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Search of human proteins with 156142184
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156142184 ankyrin repeat domain 39 [Homo sapiens]
(183 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156142184 ankyrin repeat domain 39 [Homo sapiens] 381 e-106
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 99 3e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 86 1e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 82 3e-16
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 82 3e-16
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 82 3e-16
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 82 3e-16
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 82 3e-16
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 80 1e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 80 1e-15
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 80 1e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 80 1e-15
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 79 2e-15
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 79 2e-15
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 76 2e-14
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 76 2e-14
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 75 2e-14
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 75 2e-14
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 75 2e-14
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 75 2e-14
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 75 4e-14
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 74 9e-14
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 74 9e-14
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 74 9e-14
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 74 9e-14
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 74 9e-14
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 74 9e-14
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 74 9e-14
gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens] 74 9e-14
gi|42734375 ankyrin repeat and sterile alpha motif domain contai... 74 9e-14
>gi|156142184 ankyrin repeat domain 39 [Homo sapiens]
Length = 183
Score = 381 bits (979), Expect = e-106
Identities = 183/183 (100%), Positives = 183/183 (100%)
Query: 1 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP 60
MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP
Sbjct: 1 MATPRPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQP 60
Query: 61 DSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHG 120
DSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHG
Sbjct: 61 DSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHG 120
Query: 121 SNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDL 180
SNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDL
Sbjct: 121 SNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDL 180
Query: 181 LSS 183
LSS
Sbjct: 181 LSS 183
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 98.6 bits (244), Expect = 3e-21
Identities = 64/168 (38%), Positives = 88/168 (52%), Gaps = 10/168 (5%)
Query: 5 RPCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAG 64
R CA G +A V+ E+ + A NGD+ RVK L+ E + D+AG
Sbjct: 4 RRCAGGGAACASAAAEAVEPAAREL------FEACRNGDVERVKRLVTP-EKVNSRDTAG 56
Query: 65 Y--TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
T LH+A+ G V ++LL++GA A+ GG LH A GH E+ LLL HG++
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGAD 116
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDL 170
P D+ T LH+AA +G D+C +LLQH A IR+ R A DL
Sbjct: 117 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHG-AEPTIRNTDGRTALDL 163
Score = 82.0 bits (201), Expect = 3e-16
Identities = 59/168 (35%), Positives = 88/168 (52%), Gaps = 9/168 (5%)
Query: 22 VQQTLEE------MDFERGIWSAALNGDLGRVKHLIQ-KAEDPSQPDSAGYTALHYASRN 74
VQQ L+E + +R + AA GD+ VK L ++ + + T LH+A+
Sbjct: 477 VQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY 536
Query: 75 GHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSL 134
+V ++LL+ GA A+ GG LH A GH E+A LL+ HG+ V D T L
Sbjct: 537 NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPL 596
Query: 135 HKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLL-PCNSDLRDLL 181
H+AA +G +IC LLLQH A ++R DL+ ++D++DLL
Sbjct: 597 HEAAAKGKYEICKLLLQHG-ADPTKKNRDGNTPLDLVKDGDTDIQDLL 643
Score = 75.1 bits (183), Expect = 3e-14
Identities = 49/154 (31%), Positives = 83/154 (53%), Gaps = 5/154 (3%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAK 89
+ + AA G L RVK L ++ + D+ G T LH A+ + V ++LL+ GA
Sbjct: 646 DAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD 704
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
+AQ GG LH A+ GH ++A LL+ + + D T LH+AA++G +C+LL
Sbjct: 705 VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL 764
Query: 150 LQHSPALKAIRDRKARLACDLLPCNSDLRDLLSS 183
L H A +++++ + DL+ + D+ LL++
Sbjct: 765 LAHG-ADPTLKNQEGQTPLDLVSAD-DVSALLTA 796
Score = 67.0 bits (162), Expect = 9e-12
Identities = 33/90 (36%), Positives = 52/90 (57%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L++K + ++ T LH AS H V + +++ AK +A + G T+LHRA+YCGH
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAE 139
+ RLLLS+G +P ++ G T+L E
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNE 475
Score = 62.8 bits (151), Expect = 2e-10
Identities = 46/149 (30%), Positives = 73/149 (48%), Gaps = 10/149 (6%)
Query: 13 CSHPSAV--LGVQQTLEEMDFE---RGIWSAALNGDLGRVK-HLIQKAEDPSQPDSAGYT 66
C + SA+ Q E + +E + AA D+ R+K HL + + P + T
Sbjct: 308 CHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHE-T 366
Query: 67 ALHYASRNGH---YAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
ALH A+ + + +C+ LL GA + +T T LH AS H ++ +++ H +
Sbjct: 367 ALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKV 426
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+D+ G TSLH+AA GH C LLL +
Sbjct: 427 NALDNLGQTSLHRAAYCGHLQTCRLLLSY 455
Score = 61.6 bits (148), Expect = 4e-10
Identities = 38/112 (33%), Positives = 54/112 (48%), Gaps = 1/112 (0%)
Query: 61 DSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHG 120
D T LH A+ + Q LL+ GA A+ G LH A GH E+ LL+ HG
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 121 SNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLP 172
+ +D T LH+AA + ++CSLLL + A + + + A DL P
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG-ADPTLLNCHNKSAIDLAP 318
Score = 48.5 bits (114), Expect = 3e-06
Identities = 39/144 (27%), Positives = 61/144 (42%), Gaps = 23/144 (15%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRN------GHYAVCQFLLESG---- 87
AA+ G + L+Q +P+ ++ G TAL A + G Y + LLES
Sbjct: 131 AAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE-LLESARSGN 189
Query: 88 ------------AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLH 135
C A +T LH A+ +I +LLL HG++ D + LH
Sbjct: 190 EEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLH 249
Query: 136 KAAERGHGDICSLLLQHSPALKAI 159
A GH ++ LL++H + A+
Sbjct: 250 NACSYGHYEVTELLVKHGACVNAM 273
Score = 48.5 bits (114), Expect = 3e-06
Identities = 27/81 (33%), Positives = 41/81 (50%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+ L+Q D D LH A GHY V + L++ GA +A T LH A+
Sbjct: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286
Query: 107 CGHTEIARLLLSHGSNPRVVD 127
E+ LLLS+G++P +++
Sbjct: 287 KNRVEVCSLLLSYGADPTLLN 307
Score = 42.4 bits (98), Expect = 2e-04
Identities = 41/166 (24%), Positives = 56/166 (33%), Gaps = 54/166 (32%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V++L+Q D D G LH A GHY V + L++ GA + T LH A+
Sbjct: 542 VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601
Query: 107 CGHTEIARLLLSH----------GSNPRVVDDDG-------------------------- 130
G EI +LLL H G+ P + DG
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARV 661
Query: 131 ------------------MTSLHKAAERGHGDICSLLLQHSPALKA 158
T LH AA + ++ LLQH + A
Sbjct: 662 KKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
Score = 40.8 bits (94), Expect = 7e-04
Identities = 24/70 (34%), Positives = 38/70 (54%), Gaps = 5/70 (7%)
Query: 93 QTHGGATALHRAS---YCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
QTH TALH A+ Y +I LLL G+N + +T LH A+E+ H D+ ++
Sbjct: 362 QTH--ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVV 419
Query: 150 LQHSPALKAI 159
++H + A+
Sbjct: 420 VKHEAKVNAL 429
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 86.3 bits (212), Expect = 1e-17
Identities = 61/167 (36%), Positives = 85/167 (50%), Gaps = 14/167 (8%)
Query: 6 PCADGPCCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY 65
P A GP P+ +++ LE A NGD+ RVK L+ A + + D AG
Sbjct: 167 PGAAGPGTGVPAVSGALRELLE----------ACRNGDVSRVKRLVDAA-NVNAKDMAGR 215
Query: 66 TA--LHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
+ LH+A+ G V + LL+ GA A+ GG LH A GH E+ LLL G++P
Sbjct: 216 KSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADP 275
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDL 170
D+ T LH+AA +G D+C +LLQH A IR+ + A DL
Sbjct: 276 NARDNWNYTPLHEAAIKGKIDVCIVLLQHG-ADPNIRNTDGKSALDL 321
Score = 80.5 bits (197), Expect = 7e-16
Identities = 60/169 (35%), Positives = 88/169 (52%), Gaps = 11/169 (6%)
Query: 22 VQQTLEEM------DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASR 73
VQQ L E D + + A+ GDL VK L +++ + D G T LH+A+
Sbjct: 635 VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAG 693
Query: 74 NGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTS 133
+V ++LL GA A+ GG LH A GH E+A LL+ HG++ V D T
Sbjct: 694 YNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753
Query: 134 LHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLL-PCNSDLRDLL 181
LH+AA +G +IC LLL+H A ++R DL+ ++D++DLL
Sbjct: 754 LHEAAAKGKYEICKLLLKHG-ADPTKKNRDGNTPLDLVKEGDTDIQDLL 801
Score = 75.9 bits (185), Expect = 2e-14
Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 5/152 (3%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGY--TALHYASRNGHYAVCQFLLESGAK 89
+ + AA G L RV+ L E+ + D+ G T LH A+ + V ++LLE GA
Sbjct: 804 DAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
+AQ GG LH A+ GH +IA LL+ + + D T LH+AA++G +C+LL
Sbjct: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922
Query: 150 LQHSPALKAIRDRKARLACDLLPCNSDLRDLL 181
L H A +++++ + DL + D+R LL
Sbjct: 923 LAHG-ADPTMKNQEGQTPLDLATAD-DIRALL 952
Score = 68.6 bits (166), Expect = 3e-12
Identities = 43/122 (35%), Positives = 61/122 (50%), Gaps = 2/122 (1%)
Query: 61 DSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHG 120
D T LH A+ + Q LL+ GA A+ GG LH A GH E+ LLL HG
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425
Query: 121 SNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDL 180
+ +D T LH+AA + ++CSLLL H A + + + A D+ P +LR+
Sbjct: 426 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG-ADPTLVNCHGKSAVDMAP-TPELRER 483
Query: 181 LS 182
L+
Sbjct: 484 LT 485
Score = 65.5 bits (158), Expect = 2e-11
Identities = 37/105 (35%), Positives = 59/105 (56%), Gaps = 4/105 (3%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L++K + ++ + T LH A+ H V + L + GAK +A G TALHRA+ GH
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSP 154
+ RLLLS+GS+P ++ G T AA+ G+ + +L + +P
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTP 644
Score = 58.2 bits (139), Expect = 4e-09
Identities = 33/91 (36%), Positives = 47/91 (51%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+ L+Q D D G LH A GHY V + LL+ GA +A T LH A+
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444
Query: 107 CGHTEIARLLLSHGSNPRVVDDDGMTSLHKA 137
E+ LLLSHG++P +V+ G +++ A
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 57.4 bits (137), Expect = 7e-09
Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 3/118 (2%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGH---YAVCQFLLESGAKCDAQT 94
AA DL +VK + + + TALH A + H V + LL GA + +
Sbjct: 496 AAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH A+ H ++ +L HG+ +D G T+LH+AA GH C LLL +
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613
Score = 56.2 bits (134), Expect = 2e-08
Identities = 31/91 (34%), Positives = 47/91 (51%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+HL+Q + D G LH A GH V LL GA +A+ + T LH A+
Sbjct: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAI 291
Query: 107 CGHTEIARLLLSHGSNPRVVDDDGMTSLHKA 137
G ++ +LL HG++P + + DG ++L A
Sbjct: 292 KGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322
Score = 52.0 bits (123), Expect = 3e-07
Identities = 39/143 (27%), Positives = 60/143 (41%), Gaps = 21/143 (14%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYA--------------------SRNGHY 77
AA+ G + L+Q DP+ ++ G +AL A +R+G+
Sbjct: 289 AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 348
Query: 78 AVCQFLLES-GAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHK 136
LL C A +T LH A+ I +LLL HG++ D G+ LH
Sbjct: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
Query: 137 AAERGHGDICSLLLQHSPALKAI 159
A GH ++ LLL+H + A+
Sbjct: 409 ACSYGHYEVTELLLKHGACVNAM 431
Score = 44.7 bits (104), Expect = 5e-05
Identities = 38/150 (25%), Positives = 56/150 (37%), Gaps = 35/150 (23%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLES----------- 86
AAL G L + L+ DPS G+T A++ G+ AV Q L ES
Sbjct: 598 AALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYR 653
Query: 87 --------------------GAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
C +T LH A+ + LL HG++
Sbjct: 654 LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK 713
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPAL 156
D G+ LH A GH ++ LL++H ++
Sbjct: 714 DKGGLVPLHNACSYGHYEVAELLVRHGASV 743
Score = 43.9 bits (102), Expect = 8e-05
Identities = 26/70 (37%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
Query: 93 QTHGGATALHRASYCGHT---EIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
Q TALH A H ++ LLL G+N + D MT LH AAER H D+ +L
Sbjct: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
Query: 150 LQHSPALKAI 159
+H + A+
Sbjct: 578 HKHGAKMNAL 587
Score = 38.1 bits (87), Expect = 0.004
Identities = 38/166 (22%), Positives = 54/166 (32%), Gaps = 54/166 (32%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V++L+ D D G LH A GHY V + L+ GA + T LH A+
Sbjct: 700 VEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAA 759
Query: 107 CGHTEIARLLLSH----------GSNPRVVDDDG-------------------------- 130
G EI +LLL H G+ P + +G
Sbjct: 760 KGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARV 819
Query: 131 ------------------MTSLHKAAERGHGDICSLLLQHSPALKA 158
T LH AA + ++ LL+H + A
Sbjct: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 865
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 82.0 bits (201), Expect = 3e-16
Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 48 KHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
K L+ K P+ G+T LH A + H V + LL++GA DA T G T LH AS+
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARL 166
GH I + LL G++P V + T LH AA GH ++ LLQ+ + A +D + L
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
Query: 167 AC 168
C
Sbjct: 508 HC 509
Score = 78.6 bits (192), Expect = 3e-15
Identities = 43/114 (37%), Positives = 64/114 (56%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G L VK+L+Q+ P+ + T LH A+R GH V ++LL++ AK +A+
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
T LH A+ GHT + +LLL + +NP + G T LH AA GH + LL+
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 557
Score = 76.3 bits (186), Expect = 1e-14
Identities = 41/121 (33%), Positives = 64/121 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A + +L VK L+ + P P GYT LH A++ V + LL+ G +A++ G
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A+ GH E+ LLLS +N + + G+T LH A+ GH + +L++H +
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 158 A 158
A
Sbjct: 729 A 729
Score = 73.6 bits (179), Expect = 9e-14
Identities = 47/131 (35%), Positives = 63/131 (48%), Gaps = 5/131 (3%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D + + AA G VK L++ +P+ +AG+T LH A+R GH LLE A
Sbjct: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T G T LH A+ G +A LLL ++P +G+T LH A + DI LL
Sbjct: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Query: 150 L-----QHSPA 155
