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Search of human proteins with 110431348
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
(1447 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 2918 0.0
gi|157311649 neogenin homolog 1 [Homo sapiens] 1424 0.0
gi|83281200 protogenin [Homo sapiens] 278 2e-74
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 278 4e-74
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 274 4e-73
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 270 7e-72
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 268 4e-71
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 266 8e-71
gi|119220552 sidekick 1 [Homo sapiens] 265 2e-70
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 256 1e-67
gi|222352127 sidekick 2 [Homo sapiens] 251 4e-66
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 250 6e-66
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 234 3e-61
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 234 3e-61
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 233 1e-60
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 231 3e-60
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 231 3e-60
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 231 3e-60
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 225 2e-58
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 225 2e-58
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 218 3e-56
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 213 8e-55
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 209 2e-53
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 209 2e-53
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 208 3e-53
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 202 2e-51
gi|224994173 roundabout 1 isoform d [Homo sapiens] 201 3e-51
gi|224994171 roundabout 1 isoform c [Homo sapiens] 201 3e-51
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 201 3e-51
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 201 3e-51
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 2918 bits (7565), Expect = 0.0
Identities = 1447/1447 (100%), Positives = 1447/1447 (100%)
Query: 1 MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLD 60
MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLD
Sbjct: 1 MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLD 60
Query: 61 CSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEAS 120
CSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEAS
Sbjct: 61 CSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEAS 120
Query: 121 LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDL 180
LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDL
Sbjct: 121 LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDL 180
Query: 181 TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL 240
TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL
Sbjct: 181 TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL 240
Query: 241 YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV 300
YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV
Sbjct: 241 YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV 300
Query: 301 TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP 360
TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP
Sbjct: 301 TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP 360
Query: 361 TVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
TVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP
Sbjct: 361 TVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
Query: 421 AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT 480
AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT
Sbjct: 421 AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT 480
Query: 481 QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS 540
QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS
Sbjct: 481 QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS 540
Query: 541 PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA 600
PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA
Sbjct: 541 PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA 600
Query: 601 YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660
YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI
Sbjct: 601 YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660
Query: 661 RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL
Sbjct: 661 RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
Query: 721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY
Sbjct: 721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
Query: 781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL 840
YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL
Sbjct: 781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL 840
Query: 841 STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT 900
STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT
Sbjct: 841 STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT 900
Query: 901 TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP 960
TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP
Sbjct: 901 TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP 960
Query: 961 RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF 1020
RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF
Sbjct: 961 RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF 1020
Query: 1021 RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI 1080
RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI
Sbjct: 1021 RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI 1080
Query: 1081 GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGK 1140
GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGK
Sbjct: 1081 GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGK 1140
Query: 1141 RKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS 1200
RKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS
Sbjct: 1141 RKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS 1200
Query: 1201 KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ 1260
KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ
Sbjct: 1201 KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ 1260
Query: 1261 YPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH 1320
YPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH
Sbjct: 1261 YPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH 1320
Query: 1321 SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK 1380
SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK
Sbjct: 1321 SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK 1380
Query: 1381 TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLN 1440
TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLN
Sbjct: 1381 TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLN 1440
Query: 1441 AITGSAF 1447
AITGSAF
Sbjct: 1441 AITGSAF 1447
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 1424 bits (3685), Expect = 0.0
Identities = 747/1445 (51%), Positives = 1007/1445 (69%), Gaps = 55/1445 (3%)
Query: 28 QVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDE 87
Q G I+ FT FL EP D +++RG +V+L+CSA S+ P I+WKKDG L L D+
Sbjct: 41 QSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPS-PKIEWKKDGTFLNLVSDD 99
Query: 88 RKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTE 147
R+Q L +GSL I N++HS+H+KPDEG YQC A++ G+IISRTAK+ VAG RF SQ E
Sbjct: 100 RRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPE 159
Query: 148 SVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI 207
+ + G+ +L CEV + +P + W++N+Q P+ D RV+ LPSG L IS GD
Sbjct: 160 PSSVYAGNNAILNCEVNADLVPFVRWEQNRQ---PLLLDDRVIKLPSGMLVISNATEGDG 216
Query: 208 GIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYP 267
G+YRC + + +E E+++L DP + L FL++PS +V + G+D VL C SG P
Sbjct: 217 GLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP 276
Query: 268 PPSFTWLRGEEVIQLRS-KKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELT 326
P+ W++ EE + S ++ LL G +L IS+VT+DD+G Y C+ NE I A AELT
Sbjct: 277 TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELT 336
Query: 327 VLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLR 386
V P FL P+N+YA+ESMDI FEC V+GKP PTV W+KNGD+VIPSDYF+IV NL+
Sbjct: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQ 396
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446
+LG+VKSDEGFYQC+AEN+ GNAQ AQLI+ + A ++ LPSAPRDVV LVS+RF++
Sbjct: 397 VLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIK 456
Query: 447 LSWRPPA-EAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAY 505
L+WR PA + G+ T++VF+++EG RER NT+ PG +Q+T+ NL P +Y FRV+A
Sbjct: 457 LTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQ 516
Query: 506 NEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFC 565
N+ G GESS P++V TQPE+Q+PGP NL+A + SPTSI +TWE P NG +Q Y+L+
Sbjct: 517 NKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYY 576
Query: 566 TEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAP 625
E T KEQ+++V SY + GLKK+TEYS R +AYN++GPGVST D+ V TLSDVPSA
Sbjct: 577 MEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAA 636
Query: 626 PQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM-ETL-EPNNLWYLF 683
PQN+SLEV NS+SI + W PP TQNG ITGYKIR+RK +R+ ++ ETL L L
Sbjct: 637 PQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLI 696
Query: 684 TGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIM 743
GL++G++Y+F+V+A+T+NGTGP ++W +AET E+DLDE++VP+ PSSLHVRP I++
Sbjct: 697 EGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVV 756
Query: 744 SWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAG 803
SWTPP N NIVVRGY IGYG+GSP+A+T++VD KQRYY+IE L+ SSHYVI+LKAFNN G
Sbjct: 757 SWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVG 816
Query: 804 EGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVS 863
EG+PLYESA TR TD T VD + + + T VPD TPM+PPVGVQA L+HD +R++
Sbjct: 817 EGIPLYESAVTRPHTD-TSEVDLFVINAPY-TPVPD-PTPMMPPVGVQASILSHDTIRIT 873
Query: 864 WADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVT 923
WADNS+PK+QK ++ R YTVRW+T+ A+ KYK+ + T+LSY TGLKPNT+YEFSVMVT
Sbjct: 874 WADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVT 933
Query: 924 KNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILF 983
K RRSSTWSMTAH TT+E PTS PKD+TV+++EGKP+ +IV+WQPP EANGKIT YI++
Sbjct: 934 KGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIY 993
Query: 984 YTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLK 1043
Y+ D N I DW++E + G+RLTHQI +L LDT YYF+IQARNSKG+GP+S+ + FRT K
Sbjct: 994 YSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK 1053
Query: 1044 VEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIV 1103
+ DKM NDQ G GG + L D + +PP+ + PHGS T +SN+L++I+
Sbjct: 1054 ADSSDKMPNDQA-SGSGG---KGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVII 1109
Query: 1104 VTVGVITVLVVVIVAVICTRRSSAQQRKKRA----THSAGKRKGSQKDLRPPDLWIHHEE 1159
V+VGVIT++VVVI+AV CTRR+++ Q+KKRA + + K KG+ KD++PPDLWIHHE
Sbjct: 1110 VSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHER 1169
Query: 1160 MEMKNIEKPSGTDPAGRDSPI-QSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMS 1218
+E+K I+K +P D+PI ++ QD+TPV +S ++ + + S+ G ++E+ SMS
Sbjct: 1170 LELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSM-DSNIHQRRNSYRGHESED---SMS 1225
Query: 1219 TLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ---YPGILPSPTCGY-PH 1274
T LA RR R K+M+P D+Q P V+SA P+ +L++ + L SP + H
Sbjct: 1226 T----LAGRRGMRPKMMMPFDSQPPQP-VISAHPIHSLDNPHHHFHSSSLASPARSHLYH 1280
Query: 1275 PQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTT---------------QQPPMLPPSQPE 1319
P P P T S+ A ++SV P+T Q P S
Sbjct: 1281 PG---SPWPIGT-SMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYL 1336
Query: 1320 HSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPP-MSAIEPKVPYTPLLSQPGPTLPKTH 1378
SS EE +++PTA VRP+HPL+SFA P +PPP +P +P TPLLSQ
Sbjct: 1337 ASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHS 1396
Query: 1379 VKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQ 1438
VKTAS+G G++R P +PV VP+APEV +E+ + EDS + YE D+L+++MA LEGLMK
Sbjct: 1397 VKTASIGTLGRSRPP-MPVVVPSAPEV-QETTRMLEDSESSYEPDELTKEMAHLEGLMKD 1454
Query: 1439 LNAIT 1443
LNAIT
Sbjct: 1455 LNAIT 1459
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 278 bits (712), Expect = 2e-74
Identities = 251/878 (28%), Positives = 387/878 (44%), Gaps = 83/878 (9%)
Query: 37 FTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPV-IKWKKDGIHLALGMDERKQQLSNG 95
F+ L F+ EP D R V+LDC A + VP+ + W K+G ++ ++R + LSNG
Sbjct: 36 FSELSFVKEPQDVTVTRKDPVVLDCQAHGE--VPIKVTWLKNGAKMS--ENKRIEVLSNG 91
Query: 96 SLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGD 155
SL I + R + DEG YQC A + G+I+S+ A +A++ F Q S G
Sbjct: 92 SLYISEVEGRRGEQSDEGFYQCLA-MNKYGAILSQKAHLALSTISAFEVQPISTEVHEGG 150
Query: 156 TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSAR 215
C++ P I W+ N+ L P+ D R+ LP+G LQI + D G YRC A
Sbjct: 151 VARFACKISSHPPAVITWEFNRTTL-PMTMD-RITALPTGVLQIYDVSQRDSGNYRCIAA 208
Query: 216 NPASSRTGNEAEVRILSDPGLHRQLY----FLQRPSNVVAIEGKDAVLECCVSGYPPPSF 271
A R EA + ++ P + + + P N+ + VLEC +G P P
Sbjct: 209 TVAHRRKSMEASLTVI--PAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPII 266
Query: 272 TWLRGE----EVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTC-VVTYKNENIS-ASAEL 325
+W R + +V R +LG NL+IS+V +G+Y C T N + A A L
Sbjct: 267 SWSRLDHKSIDVFNTR-----VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATL 321
Query: 326 TVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNL 385
TVL PP F+ P +L + F C G P P ++W+KNG + + ++ S L
Sbjct: 322 TVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMY-NSKL 380
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
I ++ D+ YQC+AEN G+ + A+L + S PSAP +V +SS +
Sbjct: 381 VINQIIPEDDAIYQCMAENSQGSILSRARL-----TVVMSEDRPSAPYNVHAETMSSSAI 435
Query: 446 RLSWRPPAEAKGNIQTFTVFFSR-EGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
L+W P + ++V + + EG N E + + +L+P + YTF +VA
Sbjct: 436 LLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVA 495
Query: 505 YNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP-PA-YANGPVQGYR 562
Y G + S + T ++ + P + S SPT ILI+W P PA Y G V YR
Sbjct: 496 YMPMGASQMSDHVTQNTLEDVPLRPP--EISLTSRSPTDILISWLPIPAKYRRGQVVLYR 553
Query: 563 LFCTEVSTGKEQNIEVDGLS--YKLEGLKKFTEYSLRFLAYNRYGPGVS----TDDITVV 616
L + Q +E+ G + Y LEGLK + Y +R A R G G S +
Sbjct: 554 LSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKA 613
Query: 617 TLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET--- 673
T P +P + LE +N +I V W T I GYK+ +++ G+ E
Sbjct: 614 TSVKAPKSP--ELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKE---EGQQENGPI 666
Query: 674 -LEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPE-NDLDESQVPDQPSS 731
L+ +L Y +GL+ +Y ++ A G ++ T TP + + VP P
Sbjct: 667 FLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD-QTVSTPGCVSVRDRMVPPPPPP 725
Query: 732 LHVRPQTN---CIIMSWTPPLNPNIVVRGYIIGYG-VGSPYAETV-RVDSKQRYYSIERL 786
H+ + N I + W P + Y I VG A V + + + + ++ L
Sbjct: 726 HHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGL 785
Query: 787 ESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLP 846
E ++ Y +++ ++ P PV Y+ L + P P
Sbjct: 786 EPNTKYEFAVRLH--------------VDQLSSPWSPVVYHSTLPEAPAG---------P 822
Query: 847 PVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
PVGV+ + D VSW P+ T LY R
Sbjct: 823 PVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASR 860
Score = 239 bits (609), Expect = 2e-62
Identities = 247/1028 (24%), Positives = 415/1028 (40%), Gaps = 92/1028 (8%)
Query: 140 LRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQI 199
L F+ + + VT D V+L C+ GE + W KN ++ + R+ VL +G+L I
Sbjct: 39 LSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSE---NKRIEVLSNGSLYI 95
Query: 200 SRLQ-----PGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEG 254
S ++ D G Y+C A N + +A + + + Q P + EG
Sbjct: 96 SEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQ------PISTEVHEG 149
Query: 255 KDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVV-T 313
A C +S +PP TW + + + + L L I +V+ DSG Y C+ T
Sbjct: 150 GVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAAT 209
Query: 314 YKNENISASAELTVLVP--------PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWM 365
+ S A LTV+ P + P N+ + EC +G P P ++W
Sbjct: 210 VAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWS 269
Query: 366 KNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSS 425
+ I +++G NL I V G Y C A T A + A PS
Sbjct: 270 RLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSF 329
Query: 426 SVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSL 485
P + P ++RFV + P+ ++ S + R + N+
Sbjct: 330 VEWPESLTR--PRAGTARFVCQAEGIPSPKMSWLKNGRKIHS---NGRIKMYNS------ 378
Query: 486 QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSIL 545
+L + + PE ++ +A N G S + V + P N+ A + S ++IL
Sbjct: 379 KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDR--PSAPYNVHAETMSSSAIL 436
Query: 546 ITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV----DGLSYKLEGLKKFTEYSLRFLAY 601
+ WE P Y + V Y + + + +V D Y ++ L+ + Y+ +AY
Sbjct: 437 LAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAY 496
Query: 602 NRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR 661
G +D +T TL DVP PP+ +SL + I +SWLP P+ + G + Y++
Sbjct: 497 MPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLYRLS 555
Query: 662 HRKTTRRG-EMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
R +T ++ L YL GL+ S Y +++A T G G S W + TP+
Sbjct: 556 FRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPK--A 613
Query: 721 DESQVPDQPSSLHVRPQTNCIIMS--WTPPLNPNIVVRGYIIGYGV-GSPYAETVRVDSK 777
+ P P LH+ P NC +S W + ++GY + Y G + +D+K
Sbjct: 614 TSVKAPKSPE-LHLEP-LNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTK 671
Query: 778 QRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSV 837
Y++ L+ Y + L A+NN +G ++ +T D + V
Sbjct: 672 DLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRM------------V 719
Query: 838 PDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKS 897
P P PP + A A T ++ + W + +++ YT+R +A
Sbjct: 720 P----PPPPPHHLYAKANTSSSIFLHWRRPAFT----AAQIINYTIRCNPVGLQNASLVL 771
Query: 898 EDTTSLSYTAT-GLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITR 956
TS ++ GL+PNT YEF+V + ++ SS WS + +T AP P + V
Sbjct: 772 YLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLI 831
Query: 957 EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDT 1016
E +VSW+PP +T Y + Y K +W + G + +L
Sbjct: 832 EDD--TALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGN 889
Query: 1017 MYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLN 1076
+Y +I A N G GP S+ + L E + +N + + D V +
Sbjct: 890 VYIVKISASNEVGEGPFSNSVELAVLPKETSE--SNQRPKRLDSADAKVYS--------- 938
Query: 1077 EPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATH 1136
G H S+T + V + + + I + V++++ R+SSA + + T
Sbjct: 939 ----GYYHLDQKSMT-----GIAVGVGIALTCILICVLILIYRSKARKSSASKTAQNGTQ 989
Query: 1137 SAGKRKGS 1144
+ S
Sbjct: 990 QLPRTSAS 997
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 278 bits (710), Expect = 4e-74
Identities = 278/1069 (26%), Positives = 452/1069 (42%), Gaps = 128/1069 (11%)
Query: 17 LFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPV--IKW 74
L G++ + A + V G + A+R ++ + G + L++C G P IKW
Sbjct: 550 LVGSAEYQARINVRG--PPSIRAMRNIT------AVAGRDTLINCRVI---GYPYYSIKW 598
Query: 75 KKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKV 134
KD L L + R+ NG+L + ++ DEG Y C + SI S++ V
Sbjct: 599 YKDA--LLLPDNHRQVVFENGTLKLTDVQKGM----DEGEYLCSVLIQPQLSI-SQSVHV 651
Query: 135 AVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT-IHWQKNQQDLTPIPGDSRVVVLP 193
AV P + E A +G + + C V MP I W+K+ Q + G +
Sbjct: 652 AVKVP-PLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEF 710
Query: 194 SGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIE 253
+LQIS + G Y C A N A++ E ++ + P F+ +P+N I
Sbjct: 711 MSSLQISSVSLKHNGNYTCIASNAAAT-VSRERQLIVRVPPR------FVVQPNNQDGIY 763
Query: 254 GKDAVLECCVSGYPPPSFTWLRGE--------EVIQLRSKKYSLLGGSNLLISNVTDDDS 305
GK VL C V GYPPP W + + L + +L S+LLI +V ++D
Sbjct: 764 GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR-IQILPNSSLLIRHVLEEDI 822
Query: 306 GMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNW 364
G Y C + +IS S LTV +P +HP+ A + E CT G+ + W
Sbjct: 823 GYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
Query: 365 MKNGDVVIPSDYFQIVGG---------SNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL 415
K V+ P + S L++ + D F+ C A N G + QL
Sbjct: 883 EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL 942
Query: 416 IVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRE- 474
V +P P + V +R + L W + I F + + + D+ +
Sbjct: 943 TVQEPPDPPELEIRE---------VKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDF 993
Query: 475 -RALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVEN 533
++ P Q + +L P ++Y+ R+ ++N+ G E S+ + ++T+ E GP +
Sbjct: 994 KQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTE-EAAPDGPPMD 1052
Query: 534 LQAVSTSPTSILITWEPPA--YANGPVQGYRLFCTEVSTGKEQNIEV-------DGLSYK 584
+ + SI +TW+ P NG ++GY++ E S G + D Y
Sbjct: 1053 VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYT 1112
Query: 585 LEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWL 644
L+ LKKF +Y + A+NR G G S+ +I TL DVPS PP+NV + S +SW
Sbjct: 1113 LDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWS 1172
Query: 645 PPPSGTQNGFITGYKIRHRK---TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTV 701
PP T NG + GY++ GEM+ + G+EK + YS QV A T
Sbjct: 1173 EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232
Query: 702 NGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII 760
G G S+ +T E+ VP P+ + P + + +++SW PP PN V+R Y I
Sbjct: 1233 AGDGVRSSVLYIQTKED------VPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTI 1286
Query: 761 ---GYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSI 817
G G P +Q +Y I L Y++ + A +AG G ++ +
Sbjct: 1287 FCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG------NSSEKV 1340
Query: 818 TDPTDPVDYYPL-LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWA----DNSVPKN 872
T +P P + F +V +TP + V + ++ A V W D+++P +
Sbjct: 1341 T--IEPAGKAPAKIISFGGTV---TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVS 1395
Query: 873 QKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWS 932
RL A K+ED+ + TAT NT +++V
Sbjct: 1396 MDGH--RLIHTNGTLLLRA---VKAEDSGYYTCTAT----NTGGFDTIIV---------- 1436
Query: 933 MTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPI 992
P P+ LTV + ++ ++W P I ++L Y++D +
Sbjct: 1437 -----NLLVQVPPDQPR-LTV--SKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNS--- 1485
Query: 993 DDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
++W IS + ++ L T Y ++ A+NS G G +S+ I +T
Sbjct: 1486 EEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKT 1534
Score = 129 bits (323), Expect = 3e-29
Identities = 229/1033 (22%), Positives = 390/1033 (37%), Gaps = 131/1033 (12%)
Query: 54 GGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEG 113
G V L C+A S +P I+W KDG L D R + G L I ++ D G
Sbjct: 300 GHTVELPCTA-SGYPIPAIRWLKDG--RPLPADSRWTKRITG-LTISDL-----RTEDSG 350
Query: 114 LYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHW 173
Y CE + ++ T + V PL + + +G TV+L C + G P TI W
Sbjct: 351 TYICEVT--NTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRW 408
Query: 174 QKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSD 233
+N + + P S + L + L I+ Q G Y+C A A +T + + L D
Sbjct: 409 YRNTELVLPDEAIS-IRGLSNETLLITSAQKSHSGAYQCFATRKA--QTAQDFAIIALED 465
Query: 234 PGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI----QLRSKKYSL 289
G R + S V G+ L C G PPP+ TW +E I R+ +Y++
Sbjct: 466 -GTPR---IVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTM 521
Query: 290 LGGSNLLISNVTDD---DSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESM 346
G+ + NVT D G+Y C + A + V PP + N+ A
Sbjct: 522 SDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPP-SIRAMRNITAVAGR 580
Query: 347 DIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNLRILGVVKS-DEGFYQC--VA 402
D C V G P ++ W K+ +++P ++ Q+V L++ V K DEG Y C +
Sbjct: 581 DTLINCRVIGYPYYSIKWYKDA-LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLI 639
Query: 403 ENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDV--VPVLVSS--RFVRLSWRPPAEAKGN 458
+ + +Q+ + P I P++ + +P +VSS +R++WR +
Sbjct: 640 QPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQ---- 695
Query: 459 IQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIK 518
V S G E + SLQ++ +LK YT +A N + +
Sbjct: 696 -----VIISGSGVTIE---SKEFMSSLQISSVSLKHNGNYT--CIASNAAATVSRERQLI 745
Query: 519 VATQPELQV-PGPVENLQAVSTSPTSILITWEPP------AYANGPVQGYRLFCTEVSTG 571
V P V P + + + + + PP A +G Q Y TG
Sbjct: 746 VRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYH---PVPLTG 802
Query: 572 KEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPP----- 626
+ Q + L + L++ Y L A N G +S V + + ++ P
Sbjct: 803 RIQILPNSSLLIR-HVLEEDIGYYL-CQASNGVGTDISKSMFLTVKIPAMITSHPNTTIA 860
Query: 627 -----QNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWY 681
+ ++ R I + W + + Y I T+ E + L
Sbjct: 861 IKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAI----ATKDNGDEVVSTLKL-- 914
Query: 682 LFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCI 741
++G F A+ G T + P PD P + +
Sbjct: 915 --KPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP---------PDPPELEIREVKARSM 963
Query: 742 IMSWTPPLNPNIVVRGYIIGYGVGSP----YAETVRVDSKQRYYSIERLESSSHYVISLK 797
+ WT + N ++ G+ I Y S T + +I L +S Y I +
Sbjct: 964 NLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMY 1023
Query: 798 AFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTH 857
+FN G P ++ +T T+ + P PP+ V +T
Sbjct: 1024 SFNKIGRSEP------SKELTISTEE-----------------AAPDGPPMDVTLQPVTS 1060
Query: 858 DAVRVSWADNSVPKNQKTSEVRLYTVRWR-TSFSASAKYKSEDTTSLS----YTATGLKP 912
+++V+W + K + +R Y + +R S ++ +Y + + YT LK
Sbjct: 1061 QSIQVTW--KAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
Query: 913 NTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLE 972
Y V + S +ATT E P+ P+++ ++ ++SW P
Sbjct: 1119 FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPR 1176
Query: 973 A--NGKITAY-ILFYTLDKNIPIDDW-IMETISGDRLTHQIMDLNLDTMYYFRIQARNSK 1028
+ NG + Y ++F++L + +W M+ I+ R ++ + T Y ++ A
Sbjct: 1177 STLNGVLKGYRVIFWSLYVD---GEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQA 1233
Query: 1029 GVGPLSDPILFRT 1041
G G S + +T
Sbjct: 1234 GDGVRSSVLYIQT 1246
Score = 103 bits (257), Expect = 1e-21
Identities = 111/427 (25%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 13 LAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGG-NVLLDCSAESDRGVPV 71
+ F+L SL A + G T+L F+++ VT V++ C A
Sbjct: 64 VTFLLLLDSLHKARPEDVG------TSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSA-A 116
Query: 72 IKWKKDGIHLALGMD-----ERKQQLSNGSLLIQ----NILHSRHHKPDEGLYQCEASLG 122
++W +LA G D + +NG+L + + +S H D Y C A
Sbjct: 117 LRW-----YLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND---YFCTAE-N 167
Query: 123 DSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEV---IGEPMPTIHWQKNQQD 179
+G I S +V + + E + G+ + KC + + E + + W+K+
Sbjct: 168 AAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVS 227
Query: 180 LTPIPGDSRVVVLPSGALQISRLQPGD-IGIYRCSARNPASSRTGNEAEVRI-LSDP--- 234
+ P + R + G L IS +Q D + YRC ++ S T R+ ++DP
Sbjct: 228 IIP---EHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAES 284
Query: 235 ------GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYS 288
G H Q + G L C SGYP P+ WL+ + S+
Sbjct: 285 IPTILDGFHSQEVWA----------GHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTK 334
Query: 289 LLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDI 348
+ G L IS++ +DSG Y C VT + A+ L V+ P P L +
Sbjct: 335 RITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTV 392
Query: 349 EFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSN--LRILGVVKSDEGFYQCVAENEA 406
C ++G P T+ W +N ++V+P + I G SN L I KS G YQC A +A
Sbjct: 393 ILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKA 452
Query: 407 GNAQTSA 413
AQ A
Sbjct: 453 QTAQDFA 459
Score = 43.1 bits (100), Expect = 0.002
Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 14/207 (6%)
Query: 525 LQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDG--LS 582
+QVP L TS +SI +TW P ++G+ L + ++ + +++ + S
Sbjct: 1440 VQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
Query: 583 YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVS 642
+KL+ LK T Y ++ A N G G ++ I T PS +NS +++
Sbjct: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559
Query: 643 WLPPPSGTQNGF--ITGYKIRHRKTTRRGEMETLEPNNLWYLF-TGLEKGSQYSFQVSAM 699
G NG IT + +R + L N+ +F T L + + Y ++ A
Sbjct: 1560 L----QGWNNGGCPITAIVLEYR-PKGTWAWQGLRANSSGEVFLTELREATWYELRMRAC 1614
Query: 700 TVNGTGPPSNWYTAETPENDLDESQVP 726
G G TA+ D D S +P
Sbjct: 1615 NSAGCGNE----TAQFATLDYDGSTIP 1637
Score = 37.4 bits (85), Expect = 0.11
Identities = 37/140 (26%), Positives = 60/140 (42%), Gaps = 10/140 (7%)
Query: 910 LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQP 969
L P ++Y + S S +T EAAP P D+T+ + +++ V+W+
Sbjct: 1012 LHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKA 1069
Query: 970 PLEA--NGKITAYILFYTLDKNIPIDDWIMETI----SGDRLTHQIMDLNLDTMYYFRIQ 1023
P + NG I Y + Y +N P + + +GD + + +L Y +Q
Sbjct: 1070 PKKELQNGVIRGYQIGYR--ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQ 1127
Query: 1024 ARNSKGVGPLSDPILFRTLK 1043
A N G GP S I TL+
Sbjct: 1128 AFNRAGTGPSSSEINATTLE 1147
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 274 bits (701), Expect = 4e-73
Identities = 299/1063 (28%), Positives = 445/1063 (41%), Gaps = 131/1063 (12%)
Query: 36 AFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ--QLS 93
A T RF P D + GG C A D P I W K G ++ ++R + +
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPR-PKIVWNKKGKKVS---NQRFEVIEFD 75
Query: 94 NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF- 152
+GS + I R + DE +Y+C AS + +++V+ L L + + F
Sbjct: 76 DGSGSVLRIQPLRTPR-DEAIYECVAS--------NNVGEISVSTRLTVLREDQIPRGFP 126
Query: 153 ---MGD---------TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQIS 200
MG T + C G P P I W K+ + + R+ L SGALQI
Sbjct: 127 TIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIE 186
Query: 201 RLQPGDIGIYRCSARNPASSRTGNEAE--VRILSDPGLHRQLYFLQRPSNVVAIEGKDAV 258
+ + D G Y C A N A +R A VR+ P F P+N + G
Sbjct: 187 QSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPR-----FSIPPTNHEIMPGGSVN 241
Query: 259 LECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNEN 318
+ C G P P W+ G E L + +G + L +++V S YTCV
Sbjct: 242 ITCVAVGSPMPYVKWMLGAE--DLTPEDDMPIGRNVLELNDVRQ--SANYTCVAMSTLGV 297
Query: 319 ISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWM-----KNGDVVI 372
I A A++TV P P ES T SG P P ++ KN + +
Sbjct: 298 IEAIAQITVKALP---KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEL- 353
Query: 373 PSDYFQIVGGSNLR--ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPS 430
Y +I G + R + G+ + ++ VA N G S ++ S S
Sbjct: 354 ---YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT----SEQAPSS 406
Query: 431 APRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLT-V 489
APRDV ++SS + + W+ P E G IQ + V+++ + Q+T +
Sbjct: 407 APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI 466
Query: 490 GNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWE 549
GNL P+ Y+ +V+A+ G G S I+V TQ VPG N +A S TSIL++W
Sbjct: 467 GNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG--VPGQPLNFKAEPESETSILLSWT 524
Query: 550 PPAYANGPVQGYRLFCTEVSTGKEQNIEVD-GLSYKLEGLKKFTEYSLRFLAYNRYGPGV 608
PP + + Y L + G+EQ I ++ G SY+L+GLK + Y R A + G G
Sbjct: 525 PPR--SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGA 582
Query: 609 STDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR----K 664
ST +I+ T+ PSAPPQ++S +S SI VSW PPP QNG IT Y I++ +
Sbjct: 583 STAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 642
Query: 665 TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQ 724
+ E+ + + YL LEK ++Y V+A T G GP S T E+
Sbjct: 643 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED------ 696
Query: 725 VPD-QPSSLHVRP-QTNCIIMSWTPPLNPNI---VVRGYIIGY-------GVGSPYAETV 772
VP P + V + + +SW P+ PN +RGY + Y G P + V
Sbjct: 697 VPSGPPRKVEVEAVNSTSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDV 755
Query: 773 RV--------DSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPV 824
+ D+ + I L+ + Y +++ A+ G+G + + + T V
Sbjct: 756 MLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG-----ARSKPKLVSTTGAV 810
Query: 825 DYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
P L T + PPV D P + +
Sbjct: 811 PGKPRLVINHTQMNTALIQWHPPV-----------------DTFGPLQGYRLKFGRKDME 853
Query: 885 WRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
T+ S K ED +TAT + Y F + +N+ M + E P
Sbjct: 854 PLTTLEFSEK---ED----HFTATDIHKGASYVFR-LSARNKVGFGEEMVKEISIPEEVP 905
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPL--EANGKITAYILFYTLDKNIPIDDWIMETISG 1002
T P++L + +V +SWQPP+ E NG IT Y L Y D NIP+ +
Sbjct: 906 TGFPQNLH--SEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINIPLLPMEQLIVPA 962
Query: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVE 1045
D T + L DT Y +++A SKG GP S + FRTL V+
Sbjct: 963 D-TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1004
Score = 150 bits (379), Expect = 9e-36
Identities = 213/906 (23%), Positives = 343/906 (37%), Gaps = 135/906 (14%)
Query: 242 FLQRPSNVVAIEGKDAVLECCVSGYPPPSFTW-LRGEEVIQLRSKKYSLLGGSNLLISNV 300
F + P + + G A C +G P P W +G++V R + GS ++
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 301 ---TDDDSGMYTCVVTYKNENISASAELTVL----VPPWFLN---HPSNLYAYESMDIEF 350
T D +Y CV + IS S LTVL +P F P +
Sbjct: 86 PLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATM 145
Query: 351 ECTVSGKPVPTVNWMKNGDVVIPSD----YFQIVGGSNLRILGVVKSDEGFYQCVAENEA 406
C SG P P + W K+ V S+ Q+ G+ L+I +SD+G Y+CVA N A
Sbjct: 146 LCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGA-LQIEQSEESDQGKYECVATNSA 204
Query: 407 G-------NAQTSAQLIVPKPAIPSSS--VLPSAPRDVVPVLVSSRFVRLSWRPPAEAKG 457
G N + + P+ +IP ++ ++P ++ V V S + W AE
Sbjct: 205 GTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAED-- 262
Query: 458 NIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPI 517
+ E D G L + +++ A YT VA + G E+ I
Sbjct: 263 --------LTPEDD--------MPIGRNVLELNDVRQSANYT--CVAMSTLGVIEAIAQI 304
Query: 518 KVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIE 577
V P+ P ++ TSI +TW+ N Y + + +E E
Sbjct: 305 TVKALPK-----PPGTPVVTESTATSITLTWDS---GNPEPVSYYIIQHKPKNSEELYKE 356
Query: 578 VDGLS---YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV 634
+DG++ Y + GL +++Y R +A N G G ++ + T PS+ P++V ++
Sbjct: 357 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARML 416
Query: 635 NSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFT---GLEKGSQ 691
+S +I V W P NG I GY++ + + ++ N T L
Sbjct: 417 SSTTILVQWKEPEE--PNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKT 474
Query: 692 YSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNC-IIMSWTPPLN 750
YS +V A T G GP S+ T ++ VP QP + P++ I++SWTPP +
Sbjct: 475 YSVKVLAFTSIGDGPLSSDIQVIT------QTGVPGQPLNFKAEPESETSILLSWTPPRS 528
Query: 751 PNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYE 810
I Y + Y G E Y ++ L+ +S Y L A + G G
Sbjct: 529 DTIA--NYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG----- 581
Query: 811 SATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVP 870
A+T I+ T S P PP + + + ++ VSW V
Sbjct: 582 -ASTAEISARTMQ-----------------SKPSAPPQDISCTSPSSTSILVSWQPPPVE 623
Query: 871 KNQKTSEVRLYTVRWRTSFSASAKYKS-----EDTTSLSYTATGLKPNTMYEFSVMVTKN 925
K + + Y++++ K DTT Y L+ T Y +V +
