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Search of human proteins with 156104869
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156104869 chloride channel 2 [Homo sapiens]
(898 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156104869 chloride channel 2 [Homo sapiens] 1781 0.0
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 869 0.0
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 543 e-154
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 541 e-154
gi|155969705 chloride channel Kb [Homo sapiens] 530 e-150
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 224 2e-58
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 224 2e-58
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 224 2e-58
gi|153252026 chloride channel 4 [Homo sapiens] 220 4e-57
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 216 8e-56
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 216 8e-56
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 191 2e-48
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 191 2e-48
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 165 2e-40
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 98 4e-20
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 67 6e-11
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 67 6e-11
gi|46397390 pogo transposable element with ZNF domain isoform 1 ... 39 0.028
gi|46397394 pogo transposable element with ZNF domain isoform 2 ... 39 0.028
gi|31652259 melanoma ubiquitous mutated protein [Homo sapiens] 35 0.31
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 34 0.53
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 34 0.53
gi|222080092 WD repeat domain 91 [Homo sapiens] 33 0.91
gi|113421234 PREDICTED: similar to NG5 protein [Homo sapiens] 33 1.2
gi|113420954 PREDICTED: similar to NG5 protein [Homo sapiens] 33 1.2
gi|164607124 Fanconi anemia, complementation group I isoform 1 [... 33 1.6
gi|82830440 Fanconi anemia, complementation group I isoform 2 [H... 33 1.6
gi|118498345 AT-binding transcription factor 1 [Homo sapiens] 33 1.6
gi|26051262 potassium voltage-gated channel KQT-like protein 2 i... 32 2.0
gi|26051260 potassium voltage-gated channel KQT-like protein 2 i... 32 2.0
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 1781 bits (4613), Expect = 0.0
Identities = 898/898 (100%), Positives = 898/898 (100%)
Query: 1 MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPE 60
MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPE
Sbjct: 1 MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPE 60
Query: 61 LLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQ 120
LLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQ
Sbjct: 61 LLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQ 120
Query: 121 WMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYL 180
WMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYL
Sbjct: 121 WMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYL 180
Query: 181 TLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEML 240
TLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEML
Sbjct: 181 TLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEML 240
Query: 241 AAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEE 300
AAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEE
Sbjct: 241 AAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEE 300
Query: 301 TITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLM 360
TITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLM
Sbjct: 301 TITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLM 360
Query: 361 RKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPST 420
RKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPST
Sbjct: 361 RKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPST 420
Query: 421 SQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAW 480
SQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAW
Sbjct: 421 SQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAW 480
Query: 481 FPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVIL 540
FPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVIL
Sbjct: 481 FPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVIL 540
Query: 541 ANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDL 600
ANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDL
Sbjct: 541 ANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDL 600
Query: 601 RLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPL 660
RLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPL
Sbjct: 601 RLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPL 660
Query: 661 SDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESA 720
SDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESA
Sbjct: 661 SDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESA 720
Query: 721 GIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLD 780
GIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLD
Sbjct: 721 GIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLD 780
Query: 781 EPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 840
EPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE
Sbjct: 781 EPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 840
Query: 841 GSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ 898
GSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
Sbjct: 841 GSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ 898
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 869 bits (2246), Expect = 0.0
Identities = 460/809 (56%), Positives = 573/809 (70%), Gaps = 19/809 (2%)
Query: 70 ARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTS 129
++C+ C R + + ++GEDWIFLVLLGLLMALVSW MDY A LQA +W + S
Sbjct: 97 SKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPS 156
Query: 130 ILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKV 189
+ LQ+L WVT+P+VLI FSA F +++PQAVGSGIPEMKTILRGVVLKEYLT+K F+AKV
Sbjct: 157 LPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKV 216
Query: 190 IGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVG 249
+ LT LGSG+P+GKEGPFVHIAS+CAA+LSKF+S+F G+YE +++L CAVGVG
Sbjct: 217 VALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVG 276
Query: 250 CCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTR 309
CCF P+GGVLFSIEVTST+FAVRNYWRGFFAATFSAF+FRVLAVWN+D TITALF+T
Sbjct: 277 CCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTN 336
Query: 310 FRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPAL 369
FR+DFPFDL+ELPAFA IGI G GA+FVYL+R+++ +RK K +++FL + RLL+P +
Sbjct: 337 FRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGI 396
Query: 370 VTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRA 429
VT +I++ TFPPG GQFMAG+L +E + TLFDN TWV+ + E S W PR
Sbjct: 397 VTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKH--AGDPESLGQSAVWIHPRV 454
Query: 430 NVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDS 489
NV + + +F +MKFWMS +ATT+P+PCG FMPVFV+GAAFGRLVGE MA FPDGI D
Sbjct: 455 NVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDD 514
Query: 490 STYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQ 549
Y+I+PGGYAV+GAAAL GAV+HTVSTAVI FELTGQIAHILP+M+AVILAN VAQSLQ
Sbjct: 515 IIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQ 574
Query: 550 PSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKG 609
PSLYDSII++KKLPYLP+LGW + +Y + VEDIMVRDV V+ S T+ +LR L T
Sbjct: 575 PSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTV 634
Query: 610 RMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQE-RRATQTSPLSDQ----- 663
+ L LV+S +SMILLGS+ERS++ ALL L P RR + QE R P +
Sbjct: 635 KTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAG 694
Query: 664 EG----PPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLG-ESPTGSAE 718
EG PP S F ED G++ P P+L PS T L E P G
Sbjct: 695 EGLPGAPPGRPESFAFVDEDEDEDL---SGKSELP--PSLALHPSTTAPLSPEEPNGPLP 749
Query: 719 SAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQ 778
+ P L R + + DL MSPEEI WE++Q
Sbjct: 750 GHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQ 809
Query: 779 LDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKA 838
L +PV F C ID +PFQLVE+T+LHKTHT+FSLLG+ AYVTS+G+L G++ L+EL+KA
Sbjct: 810 LSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKA 869
Query: 839 IEGSVTAQGVKVRPPLASFRDSATSSSDT 867
IEG T GV++RPPLASFR++ ++ T
Sbjct: 870 IEGH-TKSGVQLRPPLASFRNTTSTRKST 897
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 543 bits (1400), Expect = e-154
Identities = 283/575 (49%), Positives = 387/575 (67%), Gaps = 9/575 (1%)
Query: 84 VSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVV 143