L HSPA
Sbjct: 622 LPRGGSPHSPA 632
Score = 73.6 bits (179), Expect = 9e-14
Identities = 40/115 (34%), Positives = 63/115 (54%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G V L+ K + + + +G T LH ++ GH V L++ G DA T G
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH AS+ G+ ++ + LL H ++ G + LH+AA++GH DI +LLL++
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
Score = 70.1 bits (170), Expect = 1e-12
Identities = 43/121 (35%), Positives = 56/121 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA N D L+Q +P G+T LH A+ + V Q LL GA + G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH AS G+ + RLLL G+ D +T LH AA GH I +LL H ++
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332
Query: 158 A 158
A
Sbjct: 333 A 333
Score = 67.0 bits (162), Expect = 9e-12
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 9/157 (5%)
Query: 34 GIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQ 93
G+ A+ G + V L+ K G TALH A+ G V + L+ GA +AQ
Sbjct: 81 GLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 140
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
+ G T L+ A+ H E+ + LL +G+N V +DG T L A ++GH ++ + L+ +
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 154 -------PALK-AIRDRKARLACDLLPCNSDLRDLLS 182
PAL A R+ R A LL N D+LS
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLS 236
Score = 67.0 bits (162), Expect = 9e-12
Identities = 35/96 (36%), Positives = 54/96 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH ASR G+ + + LL+ GA+ + +T T LH A+ GH I+ +LL HG+
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAI 159
+ +G++ +H AA+ H D LLLQ+ + I
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 367
Score = 65.9 bits (159), Expect = 2e-11
Identities = 35/86 (40%), Positives = 51/86 (59%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
GYT LH AS G+ + +FLL+ A +A+T G + LH+A+ GHT+I LLL +G++P
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLL 149
V DG T L A G+ + +L
Sbjct: 794 NEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 64.3 bits (155), Expect = 6e-11
Identities = 36/113 (31%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G++ V+ L+ + T LH A+RNGH + + LL+ GA A+T G
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ +H A+ H + RLLL + + + D +T LH AA GH + +LL
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Score = 63.2 bits (152), Expect = 1e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 2/142 (1%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSA-GYTALHYASRNGHYAV 79
G Q + D + AA NG + R+ ++ P Q + G + +H A++ H
Sbjct: 295 GAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353
Query: 80 CQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAE 139
+ LL+ A+ D T T LH A++CGH +A++LL G+ P +G T LH A +
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 413
Query: 140 RGHGDICSLLLQHSPALKAIRD 161
+ H + LLL+ ++ A+ +
Sbjct: 414 KNHVRVMELLLKTGASIDAVTE 435
Score = 62.8 bits (151), Expect = 2e-10
Identities = 35/115 (30%), Positives = 57/115 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA +G+L + ++ D + + G LH AS+ GH + LL + T G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
TALH A+ G E+ R L+++G+N G T L+ AA+ H ++ LL++
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Score = 62.4 bits (150), Expect = 2e-10
Identities = 39/121 (32%), Positives = 60/121 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L++K + G+T LH A++ G V + LLE A +A G
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A + + +I +LLL G +P +G T LH AA++ ++ LLQ+ +
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
Query: 158 A 158
A
Sbjct: 663 A 663
Score = 60.5 bits (145), Expect = 8e-10
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + + L+++ P+ G T LH A + + + + LL G + G
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ E+AR LL +G + G+T LH AA+ GH ++ +LLL
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Score = 58.9 bits (141), Expect = 2e-09
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G + + E + AA G K+L+Q + T LH A+R GH +
Sbjct: 460 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 519
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LLE+ A + T G T LH A+ GH E LL ++ + G T LH AA+
Sbjct: 520 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 579
Query: 141 GHGDICSLLLQ 151
G + LLL+
Sbjct: 580 GKVRVAELLLE 590
Score = 55.8 bits (133), Expect = 2e-08
Identities = 35/121 (28%), Positives = 51/121 (42%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA + + L+Q + G T LH A++ GH + LL A + G
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH + GH +A +L+ HG G T LH A+ G+ + LLQH +
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 158 A 158
A
Sbjct: 762 A 762
Score = 52.0 bits (123), Expect = 3e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 67 ALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
ALH A+RN LL++ D + G T LH A++ + +A+LLL+ G++
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+G+T LH A+ RG+ + LLL ++ +D L C
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 311
Score = 43.1 bits (100), Expect = 1e-04
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ VK L+Q D + GY+ LH A++ GH + LL++GA + + G T L
Sbjct: 745 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
Query: 102 HRASYCGHTEIARLL 116
A G+ + +L
Sbjct: 805 AIAKRLGYISVTDVL 819
Score = 27.3 bits (59), Expect = 7.5
Identities = 14/45 (31%), Positives = 25/45 (55%)
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGH 142
AT+ RA+ G+ + A L +G + + +G+ LH A++ GH
Sbjct: 46 ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGH 90
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 82.0 bits (201), Expect = 3e-16
Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 48 KHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
K L+ K P+ G+T LH A + H V + LL++GA DA T G T LH AS+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARL 166
GH I + LL G++P V + T LH AA GH ++ LLQ+ + A +D + L
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 167 AC 168
C
Sbjct: 475 HC 476
Score = 78.6 bits (192), Expect = 3e-15
Identities = 43/114 (37%), Positives = 64/114 (56%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G L VK+L+Q+ P+ + T LH A+R GH V ++LL++ AK +A+
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
T LH A+ GHT + +LLL + +NP + G T LH AA GH + LL+
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 76.3 bits (186), Expect = 1e-14
Identities = 41/121 (33%), Positives = 64/121 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A + +L VK L+ + P P GYT LH A++ V + LL+ G +A++ G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A+ GH E+ LLLS +N + + G+T LH A+ GH + +L++H +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 158 A 158
A
Sbjct: 696 A 696
Score = 73.6 bits (179), Expect = 9e-14
Identities = 47/131 (35%), Positives = 63/131 (48%), Gaps = 5/131 (3%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D + + AA G VK L++ +P+ +AG+T LH A+R GH LLE A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T G T LH A+ G +A LLL ++P +G+T LH A + DI LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 150 L-----QHSPA 155
L HSPA
Sbjct: 589 LPRGGSPHSPA 599
Score = 73.6 bits (179), Expect = 9e-14
Identities = 40/115 (34%), Positives = 63/115 (54%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G V L+ K + + + +G T LH ++ GH V L++ G DA T G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH AS+ G+ ++ + LL H ++ G + LH+AA++GH DI +LLL++
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Score = 70.1 bits (170), Expect = 1e-12
Identities = 43/121 (35%), Positives = 56/121 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA N D L+Q +P G+T LH A+ + V Q LL GA + G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH AS G+ + RLLL G+ D +T LH AA GH I +LL H ++
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 158 A 158
A
Sbjct: 300 A 300
Score = 67.0 bits (162), Expect = 9e-12
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 9/157 (5%)
Query: 34 GIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQ 93
G+ A+ G + V L+ K G TALH A+ G V + L+ GA +AQ
Sbjct: 48 GLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
+ G T L+ A+ H E+ + LL +G+N V +DG T L A ++GH ++ + L+ +
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 154 -------PALK-AIRDRKARLACDLLPCNSDLRDLLS 182
PAL A R+ R A LL N D+LS
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLS 203
Score = 67.0 bits (162), Expect = 9e-12
Identities = 35/96 (36%), Positives = 54/96 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH ASR G+ + + LL+ GA+ + +T T LH A+ GH I+ +LL HG+
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAI 159
+ +G++ +H AA+ H D LLLQ+ + I
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Score = 65.9 bits (159), Expect = 2e-11
Identities = 35/86 (40%), Positives = 51/86 (59%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
GYT LH AS G+ + +FLL+ A +A+T G + LH+A+ GHT+I LLL +G++P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLL 149
V DG T L A G+ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 6e-11
Identities = 36/113 (31%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G++ V+ L+ + T LH A+RNGH + + LL+ GA A+T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ +H A+ H + RLLL + + + D +T LH AA GH + +LL
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 7e-11
Identities = 37/125 (29%), Positives = 59/125 (47%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E D AA +G+L + ++ D + + G LH AS+ GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICS 147
+ T G TALH A+ G E+ R L+++G+N G T L+ AA+ H ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 148 LLLQH 152
LL++
Sbjct: 129 FLLEN 133
Score = 63.2 bits (152), Expect = 1e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 2/142 (1%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSA-GYTALHYASRNGHYAV 79
G Q + D + AA NG + R+ ++ P Q + G + +H A++ H
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 80 CQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAE 139
+ LL+ A+ D T T LH A++CGH +A++LL G+ P +G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 140 RGHGDICSLLLQHSPALKAIRD 161
+ H + LLL+ ++ A+ +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTE 402
Score = 62.4 bits (150), Expect = 2e-10
Identities = 39/121 (32%), Positives = 60/121 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L++K + G+T LH A++ G V + LLE A +A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A + + +I +LLL G +P +G T LH AA++ ++ LLQ+ +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 158 A 158
A
Sbjct: 630 A 630
Score = 60.5 bits (145), Expect = 8e-10
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + + L+++ P+ G T LH A + + + + LL G + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ E+AR LL +G + G+T LH AA+ GH ++ +LLL
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 58.9 bits (141), Expect = 2e-09
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G + + E + AA G K+L+Q + T LH A+R GH +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LLE+ A + T G T LH A+ GH E LL ++ + G T LH AA+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546
Query: 141 GHGDICSLLLQ 151
G + LLL+
Sbjct: 547 GKVRVAELLLE 557
Score = 55.8 bits (133), Expect = 2e-08
Identities = 35/121 (28%), Positives = 51/121 (42%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA + + L+Q + G T LH A++ GH + LL A + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH + GH +A +L+ HG G T LH A+ G+ + LLQH +
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 158 A 158
A
Sbjct: 729 A 729
Score = 52.0 bits (123), Expect = 3e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 67 ALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
ALH A+RN LL++ D + G T LH A++ + +A+LLL+ G++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+G+T LH A+ RG+ + LLL ++ +D L C
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Score = 43.1 bits (100), Expect = 1e-04
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ VK L+Q D + GY+ LH A++ GH + LL++GA + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Query: 102 HRASYCGHTEIARLL 116
A G+ + +L
Sbjct: 772 AIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 82.0 bits (201), Expect = 3e-16
Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 48 KHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
K L+ K P+ G+T LH A + H V + LL++GA DA T G T LH AS+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARL 166
GH I + LL G++P V + T LH AA GH ++ LLQ+ + A +D + L
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 167 AC 168
C
Sbjct: 475 HC 476
Score = 78.6 bits (192), Expect = 3e-15
Identities = 43/114 (37%), Positives = 64/114 (56%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G L VK+L+Q+ P+ + T LH A+R GH V ++LL++ AK +A+
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
T LH A+ GHT + +LLL + +NP + G T LH AA GH + LL+
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 76.3 bits (186), Expect = 1e-14
Identities = 41/121 (33%), Positives = 64/121 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A + +L VK L+ + P P GYT LH A++ V + LL+ G +A++ G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A+ GH E+ LLLS +N + + G+T LH A+ GH + +L++H +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 158 A 158
A
Sbjct: 696 A 696
Score = 73.6 bits (179), Expect = 9e-14
Identities = 47/131 (35%), Positives = 63/131 (48%), Gaps = 5/131 (3%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D + + AA G VK L++ +P+ +AG+T LH A+R GH LLE A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T G T LH A+ G +A LLL ++P +G+T LH A + DI LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 150 L-----QHSPA 155
L HSPA
Sbjct: 589 LPRGGSPHSPA 599
Score = 73.6 bits (179), Expect = 9e-14
Identities = 40/115 (34%), Positives = 63/115 (54%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G V L+ K + + + +G T LH ++ GH V L++ G DA T G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH AS+ G+ ++ + LL H ++ G + LH+AA++GH DI +LLL++
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Score = 70.1 bits (170), Expect = 1e-12
Identities = 43/121 (35%), Positives = 56/121 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA N D L+Q +P G+T LH A+ + V Q LL GA + G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH AS G+ + RLLL G+ D +T LH AA GH I +LL H ++
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 158 A 158
A
Sbjct: 300 A 300
Score = 67.0 bits (162), Expect = 9e-12
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 9/157 (5%)
Query: 34 GIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQ 93
G+ A+ G + V L+ K G TALH A+ G V + L+ GA +AQ
Sbjct: 48 GLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
+ G T L+ A+ H E+ + LL +G+N V +DG T L A ++GH ++ + L+ +
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 154 -------PALK-AIRDRKARLACDLLPCNSDLRDLLS 182
PAL A R+ R A LL N D+LS
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLS 203
Score = 67.0 bits (162), Expect = 9e-12
Identities = 35/96 (36%), Positives = 54/96 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH ASR G+ + + LL+ GA+ + +T T LH A+ GH I+ +LL HG+
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAI 159
+ +G++ +H AA+ H D LLLQ+ + I
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Score = 65.9 bits (159), Expect = 2e-11
Identities = 35/86 (40%), Positives = 51/86 (59%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
GYT LH AS G+ + +FLL+ A +A+T G + LH+A+ GHT+I LLL +G++P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLL 149
V DG T L A G+ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 6e-11
Identities = 36/113 (31%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G++ V+ L+ + T LH A+RNGH + + LL+ GA A+T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ +H A+ H + RLLL + + + D +T LH AA GH + +LL
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 7e-11
Identities = 37/125 (29%), Positives = 59/125 (47%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E D AA +G+L + ++ D + + G LH AS+ GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICS 147
+ T G TALH A+ G E+ R L+++G+N G T L+ AA+ H ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 148 LLLQH 152