Sbjct: 624 K--QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTK--YLLEQLEKWTEYRITVTAHTD 679
Query: 926 RRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPL--EANGKITAYILF 983
S++ T E P+ P+ + V +V VSW+ P+ + +G+I Y +
Sbjct: 680 VGPGPESLSVLIRTNEDVPSGPPRKVEV--EAVNSTSVKVSWRSPVPNKQHGQIRGYQVH 737
Query: 984 YT-LDKNIPIDDWIMETIS--------GDRLTHQ--IMDLNLDTMYYFRIQARNSKGVGP 1032
Y ++ P +++ + D H I L +T Y + A +KG G
Sbjct: 738 YVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGA 797
Query: 1033 LSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTP 1092
S P L T G P L+ T + Q HPP + P
Sbjct: 798 RSKPKLVSTT------------------GAVPGKPRLVINHTQMNTALIQWHPPVDTFGP 839
Query: 1093 QKNSNL 1098
+ L
Sbjct: 840 LQGYRL 845
Score = 103 bits (257), Expect = 1e-21
Identities = 112/415 (26%), Positives = 167/415 (40%), Gaps = 37/415 (8%)
Query: 422 IPSSSVLPSAP-RDVVPVLVSSRFVRLSWRPPAEAK--GNIQTFTVFFSREGDNRERALN 478
I ++ +PS P R V V+S V++SWR P K G I+ + V + R + +
Sbjct: 691 IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQP 750
Query: 479 TTQPGSL-------------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPEL 525
+ L + + L+PE Y+ V AY G G S+P V+T
Sbjct: 751 MLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA- 809
Query: 526 QVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLS--Y 583
VPG L T + LI W PP GP+QGYRL +E +
Sbjct: 810 -VPGK-PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHF 867
Query: 584 KLEGLKKFTEYSLRFLAYNRYGPGVS-TDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVS 642
+ K Y R A N+ G G +I++ +VP+ PQN+ E S S+++S
Sbjct: 868 TATDIHKGASYVFRLSARNKVGFGEEMVKEISIP--EEVPTGFPQNLHSEGTTSTSVQLS 925
Query: 643 WLPPPSGTQNGFITGYKIRHR--KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMT 700
W PP +NG IT Y + +R + + P + TGL+ + Y +V A T
Sbjct: 926 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 985
Query: 701 VNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRGYI 759
G GP Y+ L QV + HV+ +++SW P N N + I
Sbjct: 986 SKGPGP----YSPSVQFRTLPVDQV--FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKI 1039
Query: 760 IGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATT 814
+ Y G E VD + I L+ Y L N+ G+ +A T
Sbjct: 1040 L-YDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1090
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 270 bits (690), Expect = 7e-72
Identities = 267/1014 (26%), Positives = 421/1014 (41%), Gaps = 114/1014 (11%)
Query: 72 IKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRT 131
IKW K+ L + + +NG+L + ++ + DEG Y C + S S++
Sbjct: 535 IKWYKNSNLLPFNHRQVAFE-NNGTLKLSDV----QKEVDEGEYTCNVLVQPQLST-SQS 588
Query: 132 AKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMP-TIHWQKNQQDLTPIPGDSRVV 190
V V P F+ E +G V + C V+ +P TI WQK D PIPG V
Sbjct: 589 VHVTVKVP-PFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQK---DGRPIPGSLGVT 644
Query: 191 VLP---SGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPS 247
+ + +L+IS L G Y C ARN A++ +++++ + P F+ +P
Sbjct: 645 IDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA-VEHQSQLIVRVPPK------FVVQPR 697
Query: 248 NVVAIEGKDAVLECCVSGYPPPSFTWL--RGEEVIQLR----SKKYSLLGGSNLLISNVT 301
+ I GK +L C GYP P+ W +G V Q + + + +L +LLI +V
Sbjct: 698 DQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVV 757
Query: 302 DDDSGMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP 360
++DSG Y C V+ ++S S LTV +P ++P+ A + E CT G+
Sbjct: 758 EEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI 817
Query: 361 TVNWMKNGDVVIPSDYFQIVGG--------SNLRILGVVKSDEGFYQCVAENEAGNAQTS 412
V W K ++ P +V S L+IL V+ D GF+ C A N G +
Sbjct: 818 IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGI 877
Query: 413 AQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDN 472
QL V +P P + V +R + L W + I + + + D+
Sbjct: 878 IQLTVQEPPDPPEIEIKD---------VKARTITLRWTMGFDGNSPITGYDIECKNKSDS 928
Query: 473 RERALNT--TQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGP 530
+ A T P T+ ++ P + Y+ R+ A N G E S + + T E GP
Sbjct: 929 WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTI-TADEAAPDGP 987
Query: 531 VENLQAVSTSPTSILITWEPPA--YANGPVQGYRLFCTEVSTGKEQNIEV-------DGL 581
+ + S SI +TW+ P NG ++GY++ E STG + D
Sbjct: 988 PQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE 1047
Query: 582 SYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKV 641
Y L+ L KFT+Y L A NR G G S+ +I TL DVPS PP+NV + SI +
Sbjct: 1048 VYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISI 1107
Query: 642 SWLPPPSGTQNGFITGYKIRHRKTTRRGEM------ETLEPNNLWYLFTGLEKGSQYSFQ 695
SW NG + G+++ + GE+ T +P+ GLEK + YS Q
Sbjct: 1108 SWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS---LELDGLEKYTNYSIQ 1164
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLH-VRPQTNCIIMSWTPPLNPNIV 754
V A T G G S T E+ VP P+ + + + +SW PPL N +
Sbjct: 1165 VLAFTRAGDGVRSEQIFTRTKED------VPGPPAGVKAAAASASMVFVSWLPPLKLNGI 1218
Query: 755 VRGYIIGYGVGSPYAETV---RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYES 811
+R Y + PY + Y I L + Y + + A +AG G
Sbjct: 1219 IRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG------ 1270
Query: 812 ATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPK 871
++ IT +P+ P T ++TP + + + A+ + V W +S
Sbjct: 1271 NSSEIIT--VEPLAKAPA--RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDS--- 1323
Query: 872 NQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTW 931
L T+ R S ++ S+ +K +S + N S
Sbjct: 1324 ---NGTPSLVTIDGRRSIFSNG----------SFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
Query: 932 SMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIP 991
+ P P+ LTV + ++ +SW P I YIL Y+ D +
Sbjct: 1371 ILNLQV----QVPPDQPR-LTV--SKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNS-- 1421
Query: 992 IDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVE 1045
+ W IS ++++ +L T Y F + A+N G G +S+ I +TL E
Sbjct: 1422 -EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
Score = 174 bits (442), Expect = 4e-43
Identities = 244/1046 (23%), Positives = 398/1046 (38%), Gaps = 121/1046 (11%)
Query: 40 LRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLI 99
L+ P + G V L CS + W ++G L G + R +++ +L++
Sbjct: 314 LKATISPRKVKSSVGSQVSLSCSVTGTEDQE-LSWYRNGEILNPGKNVRITGINHENLIM 372
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
+++ K D G YQC D S V G + +S + V L
Sbjct: 373 DHMV-----KSDGGAYQCFVRK-DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL 426
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGA------LQISRLQPGDIGIYRCS 213
C V G P+PTI W + + G R+ + + L IS Q D G+YRC+
Sbjct: 427 MCNVKGTPLPTITWTLDDDPILK-GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
Query: 214 ARNPASSRTGNEAEVRILSDPGLHRQLYFLQRP-SNVVAIEGKDAVLECCVSGYPPPSFT 272
A N A +A + + + RP N+ AI G+D + C V GYP S
Sbjct: 486 ANNSAGVVL-YQARINVRGPASI--------RPMKNITAIAGRDTYIHCRVIGYPYYSIK 536
Query: 273 WLRGEEVIQLRSKKYSLLGGSNLLISNVTDD-DSGMYTC-VVTYKNENISASAELTVLVP 330
W + ++ ++ + L +S+V + D G YTC V+ + S S +TV VP
Sbjct: 537 WYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP 596
Query: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVP-TVNWMKNGDVVIPS---DYFQIVGGSNLR 386
P+ ++ + C V +P T+ W K+G + S I S+LR
Sbjct: 597 PFIQPFEFPRFSI-GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR 655
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446
I + G Y C+A NEA + +QLIV +P V+ PRD + + +
Sbjct: 656 ISNLSLMHNGNYTCIARNEAAAVEHQSQLIV---RVPPKFVV--QPRDQDGIYGKAVILN 710
Query: 447 LSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQ------LTVGNLKPEAMYTF 500
S A+G V+ +G + G +Q L + ++ E +
Sbjct: 711 CS------AEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYY 764
Query: 501 RVVAYNEWGPGESSQ-------PIKVATQPE--LQVPGPVENLQAVSTSPTSILITWEPP 551
N+ G S P + + P L G + + + I++ WE
Sbjct: 765 LCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE 824
Query: 552 AYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTD 611
P L T KE EV L +++ + + A N YG +
Sbjct: 825 DRIINPEMARYLVST-----KEVGEEVISTLQILPTVREDSGF-FSCHAINSYG-----E 873
Query: 612 DITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE- 670
D ++ L+ P + ++ V +R+I + W G N ITGY I + + +
Sbjct: 874 DRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDG--NSPITGYDIECKNKSDSWDS 931
Query: 671 ---METLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPD 727
+ + P + S YS ++ A G PSN T DE+
Sbjct: 932 AQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITA-----DEAAPDG 986
Query: 728 QPSSLHVRP-QTNCIIMSWTPPLN--PNIVVRGYIIGYGV----GSPYAETVRVDSK--Q 778
P +H+ P + I ++W P N ++RGY IGY G+ + VD+
Sbjct: 987 PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDS 1046
Query: 779 RYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838
Y+++ L + Y + ++A N AG G E TT L+D P+
Sbjct: 1047 EVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT--------------TLEDVPS--- 1089
Query: 839 DLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLY-TVRWRTSFSAS-AKYK 896
PP VQA+A + +++ +SW +++ K ++ + + W + K
Sbjct: 1090 ------YPPENVQAIATSPESISISW--STLSKEALNGILQGFRVIYWANLMDGELGEIK 1141
Query: 897 SEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITR 956
+ TT S GL+ T Y V+ S T E P P +
Sbjct: 1142 NITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAA 1200
Query: 957 EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDT 1016
V VSW PPL+ NG I Y +F + I ++ S D +++I +L+ +
Sbjct: 1201 SAS--MVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEF---EASPDSFSYRIPNLSRNR 1255
Query: 1017 MYYFRIQARNSKGVGPLSDPILFRTL 1042
Y + A S G G S+ I L
Sbjct: 1256 QYSVWVVAVTSAGRGNSSEIITVEPL 1281
Score = 102 bits (254), Expect = 3e-21
Identities = 102/429 (23%), Positives = 172/429 (40%), Gaps = 30/429 (6%)
Query: 112 EGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEV---IGEPM 168
+ Y C A SG I S+ + + + E G+ + KC + + +
Sbjct: 97 DNTYYCTAE-NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYI 155
Query: 169 PTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGD-IGIYRCSARNPASSRTGNEAE 227
+ W+K D + SR ++ +GAL I +Q D + YRC R+ + T
Sbjct: 156 TVVSWEK---DTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNS 212
Query: 228 VRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKY 287
R+ + L + A+ G+ L C G+P P + WL+ ++L +
Sbjct: 213 ARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQ 272
Query: 288 SLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMD 347
+ G LLI N+ DSG Y C V+ + L V P P + +
Sbjct: 273 KTVTG--LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQ 330
Query: 348 IEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVG--GSNLRILGVVKSDEGFYQCVAENE 405
+ C+V+G ++W +NG+++ P +I G NL + +VKSD G YQC +
Sbjct: 331 VSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD 390
Query: 406 AGNAQTSAQLIV----PK--PAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAE--AKG 457
+AQ Q+++ PK A V P+ P ++ + + ++W + KG
Sbjct: 391 KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG 450
Query: 458 NIQTFTVFFSREGDNRERALNTTQP-----GSLQLTVGNLKPEAMYTFRVVAYNEWGPGE 512
+ + EG N LN + G + T N +Y R+ N GP
Sbjct: 451 GSHRISQMITSEG-NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI---NVRGPA- 505
Query: 513 SSQPIKVAT 521
S +P+K T
Sbjct: 506 SIRPMKNIT 514
Score = 72.8 bits (177), Expect = 2e-12
Identities = 97/429 (22%), Positives = 173/429 (40%), Gaps = 31/429 (7%)
Query: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSR 443
+L + G+ K Q +A AG+ S Q+ + +P P V S+
Sbjct: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR-----TKEDVPGPPAGVKAAAASAS 1203
Query: 444 FVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVV 503
V +SW PP + G I+ +TVF S + P S + NL Y+ VV
Sbjct: 1204 MVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEAS-PDSFSYRIPNLSRNRQYSVWVV 1262
Query: 504 AYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRL 563
A G G SS+ I V +P + P + T+P I P A G
Sbjct: 1263 AVTSAGRGNSSEIITV--EPLAKAPARILTFSGTVTTPWMKDIVL--PCKAVGDPSPAVK 1318
Query: 564 FCTEVSTGKEQNIEVDGL-------SYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVV 616
+ + S G + +DG S+ + +K +A N +G +D+I +
Sbjct: 1319 WMKD-SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG----SDEIILN 1373
Query: 617 TLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRK-TTRRGEMETLE 675
VP P+ +++ S SI +SWLP +G + I GY +++ + + + +
Sbjct: 1374 LQVQVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSS--IRGYILQYSEDNSEQWGSFPIS 1430
Query: 676 PNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVR 735
P+ Y L+ G+ Y F ++A G G S A+T + S+ + +S++
Sbjct: 1431 PSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT- 1489
Query: 736 PQTNCIIMSWTPPLNPNIVVRGYIIGY-GVGSPYAETVRVDSKQRYYSIERLESSSHYVI 794
+ ++ W P + + + Y G+ T + S + Y + L+ ++ Y +
Sbjct: 1490 TRVRLNLIGWNDGGCP---ITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYEL 1546
Query: 795 SLKAFNNAG 803
++ N+AG
Sbjct: 1547 QMRVCNSAG 1555
Score = 68.6 bits (166), Expect = 4e-11
Identities = 74/269 (27%), Positives = 106/269 (39%), Gaps = 25/269 (9%)
Query: 347 DIEFECTVSGKPVPTVNWMKNGD----VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVA 402
DI C G P P V WMK+ + +V I + I V D G+Y C+A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
Query: 403 ENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTF 462
N G+ + L V P P PR V SS + LSW P +I+ +
Sbjct: 1362 NNNWGSDEIILNLQVQVP--------PDQPRLTVSKTTSSS-ITLSWLPGDNGGSSIRGY 1412
Query: 463 TVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT- 521
+ +S E ++ + P + NLK Y F + A N GPG S+ I+ T
Sbjct: 1413 ILQYS-EDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTL 1471
Query: 522 QPELQVPGPVENLQAVSTSPTSI-LITWEPPAYANGPVQG----YRLFCTEVSTGKEQNI 576
E Q E +++T+ + LI W P+ YR F T V T ++
Sbjct: 1472 GKEPQFSKEQELFASINTTRVRLNLIGWND---GGCPITSFTLEYRPFGTTVWTTAQRTS 1528
Query: 577 EVDGLSYKLEGLKKFTEYSLRFLAYNRYG 605
SY L L++ T Y L+ N G
Sbjct: 1529 L--SKSYILYDLQEATWYELQMRVCNSAG 1555
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 268 bits (684), Expect = 4e-71
Identities = 297/1063 (27%), Positives = 443/1063 (41%), Gaps = 127/1063 (11%)
Query: 36 AFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ--QLS 93
A T RF P D + GG C A D P I W K G ++ ++R + +
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPR-PKIVWNKKGKKVS---NQRFEVIEFD 75
Query: 94 NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF- 152
+GS + I R + DE +Y+C AS + +++V+ L L + + F
Sbjct: 76 DGSGSVLRIQPLRTPR-DEAIYECVAS--------NNVGEISVSTRLTVLREDQIPRGFP 126
Query: 153 ---MGD---------TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPS------ 194
MG T + C G P P I W K+ + + R+ L S
Sbjct: 127 TIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT 186
Query: 195 ---GALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHR-QLYFLQRPSNVV 250
GALQI + + D G Y C A N A +R A + + + R F P+N
Sbjct: 187 PIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHE 246
Query: 251 AIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTC 310
+ G + C G P P W+ G E L + +G + L +++V S YTC
Sbjct: 247 IMPGGSVNITCVAVGSPMPYVKWMLGAE--DLTPEDDMPIGRNVLELNDVRQ--SANYTC 302
Query: 311 VVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWM---- 365
V I A A++TV P P ES T SG P P ++
Sbjct: 303 VAMSTLGVIEAIAQITVKALP---KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 359
Query: 366 -KNGDVVIPSDYFQIVGGSNLR--ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAI 422
KN + + Y +I G + R + G+ + ++ VA N G S ++
Sbjct: 360 PKNSEEL----YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT--- 412
Query: 423 PSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQP 482
S SAPRDV ++SS + + W+ P E G IQ + V+++ +
Sbjct: 413 -SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNV 471
Query: 483 GSLQLT-VGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSP 541
Q+T +GNL P+ Y+ +V+A+ G G S I+V TQ VPG N +A S
Sbjct: 472 ADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG--VPGQPLNFKAEPESE 529
Query: 542 TSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVD-GLSYKLEGLKKFTEYSLRFLA 600
TSIL++W PP + + Y L + G+EQ I ++ G SY+L+GLK + Y R A
Sbjct: 530 TSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 601 YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660
+ G G ST +I+ T+ PSAPPQ++S +S SI VSW PPP QNG IT Y I
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSI 647
Query: 661 RHR----KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP 716
++ + + E+ + + YL LEK ++Y V+A T G GP S T
Sbjct: 648 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 717 ENDLDESQVPD-QPSSLHVRP-QTNCIIMSWTPPLNPNI---VVRGYIIGY-------GV 764
E+ VP P + V + + +SW P+ PN +RGY + Y
Sbjct: 708 ED------VPSGPPRKVEVEAVNSTSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPK 760
Query: 765 GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPV 824
G P + V + Q I L+ + Y +++ A+ G+G + + + T V
Sbjct: 761 GQPMLKDVMLADAQDMI-ISGLQPETSYSLTVTAYTTKGDG-----ARSKPKLVSTTGAV 814
Query: 825 DYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
P L T + PPV D P + +
Sbjct: 815 PGKPRLVINHTQMNTALIQWHPPV-----------------DTFGPLQGYRLKFGRKDME 857
Query: 885 WRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
T+ S K ED +TAT + Y F + +N+ M + E P
Sbjct: 858 PLTTLEFSEK---ED----HFTATDIHKGASYVFR-LSARNKVGFGEEMVKEISIPEEVP 909
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPL--EANGKITAYILFYTLDKNIPIDDWIMETISG 1002
T P++L + +V +SWQPP+ E NG IT Y L Y D NIP+ +
Sbjct: 910 TGFPQNLH--SEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINIPLLPMEQLIVPA 966
Query: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVE 1045
D T + L DT Y +++A SKG GP S + FRTL V+
Sbjct: 967 D-TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1008
Score = 150 bits (380), Expect = 7e-36
Identities = 211/909 (23%), Positives = 341/909 (37%), Gaps = 137/909 (15%)
Query: 242 FLQRPSNVVAIEGKDAVLECCVSGYPPPSFTW-LRGEEVIQLRSKKYSLLGGSNLLISNV 300
F + P + + G A C +G P P W +G++V R + GS ++
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 301 ---TDDDSGMYTCVVTYKNENISASAELTVL----VPPWFLN---HPSNLYAYESMDIEF 350
T D +Y CV + IS S LTVL +P F P +
Sbjct: 86 PLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATM 145
Query: 351 ECTVSGKPVPTVNWMK--------NGDVVIPSDYFQIVGGSNLR----ILGVVKSDEGFY 398
C SG P P + W K N + I + +GG+ +R I +SD+G Y
Sbjct: 146 LCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKY 205
Query: 399 QCVAENEAGNAQTS-----------AQLIVPKPAIPSSS--VLPSAPRDVVPVLVSSRFV 445
+CVA N AG ++ + + P+ +IP ++ ++P ++ V V S
Sbjct: 206 ECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMP 265
Query: 446 RLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAY 505
+ W AE + E D G L + +++ A YT VA
Sbjct: 266 YVKWMLGAED----------LTPEDD--------MPIGRNVLELNDVRQSANYT--CVAM 305
Query: 506 NEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFC 565
+ G E+ I V P+ P ++ TSI +TW+ N Y +
Sbjct: 306 STLGVIEAIAQITVKALPK-----PPGTPVVTESTATSITLTWDS---GNPEPVSYYIIQ 357
Query: 566 TEVSTGKEQNIEVDGLS---YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVP 622
+ +E E+DG++ Y + GL +++Y R +A N G G ++ + T P
Sbjct: 358 HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 417
Query: 623 SAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL 682
S+ P++V +++S +I V W P NG I GY++ + + ++ N
Sbjct: 418 SSAPRDVQARMLSSTTILVQWKEPEE--PNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 683 FT---GLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTN 739
T L YS +V A T G GP S+ T ++ VP QP + P++
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVIT------QTGVPGQPLNFKAEPESE 529
Query: 740 C-IIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKA 798
I++SWTPP + I Y + Y G E Y ++ L+ +S Y L A
Sbjct: 530 TSILLSWTPPRSDTIA--NYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 799 FNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHD 858
+ G G A+T I+ T S P PP + + +
Sbjct: 588 RSPQGLG------ASTAEISARTMQ-----------------SKPSAPPQDISCTSPSST 624
Query: 859 AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKS-----EDTTSLSYTATGLKPN 913
++ VSW V K + + Y++++ K DTT Y L+
Sbjct: 625 SILVSWQPPPVEK--QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTK--YLLEQLEKW 680
Query: 914 TMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPL-- 971
T Y +V + S++ T E P+ P+ + V +V VSW+ P+
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV--EAVNSTSVKVSWRSPVPN 738
Query: 972 EANGKITAYILFYTLDKNIPI--DDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKG 1029
+ +G+I Y + Y +N + + + D I L +T Y + A +KG
Sbjct: 739 KQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKG 798
Query: 1030 VGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGS 1089
G S P L T G P L+ T + Q HPP +
Sbjct: 799 DGARSKPKLVSTT------------------GAVPGKPRLVINHTQMNTALIQWHPPVDT 840
Query: 1090 VTPQKNSNL 1098
P + L
Sbjct: 841 FGPLQGYRL 849
Score = 107 bits (267), Expect = 8e-23
Identities = 112/406 (27%), Positives = 167/406 (41%), Gaps = 28/406 (6%)
Query: 422 IPSSSVLPSAP-RDVVPVLVSSRFVRLSWRPPAEAK--GNIQTFTVFFSR----EGDNRE 474
I ++ +PS P R V V+S V++SWR P K G I+ + V + R E +
Sbjct: 704 IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQP 763
Query: 475 RALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENL 534
+ + + + L+PE Y+ V AY G G S+P V+T VPG L
Sbjct: 764 MLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA--VPGK-PRL 820
Query: 535 QAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLS--YKLEGLKKFT 592
T + LI W PP GP+QGYRL +E + + K
Sbjct: 821 VINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGA 880
Query: 593 EYSLRFLAYNRYGPGVS-TDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQ 651
Y R A N+ G G +I++ +VP+ PQN+ E S S+++SW PP +
Sbjct: 881 SYVFRLSARNKVGFGEEMVKEISIP--EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 938
Query: 652 NGFITGYKIRHR--KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSN 709
NG IT Y + +R + + P + TGL+ + Y +V A T G GP
Sbjct: 939 NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP--- 995
Query: 710 WYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPY 768
Y+ L QV + HV+ +++SW P N N + I+ Y G
Sbjct: 996 -YSPSVQFRTLPVDQV--FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKIL-YDDGKMV 1051
Query: 769 AETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATT 814
E VD + I L+ Y L N+ G+ +A T
Sbjct: 1052 EE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1094
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 266 bits (681), Expect = 8e-71
Identities = 297/1071 (27%), Positives = 445/1071 (41%), Gaps = 134/1071 (12%)
Query: 36 AFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ--QLS 93
A T RF P D + GG C A D P I W K G ++ ++R + +
Sbjct: 20 AETPPRFTRTPVDQTGVSGGVASFICQATGDPR-PKIVWNKKGKKVS---NQRFEVIEFD 75
Query: 94 NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF- 152
+GS + I R + DE +Y+C AS + +++V+ L L + + F
Sbjct: 76 DGSGSVLRIQPLRTPR-DEAIYECVAS--------NNVGEISVSTRLTVLREDQIPRGFP 126
Query: 153 ---MGD---------TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPS------ 194
MG T + C G P P I W K+ + + R+ L S
Sbjct: 127 TIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT 186
Query: 195 ---GALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHR-QLYFLQRPSNVV 250
GALQI + + D G Y C A N A +R A + + + R F P+N
Sbjct: 187 PIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHE 246
Query: 251 AIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTC 310
+ G + C G P P W+ G E L + +G + L +++V S YTC
Sbjct: 247 IMPGGSVNITCVAVGSPMPYVKWMLGAE--DLTPEDDMPIGRNVLELNDVRQ--SANYTC 302
Query: 311 VVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWM---- 365
V I A A++TV P P ES T SG P P ++
Sbjct: 303 VAMSTLGVIEAIAQITVKALP---KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHK 359
Query: 366 -KNGDVVIPSDYFQIVGGSNLR--ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAI 422
KN + + Y +I G + R + G+ + ++ VA N G S ++
Sbjct: 360 PKNSEEL----YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT--- 412
Query: 423 PSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQP 482
S SAPRDV ++SS + + W+ P E G IQ + V+++ +
Sbjct: 413 -SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNV 471
Query: 483 GSLQLT-VGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSP 541
Q+T +GNL P+ Y+ +V+A+ G G S I+V TQ VPG N +A S
Sbjct: 472 ADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG--VPGQPLNFKAEPESE 529
Query: 542 TSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVD-GLSYKLEGLKKFTEYSLRFLA 600
TSIL++W PP + + Y L + G+EQ I ++ G SY+L+GLK + Y R A
Sbjct: 530 TSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 601 YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660
+ G G ST +I+ T+ PSAPPQ++S +S SI VSW PPP QNG IT Y I
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSI 647
Query: 661 RHR----KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP 716
++ + + E+ + + YL LEK ++Y V+A T G GP S T
Sbjct: 648 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 717 ENDLDESQVPD-QPSSLHVRP-QTNCIIMSWTPPLNPNI---VVRGYIIGY-------GV 764
E+ VP P + V + + +SW P+ PN +RGY + Y
Sbjct: 708 ED------VPSGPPRKVEVEAVNSTSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPK 760
Query: 765 GSPYAETVRV--------DSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRS 816
G P + V + D+ + I L+ + Y +++ A+ G+G + +
Sbjct: 761 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDG-----ARSKPK 815
Query: 817 ITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTS 876
+ T V P L T + PPV D P
Sbjct: 816 LVSTTGAVPGKPRLVINHTQMNTALIQWHPPV-----------------DTFGPLQGYRL 858
Query: 877 EVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAH 936
+ + T+ S K ED +TAT + Y F + +N+ M
Sbjct: 859 KFGRKDMEPLTTLEFSEK---ED----HFTATDIHKGASYVFR-LSARNKVGFGEEMVKE 910
Query: 937 ATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPL--EANGKITAYILFYTLDKNIPIDD 994
+ E PT P++L + +V +SWQPP+ E NG IT Y L Y D NIP+
Sbjct: 911 ISIPEEVPTGFPQNLH--SEGTTSTSVQLSWQPPVLAERNGIITKYTLLYR-DINIPLLP 967
Query: 995 WIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVE 1045
+ D T + L DT Y +++A SKG GP S + FRTL V+
Sbjct: 968 MEQLIVPAD-TTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1017
Score = 148 bits (373), Expect = 4e-35
Identities = 212/918 (23%), Positives = 344/918 (37%), Gaps = 146/918 (15%)
Query: 242 FLQRPSNVVAIEGKDAVLECCVSGYPPPSFTW-LRGEEVIQLRSKKYSLLGGSNLLISNV 300
F + P + + G A C +G P P W +G++V R + GS ++
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 301 ---TDDDSGMYTCVVTYKNENISASAELTVL----VPPWFLN---HPSNLYAYESMDIEF 350
T D +Y CV + IS S LTVL +P F P +
Sbjct: 86 PLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATM 145
Query: 351 ECTVSGKPVPTVNWMK--------NGDVVIPSDYFQIVGGSNLR----ILGVVKSDEGFY 398
C SG P P + W K N + I + +GG+ +R I +SD+G Y
Sbjct: 146 LCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKY 205
Query: 399 QCVAENEAGNAQTS-----------AQLIVPKPAIPSSS--VLPSAPRDVVPVLVSSRFV 445
+CVA N AG ++ + + P+ +IP ++ ++P ++ V V S
Sbjct: 206 ECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMP 265
Query: 446 RLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAY 505
+ W AE + E D G L + +++ A YT VA
Sbjct: 266 YVKWMLGAED----------LTPEDD--------MPIGRNVLELNDVRQSANYT--CVAM 305
Query: 506 NEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFC 565
+ G E+ I V P+ P ++ TSI +TW+ N Y +
Sbjct: 306 STLGVIEAIAQITVKALPK-----PPGTPVVTESTATSITLTWDS---GNPEPVSYYIIQ 357
Query: 566 TEVSTGKEQNIEVDGLS---YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVP 622
+ +E E+DG++ Y + GL +++Y R +A N G G ++ + T P
Sbjct: 358 HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 417
Query: 623 SAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL 682
S+ P++V +++S +I V W P NG I GY++ + + ++ N
Sbjct: 418 SSAPRDVQARMLSSTTILVQWKEPEE--PNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 683 FT---GLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTN 739
T L YS +V A T G GP S+ T ++ VP QP + P++
Sbjct: 476 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVIT------QTGVPGQPLNFKAEPESE 529
Query: 740 C-IIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKA 798
I++SWTPP + I Y + Y G E Y ++ L+ +S Y L A
Sbjct: 530 TSILLSWTPPRSDTIA--NYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 799 FNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHD 858
+ G G A+T I+ T S P PP + + +
Sbjct: 588 RSPQGLG------ASTAEISARTMQ-----------------SKPSAPPQDISCTSPSST 624
Query: 859 AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKS-----EDTTSLSYTATGLKPN 913
++ VSW V K + + Y++++ K DTT Y L+
Sbjct: 625 SILVSWQPPPVEK--QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTK--YLLEQLEKW 680
Query: 914 TMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPL-- 971
T Y +V + S++ T E P+ P+ + V +V VSW+ P+
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEV--EAVNSTSVKVSWRSPVPN 738
Query: 972 EANGKITAYILFYT-LDKNIPIDDWIMETIS--------GDRLTHQ--IMDLNLDTMYYF 1020
+ +G+I Y + Y ++ P +++ + D H I L +T Y
Sbjct: 739 KQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSL 798
Query: 1021 RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI 1080
+ A +KG G S P L T G P L+ T +
Sbjct: 799 TVTAYTTKGDGARSKPKLVSTT------------------GAVPGKPRLVINHTQMNTAL 840
Query: 1081 GQMHPPHGSVTPQKNSNL 1098
Q HPP + P + L
Sbjct: 841 IQWHPPVDTFGPLQGYRL 858
Score = 103 bits (257), Expect = 1e-21
Identities = 112/415 (26%), Positives = 167/415 (40%), Gaps = 37/415 (8%)
Query: 422 IPSSSVLPSAP-RDVVPVLVSSRFVRLSWRPPAEAK--GNIQTFTVFFSREGDNRERALN 478
I ++ +PS P R V V+S V++SWR P K G I+ + V + R + +
Sbjct: 704 IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQP 763
Query: 479 TTQPGSL-------------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPEL 525
+ L + + L+PE Y+ V AY G G S+P V+T
Sbjct: 764 MLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA- 822
Query: 526 QVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLS--Y 583
VPG L T + LI W PP GP+QGYRL +E +
Sbjct: 823 -VPGK-PRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHF 880
Query: 584 KLEGLKKFTEYSLRFLAYNRYGPGVS-TDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVS 642
+ K Y R A N+ G G +I++ +VP+ PQN+ E S S+++S
Sbjct: 881 TATDIHKGASYVFRLSARNKVGFGEEMVKEISIP--EEVPTGFPQNLHSEGTTSTSVQLS 938
Query: 643 WLPPPSGTQNGFITGYKIRHR--KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMT 700
W PP +NG IT Y + +R + + P + TGL+ + Y +V A T
Sbjct: 939 WQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 998
Query: 701 VNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRGYI 759
G GP Y+ L QV + HV+ +++SW P N N + I
Sbjct: 999 SKGPGP----YSPSVQFRTLPVDQV--FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKI 1052
Query: 760 IGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATT 814
+ Y G E VD + I L+ Y L N+ G+ +A T
Sbjct: 1053 L-YDDGKMVEE---VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 1103
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 265 bits (678), Expect = 2e-70
Identities = 276/1014 (27%), Positives = 422/1014 (41%), Gaps = 113/1014 (11%)
Query: 72 IKWKKDGIHLALGMDE--RKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIIS 129
+ WK++G+ + G+ R+ +SN + D G Y CEA+L S +
Sbjct: 327 VTWKRNGVRITSGLHSFGRRLTISNPT------------SADTGPYVCEAALPGSAFEPA 374
Query: 130 R-TAKVAVAGPLRFLSQTES-VTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDS 187
R TA + + P F ++ ES ++A + +TV + C+ +G P+PT+ W K+ ++ + +
Sbjct: 375 RATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQ-NP 433
Query: 188 RVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPS 247
R VL SG L+I +L+P D GI++C A N G E + D + F QRP
Sbjct: 434 RYKVLASGGLRIQKLRPEDSGIFQCFASNE-----GGEIQTHTYLDV-TNIAPVFTQRPV 487
Query: 248 NVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI---QLRSKKYSLLGGSNLLISNVTDDD 304
+ +G A+L C VSG P P+ TW R ++ +R ++ LL L I+ V D
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
Query: 305 SGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVN- 363
+G YTC +++ASA LTV ++ P + + C + P ++
Sbjct: 548 AGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRY 607
Query: 364 -WMKNGDVVIPSDYFQIV--GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
W K+ + PS +IV +L I D G Y C +E GN A+L V +
Sbjct: 608 VWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE- 666
Query: 421 AIPSSSVLPSAPRDVV--PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN 478
LP +P++++ P S V LSW P + I + V S + L+
Sbjct: 667 -------LPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLS 719
Query: 479 TTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVS 538
P +TV L P Y FRV A NE G G+ S PE P +N+ A
Sbjct: 720 NVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASG 779
Query: 539 TSPTSILITWEPPAYA--NGPVQGYRL---FCTEVSTGKEQNIEVDGLSYKL-EGLKKFT 592
+ SI++ W+PP NG ++GY L +++NI ++Y L L +T
Sbjct: 780 RTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWT 839
Query: 593 EYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQN 652
+Y ++ AYN G GV + +T TL VP+APPQNV E VNS +I+ W PPP N
Sbjct: 840 QYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFIN 899
Query: 653 GFITGYKIR--HRKTTRRGEMETLEPNNLWY---LFTGLEKGSQYSFQVSAMTVNGTGPP 707
G GYK+ + T+ P+ T L+K + Y V T G GPP
Sbjct: 900 GINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPP 959
Query: 708 SNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII-MSWTPPLNPNIVVRGYIIGYGV-- 764
S TP+ + P L + + +SW PL N ++ GY I + V
Sbjct: 960 S------TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYG 1013
Query: 765 GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPV 824
+ T ++S Y I+ L S + Y I + A G G L S+T S P
Sbjct: 1014 RNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTG--LVTSSTISSGVPP---- 1067
Query: 825 DYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
D P + +L + P R + + KTS R
Sbjct: 1068 -------DLPGAPSNLVISNISP-------------RSATLQFRPGYDGKTS-----ISR 1102
Query: 885 WRTSFSASAKYKSEDTTSL----------SYTATGLKPNTMYEFSVMVTKNRRSSTWSMT 934
W A E+ +L L P T Y F + S +S +
Sbjct: 1103 WIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPS 1162
Query: 935 AHA-TTYEAAPTSAPKDLTVITREGKPRAVIVSWQP----PLEANGKITAYILFYTLDKN 989
+ T +A P AP +TV R ++ + W P N + Y + Y
Sbjct: 1163 SRVIQTLQAPPDVAPTSVTV--RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYW---R 1217
Query: 990 IPIDDWIMETISGDRLTHQ--IMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
+ + + DRL + I +L Y ++QA N+ G GP S+ + RT
Sbjct: 1218 SDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRT 1271
Score = 192 bits (487), Expect = 3e-48
Identities = 263/1098 (23%), Positives = 434/1098 (39%), Gaps = 146/1098 (13%)
Query: 19 GASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRG-------VPV 71
G + A L + F+ TA F+ EP + + D G +P
Sbjct: 358 GPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPT 417
Query: 72 IKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRT 131
++W KD I ++ + R + L++G L IQ + D G++QC AS + G I + T
Sbjct: 418 LQWYKDAISISRLQNPRYKVLASGGLRIQKL-----RPEDSGIFQCFAS-NEGGEIQTHT 471
Query: 132 -AKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTP----IPGD 186
V P+ F + T G T +L+CEV G P P I W++ L IP
Sbjct: 472 YLDVTNIAPV-FTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIP-- 528
Query: 187 SRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRP 246
R ++L SG LQI+ + D G Y C A N E + + + + + P
Sbjct: 529 -RFMLLESGGLQIAPVFIQDAGNYTCYAAN-------TEGSLNASATLTVWNRTSIVHPP 580
Query: 247 SNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLL---GGSNLLISNVTDD 303
+ V I+G A L C + P S ++ ++ + L S + +LLIS
Sbjct: 581 EDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSG 640
Query: 304 DSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVN 363
D G Y+C + + N S A L V+ P + P NL + S ++
Sbjct: 641 DIGDYSCEIVSEGGNDSRMARLEVIELP---HSPQNLLVSPNS--------SHSHAVVLS 689
Query: 364 WMKNGDVVIPSDYFQIVGGSN-----------------LRILGVVKSDEGFYQCVAENEA 406
W++ D P Y+ + N + + G+ + ++ A NE
Sbjct: 690 WVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEV 749
Query: 407 GNAQTSAQ---LIVPKPAIPSSSVLPSA-PRDVVPVLVSSRFVRLSWRPPAEAKGN--IQ 460
G Q SA+ L++P+ PSA P+++V +++ + + W+PP E + N ++
