Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 157168355
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157168355 CD22 molecule [Homo sapiens]
(847 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157168355 CD22 molecule [Homo sapiens] 1766 0.0
gi|13489095 sialoadhesin precursor [Homo sapiens] 178 2e-44
gi|98986445 carcinoembryonic antigen-related cell adhesion molec... 140 5e-33
gi|11225258 myelin associated glycoprotein isoform a precursor [... 115 2e-25
gi|18104957 myelin associated glycoprotein isoform b precursor [... 115 2e-25
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 109 1e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 109 1e-23
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 109 1e-23
gi|110349719 titin isoform N2-A [Homo sapiens] 107 5e-23
gi|118572606 hemicentin 1 [Homo sapiens] 107 6e-23
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 103 7e-22
gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens] 99 2e-20
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 97 5e-20
gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Ho... 95 3e-19
gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens] 95 3e-19
gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo ... 93 1e-18
gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens] 91 3e-18
gi|4758822 nephrin precursor [Homo sapiens] 91 4e-18
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 90 8e-18
gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens] 90 1e-17
gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Ho... 89 2e-17
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 87 5e-17
gi|157694526 Fc receptor-like 5 [Homo sapiens] 86 1e-16
gi|16506826 sialic acid binding immunoglobulin-like lectin-like ... 86 2e-16
gi|16506828 sialic acid binding immunoglobulin-like lectin-like ... 86 2e-16
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 84 4e-16
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 84 4e-16
gi|15147240 brother of CDO [Homo sapiens] 84 5e-16
gi|19743806 roundabout 1 isoform b [Homo sapiens] 83 9e-16
gi|4506569 roundabout 1 isoform a [Homo sapiens] 83 9e-16
>gi|157168355 CD22 molecule [Homo sapiens]
Length = 847
Score = 1766 bits (4573), Expect = 0.0
Identities = 847/847 (100%), Positives = 847/847 (100%)
Query: 1 MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH 60
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH
Sbjct: 1 MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH 60
Query: 61 NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR 120
NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR
Sbjct: 61 NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR 120
Query: 121 MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG 180
MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG
Sbjct: 121 MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG 180
Query: 181 VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH 240
VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH
Sbjct: 181 VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH 240
Query: 241 TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT 300
TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT
Sbjct: 241 TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT 300
Query: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL 360
KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL
Sbjct: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL 360
Query: 361 PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK 420
PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK
Sbjct: 361 PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK 420
Query: 421 KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT 480
KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT
Sbjct: 421 KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT 480
Query: 481 TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ 540
TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ
Sbjct: 481 TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ 540
Query: 541 FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM 600
FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM
Sbjct: 541 FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM 600
Query: 601 SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ 660
SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ
Sbjct: 601 SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ 660
Query: 661 GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG 720
GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG
Sbjct: 661 GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG 720
Query: 721 LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES 780
LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES
Sbjct: 721 LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES 780
Query: 781 SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV 840
SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV
Sbjct: 781 SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV 840
Query: 841 DYVILKH 847
DYVILKH
Sbjct: 841 DYVILKH 847
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 178 bits (452), Expect = 2e-44
Identities = 174/659 (26%), Positives = 286/659 (43%), Gaps = 73/659 (11%)
Query: 6 PWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLE-----SFILFH 60
P LLLL + A + W P+ + +G+C+ IPC + + D+E + I ++
Sbjct: 5 PKLLLLASFFPA--GQASWGVSSPQDVQGVKGSCLLIPCIF-SFPADVEVPDGITAIWYY 61
Query: 61 NPEYNKNT-SKFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIHPVHLNDSGQLG 118
+ + S +L E+ G R +F+G+ +++ C L + + DSG
Sbjct: 62 DYSGQRQVVSHSADPKLVEARFRG-------RTEFMGNPEHRVCNLLLKDLQPEDSGSYN 114
Query: 119 LRME-SKTEKW--MERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQ 175
R E S+ +W ++ + V+E P P I P E+ E EV C + C ++LQ
Sbjct: 115 FRFEISEVNRWSDVKGTLVTVTEEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQVRLQ 174
Query: 176 WLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQ 235
W + P R S V L + W HG+I+ CQL A+ + + +
Sbjct: 175 WQGQD-PARSVTFNSQKFEPTGVGHLETLHMAMSWQDHGRILRCQLSVANHR--AQSEIH 231
Query: 236 LNVKHTPK-LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTL 294
L VK+ PK ++I ++PS + G+ VT+TC+V+SS P +++ WLKDG L+ + T L
Sbjct: 232 LQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTK-TGVL 290
Query: 295 NLREVTKDQSGKYCCQVSNDVG----PGRSEEVFL-QVQYAPEPSTVQILHSPAVEGSQV 349
+L + +G Y CQ N VG P S +F+ +VQ +P P +E V
Sbjct: 291 HLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPA--------GPILENQTV 342
Query: 350 EFLCMSLANPLPTN--YTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQR 407
+C + N P++ Y+WY N ++ + + G Y C +N+ G+ +
Sbjct: 343 TLVC-NTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERS 401
Query: 408 GPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPH-------- 459
GP + V +PP +T V+ + + G L C+ S + H
Sbjct: 402 GP-VSVVVNHPP--LTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGD 458
Query: 460 -------GAWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511
P+ L+I+++ D+ C+A NS + S + + A
Sbjct: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAAR-----L 513
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSY 569
I P +E+ G +V+L C S + +F W NG LL G S L + S DAGSY
Sbjct: 514 LISPAAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALLHEGPGSSLLLPAASSTDAGSY 573
Query: 570 SCWVNNSIGQTA-SKAWTLEVLYAPRR----LRVSMSPGDQVMEGKSATLTCESDANPP 623
C + + S L VLY PR+ R+ + G+ L C D++PP
Sbjct: 574 HCRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAG-AGAGRRGLLLCRVDSDPP 631
Score = 102 bits (254), Expect = 1e-21
Identities = 128/516 (24%), Positives = 204/516 (39%), Gaps = 90/516 (17%)
Query: 246 IKVTPSDAIVREGDSVTMTCEVS---SSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKD 302
+ + PS + +EG +TC VS + +P SW ++G + T+ L V +
Sbjct: 711 LAIAPSHTL-QEGTEANLTCNVSREAAGSP--ANFSWFRNGVLWAQGPLETVTLLPVART 767
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362
+ Y C++ + G S V L V Y P+ + L +G F+C + PL
Sbjct: 768 DAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMG-QGHMALFICTVDSRPLAL 826
Query: 363 NYTWY-------------HNGKEMQGRTEE---KVHIPKILPWHAGTYSCVAENILGTGQ 406
++ + Q + E K+ + ++ +G+Y C A N+LG+
Sbjct: 827 LALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSN 886
Query: 407 RG-----PGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG- 460
GA + V P+ ++EG V LSC ++ P T Y W G
Sbjct: 887 TSLFFQVRGAWVQVSPSPE-----------LQEGQAVVLSCQVHTGVPEGTSYRWYRDGQ 935
Query: 461 AWEEPSLGVLKIQNVGWDNTTI----ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPL 516
+E + L+ + A A ++ S A+P++L+V YAPR V + L
Sbjct: 936 PLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHV---TLTTL 992
Query: 517 SEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--------------------- 555
+ G L C S P +++ RL+ Q
Sbjct: 993 MDTGPGRLGLLLCRVDSDPPAQLRLL--HGDRLVASTLQGVGGPEGSSPRLHVAVAPNTL 1050
Query: 556 -LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATL 614
L ED G Y C +N++GQ ++ A + + + V + PG V EG+ L
Sbjct: 1051 RLEIHGAMLEDEGVYICEASNTLGQASASA-----DFDAQAVNVQVWPGATVREGQLVNL 1105
Query: 615 TC-ESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG-KGRSP- 671
TC +P YTW+ Q L HS + L V V+ + +Y C VG GR+P
Sbjct: 1106 TCLVWTTHPAQLTYTWYQDGQQRLDAHS--IPLPNVTVRDATSYRC----GVGPPGRAPR 1159
Query: 672 LS---TLTVYYSPETIGRRVAVGLGSCLAILILAIC 704
LS TL V Y+P + R+ L S L L +C
Sbjct: 1160 LSRPITLDVLYAPRNL--RLTYLLESHGGQLALVLC 1193
Score = 95.9 bits (237), Expect = 1e-19
Identities = 123/480 (25%), Positives = 198/480 (41%), Gaps = 71/480 (14%)
Query: 244 LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQ 303
+ ++V P A VREG V +TC V +++P T +W +DG ++ + ++ L VT
Sbjct: 1087 VNVQVWPG-ATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRD 1143
Query: 304 SGKYCCQVSNDVGPGR----SEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANP 359
+ Y C V PGR S + L V YAP +++ + G Q+ + ++ +
Sbjct: 1144 ATSYRCGVG---PPGRAPRLSRPITLDVLYAPR--NLRLTYLLESHGGQLALVLCTVDSR 1198
Query: 360 LPTNYTWYHNGKEMQGRTEEKVHIPKIL--------PWHAGTYSCVAENILGTGQRGPGA 411
P H G+ + T V P L P G YSC A + L GQ
Sbjct: 1199 PPAQLALSHAGRLLASSTAASV--PNTLRLELRGPQPRDEGFYSCSARSPL--GQANTSL 1254
Query: 412 ELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW--EEPSLGV 469
EL ++ V ++ + EG +T++C +++ + T Y W +G W E P+ +
Sbjct: 1255 ELRLE----GVRVILAPEAAVPEGAPITVTCADPAAH-APTLYTWYHNGRWLQEGPAASL 1309
Query: 470 LKIQNVGWDNTTIACAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQ 528
+ +C A ++ + +S P AL V YAP+D + + + + + +Q
Sbjct: 1310 SFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR---DSRARSMAVIQ 1366
Query: 529 CDFSSSHPKEVQFFWEKNGRLLGKES-------------------QLNFDSISPEDAGSY 569
C S P E+ +G++L S +L + P +Y
Sbjct: 1367 CTVDSEPPAELAL--SHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423
Query: 570 SCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV--SH 626
C N +G + S L+V A RV PG V EG + L+C P PV S
Sbjct: 1424 VCTAQNLLG-SISTIGRLQVEGA----RVVAEPGLDVPEGAALNLSCRLLGGPGPVGNST 1478
Query: 627 YTWFDWNNQSLPYHSQ---KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPET 683
+ WF WN++ L H++ L V +G Y C G S L V Y P+T
Sbjct: 1479 FAWF-WNDRRL--HAEPVPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKT 1535
Score = 93.2 bits (230), Expect = 9e-19
Identities = 114/420 (27%), Positives = 180/420 (42%), Gaps = 53/420 (12%)
Query: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSE-EVFLQVQYAPEPSTVQILHSPA----VEGS 347
TL++ +D CQ+S V R++ E+ LQV+YAP+ V+IL SP+ + G
Sbjct: 201 TLHMAMSWQDHGRILRCQLS--VANHRAQSEIHLQVKYAPKG--VKILLSPSGRNILPGE 256
Query: 348 QVEFLC-MSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406
V C ++ + P ++ W +G +Q +T +H+P+ AG Y+C AEN +G+
Sbjct: 257 LVTLTCQVNSSYPAVSSIKWLKDGVRLQTKTGV-LHLPQAAWSDAGVYTCQAENGVGS-L 314
Query: 407 RGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-KPHGAWEEP 465
P L + +V+ PI E TVTL CN + PS RY W K H E+
Sbjct: 315 VSPPISLHIFMAEVQVSPA----GPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDA 370
Query: 466 SLGVLKIQNVGWDNTTIA-CAACNSWCSWAS-PVALNVQYAPRDVRVRKIKPLSEIHSGN 523
L++ +T C N S S PV++ V + P + E +G
Sbjct: 371 HSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL---TPVLTAFLETQAGL 427
Query: 524 SVSLQCDFSSSHPKEVQFFWEKNGRLLGKES------------------QLNFDSISPED 565
L C S + G +L S +L + D
Sbjct: 428 VGILHCSVVSEPLATLVL--SHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETD 485
Query: 566 AGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PV 624
+G Y C NS+G S TL+ + R+ +SP +V+EG++ TL+C S +P P
Sbjct: 486 SGEYKCSATNSLGNATS---TLD--FHANAARLLISPAAEVVEGQAVTLSCRSGLSPTPD 540
Query: 625 SHYTWFDWNNQSLPYH--SQKLRLEPVKVQHSGAYWCQGTNS-VGKGRSPLSTLTVYYSP 681
+ ++W+ N +L + L L +G+Y C+ + G S + LTV Y P
Sbjct: 541 ARFSWY--LNGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLTVLYPP 598
Score = 84.3 bits (207), Expect = 4e-16
Identities = 136/593 (22%), Positives = 234/593 (39%), Gaps = 88/593 (14%)
Query: 71 FDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130
F G L ++ +VPS R Q + N + L + + L DSG R E+
Sbjct: 830 FHGEHLLATSLGPQVPSHG-RFQAKAEAN-SLKLEVRELGLGDSGSY--RCEATNVLGSS 885
Query: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYP--IQLQWLLEGVPMRQAAV 188
L R + PE+QE Q V L+C ++ G P +W +G P+++
Sbjct: 886 NTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVH---TGVPEGTSYRWYRDGQPLQE--- 939
Query: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSN--DTVQLNVKHTPKLEI 246
STS T++ + + + ++H CQ Q A G ++ + L+V + P+
Sbjct: 940 -STSATLRF----AAITLTQAGAYH-----CQAQ-APGSATTSLAAPISLHVSYAPRHVT 988
Query: 247 KVTPSDAIVREGDSVTMTCEVSSSNP--------EYTTVSWLK-----DGTSLK-----K 288
T D G + C V S P + S L+ +G+S +
Sbjct: 989 LTTLMD--TGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046
Query: 289 QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGS 347
NT L + + G Y C+ SN +G + + + VQ+ V EG
Sbjct: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLG-----QASASADFDAQAVNVQVWPGATVREGQ 1101
Query: 348 QVEFLCMS-LANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ 406
V C+ +P YTWY +G+ Q + +P + A +Y C G G
Sbjct: 1102 LVNLTCLVWTTHPAQLTYTWYQDGQ--QRLDAHSIPLPNVTVRDATSYRC------GVGP 1153
Query: 407 RGPGAE------LDVQYPPK--KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
G LDV Y P+ ++T ++++ G + C +S P+
Sbjct: 1154 PGRAPRLSRPITLDVLYAPRNLRLTYLLES----HGGQLALVLCTVDSRPPAQLALSHAG 1209
Query: 459 HGAWEEPSLGV---LKIQNVG---WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
+ V L+++ G D +C+A + + + L ++ VRV
Sbjct: 1210 RLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE----GVRV-I 1264
Query: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL--GKESQLNFDSISPEDAGSYS 570
+ P + + G +++ C ++H + + W NGR L G + L+F + AG+YS
Sbjct: 1265 LAPEAAVPEGAPITVTCADPAAHAPTL-YTWYHNGRWLQEGPAASLSFLVATRAHAGAYS 1323
Query: 571 CWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
C ++ G +S+ L+VLYAP+ +S + A + C D+ PP
Sbjct: 1324 CQAQDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR--SMAVIQCTVDSEPP 1374
Score = 84.0 bits (206), Expect = 5e-16
Identities = 57/191 (29%), Positives = 87/191 (45%), Gaps = 6/191 (3%)
Query: 495 SPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG-RLLGKE 553
S + L V+YAP+ V++ I G V+L C +SS+P W K+G RL K
Sbjct: 228 SEIHLQVKYAPKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVRLQTKT 287
Query: 554 SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT 613
L+ + DAG Y+C N +G S +L + A V +SP ++E ++ T
Sbjct: 288 GVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAGPILENQTVT 343
Query: 614 LTCESDANPPVS-HYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672
L C + P Y+W+ + HS LRL +G Y+C+ N G RS
Sbjct: 344 LVCNTPNEAPSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGP 403
Query: 673 STLTVYYSPET 683
++ V + P T
Sbjct: 404 VSVVVNHPPLT 414
Score = 68.6 bits (166), Expect = 2e-11
Identities = 115/526 (21%), Positives = 192/526 (36%), Gaps = 85/526 (16%)
Query: 150 EIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209
E+ E Q VTL+C S + W L G + + +S L S +
Sbjct: 520 EVVEGQAVTLSCRSGLSPTP-DARFSWYLNGALLHEGPGSSLLLPAASS--------TDA 570
Query: 210 WSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD---AIVREGDSVTMTCE 266
S+H C+ +D + L V + P+ T D A G + C
Sbjct: 571 GSYH-----CRARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCR 625
Query: 267 VSSSNP--------EYTTVSWLKDGTSL-------------KKQNTFTLNLREVTKDQSG 305
V S P + + L G K N + + ++ G
Sbjct: 626 VDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEG 685
Query: 306 KYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGSQVEFLC--MSLANPLPT 362
Y C+ SN +G + F + + + I S + EG++ C A P
Sbjct: 686 LYLCEASNALGNASTSATF-----NGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPA 740
Query: 363 NYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK- 421
N++W+ NG E V + + A Y+C G Q L V YPP +
Sbjct: 741 NFSWFRNGVLWAQGPLETVTLLPVARTDAALYACRILTEAG-AQLSTPVLLSVLYPPDRP 799
Query: 422 ----------------VTTVIQNPMPIR---EGDTVTLSCNYNSSNPSVTRYEWKPHGAW 462
+ TV P+ + G+ + L+ + PS R++ K
Sbjct: 800 KLSALLDMGQGHMALFICTVDSRPLALLALFHGEHL-LATSLGPQVPSHGRFQAK----- 853
Query: 463 EEPSLGVLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521
E + L+++ +G D+ + C A N S + + V+ A ++ P E+
Sbjct: 854 AEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGA-----WVQVSPSPELQE 908
Query: 522 GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ--LNFDSISPEDAGSYSCWVNNSIGQ 579
G +V L C + P+ + W ++G+ L + + L F +I+ AG+Y C
Sbjct: 909 GQAVVLSCQVHTGVPEGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSA 968
Query: 580 TASKA--WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
T S A +L V YAPR V+++ G+ L C D++PP
Sbjct: 969 TTSLAAPISLHVSYAPR--HVTLTTLMDTGPGRLGLLLCRVDSDPP 1012
Score = 57.4 bits (137), Expect = 6e-08
Identities = 82/383 (21%), Positives = 144/383 (37%), Gaps = 72/383 (18%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQV 311
+A V EG +T+TC +++ T +W +G L++ +L+ T+ +G Y CQ
Sbjct: 1268 EAAVPEGAPITVTCADPAAHAP-TLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA 1326
Query: 312 SNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK 371
+ G S LQV YAP+ + + S C + P P H+GK
Sbjct: 1327 QDAQGTRSSRPAALQVLYAPQDAVLSSFRDSRAR-SMAVIQCTVDSEP-PAELALSHDGK 1384
Query: 372 EMQGRTEEKVHI------------------PKILPWHAGTYSCVAENILGTGQRGPGAEL 413
+ T VH + +P TY C A+N+LG+ ++
Sbjct: 1385 VL--ATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQV 1442
Query: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV--TRYEWKPHGAWEEPSLGVLK 471
+ V + + + EG + LSC V + + W W + L
Sbjct: 1443 E------GARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAW----FWNDRRLHAEP 1492
Query: 472 IQNVGWDNTTIA-------CAACNSWCSWASPVALNVQYAPR------------------ 506
+ + + + A A + + ++PV L V Y P+
Sbjct: 1493 VPTLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGIL 1552
Query: 507 DVRVRKIKPLSE--IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFD--SIS 562
D RV +PL+ +H G+ + +SS P+ E + +L + L D ++
Sbjct: 1553 DCRVDS-EPLASLTLHLGSRL-----VASSQPQGAPA--EPHIHVLASPNALRVDIEALR 1604
Query: 563 PEDAGSYSCWVNNSIGQTASKAW 585
P D G Y C +N +G ++ +
Sbjct: 1605 PSDQGEYICSASNVLGSASTSTY 1627
>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
5 preproprotein [Homo sapiens]
Length = 702
Score = 140 bits (353), Expect = 5e-33
Identities = 127/460 (27%), Positives = 192/460 (41%), Gaps = 52/460 (11%)
Query: 255 VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK-------KQNTFTLNLREVTKDQSGKY 307
V + D+V TCE + + Y W + SL TL L VT++ + Y
Sbjct: 157 VEDKDAVAFTCEPETQDATYL---WWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASY 213
Query: 308 CCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWY 367
C+ N V RS+ V L V Y P+ T+ L++ G + C + +NP P Y+W+
Sbjct: 214 KCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNP-PAQYSWF 272
Query: 368 HNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQ 427
NG Q + +++ IP I ++G+Y+C A N R + V P K
Sbjct: 273 VNGTFQQ--STQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSN 330
Query: 428 NPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW-EEPSLGVLKIQNVGWDNTTIA--- 483
N P+ + D V L+C N T Y W W SL V + DN T+
Sbjct: 331 NSNPVEDEDAVALTCEPEIQN---TTYLW-----WVNNQSLPVSPRLQLSNDNRTLTLLS 382
Query: 484 ----------CAACNSW-CSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFS 532
C N + PV LNV Y P D + + G ++SL C +
Sbjct: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTYYRPGVNLSLSCHAA 440
Query: 533 SSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSI-GQTASKAWTLEVLY 591
S+ P Q+ W +G + +L +I+ +++G Y+C NNS G + + T+ V
Sbjct: 441 SNPP--AQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSA 498
Query: 592 APRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYH--------SQK 643
+ +S + V + + TCE +A + Y W+ N QSLP ++
Sbjct: 499 ELPKPSISSNNSKPVEDKDAVAFTCEPEAQN--TTYLWW-VNGQSLPVSPRLQLSNGNRT 555
Query: 644 LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPET 683
L L V + AY C NSV RS TL V Y P+T
Sbjct: 556 LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT 595
Score = 113 bits (283), Expect = 6e-25
Identities = 120/500 (24%), Positives = 208/500 (41%), Gaps = 58/500 (11%)
Query: 231 NDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN 290
+D+V LNV + P ++P + R G+++ ++C +S+ P SW +GT +Q+
Sbjct: 226 SDSVILNVLYGPDAPT-ISPLNTSYRSGENLNLSCHAASNPP--AQYSWFVNGTF--QQS 280
Query: 291 TFTLNLREVTKDQSGKYCCQVSN-DVGPGRSEEVFLQVQYA--PEPSTVQILHSPAVEGS 347
T L + +T + SG Y CQ N D G R+ + V YA P+P +P +
Sbjct: 281 TQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITV-YAEPPKPFITSNNSNPVEDED 339
Query: 348 QVEFLCM-SLANPLPTNYTWYHNGKEMQ-------GRTEEKVHIPKILPWHAGTYSCVAE 399
V C + N T Y W+ N + + + + + G Y C +
Sbjct: 340 AVALTCEPEIQN---TTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ 396
Query: 400 NILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPH 459
N L P L+V Y P T+ + R G ++LSC+ S+ P+ +Y W
Sbjct: 397 NKLSVDHSDP-VILNVLYGPDD-PTISPSYTYYRPGVNLSLSCHAASNPPA--QYSWLID 452
Query: 460 GAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEI 519
G ++ + + I N+ N+ + N+ S S + + + V P I
Sbjct: 453 GNIQQHTQELF-ISNITEKNSGLYTCQANNSASGHSRTTV------KTITVSAELPKPSI 505
Query: 520 HSGNS--------VSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDS---------IS 562
S NS V+ C+ + + W NG+ L +L + ++
Sbjct: 506 SSNNSKPVEDKDAVAFTCE---PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVT 562
Query: 563 PEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP 622
DA +Y C + NS+ S TL+VLY P +S P + G + L+C S +NP
Sbjct: 563 RNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS-PPDSSYLSGANLNLSCHSASNP 621
Query: 623 PVSHYTWFDWNNQSLP-YHSQKLRLEPVKVQHSGAYWCQGTN-SVGKGRSPLSTLTVYYS 680
+ W +P H+Q L + + ++G Y C +N + G+ S + ++TV S
Sbjct: 622 SPQ----YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSAS 677
Query: 681 PETIGRRVAVGLGSCLAILI 700
+ G +G + +L+
Sbjct: 678 GTSPGLSAGATVGIMIGVLV 697
Score = 111 bits (277), Expect = 3e-24
Identities = 124/496 (25%), Positives = 199/496 (40%), Gaps = 50/496 (10%)
Query: 99 NKNCTLSIHPVHLNDSGQLGLRMESKTE-KWMERIHLNVSERPFPPHIQ-LPPEIQESQE 156
N N TL++ V ND+ ++ + + + LNV P P I L + +
Sbjct: 195 NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGEN 254
Query: 157 VTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKI 216
+ L+C + P Q W + G + ++ L I ++ + +
Sbjct: 255 LNLSC---HAASNPPAQYSWFVNGTFQQ----STQELFIPNITVNNSGSY---------- 297
Query: 217 VTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT 276
TCQ ++D + V P + + V + D+V +TCE N TT
Sbjct: 298 -TCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQN---TT 353
Query: 277 VSWLKDGTSLK-------KQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQY 329
W + SL + TL L VT++ G Y C + N + S+ V L V Y
Sbjct: 354 YLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLY 413
Query: 330 APEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPW 389
P+ T+ ++ G + C + +NP P Y+W +G +Q T+E + I I
Sbjct: 414 GPDDPTISPSYTYYRPGVNLSLSCHAASNP-PAQYSWLIDGN-IQQHTQE-LFISNITEK 470
Query: 390 HAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNP 449
++G Y+C A N R + V K + N P+ + D V +C + N
Sbjct: 471 NSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQN- 529
Query: 450 SVTRYEWKPHGAW--EEPSLGV------LKIQNVGW-DNTTIACAACNSWCSWAS-PVAL 499
T Y W +G P L + L + NV D C NS + S PV L
Sbjct: 530 --TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTL 587
Query: 500 NVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFD 559
+V Y P + P S SG +++L C S+S+P Q+ W NG L
Sbjct: 588 DVLYGPDTPIISP--PDSSYLSGANLNLSCH-SASNPSP-QYSWRINGIPQQHTQVLFIA 643
Query: 560 SISPEDAGSYSCWVNN 575
I+P + G+Y+C+V+N
Sbjct: 644 KITPNNNGTYACFVSN 659
Score = 85.1 bits (209), Expect = 2e-16
Identities = 89/320 (27%), Positives = 127/320 (39%), Gaps = 40/320 (12%)
Query: 99 NKNCTLSIHPVHLNDSGQLGLRMESKTE-KWMERIHLNVSERPFPPHIQLPPEIQESQEV 157
N N TL++ V ND G +++K + + LNV P P I P V
Sbjct: 373 NDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS-PSYTYYRPGV 431
Query: 158 TLTCLLNFSCYGY---PIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHG 214
L+ SC+ P Q WL++G + EL S +
Sbjct: 432 NLS----LSCHAASNPPAQYSWLIDGNIQQHT---------------QELFISNITEKNS 472
Query: 215 KIVTCQLQDADGKFLSNDTVQLNVK-HTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPE 273
+ TCQ ++ + V PK I S V + D+V TCE + N
Sbjct: 473 GLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKP-VEDKDAVAFTCEPEAQN-- 529
Query: 274 YTTVSWLKDGTSLK-------KQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQ 326
TT W +G SL TL L VT++ + Y C + N V RS+ V L
Sbjct: 530 -TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD 588
Query: 327 VQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKI 386
V Y P+ + S + G+ + C S +NP P Y+W NG Q + + I KI
Sbjct: 589 VLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSP-QYSWRINGIPQQ--HTQVLFIAKI 645
Query: 387 LPWHAGTYSCVAENILGTGQ 406
P + GTY+C N L TG+
Sbjct: 646 TPNNNGTYACFVSN-LATGR 664
>gi|11225258 myelin associated glycoprotein isoform a precursor
[Homo sapiens]
Length = 626
Score = 115 bits (288), Expect = 2e-25
Identities = 130/465 (27%), Positives = 198/465 (42%), Gaps = 38/465 (8%)
Query: 16 LAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFIL----FHNPEYNKNTSKF 71
++ S W P ++ A+EG CV IPC + D +L ++ + N Y KN
Sbjct: 14 ISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPD-ELRPAVVHGVWYFNSPYPKNYPPV 72
Query: 72 DGTRLYESTKDGKVPSEQKRVQFLGDKN-KNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130
+++S S Q R + LGD +NCTL + V G+ R +
Sbjct: 73 ----VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYT 128
Query: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWL-LEGVPMRQAAVT 189
+V + P+I +PPE+ EV ++C++ +C +L WL EG + + AV
Sbjct: 129 FSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEG--LGEPAVL 186
Query: 190 STSLTIKSVFTR-SELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
+ + + S L F P +G + CQ + ++VK+ P +
Sbjct: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
Query: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK--QNTFTLNLREVTKDQSGK 306
+ +AI EG V++ C S+ P T W++DGT L++ + L L EVT + G
Sbjct: 247 SSVEAI--EGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGV 302
Query: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLP--TNY 364
Y C N G + V L V YAP TV AVEG V LC + +NP P T +
Sbjct: 303 YACLAENAYGQD-NRTVGLSVMYAPWKPTVNGT-MVAVEGETVSILCSTQSNPDPILTIF 360
Query: 365 TWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTT 424
+ +E ++ +P + P G Y CVAEN GQR L V++ P
Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAEN--QYGQRATAFNLSVEFAP----V 414
Query: 425 VIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGV 469
++ DTV C SNP +P A+E PS V
Sbjct: 415 LLLESHCAAARDTVQCLC-VVKSNP-------EPSVAFELPSRNV 451
Score = 68.2 bits (165), Expect = 3e-11
Identities = 90/324 (27%), Positives = 136/324 (41%), Gaps = 34/324 (10%)
Query: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP-AVEGSQVEF 351
TL L V+ + GKY + D+G G ++ F + +T I+ P V G++VE
Sbjct: 101 TLLLSNVSPELGGKYYFR--GDLG-GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
Query: 352 LCMSLAN--PLPTNYTWY-HNG---KEMQGRTEEK---------VHIPKILPWHAGTYSC 396
CM N L +W H G + GR E +H + C
Sbjct: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
Query: 397 VAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW 456
A T Q A +DV+YPP V + + + EG V+L C +S+ P + W
Sbjct: 218 QASFPNTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLT--W 273
Query: 457 KPHGAWEEPSLG---VLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
G ++ +L+++ V ++ AC A N++ V L+V YAP V
Sbjct: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333
Query: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---NGRLLGKESQLNFDSISPEDAGSY 569
E G +VS+ C S+ + F EK + + E QL ++SPED G Y
Sbjct: 334 TMVAVE---GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
Query: 570 SCWVNNSIGQTASKAWTLEVLYAP 593
C N GQ A+ A+ L V +AP
Sbjct: 391 WCVAENQYGQRAT-AFNLSVEFAP 413
Score = 65.5 bits (158), Expect = 2e-10
Identities = 68/278 (24%), Positives = 119/278 (42%), Gaps = 35/278 (12%)
Query: 429 PMPIREGDTVTLSCNYNSSNPSVT-RYEWKPHGAWEEPS-LGVLKIQNVGWDNTTI---- 482
P + G V +SC + P + W H EP+ LG L+ W ++
Sbjct: 146 PPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205
Query: 483 ----------ACAAC--NSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCD 530
C A N+ + +++V+Y P V + E G+ VSL C
Sbjct: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIE---GSHVSLLCG 262
Query: 531 FSSSHPKEVQFFWEKNGRLL----GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWT 586
S+ P + W ++G +L + L + ++P + G Y+C N+ GQ ++
Sbjct: 263 ADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD-NRTVG 319
Query: 587 LEVLYAPRRLRVSMSPGDQV-MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLR 645
L V+YAP + V+ G V +EG++ ++ C + +NP + + S + +L+
Sbjct: 320 LSVMYAPWKPTVN---GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ 376
Query: 646 LE--PVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
LE V + G YWC N G+ R+ L+V ++P
Sbjct: 377 LELPAVSPEDDGEYWCVAENQYGQ-RATAFNLSVEFAP 413
Score = 40.0 bits (92), Expect = 0.009
Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 8/118 (6%)
Query: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNN--QSLPYHSQK 643
+++V Y P + V M+ + +EG +L C +D+NPP TW + S
Sbjct: 233 SMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPP-PLLTWMRDGTVLREAVAESLL 289
Query: 644 LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVY--YSPETIGRRVAVGLGSCLAIL 699
L LE V G Y C N+ G+ + +Y + P G VAV G ++IL
Sbjct: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE-GETVSIL 346
>gi|18104957 myelin associated glycoprotein isoform b precursor
[Homo sapiens]
Length = 582
Score = 115 bits (288), Expect = 2e-25
Identities = 130/465 (27%), Positives = 198/465 (42%), Gaps = 38/465 (8%)
Query: 16 LAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFIL----FHNPEYNKNTSKF 71
++ S W P ++ A+EG CV IPC + D +L ++ + N Y KN
Sbjct: 14 ISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPD-ELRPAVVHGVWYFNSPYPKNYPPV 72
Query: 72 DGTRLYESTKDGKVPSEQKRVQFLGDKN-KNCTLSIHPVHLNDSGQLGLRMESKTEKWME 130
+++S S Q R + LGD +NCTL + V G+ R +
Sbjct: 73 ----VFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYT 128
Query: 131 RIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWL-LEGVPMRQAAVT 189
+V + P+I +PPE+ EV ++C++ +C +L WL EG + + AV
Sbjct: 129 FSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEG--LGEPAVL 186
Query: 190 STSLTIKSVFTR-SELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
+ + + S L F P +G + CQ + ++VK+ P +
Sbjct: 187 GRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMN 246
Query: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK--QNTFTLNLREVTKDQSGK 306
+ +AI EG V++ C S+ P T W++DGT L++ + L L EVT + G
Sbjct: 247 SSVEAI--EGSHVSLLCGADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGV 302
Query: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLP--TNY 364
Y C N G + V L V YAP TV AVEG V LC + +NP P T +
Sbjct: 303 YACLAENAYGQD-NRTVGLSVMYAPWKPTVNGT-MVAVEGETVSILCSTQSNPDPILTIF 360
Query: 365 TWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTT 424
+ +E ++ +P + P G Y CVAEN GQR L V++ P
Sbjct: 361 KEKQILSTVIYESELQLELPAVSPEDDGEYWCVAEN--QYGQRATAFNLSVEFAP----V 414
Query: 425 VIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGV 469
++ DTV C SNP +P A+E PS V
Sbjct: 415 LLLESHCAAARDTVQCLC-VVKSNP-------EPSVAFELPSRNV 451
Score = 68.2 bits (165), Expect = 3e-11
Identities = 90/324 (27%), Positives = 136/324 (41%), Gaps = 34/324 (10%)
Query: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP-AVEGSQVEF 351
TL L V+ + GKY + D+G G ++ F + +T I+ P V G++VE
Sbjct: 101 TLLLSNVSPELGGKYYFR--GDLG-GYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEV 157
Query: 352 LCMSLAN--PLPTNYTWY-HNG---KEMQGRTEEK---------VHIPKILPWHAGTYSC 396
CM N L +W H G + GR E +H + C
Sbjct: 158 SCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGC 217
Query: 397 VAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW 456
A T Q A +DV+YPP V + + + EG V+L C +S+ P + W
Sbjct: 218 QASFPNTTLQFEGYASMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPPPLLT--W 273
Query: 457 KPHGAWEEPSLG---VLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
G ++ +L+++ V ++ AC A N++ V L+V YAP V
Sbjct: 274 MRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNG 333
Query: 513 IKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---NGRLLGKESQLNFDSISPEDAGSY 569
E G +VS+ C S+ + F EK + + E QL ++SPED G Y
Sbjct: 334 TMVAVE---GETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEY 390
Query: 570 SCWVNNSIGQTASKAWTLEVLYAP 593
C N GQ A+ A+ L V +AP
Sbjct: 391 WCVAENQYGQRAT-AFNLSVEFAP 413
Score = 65.5 bits (158), Expect = 2e-10
Identities = 68/278 (24%), Positives = 119/278 (42%), Gaps = 35/278 (12%)
Query: 429 PMPIREGDTVTLSCNYNSSNPSVT-RYEWKPHGAWEEPS-LGVLKIQNVGWDNTTI---- 482
P + G V +SC + P + W H EP+ LG L+ W ++
Sbjct: 146 PPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFV 205
Query: 483 ----------ACAAC--NSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCD 530
C A N+ + +++V+Y P V + E G+ VSL C
Sbjct: 206 PTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIE---GSHVSLLCG 262
Query: 531 FSSSHPKEVQFFWEKNGRLL----GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWT 586
S+ P + W ++G +L + L + ++P + G Y+C N+ GQ ++
Sbjct: 263 ADSNPPPLLT--WMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQD-NRTVG 319
Query: 587 LEVLYAPRRLRVSMSPGDQV-MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLR 645
L V+YAP + V+ G V +EG++ ++ C + +NP + + S + +L+
Sbjct: 320 LSVMYAPWKPTVN---GTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQ 376
Query: 646 LE--PVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
LE V + G YWC N G+ R+ L+V ++P
Sbjct: 377 LELPAVSPEDDGEYWCVAENQYGQ-RATAFNLSVEFAP 413
Score = 40.0 bits (92), Expect = 0.009
Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 8/118 (6%)
Query: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNN--QSLPYHSQK 643
+++V Y P + V M+ + +EG +L C +D+NPP TW + S
Sbjct: 233 SMDVKYPP--VIVEMNSSVEAIEGSHVSLLCGADSNPP-PLLTWMRDGTVLREAVAESLL 289
Query: 644 LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVY--YSPETIGRRVAVGLGSCLAIL 699
L LE V G Y C N+ G+ + +Y + P G VAV G ++IL
Sbjct: 290 LELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVE-GETVSIL 346
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 109 bits (272), Expect = 1e-23
Identities = 140/557 (25%), Positives = 225/557 (40%), Gaps = 70/557 (12%)
Query: 151 IQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQW 210
+ E QEV L C + P + WL +G P+ Q ++ L
Sbjct: 2038 VLEGQEVRLDCEADGQP---PPDVAWLKDGSPLGQ----DMGPHLRFYLDGGSLVLKGLR 2090
Query: 211 SHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV-REGDSVTMTCEVSS 269
+ TC + G+ TV NV P ++ S +V R G+ VTM C V
Sbjct: 2091 ASDAGAYTCVAHNPAGEDARLHTV--NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRG 2148
Query: 270 SNPEYTTVSWLKDGTSLK-KQNTF------TLNLREVTKDQSGKYCCQVSNDVGPGRSEE 322
S P + VSWLKDG L Q T TL + +V +G + C ++ G
Sbjct: 2149 SPPIH--VSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVA-DRN 2205
Query: 323 VFLQVQYAPEPSTVQILHSPAV-EGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK- 380
LQVQ P V+ + V GS VE C + PLP +W +G+ + ++ E+
Sbjct: 2206 FTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPL-VSWMKDGEPLLSQSLEQG 2264
Query: 381 --VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTV 438
+ + + +GTYSCVA + G +R +L V PP + + + G +
Sbjct: 2265 PSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLTVMEPPHIEDSGQPTELSLTPGAPM 2322
Query: 439 TLSCNYNSS-NPSVTRYEWKPHGAW------EEPSLGVLKIQNVGWDNTTIACAACNSWC 491
L C+ + P++T W G + VL++++ G C A +
Sbjct: 2323 ELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVLRVRDAG----LYTCLAESPAG 2375
Query: 492 SWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG 551
+ + VQ P V R + + + G V L+C + ++ W ++G +L
Sbjct: 2376 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKIT--WHRDGIVLQ 2432
Query: 552 KESQLNF---------DSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSP 602
+++ F ++S D+G YSC N+ G T S A+ +E+ P +R S P
Sbjct: 2433 EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPT-IR-SGPP 2489
Query: 603 GDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQK----------LRLEPVKVQ 652
V ++A L C++D P W +P + LR++PV Q
Sbjct: 2490 AVNVSVNQTALLPCQADGVPA----PLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ 2545
Query: 653 HSGAYWCQGTNSVGKGR 669
+G Y C +NS G R
Sbjct: 2546 DAGHYLCLASNSAGSDR 2562
Score = 95.1 bits (235), Expect = 2e-19
Identities = 155/657 (23%), Positives = 252/657 (38%), Gaps = 98/657 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG+ + V DK L + + D+G ++ + + +LNV P
Sbjct: 915 KDGRPLEPRPGVHLSADK---ALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAP 971
Query: 141 -FPPHIQLPPEIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSV 198
FP ++E +L+C C G P ++ W +G P+ L S
Sbjct: 972 VFPLRESHTLTVREGHPTSLSC----ECRGVPFPKISWRKDGQPLPGEGA---GLQHVSA 1024
Query: 199 FTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLE-IKVTPSDAIVRE 257
R Q + G TC+ + G S+ +QL V P++ + P+ V +
Sbjct: 1025 VGRLLYLGQAQLAQEGTY-TCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVVQ 1081
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGT------SLKKQNTF-TLNLREVTKDQSGKYCCQ 310
T+ C + P TV+W +DG L+ QN +L++ +G+Y C
Sbjct: 1082 DGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCV 1139
Query: 311 VSNDVGPGRSEEVF-LQVQYAPE--------PSTVQILHSPAVEGSQVEFLCMSLANPLP 361
N G R+E F L V PE + LHSP + LC ++ P P
Sbjct: 1140 AENLAG--RAERKFELSVLVPPELIGDLDPLTNITAALHSP------LTLLCEAMGIPPP 1191
Query: 362 TNYTWYHNGKEMQGRTEEK--------VHIPKILPWHAGTYSCVAENILGTGQRGPGAEL 413
W+ G+E E+ + + + +G YSC+A N G +R E+
Sbjct: 1192 A-IRWFR-GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1249
Query: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSS-NPSVTRY-EWKPHGAWE----EPSL 467
V PP ++ + + +G T L CN P +T + + +P + P
Sbjct: 1250 LV--PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDG 1307
Query: 468 GVLKIQNVGWDNTT-IACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--GNS 524
+L++ + +C A N+ L+V AP + + E+ N
Sbjct: 1308 VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP 1367
Query: 525 VSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSISPEDAGSYSCWVNN 575
+SL C+ + + W K+G +LL L + EDAG Y+C V N
Sbjct: 1368 ISLICEALAFPSPNIT--WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1425
Query: 576 SIGQTASKAWTLEVLYAPRRLRVSMSPGDQVME----------GKSATLTCESDANPPVS 625
