + VE
Sbjct: 116 LKHVHDRK--ILHRDIKSQNIFLTKDGTVQLGDFGIARVLN------------STVELAR 161
Query: 219 TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAK----LRIVNG 274
T TP Y +PEI + N P K DIWALGC+LY LC +H FE G+ L+I++G
Sbjct: 162 TCIGTPYYLSPEICE---NKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG 218
Query: 275 KYSIPPHDTQYTV-FHSLIRAMLQVNPEERLSIAEVVHQ 312
S PP Y+ SL+ + + NP +R S+ ++ +
Sbjct: 219 --SFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEK 255
>gi|213972593 TPTE and PTEN homologous inositol lipid phosphatase
isoform delta [Homo sapiens]
Length = 411
Score = 122 bits (306), Expect = 2e-27
Identities = 64/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++Y+T RI MSFP+ G +S +N IE+V FLD KH HY VYNL S R Y P F
Sbjct: 107 DLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 166
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
HNRVS P LH + + ++ W+ QD +N+ +HC G+ + VC+ L
Sbjct: 167 HNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIA 226
Query: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
+F TAE ++Y F +R G+ PS RY+ Y +
Sbjct: 227 SEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQV 271
>gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase
isoform gamma [Homo sapiens]
Length = 522
Score = 122 bits (306), Expect = 2e-27
Identities = 64/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++Y+T RI MSFP+ G +S +N IE+V FLD KH HY VYNL S R Y P F
Sbjct: 218 DLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 277
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
HNRVS P LH + + ++ W+ QD +N+ +HC G+ + VC+ L
Sbjct: 278 HNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIA 337
Query: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
+F TAE ++Y F +R G+ PS RY+ Y +
Sbjct: 338 SEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQV 382
>gi|213972589 TPTE and PTEN homologous inositol lipid phosphatase
isoform alpha [Homo sapiens]
Length = 445
Score = 122 bits (306), Expect = 2e-27
Identities = 64/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++Y+T RI MSFP+ G +S +N IE+V FLD KH HY VYNL S R Y P F
Sbjct: 141 DLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 200
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
HNRVS P LH + + ++ W+ QD +N+ +HC G+ + VC+ L
Sbjct: 201 HNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIA 260
Query: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
+F TAE ++Y F +R G+ PS RY+ Y +
Sbjct: 261 SEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQV 305
>gi|38787970 tensin like C1 domain containing phosphatase isoform 3
[Homo sapiens]
Length = 1285
Score = 120 bits (301), Expect = 9e-27
Identities = 84/305 (27%), Positives = 156/305 (51%), Gaps = 20/305 (6%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFH 466
DLD++Y+T RI +FPA E + ++ ++ L SKH Y ++NLS + + +R +
Sbjct: 6 DLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLN 65
Query: 467 NRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFC 526
+V + GW AP L L +IC+ M WL D ++V V++C + V V +++ +
Sbjct: 66 PKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYS 125
Query: 527 RLFSTAEAAVYMFSMK-----RCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVV 581
++ + A+ A+ +M+ + + PS +RYI Y +++ I +S P+ + V+
Sbjct: 126 KISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGS-IRMNSSPLFLHYVL 184
Query: 582 MTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVL 641
+ +P F + +G +PF ++Y + V TS Y + ++ P + ++GDV+
Sbjct: 185 IPMLPAF-EPGTGFQPFLKIYQSMQLV-YTSGVYHIAGPGPQQLCISLEP-ALLLKGDVM 241
Query: 642 IVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLF 701
+ YH GGR + +F++QFHT + + + F K LD E++P F
Sbjct: 242 VTCYHK----GGRGTDRTL---VFRVQFHTCTI--HGPQLTFPKDQLDEAWTDERFP--F 290
Query: 702 QVNLE 706
Q ++E
Sbjct: 291 QASVE 295
Score = 35.0 bits (79), Expect = 0.47
Identities = 63/237 (26%), Positives = 88/237 (37%), Gaps = 33/237 (13%)
Query: 757 QPGSTAQYDAGAGSPEAEPTDSDSPPSSSADA-SRFLHTLDWQEEKEAETGAENASSKES 815