Sbjct: 750 GRGQYSAETSRLMLPEEP-------PSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLR 802
Query: 461 TFTVFFSREG-DNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKV 519
+ + + G + N T P V +L Y +V AYN G G S+ +
Sbjct: 803 GYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAV-- 860
Query: 520 ATQPELQ-VP-GPVENLQAVSTSPTSILITWEPP--AYANGPVQGYRLFCTEVSTGKEQN 575
T+ LQ VP P +N+Q + + T+I W PP + NG QGY+L +
Sbjct: 861 -TEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVT 919
Query: 576 I-----EVDGLSY-KLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
+ + G+ + + LKKFT Y L + G G + V T D P A
Sbjct: 920 VVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLS 979
Query: 630 SLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE--METLEPNNLWYLFTGLE 687
E++++ S+KVSW P +NG ITGY+I R TL Y GL
Sbjct: 980 FTEILDT-SLKVSWQEPLE--KNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLS 1036
Query: 688 KGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSL---HVRPQTNCIIMS 744
+ Y+ V+A+T GTG ++ + DL P PS+L ++ P++ +
Sbjct: 1037 SLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDL-----PGAPSNLVISNISPRS--ATLQ 1089
Query: 745 WTPPLNPNIVVRGYIIGYGVG---------SPYAETVRVDSKQRYYSIERLESSSHYVIS 795
+ P + + +I+ VG + Y E D++ I L +HY
Sbjct: 1090 FRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQM--LEIPNLTPYTHYRFR 1147
Query: 796 LKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL 855
+K N G P S ++R I P P + P V
Sbjct: 1148 MKQVNIVG---PSPYSPSSRVIQTLQAP-------------------PDVAPTSVTVRTA 1185
Query: 856 THDAVRVSWADNSVPKNQKTSEVRLYTVR-WRTSFSASAKYK-SEDTTSLSYTATGLKPN 913
+ ++R+ W + E Y ++ WR+ +SA + D +T L+
Sbjct: 1186 SETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEW 1245
Query: 914 TMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQ--PPL 971
YE + + WS T E+ P++AP++ V ++++W P
Sbjct: 1246 MEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPEN--VSAEAVSSTQILLTWTSVPEQ 1303
Query: 972 EANGKITAY-ILFYTLDKNIPIDDWIMETISGDRLTHQIM-DLNLDTMYYFRIQARNSKG 1029
+ NG I Y ILF D + I + G+ ++ L +Y ++ A G
Sbjct: 1304 DQNGLILGYKILFRAKDLDPEPRSHI---VRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
Query: 1030 VGPLSDPILFRTLKVEHP 1047
G S P++ K + P
Sbjct: 1361 NGVPSTPLILERTKDDAP 1378
Score = 156 bits (394), Expect = 2e-37
Identities = 180/668 (26%), Positives = 279/668 (41%), Gaps = 84/668 (12%)
Query: 362 VNWM----KNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFY--QCVAENEAGNAQTSAQL 415
V+W KNG + +++ G ++ R+ + S Y Q ++ +A
Sbjct: 990 VSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVT 1049
Query: 416 IVPKPAIPSSSV-------LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF--F 466
V + SS++ LP AP ++V +S R L +RP + K +I + V
Sbjct: 1050 AVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQV 1109
Query: 467 SREGDNRERAL---NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQP 523
GD E +P + L + NL P Y FR+ N GP S +V
Sbjct: 1110 GAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQT- 1168
Query: 524 ELQVPGPVE--NLQAVSTSPTSILITWEP---PAYANGPVQ-GYRL--FCTEVSTGKEQN 575
LQ P V ++ + S TS+ + W P Y P GYR+ + +++ +
Sbjct: 1169 -LQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQ 1227
Query: 576 IEVDGLS--YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV 633
+ D L + +E L+++ EY L+ A+N G G ++ + T VPSA P+NVS E
Sbjct: 1228 VVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEA 1287
Query: 634 VNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET--LEPNNLW-YLFTGLEKGS 690
V+S I ++W P QNG I GYKI R E + + N+ L GL K
Sbjct: 1288 VSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFV 1347
Query: 691 QYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT--NCIIMSWTPP 748
Y QV A T G G PS E ++D P P L V P+ + + W PP
Sbjct: 1348 LYELQVLAFTRIGNGVPSTPLILERTKDD-----APGPPVRL-VFPEVRLTSVRIVWQPP 1401
Query: 749 LNPNIVVRGYIIGYGV--GSPYA-ETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEG 805
PN ++ GY I Y + SP+ TV V + R ++ L S Y+ L A G G
Sbjct: 1402 EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461
Query: 806 VPLYESA-TTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSW 864
PL + TT P P + ++P V A +L R+ W
Sbjct: 1462 EPLEATVITTEKRERPAPPREL-----------------LVPQAEVTARSL-----RLQW 1499
Query: 865 ADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATG-----LKPNTMYEFS 919
VP + S +R +T++ R + S +S+S+ AT L+P T Y+
Sbjct: 1500 ----VPGSDGASPIRYFTMQVRELPRGEWQTYS---SSISHEATACVVDRLRPFTSYKLR 1552
Query: 920 VMVTKNRRSSTWSMTAHA-TTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLE--ANGK 976
+ T + S +S A TT + P P ++ +V++ WQPP + NG
Sbjct: 1553 LKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPH--TTSSVLIQWQPPRDESLNGL 1610
Query: 977 ITAYILFY 984
+ Y ++Y
Sbjct: 1611 LQGYRIYY 1618
Score = 135 bits (339), Expect = 4e-31
Identities = 241/1071 (22%), Positives = 392/1071 (36%), Gaps = 140/1071 (13%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDE--RKQQLSNGSLLI 99
F P D G +L C S P I WK++ LA G R L +G L I
Sbjct: 482 FTQRPVDTTVTDGMTAILRCEV-SGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQI 540
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
+ D G Y C A+ ++ ++ +A + V + E G T L
Sbjct: 541 APVFIQ-----DAGNYTCYAA--NTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATL 593
Query: 160 KCEVIGEPMPTIH--WQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNP 217
C +P ++ W+K+ LTP SR+VV G+L IS+ GDIG Y C
Sbjct: 594 HCGATHDPRVSLRYVWKKDNVALTP-SSTSRIVVEKDGSLLISQTWSGDIGDYSCEI--- 649
Query: 218 ASSRTGNE---AEVRILSDPGLHRQLYFLQRPSNVVAI--------EGKDAVL----ECC 262
S GN+ A + ++ P + L S+ A+ +G +L E
Sbjct: 650 -VSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELS 708
Query: 263 VSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTY-------- 314
+ P G E+ + + + V + G Y+ +
Sbjct: 709 ENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPP 768
Query: 315 ----KNENISASAELTVLV---PPWFLNHPSNLYAY----ESMDIEFECTVSGKPVPTVN 363
KN S +++V PP H L Y + E P VN
Sbjct: 769 SAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVN 828
Query: 364 WMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP 423
+ D++I + Y V N LGV F + V E T+ V A+
Sbjct: 829 YCLVTDLIIWTQYEIQVAAYNGAGLGV------FSRAVTEYTLQGVPTAPPQNVQTEAVN 882
Query: 424 SSSV--LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQ 481
S+++ L + P ++ + L+W PA+A + T+ G +
Sbjct: 883 STTIQFLWNPPPQQFINGINQGYKLLAW--PADAPEAVTVVTIAPDFHGVHHGH------ 934
Query: 482 PGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSP 541
+ NLK Y V+ + G G S P V TQ + PG V +L
Sbjct: 935 -------ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDK--PGAVGHLSFTEILD 985
Query: 542 TSILITWEPPAYANGPVQGYRLFCTEVSTGKEQ---NIEVDGLSYKLEGLKKFTEYSLRF 598
TS+ ++W+ P NG + GY++ + + YK++GL T Y++
Sbjct: 986 TSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDV 1045
Query: 599 LAYNRYGPG-VSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITG 657
A G G V++ I+ D+P AP N+ + ++ RS + + P G + I+
Sbjct: 1046 AAVTAVGTGLVTSSTISSGVPPDLPGAP-SNLVISNISPRSATLQFRPGYDGKTS--ISR 1102
Query: 658 YKIRHRKTTRRGEMETL-------EPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNW 710
+ + + E E + EP+ L + Y F++ + + G P S
Sbjct: 1103 WIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYS-- 1160
Query: 711 YTAETPENDLDES-QVPDQ--PSSLHVRPQTNCII-MSWTP----PLNPNIVVRGYIIGY 762
P + + ++ Q P P+S+ VR + + + W P N N GY I Y
Sbjct: 1161 -----PSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKY 1215
Query: 763 ---GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITD 819
+ S V D +R ++IE LE Y + ++AFN G G P E R+
Sbjct: 1216 WRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVRGRTRE- 1273
Query: 820 PTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVR 879
S P P V A A++ + ++W SVP+ + +
Sbjct: 1274 ---------------------SVPSAAPENVSAEAVSSTQILLTWT--SVPEQDQNGLIL 1310
Query: 880 LYTVRWRTSF--SASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA 937
Y + +R + + S GL+ +YE V+ + S
Sbjct: 1311 GYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPL-- 1368
Query: 938 TTYEAAPTSAP-KDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWI 996
E AP + ++ E + +V + WQPP E NG I Y + Y L + P
Sbjct: 1369 -ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTT 1427
Query: 997 METISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHP 1047
+E + DL ++ Y FR+ A+ +G G + + T K E P
Sbjct: 1428 VE-VGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERP 1477
Score = 130 bits (328), Expect = 7e-30
Identities = 169/681 (24%), Positives = 265/681 (38%), Gaps = 90/681 (13%)
Query: 415 LIVPKPAIPSSSVLPS--APRDVVPVLVSSRF-----VRLSWRPPAEAKGNIQTFTVFFS 467
++ P P PSS V+ + AP DV P V+ R +RL W P +++ N +V +
Sbjct: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYR 1212
Query: 468 RE---GDNRERALNTTQPGSLQ--LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ 522
+ D + A+ L+ T+ L+ Y ++ A+N G G S+ ++ T+
Sbjct: 1213 IKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTR 1272
Query: 523 PELQVPGPVENLQAVSTSPTSILITWE--PPAYANGPVQGYRLFCTEVSTGKEQNIEV-- 578
+ P EN+ A + S T IL+TW P NG + GY++ E +
Sbjct: 1273 ESVPSAAP-ENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR 1331
Query: 579 --DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNS 636
S L GL+KF Y L+ LA+ R G GV + + + D PP + V
Sbjct: 1332 GNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRL 1391
Query: 637 RSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE-METLEPNNLWYLFTG--LEKGSQYS 693
S+++ W PP NG I GY+I +R + T+E FT L S Y
Sbjct: 1392 TSVRIVWQPPEE--PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYI 1449
Query: 694 FQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMS----WTPPL 749
F++SA T G G P T ++ + P P L V PQ S W P
Sbjct: 1450 FRLSAKTRQGWGEPLEATVITT-----EKRERPAPPRELLV-PQAEVTARSLRLQWVPGS 1503
Query: 750 NPNIVVRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGE 804
+ +R + + G Y+ ++ ++ ++RL + Y + LKA N+ G+
Sbjct: 1504 DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACV--VDRLRPFTSYKLRLKATNDIGD 1561
Query: 805 GVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSW 864
S+ T ++T D P PP V A T +V + W
Sbjct: 1562 SD---FSSETEAVTTLQD-------------------VPGEPPGSVSATPHTTSSVLIQW 1599
Query: 865 A---DNSVPKNQKTSEVRLY-------------------TVRWRTSFSASAKYKSEDTTS 902
D S+ N R+Y + +A + +K+ +++S
Sbjct: 1600 QPPRDESL--NGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSS 1657
Query: 903 LSYTA--TGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP 960
S T LK YE + S S EAAP AP+++ V
Sbjct: 1658 TSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQ 1717
Query: 961 RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF 1020
V PP NG I Y ++Y + + + M+ + ++ +L T Y
Sbjct: 1718 LEVTWDPPPPESQNGNIQGYKIYY-WEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLV 1776
Query: 1021 RIQARNSKGVGPLSDPILFRT 1041
I A N+ G GP SDP RT
Sbjct: 1777 SISAFNAAGDGPKSDPQQGRT 1797
Score = 115 bits (288), Expect = 3e-25
Identities = 106/421 (25%), Positives = 179/421 (42%), Gaps = 56/421 (13%)
Query: 419 KPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN 478
+PA P ++P A V++R +RL W P ++ I+ FT+ + +
Sbjct: 1476 RPAPPRELLVPQAE-------VTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS 1528
Query: 479 TT-QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPG-PVENLQA 536
++ + V L+P Y R+ A N+ G + S + T + VPG P ++ A
Sbjct: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQ-DVPGEPPGSVSA 1587
Query: 537 VSTSPTSILITWEPPA--YANGPVQGYRLFCTEV-------------------------- 568
+ +S+LI W+PP NG +QGYR++ E+
Sbjct: 1588 TPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQ 1647
Query: 569 STGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQN 628
S+ K N +L LKK+ Y + AYN G ++ + V P+ PQN
Sbjct: 1648 SSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN 1707
Query: 629 VSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE----PNNLWYLFT 684
V + + + ++V+W PPP +QNG I GYKI + + + E E ++ P + L
Sbjct: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRL-K 1766
Query: 685 GLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII-M 743
L ++Y +SA G GP S+ P+ P PS L T+ + +
Sbjct: 1767 NLTSHTKYLVSISAFNAAGDGPKSD------PQQGRTHQAAPGAPSFLAFSEITSTTLNV 1820
Query: 744 SWTPPLNPNIVVRGYIIGYGVGSP---YAETVRVDSK---QRYYSIERLESSSHYVISLK 797
SW P N +++GY + Y +P ++ V V+ + QR+ + L Y ++
Sbjct: 1821 SWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQ 1880
Query: 798 A 798
A
Sbjct: 1881 A 1881
Score = 102 bits (254), Expect = 3e-21
Identities = 146/648 (22%), Positives = 244/648 (37%), Gaps = 87/648 (13%)
Query: 426 SVLPSAPRDVVPVLVSSRFVRLSWR--PPAEAKGNIQTFTVFF-SREGDNRERALNTTQP 482
SV +AP +V VSS + L+W P + G I + + F +++ D R+
Sbjct: 1274 SVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGN 1333
Query: 483 GSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPT 542
+ + L+ +Y +V+A+ G G S P+ + + + PGP L T
Sbjct: 1334 HTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPL-ILERTKDDAPGPPVRLVFPEVRLT 1392
Query: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKEQ--NIEVDGL--SYKLEGLKKFTEYSLRF 598
S+ I W+PP NG + GY++ S+ +EV + L + Y R
Sbjct: 1393 SVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRL 1452
Query: 599 LAYNRYGPGVSTDDITVVTLSDVPSAPPQN--VSLEVVNSRSIKVSWLPPPSGTQNGFIT 656
A R G G + + T APP+ V V +RS+++ W+P G+
Sbjct: 1453 SAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVP---GSDGASPI 1509
Query: 657 GYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP 716
Y + RGE +T S S + +A V+ P +++
Sbjct: 1510 RYFTMQVRELPRGEWQTYS--------------SSISHEATACVVDRLRPFTSYKLRLKA 1555
Query: 717 ENDLDESQ-------------VPDQP-SSLHVRPQT-NCIIMSWTPPLNPNIVVRGYIIG 761
ND+ +S VP +P S+ P T + +++ W PP + ++ G + G
Sbjct: 1556 TNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESL--NGLLQG 1613
Query: 762 YGVGSPYAETVRVDSKQRYYSIERLESSS-------HYVISLKAFNNAGEGVPLYESATT 814
Y + YY E+ S I+L A A S++T
Sbjct: 1614 YRI---------------YYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSST 1658
Query: 815 RSITDPTDPVDY---------YPLLDDFPTSVP-----DLSTPMLPPVGVQAVALTHDAV 860
++ + T Y Y ++ + P S P + P + P VQ LT +
Sbjct: 1659 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718
Query: 861 RVSWADNSVPKNQKTSEVRLYTVRWRT-SFSASAKYKSEDTTSLSYTATGLKPNTMYEFS 919
V+W D P++Q + W S + + K K L +T Y S
Sbjct: 1719 EVTW-DPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVS 1777
Query: 920 VMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITA 979
+ S T++AAP AP L E + VSW P ANG +
Sbjct: 1778 ISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAF--SEITSTTLNVSWGEPAAANGILQG 1834
Query: 980 Y-ILFYTLDKNIPIDDWIMETISGD-RLTHQIMDLNLDTMYYFRIQAR 1025
Y +++ L + + + G+ + ++ DL Y+FR+QAR
Sbjct: 1835 YRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQAR 1882
Score = 67.8 bits (164), Expect = 7e-11
Identities = 85/342 (24%), Positives = 131/342 (38%), Gaps = 55/342 (16%)
Query: 402 AENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPA--EAKGNI 459
A N G + SA P + AP++V +++ + ++W PP GNI
Sbjct: 1679 AYNIIGESPASA----PVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNI 1734
Query: 460 QTFTVFF----SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQ 515
Q + +++ S+ + + L +P + + NL Y + A+N G G S
Sbjct: 1735 QGYKIYYWEADSQNETEKMKVLFLPEP---VVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791
Query: 516 PIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVS----TG 571
P + T PG L + T++ ++W PA ANG +QGYR+ ++
Sbjct: 1792 PQQGRTHQA--APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVS 1849
Query: 572 KEQNIEVDG---LSYKLEGLKKFTEYSLRFLAYN-RYGPGVSTDDITVVTLSDVPSAPPQ 627
K +EV G K+ L K Y R A YGP + + +T +P
Sbjct: 1850 KVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQAN----ITAGPAEGSPGS 1905
Query: 628 NVSLEVVNSRS-IKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTG- 685
+ V S S + + W SG TGY I R + LW +F
Sbjct: 1906 PRDVLVTKSASELTLQWTEGHSGDTP--TTGYVIEARPSDE----------GLWDMFVKD 1953
Query: 686 --------------LEKGSQYSFQVSAMTVNGTGPPSNWYTA 713
L +G Y F+V A+ G G PSN TA
Sbjct: 1954 IPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTA 1995
Score = 58.9 bits (141), Expect = 3e-08
Identities = 69/270 (25%), Positives = 97/270 (35%), Gaps = 23/270 (8%)
Query: 180 LTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPASSRTGNEAEVRILS-DPGLH 237
L P PG PS GD G RC R A G +L+ L
Sbjct: 40 LAPRPGPE-----PSRPRAAPETSGGDTAGAGRCGGRRAAKLGPGRRGWWALLALQLHLL 94
Query: 238 RQL-------YFLQRPS-NVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSL 289
R L YF P + +EG VL C G P F W+R + + S +Y
Sbjct: 95 RALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKY 154
Query: 290 LGGSNLLISNVTDDDSGMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDI 348
+ I ++ D+G Y CVV + + +E+ V F++ +
Sbjct: 155 I------IPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAA 208
Query: 349 EFECT-VSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAG 407
++ P P V W + G +IPS+ I + L IL SD G Y A NE
Sbjct: 209 ILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKN 268
Query: 408 NAQTSAQLIVPKPAIPSSSVLPSAPRDVVP 437
++ I A + AP VVP
Sbjct: 269 GENKTSPFIHLSIARDVGTPETMAPTIVVP 298
Score = 32.3 bits (72), Expect = 3.4
Identities = 18/45 (40%), Positives = 24/45 (53%), Gaps = 1/45 (2%)
Query: 484 SLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVP 528
S L++ L+ Y FRVVA NE G GE S P A +++ P
Sbjct: 1960 SYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNP-STAVSAQVEAP 2003
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 256 bits (653), Expect = 1e-67
Identities = 192/589 (32%), Positives = 281/589 (47%), Gaps = 42/589 (7%)
Query: 40 LRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIK--WKKDGIHLALGMDERKQQLSNGSL 97
L F EPSD V + G ++LDC E G P ++ W+K+G+ L L+NGSL
Sbjct: 42 LAFAVEPSDDVAVPGQPIVLDCRVE---GTPPVRITWRKNGVELP--ESTHSTLLANGSL 96
Query: 98 LIQNILHSRHHKP-DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDT 156
+I++ P DEG Y+C A G ++SR A++ A F ++ G
Sbjct: 97 MIRHFRLEPGGSPSDEGDYECVAQ-NRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGV 155
Query: 157 VLLKCEVIGEPMPTIHWQKNQQDLTPIPGDS-RVVVLPSGALQISRLQPGDIGIYRCSAR 215
+C++ G P P I W+KN+ PI D+ R +LP G LQI+ L+ D GI+ C A
Sbjct: 156 ARFQCQIHGLPKPLITWEKNR---VPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVAS 212
Query: 216 NPASSRTGNEAEVRIL-SDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N AS R + A + + S G +++ L P N+ + AVLEC +G P P +W
Sbjct: 213 NIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS 272
Query: 275 R------GEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAE--LT 326
R G E IQ+ LG NL+IS+VT SG+Y C + +A+ L
Sbjct: 273 RLDGRPIGVEGIQV-------LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLV 325
Query: 327 VLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNL 385
V P F+ HP ++ F C G+P P V W+KNG V+ P + ++ S L
Sbjct: 326 VQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTL 385
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
I G+ DE YQCVAEN AG++Q SA+L + + LP PR+V V VSS V
Sbjct: 386 TISGIGPEDEAIYQCVAENSAGSSQASARL-----TVLWAEGLPGPPRNVRAVSVSSTEV 440
Query: 446 RLSWRPPAEAKGNIQTFTVFFSREGDNRE-RALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
R+SW P I + + + D E + Q V +L+P Y+F + A
Sbjct: 441 RVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKA 500
Query: 505 YNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLF 564
Y G +S P +T E P P+ +++ + +S S+ + WEP G++LF
Sbjct: 501 YTPRGASSASVPTLASTLGEAPAPPPL-SVRVLGSS--SLQLLWEPWPRLAQHEGGFKLF 557
Query: 565 CTEVS-TGKEQNIEVDGL--SYKLEGLKKFTEYSLRFLAYNRYGPGVST 610
S T I + G SY L L Y ++ LAYN++G G +T
Sbjct: 558 YRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT 606
Score = 112 bits (279), Expect = 3e-24
Identities = 147/617 (23%), Positives = 246/617 (39%), Gaps = 64/617 (10%)
Query: 235 GLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSN 294
G +L F PS+ VA+ G+ VL+C V G PP TW R V S +LL +
Sbjct: 37 GHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITW-RKNGVELPESTHSTLLANGS 95
Query: 295 LLISNV------TDDDSGMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMD 347
L+I + + D G Y CV + +S A + F HP E
Sbjct: 96 LMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGV 155
Query: 348 IEFECTVSGKPVPTVNWMKNG-DVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEA 406
F+C + G P P + W KN + ++ + ++ L+I G+ D G + CVA N
Sbjct: 156 ARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASN-- 213
Query: 407 GNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPA----EAKGNIQTF 462
A + + A + S S +LV + L+ A A GN +
Sbjct: 214 -----IASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI 268
Query: 463 TVFFSREG-DNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521
+ +G + G+L ++ ++ +Y V A N PG ++
Sbjct: 269 VSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVY---VCAANR--PGTR---VRRTA 320
Query: 522 QPELQVPGPVENLQ--------AVSTSPTSILITWEPPAYA----NGPVQGYRLFCTEVS 569
Q L V P E +Q A +T+ + EPP + NG V G
Sbjct: 321 QGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG--------- 371
Query: 570 TGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
G ++ + + + G+ E + +A N G ++ +TV+ +P PP+NV
Sbjct: 372 PGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGLP-GPPRNV 430
Query: 630 SLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM---ETLEPNNLWYLFTGL 686
V+S ++VSW P + T+ I GY + RK E+ E + + +L + L
Sbjct: 431 RAVSVSSTEVRVSWSEPLANTKE--IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDL 488
Query: 687 EKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWT 746
E + YSF + A T G S T + L E+ P P S+ V ++ ++ W
Sbjct: 489 EPSTAYSFYIKAYTPRGASSAS----VPTLASTLGEAPAP-PPLSVRVLGSSSLQLL-WE 542
Query: 747 PPLNPNIVVRGYIIGYGVGSPYAET--VRVDSKQRYYSIERLESSSHYVISLKAFNNAGE 804
P G+ + Y S + T + + Y++ +L+ ++ Y + L A+N G+
Sbjct: 543 PWPRLAQHEGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGD 602
Query: 805 GVPLYESATTRSITDPT 821
G + R ++ T
Sbjct: 603 GNATVRFVSLRGASERT 619
Score = 70.9 bits (172), Expect = 9e-12
Identities = 62/215 (28%), Positives = 97/215 (45%), Gaps = 17/215 (7%)
Query: 25 AHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKK-DGIHLAL 83
A L V+G A+ L P + +L+C A + P++ W + DG + +
Sbjct: 223 ARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPR-PIVSWSRLDGRPIGV 281
Query: 84 GMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTA--KVAVAGPLR 141
E Q L G+L+I ++ G+Y C A+ G+ + RTA ++ V P
Sbjct: 282 ---EGIQVLGTGNLIISDVTVQH-----SGVYVCAANR--PGTRVRRTAQGRLVVQAPAE 331
Query: 142 FLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISR 201
F+ +S++ G T + C+ GEP P + W KN Q L PG + + L IS
Sbjct: 332 FVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLG--PGGHVRLKNNNSTLTISG 389
Query: 202 LQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGL 236
+ P D IY+C A N A S + A + +L GL
Sbjct: 390 IGPEDEAIYQCVAENSAGSSQAS-ARLTVLWAEGL 423
Score = 43.1 bits (100), Expect = 0.002
Identities = 42/188 (22%), Positives = 78/188 (41%), Gaps = 12/188 (6%)
Query: 846 PPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE--DTTSL 903
PP V+AV+++ VRVSW++ T E+ Y + R + E ++
Sbjct: 426 PPRNVRAVSVSSTEVRVSWSEPLA----NTKEIIGYVLHIRKAADPPELEYQEAVSKSTF 481
Query: 904 SYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAV 963
+ + L+P+T Y F + R +S+ S+ A+T AP P + V+ ++
Sbjct: 482 QHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRVLGSS----SL 537
Query: 964 IVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQ 1023
+ W+P + LFY I+ + G ++ + L+ +Y ++
Sbjct: 538 QLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPIL--LPGTVSSYNLSQLDPTAVYEVKLL 595
Query: 1024 ARNSKGVG 1031
A N G G
Sbjct: 596 AYNQHGDG 603
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 251 bits (641), Expect = 4e-66
Identities = 278/1030 (26%), Positives = 443/1030 (43%), Gaps = 113/1030 (10%)
Query: 57 VLLDCSAESDRGVPVIK----WKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDE 112
V L+C A + P+IK WKKDG+ L+ G+ + ++L+ I N S D
Sbjct: 233 VTLECVANAR---PLIKLHIIWKKDGVLLSGGISDHNRRLT-----IPNPTGS-----DA 279
Query: 113 GLYQCEASLGDSG-SIISRTAKVAVAGPLRFLSQTES-VTAFMGDTVLLKCEVIGEPMPT 170
G Y+CEA L S + R A ++V P +F+ + E +TA M V + C+ G P P+
Sbjct: 280 GYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPS 339
Query: 171 IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASS-RTGNEAEVR 229
I W K+ + + +R G LQIS L P D G+++C ARN A +T V
Sbjct: 340 ITWYKDAA-VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398
Query: 230 ILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI---QLRSKK 286
++ P + R P + I+G VL C SG P P+ TW +GE ++ ++ +
Sbjct: 399 SIA-PNITRG------PLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPR 451
Query: 287 YSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESM 346
++ L +LLIS D+G YTC+ T ASA+L V P + +
Sbjct: 452 FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGT 511
Query: 347 DIEFECTVSGKPVPTVN--WMKNGDVVIPSDY--FQIVGGSNLRILGVVKSDEGFYQCVA 402
C V+ P T+ W K+G + + ++ +L I D G Y C
Sbjct: 512 QASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRV 571
Query: 403 ENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVL--VSSRFVRLSWRPPAEAKGNIQ 460
+ GN SA L V + LP AP V L V R + L+W P + +
Sbjct: 572 ISAGGNDSRSAHLRVRQ--------LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLI 623
Query: 461 TFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA 520
+ + S L + P + +TV L P Y FR+ A N+ G G+ S+ +
Sbjct: 624 RYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERV 683
Query: 521 TQPELQVPGPVENLQAVSTSPTSILITWEPP--AYANGPVQGY--RLFCTEVSTGKE-QN 575
+ PE P +N+ A + SI+I W+PP ++ NG ++GY R + G + +N
Sbjct: 684 SLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKN 743
Query: 576 I-EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV 634
I + D + LE L +T Y + AYN G GV + +T TL VP+ PP NV E
Sbjct: 744 ITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEAT 803
Query: 635 NSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE--METLEPN-----NLWYLFTGLE 687
NS +I+ +W P NG GYK+ + + E M T PN ++ ++ +GL+
Sbjct: 804 NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFV-SGLK 862
Query: 688 KGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII-MSWT 746
K ++Y V T G GP S TP+ VP L + + +SW
Sbjct: 863 KFTEYFTSVLCFTTPGDGPRS------TPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQ 916
Query: 747 PPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY--------YSIERLESSSHYVISLKA 798
P N ++ GY I + E R +++ + Y + L + + Y I + A
Sbjct: 917 EPGEKNGILTGYRIS------WEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
Query: 799 FNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHD 858
+ G+G SA+T S P P L PT++ + +G ++V L
Sbjct: 971 MTSKGQG---QVSASTISSGVP-------PELPGPPTNLG------ISNIGPRSVTL--- 1011
Query: 859 AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEF 918
R + D ++ E ++ V + + S + + S L P T Y F
Sbjct: 1012 QFRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQL-SNEPDARSMEVPDLNPFTCYSF 1069
Query: 919 SVMVTKNRRSSTWSMTAH-ATTYEAAPTSAPKDLTVITREGKPRAVIVSWQ--PPLEANG 975
+ +S S + T +A P AP ++++ R ++ + W P +E NG
Sbjct: 1070 RMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSL--RTASETSLWLRWMPLPEMEYNG 1127
Query: 976 --KITAYILFYTLD--KNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVG 1031
+ Y + Y+ + + + + D + I DL T Y ++QA N+ G G
Sbjct: 1128 NPESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNAIGSG 1184
Query: 1032 PLSDPILFRT 1041
P S ++ RT
Sbjct: 1185 PWSQTVVGRT 1194
Score = 157 bits (397), Expect = 7e-38
Identities = 191/708 (26%), Positives = 285/708 (40%), Gaps = 105/708 (14%)
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
R+ G+ + A G Q SA I +P LP P ++ + R V
Sbjct: 954 RVTGLTALTTYTIEVAAMTSKGQGQVSASTI--SSGVPPE--LPGPPTNLGISNIGPRSV 1009
Query: 446 RLSWRPPAEAKGNIQTFTVF--FSREGDNRERALN---TTQPGSLQLTVGNLKPEAMYTF 500
L +RP + K +I + V G+ E L + +P + + V +L P Y+F
Sbjct: 1010 TLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069
Query: 501 RVVAYNEWGPGESSQPI-KVATQPELQVPGPVE--NLQAVSTSPTSILITWEP---PAYA 554
R+ N G SQP K+ T LQ P + N+ + S TS+ + W P Y
Sbjct: 1070 RMRQVNIVGTSPPSQPSRKIQT---LQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYN 1126
Query: 555 NGPVQ-GYRL-FCTEVSTGK------EQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGP 606
P GY++ + GK + +E D Y +E L+++TEY ++ A+N G
Sbjct: 1127 GNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNAIGS 1183
Query: 607 GVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTT 666
G + + T VPS+ P NVS S S+ V W P +NG + GYK+ ++
Sbjct: 1184 GPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYK--- 1240
Query: 667 RRGEMETLEPNNLWYL---------FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPE 717
E ++ W + TGL K Y QV A T G G PS+ E
Sbjct: 1241 ---EKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSH---PPILE 1294
Query: 718 NDLDESQVPDQPSS-LHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVD- 775
LD+ VP P L +T + + W PP PN ++ Y I + + + A T V+
Sbjct: 1295 RTLDD--VPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEV 1352
Query: 776 --SKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDF 833
R Y+ L+ S Y+ + A G G T D P
Sbjct: 1353 LAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPP--------- 1403
Query: 834 PTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASA 893
S PM+ V+A +V +SW P + S VR YT++ R S
Sbjct: 1404 -------SRPMVQQEDVRA-----RSVLLSWE----PGSDGLSPVRYYTIQTRELPSGRW 1447
Query: 894 KYKSEDTT--SLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA-TTYEAAPTSAPKD 950
S + + S+ LKP T Y+F V T + S +S + + TT +AAP AP
Sbjct: 1448 ALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI 1507
Query: 951 LTVITREGKPRAVIVSWQPPLE--ANGKITAYILFY-----------TL-DKNIPIDDWI 996
L+V +V++ WQPP E NG + + + Y TL N P W
Sbjct: 1508 LSVTPH--TTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWA 1565
Query: 997 -------METISGDRLT-HQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
M +S LT +++ +LN Y R+ N+ G GP S P
Sbjct: 1566 ELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPP 1613
Score = 136 bits (343), Expect = 1e-31
Identities = 155/640 (24%), Positives = 252/640 (39%), Gaps = 82/640 (12%)
Query: 445 VRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
+++SW+ P E G + + + + R + +L+ V L YT V A
Sbjct: 911 LKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
Query: 505 YNEWGPGE-SSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRL 563
G G+ S+ I PEL PGP NL + P S+ + + P + + +
Sbjct: 971 MTSKGQGQVSASTISSGVPPEL--PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLV 1028
Query: 564 FCT--EVSTGKEQNI------EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPG-VSTDDIT 614
V G+E + E D S ++ L FT YS R N G S
Sbjct: 1029 EAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
Query: 615 VVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNG--FITGYKIR------HRKTT 666
+ TL P P NVSL + S+ + W+P P NG GYKI+ H KT
Sbjct: 1089 IQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148
Query: 667 RRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVP 726
+ +E + Y LE+ ++Y QV A G+GP S T E+ S P
Sbjct: 1149 SHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRES--VPSSGP 1203
Query: 727 DQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERL 786
S+L + + S P + N +V GY + Y + D++ R++ +E
Sbjct: 1204 TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMY-------KEKDSDTQPRFWLVEGN 1256
Query: 787 ESSSH----------YVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTS 836
S S Y + + AF G+G P + R+ LDD P
Sbjct: 1257 SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERT-------------LDDVPG- 1302
Query: 837 VPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYK 896
PP+G+ + +VR+ W + P T R T+ + +A +
Sbjct: 1303 ---------PPMGILFPEVRTTSVRLIWQPPAAPNG--IILAYQITHRLNTTTANTATVE 1351
Query: 897 SEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITR 956
++ YTATGLKP ++Y F + + R+ + A T E P ++ +
Sbjct: 1352 VLAPSARQYTATGLKPESVYLFRI-TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ 1410
Query: 957 EG-KPRAVIVSWQPPLEANGKITAYILFYTLD-KNIPIDDWIMETISGDRLTHQIMDLNL 1014
E + R+V++SW+P + + + +YT+ + +P W + + S ++H +
Sbjct: 1411 EDVRARSVLLSWEPGSDG----LSPVRYYTIQTRELPSGRWALHSAS---VSHNASSFIV 1463
Query: 1015 D-----TMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDK 1049
D T Y FR++A N G S+ T PD+
Sbjct: 1464 DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDE 1503
Score = 134 bits (336), Expect = 8e-31
Identities = 238/1075 (22%), Positives = 390/1075 (36%), Gaps = 168/1075 (15%)
Query: 42 FLSEP-SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ 100
F +EP V + G ++L C AE + KW +H ++L+ SL +
Sbjct: 28 FKTEPVRTQVHLEGNRLVLTCMAEGSWPLE-FKW----LH-------NNRELTKFSLEYR 75
Query: 101 NILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK 160
++ S + G Y+C G+++ R +V VA F + + G+ +++
Sbjct: 76 YMITSLD-RTHAGFYRCIVR-NRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIR 133
Query: 161 CEVIGE-PMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
I P P + W + D IP SR+ + L I D G Y A N +
Sbjct: 134 APRIASFPQPQVTWFR---DGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKN 190
Query: 220 SRTGNEAEVRI----LSDPGLHRQLYFLQRPSNVVAIEGKDAV-LECCVSGYPPPSFTWL 274
+ + + P + P N + G V LEC + P
Sbjct: 191 GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARP------- 243
Query: 275 RGEEVIQLR---SKKYSLLGGS------NLLISNVTDDDSGMYTCVVTYKNENISA---S 322
+I+L K LL G L I N T D+G Y C ++ ++ +
Sbjct: 244 ----LIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 299
Query: 323 AELTVLVPPWFLNHPS-NLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--FQI 379
A L+VL PP F+ P ++ A ++ C G P P++ W K+ VV F+
Sbjct: 300 AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ 359
Query: 380 VGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVP-V 438
L+I G+V D G +QC A N AG QTS L V +S+ P+ R +
Sbjct: 360 RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV-------TSIAPNITRGPLDST 412
Query: 439 LVSSRFVRLSWRPPAEAKGNIQTFTVFFSRE-----GDNRERALNTTQPGSLQLTVGNLK 493
++ V L+ E G + + E G + + GSL ++ ++
Sbjct: 413 VIDGMSVVLA----CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS 468
Query: 494 PEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVP----GPVENLQA-----VSTSP-TS 543
YT +A N G E+S + V + + P ++ QA V+ P +
Sbjct: 469 DAGTYT--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT 526
Query: 544 ILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVD---GLSYKLEGLKKFTEYSLRFLA 600
I WE G T I +D L Y+ R ++
Sbjct: 527 IRYIWEKDGATLG-------------TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVIS 573
Query: 601 YNRYGPGVSTDDITVVTLSDVPSAPPQNVS-LEVVNSRSIKVSWLPPPSGTQNGFITGYK 659
G + + + +P AP V+ L V R+I ++W P G +
Sbjct: 574 -----AGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE 628
Query: 660 IRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPEND 719
+ + +++P GL Y F++ A+ G G ++ +T
Sbjct: 629 MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ----FSKDTERVS 684
Query: 720 LDESQVPDQPSSLHVRPQTN-CIIMSWTPP--LNPNIVVRGYIIGY---GVGSPYAETVR 773
L E P ++ +TN I++ W PP + N +++GYII Y G+ Y
Sbjct: 685 LPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNI 744
Query: 774 VDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDF 833
D+ +E L ++Y I + A+N+AG GV Y S T
Sbjct: 745 TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV--YSSKVTEWTLQ-------------- 788
Query: 834 PTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVR--LYTVRWRTSFS- 890
P +PP V A A +R +W + P Q + + + W
Sbjct: 789 -------GVPTVPPGNVHAEATNSTTIRFTW---NAPSPQFINGINQGYKLIAWEPEQEE 838
Query: 891 ----ASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTS 946
+A+ +D+ + + + GLK T Y SV+ S T+E P
Sbjct: 839 EVTMVTARPNFQDSIHVGFVS-GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGP 897
Query: 947 APKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLT 1006
+ E ++ VSWQ P E NG +T Y + W + R+T
Sbjct: 898 VGH---LSFSEILDTSLKVSWQEPGEKNGILTGYRI-----------SWEEYNRTNTRVT 943