LL++
Sbjct: 129 FLLEN 133
Score = 63.2 bits (152), Expect = 1e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 2/142 (1%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSA-GYTALHYASRNGHYAV 79
G Q + D + AA NG + R+ ++ P Q + G + +H A++ H
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 80 CQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAE 139
+ LL+ A+ D T T LH A++CGH +A++LL G+ P +G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 140 RGHGDICSLLLQHSPALKAIRD 161
+ H + LLL+ ++ A+ +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTE 402
Score = 62.4 bits (150), Expect = 2e-10
Identities = 39/121 (32%), Positives = 60/121 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L++K + G+T LH A++ G V + LLE A +A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A + + +I +LLL G +P +G T LH AA++ ++ LLQ+ +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 158 A 158
A
Sbjct: 630 A 630
Score = 60.5 bits (145), Expect = 8e-10
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + + L+++ P+ G T LH A + + + + LL G + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ E+AR LL +G + G+T LH AA+ GH ++ +LLL
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 58.9 bits (141), Expect = 2e-09
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G + + E + AA G K+L+Q + T LH A+R GH +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LLE+ A + T G T LH A+ GH E LL ++ + G T LH AA+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546
Query: 141 GHGDICSLLLQ 151
G + LLL+
Sbjct: 547 GKVRVAELLLE 557
Score = 55.8 bits (133), Expect = 2e-08
Identities = 35/121 (28%), Positives = 51/121 (42%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA + + L+Q + G T LH A++ GH + LL A + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH + GH +A +L+ HG G T LH A+ G+ + LLQH +
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 158 A 158
A
Sbjct: 729 A 729
Score = 52.0 bits (123), Expect = 3e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 67 ALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
ALH A+RN LL++ D + G T LH A++ + +A+LLL+ G++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+G+T LH A+ RG+ + LLL ++ +D L C
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Score = 43.1 bits (100), Expect = 1e-04
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ VK L+Q D + GY+ LH A++ GH + LL++GA + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Query: 102 HRASYCGHTEIARLL 116
A G+ + +L
Sbjct: 772 AIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 82.0 bits (201), Expect = 3e-16
Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 48 KHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
K L+ K P+ G+T LH A + H V + LL++GA DA T G T LH AS+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARL 166
GH I + LL G++P V + T LH AA GH ++ LLQ+ + A +D + L
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 167 AC 168
C
Sbjct: 475 HC 476
Score = 78.6 bits (192), Expect = 3e-15
Identities = 43/114 (37%), Positives = 64/114 (56%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G L VK+L+Q+ P+ + T LH A+R GH V ++LL++ AK +A+
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
T LH A+ GHT + +LLL + +NP + G T LH AA GH + LL+
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 76.3 bits (186), Expect = 1e-14
Identities = 41/121 (33%), Positives = 64/121 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A + +L VK L+ + P P GYT LH A++ V + LL+ G +A++ G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A+ GH E+ LLLS +N + + G+T LH A+ GH + +L++H +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 158 A 158
A
Sbjct: 696 A 696
Score = 73.6 bits (179), Expect = 9e-14
Identities = 47/131 (35%), Positives = 63/131 (48%), Gaps = 5/131 (3%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D + + AA G VK L++ +P+ +AG+T LH A+R GH LLE A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T G T LH A+ G +A LLL ++P +G+T LH A + DI LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 150 L-----QHSPA 155
L HSPA
Sbjct: 589 LPRGGSPHSPA 599
Score = 73.6 bits (179), Expect = 9e-14
Identities = 40/115 (34%), Positives = 63/115 (54%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G V L+ K + + + +G T LH ++ GH V L++ G DA T G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH AS+ G+ ++ + LL H ++ G + LH+AA++GH DI +LLL++
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Score = 70.1 bits (170), Expect = 1e-12
Identities = 43/121 (35%), Positives = 56/121 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA N D L+Q +P G+T LH A+ + V Q LL GA + G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH AS G+ + RLLL G+ D +T LH AA GH I +LL H ++
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 158 A 158
A
Sbjct: 300 A 300
Score = 67.0 bits (162), Expect = 9e-12
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 9/157 (5%)
Query: 34 GIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQ 93
G+ A+ G + V L+ K G TALH A+ G V + L+ GA +AQ
Sbjct: 48 GLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
+ G T L+ A+ H E+ + LL +G+N V +DG T L A ++GH ++ + L+ +
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 154 -------PALK-AIRDRKARLACDLLPCNSDLRDLLS 182
PAL A R+ R A LL N D+LS
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLS 203
Score = 67.0 bits (162), Expect = 9e-12
Identities = 35/96 (36%), Positives = 54/96 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH ASR G+ + + LL+ GA+ + +T T LH A+ GH I+ +LL HG+
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAI 159
+ +G++ +H AA+ H D LLLQ+ + I
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Score = 65.9 bits (159), Expect = 2e-11
Identities = 35/86 (40%), Positives = 51/86 (59%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
GYT LH AS G+ + +FLL+ A +A+T G + LH+A+ GHT+I LLL +G++P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLL 149
V DG T L A G+ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 6e-11
Identities = 36/113 (31%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G++ V+ L+ + T LH A+RNGH + + LL+ GA A+T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ +H A+ H + RLLL + + + D +T LH AA GH + +LL
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 7e-11
Identities = 37/125 (29%), Positives = 59/125 (47%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E D AA +G+L + ++ D + + G LH AS+ GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICS 147
+ T G TALH A+ G E+ R L+++G+N G T L+ AA+ H ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 148 LLLQH 152
LL++
Sbjct: 129 FLLEN 133
Score = 63.2 bits (152), Expect = 1e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 2/142 (1%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSA-GYTALHYASRNGHYAV 79
G Q + D + AA NG + R+ ++ P Q + G + +H A++ H
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 80 CQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAE 139
+ LL+ A+ D T T LH A++CGH +A++LL G+ P +G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 140 RGHGDICSLLLQHSPALKAIRD 161
+ H + LLL+ ++ A+ +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTE 402
Score = 62.4 bits (150), Expect = 2e-10
Identities = 39/121 (32%), Positives = 60/121 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L++K + G+T LH A++ G V + LLE A +A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A + + +I +LLL G +P +G T LH AA++ ++ LLQ+ +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 158 A 158
A
Sbjct: 630 A 630
Score = 60.5 bits (145), Expect = 8e-10
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + + L+++ P+ G T LH A + + + + LL G + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ E+AR LL +G + G+T LH AA+ GH ++ +LLL
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 58.9 bits (141), Expect = 2e-09
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G + + E + AA G K+L+Q + T LH A+R GH +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LLE+ A + T G T LH A+ GH E LL ++ + G T LH AA+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546
Query: 141 GHGDICSLLLQ 151
G + LLL+
Sbjct: 547 GKVRVAELLLE 557
Score = 55.8 bits (133), Expect = 2e-08
Identities = 35/121 (28%), Positives = 51/121 (42%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA + + L+Q + G T LH A++ GH + LL A + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH + GH +A +L+ HG G T LH A+ G+ + LLQH +
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 158 A 158
A
Sbjct: 729 A 729
Score = 52.0 bits (123), Expect = 3e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 67 ALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
ALH A+RN LL++ D + G T LH A++ + +A+LLL+ G++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+G+T LH A+ RG+ + LLL ++ +D L C
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Score = 43.1 bits (100), Expect = 1e-04
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ VK L+Q D + GY+ LH A++ GH + LL++GA + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Query: 102 HRASYCGHTEIARLL 116
A G+ + +L
Sbjct: 772 AIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 82.0 bits (201), Expect = 3e-16
Identities = 46/122 (37%), Positives = 64/122 (52%), Gaps = 1/122 (0%)
Query: 48 KHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
K L+ K P+ G+T LH A + H V + LL++GA DA T G T LH AS+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARL 166
GH I + LL G++P V + T LH AA GH ++ LLQ+ + A +D + L
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Query: 167 AC 168
C
Sbjct: 475 HC 476
Score = 78.6 bits (192), Expect = 3e-15
Identities = 43/114 (37%), Positives = 64/114 (56%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G L VK+L+Q+ P+ + T LH A+R GH V ++LL++ AK +A+
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
T LH A+ GHT + +LLL + +NP + G T LH AA GH + LL+
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE 524
Score = 76.3 bits (186), Expect = 1e-14
Identities = 41/121 (33%), Positives = 64/121 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A + +L VK L+ + P P GYT LH A++ V + LL+ G +A++ G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A+ GH E+ LLLS +N + + G+T LH A+ GH + +L++H +
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 158 A 158
A
Sbjct: 696 A 696
Score = 73.6 bits (179), Expect = 9e-14
Identities = 47/131 (35%), Positives = 63/131 (48%), Gaps = 5/131 (3%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D + + AA G VK L++ +P+ +AG+T LH A+R GH LLE A
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T G T LH A+ G +A LLL ++P +G+T LH A + DI LL
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 150 L-----QHSPA 155
L HSPA
Sbjct: 589 LPRGGSPHSPA 599
Score = 73.6 bits (179), Expect = 9e-14
Identities = 40/115 (34%), Positives = 63/115 (54%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G V L+ K + + + +G T LH ++ GH V L++ G DA T G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH AS+ G+ ++ + LL H ++ G + LH+AA++GH DI +LLL++
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Score = 70.1 bits (170), Expect = 1e-12
Identities = 43/121 (35%), Positives = 56/121 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA N D L+Q +P G+T LH A+ + V Q LL GA + G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH AS G+ + RLLL G+ D +T LH AA GH I +LL H ++
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299
Query: 158 A 158
A
Sbjct: 300 A 300
Score = 67.0 bits (162), Expect = 9e-12
Identities = 51/157 (32%), Positives = 76/157 (48%), Gaps = 9/157 (5%)
Query: 34 GIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQ 93
G+ A+ G + V L+ K G TALH A+ G V + L+ GA +AQ
Sbjct: 48 GLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ 107
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
+ G T L+ A+ H E+ + LL +G+N V +DG T L A ++GH ++ + L+ +
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 154 -------PALK-AIRDRKARLACDLLPCNSDLRDLLS 182
PAL A R+ R A LL N D+LS
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQ-NDPNPDVLS 203
Score = 67.0 bits (162), Expect = 9e-12
Identities = 35/96 (36%), Positives = 54/96 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH ASR G+ + + LL+ GA+ + +T T LH A+ GH I+ +LL HG+
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAI 159
+ +G++ +H AA+ H D LLLQ+ + I
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Score = 65.9 bits (159), Expect = 2e-11
Identities = 35/86 (40%), Positives = 51/86 (59%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
GYT LH AS G+ + +FLL+ A +A+T G + LH+A+ GHT+I LLL +G++P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLL 149
V DG T L A G+ + +L
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 64.3 bits (155), Expect = 6e-11
Identities = 36/113 (31%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G++ V+ L+ + T LH A+RNGH + + LL+ GA A+T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ +H A+ H + RLLL + + + D +T LH AA GH + +LL
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 63.9 bits (154), Expect = 7e-11
Identities = 37/125 (29%), Positives = 59/125 (47%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E D AA +G+L + ++ D + + G LH AS+ GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICS 147
+ T G TALH A+ G E+ R L+++G+N G T L+ AA+ H ++
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128
Query: 148 LLLQH 152
LL++
Sbjct: 129 FLLEN 133
Score = 63.2 bits (152), Expect = 1e-10
Identities = 41/142 (28%), Positives = 70/142 (49%), Gaps = 2/142 (1%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSA-GYTALHYASRNGHYAV 79
G Q + D + AA NG + R+ ++ P Q + G + +H A++ H
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 80 CQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAE 139
+ LL+ A+ D T T LH A++CGH +A++LL G+ P +G T LH A +
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 140 RGHGDICSLLLQHSPALKAIRD 161
+ H + LLL+ ++ A+ +
Sbjct: 381 KNHVRVMELLLKTGASIDAVTE 402
Score = 62.4 bits (150), Expect = 2e-10
Identities = 39/121 (32%), Positives = 60/121 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L++K + G+T LH A++ G V + LLE A +A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH A + + +I +LLL G +P +G T LH AA++ ++ LLQ+ +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 158 A 158
A
Sbjct: 630 A 630
Score = 60.5 bits (145), Expect = 8e-10
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + + L+++ P+ G T LH A + + + + LL G + G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ E+AR LL +G + G+T LH AA+ GH ++ +LLL
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 58.9 bits (141), Expect = 2e-09
Identities = 40/131 (30%), Positives = 58/131 (44%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G + + E + AA G K+L+Q + T LH A+R GH +
Sbjct: 427 GASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LLE+ A + T G T LH A+ GH E LL ++ + G T LH AA+
Sbjct: 487 KLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546
Query: 141 GHGDICSLLLQ 151
G + LLL+
Sbjct: 547 GKVRVAELLLE 557
Score = 55.8 bits (133), Expect = 2e-08
Identities = 35/121 (28%), Positives = 51/121 (42%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA + + L+Q + G T LH A++ GH + LL A + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T LH + GH +A +L+ HG G T LH A+ G+ + LLQH +
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 158 A 158
A
Sbjct: 729 A 729
Score = 52.0 bits (123), Expect = 3e-07
Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 1/103 (0%)
Query: 67 ALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
ALH A+RN LL++ D + G T LH A++ + +A+LLL+ G++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+G+T LH A+ RG+ + LLL ++ +D L C
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHC 278
Score = 43.1 bits (100), Expect = 1e-04
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ VK L+Q D + GY+ LH A++ GH + LL++GA + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Query: 102 HRASYCGHTEIARLL 116
A G+ + +L
Sbjct: 772 AIAKRLGYISVTDVL 786
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 80.1 bits (196), Expect = 1e-15
Identities = 44/131 (33%), Positives = 63/131 (48%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G + ++ + + A G + ++HL++ P D +GY LH A+ G Y +C