+P S + +G + P D+ SS S LHT + KE+ + S +
Sbjct: 752 EPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSA 811
Query: 816 ESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPV 875
+ + + + G+ + E + PEP LA V P P
Sbjct: 812 PTQRLSPGEALPPVSQAGTGKAPE-LPSGSGPEP--LAPSPVSPTF------PPSSPSDW 862
Query: 876 PQEDGVDLLGLHSEVGAGPAVP-----PQACKAPSSNTDLLSCLLGPPEAASQGPPEDLL 930
PQE G HS+ GA P P P AP GPP++ P +
Sbjct: 863 PQERSP---GGHSD-GASPRSPVPTTLPGLRHAPWQGPR------GPPDSPDGSPLTPVP 912
Query: 931 SEDPLLLASPAPPLSVQSTPRGGPPAAA--DPFG---PLLPSSGNNSQPCSNPDLFG 982
S+ P L+ASP PP QS+P P AA D G P LP + P P +G
Sbjct: 913 SQMPWLVASPEPP---QSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWG 966
Score = 32.7 bits (73), Expect = 2.3
Identities = 62/263 (23%), Positives = 85/263 (32%), Gaps = 50/263 (19%)
Query: 926 PEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPC-----SNPDL 980
P L S PL A P+S + P G P +S S P S+P
Sbjct: 736 PGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQ 795
Query: 981 FGEFLNSDSVTVPPSFPSAHSAP----PPSCSADFLHLGDLPGE--PSKMTASSSNPDLL 1034
E P S P+ +P PP A +LP P + S +P
Sbjct: 796 GKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPSPVSPTFP 855
Query: 1035 GGWAA-WTET--------AASAVAPTPAT------------EGPLFSPGGQP-APCGSQA 1072
+ W + AS +P P T GP SP G P P SQ
Sbjct: 856 PSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQM 915
Query: 1073 SWTKSQ------NPDPFADLGDL--SSGLQGSPA---------GFPPGGFIPKTATTPKG 1115
W + +P P L ++GL P G PG + P+ A++P
Sbjct: 916 PWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPAR 975
Query: 1116 SSSWQTSRPPAQGASWPPQAKPP 1138
S + P + P +PP
Sbjct: 976 GISHHVTFAPLLSDNVPQTPEPP 998
Score = 31.2 bits (69), Expect = 6.8
Identities = 26/98 (26%), Positives = 38/98 (38%), Gaps = 6/98 (6%)
Query: 1104 GFIPKTATTPKGSSSWQTSRPPAQGASWP-PQAKPPPKACTQPRPNYASNFSVIGAREER 1162
G + T GS Q RPP Q P P+ PPP ++S + A E
Sbjct: 345 GSLTHTRGPLDGSPYAQVQRPPRQTPPAPSPEPPPPPMLSVSSDSGHSSTLTTEPAAESP 404
Query: 1163 GVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT 1200
G P+ A++ + + LL G +S G +T
Sbjct: 405 GRPPPTAAER-----QELDRLLGGCGVASGGRGAGRET 437
>gi|38787957 tensin like C1 domain containing phosphatase isoform 2
[Homo sapiens]
Length = 1409
Score = 120 bits (301), Expect = 9e-27
Identities = 84/305 (27%), Positives = 156/305 (51%), Gaps = 20/305 (6%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFH 466
DLD++Y+T RI +FPA E + ++ ++ L SKH Y ++NLS + + +R +
Sbjct: 130 DLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLN 189
Query: 467 NRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFC 526
+V + GW AP L L +IC+ M WL D ++V V++C + V V +++ +
Sbjct: 190 PKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYS 249
Query: 527 RLFSTAEAAVYMFSMK-----RCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVV 581
++ + A+ A+ +M+ + + PS +RYI Y +++ I +S P+ + V+
Sbjct: 250 KISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGS-IRMNSSPLFLHYVL 308
Query: 582 MTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVL 641
+ +P F + +G +PF ++Y + V TS Y + ++ P + ++GDV+
Sbjct: 309 IPMLPAF-EPGTGFQPFLKIYQSMQLV-YTSGVYHIAGPGPQQLCISLEP-ALLLKGDVM 365
Query: 642 IVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLF 701
+ YH GGR + +F++QFHT + + + F K LD E++P F
Sbjct: 366 VTCYHK----GGRGTDRTL---VFRVQFHTCTI--HGPQLTFPKDQLDEAWTDERFP--F 414
Query: 702 QVNLE 706
Q ++E
Sbjct: 415 QASVE 419
Score = 35.0 bits (79), Expect = 0.47
Identities = 63/237 (26%), Positives = 88/237 (37%), Gaps = 33/237 (13%)
Query: 757 QPGSTAQYDAGAGSPEAEPTDSDSPPSSSADA-SRFLHTLDWQEEKEAETGAENASSKES 815
+P S + +G + P D+ SS S LHT + KE+ + S +
Sbjct: 876 EPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSA 935
Query: 816 ESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPV 875
+ + + + G+ + E + PEP LA V P P
Sbjct: 936 PTQRLSPGEALPPVSQAGTGKAPE-LPSGSGPEP--LAPSPVSPTF------PPSSPSDW 986
Query: 876 PQEDGVDLLGLHSEVGAGPAVP-----PQACKAPSSNTDLLSCLLGPPEAASQGPPEDLL 930
PQE G HS+ GA P P P AP GPP++ P +