Query: 1007 HQIMDLNLD---------TMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMAN 1052
H + ++ L+ T Y + A SKG G +S + + E P N
Sbjct: 944 HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTN 998
Score = 117 bits (293), Expect = 8e-26
Identities = 208/925 (22%), Positives = 330/925 (35%), Gaps = 200/925 (21%)
Query: 426 SVLPSAPRDVVPVLV--SSRFVRLSWRPPAEAKGNIQTFTVFFS-REGDNRERALNTTQP 482
SV S P +V + SS VR S P A+ G + + V + ++ D + R
Sbjct: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
Query: 483 GSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPT 542
S + L +Y +V+A+ G G S P + + VPGP + T
Sbjct: 1257 SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP-PILERTLDDVPGPPMGILFPEVRTT 1315
Query: 543 SILITWEPPAYANGPVQGY----RLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRF 598
S+ + W+PPA NG + Y RL T +T + + Y GLK + Y R
Sbjct: 1316 SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375
Query: 599 LAYNRYGPGVSTDDITVVTLSDVPSAPPQN--VSLEVVNSRSIKVSWLPPPSGTQNGFIT 656
A R G G + + + V T PP V E V +RS+ +SW P G +
Sbjct: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSP--VR 1433
Query: 657 GYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP 716
Y I+ R+ P+ W L + + S S+ V+ P +++
Sbjct: 1434 YYTIQTREL----------PSGRWALHS-----ASVSHNASSFIVDRLKPFTSYKFRVKA 1478
Query: 717 ENDLDESQ-------------VPDQ-PSSLHVRPQTNC-IIMSWTPPLNPNI--VVRGYI 759
ND+ +S+ PD+ P+ L V P T +++ W PP I ++ G+
Sbjct: 1479 TNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFR 1538
Query: 760 IGY--------------GVGSP---YAETVRVDSKQRY-------YSIERLESSSHYVIS 795
I Y G+ +P +AE + S + Y ++ L Y I
Sbjct: 1539 IRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIR 1598
Query: 796 LKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL 855
+ +N GEG P+ P + + PT+ P V
Sbjct: 1599 MSVYNAVGEG--------------PSSPPQEVFVGEAVPTAAPR---------NVVVHGA 1635
Query: 856 THDAVRVSWADNSVPKNQKTSEVRLY------------TVRWRTSFSASAKYKSEDTTSL 903
T + V+W P + + +++ Y T R +T F A K ++ T
Sbjct: 1636 TATQLDVTW--EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG- 1692
Query: 904 SYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAV 963
YTA Y SV S T +AAP SAP +V E +V
Sbjct: 1693 -YTA--------YMVSVAAFNAAGDGPRSTPTQGQTQQAAP-SAPS--SVKFSELTTTSV 1740
Query: 964 IVSWQPPLEANGKITAYILFYTLDKNIPIDD----WIMETISGDRLTHQIMDLNLDTMYY 1019
VSW+ P NG + Y L Y + P+D ++ L ++ DL Y
Sbjct: 1741 NVSWEAPQFPNGILEGYRLVY--EPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYR 1798
Query: 1020 FRIQAR----------------NSKGVGPLSDPILFRTLKVEHPDKMANDQG-------- 1055
FRI+A+ GP PI+ R + D G
Sbjct: 1799 FRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYV 1858
Query: 1056 ---RHGDGGYWPVDTNLIDRS----------------------TLNEPPIGQMHPPHGSV 1090
R D G W + I + +N+ G P SV
Sbjct: 1859 IEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSV 1918
Query: 1091 TPQKNSNL-----LVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKG-- 1143
QK + ++++ VG+I +L++V V +I R S + KK + ++ K
Sbjct: 1919 PAQKANPFYEEWWFLVVIALVGLIFILLLVFVLII--RGQSKKYAKKTDSGNSAKSGALG 1976
Query: 1144 -----SQKDLRPPDLWIHHEEMEMKNI------------EKPSGTDPAGRDSPIQSCQDL 1186
S + P L +++ + +KN +PS D + DL
Sbjct: 1977 HSEMMSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDL 2036
Query: 1187 TPVSHSQSETQLGSKSTSHSGQDTE 1211
P + S S T+ S+ + G D+E
Sbjct: 2037 IP-AESSSLTEKPSEISDSQGSDSE 2060
Score = 90.1 bits (222), Expect = 1e-17
Identities = 87/344 (25%), Positives = 143/344 (41%), Gaps = 53/344 (15%)
Query: 398 YQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVS-----SRFVRLSWRPP 452
++ A N+ G+++ S + S + L +AP D P ++S + V + W+PP
Sbjct: 1474 FRVKATNDIGDSEFSEES-------ESLTTLQAAP-DEAPTILSVTPHTTTSVLIRWQPP 1525
Query: 453 AEAK--GNIQTFTVF-----------FSREGDNRERAL-----------NTTQPGSLQLT 488
AE K G + F + F+ G N A N ++P Q
Sbjct: 1526 AEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYE 1585
Query: 489 VGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITW 548
+ NL Y R+ YN G G SS P +V + P N+ + T + +TW
Sbjct: 1586 LDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAP-RNVVVHGATATQLDVTW 1644
Query: 549 EPPAY--ANGPVQGYRLFCTEVSTG----KEQNIEVDGLSYKLEGLKKFTEYSLRFLAYN 602
EPP NG +QGY+++ E G + + + + S KL+ L +T Y + A+N
Sbjct: 1645 EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFN 1704
Query: 603 RYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRH 662
G G + T PSA P +V + + S+ VSW P NG + GY++ +
Sbjct: 1705 AAGDGPRSTPTQGQTQQAAPSA-PSSVKFSELTTTSVNVSWEAPQ--FPNGILEGYRLVY 1761
Query: 663 RK------TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMT 700
++ ++ + LW L +G Y F++ A T
Sbjct: 1762 EPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT 1805
Score = 82.0 bits (201), Expect = 4e-15
Identities = 86/311 (27%), Positives = 137/311 (44%), Gaps = 29/311 (9%)
Query: 418 PKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPA--EAKGNIQTFTVFF--SREGDNR 473
P+ +V +APR+VV ++ + ++W PP G+IQ + ++F ++ G+
Sbjct: 1613 PQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLT 1672
Query: 474 ERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVEN 533
ER + T + + NL Y V A+N G G S P + TQ P +
Sbjct: 1673 ER-VKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQA--APSAPSS 1729
Query: 534 LQAVSTSPTSILITWEPPAYANGPVQGYRLF---CTEV-STGKEQNIEVDG---LSYKLE 586
++ + TS+ ++WE P + NG ++GYRL C+ V K ++V G L K++
Sbjct: 1730 VKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVK 1789
Query: 587 GLKKFTEYSLRFLAYN-RYGPGVSTDDITVVTLSDVPSAP-PQNVSLEVVNSRSIKVSWL 644
L + Y R A YGP + + VT AP P V + V S +I + W
Sbjct: 1790 DLAEGVTYRFRIRAKTFTYGPEIEAN----VTTGPGEGAPGPPGVPIIVRYSSAIAIHWS 1845
Query: 645 PPPSGTQNGFITGYKIRHRKTTRRGEMETL------EPNNLWYLFTGLEKGSQYSFQVSA 698
G G IT Y I R + G + L E ++ + L+ G Y F+V A
Sbjct: 1846 SGDPG--KGPITRYVIEARPSD-EGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
Query: 699 MTVNGTGPPSN 709
+ G G PS+
Sbjct: 1903 VNDYGFGTPSS 1913
Score = 49.3 bits (116), Expect = 3e-05
Identities = 47/200 (23%), Positives = 73/200 (36%), Gaps = 9/200 (4%)
Query: 241 YFLQRPSNV-VAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISN 299
YF P V +EG VL C G P F WL + S +Y +I++
Sbjct: 27 YFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEY------RYMITS 80
Query: 300 VTDDDSGMYTCVVTYK-NENISASAELTVLVPPWF-LNHPSNLYAYESMDIEFECTVSGK 357
+ +G Y C+V + + E+ V F ++ + ++
Sbjct: 81 LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF 140
Query: 358 PVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV 417
P P V W ++G + PS I + L IL V D G Y A N+ ++Q I
Sbjct: 141 PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPIT 200
Query: 418 PKPAIPSSSVLPSAPRDVVP 437
P AP ++P
Sbjct: 201 LTVENVGGPADPIAPTIIIP 220
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 250 bits (639), Expect = 6e-66
Identities = 265/925 (28%), Positives = 393/925 (42%), Gaps = 117/925 (12%)
Query: 58 LLDCSAESDRGVPV--IKWKKDGIHLALGMDERKQQLSNGSLLIQNILH---SRHHKPD- 111
+L+CS + P + W KDG L + L NGSL + L S P+
Sbjct: 54 VLNCSLGAAAAGPPTRVTWSKDGDTLL--EHDHLHLLPNGSLWLSQPLAPNGSDESVPEA 111
Query: 112 ----EGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEP 167
EG Y C A G G + S+TA V +A F ES T T +C + G P
Sbjct: 112 VGVIEGNYSCLAH-GPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGLP 170
Query: 168 MPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAE 227
P I W+K+Q +P + R++VLP+G LQI +Q D G YRC A N A EA
Sbjct: 171 APIITWEKDQ---VTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEAL 227
Query: 228 VRILSDPGL----HRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR--GEEVIQ 281
+ + L + + + P N + G+ V+EC S P P +W+R G+ +
Sbjct: 228 LSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPI-- 285
Query: 282 LRSKKYSLLGGSNLLISNVTDDDSGMYTCVVT--YKNENISASAELTVLVPPWFLNHPSN 339
S +LG +NLLI+N SG+Y C + +A+AEL VL P P
Sbjct: 286 --STDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEA 343
Query: 340 LYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNLRILGVVKSDEGFY 398
L + F C SG+P P + W+ NG + P+ ++ GG +L I + D G+Y
Sbjct: 344 LSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYY 403
Query: 399 QCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGN 458
QCVAEN AG A +A L A+ LPSAP V +SS V ++W P
Sbjct: 404 QCVAENSAGMACAAASL-----AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQ 458
Query: 459 IQTFTVFF--SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQP 516
I F++ + +R DN E + +L V +L+P Y F VVAY++ G +S P
Sbjct: 459 IIGFSLHYQKARGMDNVEYQF-AVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTP 517
Query: 517 IKVATQPELQVPGPVENLQAVSTSPTSILITW--EPPAYANGPVQGYRLFCTEVSTGKEQ 574
V T + VP L S +P+ I + W PP+ +NG V Y++ E GKE
Sbjct: 518 ALVHTLDD--VPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKI---EYGLGKED 572
Query: 575 NI---EVDG--LSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDI-----TVVTLSDVPSA 624
I EV G L L+ Y +R A G G + + ++ S VP A
Sbjct: 573 QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFA 632
Query: 625 PPQNVSLEV-VNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEME----------- 672
P + L+V S+ VSW PPP TQ I+GYK+ R+ E
Sbjct: 633 PAE---LKVQAKMESLVVSWQPPPHPTQ---ISGYKLYWREVGAEEEANGDRLPGGRGDQ 686
Query: 673 -------TLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNW--YTAETPENDLDES 723
L+ Y T L G Y ++ A + G + W T + P D+
Sbjct: 687 AWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQ 746
Query: 724 QVPDQPSSLHVRPQTN---CIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
+ P P + HV ++N I + W P + + Y + + SP+ +R S Y
Sbjct: 747 RGPPLPPA-HVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRF---SPWG--LRNASLVTY 800
Query: 781 YSIERLESSSHYVI--SLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838
Y+ SS ++ LK F YE A D P + +++ +++P
Sbjct: 801 YT-----SSGEDILIGGLKPFTK-------YEFAVQSHGVDMDGP--FGSVVE--RSTLP 844
Query: 839 DLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE 898
D P PP ++ LT VR+ W P + E+ Y + + ++ + +
Sbjct: 845 D--RPSTPPSDLRLSPLTPSTVRLHWC----PPTEPNGEIVEYLILYSSNHTQPEHQWTL 898
Query: 899 DTTS---LSYTATGLKPNTMYEFSV 920
TT S GL+ +T Y F +
Sbjct: 899 LTTQGNIFSAEVHGLESDTRYFFKM 923
Score = 226 bits (576), Expect = 1e-58
Identities = 226/921 (24%), Positives = 360/921 (39%), Gaps = 104/921 (11%)
Query: 167 PMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISR---------LQPGDIGI----YRCS 213
P + W K+ L + +LP+G+L +S+ P +G+ Y C
Sbjct: 66 PPTRVTWSKDGDTLLE---HDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCL 122
Query: 214 ARNPASSRTGNEAEVRI--LSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF 271
A P A V++ L+D LH P + E A EC + G P P
Sbjct: 123 AHGPLGVLASQTAVVKLATLADFSLH--------PESQTVEENGTARFECHIEGLPAPII 174
Query: 272 TWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYK-NENISASAELTVL-- 328
TW + ++V + +L L I +V + D+G Y CV T ++ S A L+V
Sbjct: 175 TWEK-DQVTLPEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHR 233
Query: 329 --------VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV 380
+ P N + EC S P P V+W++ I +D ++
Sbjct: 234 GSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVI-VL 292
Query: 381 GGSNLRILGVVKSDEGFYQCVAENEAGN--AQTSAQL-IVPKPAIPSSSVLPSAPRDVVP 437
G +NL I G Y C A A +A+L ++ PAI + S R
Sbjct: 293 GRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTR---- 348
Query: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAM 497
++RFV A G + + R Q G L + + +
Sbjct: 349 -ASTARFV-------CRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDA 400
Query: 498 YTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGP 557
++ VA N G ++ + V + L P + A S +++L+ WE P +
Sbjct: 401 GYYQCVAENSAGMACAAASLAVVVREGL--PSAPTRVTATPLSSSAVLVAWERPEMHSEQ 458
Query: 558 VQGYRLFCTEV----STGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDI 613
+ G+ L + + + + D ++ L+ T+Y +AY++ G ++
Sbjct: 459 IIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPA 518
Query: 614 TVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET 673
V TL DVPSA PQ +SL N I+V+WLP P NG + YKI + T
Sbjct: 519 LVHTLDDVPSAAPQ-LSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKEDQIFST 577
Query: 674 -LEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSL 732
+ N + L+ Y ++SA T G G PS W TP ++S VP P+ L
Sbjct: 578 EVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMH-NQSHVPFAPAEL 636
Query: 733 HVRPQTNCIIMSWTPPLNPNIVVRGYII------------------GYGVGSPYAETVRV 774
V+ + +++SW PP +P + GY + G G + VR+
Sbjct: 637 KVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRL 695
Query: 775 DSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFP 834
K + Y + +L Y + L AFN +G T P P+
Sbjct: 696 KKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQ--------- 746
Query: 835 TSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAK 894
P LPP V A + + ++ + W T ++ YTVR+ +A
Sbjct: 747 ------RGPPLPPAHVHAESNSSTSIWLRWKKPDFT----TVKIVNYTVRFSPWGLRNAS 796
Query: 895 YKSEDTTS-LSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTV 953
+ T+S GLKP T YEF+V + +T P++ P DL +
Sbjct: 797 LVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRL 856
Query: 954 ITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLN 1013
P V + W PP E NG+I Y++ Y+ + P W + T G+ + ++ L
Sbjct: 857 SPLT--PSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLE 914
Query: 1014 LDTMYYFRIQARNSKGVGPLS 1034
DT Y+F++ AR G GP S
Sbjct: 915 SDTRYFFKMGARTEVGPGPFS 935
Score = 79.0 bits (193), Expect = 3e-14
Identities = 77/333 (23%), Positives = 136/333 (40%), Gaps = 32/333 (9%)
Query: 420 PAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNT 479
P++ + S +P AP ++ V + +SW+PP I + +++ RE E A
Sbjct: 621 PSMHNQSHVPFAPAEL-KVQAKMESLVVSWQPPPHPT-QISGYKLYW-REVGAEEEANGD 677
Query: 480 TQPGSL-----------------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQ---PIKV 519
PG Q + L P +Y ++VA+N+ G ++ +
Sbjct: 678 RLPGGRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEK 737
Query: 520 ATQPELQV----PGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQN 575
A P++ + P P ++ A S S TSI + W+ P + + Y + +
Sbjct: 738 APAPDMPIQRGPPLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASL 797
Query: 576 IEV---DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLE 632
+ G + GLK FT+Y ++ G + TL D PS PP ++ L
Sbjct: 798 VTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLS 857
Query: 633 VVNSRSIKVSWLPP--PSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGS 690
+ ++++ W PP P+G ++ Y H + + + T + N GLE +
Sbjct: 858 PLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDT 917
Query: 691 QYSFQVSAMTVNGTGPPSNWYTAETPENDLDES 723
+Y F++ A T G GP S T + L +S
Sbjct: 918 RYFFKMGARTEVGPGPFSRLQDVITLQEKLSDS 950
Score = 55.1 bits (131), Expect = 5e-07
Identities = 47/180 (26%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 43 LSEPSDAVTMRGGNVLLDCSAESDRGVPVIKW-KKDGIHLALGMDERKQQLSNGSLLIQN 101
++ P + + G +V+++C A +D P + W ++DG ++ + L +LLI N
Sbjct: 247 VAAPENTTVVSGQSVVMECVASAD-PTPFVSWVRQDGKPISTDV----IVLGRTNLLIAN 301
Query: 102 I--LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
HS G+Y C A+ + + A++ V E+++ T
Sbjct: 302 AQPWHS-------GVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARF 354
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVL-PSGALQISRLQPGDIGIYRCSARNPA 218
C GEP P + W N L P + RV V G+L I+++ D G Y+C A N A
Sbjct: 355 VCRASGEPRPALRWLHNGAPLRP---NGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSA 411
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 234 bits (598), Expect = 3e-61
Identities = 279/1049 (26%), Positives = 416/1049 (39%), Gaps = 123/1049 (11%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ--QLSNGSLL 98
RF+ EP D + + GG C A D P + W K G + E + + + L
Sbjct: 34 RFIKEPKDQIGVSGGVASFVCQATGDPK-PRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 99 IQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF----MG 154
IQ + R DE +Y+C A + ++ V L L + + + F MG
Sbjct: 93 IQPLRTPR----DENVYECVAQ--------NSVGEITVHAKLTVLREDQLPSGFPNIDMG 140
Query: 155 D---------TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPG 205
T + C G P P I W K+ + P + R+ L SGALQI +
Sbjct: 141 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEET 200
Query: 206 DIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSG 265
D G Y C A N A R + A + + R F P + + G + + C G
Sbjct: 201 DQGKYECVATNSAGVRYSSPANLYVRVRRVAPR---FSILPMSHEIMPGGNVNITCVAVG 257
Query: 266 YPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTD-DDSGMYTCVVTYKNENISASAE 324
P P W++G E + + + + G N+L +TD DS YTCV I A A+
Sbjct: 258 SPMPYVKWMQGAEDL---TPEDDMPVGRNVL--ELTDVKDSANYTCVAMSSLGVIEAVAQ 312
Query: 325 LTVLVPPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWM---KNGDVVIPSDYFQIV 380
+TV P P E+ T SG P P ++ K+ P + +
Sbjct: 313 ITVKSLP---KAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDI 369
Query: 381 GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLV 440
+ I G+ + E A N G S ++ SAPR+V ++
Sbjct: 370 TTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT----GEQAPASAPRNVQARML 425
Query: 441 SSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQP----GSLQLTVGNLKPEA 496
S+ + + W P E G I+ + V+++ E E + Q SL TVG+L +
Sbjct: 426 SATTMIVQWEEPVEPNGLIRGYRVYYTMEP---EHPVGNWQKHNVDDSLLTTVGSLLEDE 482
Query: 497 MYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANG 556
YT RV+A+ G G S PI+V TQ VPG NL+A + S TSI ++W PP +
Sbjct: 483 TYTVRVLAFTSVGDGPLSDPIQVKTQQG--VPGQPMNLRAEARSETSITLSWSPPRQES- 539
Query: 557 PVQGYRLFCTEVSTGKEQNIEVDGL-SYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITV 615
+ Y L E G+E D SY +E LK TEY+ R A + G G T +
Sbjct: 540 -IIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ 598
Query: 616 VTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR----KTTRRGEM 671
TL PSAPPQ+V V S +I VSW PPP T NG + GY +R+R + E+
Sbjct: 599 RTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEV 658
Query: 672 ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSS 731
+ P L LEK +QY A T G GP S+ T E D P +
Sbjct: 659 NGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDE---DVPSAPPRKVE 715
Query: 732 LHVRPQTNCIIMSWTP-PLNPNIVVRGYIIGY-------GVGSPYAETVRVDSKQRYYSI 783
T ++ +P P + +RGY + Y G P + V + Q I
Sbjct: 716 AEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMV-I 774
Query: 784 ERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTP 843
L+ + Y I++ A+ G+G + + P V +L P LS
Sbjct: 775 TNLQPETAYSITVAAYTMKGDG----------ARSKPKVVVTKGAVL-----GRPTLSVQ 819
Query: 844 MLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKY-KSEDTTS 902
P ++ W + + RL R ++ A+ ++ SED
Sbjct: 820 QTP----------EGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSED--- 866
Query: 903 LSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRA 962
YTA+G+ Y F + ++R + E P P+ L
Sbjct: 867 -RYTASGVHKGATYVFR-LAARSRGGLGEEAAEVLSIPEDTPRGHPQILEA-AGNASAGT 923
Query: 963 VIVSWQPPL--EANGKITAY--------ILFYTLDKNIPIDDWIMETISGDRLTHQIMDL 1012
V++ W PP+ E NG I Y L + +P E + + LT + L
Sbjct: 924 VLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPA---AAEPGAENALT--LQGL 978
Query: 1013 NLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
DT Y +++A +G GP S P+ +RT
Sbjct: 979 KPDTAYDLQVRAHTRRGPGPFSPPVRYRT 1007
Score = 196 bits (499), Expect = 1e-49
Identities = 231/943 (24%), Positives = 372/943 (39%), Gaps = 110/943 (11%)
Query: 135 AVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQK-----NQQDLTPIPGDSRV 189
A P RF+ + + G C+ G+P P + W K N Q I D
Sbjct: 28 AAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESA 87
Query: 190 VVLPSGALQISRLQ-PGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSN 248
L+I L+ P D +Y C A+N T + A++ +L + L +
Sbjct: 88 ----GAVLRIQPLRTPRDENVYECVAQNSVGEITVH-AKLTVLREDQLPSGFPNIDMGPQ 142
Query: 249 VVAIE-GKDAVLECCVSGYPPPSFTWLRGEEVI--QLRSKKYSLLGGSNLLISNVTDDDS 305
+ +E + A + C SG P P TW + + + + L L I + + D
Sbjct: 143 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQ 202
Query: 306 GMYTCVVTYK-NENISASAELTV---LVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPT 361
G Y CV T S+ A L V V P F P + ++ C G P+P
Sbjct: 203 GKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY 262
Query: 362 VNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPA 421
V WM+ + + P D + G N+ L VK D Y CVA + G + AQ+ V
Sbjct: 263 VKWMQGAEDLTPEDDMPV--GRNVLELTDVK-DSANYTCVAMSSLGVIEAVAQITVKS-- 317
Query: 422 IPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFF------SREGDNRER 475
LP AP + ++ + ++W GN + + S++G + +
Sbjct: 318 ------LPKAPGTPMVTENTATSITITW-----DSGNPDPVSYYVIEYKSKSQDGPYQIK 366
Query: 476 ALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQ 535
TT + ++G L P + Y V A N G G S+ + T + P N+Q
Sbjct: 367 EDITT----TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP-RNVQ 421
Query: 536 AVSTSPTSILITWEPPAYANGPVQGYRLFCT-----EVSTGKEQNIEVDGLSYKLEGLKK 590
A S T++++ WE P NG ++GYR++ T V ++ N++ D L + L +
Sbjct: 422 ARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVD-DSLLTTVGSLLE 480
Query: 591 FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
Y++R LA+ G G +D I V T VP P N+ E + SI +SW PP
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPP---- 535
Query: 651 QNGFITGYKIRHRKTTRRGEM-ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSN 709
+ I Y++ R+ E+ T +P Y+ L+ ++Y+F+++A + G G
Sbjct: 536 RQESIIKYELLFREGDHGREVGRTFDPTTS-YVVEDLKPNTEYAFRLAARSPQGLGA--- 591
Query: 710 WYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGV----- 764
+T + L V ++ I++SW PP P G ++GY V
Sbjct: 592 -FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPP--PPETHNGALVGYSVRYRPL 648
Query: 765 GSPYAETVRVDS---KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPT 821
GS E V+ +E LE + Y I+ A G G P R+
Sbjct: 649 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG-PESSPVVVRT----- 702
Query: 822 DPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLY 881
D P PP V+A AL A+RV W S ++ ++R Y
Sbjct: 703 -----------------DEDVPSAPPRKVEAEALNATAIRVLW--RSPAPGRQHGQIRGY 743
Query: 882 TVRWRTSFSASAK--YKSED---TTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAH 936
V + A A+ + +D + T L+P T Y +V + S
Sbjct: 744 QVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 803
Query: 937 ATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPL-EANGKITAYILFYTLDKNIPIDDW 995
T + A P T EG +++ W+PP A ++ Y L + + + P+
Sbjct: 804 VVT-KGAVLGRPTLSVQQTPEG---SLLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT- 858
Query: 996 IMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPIL 1038
+ S DR T ++ Y FR+ AR+ G+G + +L
Sbjct: 859 LEFPPSEDRYT--ASGVHKGATYVFRLAARSRGGLGEEAAEVL 899
Score = 167 bits (423), Expect = 7e-41
Identities = 254/1038 (24%), Positives = 411/1038 (39%), Gaps = 152/1038 (14%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHL-ALGMDERKQQLSNGSLLIQNILH 104
P V R + C+A + P I W KD + + + R +QL +G+L I++
Sbjct: 141 PQLKVVERTRTATMLCAASGNPD-PEITWFKDFLPVDPSASNGRIKQLRSGALQIES--- 196
Query: 105 SRHHKPDEGLYQCEASLGDSGSIISRTAKVAV----AGPLRFLSQTESVTAFMGDTVLLK 160
+ D+G Y+C A+ +G S A + V P RF S G V +
Sbjct: 197 --SEETDQGKYECVAT-NSAGVRYSSPANLYVRVRRVAP-RFSILPMSHEIMPGGNVNIT 252
Query: 161 CEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASS 220
C +G PMP + W + +DLTP +P G + D Y C A +
Sbjct: 253 CVAVGSPMPYVKWMQGAEDLTPEDD------MPVGRNVLELTDVKDSANYTCVAMSSLGV 306
Query: 221 RTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI 280
A++ + S P + + + I SG P P + VI
Sbjct: 307 IEA-VAQITVKSLPKAPGTPMVTENTATSITITWD--------SGNPDPVSYY-----VI 352
Query: 281 QLRSK---------------KYSLLGGS-----NLLISNVTDDDSGMYT-CVVTYKNENI 319
+ +SK +YS+ G S + +S V G + VVT E
Sbjct: 353 EYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA 412
Query: 320 SASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPV--------PTVNWMKNGDVV 371
ASA V L+ + + +E +E + G V P NW K+
Sbjct: 413 PASAPRNVQAR--MLSATTMIVQWEE-PVEPNGLIRGYRVYYTMEPEHPVGNWQKHN--- 466
Query: 372 IPSDYFQIVGGSNLRILGVVKSDEGF-YQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPS 430
V S L +G + DE + + +A G+ S + + + +P
Sbjct: 467 --------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPI-----QVKTQQGVPG 513
Query: 431 APRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVG 490
P ++ S + LSW PP + +I + + F REGD+ T P + V
Sbjct: 514 QPMNLRAEARSETSITLSWSPPRQE--SIIKYELLF-REGDHGREVGRTFDP-TTSYVVE 569
Query: 491 NLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP 550
+LKP Y FR+ A + G G + ++ T + + P ++++ VS T+IL++W P
Sbjct: 570 DLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL-QSKPSAPPQDVKCVSVRSTAILVSWRP 628
Query: 551 PAYA--NGPVQGYRLFCTEVSTGKEQNIEVDGL-----SYKLEGLKKFTEYSLRFLAYNR 603
P NG + GY + + + + EV+G+ LE L+K+T+Y + +A+
Sbjct: 629 PPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTE 688
Query: 604 YGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR 663
GPG + + V T DVPSAPP+ V E +N+ +I+V W P G Q+G I GY++ +
Sbjct: 689 VGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYV 748
Query: 664 K---TTRRGE---METLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPE 717
+ RG + + + + T L+ + YS V+A T+ G G S P+
Sbjct: 749 RMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSK------PK 802
Query: 718 NDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNP-NIVVRGYIIGYGV--GSPYAETVRV 774
+ + V +P+ + ++ W PP V GY + +G +P A T+
Sbjct: 803 VVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLA-TLEF 861
Query: 775 DSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFP 834
+ Y+ + + YV L A + G G E+A SI + T P + +L+
Sbjct: 862 PPSEDRYTASGVHKGATYVFRLAARSRGGLGE---EAAEVLSIPEDT-PRGHPQILEAAG 917
Query: 835 T-SVPDLSTPMLPPVGVQAV-ALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSAS 892
S + LPPV + A+ V V A P + T A+
Sbjct: 918 NASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE-------------TELPAA 964
Query: 893 AKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLT 952
A+ +E+ +L GLKP+T Y+ V R +S T+ S PK+
Sbjct: 965 AEPGAENALTLQ----GLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVS-PKNFK 1019
Query: 953 VITREGKPRAVIVSWQPPLEANGKITAYILFY---TLDKNIPIDDWIMETISGDRLTHQI 1009
V + +V++SW+ P N T Y + Y TLD + G I
Sbjct: 1020 V--KMIMKTSVLLSWEFPDNYNSP-TPYKIQYNGLTLD------------VDGRTTKKLI 1064
Query: 1010 MDLNLDTMYYFRIQARNS 1027
L T Y F + R S
Sbjct: 1065 THLKPHTFYNFVLTNRGS 1082
Score = 51.2 bits (121), Expect = 7e-06
Identities = 81/324 (25%), Positives = 122/324 (37%), Gaps = 44/324 (13%)
Query: 725 VPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYIIGYGVGS---PYAETVRVDSKQRY 780
+P P + V T I ++W NP+ V Y+I Y S PY ++ D
Sbjct: 318 LPKAPGTPMVTENTATSITITWDSG-NPD-PVSYYVIEYKSKSQDGPYQ--IKEDITTTR 373
Query: 781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL 840
YSI L +S Y I + A N+ G+G P ES TR+
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPS-ESVVTRT----------------------GE 410
Query: 841 STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT 900
P P VQA L+ + V W + P YT+ K+ +D
Sbjct: 411 QAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD- 469
Query: 901 TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP 960
SL T L + Y V+ + S T + P P +L R
Sbjct: 470 -SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARS--E 525
Query: 961 RAVIVSWQPPLEANGKITAY-ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYY 1019
++ +SW PP + + I Y +LF D + T S + + DL +T Y
Sbjct: 526 TSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTTS-----YVVEDLKPNTEYA 578
Query: 1020 FRIQARNSKGVGPLSDPILFRTLK 1043
FR+ AR+ +G+G + + RTL+
Sbjct: 579 FRLAARSPQGLGAFTPVVRQRTLQ 602
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 234 bits (598), Expect = 3e-61
Identities = 276/1041 (26%), Positives = 417/1041 (40%), Gaps = 110/1041 (10%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQN 101
F+ P D + GG C A + P I W K G ++ E + +G+ +
Sbjct: 35 FIKVPEDQTGLSGGVASFVCQATGEPK-PRITWMKKGKKVSSQRFE-VIEFDDGAGSVLR 92
Query: 102 ILHSRHHKPDEGLYQCEA--SLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGD---- 155
I R + DE +Y+C A SLG+ I+ +AK++V + S+ MG
Sbjct: 93 IQPLRVQR-DEAIYECTATNSLGE----INTSAKLSVLEEEQLPPGFPSID--MGPQLKV 145
Query: 156 -----TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIY 210
T + C G P P I W K+ + P + R+ L SGALQI + D G Y
Sbjct: 146 VEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY 205
Query: 211 RCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPS 270
C A N A +R A + + R F PS+ + G L C G P P
Sbjct: 206 ECVATNSAGTRYSAPANLYVRVRRVAPR---FSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262
Query: 271 FTWLRGEEVIQLRSKKYSLLGGSNLL-ISNVTDDDSGMYTCVVTYKNENISASAELTVLV 329
W+ G E + +K+ + G N+L +SNV S YTCV I A+A++TV
Sbjct: 263 VKWMMGAEEL---TKEDEMPVGRNVLELSNVVR--SANYTCVAISSLGMIEATAQVTVKA 317
Query: 330 PPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWMKNGDVVIPSDYFQIVGG---SNL 385
P P +L E+ T SG P + FQ V G +
Sbjct: 318 LP---KPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRY 374
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
I G+ E ++ +A N G S + A S PR V ++S+ +
Sbjct: 375 SIGGLSPFSEYAFRVLAVNSIGRGPPSEAV----RARTGEQAPSSPPRRVQARMLSASTM 430
Query: 446 RLSWRPPAEAKGNIQTFTVFF---SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
+ W PP E G ++ + V++ SR N NT L TVG+L P Y+ RV
Sbjct: 431 LVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTD--AGLLTTVGSLLPGITYSLRV 488
Query: 503 VAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYR 562
+A+ G G S I+V TQ VP + QA S T I ++W P + Y
Sbjct: 489 LAFTAVGDGPPSPTIQVKTQQG--VPAQPADFQAEVESDTRIQLSWLLPPQER--IIMYE 544
Query: 563 L-FCTEVSTGKEQNIEVDGLS-YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSD 620
L + ++ + D S Y LE LK T Y + A + G GV T I T
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 621 VPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR----KTTRRGEMETLEP 676
PSAPPQ V + S +++VSW+PPP+ ++NG IT Y + + + R ++ +
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 677 NNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP 736
+ + GLEK ++Y V A T G GP S+ T DE P + V P
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT-----DEDVPSGPPRKVEVEP 719
Query: 737 -QTNCIIMSWTPPL--NPNIVVRGYIIGY-------GVGSPYAETVRVDSKQRYYSIERL 786
+ + + W P+ + +RGY + Y G P + V + Q +I L
Sbjct: 720 LNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQET-TISGL 778
Query: 787 ESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLP 846
+ Y +++ A+ G+G T + +VP T M+
Sbjct: 779 TPETTYSVTVAAYTTKGDGARSKPKIVTTT------------------GAVPGRPTMMIS 820
Query: 847 PVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYT 906
+ L W P + E+ Y +++ + A +T
Sbjct: 821 TTAMNTALL-------QWH----PPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFT 869
Query: 907 ATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVS 966
TGL T Y F + KNR T E P+ P++L V + +
Sbjct: 870 VTGLHKGTTYIFR-LAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTEL--A 926
Query: 967 WQPPL--EANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQA 1024
W PP+ E NG+I +Y + + ++I + + R T + L DT Y +++A
Sbjct: 927 WDPPVLAERNGRIISYTVVF---RDINSQQELQNITTDTRFT--LTGLKPDTTYDIKVRA 981
Query: 1025 RNSKGVGPLSDPILFRTLKVE 1045
SKG GPLS I RT+ VE
Sbjct: 982 WTSKGSGPLSPSIQSRTMPVE 1002
Score = 139 bits (350), Expect = 2e-32
Identities = 173/734 (23%), Positives = 279/734 (38%), Gaps = 86/734 (11%)
Query: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-----GGSNL 385
P F+ P + F C +G+P P + WMK G V S F+++ GS L
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKV-SSQRFEVIEFDDGAGSVL 91
Query: 386 RILGV-VKSDEGFYQCVAENEAGNAQTSAQLIVPK-----PAIPSSSVLPSAPRDVVPVL 439
RI + V+ DE Y+C A N G TSA+L V + P PS + P + V+
Sbjct: 92 RIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQ-----LKVV 146
Query: 440 VSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYT 499
+R + I F F + + + G+LQ+ + Y
Sbjct: 147 EKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY- 205
Query: 500 FRVVAYNEWGPGESSQP---IKVA-TQPELQVPGPVENLQAVSTSPTSILITWEPPAYAN 555
VA N G S+ ++V P +P + + + + + P Y
Sbjct: 206 -ECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVK 264
Query: 556 GPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITV 615
+ L KE + V +L + + Y+ +A + G +T +TV
Sbjct: 265 WMMGAEELT-------KEDEMPVGRNVLELSNVVRSANYTC--VAISSLGMIEATAQVTV 315
Query: 616 VTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE 675
L PP ++ + + S+ ++W SG +T Y I++R G + ++
Sbjct: 316 KALPK----PPIDLVVTETTATSVTLTW---DSGNSEP-VTYYGIQYRAAGTEGPFQEVD 367
Query: 676 P-NNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSS-LH 733
Y GL S+Y+F+V A+ G GPPS A T E Q P P +
Sbjct: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE------QAPSSPPRRVQ 421
Query: 734 VRP-QTNCIIMSWTPPLNPNIVVRGYIIGYGVGS---PYAETVRVDSKQRYYSIERLESS 789
R + +++ W PP PN +VRGY + Y S P A ++ L
Sbjct: 422 ARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPG 481
Query: 790 SHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVG 849
Y + + AF G+G P P P D+
Sbjct: 482 ITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF----------------------- 518
Query: 850 VQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATG 909
QA + +++SW +P ++ L V W + D TS SYT
Sbjct: 519 -QAEVESDTRIQLSWL---LPPQERIIMYEL--VYWAAEDEDQQHKVTFDPTS-SYTLED 571
Query: 910 LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQP 969
LKP+T+Y F + + ++ T A T ++ P++ P+ + ++ V VSW P
Sbjct: 572 LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS--TTVRVSWVP 629
Query: 970 PL--EANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNS 1027
P NG IT Y + Y +++ IS + + ++ L T Y ++A
Sbjct: 630 PPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTD 689
Query: 1028 KGVGPLSDPILFRT 1041
G GP S P+L RT
Sbjct: 690 VGPGPESSPVLVRT 703
Score = 118 bits (295), Expect = 5e-26
Identities = 130/525 (24%), Positives = 214/525 (40%), Gaps = 51/525 (9%)
Query: 352 CTVSGKPVPTVNWM------KNGDVVIPSDYFQIVGG---------------SNLRILGV 390
C G V+W+ +NG + S ++ V G S+ ++G+
Sbjct: 615 CVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGL 674
Query: 391 VKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWR 450
K E A + G S+ ++V V PR V ++S V + W+
Sbjct: 675 EKWTEYRVWVRAHTDVGPGPESSPVLVRT----DEDVPSGPPRKVEVEPLNSTAVHVYWK 730
Query: 451 PPAEAK--GNIQTFTVFFSREGDNRERALNTTQPGSL----QLTVGNLKPEAMYTFRVVA 504
P +K G I+ + V + R + R L Q L + T+ L PE Y+ V A
Sbjct: 731 LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAA 790
Query: 505 YNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLF 564
Y G G S+P V T VPG + +T+ + L+ W PP G + GYRL
Sbjct: 791 YTTKGDGARSKPKIVTTTGA--VPGR-PTMMISTTAMNTALLQWHPPKELPGELLGYRLQ 847
Query: 565 CTEVSTGKEQNIEV--DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVP 622
+ I+ D + + GL K T Y R A NR G G + + T D+P
Sbjct: 848 YCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEK-EIRTPEDLP 906
Query: 623 SAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYL 682
S PQN+ + + + + +++W PP +NG I Y + R + E++ + + + L
Sbjct: 907 SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTL 966
Query: 683 FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII 742
TGL+ + Y +V A T G+GP S + T + QV + + +T+ ++
Sbjct: 967 -TGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRT----MPVEQVFAKNFRVAAAMKTS-VL 1020
Query: 743 MSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNA 802
+SW P + V I+ G ++V VD I L+ ++ Y L ++
Sbjct: 1021 LSWEVPDSYKSAVPFKILYNG------QSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSS 1074
Query: 803 GEGVPLYESATTRSITDPTDPVDYYPLLDD--FPTSVPDLSTPML 845
G+ S T P P+ ++D F S+P + P L
Sbjct: 1075 AGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSL 1119
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 233 bits (594), Expect = 1e-60
Identities = 279/1041 (26%), Positives = 417/1041 (40%), Gaps = 101/1041 (9%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQN 101
F+ P D + GG C A + P I W K G ++ E + +G+ +
Sbjct: 35 FIKVPEDQTGLSGGVASFVCQATGEPK-PRITWMKKGKKVSSQRFE-VIEFDDGAGSVLR 92
Query: 102 ILHSRHHKPDEGLYQCEA--SLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGD---- 155
I R + DE +Y+C A SLG+ I+ +AK++V + S+ MG
Sbjct: 93 IQPLRVQR-DEAIYECTATNSLGE----INTSAKLSVLEEEQLPPGFPSID--MGPQLKV 145