+G+ A K + +EVL P S+S D + E + TL CES A PP +
Sbjct: 1426 ELGE-AVKNYHVEVLIPP-----SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT 1479
Query: 626 HYTWFDWNNQSLPY-------HSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTL 675
W+ P + L+++P +V SG Y C TN G+ + L
Sbjct: 1480 -IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVL 1535
Score = 86.3 bits (212), Expect = 1e-16
Identities = 151/624 (24%), Positives = 236/624 (37%), Gaps = 102/624 (16%)
Query: 139 RPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVP------MRQAAVTSTS 192
R F + PP I S E ++ + +QL GVP + A+ TS
Sbjct: 300 RDFQLRVHAPPTIWGSNETGEVAVME----DHLVQLLCEARGVPTPNITWFKDGALLPTS 355
Query: 193 LTIKSVFTRS--ELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLE-IKVT 249
K V+TR +L+ S + TC+ +A G + +L+V P +E
Sbjct: 356 T--KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA--AEKATRLDVYVPPTIEGAGGR 411
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKD 302
P G V + C V+ +P T+SW +G + + N L L +
Sbjct: 412 PYVVKAVAGRPVALEC-VARGHPS-PTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA 469
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHS-PAVEGSQVEFLCMSLANPLP 361
SG Y C S+ G + ++VQ P+ + L + G +E C + +P+P
Sbjct: 470 SSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP 528
Query: 362 TNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAENILGTGQRGPGAELD 414
T W NG+ + +V HI + H+G ++C A N GT GAE++
Sbjct: 529 T-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA----GAEVE 583
Query: 415 VQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-------------KPHGA 461
V + V++ P+ S + +P V R W P
Sbjct: 584 VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR-GWGAHPKPPLVEGWCSPGSL 642
Query: 462 WEEPSLGV---------LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511
W EP+ G+ L+I+ V D CAA N VAL V P +
Sbjct: 643 WGEPT-GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIE 698
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFF--------W-----EKNGRLLG-KESQLN 557
+ SV+L+C S P +V +F W +GR+L +++QL+
Sbjct: 699 PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLS 758
Query: 558 FDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCE 617
DAGSY C +N G T + + L V PR PG V+ LTC
Sbjct: 759 -------DAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPG-PVLVNTPVRLTCN 809
Query: 618 SDANPPVSHYTWFDWNNQSLPYHSQKLRLEP---------VKVQHSGAYWCQGTNSVGKG 668
+ P + W N P + L++ P + SG Y C ++VG+
Sbjct: 810 ATGAPSPT-LMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868
Query: 669 RSPLSTLTVYYSPETIGRRVAVGL 692
R + L V+ P +G + V +
Sbjct: 869 RQDV-VLQVHMPPSILGEELNVSV 891
Score = 84.7 bits (208), Expect = 3e-16
Identities = 110/469 (23%), Positives = 191/469 (40%), Gaps = 50/469 (10%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK-------QNTFTLNLREVTKDQS 304
+ V +V++ C + NP T+SWL++G ++ L + +
Sbjct: 1663 EVTVNASSTVSLQCP-ALGNP-VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADA 1720
Query: 305 GKYCCQVSNDVGPGRSEEVF-LQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTN 363
Y C N G +E++F L+VQ P + + + A+ S V C A+P P
Sbjct: 1721 ASYMCVAENQAGS--AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNP-E 1777
Query: 364 YTWYHNGKEMQGRTE-------EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQ 416
TWY + + + E + + + +G Y+C A N G Q+ +L V
Sbjct: 1778 VTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL--VQLSVL 1835
Query: 417 YPP--KKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKPHGAWEEPSLGV---- 469
PP ++ Q+ + +R GD LSC ++ P+VT Y+ + + +
Sbjct: 1836 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1895
Query: 470 -LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSL 527
L+IQ D +C N L VQ P K + +S++ +G+ + L
Sbjct: 1896 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPT-FENPKTETVSQV-AGSPLVL 1953
Query: 528 QCDFSSSHPKEVQFFWEKNG-------RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQT 580
CD S V + ++ ++ + +L + P AG+Y+C N+ +
Sbjct: 1954 TCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE- 2012
Query: 581 ASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWN--NQSLP 638
A K + + VL APR ++ V+EG+ L CE+D PP D + Q +
Sbjct: 2013 ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 2072
Query: 639 YHSQ------KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
H + L L+ ++ +GAY C N G+ + L T+ V P
Sbjct: 2073 PHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED-ARLHTVNVLVPP 2120
Score = 79.3 bits (194), Expect = 1e-14
Identities = 112/443 (25%), Positives = 174/443 (39%), Gaps = 78/443 (17%)
Query: 277 VSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVGP---GRSEEVFLQ 326
VSW KD L ++ +L ++ V +G Y C SN G GR V
Sbjct: 2513 VSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEP 2572
Query: 327 VQYAPEPSTVQIL-HSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPK 385
AP PS + + H+PA+ C + +P P W+ +G+++ R ++ + +
Sbjct: 2573 PAIAPSPSNLTLTAHTPAL------LPCEASGSPKPL-VVWWKDGQKLDFRLQQGAY--R 2623
Query: 386 ILPWHA-----------GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIRE 434
+LP +A + CV N +G R ++ V PP Q +
Sbjct: 2624 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRL--YQVTVHVPPTIADD--QTDFTVTM 2679
Query: 435 GDTVTLSCNYNSSNPSVTRYEWKPHGA--------WEEPSLGVLKI-QNVGWDNTTIACA 485
V L+C +++ P+ T W GA + G L+I Q + C+
Sbjct: 2680 MAPVVLTC-HSTGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2737
Query: 486 ACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSG---NSVSLQCDFSSSHPKEVQFF 542
A NS V L VQ +P +KPL + V L C+ +S P+
Sbjct: 2738 ARNSAGVAHKHVFLTVQASP------VVKPLPSVVRAVAEEEVLLPCE-ASGIPRPT-IT 2789
Query: 543 WEKNGRLLGKE--------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPR 594
W+K G + QL SPEDAG+Y C NS G K T V+ P
Sbjct: 2790 WQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK--TRLVVQVPP 2847
Query: 595 RLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEP------ 648
+ + P EG A L C++ +P + TW D + Q + K ++P
Sbjct: 2848 VIENGL-PDLSTTEGSHAFLPCKARGSPE-PNITW-DKDGQPVSGAEGKFTIQPSGELLV 2904
Query: 649 --VKVQHSGAYWCQGTNSVGKGR 669
++ Q +G Y C N+VG+ R
Sbjct: 2905 KNLEGQDAGTYTCTAENAVGRAR 2927
Score = 77.0 bits (188), Expect = 7e-14
Identities = 119/451 (26%), Positives = 175/451 (38%), Gaps = 74/451 (16%)
Query: 261 VTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSN 313
V +TC S+ TVSW K G L + + L + + +G+Y C N
Sbjct: 2683 VVLTCH--STGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN 2740
Query: 314 DVGPGRSEEVFLQVQYAPE----PSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHN 369
G + VFL VQ +P PS V+ AV +V C + P PT TW
Sbjct: 2741 SAGVAH-KHVFLTVQASPVVKPLPSVVR-----AVAEEEVLLPCEASGIPRPT-ITWQKE 2793
Query: 370 GKEMQGRTEEKV------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVT 423
G + +V I P AG Y C+A+N G+ L VQ PP
Sbjct: 2794 GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK--TRLVVQVPP---- 2847
Query: 424 TVIQNPMP---IREGDTVTLSCNYNSS-NPSVT-RYEWKPHGAWE-----EPSLGVLKIQ 473
VI+N +P EG L C S P++T + +P E +PS G L ++
Sbjct: 2848 -VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPS-GELLVK 2905
Query: 474 NV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFS 532
N+ G D T C A N+ V L + P + + L G+ + L+C
Sbjct: 2906 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---RLGDRLWLRCAAR 2962
Query: 533 SSHPKEVQFFWEKNGRLLGKE-------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAW 585
S + W N R + + S L ++S ED+G+Y CW N +G+T + ++
Sbjct: 2963 GSPTPRIG--WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF 3020
Query: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYTWFDWNNQSLPYHSQKL 644
+ V AP + S + + G S L C +P P H W LP L
Sbjct: 3021 -VHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVRGDPVPDIH-----WIKDGLPLRGSHL 3073
Query: 645 R---------LEPVKVQHSGAYWCQGTNSVG 666
R + + +G Y C N +G
Sbjct: 3074 RHQLQNGSLTIHRTERDDAGRYQCLAENEMG 3104
Score = 73.2 bits (178), Expect = 1e-12
Identities = 107/436 (24%), Positives = 169/436 (38%), Gaps = 65/436 (14%)
Query: 294 LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP--EPSTVQILHSPAVEGSQVEF 351
L + +V G Y C +N G + EV L+V P EP V + +E + V
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESK-REVALKVLVPPNIEPGPV---NKAVLENASVTL 714
Query: 352 LCMSLANPLPTNYTWYHNGK----------EMQGRTEEKVHIPKILPWHAGTYSCVAENI 401
C++ P P + +W+ + + GR + I + AG+Y CVA N+
Sbjct: 715 ECLASGVP-PPDVSWFKGHQPVSSWMGVTVSVDGRV---LRIEQAQLSDAGSYRCVASNV 770
Query: 402 LGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGA 461
G+ + G ++V P ++T P P+ V L+CN + PS T W G
Sbjct: 771 AGSTELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGA-PSPT-LMWLKDGN 825
Query: 462 WEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS--- 517
P+ G +Q G T+A A + ++ V +DV ++ P S
Sbjct: 826 PVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 884
Query: 518 -----EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR---------LLGKESQLNFDSISP 563
+ + SV+L+C + P + W K+GR L ++ L D
Sbjct: 885 EELNVSVVANESVALECQSHAMPPPVLS--WWKDGRPLEPRPGVHLSADKALLQVDRADV 942
Query: 564 EDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
DAG Y+C N G+ + K + L V AP + S V EG +L+CE P
Sbjct: 943 WDAGHYTCEALNQAGR-SEKHYNLNVWVAP-VFPLRESHTLTVREGHPTSLSCECRGVP- 999
Query: 624 VSHYTWFDWNNQSLPYHSQKLRLEPV------------KVQHSGAYWCQGTNSVGKGRSP 671
+ W P + L+ V ++ G Y C+ +N VG
Sbjct: 1000 ---FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 1056
Query: 672 LSTLTVYYSPETIGRR 687
L L V+ P+ G R
Sbjct: 1057 LQ-LEVHVPPQIAGPR 1071
Score = 69.3 bits (168), Expect = 1e-11
Identities = 127/557 (22%), Positives = 203/557 (36%), Gaps = 98/557 (17%)
Query: 204 LKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTM 263
LK + + +C + G+ N +V++ V P +E + V +G + +
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP--PSIENEDLEEVIKVLDGQTAHL 1274
Query: 264 TCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVG 316
C V+ +P+ ++W KDG L + + L + + +G Y C +N VG
Sbjct: 1275 MCNVTG-HPQ-PKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVG 1332
Query: 317 PGRSEEVFLQVQYAP-----------EPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
+++ L V AP E TV + + + +C +LA P P N T
Sbjct: 1333 E-KTKHFQLSVLLAPTILGGAEDSADEEVTVTV-------NNPISLICEALAFPSP-NIT 1383
Query: 366 WYHNGKEMQGRTEEKV----HIPKILPWH---AGTYSCVAENILGTGQRGPGAELDVQYP 418
W +G + ++ H +IL AG Y+CV N LG + ++V P
Sbjct: 1384 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN--YHVEVLIP 1441
Query: 419 PKKVTTVIQNPMPIRE-----GDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPS-----LG 468
P + ++E T+TL C + P R W G PS LG
Sbjct: 1442 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLG 1499
Query: 469 ---VLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--- 521
+L+IQ D+ C A N + +Q P +V EI S
Sbjct: 1500 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1559
Query: 522 --------------GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDS 560
N L CD ++ P ++ ++ E G E L
Sbjct: 1560 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL 1619
Query: 561 ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT--LTCES 618
+ E+AG YSC +N +G+ + L VL P L + ++V S+T L C +
Sbjct: 1620 VRAENAGRYSCKASNEVGEDWLH-YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPA 1678
Query: 619 DANPPVSHYTWFDWNNQSLPY----------HSQKLRLEPVKVQHSGAYWCQGTNSVGKG 668
NP + W LP+ Q L++ +V + +Y C N G
Sbjct: 1679 LGNPVPT----ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1734
Query: 669 RSPLSTLTVYYSPETIG 685
L TL V P G
Sbjct: 1735 EK-LFTLRVQVPPRIAG 1750
Score = 67.8 bits (164), Expect = 4e-11
Identities = 142/655 (21%), Positives = 243/655 (37%), Gaps = 92/655 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG + +Q L + L I D+GQ + ++ + ++ H+ V
Sbjct: 1386 KDGAPFEASRNIQLLPGTHG---LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--- 1439
Query: 141 FPPHIQLPPEIQE----SQEVTLTCLLNFSCYGY---PIQLQWLLEGVPMRQAAVTSTSL 193
PP I + E + + L C + P ++W +G P+ + S
Sbjct: 1440 IPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV------TPSS 1493
Query: 194 TIKSVFTRSELKFSP-QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD 252
++ + L+ P Q S G+ + C + G+ + V + V P + KV
Sbjct: 1494 RLQVLGEGRLLQIQPTQVSDSGRYL-CVATNVAGEDDQDFNVLIQV---PPMFQKVGDFS 1549
Query: 253 A----IVREGDS---VTMTCEVSSSNPEYT----------TVSWLKDGTSLKK------- 288
A + RE ++ VT E+ +NP Y ++W ++ L
Sbjct: 1550 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVL 1609
Query: 289 QNTFTLNLREVTKDQSGKYCCQVSNDVGPG-RSEEVFLQVQYAPEPSTVQILHSPAVEGS 347
Q L + V + +G+Y C+ SN+VG E+ + T +++ V S
Sbjct: 1610 QGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 1669
Query: 348 Q-VEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAE 399
V C +L NP+PT +W NG +V + A +Y CVAE
Sbjct: 1670 STVSLQCPALGNPVPT-ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1728
Query: 400 NILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKP 458
N G+ ++ L VQ PP+ ++ I +V+L C+ ++ NP VT Y+
Sbjct: 1729 NQAGSAEK--LFTLRVQVPPRIAGLDLEQVTAIL-NSSVSLPCDVHAHPNPEVTWYKDSQ 1785
Query: 459 HGAWEE-----PSLGVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRV-R 511
+ E P L++ D+ C A N+ V L+V P + R
Sbjct: 1786 ALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPR 1845
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDSISPE 564
+ + G+ L C+ + V ++ + +L + +Q L
Sbjct: 1846 GPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVS 1905
Query: 565 DAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPV 624
D G YSC V+N G+ A + +TL V P QV G LTC+ P
Sbjct: 1906 DKGLYSCKVSNVAGE-AVRTFTLTVQVPPTFENPKTETVSQV-AGSPLVLTCDVSGVPAP 1963
Query: 625 SHYTWFDWNNQSLPYHSQ----------KLRLEPVKVQHSGAYWCQGTNSVGKGR 669
+ W +P S +L+L ++ +G Y C N+ + R
Sbjct: 1964 T----VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR 2014
Score = 55.8 bits (133), Expect = 2e-07
Identities = 48/185 (25%), Positives = 81/185 (43%), Gaps = 26/185 (14%)
Query: 236 LNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN----- 290
++VK P L+ + S + G S+ + C V + W+KDG L+ +
Sbjct: 3021 VHVKEAPVLQGEAF-SYLVEPVGGSIQLDCVVRGD--PVPDIHWIKDGLPLRGSHLRHQL 3077
Query: 291 -TFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP----EPSTVQILHSPAVE 345
+L + +D +G+Y C N++G + + V L +Q AP EP + +
Sbjct: 3078 QNGSLTIHRTERDDAGRYQCLAENEMGVAK-KVVILVLQSAPVFQVEPQDMTVR-----S 3131
Query: 346 GSQVEFLCMSLANPLPTNYTWYHNGKEMQG----RT--EEKVHIPKILPWHAGTYSCVAE 399
G V C + P PT W G+ ++ RT + + + + AGTY CVA
Sbjct: 3132 GDDVALRCQATGEPTPT-IEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAH 3190
Query: 400 NILGT 404
N+LG+
Sbjct: 3191 NLLGS 3195
Score = 50.8 bits (120), Expect = 5e-06
Identities = 85/375 (22%), Positives = 142/375 (37%), Gaps = 69/375 (18%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK-KQNTFTLN------LREVTKDQS 304
D EG + C+ S PE ++W KDG + + FT+ ++ + +
Sbjct: 2855 DLSTTEGSHAFLPCKARGS-PE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2912
Query: 305 GKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNY 364
G Y C N VG R V L + P +T+ S + G ++ C + +P P
Sbjct: 2913 GTYTCTAENAVGRAR-RRVHLTILVLPVFTTLPGDRSLRL-GDRLWLRCAARGSPTP-RI 2969
Query: 365 TWYHNGKEMQGRTEEK-----VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPP 419
W N + + E+ + + +GTY C AEN +G Q V +
Sbjct: 2970 GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA-------VSFVH 3022
Query: 420 KKVTTVIQNPM------PIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSL------ 467
K V+Q P+ G ++ L C V R + P W + L
Sbjct: 3023 VKEAPVLQGEAFSYLVEPV--GGSIQLDC--------VVRGDPVPDIHWIKDGLPLRGSH 3072
Query: 468 -------GVLKIQNVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS-E 518
G L I D+ C A N V L +Q AP V +++P
Sbjct: 3073 LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP----VFQVEPQDMT 3128
Query: 519 IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLN--------FDSISPEDAGSYS 570
+ SG+ V+L+C + ++ W + G+ L +L +++ DAG+Y
Sbjct: 3129 VRSGDDVALRCQATGEPTPTIE--WLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 3186
Query: 571 CWVNNSIGQTASKAW 585
C +N +G ++A+
Sbjct: 3187 CVAHNLLGSATARAF 3201
Score = 49.7 bits (117), Expect = 1e-05
Identities = 81/358 (22%), Positives = 131/358 (36%), Gaps = 50/358 (13%)
Query: 346 GSQVEFLCMSLANPLPTNYTWYHN-------GKEMQGRTEEKVHIPKILPWHAGT---YS 395
G+ VE C + P P W + G +Q +E + +I H G Y
Sbjct: 232 GADVELQCWTSGVPTP-QVEWTKDRQPVLPGGPHLQ--VQEDGQVLRITGSHVGDEGRYQ 288
Query: 396 CVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRY 454
CVA + GQ+ +L V PP + + + E V L C P++T
Sbjct: 289 CVAFS--PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT-- 344
Query: 455 EWKPHGAWEEPSLGVLKIQN---------VGWDNTTIACAACNSWCSWASPVALNVQYAP 505
W GA S V+ + D C A N+ + L+V Y P
Sbjct: 345 -WFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVP 402
Query: 506 RDVRVRKIKP-LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQ 555
+ +P + + +G V+L+C + HP W G RL S
Sbjct: 403 PTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSPT-LSWHHEGLPVAESNESRLETDGSV 460
Query: 556 LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLT 615
L +S +G YSC ++ G+ + +++EV P+ L + G+ L
Sbjct: 461 LRLESPGEASSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQPLELP 519
Query: 616 CESDANPPVSHYTWFDWNNQS-------LPYHSQKLRLEPVKVQHSGAYWCQGTNSVG 666
C++ +P V W + + L ++ V++ HSG + CQ TN G
Sbjct: 520 CQASGSP-VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Score = 46.6 bits (109), Expect = 1e-04
Identities = 55/202 (27%), Positives = 83/202 (41%), Gaps = 33/202 (16%)
Query: 509 RVRKIKPLSEIHSGNSVSLQCDFSSSH--PKEVQFFWEKN----------GRLLGKESQL 556
RV +IK L ++ +V L+ +H PK Q W K G + +E L
Sbjct: 3 RVLEIKGLGDV--ALTVGLEAGGCGTHGTPKP-QVTWRKGPSSEPLHGQPGVAVLEEGSL 59
Query: 557 NFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLT 615
S+SP D+G Y C N +G T+ +A V+Y P +R + M G+S TL
Sbjct: 60 FLASVSPADSGDYECQATNEVGSTSRRAKL--VVYVPPSIREDGRKANVSGMAGQSLTLE 117
Query: 616 CESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTL 675
C+++ PV W + +L V + +G W G VG R
Sbjct: 118 CDANGF-PVPEIVWL-----------KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 165
Query: 676 TVYY---SPETIGRRVAVGLGS 694
++++ P GRR A GS
Sbjct: 166 SLHFPRIQPGRSGRRGAQAGGS 187
Score = 43.5 bits (101), Expect = 8e-04
Identities = 130/610 (21%), Positives = 208/610 (34%), Gaps = 88/610 (14%)
Query: 103 TLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCL 162
+L + V DSG S+ + L V E PPHI+ + + E++LT
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME---PPHIE---DSGQPTELSLTP- 2318
Query: 163 LNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQ 222
G P++L +G P + + S + G + TC +
Sbjct: 2319 ------GAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAG-LYTCLAE 2371
Query: 223 DADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKD 282
G + ++ V+ P + P + + + C V + ++W +D
Sbjct: 2372 SPAGAI--EKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP--KITWHRD 2427
Query: 283 GTSLKK-------QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPST 335
G L++ + L L+ ++ SG Y C N G V + E T
Sbjct: 2428 GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS-------TSVAFRVEIHT 2480
Query: 336 VQILHS--PAVEGS--QVEFL-CMSLANPLPTNYTWYHNGKEMQGRT-------EEKVHI 383
V + S PAV S Q L C + P P +W + + R+ E + I
Sbjct: 2481 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPL-VSWRKDRVPLDPRSPRFEILPEGSLRI 2539
Query: 384 PKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCN 443
+L AG Y C+A N G+ ++ G +L V PP + + + + L C
Sbjct: 2540 QPVLAQDAGHYLCLASNSAGSDRQ--GRDLRVLEPPAIAPS--PSNLTLTAHTPALLPCE 2595
Query: 444 YNSSNPSVTRYEWK---------PHGAWE-EPSLGVLKIQNVGWDNTTIACAACNSWCSW 493
S +P WK GA+ PS +L D+ C N
Sbjct: 2596 -ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEA 2654
Query: 494 ASPVALNVQYAP------RDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG 547
+ V P D V + P+ + + +S + S Q +G
Sbjct: 2655 HRLYQVTVHVPPTIADDQTDFTVTMMAPV--VLTCHSTGIPAPTVSWSKAGAQLGARGSG 2712
Query: 548 RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVM 607
+ L P AG Y+C NS G A K L V +P + P V+
Sbjct: 2713 YRVSPSGALEIGQALPIHAGRYTCSARNSAG-VAHKHVFLTVQASP-----VVKPLPSVV 2766
Query: 608 EG---KSATLTCESDANPPVSHYTW--------FDWNNQSLPYHSQKLRLEPVKVQHSGA 656
+ L CE+ P + TW + Q LP +LR+ + +G
Sbjct: 2767 RAVAEEEVLLPCEASGIPRPT-ITWQKEGLNVATGVSTQVLP--GGQLRIAHASPEDAGN 2823
Query: 657 YWCQGTNSVG 666
Y C NS G
Sbjct: 2824 YLCIAKNSAG 2833
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 109 bits (272), Expect = 1e-23
Identities = 140/557 (25%), Positives = 225/557 (40%), Gaps = 70/557 (12%)
Query: 151 IQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQW 210
+ E QEV L C + P + WL +G P+ Q ++ L
Sbjct: 3229 VLEGQEVRLDCEADGQP---PPDVAWLKDGSPLGQ----DMGPHLRFYLDGGSLVLKGLR 3281
Query: 211 SHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV-REGDSVTMTCEVSS 269
+ TC + G+ TV NV P ++ S +V R G+ VTM C V
Sbjct: 3282 ASDAGAYTCVAHNPAGEDARLHTV--NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRG 3339
Query: 270 SNPEYTTVSWLKDGTSLK-KQNTF------TLNLREVTKDQSGKYCCQVSNDVGPGRSEE 322
S P + VSWLKDG L Q T TL + +V +G + C ++ G
Sbjct: 3340 SPPIH--VSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVA-DRN 3396
Query: 323 VFLQVQYAPEPSTVQILHSPAV-EGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK- 380
LQVQ P V+ + V GS VE C + PLP +W +G+ + ++ E+
Sbjct: 3397 FTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPL-VSWMKDGEPLLSQSLEQG 3455
Query: 381 --VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTV 438
+ + + +GTYSCVA + G +R +L V PP + + + G +
Sbjct: 3456 PSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLTVMEPPHIEDSGQPTELSLTPGAPM 3513
Query: 439 TLSCNYNSS-NPSVTRYEWKPHGAW------EEPSLGVLKIQNVGWDNTTIACAACNSWC 491
L C+ + P++T W G + VL++++ G C A +
Sbjct: 3514 ELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVLRVRDAG----LYTCLAESPAG 3566
Query: 492 SWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG 551
+ + VQ P V R + + + G V L+C + ++ W ++G +L
Sbjct: 3567 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKIT--WHRDGIVLQ 3623
Query: 552 KESQLNF---------DSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSP 602
+++ F ++S D+G YSC N+ G T S A+ +E+ P +R S P
Sbjct: 3624 EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPT-IR-SGPP 3680
Query: 603 GDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQK----------LRLEPVKVQ 652
V ++A L C++D P W +P + LR++PV Q
Sbjct: 3681 AVNVSVNQTALLPCQADGVPA----PLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ 3736
Query: 653 HSGAYWCQGTNSVGKGR 669
+G Y C +NS G R
Sbjct: 3737 DAGHYLCLASNSAGSDR 3753
Score = 97.4 bits (241), Expect = 5e-20
Identities = 111/462 (24%), Positives = 186/462 (40%), Gaps = 63/462 (13%)
Query: 248 VTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN-------TFTLNLREVT 300
V + V G++ ++C V P T W++D L +L + +
Sbjct: 521 VPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGII 578
Query: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL 360
G+Y C SN G R+ V+L V+ AP+ S + +G +V+ C + P
Sbjct: 579 PTDGGRYQCVASNANGVTRAS-VWLLVREAPQVS-IHTSSQHFSQGVEVKVSCSASGYPT 636
Query: 361 PTNYTWYHNGKEMQGRTEEKVHIPK--------ILPWHAGTYSCVAENILGTGQRGPGAE 412
P + +W + +Q + ++H+ + P AG YSC A N +GT Q
Sbjct: 637 P-HISWSRESQALQ--EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE----T 689
Query: 413 LDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG-----AWEEPSL 467
+ + Y + + + + G+ L C + P R W G A E S
Sbjct: 690 VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSSS 747
Query: 468 GVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVS 526
G L+I D T C A N ++ + L V +AP+ + ++ + G S
Sbjct: 748 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ---LTELPRDVTVELGRSAL 804
Query: 527 LQCDFSSSHPKEVQFFWEK-NGRLLG--------------KESQLNFDSISPEDAGSYSC 571
L C + P V W + +G+ LG L F+S++PED Y C
Sbjct: 805 LACRATGRPPPTVT--WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 862
Query: 572 WVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFD 631
N G+ ++A + +AP ++ S +P +V+EG+ +L C A P+ W
Sbjct: 863 EARNVFGKVQAEARLIVTGHAPPQI-ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK 921
Query: 632 WNNQSLPYHSQ-------KLRLEPVKVQHSGAYWCQGTNSVG 666
+ + LP S+ L L+ +H+G Y C TN+ G
Sbjct: 922 -DGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962
Score = 94.0 bits (232), Expect = 5e-19
Identities = 155/657 (23%), Positives = 251/657 (38%), Gaps = 98/657 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG+ + V DK L + + D+G ++ + +LNV P
Sbjct: 2106 KDGRPLEPRPGVHLSADK---ALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 2162
Query: 141 -FPPHIQLPPEIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSV 198
FP ++E +L+C C G P ++ W +G P+ L S
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSC----ECRGVPFPKISWRKDGQPLPGEGA---GLQHVSA 2215
Query: 199 FTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLE-IKVTPSDAIVRE 257
R Q + G TC+ + G S+ +QL V P++ + P+ V +
Sbjct: 2216 VGRLLYLGQAQLAQEGTY-TCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVVQ 2272
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGT------SLKKQNTF-TLNLREVTKDQSGKYCCQ 310
T+ C + P TV+W +DG L+ QN +L++ +G+Y C
Sbjct: 2273 DGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCV 2330
Query: 311 VSNDVGPGRSEEVF-LQVQYAPE--------PSTVQILHSPAVEGSQVEFLCMSLANPLP 361
N G R+E F L V PE + LHSP + LC ++ P P
Sbjct: 2331 AENLAG--RAERKFELSVLVPPELIGDLDPLTNITAALHSP------LTLLCEAMGIPPP 2382
Query: 362 TNYTWYHNGKEMQGRTEEK--------VHIPKILPWHAGTYSCVAENILGTGQRGPGAEL 413
W+ G+E E+ + + + +G YSC+A N G +R E+
Sbjct: 2383 A-IRWFR-GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 2440
Query: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSS-NPSVTRY-EWKPHGAWE----EPSL 467
V PP ++ + + +G T L CN P +T + + +P + P
Sbjct: 2441 LV--PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDG 2498
Query: 468 GVLKIQNVGWDNTT-IACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--GNS 524
+L++ + +C A N+ L+V AP + + E+ N
Sbjct: 2499 VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP 2558
Query: 525 VSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSISPEDAGSYSCWVNN 575
+SL C+ + + W K+G +LL L + EDAG Y+C V N
Sbjct: 2559 ISLICEALAFPSPNIT--WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 2616
Query: 576 SIGQTASKAWTLEVLYAPRRLRVSMSPGDQVME----------GKSATLTCESDANPPVS 625
+G+ A K + +EVL P S+S D + E + TL CES A PP +
Sbjct: 2617 ELGE-AVKNYHVEVLIPP-----SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPT 2670
Query: 626 HYTWFDWNNQSLPY-------HSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTL 675
W+ P + L+++P +V SG Y C TN G+ + L
Sbjct: 2671 -IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVL 2726
Score = 86.3 bits (212), Expect = 1e-16
Identities = 151/624 (24%), Positives = 236/624 (37%), Gaps = 102/624 (16%)
Query: 139 RPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVP------MRQAAVTSTS 192
R F + PP I S E ++ + +QL GVP + A+ TS
Sbjct: 1491 RDFQLRVHAPPTIWGSNETGEVAVME----DHLVQLLCEARGVPTPNITWFKDGALLPTS 1546
Query: 193 LTIKSVFTRS--ELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLE-IKVT 249
K V+TR +L+ S + TC+ +A G + +L+V P +E
Sbjct: 1547 T--KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA--AEKATRLDVYVPPTIEGAGGR 1602
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKD 302
P G V + C V+ +P T+SW +G + + N L L +
Sbjct: 1603 PYVVKAVAGRPVALEC-VARGHPS-PTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA 1660
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHS-PAVEGSQVEFLCMSLANPLP 361
SG Y C S+ G + ++VQ P+ + L + G +E C + +P+P
Sbjct: 1661 SSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP 1719
Query: 362 TNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAENILGTGQRGPGAELD 414
T W NG+ + +V HI + H+G ++C A N GT GAE++
Sbjct: 1720 T-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA----GAEVE 1774
Query: 415 VQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-------------KPHGA 461
V + V++ P+ S + +P V R W P
Sbjct: 1775 VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR-GWGAHPKPPLVEGWCSPGSL 1833
Query: 462 WEEPSLGV---------LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511
W EP+ G+ L+I+ V D CAA N VAL V P +
Sbjct: 1834 WGEPT-GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIE 1889
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFF--------W-----EKNGRLLG-KESQLN 557
+ SV+L+C S P +V +F W +GR+L +++QL+
Sbjct: 1890 PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLS 1949
Query: 558 FDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCE 617
DAGSY C +N G T + + L V PR PG V+ LTC
Sbjct: 1950 -------DAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPG-PVLVNTPVRLTCN 2000
Query: 618 SDANPPVSHYTWFDWNNQSLPYHSQKLRLEP---------VKVQHSGAYWCQGTNSVGKG 668
+ P + W N P + L++ P + SG Y C ++VG+
Sbjct: 2001 ATGAPSPT-LMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059
Query: 669 RSPLSTLTVYYSPETIGRRVAVGL 692
R + L V+ P +G + V +
Sbjct: 2060 RQDV-VLQVHMPPSILGEELNVSV 2082
Score = 84.7 bits (208), Expect = 3e-16
Identities = 110/469 (23%), Positives = 191/469 (40%), Gaps = 50/469 (10%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK-------QNTFTLNLREVTKDQS 304
+ V +V++ C + NP T+SWL++G ++ L + +
Sbjct: 2854 EVTVNASSTVSLQCP-ALGNP-VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADA 2911
Query: 305 GKYCCQVSNDVGPGRSEEVF-LQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTN 363
Y C N G +E++F L+VQ P + + + A+ S V C A+P P
Sbjct: 2912 ASYMCVAENQAGS--AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNP-E 2968
Query: 364 YTWYHNGKEMQGRTE-------EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQ 416
TWY + + + E + + + +G Y+C A N G Q+ +L V
Sbjct: 2969 VTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL--VQLSVL 3026
Query: 417 YPP--KKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKPHGAWEEPSLGV---- 469
PP ++ Q+ + +R GD LSC ++ P+VT Y+ + + +
Sbjct: 3027 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 3086
Query: 470 -LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSL 527
L+IQ D +C N L VQ P K + +S++ +G+ + L
Sbjct: 3087 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPT-FENPKTETVSQV-AGSPLVL 3144
Query: 528 QCDFSSSHPKEVQFFWEKNG-------RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQT 580
CD S V + ++ ++ + +L + P AG+Y+C N+ +
Sbjct: 3145 TCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE- 3203
Query: 581 ASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWN--NQSLP 638
A K + + VL APR ++ V+EG+ L CE+D PP D + Q +
Sbjct: 3204 ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 3263
Query: 639 YHSQ------KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
H + L L+ ++ +GAY C N G+ + L T+ V P
Sbjct: 3264 PHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED-ARLHTVNVLVPP 3311
Score = 79.3 bits (194), Expect = 1e-14
Identities = 112/443 (25%), Positives = 174/443 (39%), Gaps = 78/443 (17%)
Query: 277 VSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVGP---GRSEEVFLQ 326
VSW KD L ++ +L ++ V +G Y C SN G GR V
Sbjct: 3704 VSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEP 3763
Query: 327 VQYAPEPSTVQIL-HSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPK 385
AP PS + + H+PA+ C + +P P W+ +G+++ R ++ + +
Sbjct: 3764 PAIAPSPSNLTLTAHTPAL------LPCEASGSPKPL-VVWWKDGQKLDFRLQQGAY--R 3814
Query: 386 ILPWHA-----------GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIRE 434
+LP +A + CV N +G R ++ V PP Q +
Sbjct: 3815 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRL--YQVTVHVPPTIADD--QTDFTVTM 3870
Query: 435 GDTVTLSCNYNSSNPSVTRYEWKPHGA--------WEEPSLGVLKI-QNVGWDNTTIACA 485
V L+C +++ P+ T W GA + G L+I Q + C+
Sbjct: 3871 MAPVVLTC-HSTGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 3928
Query: 486 ACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSG---NSVSLQCDFSSSHPKEVQFF 542
A NS V L VQ +P +KPL + V L C+ +S P+
Sbjct: 3929 ARNSAGVAHKHVFLTVQASP------VVKPLPSVVRAVAEEEVLLPCE-ASGIPRPT-IT 3980
Query: 543 WEKNGRLLGKE--------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPR 594
W+K G + QL SPEDAG+Y C NS G K T V+ P
Sbjct: 3981 WQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK--TRLVVQVPP 4038
Query: 595 RLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEP------ 648
+ + P EG A L C++ +P + TW D + Q + K ++P
Sbjct: 4039 VIENGL-PDLSTTEGSHAFLPCKARGSPE-PNITW-DKDGQPVSGAEGKFTIQPSGELLV 4095
Query: 649 --VKVQHSGAYWCQGTNSVGKGR 669
++ Q +G Y C N+VG+ R
Sbjct: 4096 KNLEGQDAGTYTCTAENAVGRAR 4118
Score = 77.0 bits (188), Expect = 7e-14
Identities = 119/451 (26%), Positives = 175/451 (38%), Gaps = 74/451 (16%)
Query: 261 VTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSN 313
V +TC S+ TVSW K G L + + L + + +G+Y C N
Sbjct: 3874 VVLTCH--STGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN 3931
Query: 314 DVGPGRSEEVFLQVQYAPE----PSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHN 369
G + VFL VQ +P PS V+ AV +V C + P PT TW
Sbjct: 3932 SAGVAH-KHVFLTVQASPVVKPLPSVVR-----AVAEEEVLLPCEASGIPRPT-ITWQKE 3984
Query: 370 GKEMQGRTEEKV------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVT 423
G + +V I P AG Y C+A+N G+ L VQ PP
Sbjct: 3985 GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK--TRLVVQVPP---- 4038
Query: 424 TVIQNPMP---IREGDTVTLSCNYNSS-NPSVT-RYEWKPHGAWE-----EPSLGVLKIQ 473
VI+N +P EG L C S P++T + +P E +PS G L ++
Sbjct: 4039 -VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPS-GELLVK 4096
Query: 474 NV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFS 532
N+ G D T C A N+ V L + P + + L G+ + L+C
Sbjct: 4097 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---RLGDRLWLRCAAR 4153
Query: 533 SSHPKEVQFFWEKNGRLLGKE-------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAW 585
S + W N R + + S L ++S ED+G+Y CW N +G+T + ++
Sbjct: 4154 GSPTPRIG--WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF 4211
Query: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYTWFDWNNQSLPYHSQKL 644
+ V AP + S + + G S L C +P P H W LP L
Sbjct: 4212 -VHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVRGDPVPDIH-----WIKDGLPLRGSHL 4264
Query: 645 R---------LEPVKVQHSGAYWCQGTNSVG 666
R + + +G Y C N +G
Sbjct: 4265 RHQLQNGSLTIHRTERDDAGRYQCLAENEMG 4295
Score = 76.3 bits (186), Expect = 1e-13
Identities = 84/348 (24%), Positives = 142/348 (40%), Gaps = 35/348 (10%)
Query: 392 GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV 451
GTY C A + GTG+ A++ V PP ++ + + G+T LSC P
Sbjct: 492 GTYECTAVSRAGTGRAK--AQIVVTDPPPQLVPAPN--VTVSPGETAVLSCRVLGEAPYN 547
Query: 452 TRY--EWK--PHGAWEEPSLGVLKIQNVG---WDNTTIACAACNSWCSWASPVALNVQYA 504
+ +W+ P L L ++ G D C A N+ + V L V+ A
Sbjct: 548 LTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA 607
Query: 505 PRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDS---- 560
P+ V + S H V ++ S+S W + + L ++S+++ D+
Sbjct: 608 PQ-VSIHT----SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTL 662
Query: 561 ----ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTC 616
++PEDAG+YSC N +G T+ + Y +++ V G+ A L C
Sbjct: 663 IIQGVAPEDAGNYSCQATNEVGTDQE---TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 719
Query: 617 ESDANPPVSHYTWFDWNNQSL----PYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672
E+ PP W+ + + S KLR+ + + +G Y C+ N +G + +
Sbjct: 720 EASGVPP-PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 778
Query: 673 STLTVYYSPE--TIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQ 718
L V ++P+ + R V V LG + A W+R Q
Sbjct: 779 Q-LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 825
Score = 73.2 bits (178), Expect = 1e-12
Identities = 140/607 (23%), Positives = 222/607 (36%), Gaps = 121/607 (19%)
Query: 151 IQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209
+ E Q V+L C++ G P+ + WL +G P+ + S+ L
Sbjct: 896 VLEGQPVSLPCIV---LAGRPLPERHWLKDGRPLPPGSR-------HSIRADGSLHLDRA 945
Query: 210 WSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSS 269
H +C + G + V+L V+ P+ I T + I EG ++ C V+S
Sbjct: 946 LQEHAGRYSCVATNTAGS--QHRDVELVVQVPPR--IHPTATHHITNEGVPASLPC-VAS 1000
Query: 270 SNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVGPGRSEE 322
P T++W K+ +L + TL + + + +G Y C +N VG S+E
Sbjct: 1001 GVPA-PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS-SQE 1058
Query: 323 VFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVH 382
+ L V L +S Y W G G +
Sbjct: 1059 MRLSVNR----------------------LALS-------KYVWEEYGLLPSG----SLR 1085
Query: 383 IPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNP--MPIREGDTVTL 440
+ ++ +G Y C A N G+ L VQ PP+ V P + + G+ + L
Sbjct: 1086 LAQVQVGDSGHYECTASNPAGSASHR--YVLGVQVPPQ----VQPGPRVLKVLVGEALDL 1139
Query: 441 SCNYNSSNPSVTRYEWKPHGA-----WEEPSLGVLKIQNVGWDNTTIACAACNSWCSWAS 495
+C NP + W G + S+ I+ D C A NS A
Sbjct: 1140 NC-VAEGNPE-PQLSWSKDGVVLQGRGPQGSVHFAAIRTS--DAGRYRCEASNSAGVDAW 1195
Query: 496 PVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKN--------- 546
V L V P + L E +G + SL C + PK Q W K
Sbjct: 1196 EVELRVLEPPH-WGADETSGLLERVAGENASLPCPARGT-PKP-QVTWRKGPSSEPLHGQ 1252
Query: 547 -GRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD- 604
G + +E L S+SP D+G Y C N +G T+ +A V+Y P +R +
Sbjct: 1253 PGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKL--VVYVPPSIREDGRKANV 1310
Query: 605 QVMEGKSATLTCESDANPPVSHYTW---------------FDWN-------NQSLPYHSQ 642
M G+S TL C+++ PV W + W+ L Q
Sbjct: 1311 SGMAGQSLTLECDANGF-PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 1369
Query: 643 KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILA 702
L ++ SG Y C+ N G + L + +P ++ +G G+ +L LA
Sbjct: 1370 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL--TPPSV-----LGAGAAQEVLGLA 1422
Query: 703 ICGLKLQ 709
++LQ
Sbjct: 1423 GADVELQ 1429
Score = 72.8 bits (177), Expect = 1e-12
Identities = 107/436 (24%), Positives = 168/436 (38%), Gaps = 65/436 (14%)
Query: 294 LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP--EPSTVQILHSPAVEGSQVEF 351
L + +V G Y C +N G + EV L+V P EP V + +E + V
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESK-REVALKVLVPPNIEPGPV---NKAVLENASVTL 1905
Query: 352 LCMSLANPLPTNYTWYHNGK----------EMQGRTEEKVHIPKILPWHAGTYSCVAENI 401
C++ P P + +W+ + + GR + I + AG+Y CVA N+
Sbjct: 1906 ECLASGVP-PPDVSWFKGHQPVSSWMGVTVSVDGRV---LRIEQAQLSDAGSYRCVASNV 1961
Query: 402 LGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGA 461
G+ + G ++V P ++T P P+ V L+CN + PS T W G
Sbjct: 1962 AGSTELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGA-PSPT-LMWLKDGN 2016
Query: 462 WEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS--- 517
P+ G +Q G T+A A + ++ V +DV ++ P S
Sbjct: 2017 PVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 2075
Query: 518 -----EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR---------LLGKESQLNFDSISP 563
+ + SV+L+C + P + W K+GR L ++ L D
Sbjct: 2076 EELNVSVVANESVALECQSHAMPPPVLS--WWKDGRPLEPRPGVHLSADKALLQVDRADV 2133
Query: 564 EDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
DAG Y+C N G + K + L V AP + S V EG +L+CE P
Sbjct: 2134 WDAGHYTCEALNQAGH-SEKHYNLNVWVAP-VFPLRESHTLTVREGHPTSLSCECRGVP- 2190
Query: 624 VSHYTWFDWNNQSLPYHSQKLRLEPV------------KVQHSGAYWCQGTNSVGKGRSP 671
+ W P + L+ V ++ G Y C+ +N VG
Sbjct: 2191 ---FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 2247
Query: 672 LSTLTVYYSPETIGRR 687
L L V+ P+ G R
Sbjct: 2248 LQ-LEVHVPPQIAGPR 2262
Score = 69.3 bits (168), Expect = 1e-11
Identities = 127/557 (22%), Positives = 203/557 (36%), Gaps = 98/557 (17%)
Query: 204 LKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTM 263
LK + + +C + G+ N +V++ V P +E + V +G + +
Sbjct: 2408 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP--PSIENEDLEEVIKVLDGQTAHL 2465
Query: 264 TCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVG 316
C V+ +P+ ++W KDG L + + L + + +G Y C +N VG