Sbjct: 987 PQERSP---GGHSD-GASPRSPVPTTLPGLRHAPWQGPR------GPPDSPDGSPLTPVP 1036
Query: 931 SEDPLLLASPAPPLSVQSTPRGGPPAAA--DPFG---PLLPSSGNNSQPCSNPDLFG 982
S+ P L+ASP PP QS+P P AA D G P LP + P P +G
Sbjct: 1037 SQMPWLVASPEPP---QSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWG 1090
Score = 32.7 bits (73), Expect = 2.3
Identities = 62/263 (23%), Positives = 85/263 (32%), Gaps = 50/263 (19%)
Query: 926 PEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPC-----SNPDL 980
P L S PL A P+S + P G P +S S P S+P
Sbjct: 860 PGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQ 919
Query: 981 FGEFLNSDSVTVPPSFPSAHSAP----PPSCSADFLHLGDLPGE--PSKMTASSSNPDLL 1034
E P S P+ +P PP A +LP P + S +P
Sbjct: 920 GKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPSPVSPTFP 979
Query: 1035 GGWAA-WTET--------AASAVAPTPAT------------EGPLFSPGGQP-APCGSQA 1072
+ W + AS +P P T GP SP G P P SQ
Sbjct: 980 PSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQM 1039
Query: 1073 SWTKSQ------NPDPFADLGDL--SSGLQGSPA---------GFPPGGFIPKTATTPKG 1115
W + +P P L ++GL P G PG + P+ A++P
Sbjct: 1040 PWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPAR 1099
Query: 1116 SSSWQTSRPPAQGASWPPQAKPP 1138
S + P + P +PP
Sbjct: 1100 GISHHVTFAPLLSDNVPQTPEPP 1122
Score = 31.2 bits (69), Expect = 6.8
Identities = 26/98 (26%), Positives = 38/98 (38%), Gaps = 6/98 (6%)
Query: 1104 GFIPKTATTPKGSSSWQTSRPPAQGASWP-PQAKPPPKACTQPRPNYASNFSVIGAREER 1162
G + T GS Q RPP Q P P+ PPP ++S + A E
Sbjct: 469 GSLTHTRGPLDGSPYAQVQRPPRQTPPAPSPEPPPPPMLSVSSDSGHSSTLTTEPAAESP 528
Query: 1163 GVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT 1200
G P+ A++ + + LL G +S G +T
Sbjct: 529 GRPPPTAAER-----QELDRLLGGCGVASGGRGAGRET 561
>gi|38787941 tensin like C1 domain containing phosphatase isoform 1
[Homo sapiens]
Length = 1419
Score = 120 bits (301), Expect = 9e-27
Identities = 84/305 (27%), Positives = 156/305 (51%), Gaps = 20/305 (6%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFH 466
DLD++Y+T RI +FPA E + ++ ++ L SKH Y ++NLS + + +R +
Sbjct: 140 DLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLN 199
Query: 467 NRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFC 526
+V + GW AP L L +IC+ M WL D ++V V++C + V V +++ +
Sbjct: 200 PKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYS 259
Query: 527 RLFSTAEAAVYMFSMK-----RCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVV 581
++ + A+ A+ +M+ + + PS +RYI Y +++ I +S P+ + V+
Sbjct: 260 KISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGS-IRMNSSPLFLHYVL 318
Query: 582 MTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVL 641
+ +P F + +G +PF ++Y + V TS Y + ++ P + ++GDV+
Sbjct: 319 IPMLPAF-EPGTGFQPFLKIYQSMQLV-YTSGVYHIAGPGPQQLCISLEP-ALLLKGDVM 375
Query: 642 IVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLF 701
+ YH GGR + +F++QFHT + + + F K LD E++P F
Sbjct: 376 VTCYHK----GGRGTDRTL---VFRVQFHTCTI--HGPQLTFPKDQLDEAWTDERFP--F 424
Query: 702 QVNLE 706
Q ++E
Sbjct: 425 QASVE 429
Score = 35.0 bits (79), Expect = 0.47
Identities = 63/237 (26%), Positives = 88/237 (37%), Gaps = 33/237 (13%)
Query: 757 QPGSTAQYDAGAGSPEAEPTDSDSPPSSSADA-SRFLHTLDWQEEKEAETGAENASSKES 815
+P S + +G + P D+ SS S LHT + KE+ + S +
Sbjct: 886 EPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSA 945
Query: 816 ESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPV 875
+ + + + G+ + E + PEP LA V P P
Sbjct: 946 PTQRLSPGEALPPVSQAGTGKAPE-LPSGSGPEP--LAPSPVSPTF------PPSSPSDW 996
Query: 876 PQEDGVDLLGLHSEVGAGPAVP-----PQACKAPSSNTDLLSCLLGPPEAASQGPPEDLL 930
PQE G HS+ GA P P P AP GPP++ P +
Sbjct: 997 PQERSP---GGHSD-GASPRSPVPTTLPGLRHAPWQGPR------GPPDSPDGSPLTPVP 1046
Query: 931 SEDPLLLASPAPPLSVQSTPRGGPPAAA--DPFG---PLLPSSGNNSQPCSNPDLFG 982
S+ P L+ASP PP QS+P P AA D G P LP + P P +G
Sbjct: 1047 SQMPWLVASPEPP---QSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWG 1100
Score = 32.7 bits (73), Expect = 2.3
Identities = 62/263 (23%), Positives = 85/263 (32%), Gaps = 50/263 (19%)