Query: 156 -----TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIY 210
T + C G P P I W K+ + P + R+ L SGALQI + D G Y
Sbjct: 146 VEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY 205
Query: 211 RCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPS 270
C A N A +R A + + R F PS+ + G L C G P P
Sbjct: 206 ECVATNSAGTRYSAPANLYVRVRRVAPR---FSIPPSSQEVMPGGSVNLTCVAVGAPMPY 262
Query: 271 FTWLRGEEVIQLRSKKYSLLGGSNLL-ISNVTDDDSGMYTCVVTYKNENISASAELTVLV 329
W+ G E + +K+ + G N+L +SNV S YTCV I A+A++TV
Sbjct: 263 VKWMMGAEEL---TKEDEMPVGRNVLELSNVVR--SANYTCVAISSLGMIEATAQVTVKA 317
Query: 330 PPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWMKNGDVVIPSDYFQIVGG---SNL 385
P P +L E+ T SG P + FQ V G +
Sbjct: 318 LP---KPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRY 374
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
I G+ E ++ +A N G S + A S PR V ++S+ +
Sbjct: 375 SIGGLSPFSEYAFRVLAVNSIGRGPPSEAV----RARTGEQAPSSPPRRVQARMLSASTM 430
Query: 446 RLSWRPPAEAKGNIQTFTVFF---SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
+ W PP E G ++ + V++ SR N NT L TVG+L P Y+ RV
Sbjct: 431 LVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTD--AGLLTTVGSLLPGITYSLRV 488
Query: 503 VAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYR 562
+A+ G G S I+V TQ VP + QA S T I ++W P + Y
Sbjct: 489 LAFTAVGDGPPSPTIQVKTQQG--VPAQPADFQAEVESDTRIQLSWLLPPQER--IIMYE 544
Query: 563 L-FCTEVSTGKEQNIEVDGLS-YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSD 620
L + ++ + D S Y LE LK T Y + A + G GV T I T
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 621 VPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR----KTTRRGEMETLEP 676
PSAPPQ V + S +++VSW+PPP+ ++NG IT Y + + + R ++ +
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 677 NNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP 736
+ + GLEK ++Y V A T G GP S+ T DE P + V P
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRT-----DEDVPSGPPRKVEVEP 719
Query: 737 -QTNCIIMSWTPPL--NPNIVVRGYIIGY-------GVGSPYAETVRVDSKQRYYSIERL 786
+ + + W P+ + +RGY + Y G P + V + Q R
Sbjct: 720 LNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQW-----RP 774
Query: 787 ESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLP 846
E S Y ++ +G S T + T D P + +VP T M+
Sbjct: 775 EESEDYETTI-----SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMIS 829
Query: 847 PVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYT 906
+ L W P + E+ Y +++ + A +T
Sbjct: 830 TTAMNTALL-------QWH----PPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFT 878
Query: 907 ATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVS 966
TGL T Y F + KNR T E P+ P++L V + +
Sbjct: 879 VTGLHKGTTYIFR-LAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTEL--A 935
Query: 967 WQPPL--EANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQA 1024
W PP+ E NG+I +Y + + ++I + + R T + L DT Y +++A
Sbjct: 936 WDPPVLAERNGRIISYTVVF---RDINSQQELQNITTDTRFT--LTGLKPDTTYDIKVRA 990
Query: 1025 RNSKGVGPLSDPILFRTLKVE 1045
SKG GPLS I RT+ VE
Sbjct: 991 WTSKGSGPLSPSIQSRTMPVE 1011
Score = 139 bits (350), Expect = 2e-32
Identities = 173/734 (23%), Positives = 279/734 (38%), Gaps = 86/734 (11%)
Query: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-----GGSNL 385
P F+ P + F C +G+P P + WMK G V S F+++ GS L
Sbjct: 33 PVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKV-SSQRFEVIEFDDGAGSVL 91
Query: 386 RILGV-VKSDEGFYQCVAENEAGNAQTSAQLIVPK-----PAIPSSSVLPSAPRDVVPVL 439
RI + V+ DE Y+C A N G TSA+L V + P PS + P + V+
Sbjct: 92 RIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQ-----LKVV 146
Query: 440 VSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYT 499
+R + I F F + + + G+LQ+ + Y
Sbjct: 147 EKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY- 205
Query: 500 FRVVAYNEWGPGESSQP---IKVA-TQPELQVPGPVENLQAVSTSPTSILITWEPPAYAN 555
VA N G S+ ++V P +P + + + + + P Y
Sbjct: 206 -ECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVK 264
Query: 556 GPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITV 615
+ L KE + V +L + + Y+ +A + G +T +TV
Sbjct: 265 WMMGAEELT-------KEDEMPVGRNVLELSNVVRSANYTC--VAISSLGMIEATAQVTV 315
Query: 616 VTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE 675
L PP ++ + + S+ ++W SG +T Y I++R G + ++
Sbjct: 316 KALPK----PPIDLVVTETTATSVTLTW---DSGNSEP-VTYYGIQYRAAGTEGPFQEVD 367
Query: 676 P-NNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSS-LH 733
Y GL S+Y+F+V A+ G GPPS A T E Q P P +
Sbjct: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGE------QAPSSPPRRVQ 421
Query: 734 VRP-QTNCIIMSWTPPLNPNIVVRGYIIGYGVGS---PYAETVRVDSKQRYYSIERLESS 789
R + +++ W PP PN +VRGY + Y S P A ++ L
Sbjct: 422 ARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPG 481
Query: 790 SHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVG 849
Y + + AF G+G P P P D+
Sbjct: 482 ITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADF----------------------- 518
Query: 850 VQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATG 909
QA + +++SW +P ++ L V W + D TS SYT
Sbjct: 519 -QAEVESDTRIQLSWL---LPPQERIIMYEL--VYWAAEDEDQQHKVTFDPTS-SYTLED 571
Query: 910 LKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQP 969
LKP+T+Y F + + ++ T A T ++ P++ P+ + ++ V VSW P
Sbjct: 572 LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS--TTVRVSWVP 629
Query: 970 PL--EANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNS 1027
P NG IT Y + Y +++ IS + + ++ L T Y ++A
Sbjct: 630 PPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTD 689
Query: 1028 KGVGPLSDPILFRT 1041
G GP S P+L RT
Sbjct: 690 VGPGPESSPVLVRT 703
Score = 114 bits (286), Expect = 5e-25
Identities = 130/534 (24%), Positives = 214/534 (40%), Gaps = 60/534 (11%)
Query: 352 CTVSGKPVPTVNWM------KNGDVVIPSDYFQIVGG---------------SNLRILGV 390
C G V+W+ +NG + S ++ V G S+ ++G+
Sbjct: 615 CVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGL 674
Query: 391 VKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWR 450
K E A + G S+ ++V V PR V ++S V + W+
Sbjct: 675 EKWTEYRVWVRAHTDVGPGPESSPVLVRT----DEDVPSGPPRKVEVEPLNSTAVHVYWK 730
Query: 451 PPAEAK--GNIQTFTVFFSREGDNRERALNTTQPGSL-------------QLTVGNLKPE 495
P +K G I+ + V + R + R L Q L + T+ L PE
Sbjct: 731 LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPE 790
Query: 496 AMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYAN 555
Y+ V AY G G S+P V T VPG + +T+ + L+ W PP
Sbjct: 791 TTYSVTVAAYTTKGDGARSKPKIVTTTGA--VPGR-PTMMISTTAMNTALLQWHPPKELP 847
Query: 556 GPVQGYRLFCTEVSTGKEQNIEV--DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDI 613
G + GYRL + I+ D + + GL K T Y R A NR G G +
Sbjct: 848 GELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEK- 906
Query: 614 TVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET 673
+ T D+PS PQN+ + + + + +++W PP +NG I Y + R + E++
Sbjct: 907 EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN 966
Query: 674 LEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLH 733
+ + + L TGL+ + Y +V A T G+GP S + T + QV + +
Sbjct: 967 ITTDTRFTL-TGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRT----MPVEQVFAKNFRVA 1021
Query: 734 VRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYV 793
+T+ +++SW P + V I+ G ++V VD I L+ ++ Y
Sbjct: 1022 AAMKTS-VLLSWEVPDSYKSAVPFKILYNG------QSVEVDGHSMRKLIADLQPNTEYS 1074
Query: 794 ISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDD--FPTSVPDLSTPML 845
L ++ G+ S T P P+ ++D F S+P + P L
Sbjct: 1075 FVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSL 1128
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 231 bits (590), Expect = 3e-60
Identities = 208/810 (25%), Positives = 342/810 (42%), Gaps = 74/810 (9%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
S V ++G ++L+C AE P IKW + + D Q N +L + +
Sbjct: 245 SHLVALQGQPLVLECIAEGFP-TPTIKWLRPSGPMPA--DRVTYQNHNKTLQLLKV---- 297
Query: 107 HHKPDEGLYQC--EASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI 164
+ D+G Y+C E SLG + T + A +L + +S G+T L C+V
Sbjct: 298 -GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY----WLHKPQSHLYGPGETARLDCQVQ 352
Query: 165 GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGN 224
G P P + W+ N + + D + + GAL +S +QP D + +C ARN N
Sbjct: 353 GRPQPEVTWRINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLAN 411
Query: 225 EAEVRILSDPGLHRQLYFLQRPSNVV--------AIEGKDAVLECCVSGYPPPSFTWLRG 276
+Y +Q P+ ++ A++G A L C G P PS WL
Sbjct: 412 A-------------YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDE 458
Query: 277 EEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNH 336
+ L+ +++ L I ++ +D+G Y C+ N++ A L V
Sbjct: 459 DGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG 518
Query: 337 PSNLYAYESMDIEFECTVSGKPV--PTVNWMKNG---DVVIPSDYFQIVGGSNLRILGVV 391
P + + + F C S P P++ W +G + SD + I G L I +
Sbjct: 519 PRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG-RLVIHSLD 577
Query: 392 KSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRP 451
SD+G Y CVA E ++ AQL+V + S +P + +L S+ VR+SW P
Sbjct: 578 YSDQGNYSCVASTELDVVESRAQLLV----VGSPGPVPRLVLSDLHLLTQSQ-VRVSWSP 632
Query: 452 PAEAKGNIQTFTVFFSREGDNRERALNTTQ-PGSLQLTVGNLKPEAMYTFRVVAYNEWGP 510
+ I+ + + F + E+ + + PG+ T L P YTFRV A N++GP
Sbjct: 633 AEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGP 692
Query: 511 GESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYA--NGPVQGYRL-FCTE 567
GE S + PE +++ T+++ITW+P + N P YR+ + +
Sbjct: 693 GEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQ 752
Query: 568 VSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQ 627
+ G Q V + F Y ++ A N G G + D P A P+
Sbjct: 753 GTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPE 812
Query: 628 NVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI---------RHRKTTRRGEMETLEPNN 678
+E++NS ++ V W P G + GY + +H K + + N
Sbjct: 813 LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANT 872
Query: 679 LWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT 738
+ +GL S Y +V A G+GP S +T TPE VP P +LH+ Q+
Sbjct: 873 TSVILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEG------VPGHPEALHLECQS 925
Query: 739 N-CIIMSWTPPLNPNIVVRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHY 792
N +++ W PPL+ N V+ GY++ Y G + +R D + R +++ L Y
Sbjct: 926 NTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR-DPELRTHNLTDLSPHLRY 984
Query: 793 VISLKAFNNAGEGVPLYESATTRSITDPTD 822
L+A G G + T +++ +D
Sbjct: 985 RFQLQATTKEGPGEAIVREGGTMALSGISD 1014
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/388 (25%), Positives = 162/388 (41%), Gaps = 24/388 (6%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLA----LGMDERKQQLSNGSLLIQN 101
P V ++ L C A V +W +DG+H LG+ + S + N
Sbjct: 37 PRRLVVFPTDDISLKCEASGKPEVQ-FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGN 95
Query: 102 ILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQT-ESVTAFMGDTVLLK 160
+S + +G+Y+C AS G+ +S ++ G ++ +T + V G++V+L
Sbjct: 96 --NSNFAQRFQGIYRCFAS-NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLP 152
Query: 161 CEVIGEPMPT-IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPA 218
C P I+W ++ + I D RV + +G L + + D Y C A P
Sbjct: 153 CNPPPSAEPLRIYWMNSK--ILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG 210
Query: 219 SSRTGNEAE---VRILSDPGL----HRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF 271
+ RT + E +R+ + + R L+ S++VA++G+ VLEC G+P P+
Sbjct: 211 T-RTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI 269
Query: 272 TWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPP 331
WLR + Y L + V ++D G Y C+ + + +TV P
Sbjct: 270 KWLRPSGPMPADRVTYQ-NHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAP 328
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVV--IPSDYFQIVGGSNLRILG 389
++L+ P + +C V G+P P V W NG V + D + L +
Sbjct: 329 YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSN 388
Query: 390 VVKSDEGFYQCVAENEAGNAQTSAQLIV 417
V SD QC A N G +A + V
Sbjct: 389 VQPSDTMVTQCEARNRHGLLLANAYIYV 416
Score = 68.9 bits (167), Expect = 3e-11
Identities = 102/433 (23%), Positives = 168/433 (38%), Gaps = 85/433 (19%)
Query: 631 LEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGS 690
L ++ ++VSW P+ N I Y I E + + P WY G G+
Sbjct: 618 LHLLTQSQVRVSW--SPAEDHNAPIEKYDIEF-------EDKEMAPEK-WYSL-GKVPGN 666
Query: 691 Q------------YSFQVSAMTVNGTGPPSNWY-TAETPENDLDESQVPDQPSSLHVRPQ 737
Q Y+F+V+A+ G G PS T TPE +++ V + +
Sbjct: 667 QTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEG----NE 722
Query: 738 TNCIIMSWTPPL-----NPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHY 792
T ++++W P P + R G P+ E + D + + + Y
Sbjct: 723 TTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDP---FLVVSNTSTFVPY 779
Query: 793 VISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQA 852
I ++A N+ G+G +P + Y +D+P ++P+L G++
Sbjct: 780 EIKVQAVNSQGKG------------PEPQVTIGYSG--EDYPQAIPELE-------GIEI 818
Query: 853 VALTHDAVRVSWADNSVPKNQKTSEVRLYTVR-WRTSFSA--SAKYKSED-----TTSLS 904
L AV V W V Q +R Y V WR S ++ +D + S
Sbjct: 819 --LNSSAVLVKW--RPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTS 874
Query: 905 YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPR-AV 963
+GL+P + Y V R S S +T P P + E + ++
Sbjct: 875 VILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST-----PEGVPGHPEALHLECQSNTSL 929
Query: 964 IVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETIS-----GDRLTHQIMDLNLDTMY 1018
++ WQPPL NG +T Y+L Y P+D+ +S + TH + DL+ Y
Sbjct: 930 LLRWQPPLSHNGVLTGYVLSYH-----PLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRY 984
Query: 1019 YFRIQARNSKGVG 1031
F++QA +G G
Sbjct: 985 RFQLQATTKEGPG 997
Score = 35.8 bits (81), Expect = 0.31
Identities = 55/230 (23%), Positives = 80/230 (34%), Gaps = 32/230 (13%)
Query: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-----------GEEVIQLRSKKYSLLGG 292
Q P +V D L+C SG P F W R G V Q + G
Sbjct: 35 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 94
Query: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---VPPWFLNHPSNLYAYESMDIE 349
+N SN G+Y C + K + S E+ ++ P W + E +
Sbjct: 95 NN---SNFAQRFQGIYRCFASNK-LGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVV 150
Query: 350 FECTVSGKPVP-TVNWMKNGDVVIPSDYFQIVG-GSNLRILGVVKSD-EGFYQCVAENEA 406
C P + WM + + I D +G NL V+ SD Y C A
Sbjct: 151 LPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH--- 207
Query: 407 GNAQTSAQLIVPKPAI-----PSSSVLPSAPRDVVPVLVSSRFVRLSWRP 451
+ I+ K I ++S++ PR + P SS V L +P
Sbjct: 208 ---FPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQP 254
Score = 32.7 bits (73), Expect = 2.6
Identities = 58/322 (18%), Positives = 114/322 (35%), Gaps = 50/322 (15%)
Query: 730 SSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYG----VGSPYAETVRVDSKQRYYSIER 785
S LH+ Q+ + +SW+P + N + Y I + + +V Q ++ +
Sbjct: 616 SDLHLLTQSQ-VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL-K 673
Query: 786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPML 845
L HY + A N G G P S T + P + P+ + +
Sbjct: 674 LSPYVHYTFRVTAINKYGPGEPSPVSETVVT-----------------PEAAPEKNPVDV 716
Query: 846 PPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSY 905
G + + + W D + P+ Q Y V+WR ++ + +
Sbjct: 717 KGEGNETTNMVITWKPLRWMDWNAPQVQ-------YRVQWRPQ-GTRGPWQEQIVSDPFL 768
Query: 906 TATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPK--DLTVITREGKPRAV 963
+ YE V ++ + E P + P+ + ++ AV
Sbjct: 769 VVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSS----AV 824
Query: 964 IVSWQPP--LEANGKITAYILFYTLD--------KNIPIDDWIMETISGDRLTHQIMDLN 1013
+V W+P + G + Y + Y + ++I D + + + + + L
Sbjct: 825 LVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV---VPANTTSVILSGLR 881
Query: 1014 LDTMYYFRIQARNSKGVGPLSD 1035
+ Y+ +QA N +G GP S+
Sbjct: 882 PYSSYHLEVQAFNGRGSGPASE 903
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 231 bits (590), Expect = 3e-60
Identities = 208/810 (25%), Positives = 342/810 (42%), Gaps = 74/810 (9%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
S V ++G ++L+C AE P IKW + + D Q N +L + +
Sbjct: 250 SHLVALQGQPLVLECIAEGFP-TPTIKWLRPSGPMPA--DRVTYQNHNKTLQLLKV---- 302
Query: 107 HHKPDEGLYQC--EASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI 164
+ D+G Y+C E SLG + T + A +L + +S G+T L C+V
Sbjct: 303 -GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY----WLHKPQSHLYGPGETARLDCQVQ 357
Query: 165 GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGN 224
G P P + W+ N + + D + + GAL +S +QP D + +C ARN N
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLAN 416
Query: 225 EAEVRILSDPGLHRQLYFLQRPSNVV--------AIEGKDAVLECCVSGYPPPSFTWLRG 276
+Y +Q P+ ++ A++G A L C G P PS WL
Sbjct: 417 A-------------YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDE 463
Query: 277 EEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNH 336
+ L+ +++ L I ++ +D+G Y C+ N++ A L V
Sbjct: 464 DGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG 523
Query: 337 PSNLYAYESMDIEFECTVSGKPV--PTVNWMKNG---DVVIPSDYFQIVGGSNLRILGVV 391
P + + + F C S P P++ W +G + SD + I G L I +
Sbjct: 524 PRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG-RLVIHSLD 582
Query: 392 KSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRP 451
SD+G Y CVA E ++ AQL+V + S +P + +L S+ VR+SW P
Sbjct: 583 YSDQGNYSCVASTELDVVESRAQLLV----VGSPGPVPRLVLSDLHLLTQSQ-VRVSWSP 637
Query: 452 PAEAKGNIQTFTVFFSREGDNRERALNTTQ-PGSLQLTVGNLKPEAMYTFRVVAYNEWGP 510
+ I+ + + F + E+ + + PG+ T L P YTFRV A N++GP
Sbjct: 638 AEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGP 697
Query: 511 GESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYA--NGPVQGYRL-FCTE 567
GE S + PE +++ T+++ITW+P + N P YR+ + +
Sbjct: 698 GEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQ 757
Query: 568 VSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQ 627
+ G Q V + F Y ++ A N G G + D P A P+
Sbjct: 758 GTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPE 817
Query: 628 NVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI---------RHRKTTRRGEMETLEPNN 678
+E++NS ++ V W P G + GY + +H K + + N
Sbjct: 818 LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANT 877
Query: 679 LWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT 738
+ +GL S Y +V A G+GP S +T TPE VP P +LH+ Q+
Sbjct: 878 TSVILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEG------VPGHPEALHLECQS 930
Query: 739 N-CIIMSWTPPLNPNIVVRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHY 792
N +++ W PPL+ N V+ GY++ Y G + +R D + R +++ L Y
Sbjct: 931 NTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR-DPELRTHNLTDLSPHLRY 989
Query: 793 VISLKAFNNAGEGVPLYESATTRSITDPTD 822
L+A G G + T +++ +D
Sbjct: 990 RFQLQATTKEGPGEAIVREGGTMALSGISD 1019
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/388 (25%), Positives = 162/388 (41%), Gaps = 24/388 (6%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLA----LGMDERKQQLSNGSLLIQN 101
P V ++ L C A V +W +DG+H LG+ + S + N
Sbjct: 42 PRRLVVFPTDDISLKCEASGKPEVQ-FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGN 100
Query: 102 ILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQT-ESVTAFMGDTVLLK 160
+S + +G+Y+C AS G+ +S ++ G ++ +T + V G++V+L
Sbjct: 101 --NSNFAQRFQGIYRCFAS-NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLP 157
Query: 161 CEVIGEPMPT-IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPA 218
C P I+W ++ + I D RV + +G L + + D Y C A P
Sbjct: 158 CNPPPSAEPLRIYWMNSK--ILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG 215
Query: 219 SSRTGNEAE---VRILSDPGL----HRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF 271
+ RT + E +R+ + + R L+ S++VA++G+ VLEC G+P P+
Sbjct: 216 T-RTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI 274
Query: 272 TWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPP 331
WLR + Y L + V ++D G Y C+ + + +TV P
Sbjct: 275 KWLRPSGPMPADRVTYQ-NHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAP 333
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVV--IPSDYFQIVGGSNLRILG 389
++L+ P + +C V G+P P V W NG V + D + L +
Sbjct: 334 YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSN 393
Query: 390 VVKSDEGFYQCVAENEAGNAQTSAQLIV 417
V SD QC A N G +A + V
Sbjct: 394 VQPSDTMVTQCEARNRHGLLLANAYIYV 421
Score = 68.9 bits (167), Expect = 3e-11
Identities = 102/433 (23%), Positives = 168/433 (38%), Gaps = 85/433 (19%)
Query: 631 LEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGS 690
L ++ ++VSW P+ N I Y I E + + P WY G G+
Sbjct: 623 LHLLTQSQVRVSW--SPAEDHNAPIEKYDIEF-------EDKEMAPEK-WYSL-GKVPGN 671
Query: 691 Q------------YSFQVSAMTVNGTGPPSNWY-TAETPENDLDESQVPDQPSSLHVRPQ 737
Q Y+F+V+A+ G G PS T TPE +++ V + +
Sbjct: 672 QTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEG----NE 727
Query: 738 TNCIIMSWTPPL-----NPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHY 792
T ++++W P P + R G P+ E + D + + + Y
Sbjct: 728 TTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDP---FLVVSNTSTFVPY 784
Query: 793 VISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQA 852
I ++A N+ G+G +P + Y +D+P ++P+L G++
Sbjct: 785 EIKVQAVNSQGKG------------PEPQVTIGYSG--EDYPQAIPELE-------GIEI 823
Query: 853 VALTHDAVRVSWADNSVPKNQKTSEVRLYTVR-WRTSFSA--SAKYKSED-----TTSLS 904
L AV V W V Q +R Y V WR S ++ +D + S
Sbjct: 824 --LNSSAVLVKW--RPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTS 879
Query: 905 YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPR-AV 963
+GL+P + Y V R S S +T P P + E + ++
Sbjct: 880 VILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST-----PEGVPGHPEALHLECQSNTSL 934
Query: 964 IVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETIS-----GDRLTHQIMDLNLDTMY 1018
++ WQPPL NG +T Y+L Y P+D+ +S + TH + DL+ Y
Sbjct: 935 LLRWQPPLSHNGVLTGYVLSYH-----PLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRY 989
Query: 1019 YFRIQARNSKGVG 1031
F++QA +G G
Sbjct: 990 RFQLQATTKEGPG 1002
Score = 35.8 bits (81), Expect = 0.31
Identities = 55/230 (23%), Positives = 80/230 (34%), Gaps = 32/230 (13%)
Query: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-----------GEEVIQLRSKKYSLLGG 292
Q P +V D L+C SG P F W R G V Q + G
Sbjct: 40 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99
Query: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---VPPWFLNHPSNLYAYESMDIE 349
+N SN G+Y C + K + S E+ ++ P W + E +
Sbjct: 100 NN---SNFAQRFQGIYRCFASNK-LGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVV 155
Query: 350 FECTVSGKPVP-TVNWMKNGDVVIPSDYFQIVG-GSNLRILGVVKSD-EGFYQCVAENEA 406
C P + WM + + I D +G NL V+ SD Y C A
Sbjct: 156 LPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH--- 212
Query: 407 GNAQTSAQLIVPKPAI-----PSSSVLPSAPRDVVPVLVSSRFVRLSWRP 451
+ I+ K I ++S++ PR + P SS V L +P
Sbjct: 213 ---FPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQP 259
Score = 32.7 bits (73), Expect = 2.6
Identities = 58/322 (18%), Positives = 114/322 (35%), Gaps = 50/322 (15%)
Query: 730 SSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYG----VGSPYAETVRVDSKQRYYSIER 785
S LH+ Q+ + +SW+P + N + Y I + + +V Q ++ +
Sbjct: 621 SDLHLLTQSQ-VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL-K 678
Query: 786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPML 845
L HY + A N G G P S T + P + P+ + +
Sbjct: 679 LSPYVHYTFRVTAINKYGPGEPSPVSETVVT-----------------PEAAPEKNPVDV 721
Query: 846 PPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSY 905
G + + + W D + P+ Q Y V+WR ++ + +
Sbjct: 722 KGEGNETTNMVITWKPLRWMDWNAPQVQ-------YRVQWRPQ-GTRGPWQEQIVSDPFL 773
Query: 906 TATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPK--DLTVITREGKPRAV 963
+ YE V ++ + E P + P+ + ++ AV
Sbjct: 774 VVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSS----AV 829
Query: 964 IVSWQPP--LEANGKITAYILFYTLD--------KNIPIDDWIMETISGDRLTHQIMDLN 1013
+V W+P + G + Y + Y + ++I D + + + + + L
Sbjct: 830 LVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV---VPANTTSVILSGLR 886
Query: 1014 LDTMYYFRIQARNSKGVGPLSD 1035
+ Y+ +QA N +G GP S+
Sbjct: 887 PYSSYHLEVQAFNGRGSGPASE 908
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 231 bits (590), Expect = 3e-60
Identities = 208/810 (25%), Positives = 342/810 (42%), Gaps = 74/810 (9%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
S V ++G ++L+C AE P IKW + + D Q N +L + +
Sbjct: 250 SHLVALQGQPLVLECIAEGFP-TPTIKWLRPSGPMPA--DRVTYQNHNKTLQLLKV---- 302
Query: 107 HHKPDEGLYQC--EASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI 164
+ D+G Y+C E SLG + T + A +L + +S G+T L C+V
Sbjct: 303 -GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY----WLHKPQSHLYGPGETARLDCQVQ 357
Query: 165 GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGN 224
G P P + W+ N + + D + + GAL +S +QP D + +C ARN N
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVTQCEARNRHGLLLAN 416
Query: 225 EAEVRILSDPGLHRQLYFLQRPSNVV--------AIEGKDAVLECCVSGYPPPSFTWLRG 276
+Y +Q P+ ++ A++G A L C G P PS WL
Sbjct: 417 A-------------YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDE 463
Query: 277 EEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNH 336
+ L+ +++ L I ++ +D+G Y C+ N++ A L V
Sbjct: 464 DGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQG 523
Query: 337 PSNLYAYESMDIEFECTVSGKPV--PTVNWMKNG---DVVIPSDYFQIVGGSNLRILGVV 391
P + + + F C S P P++ W +G + SD + I G L I +
Sbjct: 524 PRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG-RLVIHSLD 582
Query: 392 KSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRP 451
SD+G Y CVA E ++ AQL+V + S +P + +L S+ VR+SW P
Sbjct: 583 YSDQGNYSCVASTELDVVESRAQLLV----VGSPGPVPRLVLSDLHLLTQSQ-VRVSWSP 637
Query: 452 PAEAKGNIQTFTVFFSREGDNRERALNTTQ-PGSLQLTVGNLKPEAMYTFRVVAYNEWGP 510
+ I+ + + F + E+ + + PG+ T L P YTFRV A N++GP
Sbjct: 638 AEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGP 697
Query: 511 GESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYA--NGPVQGYRL-FCTE 567
GE S + PE +++ T+++ITW+P + N P YR+ + +
Sbjct: 698 GEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQ 757
Query: 568 VSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQ 627
+ G Q V + F Y ++ A N G G + D P A P+
Sbjct: 758 GTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPE 817
Query: 628 NVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI---------RHRKTTRRGEMETLEPNN 678
+E++NS ++ V W P G + GY + +H K + + N
Sbjct: 818 LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANT 877
Query: 679 LWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQT 738
+ +GL S Y +V A G+GP S +T TPE VP P +LH+ Q+
Sbjct: 878 TSVILSGLRPYSSYHLEVQAFNGRGSGPASE-FTFSTPEG------VPGHPEALHLECQS 930
Query: 739 N-CIIMSWTPPLNPNIVVRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHY 792
N +++ W PPL+ N V+ GY++ Y G + +R D + R +++ L Y
Sbjct: 931 NTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLR-DPELRTHNLTDLSPHLRY 989
Query: 793 VISLKAFNNAGEGVPLYESATTRSITDPTD 822
L+A G G + T +++ +D
Sbjct: 990 RFQLQATTKEGPGEAIVREGGTMALSGISD 1019
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/388 (25%), Positives = 162/388 (41%), Gaps = 24/388 (6%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLA----LGMDERKQQLSNGSLLIQN 101
P V ++ L C A V +W +DG+H LG+ + S + N
Sbjct: 42 PRRLVVFPTDDISLKCEASGKPEVQ-FRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGN 100
Query: 102 ILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQT-ESVTAFMGDTVLLK 160
+S + +G+Y+C AS G+ +S ++ G ++ +T + V G++V+L
Sbjct: 101 --NSNFAQRFQGIYRCFAS-NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLP 157
Query: 161 CEVIGEPMPT-IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPA 218
C P I+W ++ + I D RV + +G L + + D Y C A P
Sbjct: 158 CNPPPSAEPLRIYWMNSK--ILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPG 215
Query: 219 SSRTGNEAE---VRILSDPGL----HRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSF 271
+ RT + E +R+ + + R L+ S++VA++G+ VLEC G+P P+
Sbjct: 216 T-RTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI 274
Query: 272 TWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPP 331
WLR + Y L + V ++D G Y C+ + + +TV P
Sbjct: 275 KWLRPSGPMPADRVTYQ-NHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAP 333
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVV--IPSDYFQIVGGSNLRILG 389
++L+ P + +C V G+P P V W NG V + D + L +
Sbjct: 334 YWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSN 393
Query: 390 VVKSDEGFYQCVAENEAGNAQTSAQLIV 417
V SD QC A N G +A + V
Sbjct: 394 VQPSDTMVTQCEARNRHGLLLANAYIYV 421
Score = 68.9 bits (167), Expect = 3e-11
Identities = 102/433 (23%), Positives = 168/433 (38%), Gaps = 85/433 (19%)
Query: 631 LEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGS 690
L ++ ++VSW P+ N I Y I E + + P WY G G+
Sbjct: 623 LHLLTQSQVRVSW--SPAEDHNAPIEKYDIEF-------EDKEMAPEK-WYSL-GKVPGN 671
Query: 691 Q------------YSFQVSAMTVNGTGPPSNWY-TAETPENDLDESQVPDQPSSLHVRPQ 737
Q Y+F+V+A+ G G PS T TPE +++ V + +
Sbjct: 672 QTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEG----NE 727
Query: 738 TNCIIMSWTPPL-----NPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHY 792
T ++++W P P + R G P+ E + D + + + Y
Sbjct: 728 TTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDP---FLVVSNTSTFVPY 784
Query: 793 VISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQA 852
I ++A N+ G+G +P + Y +D+P ++P+L G++
Sbjct: 785 EIKVQAVNSQGKG------------PEPQVTIGYSG--EDYPQAIPELE-------GIEI 823
Query: 853 VALTHDAVRVSWADNSVPKNQKTSEVRLYTVR-WRTSFSA--SAKYKSED-----TTSLS 904
L AV V W V Q +R Y V WR S ++ +D + S
Sbjct: 824 --LNSSAVLVKW--RPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTS 879
Query: 905 YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPR-AV 963
+GL+P + Y V R S S +T P P + E + ++
Sbjct: 880 VILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST-----PEGVPGHPEALHLECQSNTSL 934
Query: 964 IVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETIS-----GDRLTHQIMDLNLDTMY 1018
++ WQPPL NG +T Y+L Y P+D+ +S + TH + DL+ Y
Sbjct: 935 LLRWQPPLSHNGVLTGYVLSYH-----PLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRY 989
Query: 1019 YFRIQARNSKGVG 1031
F++QA +G G
Sbjct: 990 RFQLQATTKEGPG 1002
Score = 35.8 bits (81), Expect = 0.31
Identities = 55/230 (23%), Positives = 80/230 (34%), Gaps = 32/230 (13%)
Query: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-----------GEEVIQLRSKKYSLLGG 292
Q P +V D L+C SG P F W R G V Q + G
Sbjct: 40 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99
Query: 293 SNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---VPPWFLNHPSNLYAYESMDIE 349
+N SN G+Y C + K + S E+ ++ P W + E +
Sbjct: 100 NN---SNFAQRFQGIYRCFASNK-LGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVV 155
Query: 350 FECTVSGKPVP-TVNWMKNGDVVIPSDYFQIVG-GSNLRILGVVKSD-EGFYQCVAENEA 406
C P + WM + + I D +G NL V+ SD Y C A
Sbjct: 156 LPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH--- 212
Query: 407 GNAQTSAQLIVPKPAI-----PSSSVLPSAPRDVVPVLVSSRFVRLSWRP 451
+ I+ K I ++S++ PR + P SS V L +P
Sbjct: 213 ---FPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQP 259
Score = 32.7 bits (73), Expect = 2.6
Identities = 58/322 (18%), Positives = 114/322 (35%), Gaps = 50/322 (15%)
Query: 730 SSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYG----VGSPYAETVRVDSKQRYYSIER 785
S LH+ Q+ + +SW+P + N + Y I + + +V Q ++ +
Sbjct: 621 SDLHLLTQSQ-VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL-K 678
Query: 786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPML 845
L HY + A N G G P S T + P + P+ + +
Sbjct: 679 LSPYVHYTFRVTAINKYGPGEPSPVSETVVT-----------------PEAAPEKNPVDV 721
Query: 846 PPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSY 905
G + + + W D + P+ Q Y V+WR ++ + +
Sbjct: 722 KGEGNETTNMVITWKPLRWMDWNAPQVQ-------YRVQWRPQ-GTRGPWQEQIVSDPFL 773
Query: 906 TATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPK--DLTVITREGKPRAV 963
+ YE V ++ + E P + P+ + ++ AV
Sbjct: 774 VVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSS----AV 829
Query: 964 IVSWQPP--LEANGKITAYILFYTLD--------KNIPIDDWIMETISGDRLTHQIMDLN 1013
+V W+P + G + Y + Y + ++I D + + + + + L
Sbjct: 830 LVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVV---VPANTTSVILSGLR 886
Query: 1014 LDTMYYFRIQARNSKGVGPLSD 1035
+ Y+ +QA N +G GP S+
Sbjct: 887 PYSSYHLEVQAFNGRGSGPASE 908
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 225 bits (574), Expect = 2e-58
Identities = 279/1067 (26%), Positives = 419/1067 (39%), Gaps = 137/1067 (12%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ--QLSNGSLL 98
RF+ EP D + + GG C A D P + W K G + E + + + L
Sbjct: 34 RFIKEPKDQIGVSGGVASFVCQATGDPK-PRVTWNKKGKKVNSQRFETIEFDESAGAVLR 92
Query: 99 IQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAF----MG 154
IQ + R DE +Y+C A + ++ V L L + + + F MG
Sbjct: 93 IQPLRTPR----DENVYECVAQ--------NSVGEITVHAKLTVLREDQLPSGFPNIDMG 140
Query: 155 D---------TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPS---------GA 196
T + C G P P I W K+ + P + R+ L S GA
Sbjct: 141 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA 200
Query: 197 LQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL-YFLQRPSNVVAIEGK 255
LQI + D G Y C A N A R + A + + + R F P + + G
Sbjct: 201 LQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGG 260
Query: 256 DAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTD-DDSGMYTCVVTY 314
+ + C G P P W++G E + + + + G N+L +TD DS YTCV
Sbjct: 261 NVNITCVAVGSPMPYVKWMQGAEDL---TPEDDMPVGRNVL--ELTDVKDSANYTCVAMS 315
Query: 315 KNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTV-SGKPVPTVNWM---KNGDV 370
I A A++TV P P E+ T SG P P ++ K+
Sbjct: 316 SLGVIEAVAQITVKSLP---KAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQ 372
Query: 371 VIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPS 430
P + + + I G+ + E A N G S ++ S
Sbjct: 373 DGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRT----GEQAPAS 428
Query: 431 APRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQP----GSLQ 486
APR+V ++S+ + + W P E G I+ + V+++ E E + Q SL
Sbjct: 429 APRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEP---EHPVGNWQKHNVDDSLL 485
Query: 487 LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILI 546
TVG+L + YT RV+A+ G G S PI+V TQ VPG NL+A + S TSI +
Sbjct: 486 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG--VPGQPMNLRAEARSETSITL 543
Query: 547 TWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGL-SYKLEGLKKFTEYSLRFLAYNRYG 605
+W PP + + Y L E G+E D SY +E LK TEY+ R A + G
Sbjct: 544 SWSPPRQES--IIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQG 601
Query: 606 PGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHR-- 663
G T + TL PSAPPQ+V V S +I VSW PPP T NG + GY +R+R
Sbjct: 602 LGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 661
Query: 664 --KTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLD 721
+ E+ + P L LEK +QY A T G GP S+ T E D
Sbjct: 662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDE---D 718
Query: 722 ESQVPDQPSSLHVRPQTNCIIMSWTP-PLNPNIVVRGYIIGY-------GVGSPYAETVR 773
P + T ++ +P P + +RGY + Y G P + V
Sbjct: 719 VPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVM 778
Query: 774 V--------DSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVD 825
+ D+ + I L+ + Y I++ A+ G+G + + P V
Sbjct: 779 LADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDG----------ARSKPKVVVT 828
Query: 826 YYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRW 885
+L P LS P ++ W + + RL R
Sbjct: 829 KGAVL-----GRPTLSVQQTP----------EGSLLARWEPPAGTAEDQVLGYRLQFGRE 873
Query: 886 RTSFSASAKY-KSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
++ A+ ++ SED YTA+G+ Y F + ++R + E P
Sbjct: 874 DSTPLATLEFPPSED----RYTASGVHKGATYVFR-LAARSRGGLGEEAAEVLSIPEDTP 928
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPL--EANGKITAY--------ILFYTLDKNIPIDD 994
P+ L V++ W PP+ E NG I Y L + +P
Sbjct: 929 RGHPQILEA-AGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPA-- 985
Query: 995 WIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
E + + LT + L DT Y +++A +G GP S P+ +RT
Sbjct: 986 -AAEPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRT 1029