Sbjct: 2466 MCNVTG-HPQ-PKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVG 2523
Query: 317 PGRSEEVFLQVQYAP-----------EPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
+++ L V AP E TV + + + +C +LA P P N T
Sbjct: 2524 E-KTKHFQLSVLLAPTILGGAEDSADEEVTVTV-------NNPISLICEALAFPSP-NIT 2574
Query: 366 WYHNGKEMQGRTEEKV----HIPKILPWH---AGTYSCVAENILGTGQRGPGAELDVQYP 418
W +G + ++ H +IL AG Y+CV N LG + ++V P
Sbjct: 2575 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN--YHVEVLIP 2632
Query: 419 PKKVTTVIQNPMPIRE-----GDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPS-----LG 468
P + ++E T+TL C + P R W G PS LG
Sbjct: 2633 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLG 2690
Query: 469 ---VLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--- 521
+L+IQ D+ C A N + +Q P +V EI S
Sbjct: 2691 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 2750
Query: 522 --------------GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDS 560
N L CD ++ P ++ ++ E G E L
Sbjct: 2751 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL 2810
Query: 561 ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT--LTCES 618
+ E+AG YSC +N +G+ + L VL P L + ++V S+T L C +
Sbjct: 2811 VRAENAGRYSCKASNEVGEDWLH-YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPA 2869
Query: 619 DANPPVSHYTWFDWNNQSLPY----------HSQKLRLEPVKVQHSGAYWCQGTNSVGKG 668
NP + W LP+ Q L++ +V + +Y C N G
Sbjct: 2870 LGNPVPT----ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 2925
Query: 669 RSPLSTLTVYYSPETIG 685
L TL V P G
Sbjct: 2926 EK-LFTLRVQVPPRIAG 2941
Score = 67.8 bits (164), Expect = 4e-11
Identities = 142/655 (21%), Positives = 243/655 (37%), Gaps = 92/655 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG + +Q L + L I D+GQ + ++ + ++ H+ V
Sbjct: 2577 KDGAPFEASRNIQLLPGTHG---LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--- 2630
Query: 141 FPPHIQLPPEIQE----SQEVTLTCLLNFSCYGY---PIQLQWLLEGVPMRQAAVTSTSL 193
PP I + E + + L C + P ++W +G P+ + S
Sbjct: 2631 IPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV------TPSS 2684
Query: 194 TIKSVFTRSELKFSP-QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD 252
++ + L+ P Q S G+ + C + G+ + V + V P + KV
Sbjct: 2685 RLQVLGEGRLLQIQPTQVSDSGRYL-CVATNVAGEDDQDFNVLIQV---PPMFQKVGDFS 2740
Query: 253 A----IVREGDS---VTMTCEVSSSNPEYT----------TVSWLKDGTSLKK------- 288
A + RE ++ VT E+ +NP Y ++W ++ L
Sbjct: 2741 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVL 2800
Query: 289 QNTFTLNLREVTKDQSGKYCCQVSNDVGPG-RSEEVFLQVQYAPEPSTVQILHSPAVEGS 347
Q L + V + +G+Y C+ SN+VG E+ + T +++ V S
Sbjct: 2801 QGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 2860
Query: 348 Q-VEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAE 399
V C +L NP+PT +W NG +V + A +Y CVAE
Sbjct: 2861 STVSLQCPALGNPVPT-ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 2919
Query: 400 NILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKP 458
N G+ ++ L VQ PP+ ++ I +V+L C+ ++ NP VT Y+
Sbjct: 2920 NQAGSAEK--LFTLRVQVPPRIAGLDLEQVTAIL-NSSVSLPCDVHAHPNPEVTWYKDSQ 2976
Query: 459 HGAWEE-----PSLGVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRV-R 511
+ E P L++ D+ C A N+ V L+V P + R
Sbjct: 2977 ALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPR 3036
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDSISPE 564
+ + G+ L C+ + V ++ + +L + +Q L
Sbjct: 3037 GPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVS 3096
Query: 565 DAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPV 624
D G YSC V+N G+ A + +TL V P QV G LTC+ P
Sbjct: 3097 DKGLYSCKVSNVAGE-AVRTFTLTVQVPPTFENPKTETVSQV-AGSPLVLTCDVSGVPAP 3154
Query: 625 SHYTWFDWNNQSLPYHSQ----------KLRLEPVKVQHSGAYWCQGTNSVGKGR 669
+ W +P S +L+L ++ +G Y C N+ + R
Sbjct: 3155 T----VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR 3205
Score = 56.2 bits (134), Expect = 1e-07
Identities = 89/411 (21%), Positives = 148/411 (36%), Gaps = 50/411 (12%)
Query: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFL 352
+L+ + + SG Y C+ N G + + L + + G+ VE
Sbjct: 1370 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQ 1429
Query: 353 CMSLANPLPTNYTWYHN-------GKEMQGRTEEKVHIPKILPWHAGT---YSCVAENIL 402
C + P P W + G +Q +E + +I H G Y CVA +
Sbjct: 1430 CWTSGVPTP-QVEWTKDRQPVLPGGPHLQ--VQEDGQVLRITGSHVGDEGRYQCVAFS-- 1484
Query: 403 GTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKPHGA 461
GQ+ +L V PP + + + E V L C P++T W GA
Sbjct: 1485 PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT---WFKDGA 1541
Query: 462 WEEPSLGVLKIQN---------VGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
S V+ + D C A N+ + L+V Y P +
Sbjct: 1542 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAG 1600
Query: 513 IKP-LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSIS 562
+P + + +G V+L+C + HP W G RL S L +S
Sbjct: 1601 GRPYVVKAVAGRPVALEC-VARGHPSPT-LSWHHEGLPVAESNESRLETDGSVLRLESPG 1658
Query: 563 PEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP 622
+G YSC ++ G+ + +++EV P+ L + G+ L C++ +P
Sbjct: 1659 EASSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 1717
Query: 623 PVSHYTWFDWNNQS-------LPYHSQKLRLEPVKVQHSGAYWCQGTNSVG 666
V W + + L ++ V++ HSG + CQ TN G
Sbjct: 1718 -VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767
Score = 55.8 bits (133), Expect = 2e-07
Identities = 48/185 (25%), Positives = 81/185 (43%), Gaps = 26/185 (14%)
Query: 236 LNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN----- 290
++VK P L+ + S + G S+ + C V + W+KDG L+ +
Sbjct: 4212 VHVKEAPVLQGEAF-SYLVEPVGGSIQLDCVVRGD--PVPDIHWIKDGLPLRGSHLRHQL 4268
Query: 291 -TFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP----EPSTVQILHSPAVE 345
+L + +D +G+Y C N++G + + V L +Q AP EP + +
Sbjct: 4269 QNGSLTIHRTERDDAGRYQCLAENEMGVAK-KVVILVLQSAPVFQVEPQDMTVR-----S 4322
Query: 346 GSQVEFLCMSLANPLPTNYTWYHNGKEMQG----RT--EEKVHIPKILPWHAGTYSCVAE 399
G V C + P PT W G+ ++ RT + + + + AGTY CVA
Sbjct: 4323 GDDVALRCQATGEPTPT-IEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAH 4381
Query: 400 NILGT 404
N+LG+
Sbjct: 4382 NLLGS 4386
Score = 50.8 bits (120), Expect = 5e-06
Identities = 85/375 (22%), Positives = 142/375 (37%), Gaps = 69/375 (18%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK-KQNTFTLN------LREVTKDQS 304
D EG + C+ S PE ++W KDG + + FT+ ++ + +
Sbjct: 4046 DLSTTEGSHAFLPCKARGS-PE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 4103
Query: 305 GKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNY 364
G Y C N VG R V L + P +T+ S + G ++ C + +P P
Sbjct: 4104 GTYTCTAENAVGRAR-RRVHLTILVLPVFTTLPGDRSLRL-GDRLWLRCAARGSPTP-RI 4160
Query: 365 TWYHNGKEMQGRTEEK-----VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPP 419
W N + + E+ + + +GTY C AEN +G Q V +
Sbjct: 4161 GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA-------VSFVH 4213
Query: 420 KKVTTVIQNPM------PIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSL------ 467
K V+Q P+ G ++ L C V R + P W + L
Sbjct: 4214 VKEAPVLQGEAFSYLVEPV--GGSIQLDC--------VVRGDPVPDIHWIKDGLPLRGSH 4263
Query: 468 -------GVLKIQNVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS-E 518
G L I D+ C A N V L +Q AP V +++P
Sbjct: 4264 LRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP----VFQVEPQDMT 4319
Query: 519 IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLN--------FDSISPEDAGSYS 570
+ SG+ V+L+C + ++ W + G+ L +L +++ DAG+Y
Sbjct: 4320 VRSGDDVALRCQATGEPTPTIE--WLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 4377
Query: 571 CWVNNSIGQTASKAW 585
C +N +G ++A+
Sbjct: 4378 CVAHNLLGSATARAF 4392
Score = 43.5 bits (101), Expect = 8e-04
Identities = 130/610 (21%), Positives = 208/610 (34%), Gaps = 88/610 (14%)
Query: 103 TLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCL 162
+L + V DSG S+ + L V E PPHI+ + + E++LT
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME---PPHIE---DSGQPTELSLTP- 3509
Query: 163 LNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQ 222
G P++L +G P + + S + G + TC +
Sbjct: 3510 ------GAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAG-LYTCLAE 3562
Query: 223 DADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKD 282
G + ++ V+ P + P + + + C V + ++W +D
Sbjct: 3563 SPAGAI--EKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP--KITWHRD 3618
Query: 283 GTSLKK-------QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPST 335
G L++ + L L+ ++ SG Y C N G V + E T
Sbjct: 3619 GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS-------TSVAFRVEIHT 3671
Query: 336 VQILHS--PAVEGS--QVEFL-CMSLANPLPTNYTWYHNGKEMQGRT-------EEKVHI 383
V + S PAV S Q L C + P P +W + + R+ E + I
Sbjct: 3672 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPL-VSWRKDRVPLDPRSPRFEILPEGSLRI 3730
Query: 384 PKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCN 443
+L AG Y C+A N G+ ++ G +L V PP + + + + L C
Sbjct: 3731 QPVLAQDAGHYLCLASNSAGSDRQ--GRDLRVLEPPAIAPS--PSNLTLTAHTPALLPCE 3786
Query: 444 YNSSNPSVTRYEWK---------PHGAWE-EPSLGVLKIQNVGWDNTTIACAACNSWCSW 493
S +P WK GA+ PS +L D+ C N
Sbjct: 3787 -ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEA 3845
Query: 494 ASPVALNVQYAP------RDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG 547
+ V P D V + P+ + + +S + S Q +G
Sbjct: 3846 HRLYQVTVHVPPTIADDQTDFTVTMMAPV--VLTCHSTGIPAPTVSWSKAGAQLGARGSG 3903
Query: 548 RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVM 607
+ L P AG Y+C NS G A K L V +P + P V+
Sbjct: 3904 YRVSPSGALEIGQALPIHAGRYTCSARNSAG-VAHKHVFLTVQASP-----VVKPLPSVV 3957
Query: 608 EG---KSATLTCESDANPPVSHYTW--------FDWNNQSLPYHSQKLRLEPVKVQHSGA 656
+ L CE+ P + TW + Q LP +LR+ + +G
Sbjct: 3958 RAVAEEEVLLPCEASGIPRPT-ITWQKEGLNVATGVSTQVLP--GGQLRIAHASPEDAGN 4014
Query: 657 YWCQGTNSVG 666
Y C NS G
Sbjct: 4015 YLCIAKNSAG 4024
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 109 bits (272), Expect = 1e-23
Identities = 140/557 (25%), Positives = 225/557 (40%), Gaps = 70/557 (12%)
Query: 151 IQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQW 210
+ E QEV L C + P + WL +G P+ Q ++ L
Sbjct: 1947 VLEGQEVRLDCEADGQP---PPDVAWLKDGSPLGQ----DMGPHLRFYLDGGSLVLKGLR 1999
Query: 211 SHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV-REGDSVTMTCEVSS 269
+ TC + G+ TV NV P ++ S +V R G+ VTM C V
Sbjct: 2000 ASDAGAYTCVAHNPAGEDARLHTV--NVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRG 2057
Query: 270 SNPEYTTVSWLKDGTSLK-KQNTF------TLNLREVTKDQSGKYCCQVSNDVGPGRSEE 322
S P + VSWLKDG L Q T TL + +V +G + C ++ G
Sbjct: 2058 SPPIH--VSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVA-DRN 2114
Query: 323 VFLQVQYAPEPSTVQILHSPAV-EGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK- 380
LQVQ P V+ + V GS VE C + PLP +W +G+ + ++ E+
Sbjct: 2115 FTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPL-VSWMKDGEPLLSQSLEQG 2173
Query: 381 --VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTV 438
+ + + +GTYSCVA + G +R +L V PP + + + G +
Sbjct: 2174 PSLQLEAVGAGDSGTYSCVAVSEAGEARRH--FQLTVMEPPHIEDSGQPTELSLTPGAPM 2231
Query: 439 TLSCNYNSS-NPSVTRYEWKPHGAW------EEPSLGVLKIQNVGWDNTTIACAACNSWC 491
L C+ + P++T W G + VL++++ G C A +
Sbjct: 2232 ELLCDAQGTPQPNIT---WHKDGQALTRLENNSRATRVLRVRDAG----LYTCLAESPAG 2284
Query: 492 SWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG 551
+ + VQ P V R + + + G V L+C + ++ W ++G +L
Sbjct: 2285 AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKIT--WHRDGIVLQ 2341
Query: 552 KESQLNF---------DSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSP 602
+++ F ++S D+G YSC N+ G T S A+ +E+ P +R S P
Sbjct: 2342 EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTVPT-IR-SGPP 2398
Query: 603 GDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQK----------LRLEPVKVQ 652
V ++A L C++D P W +P + LR++PV Q
Sbjct: 2399 AVNVSVNQTALLPCQADGVPA----PLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQ 2454
Query: 653 HSGAYWCQGTNSVGKGR 669
+G Y C +NS G R
Sbjct: 2455 DAGHYLCLASNSAGSDR 2471
Score = 94.0 bits (232), Expect = 5e-19
Identities = 155/657 (23%), Positives = 250/657 (38%), Gaps = 98/657 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG+ + V DK L + + D+G ++ + +LNV P
Sbjct: 824 KDGRPLEPRPGVHLSADK---ALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP 880
Query: 141 -FPPHIQLPPEIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSV 198
FP ++E L+C C G P ++ W +G P+ L S
Sbjct: 881 VFPLRESHTLTVREGHPTRLSC----ECRGVPFPKISWRKDGQPLPGEGA---GLQHVSA 933
Query: 199 FTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLE-IKVTPSDAIVRE 257
R Q + G TC+ + G S+ +QL V P++ + P+ V +
Sbjct: 934 VGRLLYLGQAQLAQEGTY-TCECSNVVGN--SSQDLQLEVHVPPQIAGPREPPTQVSVVQ 990
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGT------SLKKQNTF-TLNLREVTKDQSGKYCCQ 310
T+ C + P TV+W +DG L+ QN +L++ +G+Y C
Sbjct: 991 DGVATLECNATGKPPP--TVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCV 1048
Query: 311 VSNDVGPGRSEEVF-LQVQYAPE--------PSTVQILHSPAVEGSQVEFLCMSLANPLP 361
N G R+E F L V PE + LHSP + LC ++ P P
Sbjct: 1049 AENLAG--RAERKFELSVLVPPELIGDLDPLTNITAALHSP------LTLLCEAMGIPPP 1100
Query: 362 TNYTWYHNGKEMQGRTEEK--------VHIPKILPWHAGTYSCVAENILGTGQRGPGAEL 413
W+ G+E E+ + + + +G YSC+A N G +R E+
Sbjct: 1101 A-IRWFR-GEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1158
Query: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSS-NPSVTRY-EWKPHGAWE----EPSL 467
V PP ++ + + +G T L CN P +T + + +P + P
Sbjct: 1159 LV--PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDG 1216
Query: 468 GVLKIQNVGWDNTT-IACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--GNS 524
+L++ + +C A N+ L+V AP + + E+ N
Sbjct: 1217 VLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP 1276
Query: 525 VSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSISPEDAGSYSCWVNN 575
+SL C+ + + W K+G +LL L + EDAG Y+C V N
Sbjct: 1277 ISLICEALAFPSPNIT--WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN 1334
Query: 576 SIGQTASKAWTLEVLYAPRRLRVSMSPGDQVME----------GKSATLTCESDANPPVS 625
+G+ A K + +EVL P S+S D + E + TL CES A PP +
Sbjct: 1335 ELGE-AVKNYHVEVLIPP-----SISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPT 1388
Query: 626 HYTWFDWNNQSLPY-------HSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTL 675
W+ P + L+++P +V SG Y C TN G+ + L
Sbjct: 1389 -IRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVL 1444
Score = 86.3 bits (212), Expect = 1e-16
Identities = 151/624 (24%), Positives = 236/624 (37%), Gaps = 102/624 (16%)
Query: 139 RPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVP------MRQAAVTSTS 192
R F + PP I S E ++ + +QL GVP + A+ TS
Sbjct: 209 RDFQLRVHAPPTIWGSNETGEVAVME----DHLVQLLCEARGVPTPNITWFKDGALLPTS 264
Query: 193 LTIKSVFTRS--ELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLE-IKVT 249
K V+TR +L+ S + TC+ +A G + +L+V P +E
Sbjct: 265 T--KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA--AEKATRLDVYVPPTIEGAGGR 320
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKD 302
P G V + C V+ +P T+SW +G + + N L L +
Sbjct: 321 PYVVKAVAGRPVALEC-VARGHPS-PTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA 378
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHS-PAVEGSQVEFLCMSLANPLP 361
SG Y C S+ G + ++VQ P+ + L + G +E C + +P+P
Sbjct: 379 SSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP 437
Query: 362 TNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAENILGTGQRGPGAELD 414
T W NG+ + +V HI + H+G ++C A N GT GAE++
Sbjct: 438 T-IQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA----GAEVE 492
Query: 415 VQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW-------------KPHGA 461
V + V++ P+ S + +P V R W P
Sbjct: 493 VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHR-GWGAHPKPPLVEGWCSPGSL 551
Query: 462 WEEPSLGV---------LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511
W EP+ G+ L+I+ V D CAA N VAL V P +
Sbjct: 552 WGEPT-GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIE 607
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFF--------W-----EKNGRLLG-KESQLN 557
+ SV+L+C S P +V +F W +GR+L +++QL+
Sbjct: 608 PGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLS 667
Query: 558 FDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCE 617
DAGSY C +N G T + + L V PR PG V+ LTC
Sbjct: 668 -------DAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPG-PVLVNTPVRLTCN 718
Query: 618 SDANPPVSHYTWFDWNNQSLPYHSQKLRLEP---------VKVQHSGAYWCQGTNSVGKG 668
+ P + W N P + L++ P + SG Y C ++VG+
Sbjct: 719 ATGAPSPT-LMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777
Query: 669 RSPLSTLTVYYSPETIGRRVAVGL 692
R + L V+ P +G + V +
Sbjct: 778 RQDV-VLQVHMPPSILGEELNVSV 800
Score = 84.7 bits (208), Expect = 3e-16
Identities = 110/469 (23%), Positives = 191/469 (40%), Gaps = 50/469 (10%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK-------QNTFTLNLREVTKDQS 304
+ V +V++ C + NP T+SWL++G ++ L + +
Sbjct: 1572 EVTVNASSTVSLQCP-ALGNP-VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADA 1629
Query: 305 GKYCCQVSNDVGPGRSEEVF-LQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTN 363
Y C N G +E++F L+VQ P + + + A+ S V C A+P P
Sbjct: 1630 ASYMCVAENQAGS--AEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNP-E 1686
Query: 364 YTWYHNGKEMQGRTE-------EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQ 416
TWY + + + E + + + +G Y+C A N G Q+ +L V
Sbjct: 1687 VTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL--VQLSVL 1744
Query: 417 YPP--KKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKPHGAWEEPSLGV---- 469
PP ++ Q+ + +R GD LSC ++ P+VT Y+ + + +
Sbjct: 1745 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1804
Query: 470 -LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSL 527
L+IQ D +C N L VQ P K + +S++ +G+ + L
Sbjct: 1805 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPT-FENPKTETVSQV-AGSPLVL 1862
Query: 528 QCDFSSSHPKEVQFFWEKNG-------RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQT 580
CD S V + ++ ++ + +L + P AG+Y+C N+ +
Sbjct: 1863 TCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE- 1921
Query: 581 ASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWN--NQSLP 638
A K + + VL APR ++ V+EG+ L CE+D PP D + Q +
Sbjct: 1922 ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 1981
Query: 639 YHSQ------KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
H + L L+ ++ +GAY C N G+ + L T+ V P
Sbjct: 1982 PHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED-ARLHTVNVLVPP 2029
Score = 79.3 bits (194), Expect = 1e-14
Identities = 112/443 (25%), Positives = 174/443 (39%), Gaps = 78/443 (17%)
Query: 277 VSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVGP---GRSEEVFLQ 326
VSW KD L ++ +L ++ V +G Y C SN G GR V
Sbjct: 2422 VSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEP 2481
Query: 327 VQYAPEPSTVQIL-HSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPK 385
AP PS + + H+PA+ C + +P P W+ +G+++ R ++ + +
Sbjct: 2482 PAIAPSPSNLTLTAHTPAL------LPCEASGSPKPL-VVWWKDGQKLDFRLQQGAY--R 2532
Query: 386 ILPWHA-----------GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIRE 434
+LP +A + CV N +G R ++ V PP Q +
Sbjct: 2533 LLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRL--YQVTVHVPPTIADD--QTDFTVTM 2588
Query: 435 GDTVTLSCNYNSSNPSVTRYEWKPHGA--------WEEPSLGVLKI-QNVGWDNTTIACA 485
V L+C +++ P+ T W GA + G L+I Q + C+
Sbjct: 2589 MAPVVLTC-HSTGIPAPT-VSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCS 2646
Query: 486 ACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSG---NSVSLQCDFSSSHPKEVQFF 542
A NS V L VQ +P +KPL + V L C+ +S P+
Sbjct: 2647 ARNSAGVAHKHVFLTVQASP------VVKPLPSVVRAVAEEEVLLPCE-ASGIPRPT-IT 2698
Query: 543 WEKNGRLLGKE--------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPR 594
W+K G + QL SPEDAG+Y C NS G K T V+ P
Sbjct: 2699 WQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK--TRLVVQVPP 2756
Query: 595 RLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEP------ 648
+ + P EG A L C++ +P + TW D + Q + K ++P
Sbjct: 2757 VIENGL-PDLSTTEGSHAFLPCKARGSPE-PNITW-DKDGQPVSGAEGKFTIQPSGELLV 2813
Query: 649 --VKVQHSGAYWCQGTNSVGKGR 669
++ Q +G Y C N+VG+ R
Sbjct: 2814 KNLEGQDAGTYTCTAENAVGRAR 2836
Score = 77.0 bits (188), Expect = 7e-14
Identities = 119/451 (26%), Positives = 175/451 (38%), Gaps = 74/451 (16%)
Query: 261 VTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSN 313
V +TC S+ TVSW K G L + + L + + +G+Y C N
Sbjct: 2592 VVLTCH--STGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN 2649
Query: 314 DVGPGRSEEVFLQVQYAPE----PSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHN 369
G + VFL VQ +P PS V+ AV +V C + P PT TW
Sbjct: 2650 SAGVAH-KHVFLTVQASPVVKPLPSVVR-----AVAEEEVLLPCEASGIPRPT-ITWQKE 2702
Query: 370 GKEMQGRTEEKV------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVT 423
G + +V I P AG Y C+A+N G+ L VQ PP
Sbjct: 2703 GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGK--TRLVVQVPP---- 2756
Query: 424 TVIQNPMP---IREGDTVTLSCNYNSS-NPSVT-RYEWKPHGAWE-----EPSLGVLKIQ 473
VI+N +P EG L C S P++T + +P E +PS G L ++
Sbjct: 2757 -VIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPS-GELLVK 2814
Query: 474 NV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFS 532
N+ G D T C A N+ V L + P + + L G+ + L+C
Sbjct: 2815 NLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSL---RLGDRLWLRCAAR 2871
Query: 533 SSHPKEVQFFWEKNGRLLGKE-------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAW 585
S + W N R + + S L ++S ED+G+Y CW N +G+T + ++
Sbjct: 2872 GSPTPRIG--WTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF 2929
Query: 586 TLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYTWFDWNNQSLPYHSQKL 644
+ V AP + S + + G S L C +P P H W LP L
Sbjct: 2930 -VHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVRGDPVPDIH-----WIKDGLPLRGSHL 2982
Query: 645 R---------LEPVKVQHSGAYWCQGTNSVG 666
R + + +G Y C N +G
Sbjct: 2983 RHQLQNGSLTIRRTERDDAGRYQCLAENEMG 3013
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/436 (24%), Positives = 167/436 (38%), Gaps = 65/436 (14%)
Query: 294 LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP--EPSTVQILHSPAVEGSQVEF 351
L + +V G Y C +N G + EV L+V P EP V + +E + V
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESK-REVALKVLVPPNIEPGPV---NKAVLENASVTL 623
Query: 352 LCMSLANPLPTNYTWYHNGK----------EMQGRTEEKVHIPKILPWHAGTYSCVAENI 401
C++ P P + +W+ + + GR + I + AG+Y CVA N+
Sbjct: 624 ECLASGVP-PPDVSWFKGHQPVSSWMGVTVSVDGRV---LRIEQAQLSDAGSYRCVASNV 679
Query: 402 LGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGA 461
G+ + G ++V P ++T P P+ V L+CN + PS T W G
Sbjct: 680 AGSTELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGA-PSPT-LMWLKDGN 734
Query: 462 WEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS--- 517
P+ G +Q G T+A A + ++ V +DV ++ P S
Sbjct: 735 PVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILG 793
Query: 518 -----EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR---------LLGKESQLNFDSISP 563
+ + SV+L+C + P + W K+GR L ++ L D
Sbjct: 794 EELNVSVVANESVALECQSHAMPPPVLS--WWKDGRPLEPRPGVHLSADKALLQVDRADV 851
Query: 564 EDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
DAG Y+C N G + K + L V AP + S V EG L+CE P
Sbjct: 852 WDAGHYTCEALNQAGH-SEKHYNLNVWVAP-VFPLRESHTLTVREGHPTRLSCECRGVP- 908
Query: 624 VSHYTWFDWNNQSLPYHSQKLRLEPV------------KVQHSGAYWCQGTNSVGKGRSP 671
+ W P + L+ V ++ G Y C+ +N VG
Sbjct: 909 ---FPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 965
Query: 672 LSTLTVYYSPETIGRR 687
L L V+ P+ G R
Sbjct: 966 LQ-LEVHVPPQIAGPR 980
Score = 70.1 bits (170), Expect = 8e-12
Identities = 127/557 (22%), Positives = 203/557 (36%), Gaps = 98/557 (17%)
Query: 204 LKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTM 263
LK + + +C + G+ N +V++ V P +E + V +G + +
Sbjct: 1126 LKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP--PSIENEDLEEVIKVLDGQTAHL 1183
Query: 264 TCEVSSSNPEYTTVSWLKDGTSLKKQNTF-------TLNLREVTKDQSGKYCCQVSNDVG 316
C V+ +P+ ++W KDG L + + L + + +G Y C +N VG
Sbjct: 1184 MCNVTG-HPQ-PKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVG 1241
Query: 317 PGRSEEVFLQVQYAP-----------EPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
+++ L V AP E TV + + + +C +LA P P N T
Sbjct: 1242 E-KTKHFQLSVLLAPTILGGAEDSADEEVTVTV-------NNPISLICEALAFPSP-NIT 1292
Query: 366 WYHNGKEMQGRTEEKV----HIPKILPWH---AGTYSCVAENILGTGQRGPGAELDVQYP 418
W +G + ++ H +IL AG Y+CV N LG + ++V P
Sbjct: 1293 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN--YHVEVLIP 1350
Query: 419 PK-----KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPS-----LG 468
P + V + + T+TL C + P R W G PS LG
Sbjct: 1351 PSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR--WYKDGQPVTPSSRLQVLG 1408
Query: 469 ---VLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--- 521
+L+IQ D+ C A N + +Q P +V EI S
Sbjct: 1409 EGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREE 1468
Query: 522 --------------GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDS 560
N L CD ++ P ++ ++ E G E L
Sbjct: 1469 EARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPL 1528
Query: 561 ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSAT--LTCES 618
+ E+AG YSC +N +G+ + L VL P L + ++V S+T L C +
Sbjct: 1529 VRAENAGRYSCKASNEVGEDWLH-YELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPA 1587
Query: 619 DANPPVSHYTWFDWNNQSLPY----------HSQKLRLEPVKVQHSGAYWCQGTNSVGKG 668
NP + W LP+ Q L++ +V + +Y C N G
Sbjct: 1588 LGNPVPT----ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA 1643
Query: 669 RSPLSTLTVYYSPETIG 685
L TL V P G
Sbjct: 1644 EK-LFTLRVQVPPRIAG 1659
Score = 68.2 bits (165), Expect = 3e-11
Identities = 142/655 (21%), Positives = 243/655 (37%), Gaps = 92/655 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG + +Q L + L I D+GQ + ++ + ++ H+ V
Sbjct: 1295 KDGAPFEASRNIQLLPGTHG---LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL--- 1348
Query: 141 FPPHIQLPPEIQE----SQEVTLTCLLNFSCYGY---PIQLQWLLEGVPMRQAAVTSTSL 193
PP I + E + + L C + P ++W +G P+ + S
Sbjct: 1349 IPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV------TPSS 1402
Query: 194 TIKSVFTRSELKFSP-QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSD 252
++ + L+ P Q S G+ + C + G+ + V + V P + KV
Sbjct: 1403 RLQVLGEGRLLQIQPTQVSDSGRYL-CVATNVAGEDDQDFNVLIQV---PPMFQKVGDFS 1458
Query: 253 A----IVREGDS---VTMTCEVSSSNPEYT----------TVSWLKDGTSLKK------- 288
A + RE ++ VT E+ +NP Y ++W ++ L
Sbjct: 1459 AAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVL 1518
Query: 289 QNTFTLNLREVTKDQSGKYCCQVSNDVGPG-RSEEVFLQVQYAPEPSTVQILHSPAVEGS 347
Q L + V + +G+Y C+ SN+VG E+ + T +++ V S
Sbjct: 1519 QGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 1578
Query: 348 Q-VEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAE 399
V C +L NP+PT +W NG +V + A +Y CVAE
Sbjct: 1579 STVSLQCPALGNPVPT-ISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1637
Query: 400 NILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKP 458
N G+ ++ L VQ PP+ ++ I +V+L C+ ++ NP VT Y+
Sbjct: 1638 NQAGSAEK--LFTLRVQVPPRIAGLDLEQVTAIL-NSSVSLPCDVHAHPNPEVTWYKDSQ 1694
Query: 459 HGAWEE-----PSLGVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRV-R 511
+ E P L++ D+ C A N+ V L+V P + R
Sbjct: 1695 ALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPR 1754
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDSISPE 564
+ + G+ L C+ + V ++ + +L + +Q L
Sbjct: 1755 GPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVS 1814
Query: 565 DAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPV 624
D G YSC V+N G+ A + +TL V P QV G LTC+ P
Sbjct: 1815 DKGLYSCKVSNVAGE-AVRTFTLTVQVPPTFENPKTETVSQV-AGSPLVLTCDVSGVPAP 1872
Query: 625 SHYTWFDWNNQSLPYHSQ----------KLRLEPVKVQHSGAYWCQGTNSVGKGR 669
+ W +P S +L+L ++ +G Y C N+ + R
Sbjct: 1873 T----VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEAR 1923
Score = 57.8 bits (138), Expect = 4e-08
Identities = 91/353 (25%), Positives = 133/353 (37%), Gaps = 50/353 (14%)
Query: 379 EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTV 438
+ +H P+I +G YSC AEN GT QR L V PP + + G V
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQR--DFHLLVLTPPSVLGAGAAQEVLGLAGADV 144
Query: 439 TLSCNYNSSNPSVTRYEWK----------PHGAWEEPSLGVLKI--QNVGWDNTTIACAA 486
L C + S P+ + EW PH +E VL+I +VG D C A
Sbjct: 145 ELQC-WTSGVPT-PQVEWTKDRQPVLPGGPHLQVQEDG-QVLRITGSHVG-DEGRYQCVA 200
Query: 487 CNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKN 546
+ A L V +AP + + + V L C+ + W K+
Sbjct: 201 FSPAGQQARDFQLRV-HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT--WFKD 257
Query: 547 GRLLGKES---------QLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLR 597
G LL + QL DAG Y+C +N++G A KA L+V P
Sbjct: 258 GALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG-AAEKATRLDVYVPPTIEG 316
Query: 598 VSMSP-GDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQK----------LRL 646
P + + G+ L C + +P + W+++ LP LRL
Sbjct: 317 AGGRPYVVKAVAGRPVALECVARGHPSPT----LSWHHEGLPVAESNESRLETDGSVLRL 372
Query: 647 EPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAIL 699
E SG Y C ++ G+ S + V P+ + VA GLG I+
Sbjct: 373 ESPGEASSGLYSCVASSPAGEAVLQYS-VEVQVPPQLL---VAEGLGQVTTIV 421
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/185 (26%), Positives = 82/185 (44%), Gaps = 26/185 (14%)
Query: 236 LNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN----- 290
++VK P L+ + S + G S+ + C V + W+KDG L+ +
Sbjct: 2930 VHVKEAPVLQGEAF-SYLVEPVGGSIQLDCVVRGD--PVPDIHWIKDGLPLRGSHLRHQL 2986
Query: 291 -TFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP----EPSTVQILHSPAVE 345
+L +R +D +G+Y C N++G + + V L +Q AP EP + +
Sbjct: 2987 QNGSLTIRRTERDDAGRYQCLAENEMGVAK-KVVILVLQSAPVFQVEPQDMTVR-----S 3040
Query: 346 GSQVEFLCMSLANPLPTNYTWYHNGKEMQG----RT--EEKVHIPKILPWHAGTYSCVAE 399
G V C + P PT W G+ ++ RT + + + + AGTY CVA
Sbjct: 3041 GDDVALRCQATGEPTPT-IEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAH 3099
Query: 400 NILGT 404
N+LG+
Sbjct: 3100 NLLGS 3104
Score = 56.2 bits (134), Expect = 1e-07
Identities = 89/411 (21%), Positives = 148/411 (36%), Gaps = 50/411 (12%)
Query: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFL 352
+L+ + + SG Y C+ N G + + L + + G+ VE
Sbjct: 88 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQ 147
Query: 353 CMSLANPLPTNYTWYHN-------GKEMQGRTEEKVHIPKILPWHAGT---YSCVAENIL 402
C + P P W + G +Q +E + +I H G Y CVA +
Sbjct: 148 CWTSGVPTP-QVEWTKDRQPVLPGGPHLQ--VQEDGQVLRITGSHVGDEGRYQCVAFS-- 202
Query: 403 GTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS-SNPSVTRYEWKPHGA 461
GQ+ +L V PP + + + E V L C P++T W GA
Sbjct: 203 PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT---WFKDGA 259
Query: 462 WEEPSLGVLKIQN---------VGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRK 512
S V+ + D C A N+ + L+V Y P +
Sbjct: 260 LLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAG 318
Query: 513 IKP-LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSIS 562
+P + + +G V+L+C + HP W G RL S L +S
Sbjct: 319 GRPYVVKAVAGRPVALEC-VARGHPSPT-LSWHHEGLPVAESNESRLETDGSVLRLESPG 376
Query: 563 PEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP 622
+G YSC ++ G+ + +++EV P+ L + G+ L C++ +P
Sbjct: 377 EASSGLYSCVASSPAGEAVLQ-YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP 435
Query: 623 PVSHYTWFDWNNQS-------LPYHSQKLRLEPVKVQHSGAYWCQGTNSVG 666
V W + + L ++ V++ HSG + CQ TN G
Sbjct: 436 -VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 485
Score = 51.2 bits (121), Expect = 4e-06
Identities = 85/375 (22%), Positives = 143/375 (38%), Gaps = 69/375 (18%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK-KQNTFTLN------LREVTKDQS 304
D EG + C+ S PE ++W KDG + + FT+ ++ + +
Sbjct: 2764 DLSTTEGSHAFLPCKARGS-PE-PNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDA 2821
Query: 305 GKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNY 364
G Y C N VG R V L + P +T+ S + G ++ C + +P P
Sbjct: 2822 GTYTCTAENAVGRAR-RRVHLTILVLPVFTTLPGDRSLRL-GDRLWLRCAARGSPTP-RI 2878
Query: 365 TWYHNGKEMQGRTEEK-----VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPP 419
W N + + E+ + + +GTY C AEN +G Q V +
Sbjct: 2879 GWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA-------VSFVH 2931
Query: 420 KKVTTVIQNPM------PIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSL------ 467
K V+Q P+ G ++ L C V R + P W + L
Sbjct: 2932 VKEAPVLQGEAFSYLVEPV--GGSIQLDC--------VVRGDPVPDIHWIKDGLPLRGSH 2981
Query: 468 -------GVLKIQNVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS-E 518
G L I+ D+ C A N V L +Q AP V +++P
Sbjct: 2982 LRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAP----VFQVEPQDMT 3037
Query: 519 IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLN--------FDSISPEDAGSYS 570
+ SG+ V+L+C + ++ W + G+ L +L +++ DAG+Y
Sbjct: 3038 VRSGDDVALRCQATGEPTPTIE--WLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYD 3095
Query: 571 CWVNNSIGQTASKAW 585
C +N +G ++A+
Sbjct: 3096 CVAHNLLGSATARAF 3110
Score = 43.5 bits (101), Expect = 8e-04
Identities = 130/610 (21%), Positives = 208/610 (34%), Gaps = 88/610 (14%)
Query: 103 TLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCL 162
+L + V DSG S+ + L V E PPHI+ + + E++LT
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME---PPHIE---DSGQPTELSLTP- 2227
Query: 163 LNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQ 222
G P++L +G P + + S + G + TC +
Sbjct: 2228 ------GAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAG-LYTCLAE 2280
Query: 223 DADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKD 282
G + ++ V+ P + P + + + C V + ++W +D
Sbjct: 2281 SPAGAI--EKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAP--KITWHRD 2336
Query: 283 GTSLKK-------QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPST 335
G L++ + L L+ ++ SG Y C N G V + E T
Sbjct: 2337 GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS-------TSVAFRVEIHT 2389
Query: 336 VQILHS--PAVEGS--QVEFL-CMSLANPLPTNYTWYHNGKEMQGRT-------EEKVHI 383
V + S PAV S Q L C + P P +W + + R+ E + I
Sbjct: 2390 VPTIRSGPPAVNVSVNQTALLPCQADGVPAPL-VSWRKDRVPLDPRSPRFEILPEGSLRI 2448
Query: 384 PKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCN 443
+L AG Y C+A N G+ ++ G +L V PP + + + + L C
Sbjct: 2449 QPVLAQDAGHYLCLASNSAGSDRQ--GRDLRVLEPPAIAPS--PSNLTLTAHTPALLPCE 2504
Query: 444 YNSSNPSVTRYEWK---------PHGAWE-EPSLGVLKIQNVGWDNTTIACAACNSWCSW 493
S +P WK GA+ PS +L D+ C N
Sbjct: 2505 -ASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEA 2563
Query: 494 ASPVALNVQYAP------RDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNG 547
+ V P D V + P+ + + +S + S Q +G
Sbjct: 2564 HRLYQVTVHVPPTIADDQTDFTVTMMAPV--VLTCHSTGIPAPTVSWSKAGAQLGARGSG 2621
Query: 548 RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVM 607
+ L P AG Y+C NS G A K L V +P + P V+
Sbjct: 2622 YRVSPSGALEIGQALPIHAGRYTCSARNSAG-VAHKHVFLTVQASP-----VVKPLPSVV 2675
Query: 608 EG---KSATLTCESDANPPVSHYTW--------FDWNNQSLPYHSQKLRLEPVKVQHSGA 656
+ L CE+ P + TW + Q LP +LR+ + +G
Sbjct: 2676 RAVAEEEVLLPCEASGIPRPT-ITWQKEGLNVATGVSTQVLP--GGQLRIAHASPEDAGN 2732
Query: 657 YWCQGTNSVG 666
Y C NS G
Sbjct: 2733 YLCIAKNSAG 2742
Score = 38.1 bits (87), Expect = 0.035
Identities = 48/207 (23%), Positives = 70/207 (33%), Gaps = 32/207 (15%)
Query: 491 CSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFF-------- 542
C P+ P +R K +G S++L+CD + E+ +
Sbjct: 2 CRGKEPLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 61
Query: 543 ------------WEKNG--RLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLE 588
W + G RLL + L+F I D+G YSC N G TA + + L
Sbjct: 62 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG-TAQRDFHLL 120
Query: 589 VLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLP--------YH 640
VL P L + + G L C + + P W LP
Sbjct: 121 VLTPPSVLGAGAAQEVLGLAGADVELQCWT-SGVPTPQVEWTKDRQPVLPGGPHLQVQED 179
Query: 641 SQKLRLEPVKVQHSGAYWCQGTNSVGK 667
Q LR+ V G Y C + G+
Sbjct: 180 GQVLRITGSHVGDEGRYQCVAFSPAGQ 206
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 107 bits (267), Expect = 5e-23
Identities = 156/645 (24%), Positives = 251/645 (38%), Gaps = 91/645 (14%)
Query: 86 PSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHI 145
P+ + R F N TL + V++NDSG+ + E+ + + ER PP
Sbjct: 6121 PTPEYRTYFT---NNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSF 6177
Query: 146 QLP-PEIQESQ--EVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRS 202
+I+++ VTLTC LN S PIQ+ W +GV +R TS + +V T
Sbjct: 6178 ARQLKDIEQTVGLPVTLTCRLNGSA---PIQVCWYRDGVLLRDDENLQTSF-VDNVATLK 6233
Query: 203 ELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNV-KHTPKLEIKVTPSDAIVREGDSV 261
L+ SH G+ +C + G S+ + K +P +IK D I G+S
Sbjct: 6234 ILQ--TDLSHSGQY-SCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIA--GESA 6288
Query: 262 TMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT---------LNLREVTKDQSGKYCCQVS 312
C V+ + P ++W KD ++ +T L + +V K SG+Y CQ +
Sbjct: 6289 DFECHVTGAQP--MRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQAT 6346
Query: 313 NDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV--EGSQVEFLCMSLANPLPTNYTWYHNG 370
NDVG + Q+ P V+ L + V +G ++ C +P +W+ N
Sbjct: 6347 NDVG---KDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSP-EIKVSWFRND 6402
Query: 371 KEMQGRTEEKVH---------IPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK 421
E+ + + I + +G Y C A N G G L V+ PP
Sbjct: 6403 SELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHN--GVGDASCSTALTVKAPP-- 6458
Query: 422 VTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRY-----------EWKPHGAWEEPSLGVL 470
V T +P+ +G V L C + + P + ++K + SL +L
Sbjct: 6459 VFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHIL 6518
Query: 471 KIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCD 530
++ D C A N S ++ + PR V+K+ S + G++V L+
Sbjct: 6519 NLE--ASDVGEYHCKATNEVGSDTCSCSVKFKEPPR--FVKKLSDTSTL-IGDAVELRAI 6573
Query: 531 FSSSHPKEVQFFWEKNGRLLGKESQ------------LNFDSISPEDAGSYSCWVNNSIG 578
P + W K+ + +ES+ L S ++G Y C + N G
Sbjct: 6574 VEGFQP--ISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAG 6631
Query: 579 QTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLP 638
A L VL P R+ P V G L C P +S WF + + L
Sbjct: 6632 MRECSA-VLTVL-EPARIIEKPEP-MTVTTGNPFALECVVTGTPELS-AKWFK-DGRELS 6686
Query: 639 YHSQ----------KLRLEPVKVQHSGAYWCQGTNSVGKGRSPLS 673
S+ L++ ++ G Y + NSVGK +S
Sbjct: 6687 ADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVS 6731
Score = 99.0 bits (245), Expect = 2e-20
Identities = 163/641 (25%), Positives = 253/641 (39%), Gaps = 82/641 (12%)
Query: 81 KDGK-VPSEQK-RVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSE 138
KDGK + S+ K ++ F NK L I V +DSG +++ K L VS+
Sbjct: 7621 KDGKELTSDNKYKISFF---NKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSD 7677
Query: 139 RPFPPHIQLPPEIQESQEVT-LTCLLNFSCYGY-PIQLQWLLEGVPMRQAAVTSTSLTIK 196
R PP +++E+ ++ + ++ YG PI + W EG + T+LT
Sbjct: 7678 RTVPP--SFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDN 7735
Query: 197 S-VFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV 255
+ T + L+ S + TC + G + L V+ P K P D +
Sbjct: 7736 TCALTVNMLEESDSGDY-----TCIATNMAGS--DECSAPLTVREPPSFVQKPDPMDVLT 7788
Query: 256 REGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---------KKQNTFTLNLREVTKDQSGK 306
G +VT T V + P +VSW K + L + + L L +V QSG+
Sbjct: 7789 --GTNVTFTSIVKGTPP--FSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGE 7844
Query: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTW 366
Y C VSN+ G S L ++ AP V+ L+ ++E + L + P + TW
Sbjct: 7845 YTCIVSNEAGKA-SCTTHLYIK-AP-AKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTW 7901
Query: 367 YHNG------KEMQGRTEEK---VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQY 417
NG + T EK + IP AG Y+C EN +G+ A++ +
Sbjct: 7902 KKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIEN--ASGKDSCSAQILILE 7959