Query: 926 PEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPC-----SNPDL 980
P L S PL A P+S + P G P +S S P S+P
Sbjct: 870 PGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQ 929
Query: 981 FGEFLNSDSVTVPPSFPSAHSAP----PPSCSADFLHLGDLPGE--PSKMTASSSNPDLL 1034
E P S P+ +P PP A +LP P + S +P
Sbjct: 930 GKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPSPVSPTFP 989
Query: 1035 GGWAA-WTET--------AASAVAPTPAT------------EGPLFSPGGQP-APCGSQA 1072
+ W + AS +P P T GP SP G P P SQ
Sbjct: 990 PSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQM 1049
Query: 1073 SWTKSQ------NPDPFADLGDL--SSGLQGSPA---------GFPPGGFIPKTATTPKG 1115
W + +P P L ++GL P G PG + P+ A++P
Sbjct: 1050 PWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPAR 1109
Query: 1116 SSSWQTSRPPAQGASWPPQAKPP 1138
S + P + P +PP
Sbjct: 1110 GISHHVTFAPLLSDNVPQTPEPP 1132
Score = 31.2 bits (69), Expect = 6.8
Identities = 26/98 (26%), Positives = 38/98 (38%), Gaps = 6/98 (6%)
Query: 1104 GFIPKTATTPKGSSSWQTSRPPAQGASWP-PQAKPPPKACTQPRPNYASNFSVIGAREER 1162
G + T GS Q RPP Q P P+ PPP ++S + A E
Sbjct: 479 GSLTHTRGPLDGSPYAQVQRPPRQTPPAPSPEPPPPPMLSVSSDSGHSSTLTTEPAAESP 538
Query: 1163 GVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKT 1200
G P+ A++ + + LL G +S G +T
Sbjct: 539 GRPPPTAAER-----QELDRLLGGCGVASGGRGAGRET 571
>gi|57165436 serine/threonine kinase 16 [Homo sapiens]
Length = 305
Score = 120 bits (301), Expect = 9e-27
Identities = 89/296 (30%), Positives = 151/296 (51%), Gaps = 25/296 (8%)
Query: 32 TVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKK 91
TV + R + L EGGF++V + + G YALKR+L +E++ +R Q M +
Sbjct: 12 TVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQ-DREEAQREADMHR 70
Query: 92 LSGHPNI---VQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP-LSCDT 147
L HPNI V +C K E+ +LLL +G L +++++ +G L+ D
Sbjct: 71 LFNHPNILRLVAYCLRERGAKHEA------WLLLPFFKRGTLWNEIERLKDKGNFLTEDQ 124
Query: 148 VLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWS 207
+L + CR ++ +H + HRDLK N+LL ++G L D GS + + S
Sbjct: 125 ILWLLLGICRGLEAIHAKG--YAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGS-- 180
Query: 208 AQRRAL-VEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE-- 264
R+AL +++ + T YR PE+ + S+ I E+ D+W+LGC+LY + F + P++
Sbjct: 181 --RQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMV 238
Query: 265 ----DGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEI 316
D L + N + SIP + L+ +M+ V+P +R I ++ QL+ +
Sbjct: 239 FQKGDSVALAVQN-QLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEAL 293
>gi|40549435 transmembrane phosphatase with tensin homology isoform
gamma [Homo sapiens]
Length = 513
Score = 119 bits (298), Expect = 2e-26
Identities = 63/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++Y+T RI MSFP+ G +S +N I++V FLD KH HY VYNL S R Y P F
Sbjct: 198 DLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 257
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
HNRV P LH + + ++ W+ QD +N+ +HC G + VC+FL
Sbjct: 258 HNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIA 317
Query: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
+ STA+ ++Y F +R G+ PS KRY+ Y +
Sbjct: 318 SEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQV 362
>gi|40549433 transmembrane phosphatase with tensin homology isoform
beta [Homo sapiens]
Length = 533
Score = 119 bits (298), Expect = 2e-26
Identities = 63/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++Y+T RI MSFP+ G +S +N I++V FLD KH HY VYNL S R Y P F
Sbjct: 218 DLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 277
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
HNRV P LH + + ++ W+ QD +N+ +HC G + VC+FL
Sbjct: 278 HNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIA 337
Query: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
+ STA+ ++Y F +R G+ PS KRY+ Y +
Sbjct: 338 SEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQV 382
>gi|109689707 transmembrane phosphatase with tensin homology isoform