Score = 203 bits (516), Expect = 1e-51
Identities = 237/965 (24%), Positives = 379/965 (39%), Gaps = 132/965 (13%)
Query: 135 AVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQK-----NQQDLTPIPGDSRV 189
A P RF+ + + G C+ G+P P + W K N Q I D
Sbjct: 28 AAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESA 87
Query: 190 VVLPSGALQISRLQ-PGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSN 248
L+I L+ P D +Y C A+N T + A++ +L + L +
Sbjct: 88 ----GAVLRIQPLRTPRDENVYECVAQNSVGEITVH-AKLTVLREDQLPSGFPNIDMGPQ 142
Query: 249 VVAIE-GKDAVLECCVSGYPPPSFTWLR----------GEEVIQLRSKKY-SLLGGSNLL 296
+ +E + A + C SG P P TW + + QLRS+ + S L
Sbjct: 143 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQ 202
Query: 297 ISNVTDDDSGMYTCVVTYK-NENISASAELTV-------LVPPWFLNHPSNLYAYESMDI 348
I + + D G Y CV T S+ A L V V P F P + ++
Sbjct: 203 IESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNV 262
Query: 349 EFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGN 408
C G P+P V WM+ + + P D + G N+ L VK D Y CVA + G
Sbjct: 263 NITCVAVGSPMPYVKWMQGAEDLTPEDDMPV--GRNVLELTDVK-DSANYTCVAMSSLGV 319
Query: 409 AQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFF-- 466
+ AQ+ V LP AP + ++ + ++W GN + +
Sbjct: 320 IEAVAQITVKS--------LPKAPGTPMVTENTATSITITW-----DSGNPDPVSYYVIE 366
Query: 467 ----SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ 522
S++G + + TT + ++G L P + Y V A N G G S+ + T
Sbjct: 367 YKSKSQDGPYQIKEDITT----TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTG 422
Query: 523 PELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCT-----EVSTGKEQNIE 577
+ P N+QA S T++++ WE P NG ++GYR++ T V ++ N++
Sbjct: 423 EQAPASAP-RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVD 481
Query: 578 VDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
D L + L + Y++R LA+ G G +D I V T VP P N+ E +
Sbjct: 482 -DSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSET 539
Query: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEM-ETLEPNNLWYLFTGLEKGSQYSFQV 696
SI +SW PP + I Y++ R+ E+ T +P Y+ L+ ++Y+F++
Sbjct: 540 SITLSWSPP----RQESIIKYELLFREGDHGREVGRTFDPTTS-YVVEDLKPNTEYAFRL 594
Query: 697 SAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVR 756
+A + G G +T + L V ++ I++SW PP P
Sbjct: 595 AARSPQGLGA----FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPP--PPETHN 648
Query: 757 GYIIGYGV-----GSPYAETVRVDS---KQRYYSIERLESSSHYVISLKAFNNAGEGVPL 808
G ++GY V GS E V+ +E LE + Y I+ A G G P
Sbjct: 649 GALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG-PE 707
Query: 809 YESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNS 868
R+ D P PP V+A AL A+RV W S
Sbjct: 708 SSPVVVRT----------------------DEDVPSAPPRKVEAEALNATAIRVLW--RS 743
Query: 869 VPKNQKTSEVRLYTV--------------RWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
++ ++R Y V R + A A+++++DT T L+P T
Sbjct: 744 PAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPET 803
Query: 915 MYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPL-EA 973
Y +V + S T + A P T EG +++ W+PP A
Sbjct: 804 AYSITVAAYTMKGDGARSKPKVVVT-KGAVLGRPTLSVQQTPEG---SLLARWEPPAGTA 859
Query: 974 NGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPL 1033
++ Y L + + + P+ + S DR T ++ Y FR+ AR+ G+G
Sbjct: 860 EDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYT--ASGVHKGATYVFRLAARSRGGLGEE 916
Query: 1034 SDPIL 1038
+ +L
Sbjct: 917 AAEVL 921
Score = 158 bits (400), Expect = 3e-38
Identities = 256/1060 (24%), Positives = 412/1060 (38%), Gaps = 174/1060 (16%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHL-ALGMDERKQQLSN---------G 95
P V R + C+A + P I W KD + + + R +QL + G
Sbjct: 141 PQLKVVERTRTATMLCAASGNPD-PEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRG 199
Query: 96 SLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAV--------AGPLRFLSQTE 147
+L I++ + D+G Y+C A+ +G S A + V P RF
Sbjct: 200 ALQIES-----SEETDQGKYECVAT-NSAGVRYSSPANLYVRELREVRRVAP-RFSILPM 252
Query: 148 SVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI 207
S G V + C +G PMP + W + +DLTP +P G + D
Sbjct: 253 SHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDD------MPVGRNVLELTDVKDS 306
Query: 208 GIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYP 267
Y C A + A++ + S P + + + I SG P
Sbjct: 307 ANYTCVAMSSLGVIEA-VAQITVKSLPKAPGTPMVTENTATSITITWD--------SGNP 357
Query: 268 PPSFTWLRGEEVIQLRSK---------------KYSLLGGS-----NLLISNVTDDDSGM 307
P + VI+ +SK +YS+ G S + +S V G
Sbjct: 358 DPVSYY-----VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGP 412
Query: 308 YT-CVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPV------- 359
+ VVT E ASA V L+ + + +E +E + G V
Sbjct: 413 PSESVVTRTGEQAPASAPRNVQAR--MLSATTMIVQWEE-PVEPNGLIRGYRVYYTMEPE 469
Query: 360 -PTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGF-YQCVAENEAGNAQTSAQLIV 417
P NW K+ V S L +G + DE + + +A G+ S +
Sbjct: 470 HPVGNWQKHN-----------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPI-- 516
Query: 418 PKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERAL 477
+ + +P P ++ S + LSW PP + +I + + F REGD+
Sbjct: 517 ---QVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQE--SIIKYELLF-REGDHGREVG 570
Query: 478 NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAV 537
T P + V +LKP Y FR+ A + G G + ++ T + + P ++++ V
Sbjct: 571 RTFDP-TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL-QSKPSAPPQDVKCV 628
Query: 538 STSPTSILITWEPPAYA--NGPVQGYRLFCTEVSTGKEQNIEVDGL-----SYKLEGLKK 590
S T+IL++W PP NG + GY + + + + EV+G+ LE L+K
Sbjct: 629 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 688
Query: 591 FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
+T+Y + +A+ GPG + + V T DVPSAPP+ V E +N+ +I+V W P G
Sbjct: 689 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 748
Query: 651 QNGFITGYKIRHRK---TTRRG------------EMETLEPNNLWYLFTGLEKGSQYSFQ 695
Q+G I GY++ + + RG + ET + + T L+ + YS
Sbjct: 749 QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSIT 808
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNP-NIV 754
V+A T+ G G S P+ + + V +P+ + ++ W PP
Sbjct: 809 VAAYTMKGDGARSK------PKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQ 862
Query: 755 VRGYIIGYGV--GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESA 812
V GY + +G +P A T+ + Y+ + + YV L A + G G E+A
Sbjct: 863 VLGYRLQFGREDSTPLA-TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE---EAA 918
Query: 813 TTRSITDPTDPVDYYPLLDDFPT-SVPDLSTPMLPPVGVQAV-ALTHDAVRVSWADNSVP 870
SI + T P + +L+ S + LPPV + A+ V V A P
Sbjct: 919 EVLSIPEDT-PRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGP 977
Query: 871 KNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSST 930
+ T A+A+ +E+ +L GLKP+T Y+ V R
Sbjct: 978 ARE-------------TELPAAAEPGAENALTLQ----GLKPDTAYDLQVRAHTRRGPGP 1020
Query: 931 WSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFY---TLD 987
+S T+ S PK+ V + +V++SW+ P N T Y + Y TLD
Sbjct: 1021 FSPPVRYRTFLRDQVS-PKNFKV--KMIMKTSVLLSWEFPDNYNSP-TPYKIQYNGLTLD 1076
Query: 988 KNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNS 1027
+ G I L T Y F + R S
Sbjct: 1077 ------------VDGRTTKKLITHLKPHTFYNFVLTNRGS 1104
Score = 51.2 bits (121), Expect = 7e-06
Identities = 81/324 (25%), Positives = 122/324 (37%), Gaps = 44/324 (13%)
Query: 725 VPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYIIGYGVGS---PYAETVRVDSKQRY 780
+P P + V T I ++W NP+ V Y+I Y S PY ++ D
Sbjct: 331 LPKAPGTPMVTENTATSITITWDSG-NPD-PVSYYVIEYKSKSQDGPYQ--IKEDITTTR 386
Query: 781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL 840
YSI L +S Y I + A N+ G+G P ES TR+
Sbjct: 387 YSIGGLSPNSEYEIWVSAVNSIGQGPPS-ESVVTRT----------------------GE 423
Query: 841 STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT 900
P P VQA L+ + V W + P YT+ K+ +D
Sbjct: 424 QAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD- 482
Query: 901 TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP 960
SL T L + Y V+ + S T + P P +L R
Sbjct: 483 -SLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARS--E 538
Query: 961 RAVIVSWQPPLEANGKITAY-ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYY 1019
++ +SW PP + + I Y +LF D + T S + + DL +T Y
Sbjct: 539 TSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTTS-----YVVEDLKPNTEYA 591
Query: 1020 FRIQARNSKGVGPLSDPILFRTLK 1043
FR+ AR+ +G+G + + RTL+
Sbjct: 592 FRLAARSPQGLGAFTPVVRQRTLQ 615
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 225 bits (574), Expect = 2e-58
Identities = 214/802 (26%), Positives = 336/802 (41%), Gaps = 72/802 (8%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
S ++G +LL+C AE P + W K G L G + ++ +L I+N+ +
Sbjct: 264 SSITILKGEILLLECFAEG-LPTPQVDWNKIGGDLPKGRETKENY--GKTLKIENVSYQ- 319
Query: 107 HHKPDEGLYQCEAS--LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI 164
D+G Y+C AS LG + + V V P R+ + +S G +L CE
Sbjct: 320 ----DKGNYRCTASNFLGTA----THDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAE 371
Query: 165 GEPMPTIHWQKNQQ--DLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRT 222
GEP PTI W+ N D P GD VV P + + LQP +Y+C A N +
Sbjct: 372 GEPQPTIKWRVNGSPVDNHPFAGD---VVFPR-EISFTNLQPNHTAVYQCEASNVHGTIL 427
Query: 223 GNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQL 282
N A + ++ R L + N + G A L C P +W + EEV L
Sbjct: 428 AN-ANIDVVDV----RPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPL 482
Query: 283 RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSN--- 339
++Y + L I+ T++D+G Y+C V + +A L + P N
Sbjct: 483 EGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRI 542
Query: 340 --LYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI---PSDYFQIVGGSNLRILGVVKSD 394
L+ E + E +C K ++W K+G+ D I+ G+NL I V D
Sbjct: 543 PKLHMLE-LHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLED 601
Query: 395 EGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAE 454
+G Y C A +A Q+ V +P P ++ +R VRL+W A+
Sbjct: 602 QGIYCCSAHTALDSAADITQVTVLD--------VPDPPENLHLSERQNRSVRLTWEAGAD 653
Query: 455 AKGNIQTFTVFF--SREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGE 512
NI + V F ++E R L Q G + L P Y FRV+A NE G +
Sbjct: 654 HNSNISEYIVEFEGNKEEPGRWEELTRVQ-GKKTTVILPLAPFVRYQFRVIAVNEVGRSQ 712
Query: 513 SSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCTEVST 570
SQP P +N++ ++ P ++I WEP NGP YR+
Sbjct: 713 PSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGA 772
Query: 571 GKEQNIE-VDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
E E V + ++ + Y ++ A N+ G G +T+ + D P P
Sbjct: 773 PVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIH 832
Query: 630 SLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTR--RGEMETLEPNNLWY------ 681
++V+NS +KV+W P +G + GY+I KT G E N L +
Sbjct: 833 GVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNS 892
Query: 682 -LFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHV-RPQTN 739
+ L+ S++ V A G GP S Y +TPE VP+QP+ L V + +
Sbjct: 893 GMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEG------VPEQPTFLKVIKVDKD 946
Query: 740 CIIMSWTPPLNPNIVVRGYIIGYGVGSPYAE-------TVRVDSKQRYYSIERLESSSHY 792
+SW P N + GY++ Y + + E + SK ++ + L +++ Y
Sbjct: 947 TATLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWH-LSNLNATTKY 1005
Query: 793 VISLKAFNNAGEGVPLYESATT 814
L+A + G G P+ E ++T
Sbjct: 1006 KFYLRACTSQGCGKPITEESST 1027
Score = 121 bits (304), Expect = 4e-27
Identities = 165/704 (23%), Positives = 278/704 (39%), Gaps = 68/704 (9%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ 100
R+ +P AV G N +L C AE + P IKW+ +G + + + +
Sbjct: 348 RWTKKPQSAVYSTGSNGILLCEAEGE-PQPTIKWRVNGSPV------DNHPFAGDVVFPR 400
Query: 101 NILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK 160
I + +YQCEAS + + V PL E+ +G + L
Sbjct: 401 EISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLH 460
Query: 161 CEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASS 220
CE P + WQK +++ P+ G R + +G LQI+R D G Y C N A
Sbjct: 461 CEFFASPEAVVSWQK-VEEVKPLEG-RRYHIYENGTLQINRTTEEDAGSYSCWVEN-AIG 517
Query: 221 RTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEC---CVSGYPPP-SFTWLRG 276
+T A + I + L P N + L C C S +W +
Sbjct: 518 KTAVTANLDIRNATKLR------VSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD 571
Query: 277 EEVIQLRSKKYS--LLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
E ++ + ++ G+NL ISNVT +D G+Y C ++ + ++TVL P
Sbjct: 572 GEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVP--- 628
Query: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMK-----NGDVVIP---SDYFQIVGGSNLR 386
+ P NL+ E + T N + G+ P + ++ G
Sbjct: 629 DPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTV 688
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTS--AQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRF 444
IL + ++ +A NE G +Q S + PA P + P+++ +
Sbjct: 689 ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRN-----PQNIRVQASQPKE 743
Query: 445 VRLSWRP--PAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
+ + W P E G + V + +G E T +L++ + A Y +V
Sbjct: 744 MIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAV--YAPYDVKV 801
Query: 503 VAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWE--PPAYANGPVQG 560
A N+ G G Q + + + + PV + V S T + +TW P +G ++G
Sbjct: 802 QAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINS-TLVKVTWSTVPKDRVHGRLKG 860
Query: 561 YRLFCTEVST---GKEQNIEVDGLSYK-------LEGLKKFTEYSLRFLAYNRYGPGVST 610
Y++ + + G+ EV+ L + + L F+E+ L LAYN G G +
Sbjct: 861 YQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPES 920
Query: 611 DDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE 670
+ T VP P + + V+ + +SW P NG +TGY ++++ E
Sbjct: 921 EPYIFQTPEGVPE-QPTFLKVIKVDKDTATLSWGLPKK--LNGNLTGYLLQYQIINDTYE 977
Query: 671 METLEPNNL-------WYLFTGLEKGSQYSFQVSAMTVNGTGPP 707
+ L N+ W+L + L ++Y F + A T G G P
Sbjct: 978 IGELNDINITTPSKPSWHL-SNLNATTKYKFYLRACTSQGCGKP 1020
Score = 109 bits (273), Expect = 2e-23
Identities = 227/1045 (21%), Positives = 402/1045 (38%), Gaps = 153/1045 (14%)
Query: 59 LDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCE 118
++C A+ + P W KDG ++G+ I N H H +G Y+C
Sbjct: 55 IECEAKGNPE-PTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHF---QGKYRCF 110
Query: 119 ASLGDSGSIISRTAKVAVAGPLRFLSQT-ESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQ 177
AS G +S + V +F + + + GD ++L C + +P +H
Sbjct: 111 AS-NKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNP-PKGLPPLHIYWMN 168
Query: 178 QDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSARNPA------------------ 218
+L I D RV + G L + ++ D Y C A P
Sbjct: 169 IELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLK 228
Query: 219 -SSRTGNEAEVRILSDPGLHRQLYFLQRP------SNVVAIEGKDAVLECCVSGYPPPSF 271
++ + + E+ ++ R+ L P S++ ++G+ +LEC G P P
Sbjct: 229 HANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQV 288
Query: 272 TWLR-GEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV- 329
W + G ++ + R K + G L I NV+ D G Y C T N +A+ + V+V
Sbjct: 289 DWNKIGGDLPKGRETKENY--GKTLKIENVSYQDKGNYRC--TASNFLGTATHDFHVIVE 344
Query: 330 --PPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYF-QIVGGSNLR 386
P W S +Y+ S I C G+P PT+ W NG V + +V +
Sbjct: 345 EPPRWTKKPQSAVYSTGSNGILL-CEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREIS 403
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVP--KPAIPSSSVLPSAPRDVVPVLVSSRF 444
+ + YQC A N G +A + V +P I + + V+ S F
Sbjct: 404 FTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKD-----GENYATVVGYSAF 458
Query: 445 VRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
+ + EA + Q EG R + + G+LQ+ + Y+ V
Sbjct: 459 LHCEFFASPEAVVSWQKVEEVKPLEG----RRYHIYENGTLQINRTTEEDAGSYSCWVEN 514
Query: 505 YNEWGPGESSQPIKVATQPELQVPGP-VENLQAV---------STSPTSILITWEPPAYA 554
++ I+ AT+ + P + L + S S+ ++W A
Sbjct: 515 AIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEA 574
Query: 555 NGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDIT 614
E++ ++ I +DG + + + + A+ S DIT
Sbjct: 575 -----------FEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALD---SAADIT 620
Query: 615 VVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR---HRKTTRRGEM 671
VT+ DVP PP+N+ L +RS++++W N I+ Y + +++ R E
Sbjct: 621 QVTVLDVPD-PPENLHLSERQNRSVRLTW--EAGADHNSNISEYIVEFEGNKEEPGRWEE 677
Query: 672 ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQ-PS 730
T + L +Y F+V A+ G PS + ++ PD+ P
Sbjct: 678 LTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS-----QPSDHHETPPAAPDRNPQ 732
Query: 731 SLHVRP-QTNCIIMSWTPPLN-----PNIVVRGYIIGYGVGSPYAE------TVRVDSKQ 778
++ V+ Q +I+ W P + P + R G + E T+RV +
Sbjct: 733 NIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPA 792
Query: 779 RYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838
Y + Y + ++A N G G DP Y +D+P + P
Sbjct: 793 VY---------APYDVKVQAINQLGSG------------PDPQSVTLYSG--EDYPDTAP 829
Query: 839 DLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRW-RTSFSASAKYKS 897
+ GV + T V+V+W+ +VPK++ ++ Y + W +T +
Sbjct: 830 VIH-------GVDVINST--LVKVTWS--TVPKDRVHGRLKGYQINWWKTKSLLDGRTHP 878
Query: 898 EDTTSLSYTA---TGLKPN----TMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKD 950
++ L ++ +G+ P+ + + +V+ ++ + S T E P P
Sbjct: 879 KEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQ-PTF 937
Query: 951 LTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNI----PIDDWIMETISGDRLT 1006
L VI + K A + SW P + NG +T Y+L Y + + ++D + T S + +
Sbjct: 938 LKVI-KVDKDTATL-SWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPS--KPS 993
Query: 1007 HQIMDLNLDTMYYFRIQARNSKGVG 1031
+ +LN T Y F ++A S+G G
Sbjct: 994 WHLSNLNATTKYKFYLRACTSQGCG 1018
Score = 80.5 bits (197), Expect = 1e-14
Identities = 213/994 (21%), Positives = 350/994 (35%), Gaps = 199/994 (20%)
Query: 143 LSQTESVTAFMGDTVL-LKCEVIGEPMPTIHWQKNQQ-----DLTPIPGDSRVVVLPSGA 196
+ Q++ AF D ++CE G P PT W K+ D IP ++
Sbjct: 38 IKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNE 97
Query: 197 LQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKD 256
IS Q G YRC A N E E + S P ++ + + EG
Sbjct: 98 GHISHFQ----GKYRCFASNKLGIAMSEEIEFIVPSVPKFPKE-----KIDPLEVEEGDP 148
Query: 257 AVLECCV-SGYPPPSFTWLRGE-EVIQLRSKKYSLLGGSNLLISNVTDDDS-GMYTCVVT 313
VL C G PP W+ E E I+ + Y G +L +NV + DS Y C
Sbjct: 149 IVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKG-DLYFANVEEKDSRNDYCCFAA 207
Query: 314 Y-------------------KNENISASA-------------ELTVLVPPWFLNHPSNLY 341
+ K+ N S+S+ + +L+PP S++
Sbjct: 208 FPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSIT 267
Query: 342 AYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCV 401
+ + EC G P P V+W K G + + G L+I V D+G Y+C
Sbjct: 268 ILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCT 327
Query: 402 AENEAGNAQTSAQLIVPKP----AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKG 457
A N G A +IV +P P S+V + ++ EA+G
Sbjct: 328 ASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGIL---------------LCEAEG 372
Query: 458 NIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESS 514
Q T+ + G DN A + P + T NL+P ++ A N G ++
Sbjct: 373 EPQP-TIKWRVNGSPVDNHPFAGDVVFPREISFT--NLQPNHTAVYQCEASNVHGTILAN 429
Query: 515 QPIKVATQPELQVPGPVENLQAV-----------STSPTSILITWEPPAYANGPVQGYRL 563
I V L EN V SP ++ ++W+ P++G R
Sbjct: 430 ANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAV-VSWQKVEEVK-PLEGRRY 487
Query: 564 FCTEVSTGK-EQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVP 622
E T + + E D SY N G T ++ + + +
Sbjct: 488 HIYENGTLQINRTTEEDAGSYSC-------------WVENAIGKTAVTANLDIRNATKLR 534
Query: 623 SAP--PQNVSLEVVN-----------SRSIKVSWLPPP-----SGTQNG--FITGYKIRH 662
+P P+ L ++ S+K+SW +GT++G I G +
Sbjct: 535 VSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTI 594
Query: 663 RKTTRRGEMETLEPNNLW--YLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
TLE ++ T L+ + + QV+ + V PP N + +E
Sbjct: 595 SNV-------TLEDQGIYCCSAHTALDSAADIT-QVTVLDV--PDPPENLHLSER----- 639
Query: 721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSP----YAETVRVDS 776
Q + ++W + N + YI+ + + E RV
Sbjct: 640 ----------------QNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQG 683
Query: 777 KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTS 836
K+ I L Y + A N G + P+ P D++ + P +
Sbjct: 684 KKTTV-ILPLAPFVRYQFRVIAVNEVGR-------------SQPSQPSDHH----ETPPA 725
Query: 837 VPDLSTPMLPPVGVQAVALTHDAVRVSWAD-NSVPKNQKTSEVRLYTVRWRTSFSASAKY 895
PD + P ++ A + + W S+ +N E Y V W+ A
Sbjct: 726 APDRN-----PQNIRVQASQPKEMIIKWEPLKSMEQNGPGLE---YRVTWKPQ---GAPV 774
Query: 896 KSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTY--EAAPTSAPKDLTV 953
+ E+ T ++T + P + V V + + T Y E P +AP V
Sbjct: 775 EWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGV 834
Query: 954 ITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNI------PIDDWIMETISGDRLTH 1007
V S P +G++ Y + + K++ P + I+ SG R +
Sbjct: 835 DVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILR-FSGQRNSG 893
Query: 1008 QIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
+ L+ + ++ + A NSKG GP S+P +F+T
Sbjct: 894 MVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQT 927
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 218 bits (555), Expect = 3e-56
Identities = 212/799 (26%), Positives = 331/799 (41%), Gaps = 61/799 (7%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
S+ +RG + L+C AE P+I W K+ GM + + + I+H
Sbjct: 278 SNKEELRGNVLSLECIAEG-LPTPIIYWAKED-----GMLPKNRTVYKNFEKTLQIIHVS 331
Query: 107 HHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGE 166
+ D G YQC A ++ I T V V +++ +++ G+ L C G
Sbjct: 332 --EADSGNYQCIAK--NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGN 387
Query: 167 PMPTIHWQKNQQDLTPIPGD-SRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNE 225
P P I W N + P D SR + + S +Q +Y+C+A N N
Sbjct: 388 PKPRISWLTNGVPIEIAPDDPSRKI--DGDTIIFSNVQERSSAVYQCNASNEYGYLLAN- 444
Query: 226 AEVRILSDPGLHRQLYFLQRPSNVV--AIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR 283
A V +L++P + P+N + I + A+L+C G P P+ W +G + L
Sbjct: 445 AFVNVLAEPPR------ILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALH 498
Query: 284 SKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAY 343
Y L L I D +G YTCV K L + P W + P
Sbjct: 499 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQ 558
Query: 344 ESMDIEFECTVSGKPV--PTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCV 401
+ FEC V TV W+K+ + +PSD V +L + V D G Y CV
Sbjct: 559 RGSMVSFECKVKHDHTLSLTVLWLKD-NRELPSDERFTVDKDHLVVADVSDDDSGTYTCV 617
Query: 402 AENEAGNAQTSAQLIVPKPAIPSSSV--LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNI 459
A + SA L V P + V +P+ P D+ + V+LSW P + I
Sbjct: 618 ANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPI 677
Query: 460 QTFTVFFSREGDNRERALNTTQPGSLQLTVG-NLKPEAMYTFRVVAYNEWG---PGESS- 514
F + + + T+ Q T L P Y+FRV+A N G P E+S
Sbjct: 678 TKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASE 737
Query: 515 QPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCTEVSTGK 572
Q + A++P+ + P VE L + P +++ITW+P +NGP Y++ +
Sbjct: 738 QYLTKASEPD-KNPTAVEGL---GSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD 793
Query: 573 E-QNIEVDGLS-YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVS 630
E ++ V +S Y + G F Y ++ A N G + + D+P P NV
Sbjct: 794 EWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVR 853
Query: 631 LEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEME---------TLEPNNLWY 681
+ VVNS +V W P P + G + GY+I + KT + T + +
Sbjct: 854 VNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHG 913
Query: 682 LFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLH-VRPQTNC 740
+ GLE S Y+ V + G GP S TPE VP PSSL V P +
Sbjct: 914 MLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEG------VPSAPSSLKIVNPTLDS 967
Query: 741 IIMSWTPPLNPNIVVRGYIIGYGVGSPYAE-----TVRVDSKQRYYSIERLESSSHYVIS 795
+ + W PP +PN ++ Y + Y + E +++ + + ++++ L S+ Y
Sbjct: 968 LTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFY 1027
Query: 796 LKAFNNAGEGVPLYESATT 814
A +AG G + E A T
Sbjct: 1028 FYAQTSAGSGSQITEEAVT 1046
Score = 147 bits (371), Expect = 7e-35
Identities = 238/1066 (22%), Positives = 395/1066 (37%), Gaps = 161/1066 (15%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHS 105
P D + N+++ C A+ + P W ++G H + D LI NI+
Sbjct: 53 PKDYIIDPRENIVIQCEAKG-KPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSE 111
Query: 106 RHHKPDEGLYQCEASLGDSGSIISRTAKVAVA-GPLRFLSQTESVTAFMGDTVLLKCE-V 163
+ EG+YQC A + G+ +S V + PL + E +T G +++L C
Sbjct: 112 GKAETYEGVYQCTAR-NERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPP 170
Query: 164 IGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSAR------- 215
IG P P I W N +P RV +G L S + P D Y C AR
Sbjct: 171 IGLPPPIIFWMDN--SFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTI 228
Query: 216 ---NPASSRT-----GNEAEVRILSDPGLHRQLYFLQRP----------SNVVAIEGKDA 257
P S + N+ LSD + +RP SN + G
Sbjct: 229 QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVL 288
Query: 258 VLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNE 317
LEC G P P W + + ++ Y L I +V++ DSG Y C+
Sbjct: 289 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNF-EKTLQIIHVSEADSGNYQCIAKNALG 347
Query: 318 NISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNG--DVVIPSD 375
I + + V P+++ P NL D C +G P P ++W+ NG + P D
Sbjct: 348 AIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD 407
Query: 376 YFQIVGGSNLRILGVVKSDEGFYQCVAENEAG----NAQTSAQLIVPKPAIPSSS---VL 428
+ + G + V + YQC A NE G NA + P+ P+++ V+
Sbjct: 408 PSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVI 467
Query: 429 PSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLT 488
+ P + S + W AKG+ ++ E G+L++
Sbjct: 468 ANRPALLDCAFFGSPLPTIEWF--KGAKGSALHEDIYVLHEN------------GTLEIP 513
Query: 489 VGNLKPEAMYTFRVVAYNEWGPG------ESSQPIKVATQPELQVPGPVENLQAVS---- 538
V + ++ T+ VA N+ G E P + QPE V V+ VS
Sbjct: 514 VA--QKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAV---VQRGSMVSFECK 568
Query: 539 ---TSPTSILITW-----EPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKK 590
S+ + W E P+ V L +VS + D +Y
Sbjct: 569 VKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVS-------DDDSGTYTCVANTT 621
Query: 591 FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
S + V T + DVP+ PP ++ L +S+++SW P
Sbjct: 622 LDSVSASAVL------SVVAPTPTPAPVYDVPN-PPFDLELTDQLDKSVQLSW--TPGDD 672
Query: 651 QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFT---GLEKGSQ--------YSFQVSAM 699
N IT + I + + + LW+ T G + +Q YSF+V A+
Sbjct: 673 NNSPITKFIIEYE--------DAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAV 724
Query: 700 TVNGTGPPSNWYTAETPENDLDESQVPDQ-PSSLH-VRPQTNCIIMSWTPPLNPNIVVRG 757
G PS E E L ++ PD+ P+++ + + + ++++W P + G
Sbjct: 725 NSIGKSLPS-----EASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP-------LNG 772
Query: 758 YIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSI 817
+ G G Y + R ++ + + S Y++S G P + +
Sbjct: 773 F-ESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVS---------GTPTFVPYLIK-- 820
Query: 818 TDPTDPVDYYPLLDDFPTSVPDLS---TPMLPPVGVQAVALTHDAVRVSWADNSVPKNQK 874
+ + + P P V S PM+ P V+ + V W + VP
Sbjct: 821 VQALNDMGFAP----EPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHW--DPVPLKSI 874
Query: 875 TSEVRLYTV-RWRTSFSASAKYKSEDTTSLSYTAT-------GLKPNTMYEFSVMVTKNR 926
++ Y + W+T S+ + + L++ + GL+P + Y +V V +
Sbjct: 875 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 934
Query: 927 RSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFY-T 985
S T E P SAP L ++ ++ + W PP NG +T Y L Y
Sbjct: 935 GEGPASPDRVFNTPEGVP-SAPSSLKIV--NPTLDSLTLEWDPPSHPNGILTEYTLKYQP 991
Query: 986 LDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVG 1031
++ + + I ++ + +LN T Y F A+ S G G
Sbjct: 992 INSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1037
Score = 140 bits (354), Expect = 7e-33
Identities = 228/1060 (21%), Positives = 383/1060 (36%), Gaps = 141/1060 (13%)
Query: 45 EPSDAVTMRGG-NVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNIL 103
E + +T++ G +++L C P+I W D L ER Q NG L N+L
Sbjct: 150 EKLEPITLQSGQSLVLPCRPPIGLPPPIIFWM-DNSFQRLPQSERVSQGLNGDLYFSNVL 208
Query: 104 ---------------HSRHHKPDEGLYQCEASLGDSGSIISRT--------AKVAVAGPL 140
H++ + + + S+ + I+ AK + P
Sbjct: 209 PEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPP 268
Query: 141 RFLSQTESVT---AFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGAL 197
FL+ + + G+ + L+C G P P I+W K L P + V L
Sbjct: 269 TFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGML---PKNRTVYKNFEKTL 325
Query: 198 QISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDA 257
QI + D G Y+C A+N A + VR+ + P Y++ P N+V G+D
Sbjct: 326 QIIHVSEADSGNYQCIAKN-ALGAIHHTISVRVKAAP------YWITAPQNLVLSPGEDG 378
Query: 258 VLECCVSGYPPPSFTWLRGEEVIQLRSKKYSL-LGGSNLLISNVTDDDSGMYTCVVTYKN 316
L C +G P P +WL I++ S + G ++ SNV + S +Y C + +
Sbjct: 379 TLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEY 438
Query: 317 ENISASAELTVLV-PPWFLNHPSNLY-AYESMDIEFECTVSGKPVPTVNWMKNGD-VVIP 373
+ A+A + VL PP L + LY + +C G P+PT+ W K +
Sbjct: 439 GYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALH 498
Query: 374 SDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPR 433
D + + L I K G Y CVA N+ G A+ L + P + + P
Sbjct: 499 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDP-----TWIVKQPE 553
Query: 434 DVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT-QPGSLQLTVGNL 492
V R +S+ + + + TV + + DNRE + L V ++
Sbjct: 554 ----YAVVQRGSMVSFECKVKHDHTL-SLTVLWLK--DNRELPSDERFTVDKDHLVVADV 606
Query: 493 KPEAMYTFRVVAYNEWGPGESSQPIKVATQ-----PELQVPGPVENLQAVSTSPTSILIT 547
+ T+ VA +S + V P VP P +L+ S+ ++
Sbjct: 607 SDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLS 666
Query: 548 WEPPAYANGPVQGYRLFCTEVSTGK---EQNIEVDGLSYKLE-GLKKFTEYSLRFLAYNR 603
W P N P+ + + + EV G + L + YS R +A N
Sbjct: 667 WTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNS 726
Query: 604 YGPGVSTD-DITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRH 662
G + ++ +T + P P V ++ ++W P NG YK+
Sbjct: 727 IGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSW 786
Query: 663 RKTTRRGEMETLEPNNLW-YLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLD 721
R+ E ++ N+ Y+ +G Y +V A+ G P + E D
Sbjct: 787 RQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGE---D 843
Query: 722 ESQVPDQPSSLHVRPQTNCII-MSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
V P ++ V + + + W P P +RG++ GY + Y + SK+
Sbjct: 844 LPMVA--PGNVRVNVVNSTLAEVHWDPV--PLKSIRGHLQGYRI---YYWKTQSSSKRNR 896
Query: 781 YSIER----------------LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPV 824
IE+ LE SHY ++++ N GEG P P
Sbjct: 897 RHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEG--------------PASPD 942
Query: 825 DYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
+ + P VP P ++ V T D++ + W S P T YT++
Sbjct: 943 RVF----NTPEGVPSA------PSSLKIVNPTLDSLTLEWDPPSHPNGILTE----YTLK 988
Query: 885 WRTSFSASAKYKSED----TTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTY 940
++ S D +T L +T Y+F + S + TT
Sbjct: 989 YQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTV 1048
Query: 941 EAAPTSAPK-----------DLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKN 989
+ A P ++ +T +SW+ E + Y+ +
Sbjct: 1049 DEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWE--YEGPEHVNFYVEYGVAGSK 1106
Query: 990 IPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKG 1029
++W E ++G R + L T Y R+ A G
Sbjct: 1107 ---EEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSG 1143
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQL-RSKKYSLLGGSNLLISNVTD 302
Q P + + ++ V++C G PPPSF+W R + + ++ G+ LI N+
Sbjct: 51 QSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMS 110
Query: 303 DD-----SGMYTCVVTYKNENISASAELTVLVPP----WFLN--HPSNLYAYESMDIEFE 351
+ G+Y C T +NE +A + V+ P W P L + +S+ +
Sbjct: 111 EGKAETYEGVYQC--TARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCR 168
Query: 352 CTVSGKPVPTVNWMKNGDVVIP 373
+ G P P + WM N +P
Sbjct: 169 PPI-GLPPPIIFWMDNSFQRLP 189
Score = 35.4 bits (80), Expect = 0.40
Identities = 71/332 (21%), Positives = 124/332 (37%), Gaps = 45/332 (13%)
Query: 725 VPDQPSSLHVRPQTN-CIIMSWTPPLNPNIVVRGYIIGY--GVGSP--YAETVRVDSKQR 779
VP+ P L + Q + + +SWTP + N + +II Y + P + V Q
Sbjct: 646 VPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 705
Query: 780 YYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPD 839
+ +L +Y + A N+ G+ +P A+ + +T ++P D PT+V
Sbjct: 706 TAQL-KLSPYVNYSFRVMAVNSIGKSLP--SEASEQYLTKASEP-------DKNPTAVEG 755
Query: 840 LSTPMLPPVGVQAVALTHDAVRVSWAD-NSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE 898
L + D + ++W N N + Y V WR ++ S
Sbjct: 756 LGSEP-------------DNLVITWKPLNGFESNGPGLQ---YKVSWRQK-DGDDEWTSV 798
Query: 899 DTTSLS-YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITRE 957
++S Y +G Y V + + + E P AP ++ V
Sbjct: 799 VVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVN 858
Query: 958 GKPRAVIVSWQP-PLEA-NGKITAYILFYTLDKNIP------IDDWIMETISGDRLTHQI 1009
V W P PL++ G + Y ++Y ++ I+ I+ T G + +
Sbjct: 859 ST--LAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKIL-TFQGSKTHGML 915
Query: 1010 MDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
L + Y ++ N KG GP S +F T
Sbjct: 916 PGLEPFSHYTLNVRVVNGKGEGPASPDRVFNT 947
Score = 34.7 bits (78), Expect = 0.68
Identities = 36/127 (28%), Positives = 55/127 (43%), Gaps = 11/127 (8%)
Query: 932 SMTAHATTYEAAPTSAPKDLTVITR--------EGKPRAVIVSWQPPLEANGKITAYILF 983
S++A A APT P + + + ++V +SW P + N IT +I+
Sbjct: 624 SVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIE 683
Query: 984 YTLDKNIPIDDWIMET-ISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTL 1042
Y + P W +T +SG + T Q+ L+ Y FR+ A NS G S+
Sbjct: 684 YEDAMHKP-GLWHHQTEVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLT 741
Query: 1043 KVEHPDK 1049
K PDK
Sbjct: 742 KASEPDK 748
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 213 bits (543), Expect = 8e-55
Identities = 210/797 (26%), Positives = 328/797 (41%), Gaps = 67/797 (8%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSR 106
S+ +RG + L+C AE P+I W K+ GM + + + I+H
Sbjct: 272 SNKEELRGNVLSLECIAEG-LPTPIIYWAKED-----GMLPKNRTVYKNFEKTLQIIHVS 325
Query: 107 HHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGE 166
+ D G YQC A ++ I T V V +++ +++ G+ L C G
Sbjct: 326 --EADSGNYQCIAK--NALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGN 381
Query: 167 PMPTIHWQKNQQDLTPIPGD-SRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNE 225
P P I W N + P D SR + + S +Q +Y+C+A N N
Sbjct: 382 PKPRISWLTNGVPIEIAPDDPSRKI--DGDTIIFSNVQERSSAVYQCNASNEYGYLLAN- 438
Query: 226 AEVRILSDPGLHRQLYFLQRPSNVV--AIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR 283
A V +L++P + P+N + I + A+L+C G P P+ W +G + L
Sbjct: 439 AFVNVLAEPPR------ILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALH 492
Query: 284 SKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAY 343
Y L L I D +G YTCV K L + P W + P
Sbjct: 493 EDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQ 552
Query: 344 ESMDIEFECTVSGKPV--PTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCV 401
+ FEC V TV W+K+ + +PSD V +L + V D G Y CV
Sbjct: 553 RGSMVSFECKVKHDHTLSLTVLWLKD-NRELPSDERFTVDKDHLVVADVSDDDSGTYTCV 611
Query: 402 AENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQT 461
A + SA L V +P+ P D+ + V+LSW P + I
Sbjct: 612 ANTTLDSVSASAVLSVVD--------VPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITK 663
Query: 462 FTVFFSREGDNRERALNTTQPGSLQLTVG-NLKPEAMYTFRVVAYNEWG---PGESS-QP 516
F + + + T+ Q T L P Y+FRV+A N G P E+S Q
Sbjct: 664 FIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQY 723
Query: 517 IKVATQPELQVPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCTEVSTGKE- 573
+ A++P+ + P VE L + P +++ITW+P +NGP Y++ + E
Sbjct: 724 LTKASEPD-KNPTAVEGL---GSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEW 779
Query: 574 QNIEVDGLS-YKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLE 632
++ V +S Y + G F Y ++ A N G + + D+P P NV +
Sbjct: 780 TSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVN 839