Sbjct: 517 GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC 576
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL GA + TH G T LH A+Y GH EI LL +N + T LH AA
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARH 636
Query: 141 GHGDICSLLLQ 151
G + S LLQ
Sbjct: 637 GEEAVVSALLQ 647
Score = 70.1 bits (170), Expect = 1e-12
Identities = 39/109 (35%), Positives = 57/109 (52%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L+ D ++ D G+ LH+A++NG + LL+ GA DAQ G T LH A+
Sbjct: 414 LLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF 473
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
+ARLL+S ++P + + +G T LH AA GH + LL L A
Sbjct: 474 ENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA 522
Score = 68.9 bits (167), Expect = 2e-12
Identities = 44/130 (33%), Positives = 64/130 (49%), Gaps = 4/130 (3%)
Query: 32 ERGIWS----AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
ER W+ AA N + L+ + DP+ ++ G T LH A+ GH ++ + L G
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICS 147
A+ DAQ T LH A G + LL G+ P +D G LH AA RG IC
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICK 577
Query: 148 LLLQHSPALK 157
+LL++ +L+
Sbjct: 578 MLLRYGASLE 587
Score = 58.5 bits (140), Expect = 3e-09
Identities = 48/163 (29%), Positives = 69/163 (42%), Gaps = 12/163 (7%)
Query: 26 LEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLE 85
L E + + + AA G + VK L + + T LH A G Q LL+
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 86 SGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDI 145
SGA DA G LH A+ G I ++LL +G++ + G T LH AA +GH +I
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
Query: 146 CSLLLQH------------SPALKAIRDRKARLACDLLPCNSD 176
LL + +P A R + + LL C +D
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD 651
Score = 54.3 bits (129), Expect = 6e-08
Identities = 32/93 (34%), Positives = 43/93 (46%)
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV 125
T LH+ G + LL D QT G T L A+ ++ LLL+HG++
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 126 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
VD+DG LH AA+ G LLL H + A
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA 456
Score = 53.9 bits (128), Expect = 7e-08
Identities = 34/109 (31%), Positives = 53/109 (48%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G + +V+ L+ D ++GYT L A+++ +C LL GA + G L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 102 HRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
H A+ G ARLLL HG+ + +G T LH AA+ ++ LL+
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Score = 53.1 bits (126), Expect = 1e-07
Identities = 36/116 (31%), Positives = 49/116 (42%)
Query: 37 SAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
+AA G K L++ P G+T LH A+ GH + L ES A A
Sbjct: 566 TAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAV 625
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH A+ G + LL G++P + G T LH A +R LL+H
Sbjct: 626 NWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH 681
Score = 50.4 bits (119), Expect = 8e-07
Identities = 37/126 (29%), Positives = 56/126 (44%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA +G+ V L+Q DP+ + +G+T LH A + + LLE A A+ G
Sbjct: 633 AARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG 692
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
T H A+ G+T I ++L+ G+ V D T L A I S L P++
Sbjct: 693 WTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVA 752
Query: 158 AIRDRK 163
+ K
Sbjct: 753 TLGGSK 758
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 80.1 bits (196), Expect = 1e-15
Identities = 51/124 (41%), Positives = 65/124 (52%), Gaps = 4/124 (3%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L V L+Q P + G TALH A+R G V + LL +GA DA+
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ----HS 153
T LH AS G TEI +LLL H ++P +G T LH +A G D+ S+LL+ HS
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Query: 154 PALK 157
A K
Sbjct: 537 LATK 540
Score = 77.0 bits (188), Expect = 8e-15
Identities = 42/127 (33%), Positives = 66/127 (51%)
Query: 26 LEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLE 85
L++ D AA G+L +V ++ D + + G ALH A++ GH + Q LL
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 86 SGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDI 145
G+ D+ T G TALH AS G E+ ++L+ G+N +G T L+ AA+ H D+
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 146 CSLLLQH 152
LL++
Sbjct: 125 VKYLLEN 131
Score = 73.6 bits (179), Expect = 9e-14
Identities = 45/137 (32%), Positives = 70/137 (51%), Gaps = 4/137 (2%)
Query: 29 MDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGA 88
+D+ + AA G K L+ K +P+ G+T LH A + V + L++ GA
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 401
Query: 89 KCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSL 148
A T G T +H A++ GH I LLL +G++P V + G T+LH AA G ++
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 149 LLQHSPALKAIRDRKAR 165
LL++ A+ D +AR
Sbjct: 462 LLRNG----ALVDARAR 474
Score = 72.8 bits (177), Expect = 2e-13
Identities = 38/115 (33%), Positives = 61/115 (53%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G +G V+ L+ + G TALH AS G V + L++ GA +AQ+ G
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L+ A+ H ++ + LL +G+N +DG T L A ++GH ++LL++
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164
Score = 71.6 bits (174), Expect = 3e-13
Identities = 37/103 (35%), Positives = 54/103 (52%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L++K P GYT LH A++ + LL GA+ + T G T LH AS GH
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T++ LLL G+N + G+TSLH AA+ ++ +L +H
Sbjct: 654 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 68.2 bits (165), Expect = 4e-12
Identities = 41/113 (36%), Positives = 56/113 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L K L+Q+ G T LH A+ + V LLE GA A G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ +IA LL++G+ +V G+T LH A++ GH D+ +LLL
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Score = 67.8 bits (164), Expect = 5e-12
Identities = 38/96 (39%), Positives = 48/96 (50%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G+T LH A+ G+ V LL GA D G T LH AS G+T + +LLL G
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
DG+T LH AA GH + LLL+ L A
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306
Score = 67.0 bits (162), Expect = 9e-12
Identities = 42/113 (37%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G+ VK L+ + G T LH A+R+GH V + LLE GA A+T G
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ LH A+ H E + LL H + V D +T+LH AA GH + LLL
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 364
Score = 66.6 bits (161), Expect = 1e-11
Identities = 39/115 (33%), Positives = 58/115 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G V L+ K + +G T+LH A++ V L + GA DA T G
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L A + G+ ++ LL G+N +G T LH+AA++GH I ++LLQH
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Score = 65.9 bits (159), Expect = 2e-11
Identities = 34/89 (38%), Positives = 50/89 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH AS+ G+ + + LL+ G + DA+T G T LH A+ GH ++ LLL G+
Sbjct: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+G++ LH AA+ H + LLQH
Sbjct: 305 LARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Score = 62.8 bits (151), Expect = 2e-10
Identities = 35/100 (35%), Positives = 49/100 (49%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L + D GYT L A G+ + FLL+ GA +A+T G T LH+A+ GH
Sbjct: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T I +LL HG+ P +G T+L A G+ + L
Sbjct: 753 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 62.0 bits (149), Expect = 3e-10
Identities = 37/105 (35%), Positives = 53/105 (50%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+ L+Q P + GYT LH ++R G V LLE+GA T G T LH A+
Sbjct: 492 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 551
Query: 107 CGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
G ++A+LLL + +G+T LH AA + + LLL+
Sbjct: 552 YGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 596
Score = 61.6 bits (148), Expect = 4e-10
Identities = 36/115 (31%), Positives = 57/115 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
+A G + L++ S G+T LH A++ G V + LL+ A D+ G
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH A++ + ++A LLL G++P +G T LH AA++ I S LL +
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630
Score = 60.1 bits (144), Expect = 1e-09
Identities = 34/90 (37%), Positives = 47/90 (52%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G T +H A+ GH + LL++GA D G TALH A+ G E+ R LL +G+
Sbjct: 409 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 468
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+ T LH A+ G +I LLLQH
Sbjct: 469 VDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Score = 60.1 bits (144), Expect = 1e-09
Identities = 42/124 (33%), Positives = 58/124 (46%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + AA G + V+ L++ T LH ASR G + Q LL+ A D
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
A T G T LH ++ G ++A +LL G+ + G T LH AA+ G D+ LLLQ
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Query: 152 HSPA 155
A
Sbjct: 564 RRAA 567
Score = 53.1 bits (126), Expect = 1e-07
Identities = 35/115 (30%), Positives = 58/115 (50%), Gaps = 4/115 (3%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+L G VK L+++ + + G+T L+ A++ H V ++LLE+GA T G
Sbjct: 83 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L A GH + +LL + + +V + +LH AA + +LLLQ+
Sbjct: 143 FTPLAVALQQGHNQAVAILLENDTKGKV----RLPALHIAARKDDTKSAALLLQN 193
Score = 52.4 bits (124), Expect = 2e-07
Identities = 45/172 (26%), Positives = 69/172 (40%), Gaps = 38/172 (22%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK----- 89
++ AA + VK+L++ + S G+T L A + GH LLE+ K
Sbjct: 113 LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 172
Query: 90 ------------------------CDAQ--------THGGATALHRASYCGHTEIARLLL 117
D Q T G T LH A++ G+ +A LLL
Sbjct: 173 PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 232
Query: 118 SHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+ G+ +G+T LH A++RG+ ++ LLL + A RD L C
Sbjct: 233 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 284
Score = 45.8 bits (107), Expect = 2e-05
Identities = 25/75 (33%), Positives = 39/75 (52%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ V L+++ + + GYT LH A++ GH + LL+ GAK +A T G TAL
Sbjct: 718 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Query: 102 HRASYCGHTEIARLL 116
A G+ + L
Sbjct: 778 AIAKRLGYISVVDTL 792
Score = 38.9 bits (89), Expect = 0.002
Identities = 24/88 (27%), Positives = 40/88 (45%)
Query: 71 ASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDG 130
A+R G+ L+ G + G ALH A+ GH + + LL GS+ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 131 MTSLHKAAERGHGDICSLLLQHSPALKA 158
T+LH A+ G ++ +L++ + A
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINA 104
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 80.1 bits (196), Expect = 1e-15
Identities = 51/124 (41%), Positives = 65/124 (52%), Gaps = 4/124 (3%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L V L+Q P + G TALH A+R G V + LL +GA DA+
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ----HS 153
T LH AS G TEI +LLL H ++P +G T LH +A G D+ S+LL+ HS
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 154 PALK 157
A K
Sbjct: 558 LATK 561
Score = 75.1 bits (183), Expect = 3e-14
Identities = 41/126 (32%), Positives = 65/126 (51%)
Query: 27 EEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLES 86
++ D AA G+L +V ++ D + + G ALH A++ GH + Q LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 87 GAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDIC 146
G+ D+ T G TALH AS G E+ ++L+ G+N +G T L+ AA+ H D+
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 147 SLLLQH 152
LL++
Sbjct: 147 KYLLEN 152
Score = 73.6 bits (179), Expect = 9e-14
Identities = 45/137 (32%), Positives = 70/137 (51%), Gaps = 4/137 (2%)
Query: 29 MDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGA 88
+D+ + AA G K L+ K +P+ G+T LH A + V + L++ GA
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 89 KCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSL 148
A T G T +H A++ GH I LLL +G++P V + G T+LH AA G ++
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 149 LLQHSPALKAIRDRKAR 165
LL++ A+ D +AR
Sbjct: 483 LLRNG----ALVDARAR 495
Score = 72.8 bits (177), Expect = 2e-13
Identities = 38/115 (33%), Positives = 61/115 (53%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G +G V+ L+ + G TALH AS G V + L++ GA +AQ+ G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L+ A+ H ++ + LL +G+N +DG T L A ++GH ++LL++
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 71.6 bits (174), Expect = 3e-13
Identities = 37/103 (35%), Positives = 54/103 (52%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L++K P GYT LH A++ + LL GA+ + T G T LH AS GH
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T++ LLL G+N + G+TSLH AA+ ++ +L +H
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 68.2 bits (165), Expect = 4e-12
Identities = 41/113 (36%), Positives = 56/113 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L K L+Q+ G T LH A+ + V LLE GA A G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ +IA LL++G+ +V G+T LH A++ GH D+ +LLL
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Score = 67.8 bits (164), Expect = 5e-12
Identities = 38/96 (39%), Positives = 48/96 (50%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G+T LH A+ G+ V LL GA D G T LH AS G+T + +LLL G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
DG+T LH AA GH + LLL+ L A
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Score = 67.0 bits (162), Expect = 9e-12
Identities = 42/113 (37%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G+ VK L+ + G T LH A+R+GH V + LLE GA A+T G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ LH A+ H E + LL H + V D +T+LH AA GH + LLL
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385
Score = 66.6 bits (161), Expect = 1e-11
Identities = 39/115 (33%), Positives = 58/115 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G V L+ K + +G T+LH A++ V L + GA DA T G
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L A + G+ ++ LL G+N +G T LH+AA++GH I ++LLQH
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 65.9 bits (159), Expect = 2e-11
Identities = 34/89 (38%), Positives = 50/89 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH AS+ G+ + + LL+ G + DA+T G T LH A+ GH ++ LLL G+
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+G++ LH AA+ H + LLQH
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 62.8 bits (151), Expect = 2e-10
Identities = 35/100 (35%), Positives = 49/100 (49%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L + D GYT L A G+ + FLL+ GA +A+T G T LH+A+ GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T I +LL HG+ P +G T+L A G+ + L
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 62.0 bits (149), Expect = 3e-10
Identities = 37/105 (35%), Positives = 53/105 (50%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+ L+Q P + GYT LH ++R G V LLE+GA T G T LH A+
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 572
Query: 107 CGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
G ++A+LLL + +G+T LH AA + + LLL+
Sbjct: 573 YGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 61.6 bits (148), Expect = 4e-10
Identities = 36/115 (31%), Positives = 57/115 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
+A G + L++ S G+T LH A++ G V + LL+ A D+ G
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH A++ + ++A LLL G++P +G T LH AA++ I S LL +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651
Score = 60.1 bits (144), Expect = 1e-09
Identities = 34/90 (37%), Positives = 47/90 (52%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G T +H A+ GH + LL++GA D G TALH A+ G E+ R LL +G+
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+ T LH A+ G +I LLLQH
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 60.1 bits (144), Expect = 1e-09