alpha [Homo sapiens]
Length = 551
Score = 119 bits (298), Expect = 2e-26
Identities = 63/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++Y+T RI MSFP+ G +S +N I++V FLD KH HY VYNL S R Y P F
Sbjct: 236 DLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 295
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
HNRV P LH + + ++ W+ QD +N+ +HC G + VC+FL
Sbjct: 296 HNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIA 355
Query: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
+ STA+ ++Y F +R G+ PS KRY+ Y +
Sbjct: 356 SEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQV 400
>gi|73765544 phosphatase and tensin homolog [Homo sapiens]
Length = 403
Score = 116 bits (291), Expect = 1e-25
Identities = 94/394 (23%), Positives = 168/394 (42%), Gaps = 41/394 (10%)
Query: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
DLD++YI I M FPAE +E +NNI+DV FLDSKH HY +YNL + R Y ++F
Sbjct: 22 DLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF 81
Query: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
+ RV++ + P L + C ++ WL +D +V +HC G+ + V +C++L
Sbjct: 82 NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLH 141
Query: 526 CRLFSTAEAAVYMFS--MKRCPPGIW-PSHKRYIEYMCDMVAEEPITPHSKPILVRAVVM 582
F A+ A+ + R G+ PS +RY+ Y + + + +L ++
Sbjct: 142 RGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYV-YYYSYLLKNHLDYRPVALLFHKMMF 200
Query: 583 TPVPLFS-----KQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQ 637
+P+FS Q C+ ++Y + + ++ DK F+ P + V
Sbjct: 201 ETIPMFSGGTCNPQFVVCQLKVKIYSSN---SGPTRREDKFMYFE-------FPQPLPVC 250
Query: 638 GDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAK------------ 685
GD+ + +H ++ + + KMF +T F+P T + +
Sbjct: 251 GDIKVEFFHKQNKM-------LKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSI 303
Query: 686 YDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDI 745
++ D ++Y L +++ +D+ +R P N ++ K + +
Sbjct: 304 CSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSP--NFKVKLYFTKTVEEPSNPEASS 361
Query: 746 LSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSD 779
+ +P D PE EP D D
Sbjct: 362 STSVTPDVSDNEPDHYRYSDTTDSDPENEPFDED 395
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 113 bits (282), Expect = 1e-24
Identities = 81/269 (30%), Positives = 128/269 (47%), Gaps = 32/269 (11%)
Query: 42 VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQF 101
V R++ EG F Q S + +A+K + + N ++ + HPNIV F
Sbjct: 6 VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
Query: 102 CSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 160
+ES + ++ E C G L++ +K+ + + D +L F Q C V
Sbjct: 66 --------KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK-LFPEDMILNWFTQMCLGVN 116
Query: 161 HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITR 220
H+H+++ ++HRD+K +N+ L+ G +KL DFGSA +S+ ++ T
Sbjct: 117 HIHKKR--VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFA------------CTY 162
Query: 221 NTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA----KLRIVNGKY 276
TP Y PEI + N P K DIW+LGCILY LC +HPF+ + L++ G
Sbjct: 163 VGTPYYVPPEI---WENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCI 219
Query: 277 SIPPHDTQYTVFHSLIRAMLQVNPEERLS 305
S P Y + L++ M + NP R S
Sbjct: 220 SPLPSHYSYEL-QFLVKQMFKRNPSHRPS 247
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 113 bits (282), Expect = 1e-24
Identities = 81/269 (30%), Positives = 128/269 (47%), Gaps = 32/269 (11%)
Query: 42 VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQF 101
V R++ EG F Q S + +A+K + + N ++ + HPNIV F
Sbjct: 6 VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
Query: 102 CSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 160
+ES + ++ E C G L++ +K+ + + D +L F Q C V
Sbjct: 66 --------KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK-LFPEDMILNWFTQMCLGVN 116
Query: 161 HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITR 220
H+H+++ ++HRD+K +N+ L+ G +KL DFGSA +S+ ++ T