Query: 633 VVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEME---------TLEPNNLWYLF 683
VVNS +V W P P + G + GY+I + KT + T + + +
Sbjct: 840 VVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGML 899
Query: 684 TGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLH-VRPQTNCII 742
GLE S Y+ V + G GP S TPE VP PSSL V P + +
Sbjct: 900 PGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEG------VPSAPSSLKIVNPTLDSLT 953
Query: 743 MSWTPPLNPNIVVRGYIIGYGVGSPYAE-----TVRVDSKQRYYSIERLESSSHYVISLK 797
+ W PP +PN ++ Y + Y + E +++ + + ++++ L S+ Y
Sbjct: 954 LEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFY 1013
Query: 798 AFNNAGEGVPLYESATT 814
A +AG G + E A T
Sbjct: 1014 AQTSAGSGSQITEEAVT 1030
Score = 147 bits (370), Expect = 9e-35
Identities = 237/1066 (22%), Positives = 395/1066 (37%), Gaps = 171/1066 (16%)
Query: 46 PSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHS 105
P D + N+++ C A+ + P W ++G H + D LI NI+
Sbjct: 47 PKDYIIDPRENIVIQCEAKG-KPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSE 105
Query: 106 RHHKPDEGLYQCEASLGDSGSIISRTAKVAVA-GPLRFLSQTESVTAFMGDTVLLKCE-V 163
+ EG+YQC A + G+ +S V + PL + E +T G +++L C
Sbjct: 106 GKAETYEGVYQCTAR-NERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPP 164
Query: 164 IGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI-GIYRCSAR------- 215
IG P P I W N +P RV +G L S + P D Y C AR
Sbjct: 165 IGLPPPIIFWMDN--SFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTI 222
Query: 216 ---NPASSRT-----GNEAEVRILSDPGLHRQLYFLQRP----------SNVVAIEGKDA 257
P S + N+ LSD + +RP SN + G
Sbjct: 223 QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVL 282
Query: 258 VLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNE 317
LEC G P P W + + ++ Y L I +V++ DSG Y C+
Sbjct: 283 SLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNF-EKTLQIIHVSEADSGNYQCIAKNALG 341
Query: 318 NISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNG--DVVIPSD 375
I + + V P+++ P NL D C +G P P ++W+ NG + P D
Sbjct: 342 AIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD 401
Query: 376 YFQIVGGSNLRILGVVKSDEGFYQCVAENEAG----NAQTSAQLIVPKPAIPSSS---VL 428
+ + G + V + YQC A NE G NA + P+ P+++ V+
Sbjct: 402 PSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVI 461
Query: 429 PSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLT 488
+ P + S + W AKG+ ++ E G+L++
Sbjct: 462 ANRPALLDCAFFGSPLPTIEWF--KGAKGSALHEDIYVLHEN------------GTLEIP 507
Query: 489 VGNLKPEAMYTFRVVAYNEWGPG------ESSQPIKVATQPELQVPGPVENLQAVS---- 538
V + ++ T+ VA N+ G E P + QPE V V+ VS
Sbjct: 508 VA--QKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAV---VQRGSMVSFECK 562
Query: 539 ---TSPTSILITW-----EPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKK 590
S+ + W E P+ V L +VS + D +Y
Sbjct: 563 VKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVS-------DDDSGTYTCVANTT 615
Query: 591 FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
S V+++ DVP+ PP ++ L +S+++SW P
Sbjct: 616 LDSVSAS----------------AVLSVVDVPN-PPFDLELTDQLDKSVQLSW--TPGDD 656
Query: 651 QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFT---GLEKGSQ--------YSFQVSAM 699
N IT + I + + + LW+ T G + +Q YSF+V A+
Sbjct: 657 NNSPITKFIIEYE--------DAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAV 708
Query: 700 TVNGTGPPSNWYTAETPENDLDESQVPDQ-PSSLH-VRPQTNCIIMSWTPPLNPNIVVRG 757
G PS E E L ++ PD+ P+++ + + + ++++W P + G
Sbjct: 709 NSIGKSLPS-----EASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKP-------LNG 756
Query: 758 YIIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSI 817
+ G G Y + R ++ + + S Y++S G P + +
Sbjct: 757 F-ESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVS---------GTPTFVPYLIK-- 804
Query: 818 TDPTDPVDYYPLLDDFPTSVPDLS---TPMLPPVGVQAVALTHDAVRVSWADNSVPKNQK 874
+ + + P P V S PM+ P V+ + V W + VP
Sbjct: 805 VQALNDMGFAP----EPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHW--DPVPLKSI 858
Query: 875 TSEVRLYTV-RWRTSFSASAKYKSEDTTSLSYTAT-------GLKPNTMYEFSVMVTKNR 926
++ Y + W+T S+ + + L++ + GL+P + Y +V V +
Sbjct: 859 RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGK 918
Query: 927 RSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFY-T 985
S T E P SAP L ++ ++ + W PP NG +T Y L Y
Sbjct: 919 GEGPASPDRVFNTPEGVP-SAPSSLKIV--NPTLDSLTLEWDPPSHPNGILTEYTLKYQP 975
Query: 986 LDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVG 1031
++ + + I ++ + +LN T Y F A+ S G G
Sbjct: 976 INSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1021
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQL-RSKKYSLLGGSNLLISNVTD 302
Q P + + ++ V++C G PPPSF+W R + + ++ G+ LI N+
Sbjct: 45 QSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMS 104
Query: 303 DD-----SGMYTCVVTYKNENISASAELTVLVPP----WFLN--HPSNLYAYESMDIEFE 351
+ G+Y C T +NE +A + V+ P W P L + +S+ +
Sbjct: 105 EGKAETYEGVYQC--TARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCR 162
Query: 352 CTVSGKPVPTVNWMKNGDVVIP 373
+ G P P + WM N +P
Sbjct: 163 PPI-GLPPPIIFWMDNSFQRLP 183
Score = 35.4 bits (80), Expect = 0.40
Identities = 71/332 (21%), Positives = 124/332 (37%), Gaps = 45/332 (13%)
Query: 725 VPDQPSSLHVRPQTN-CIIMSWTPPLNPNIVVRGYIIGY--GVGSP--YAETVRVDSKQR 779
VP+ P L + Q + + +SWTP + N + +II Y + P + V Q
Sbjct: 630 VPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 689
Query: 780 YYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPD 839
+ +L +Y + A N+ G+ +P A+ + +T ++P D PT+V
Sbjct: 690 TAQL-KLSPYVNYSFRVMAVNSIGKSLP--SEASEQYLTKASEP-------DKNPTAVEG 739
Query: 840 LSTPMLPPVGVQAVALTHDAVRVSWAD-NSVPKNQKTSEVRLYTVRWRTSFSASAKYKSE 898
L + D + ++W N N + Y V WR ++ S
Sbjct: 740 LGSEP-------------DNLVITWKPLNGFESNGPGLQ---YKVSWRQK-DGDDEWTSV 782
Query: 899 DTTSLS-YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITRE 957
++S Y +G Y V + + + E P AP ++ V
Sbjct: 783 VVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVN 842
Query: 958 GKPRAVIVSWQP-PLEA-NGKITAYILFYTLDKNIP------IDDWIMETISGDRLTHQI 1009
V W P PL++ G + Y ++Y ++ I+ I+ T G + +
Sbjct: 843 ST--LAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKIL-TFQGSKTHGML 899
Query: 1010 MDLNLDTMYYFRIQARNSKGVGPLSDPILFRT 1041
L + Y ++ N KG GP S +F T
Sbjct: 900 PGLEPFSHYTLNVRVVNGKGEGPASPDRVFNT 931
Score = 33.9 bits (76), Expect = 1.2
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 5/119 (4%)
Query: 932 SMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIP 991
S++A A + P DL + + K +V +SW P + N IT +I+ Y + P
Sbjct: 618 SVSASAVLSVVDVPNPPFDLELTDQLDK--SVQLSWTPGDDNNSPITKFIIEYEDAMHKP 675
Query: 992 IDDWIMET-ISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDK 1049
W +T +SG + T Q+ L+ Y FR+ A NS G S+ K PDK
Sbjct: 676 -GLWHHQTEVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDK 732
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 209 bits (531), Expect = 2e-53
Identities = 203/725 (28%), Positives = 302/725 (41%), Gaps = 91/725 (12%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
F P+D V G +L+C P I WKKD + + D++++++S G L+I
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI----DDKEERISIRGGKLMI 206
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
N K D G+Y C + G S A++ V FL + + + V
Sbjct: 207 SNT-----RKSDAGMYTCVGT-NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF 260
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
+C+V G+P PT+ W+K+ DL R + L+I + D G Y C A N
Sbjct: 261 RCQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 316
Query: 220 SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEE 278
+ A + + + P F+ RP + + +G+ C G P P+ W + G +
Sbjct: 317 KMEAS-ATLTVRAPP------QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ 369
Query: 279 VI------QLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---- 328
+ Q + + S+ +L I+N+ D+G Y C +I A A+L V
Sbjct: 370 NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 429
Query: 329 --VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSNL 385
PP L P+N +C +G P+P ++W+K G D I L
Sbjct: 430 DRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTL 489
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSS-----SVLPSAPRDVVPVLV 440
+I + SD G Y CVA + +G SA L V + S S LP P V
Sbjct: 490 QIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV 549
Query: 441 SSRFVRLSWRP------PAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKP 494
+ V LSW+P PA A I+ F+ S + TT TV L+P
Sbjct: 550 TKNSVTLSWQPGTPGTLPASAY-IIEAFSQSVSNSWQTVANHVKTTL-----YTVRGLRP 603
Query: 495 EAMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQA--------------V 537
+Y F V A N G P S P++ TQ V++ Q V
Sbjct: 604 NTIYLFMVRAINPQGLSDPSPMSDPVR--TQDISPPAQGVDHRQVQKELGDVLVRLHNPV 661
Query: 538 STSPTSILITW---EPPAYANGPVQGYRLFCTEVS----TGKEQNIEVD---GLSYKLEG 587
+PT++ +TW P + +QGYR+ + S T QN++ S L
Sbjct: 662 VLTPTTVQVTWTVDRQPQF----IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVN 717
Query: 588 LKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV---NSRSIKVSWL 644
LKK Y ++ Y G+ ++ TV T + PSAPPQ+V++ V NS SI VSW
Sbjct: 718 LKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWD 777
Query: 645 PPPSGTQNGFITGYKIRHRKTTRRGEM-ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNG 703
PPP QNG I YKI R + +T++ + GL G QY +V+A T G
Sbjct: 778 PPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAG 837
Query: 704 TGPPS 708
G S
Sbjct: 838 VGVKS 842
Score = 208 bits (529), Expect = 3e-53
Identities = 213/822 (25%), Positives = 319/822 (38%), Gaps = 85/822 (10%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + PSD + +G L+C AE R P I+W KDG + D+ + L +GSL
Sbjct: 48 RIVEHPSDVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R KPDEG Y C A G +SR A + VA LR F V G+
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVAR-NYLGEAVSRNASLEVA-LLRDDFRQNPTDVVVAAGE 164
Query: 156 TVLLKCEVI-GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+L+C+ G P PTI+W+K D I + + G L IS + D G+Y C
Sbjct: 165 PAILECQPPRGHPEPTIYWKK---DKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG 221
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N R + AE+ + P FL+RP N V +E + C V G P P+ W
Sbjct: 222 TNMVGERDSDPAELTVFERPT------FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
+ + L +Y + L I D G Y C+ + + ASA LTV PP F+
Sbjct: 276 KDDA--DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFV 333
Query: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI--------PSDYFQIVGGSNLR 386
P + + + F C G P P V W K G + P+ + +L
Sbjct: 334 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 393
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446
I + +SD G+Y C A AG+ AQL V + VL P ++ +++ +
Sbjct: 394 ITNIQRSDAGYYICQALTVAGSILAKAQLEV-------TDVLTDRPPPIILQGPANQTLA 446
Query: 447 LSWRPPAEAKGNIQTFTVF-FSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
+ + K V + +EG R+ + G+LQ + NL+ T+
Sbjct: 447 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQ--IKNLRISDTGTYTC 504
Query: 503 VAYNEWGPGESSQPIKVATQPEL--------QVPGPVENLQAVSTSPTSILITWEPPAYA 554
VA + G S + V +PGP Q + S+ ++W+P
Sbjct: 505 VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPG 564
Query: 555 NGPVQGY--RLFCTEVSTGKEQNI-EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTD 611
P Y F VS + V Y + GL+ T Y A N G +
Sbjct: 565 TLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSP 624
Query: 612 DITVVTLSDVPSAPPQNVSLE-----------------VVNSRSIKVSWLPPPSGTQNGF 654
V D+ S P Q V V+ +++V+W Q F
Sbjct: 625 MSDPVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTW---TVDRQPQF 680
Query: 655 ITGYKIRHRK------TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708
I GY++ +R+ T+ ++ P + L+KG Y +V G S
Sbjct: 681 IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDS 740
Query: 709 NWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPL--NPNIVVRGYIIG-YGV 764
T T E S P + L V + I +SW PP + N +++ Y I G
Sbjct: 741 ESKTVRTTEE--APSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGN 798
Query: 765 GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
+ + VD+ R I L Y + + A +AG GV
Sbjct: 799 ETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 840
Score = 191 bits (484), Expect = 6e-48
Identities = 229/842 (27%), Positives = 332/842 (39%), Gaps = 117/842 (13%)
Query: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
P R + V G+ L C+ G P PTI W K+ + + D R ++LPSG+
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
L R+ G D G Y C ARN A EV +L D F Q P++V
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------FRQNPTDV 158
Query: 250 VAIEGKDAVLEC-CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
V G+ A+LEC G+P P+ W + + I + ++ S+ GG L+ISN D+GMY
Sbjct: 159 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG-KLMISNTRKSDAGMY 217
Query: 309 TCVVT-YKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
TCV T E S AELTV P FL P N E +EF C V G P PTV W K+
Sbjct: 218 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 277
Query: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
D +P + I LRI + +DEG Y C+AEN G + SA L V P P V
Sbjct: 278 -DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP--PQFVV 334
Query: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN-TTQPGSL- 485
PRD ++ R V P E KGN Q VF+ +EG N QP S
Sbjct: 335 ---RPRD--QIVAQGRTVTF----PCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRC 384
Query: 486 ------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA-----TQPELQVPGPVENL 534
LT+ N++ + A G + ++V P + + GP
Sbjct: 385 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 444
Query: 535 QAV---------STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV-DGLSYK 584
AV +T +I+W + P + R E T + +N+ + D +Y
Sbjct: 445 LAVDGTALLKCKATGDPLPVISWLKEGF-TFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503
Query: 585 LEGLKKFTEYS-LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSW 643
E S L G +S + LSD+P PP + V S+ +SW
Sbjct: 504 CVATSSSGETSWSAVLDVTESGATISKN----YDLSDLP-GPPSKPQVTDVTKNSVTLSW 558
Query: 644 LPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFT--GLEKGSQYSFQVSAMTV 701
P GT + Y I + +T+ + L+T GL + Y F V A+
Sbjct: 559 QPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINP 616
Query: 702 NGTGPPS------NWYTAETPENDLDESQVPDQPSSLHVRPQTNCII------MSWTPPL 749
G PS P +D QV + + VR ++ ++WT
Sbjct: 617 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 676
Query: 750 NPNIVVRGYIIGYGVGSPYAET---VRVDSK---QRYYSIERLESSSHYVISLKAFNNAG 803
P ++GY + Y S T +D+K +R + L+ Y I ++ + N
Sbjct: 677 QPQF-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEF 735
Query: 804 EGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL---THDAV 860
+G+ ES T R+ + P PP V + + ++
Sbjct: 736 QGMD-SESKTVRTTEE----------------------APSAPPQSVTVLTVGSYNSTSI 772
Query: 861 RVSWADNSVPKNQK--TSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEF 918
VSW D P +Q E +++ + T F + K+ D S GL P Y
Sbjct: 773 SVSW-DPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIGGLFPGIQYRV 828
Query: 919 SV 920
V
Sbjct: 829 EV 830
Score = 71.6 bits (174), Expect = 5e-12
Identities = 85/341 (24%), Positives = 137/341 (40%), Gaps = 42/341 (12%)
Query: 715 TPENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAE 770
T + D S +P PS V T N + +SW P + YII V + + +
Sbjct: 527 TISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSW-Q 585
Query: 771 TVRVDSKQRYYSIERLESSSHYVISLKAFNNAG--EGVPLYESATTRSITDPTDPVDYYP 828
TV K Y++ L ++ Y+ ++A N G + P+ + T+ I+ P VD+
Sbjct: 586 TVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQ 645
Query: 829 LLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWR-- 886
+ + + L P V LT V+V+W + P+ ++ Y V +R
Sbjct: 646 VQKELGDVLVRLHNP---------VVLTPTTVQVTWTVDRQPQF-----IQGYRVMYRQT 691
Query: 887 TSFSASAKYKSEDT---TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAA 943
+ A++ +++ D T S LK YE V N S + T E A
Sbjct: 692 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 751
Query: 944 PTSAPKDLTVIT-REGKPRAVIVSWQPPL--EANGKITAYILFYTLDK-----NIPIDDW 995
P++ P+ +TV+T ++ VSW PP NG I Y ++ ++ N +D
Sbjct: 752 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 811
Query: 996 IMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
I I G L Y + A S GVG S+P
Sbjct: 812 IRSVIIG--------GLFPGIQYRVEVAASTSAGVGVKSEP 844
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 209 bits (531), Expect = 2e-53
Identities = 203/725 (28%), Positives = 302/725 (41%), Gaps = 91/725 (12%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
F P+D V G +L+C P I WKKD + + D++++++S G L+I
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI----DDKEERISIRGGKLMI 190
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
N K D G+Y C + G S A++ V FL + + + V
Sbjct: 191 SNT-----RKSDAGMYTCVGT-NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF 244
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
+C+V G+P PT+ W+K+ DL R + L+I + D G Y C A N
Sbjct: 245 RCQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
Query: 220 SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEE 278
+ A + + + P F+ RP + + +G+ C G P P+ W + G +
Sbjct: 301 KMEAS-ATLTVRAPP------QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ 353
Query: 279 VI------QLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---- 328
+ Q + + S+ +L I+N+ D+G Y C +I A A+L V
Sbjct: 354 NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
Query: 329 --VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSNL 385
PP L P+N +C +G P+P ++W+K G D I L
Sbjct: 414 DRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTL 473
Query: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSS-----SVLPSAPRDVVPVLV 440
+I + SD G Y CVA + +G SA L V + S S LP P V
Sbjct: 474 QIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV 533
Query: 441 SSRFVRLSWRP------PAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKP 494
+ V LSW+P PA A I+ F+ S + TT TV L+P
Sbjct: 534 TKNSVTLSWQPGTPGTLPASAY-IIEAFSQSVSNSWQTVANHVKTTL-----YTVRGLRP 587
Query: 495 EAMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQA--------------V 537
+Y F V A N G P S P++ TQ V++ Q V
Sbjct: 588 NTIYLFMVRAINPQGLSDPSPMSDPVR--TQDISPPAQGVDHRQVQKELGDVLVRLHNPV 645
Query: 538 STSPTSILITW---EPPAYANGPVQGYRLFCTEVS----TGKEQNIEVD---GLSYKLEG 587
+PT++ +TW P + +QGYR+ + S T QN++ S L
Sbjct: 646 VLTPTTVQVTWTVDRQPQF----IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVN 701
Query: 588 LKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV---NSRSIKVSWL 644
LKK Y ++ Y G+ ++ TV T + PSAPPQ+V++ V NS SI VSW
Sbjct: 702 LKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWD 761
Query: 645 PPPSGTQNGFITGYKIRHRKTTRRGEM-ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNG 703
PPP QNG I YKI R + +T++ + GL G QY +V+A T G
Sbjct: 762 PPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAG 821
Query: 704 TGPPS 708
G S
Sbjct: 822 VGVKS 826
Score = 208 bits (529), Expect = 3e-53
Identities = 213/822 (25%), Positives = 319/822 (38%), Gaps = 85/822 (10%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + PSD + +G L+C AE R P I+W KDG + D+ + L +GSL
Sbjct: 32 RIVEHPSDVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R KPDEG Y C A G +SR A + VA LR F V G+
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVAR-NYLGEAVSRNASLEVA-LLRDDFRQNPTDVVVAAGE 148
Query: 156 TVLLKCEVI-GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+L+C+ G P PTI+W+K D I + + G L IS + D G+Y C
Sbjct: 149 PAILECQPPRGHPEPTIYWKK---DKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N R + AE+ + P FL+RP N V +E + C V G P P+ W
Sbjct: 206 TNMVGERDSDPAELTVFERPT------FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
+ + L +Y + L I D G Y C+ + + ASA LTV PP F+
Sbjct: 260 KDDA--DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFV 317
Query: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI--------PSDYFQIVGGSNLR 386
P + + + F C G P P V W K G + P+ + +L
Sbjct: 318 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446
I + +SD G+Y C A AG+ AQL V + VL P ++ +++ +
Sbjct: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEV-------TDVLTDRPPPIILQGPANQTLA 430
Query: 447 LSWRPPAEAKGNIQTFTVF-FSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
+ + K V + +EG R+ + G+LQ + NL+ T+
Sbjct: 431 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQ--IKNLRISDTGTYTC 488
Query: 503 VAYNEWGPGESSQPIKVATQPEL--------QVPGPVENLQAVSTSPTSILITWEPPAYA 554
VA + G S + V +PGP Q + S+ ++W+P
Sbjct: 489 VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPG 548
Query: 555 NGPVQGY--RLFCTEVSTGKEQNI-EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTD 611
P Y F VS + V Y + GL+ T Y A N G +
Sbjct: 549 TLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSP 608
Query: 612 DITVVTLSDVPSAPPQNVSLE-----------------VVNSRSIKVSWLPPPSGTQNGF 654
V D+ S P Q V V+ +++V+W Q F
Sbjct: 609 MSDPVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTW---TVDRQPQF 664
Query: 655 ITGYKIRHRK------TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708
I GY++ +R+ T+ ++ P + L+KG Y +V G S
Sbjct: 665 IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDS 724
Query: 709 NWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPL--NPNIVVRGYIIG-YGV 764
T T E S P + L V + I +SW PP + N +++ Y I G
Sbjct: 725 ESKTVRTTEE--APSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGN 782
Query: 765 GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
+ + VD+ R I L Y + + A +AG GV
Sbjct: 783 ETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 824
Score = 191 bits (484), Expect = 6e-48
Identities = 229/842 (27%), Positives = 332/842 (39%), Gaps = 117/842 (13%)
Query: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
P R + V G+ L C+ G P PTI W K+ + + D R ++LPSG+
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
L R+ G D G Y C ARN A EV +L D F Q P++V
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------FRQNPTDV 142
Query: 250 VAIEGKDAVLEC-CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
V G+ A+LEC G+P P+ W + + I + ++ S+ GG L+ISN D+GMY
Sbjct: 143 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG-KLMISNTRKSDAGMY 201
Query: 309 TCVVT-YKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
TCV T E S AELTV P FL P N E +EF C V G P PTV W K+
Sbjct: 202 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
Query: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
D +P + I LRI + +DEG Y C+AEN G + SA L V P P V
Sbjct: 262 -DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP--PQFVV 318
Query: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN-TTQPGSL- 485
PRD ++ R V P E KGN Q VF+ +EG N QP S
Sbjct: 319 ---RPRD--QIVAQGRTVTF----PCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRC 368
Query: 486 ------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA-----TQPELQVPGPVENL 534
LT+ N++ + A G + ++V P + + GP
Sbjct: 369 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 428
Query: 535 QAV---------STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV-DGLSYK 584
AV +T +I+W + P + R E T + +N+ + D +Y
Sbjct: 429 LAVDGTALLKCKATGDPLPVISWLKEGF-TFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
Query: 585 LEGLKKFTEYS-LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSW 643
E S L G +S + LSD+P PP + V S+ +SW
Sbjct: 488 CVATSSSGETSWSAVLDVTESGATISKN----YDLSDLP-GPPSKPQVTDVTKNSVTLSW 542
Query: 644 LPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFT--GLEKGSQYSFQVSAMTV 701
P GT + Y I + +T+ + L+T GL + Y F V A+
Sbjct: 543 QPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINP 600
Query: 702 NGTGPPS------NWYTAETPENDLDESQVPDQPSSLHVRPQTNCII------MSWTPPL 749
G PS P +D QV + + VR ++ ++WT
Sbjct: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 660
Query: 750 NPNIVVRGYIIGYGVGSPYAET---VRVDSK---QRYYSIERLESSSHYVISLKAFNNAG 803
P ++GY + Y S T +D+K +R + L+ Y I ++ + N
Sbjct: 661 QPQF-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEF 719
Query: 804 EGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL---THDAV 860
+G+ ES T R+ + P PP V + + ++
Sbjct: 720 QGMD-SESKTVRTTEE----------------------APSAPPQSVTVLTVGSYNSTSI 756
Query: 861 RVSWADNSVPKNQK--TSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEF 918
VSW D P +Q E +++ + T F + K+ D S GL P Y
Sbjct: 757 SVSW-DPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIGGLFPGIQYRV 812
Query: 919 SV 920
V
Sbjct: 813 EV 814
Score = 71.6 bits (174), Expect = 5e-12
Identities = 85/341 (24%), Positives = 137/341 (40%), Gaps = 42/341 (12%)
Query: 715 TPENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAE 770
T + D S +P PS V T N + +SW P + YII V + + +
Sbjct: 511 TISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSW-Q 569
Query: 771 TVRVDSKQRYYSIERLESSSHYVISLKAFNNAG--EGVPLYESATTRSITDPTDPVDYYP 828
TV K Y++ L ++ Y+ ++A N G + P+ + T+ I+ P VD+
Sbjct: 570 TVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQ 629
Query: 829 LLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWR-- 886
+ + + L P V LT V+V+W + P+ ++ Y V +R
Sbjct: 630 VQKELGDVLVRLHNP---------VVLTPTTVQVTWTVDRQPQF-----IQGYRVMYRQT 675
Query: 887 TSFSASAKYKSEDT---TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAA 943
+ A++ +++ D T S LK YE V N S + T E A
Sbjct: 676 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735
Query: 944 PTSAPKDLTVIT-REGKPRAVIVSWQPPL--EANGKITAYILFYTLDK-----NIPIDDW 995
P++ P+ +TV+T ++ VSW PP NG I Y ++ ++ N +D
Sbjct: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795
Query: 996 IMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
I I G L Y + A S GVG S+P
Sbjct: 796 IRSVIIG--------GLFPGIQYRVEVAASTSAGVGVKSEP 828
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 208 bits (529), Expect = 3e-53
Identities = 216/819 (26%), Positives = 331/819 (40%), Gaps = 79/819 (9%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + +P D + RG L C AE R P I+W K+G +A ++ + L +G+L
Sbjct: 65 RIVEQPPDLLVSRGEPATLPCRAEG-RPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R +PDEG+Y C A G+ SR A + VA LR F +V +G+
Sbjct: 124 FFPRIVHGRRARPDEGVYTCVAR-NYLGAAASRNASLEVA-VLRDDFRQSPGNVVVAVGE 181
Query: 156 TVLLKC-EVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+L+C G P P++ W+K+ L G + + G L +S D G+Y C A
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGR---ITIRGGKLMMSHTLKSDAGMYVCVA 238
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N A R AEV +L P FL+RP N V + C V G PPP W
Sbjct: 239 SNMAGERESAAAEVMVLERPS------FLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
+ + +L + +Y + +L I +V+ +D G YTCV AS L+V VPP +
Sbjct: 293 KEDG--ELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
Query: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI--------PSDYFQIVGGSNLR 386
P + A + F+C G P P + W K G V+ P+ F + L
Sbjct: 351 TQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLN 410
Query: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPS-SSVLPSAPRDVVPVLVSSRFV 445
I V + D G+Y C A + AG+ A L + ++ V+ P + VL SS ++
Sbjct: 411 ITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWL 470
Query: 446 RLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
P GN Q +V + ++G + T G+L + N++ M +
Sbjct: 471 ------PCRVTGNPQP-SVRWKKDGQWLQGDDLQFKTMANGTLY--IANVQEMDMGFYSC 521
Query: 503 VAYNEWGPGESSQPIKV----------ATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552
VA + G S +K+ T+P PG + SI +TW+P
Sbjct: 522 VAKSSTGEATWSGWLKMREDWGVSPDPPTEPS-SPPGAPSQPVVTEITKNSITLTWKPNP 580
Query: 553 YANGPVQGYRLFCTEVSTGKEQNIEVDGL---SYKLEGLKKFTEYSLRFLAYNRYG-PGV 608
V Y + + G DG+ ++ + GL+ T Y A +G
Sbjct: 581 QTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEP 640
Query: 609 STDDITVVTLSDVPSAPPQN------------VSLE---VVNSRSIKVSW-LPPPSGTQN 652
S V T PS P ++ V L+ V+ R+++VSW + P
Sbjct: 641 SPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQ 700
Query: 653 GFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYT 712
GF +++ + ++ P+ + GL G+Q +V A G G S T
Sbjct: 701 GFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVT 760
Query: 713 AETPENDLDESQVPDQPSSLHVRPQTN-CIIMSWTPPL--NPNIVVRGYIIG-YGVGSPY 768
PE + P Q ++ + N I +SW PPL N V+ Y I G S +
Sbjct: 761 RSIPE---EAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRF 817
Query: 769 AETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP 807
R + L Y + A +AG GVP
Sbjct: 818 HLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVP 856
Score = 107 bits (266), Expect = 1e-22
Identities = 194/853 (22%), Positives = 321/853 (37%), Gaps = 115/853 (13%)
Query: 243 LQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEEVIQLRSKKYS---LLGGSNLLIS 298
+++P +++ G+ A L C G P P+ W + G V +R + LL L
Sbjct: 67 VEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126
Query: 299 NVTDD-----DSGMYTCVV-TYKNENISASAELTVLV-PPWFLNHPSNLYAYESMDIEFE 351
+ D G+YTCV Y S +A L V V F P N+ E
Sbjct: 127 RIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLE 186
Query: 352 CTVS-GKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQ 410
C G P P+V+W K+G + + + G L + +KSD G Y CVA N AG +
Sbjct: 187 CVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246
Query: 411 TSAQ--LIVPKPAI----PSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTV 464
++A +++ +P+ + VL AP + + RL WR K + + T
Sbjct: 247 SAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR-----KEDGELPTG 301
Query: 465 FFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQ------PIK 518
+ D+ L +G++ E T+ VA N G E+S P +
Sbjct: 302 RYEIRSDH-------------SLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQ 348
Query: 519 VATQPELQVPGPVENL----QAVSTSPTSILITWEPPAYANGPVQGYRLFCT-EVSTGKE 573
+ TQP+ Q+ P E++ + P +I E P Q + VS +
Sbjct: 349 LVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ 408
Query: 574 QNIEV----DGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNV 629
NI D Y + + + L + G S D + V L P N
Sbjct: 409 LNITAVQRGDAGYYVCQAVSVAGSILAKALLEIK---GASLDGLPPVILQG-----PANQ 460
Query: 630 SLEVVNSRSI--KVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLE----PNNLWYLF 683
+L + +S + +V+ P PS +R +K + + + L+ N Y+
Sbjct: 461 TLVLGSSVWLPCRVTGNPQPS-----------VRWKKDGQWLQGDDLQFKTMANGTLYIA 509
Query: 684 TGLEKGSQYSFQVSAMTVNGTGPPSNWYTAE-----TPENDLDESQVPDQPSSLHVRPQT 738
E + + A + G S W +P+ + S P PS V T
Sbjct: 510 NVQEMDMGF-YSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEIT 568
Query: 739 -NCIIMSWTPPLNPNIVVRGYIIGYGVGSPYA----ETVRVDSKQRYYSIERLESSSHYV 793
N I ++W P V Y+I SP A TV + +++ L+ ++ Y+
Sbjct: 569 KNSITLTWKPNPQTGAAVTSYVIE--AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYL 626
Query: 794 ISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGV--- 850
++A G P +++P D P P P L V V
Sbjct: 627 FLVRAVGAWGLSEP-------SPVSEPVRTQDSSP---SRPVEDPWRGQQGLAEVAVRLQ 676
Query: 851 QAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTAT-- 908
+ + L ++VSW + V+ + V WR + + D S S +T
Sbjct: 677 EPIVLGPRTLQVSWTVDG-----PVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVL 731
Query: 909 -GLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSW 967
GL P T + V S++ + E AP+ P+ + V ++ VSW
Sbjct: 732 RGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSW 791
Query: 968 QPPL--EANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQAR 1025
+PPL + NG IT Y ++ +++ + + +G + + L +Y + A
Sbjct: 792 EPPLPSQQNGVITEYQIWCLGNES---RFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAA 848
Query: 1026 NSKGVGPLSDPIL 1038
S GVG S P+L
Sbjct: 849 TSAGVGVPSAPVL 861
Score = 37.4 bits (85), Expect = 0.11
Identities = 27/95 (28%), Positives = 36/95 (37%), Gaps = 22/95 (23%)
Query: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNG-------------DVVIPSD-- 375
P + P +L C G+P P + W KNG +++PS
Sbjct: 64 PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123
Query: 376 -YFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNA 409
+ +IV G R DEG Y CVA N G A
Sbjct: 124 FFPRIVHGRRAR------PDEGVYTCVARNYLGAA 152
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 202 bits (513), Expect = 2e-51
Identities = 217/813 (26%), Positives = 328/813 (40%), Gaps = 74/813 (9%)
Query: 47 SDAVTMRGGNVLLDCSAESDRGVPV--IKWKKDGIHLALGMDERKQQLSNGSLLIQNILH 104
S + +RG ++LL+C A GVP I W K G L D+ K + N +L I N+
Sbjct: 265 SSQMVLRGMDLLLECIAS---GVPTPDIAWYKKGGDLP--SDKAKFENFNKALRITNV-- 317
Query: 105 SRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVI 164
+ D G Y C AS GSI T V V +L + +++ G+ L C
Sbjct: 318 ---SEEDSGEYFCLAS-NKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 372
Query: 165 GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISR-LQPGDIGIYRCSARNPASSRTG 223
G P PT+ W N + L P + V +G I R Q +Y+C+ N
Sbjct: 373 GNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNEHGYLLA 430
Query: 224 NEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR 283
N A V +L P R L R + I L+C G P P+ W + + L
Sbjct: 431 N-AFVSVLDVPP--RMLS--PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLD 485
Query: 284 SKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAY 343
Y + +L I + +D G+YTCV T L V P P + A
Sbjct: 486 GGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR 545
Query: 344 ESMDIEFECTVSGKP--VPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCV 401
++ EC V P TV+W+K+ + + + + S L I GV + D+G Y CV
Sbjct: 546 RGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDS-LTIFGVAERDQGSYTCV 604
Query: 402 AENEAGNAQTSAQL-IVPKPAIPSSSVL------PSAPRDVVPVLVSSRFVRLSWRPPAE 454
A E A L ++ A P++ + P PRD+ ++ R VRL+W P
Sbjct: 605 ASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDA 664
Query: 455 AKGNIQTFTVFFSREGDNRERAL---NTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWG-- 509
I + V F E D + + ++ PGS+ V L P Y FRV+A NE G
Sbjct: 665 NNSPITDYVVQF--EEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSS 722
Query: 510 -PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP--PAYANGPVQGYRLFCT 566
P S+ + + P PG V + T ++ ITW P A GP Y +
Sbjct: 723 HPSLPSERYRTSGAPPESNPGDV---KGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWR 779
Query: 567 EVSTGKE-QNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAP 625
T + N+ V G Y + + Y +R A N +G G + + + D P A
Sbjct: 780 RRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAA 839
Query: 626 PQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYK---------IRHRKTTRRGEMETLEP 676
P V + V+NS +I + W S T G + Y+ +++ +++ + +
Sbjct: 840 PTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPG 899
Query: 677 NNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVR- 735
+ L + + L S Y ++ + G GP S TPE VP P VR
Sbjct: 900 DRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEG------VPSAPRRFRVRQ 953
Query: 736 PQTNCIIMSWTPPLNPNIVVRGYIIGY------GVGSPYAETVRVDSKQRYYSIERLESS 789
P I + W P +PN ++ GY + Y VG E Q ++++R +
Sbjct: 954 PNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVE--NFSPNQTKFTVQRTDPV 1011
Query: 790 SHYVISLKAFNNAGEGVPLYESATTRSITDPTD 822
S Y +L A G G E+ T S P +
Sbjct: 1012 SRYRFTLSARTQVGSG----EAVTEESPAPPNE 1040
Score = 154 bits (390), Expect = 5e-37
Identities = 234/1050 (22%), Positives = 399/1050 (38%), Gaps = 148/1050 (14%)
Query: 56 NVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLY 115
N+L++C A+ + P W ++ + D R L+ + + EG Y
Sbjct: 52 NILIECEAKGNPA-PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
Query: 116 QCEASLGDSGSIISRTAKVAVA-GPLRFLSQTESVTAFMGDTVLLKCEVI-GEPMPTIHW 173
QC A G+ +S ++ V+ PL + V G + L+C G P P I W
Sbjct: 111 QCFAR-NKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFW 169
Query: 174 QKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGI-YRCSAR----------NP----- 217
+ + PI D RV +G L S + D+ Y C+AR NP
Sbjct: 170 MSSSME--PITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
Query: 218 ASSRTGNEAEVR----ILSDPGLHRQLYFLQRP----SNVVAIEGKDAVLECCVSGYPPP 269
++ N++ +R + S G+ + P S+ + + G D +LEC SG P P
Sbjct: 228 LTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 287
Query: 270 SFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV 329
W + + K+ + L I+NV+++DSG Y C+ + K +I + + V
Sbjct: 288 DIAWYKKGGDLPSDKAKFENFNKA-LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 330 PPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVV--IPSDYFQIVGGSNLRI 387
P++L+ P NL D C +G P PTV WM NG+ + P + + V G +