Identities = 42/124 (33%), Positives = 58/124 (46%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + AA G + V+ L++ T LH ASR G + Q LL+ A D
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
A T G T LH ++ G ++A +LL G+ + G T LH AA+ G D+ LLLQ
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Query: 152 HSPA 155
A
Sbjct: 585 RRAA 588
Score = 53.1 bits (126), Expect = 1e-07
Identities = 35/115 (30%), Positives = 58/115 (50%), Gaps = 4/115 (3%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+L G VK L+++ + + G+T L+ A++ H V ++LLE+GA T G
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L A GH + +LL + + +V + +LH AA + +LLLQ+
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKV----RLPALHIAARKDDTKSAALLLQN 214
Score = 52.4 bits (124), Expect = 2e-07
Identities = 45/172 (26%), Positives = 69/172 (40%), Gaps = 38/172 (22%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK----- 89
++ AA + VK+L++ + S G+T L A + GH LLE+ K
Sbjct: 134 LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 193
Query: 90 ------------------------CDAQ--------THGGATALHRASYCGHTEIARLLL 117
D Q T G T LH A++ G+ +A LLL
Sbjct: 194 PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 253
Query: 118 SHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+ G+ +G+T LH A++RG+ ++ LLL + A RD L C
Sbjct: 254 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
Score = 45.8 bits (107), Expect = 2e-05
Identities = 25/75 (33%), Positives = 39/75 (52%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ V L+++ + + GYT LH A++ GH + LL+ GAK +A T G TAL
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Query: 102 HRASYCGHTEIARLL 116
A G+ + L
Sbjct: 799 AIAKRLGYISVVDTL 813
Score = 40.0 bits (92), Expect = 0.001
Identities = 28/107 (26%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 52 QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTE 111
Q+ + P + DS + A+R G+ L+ G + G ALH A+ GH
Sbjct: 21 QRRKRPKKSDSNA--SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVG 78
Query: 112 IARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
+ + LL GS+ G T+LH A+ G ++ +L++ + A
Sbjct: 79 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 80.1 bits (196), Expect = 1e-15
Identities = 51/124 (41%), Positives = 65/124 (52%), Gaps = 4/124 (3%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L V L+Q P + G TALH A+R G V + LL +GA DA+
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ----HS 153
T LH AS G TEI +LLL H ++P +G T LH +A G D+ S+LL+ HS
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 154 PALK 157
A K
Sbjct: 558 LATK 561
Score = 75.1 bits (183), Expect = 3e-14
Identities = 41/126 (32%), Positives = 65/126 (51%)
Query: 27 EEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLES 86
++ D AA G+L +V ++ D + + G ALH A++ GH + Q LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 87 GAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDIC 146
G+ D+ T G TALH AS G E+ ++L+ G+N +G T L+ AA+ H D+
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 147 SLLLQH 152
LL++
Sbjct: 147 KYLLEN 152
Score = 73.6 bits (179), Expect = 9e-14
Identities = 45/137 (32%), Positives = 70/137 (51%), Gaps = 4/137 (2%)
Query: 29 MDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGA 88
+D+ + AA G K L+ K +P+ G+T LH A + V + L++ GA
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Query: 89 KCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSL 148
A T G T +H A++ GH I LLL +G++P V + G T+LH AA G ++
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 149 LLQHSPALKAIRDRKAR 165
LL++ A+ D +AR
Sbjct: 483 LLRNG----ALVDARAR 495
Score = 72.8 bits (177), Expect = 2e-13
Identities = 38/115 (33%), Positives = 61/115 (53%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G +G V+ L+ + G TALH AS G V + L++ GA +AQ+ G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L+ A+ H ++ + LL +G+N +DG T L A ++GH ++LL++
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 71.6 bits (174), Expect = 3e-13
Identities = 37/103 (35%), Positives = 54/103 (52%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L++K P GYT LH A++ + LL GA+ + T G T LH AS GH
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T++ LLL G+N + G+TSLH AA+ ++ +L +H
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 68.2 bits (165), Expect = 4e-12
Identities = 41/113 (36%), Positives = 56/113 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L K L+Q+ G T LH A+ + V LLE GA A G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ +IA LL++G+ +V G+T LH A++ GH D+ +LLL
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Score = 67.8 bits (164), Expect = 5e-12
Identities = 38/96 (39%), Positives = 48/96 (50%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G+T LH A+ G+ V LL GA D G T LH AS G+T + +LLL G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
DG+T LH AA GH + LLL+ L A
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Score = 67.0 bits (162), Expect = 9e-12
Identities = 42/113 (37%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G+ VK L+ + G T LH A+R+GH V + LLE GA A+T G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
+ LH A+ H E + LL H + V D +T+LH AA GH + LLL
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385
Score = 66.6 bits (161), Expect = 1e-11
Identities = 39/115 (33%), Positives = 58/115 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G V L+ K + +G T+LH A++ V L + GA DA T G
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L A + G+ ++ LL G+N +G T LH+AA++GH I ++LLQH
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 65.9 bits (159), Expect = 2e-11
Identities = 34/89 (38%), Positives = 50/89 (56%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G T LH AS+ G+ + + LL+ G + DA+T G T LH A+ GH ++ LLL G+
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+G++ LH AA+ H + LLQH
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Score = 62.8 bits (151), Expect = 2e-10
Identities = 35/100 (35%), Positives = 49/100 (49%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L + D GYT L A G+ + FLL+ GA +A+T G T LH+A+ GH
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
T I +LL HG+ P +G T+L A G+ + L
Sbjct: 774 THIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 62.0 bits (149), Expect = 3e-10
Identities = 37/105 (35%), Positives = 53/105 (50%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+ L+Q P + GYT LH ++R G V LLE+GA T G T LH A+
Sbjct: 513 VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAK 572
Query: 107 CGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
G ++A+LLL + +G+T LH AA + + LLL+
Sbjct: 573 YGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE 617
Score = 61.6 bits (148), Expect = 4e-10
Identities = 36/115 (31%), Positives = 57/115 (49%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
+A G + L++ S G+T LH A++ G V + LL+ A D+ G
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T LH A++ + ++A LLL G++P +G T LH AA++ I S LL +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651
Score = 60.1 bits (144), Expect = 1e-09
Identities = 34/90 (37%), Positives = 47/90 (52%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G T +H A+ GH + LL++GA D G TALH A+ G E+ R LL +G+
Sbjct: 430 SGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL 489
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
+ T LH A+ G +I LLLQH
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Score = 60.1 bits (144), Expect = 1e-09
Identities = 42/124 (33%), Positives = 58/124 (46%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + AA G + V+ L++ T LH ASR G + Q LL+ A D
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
A T G T LH ++ G ++A +LL G+ + G T LH AA+ G D+ LLLQ
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Query: 152 HSPA 155
A
Sbjct: 585 RRAA 588
Score = 53.1 bits (126), Expect = 1e-07
Identities = 35/115 (30%), Positives = 58/115 (50%), Gaps = 4/115 (3%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+L G VK L+++ + + G+T L+ A++ H V ++LLE+GA T G
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L A GH + +LL + + +V + +LH AA + +LLLQ+
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKV----RLPALHIAARKDDTKSAALLLQN 214
Score = 52.4 bits (124), Expect = 2e-07
Identities = 45/172 (26%), Positives = 69/172 (40%), Gaps = 38/172 (22%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK----- 89
++ AA + VK+L++ + S G+T L A + GH LLE+ K
Sbjct: 134 LYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 193
Query: 90 ------------------------CDAQ--------THGGATALHRASYCGHTEIARLLL 117
D Q T G T LH A++ G+ +A LLL
Sbjct: 194 PALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 253
Query: 118 SHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+ G+ +G+T LH A++RG+ ++ LLL + A RD L C
Sbjct: 254 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHC 305
Score = 45.8 bits (107), Expect = 2e-05
Identities = 25/75 (33%), Positives = 39/75 (52%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ V L+++ + + GYT LH A++ GH + LL+ GAK +A T G TAL
Sbjct: 739 GNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Query: 102 HRASYCGHTEIARLL 116
A G+ + L
Sbjct: 799 AIAKRLGYISVVDTL 813
Score = 40.0 bits (92), Expect = 0.001
Identities = 28/107 (26%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 52 QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTE 111
Q+ + P + DS + A+R G+ L+ G + G ALH A+ GH
Sbjct: 21 QRRKRPKKSDSNA--SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVG 78
Query: 112 IARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
+ + LL GS+ G T+LH A+ G ++ +L++ + A
Sbjct: 79 LVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 79.3 bits (194), Expect = 2e-15
Identities = 40/119 (33%), Positives = 63/119 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L+ P+ + G TALH A+R+G V ++L++ GA+ +A+
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPAL 156
T LH ++ G +I + LL G++P G T LH +A GH D+ + LL H +L
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Score = 77.4 bits (189), Expect = 6e-15
Identities = 45/130 (34%), Positives = 65/130 (50%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + D + + +A G V+ L+Q+ P+ ++GYT LH ++R GH V
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
FLL+ GA T G T LH A+ G E+A LLL ++P G+T LH AA
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 141 GHGDICSLLL 150
+ + LLL
Sbjct: 609 DNQKVALLLL 618
Score = 75.1 bits (183), Expect = 3e-14
Identities = 41/129 (31%), Positives = 63/129 (48%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D+ + AA G K L+ K +P+ G+T LH A + V + LL+ GA
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
A T G T +H A++ GH I L+ HG++P + G T+LH AA G ++ L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 150 LQHSPALKA 158
+Q ++A
Sbjct: 486 VQDGAQVEA 494
Score = 73.2 bits (178), Expect = 1e-13
Identities = 48/152 (31%), Positives = 75/152 (49%), Gaps = 7/152 (4%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G + V L+Q+ + G TALH AS G V + L+ +GA +AQ+ G
Sbjct: 81 ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS---- 153
T L+ A+ H E+ + LL +G++ + +DG T L A ++GH + SLLL++
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGK 200
Query: 154 ---PALKAIRDRKARLACDLLPCNSDLRDLLS 182
PAL + A LL N + D+ S
Sbjct: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVES 232
Score = 72.8 bits (177), Expect = 2e-13
Identities = 41/115 (35%), Positives = 60/115 (52%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L + I+ D + + G ALH AS+ GH V LL+ A DA T G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
TALH AS G E+ ++L+++G+N +G T L+ AA+ H ++ LL +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN 162
Score = 72.0 bits (175), Expect = 3e-13
Identities = 42/122 (34%), Positives = 63/122 (51%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + AA +G V++L+Q T LH ++R G + Q LL+ GA +
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
A T G T LH ++ GH ++A LL HG++ + G T LH AA+ G ++ +LLLQ
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ 586
Query: 152 HS 153
S
Sbjct: 587 KS 588
Score = 70.9 bits (172), Expect = 6e-13
Identities = 39/116 (33%), Positives = 62/116 (53%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G + V L+ + + + + +G T LH A++ V + L+ GA DAQT G
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
T LH + G+ +I LL H + +G T LH+AA++GH I ++LLQ++
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Score = 70.1 bits (170), Expect = 1e-12
Identities = 42/113 (37%), Positives = 57/113 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L L+QK+ P +G T LH A+ + V LL+ GA A G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
T LH A+ +IA LL +G++ V G+ S+H AA+ GH D+ SLLL
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Score = 68.9 bits (167), Expect = 2e-12
Identities = 36/115 (31%), Positives = 61/115 (53%)
Query: 47 VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASY 106
V+ L+ +A G + LH A++ H Q LL+ D T+ TALH A++
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAH 376
Query: 107 CGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRD 161
CGH ++A++LL +NP +G T LH A ++ + LLL+H +++A+ +
Sbjct: 377 CGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431
Score = 65.1 bits (157), Expect = 3e-11
Identities = 34/96 (35%), Positives = 52/96 (54%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
G+T LH A++ G V LL+ A DA G T LH A++ + ++A LLL G++P
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAI 159
+G T LH AA++ DI + LL++ A+
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
Score = 63.2 bits (152), Expect = 1e-10
Identities = 37/116 (31%), Positives = 58/116 (50%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G++ L+ +A T LH AS+ G+ + + LL+ GAK DA+T G
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
T LH + GH ++ +LL + +G++ LH A + H + LLLQH+
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHN 357
Score = 63.2 bits (152), Expect = 1e-10
Identities = 40/124 (32%), Positives = 61/124 (49%), Gaps = 2/124 (1%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A+ G+ VK L+ + G T LH +R+GH V + LL+ A ++T G
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL--QHSPA 155
+ LH A+ H +LLL H V +D +T+LH AA GH + +LL + +P
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Query: 156 LKAI 159
KA+
Sbjct: 395 AKAL 398
Score = 61.6 bits (148), Expect = 4e-10
Identities = 32/109 (29%), Positives = 53/109 (48%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L+ + P GYT LH A++ + LLE GA +A T G ++H A+ GH
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
++ LLL +N + + G+T LH AA+ ++ +L+ + A
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA 725
Score = 60.1 bits (144), Expect = 1e-09
Identities = 36/116 (31%), Positives = 50/116 (43%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA D L+Q + +G+T LH A+ G+ V LL A D
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
T LH AS G+ + +LLL G+ DG+T LH A GH + +LL +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Score = 59.7 bits (143), Expect = 1e-09
Identities = 31/86 (36%), Positives = 47/86 (54%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNP 123
GYT LH G+ + FLL+ AK +A+T G T LH+A+ GHT I +LL + ++P
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 124 RVVDDDGMTSLHKAAERGHGDICSLL 149
+ +G T+L A G+ + L
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTL 815
Score = 55.5 bits (132), Expect = 3e-08
Identities = 32/96 (33%), Positives = 44/96 (45%)
Query: 63 AGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN 122
+G T +H A+ GH + L+ GA + G TALH A+ G E+ R L+ G+
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 123 PRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
D T LH +A G DI LLQ + A
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Score = 55.1 bits (131), Expect = 3e-08
Identities = 40/122 (32%), Positives = 57/122 (46%), Gaps = 4/122 (3%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
++ AA L VK L+ S G+T L A + GH V LLE+ K +
Sbjct: 144 LYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR- 202
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSP 154
ALH A+ T+ A LLL + +N V G T LH AA G+ ++ +LLL +
Sbjct: 203 ---LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA 259
Query: 155 AL 156
A+
Sbjct: 260 AV 261