Query: 418 PPKKVTTVIQNPMPIREGDTVTLSCNY-NSSNPSVTRY----EWKPHGAWE---EPSLGV 469
PP V + P+ + GD+ +L C + V+ Y + +P ++ ++
Sbjct: 7960 PPYFVKQL--EPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVAT 8017
Query: 470 LKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRV-RKIKPLSEIHSGNSVSL 527
L V D+ C A NS ++ L VQ R+++ + E G V
Sbjct: 8018 LVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQET-VGLPVVF 8076
Query: 528 QCDFSSSHPKEVQFFWEKNGR-----------LLGKESQLNFDSISPEDAGSYSCWVNNS 576
C S S P V W K+G+ L + LN AG YSC N
Sbjct: 8077 DCAISGSEPISVS--WYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNP 8134
Query: 577 IGQTASKA-WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQ 635
IG +S A L P + ++P D V+ G+SA C P+ +W + +
Sbjct: 8135 IGSASSSARLILTEGKNPPFFDIRLAPVDAVV-GESADFECHVTGTQPIK-VSWAKDSRE 8192
Query: 636 -------SLPYHSQKLRLEPVKVQ--HSGAYWCQGTNSVGK 667
+ Y L +KV SG Y C N VGK
Sbjct: 8193 IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGK 8233
Score = 98.2 bits (243), Expect = 3e-20
Identities = 159/652 (24%), Positives = 249/652 (38%), Gaps = 104/652 (15%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDGK+ + ++ +F NK +L I V D+G ++++ K ++VS+R
Sbjct: 5739 KDGKLLTSSQKHKF-SFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRA 5797
Query: 141 FPPHIQLPPEIQESQEVT-LTCLLNFSCYG-YPIQLQWLLEGVPMRQAAVTSTSLTIKSV 198
PP ++ + V +C+L G PI + W E + A T+ +
Sbjct: 5798 VPP--SFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFS---- 5851
Query: 199 FTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDT-VQLNVKHTPKLEIKVT-------- 249
+ T QL D + N T V NV + + +T
Sbjct: 5852 ---------------DNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFV 5896
Query: 250 --PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLRE 298
P V G +VT T + + P V+W + L K L L
Sbjct: 5897 KEPEPLEVLPGKNVTFTSVIRGTPP--FKVNWFRGARELVKGDRCNIYFEDTVAELELFN 5954
Query: 299 VTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPST-VQILHSPAVEGSQVEFLCMSLA 357
+ QSG+Y C VSN+ G + EP+ ++ L +VE + L +
Sbjct: 5955 IDISQSGEYTCVVSNNAGQASCTTRL----FVKEPAAFLKRLSDHSVEPGKSIILESTYT 6010
Query: 358 NPLPTNYTWYHNG------KEMQGRTEEKVHIPKIL---PWHAGTYSCVAENILGTGQRG 408
LP + TW +G ++ T EK I +IL AG YSC EN G+
Sbjct: 6011 GTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIEN--EAGRDV 6068
Query: 409 PGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWK---------PH 459
GA + PP VT + P+ GD+V+L C + P +T +K +
Sbjct: 6069 CGALVSTLEPPYFVTEL--EPLEAAVGDSVSLQCQV-AGTPEITVSWYKGDTKLRPTPEY 6125
Query: 460 GAWEEPSLGVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSE 518
+ ++ L V D+ C A NS + +S +Q R + + L +
Sbjct: 6126 RTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQ--ERQLPPSFARQLKD 6183
Query: 519 IHS--GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLN---FDSISP--------ED 565
I G V+L C + S P +Q W ++G LL + L D+++
Sbjct: 6184 IEQTVGLPVTLTCRLNGSAP--IQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSH 6241
Query: 566 AGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSP-GDQVMEGKSATLTCESDANPPV 624
+G YSC +N +G TAS + L + + P V+ G+SA C P+
Sbjct: 6242 SGQYSCSASNPLG-TASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPM 6300
Query: 625 SHYTWFDWNNQSLP---------YHSQKLRLEPVKVQHSGAYWCQGTNSVGK 667
TW N + P ++ LR+ V SG Y CQ TN VGK
Sbjct: 6301 -RITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGK 6351
Score = 95.5 bits (236), Expect = 2e-19
Identities = 158/646 (24%), Positives = 250/646 (38%), Gaps = 91/646 (14%)
Query: 78 ESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVS 137
E TK P+ ++QF KN +L I+ V +D G+ + ++ L +
Sbjct: 7056 EHTKLRSAPAY--KMQF---KNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIK 7110
Query: 138 ERPFPPHIQLP-PEIQESQ--EVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLT 194
R PP ++ E+ V C +N S P+Q+ W +GV ++ A TS
Sbjct: 7111 ARKLPPFFARKLKDVHETLGFPVAFECRINGS---EPLQVSWYKDGVLLKDDANLQTSF- 7166
Query: 195 IKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAI 254
+ +V T L+ SH G+ C + G S+ + L+ P + P
Sbjct: 7167 VHNVATLQILQTDQ--SHIGQY-NCSASNPLGTASSSAKLILSEHEVPPF-FDLKPVSVD 7222
Query: 255 VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLREVTKDQSG 305
+ G+S T C V+ + P ++W KD ++ +NT TL + +V K +G
Sbjct: 7223 LALGESGTFKCHVTGTAP--IKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAG 7280
Query: 306 KYCCQVSNDVGPGRSEEVFLQVQYAP------EPSTVQILHSPAVEGSQVEFLCMSLANP 359
+Y C SN G S L VQ P EPS + + + C +P
Sbjct: 7281 QYTCYASNIAGKD-SCSAQLGVQEPPRFIKKLEPSRI------VKQDEFTRYECKIGGSP 7333
Query: 360 LPTNYTWYHNGKEMQGRTEEK---VHIPKILPWH------AGTYSCVAENILGTGQRGPG 410
WY + E+Q ++ + V +L H +G Y+C A N G
Sbjct: 7334 -EIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHN--AAGSASSS 7390
Query: 411 AELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNP-SVTRYE-------WKPHGAW 462
L V+ PP + +P+ +G V L C + P V+ Y+ K +
Sbjct: 7391 TSLKVKEPP--IFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIM 7448
Query: 463 EEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521
E L + I NV D C A N S ++ ++ PR V+K+ +S +
Sbjct: 7449 SENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPR--FVKKLSDISTV-V 7505
Query: 522 GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKE-----------SQLNFDSISPEDAGSYS 570
G V LQ + P V +F +K G ++ + + L F + P +AG Y+
Sbjct: 7506 GKEVQLQTTIEGAEPISVVWFKDK-GEIVRESDNIWISYSENIATLQFSRVEPANAGKYT 7564
Query: 571 CWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWF 630
C + N G A TL VL P + V +V G + TL C P +S WF
Sbjct: 7565 CQIKNDAGMQECFA-TLSVL-EPATI-VEKPESIKVTTGDTCTLECTVAGTPELS-TKWF 7620
Query: 631 DWNNQSLPYHSQK---------LRLEPVKVQHSGAYWCQGTNSVGK 667
+ + K L++ V SG Y + N VGK
Sbjct: 7621 KDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGK 7666
Score = 91.7 bits (226), Expect = 3e-18
Identities = 141/631 (22%), Positives = 241/631 (38%), Gaps = 78/631 (12%)
Query: 102 CTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTC 161
CTL ++ + +D G + R L V E P P E+ + VT T
Sbjct: 5855 CTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTS 5914
Query: 162 LLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELK-FSPQWSHHGKIVTCQ 220
++ + P ++ W + V I T +EL+ F+ S G+ TC
Sbjct: 5915 VIRGTP---PFKVNWFRGA----RELVKGDRCNIYFEDTVAELELFNIDISQSGEY-TCV 5966
Query: 221 LQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWL 280
+ + G+ ++ T +L VK ++ SD V G S+ + + + P +V+W
Sbjct: 5967 VSNNAGQ--ASCTTRLFVKEPAAFLKRL--SDHSVEPGKSIILESTYTGTLP--ISVTWK 6020
Query: 281 KDG---TSLKKQNTFT------LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP 331
KDG T+ +K N T L + TK +G+Y C++ N+ GR L P
Sbjct: 6021 KDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEA--GRDVCGALVSTLEP 6078
Query: 332 EPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIP------- 384
++ A G V C P T +WY +++ E + +
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGTPEIT-VSWYKGDTKLRPTPEYRTYFTNNVATLV 6137
Query: 385 --KILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSC 442
K+ +G Y+C AEN +GT + + P +++ + G VTL+C
Sbjct: 6138 FNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKD-IEQTVGLPVTLTC 6196
Query: 443 NYNSSNPSVTRYEWKPHGAW--EEPSLGVLKIQNVGW---------DNTTIACAACNSWC 491
N S P + W G ++ +L + NV + +C+A N
Sbjct: 6197 RLNGSAP--IQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLG 6254
Query: 492 SWASPVALNVQYAPRDVRVRKIKPLS-EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR-- 548
+ +S L + P+ IKP+S ++ +G S +C + + P + W K+ +
Sbjct: 6255 TASSSARLTAR-EPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRIT--WSKDNKEI 6311
Query: 549 ---------LLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVS 599
+G L + D+G Y+C N +G+ A L V P+ ++
Sbjct: 6312 RPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSA-QLSVKEPPKFVK-K 6369
Query: 600 MSPGDQVMEGKSATLTCESDANPPVSHYTWF--------DWN-NQSLPYHSQKLRLEPVK 650
+ +G+S L C+ +P + +WF W N S L +
Sbjct: 6370 LEASKVAKQGESIQLECKISGSPEIK-VSWFRNDSELHESWKYNMSFINSVALLTINEAS 6428
Query: 651 VQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
+ SG Y C+ N VG S + LTV P
Sbjct: 6429 AEDSGDYICEAHNGVGDA-SCSTALTVKAPP 6458
Score = 91.7 bits (226), Expect = 3e-18
Identities = 99/398 (24%), Positives = 168/398 (42%), Gaps = 49/398 (12%)
Query: 98 KNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEV 157
+N TL + V +NDSG+ + E+ + L V E+ PP ++++ QE
Sbjct: 8012 RNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPP--SFSRQLRDVQE- 8068
Query: 158 TLTCLLNFSCY---GYPIQLQWLLEGVPMRQAAVTSTSL---TIKSVFTRSELKFSPQWS 211
T+ + F C PI + W +G P++ + TS T +++ + Q+S
Sbjct: 8069 TVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYS 8128
Query: 212 HHGKIVTCQLQDADGKFLSNDTVQLNV-KHTPKLEIKVTPSDAIVREGDSVTMTCEVSSS 270
C + G S+ + L K+ P +I++ P DA+V G+S C V+ +
Sbjct: 8129 -------CTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV--GESADFECHVTGT 8179
Query: 271 NPEYTTVSWLKDGTSLKK---------QNTFTLNLREVTKDQSGKYCCQVSNDVGPGR-S 320
P VSW KD ++ +N+ L + +V K SG+Y C N+VG +
Sbjct: 8180 QP--IKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCT 8237
Query: 321 EEVFLQVQYAPEPSTVQILHS-PAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEE 379
++ ++ + P T ++ + EG+ + L +A P WY N E+Q +
Sbjct: 8238 AQLNIKERLIPPSFTKRLSETVEETEGNSFK-LEGRVAGSQPITVAWYKNNIEIQPTSNC 8296
Query: 380 KV---------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQN-- 428
++ + K AG Y+C N G+ V PKK Q+
Sbjct: 8297 EITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSI---VIKEPKKPPVFDQHLT 8353
Query: 429 PMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPS 466
P+ + EG+ V LSC+ S P R +W G +PS
Sbjct: 8354 PVTVSEGEYVQLSCHVQGSEP--IRIQWLKAGREIKPS 8389
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/559 (23%), Positives = 211/559 (37%), Gaps = 97/559 (17%)
Query: 172 IQLQWLLEGVPMR-----QAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADG 226
I +W +G + + +VT T +K + T E K S ++ T ++Q+ G
Sbjct: 4608 ITAKWFKDGQELTLGSKYKISVTDTVSILKIIST--EKKDSGEY-------TFEVQNDVG 4658
Query: 227 KFLSNDTVQLNVKHT---PKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDG 283
+ S+ ++NV P K+ D+I +G + + C V+ S+P ++ W KD
Sbjct: 4659 R--SSCKARINVLDLIIPPSFTKKLKKMDSI--KGSFIDLECIVAGSHP--ISIQWFKDD 4712
Query: 284 TSLKKQ---------NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPS 334
+ NT L + ++ SG Y C +N G + + P
Sbjct: 4713 QEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSG---HLTVKEPPY 4769
Query: 335 TVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGR---------TEEKVHIPK 385
V+ S V + L + P W+ + KE+ T + +
Sbjct: 4770 FVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFA 4829
Query: 386 ILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPI---REGDTVTLSC 442
+GTY C N +GT A L V+ PP+ I+ P P+ R G + T C
Sbjct: 4830 AKATDSGTYICQLSNDVGTATSK--ATLFVKEPPQ----FIKKPSPVLVLRNGQSTTFEC 4883
Query: 443 NYNSSNPSVTRYEW----------KPHGAWEEPSLGVLKIQNVGWDNT-TIACAACNSWC 491
+ P + R W + HG L +I +N+ T C A N
Sbjct: 4884 QITGT-PKI-RVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAG 4941
Query: 492 SWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG 551
+ + + L V+ P +R++KP+ E+ + V L+C+ + + P EV W KN R +
Sbjct: 4942 TASCSIELKVKEPP--TFIRELKPV-EVVKYSDVELECEVTGTPPFEVT--WLKNNREIR 4996
Query: 552 KESQ-----------LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM 600
+ L+ P D G Y C V+N G + T L P +
Sbjct: 4997 SSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCS--TRVALKEPPSFIKKI 5054
Query: 601 SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQ----------KLRLEPVK 650
V++ SAT +PP+S TW ++Q L L++ V
Sbjct: 5055 ENTTTVLKS-SATFQSTVAGSPPIS-ITWLK-DDQILDEDDNVYISFVDSVATLQIRSVD 5111
Query: 651 VQHSGAYWCQGTNSVGKGR 669
HSG Y CQ N G R
Sbjct: 5112 NGHSGRYTCQAKNESGVER 5130
Score = 79.7 bits (195), Expect = 1e-14
Identities = 136/582 (23%), Positives = 223/582 (38%), Gaps = 92/582 (15%)
Query: 150 EIQESQEVTL--TCLLNFSCYGYP-IQLQWLLEGVPMRQAAVTSTSLTIKSVFTR-SELK 205
E ES +VT TC L + G P + +W +G + TS + S F + S LK
Sbjct: 7590 EKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL-----TSDNKYKISFFNKVSGLK 7644
Query: 206 FSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTP-KLEIKVTPSDAIVREGDSVTMT 264
+ + ++Q+ GK ++Q++ + P K+ ++ + G SV M
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL--SGSSVVME 7702
Query: 265 CEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLREVTKDQSGKYCCQVSNDV 315
C+V S P +VSW +G + NT L + + + SG Y C +N
Sbjct: 7703 CKVYGSPP--ISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMA 7760
Query: 316 GPGRSEEVFLQVQYAPEPSTVQILHSPAV-EGSQVEFLCMSLANPLPTNYTWYHNGKEMQ 374
G S+E + PS VQ V G+ V F + P P + +W+ E+
Sbjct: 7761 G---SDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTP-PFSVSWFKGSSELV 7816
Query: 375 GRTEEKVHIPKILPW---------HAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTV 425
V + + +G Y+C+ N G+ L ++ P K V +
Sbjct: 7817 PGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSN--EAGKASCTTHLYIKAPAKFVKRL 7874
Query: 426 IQNPMPIREGDTVTLSCNYNSSNP-SVTRYEWKPHGAWEEPSL----------GVLKI-- 472
N I +G + L + + P SVT WK +G PS +L+I
Sbjct: 7875 --NDYSIEKGKPLILEGTFTGTPPISVT---WKKNGINVTPSQRCNITTTEKSAILEIPS 7929
Query: 473 ---QNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQC 529
++ G N I A+ CS A + L Y V++++P+ ++ G+S SLQC
Sbjct: 7930 STVEDAGQYNCYIENASGKDSCS-AQILILEPPYF-----VKQLEPV-KVSVGDSASLQC 7982
Query: 530 DFSSSHPKEVQFFWEKNGRLL-----------GKESQLNFDSISPEDAGSYSCWVNNSIG 578
+ + E+ W K L + L F+ + D+G Y C NS+G
Sbjct: 7983 QLAGT--PEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVG 8040
Query: 579 Q-TASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWF------- 630
+ +AS T++ P + + + G C + P+S +W+
Sbjct: 8041 EVSASTFLTVQEQKLPPSFSRQLRDVQETV-GLPVVFDCAISGSEPIS-VSWYKDGKPLK 8098
Query: 631 DWNNQSLPYHSQKLRLEPVKVQHS--GAYWCQGTNSVGKGRS 670
D N + L K S G Y C TN +G S
Sbjct: 8099 DSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASS 8140
Score = 79.3 bits (194), Expect = 1e-14
Identities = 133/639 (20%), Positives = 240/639 (37%), Gaps = 85/639 (13%)
Query: 81 KDGK--VPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSE 138
KDGK S++ R+ F+ +L I V +ND+G R + L V E
Sbjct: 4148 KDGKEIAASDRYRIAFV---EGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQE 4204
Query: 139 RPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSV 198
PP P ++ + CL + P+ ++W + V+ S I
Sbjct: 4205 ---PPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKEL----VSGGSCYITKE 4257
Query: 199 FTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREG 258
S L+ + TC++ + G + L VK K+ PS ++++G
Sbjct: 4258 ALESSLELYLVKTSDSGTYTCKVSNVAGGV--ECSANLFVKEPATFVEKLEPSQ-LLKKG 4314
Query: 259 DSVTMTCEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLREVTKDQSGKYCC 309
D+ + C+V+ + P ++W + +K+ ++T L L +V + SG+Y C
Sbjct: 4315 DATQLACKVTGTPP--IKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMC 4372
Query: 310 QVSNDVGPGRSEEVFLQVQ---YAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTW 366
+ N+ G + + + + E +++L V L +A P TW
Sbjct: 4373 EAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDV------MLLAEVAGTPPFEITW 4426
Query: 367 YHNGKEMQGRTEEK---------VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQY 417
+ + ++ + K + I K + AG Y C N +G+ A + ++
Sbjct: 4427 FKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSI--CSARVTLRE 4484
Query: 418 PPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVG- 476
PP + I++ +R G T S P + E+ ++ + NV
Sbjct: 4485 PPSFIKK-IESTSSLR-GGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVAS 4542
Query: 477 --------WDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQ 528
+ C A N L+V+ P + + ++ G+ +LQ
Sbjct: 4543 LYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK-EPATITEEAVS--IDVTQGDPATLQ 4599
Query: 529 CDFSSSHPKEVQFFWEKNGR--LLGKE---------SQLNFDSISPEDAGSYSCWVNNSI 577
FS + KE+ W K+G+ LG + S L S +D+G Y+ V N +
Sbjct: 4600 VKFSGT--KEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDV 4657
Query: 578 GQTASKA-WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQ- 635
G+++ KA + L P + D + +G L C + P+S WF + +
Sbjct: 4658 GRSSCKARINVLDLIIPPSFTKKLKKMDSI-KGSFIDLECIVAGSHPIS-IQWFKDDQEI 4715
Query: 636 ------SLPYHSQKLRLEPVKVQ--HSGAYWCQGTNSVG 666
+H LE +++ SG Y C TN G
Sbjct: 4716 SASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754
Score = 79.3 bits (194), Expect = 1e-14
Identities = 151/652 (23%), Positives = 243/652 (37%), Gaps = 108/652 (16%)
Query: 81 KDGK--VPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSE 138
KDGK VPS + F +N + I V DSGQ ++E+ +L V +
Sbjct: 5176 KDGKQIVPSRYFSMSF---ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLD 5232
Query: 139 RPFPPHIQLPPEIQESQEVTLTCLLNFSCY---GYPIQLQWLLEGVPMRQAAV------- 188
+ PP ++ + +V L ++ C PI QW +G + +A
Sbjct: 5233 QNIPP--SFTKKLTKMDKV-LGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHE 5289
Query: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
S SL + ++ EL+ + + TC++ + G + L VK P +K
Sbjct: 5290 RSVSLEVNNL----ELEDTANY-------TCKVSNVAGDDACSGI--LTVKEPPSFLVKP 5336
Query: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK---------KQNTFTLNLREV 299
AI DS + P + + W KD L + +T LNL V
Sbjct: 5337 GRQQAIP---DSTVEFKAILKGTPPFK-IKWFKDDVELVSGPKCFIGLEGSTSFLNLYSV 5392
Query: 300 TKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANP 359
++G+Y C V+NDVG + L + P ++ S V+ L +A
Sbjct: 5393 DASKTGQYTCHVTNDVGSDSCTTMLLVTE--PPKFVKKLEASKIVKAGDSSRLECKIAGS 5450
Query: 360 LPTNYTWYHNGKEMQGRTEEK---------VHIPKILPWHAGTYSCVAENILGTGQRGPG 410
W+ N E+ + + + + + +G + C A+N G
Sbjct: 5451 PEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQN--PAGSTSCS 5508
Query: 411 AELDVQYPPKKVTTVIQNPMPIRE---GDTVTLSCNYNSSNP-SVTRY----------EW 456
++ V+ PP V + PI E V+L C + + P V Y ++
Sbjct: 5509 TKVIVKEPP-----VFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKY 5563
Query: 457 KPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPL 516
K S+ +L + D C A N S + ++ PR V K+ L
Sbjct: 5564 KIASKNFHTSIHILNVDTS--DIGEYHCKAQNEVGSDTCVCTVKLKEPPR--FVSKLNSL 5619
Query: 517 SEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKE----------SQLNFDSISPEDA 566
+ + +G LQ + P VQ+ EK + E + L F P +A
Sbjct: 5620 TVV-AGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANA 5678
Query: 567 GSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSH 626
G Y C + N G + A TL VL + V + V G++ TL C+ P +S
Sbjct: 5679 GKYICQIKNDGGMRENMA-TLMVL--EPAVIVEKAGPMTVTVGETCTLECKVAGTPELS- 5734
Query: 627 YTWFDWNNQSLPYHSQK-----------LRLEPVKVQHSGAYWCQGTNSVGK 667
W+ + L SQK LR+ V+ Q +G Y Q N+VGK
Sbjct: 5735 VEWY--KDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGK 5784
Score = 77.0 bits (188), Expect = 7e-14
Identities = 135/618 (21%), Positives = 221/618 (35%), Gaps = 88/618 (14%)
Query: 104 LSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQE---VTLT 160
L I DSG+ +++ + + +NV + PP + +S + + L
Sbjct: 4636 LKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLE 4695
Query: 161 CLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQ 220
C++ S +PI +QW + + + S + F L+ S TC
Sbjct: 4696 CIVAGS---HPISIQWFKDDQEISASEKYKFSFHDNTAF----LEISQLEGTDSGTYTCS 4748
Query: 221 LQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWL 280
+ G + + L VK P K P V V + V + P T+ W
Sbjct: 4749 ATNKAGH--NQCSGHLTVKEPPYFVEK--PQSQDVNPNTRVQLKALVGGTAP--MTIKWF 4802
Query: 281 KDGTSL---------KKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFL---QVQ 328
KD L K + +L L SG Y CQ+SNDVG S+ Q
Sbjct: 4803 KDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQ 4862
Query: 329 YAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV------- 381
+ +PS V +L + G F C P +WY +G E+ + +
Sbjct: 4863 FIKKPSPVLVLRN----GQSTTFECQITGTP-KIRVSWYLDGNEITAIQKHGISFIDGLA 4917
Query: 382 --HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVT 439
I ++GTY C A N GT EL V+ PP + + P+ + + V
Sbjct: 4918 TFQISGARVENSGTYVCEARNDAGTA--SCSIELKVKEPPTFIREL--KPVEVVKYSDVE 4973
Query: 440 LSCNYNSSNPSVTRY--------EWKPHGAWEEPSLGVLKIQNVGWDNT-TIACAACNSW 490
L C + P + K + + S+ L I +T C N
Sbjct: 4974 LECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEG 5033
Query: 491 --CSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR 548
CS ++ VAL + ++KI+ + + +S + Q + S P + W K+ +
Sbjct: 5034 GSCSCSTRVALKEPPS----FIKKIENTTTVLK-SSATFQSTVAGSPP--ISITWLKDDQ 5086
Query: 549 LLGKE-----------SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLR 597
+L ++ + L S+ +G Y+C N G + + ++ P ++
Sbjct: 5087 ILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESG--VERCYAFLLVQEPAQI- 5143
Query: 598 VSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLP--YHSQ-------KLRLEP 648
V + V E TL C A P W Q +P Y S R++
Sbjct: 5144 VEKAKSVDVTEKDPMTLECVV-AGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQS 5202
Query: 649 VKVQHSGAYWCQGTNSVG 666
V Q SG Y + N G
Sbjct: 5203 VMKQDSGQYTFKVENDFG 5220
Score = 77.0 bits (188), Expect = 7e-14
Identities = 128/633 (20%), Positives = 228/633 (36%), Gaps = 83/633 (13%)
Query: 100 KNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTL 159
K+ L I + D+GQ +E+ + K + + E P+ P ++ +L
Sbjct: 7921 KSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASL 7980
Query: 160 TCLLNFSCYGYP-IQLQWLLEGVPMRQAAVTSTSL---TIKSVFTRSELKFSPQWSHHGK 215
C L G P I + W +R VF + ++ S ++
Sbjct: 7981 QCQLA----GTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEY----- 8031
Query: 216 IVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYT 275
C+ +++ G+ ++ + + + P D G V C +S S P
Sbjct: 8032 --ICKAENSVGEVSASTFLTVQEQKLPP-SFSRQLRDVQETVGLPVVFDCAISGSEP--I 8086
Query: 276 TVSWLKDGTSLKKQ---------NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQ 326
+VSW KDG LK NT TLN+ + + +G+Y C +N +G S +
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLIL 8146
Query: 327 VQYAPEPS-TVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGR-------TE 378
+ P +++ AV G +F C + P +W + +E++ E
Sbjct: 8147 TEGKNPPFFDIRLAPVDAVVGESADFEC-HVTGTQPIKVSWAKDSREIRSGGKYQISYLE 8205
Query: 379 EKVHIP--KILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGD 436
H+ K+ +G Y+C A N +G + + P T + + EG+
Sbjct: 8206 NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGN 8265
Query: 437 TVTLSCNYNSSNPSVTRY-----EWKPHGAWE---EPSLGVLKIQNVGWDNTTIACAACN 488
+ L S P + E +P E + + VL+++ G ++ + +
Sbjct: 8266 SFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVS 8325
Query: 489 SWCSWASPVALNVQYAPRDVRV--RKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKN 546
+ A + V P+ V + + P++ + G V L C S P +Q W K
Sbjct: 8326 NDAGSALCTSSIVIKEPKKPPVFDQHLTPVT-VSEGEYVQLSCHVQGSEPIRIQ--WLKA 8382
Query: 547 GRLLGKESQLNFD-----------SISPEDAGSYSCWVNNSIGQTASKA----------- 584
GR + + +F ++ D+G Y C +N G +K+
Sbjct: 8383 GREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVA 8442
Query: 585 -WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYT---WFDWNNQSLPY 639
T + R VS +V+E +AT + +P P +T W N +
Sbjct: 8443 PATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVF 8502
Query: 640 HSQ-----KLRLEPVKVQHSGAYWCQGTNSVGK 667
Q KL + SG Y C N G+
Sbjct: 8503 IHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGE 8535
Score = 74.7 bits (182), Expect = 3e-13
Identities = 153/651 (23%), Positives = 241/651 (37%), Gaps = 102/651 (15%)
Query: 81 KDGKVPSEQKR--VQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSE 138
KDG+ S + + F+ NK +L I ++D G +++ K + ++VS+
Sbjct: 6680 KDGRELSADSKHHITFI---NKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSD 6736
Query: 139 RPFPPH-IQLPPEIQE--SQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTI 195
R PP I+ ++ V L C ++ S PI + W +G + +S +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVLECRVSGSA---PISVGWFQDGNEIVSGPKCQSSFS- 6792
Query: 196 KSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV 255
++V T + P S G I TC + G + L V+ P E TP V
Sbjct: 6793 ENVCTLNLSLLEP--SDTG-IYTCVAANVAGS--DECSAVLTVQEPPSFE--QTPDSVEV 6845
Query: 256 REGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLR---------EVTKDQSGK 306
G S+T T + + P V W K L + ++L EV +SG
Sbjct: 6846 LPGMSLTFTSVIRGTPP--FKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGD 6903
Query: 307 YCCQVSNDVGPGRSEEVFLQVQYAPEPST-VQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
Y C V+ND G + EP+T V+ L +VE L + P + +
Sbjct: 6904 YSCLVTNDAGSASCTTHL----FVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVS 6959
Query: 366 WYHN------GKEMQGRTEEKVHIPKILP---WHAGTYSCVAENILGTGQRGPGAELDVQ 416
W + + EK I +IL YSC+ EN GQ A + V
Sbjct: 6960 WIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIEN--EAGQDICEALVSVL 7017
Query: 417 YPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEE------------ 464
PP + + I G+ TL C + + P + +K H
Sbjct: 7018 EPPYFIEPLEHVEAVI--GEPATLQCKVDGT-PEIRISWYKEHTKLRSAPAYKMQFKNNV 7074
Query: 465 PSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKP-----LSEI 519
SL + K+ + D +C A NS + AS L ++ RK+ P L ++
Sbjct: 7075 ASLVINKVDHS--DVGEYSCKADNSVGAVASSAVL-------VIKARKLPPFFARKLKDV 7125
Query: 520 HS--GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSI-----------SPEDA 566
H G V+ +C + S P +V W K+G LL ++ L +
Sbjct: 7126 HETLGFPVAFECRINGSEPLQVS--WYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHI 7183
Query: 567 GSYSCWVNNSIGQTASKA-WTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVS 625
G Y+C +N +G +S A L P + D + G+S T C P+
Sbjct: 7184 GQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLAL-GESGTFKCHVTGTAPIK 7242
Query: 626 HYTWFDWNNQSLPYHSQKLRLE---------PVKVQHSGAYWCQGTNSVGK 667
TW N + P + K+ L V +G Y C +N GK
Sbjct: 7243 -ITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGK 7292
Score = 73.6 bits (179), Expect = 7e-13
Identities = 103/463 (22%), Positives = 165/463 (35%), Gaps = 69/463 (14%)
Query: 255 VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK---------KQNTFTLNLREVTKDQSG 305
V GD T+ V+ + PE W KDG L K N L SG
Sbjct: 4028 VTAGDPATLEYTVAGT-PELKP-KWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSG 4085
Query: 306 KYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
+Y ++SN+VG E F + P + L + + L +A LP +
Sbjct: 4086 QYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVS 4145
Query: 366 WYHNGKEMQGRTEEKV---------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQ 416
W+ +GKE+ ++ I ++ AG ++C A N +G+ + L VQ
Sbjct: 4146 WFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGS--KDSSGALIVQ 4203
Query: 417 YPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRY-----EWKPHGAWE------EP 465
PP VT + G V L + S P R+ E G+ E
Sbjct: 4204 EPPSFVTK--PGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALES 4261
Query: 466 SLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSV 525
SL + ++ D+ T C N + + N+ V K++P + G++
Sbjct: 4262 SLELYLVKTS--DSGTYTCKVSN--VAGGVECSANLFVKEPATFVEKLEPSQLLKKGDAT 4317
Query: 526 SLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-----------LNFDSISPEDAGSYSCWVN 574
L C + + P ++ W N R + + S+ L + ED+G Y C
Sbjct: 4318 QLACKVTGTPP--IKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQ 4375
Query: 575 NSIGQTASKAWTL--EVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDW 632
N G + + E Y + + +V++ L E PP TWF
Sbjct: 4376 NEAGSDHCSSIVIVKESPYFTKEFKPI-----EVLKEYDVMLLAEVAGTPPFE-ITWFKD 4429
Query: 633 NN---------QSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG 666
N + H L++ +G Y C+ TN VG
Sbjct: 4430 NTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVG 4472
Score = 73.2 bits (178), Expect = 1e-12
Identities = 113/481 (23%), Positives = 183/481 (38%), Gaps = 73/481 (15%)
Query: 238 VKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLN-- 295
+K P KV D I G +VT+ V S P +V+W+K +++ ++
Sbjct: 3920 LKEPPTFVKKV--DDLIALGGQTVTLQAAVRGSEP--ISVTWMKGQEVIREDGKIKMSFS 3975
Query: 296 -------LREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQ 348
+ +V GKY C N+ G S + + A +++ A + +
Sbjct: 3976 NGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPAT 4035
Query: 349 VEFLCMSLANPLPTNYTWYHNGKEMQG----RTEEKVHIPKILPWHA-----GTYSCVAE 399
+E+ P WY +G+ + R K ++ ++ + A G Y+
Sbjct: 4036 LEYTVAGTPELKPK---WYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEIS 4092
Query: 400 NILGTGQ-RGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
N +G+ LD P T ++N + G T L C S P R W
Sbjct: 4093 NEVGSSSCETTFTVLDRDIAPF-FTKPLRNVDSVVNG-TCRLDCKIAGSLPM--RVSWFK 4148
Query: 459 HG-----------AWEE--PSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAP 505
G A+ E SL ++++ N T C A NS S S AL VQ P
Sbjct: 4149 DGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFT--CRATNSVGSKDSSGALIVQEPP 4206
Query: 506 RDVRVRKIKPLS-EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGK---------ESQ 555
V KP S ++ G++V L+ F S P +++F + G ES
Sbjct: 4207 SFVT----KPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESS 4262
Query: 556 LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLT 615
L + D+G+Y+C V+N G A + P + P + +G + L
Sbjct: 4263 LELYLVKTSDSGTYTCKVSNVAGGVECSANLF--VKEPATFVEKLEPSQLLKKGDATQLA 4320
Query: 616 CESDANPPVSHYTWFDWNNQSLPYHSQK----------LRLEPVKVQHSGAYWCQGTNSV 665
C+ PP+ TWF N++ + S+ LRL V ++ SG Y C+ N
Sbjct: 4321 CKVTGTPPIK-ITWFA-NDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEA 4378
Query: 666 G 666
G
Sbjct: 4379 G 4379
Score = 72.4 bits (176), Expect = 2e-12
Identities = 119/538 (22%), Positives = 198/538 (36%), Gaps = 99/538 (18%)
Query: 226 GKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKD--- 282
G+ S+ T+ +N P++ ++ P + + C V S P+ +SW K+
Sbjct: 3223 GRNRSSVTLYVNAPEPPQVLQELQP---VTVQSGKPARFCAVISGRPQ-PKISWYKEEQL 3278
Query: 283 -GTSLKKQ-----NTFTLNLREVTKDQSGKYCCQVSNDVGPG-RSEEVFLQVQYAPEPST 335
T K + +TL L E + + Y C+ ND G S + ++V P
Sbjct: 3279 LSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQ 3338
Query: 336 VQILHSPAV----------EGSQVEFLCMSLANPLPTNYTWYHNGKEM---------QGR 376
++ PA+ EG F C L +WY K++ Q
Sbjct: 3339 EMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL--KVSWYSKDKKIKPSRFFRMTQFE 3396
Query: 377 TEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK--------------KV 422
++ I + P GTY+ VA N GQ A L ++ P K
Sbjct: 3397 DTYQLEIAEAYPEDEGTYTFVASN--AVGQVSSTANLSLEAPESILHERIEQEIEMEMKA 3454
Query: 423 TTVIQ---NPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG--AWEE-----------PS 466
VI+ P+ + G +C S+ P+V R++W G +E S
Sbjct: 3455 APVIKRKIEPLEVALGHLAKFTCEIQSA-PNV-RFQWFKAGREIYESDKCSIRSSKYISS 3512
Query: 467 LGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVS 526
L +L+ Q V D C A N + S + L V A + + K L+ G +
Sbjct: 3513 LEILRTQVV--DCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTF-VGKAAK 3569
Query: 527 LQCDFSSSHPKEVQFFWEKNGRLLGKESQ-----------LNFDSISPEDAGSYSCWVNN 575
C + + ++ W+K+G L L +++ +D G YSC +N
Sbjct: 3570 FICTVTGT--PVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASN 3627
Query: 576 SIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQ 635
G +A L ++ P ++ + P + K L C+ D + V+ TW +
Sbjct: 3628 KFGADICQA-ELIIIDKPHFIK-ELEPVQSAI-NKKVHLECQVDEDRKVT-VTWSKDGQK 3683
Query: 636 SLPYHSQKLRLEP---------VKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETI 684
P K+ E K++ SG Y C +N G S +T+TV P +
Sbjct: 3684 LPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSS-SCSATVTVREPPSFV 3740
Score = 72.4 bits (176), Expect = 2e-12
Identities = 105/481 (21%), Positives = 170/481 (35%), Gaps = 64/481 (13%)
Query: 234 VQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT 293
+++ +K P ++ K+ P + + G TCE+ S+ W K G + + + +
Sbjct: 3448 IEMEMKAAPVIKRKIEPLEVAL--GHLAKFTCEIQSA--PNVRFQWFKAGREIYESDKCS 3503
Query: 294 LNLR------EVTKDQ---SGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV 344
+ E+ + Q G+Y C+ SN+ G + P +
Sbjct: 3504 IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTF 3563
Query: 345 EGSQVEFLCMSLANPLPTNYTWYHNGKEMQ---------GRTEEKVHIPKILPWHAGTYS 395
G +F+C P+ W +G + + + + + G YS
Sbjct: 3564 VGKAAKFICTVTGTPV-IETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYS 3622
Query: 396 CVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYE 455
C A N G AEL + P + + P+ V L C + +
Sbjct: 3623 CKASNKFGADICQ--AELIIIDKPHFIKEL--EPVQSAINKKVHLECQVDEDRKVTVTWS 3678
Query: 456 --------WKPHGAWEEPSLGVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPR 506
K + E + L+I D+ T C A N S + + V+ P
Sbjct: 3679 KDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPS 3738
Query: 507 DVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGK-----------ESQ 555
V+ K+ P + G S L C S +Q W KN + L + E+
Sbjct: 3739 FVK--KVDPSYLMLPGESARLHCKLKGS--PVIQVTWFKNNKELSESNTVRMYFVNSEAI 3794
Query: 556 LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLT 615
L+ + ED+GSYSC N +G + T V+ P ++ P D ++ G +A L
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCS--TEIVIKEPPSFIKTLEPAD-IVRGTNALLQ 3851
Query: 616 CESDANPPVSHYTWFDWNNQ---SLPYH--SQK----LRLEPVKVQHSGAYWCQGTNSVG 666
CE P +WF Q S Y SQK L + G Y C N VG
Sbjct: 3852 CEVSGTGPF-EISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Query: 667 K 667
K
Sbjct: 3911 K 3911
Score = 71.6 bits (174), Expect = 3e-12
Identities = 111/488 (22%), Positives = 196/488 (40%), Gaps = 71/488 (14%)
Query: 230 SNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQ 289
S+ + + V+ P KV PS ++ G+S + C++ S V+W K+ L +
Sbjct: 3725 SSCSATVTVREPPSFVKKVDPS-YLMLPGESARLHCKLKGS--PVIQVTWFKNNKELSES 3781
Query: 290 NTFT---------LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILH 340
NT L++ +V + SG Y C+ NDVG S+ ++ PS ++ L
Sbjct: 3782 NTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVG---SDSCSTEIVIKEPPSFIKTLE 3838
Query: 341 SPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKIL---------PWHA 391
+ L ++ P +W+ + K+++ + ++ K L
Sbjct: 3839 PADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADV 3898
Query: 392 GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNP-- 449
G Y CV N G+ G A ++ PP V V + + G TVTL S P
Sbjct: 3899 GEYECVVAN--EVGKCGCMATHLLKEPPTFVKKV--DDLIALGGQTVTLQAAVRGSEPIS 3954
Query: 450 -------SVTRYEWKPHGAWEEPSLGVLKIQNVGWD-NTTIACAACNSWCSWASPVALNV 501
V R + K ++ + VL I +V C A N S S L V
Sbjct: 3955 VTWMKGQEVIREDGKIKMSFSN-GVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIV 4013
Query: 502 QYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL----------- 550
+ ++ + L ++ +G+ +L +++ + E++ W K+GR L
Sbjct: 4014 K---EPAKIIERAELIQVTAGDPATL--EYTVAGTPELKPKWYKDGRPLVASKKYRISFK 4068
Query: 551 GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVL---YAPRRLRVSMSPGDQVM 607
+QL F S D+G Y+ ++N +G ++ + T VL AP + + D V+
Sbjct: 4069 NNVAQLKFYSAELHDSGQYTFEISNEVGSSSCET-TFTVLDRDIAPFFTK-PLRNVDSVV 4126
Query: 608 EGKSATLTCESDANPPVSHYTWF---------DWNNQSLPYHSQKLRLEPVKVQHSGAYW 658
G + L C+ + P+ +WF D + + L + V + +G +
Sbjct: 4127 NG-TCRLDCKIAGSLPM-RVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFT 4184
Query: 659 CQGTNSVG 666
C+ TNSVG
Sbjct: 4185 CRATNSVG 4192
Score = 70.9 bits (172), Expect = 5e-12
Identities = 113/506 (22%), Positives = 196/506 (38%), Gaps = 84/506 (16%)
Query: 227 KFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYT----------- 275
KF++ D + + T ++ + + +RE S E +SS T
Sbjct: 4454 KFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSL 4513
Query: 276 --TVSWLKDGTSLKKQ---------NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVF 324
TV+WLKD + + N +L L + GKY CQ ND G R
Sbjct: 4514 PITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRC-SAL 4572
Query: 325 LQVQYAPEPSTV--QILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK-- 380
L V+ EP+T+ + + +G L + + W+ +G+E+ ++ K
Sbjct: 4573 LSVK---EPATITEEAVSIDVTQGDPAT-LQVKFSGTKEITAKWFKDGQELTLGSKYKIS 4628
Query: 381 ----VHIPKILPWH---AGTYSCVAENILGTGQ-RGPGAELDVQYPPKKVTTVIQNPMPI 432
V I KI+ +G Y+ +N +G + LD+ PP T M
Sbjct: 4629 VTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPS--FTKKLKKMDS 4686
Query: 433 REGDTVTLSCNYNSSNP-------------SVTRYEWKPHGAWEEPSLGVLKIQNV-GWD 478
+G + L C S+P + +Y++ H + L+I + G D
Sbjct: 4687 IKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFH-----DNTAFLEISQLEGTD 4741
Query: 479 NTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLS-EIHSGNSVSLQCDFSSSHPK 537
+ T C+A N L V+ P V KP S +++ V L+ + P
Sbjct: 4742 SGTYTCSATNKAGHNQCSGHLTVKEPPYFVE----KPQSQDVNPNTRVQLKALVGGTAPM 4797
Query: 538 EVQFFWEKN------GRLLGKE---SQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLE 588
+++F + R + K+ + L + D+G+Y C ++N +G SKA TL
Sbjct: 4798 TIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKA-TLF 4856
Query: 589 VLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNN-QSLPYHS------ 641
V P+ ++ SP + G+S T C+ P + + D N ++ H
Sbjct: 4857 VKEPPQFIK-KPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDG 4915
Query: 642 -QKLRLEPVKVQHSGAYWCQGTNSVG 666
++ +V++SG Y C+ N G
Sbjct: 4916 LATFQISGARVENSGTYVCEARNDAG 4941
Score = 67.8 bits (164), Expect = 4e-11
Identities = 114/520 (21%), Positives = 205/520 (39%), Gaps = 77/520 (14%)
Query: 218 TCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTV 277
TC + + G + T L V PK +K + IV+ GDS + C+++ S PE V
Sbjct: 5401 TCHVTNDVGS--DSCTTMLLVTEPPKF-VKKLEASKIVKAGDSSRLECKIAGS-PEIRVV 5456
Query: 278 SWLKDGTSL----KKQNTF-----TLNLREVTKDQSGKYCCQVSNDVGPGR-SEEVFLQV 327
W ++ L K + TF + + ++ + SG + C+ N G S +V ++
Sbjct: 5457 -WFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKE 5515
Query: 328 Q--YAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV---- 381
++ P V+ L + ++V C P P WY + ++++ + K+
Sbjct: 5516 PPVFSSFPPIVETL-----KNAEVSLECELSGTP-PFEVVWYKDKRQLRSSKKYKIASKN 5569
Query: 382 -----HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGD 436
HI + G Y C A+N +G+ +L + PP+ V+ + N + + G+
Sbjct: 5570 FHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKL--KEPPRFVSKL--NSLTVVAGE 5625
Query: 437 TVTLSCNYNSSNPSVTRY-EWKPHGAWEEPSLGVLKIQNVGWDNTTIA---------CAA 486
L + + P ++ + K E ++ + ++NV A C
Sbjct: 5626 PAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQI 5685
Query: 487 CNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKN 546
N + L V V V K P++ + G + +L+C + + V+ W K+
Sbjct: 5686 KNDGGMRENMATLMVLEPA--VIVEKAGPMT-VTVGETCTLECKVAGTPELSVE--WYKD 5740
Query: 547 GRLL-----------GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAW--TLEVLYAP 593
G+LL K S L S+ +DAG+Y+ V N++G+++ A + P
Sbjct: 5741 GKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPP 5800
Query: 594 RRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQ---SLPYHSQ------KL 644
R + G + G S L C+ + P+S WF + Y + L
Sbjct: 5801 SFTRRLKNTGGVL--GASCILECKVAGSSPIS-VAWFHEKTKIVSGAKYQTTFSDNVCTL 5857
Query: 645 RLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETI 684
+L + G Y C N G + LTV P +
Sbjct: 5858 QLNSLDSSDMGNYTCVAANVAGSDEC-RAVLTVQEPPSFV 5896
Score = 67.0 bits (162), Expect = 7e-11
Identities = 85/355 (23%), Positives = 144/355 (40%), Gaps = 47/355 (13%)
Query: 104 LSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHI--QLPPEIQESQEVTLTC 161
L++ V DSGQ ++ K LN+ ER PP +L ++E++ +
Sbjct: 8210 LTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFK- 8268
Query: 162 LLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQL 221
L PI + W + ++ + + +T K+ L+ + + TC++
Sbjct: 8269 LEGRVAGSQPITVAWYKNNIEIQPTS--NCEITFKN--NTLVLQVRKAGMNDAGLYTCKV 8324
Query: 222 QDADGKFLSNDTVQLNV-KHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWL 280
+ G L ++ + K P + +TP V EG+ V ++C V S P + WL
Sbjct: 8325 SNDAGSALCTSSIVIKEPKKPPVFDQHLTP--VTVSEGEYVQLSCHVQGSEP--IRIQWL 8380
Query: 281 KDGTSLKKQN---------TFTLNLREVTKDQSGKYCCQVSNDVGPGRSE-EVFLQVQYA 330
K G +K + T L LR+V K SG Y C+ SN G ++ +V ++ + A
Sbjct: 8381 KAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPA 8440
Query: 331 PEPSTVQ--------ILHSP----AVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQ---- 374
P+T + + P VE + F+ +P+P N W GK Q
Sbjct: 8441 VAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIP-NVKWT-KGKWRQLNQG 8498