Sbjct: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 406
Query: 388 LGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRL 447
S YQC NE G +A + SVL PR + P R +
Sbjct: 407 RDTQISSRAVYQCNTSNEHGYLLANAFV----------SVLDVPPRMLSPRNQLIRVILY 456
Query: 448 S-WRPPAEAKGN-IQTFTVFFSREGDNRERA-LNTTQPGSLQLTVGNLKPEAMYTFRVVA 504
+ R G+ I T F + +G N + + + GSL++ + + + +YT VA
Sbjct: 457 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYT--CVA 514
Query: 505 YNEWGPGES------SQPIKVATQPELQVP--GPVENLQA-VSTSPT-SILITW---EPP 551
N G E+ P ++ PE QV G L+ V P+ + ++W + P
Sbjct: 515 TNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 574
Query: 552 AYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTD 611
Y G E D L+ + G+ + + S +A ++
Sbjct: 575 LY----------------IGNRMKKEDDSLT--IFGVAERDQGSYTCVASTELDQDLAKA 616
Query: 612 DITVVTLSDVPS-----------APPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660
+TV+ P+ P+++ L + RS++++W+ P N IT Y +
Sbjct: 617 YLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWI--PGDANNSPITDYVV 674
Query: 661 RHRKTTRRGEM---ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPE 717
+ + + + + P ++ L Y F+V A+ G+ PS P
Sbjct: 675 QFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPS------LPS 728
Query: 718 NDLDESQVPDQPSSLHVR---PQTNCIIMSWTP-----PLNPNIVVRGYIIGYGVGSPYA 769
S P + + V+ + N + ++WTP PN+ YI+ +
Sbjct: 729 ERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNL---RYIVKWRRRETRE 785
Query: 770 ETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPL 829
V Y + + Y I ++A N+ G+G +P + Y
Sbjct: 786 AWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKG------------PEPESVIGYSG- 832
Query: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLY-TVRWRTS 888
+D+P + P V+ + A+ + W N V + ++R Y WR S
Sbjct: 833 -EDYPRAA---------PTEVKVRVMNSTAISLQW--NRVYSDTVQGQLREYRAYYWRES 880
Query: 889 FSASAKYKSEDTTSLSYTATGLK-------PNTMYEFSVMVTKNRRSSTWSMTAHATTYE 941
+ S+ S+ L+ P + Y+ ++V R S T TT E
Sbjct: 881 SLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPE 940
Query: 942 AAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETIS 1001
P SAP+ V R+ + + W P NG + Y L Y + I+E S
Sbjct: 941 GVP-SAPRRFRV--RQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFS 997
Query: 1002 GDRLTHQIMDLNLDTMYYFRIQARNSKGVG 1031
++ + + + Y F + AR G G
Sbjct: 998 PNQTKFTVQRTDPVSRYRFTLSARTQVGSG 1027
Score = 77.4 bits (189), Expect = 9e-14
Identities = 80/292 (27%), Positives = 112/292 (38%), Gaps = 45/292 (15%)
Query: 155 DTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVV-LPSGALQISRLQPGD----IGI 209
D +L++CE G P P+ HW +N + I D RV + SG L I G G
Sbjct: 51 DNILIECEAKGNPAPSFHWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE 109
Query: 210 YRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLEC-CVSGYPP 268
Y+C ARN + N +++ P L+ + VV EG L+C G P
Sbjct: 110 YQCFARNKFGTALSNRIRLQVSKSP-----LWPKENLDPVVVQEGAPLTLQCNPPPGLPS 164
Query: 269 PSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV-TDDDSGMYTCVVTYK-NENISASAELT 326
P W+ + K+ S +L SNV D Y+C + I T
Sbjct: 165 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 224
Query: 327 VLV---PPW----FLNHP----------------------SNLYAYESMDIEFECTVSGK 357
+ V P+ NHP S+ MD+ EC SG
Sbjct: 225 LKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGV 284
Query: 358 PVPTVNWMKNGDVVIPSDYFQIVG-GSNLRILGVVKSDEGFYQCVAENEAGN 408
P P + W K G +PSD + LRI V + D G Y C+A N+ G+
Sbjct: 285 PTPDIAWYKKGG-DLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGS 335
Score = 33.9 bits (76), Expect = 1.2
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 9/81 (11%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPV-IKWKKDGIHLALGMDERKQQLSNGSLLI 99
R P D V RG V L+C + D + + + W KD L +G +K+ + SL I
Sbjct: 534 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE---DDSLTI 590
Query: 100 QNILHSRHHKPDEGLYQCEAS 120
+ + D+G Y C AS
Sbjct: 591 FGVA-----ERDQGSYTCVAS 606
Score = 33.5 bits (75), Expect = 1.5
Identities = 45/198 (22%), Positives = 80/198 (40%), Gaps = 17/198 (8%)
Query: 847 PVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYK--SEDTTSLS 904
P ++ L +VR++W +P + S + Y V++ + S+ S++
Sbjct: 642 PRDLELTDLAERSVRLTW----IPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVN 697
Query: 905 YTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA-TTYEAAPTSAPKDLTVITREG-KPRA 962
L P Y+F V+ SS S+ + T A P S P D + EG +
Sbjct: 698 SAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGD---VKGEGTRKNN 754
Query: 963 VIVSWQP--PLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF 1020
+ ++W P A G YI+ + + + W T+ G R + + + Y
Sbjct: 755 MEITWTPMNATSAFGPNLRYIVKWR--RRETREAWNNVTVWGSR--YVVGQTPVYVPYEI 810
Query: 1021 RIQARNSKGVGPLSDPIL 1038
R+QA N G GP + ++
Sbjct: 811 RVQAENDFGKGPEPESVI 828
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 201 bits (512), Expect = 3e-51
Identities = 186/722 (25%), Positives = 301/722 (41%), Gaps = 81/722 (11%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
F PSD + G +++C P I WKKDG L D++ ++++ G L+I
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 188
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
+ K D G Y C + G S A++ V F+ + ++ + D+
Sbjct: 189 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
KCE G+P+PT+ W+K+ +L SR + L+I ++ GD+G Y C A N
Sbjct: 243 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 220 SRTGNEA-EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GE 277
+ V++ S+P +F+ +P + V G+ +C +G P P+ W R G
Sbjct: 299 KAEASATLTVQVGSEPP-----HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353
Query: 278 EVIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL--- 328
+ + S ++S+ +L I+NV D G Y C +I A L V
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
Query: 329 ---VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSN 384
PP P N C +G PVPT+ W K+G +V D + +
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
Query: 385 LRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVP 437
L+I D G Y C+A +G A SA + V + +P +++PSAP
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533
Query: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPE 495
VS V LSW+P + ++ + F G + + + + + LKP
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPN 591
Query: 496 AMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552
A+Y F V A N +G P + S P+K TQ L V++ Q ++L P
Sbjct: 592 AIYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 553 YANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLK 589
++ +QGY++ + E D L ++ + L+
Sbjct: 650 LSSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 590 KFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPP 647
K Y ++ + G ++ TL + PSAPPQ V++ N +I VSW PPP
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 766
Query: 648 SGTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706
TQNG + YK+ TR +T++ + + L G +YS +V+A T G+G
Sbjct: 767 EDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Query: 707 PS 708
S
Sbjct: 827 KS 828
Score = 192 bits (487), Expect = 3e-48
Identities = 215/837 (25%), Positives = 320/837 (38%), Gaps = 111/837 (13%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + PSD + +G L+C AE R P I+W K G + D+ + L +GSL
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R +PDEG+Y C A G +S A + VA LR F V +G+
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 146
Query: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+++C+ G P PTI W+K D +P+ + + G L I+ + D G Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N R AE+ +L P F++RPSN+ A +C G P P+ W
Sbjct: 204 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV---PP 331
+ + +L +Y + L I VT D G YTCV ASA LTV V PP
Sbjct: 258 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGS 383
F+ P + + F+C +G P P + W + G + Y F +
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVV 436
+L I V +SD G+Y C N AG+ T A L V P P I V + D
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 437 PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLK 493
VL A G+ T+ + ++G ++ + + G LQ+ L
Sbjct: 436 FVL------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 494 PEAMYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPT 542
YT +A G S I+V T P L +P + S
Sbjct: 483 DTGRYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRN 539
Query: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLR 597
++ ++W+P + Y + ++G +N++ + + ++GLK Y
Sbjct: 540 TVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFL 597
Query: 598 FLAYNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKV 641
A N YG P +D + T L + V E V++S SI+V
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 642 SWLPPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQ 695
W Q+ +I GYKI +R + GE E P + L KG Y +
Sbjct: 658 HW---TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIK 714
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIV 754
G S A+T E + P Q ++ I++SW PP P
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDT 769
Query: 755 VRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
G + Y G + Y VD I L Y + + A AG GV
Sbjct: 770 QNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Score = 158 bits (399), Expect = 4e-38
Identities = 226/858 (26%), Positives = 329/858 (38%), Gaps = 121/858 (14%)
Query: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
P R + + G+ L C+ G P PTI W K + + D R ++LPSG+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
L R+ G D G+Y C ARN + A EV IL D F Q PS+V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 140
Query: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
+ G+ AV+EC G+P P+ +W + + + ++ ++ GG L+I+ D+G Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 199
Query: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
CV T E S AELTVL P F+ PSNL EF+C G PVPTV W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
D +P ++I L+I V D G Y CVAEN G A+ SA L V + P V
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477
+ PRD V L R V EA GN Q +F+ REG
Sbjct: 319 V--KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528
+ +Q G L +T Y + + AY E + +P V Q
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 423
Query: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586
GPV AV T S + T P G L T+ S K+ V + Y KL
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
++T + ++ +G V T L +PSA P + V+
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 539
Query: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695
++ +SW P+ T Y I +T+ N GL+ + Y F
Sbjct: 540 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 597
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743
V A G PS ++ L SQ D + LH+ T + I +
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796
WT + ++GY I Y G+ + E+ VR +K I L +Y I
Sbjct: 658 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 715
Query: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
+ F N +G + + L++ P++ PP GV
Sbjct: 716 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 752
Query: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
+ A+ VSW P++ + V+ Y V + + K+ D ++ S L P
Sbjct: 753 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 810
Query: 915 MYEFSVMVTKNRRSSTWS 932
Y V + S S
Sbjct: 811 RYSVEVAASTGAGSGVKS 828
Score = 74.3 bits (181), Expect = 8e-13
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)
Query: 716 PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771
P D + +P PS V + N + +SW P LN YII + GS + +T
Sbjct: 515 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 573
Query: 772 VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829
V + K +I+ L+ ++ Y+ ++A N G P + + T+ + + VD+ +
Sbjct: 574 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 633
Query: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889
+ +V L P + L+ ++ V W +Q++ ++ Y + +R S
Sbjct: 634 QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 679
Query: 890 SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
+ + ++ S L+ YE N S A T E AP
Sbjct: 680 ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 739
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002
++ P+ +TV +G A++VSWQPP E NG + Y ++ ++ I +T+ G
Sbjct: 740 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 796
Query: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
+ I L Y + A G G S+P
Sbjct: 797 STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 201 bits (512), Expect = 3e-51
Identities = 186/722 (25%), Positives = 301/722 (41%), Gaps = 81/722 (11%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
F PSD + G +++C P I WKKDG L D++ ++++ G L+I
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 188
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
+ K D G Y C + G S A++ V F+ + ++ + D+
Sbjct: 189 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
KCE G+P+PT+ W+K+ +L SR + L+I ++ GD+G Y C A N
Sbjct: 243 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 220 SRTGNEA-EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GE 277
+ V++ S+P +F+ +P + V G+ +C +G P P+ W R G
Sbjct: 299 KAEASATLTVQVGSEPP-----HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353
Query: 278 EVIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL--- 328
+ + S ++S+ +L I+NV D G Y C +I A L V
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
Query: 329 ---VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSN 384
PP P N C +G PVPT+ W K+G +V D + +
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
Query: 385 LRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVP 437
L+I D G Y C+A +G A SA + V + +P +++PSAP
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533
Query: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPE 495
VS V LSW+P + ++ + F G + + + + + LKP
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPN 591
Query: 496 AMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552
A+Y F V A N +G P + S P+K TQ L V++ Q ++L P
Sbjct: 592 AIYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 553 YANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLK 589
++ +QGY++ + E D L ++ + L+
Sbjct: 650 LSSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 590 KFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPP 647
K Y ++ + G ++ TL + PSAPPQ V++ N +I VSW PPP
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 766
Query: 648 SGTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706
TQNG + YK+ TR +T++ + + L G +YS +V+A T G+G
Sbjct: 767 EDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Query: 707 PS 708
S
Sbjct: 827 KS 828
Score = 192 bits (487), Expect = 3e-48
Identities = 215/837 (25%), Positives = 320/837 (38%), Gaps = 111/837 (13%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + PSD + +G L+C AE R P I+W K G + D+ + L +GSL
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R +PDEG+Y C A G +S A + VA LR F V +G+
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 146
Query: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+++C+ G P PTI W+K D +P+ + + G L I+ + D G Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N R AE+ +L P F++RPSN+ A +C G P P+ W
Sbjct: 204 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV---PP 331
+ + +L +Y + L I VT D G YTCV ASA LTV V PP
Sbjct: 258 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGS 383
F+ P + + F+C +G P P + W + G + Y F +
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVV 436
+L I V +SD G+Y C N AG+ T A L V P P I V + D
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 437 PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLK 493
VL A G+ T+ + ++G ++ + + G LQ+ L
Sbjct: 436 FVL------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 494 PEAMYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPT 542
YT +A G S I+V T P L +P + S
Sbjct: 483 DTGRYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRN 539
Query: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLR 597
++ ++W+P + Y + ++G +N++ + + ++GLK Y
Sbjct: 540 TVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFL 597
Query: 598 FLAYNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKV 641
A N YG P +D + T L + V E V++S SI+V
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 642 SWLPPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQ 695
W Q+ +I GYKI +R + GE E P + L KG Y +
Sbjct: 658 HW---TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIK 714
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIV 754
G S A+T E + P Q ++ I++SW PP P
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDT 769
Query: 755 VRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
G + Y G + Y VD I L Y + + A AG GV
Sbjct: 770 QNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Score = 158 bits (399), Expect = 4e-38
Identities = 226/858 (26%), Positives = 329/858 (38%), Gaps = 121/858 (14%)
Query: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
P R + + G+ L C+ G P PTI W K + + D R ++LPSG+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
L R+ G D G+Y C ARN + A EV IL D F Q PS+V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 140
Query: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
+ G+ AV+EC G+P P+ +W + + + ++ ++ GG L+I+ D+G Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 199
Query: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
CV T E S AELTVL P F+ PSNL EF+C G PVPTV W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
D +P ++I L+I V D G Y CVAEN G A+ SA L V + P V
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477
+ PRD V L R V EA GN Q +F+ REG
Sbjct: 319 V--KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528
+ +Q G L +T Y + + AY E + +P V Q
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 423
Query: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586
GPV AV T S + T P G L T+ S K+ V + Y KL
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
++T + ++ +G V T L +PSA P + V+
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 539
Query: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695
++ +SW P+ T Y I +T+ N GL+ + Y F
Sbjct: 540 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 597
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743
V A G PS ++ L SQ D + LH+ T + I +
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796
WT + ++GY I Y G+ + E+ VR +K I L +Y I
Sbjct: 658 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 715
Query: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
+ F N +G + + L++ P++ PP GV
Sbjct: 716 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 752
Query: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
+ A+ VSW P++ + V+ Y V + + K+ D ++ S L P
Sbjct: 753 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 810
Query: 915 MYEFSVMVTKNRRSSTWS 932
Y V + S S
Sbjct: 811 RYSVEVAASTGAGSGVKS 828
Score = 74.3 bits (181), Expect = 8e-13
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)
Query: 716 PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771
P D + +P PS V + N + +SW P LN YII + GS + +T
Sbjct: 515 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 573
Query: 772 VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829
V + K +I+ L+ ++ Y+ ++A N G P + + T+ + + VD+ +
Sbjct: 574 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 633
Query: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889
+ +V L P + L+ ++ V W +Q++ ++ Y + +R S
Sbjct: 634 QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 679
Query: 890 SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
+ + ++ S L+ YE N S A T E AP
Sbjct: 680 ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 739
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002
++ P+ +TV +G A++VSWQPP E NG + Y ++ ++ I +T+ G
Sbjct: 740 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 796
Query: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
+ I L Y + A G G S+P
Sbjct: 797 STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 201 bits (512), Expect = 3e-51
Identities = 186/722 (25%), Positives = 301/722 (41%), Gaps = 81/722 (11%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
F PSD + G +++C P I WKKDG L D++ ++++ G L+I
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 188
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
+ K D G Y C + G S A++ V F+ + ++ + D+
Sbjct: 189 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
KCE G+P+PT+ W+K+ +L SR + L+I ++ GD+G Y C A N
Sbjct: 243 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 220 SRTGNEA-EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GE 277
+ V++ S+P +F+ +P + V G+ +C +G P P+ W R G
Sbjct: 299 KAEASATLTVQVGSEPP-----HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353
Query: 278 EVIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL--- 328
+ + S ++S+ +L I+NV D G Y C +I A L V
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
Query: 329 ---VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSN 384
PP P N C +G PVPT+ W K+G +V D + +
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
Query: 385 LRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVP 437
L+I D G Y C+A +G A SA + V + +P +++PSAP
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533
Query: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPE 495
VS V LSW+P + ++ + F G + + + + + LKP
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPN 591
Query: 496 AMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552
A+Y F V A N +G P + S P+K TQ L V++ Q ++L P
Sbjct: 592 AIYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 553 YANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLK 589
++ +QGY++ + E D L ++ + L+
Sbjct: 650 LSSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 590 KFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPP 647
K Y ++ + G ++ TL + PSAPPQ V++ N +I VSW PPP
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 766
Query: 648 SGTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706
TQNG + YK+ TR +T++ + + L G +YS +V+A T G+G
Sbjct: 767 EDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Query: 707 PS 708
S
Sbjct: 827 KS 828
Score = 192 bits (487), Expect = 3e-48
Identities = 215/837 (25%), Positives = 320/837 (38%), Gaps = 111/837 (13%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + PSD + +G L+C AE R P I+W K G + D+ + L +GSL
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R +PDEG+Y C A G +S A + VA LR F V +G+
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 146
Query: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+++C+ G P PTI W+K D +P+ + + G L I+ + D G Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N R AE+ +L P F++RPSN+ A +C G P P+ W
Sbjct: 204 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV---PP 331
+ + +L +Y + L I VT D G YTCV ASA LTV V PP
Sbjct: 258 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGS 383
F+ P + + F+C +G P P + W + G + Y F +
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVV 436
+L I V +SD G+Y C N AG+ T A L V P P I V + D
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 437 PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLK 493
VL A G+ T+ + ++G ++ + + G LQ+ L
Sbjct: 436 FVL------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 494 PEAMYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPT 542
YT +A G S I+V T P L +P + S
Sbjct: 483 DTGRYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRN 539
Query: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLR 597
++ ++W+P + Y + ++G +N++ + + ++GLK Y
Sbjct: 540 TVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFL 597
Query: 598 FLAYNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKV 641
A N YG P +D + T L + V E V++S SI+V
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 642 SWLPPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQ 695
W Q+ +I GYKI +R + GE E P + L KG Y +
Sbjct: 658 HW---TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIK 714
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIV 754
G S A+T E + P Q ++ I++SW PP P
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDT 769
Query: 755 VRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
G + Y G + Y VD I L Y + + A AG GV
Sbjct: 770 QNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Score = 158 bits (399), Expect = 4e-38
Identities = 226/858 (26%), Positives = 329/858 (38%), Gaps = 121/858 (14%)
Query: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
P R + + G+ L C+ G P PTI W K + + D R ++LPSG+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
L R+ G D G+Y C ARN + A EV IL D F Q PS+V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 140
Query: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
+ G+ AV+EC G+P P+ +W + + + ++ ++ GG L+I+ D+G Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 199
Query: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
CV T E S AELTVL P F+ PSNL EF+C G PVPTV W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
D +P ++I L+I V D G Y CVAEN G A+ SA L V + P V
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477
+ PRD V L R V EA GN Q +F+ REG
Sbjct: 319 V--KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528
+ +Q G L +T Y + + AY E + +P V Q
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 423
Query: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586
GPV AV T S + T P G L T+ S K+ V + Y KL
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
++T + ++ +G V T L +PSA P + V+
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 539
Query: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695
++ +SW P+ T Y I +T+ N GL+ + Y F
Sbjct: 540 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 597
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743
V A G PS ++ L SQ D + LH+ T + I +
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796
WT + ++GY I Y G+ + E+ VR +K I L +Y I
Sbjct: 658 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 715
Query: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
+ F N +G + + L++ P++ PP GV
Sbjct: 716 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 752
Query: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
+ A+ VSW P++ + V+ Y V + + K+ D ++ S L P
Sbjct: 753 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 810
Query: 915 MYEFSVMVTKNRRSSTWS 932
Y V + S S
Sbjct: 811 RYSVEVAASTGAGSGVKS 828
Score = 74.3 bits (181), Expect = 8e-13
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)
Query: 716 PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771
P D + +P PS V + N + +SW P LN YII + GS + +T
Sbjct: 515 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 573
Query: 772 VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829
V + K +I+ L+ ++ Y+ ++A N G P + + T+ + + VD+ +
Sbjct: 574 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 633
Query: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889
+ +V L P + L+ ++ V W +Q++ ++ Y + +R S
Sbjct: 634 QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 679
Query: 890 SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
+ + ++ S L+ YE N S A T E AP
Sbjct: 680 ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 739
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002
++ P+ +TV +G A++VSWQPP E NG + Y ++ ++ I +T+ G
Sbjct: 740 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 796
Query: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
+ I L Y + A G G S+P
Sbjct: 797 STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 201 bits (512), Expect = 3e-51
Identities = 186/722 (25%), Positives = 301/722 (41%), Gaps = 81/722 (11%)
Query: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
F PSD + G +++C P I WKKDG L D++ ++++ G L+I
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 188
Query: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
+ K D G Y C + G S A++ V F+ + ++ + D+
Sbjct: 189 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
Query: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
KCE G+P+PT+ W+K+ +L SR + L+I ++ GD+G Y C A N
Sbjct: 243 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 220 SRTGNEA-EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GE 277
+ V++ S+P +F+ +P + V G+ +C +G P P+ W R G
Sbjct: 299 KAEASATLTVQVGSEPP-----HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353
Query: 278 EVIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL--- 328
+ + S ++S+ +L I+NV D G Y C +I A L V
Sbjct: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
Query: 329 ---VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSN 384
PP P N C +G PVPT+ W K+G +V D + +
Sbjct: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
Query: 385 LRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVP 437
L+I D G Y C+A +G A SA + V + +P +++PSAP
Sbjct: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533
Query: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPE 495
VS V LSW+P + ++ + F G + + + + + LKP
Sbjct: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPN 591
Query: 496 AMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552
A+Y F V A N +G P + S P+K TQ L V++ Q ++L P
Sbjct: 592 AIYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
Query: 553 YANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLK 589
++ +QGY++ + E D L ++ + L+
Sbjct: 650 LSSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
Query: 590 KFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPP 647
K Y ++ + G ++ TL + PSAPPQ V++ N +I VSW PPP
Sbjct: 707 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 766
Query: 648 SGTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706
TQNG + YK+ TR +T++ + + L G +YS +V+A T G+G
Sbjct: 767 EDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Query: 707 PS 708
S
Sbjct: 827 KS 828
Score = 192 bits (487), Expect = 3e-48
Identities = 215/837 (25%), Positives = 320/837 (38%), Gaps = 111/837 (13%)
Query: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
R + PSD + +G L+C AE R P I+W K G + D+ + L +GSL
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
I+H R +PDEG+Y C A G +S A + VA LR F V +G+
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 146
Query: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
+++C+ G P PTI W+K D +P+ + + G L I+ + D G Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
N R AE+ +L P F++RPSN+ A +C G P P+ W
Sbjct: 204 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV---PP 331
+ + +L +Y + L I VT D G YTCV ASA LTV V PP
Sbjct: 258 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Query: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGS 383
F+ P + + F+C +G P P + W + G + Y F +
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVV 436
+L I V +SD G+Y C N AG+ T A L V P P I V + D
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 437 PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLK 493
VL A G+ T+ + ++G ++ + + G LQ+ L
Sbjct: 436 FVL------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 494 PEAMYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPT 542
YT +A G S I+V T P L +P + S
Sbjct: 483 DTGRYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRN 539
Query: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLR 597
++ ++W+P + Y + ++G +N++ + + ++GLK Y
Sbjct: 540 TVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFL 597
Query: 598 FLAYNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKV 641
A N YG P +D + T L + V E V++S SI+V
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 642 SWLPPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQ 695
W Q+ +I GYKI +R + GE E P + L KG Y +
Sbjct: 658 HW---TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIK 714
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIV 754
G S A+T E + P Q ++ I++SW PP P
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDT 769
Query: 755 VRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
G + Y G + Y VD I L Y + + A AG GV
Sbjct: 770 QNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
Score = 158 bits (399), Expect = 4e-38
Identities = 226/858 (26%), Positives = 329/858 (38%), Gaps = 121/858 (14%)
Query: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
P R + + G+ L C+ G P PTI W K + + D R ++LPSG+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
L R+ G D G+Y C ARN + A EV IL D F Q PS+V
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 140
Query: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
+ G+ AV+EC G+P P+ +W + + + ++ ++ GG L+I+ D+G Y
Sbjct: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 199
Query: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
CV T E S AELTVL P F+ PSNL EF+C G PVPTV W K+
Sbjct: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
Query: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
D +P ++I L+I V D G Y CVAEN G A+ SA L V + P V
Sbjct: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477
+ PRD V L R V EA GN Q +F+ REG
Sbjct: 319 V--KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528
+ +Q G L +T Y + + AY E + +P V Q
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 423
Query: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586
GPV AV T S + T P G L T+ S K+ V + Y KL
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
++T + ++ +G V T L +PSA P + V+
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 539
Query: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695
++ +SW P+ T Y I +T+ N GL+ + Y F
Sbjct: 540 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 597
Query: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743
V A G PS ++ L SQ D + LH+ T + I +
Sbjct: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
Query: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796
WT + ++GY I Y G+ + E+ VR +K I L +Y I
Sbjct: 658 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 715
Query: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
+ F N +G + + L++ P++ PP GV
Sbjct: 716 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 752
Query: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
+ A+ VSW P++ + V+ Y V + + K+ D ++ S L P
Sbjct: 753 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 810
Query: 915 MYEFSVMVTKNRRSSTWS 932
Y V + S S
Sbjct: 811 RYSVEVAASTGAGSGVKS 828
Score = 74.3 bits (181), Expect = 8e-13
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)
Query: 716 PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771
P D + +P PS V + N + +SW P LN YII + GS + +T
Sbjct: 515 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 573
Query: 772 VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829
V + K +I+ L+ ++ Y+ ++A N G P + + T+ + + VD+ +
Sbjct: 574 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 633
Query: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889
+ +V L P + L+ ++ V W +Q++ ++ Y + +R S
Sbjct: 634 QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 679
Query: 890 SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
+ + ++ S L+ YE N S A T E AP
Sbjct: 680 ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 739
Query: 945 TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002
++ P+ +TV +G A++VSWQPP E NG + Y ++ ++ I +T+ G
Sbjct: 740 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 796
Query: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
+ I L Y + A G G S+P
Sbjct: 797 STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,395,072
Number of Sequences: 37866
Number of extensions: 3244532
Number of successful extensions: 21596
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 324
Number of HSP's successfully gapped in prelim test: 674
Number of HSP's that attempted gapping in prelim test: 9508
Number of HSP's gapped (non-prelim): 5287
length of query: 1447
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1332
effective length of database: 13,892,928
effective search space: 18505380096
effective search space used: 18505380096
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.