Score = 52.4 bits (124), Expect = 2e-07
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 1/103 (0%)
Query: 67 ALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
ALH A+R LL++ D ++ G T LH A++ G+ +A LLL+ +
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 127 DDDGMTSLHKAAERGHGDICSLLLQHSPALKA-IRDRKARLAC 168
+ +T LH A++RG+ ++ LLL + A RD L C
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHC 307
Score = 43.5 bits (101), Expect = 1e-04
Identities = 28/107 (26%), Positives = 48/107 (44%), Gaps = 1/107 (0%)
Query: 52 QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTE 111
+++ D + A + L A+R GH +++G + G ALH AS GH E
Sbjct: 30 KRSRDRKKKSDANASYLR-AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 112 IARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
+ LL +N G T+LH A+ G ++ +L+ + + A
Sbjct: 89 VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
Score = 40.4 bits (93), Expect = 9e-04
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 42 GDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G++ V L+Q + + GYT LH A++ GH + LL++ A + T G TAL
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Query: 102 HRASYCGHTEIARLLLSHGSNPRVVDDDGMTS 133
A G+ + L ++V ++ MT+
Sbjct: 801 GIARRLGYISVVDTL-------KIVTEETMTT 825
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 79.0 bits (193), Expect = 2e-15
Identities = 48/115 (41%), Positives = 65/115 (56%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G+L VK LI+ + + D +TAL AS+ GH + + LL+ G + + GG
Sbjct: 45 AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
TAL A Y G T++ LLLSHG+NP V + + AA RGH DI LLLQ+
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
Score = 60.8 bits (146), Expect = 6e-10
Identities = 49/154 (31%), Positives = 66/154 (42%), Gaps = 13/154 (8%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
+W AA G L VKHL+ D Q + TAL A + G+ + +L+ +
Sbjct: 175 VW-AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTD 233
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSP 154
G TAL AS GHTEI + LL G+ + D G T L A GH +I LLQ
Sbjct: 234 KDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYA 293
Query: 155 ALK------------AIRDRKARLACDLLPCNSD 176
+ A+ A + D+L CN D
Sbjct: 294 DIDIRGQDNKTALYWAVEKGNATMVRDILQCNPD 327
Score = 58.9 bits (141), Expect = 2e-09
Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 1/143 (0%)
Query: 12 CCSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYA 71
C H A +G E + + A G VK ++++ + + D G TAL A
Sbjct: 185 CVKHLLA-MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIA 243
Query: 72 SRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGM 131
S+ GH + Q LL++G + G T L A GH EI R LL ++ + D
Sbjct: 244 SKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303
Query: 132 TSLHKAAERGHGDICSLLLQHSP 154
T+L+ A E+G+ + +LQ +P
Sbjct: 304 TALYWAVEKGNATMVRDILQCNP 326
Score = 57.0 bits (136), Expect = 9e-09
Identities = 39/116 (33%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
IW+A G V L+Q + D G T L +A+R GH + LL GA D +
Sbjct: 142 IWAAG-RGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
TAL A G+T+ + +L N + D DG T+L A++ GH +I LL
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Score = 52.8 bits (125), Expect = 2e-07
Identities = 39/130 (30%), Positives = 58/130 (44%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G LE++D + SA+ G + V+ L++ + D G+TAL +A G V
Sbjct: 61 GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV 120
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL GA + A+ GH +I LLL +G+ D G T L AA +
Sbjct: 121 ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
Query: 141 GHGDICSLLL 150
GH + LL
Sbjct: 181 GHLECVKHLL 190
Score = 50.1 bits (118), Expect = 1e-06
Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 1/138 (0%)
Query: 26 LEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLE 85
L + D + A+ G V+ L+ + PD +G T L A R GH + + LL+
Sbjct: 231 LTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQ 290
Query: 86 SGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDI 145
A D + TAL+ A G+ + R +L + + DG T L KA + + ++
Sbjct: 291 KYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEV 350
Query: 146 CSLLLQHSPALKAIRDRK 163
LLL + A+ D+K
Sbjct: 351 VELLLDKGAKVSAV-DKK 367
Score = 47.0 bits (110), Expect = 9e-06
Identities = 33/115 (28%), Positives = 52/115 (45%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A G + V+ L+QK D TAL++A G+ + + +L+ + T G
Sbjct: 276 AVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDG 335
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
T L +A+ + E+ LLL G+ VD G T LH A + LLL++
Sbjct: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 390
Score = 44.7 bits (104), Expect = 5e-05
Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 4/127 (3%)
Query: 32 ERGIWSAAL----NGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
+ G W+A + G V+ L+ +PS + +A+ GH + LL++G
Sbjct: 101 DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG 160
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICS 147
AK + G T L A+ GH E + LL+ G++ + MT+L A + G+
Sbjct: 161 AKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVK 220
Query: 148 LLLQHSP 154
+L+ +P
Sbjct: 221 EILKRNP 227
Score = 35.8 bits (81), Expect = 0.021
Identities = 27/97 (27%), Positives = 45/97 (46%)
Query: 30 DFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAK 89
D + ++ A G+ V+ ++Q D G T L A++ + V + LL+ GAK
Sbjct: 301 DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK 360
Query: 90 CDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
A G T LH A ++A LLL + + R++
Sbjct: 361 VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLL 397
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 75.9 bits (185), Expect = 2e-14
Identities = 42/114 (36%), Positives = 59/114 (51%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A G G V L+++ + D AG T LH A GH + + LL+ GA A G
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
TALH A++ GH+ +A LLL G++ G+T LH AA GH + + LL+
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE 161
Score = 75.9 bits (185), Expect = 2e-14
Identities = 51/129 (39%), Positives = 63/129 (48%), Gaps = 5/129 (3%)
Query: 34 GIWSAALNGDLGR---VKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKC 90
G + L LGR ++ L+ DP D G +ALH A+ GH Q L+ GA+
Sbjct: 236 GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEV 295
Query: 91 DAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
DA+ G T LH AS GH E+A LL G+ T LH AAERGHG LLL
Sbjct: 296 DARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLL 355
Query: 151 QH--SPALK 157
SP L+
Sbjct: 356 SRGASPTLR 364
Score = 65.5 bits (158), Expect = 2e-11
Identities = 44/136 (32%), Positives = 64/136 (47%), Gaps = 29/136 (21%)
Query: 36 WSAALNGDLGRVKHLIQKAEDPSQP---DSAGYTALHYASRNGHYAVCQ----------- 81
W+AAL L + L P+ D+ G+TA H+A+ G AV +
Sbjct: 146 WAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG 205
Query: 82 ---------------FLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVV 126
FLL GA+ DA+ GATAL A+ G ++ +LL HG++P +
Sbjct: 206 ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIR 265
Query: 127 DDDGMTSLHKAAERGH 142
D G ++LH+AA RGH
Sbjct: 266 DRHGRSALHRAAARGH 281
Score = 61.2 bits (147), Expect = 5e-10
Identities = 39/106 (36%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
Query: 53 KAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEI 112
+ E PS G+ L A G + LL GA + + H G T LH A GH +
Sbjct: 32 RTEGPSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPL 89
Query: 113 ARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKA 158
RLLL G+ VD G T+LH+AA GH + LLLQ + A
Sbjct: 90 VRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
Score = 59.3 bits (142), Expect = 2e-09
Identities = 39/108 (36%), Positives = 54/108 (50%), Gaps = 5/108 (4%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G L V+ L+ + + D+ G T LH+ASR GH V LL+ GA+ DA
Sbjct: 276 AAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLR 335
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDI 145
T LH A+ GH LLLS G++P + T + A+ GD+
Sbjct: 336 KTPLHLAAERGHGPTVGLLLSRGASPTL-----RTQWAEVAQMPEGDL 378
Score = 57.8 bits (138), Expect = 5e-09
Identities = 38/121 (31%), Positives = 56/121 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA G ++ L+ + D AG TAL A+ G + LL GA + G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALK 157
+ALHRA+ GH +LL++ G+ D G+T LH A+ GH ++ LL +
Sbjct: 270 RSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVD 329
Query: 158 A 158
A
Sbjct: 330 A 330
Score = 41.2 bits (95), Expect = 5e-04
Identities = 44/160 (27%), Positives = 61/160 (38%), Gaps = 31/160 (19%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLES----GAKCDAQ 93
AA +G + L+Q+ + G T LH+A+ GH + LLE+ A +A+
Sbjct: 114 AAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAE 173
Query: 94 THGGATALHRASYCGHTEI--------------------------ARLLLSHGSNPRVVD 127
G TA H A+ G + R LL+ G+ D
Sbjct: 174 DARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARD 233
Query: 128 DDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARLA 167
G T+L AA G +LL H A IRDR R A
Sbjct: 234 GAGATALGLAAALGRSQDIEVLLGHG-ADPGIRDRHGRSA 272
Score = 35.4 bits (80), Expect = 0.028
Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 101 LHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIR 160
L +A + G + LL G++ D G T LH A RGH + LLLQ + A+
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAV- 103
Query: 161 DRKARLA 167
DR R A
Sbjct: 104 DRAGRTA 110
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 75.9 bits (185), Expect = 2e-14
Identities = 43/118 (36%), Positives = 64/118 (54%), Gaps = 1/118 (0%)
Query: 39 ALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGA 98
A+NG + L+Q D D+ G TALH A +NGH Q LL+SGA + GA
Sbjct: 139 AVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGA 198
Query: 99 TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPAL 156
T L+ A G + A++LL G+ + D +G+T L + G+G+ C +L+Q+ P L
Sbjct: 199 TPLYFACSHGQRDTAQILLLRGAK-YLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRL 255
Score = 63.5 bits (153), Expect = 9e-11
Identities = 37/101 (36%), Positives = 52/101 (51%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L++K +P+ D +G T LH A+RNG LLE A + + G TA+H + G
Sbjct: 84 LLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGR 143
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
TE+ L+ H S+ V D G T+LH A + GH LL
Sbjct: 144 TELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLL 184
Score = 52.0 bits (123), Expect = 3e-07
Identities = 39/116 (33%), Positives = 55/116 (47%), Gaps = 8/116 (6%)
Query: 44 LGRVKHLIQKA---EDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGA-- 98
L R+ +++A E P ++A YT + + H +V + L S +K D G
Sbjct: 8 LNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELL--SNSKFDVNYAFGRVK 65
Query: 99 -TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHS 153
+ LH A+ CG E LLL G+NP D G T LH AA G S LL++S
Sbjct: 66 RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYS 121
Score = 52.0 bits (123), Expect = 3e-07
Identities = 33/113 (29%), Positives = 54/113 (47%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA NG + L++ + D + ++ G TA+H+ + NG + L++ + D + G
Sbjct: 105 AARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMG 164
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
TALH A GH + LL G++ + G T L+ A G D +LL
Sbjct: 165 QTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL 217
Score = 45.8 bits (107), Expect = 2e-05
Identities = 25/85 (29%), Positives = 43/85 (50%)
Query: 68 LHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVD 127
LH A+ G LL+ GA + Q G T LH A+ G + LL + ++ + +
Sbjct: 69 LHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICN 128
Query: 128 DDGMTSLHKAAERGHGDICSLLLQH 152
++G+T++H A G ++ L+QH
Sbjct: 129 NEGLTAIHWLAVNGRTELLHDLVQH 153
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 75.5 bits (184), Expect = 2e-14
Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + A G L V+ L++ D +TAL A +GH V + LL+SGA+ +
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
+ L A+ GH E+A LL+ G+N V+D+G T L +AA GH ++ +LLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 152 HSPALKAIRDRKARLACDLLPCN--SDLRDLL 181
+ A + A L C S++ D L
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFL 524
Score = 65.9 bits (159), Expect = 2e-11
Identities = 51/177 (28%), Positives = 70/177 (39%), Gaps = 31/177 (17%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + FE + AA G + LI++ + + + GYT L A+R GH +
Sbjct: 428 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487
Query: 81 QFLLESGAKCDAQTH-------------------------------GGATALHRASYCGH 109
LL GA +AQT G +T L AS GH
Sbjct: 488 ALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGH 547
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARL 166
E+ + LL+ G+N G T+L A E GH D+ +LLQ L D K L
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 604
Score = 60.5 bits (145), Expect = 8e-10
Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
+ +A+ G L VK L+ D + + G TAL YA G + + LL GA +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTS-LHKAAERGHGDICSLLLQ 151
G T L A+ GH E+AR+LL HG+ ++ S L A +GH D+ LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Score = 52.0 bits (123), Expect = 3e-07
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV 125
T L AS G+ + + LL A ++Q+ G TAL A G +I ++LL+ G+N
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 126 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKA----IRDRKARLAC 168
+++G T L +AA GH ++ +LL H + ++ LAC
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 380
Score = 49.3 bits (116), Expect = 2e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 1/119 (0%)
Query: 33 RGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKC-D 91
R + A +GD+ V+ L+ + ++ G + L A G+Y + Q LL A D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G T L AS G+ +I +LLL H ++ G T+L A G DI +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Score = 45.4 bits (106), Expect = 3e-05
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + + + A ++G + + L+ + P + + L A+ GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV-VDDDGMTSLHKAAE 139
L+E GA + G T L A+ GH E+ LLL+ G+N ++ T+L A
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514
Query: 140 RGHGDICSLLLQ 151
G ++ L++
Sbjct: 515 GGFSEVADFLIK 526
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 75.5 bits (184), Expect = 2e-14
Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + A G L V+ L++ D +TAL A +GH V + LL+SGA+ +
Sbjct: 362 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 421
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
+ L A+ GH E+A LL+ G+N V+D+G T L +AA GH ++ +LLL
Sbjct: 422 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 481
Query: 152 HSPALKAIRDRKARLACDLLPCN--SDLRDLL 181
+ A + A L C S++ D L
Sbjct: 482 QGANINAQTEETQETALTLACCGGFSEVADFL 513
Score = 65.9 bits (159), Expect = 2e-11
Identities = 51/177 (28%), Positives = 70/177 (39%), Gaps = 31/177 (17%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + FE + AA G + LI++ + + + GYT L A+R GH +
Sbjct: 417 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 476
Query: 81 QFLLESGAKCDAQTH-------------------------------GGATALHRASYCGH 109
LL GA +AQT G +T L AS GH
Sbjct: 477 ALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGH 536
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPALKAIRDRKARL 166
E+ + LL+ G+N G T+L A E GH D+ +LLQ L D K L
Sbjct: 537 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTIL 593
Score = 60.5 bits (145), Expect = 8e-10
Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
+ +A+ G L VK L+ D + + G TAL YA G + + LL GA +
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTS-LHKAAERGHGDICSLLLQ 151
G T L A+ GH E+AR+LL HG+ ++ S L A +GH D+ LL+
Sbjct: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
Score = 52.0 bits (123), Expect = 3e-07
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV 125
T L AS G+ + + LL A ++Q+ G TAL A G +I ++LL+ G+N
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 126 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKA----IRDRKARLAC 168
+++G T L +AA GH ++ +LL H + ++ LAC