Query: 375 GRT-------EEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKV 422
GR E K+ I +G Y CVA N G + ++D + +K+
Sbjct: 8499 GRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKI 8553
Score = 66.2 bits (160), Expect = 1e-10
Identities = 117/507 (23%), Positives = 204/507 (40%), Gaps = 91/507 (17%)
Query: 238 VKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK---KQNTF-- 292
VK +P + P + +++E D V + EV+ + P ++W KD T L+ K TF
Sbjct: 4389 VKESPYFTKEFKPIE-VLKEYD-VMLLAEVAGTPP--FEITWFKDNTILRSGRKYKTFIQ 4444
Query: 293 ----TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPA-VEGS 347
+L + + +G+Y C+V+N+VG S +V PS ++ + S + + G
Sbjct: 4445 DHLVSLQILKFVAADAGEYQCRVTNEVG---SSICSARVTLREPPSFIKKIESTSSLRGG 4501
Query: 348 QVEFLCMSLANPLPTNYTWYHNGKEMQGRTEE------------KVHIPKILPWHAGTYS 395
F +L LP TW + E+ TE+ +++ I H G Y
Sbjct: 4502 TAAFQA-TLKGSLPITVTWLKDSDEI---TEDDNIRMTFENNVASLYLSGIEVKHDGKYV 4557
Query: 396 CVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYE 455
C A+N G + A L V+ P + + + +GD TL ++ + +
Sbjct: 4558 CQAKN--DAGIQRCSALLSVKEPATITEEAVS--IDVTQGDPATLQVKFSGTKEITAK-- 4611
Query: 456 WKPHGAWEEPSLG------------VLKI-----QNVGWDNTTIACAACNSWCSWASPVA 498
W G +E +LG +LKI ++ G + S C A
Sbjct: 4612 WFKDG--QELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCK-ARINV 4668
Query: 499 LNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNF 558
L++ P + K+K + I G+ + L+C + SHP +Q+F + ++ + +F
Sbjct: 4669 LDLIIPPSFTK--KLKKMDSI-KGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSF 4725
Query: 559 ---------DSISPEDAGSYSCWVNNSIG--QTASKAWTLEVLYAPRRLRVS-MSPGDQV 606
+ D+G+Y+C N G Q + E Y + + ++P +V
Sbjct: 4726 HDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRV 4785
Query: 607 ----MEGKSATLTCE-----SDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAY 657
+ G +A +T + + + + W D + SL L K SG Y
Sbjct: 4786 QLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSL-------ELFAAKATDSGTY 4838
Query: 658 WCQGTNSVGKGRSPLSTLTVYYSPETI 684
CQ +N VG S +TL V P+ I
Sbjct: 4839 ICQLSNDVGTATSK-ATLFVKEPPQFI 4864
Score = 64.7 bits (156), Expect = 3e-10
Identities = 102/481 (21%), Positives = 181/481 (37%), Gaps = 80/481 (16%)
Query: 251 SDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLREVTK 301
+D V G + + + + P +VSW+KD + + + + L + E T
Sbjct: 6934 ADFSVETGSPIVLEATYTGTPP--ISVSWIKDEYLISQSERCSITMTEKSTILEILESTI 6991
Query: 302 DQSGKYCCQVSNDVGPGRSEEVF--LQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANP 359
+ +Y C + N+ G E + L+ Y EP + H AV G C P
Sbjct: 6992 EDYAQYSCLIENEAGQDICEALVSVLEPPYFIEP----LEHVEAVIGEPATLQCKVDGTP 7047
Query: 360 LPTNYTWYHNGKEMQGRTEEKVH---------IPKILPWHAGTYSCVAENILGTGQRGPG 410
+WY +++ K+ I K+ G YSC A+N +G
Sbjct: 7048 -EIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAV 7106
Query: 411 AELDVQYPPKKVTTVIQNPMPIRE--GDTVTLSCNYNSSNPSVTRYEWKPHGAW--EEPS 466
+ + P +++ + E G V C N S P + W G ++ +
Sbjct: 7107 LVIKARKLPPFFARKLKD---VHETLGFPVAFECRINGSEP--LQVSWYKDGVLLKDDAN 7161
Query: 467 LGVLKIQNVGW------DNTTIA---CAACN--SWCSWASPVALNVQYAPRDVRVRKIKP 515
L + NV D + I C+A N S ++ + L+ P +KP
Sbjct: 7162 LQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFF---DLKP 7218
Query: 516 LS-EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR-----------LLGKESQLNFDSISP 563
+S ++ G S + +C + + P ++ W K+ R L+ + L +
Sbjct: 7219 VSVDLALGESGTFKCHVTGTAP--IKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGK 7276
Query: 564 EDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPP 623
DAG Y+C+ +N G+ + A L V PR ++ + P V + + C+ +P
Sbjct: 7277 GDAGQYTCYASNIAGKDSCSA-QLGVQEPPRFIK-KLEPSRIVKQDEFTRYECKIGGSPE 7334
Query: 624 VSHYTWFDWNNQSLPYHSQKLRLEPV-----------KVQHSGAYWCQGTNSVGKGRSPL 672
+ W+ +++ S K R+ V V+ SG Y C+ N+ G S
Sbjct: 7335 IK-VLWY--KDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391
Query: 673 S 673
S
Sbjct: 7392 S 7392
Score = 63.2 bits (152), Expect = 1e-09
Identities = 110/508 (21%), Positives = 181/508 (35%), Gaps = 74/508 (14%)
Query: 238 VKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQ-------- 289
+K P+ K++ +V G V + + + P +V W KD + ++
Sbjct: 7488 LKAPPRFVKKLSDISTVV--GKEVQLQTTIEGAEP--ISVVWFKDKGEIVRESDNIWISY 7543
Query: 290 --NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGS 347
N TL V +GKY CQ+ ND G +E F + + V+ S V
Sbjct: 7544 SENIATLQFSRVEPANAGKYTCQIKNDAG---MQECFATLSVLEPATIVEKPESIKVTTG 7600
Query: 348 QVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV---------HIPKILPWHAGTYSCVA 398
L ++A + W+ +GKE+ + K+ I + P +G YS
Sbjct: 7601 DTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEV 7660
Query: 399 ENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
+N +G ++ + P T ++ + G +V + C S P W
Sbjct: 7661 QNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGL-SGSSVVMECKVYGSPP--ISVSWFH 7717
Query: 459 HGAWEEPSLGVLKIQNVGWDNT--------------TIACAACNSWCSWASPVALNVQYA 504
G E S G K Q DNT C A N S L V+
Sbjct: 7718 EG--NEISSG-RKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREP 7774
Query: 505 PRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK---------NGRLLGKESQ 555
P V+K P+ ++ +G +V+ + P V +F N L ++
Sbjct: 7775 PS--FVQKPDPM-DVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAE 7831
Query: 556 LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLT 615
L + +G Y+C V+N G+ + T + AP + V + +GK L
Sbjct: 7832 LELFDVDTSQSGEYTCIVSNEAGK--ASCTTHLYIKAPAKF-VKRLNDYSIEKGKPLILE 7888
Query: 616 CESDANPPVSHYTW---------FDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG 666
PP+S TW N + S L + V+ +G Y C N+ G
Sbjct: 7889 GTFTGTPPIS-VTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASG 7947
Query: 667 KGRSPLSTLTV---YYSPETIGRRVAVG 691
K L + Y+ + +V+VG
Sbjct: 7948 KDSCSAQILILEPPYFVKQLEPVKVSVG 7975
Score = 57.8 bits (138), Expect = 4e-08
Identities = 122/618 (19%), Positives = 222/618 (35%), Gaps = 72/618 (11%)
Query: 99 NKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVT 158
+ C L+++ + +DSG + L V E P P ++ VT
Sbjct: 7734 DNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVT 7793
Query: 159 LTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVT 218
T ++ + P + W + + SL + EL F S G+ T
Sbjct: 7794 FTSIVKGTP---PFSVSWFKGSSELVPGDRCNVSL--EDSVAELEL-FDVDTSQSGEY-T 7846
Query: 219 CQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVS 278
C + + GK ++ T L +K K ++ +D + +G + + + + P +V+
Sbjct: 7847 CIVSNEAGK--ASCTTHLYIKAPAKFVKRL--NDYSIEKGKPLILEGTFTGTPP--ISVT 7900
Query: 279 WLKDGTSLKK---------QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQY 329
W K+G ++ + + L + T + +G+Y C + N G + Q+
Sbjct: 7901 WKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASG---KDSCSAQILI 7957
Query: 330 APEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPW 389
P V+ L V L LA +WY +++ T K+H +
Sbjct: 7958 LEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVAT 8017
Query: 390 ---------HAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTL 440
+G Y C AEN +G + Q P + +++ G V
Sbjct: 8018 LVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQET-VGLPVVF 8076
Query: 441 SCNYNSSNP-SVTRY-EWKPHGAWEEPSLGVLKIQNVGWDNT--TIACAACNSWCSWASP 496
C + S P SV+ Y + KP + P++ + N N T A C+ +P
Sbjct: 8077 DCAISGSEPISVSWYKDGKP--LKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNP 8134
Query: 497 VALNVQYAPRDVRVRKIKPLSEIHS-------GNSVSLQCDFSSSHPKEVQFFWEKNGR- 548
+ A + K P +I G S +C + + P +V W K+ R
Sbjct: 8135 IGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVS--WAKDSRE 8192
Query: 549 ----------LLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKA-WTLEVLYAPRRLR 597
L + L + D+G Y+C+ N +G+ + A ++ P
Sbjct: 8193 IRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFT 8252
Query: 598 VSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWN-------NQSLPYHSQKLRLEPVK 650
+S + EG S L + P++ W+ N N + + + L L+ K
Sbjct: 8253 KRLSETVEETEGNSFKLEGRVAGSQPIT-VAWYKNNIEIQPTSNCEITFKNNTLVLQVRK 8311
Query: 651 --VQHSGAYWCQGTNSVG 666
+ +G Y C+ +N G
Sbjct: 8312 AGMNDAGLYTCKVSNDAG 8329
Score = 57.4 bits (137), Expect = 6e-08
Identities = 81/349 (23%), Positives = 133/349 (38%), Gaps = 45/349 (12%)
Query: 81 KDGK--VPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSE 138
KDG+ V S++ R+ F KN L + L+DSGQ + ++ V +
Sbjct: 4052 KDGRPLVASKKYRISF---KNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLD 4108
Query: 139 RPFPPHIQLPPEIQESQEVTLTCLLNFSCYG-YPIQLQWLLEGVPMRQAAVTSTSLTIKS 197
R P P +S V TC L+ G P+++ W +G + S I
Sbjct: 4109 RDIAPFFTKPLRNVDS-VVNGTCRLDCKIAGSLPMRVSWFKDG----KEIAASDRYRIAF 4163
Query: 198 VFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVRE 257
V + L+ + TC+ ++ G + + L V+ P K P V
Sbjct: 4164 VEGTASLEIIRVDMNDAGNFTCRATNSVGS--KDSSGALIVQEPPSFVTK--PGSKDVLP 4219
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGTSL---------KKQNTFTLNLREVTKDQSGKYC 308
G +V + S P T+ W K L K+ +L L V SG Y
Sbjct: 4220 GSAVCLKSTFQGSTP--LTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYT 4277
Query: 309 CQVSNDVGPGR-SEEVFLQVQYAPEPSTVQILHSPA---VEGSQVEFLCMSLANPLPTNY 364
C+VSN G S +F++ EP+T P+ +G + C P P
Sbjct: 4278 CKVSNVAGGVECSANLFVK-----EPATFVEKLEPSQLLKKGDATQLACKVTGTP-PIKI 4331
Query: 365 TWYHNGKEMQGRTEEK---------VHIPKILPWHAGTYSCVAENILGT 404
TW+ N +E++ ++ + + + + +G Y C A+N G+
Sbjct: 4332 TWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGS 4380
Score = 55.1 bits (131), Expect = 3e-07
Identities = 61/200 (30%), Positives = 89/200 (44%), Gaps = 34/200 (17%)
Query: 254 IVREGDSVTMTCEVSSSN-PEYTTVSWLKDGTSLKK------QNTFT-----LNLREVTK 301
+V EG + T +S PE VSW +DG + Q +F+ L + VTK
Sbjct: 16 VVLEGSTATFEAHISGFPVPE---VSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTK 72
Query: 302 DQSGKYCCQVSNDVGPGRS-EEVFLQVQYAPEPSTVQILHSPAV-EGSQVEFLCMSLANP 359
SG+Y + +N G S E+ ++ + AP P+ VQ L S V +GSQV P
Sbjct: 73 ANSGRYSLKATNGSGQATSTAELLVKAETAP-PNFVQRLQSMTVRQGSQVRLQVRVTGIP 131
Query: 360 LPTNYTWYHNGKEMQGRTEEKVH---------IPKILPWHAGTYSCVAENILGTGQRGPG 410
P +Y +G E+Q + ++ I + P +GTYS A N G+
Sbjct: 132 TPV-VKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN--SVGRATST 188
Query: 411 AELDVQ----YPPKKVTTVI 426
AEL VQ P KK T++
Sbjct: 189 AELLVQGEEEVPAKKTKTIV 208
Score = 53.5 bits (127), Expect = 8e-07
Identities = 77/350 (22%), Positives = 126/350 (36%), Gaps = 41/350 (11%)
Query: 81 KDGKVPSEQKRVQ--FLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSE 138
KDGK + VQ FL + TL+I + +GQ + L ++E
Sbjct: 8092 KDGKPLKDSPNVQTSFL---DNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTE 8148
Query: 139 RPFPPHIQL---PPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTI 195
PP + P + + C + + PI++ W + +R S
Sbjct: 8149 GKNPPFFDIRLAPVDAVVGESADFECHVTGT---QPIKVSWAKDSREIRSGGKYQISYLE 8205
Query: 196 KSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHT--PKLEIKVTPSDA 253
S + LK S TC + GK + T QLN+K P K
Sbjct: 8206 NSAHL-TVLKVDKGDSGQ---YTCYAVNEVGK--DSCTAQLNIKERLIPPSFTKRLSETV 8259
Query: 254 IVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK---------KQNTFTLNLREVTKDQS 304
EG+S + V+ S P TV+W K+ ++ K NT L +R+ + +
Sbjct: 8260 EETEGNSFKLEGRVAGSQP--ITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDA 8317
Query: 305 GKYCCQVSNDVGPGR-SEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTN 363
G Y C+VSND G + + ++ P + EG V+ C + P
Sbjct: 8318 GLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSC-HVQGSEPIR 8376
Query: 364 YTWYHNGKEMQ---------GRTEEKVHIPKILPWHAGTYSCVAENILGT 404
W G+E++ + + + +G Y C A N+ G+
Sbjct: 8377 IQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGS 8426
Score = 51.2 bits (121), Expect = 4e-06
Identities = 94/423 (22%), Positives = 153/423 (36%), Gaps = 56/423 (13%)
Query: 243 KLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTS---------LKKQNTFT 293
KL I V D V+E V CEV N E W ++ + L+K +T
Sbjct: 12639 KLRIVVPLKDTRVKEQQEVVFNCEV---NTEGAKAKWFRNEEAIFDSSKYIILQKDLVYT 12695
Query: 294 LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLC 353
L +R+ D Y ++N G L V+ + +E V F C
Sbjct: 12696 LRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWC 12755
Query: 354 MSLANPLPTNYTWYHNGKEMQGRTEEKVHIPK---ILPWHAGTYSCVAENILGTGQRGPG 410
N L W NG+E+ + K +L + E I+ GQ
Sbjct: 12756 K--VNRLNVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSV 12813
Query: 411 AELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRY-------EWKPHGAWE 463
AEL + P + +++ + E D SC + +V Y E K + +
Sbjct: 12814 AELLIIEAPTEFVEHLED-QTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKFEK 12872
Query: 464 EPSLGVLKIQNVGWDN-TTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSG 522
+ S+ L I++ D+ AC + S L V+ P ++ +R + + E
Sbjct: 12873 DGSIHRLIIKDCRLDDECEYACGVEDR----KSRARLFVEEIPVEI-IRPPQDILEAPGA 12927
Query: 523 NSVSLQCDFSSSHPKEVQFFWEKNGRLL-----------GKESQLNFDSISPEDAGSYSC 571
+ V L + + +V+ W +N ++ GK +L I P D G Y
Sbjct: 12928 DVVFL----AELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEY-- 12981
Query: 572 WVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVME-GKSATLTCESDANPPVSHYTWF 630
I + LE+ AP ++ + D V++ GK T+ DA P + WF
Sbjct: 12982 ---RFIAKDKEARAKLELAAAP---KIKTADQDLVVDVGKPLTMVVPYDAYPK-AEAEWF 13034
Query: 631 DWN 633
N
Sbjct: 13035 KEN 13037
Score = 47.8 bits (112), Expect = 4e-05
Identities = 117/538 (21%), Positives = 190/538 (35%), Gaps = 101/538 (18%)
Query: 226 GKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTS 285
GK S T+ + +H +E + D V E CEVS + TV W+KD
Sbjct: 3043 GKATSTATLYVEARH---IEFRKHIKDIKVLEKKRAMFECEVSEPD---ITVQWMKDDQE 3096
Query: 286 L---------KKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTV 336
L K++ L + +GKY +V + V+ V
Sbjct: 3097 LQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEV 3156
Query: 337 QILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK-----------VHIPK 385
Q++ + + VEF N + WY +G E+ + +E+ + I +
Sbjct: 3157 QVIEK---QRAVVEFE----VNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISE 3209
Query: 386 ILPWHAGTYSCVAENILGTGQRGPGAELDVQYP-PKKVTTVIQNPMPIREGDTVTLSCNY 444
AG Y+ VA G+ L V P P +V +Q P+ ++ G
Sbjct: 3210 TRQSDAGEYTFVA------GRNRSSVTLYVNAPEPPQVLQELQ-PVTVQSGKPARFCAVI 3262
Query: 445 NSS-NPSVTRYE--------WKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWAS 495
+ P ++ Y+ +K + +L I+ D C A N + +
Sbjct: 3263 SGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATT 3322
Query: 496 PVALNVQYAPRDVRVRK---------IKPLSEI--HSGNSVSLQCDFSSSHPKEVQFFWE 544
+L+V+ P V + I PL + G QC S + K + +
Sbjct: 3323 SASLSVE-VPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLKVSWYSKD 3381
Query: 545 KN------GRLLGKES--QLNFDSISPEDAGSYSCWVNNSIGQTASKA-WTLE----VLY 591
K R+ E QL PED G+Y+ +N++GQ +S A +LE +L+
Sbjct: 3382 KKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILH 3441
Query: 592 APRRLRVSMSPGD-----------QVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYH 640
+ M +V G A TCE + P V + WF + Y
Sbjct: 3442 ERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNV-RFQWFKAGREI--YE 3498
Query: 641 SQK-----------LRLEPVKVQHSGAYWCQGTNSVGK-GRSPLSTLTVYYSPETIGR 686
S K L + +V G Y C+ +N G + T+T Y P + R
Sbjct: 3499 SDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSR 3556
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/200 (21%), Positives = 78/200 (39%), Gaps = 31/200 (15%)
Query: 174 LQWLLEGVPMRQA-------AVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADG 226
++W+L GV + + + + +LTIK R E I+TC + +G
Sbjct: 33068 VKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDE-----------GILTCISKTKEG 33116
Query: 227 KFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSS-NPEYTTVSWLKDGTS 285
+ L+ + + P + EG +V TCE+S +PE + W K+
Sbjct: 33117 IVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPE---IEWFKNNLP 33173
Query: 286 L---------KKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTV 336
+ + +N ++L +R + SGKY + N G + + + EPS
Sbjct: 33174 ISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSRE 33233
Query: 337 QILHSPAVEGSQVEFLCMSL 356
+L + Q F S+
Sbjct: 33234 VVLRTSGDTSLQGSFSSQSV 33253
Score = 42.7 bits (99), Expect = 0.001
Identities = 58/237 (24%), Positives = 97/237 (40%), Gaps = 33/237 (13%)
Query: 244 LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQ 303
++IK T + V E T E++ +P V W+K+G L+ + ++++
Sbjct: 2707 VKIKKTLKNLTVTETQDAVFTVELT--HPNVKGVQWIKNGVVLESNEKYAISVKGTIYSL 2764
Query: 304 SGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP----AVEGSQVEFLCMSLANP 359
K C V V R + + E TV+I+ P A+E + V F +
Sbjct: 2765 RIKNCAIVDESVYGFRLGRLGASARLHVE--TVKIIKKPKDVTALENATVAFEVSVSHDT 2822
Query: 360 LPTNYTWYHNGKEMQGR------TEEKVH---IPKILPWHAGTYSCVAENILGTGQRGPG 410
+P W+H E++ +E KVH + I P AG Y+ V GQ
Sbjct: 2823 VPVK--WFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAV------VGQLECK 2874
Query: 411 AELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSN-PSVTRYEWKPHGAWEEPS 466
A+L V+ +T ++N + + E T + C + N PS+ W +G E S
Sbjct: 2875 AKLFVE--TLHITKTMKN-IEVPETKTASFECEVSHFNVPSM----WLKNGVEIEMS 2924
Score = 42.0 bits (97), Expect = 0.002
Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 10/73 (13%)
Query: 263 MTCEVSSSNPEYTTVSWLKDGTSLKK----------QNTFTLNLREVTKDQSGKYCCQVS 312
+TC V SS V+W KDG LK+ T+ L + +T+ G+Y C++S
Sbjct: 32735 LTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 32794
Query: 313 NDVGPGRSEEVFL 325
+ G ++ F+
Sbjct: 32795 GEGGTSKTNLQFM 32807
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/195 (23%), Positives = 71/195 (36%), Gaps = 27/195 (13%)
Query: 246 IKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN---------TFTLNL 296
I+ D + G++ ++C++ + W + G L + T TL +
Sbjct: 30535 IRKEMKDVTTKLGEAAQLSCQIVGR--PLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 30592
Query: 297 REVTKDQSGKYCCQVSNDVGP-GRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMS 355
++ G Y C +N+VG S ++ LQ P GS + M
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMY 30652
Query: 356 LANPLPTNYTWYHNGKEMQG-------RTEEKVHIPK---ILPWHAGTYSCVAENILGTG 405
+ P+P TW+H K +Q TE H+ HAG Y N+ GT
Sbjct: 30653 IGRPVPA-MTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGT- 30710
Query: 406 QRGPGAELDVQYPPK 420
A LDV+ K
Sbjct: 30711 ---VDAILDVEIQDK 30722
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/226 (21%), Positives = 89/226 (39%), Gaps = 36/226 (15%)
Query: 231 NDTVQL-NVKHTPKLEIKVT-PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK 288
N+ VQ ++ P++++ V + I + G+ V + P TV+W KD +L
Sbjct: 27257 NEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPP--TVTWRKDEKNLGS 27314
Query: 289 QNTFT---------LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAP-------- 331
++ L + +VT++ +GKY + N VG +S V ++V P
Sbjct: 27315 DARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQV 27374
Query: 332 ---EPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILP 388
TV +L P + + + T TW + + + + + + P
Sbjct: 27375 KHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTP 27434
Query: 389 WHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIRE 434
+ + +AEN +G G+ E P K V P PIR+
Sbjct: 27435 FF---FRVLAENEIGIGEPCETTE------PVKAAEV---PAPIRD 27468
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/136 (27%), Positives = 61/136 (44%), Gaps = 32/136 (23%)
Query: 210 WSHHGKIVTCQLQDADGK---------FLSND-------TV-QLNVKH---TPKLEIKVT 249
WSH G TC+++ + K F N+ T+ + VK TP++++
Sbjct: 27509 WSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDI 27568
Query: 250 PSDAI-VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLREV 299
P + VR G +V + E+ ++SWLKDG LK+ +N TL+++
Sbjct: 27569 PGAQVTVRIGHNVHL--ELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNA 27626
Query: 300 TKDQSGKYCCQVSNDV 315
K+ GKY + N V
Sbjct: 27627 KKEHGGKYTVILDNAV 27642
Score = 40.0 bits (92), Expect = 0.009
Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 19/105 (18%)
Query: 244 LEIKVTPSDAI-------VREGDSVTMTCEVSSSNPEYTTVSWLKDG----TSLKKQNTF 292
+EI VTP + V EG+SVT+ C +S TV+W ++ +S+ Q TF
Sbjct: 936 VEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSP--TVTWYREDYQIESSIDFQITF 993
Query: 293 T-----LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPE 332
L +RE + SG++ C N+ G S +L VQ + E
Sbjct: 994 QSGIARLMIREAFAEDSGRFTCSAVNEAGT-VSTSCYLAVQVSEE 1037
Score = 39.7 bits (91), Expect = 0.012
Identities = 35/131 (26%), Positives = 56/131 (42%), Gaps = 20/131 (15%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---------KKQNTFTLNLREVTKD 302
D V+EG++ T CE+S E V W K+ L + T L ++EVT D
Sbjct: 11582 DQTVKEGETATFVCELSH---EKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLD 11638
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362
+ QV S L+V A TV++ AVE ++ C ++ +P
Sbjct: 11639 DISQIKAQVKE-----LSSTAQLKVLEADPYFTVKLHDKTAVEKDEITLKC-EVSKDVPV 11692
Query: 363 NYTWYHNGKEM 373
W+ +G+E+
Sbjct: 11693 K--WFKDGEEI 11701
Score = 38.9 bits (89), Expect = 0.020
Identities = 39/166 (23%), Positives = 64/166 (38%), Gaps = 30/166 (18%)
Query: 252 DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQ---------NTFTLNLREVTKD 302
D ++EG + TMTC+ S N W ++G LK Q L + +V +
Sbjct: 8753 DVTLKEGQTCTMTCQFSVPN---VKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAE 8809
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLC-MSLANPLP 361
G+Y C+ + L+++ P T +I + E F C +S + +
Sbjct: 8810 DQGQYTCKYED-----LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFDDAI- 8863
Query: 362 TNYTWYHNGKEM------QGRTEEKVH---IPKILPWHAGTYSCVA 398
TWY E+ R + + H I + P G YS +A
Sbjct: 8864 --VTWYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIA 8907
Score = 38.9 bits (89), Expect = 0.020
Identities = 84/389 (21%), Positives = 135/389 (34%), Gaps = 77/389 (19%)
Query: 97 DKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPP-EIQESQ 155
++ K +L +H L+ +G G+ ++ K HL V R L + +
Sbjct: 12156 EEGKIHSLVLHNCRLDQTG--GVDFQAANVK--SSAHLRVKPRVIGLLRPLKDVTVTAGE 12211
Query: 156 EVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGK 215
T C L++ I ++W L+G + + V RSE GK
Sbjct: 12212 TATFDCELSYE----DIPVEWYLKGKKLEPS---------DKVVPRSE----------GK 12248
Query: 216 IVTCQLQDADGKFLSNDTVQLNVKH----------TPKLEIKVTPSDAIVREGDSVTMTC 265
+ T L+D K VQL K P +E D V EG + + C
Sbjct: 12249 VHTLTLRDV--KLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLEC 12306
Query: 266 EVSSSNPEYTTVSWLKDGTSLKKQNTF---------TLNLREVTKDQSGKYCCQVSNDVG 316
EVS N + V W K+GT + K + L + + T + Y C +
Sbjct: 12307 EVSRENAK---VKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKT 12363
Query: 317 PGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLC-MSLANPLPTNYTWYHNGKEM-Q 374
V V++ + +Q+ E F C +S N W+ +G E+ +
Sbjct: 12364 SCNLNVVPPHVEFLRPLTDLQVR-----EKEMARFECELSREN---AKVKWFKDGAEIKK 12415
Query: 375 GRTEEKVH--------IPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVI 426
G+ + + I K L YSC +G L V T +
Sbjct: 12416 GKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGM------LTVLEEEAVFTKNL 12469
Query: 427 QNPMPIREGDTVTLSCNYNSSNPSVTRYE 455
N + + E DT+ L C + V Y+
Sbjct: 12470 AN-IEVSETDTIKLVCEVSKPGAEVIWYK 12497
Score = 38.5 bits (88), Expect = 0.026
Identities = 59/326 (18%), Positives = 126/326 (38%), Gaps = 40/326 (12%)
Query: 255 VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT---------LNLREVTKDQSG 305
V E D++ + CEVS E V W K + + + L ++ + +G
Sbjct: 12474 VSETDTIKLVCEVSKPGAE---VIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAG 12530
Query: 306 KYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
Y C++ + G+ + L ++ +P ++IL EG + EF+C P
Sbjct: 12531 NYNCRLPSSRTDGKVKVHELAAEFISKPQNLEIL-----EGEKAEFVCSISKESFPVQ-- 12583
Query: 366 WYHNGKEMQGRTEEKVHI---PKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKV 422
W + K ++ + V ++L T + ++ G A L V +K+
Sbjct: 12584 WKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV---IEKL 12640
Query: 423 TTVIQ-NPMPIREGDTVTLSCNYNSSNPSV-------TRYEWKPHGAWEEPSLGVLKIQN 474
V+ ++E V +C N+ ++ + ++ + L+I++
Sbjct: 12641 RIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRD 12700
Query: 475 VGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS--GNSVSLQCDFS 532
D+ + + A N+ D+R+ ++PL +I + SV+ C +
Sbjct: 12701 AHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRI--VEPLKDIETMEKKSVTFWCKVN 12758
Query: 533 SSHPKEVQFFWEKNGRLLGKESQLNF 558
+ V W KNG + ++++++
Sbjct: 12759 RLN---VTLKWTKNGEEVPFDNRVSY 12781
Score = 38.1 bits (87), Expect = 0.035
Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 13/102 (12%)
Query: 242 PKLEIKVTPSDAI-VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK---------KQNT 291
P++++ V + V+ G +V + V TVSW KDGT LK ++N
Sbjct: 19293 PRIDLSVAMKSLLTVKAGTNVCLDATVFGK--PMPTVSWKKDGTLLKPAEGIKMAMQRNL 19350
Query: 292 FTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEP 333
TL L V + SG Y N G +S + L+V P P
Sbjct: 19351 CTLELFSVNRKDSGDYTITAENSSG-SKSATIKLKVLDKPGP 19391
Score = 36.6 bits (83), Expect = 0.10
Identities = 34/163 (20%), Positives = 64/163 (39%), Gaps = 37/163 (22%)
Query: 253 AIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLN---------LREVTKDQ 303
A+ EG V C++ + + + T V+W L+ + + ++++TK
Sbjct: 31577 AVGEEGGHVKYVCKIENYD-QSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLD 31635
Query: 304 SGKYCCQVSNDVGPGRS---------EEVF-----------------LQVQYAPEPSTVQ 337
G Y C+V ND G S EV+ +++ P T+
Sbjct: 31636 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 31695
Query: 338 ILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK 380
+ + A G V F +P P + TWY +G++++ +K
Sbjct: 31696 LYNKTAYVGENVRFGVTITVHPEP-HVTWYKSGQKIKPGDNDK 31737
Score = 36.2 bits (82), Expect = 0.13
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 11/81 (13%)
Query: 245 EIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF---------TLN 295
++K S V+ G + + EV S T++W KDG LK+ TL+
Sbjct: 23231 DVKPAFSSYSVQVGQDLKI--EVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLS 23288
Query: 296 LREVTKDQSGKYCCQVSNDVG 316
++E KD G+Y V+N VG
Sbjct: 23289 IKETHKDDGGQYGITVANVVG 23309
Score = 35.8 bits (81), Expect = 0.17
Identities = 68/325 (20%), Positives = 116/325 (35%), Gaps = 85/325 (26%)
Query: 333 PSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV---------HI 383
P + QI+H+ EG V+++C T TWY ++++ + ++ ++
Sbjct: 31569 PVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYV 31628
Query: 384 PKILPWHAGTYSCVAENILGTGQRGPGAELDV---------------------------- 415
I GTY C N G+ AEL V
Sbjct: 31629 KDITKLDDGTYRCKVVN--DYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLL 31686
Query: 416 QYPPK-------KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW----------KP 458
+ PP+ K V +N +R G T+T+ P VT Y+ K
Sbjct: 31687 ERPPEFTLPLYNKTAYVGEN---VRFGVTITV-----HPEPHVTWYKSGQKIKPGDNDKK 31738
Query: 459 HGAWEEPSLGVLKIQNVGWDNT---TIACAACNSWCSWASPVALNVQYAPRDVRVR---- 511
+ + L L I +V D+ T+ S + + + + P D +R
Sbjct: 31739 YTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFK 31798
Query: 512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR--LLGKESQLNFDSIS------- 562
++ +E G SV + S P ++ WEK+G+ LG ++ + +
Sbjct: 31799 RLLANAECQEGQSVCFEIRVSGIPPPTLK--WEKDGQPLSLGPNIEIIHEGLDYYALHIR 31856
Query: 563 ---PEDAGSYSCWVNNSIGQTASKA 584
PED G Y N+ G T+ +A
Sbjct: 31857 DTLPEDTGYYRVTATNTAGSTSCQA 31881
Score = 35.4 bits (80), Expect = 0.22
Identities = 107/543 (19%), Positives = 200/543 (36%), Gaps = 87/543 (16%)
Query: 86 PSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHI 145
PS++ R+ +K +I P + + ++E K + ++E +H+ + +
Sbjct: 2836 PSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLHITKTMKNI---- 2891
Query: 146 QLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELK 205
E+ E++ + C ++ + + WL GV + + + K
Sbjct: 2892 ----EVPETKTASFECEVSH----FNVPSMWLKNGVEIEMS---------------EKFK 2928
Query: 206 FSPQWSHHGKIV--TCQLQDADGKFL-SNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVT 262
Q H I+ T A+ F+ ND V + TP + I D E D++T
Sbjct: 2929 IVVQGKLHQLIIMNTSTEDSAEYTFVCGNDQVSATLTVTP-IMITSMLKDINAEEKDTIT 2987
Query: 263 MTCEVSSSNPEYTTVSWLKDGTSLK---------KQNTFTLNLREVTKDQSGKYCCQVSN 313
V N E + WLK+G +K K+ T +LN+R V + Y
Sbjct: 2988 FEVTV---NYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGK 3044
Query: 314 DVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEM 373
+++ +++L E + F C ++ P W + +E+
Sbjct: 3045 ATSTATLYVEARHIEFRKHIKDIKVL-----EKKRAMFEC-EVSEP-DITVQWMKDDQEL 3097
Query: 374 Q------GRTEEKVH---IPKILPWHAGTYSCVAENILGTGQR-GPGAELDVQYPPKKVT 423
Q + E+ VH IP AG Y+ VA + T + G ++ ++ K+V
Sbjct: 3098 QITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQ 3157
Query: 424 TVIQNPMPIR-EGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKI----QNVGWD 478
+ + + E + + ++ + + H E + + I Q+ +
Sbjct: 3158 VIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGE 3217
Query: 479 NTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKE 538
T +A S V L V +++++P++ + SG C S P +
Sbjct: 3218 YTFVAGRN-------RSSVTLYVNAPEPPQVLQELQPVT-VQSGKPARF-CAVISGRP-Q 3267
Query: 539 VQFFWEKNGRLL-----------GKESQLNFDSISPEDAGSYSCWVNNSIG-QTASKAWT 586
+ W K +LL G+E L PEDA Y+C N G T S + +
Sbjct: 3268 PKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLS 3327
Query: 587 LEV 589
+EV
Sbjct: 3328 VEV 3330
Score = 35.0 bits (79), Expect = 0.29
Identities = 34/142 (23%), Positives = 51/142 (35%), Gaps = 13/142 (9%)
Query: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
+S+ +KS T + S H + + K L + +K T I
Sbjct: 32508 SSSVREVKSQMTETRESLSSY--EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILT 32565
Query: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDG----TSLKKQNT-----FTLNLREV 299
P V EG+S +C+ + TV+WL+ G TS + Q T T + V
Sbjct: 32566 KPRSMTVYEGESARFSCD--TDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 32623
Query: 300 TKDQSGKYCCQVSNDVGPGRSE 321
G Y V N G +E
Sbjct: 32624 QASDEGNYSVVVENSEGKQEAE 32645
Score = 34.7 bits (78), Expect = 0.38
Identities = 24/72 (33%), Positives = 31/72 (43%), Gaps = 15/72 (20%)
Query: 344 VEGSQVEFLCMSLANPLPTNYTWYHNGKEMQ------------GRTEEKVHIPKILPWHA 391
+EG V F C PLP WY +GK ++ GR + IP +LP
Sbjct: 1303 LEGMGVTFHCKMSGYPLP-KIAWYKDGKRIKHGERYQMDFLQDGRAS--LRIPVVLPEDE 1359
Query: 392 GTYSCVAENILG 403
G Y+ A NI G
Sbjct: 1360 GIYTAFASNIKG 1371
Score = 33.9 bits (76), Expect = 0.65
Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 12/87 (13%)
Query: 254 IVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQ---------NTFTLNLREVTKDQS 304
I++ G+S+ + V V+W KDG ++K+ + +L +R+ T+D
Sbjct: 27969 IIKSGESLRIKALVQGR--PVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHR 28026
Query: 305 GKYCCQVSNDVGPGRSEEVFLQVQYAP 331
G Y + N G ++ E+ ++VQ P
Sbjct: 28027 GVYTVEAKNASGSAKA-EIKVKVQDTP 28052
Score = 33.5 bits (75), Expect = 0.85
Identities = 49/199 (24%), Positives = 77/199 (38%), Gaps = 45/199 (22%)
Query: 277 VSWLKDGTSLKK------QNTFT---LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQV 327
+SW+KDG LK+ + T T L+++E KD GKY +N G +E + + V
Sbjct: 24343 ISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTA-TENLSVIV 24401
Query: 328 QYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT------NY---------TWYHNGKE 372
P P + + +F+ +S P T NY T +H
Sbjct: 24402 LEKPGPPVGPV----RFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSA 24457
Query: 373 MQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKK--------VTT 424
RT + I K+ + AEN G + VQYP K+ VT+
Sbjct: 24458 TVART--TIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS 24515
Query: 425 VIQNPM------PIREGDT 437
+ ++ M P+ +G T
Sbjct: 24516 ISKDQMLVQWHEPVNDGGT 24534
Score = 33.1 bits (74), Expect = 1.1
Identities = 24/102 (23%), Positives = 45/102 (44%), Gaps = 13/102 (12%)
Query: 224 ADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDG 283
+D + L + +++ P +E+ + RE + +V TV+W KDG
Sbjct: 25377 SDPRQLGVPVIARDIEIKPSVELPFHTFNVKARE----QLKIDVPFKGRPQATVNWRKDG 25432
Query: 284 TSLKK---------QNTFTLNLREVTKDQSGKYCCQVSNDVG 316
+LK+ + +L+++E +K+ G Y VSN G
Sbjct: 25433 QTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAG 25474
Score = 32.3 bits (72), Expect = 1.9
Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 7/133 (5%)
Query: 80 TKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSER 139
TKDG + R+ + D TLSI H +D GQ G+ + + + I + ++
Sbjct: 23264 TKDGLPLKQTTRIN-VTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDK 23322
Query: 140 PFPPHIQLPPEIQESQEVTLTC---LLNFSCY--GYPIQLQWLLEGV-PMRQAAVTSTSL 193
P PP + + ++ +TL+ L C Y +Q + V + A V T+L
Sbjct: 23323 PDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTL 23382
Query: 194 TIKSVFTRSELKF 206
+ + T +E +F
Sbjct: 23383 KVTKLKTGTEYQF 23395
Score = 31.2 bits (69), Expect = 4.2
Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 14/88 (15%)
Query: 255 VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN---------TFTLNLREVTKDQSG 305
+R G++ +T S VSW KD + + + T L + + SG
Sbjct: 16830 IRVGEAFALTGRYSGKPKP--KVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSG 16887
Query: 306 KYCCQVSNDVGPGRSEEVFLQVQYAPEP 333
KYC V N G S + F QV P
Sbjct: 16888 KYCVVVENSTG---SRKGFCQVNVVDRP 16912
Score = 31.2 bits (69), Expect = 4.2
Identities = 18/63 (28%), Positives = 30/63 (47%), Gaps = 1/63 (1%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG + + ++ +N CTL + V+ DSG + E+ + I L V ++P
Sbjct: 19331 KDGTLLKPAEGIKMAMQRNL-CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Query: 141 FPP 143
PP
Sbjct: 19390 GPP 19392
Score = 30.4 bits (67), Expect = 7.2
Identities = 28/101 (27%), Positives = 44/101 (43%), Gaps = 19/101 (18%)
Query: 494 ASPVALNVQYAPRDVRVRKIKPLSEI--HSGNSVS---LQCDFSSSHPKEVQFFWEKNGR 548
+ P L V RD+ +IKP E+ H+ N + L+ D + W K+G+
Sbjct: 25377 SDPRQLGVPVIARDI---EIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQ 25433
Query: 549 LLGKESQLNFDS-----------ISPEDAGSYSCWVNNSIG 578
L + +++N S S ED G+Y V+NS G
Sbjct: 25434 TLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAG 25474
Score = 30.0 bits (66), Expect = 9.4
Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 10/70 (14%)
Query: 344 VEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGR---TEEKVHI------PKILPWHAGTY 394
+EG ++ A P+PT +W+ +GKE++ T + HI PK + AG Y
Sbjct: 14399 IEGEKLSIPVPFRAVPVPT-VSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Query: 395 SCVAENILGT 404
+ EN LG+
Sbjct: 14458 TITLENKLGS 14467
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 107 bits (266), Expect = 6e-23
Identities = 152/654 (23%), Positives = 258/654 (39%), Gaps = 83/654 (12%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KD ++ S + FL N+ + I ++D+G K + +E
Sbjct: 1956 KDNRLLSGSTSMTFL---NRGQIIDIESAQISDAG---------IYKCVAINSAGATELF 2003
Query: 141 FPPHIQLPPEIQESQEVTLTCL-----LNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLT 194
+ + + P I S + + L G P L WL +G P+ + L+
Sbjct: 2004 YSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLS 2063
Query: 195 IKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAI 254
+ + S Q S G+ TC +A G+ + L V P + + +
Sbjct: 2064 GGRILALT----SAQISDTGRY-TCVAVNAAGE--KQRDIDLRVYVPPNIMGEEQNVSVL 2116
Query: 255 VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK-------QNTFTLNLREVTKDQSGKY 307
+ + +V + C+ + P T++WLKDG L K +N L + + +G+Y
Sbjct: 2117 ISQ--AVELLCQSDAIPPP--TLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRY 2172
Query: 308 CCQVSNDVGPGRSEEVFLQVQYAPEP--STVQILHSPAVEGSQVEFLCMSLANPLPTNYT 365
C+ +N G ++E+ + + P + ++ +EG+ + LC S P P N
Sbjct: 2173 TCEATNVAG--KTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP-PPNLI 2229
Query: 366 WYHNGK----EMQGRTE-----EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQ 416
W G + GR ++ I A YSCVA N+ GT ++ E ++Q
Sbjct: 2230 WKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKK----EYNLQ 2285
Query: 417 -YPPKKVTTVIQNPMPI--REGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVL--- 470
Y +T +P I G +++L C P + H + + +L
Sbjct: 2286 VYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEG 2345
Query: 471 ---KIQNVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVS 526
+++N+ +T C A N L+V P + + + NSVS
Sbjct: 2346 HILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVS 2405
Query: 527 LQCDFSSSHPKEVQFF---W----EKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQ 579
L C+ S + +F W + R+L L + EDAG Y+C V N+ G+
Sbjct: 2406 LTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE 2465
Query: 580 TASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSL-- 637
K + L VL P + + +V E +S TLTCE N PV TW + Q L
Sbjct: 2466 -ERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGN-PVPEITWHK-DGQPLQE 2522
Query: 638 --PYH----SQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIG 685
+H + L++ V+V H+G Y C ++ G +S +L V+ SP G
Sbjct: 2523 DEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGH-KSRSFSLNVFVSPTIAG 2575
Score = 97.8 bits (242), Expect = 4e-20
Identities = 142/645 (22%), Positives = 251/645 (38%), Gaps = 96/645 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
KDG+ E +FL + L I + D G+ E+ + +LNV
Sbjct: 2908 KDGQPLLEDDHHKFLSNGR---ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVH--- 2961
Query: 141 FPPHIQLPPEIQESQEVTLTCLLNFSCY--GYPI-QLQWLLEGVPMRQAAVTSTSLTIKS 197
PP + P E+ V + ++ +C G+P L WL P++ + + +L +
Sbjct: 2962 VPPSVIGPKS--ENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK---LNTNTLIVPG 3016
Query: 198 VFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVRE 257
T ++ G TC + G+ ++ + V + K + S VRE
Sbjct: 3017 GRTLQIIRAKVS---DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVRE 3073
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT-------LNLREVTKDQSGKYCCQ 310
G SV++ CE ++ P ++W K+G + + L++++ +G+Y C+
Sbjct: 3074 GTSVSLECESNAVPPP--VITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131
Query: 311 VSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL---------- 360
N G R ++ F Y P P++EG + E + +++NP+
Sbjct: 3132 AINVAG--RDDKNFHLNVYVP----------PSIEGPEREVIVETISNPVTLTCDATGIP 3179
Query: 361 PTNYTWYHNGKEMQGRTE---------EKVHIPKILPWHAGTYSCVAENILGTGQRGPGA 411
P W N K ++ K+ I + +G Y+C+A N+ G Q+
Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKY--Y 3237
Query: 412 ELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRY--EWKPHGAWEEPSLGV 469
L +Q PP I + + + G+ V L CN N + ++ + KP + E + V
Sbjct: 3238 FLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRV 3297
Query: 470 ------LKIQN-VGWDNTTIACAACNSWCSWASPVALNVQYAP----RDVRVRKIKPLSE 518
L I + D C A N LNV P K+ L +
Sbjct: 3298 SANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVD 3357
Query: 519 IHSGNSVSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSISPEDAGSY 569
S++++C + + P ++ W KNG RLL + D Y
Sbjct: 3358 ----TSINIECRATGTPPPQIN--WLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVY 3411
Query: 570 SCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLTCESDANPPVSHYT 628
+C +N G +K + L+V +AP + SM + V++G S ++ C +D P S
Sbjct: 3412 TCVASNRAG-VDNKHYNLQV-FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW 3469
Query: 629 WFDWN------NQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGK 667
D + ++ H L+L + + SG Y C +N G+
Sbjct: 3470 LRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGE 3514
Score = 95.1 bits (235), Expect = 2e-19
Identities = 134/587 (22%), Positives = 238/587 (40%), Gaps = 72/587 (12%)
Query: 137 SERPFPPHIQLPPEIQESQEVT--------LTCLLNFSCYGYPIQLQWLLEGVPMRQAAV 188
+E+ + +I +PP I S E+T L LL S P L W +G P+ +
Sbjct: 2183 TEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPV----L 2238
Query: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
T + ++ + +L+ S + +C + G +Q+ ++ T
Sbjct: 2239 TDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTIT-NSGS 2297
Query: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK-------QNTFTLNLREVTK 301
P++ IV G S+++ CEV P TV+W+KDG L K L L+ +
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPP--TVTWMKDGHPLIKAKGVEILDEGHILQLKNIHV 2355
Query: 302 DQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP----AVEGSQVEFLCMSLA 357