Sbjct: 117 HIHKKR--VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFA------------CTY 162
Query: 221 NTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA----KLRIVNGKY 276
TP Y PEI + N P K DIW+LGCILY LC +HPF+ + L++ G
Sbjct: 163 VGTPYYVPPEI---WENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCI 219
Query: 277 SIPPHDTQYTVFHSLIRAMLQVNPEERLS 305
S P Y + L++ M + NP R S
Sbjct: 220 SPLPSHYSYEL-QFLVKQMFKRNPSHRPS 247
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 113 bits (282), Expect = 1e-24
Identities = 81/269 (30%), Positives = 128/269 (47%), Gaps = 32/269 (11%)
Query: 42 VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQF 101
V R++ EG F Q S + +A+K + + N ++ + HPNIV F
Sbjct: 6 VLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAF 65
Query: 102 CSAASIGKEESDTGQAEFLLLTELCKG-QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 160
+ES + ++ E C G L++ +K+ + + D +L F Q C V
Sbjct: 66 --------KESFEAEGHLYIVMEYCDGGDLMQKIKQQKGK-LFPEDMILNWFTQMCLGVN 116
Query: 161 HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITR 220
H+H+++ ++HRD+K +N+ L+ G +KL DFGSA +S+ ++ T
Sbjct: 117 HIHKKR--VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFA------------CTY 162
Query: 221 NTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA----KLRIVNGKY 276
TP Y PEI + N P K DIW+LGCILY LC +HPF+ + L++ G
Sbjct: 163 VGTPYYVPPEI---WENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCI 219
Query: 277 SIPPHDTQYTVFHSLIRAMLQVNPEERLS 305
S P Y + L++ M + NP R S
Sbjct: 220 SPLPSHYSYEL-QFLVKQMFKRNPSHRPS 247
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 110 bits (274), Expect = 1e-23
Identities = 83/276 (30%), Positives = 132/276 (47%), Gaps = 34/276 (12%)
Query: 44 RVLAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFC 102
RV+ +G + V + G++Y +K+L L N + R ++ + HPNIV +
Sbjct: 10 RVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY- 68
Query: 103 SAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDT-VLKIFYQTCRAVQH 161
KE + G ++ C+G + + K E +G L + V++ F Q A+Q+
Sbjct: 69 ------KESWEGGDGLLYIVMGFCEGGDL-YRKLKEQKGQLLPENQVVEWFVQIAMALQY 121
Query: 162 MHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRN 221
+H + I+HRDLK +N+ L+ IK+ D G A + ++ D + T
Sbjct: 122 LHEKH--ILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMA------------STLI 167
Query: 222 TTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE----DGAKLRIVNGKYS 277
TP Y +PE L+SN P K D+WALGC +Y + +H F + RI+ GK
Sbjct: 168 GTPYYMSPE---LFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGK-- 222
Query: 278 IPPHDTQYT-VFHSLIRAMLQVNPEERLSIAEVVHQ 312
+PP Y+ LIR ML PEER S+ ++ Q
Sbjct: 223 LPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQ 258
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 102 bits (253), Expect = 3e-21
Identities = 89/302 (29%), Positives = 142/302 (47%), Gaps = 42/302 (13%)
Query: 42 VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEE--EKNRAIIQEVCFMKKLSGHPNIV 99
V + + +G F Y A+ + +K + + ++ A +EV ++K+ HPNIV
Sbjct: 6 VIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK-HPNIV 64
Query: 100 QFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKME-SRGPL-SCDTVLKIFYQTCR 157
F + S ++ E C G + +K++ RG L S D +L F Q
Sbjct: 65 AFFN--------SFQENGRLFIVMEYCDGG--DLMKRINRQRGVLFSEDQILGWFVQISL 114
Query: 158 AVQHMHRQKPPIIHRDLKVENLLLSNQGTI-KLCDFGSATTISHYPDYSWSAQRRALVEE 216
++H+H +K I+HRD+K +N+ LS G + KL DFG A +++ +E
Sbjct: 115 GLKHIHDRK--ILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNS------------MEL 160
Query: 217 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDG----AKLRIV 272
T TP Y +PEI N P K DIW+LGC+LY LC +HPFE L+I
Sbjct: 161 ARTCIGTPYYLSPEICQ---NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKIC 217
Query: 273 NGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELL 332
++ P HSLI + QV+P +R SI ++ + N+ PK E++
Sbjct: 218 QAHFA-PISPGFSRELHSLISQLFQVSPRDRPSINSILKR----PFLENLIPKYLTPEVI 272
Query: 333 EQ 334
++
Sbjct: 273 QE 274