V R+GEDW FL+ LG+LMALVS+ M++AI ++A QW+ R + S LL+YL+W YPV
Sbjct: 43 VFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
Query: 144 LITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMP 201
L++FS+GF+Q + P + GSGIPE+KT+L GV+L++YL +K F AKV+GL+C L GS +
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
Query: 202 LGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLF 261
LGK GPFVH++ M AA L + + G EN+S+ EML AA AVGV FAAP GVLF
Sbjct: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLF 222
Query: 262 SIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQEL 321
SIEV S+ F+VR+YWRGFFAAT AFIFR+LAV+N ++ETIT+L+KT FR+D PFDL E+
Sbjct: 223 SIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEI 282
Query: 322 PAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPP 381
F +G G +++ R + ++ + ++ L + ++ AL TLL++++T+PP
Sbjct: 283 FFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPP 342
Query: 382 GFGQFMAGQLSQKETLVTLFDNRTWVRQGL------VEELEPPSTSQAWNPPRANVFLTL 435
G G F+A +LS K+ L +LFDN +W EEL+P W PR +F TL
Sbjct: 343 GVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTL 402
Query: 436 VIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIV 495
F++MKFWM LATTIP+P G FMP+F++GAA GRL+GE++A FP+GI T T I+
Sbjct: 403 AFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIM 462
Query: 496 PGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDS 555
PGGYA+ GAAA +GAVTHT+STA++ FELTGQI H LPV++AV+ ANA+AQS QPS YD
Sbjct: 463 PGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDG 522
Query: 556 IIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALV 615
I +KKLPYLP + + VRVE M + +A ++ + T LV
Sbjct: 523 TIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLV 582
Query: 616 ESPESMILLGSIERSQVVALLGAQLSPARRRQHMQ 650
ES ES IL+G ++R+Q+V L A+ P+R H Q
Sbjct: 583 ESTESQILVGIVQRAQLVQALQAE-PPSRAPGHQQ 616
Score = 45.8 bits (107), Expect = 2e-04
Identities = 22/63 (34%), Positives = 34/63 (53%)
Query: 777 QQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELR 836
QQ + + C +P L T+LH+ +F LL + +VTS GR +G V+ E++
Sbjct: 615 QQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMK 674
Query: 837 KAI 839
KAI
Sbjct: 675 KAI 677
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 541 bits (1395), Expect = e-154
Identities = 282/573 (49%), Positives = 386/573 (67%), Gaps = 9/573 (1%)
Query: 84 VSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVV 143
V R+GEDW FL+ LG+LMALVS+ M++AI ++A QW+ R + S LL+YL+W YPV
Sbjct: 43 VFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
Query: 144 LITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMP 201
L++FS+GF+Q + P + GSGIPE+KT+L GV+L++YL +K F AKV+GL+C L GS +
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
Query: 202 LGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLF 261
LGK GPFVH++ M AA L + + G EN+S+ EML AA AVGV FAAP GVLF
Sbjct: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLF 222
Query: 262 SIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQEL 321
SIEV S+ F+VR+YWRGFFAAT AFIFR+LAV+N ++ETIT+L+KT FR+D PFDL E+
Sbjct: 223 SIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEI 282
Query: 322 PAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPP 381
F +G G +++ R + ++ + ++ L + ++ AL TLL++++T+PP
Sbjct: 283 FFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPP 342
Query: 382 GFGQFMAGQLSQKETLVTLFDNRTWVRQGL------VEELEPPSTSQAWNPPRANVFLTL 435
G G F+A +LS K+ L +LFDN +W EEL+P W PR +F TL
Sbjct: 343 GVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTL 402
Query: 436 VIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIV 495
F++MKFWM LATTIP+P G FMP+F++GAA GRL+GE++A FP+GI T T I+
Sbjct: 403 AFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIM 462
Query: 496 PGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDS 555
PGGYA+ GAAA +GAVTHT+STA++ FELTGQI H LPV++AV+ ANA+AQS QPS YD
Sbjct: 463 PGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDG 522
Query: 556 IIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALV 615
I +KKLPYLP + + VRVE M + +A ++ + T LV
Sbjct: 523 TIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLV 582
Query: 616 ESPESMILLGSIERSQVVALLGAQLSPARRRQH 648
ES ES IL+G ++R+Q+V L A+ P+R H
Sbjct: 583 ESTESQILVGIVQRAQLVQALQAE-PPSRAPGH 614
Score = 45.1 bits (105), Expect = 3e-04