+G+Y C N G +++ + +AP PS + SP VE + V C +
Sbjct: 2356 SDTGRYVCVAVNVAG--MTDKKYDLSVHAP-PSIIGNHRSPENISVVEKNSVSLTCEASG 2412
Query: 358 NPLPTNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAENILGTGQRGPG 410
PLP+ TW+ +G + ++ + + AG Y+CV N G ++ G
Sbjct: 2413 IPLPS-ITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471
Query: 411 AELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGA--WEEPSLG 468
L V PP V + ++E +VTL+C + NP V W G E+ +
Sbjct: 2472 --LSVLVPPHIVGENTLEDVKVKEKQSVTLTCEV-TGNP-VPEITWHKDGQPLQEDEAHH 2527
Query: 469 V------LKIQNVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521
+ L+I NV +T C A + + +LNV +P V ++
Sbjct: 2528 IISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 522 --GNSVSLQCDFSSSHPKEVQFFWE-------KNGRLLGKESQLNFDSISPEDAGSYSCW 572
+ SL C+ S P + +F + +N R+L L + ++AG YSC
Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCV 2647
Query: 573 VNNSIGQTAS----KAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLTCESDANPPVSHY 627
N G+ K + ++ +SP + ++ + TL CE+ A P S
Sbjct: 2648 ATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSAS-L 2706
Query: 628 TWF-------DWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGK 667
+W+ ++ ++ + L+++ ++ +G Y C +N G+
Sbjct: 2707 SWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGE 2753
Score = 89.7 bits (221), Expect = 1e-17
Identities = 122/503 (24%), Positives = 196/503 (38%), Gaps = 91/503 (18%)
Query: 248 VTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQ-------NTFTLNLREVT 300
++P + ++ +++T+ CE + ++SW KDG LK N TL ++E
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPS--ASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQ 2736
Query: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILH-------------SPAVEGS 347
+G+Y C SN G +E+ V PS ++ + +
Sbjct: 2737 ISDTGRYTCVASNIAG---EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINN 2793
Query: 348 QVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV-------HIPKILPWHAGTYSCVAEN 400
+ C + A P PT TWY +G + + + IP+ AG Y+CVA N
Sbjct: 2794 PISLYCETNAAPPPT-LTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVN 2852
Query: 401 ILGTGQRGPGAELDVQYPP--KKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
G+ ++ V PP K + + + + + + C SS R W+
Sbjct: 2853 --EAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECL--SSGSPAPRNSWQK 2908
Query: 459 HGAWEEPSLG-----------VLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQYAPR 506
G +P L +L+I N D C A N+ S LNV P
Sbjct: 2909 DG---QPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965
Query: 507 DVRVRKIKPLSE---IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL-----------GK 552
I P SE + N +SL C+ S P ++ W KN + + G+
Sbjct: 2966 -----VIGPKSENLTVVVNNFISLTCEVSGFPPPDLS--WLKNEQPIKLNTNTLIVPGGR 3018
Query: 553 ESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVM---EG 609
Q+ +S D G Y+C N G++ K ++L V Y P ++ S V+ EG
Sbjct: 3019 TLQIIRAKVS--DGGEYTCIAINQAGESKKK-FSLTV-YVPPSIKDHDSESLSVVNVREG 3074
Query: 610 KSATLTCESDANPPVSHYTWF-------DWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGT 662
S +L CES+A PP TW+ + + + Q L ++ +V +G Y C+
Sbjct: 3075 TSVSLECESNAVPP-PVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAI 3133
Query: 663 NSVGKGRSPLSTLTVYYSPETIG 685
N G+ L VY P G
Sbjct: 3134 NVAGRDDKNFH-LNVYVPPSIEG 3155
Score = 86.7 bits (213), Expect = 8e-17
Identities = 137/592 (23%), Positives = 226/592 (38%), Gaps = 85/592 (14%)
Query: 81 KDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 140
K+G++ +E V+ L D L I ++D+GQ R + + + HLNV
Sbjct: 3095 KNGRMITESTHVEILADGQM---LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVY--- 3148
Query: 141 FPPHIQLPPE--IQE--SQEVTLTCLLNFSCYGYPIQ-LQWLLEGVPMRQAAVTSTSLTI 195
PP I+ P I E S VTLTC G P + WL + S SL +
Sbjct: 3149 VPPSIEGPEREVIVETISNPVTLTC----DATGIPPPTIAWLKN----HKRIENSDSLEV 3200
Query: 196 KSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIV 255
+ + S+L+ + TC + +GK + L+++ P + PSD V
Sbjct: 3201 RILSGGSKLQIARSQHSDSGNYTCIASNMEGK--AQKYYFLSIQVPPSVAGAEIPSDVSV 3258
Query: 256 REGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNT---------FTLNLREVTKDQSGK 306
G++V + C +++ + WLKDG + T TLN+ +GK
Sbjct: 3259 LLGENVELVC--NANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGK 3316
Query: 307 YCCQVSNDVGPGRSEEVF-LQVQYAP--EPSTVQILHSPAVEGSQVEFLCMSLANPLPTN 363
Y C +N G + +F L V P + + + + + C + P P
Sbjct: 3317 YTCVATNPAG--EEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTP-PPQ 3373
Query: 364 YTWYHNGKEMQGRTE-------EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQ 416
W NG + + + + I + Y+CVA N G + L V
Sbjct: 3374 INWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH--YNLQVF 3431
Query: 417 YPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW--EEPSLGV---LK 471
PP ++ + + +G + +++C +T P AW + LG+ L
Sbjct: 3432 APPNMDNSMGTEEITVLKGSSTSMAC--------ITDGTPAPSMAWLRDGQPLGLDAHLT 3483
Query: 472 IQNVGW----------DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHS 521
+ G D+ C A N + L V P + + +S I +
Sbjct: 3484 VSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVN 3543
Query: 522 GNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ---------LNFDSISPEDAGSYSCW 572
N + L C +S P + W K+GR L + Q L + ED G Y+C
Sbjct: 3544 -NPLELTC-IASGIPAP-KMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCL 3600
Query: 573 VNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLTCESDANPP 623
++ G K + + V + P + + P D V+ + TL C+SDA PP
Sbjct: 3601 ASSPAGDD-DKEYLVRV-HVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPP 3650
Score = 85.1 bits (209), Expect = 2e-16
Identities = 133/587 (22%), Positives = 235/587 (40%), Gaps = 87/587 (14%)
Query: 137 SERPFPPHIQLPPEIQES------QEVTLTCLLNFSCY--GYPIQ-LQWLLEGVPMRQAA 187
+E+ F + +PP I+ + ++V + L C G P L WL +GVP++
Sbjct: 1627 AEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVK--- 1683
Query: 188 VTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIK 247
+ ++ I++ + E+ S Q G+ + A K + +++V P +E
Sbjct: 1684 -ANDNIRIEAGGKKLEI-MSAQEIDRGQYICVATSVAGEKEIK---YEVDVLVPPAIEGG 1738
Query: 248 VTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLR-------EVT 300
S IV + + + C V+ S P T+ WLKDG + +++ F + L +
Sbjct: 1739 DETSYFIVMVNNLLELDCHVTGSPPP--TIMWLKDGQLIDERDGFKILLNGRKLVIAQAQ 1796
Query: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL 360
+G Y C +N G + +E + V P + + V+ V C++ P
Sbjct: 1797 VSNTGLYRCMAANTAGDHK-KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPN 1855
Query: 361 PTNYTWYHNGKEM---QGRTEEK-----VHIPKILPWHAGTYSCVAENILGTGQRGPGAE 412
P+ TW + + + QG + + + I K L AG Y+CVA N G Q+ +
Sbjct: 1856 PS-ITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQH--IQ 1912
Query: 413 LDVQYPPK--------KVTTVIQNPMPIR---EGDTVTLSCNYNSSN--PSVTRYEWKPH 459
L V PP T ++ NP+ + G+ V + Y + T +
Sbjct: 1913 LHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNR 1972
Query: 460 GAWEEPSLGVLKIQNVGWDNTTI-ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSE 518
G ++ I++ + I C A NS + +L V AP + +
Sbjct: 1973 GQ-------IIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS---ISGSNNMVA 2022
Query: 519 IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ----------LNFDSISPEDAGS 568
+ N V L+C+ + W K+G + S L S D G
Sbjct: 2023 VVVNNPVRLECEARGIPAPSLT--WLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGR 2080
Query: 569 YSCWVNNSIGQTASKAWTLEV-LYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHY 627
Y+C N+ G+ K +++ +Y P + + V+ ++ L C+SDA PP +
Sbjct: 2081 YTCVAVNAAGE---KQRDIDLRVYVPPNI-MGEEQNVSVLISQAVELLCQSDAIPPPT-L 2135
Query: 628 TWFDWNNQ-------SLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGK 667
TW + S+ + L++E +VQ +G Y C+ TN GK
Sbjct: 2136 TWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Score = 84.0 bits (206), Expect = 5e-16
Identities = 117/494 (23%), Positives = 187/494 (37%), Gaps = 63/494 (12%)
Query: 234 VQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF- 292
V+LNV PK I+ P V+ G V + C + ++W K G+++
Sbjct: 1163 VKLNVHVPPK--IQRGPKHLKVQVGQRVDIPCNAQGT--PLPVITWSKGGSTMLVDGEHH 1218
Query: 293 ------TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP---- 342
TL++ + T +G Y C +N G +E + L VQ EP TV+ L P
Sbjct: 1219 VSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQ---EPPTVEDLEPPYNTT 1274
Query: 343 ---AVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTE--------EKVHIPKILPWHA 391
V ++EF C + P PT W HNG+E+ GR + I + P+
Sbjct: 1275 FQERVANQRIEFPCPAKGTPKPT-IKWLHNGRELTGREPGISILEDGTLLVIASVTPYDN 1333
Query: 392 GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV 451
G Y CVA N GT +R L V PP + + L C + PS
Sbjct: 1334 GEYICVAVNEAGTTERK--YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGT-PSP 1390
Query: 452 TRYEWKPHGAWEEPSL-------GVLKI-QNVGWDNTTIACAACNSWCSWASPVALNVQY 503
+K + E S +LK+ + D +C A N + ++V
Sbjct: 1391 IIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLV 1450
Query: 504 APRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFF--------WEKNGRLLGKESQ 555
P + +S + + V+L+C + ++ +F + N LL +
Sbjct: 1451 PPTIIGTNFPNEVSVVLN-RDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV 1509
Query: 556 LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLT 615
L+ + D G Y C V+N+ G+ A K L + P +++ V+ L
Sbjct: 1510 LHLKNARRNDKGRYQCTVSNAAGKQA-KDIKLTIYIPPSIKGGNVTTDISVLINSLIKLE 1568
Query: 616 CESDANPPVSHYTWFDWNNQSLPYHSQKLRLEP--------VKVQHSGAYWCQGTNSVGK 667
CE+ P+ TW+ + Q + SQ L ++ +V S Y C N G
Sbjct: 1569 CET-RGLPMPAITWYK-DGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGT 1626
Query: 668 GRSPLSTLTVYYSP 681
+ VY P
Sbjct: 1627 AEKSFH-VDVYVPP 1639
Score = 77.4 bits (189), Expect = 5e-14
Identities = 116/493 (23%), Positives = 183/493 (37%), Gaps = 64/493 (12%)
Query: 142 PPHIQLPPEI--QESQEVTLTCLLNFSCYGYPIQ-LQWL-LEGVPMRQAAVTSTSLTIKS 197
P IQ P ++ + VTL C + GYP ++W L+ +P+ + +S+ S
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQ----GYPEPTIKWRRLDNMPIFSRPFSVSSI---S 845
Query: 198 VFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVRE 257
L W+ C+ ++ GK S TV + P I ++PS A V E
Sbjct: 846 QLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPL--IGISPSVANVIE 903
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT------LNLREVTKDQSGKYCCQV 311
G +T+ C + + NP W+K+ L + T L++ V G+Y C
Sbjct: 904 GQQLTLPCTLLAGNP-IPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVA 962
Query: 312 SNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK 371
SN G ++ + V P Q + S +EG V C + NP P + W G+
Sbjct: 963 SNVAGT-NNKTTSVVVHVLPTIQHGQQILS-TIEGIPVTLPCKASGNPKP-SVIWSKKGE 1019
Query: 372 -------EMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKV-- 422
+ + +++ +G Y C A N G +R +L V P+
Sbjct: 1020 LISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKR--KVQLTVYVRPRVFGD 1077
Query: 423 TTVIQNPMPIR----EGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEP--------SLGVL 470
+ P+ G+ VTL C S P + W P G +
Sbjct: 1078 QRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI--ITWAKETQLISPFSPRHTFLPSGSM 1135
Query: 471 KIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQC 529
KI D+ C A N + V LNV P ++++ ++ G V + C
Sbjct: 1136 KITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP---KIQRGPKHLKVQVGQRVDIPC 1192
Query: 530 DFSSSHPKEVQFFWEKNGRLL---------GKESQLNFDSISPEDAGSYSCWVNNSIGQT 580
+ + P V W K G + + L+ D +P DAG Y+C N G T
Sbjct: 1193 N-AQGTPLPV-ITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAG-T 1249
Query: 581 ASKAWTLEVLYAP 593
TL V P
Sbjct: 1250 DETEITLHVQEPP 1262
Score = 75.1 bits (183), Expect = 3e-13
Identities = 115/488 (23%), Positives = 184/488 (37%), Gaps = 80/488 (16%)
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLK-----------DGTSLKKQNTFTLNLRE 298
P+D + G +VT+ C V PE T+ W + +S+ + T L +
Sbjct: 799 PADVSMEIGSNVTLPCYVQGY-PE-PTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILN 856
Query: 299 VTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLA- 357
+ G Y C+ N G +SE + + +EG Q+ C LA
Sbjct: 857 LWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAG 916
Query: 358 NPLPTNYTWYHNGKEMQG-----RTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAE 412
NP+P ++ +Q R++ +HI ++ G Y+CVA N+ GT +
Sbjct: 917 NPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVV 976
Query: 413 LDV----QYPPKKVTTVIQNPMPIREGDTVTLSCNYNSS-NPSVTRYEWKPHG------- 460
+ V Q+ + ++T+ EG VTL C + + PSV W G
Sbjct: 977 VHVLPTIQHGQQILSTI--------EGIPVTLPCKASGNPKPSVI---WSKKGELISTSS 1025
Query: 461 ----AWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPR---DVR-VRK 512
A + SL V + G ++ C A N+ V L V PR D R + +
Sbjct: 1026 AKFSAGADGSLYV--VSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQ 1083
Query: 513 IKPLS-EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKES---------QLNFDSIS 562
KP+ + +G V+L C+ S P + W K +L+ S +
Sbjct: 1084 DKPVEISVLAGEEVTLPCEVKSLPPPIIT--WAKETQLISPFSPRHTFLPSGSMKITETR 1141
Query: 563 PEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLTCESDAN 621
D+G Y C N G ++A L V P ++ P +V G+ + C +
Sbjct: 1142 TSDSGMYLCVATNIAG-NVTQAVKLNVHVPP---KIQRGPKHLKVQVGQRVDIPCNAQGT 1197
Query: 622 P-PVSHYTWFDWNNQSL---PYHSQK----LRLEPVKVQHSGAYWCQGTNSVGKGRSPLS 673
P PV TW + L +H L ++ +G Y C TN G + +
Sbjct: 1198 PLPV--ITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEI- 1254
Query: 674 TLTVYYSP 681
TL V P
Sbjct: 1255 TLHVQEPP 1262
Score = 73.6 bits (179), Expect = 7e-13
Identities = 106/497 (21%), Positives = 191/497 (38%), Gaps = 67/497 (13%)
Query: 209 QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVS 268
Q +H G+ TC ++A G + T+ + H P + I+ PS+ V + + + CE +
Sbjct: 3958 QLNHAGRY-TCVARNAAGSAHRHVTLHV---HEPPV-IQPQPSELHVILNNPILLPCEAT 4012
Query: 269 SSNPEYTTVSWLKDGTSLKKQN-------TFTLNLREVTKDQSGKYCCQVSNDVGPGRSE 321
+ + T W K+G ++ + L + ++ +G Y C N G +
Sbjct: 4013 GTPSPFIT--WQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGK 4070
Query: 322 EVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV 381
+ L VQ P S + AV+ + C + P P + TW+ +G+ + ++V
Sbjct: 4071 -IKLNVQVPPVISPHLKEYVIAVD-KPITLSCEADGLP-PPDITWHKDGRAIVESIRQRV 4127
Query: 382 ------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREG 435
I + P AG Y+C+A N+ G+ +L V PP+ +T + + E
Sbjct: 4128 LSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTS--TKLTVHVPPRIRST--EGHYTVNEN 4183
Query: 436 DTVTLSCNYNS-SNPSVTRYEWKPH--------GAWEEPSLGVLKIQNVGWDNTTI-ACA 485
L C + P++ WK G + G L ++NV +++ C
Sbjct: 4184 SQAILPCVADGIPTPAIN---WKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCV 4240
Query: 486 ACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK 545
A N+ V+L V P ++ ++ G + L C + ++ W
Sbjct: 4241 ANNAAGEDTHTVSLTVHVLPT---FTELPGDVSLNKGEQLRLSCKATGIPLPKLT--WTF 4295
Query: 546 NGRLL-------GKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRV 598
N ++ S+L + +S ED+G+Y C NS+G KA + P +
Sbjct: 4296 NNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFV--KAIGFVYVKEPPVFKG 4353
Query: 599 SMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYH---------SQKLRLEPV 649
G +A L CE +P + WN + + + L +
Sbjct: 4354 DYPSNWIEPLGGNAILNCEVKGDPTPT----IQWNRKGVDIEISHRIRQLGNGSLAIYGT 4409
Query: 650 KVQHSGAYWCQGTNSVG 666
+ +G Y C TN G
Sbjct: 4410 VNEDAGDYTCVATNEAG 4426
Score = 72.4 bits (176), Expect = 2e-12
Identities = 132/614 (21%), Positives = 223/614 (36%), Gaps = 76/614 (12%)
Query: 103 TLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPE---IQESQEVTL 159
++ I +DSG + + + LNV PP IQ P+ +Q Q V +
Sbjct: 1134 SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVH---VPPKIQRGPKHLKVQVGQRVDI 1190
Query: 160 TCLLNFSCYGYPIQ-LQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVT 218
C + G P+ + W G M S L I T
Sbjct: 1191 PC----NAQGTPLPVITWSKGGSTMLVDGEHHVSNP------DGTLSIDQATPSDAGIYT 1240
Query: 219 CQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVRE---GDSVTMTCEVSSSNPEYT 275
C + G + L+V+ P +E P + +E + C +
Sbjct: 1241 CVATNIAGT--DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKP-- 1296
Query: 276 TVSWLKDGTSLKK--------QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQV 327
T+ WL +G L ++ L + VT +G+Y C N+ G + L+V
Sbjct: 1297 TIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT-TERKYNLKV 1355
Query: 328 QYAPE-PSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKI 386
P Q+ + + C P P + N + + T + V+ KI
Sbjct: 1356 HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKI 1415
Query: 387 L------PWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTL 440
L P AG YSC A NI GT Q+ +DV PP + T N + + V L
Sbjct: 1416 LKLFRATPEDAGRYSCKAINIAGTSQK--YFNIDVLVPPTIIGTNFPNEVSVVLNRDVAL 1473
Query: 441 SCNYNSSN-PSVTRYEWKPHGAWEEPSL------GVLKIQNVGW-DNTTIACAACNSWCS 492
C + P + ++ +P++ VL ++N D C N+
Sbjct: 1474 ECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK 1533
Query: 493 WASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGK 552
A + L + Y P ++ + + + + L+C+ + W K+G+ +
Sbjct: 1534 QAKDIKLTI-YIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAIT--WYKDGQPIMS 1590
Query: 553 ESQ---------LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSP- 602
SQ L+ D+ +Y+C V N G TA K++ ++V Y P + +++
Sbjct: 1591 SSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAG-TAEKSFHVDV-YVPPMIEGNLATP 1648
Query: 603 -GDQVMEGKSATLTCESDANP-PVSHYTWFD-------WNNQSLPYHSQKLRLEPVKVQH 653
QV+ S TL C++ NP P+ TW +N + +KL + +
Sbjct: 1649 LNKQVVIAHSLTLECKAAGNPSPI--LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEID 1706
Query: 654 SGAYWCQGTNSVGK 667
G Y C T+ G+
Sbjct: 1707 RGQYICVATSVAGE 1720
Score = 68.2 bits (165), Expect = 3e-11
Identities = 108/465 (23%), Positives = 176/465 (37%), Gaps = 83/465 (17%)
Query: 265 CEVSSSNPEYTTVSWLKDGTSL------KKQNTFTLNLREVTKDQSGKYCCQVSNDVGPG 318
C V S P T+S++++G +L K+ + L++ +VT G Y C + G G
Sbjct: 451 CSVDSLLP--FTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTG 508
Query: 319 RSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTE 378
R++ F + P +Q+ ++ V + L + + + N TW N ++++
Sbjct: 509 RAQTFF---DVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEP 565
Query: 379 EKV--------HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPM 430
++ + + AG Y C+ + G L VQ PPK TV+
Sbjct: 566 ARIRTLANLSLELKSVKFNDAGEYHCMVSS--EGGSSAASVFLTVQEPPK--VTVMPKNQ 621
Query: 431 PIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW-------------EEPSLGVLKIQNVGW 477
G V++ C S T Y KP AW S G L I+N
Sbjct: 622 SFTGGSEVSIMC-------SATGYP-KPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAP 673
Query: 478 DNTTI-ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHP 536
+ I C A NS + L AP ++ ++ + G+ ++C S P
Sbjct: 674 KDAGIYGCLASNSAGTDKQNSTLRYIEAP---KLMVVQSELLVALGDITVMECKTSGIPP 730
Query: 537 KEVQFFWEKNGRLLGKESQLNFDSI---------SPEDAGSYSCWVNNSIGQTASKAWTL 587
+V+ W K L + L D + DAG Y+C N G+ K TL
Sbjct: 731 PQVK--WFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI-TL 787
Query: 588 EVLYAPRRLRVSMSPGDQVME-GKSATLTCESDANPPVSHYTWFDWNN-QSLPYHSQKLR 645
+V P ++ P D ME G + TL C P + W ++P S+
Sbjct: 788 DVGSPPVFIQ---EPADVSMEIGSNVTLPCYVQGYPEPT----IKWRRLDNMPIFSRPFS 840
Query: 646 LEPVKVQHSGA-------------YWCQGTNSVGKGRSPLSTLTV 677
+ + +GA Y C+ N GK +S +T+TV
Sbjct: 841 VSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSE-TTVTV 884
Score = 62.4 bits (150), Expect = 2e-09
Identities = 137/660 (20%), Positives = 239/660 (36%), Gaps = 115/660 (17%)
Query: 87 SEQKRVQFLGDKNKNCTLSIHPVHLNDSGQ---LGLRMESKTEKWMERIHLNVSERPFPP 143
S+ V+ L +K L I +DSG + ME K +K+ L++ P
Sbjct: 3195 SDSLEVRILSGGSK---LQIARSQHSDSGNYTCIASNMEGKAQKYY---FLSIQVPPSVA 3248
Query: 144 HIQLPPEIQE--SQEVTLTCLLNFSCYGYPIQL-QWLLEGVPMR-------QAAVTSTSL 193
++P ++ + V L C N G P L QWL +G P+ + + ++L
Sbjct: 3249 GAEIPSDVSVLLGENVELVCNAN----GIPTPLIQWLKDGKPIASGETERIRVSANGSTL 3304
Query: 194 TIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDA 253
I T K+ TC + G+ + LNV TP + ++
Sbjct: 3305 NIYGALTSDTGKY-----------TCVATNPAGE--EDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 254 IVREGD-SVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLN-----LREVTKDQS--G 305
++ D S+ + C + + P ++WLK+G L + L +R V S
Sbjct: 3352 LMTLVDTSINIECRATGTPPPQ--INWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVA 3409
Query: 306 KYCCQVSNDVGPGRSE---EVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362
Y C SN G +VF T +I ++GS C++ P P+
Sbjct: 3410 VYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEIT---VLKGSSTSMACITDGTPAPS 3466
Query: 363 NYTWYHNGKEM--QGRTEEKVH-----IPKILPWHAGTYSCVAENILGTGQRGPGAELDV 415
W +G+ + H + K +G Y+C+A N G+ L V
Sbjct: 3467 -MAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASN--EAGEVSKHFILKV 3523
Query: 416 QYPP--------KKVTTVIQNPMP---IREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEE 464
PP ++++ ++ NP+ I G P + + G E
Sbjct: 3524 LEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV 3583
Query: 465 PSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYA----PRDVRVRKIKPLSEIH 520
+ ++++ G + A + + V + A PRD+ V +
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR-------- 3635
Query: 521 SGNSVSLQCDFSSSHPKEVQFFWEKNG---------RLLGKESQLNFDSISPEDAGSYSC 571
V+L+C + P + W +NG R+L L ++ D +Y+C
Sbjct: 3636 -NRQVTLECKSDAVPPPVIT--WLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTC 3692
Query: 572 WVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQ---VMEGKSATLTCESDANPPVSHYT 628
+N G+T ++ + L V P ++ G Q ++ KS L C ++ P T
Sbjct: 3693 VASNIAGKT-TREFILTVNVPP-----NIKGGPQSLVILLNKSTVLECIAEG-VPTPRIT 3745
Query: 629 WFDWNNQSLPYHSQK-------LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP 681
W H++ L ++ V +G Y C TN+ G R + L V+ P
Sbjct: 3746 WRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRID-LQVHVPP 3804
Score = 59.7 bits (143), Expect = 1e-08
Identities = 141/627 (22%), Positives = 219/627 (34%), Gaps = 116/627 (18%)
Query: 104 LSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQE-----SQEVT 158
L + DSG+ ++ + + L V E PPHI E +E + +
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLE---PPHINGSEEHEEISVIVNNPLE 3547
Query: 159 LTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIV 217
LTC+ + G P ++ W+ +G P+ Q T L V S + + +
Sbjct: 3548 LTCIAS----GIPAPKMTWMKDGRPLPQTDQVQT-LGGGEVLRISTAQVEDT-GRYTCLA 3601
Query: 218 TCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTV 277
+ D D ++L V N+ T + P D V VT+ C+ + P +
Sbjct: 3602 SSPAGDDDKEYLVRVHVPPNIAGTDE------PRDITVLRNRQVTLECKSDAVPPP--VI 3653
Query: 278 SWLKDGTSLKKQNTFT-------LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFL----- 325
+WL++G L+ L + + Y C SN G E +
Sbjct: 3654 TWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPP 3713
Query: 326 QVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEK----- 380
++ P+ + + S +E C++ P P TW +G + G
Sbjct: 3714 NIKGGPQSLVILLNKSTVLE-------CIAEGVPTP-RITWRKDGAVLAGNHARYSILEN 3765
Query: 381 --VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNP--MPIREGD 436
+HI G Y C+A N GT +R +L V PP ++ P M +
Sbjct: 3766 GFLHIQSAHVTDTGRYLCMATNAAGTDRR--RIDLQVHVPP----SIAPGPTNMTVIVNV 3819
Query: 437 TVTLSCNYNS-SNPSVTRYEWKPHG----------AWEEPSLGVLKIQNVGWDNT-TIAC 484
TL+C PS+ W+ +G ++ S G L I + D+T T C
Sbjct: 3820 QTTLACEATGIPKPSI---NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876
Query: 485 AACNSWCSWASPVALNVQY------APRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKE 538
N V L VQ P D V K P + + V F S H
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGV----PFPSIH--- 3929
Query: 539 VQFFWEKNG-RLLGK--------ESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEV 589
W KNG RLL + + + AG Y+C N+ G +A + TL V
Sbjct: 3930 ----WTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAG-SAHRHVTLHV 3984
Query: 590 LYAPRRLRVSMSPGD-QVMEGKSATLTCESDANPPVSHYTW---------FDWNNQSLPY 639
P + P + V+ L CE+ P TW N+ LP
Sbjct: 3985 HEPP---VIQPQPSELHVILNNPILLPCEATGTPS-PFITWQKEGINVNTSGRNHAVLP- 4039
Query: 640 HSQKLRLEPVKVQHSGAYWCQGTNSVG 666
S L++ + +G Y C N G
Sbjct: 4040 -SGGLQISRAVREDAGTYMCVAQNPAG 4065
Score = 41.2 bits (95), Expect = 0.004
Identities = 62/265 (23%), Positives = 102/265 (38%), Gaps = 36/265 (13%)
Query: 218 TCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTV 277
TC +A G+ TV L V P P D + +G+ + ++C+ + +
Sbjct: 4238 TCVANNAAGE--DTHTVSLTVHVLPTFT--ELPGDVSLNKGEQLRLSCKATGI--PLPKL 4291
Query: 278 SWLKDGTSLKKQ-----NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPE 332
+W + + L + V+K+ SG Y C N VG ++ + Y E
Sbjct: 4292 TWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKA----IGFVYVKE 4347
Query: 333 PSTVQILH-SPAVE--GSQVEFLCMSLANPLPTNYTWYHNGK--EMQGRTEE----KVHI 383
P + + S +E G C +P PT W G E+ R + + I
Sbjct: 4348 PPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIEISHRIRQLGNGSLAI 4406
Query: 384 PKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCN 443
+ AG Y+CVA N G +R L +Q PP + T+ I G + L+C
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVER--SMSLTLQSPP--IITLEPVETVINAGGKIILNCQ 4462
Query: 444 YNSS-NPSVTRYEWKPHG---AWEE 464
P++T W G +W++
Sbjct: 4463 ATGEPQPTIT---WSRQGHSISWDD 4484
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 103 bits (257), Expect = 7e-22
Identities = 112/452 (24%), Positives = 179/452 (39%), Gaps = 44/452 (9%)
Query: 245 EIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF---TLNLREVTK 301
+++ ++ V G + T+ C + S T+ W K + L Q+ TL + V +
Sbjct: 3213 QVQAEEAELTVEAGHTATLRCSATGSPAP--TIHWSKLRSPLPWQHRLEGDTLIIPRVAQ 3270
Query: 302 DQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLP 361
SG+Y C ++ G + + L V+ P +TV H+ G V+ C++ P P
Sbjct: 3271 QDSGQYICNATSPAGHAEAT-IILHVESPPYATTVPE-HASVQAGETVQLQCLAHGTP-P 3327
Query: 362 TNYTWYHNGKEMQGRT---EEKVHIPKILPWHAGTYSCVAENILGTGQ-------RGPGA 411
+ W G + GR E +H + P +G Y C N +G+ + +GP
Sbjct: 3328 LTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
Query: 412 ELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV--TRYEWKPHGAWEEPSL-- 467
L P T +Q P E ++ S ++ + PS T+ W G P
Sbjct: 3388 SLPATSIPAGSTPTVQ-VTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV 3446
Query: 468 --GVLKIQNVGWD-NTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNS 524
GVL+IQN+ T C A W + L +Q P V + + + G++
Sbjct: 3447 QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALP-SVLINIRTSVQTVVVGHA 3505
Query: 525 VSLQCDFSSSHPKEVQFFWEKNGR-----LLGKESQLNFDSISPEDAGSYSCWVNNSIGQ 579
V +C + PK Q W K G ++ + + DAG Y C N+ G
Sbjct: 3506 VEFEC-LALGDPKP-QVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGT 3563
Query: 580 TASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPY 639
T S +L ++SM +V G +A C + P +W + SLP
Sbjct: 3564 TQSHV----LLLVQALPQISMPQEVRVPAGSAAVFPCIASGYP-TPDISWSKLDG-SLPP 3617
Query: 640 HSQ----KLRLEPVKVQHSGAYWCQGTNSVGK 667
S+ L L V+ Q +G Y C TN GK
Sbjct: 3618 DSRLENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Score = 95.1 bits (235), Expect = 2e-19
Identities = 157/692 (22%), Positives = 269/692 (38%), Gaps = 113/692 (16%)
Query: 104 LSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSER---PFPPHIQLPPEIQ-------E 153
L +H + + DSG+ R + + I ++VS P P +P I+ E
Sbjct: 2681 LRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE 2740
Query: 154 SQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTS-LTIKSVFTRSELKFSPQWSH 212
+ + L C++ + Q+ W G + T S L + V SP S
Sbjct: 2741 GETLDLNCVVPGQAHA---QVTWHKRGGSLPSHHQTRGSRLRLHHV--------SPADS- 2788
Query: 213 HGKIVTCQLQDADGKFLSNDTVQLNVK-----HTPKL----EIKVTPSDAIVREGDSVTM 263
G+ V C++ + G ++ V + H P I++ PS + V EG ++ +
Sbjct: 2789 -GEYV-CRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDL 2846
Query: 264 TCEVSSSNPEYTTVSWLKDGTSLKKQNTF---TLNLREVTKDQSGKYCCQVSNDVGPGRS 320
C V + V+W K G +L ++ L L +V+ SG+Y CQV+ G +
Sbjct: 2847 KCVVPGQ--AHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEA 2904
Query: 321 EEVFLQVQYAP---------EPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGK 371
+ +P +P ++ S EG ++ C+ + TWY G
Sbjct: 2905 SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCV-VPGQAHAQVTWYKRGG 2963
Query: 372 EMQGRTE---EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQY----PPKK--- 421
+ R + ++ + + P +G Y C A + GPG E + + PP +
Sbjct: 2964 SLPARHQTHGSQLRLHLVSPADSGEYVCRAAS-------GPGPEQEASFTVTVPPSEGSS 3016
Query: 422 ------VTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEE------PSLGV 469
V ++ +++G + C + ++ EWK E P+ +
Sbjct: 3017 YRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPIS-LEWKTRNQELEDNVHISPNGSI 3075
Query: 470 LKIQNVGWDN-TTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQ 528
+ I N T C A N++ S V L+V + P V V P+ + G +V+L+
Sbjct: 3076 ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV-HGPPTVSVLPEGPV-WVKVGKAVTLE 3133
Query: 529 CDFS------------SSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNS 576
C + SS P +++ ++ L+ + L S P DAG+Y C N+
Sbjct: 3134 CVSAGEPRSSARWTRISSTPAKLE---QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNA 3190
Query: 577 IGQTASKAWTLEV---LYAPRRLRVSMSPGDQVME-GKSATLTCESDANP-PVSHYTWFD 631
+G TA K + V AP +V + +E G +ATL C + +P P H++
Sbjct: 3191 LG-TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKL- 3248
Query: 632 WNNQSLPY----HSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP--ETIG 685
LP+ L + V Q SG Y C T+ G + + L V P T+
Sbjct: 3249 --RSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATI-ILHVESPPYATTVP 3305
Query: 686 RRVAVGLGSCLAILILAICGLKLQRRWKRTQS 717
+V G + + LA L +W R S
Sbjct: 3306 EHASVQAGETVQLQCLAHGTPPLTFQWSRVGS 3337
Score = 90.5 bits (223), Expect = 6e-18
Identities = 145/597 (24%), Positives = 231/597 (38%), Gaps = 99/597 (16%)
Query: 142 PPHIQLP---PEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMR-QAAVTSTSLTIKS 197
PP +++ P + E Q + L C++ S + Q+ W G + V + L +
Sbjct: 2050 PPPVKIESSSPSVTEGQTLDLNCVVAGSAHA---QVTWYRRGGSLPPHTQVHGSRLRLPQ 2106
Query: 198 VFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQL------NVKHTP----KLEIK 247
V SP S G+ V C++++ G ++ TV + +TP I+
Sbjct: 2107 V--------SPADS--GEYV-CRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIR 2155
Query: 248 VTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF---TLNLREVTKDQS 304
+ PS + V EG ++ + C V + V+W K G SL ++ L L +VT S
Sbjct: 2156 IEPSSSHVAEGQTLDLNCVVPGQ--AHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADS 2213
Query: 305 GKYCCQVSNDVGP-GRSEEVFLQVQYAP---EPSTVQILHSPAVEGSQVEFLCMSLANPL 360
G+Y C V GP S V ++ P P ++ S EG ++ C+ +A
Sbjct: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCV-VAGQA 2272
Query: 361 PTNYTWYHNGKEMQGRTE---EKVHIPKILPWHAGTYSCVAEN-------ILGTGQRGPG 410
TWY G + R + +++I + P AG Y C A N + TG +G
Sbjct: 2273 HAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQG-- 2330
Query: 411 AELDVQYPPKKVTTVIQNP--MPIREGDTVTLSCNY-NSSNPSVTRYEWKPHG----AWE 463
++ YP + P + EG T+ L+C S+ VT W G
Sbjct: 2331 --ANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT---WHKRGGSLPVRH 2385
Query: 464 EPSLGVLKI-QNVGWDNTTIACAACNSWCSWASPVALNVQYAPR------DVRVRKIKPL 516
+ +L++ Q D+ C S + V + ++ A VR
Sbjct: 2386 QTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSS 2445
Query: 517 SEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKE-----SQLNFDSISPEDAGSYSC 571
S++ G ++ L C + Q W K G L S+L ++P D+G Y C
Sbjct: 2446 SQVAEGQTLDLNCLVAGQ--AHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVC 2503
Query: 572 WVNNSIG-QTASKAWTLEVLYAPRRLRVSMSPG-----------DQVMEGKSATLTCESD 619
V S G Q AS T++ +RL S S G + G + L C
Sbjct: 2504 RVVGSSGTQEASVLVTIQ-----QRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVA 2558
Query: 620 ANPPVSHYTWFDWNNQSLPYHSQ----KLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672
+ P + TW+ SLP Q +LR+ V SG Y C +N G + L
Sbjct: 2559 SQAPHT-ITWYK-RGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSL 2613
Score = 89.4 bits (220), Expect = 1e-17
Identities = 122/494 (24%), Positives = 195/494 (39%), Gaps = 82/494 (16%)
Query: 246 IKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT---LNLREVTKD 302
+++ S A + G ++ + C V+S P T++W K G SL ++ L + +VT
Sbjct: 2536 VRIESSSASLANGHTLDLNCLVASQAPH--TITWYKRGGSLPSRHQIVGSRLRIPQVTPA 2593
Query: 303 QSGKYCCQVSNDVGPGRSEEVFLQVQ-----YAPE---PSTVQILHSPAVEGSQVEFLCM 354
SG+Y C VSN G R + + +Q + P P ++ VEG ++ C+
Sbjct: 2594 DSGEYVCHVSNGAG-SRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652
Query: 355 SLANPLPTNYTWYHNGKEMQGRTE---EKVHIPKILPWHAGTYSCVAENILGTGQRGPGA 411
P TWY G + R + + + ++ +G Y C A N + + A
Sbjct: 2653 VARQP-QAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALE----A 2707
Query: 412 ELDVQYPPKKVT-TVIQNPMPIR---------EGDTVTLSCNY-NSSNPSVTRYEWKPHG 460
+ + P + + + MPIR EG+T+ L+C ++ VT W G
Sbjct: 2708 SIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT---WHKRG 2764
Query: 461 ----AWEEPSLGVLKIQNVG-WDNTTIACAACNSWCSWASPVALNVQY---------APR 506
+ + L++ +V D+ C S + V + ++ AP
Sbjct: 2765 GSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPG 2824
Query: 507 DVRVRKIKP-LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-----LNFDS 560
+I+P S + G ++ L+C Q W K G L Q L +
Sbjct: 2825 GAPPIRIEPSSSRVAEGQTLDLKCVVPGQ--AHAQVTWHKRGGNLPARHQVHGPLLRLNQ 2882
Query: 561 ISPEDAGSYSCWVNNSIGQ-TASKAWTLEV----------LYAPRRLRVSMSPGDQVMEG 609
+SP D+G YSC V S G AS T+E L P + S S V EG
Sbjct: 2883 VSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS---HVTEG 2939
Query: 610 KSATLTCESDANPPVSH--YTWFDWNNQSLP----YHSQKLRLEPVKVQHSGAYWCQGTN 663
++ L C P +H TW+ SLP H +LRL V SG Y C+ +
Sbjct: 2940 QTLDLNC---VVPGQAHAQVTWYK-RGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAAS 2995
Query: 664 SVGKGRSPLSTLTV 677
G + T+TV
Sbjct: 2996 GPGPEQEASFTVTV 3009
Score = 85.5 bits (210), Expect = 2e-16
Identities = 120/492 (24%), Positives = 196/492 (39%), Gaps = 53/492 (10%)
Query: 228 FLSNDTVQ----LNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKD- 282
++ N +VQ L + L ++V P+ +IV +G S ++ C+VS S P Y W ++
Sbjct: 1657 YVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHY--FYWSRED 1714
Query: 283 ------GTSLKKQNTFTLNLREVTKDQSGKYCCQVSN--DVGPGRSEEVFLQVQYAPEPS 334
GT + Q + L+ V +G Y C N R+E + + P
Sbjct: 1715 GRPVPSGTQQRHQGS-ELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITV 1773
Query: 335 TVQILHSPAVE-GSQVEFLCMSLANPLPTNYTW--YHNGKEMQGRTEEK--VHIPKILPW 389
TV+ S +V G+ V F+C + + W HNGK + + I +
Sbjct: 1774 TVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLS 1833
Query: 390 HAGTYSCVAENILGTGQRGPGAELDVQYP---PKKVTTVIQNPMPIREGDTVTLSCNYNS 446
AGTY C N+ Q A L VQ V ++ + ++ G C+
Sbjct: 1834 DAGTYVCTGSNMFAMDQ--GTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATG 1891
Query: 447 SNPSVTRYEWKPHG---AWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQ 502
S + P G A + G+L++ V D C A +S + L+V
Sbjct: 1892 SPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHV- 1950
Query: 503 YAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ------- 555
+ RV+ +++H+G +V L C ++ W K G L +++
Sbjct: 1951 HGGGGPRVQVSPERTQVHAGRTVRLYC--RAAGVPSATITWRKEGGSLPPQARSERTDIA 2008
Query: 556 -LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYA----PRRLRVSMSPGDQVMEGK 610
L +I+ DAG Y C + G TA + VL A P +++ S V EG+
Sbjct: 2009 TLLIPAITTADAGFYLCVATSPAG-TAQARIQVVVLSASDASPPPVKIE-SSSPSVTEGQ 2066
Query: 611 SATLTCESDANPPVSHYTWFDWNNQSLPYHSQ----KLRLEPVKVQHSGAYWCQGTNSVG 666
+ L C A + TW+ SLP H+Q +LRL V SG Y C+ N G
Sbjct: 2067 TLDLNCVV-AGSAHAQVTWYR-RGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG 2124
Query: 667 KGRSPLSTLTVY 678
+ ++ ++
Sbjct: 2125 PKEASITVSVLH 2136
Score = 82.4 bits (202), Expect = 2e-15
Identities = 122/513 (23%), Positives = 191/513 (37%), Gaps = 56/513 (10%)
Query: 246 IKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT----- 300
I + P + V++G + C + + + W L+ + N +T
Sbjct: 3024 ISIDPPSSTVQQGQDASFKCLIHDGAAPIS-LEWKTRNQELEDNVHISPNGSIITIVGTR 3082
Query: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV---EGSQVEFLCMSLA 357
G Y C SN G +S V L V P TV +L V G V C+S
Sbjct: 3083 PSNHGTYRCVASNAYGVAQSV-VNLSVH---GPPTVSVLPEGPVWVKVGKAVTLECVSAG 3138
Query: 358 NPLPTNYTWYHNGK---EMQGRT------EEKVHIPKILPWHAGTYSCVAENILGTGQRG 408
P ++ W +++ RT + I P AGTY C+A+N LGT Q+
Sbjct: 3139 EPR-SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQ 3197
Query: 409 PGAELDV--QYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSN-PSVTRYEWKPHGAWEEP 465
+D P + + + G T TL C+ S P++ + + W+
Sbjct: 3198 VEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR 3257
Query: 466 SLG-VLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGN 523
G L I V D+ C A + + + L+V+ P V + + + +G
Sbjct: 3258 LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEH---ASVQAGE 3314
Query: 524 SVSLQCDFSSSHPKEVQFFWEK-----NGRLLGKESQLNFDSISPEDAGSYSCWVNNSIG 578
+V LQC + P + F W + GR + L+F+ +PED+G Y C V N +G
Sbjct: 3315 TVQLQCLAHGTPP--LTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVG 3372
Query: 579 QTASKAWTLEVLYAPRRLRVSMSPGDQV--------MEGKSATLTCESDANPPVSHYT-- 628
+ A L V P L + P +E KS + E P T
Sbjct: 3373 SAEAFAQLL-VQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQL 3431
Query: 629 -WFDWNNQSLPYHSQK---LRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETI 684
WF Q P HS + LR++ + G Y CQ GK ++ + I
Sbjct: 3432 RWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLI 3491
Query: 685 GRRVAVG---LGSCLAILILAICGLKLQRRWKR 714
R +V +G + LA+ K Q W +
Sbjct: 3492 NIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK 3524
Score = 82.4 bits (202), Expect = 2e-15
Identities = 110/443 (24%), Positives = 180/443 (40%), Gaps = 60/443 (13%)
Query: 183 MRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDT--------- 233
+R +A S + TI RS L + + I+ Q G+++ N T
Sbjct: 3231 LRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEAT 3290
Query: 234 VQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT 293
+ L+V+ P P A V+ G++V + C + P T W + G+SL + T
Sbjct: 3291 IILHVESPPYAT--TVPEHASVQAGETVQLQCLAHGTPP--LTFQWSRVGSSLPGRATAR 3346
Query: 294 ---LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEP-----------STVQIL 339
L+ + SG+Y C+V+N VG S E F Q+ P ST +
Sbjct: 3347 NELLHFERAAPEDSGRYRCRVTNKVG---SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQ 3403
Query: 340 HSPAVE----GSQVEFLCMSLANPLPTNYTWYHNGKEMQ-GRTEEK--VHIPKILPWHAG 392
+P +E G+ VEF C ++ + T W+ G ++ G + + + I + G
Sbjct: 3404 VTPQLETKSIGASVEFHC-AVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQG 3462
Query: 393 TYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSC-NYNSSNPSV 451
TY C A G Q A+L +Q P + + + + G V C P V
Sbjct: 3463 TYICQAHGPWGKAQAS--AQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQV 3520
Query: 452 TRYEWKPHGAWEEPSL----GVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPR 506
T W G P + GV++I +V D C A N+ + S V L VQ P+
Sbjct: 3521 T---WSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ 3577
Query: 507 DVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLN-----FDSI 561
++++ + +G++ C +S +P W K L +S+L S+
Sbjct: 3578 ISMPQEVR----VPAGSAAVFPC-IASGYPTP-DISWSKLDGSLPPDSRLENNMLMLPSV 3631
Query: 562 SPEDAGSYSCWVNNSIGQTASKA 584
P+DAG+Y C N G+ + A
Sbjct: 3632 RPQDAGTYVCTATNRQGKVKAFA 3654
Score = 71.6 bits (174), Expect = 3e-12
Identities = 132/597 (22%), Positives = 224/597 (37%), Gaps = 68/597 (11%)
Query: 148 PPE--IQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAA-VTSTSLTIKSVFTRSEL 204
PP +Q+ Q+ + CL++ PI L+W + ++ I V TR
Sbjct: 3028 PPSSTVQQGQDASFKCLIHDGAA--PISLEWKTRNQELEDNVHISPNGSIITIVGTRP-- 3083
Query: 205 KFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAI-VREGDSVTM 263
S+HG C +A G ++ V L+V P + V P + V+ G +VT+
Sbjct: 3084 ------SNHGTY-RCVASNAYG--VAQSVVNLSVHGPPT--VSVLPEGPVWVKVGKAVTL 3132
Query: 264 TCEVSSSNPEYTTVSWLKDGTSLKK--QNTF-------TLNLREVTKDQSGKYCCQVSND 314
C VS+ P ++ W + ++ K Q T+ L + +G Y C N
Sbjct: 3133 EC-VSAGEPR-SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNA 3190
Query: 315 VGPGRSEEVFLQVQYAPEPSTVQILHSPA---VEGSQVEFL-CMSLANPLPT-NYTWYHN 369