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
Score = 49.3 bits (116), Expect = 2e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 1/119 (0%)
Query: 33 RGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKC-D 91
R + A +GD+ V+ L+ + ++ G + L A G+Y + Q LL A D
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 255
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G T L AS G+ +I +LLL H ++ G T+L A G DI +LL
Sbjct: 256 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
Score = 45.4 bits (106), Expect = 3e-05
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + + + A ++G + + L+ + P + + L A+ GH +
Sbjct: 384 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 443
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV-VDDDGMTSLHKAAE 139
L+E GA + G T L A+ GH E+ LLL+ G+N ++ T+L A
Sbjct: 444 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 503
Query: 140 RGHGDICSLLLQ 151
G ++ L++
Sbjct: 504 GGFSEVADFLIK 515
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 75.5 bits (184), Expect = 2e-14
Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + A G L V+ L++ D +TAL A +GH V + LL+SGA+ +
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
+ L A+ GH E+A LL+ G+N V+D+G T L +AA GH ++ +LLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 152 HSPALKAIRDRKARLACDLLPCN--SDLRDLL 181
+ A + A L C S++ D L
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFL 524
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/126 (32%), Positives = 62/126 (49%), Gaps = 1/126 (0%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E+ + A+ G L VK+L+ + + G TAL YA NGH V LL++G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN-PRVVDDDGMTSLHKAAERGHGDIC 146
A + ++ GG T L +A+ GH + L+S G+N R ++ T + A GH +
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 147 SLLLQH 152
LLL H
Sbjct: 652 ELLLAH 657
Score = 60.5 bits (145), Expect = 8e-10
Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
+ +A+ G L VK L+ D + + G TAL YA G + + LL GA +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTS-LHKAAERGHGDICSLLLQ 151
G T L A+ GH E+AR+LL HG+ ++ S L A +GH D+ LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Score = 59.7 bits (143), Expect = 1e-09
Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 43 DLGRVKHLIQKAEDPSQPD--SAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATA 100
++GRV L+ K D + P S+ TAL A+ GHY C+ L+ GA D + G T
Sbjct: 1271 EVGRV--LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 101 LHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
L AS GH ++ +LL+ G++ D+ +T L A +GH + L++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 56.6 bits (135), Expect = 1e-08
Identities = 37/102 (36%), Positives = 51/102 (50%), Gaps = 3/102 (2%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L Q A +Q + TAL A G V FL+++GA + G +T L AS GH
Sbjct: 491 LAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGH 547
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
E+ + LL+ G+N G T+L A E GH D+ +LLQ
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 52.0 bits (123), Expect = 3e-07
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV 125
T L AS G+ + + LL A ++Q+ G TAL A G +I ++LL+ G+N
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 126 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKA----IRDRKARLAC 168
+++G T L +AA GH ++ +LL H + ++ LAC
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 380
Score = 50.1 bits (118), Expect = 1e-06
Identities = 43/140 (30%), Positives = 67/140 (47%), Gaps = 8/140 (5%)
Query: 38 AALNGDLGRVKHLIQK-AEDPSQPDSA-GYTALHYASRNGHYAVCQFLLESGAKCDAQTH 95
AA G + +K L+ AE S+ S G + L A+ NGH + LL+ G+ +AQ
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
Query: 96 GGA-TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ--- 151
TAL A + G E+ LLL +N G+T L +AA G+ ++ +LL
Sbjct: 1222 TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281
Query: 152 --HSPALKAIRDRKARLACD 169
++P + + RD +A D
Sbjct: 1282 DVNAPPVPSSRDTALTIAAD 1301
Score = 49.3 bits (116), Expect = 2e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 1/119 (0%)
Query: 33 RGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKC-D 91
R + A +GD+ V+ L+ + ++ G + L A G+Y + Q LL A D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G T L AS G+ +I +LLL H ++ G T+L A G DI +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Score = 47.4 bits (111), Expect = 7e-06
Identities = 37/124 (29%), Positives = 54/124 (43%), Gaps = 1/124 (0%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E + + + A G V LI + D G+T L A+ GH V + LL+ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 88 AKCDAQTHGGA-TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDIC 146
+AQ+ T L A G E+ LLL+ G+N + T L AA G+ +I
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 147 SLLL 150
+LL
Sbjct: 1172 KILL 1175
Score = 47.0 bits (110), Expect = 9e-06
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A G V L+ + + G T L A+ G+ V + LL+ GA +A
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 98 A--TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPA 155
+ TAL A+ GH + LL+ G++ V + G T L A+ GH D+ LL+Q
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Query: 156 LKAIRDRK 163
+ A +RK
Sbjct: 1351 VDAADNRK 1358
Score = 45.4 bits (106), Expect = 3e-05
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + + + A ++G + + L+ + P + + L A+ GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV-VDDDGMTSLHKAAE 139
L+E GA + G T L A+ GH E+ LLL+ G+N ++ T+L A
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514
Query: 140 RGHGDICSLLLQ 151
G ++ L++
Sbjct: 515 GGFSEVADFLIK 526
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 3/104 (2%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG--GATALHRASYC 107
L+ + + + + YT L A+ G+ + + LL +GA+ +++T G + L A+
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
Query: 108 GHTEIARLLLSHGSNPRV-VDDDGMTSLHKAAERGHGDICSLLL 150
GH +LLL GS+ ++ + T+L A +G ++ SLLL
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLL 1244
Score = 41.6 bits (96), Expect = 4e-04
Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 1/89 (1%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAG-YTALHYASRNGHYAVCQFLLESGAKCDAQ 93
+ AA G L V+ LI K + ++ + +T + A GH AV + LL GA +
Sbjct: 605 LMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHR 664
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSN 122
G+T L A+ GHT + LL + +N
Sbjct: 665 LKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
Score = 33.1 bits (74), Expect = 0.14
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 5/83 (6%)
Query: 91 DAQTHGGA-TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
DA T TAL A GH E+ +L++ + D G T L AA GH + +L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 150 LQHSPALKA----IRDRKARLAC 168
L ++A +D LAC
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLAC 1130
Score = 32.0 bits (71), Expect = 0.30
Identities = 17/51 (33%), Positives = 25/51 (49%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLE 85
+W A+ G V+ L+Q D D+ T L A R GH V Q+L++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 75.5 bits (184), Expect = 2e-14
Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 2/152 (1%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + A G L V+ L++ D +TAL A +GH V + LL+SGA+ +
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
+ L A+ GH E+A LL+ G+N V+D+G T L +AA GH ++ +LLL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 152 HSPALKAIRDRKARLACDLLPCN--SDLRDLL 181
+ A + A L C S++ D L
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADFL 524
Score = 65.5 bits (158), Expect = 2e-11
Identities = 41/126 (32%), Positives = 62/126 (49%), Gaps = 1/126 (0%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E+ + A+ G L VK+L+ + + G TAL YA NGH V LL++G
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 88 AKCDAQTHGGATALHRASYCGHTEIARLLLSHGSN-PRVVDDDGMTSLHKAAERGHGDIC 146
A + ++ GG T L +A+ GH + L+S G+N R ++ T + A GH +
Sbjct: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
Query: 147 SLLLQH 152
LLL H
Sbjct: 652 ELLLAH 657
Score = 60.5 bits (145), Expect = 8e-10
Identities = 39/118 (33%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQT 94
+ +A+ G L VK L+ D + + G TAL YA G + + LL GA +
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 95 HGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTS-LHKAAERGHGDICSLLLQ 151
G T L A+ GH E+AR+LL HG+ ++ S L A +GH D+ LL+
Sbjct: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Score = 59.7 bits (143), Expect = 1e-09
Identities = 37/111 (33%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 43 DLGRVKHLIQKAEDPSQPD--SAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATA 100
++GRV L+ K D + P S+ TAL A+ GHY C+ L+ GA D + G T
Sbjct: 1271 EVGRV--LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 101 LHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
L AS GH ++ +LL+ G++ D+ +T L A +GH + L++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 56.6 bits (135), Expect = 1e-08
Identities = 37/102 (36%), Positives = 51/102 (50%), Gaps = 3/102 (2%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGH 109
L Q A +Q + TAL A G V FL+++GA + G +T L AS GH
Sbjct: 491 LAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGH 547
Query: 110 TEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ 151
E+ + LL+ G+N G T+L A E GH D+ +LLQ
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Score = 52.0 bits (123), Expect = 3e-07
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV 125
T L AS G+ + + LL A ++Q+ G TAL A G +I ++LL+ G+N
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 126 VDDDGMTSLHKAAERGHGDICSLLLQHSPALKA----IRDRKARLAC 168
+++G T L +AA GH ++ +LL H + ++ LAC
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 380
Score = 50.1 bits (118), Expect = 1e-06
Identities = 43/140 (30%), Positives = 67/140 (47%), Gaps = 8/140 (5%)
Query: 38 AALNGDLGRVKHLIQK-AEDPSQPDSA-GYTALHYASRNGHYAVCQFLLESGAKCDAQTH 95
AA G + +K L+ AE S+ S G + L A+ NGH + LL+ G+ +AQ
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
Query: 96 GGA-TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQ--- 151
TAL A + G E+ LLL +N G+T L +AA G+ ++ +LL
Sbjct: 1222 TNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281
Query: 152 --HSPALKAIRDRKARLACD 169
++P + + RD +A D
Sbjct: 1282 DVNAPPVPSSRDTALTIAAD 1301
Score = 49.3 bits (116), Expect = 2e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 1/119 (0%)
Query: 33 RGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKC-D 91
R + A +GD+ V+ L+ + ++ G + L A G+Y + Q LL A D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G T L AS G+ +I +LLL H ++ G T+L A G DI +LL
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Score = 47.4 bits (111), Expect = 7e-06
Identities = 37/124 (29%), Positives = 54/124 (43%), Gaps = 1/124 (0%)
Query: 28 EMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESG 87
E + + + A G V LI + D G+T L A+ GH V + LL+ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 88 AKCDAQTHGGA-TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDIC 146
+AQ+ T L A G E+ LLL+ G+N + T L AA G+ +I
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 147 SLLL 150
+LL
Sbjct: 1172 KILL 1175
Score = 47.0 bits (110), Expect = 9e-06
Identities = 38/128 (29%), Positives = 58/128 (45%), Gaps = 2/128 (1%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
A G V L+ + + G T L A+ G+ V + LL+ GA +A
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 98 A--TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPA 155
+ TAL A+ GH + LL+ G++ V + G T L A+ GH D+ LL+Q
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
Query: 156 LKAIRDRK 163
+ A +RK
Sbjct: 1351 VDAADNRK 1358
Score = 45.4 bits (106), Expect = 3e-05
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 1/132 (0%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G Q + + + A ++G + + L+ + P + + L A+ GH +
Sbjct: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA 454
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV-VDDDGMTSLHKAAE 139
L+E GA + G T L A+ GH E+ LLL+ G+N ++ T+L A
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514
Query: 140 RGHGDICSLLLQ 151
G ++ L++
Sbjct: 515 GGFSEVADFLIK 526
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 3/104 (2%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG--GATALHRASYC 107
L+ + + + + YT L A+ G+ + + LL +GA+ +++T G + L A+
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
Query: 108 GHTEIARLLLSHGSNPRV-VDDDGMTSLHKAAERGHGDICSLLL 150
GH +LLL GS+ ++ + T+L A +G ++ SLLL
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLL 1244
Score = 41.6 bits (96), Expect = 4e-04
Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 1/89 (1%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAG-YTALHYASRNGHYAVCQFLLESGAKCDAQ 93
+ AA G L V+ LI K + ++ + +T + A GH AV + LL GA +
Sbjct: 605 LMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHR 664
Query: 94 THGGATALHRASYCGHTEIARLLLSHGSN 122
G+T L A+ GHT + LL + +N
Sbjct: 665 LKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
Score = 33.1 bits (74), Expect = 0.14
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 5/83 (6%)
Query: 91 DAQTHGGA-TALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
DA T TAL A GH E+ +L++ + D G T L AA GH + +L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 150 LQHSPALKA----IRDRKARLAC 168
L ++A +D LAC
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLAC 1130
Score = 32.0 bits (71), Expect = 0.30
Identities = 17/51 (33%), Positives = 25/51 (49%)
Query: 35 IWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLE 85
+W A+ G V+ L+Q D D+ T L A R GH V Q+L++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 74.7 bits (182), Expect = 4e-14
Identities = 52/166 (31%), Positives = 84/166 (50%), Gaps = 3/166 (1%)
Query: 16 PSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNG 75
P++ LGV T + D + AAL+G + L++ + ++ LH A + G
Sbjct: 731 PASGLGVNVTSQ--DGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQG 788
Query: 76 HYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLH 135
H+ V + LL+S AK + + G T L A GH E+ LLL HG++ ++ G T+LH
Sbjct: 789 HFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALH 848
Query: 136 KAAERGHGDICSLLLQHSPALKAIRDRKARLACDLLPCNSDLRDLL 181
+A H + LLL H +++ + R+ R A D NS + +LL
Sbjct: 849 EAVIEKHVFVVELLLLHGASVQVLNKRQ-RTAVDCAEQNSKIMELL 893
Score = 60.1 bits (144), Expect = 1e-09
Identities = 33/96 (34%), Positives = 49/96 (51%)
Query: 57 PSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLL 116
P D G+T LH A+ G ++ L+ GA +A + GAT LH A G+ + LL
Sbjct: 456 PFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLL 515
Query: 117 LSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
L + ++ V D++G T LH A GH D L+ +
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYY 551
Score = 52.4 bits (124), Expect = 2e-07
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA+ G + L+ K + D G T LH A + G+ +V LL A + Q + G
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVD---DDGMTSLHKAAERGHGDICSLLLQH 152
T LH A GH + + L+ + +D + G T LH AA G+ + LLQ+
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN 587
Score = 28.1 bits (61), Expect = 4.4
Identities = 15/38 (39%), Positives = 21/38 (55%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATAL 101
G T LH A+R G+ V + LL++GA + Q T L
Sbjct: 565 GDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPL 602
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 73.6 bits (179), Expect = 9e-14
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G T + + + AA G + ++ +I D + D+ G++ALH A++N H+
Sbjct: 46 GASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI 105
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL+S ++ G TALH A+ G + ++L H S + D DG L A +
Sbjct: 106 RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 165
Query: 141 GHGDICSLLLQHSPALKAIRDRKAR----LACDLLPCNS 175
GH +IC LL H + + R++ R LAC++ N+
Sbjct: 166 GHSEICHFLLDHGADVNS-RNKSGRTALMLACEIGSSNA 203
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/116 (34%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 AALNGDLGRVKHLI-QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