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 101 bits (252), Expect = 4e-21
Identities = 81/277 (29%), Positives = 135/277 (48%), Gaps = 33/277 (11%)
Query: 39 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL--LSNEEEKNRAIIQEVCFMKKLSGHP 96
+ V ++ EG F VY+ + S + ALK + L E++ R + +E+ M+ L HP
Sbjct: 3 KYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLR-HP 61
Query: 97 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 156
NIV + KE +++T+ +G+L + L E G L D V I Q
Sbjct: 62 NIVHMLDSFETDKE--------VVVVTDYAEGELFQIL---EDDGKLPEDQVQAIAAQLV 110
Query: 157 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 216
A+ ++H + I+HRD+K +N+LL+ G IKLCDFG A +S +V
Sbjct: 111 SALYYLHSHR--ILHRDMKPQNILLAKGGGIKLCDFGFARAMS----------TNTMVLT 158
Query: 217 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKY 276
I TP+Y +PE+++ P D+W++GCILY L PF + ++V+
Sbjct: 159 SI--KGTPLYMSPELVE---ERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLIL 213
Query: 277 SIPPH--DTQYTVFHSLIRAMLQVNPEERLSIAEVVH 311
P T F + ++ +L +P +RLS ++++
Sbjct: 214 KDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLY 250
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 98.2 bits (243), Expect = 5e-20
Identities = 110/364 (30%), Positives = 163/364 (44%), Gaps = 74/364 (20%)
Query: 42 VRRVLAEGGFAFVYEAQDVGSGREYALK-----RLLSNEEEKNRAIIQEVCFMKKLSGHP 96
+ R L +G FA V A+ + + A+K RL S+ EK I +EV MK L+ HP
Sbjct: 29 IERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEK---IYREVQLMKLLN-HP 84
Query: 97 NIVQFCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQT 155
+I++ E D ++TE K G++ ++L S G LS + K F+Q
Sbjct: 85 HIIKLYQVM----ETKDM----LYIVTEFAKNGEMFDYLT---SNGHLSENEARKKFWQI 133
Query: 156 CRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTI-SHYPDYSWSAQRRALV 214
AV++ H I+HRDLK ENLLL IKL DFG S P +W
Sbjct: 134 LSAVEYCHDHH--IVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCG------ 185
Query: 215 EEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----- 269
+P Y PE+ + G + DIW+LG +LY+L PF DG L
Sbjct: 186 --------SPPYAAPEVFE--GKEYEGPQLDIWSLGVVLYVLVCGSLPF-DGPNLPTLRQ 234
Query: 270 RIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPIT 329
R++ G++ IP +Q SLIR ML V+P R++IA+ + Q + + A +
Sbjct: 235 RVLEGRFRIPFFMSQDC--ESLIRRMLVVDPARRITIAQ-IRQHRWMRAEPCL------- 284
Query: 330 ELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNL 389
P P PA S +S L +YD+ G + L +R +L
Sbjct: 285 ------------------PGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESL 326
Query: 390 KDTS 393
+++S
Sbjct: 327 QNSS 330
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 95.5 bits (236), Expect = 3e-19
Identities = 83/277 (29%), Positives = 134/277 (48%), Gaps = 38/277 (13%)
Query: 41 RVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKN--RAIIQEVCFMKKLSGHPNI 98
R+ R + +G FA V A+ + +GRE A+K + + + + + +EV MK L+ HPNI
Sbjct: 60 RLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLN-HPNI 118
Query: 99 VQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRA 158
V+ E +T + +L++ G++ ++L S G + F Q A
Sbjct: 119 VKLF-------EVIETEKTLYLVMEYASAGEVFDYLV---SHGRMKEKEARAKFRQIVSA 168
Query: 159 VQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI 218
V + H++ I+HRDLK ENLLL + IK+ DFG + + L +
Sbjct: 169 VHYCHQKN--IVHRDLKAENLLLDAEANIKIADFGFSNEFT-------------LGSKLD 213
Query: 219 TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL-----RIVN 273
T +P Y PE+ G + DIW+LG ILY L PF DG L R++
Sbjct: 214 TFCGSPPYAAPELFQ--GKKYDGPEVDIWSLGVILYTLVSGSLPF-DGHNLKELRERVLR 270
Query: 274 GKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVV 310
GKY +P + T S++R L +NP +R ++ +++
Sbjct: 271 GKYRVPFY--MSTDCESILRRFLVLNPAKRCTLEQIM 305
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 92.0 bits (227), Expect = 3e-18
Identities = 76/286 (26%), Positives = 131/286 (45%), Gaps = 33/286 (11%)
Query: 44 RVLAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFC 102
RV+ G F V+ + +K++ + ++ R Q C + KL HPN++++