+G + + + A P Q+ A VE L C + +P PT +++ +
Sbjct: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRS 3250
Query: 370 GKEMQGRTE-EKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQN 428
Q R E + + IP++ +G Y C A + G + L V+ PP T +
Sbjct: 3251 PLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEAT--IILHVESPP--YATTVPE 3306
Query: 429 PMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGW------DNTTI 482
++ G+TV L C + + P ++W G+ P + + + + D+
Sbjct: 3307 HASVQAGETVQLQCLAHGTPPLT--FQWSRVGS-SLPGRATARNELLHFERAAPEDSGRY 3363
Query: 483 ACAACNSWCSWASPVALNVQYAPRDVRVRKIK----------PLSEIHS-GNSVSLQCDF 531
C N S + L VQ P + I P E S G SV C
Sbjct: 3364 RCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAV 3423
Query: 532 SSSHPKEVQFFWEKNGRLLGKESQ---LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLE 588
S ++++F E G Q L ++ G+Y C + G+ + A L
Sbjct: 3424 PSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASA-QLV 3482
Query: 589 VLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQK---LR 645
+ P L + V+ G + C + +P TW P Q +R
Sbjct: 3483 IQALPSVLINIRTSVQTVVVGHAVEFECLALGDPK-PQVTWSKVGGHLRPGIVQSGGVVR 3541
Query: 646 LEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILA 702
+ V++ +G Y C TN+ G +S + L ++ + V V GS +A
Sbjct: 3542 IAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIA 3598
>gi|4502659 sialic acid binding Ig-like lectin 5 [Homo sapiens]
Length = 551
Score = 99.0 bits (245), Expect = 2e-20
Identities = 107/434 (24%), Positives = 176/434 (40%), Gaps = 53/434 (12%)
Query: 6 PWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYN 65
P LLL +L + + + + +++ EG CV +PC++ S + +
Sbjct: 3 PLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFR 62
Query: 66 KNTSKFDGTRLYESTKDGKV-PSEQKRVQFLGD-KNKNCTLSIHPVHLNDSGQLGLRMES 123
+ + + D +V P Q R + LGD + KNC+LSI + D+G R+E
Sbjct: 63 DGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVER 122
Query: 124 ----KTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCY-GYPIQLQWLL 178
K +++L V+ P I ++ + L+C L SC G P+ W
Sbjct: 123 GRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTG 182
Query: 179 EGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNV 238
+ T +S EL +P+ HG +TCQ++ + + TVQLNV
Sbjct: 183 NALSPLDPETTRSS----------ELTLTPRPEDHGTNLTCQMKRQGAQVTTERTVQLNV 232
Query: 239 KHTPK----------LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK 288
+ P+ LEI S V EG ++ + C+ S+ P + +SW + +L
Sbjct: 233 SYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPPAH--LSWFQGSPALNA 290
Query: 289 ---QNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVE 345
NT L LR V + G + C+ + +G ++FL + P + S E
Sbjct: 291 TPISNTGILELRRVRSAEEGGFTCRAQHPLG---FLQIFLNLSVYSLPQLLGPSCSWEAE 347
Query: 346 GSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEE---KVHIPKILPW-------HAG--- 392
G + C A P P + W K ++G + + KV+ PW H G
Sbjct: 348 G--LHCRCSFRARPAP-SLCWRLEEKPLEGNSSQGSFKVNSSSAGPWANSSLILHGGLSS 404
Query: 393 --TYSCVAENILGT 404
SC A NI G+
Sbjct: 405 DLKVSCKAWNIYGS 418
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/195 (24%), Positives = 81/195 (41%), Gaps = 31/195 (15%)
Query: 516 LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG-------KESQLNFDSISPEDAGS 568
L + SG L C S + G L + S+L PED G+
Sbjct: 151 LEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTP-RPEDHGT 209
Query: 569 -YSCWVNNSIGQ-TASKAWTLEVLYAPRRLRV-------------SMSPGDQVMEGKSAT 613
+C + Q T + L V YAP+ + + S P V+EG++
Sbjct: 210 NLTCQMKRQGAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLP---VLEGQALR 266
Query: 614 LTCESDANPPVSHYTWFDWN---NQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRS 670
L C++ +NPP +H +WF + N + ++ L L V+ G + C+ + +G +
Sbjct: 267 LLCDAPSNPP-AHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQI 325
Query: 671 PLSTLTVYYSPETIG 685
L+ L+VY P+ +G
Sbjct: 326 FLN-LSVYSLPQLLG 339
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 97.4 bits (241), Expect = 5e-20
Identities = 111/462 (24%), Positives = 186/462 (40%), Gaps = 63/462 (13%)
Query: 248 VTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN-------TFTLNLREVT 300
V + V G++ ++C V P T W++D L +L + +
Sbjct: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLADLSLEISGII 461
Query: 301 KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL 360
G+Y C SN G R+ V+L V+ AP+ S + +G +V+ C + P
Sbjct: 462 PTDGGRYQCVASNANGVTRAS-VWLLVREAPQVS-IHTSSQHFSQGVEVKVSCSASGYPT 519
Query: 361 PTNYTWYHNGKEMQGRTEEKVHIPK--------ILPWHAGTYSCVAENILGTGQRGPGAE 412
P + +W + +Q + ++H+ + P AG YSC A N +GT Q
Sbjct: 520 P-HISWSRESQALQ--EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQE----T 572
Query: 413 LDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHG-----AWEEPSL 467
+ + Y + + + + G+ L C + P R W G A E S
Sbjct: 573 VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP--RVIWYRGGLEMILAPEGSSS 630
Query: 468 GVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVS 526
G L+I D T C A N ++ + L V +AP+ + ++ + G S
Sbjct: 631 GKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQ---LTELPRDVTVELGRSAL 687
Query: 527 LQCDFSSSHPKEVQFFWEK-NGRLLG--------------KESQLNFDSISPEDAGSYSC 571
L C + P V W + +G+ LG L F+S++PED Y C
Sbjct: 688 LACRATGRPPPTVT--WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVC 745
Query: 572 WVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFD 631
N G+ ++A + +AP ++ S +P +V+EG+ +L C A P+ W
Sbjct: 746 EARNVFGKVQAEARLIVTGHAPPQI-ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLK 804
Query: 632 WNNQSLPYHSQ-------KLRLEPVKVQHSGAYWCQGTNSVG 666
+ + LP S+ L L+ +H+G Y C TN+ G
Sbjct: 805 -DGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845
Score = 86.7 bits (213), Expect = 8e-17
Identities = 126/529 (23%), Positives = 192/529 (36%), Gaps = 70/529 (13%)
Query: 103 TLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCL 162
TL I V D+G + ++ E + L ++ P + + +E L C
Sbjct: 544 TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC- 602
Query: 163 LNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQL 221
G P ++ W G+ M A S+S +L+ TC+
Sbjct: 603 ---EASGVPPPRVIWYRGGLEMILAPEGSSS---------GKLRIPAAQERDAGTYTCRA 650
Query: 222 QDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLK 281
+ G ++ +QL V H P+L P D V G S + C + P TV+W +
Sbjct: 651 VNELGD--ASAEIQLAVGHAPQLT--ELPRDVTVELGRSALLACRATGRPPP--TVTWRR 704
Query: 282 D-------------GTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQ 328
G+ ++ ++ L V + Y C+ N G ++E +
Sbjct: 705 GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG 764
Query: 329 YAPEPSTVQILHSPAVEGSQVEFLCMSLAN-PLPTNYTWYHNGKEMQG------RTEEKV 381
+AP +EG V C+ LA PLP + W +G+ + R + +
Sbjct: 765 HAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADGSL 823
Query: 382 HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLS 441
H+ + L HAG YSCVA N G+ R EL VQ PP+ T + EG +L
Sbjct: 824 HLDRALQEHAGRYSCVATNTAGSQHR--DVELVVQVPPRIHPTATHH--ITNEGVPASLP 879
Query: 442 CNYNSSNPSVTRYEWKPHGAWEE--PSLGVLK------IQNVGWDNTTIACAACNSWCSW 493
C S P+ T K A P V K Q D C A N+
Sbjct: 880 C-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFS 938
Query: 494 ASPVALNVQYAPR----DVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRL 549
+ + L+V PR R + +G V+L C+ S P V W K+ R
Sbjct: 939 SQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVT--WTKDSRP 996
Query: 550 ---------LGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEV 589
L L + D+G Y C +N G +AS + L V
Sbjct: 997 VPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG-SASHRYVLGV 1044
Score = 81.3 bits (199), Expect = 4e-15
Identities = 144/635 (22%), Positives = 228/635 (35%), Gaps = 93/635 (14%)
Query: 85 VPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPH 144
+P+ RV L D +L I + D G+ + + L V E P
Sbjct: 440 LPASTGRVAQLAD----LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSI 495
Query: 145 IQLPPEIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSE 203
+ EV ++C S GYP + W E QA + + + + T
Sbjct: 496 HTSSQHFSQGVEVKVSC----SASGYPTPHISWSRES----QALQEDSRIHVDAQGTLII 547
Query: 204 LKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTM 263
+P+ + + +CQ + G D + + +T + + +V G+ +
Sbjct: 548 QGVAPEDAGN---YSCQATNEVG----TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVL 600
Query: 264 TCEVSSSNPEYTTVSWLKDGTSL----KKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGR 319
CE S P V W + G + + ++ L + + +G Y C+ N++G
Sbjct: 601 VCEASGVPPP--RVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA- 657
Query: 320 SEEVFLQVQYAPEPSTVQILHSPAVE-GSQVEFLCMSLANPLPTNYTWYHN--------- 369
S E+ L V +AP+ ++ VE G C + P PT TW
Sbjct: 658 SAEIQLAVGHAPQ--LTELPRDVTVELGRSALLACRATGRPPPT-VTWRRGDGQPLGLRL 714
Query: 370 --GKEMQGRTEEK--VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTV 425
G+ + R + + + P Y C A N+ G Q + PP+ ++
Sbjct: 715 GAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSA 774
Query: 426 IQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSL-------GVLKIQNVGWD 478
+ + EG V+L C + P R+ W G P G L + +
Sbjct: 775 --PTVRVLEGQPVSLPCIVLAGRPLPERH-WLKDGRPLPPGSRHSIRADGSLHLDRALQE 831
Query: 479 NT-TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNS---VSLQCDFSSS 534
+ +C A N+ S V L VQ PR I P + H N SL C S
Sbjct: 832 HAGRYSCVATNTAGSQHRDVELVVQVPPR------IHPTATHHITNEGVPASLPCVASGV 885
Query: 535 HPKEVQFFWEKNGRL-------LGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTL 587
+ + E N + KE L S +DAG+Y C N++G +S+ L
Sbjct: 886 PAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG-FSSQEMRL 944
Query: 588 EVLYAPRRLRVSMSPGDQV------MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYH- 640
V PR + ++ S V G+ TL CE+ +PP W S P
Sbjct: 945 SVNTKPR-IHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPP----PLVTWTKDSRPVPP 999
Query: 641 ---------SQKLRLEPVKVQHSGAYWCQGTNSVG 666
S LRL V+V SG Y C +N G
Sbjct: 1000 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
Score = 76.3 bits (186), Expect = 1e-13
Identities = 84/348 (24%), Positives = 142/348 (40%), Gaps = 35/348 (10%)
Query: 392 GTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSV 451
GTY C A + GTG+ A++ V PP ++ + + G+T LSC P
Sbjct: 375 GTYECTAVSRAGTGRAK--AQIVVTDPPPQLVPAPN--VTVSPGETAVLSCRVLGEAPYN 430
Query: 452 TRY--EWK--PHGAWEEPSLGVLKIQNVG---WDNTTIACAACNSWCSWASPVALNVQYA 504
+ +W+ P L L ++ G D C A N+ + V L V+ A
Sbjct: 431 LTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA 490
Query: 505 PRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDS---- 560
P+ V + S H V ++ S+S W + + L ++S+++ D+
Sbjct: 491 PQ-VSIHT----SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTL 545
Query: 561 ----ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTC 616
++PEDAG+YSC N +G T+ + Y +++ V G+ A L C
Sbjct: 546 IIQGVAPEDAGNYSCQATNEVGTDQE---TVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 602
Query: 617 ESDANPPVSHYTWFDWNNQSL----PYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL 672
E+ PP W+ + + S KLR+ + + +G Y C+ N +G + +
Sbjct: 603 EASGVPP-PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEI 661
Query: 673 STLTVYYSPE--TIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQ 718
L V ++P+ + R V V LG + A W+R Q
Sbjct: 662 Q-LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
>gi|205830470 sialic acid binding Ig-like lectin 11 isoform 1 [Homo
sapiens]
Length = 698
Score = 94.7 bits (234), Expect = 3e-19
Identities = 105/454 (23%), Positives = 175/454 (38%), Gaps = 61/454 (13%)
Query: 36 EGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVP-SEQKRVQF 94
EG CV + C + + + TS G + + + +V S + R Q
Sbjct: 46 EGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQL 105
Query: 95 LGDKNK-NCTLSIHPVHLNDSGQLGLRMESKTEK----WMERIHLNVSERPFPPHIQLPP 149
GD K +C+L I D R+E + L V+ P + +P
Sbjct: 106 TGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPE 165
Query: 150 EIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSP 208
++ Q VT+ C+ N++ P W A S T S S L F+P
Sbjct: 166 TLEPGQPVTVICVFNWAFKKCPAPSFSWT--------GAALSPRRTRPSTSHFSVLSFTP 217
Query: 209 QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-------------LEIKVTPSDAIV 255
H +TC + + + TV+L V + PK LE++ V
Sbjct: 218 SPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEV 277
Query: 256 REGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN-----TFTLNLREVTKDQSGKYCCQ 310
++G + + C S P T+SW+ L + T L LR V SG+Y C+
Sbjct: 278 QKGQFLRLLCAADSQPP--ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCR 335
Query: 311 VSNDVGPGRSEEVFLQVQYAPEPSTVQILHS--------------PAVEGSQVEFLCMSL 356
N +G + + + L VQY PE V + + P +EG + +C++
Sbjct: 336 AENRLG-SQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTH 394
Query: 357 ANPLPTNYTWYHNGKEM---QGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAEL 413
++P P +W G+ + Q + +P I H G ++C A++ LG+ + L
Sbjct: 395 SSP-PARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGS--QHVSLSL 451
Query: 414 DVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSS 447
V YPP+ + P E + + SC+ +S
Sbjct: 452 SVHYPPQ-----LLGPSCSWEAEGLHCSCSSQAS 480
Score = 70.5 bits (171), Expect = 6e-12
Identities = 58/224 (25%), Positives = 93/224 (41%), Gaps = 40/224 (17%)
Query: 497 VALNVQYAPRDVRVRKIKPLS------------EIHSGNSVSLQCDFSSSHPKEVQFFWE 544
V L V YAP+D+ + + E+ G + L C S P + W
Sbjct: 243 VRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLS--WV 300
Query: 545 KNGRLLGKESQ-------LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLR 597
R+L L + D+G Y+C N +G + +A L V Y P LR
Sbjct: 301 LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLG-SQQQALDLSVQYPPENLR 359
Query: 598 VSMSPGDQ-------------VMEGKSATLTCESDANPPVSHYTWFDWNNQ---SLPYHS 641
V +S ++ V+EG+S L C + ++PP + +W W S P
Sbjct: 360 VMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPP-ARLSWTRWGQTVGPSQPSDP 418
Query: 642 QKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIG 685
L L P++++H G + C + +G LS L+V+Y P+ +G
Sbjct: 419 GVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS-LSVHYPPQLLG 461
Score = 42.7 bits (99), Expect = 0.001
Identities = 53/223 (23%), Positives = 91/223 (40%), Gaps = 32/223 (14%)
Query: 430 MPIREGDTVTLSCNYNSSNPSVTRYEWKPH-----GAWEEPSLGVLKIQNV-GWDNTTIA 483
+ +++G + L C +S P+ + + W +LG L+++ V D+
Sbjct: 275 LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLG-LELRGVRAGDSGRYT 333
Query: 484 CAACNSWCSWASPVALNVQYAPRDVRV---RKIKPLSE---------IHSGNSVSLQCDF 531
C A N S + L+VQY P ++RV + + + E + G S+ L C
Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393
Query: 532 SSSHPKEVQFFWEKNGRLLGKESQ-----LNFDSISPEDAGSYSCWVNNSIGQTASKAWT 586
SS P + W + G+ +G L I E G ++C + +G + + +
Sbjct: 394 HSSPPARLS--WTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLG-SQHVSLS 450
Query: 587 LEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTW 629
L V Y P+ L S S E + +C S A+P S W
Sbjct: 451 LSVHYPPQLLGPSCS-----WEAEGLHCSCSSQASPAPSLRWW 488
>gi|31377639 sialic acid binding Ig-like lectin 10 [Homo sapiens]
Length = 697
Score = 94.7 bits (234), Expect = 3e-19
Identities = 110/492 (22%), Positives = 191/492 (38%), Gaps = 70/492 (14%)
Query: 3 LLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNP 62
+L P LL +L D W+ E++ EG C+ +PC++ D +
Sbjct: 1 MLLPLLLSSLLGGSQAMDGRFWI-RVQESVMVPEGLCISVPCSFSYPRQDWTGSTPAYGY 59
Query: 63 EYNKNTSKFDGTRLYESTKDGKVP-SEQKRVQFLGDKNK-NCTLSIHPVHLNDSGQLGLR 120
+ T G + + + +V S + R Q GD K NC+L I + D Q R
Sbjct: 60 WFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFR 119
Query: 121 MES----KTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQW 176
+E + + L V+ P + +P ++ Q VT+ C+ N W
Sbjct: 120 VERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFN-----------W 168
Query: 177 LLEGVPMRQAAVTSTSLTIKSVFTR----SELKFSPQWSHHGKIVTCQLQDADGKFLSND 232
E P + T +L+ + S L F+P+ H +TC + + +
Sbjct: 169 AFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSAQR 228
Query: 233 TVQLNVKHTPK-LEIKVTPSDAIVRE--------------GDSVTMTCEVSSSNPEYTTV 277
TV+L V + P+ L I ++ + E G + + C S P T+
Sbjct: 229 TVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPP--ATL 286
Query: 278 SWLKDGTSLKKQNTF-----TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPE 332
SW+ L + + L L V SG+Y C+ N +G + + L VQY PE
Sbjct: 287 SWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLG-SQQRALDLSVQYPPE 345
Query: 333 PSTVQILHS--------------PAVEGSQVEFLCMSLANPLPTNYTWYHNGKEM---QG 375
V + + P +EG + +C++ ++P P +W G+ + Q
Sbjct: 346 NLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSP-PARLSWTQRGQVLSPSQP 404
Query: 376 RTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREG 435
+ +P++ H G ++C A + LG+ + L V Y PK + P E
Sbjct: 405 SDPGVLELPRVQVEHEGEFTCHARHPLGS--QHVSLSLSVHYSPK-----LLGPSCSWEA 457
Query: 436 DTVTLSCNYNSS 447
+ + SC+ +S
Sbjct: 458 EGLHCSCSSQAS 469
Score = 77.4 bits (189), Expect = 5e-14
Identities = 96/368 (26%), Positives = 151/368 (41%), Gaps = 65/368 (17%)
Query: 258 GDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNT-------FTLNLREVTKDQSGKYCCQ 310
G VT+ C + + E S+ G +L Q T L+ +D + C
Sbjct: 157 GQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCH 216
Query: 311 VS-NDVGPGRSEEVFLQVQYAPEPSTVQIL--HSPAVE--------------GSQVEFLC 353
V + G V L+V YAP + I ++PA+E G + LC
Sbjct: 217 VDFSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLC 276
Query: 354 MSLANPLPTNYTWYHNGKEMQ-----GRTEEKVHIPKILPWHAGTYSCVAENILGTGQRG 408
+ + P P +W + + G + +P + +G Y+C AEN LG+ QR
Sbjct: 277 AADSQP-PATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQR- 334
Query: 409 PGAELDVQYPPKKV--------TTVIQN-----PMPIREGDTVTLSCNYNSSNPSVTRYE 455
+L VQYPP+ + TV++N +P+ EG ++ L C +SS P+ R
Sbjct: 335 -ALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPA--RLS 391
Query: 456 WKPHGAWEEPSL----GVLKIQNVGWDNT-TIACAACNSWCSWASPVALNVQYAPRDVRV 510
W G PS GVL++ V ++ C A + S ++L+V Y+P
Sbjct: 392 WTQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHVSLSLSVHYSP----- 446
Query: 511 RKIKPLSEIHSGNSVSLQCDFSS-SHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSY 569
K L S + L C SS + P +W L G SQ +F+ ++P AG
Sbjct: 447 ---KLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQDSFE-VTPSSAGP- 501
Query: 570 SCWVNNSI 577
W N+S+
Sbjct: 502 --WANSSL 507
Score = 70.1 bits (170), Expect = 8e-12
Identities = 61/226 (26%), Positives = 93/226 (41%), Gaps = 42/226 (18%)
Query: 497 VALNVQYAPRDVRVRKIK--------------PLSEIHSGNSVSLQCDFSSSHPKEVQFF 542
V L V YAPRD+ + + P E G + L C S P +
Sbjct: 230 VRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLS-- 287
Query: 543 WEKNGRLLGKESQ-------LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRR 595
W R+L L + D+G Y+C N +G + +A L V Y P
Sbjct: 288 WVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLG-SQQRALDLSVQYPPEN 346
Query: 596 LRVSMSPGDQ-------------VMEGKSATLTCESDANPPVSHYTWFDWN---NQSLPY 639
LRV +S ++ V+EG+S L C + ++PP + +W + S P
Sbjct: 347 LRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPP-ARLSWTQRGQVLSPSQPS 405
Query: 640 HSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIG 685
L L V+V+H G + C + +G LS L+V+YSP+ +G
Sbjct: 406 DPGVLELPRVQVEHEGEFTCHARHPLGSQHVSLS-LSVHYSPKLLG 450
>gi|7657570 sialic acid binding Ig-like lectin 7 isoform 1 [Homo
sapiens]
Length = 467
Score = 92.8 bits (229), Expect = 1e-18
Identities = 82/280 (29%), Positives = 129/280 (46%), Gaps = 37/280 (13%)
Query: 91 RVQFLGD-KNKNCTLSIHPVHLNDSGQLGLRMESKTEKW---MERIHLNVSERPFPPHIQ 146
R LGD + KNCTLSI ++D+G+ RME KW +++ +NV+ P+I
Sbjct: 94 RFHLLGDPQTKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNIL 153
Query: 147 LPPEIQESQEVTLTCLLNFSC-YGYPIQLQWLLEGV-PMRQAAVTSTSLTIKSVFTRSEL 204
+P ++ LTC + ++C G P + W+ V P+ + S+ LT+
Sbjct: 154 IPGTLESGCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTL--------- 204
Query: 205 KFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-LEIKV-----TPSDAI---- 254
PQ HHG +TCQ+ +N T+QLNV + P+ L + V T S A+
Sbjct: 205 --IPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSS 262
Query: 255 ---VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---KKQNTFTLNLREVTKDQSGKYC 308
V EG S+ + C V S+ P +SW +L + N L L +V G++
Sbjct: 263 SLSVLEGQSLRLVCAVDSNPP--ARLSWTWRSLTLYPSQPSNPLVLEL-QVHLGDEGEFT 319
Query: 309 CQVSNDVGPGR-SEEVFLQVQYAPEPSTVQILHSPAVEGS 347
C+ N +G S + LQ +Y + V + AV G+
Sbjct: 320 CRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGA 359
Score = 42.4 bits (98), Expect = 0.002
Identities = 47/162 (29%), Positives = 74/162 (45%), Gaps = 25/162 (15%)
Query: 578 GQTASKAWTLEVLYAPRRLRVSMSPGD-------------QVMEGKSATLTCESDANPPV 624
G T ++ L V Y P+ L V++ G+ V+EG+S L C D+NPP
Sbjct: 225 GVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPP- 283
Query: 625 SHYTWFDWNNQSLPYHSQ---KLRLE-PVKVQHSGAYWCQGTNSVGKGRSPLS-TLTVYY 679
+ +W W + +L Y SQ L LE V + G + C+ NS+G L+ +L Y
Sbjct: 284 ARLSW-TWRSLTL-YPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEY 341
Query: 680 S----PETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQS 717
+ P + AVG A++ L+ C + + R R +S
Sbjct: 342 TGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKS 383
Score = 35.8 bits (81), Expect = 0.17
Identities = 58/292 (19%), Positives = 111/292 (38%), Gaps = 29/292 (9%)
Query: 256 REGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---KKQNTFTLNLREVTKDQSGKYCCQVS 312
R G+ ++ V+++NP + +D L + TL++R+ +G+Y ++
Sbjct: 67 RAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGRYFFRME 126
Query: 313 NDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLA----NPLPTNYTWYH 368
+ L V IL +E + L S+ P +W
Sbjct: 127 KGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISWMG 186
Query: 369 NGKEMQGRTEEKVHIPKILPW--HAGTYSCVAENILGTG-QRGPGAELDVQYPPKKVTTV 425
+ + + ++P H GT + G G +L+V YPP+ +T
Sbjct: 187 TSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPPQNLTVT 246
Query: 426 I-------------QNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAW-EEPSLG-VL 470
+ + + + EG ++ L C +S+ P+ + W+ + +PS VL
Sbjct: 247 VFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSNPLVL 306
Query: 471 KIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSG 522
++Q D C A NS S V+LN+ + K++P+S + G
Sbjct: 307 ELQVHLGDEGEFTCRAQNSLGS--QHVSLNLSL--QQEYTGKMRPVSGVLLG 354
>gi|148762980 sialic acid binding Ig-like lectin 14 [Homo sapiens]
Length = 396
Score = 91.3 bits (225), Expect = 3e-18
Identities = 81/336 (24%), Positives = 141/336 (41%), Gaps = 37/336 (11%)
Query: 6 PWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYN 65
P LLL +L + + + + +++ EG CV +PC++ S + +
Sbjct: 3 PLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFR 62
Query: 66 KNTSKFDGTRLYESTKDGKV-PSEQKRVQFLGD-KNKNCTLSIHPVHLNDSGQLGLRMES 123
+ + + D +V P Q R + LGD + KNC+LSI + D+G R+E
Sbjct: 63 DGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVER 122
Query: 124 ----KTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCY-GYPIQLQWLL 178
K +++L V+ P I ++ + L+C L SC G P+ W
Sbjct: 123 GRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTG 182
Query: 179 EGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNV 238
+ T +S EL +P+ HG +TCQ++ + + TVQLNV
Sbjct: 183 NALSPLDPETTRSS----------ELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNV 232
Query: 239 KHTPK---------------LEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDG 283
+ P+ L I ++EG S+ + C V S+ P ++SW ++G
Sbjct: 233 SYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPP--ASLSWFREG 290
Query: 284 TSLKKQNTF---TLNLREVTKDQSGKYCCQVSNDVG 316
+L T TL L + + G++ C+V + +G
Sbjct: 291 KALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLG 326
Score = 41.2 bits (95), Expect = 0.004
Identities = 48/178 (26%), Positives = 67/178 (37%), Gaps = 29/178 (16%)
Query: 516 LSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG-------KESQLNFDSISPEDAGS 568
L + SG L C S + G L + S+L PED G+
Sbjct: 151 LEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTP-RPEDHGT 209
Query: 569 -YSCWVNNSIGQ-TASKAWTLEVLYAPRRLRVS-------------MSPGDQV--MEGKS 611
+C V Q T + L V YAP+ L +S +S G V EG+S
Sbjct: 210 NLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQS 269
Query: 612 ATLTCESDANPPVSHYTWFDWN---NQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVG 666
L C D+NPP S +WF N S S L L + + G + C+ + +G
Sbjct: 270 LFLACTVDSNPPAS-LSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLG 326
Score = 39.7 bits (91), Expect = 0.012
Identities = 63/318 (19%), Positives = 120/318 (37%), Gaps = 52/318 (16%)
Query: 135 NVSERP-FPPHIQLPPEIQESQEVTLTCLLNFSCYGY----PIQLQWLLEGVPMRQAAVT 189
++ E+P + +Q +QE V + C ++ + P+ + W +G A V
Sbjct: 14 SLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVV 73
Query: 190 STSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDA----DGKFLSNDTVQLNVKHT---P 242
+T+ + V ++ +F K + + DA G + +VK++
Sbjct: 74 ATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQN 133
Query: 243 KLEIKVTPSDAIVREGD-----------SVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNT 291
KL ++VT A++ + D ++C + S +++ G +L +
Sbjct: 134 KLNLEVT---ALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDP 190
Query: 292 FTLNLREVT-----KDQSGKYCCQVSNDVGPGRSEE-VFLQVQYAPEPSTVQI------- 338
T E+T +D CQV +E V L V YAP+ + I
Sbjct: 191 ETTRSSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQLNVSYAPQNLAISIFFRNGTG 250
Query: 339 ---------LHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEM---QGRTEEKVHIPKI 386
+ P EG + C +NP P + +W+ GK + Q + +P I
Sbjct: 251 TALRILSNGMSVPIQEGQSLFLACTVDSNP-PASLSWFREGKALNPSQTSMSGTLELPNI 309
Query: 387 LPWHAGTYSCVAENILGT 404
G ++C ++ LG+
Sbjct: 310 GAREGGEFTCRVQHPLGS 327
>gi|4758822 nephrin precursor [Homo sapiens]
Length = 1241
Score = 90.9 bits (224), Expect = 4e-18
Identities = 141/616 (22%), Positives = 235/616 (38%), Gaps = 121/616 (19%)
Query: 153 ESQEVTLTCLLNFSCYGYPIQLQWLL---EGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209
E++ VTL+C+ S + L+W L + +PM + + + S L F +
Sbjct: 353 ENKNVTLSCVSKSS--RPRVLLRWWLGWRQLLPMEETVMDGLH---GGHISMSNLTFLAR 407
Query: 210 WSHHGKIVTCQ-LQDADGKFLSNDTVQLNVKH-TPKLEIKVTPSDAIVREGDSVTMTCEV 267
+G +TC+ +A K ++ LNVK+ KL I+ P +R G V + C
Sbjct: 408 REDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLA 467
Query: 268 SSSNPEYTTVSWLKD------------------GTSLKKQNTFTLNLREVT--KDQSGKY 307
NPE ++ W KD G+ K +TF+ L VT D K+
Sbjct: 468 IGGNPE-PSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKF 526
Query: 308 CCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWY 367
C+ S L VQ+ P T+ S G + C+S+++ P N +W
Sbjct: 527 TCKAGQ-----LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWD 581
Query: 368 HNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENIL------GTGQ----RGPGAE----- 412
G+ ++G P+ P+ S A ++L GQ R AE
Sbjct: 582 KEGERLEGVAAP----PRRAPFKG---SAAARSVLLQVSSRDHGQRVTCRAHSAELRETV 634
Query: 413 -----LDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEP-- 465
L+V Y P+ + + + +G+ + L + S+NP+ + W G P
Sbjct: 635 SSFYRLNVLYRPEFLGEQVLVVTAVEQGEAL-LPVSV-SANPAPEAFNWTFRGYRLSPAG 692
Query: 466 -------SLGVLKIQNVGWDNTTIACAAC-NSWCSWASPVALNVQYAPRDVRVRKIKPLS 517
S G L + NV + + C NS + + + L+V YAP +R ++ +
Sbjct: 693 GPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAP---TIRALQDPT 749
Query: 518 EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGR-------------LLGKESQLNFDSISPE 564
E++ G SV + C ++ F WE+ G G +L
Sbjct: 750 EVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLA 809
Query: 565 DAGSYSCWVNNSIGQTASKAWTLEVLYAPR-----RLRVSMSPGDQVMEGKSATLTCESD 619
AG+Y C V+N + A + L V +AP+ L + GD SATL C +
Sbjct: 810 QAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDST---SSATLHCRAR 866
Query: 620 ANPPVSHYTWFDWNNQSLP-----------------YHSQKLRLEPVK-VQHSGAYWCQG 661
P + F W +P HS L + V Q + C
Sbjct: 867 GVPNIV----FTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTA 922
Query: 662 TNSVGKGRSPLSTLTV 677
TN++G ++ + +++
Sbjct: 923 TNALGSDQTNIQLVSI 938
Score = 88.2 bits (217), Expect = 3e-17
Identities = 145/627 (23%), Positives = 241/627 (38%), Gaps = 99/627 (15%)
Query: 134 LNVSERPFPPHIQLPP----EIQESQEVTLTCLLNFSCYGYPIQ-LQWLLEGVPMRQAAV 188
+NV P PP I+ P ++ Q + L C+ G P+ LQWL G P+ A
Sbjct: 234 VNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARG---GNPLATLQWLKNGQPVSTAWG 290
Query: 189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKV 248
T + + RS L + + HG ++C+ ++ + L V P I +
Sbjct: 291 TEHTQAV----ARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIIL 346
Query: 249 TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT-------LNLREVT- 300
A E +VT++C SS P WL L + T +++ +T
Sbjct: 347 --GSASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTF 404
Query: 301 ----KDQSGKYCCQVSNDVGPGRS--EEVFLQVQYAPE------PSTVQILHSPAVEGSQ 348
+D C+ ++ + + + L V+Y + P Q L + G++
Sbjct: 405 LARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRA----GTR 460
Query: 349 VEFLCMSLANPLPTNYTWYHNGKEMQG----RTEEKVHIPKI----------LPWHAGTY 394
V +C+++ + WY + + + + +VH+ + L G
Sbjct: 461 VRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPS 520
Query: 395 SCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRY 454
A+ GQ +L VQ+PP VT ++ N +R GD + L+C SSNP V
Sbjct: 521 DNQAKFTCKAGQLSASTQLAVQFPPTNVT-ILANASALRPGDALNLTCVSVSSNPPVN-L 578
Query: 455 EWKPHGAWEE---------PSLGVLKIQNVGWDNTT------IACAACNSWC--SWASPV 497
W G E P G ++V ++ + C A ++ + +S
Sbjct: 579 SWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFY 638
Query: 498 ALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLG------ 551
LNV Y P + ++ ++ + G + L S++P F W G L
Sbjct: 639 RLNVLYRPEFLG-EQVLVVTAVEQGEA--LLPVSVSANPAPEAFNWTFRGYRLSPAGGPR 695
Query: 552 ----KESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVM 607
L+ +++ D G Y NS G TA L+V YAP +R P +V
Sbjct: 696 HRILSSGALHLWNVTRADDGLYQLHCQNSEG-TAEARLRLDVHYAPT-IRALQDP-TEVN 752
Query: 608 EGKSATLTCESDANPPV-SHYTWF----DWNNQSLPYHSQ-------KLRLEPVKVQHSG 655
G S + C DANP + + W D +QSL + +LR+ K+ +G
Sbjct: 753 VGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAG 812
Query: 656 AYWCQGTNSVGKGRSPLSTLTVYYSPE 682
AY C N V L L V ++P+
Sbjct: 813 AYQCIVDNGVAPPARRLLRLVVRFAPQ 839
Score = 58.9 bits (141), Expect = 2e-08
Identities = 155/719 (21%), Positives = 268/719 (37%), Gaps = 115/719 (15%)
Query: 177 LLEGVPMRQAAVTSTSLTIKSVFT-RSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQ 235
LL G + + + + +FT + + +P+ S + +++ C+ + +
Sbjct: 174 LLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFT 233
Query: 236 LNVKHTPKLEIKVTPS--DAIVREGDSVTMTCEVSSSNPEYTTVSWLKDG---------- 283
+NV P + P + VR G S+ + C NP T+ WLK+G
Sbjct: 234 VNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNP-LATLQWLKNGQPVSTAWGTE 292
Query: 284 -TSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEE-VFLQVQYAPEPSTVQILHS 341
T ++ + +R +D + C+ N V G E + LQV + PS + IL S
Sbjct: 293 HTQAVARSVLVMTVRP--EDHGAQLSCEAHNSVSAGTQEHGITLQVTF--PPSAIIILGS 348
Query: 342 PA-VEGSQVEFLCMSLANPLPTNYTWYHNGKE---MQGRTEEKVHIPKI----LPWHAG- 392
+ E V C+S ++ W+ ++ M+ + +H I L + A
Sbjct: 349 ASQTENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARR 408
Query: 393 -----TYSCVAENILGTGQR-GPGAELDVQYPPKKVTTVIQNP---MPIREGDTVTLSCN 443
T +C A + T + L+V+YP +K+ I+ P +R G V L C
Sbjct: 409 EDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKLW--IEGPPEGQKLRAGTRVRLVCL 466
Query: 444 YNSSNPSVTRYEWKPHGAWEEPSLGV----LKIQNVGWDNTTI--------------ACA 485
NP + +K E L + + +V +T A
Sbjct: 467 AIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKF 526
Query: 486 ACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEK 545
C + AS L VQ+ P +V + + S + G++++L C SS+P V W+K
Sbjct: 527 TCKAGQLSAS-TQLAVQFPPTNVTI--LANASALRPGDALNLTCVSVSSNP-PVNLSWDK 582
Query: 546 NGRLL--------------GKESQLNFDSISPEDAGS-YSCWVNNS-IGQTASKAWTLEV 589
G L ++ +S D G +C +++ + +T S + L V
Sbjct: 583 EGERLEGVAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETVSSFYRLNV 642
Query: 590 LYAPRRLRVSMSPGDQVM-----EGKSATLTCESDANPPVSHYTW----FDWNNQSLPYH 640
LY P L G+QV+ E A L ANP + W + + P H
Sbjct: 643 LYRPEFL------GEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRH 696
Query: 641 ----SQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSP--ETIGRRVAVGLGS 694
S L L V G Y NS G + L L V+Y+P + V +G
Sbjct: 697 RILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARL-RLDVHYAPTIRALQDPTEVNVGG 755
Query: 695 CLAILILAICG--LKLQRRWKR------TQSQQGLQENSSGQSFFVRNKKVRRAPLSEGP 746
+ I+ L W+R QS +++ S G + +R + A L++
Sbjct: 756 SVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLR---IHHAKLAQA- 811
Query: 747 HSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVG 805
G Y ++++G++ R + + E D+ + + LH R G
Sbjct: 812 ---GAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARG 867
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 90.1 bits (222), Expect = 8e-18
Identities = 142/582 (24%), Positives = 230/582 (39%), Gaps = 98/582 (16%)
Query: 149 PEIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIK-SVFTRSELKF 206
P E ++V L C + G P ++W L G + T + + SV S L
Sbjct: 38 PLDSEEKKVKLNCEVK----GNPKPHIRWKLNGTDV------DTGMDFRYSVVEGSLLIN 87
Query: 207 SPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCE 266
+P + C ++ G +S + +L + + + T S VR G + + C
Sbjct: 88 NPNKTQDAGTYQCTATNSFGTIVSREA-KLQFAYLDNFKTR-TRSTVSVRRGQGMVLLCG 145
Query: 267 VSSSNPEYTTVSWL-------KDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDV---- 315
+ E + +W+ +D Q T L + +V K G Y C V+N V
Sbjct: 146 PPPHSGELS-YAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHK 204
Query: 316 --GPG-----RSEEVF------LQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPT 362
GP R++ V ++VQ+ P TV P +G+ V+ C +L NP+PT
Sbjct: 205 VLGPPTPLILRNDGVMGEYEPKIEVQF---PETV-----PTAKGATVKLECFALGNPVPT 256
Query: 363 NYTWYHNGKEMQGRTEEK-----VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQY 417
+GK + + + IP AG Y CVAEN G+ +L
Sbjct: 257 IIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAEN--SRGKNVARGQLTFYA 314
Query: 418 PPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQ-NVG 476
P + + N + + + V C N P T Y+W +G EP L +IQ G
Sbjct: 315 QPNWIQKI--NDIHVAMEENVFWECKANG-RPKPT-YKWLKNG---EPLLTRDRIQIEQG 367
Query: 477 WDNTTIA---------CAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSL 527
N TI C A N S L+V D +K ++ + G V +
Sbjct: 368 TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVI 427
Query: 528 QCDFSSSHPKEVQFFWEKNGRLL--------GKESQLNFDSISPEDAGSYSCWVNNSIGQ 579
+C +S PK V + W+K +L ++ L +++ DAGSY+C N G
Sbjct: 428 ECKPKAS-PKPV-YTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFG- 484
Query: 580 TASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPY 639
TAS L V+ P R+ V S D V G+S L C+ + + + +N + +
Sbjct: 485 TASSTGNL-VVKDPTRVMVPPSSMD-VTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDF 542
Query: 640 -----HSQK---------LRLEPVKVQHSGAYWCQGTNSVGK 667
H ++ L + ++++H+G Y C SV +
Sbjct: 543 DRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDR 584
Score = 79.7 bits (195), Expect = 1e-14
Identities = 109/459 (23%), Positives = 170/459 (37%), Gaps = 57/459 (12%)
Query: 257 EGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK---------QNTFTLNLREVTKDQSGKY 307
E V + CEV NP+ + W +GT + + + +N T+D +G Y
Sbjct: 42 EEKKVKLNCEVKG-NPK-PHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQD-AGTY 98
Query: 308 CCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTW- 366
C +N G S E LQ Y T G + LC + +Y W
Sbjct: 99 QCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWI 158
Query: 367 ------YHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQ-RGPGAELDV---- 415
Y + + + ++I K+ G Y+CV N + + GP L +
Sbjct: 159 FNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDG 218
Query: 416 ---QYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVT----RYEWKP--HGAWEEPS 466
+Y PK + +P +G TV L C + NP T R + KP A S
Sbjct: 219 VMGEYEPK-IEVQFPETVPTAKGATVKLEC-FALGNPVPTIIWRRADGKPIARKARRHKS 276
Query: 467 LGVLKIQNVGWDNTTI-ACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSV 525
G+L+I N ++ + C A NS + L P I+ +++IH
Sbjct: 277 NGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPN-----WIQKINDIHVAMEE 331
Query: 526 SLQCDFSSSHPKEVQFFWEKNG-------RLLGKESQLNFDSISPEDAGSYSCWVNNSIG 578
++ + ++ + + W KNG R+ ++ LN ++ DAG Y C N G
Sbjct: 332 NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 391
Query: 579 QTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYTW------FD 631
S A + P R + V G + C+ A+P PV YTW
Sbjct: 392 VIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV--YTWKKGRDILK 449
Query: 632 WNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRS 670
N + LR+ V +G+Y C TN G S
Sbjct: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASS 488
Score = 67.0 bits (162), Expect = 7e-11
Identities = 96/392 (24%), Positives = 162/392 (41%), Gaps = 52/392 (13%)
Query: 229 LSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKK 288
L ND V ++ PK+E++ P +G +V + C + NP T + DG + +
Sbjct: 214 LRNDGVM--GEYEPKIEVQF-PETVPTAKGATVKLEC-FALGNPVPTIIWRRADGKPIAR 269
Query: 289 Q-----NTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPA 343
+ + L + ++ +G Y C N G + Q+ + +P+ +Q ++
Sbjct: 270 KARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARG---QLTFYAQPNWIQKINDIH 326
Query: 344 VEGSQVEFL-CMSLANPLPTNYTWYHNGKEMQGRTEEKV-----HIPKILPWHAGTYSCV 397
V + F C + P PT Y W NG+ + R ++ +I + AG Y C+
Sbjct: 327 VAMEENVFWECKANGRPKPT-YKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCL 385
Query: 398 AENILGTGQRGPGAELDV-QYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEW 456
AEN G AEL V P T+++ ++ G V + C +S V Y W
Sbjct: 386 AENKHGV--IFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV--YTW 441
Query: 457 KP-HGAWEEPSL------GVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDV 508
K +E G L+I NV D + C A N + + +S L V+ R +
Sbjct: 442 KKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVM 501
Query: 509 RVRKIKPLS-EIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLL-------------GKES 554
+ P S ++ G S+ L C + H ++ F W NG L+ G++S
Sbjct: 502 ----VPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDS 557
Query: 555 --QLNFDSISPEDAGSYSCWVNNSIGQTASKA 584
L +I + AG Y C V S+ + ++ A
Sbjct: 558 AGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAA 589
Score = 33.9 bits (76), Expect = 0.65
Identities = 37/186 (19%), Positives = 66/186 (35%), Gaps = 26/186 (13%)
Query: 246 IKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWL---------KDGTSLKK----QNTF 292
+ V PS V G+S+ + C+V+ + +W +DG ++ +
Sbjct: 500 VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAG 559
Query: 293 TLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEP-----------STVQILHS 341
L +R + +GKY C V V S L V+ P P +T Q+
Sbjct: 560 DLMIRNIQLKHAGKYVCMVQTSVDR-LSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWR 618
Query: 342 PAVEG-SQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAEN 400
P + S + + P + E+ + + PW + VA N
Sbjct: 619 PGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAAN 678
Query: 401 ILGTGQ 406
++G G+
Sbjct: 679 VIGIGE 684
>gi|23943856 sialic acid binding Ig-like lectin 9 [Homo sapiens]
Length = 463
Score = 89.7 bits (221), Expect = 1e-17
Identities = 85/318 (26%), Positives = 137/318 (43%), Gaps = 41/318 (12%)
Query: 36 EGACVWIPCTYR-ALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQK-RVQ 93
EG CV +PC++ G + + H + + + + + V E + R
Sbjct: 33 EGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFH 92
Query: 94 FLGDKN-KNCTLSIHPVHLNDSGQLGLRMESKTEKWM---ERIHLNVSERPFPPHIQLPP 149
LGD + KNCTLSI +D+G+ RME + KW R+ +NV+ P+I +P
Sbjct: 93 LLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPG 152
Query: 150 EIQESQEVTLTCLLNFSC-YGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSP 208
++ LTC + ++C G P + W+ V + T +S+ L P
Sbjct: 153 TLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSV----------LTLIP 202
Query: 209 QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-LEIKVTPSDAIVR----------- 256