A NGD +V L+ +K ++ DS G TA H A+ GH + ++ G AQ
Sbjct: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 88
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
G +ALH A+ H E R LL VD G T+LH AA +G +L +H
Sbjct: 89 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 144
Score = 57.8 bits (138), Expect = 5e-09
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 33/163 (20%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS-------- 72
GV T ++ + AA N ++ L+Q DS+G TALHYA+
Sbjct: 79 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 138
Query: 73 -------------------------RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
+NGH +C FLL+ GA +++ G TAL A
Sbjct: 139 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 198
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G + L+ G++ +VD G +LH + + I SLLL
Sbjct: 199 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
Score = 33.9 bits (76), Expect = 0.080
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 13 CSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS 72
C H S + L+++D + A NG L+ D + + +G TAL A
Sbjct: 142 CEHKSPI-----NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 196
Query: 73 RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
G + L++ GA + G ALH + + I LLLS
Sbjct: 197 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 242
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 73.6 bits (179), Expect = 9e-14
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G T + + + AA G + ++ +I D + D+ G++ALH A++N H+
Sbjct: 35 GASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI 94
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL+S ++ G TALH A+ G + ++L H S + D DG L A +
Sbjct: 95 RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 154
Query: 141 GHGDICSLLLQHSPALKAIRDRKAR----LACDLLPCNS 175
GH +IC LL H + + R++ R LAC++ N+
Sbjct: 155 GHSEICHFLLDHGADVNS-RNKSGRTALMLACEIGSSNA 192
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/116 (34%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 AALNGDLGRVKHLI-QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
A NGD +V L+ +K ++ DS G TA H A+ GH + ++ G AQ
Sbjct: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
G +ALH A+ H E R LL VD G T+LH AA +G +L +H
Sbjct: 78 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 133
Score = 57.8 bits (138), Expect = 5e-09
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 33/163 (20%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS-------- 72
GV T ++ + AA N ++ L+Q DS+G TALHYA+
Sbjct: 68 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 127
Query: 73 -------------------------RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
+NGH +C FLL+ GA +++ G TAL A
Sbjct: 128 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 187
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G + L+ G++ +VD G +LH + + I SLLL
Sbjct: 188 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 230
Score = 33.9 bits (76), Expect = 0.080
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 13 CSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS 72
C H S + L+++D + A NG L+ D + + +G TAL A
Sbjct: 131 CEHKSPI-----NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 185
Query: 73 RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
G + L++ GA + G ALH + + I LLLS
Sbjct: 186 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 231
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 73.6 bits (179), Expect = 9e-14
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G T + + + AA G + ++ +I D + D+ G++ALH A++N H+
Sbjct: 43 GASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI 102
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL+S ++ G TALH A+ G + ++L H S + D DG L A +
Sbjct: 103 RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 162
Query: 141 GHGDICSLLLQHSPALKAIRDRKAR----LACDLLPCNS 175
GH +IC LL H + + R++ R LAC++ N+
Sbjct: 163 GHSEICHFLLDHGADVNS-RNKSGRTALMLACEIGSSNA 200
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/116 (34%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 AALNGDLGRVKHLI-QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
A NGD +V L+ +K ++ DS G TA H A+ GH + ++ G AQ
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
G +ALH A+ H E R LL VD G T+LH AA +G +L +H
Sbjct: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Score = 57.8 bits (138), Expect = 5e-09
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 33/163 (20%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS-------- 72
GV T ++ + AA N ++ L+Q DS+G TALHYA+
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 73 -------------------------RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
+NGH +C FLL+ GA +++ G TAL A
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G + L+ G++ +VD G +LH + + I SLLL
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
Score = 33.9 bits (76), Expect = 0.080
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 13 CSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS 72
C H S + L+++D + A NG L+ D + + +G TAL A
Sbjct: 139 CEHKSPI-----NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
Query: 73 RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
G + L++ GA + G ALH + + I LLLS
Sbjct: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 73.6 bits (179), Expect = 9e-14
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G T + + + AA G + ++ +I D + D+ G++ALH A++N H+
Sbjct: 43 GASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI 102
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL+S ++ G TALH A+ G + ++L H S + D DG L A +
Sbjct: 103 RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 162
Query: 141 GHGDICSLLLQHSPALKAIRDRKAR----LACDLLPCNS 175
GH +IC LL H + + R++ R LAC++ N+
Sbjct: 163 GHSEICHFLLDHGADVNS-RNKSGRTALMLACEIGSSNA 200
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/116 (34%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 AALNGDLGRVKHLI-QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
A NGD +V L+ +K ++ DS G TA H A+ GH + ++ G AQ
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
G +ALH A+ H E R LL VD G T+LH AA +G +L +H
Sbjct: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Score = 57.8 bits (138), Expect = 5e-09
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 33/163 (20%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS-------- 72
GV T ++ + AA N ++ L+Q DS+G TALHYA+
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 73 -------------------------RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
+NGH +C FLL+ GA +++ G TAL A
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G + L+ G++ +VD G +LH + + I SLLL
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
Score = 33.9 bits (76), Expect = 0.080
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 13 CSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS 72
C H S + L+++D + A NG L+ D + + +G TAL A
Sbjct: 139 CEHKSPI-----NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
Query: 73 RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
G + L++ GA + G ALH + + I LLLS
Sbjct: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 73.6 bits (179), Expect = 9e-14
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G T + + + AA G + ++ +I D + D+ G++ALH A++N H+
Sbjct: 43 GASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI 102
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL+S ++ G TALH A+ G + ++L H S + D DG L A +
Sbjct: 103 RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 162
Query: 141 GHGDICSLLLQHSPALKAIRDRKAR----LACDLLPCNS 175
GH +IC LL H + + R++ R LAC++ N+
Sbjct: 163 GHSEICHFLLDHGADVNS-RNKSGRTALMLACEIGSSNA 200
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/116 (34%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 AALNGDLGRVKHLI-QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
A NGD +V L+ +K ++ DS G TA H A+ GH + ++ G AQ
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
G +ALH A+ H E R LL VD G T+LH AA +G +L +H
Sbjct: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Score = 57.8 bits (138), Expect = 5e-09
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 33/163 (20%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS-------- 72
GV T ++ + AA N ++ L+Q DS+G TALHYA+
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 73 -------------------------RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
+NGH +C FLL+ GA +++ G TAL A
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G + L+ G++ +VD G +LH + + I SLLL
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
Score = 33.9 bits (76), Expect = 0.080
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 13 CSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS 72
C H S + L+++D + A NG L+ D + + +G TAL A
Sbjct: 139 CEHKSPI-----NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
Query: 73 RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
G + L++ GA + G ALH + + I LLLS
Sbjct: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 73.6 bits (179), Expect = 9e-14
Identities = 46/159 (28%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVC 80
G T + + + AA G + ++ +I D + D+ G++ALH A++N H+
Sbjct: 43 GASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECI 102
Query: 81 QFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAER 140
+ LL+S ++ G TALH A+ G + ++L H S + D DG L A +
Sbjct: 103 RKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 162
Query: 141 GHGDICSLLLQHSPALKAIRDRKAR----LACDLLPCNS 175
GH +IC LL H + + R++ R LAC++ N+
Sbjct: 163 GHSEICHFLLDHGADVNS-RNKSGRTALMLACEIGSSNA 200
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/116 (34%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 AALNGDLGRVKHLI-QKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHG 96
A NGD +V L+ +K ++ DS G TA H A+ GH + ++ G AQ
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 97 GATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
G +ALH A+ H E R LL VD G T+LH AA +G +L +H
Sbjct: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
Score = 57.8 bits (138), Expect = 5e-09
Identities = 44/163 (26%), Positives = 66/163 (40%), Gaps = 33/163 (20%)
Query: 21 GVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS-------- 72
GV T ++ + AA N ++ L+Q DS+G TALHYA+
Sbjct: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
Query: 73 -------------------------RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYC 107
+NGH +C FLL+ GA +++ G TAL A
Sbjct: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
Query: 108 GHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLL 150
G + L+ G++ +VD G +LH + + I SLLL
Sbjct: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
Score = 33.9 bits (76), Expect = 0.080
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 5/106 (4%)
Query: 13 CSHPSAVLGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYAS 72
C H S + L+++D + A NG L+ D + + +G TAL A
Sbjct: 139 CEHKSPI-----NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
Query: 73 RNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLS 118
G + L++ GA + G ALH + + I LLLS
Sbjct: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 73.6 bits (179), Expect = 9e-14
Identities = 41/106 (38%), Positives = 60/106 (56%)
Query: 32 ERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCD 91
E + AA+ GD R+K LI + D + D AG+TALH A G+Y V + LL +GA+ +
Sbjct: 169 ETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVN 228
Query: 92 AQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKA 137
+ T LH A+ GH ++ +LLL +G NP+ + G T L A
Sbjct: 229 TKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA 274
Score = 53.9 bits (128), Expect = 7e-08
Identities = 34/91 (37%), Positives = 50/91 (54%), Gaps = 4/91 (4%)
Query: 64 GYTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGS-- 121
G T LH A+ G + L+ GA + + G TALH A G+ ++A+ LL+ G+
Sbjct: 168 GETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEV 227
Query: 122 NPRVVDDDGMTSLHKAAERGHGDICSLLLQH 152
N + +DDD T LH AA GH + LLL++
Sbjct: 228 NTKGLDDD--TPLHDAANNGHYKVVKLLLRY 256
Score = 43.9 bits (102), Expect = 8e-05
Identities = 23/62 (37%), Positives = 34/62 (54%)
Query: 89 KCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSL 148
K + + G T LHRA+ G + L+S G++ V D G T+LH+A RG+ D+
Sbjct: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
Query: 149 LL 150
LL
Sbjct: 220 LL 221
>gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
Length = 448
Score = 73.6 bits (179), Expect = 9e-14
Identities = 44/130 (33%), Positives = 67/130 (51%), Gaps = 1/130 (0%)
Query: 29 MDFERGIWSAALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGA 88
+D + + AA G V+ L+ P D G + LH A++ GHY+ + LL +G
Sbjct: 4 VDLGKRLLEAARKGQDDEVRTLMANGA-PFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGV 62
Query: 89 KCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSL 148
DA+T T LH A+ GH I LL+ +G++ D MT+LH A ER H D+ L
Sbjct: 63 SRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVEL 122
Query: 149 LLQHSPALKA 158
L+++ + A
Sbjct: 123 LIKYGADVHA 132
Score = 43.5 bits (101), Expect = 1e-04
Identities = 23/84 (27%), Positives = 44/84 (52%)
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRV 125
T LH A+ +GH + + L+ +GA +A+ TALH A+ H ++ LL+ +G++
Sbjct: 73 TPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHA 132
Query: 126 VDDDGMTSLHKAAERGHGDICSLL 149
++ A E+ + +I +L
Sbjct: 133 FSKFDKSAFDIALEKNNAEILVIL 156
Score = 32.7 bits (73), Expect = 0.18
Identities = 23/79 (29%), Positives = 37/79 (46%)
Query: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
AA +G V+ L++ D + D TALH+A+ H V + L++ GA A +
Sbjct: 78 AAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFD 137
Query: 98 ATALHRASYCGHTEIARLL 116
+A A + EI +L
Sbjct: 138 KSAFDIALEKNNAEILVIL 156
>gi|42734375 ankyrin repeat and sterile alpha motif domain
containing 3 [Homo sapiens]
Length = 656
Score = 73.6 bits (179), Expect = 9e-14
Identities = 47/132 (35%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 20 LGVQQTLEEMDFERGIWSAALNGDLGRVKHLIQKAE-DPSQPDSAGYTALHYASRNGHYA 78
LG Q + EE+D + +AA G VK +Q+ E D ++ + G+T L YAS GH
Sbjct: 24 LGTQVSGEELDVPLDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDT 83
Query: 79 VCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAA 138
+ LLE+G + T G T L AS CG+ IA LL G+ + D G T+L
Sbjct: 84 IVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCT 143
Query: 139 ERGHGDICSLLL 150
GH + LL
Sbjct: 144 SAGHQHMVRFLL 155
Score = 58.9 bits (141), Expect = 2e-09
Identities = 36/108 (33%), Positives = 56/108 (51%), Gaps = 1/108 (0%)
Query: 50 LIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTH-GGATALHRASYCG 108
L+Q+ + D G+TAL + + GH + +FLL+SGA + + G T L A+ G
Sbjct: 121 LLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLDSGANANVREPICGFTPLMEAAAAG 180
Query: 109 HTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLLLQHSPAL 156
H I + L+HG D G T+ A + GH I +L+ +SP+L
Sbjct: 181 HEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALMDTYSPSL 228
Score = 45.1 bits (105), Expect = 3e-05
Identities = 34/111 (30%), Positives = 51/111 (45%), Gaps = 7/111 (6%)
Query: 12 CCSHPSAVLGVQQTLE-EMDFERGIWSAALNGDLGRVKHLIQKAEDPS-----QPDSAGY 65
C + A +QQ E EM +G W+A + +H+++ D + G+
Sbjct: 112 CGNESIAYFLLQQGAELEMKDIQG-WTALFHCTSAGHQHMVRFLLDSGANANVREPICGF 170
Query: 66 TALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLL 116
T L A+ GH + Q+ L G K DA+ H GATA A GH +I L+
Sbjct: 171 TPLMEAAAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIVALM 221
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,861,435
Number of Sequences: 37866
Number of extensions: 332120
Number of successful extensions: 3402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 365
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 756
Number of HSP's gapped (non-prelim): 1792
length of query: 183
length of database: 18,247,518
effective HSP length: 96
effective length of query: 87
effective length of database: 14,612,382
effective search space: 1271277234
effective search space used: 1271277234
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.