Sbjct: 8 RVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYY 67
Query: 103 SAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHM 162
E +A + + G L EF++K L +T+L F Q A+ H+
Sbjct: 68 -------ENFLEDKALMIAMEYAPGGTLAEFIQK-RCNSLLEEETILHFFVQILLALHHV 119
Query: 163 HRQKPPIIHRDLKVENLLLS-NQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRN 221
H I+HRDLK +N+LL ++ +K+ DFG + +S + T
Sbjct: 120 HTHL--ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK-------------SKAYTVV 164
Query: 222 TTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE----DGAKLRIVNGKYS 277
TP Y +PE+ + P +K DIWALGC+LY L + FE L+I++G ++
Sbjct: 165 GTPCYISPELCE---GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFA 221
Query: 278 IPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVN 323
P D L+ ++L + P +R ++ ++ Q I A N++
Sbjct: 222 -PISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLH 266
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 92.0 bits (227), Expect = 3e-18
Identities = 85/272 (31%), Positives = 128/272 (47%), Gaps = 36/272 (13%)
Query: 41 RVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSN--EEEKNRAIIQEVCFMKKLSGHPNI 98
R+R + G F+ V + + A+K L +++ R + +E+ M+KL HPNI
Sbjct: 75 RIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLH-HPNI 133
Query: 99 VQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRA 158
++ ++ L+ E G E K+ + G LS IF Q A
Sbjct: 134 IRLYEVVET--------LSKLHLVMEYAGGG--ELFGKISTEGKLSEPESKLIFSQIVSA 183
Query: 159 VQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI 218
V+HMH + IIHRDLK EN+ ++ +K+ DFG +T +++ ++
Sbjct: 184 VKHMHENQ--IIHRDLKAENVFYTSNTCVKVGDFGFSTV----------SKKGEMLN--- 228
Query: 219 TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF--EDGAKLR--IVNG 274
T +P Y PE+ IG DIWALG +LY + PF E AKL+ I+ G
Sbjct: 229 TFCGSPPYAAPEL--FRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEG 286
Query: 275 KYSIPPHDTQYTVFHSLIRAMLQVNPEERLSI 306
YS+PPH ++ H LIR +LQ P ER I
Sbjct: 287 TYSVPPHVSE--PCHRLIRGVLQQIPTERYGI 316
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 91.7 bits (226), Expect = 4e-18
Identities = 67/217 (30%), Positives = 108/217 (49%), Gaps = 22/217 (10%)
Query: 39 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA--IIQEVCFMKKLSGHP 96
R +RR L +G + V++A D +G A+K++ +K A +E+ +++ HP
Sbjct: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
Query: 97 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 156
NI+ S + + E+D + L+ E L ++K G L V IFYQ
Sbjct: 72 NII---SLLDVIRAENDR---DIYLVFEFMDTDLNAVIRK---GGLLQDVHVRSIFYQLL 122
Query: 157 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 216
RA + +H ++HRD K N+LL T+KLCDFG A ++ P+ + +A+ E
Sbjct: 123 RATRFLHSGH--VVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPE---GPEDQAVTEY 177
Query: 217 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 253
TR YR PE++ + +G D+W+LGCIL
Sbjct: 178 VATR----WYRAPEVLLSSHRYTLG--VDMWSLGCIL 208
Score = 32.7 bits (73), Expect = 2.3
Identities = 32/100 (32%), Positives = 36/100 (36%), Gaps = 16/100 (16%)
Query: 827 EVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGL 886
E EG SP + +PRADP+ P TP P P PQ
Sbjct: 355 EKGPEGVSPSQAHLHKPRADPQLPS--------------RTPVQGPRPRPQSSPGHDPAE 400
Query: 887 HSEVGAGPAVPPQACKAPSSNTDLLSCLLGPPEAASQGPP 926
H A VP Q AP T LL PP A + PP
Sbjct: 401 HESPRAAKNVPRQN-SAPLLQTALLGNGERPP-GAKEAPP 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,266,893
Number of Sequences: 37866
Number of extensions: 3520771
Number of successful extensions: 22762
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 519
Number of HSP's successfully gapped in prelim test: 1225
Number of HSP's that attempted gapping in prelim test: 16335
Number of HSP's gapped (non-prelim): 5945
length of query: 1311
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1197
effective length of database: 13,930,794
effective search space: 16675160418
effective search space used: 16675160418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.