Q HG +TCQ+ +N TV LNV + P+ L + V D V
Sbjct: 203 QPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSL 262
Query: 257 -EGDSVTMTC---EVSSSNPEYTTVSWLKDGTSL---KKQNTFTLNLREVTKDQSGKYCC 309
EG S+ + C V S+ P ++SW G +L + N L L V + ++ C
Sbjct: 263 PEGQSLRLVCAVDAVDSNPPARLSLSW--RGLTLCPSQPSNPGVLELPWVHLRDAAEFTC 320
Query: 310 QVSNDVGPGRSEEVFLQV 327
+ N +G S++V+L V
Sbjct: 321 RAQNPLG---SQQVYLNV 335
Score = 35.8 bits (81), Expect = 0.17
Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 25/164 (15%)
Query: 563 PEDAG-SYSCWVN-NSIGQTASKAWTLEVLYAPRRLRVSMSPGD-------------QVM 607
P+D G S +C V T +K L V Y P+ L +++ GD +
Sbjct: 204 PQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLP 263
Query: 608 EGKSATLTCESDA---NPPVSHYTWFDWNNQSL----PYHSQKLRLEPVKVQHSGAYWCQ 660
EG+S L C DA NPP W +L P + L L V ++ + + C+
Sbjct: 264 EGQSLRLVCAVDAVDSNPPAR--LSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCR 321
Query: 661 GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAIC 704
N +G + L+ + + + V G G+ A++ L+ C
Sbjct: 322 AQNPLGSQQVYLNVSLQSKATSGVTQGVVGGAGA-TALVFLSFC 364
>gi|205830473 sialic acid binding Ig-like lectin 11 isoform 2 [Homo
sapiens]
Length = 602
Score = 89.0 bits (219), Expect = 2e-17
Identities = 95/411 (23%), Positives = 158/411 (38%), Gaps = 54/411 (13%)
Query: 36 EGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVP-SEQKRVQF 94
EG CV + C + + + TS G + + + +V S + R Q
Sbjct: 46 EGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDRFQL 105
Query: 95 LGDKNK-NCTLSIHPVHLNDSGQLGLRMESKTEK----WMERIHLNVSERPFPPHIQLPP 149
GD K +C+L I D R+E + L V+ P + +P
Sbjct: 106 TGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYIPE 165
Query: 150 EIQESQEVTLTCLLNFSCYGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSP 208
++ Q VT+ C+ N++ P W A S T S S L F+P
Sbjct: 166 TLEPGQPVTVICVFNWAFKKCPAPSFSWT--------GAALSPRRTRPSTSHFSVLSFTP 217
Query: 209 QWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-------------LEIKVTPSDAIV 255
H +TC + + + TV+L V + PK LE++ V
Sbjct: 218 SPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEV 277
Query: 256 REGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQN-----TFTLNLREVTKDQSGKYCCQ 310
++G + + C S P T+SW+ L + T L LR V SG+Y C+
Sbjct: 278 QKGQFLRLLCAADSQPP--ATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCR 335
Query: 311 VSNDVGPGRSEEVFLQVQYAPEPSTVQILHS--------------PAVEGSQVEFLCMSL 356
N +G + + + L VQY PE V + + P +EG + +C++
Sbjct: 336 AENRLG-SQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTH 394
Query: 357 ANPLPTNYTWYHNGKEM---QGRTEEKVHIPKILPWHAGTYSCVAENILGT 404
++P P +W G+ + Q + +P I H G ++C A++ LG+
Sbjct: 395 SSP-PARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGS 444
Score = 71.6 bits (174), Expect = 3e-12
Identities = 78/332 (23%), Positives = 130/332 (39%), Gaps = 56/332 (16%)
Query: 497 VALNVQYAPRDVRVRKIKPLS------------EIHSGNSVSLQCDFSSSHPKEVQFFWE 544
V L V YAP+D+ + + E+ G + L C S P + W
Sbjct: 243 VRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLS--WV 300
Query: 545 KNGRLLGKESQ-------LNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLR 597
R+L L + D+G Y+C N +G + +A L V Y P LR
Sbjct: 301 LQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLG-SQQQALDLSVQYPPENLR 359
Query: 598 VSMSPGDQ-------------VMEGKSATLTCESDANPPVSHYTWFDWNNQ---SLPYHS 641
V +S ++ V+EG+S L C + ++PP + +W W S P
Sbjct: 360 VMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPP-ARLSWTRWGQTVGPSQPSDP 418
Query: 642 QKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPE---TIGRRVAVGLG----- 693
L L P++++H G + C + +G LS L+V++ E +G A+G G
Sbjct: 419 GVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS-LSVHWKLEHGGGLGLGAALGAGVAALL 477
Query: 694 ---SCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLG 750
SCL + + IC + + KR ++Q + S +++ + P
Sbjct: 478 AFCSCLVVFRVKICRKEAR---KRAAAEQDVPSTLGPISQGHQHECSAGSSQDHPPPGAA 534
Query: 751 CYNPMM--EDGISYTTLRFPEMNIPRTGDAES 780
Y P E + Y +L F + + D E+
Sbjct: 535 TYTPGKGEEQELHYASLSFQGLRLWEPADQEA 566
Score = 52.4 bits (124), Expect = 2e-06
Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 48/279 (17%)
Query: 228 FLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK 287
FLSN T K ++ + + + G VT+ C + + + S+ G +L
Sbjct: 143 FLSNAFFLKVTALTKKPDVYIPET---LEPGQPVTVICVFNWAFKKCPAPSFSWTGAALS 199
Query: 288 KQNT-------FTLNLREVTKDQSGKYCCQVS-NDVGPGRSEEVFLQVQYAPEPSTVQIL 339
+ T L+ +D C V + G V L+V YAP+ + I
Sbjct: 200 PRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISIS 259
Query: 340 H--SPAVE------------GSQVEFLCMSLANPLPTNYTWYHNGKEMQ-----GRTEEK 380
H + A+E G + LC + + P P +W + + G
Sbjct: 260 HDNTSALELQGNVIYLEVQKGQFLRLLCAADSQP-PATLSWVLQDRVLSSSHPWGPRTLG 318
Query: 381 VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKV--------TTVIQN---- 428
+ + + +G Y+C AEN LG+ Q+ +L VQYPP+ + TV++N
Sbjct: 319 LELRGVRAGDSGRYTCRAENRLGSQQQ--ALDLSVQYPPENLRVMVSQANRTVLENLGNG 376
Query: 429 -PMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPS 466
+P+ EG ++ L C +SS P+ R W G PS
Sbjct: 377 TSLPVLEGQSLRLVCVTHSSPPA--RLSWTRWGQTVGPS 413
Score = 34.3 bits (77), Expect = 0.50
Identities = 43/187 (22%), Positives = 75/187 (40%), Gaps = 31/187 (16%)
Query: 430 MPIREGDTVTLSCNYNSSNPSVTRYEWKPH-----GAWEEPSLGVLKIQNV-GWDNTTIA 483
+ +++G + L C +S P+ + + W +LG L+++ V D+
Sbjct: 275 LEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLG-LELRGVRAGDSGRYT 333
Query: 484 CAACNSWCSWASPVALNVQYAPRDVRV---RKIKPLSE---------IHSGNSVSLQCDF 531
C A N S + L+VQY P ++RV + + + E + G S+ L C
Sbjct: 334 CRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVT 393
Query: 532 SSSHPKEVQFFWEKNGRLLGKESQ-----LNFDSISPEDAGSYSCWVNNSIGQ-----TA 581
SS P + W + G+ +G L I E G ++C + +G +
Sbjct: 394 HSSPPARLS--WTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSL 451
Query: 582 SKAWTLE 588
S W LE
Sbjct: 452 SVHWKLE 458
>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
Length = 1264
Score = 87.4 bits (215), Expect = 5e-17
Identities = 107/410 (26%), Positives = 153/410 (37%), Gaps = 93/410 (22%)
Query: 308 CCQVSNDVGPGRSEEVFLQVQYAPEP-STVQILHSPAVEGSQVEFLCMSLANPLPTNYTW 366
C VS+D+ P + EP S VQ L P V A P+ T +W
Sbjct: 20 CSSVSSDLAP----------YFTSEPLSAVQKLGGPVVLHCS--------AQPVTTRISW 61
Query: 367 YHNGKEMQGRTEE-KVH-----IPKILPWHAGTYSCVAENILGTGQRGPGAEL-----DV 415
HNGK + G E K+H I + G Y C+A N +G GP D
Sbjct: 62 LHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGDF 121
Query: 416 QYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSL-------- 467
K V T E + C SNP +K G W E S
Sbjct: 122 GSSTKHVITA-------EEKSAGFIGCRVPESNPKA-EVRYKIRGKWLEHSTENYLILPS 173
Query: 468 GVLKIQNVGW-DNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSE-------- 518
G L+I NV D + CAA N PV ++ P ++ +P S+
Sbjct: 174 GNLQILNVSLEDKGSYKCAAYN-------PVTHQLKVEPIGRKLLVSRPSSDDVHILHPT 226
Query: 519 ------IHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQ-------LNFDSISPED 565
+ S + V+L+C S +V +W K+G+ + S L DS+ P D
Sbjct: 227 HSQALAVLSRSPVTLECVVSGVPAPQV--YWLKDGQDIAPGSNWRRLYSHLATDSVDPAD 284
Query: 566 AGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVME-GKSATLTCESDANPPV 624
+G+YSC N G + + VL +S DQ++ G + TC+ N P
Sbjct: 285 SGNYSCMAGNKSGDVKYVTYMVNVL---EHASISKGLQDQIVSLGATVHFTCDVHGN-PA 340
Query: 625 SHYTWFDWNNQSLPYH--------SQKLRLEPVKVQHSGAYWCQGTNSVG 666
+ TWF + + P H L++ V V+ G Y C N +G
Sbjct: 341 PNCTWF---HNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIG 387
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/211 (27%), Positives = 80/211 (37%), Gaps = 17/211 (8%)
Query: 261 VTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQ-----SGKYCCQVSNDV 315
VT+ C VS V WLKDG + + + + D SG Y C N
Sbjct: 239 VTLECVVSGVPAPQ--VYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAGNKS 296
Query: 316 GPGRSEEVFLQVQYAPEPSTVQILHSPAVE-GSQVEFLCMSLANPLPTNYTWYHNGKEMQ 374
G + V V S + L V G+ V F C NP P N TW+HN + +
Sbjct: 297 GDVKY--VTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAP-NCTWFHNAQPIH 353
Query: 375 GRTEEK-----VHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNP 429
+ I + G Y CVA+N +G E++ K V
Sbjct: 354 PSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVS 413
Query: 430 MPIREGDTVTLSCNYNSSNPSVTRYEWKPHG 460
+ +GD VTLSCN + V R+ + HG
Sbjct: 414 AKVADGDFVTLSCNASGLPVPVIRW-YDSHG 443
Score = 34.7 bits (78), Expect = 0.38
Identities = 43/210 (20%), Positives = 83/210 (39%), Gaps = 41/210 (19%)
Query: 153 ESQEVTLTCLLNFSC--YGYPI-QLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQ 209
+ Q V+L ++F+C +G P W P+ +A + + + LK S
Sbjct: 319 QDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSA--------RHLTAGNGLKISGV 370
Query: 210 WSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVS- 268
+ C + G S +++ K I P A V +GD VT++C S
Sbjct: 371 TVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASG 430
Query: 269 ---------------SSNPEYTTVSWLK-------DGTSLK-------KQNTFTLNLREV 299
+S+P S + +G +L+ + +L+++ V
Sbjct: 431 LPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAV 490
Query: 300 TKDQSGKYCCQVSNDVGPGRSEEVFLQVQY 329
T++ +GKY C+ +N+ G ++E + V +
Sbjct: 491 TQEHAGKYICEAANEHGTTQAEASLMVVPF 520
>gi|157694526 Fc receptor-like 5 [Homo sapiens]
Length = 977
Score = 86.3 bits (212), Expect = 1e-16
Identities = 122/504 (24%), Positives = 201/504 (39%), Gaps = 43/504 (8%)
Query: 233 TVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTF 292
+V + V H P L + +P D I EG VT+ CE + + +G +L++++
Sbjct: 372 SVTVPVSH-PVLNLS-SPEDLIF-EGAKVTLHCEAQRGSLPIL-YQFHHEGAALERRSAN 427
Query: 293 TLN----LREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV--EG 346
+ +T + SG Y C N GP RS+ V L V + + + A+ EG
Sbjct: 428 SAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEG 487
Query: 347 SQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKV----HIPKILPWHAGTYSCVAENIL 402
+ V C Y +YH + + V + H+G Y C A+N
Sbjct: 488 ATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGF 547
Query: 403 GTGQRGPGAELDVQYPPKKVTTVIQNP-MPIREGDTVTLSCNYNSSNPSVTRYEWKPH-- 459
G QR L V P + ++ P GD + L C +P + W H
Sbjct: 548 GP-QRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPI--LYWFYHED 604
Query: 460 ---GAWEEPSLG--VLKIQNVGWDNTTIACAACNSWCSWAS-PVALNVQYAPRDVRVRKI 513
G+ PS G + + +C A N + S ++L+V +
Sbjct: 605 VTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFR 664
Query: 514 KPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRL------LGKESQLNFDSISPEDAG 567
P ++ G+ + L C+ + +F+ ++ L G + N S++ E +G
Sbjct: 665 APRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNL-SLTTEHSG 723
Query: 568 SYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM-SPGDQVMEGKSATLTCESDANPPVSH 626
YSC +N + S+ TL+V R +++ +PG G L CE+ P+
Sbjct: 724 IYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLIL 783
Query: 627 YTWF----DWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPE 682
Y +F N+S P L L + +HSG Y C+ N +G RS T+T+Y +
Sbjct: 784 YRFFHEDVTLGNRSSPSGGASLNLS-LTAEHSGNYSCEADNGLGAQRS--ETVTLYITGL 840
Query: 683 TIGRRVAVGLGSCLAILILAICGL 706
T R G +A +L+I GL
Sbjct: 841 TANRSGPFATG--VAGGLLSIAGL 862
Score = 65.9 bits (159), Expect = 2e-10
Identities = 114/474 (24%), Positives = 184/474 (38%), Gaps = 64/474 (13%)
Query: 241 TPKLEIKVTPSDAIVREGDSVTMTCE-VSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREV 299
TP+ I + P V +G+ VT+TC+ +P+ T G + ++ N+ EV
Sbjct: 20 TPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPD--NILEV 77
Query: 300 TKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSP--AVEGSQVEFLCMSLA 357
+SG+Y CQ G S V L S IL +P EG V C + A
Sbjct: 78 --QESGEYRCQAQ---GSPLSSPVHLDFS-----SASLILQAPLSVFEGDSVVLRCRAKA 127
Query: 358 NPLPTNYTWYHNGKEM---QGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELD 414
+ N T Y N + RT+ HIP G Y C ++
Sbjct: 128 E-VTLNNTIYKNDNVLAFLNKRTD--FHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQ 184
Query: 415 VQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSS---NPSVTRYEWKPHGAWEEPSLGVLK 471
VQ P + + PI G+ VTL+C S + R+ + ++ +LG+
Sbjct: 185 VQEPFTRPVLRASSFQPI-SGNPVTLTCETQLSLERSDVPLRFRFFR----DDQTLGL-- 237
Query: 472 IQNVGWD---NTTIACAACNS----WCSWASPVALNVQYAPRD---VRVRKIKPLSEIH- 520
GW N I WC A+ + +PR V++ P+ +
Sbjct: 238 ----GWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSP 293
Query: 521 ------SGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKE------SQLNFDSISPEDAGS 568
G V+L C+ + + F+ + L K + ++F S++ E++G+
Sbjct: 294 EKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISF-SLTTENSGN 352
Query: 569 YSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM-SPGDQVMEGKSATLTCESD-ANPPV-- 624
Y C +N +G SKA +L V +++ SP D + EG TL CE+ + P+
Sbjct: 353 YYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILY 412
Query: 625 -SHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTV 677
H+ +S + +HSG Y+C N G RS +L+V
Sbjct: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSV 466
Score = 62.8 bits (151), Expect = 1e-09
Identities = 87/392 (22%), Positives = 147/392 (37%), Gaps = 76/392 (19%)
Query: 328 QYAPEPSTVQILHSP---AVEGSQVEFLCMSLANPLPTNYTWYHN--GKEMQGRTEEKVH 382
Q+A P + L P +G +V C P WYH GKE+ T + +
Sbjct: 16 QFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNI- 74
Query: 383 IPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSC 442
+ +G Y C A+ G V + ++Q P+ + EGD+V L C
Sbjct: 75 ---LEVQESGEYRCQAQ--------GSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRC 123
Query: 443 ---------NYNSSNPSVTRYEWK------PHGAWEEPSLGVLKIQNVGWDNTTIACAAC 487
N N +V + K PH + DN C
Sbjct: 124 RAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLK--------------DNGAYRCTGY 169
Query: 488 NSWCSWASPVALNVQ----YAPRDVRVRKIKPLSEIHSGNSVSLQCDFS-----SSHPKE 538
C S + +Q + +R +P+ SGN V+L C+ S P
Sbjct: 170 KESCCPVSSNTVKIQVQEPFTRPVLRASSFQPI----SGNPVTLTCETQLSLERSDVPLR 225
Query: 539 VQFFWEKNGRLLGKESQLNFD--SISPEDAGSYSC---WVNNSIGQTASKAWTLEVLYAP 593
+FF + LG NF ++ +D+G Y C + S+ + ++W ++V
Sbjct: 226 FRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSW-IQVQIPA 284
Query: 594 RRLRVSMSPGDQV-MEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLE----- 647
+++SP + EG TL CE+ + S T + + ++ +P + +R E
Sbjct: 285 SHPVLTLSPEKALNFEGTKVTLHCETQED---SLRTLYRFYHEGVPLRHKSVRCERGASI 341
Query: 648 --PVKVQHSGAYWCQGTNSVGKGRSPLSTLTV 677
+ ++SG Y+C N +G S +L+V
Sbjct: 342 SFSLTTENSGNYYCTADNGLGAKPSKAVSLSV 373
Score = 62.4 bits (150), Expect = 2e-09
Identities = 106/480 (22%), Positives = 191/480 (39%), Gaps = 34/480 (7%)
Query: 229 LSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTT---VSWLKDGTS 285
+S++TV++ V+ P + S G+ VT+TCE S + +D +
Sbjct: 176 VSSNTVKIQVQE-PFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQT 234
Query: 286 LKKQNTFTLNLR--EVTKDQSGKYCCQVSNDVGP--GRSEEVFLQVQYAPEPSTVQILHS 341
L + + N + + SG Y C+ + S ++QVQ + +
Sbjct: 235 LGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPE 294
Query: 342 PAV--EGSQVEFLCMSLANPLPTNYTWYHNG---KEMQGRTEEKVHIP-KILPWHAGTYS 395
A+ EG++V C + + L T Y +YH G + R E I + ++G Y
Sbjct: 295 KALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYY 354
Query: 396 CVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMP-IREGDTVTLSCNYNSSNPSVTRY 454
C A+N LG + L V P + +P I EG VTL C + + Y
Sbjct: 355 CTADNGLG-AKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPIL-Y 412
Query: 455 EWKPHGAWEE----PSLG--VLKIQNVGWDNTTIACAACNSWCSWAS-PVALNVQYAPRD 507
++ GA E S G + + C A N + S V+L+V
Sbjct: 413 QFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSH 472
Query: 508 VRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKES----QLNFD-SIS 562
+ + G +V+L C+ P+ + F+ ++ L + +++F S++
Sbjct: 473 PVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLT 532
Query: 563 PEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMS-PGDQVMEGKSATLTCESD-A 620
+G+Y C +N G S+ +L V R +++ P Q + G L CE+
Sbjct: 533 EGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRG 592
Query: 621 NPPVSHYTWFD---WNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTV 677
+PP+ ++ + + + S P + + +HSG Y C+ N + S +L+V
Sbjct: 593 SPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSV 652
>gi|16506826 sialic acid binding immunoglobulin-like lectin-like
protein 1 isoform b precursor [Homo sapiens]
Length = 477
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/317 (23%), Positives = 130/317 (41%), Gaps = 34/317 (10%)
Query: 22 SKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTK 81
S++ E PE++ EG CV +PC+ + + + + + + +T
Sbjct: 31 SRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTP 90
Query: 82 DGKVPSEQK-RVQFLGD-KNKNCTLSIHPVHLNDSGQLGLRMESKTEKW---MERIHLNV 136
GKV + R LGD + NC+LSI DSG+ ++E + KW +++ ++V
Sbjct: 91 SGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHV 150
Query: 137 SERPFPPHIQLPPEIQESQEVTLTCLLNFSC-YGYPIQLQWLLEGVPMRQAAVTSTSLTI 195
+ P +P ++ LTC + ++C G P + W+ V +T +S+
Sbjct: 151 TALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSM-- 208
Query: 196 KSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-LEIKVTPSDAI 254
L PQ HG +TCQ+ V+LN+ + P+ L + V D
Sbjct: 209 --------LSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGT 260
Query: 255 ------------VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---KKQNTFTLNLREV 299
V EG S+ + C V S+ P +SW +L + N L L V
Sbjct: 261 ASTTLRNGSALSVLEGQSLHLVCAVDSNPP--ARLSWTWGSLTLSPSQSSNLGVLELPRV 318
Query: 300 TKDQSGKYCCQVSNDVG 316
G++ C+ N +G
Sbjct: 319 HVKDEGEFTCRAQNPLG 335
Score = 47.4 bits (111), Expect = 6e-05
Identities = 40/130 (30%), Positives = 60/130 (46%), Gaps = 21/130 (16%)
Query: 563 PEDAG-SYSCWVN-NSIGQTASKAWTLEVLYAPRRLRVSMSPGD-------------QVM 607
P+D G S +C V G T ++A L + Y P+ L +++ GD V+
Sbjct: 215 PQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVL 274
Query: 608 EGKSATLTCESDANPPVSHYTWFDWNNQSL-PYHSQK---LRLEPVKVQHSGAYWCQGTN 663
EG+S L C D+NPP + +W W + +L P S L L V V+ G + C+ N
Sbjct: 275 EGQSLHLVCAVDSNPP-ARLSW-TWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQN 332
Query: 664 SVGKGRSPLS 673
+G LS
Sbjct: 333 PLGSQHISLS 342
Score = 34.7 bits (78), Expect = 0.38
Identities = 45/206 (21%), Positives = 77/206 (37%), Gaps = 33/206 (16%)
Query: 240 HTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYT--TVSWLKDGTSLKKQN-TFT--- 293
H P I T + G +TC V + + T T++W+ G S+ + T T
Sbjct: 155 HMPTFSIPGT-----LESGHPRNLTCSVPWACEQGTPPTITWM--GASVSSLDPTITRSS 207
Query: 294 -LNLREVTKDQSGKYCCQVS-NDVGPGRSEEVFLQVQYAPEPSTVQILHSPA-------- 343
L+L +D CQV+ G + V L + Y P+ T+ +
Sbjct: 208 MLSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRN 267
Query: 344 ------VEGSQVEFLCMSLANPLPTNYTWYHNGKEM---QGRTEEKVHIPKILPWHAGTY 394
+EG + +C +NP P +W + Q + +P++ G +
Sbjct: 268 GSALSVLEGQSLHLVCAVDSNP-PARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEF 326
Query: 395 SCVAENILGTGQRGPGAELDVQYPPK 420
+C A+N LG+ L +Y K
Sbjct: 327 TCRAQNPLGSQHISLSLSLQNEYTGK 352
>gi|16506828 sialic acid binding immunoglobulin-like lectin-like
protein 1 isoform a precursor [Homo sapiens]
Length = 595
Score = 85.5 bits (210), Expect = 2e-16
Identities = 76/317 (23%), Positives = 130/317 (41%), Gaps = 34/317 (10%)
Query: 22 SKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTK 81
S++ E PE++ EG CV +PC+ + + + + + + +T
Sbjct: 149 SRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTP 208
Query: 82 DGKVPSEQK-RVQFLGD-KNKNCTLSIHPVHLNDSGQLGLRMESKTEKW---MERIHLNV 136
GKV + R LGD + NC+LSI DSG+ ++E + KW +++ ++V
Sbjct: 209 SGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHV 268
Query: 137 SERPFPPHIQLPPEIQESQEVTLTCLLNFSC-YGYPIQLQWLLEGVPMRQAAVTSTSLTI 195
+ P +P ++ LTC + ++C G P + W+ V +T +S+
Sbjct: 269 TALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSM-- 326
Query: 196 KSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPK-LEIKVTPSDAI 254
L PQ HG +TCQ+ V+LN+ + P+ L + V D
Sbjct: 327 --------LSLIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGT 378
Query: 255 ------------VREGDSVTMTCEVSSSNPEYTTVSWLKDGTSL---KKQNTFTLNLREV 299
V EG S+ + C V S+ P +SW +L + N L L V
Sbjct: 379 ASTTLRNGSALSVLEGQSLHLVCAVDSNPP--ARLSWTWGSLTLSPSQSSNLGVLELPRV 436
Query: 300 TKDQSGKYCCQVSNDVG 316
G++ C+ N +G
Sbjct: 437 HVKDEGEFTCRAQNPLG 453
Score = 50.4 bits (119), Expect = 7e-06
Identities = 84/383 (21%), Positives = 150/383 (39%), Gaps = 57/383 (14%)
Query: 91 RVQFLGD-KNKNCTLSIHPVHLNDSGQLGLRMESKTEKW---MERIHLNVSERP-----F 141
R LGD +NK+CTLSI +D+G +E KW +++ +NV+ +
Sbjct: 92 RFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRY 151
Query: 142 PPHIQLPPEIQESQEVTLTCLLNFSCYGY----PIQLQWLLEG--VPMRQAAVTST--SL 193
+ +QE V++ C + + Y + P+ W EG +P T+T
Sbjct: 152 RLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGK 211
Query: 194 TIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKF---LSNDTVQLNVKHTPKLEIKVT- 249
+ R L PQ ++ + + GK+ + + + N + KL + VT
Sbjct: 212 VQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIY-DKLSVHVTA 270
Query: 250 ----PSDAI---VREGDSVTMTCEVSSSNPEYT--TVSWLKDGTSLKKQN-TFT----LN 295
P+ +I + G +TC V + + T T++W+ G S+ + T T L+
Sbjct: 271 LTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWM--GASVSSLDPTITRSSMLS 328
Query: 296 LREVTKDQSGKYCCQVS-NDVGPGRSEEVFLQVQYAPEPSTVQILHS------------- 341
L +D CQV+ G + V L + Y P+ T+ +
Sbjct: 329 LIPQPQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSA 388
Query: 342 -PAVEGSQVEFLCMSLANPLPTNYTWYHNGKEM---QGRTEEKVHIPKILPWHAGTYSCV 397
+EG + +C +NP P +W + Q + +P++ G ++C
Sbjct: 389 LSVLEGQSLHLVCAVDSNP-PARLSWTWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCR 447
Query: 398 AENILGTGQRGPGAELDVQYPPK 420
A+N LG+ L +Y K
Sbjct: 448 AQNPLGSQHISLSLSLQNEYTGK 470
Score = 47.4 bits (111), Expect = 6e-05
Identities = 40/130 (30%), Positives = 60/130 (46%), Gaps = 21/130 (16%)
Query: 563 PEDAG-SYSCWVN-NSIGQTASKAWTLEVLYAPRRLRVSMSPGD-------------QVM 607
P+D G S +C V G T ++A L + Y P+ L +++ GD V+
Sbjct: 333 PQDHGTSLTCQVTLPGAGVTMTRAVRLNISYPPQNLTMTVFQGDGTASTTLRNGSALSVL 392
Query: 608 EGKSATLTCESDANPPVSHYTWFDWNNQSL-PYHSQK---LRLEPVKVQHSGAYWCQGTN 663
EG+S L C D+NPP + +W W + +L P S L L V V+ G + C+ N
Sbjct: 393 EGQSLHLVCAVDSNPP-ARLSW-TWGSLTLSPSQSSNLGVLELPRVHVKDEGEFTCRAQN 450
Query: 664 SVGKGRSPLS 673
+G LS
Sbjct: 451 PLGSQHISLS 460
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 84.3 bits (207), Expect = 4e-16
Identities = 118/542 (21%), Positives = 197/542 (36%), Gaps = 88/542 (16%)
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT---------------- 293
P D +V G+ + C + + + V W K G +L Q
Sbjct: 30 PEDLVVLLGEEARLPCALGAY---WGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQH 86
Query: 294 -LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVE---GSQV 349
L++R V + Y CQ + RS L V PE Q+L P+V G
Sbjct: 87 DLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAP--QVLGGPSVSLVAGVPA 142
Query: 350 EFLCMSLANPLPT-NYTWYHNGKEMQGRTEEKVHIPKILPWHA--------------GTY 394
C S + PT W+ +G + G T + + + P T+
Sbjct: 143 NLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATF 202
Query: 395 SCVAEN-ILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTR 453
C A + L TG R L +QYPP+ T+ +P ++EG+ V C ++ P VT
Sbjct: 203 VCRARSQALPTG-RDTAITLSLQYPPE--VTLSASPHTVQEGEKVIFLCQA-TAQPPVTG 258
Query: 454 YEWKPHGAWEEPSLGVLK-----IQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDV 508
Y W G+ P LG + + + ++C N+ S AL+V + P +
Sbjct: 259 YRWAKGGS---PVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP--I 313
Query: 509 RVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGS 568
K +P+S + G S C + + V + ++LG + L S+ PEDAG
Sbjct: 314 LQAKPEPVS-VDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGD 372
Query: 569 YSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYT 628
Y C + A + + ++ + G A L C A+P
Sbjct: 373 YVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPDAVV 431
Query: 629 WFDWNN-------------QSLPYHSQKLRLEP--VKVQH---------SGAYWCQGTNS 664
W W+ ++ P + L P + V H S ++ C N
Sbjct: 432 W-SWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNR 490
Query: 665 VGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQEN 724
+G+G + S P R+ G+ + L++ I G+ L W+ +++ E
Sbjct: 491 LGEGGAQASLGRRDLLPTV---RIVAGVAAATTTLLMVITGVAL-CCWRHSKASASFSEQ 546
Query: 725 SS 726
+
Sbjct: 547 KN 548
Score = 69.7 bits (169), Expect = 1e-11
Identities = 90/377 (23%), Positives = 145/377 (38%), Gaps = 48/377 (12%)
Query: 219 CQLQDADGKFLSNDTVQLNVKHTPKL-EIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTV 277
CQ A L + QL+V P+ ++ PS ++V G +TC +
Sbjct: 103 CQATQAG---LRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPANLTCRSRGDARPTPEL 158
Query: 278 SWLKDGT---------SLKKQNT-----FTLNLREVTKDQSGKYCCQVSNDVGP-GRSEE 322
W +DG +L K+ T TL L + D + C+ + P GR
Sbjct: 159 LWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTA 218
Query: 323 VFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVH 382
+ L +QY PE + H+ EG +V FLC + A P T Y W G + G ++
Sbjct: 219 ITLSLQYPPEVTLSASPHT-VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE 277
Query: 383 IPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSC 442
+ + SC N +G+ R LDV + P + P+ + G+ + SC
Sbjct: 278 VVADASFLTEPVSCEVSNAVGSANR--STALDVLFGP--ILQAKPEPVSVDVGEDASFSC 333
Query: 443 NYNSSNPSVTRYEWKPHGAWEEPSLG-VLKIQNVG----WDNTTIACAACNSWCSWASPV 497
+ NP + R W G + G L++ +VG D A A + A+
Sbjct: 334 AWR-GNP-LPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEA 391
Query: 498 ALNVQYAPRDVRVRKIKPLSEIHSG-----NSVSLQC-DFSSSHPKEVQFFWEKNGRLLG 551
L V P ++ +HS LQC F+S P V + W++ G
Sbjct: 392 RLTVNAPP---------VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAG 442
Query: 552 KESQLNFDSI-SPEDAG 567
+ + ++ +PE G
Sbjct: 443 SQGRFLVETFPAPESRG 459
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 84.3 bits (207), Expect = 4e-16
Identities = 118/542 (21%), Positives = 197/542 (36%), Gaps = 88/542 (16%)
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFT---------------- 293
P D +V G+ + C + + + V W K G +L Q
Sbjct: 30 PEDLVVLLGEEARLPCALGAY---WGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQH 86
Query: 294 -LNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVE---GSQV 349
L++R V + Y CQ + RS L V PE Q+L P+V G
Sbjct: 87 DLHIRPVELEDEASYECQATQ--AGLRSRPAQLHVLVPPEAP--QVLGGPSVSLVAGVPA 142
Query: 350 EFLCMSLANPLPT-NYTWYHNGKEMQGRTEEKVHIPKILPWHA--------------GTY 394
C S + PT W+ +G + G T + + + P T+
Sbjct: 143 NLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATF 202
Query: 395 SCVAEN-ILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTR 453
C A + L TG R L +QYPP+ T+ +P ++EG+ V C ++ P VT
Sbjct: 203 VCRARSQALPTG-RDTAITLSLQYPPE--VTLSASPHTVQEGEKVIFLCQA-TAQPPVTG 258
Query: 454 YEWKPHGAWEEPSLGVLK-----IQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDV 508
Y W G+ P LG + + + ++C N+ S AL+V + P +
Sbjct: 259 YRWAKGGS---PVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP--I 313
Query: 509 RVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGS 568
K +P+S + G S C + + V + ++LG + L S+ PEDAG
Sbjct: 314 LQAKPEPVS-VDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGD 372
Query: 569 YSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYT 628
Y C + A + + ++ + G A L C A+P
Sbjct: 373 YVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG-PARLQCLVFASPAPDAVV 431
Query: 629 WFDWNN-------------QSLPYHSQKLRLEP--VKVQH---------SGAYWCQGTNS 664
W W+ ++ P + L P + V H S ++ C N
Sbjct: 432 W-SWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNR 490
Query: 665 VGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQEN 724
+G+G + S P R+ G+ + L++ I G+ L W+ +++ E
Sbjct: 491 LGEGGAQASLGRRDLLPTV---RIVAGVAAATTTLLMVITGVAL-CCWRHSKASASFSEQ 546
Query: 725 SS 726
+
Sbjct: 547 KN 548
Score = 69.7 bits (169), Expect = 1e-11
Identities = 90/377 (23%), Positives = 145/377 (38%), Gaps = 48/377 (12%)
Query: 219 CQLQDADGKFLSNDTVQLNVKHTPKL-EIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTV 277
CQ A L + QL+V P+ ++ PS ++V G +TC +
Sbjct: 103 CQATQAG---LRSRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPANLTCRSRGDARPTPEL 158
Query: 278 SWLKDGT---------SLKKQNT-----FTLNLREVTKDQSGKYCCQVSNDVGP-GRSEE 322
W +DG +L K+ T TL L + D + C+ + P GR
Sbjct: 159 LWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTA 218
Query: 323 VFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVH 382
+ L +QY PE + H+ EG +V FLC + A P T Y W G + G ++
Sbjct: 219 ITLSLQYPPEVTLSASPHT-VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLE 277
Query: 383 IPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSC 442
+ + SC N +G+ R LDV + P + P+ + G+ + SC
Sbjct: 278 VVADASFLTEPVSCEVSNAVGSANR--STALDVLFGP--ILQAKPEPVSVDVGEDASFSC 333
Query: 443 NYNSSNPSVTRYEWKPHGAWEEPSLG-VLKIQNVG----WDNTTIACAACNSWCSWASPV 497
+ NP + R W G + G L++ +VG D A A + A+
Sbjct: 334 AWR-GNP-LPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEA 391
Query: 498 ALNVQYAPRDVRVRKIKPLSEIHSG-----NSVSLQC-DFSSSHPKEVQFFWEKNGRLLG 551
L V P ++ +HS LQC F+S P V + W++ G
Sbjct: 392 RLTVNAPP---------VVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAG 442
Query: 552 KESQLNFDSI-SPEDAG 567
+ + ++ +PE G
Sbjct: 443 SQGRFLVETFPAPESRG 459
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 84.0 bits (206), Expect = 5e-16
Identities = 102/387 (26%), Positives = 151/387 (39%), Gaps = 62/387 (16%)
Query: 335 TVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGR--------TEEKVHIPKI 386
TVQ + G V C+ P N TW NGKE+ G T + I +
Sbjct: 39 TVQPASTVQKPGGTVILGCV--VEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITAL 96
Query: 387 LPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS 446
G Y CVA G P K+ +Q+ + + EG+T ++C+
Sbjct: 97 NNHTVGRYQCVARMPAGAVASVPATVTLANLQDFKLD--VQHVIEVDEGNTAVIACHLPE 154
Query: 447 SNPSV-TRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSW----CSWASPVALNV 501
S+P RY K W E S G I G N I A+ C+ +PV V
Sbjct: 155 SHPKAQVRYSVKQE--WLEASRGNYLIMPSG--NLQIVNASQEDEGMYKCAAYNPVTQEV 210
Query: 502 QYAPRDVRVRKIKPLSE--------------IHSGNSVSLQCDFSSSHPKEVQFFWEKNG 547
+ + R+R + +E + G S+ L+C S P V W K+G
Sbjct: 211 KTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVT--WAKDG 268
Query: 548 RLLGKESQLNF-------DSISPEDAGSYSCWVNNSIGQTASKA--WTLEVLYAPRRLRV 598
+ ++ F D+ S ED+G+Y C +N +GQ + + ++V P V
Sbjct: 269 SSVTGYNKTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPP---EV 325
Query: 599 SMSPGDQVME-GKSATLTCESDANPPVSHYTWFDWNNQSLP-YHSQKLRLE-------PV 649
+M V+ G+SA LTCE NPP S W ++P SQ+LRL +
Sbjct: 326 TMELSQLVIPWGQSAKLTCEVRGNPPPSVL----WLRNAVPLISSQRLRLSRRALRVLSM 381
Query: 650 KVQHSGAYWCQGTNSVGKGRSPLSTLT 676
+ G Y C N VG + + T
Sbjct: 382 GPEDEGVYQCMAENEVGSAHAVVQLRT 408
Score = 35.8 bits (81), Expect = 0.17
Identities = 47/205 (22%), Positives = 78/205 (38%), Gaps = 25/205 (12%)
Query: 122 ESKTEKWMERIHLNVSERPFPPHIQLPPEIQ-----ESQEVTLTCLLNFSCYGYPIQLQW 176
E KT +R+ + S I PPE Q + Q + L C+ + P ++ W
Sbjct: 209 EVKTSGSSDRLRVRRSTAE-AARIIYPPEAQTIIVTKGQSLILECVASGIP---PPRVTW 264
Query: 177 LLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQL 236
+G ++VT + K+ F S L C + G+ +
Sbjct: 265 AKDG-----SSVTGYN---KTRFLLSNLLIDTTSEEDSGTYRCMADNGVGQ-PGAAVILY 315
Query: 237 NVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNL 296
NV+ E+ + S ++ G S +TCEV + P +V WL++ L L+
Sbjct: 316 NVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPP--PSVLWLRNAVPLISSQRLRLSR 373
Query: 297 R-----EVTKDQSGKYCCQVSNDVG 316
R + + G Y C N+VG
Sbjct: 374 RALRVLSMGPEDEGVYQCMAENEVG 398
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 83.2 bits (204), Expect = 9e-16
Identities = 75/243 (30%), Positives = 108/243 (44%), Gaps = 29/243 (11%)
Query: 238 VKHTPKLEIKV-------TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK-KQ 289
V H LE+ + PSD +V G+ M C+ +PE T+SW KDG+ L K
Sbjct: 118 VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE-PTISWKKDGSPLDDKD 176
Query: 290 NTFTLN-----LREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV 344
T+ + K +GKY C +N VG SE L V PS V+ + AV
Sbjct: 177 ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSFVKRPSNLAV 234
Query: 345 E-GSQVEFLCMSLANPLPTNYTWYHNGKEM-----QGRTEEKVHIPKILPWHAGTYSCVA 398
EF C + +P+PT W + E+ + R + + I K+ G+Y+CVA
Sbjct: 235 TVDDSAEFKCEARGDPVPT-VRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293
Query: 399 ENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
EN++G + A L VQ PP V V + G TVT C + NP + W+
Sbjct: 294 ENMVGKAE--ASATLTVQEPPHFV--VKPRDQVVALGRTVTFQCE-ATGNPQPAIF-WRR 347
Query: 459 HGA 461
G+
Sbjct: 348 EGS 350
Score = 60.5 bits (145), Expect = 7e-09
Identities = 93/392 (23%), Positives = 144/392 (36%), Gaps = 72/392 (18%)
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTS--------------LKKQNTFTLN 295
PSD IV +G+ T+ C+ + T+ W K G L + F L
Sbjct: 35 PSDLIVSKGEPATLNCK--AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 296 LREVTKDQ--SGKYCCQVSNDVGPGRSEEVFLQV-----QYAPEPSTVQI-LHSPAVEGS 347
+ K + G Y C N +G S L+V + PS V + + PAV
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
Query: 348 QVEFLCMSLANPLPTNYTWYHNGKEMQGRTEE------KVHIPKILPWHAGTYSCVAENI 401
Q +P PT +W +G + + E K+ I AG Y CV N+
Sbjct: 153 Q-----PPRGHPEPT-ISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 402 LGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWK---- 457
+G + AEL V P V + + + D+ C + V W+
Sbjct: 207 VGE-RESEVAELTVLERPSFVKR--PSNLAVTVDDSAEFKC--EARGDPVPTVRWRKDDG 261
Query: 458 --PHGAWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIK 514
P +E LKI+ V D + C A N + L VQ P V +K
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV----VK 317
Query: 515 PLSEIHS-GNSVSLQCDFSSSHPKEVQFFWEKNGR----------------LLGKESQLN 557
P ++ + G +V+ QC+ ++ +P+ FW + G + + L
Sbjct: 318 PRDQVVALGRTVTFQCE-ATGNPQPA-IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
Query: 558 FDSISPEDAGSYSCWVNNSIGQTASKAWTLEV 589
++ D G Y C N G +KA+ LEV
Sbjct: 376 ITNVQRSDVGYYICQTLNVAGSIITKAY-LEV 406
Score = 50.4 bits (119), Expect = 7e-06
Identities = 37/132 (28%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 562 SPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLTCESDA 620
S D G Y C N +G+ S +LEV R +P D V G+ A + C+
Sbjct: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR--QNPSDVMVAVGEPAVMECQPPR 156
Query: 621 NPPVSHYTW------FDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLST 674
P +W D ++ + KL + + +G Y C GTN VG+ S ++
Sbjct: 157 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 216
Query: 675 LTVYYSPETIGR 686
LTV P + R
Sbjct: 217 LTVLERPSFVKR 228
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 18/222 (8%)
Query: 522 GNSVSLQCDFSSSHPKEVQFFWEKNG--------RLLGKESQLNFDSISPEDAGSYSCWV 573
G ++C HP E W+K+G R+ + +L DAG Y C
Sbjct: 145 GEPAVMECQPPRGHP-EPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 574 NNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYTWFDW 632
N +G+ S+ L VL P V V SA CE+ +P P + D
Sbjct: 204 TNMVGERESEVAELTVLERPS--FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
Query: 633 NNQSLPYH---SQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETI--GRR 687
Y L++ V G+Y C N VGK + +TLTV P + R
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQEPPHFVVKPRD 320
Query: 688 VAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQS 729
V LG + A + W+R SQ L QS
Sbjct: 321 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 362
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 83.2 bits (204), Expect = 9e-16
Identities = 75/243 (30%), Positives = 108/243 (44%), Gaps = 29/243 (11%)
Query: 238 VKHTPKLEIKV-------TPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLK-KQ 289
V H LE+ + PSD +V G+ M C+ +PE T+SW KDG+ L K
Sbjct: 157 VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE-PTISWKKDGSPLDDKD 215
Query: 290 NTFTLN-----LREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAV 344
T+ + K +GKY C +N VG SE L V PS V+ + AV
Sbjct: 216 ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV--LERPSFVKRPSNLAV 273
Query: 345 E-GSQVEFLCMSLANPLPTNYTWYHNGKEM-----QGRTEEKVHIPKILPWHAGTYSCVA 398
EF C + +P+PT W + E+ + R + + I K+ G+Y+CVA
Sbjct: 274 TVDDSAEFKCEARGDPVPT-VRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 332
Query: 399 ENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKP 458
EN++G + A L VQ PP V V + G TVT C + NP + W+
Sbjct: 333 ENMVGKAE--ASATLTVQEPPHFV--VKPRDQVVALGRTVTFQCE-ATGNPQPAIF-WRR 386
Query: 459 HGA 461
G+
Sbjct: 387 EGS 389
Score = 60.5 bits (145), Expect = 7e-09
Identities = 93/392 (23%), Positives = 144/392 (36%), Gaps = 72/392 (18%)
Query: 250 PSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTS--------------LKKQNTFTLN 295
PSD IV +G+ T+ C+ + T+ W K G L + F L
Sbjct: 74 PSDLIVSKGEPATLNCK--AEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLR 131
Query: 296 LREVTKDQ--SGKYCCQVSNDVGPGRSEEVFLQV-----QYAPEPSTVQI-LHSPAVEGS 347
+ K + G Y C N +G S L+V + PS V + + PAV
Sbjct: 132 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 191
Query: 348 QVEFLCMSLANPLPTNYTWYHNGKEMQGRTEE------KVHIPKILPWHAGTYSCVAENI 401
Q +P PT +W +G + + E K+ I AG Y CV N+
Sbjct: 192 Q-----PPRGHPEPT-ISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
Query: 402 LGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWK---- 457
+G + AEL V P V + + + D+ C + V W+
Sbjct: 246 VGE-RESEVAELTVLERPSFVKR--PSNLAVTVDDSAEFKC--EARGDPVPTVRWRKDDG 300
Query: 458 --PHGAWEEPSLGVLKIQNV-GWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIK 514
P +E LKI+ V D + C A N + L VQ P V +K
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV----VK 356
Query: 515 PLSEIHS-GNSVSLQCDFSSSHPKEVQFFWEKNGR----------------LLGKESQLN 557
P ++ + G +V+ QC+ ++ +P+ FW + G + + L
Sbjct: 357 PRDQVVALGRTVTFQCE-ATGNPQPA-IFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
Query: 558 FDSISPEDAGSYSCWVNNSIGQTASKAWTLEV 589
++ D G Y C N G +KA+ LEV
Sbjct: 415 ITNVQRSDVGYYICQTLNVAGSIITKAY-LEV 445
Score = 50.4 bits (119), Expect = 7e-06
Identities = 37/132 (28%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 562 SPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGD-QVMEGKSATLTCESDA 620
S D G Y C N +G+ S +LEV R +P D V G+ A + C+
Sbjct: 138 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR--QNPSDVMVAVGEPAVMECQPPR 195
Query: 621 NPPVSHYTW------FDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLST 674
P +W D ++ + KL + + +G Y C GTN VG+ S ++
Sbjct: 196 GHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAE 255
Query: 675 LTVYYSPETIGR 686
LTV P + R
Sbjct: 256 LTVLERPSFVKR 267
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 18/222 (8%)
Query: 522 GNSVSLQCDFSSSHPKEVQFFWEKNG--------RLLGKESQLNFDSISPEDAGSYSCWV 573
G ++C HP E W+K+G R+ + +L DAG Y C
Sbjct: 184 GEPAVMECQPPRGHP-EPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 242
Query: 574 NNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANP-PVSHYTWFDW 632
N +G+ S+ L VL P V V SA CE+ +P P + D
Sbjct: 243 TNMVGERESEVAELTVLERPS--FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
Query: 633 NNQSLPYH---SQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETI--GRR 687
Y L++ V G+Y C N VGK + +TLTV P + R
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQEPPHFVVKPRD 359
Query: 688 VAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQS 729
V LG + A + W+R SQ L QS
Sbjct: 360 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 401
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,073,179
Number of Sequences: 37866
Number of extensions: 1830753
Number of successful extensions: 8612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 4553
Number of HSP's gapped (non-prelim): 2450
length of query: 847
length of database: 18,247,518
effective HSP length: 111
effective length of query: 736
effective length of database: 14,044,392
effective search space: 10336672512
effective search space used: 10336672512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.