Identities = 20/52 (38%), Positives = 30/52 (57%)
Query: 788 CKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839
C +P L T+LH+ +F LL + +VTS GR +G V+ E++KAI
Sbjct: 625 CPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAI 676
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 530 bits (1365), Expect = e-150
Identities = 289/619 (46%), Positives = 398/619 (64%), Gaps = 16/619 (2%)
Query: 86 RVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLI 145
R+GEDW FL+ LG+LMALVS MD A+ + ++A QW+ R + S LL+YL+W YPV L+
Sbjct: 45 RLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALV 104
Query: 146 TFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLG 203
+FS+GF+Q + P + GSGIPE+KT+L GVVL++YL +K F AKV+GL+C L GS + LG
Sbjct: 105 SFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLG 164
Query: 204 KEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSI 263
K GPFVH++ M AA L + + G EN+S+ EML AA AVGV FAAP GVLFSI
Sbjct: 165 KVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSI 224
Query: 264 EVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPA 323
EV S+ F+V +YWRGFFAAT AF+FR+LAV+N ++ETIT+L+KT FR+D PFDL E+
Sbjct: 225 EVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFF 284
Query: 324 FAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGF 383
F +G G G+ +++ R +R + ++ L + ++ AL TL+++++T+PP
Sbjct: 285 FVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSA 344
Query: 384 GQFMAGQLSQKETLVTLFDNRTWVRQGL------VEELEPPSTSQAWNPPRANVFLTLVI 437
G+F+A +LS K+ L +LFDN +W EEL+P W PR +F TL
Sbjct: 345 GRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAF 404
Query: 438 FILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPG 497
F++MKFWM LATTIP+P G FMP+FV GAA GRL GE+++ FP+GI T I+PG
Sbjct: 405 FLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPG 464
Query: 498 GYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSII 557
GYA+ GAAA +GAVTHT+STA++ FE+TGQI H LPV++AV+ ANA+AQS QPS YD +
Sbjct: 465 GYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTV 524
Query: 558 RIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVES 617
+KKLPYLP + +RVRVE M + +A ++ + T LVES
Sbjct: 525 IVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVES 584
Query: 618 PESMILLGSIERSQVVALLGAQLSPARRRQHMQ-----ERRATQTSPLSDQEGPPTP--E 670
ES IL+G + R+Q+V L A+ P+ H Q T P++ + P T E
Sbjct: 585 TESQILVGIVRRAQLVQALKAE-PPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHE 643
Query: 671 ASVCFQVNTEDSAFPAARG 689
A F++ S F +RG
Sbjct: 644 AHNLFELLNLHSLFVTSRG 662
Score = 50.4 bits (119), Expect = 7e-06
Identities = 24/63 (38%), Positives = 37/63 (58%)
Query: 777 QQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELR 836
QQ + + + C +P +L TSLH+ H +F LL + +VTS GR +G V+ E++
Sbjct: 615 QQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMK 674
Query: 837 KAI 839
KAI
Sbjct: 675 KAI 677
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 224 bits (572), Expect = 2e-58
Identities = 174/558 (31%), Positives = 269/558 (48%), Gaps = 47/558 (8%)
Query: 115 CLQAQQWMSRGLNT-----SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKT 169
C + W ++T + ++ Y +V + ++ + ++ AP A GSGIPE+KT
Sbjct: 186 CPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKT 245
Query: 170 ILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGI 229
IL G +++ YL T + K I L A+ SG+ LGKEGP VH+A C +L F
Sbjct: 246 ILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNIL---CHCFNKY 302
Query: 230 YENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIF 289
+NE++ E+L+AA A GV F APIGGVLFS+E S +F ++ WR FFAA +AF
Sbjct: 303 RKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL 362
Query: 290 RVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVM 349
R + N + LF F P+ L EL F ++GI G GALF+ N +
Sbjct: 363 RSI---NPFGNSRLVLFYVEFHT--PWHLFELVPFILLGIFGGLWGALFIRTN---IAWC 414
Query: 350 RKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQ 409
RK+KT L + ++ +VT + + L FP + ++S E + LF++ +
Sbjct: 415 RKRKTTQ--LGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDS 467
Query: 410 GLVEELEPP-STSQAWNPPRA-------NVFLTLVIFILMKFWMSALATTIPVPCGAFMP 461
+ + E +TS+ P + L + +++K ++ + +P G F+P
Sbjct: 468 SKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 527
Query: 462 VFVIGAAFGRLVGESM-------AAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH- 513
+GA GRL+G M W I PG YA+VGAAA G VT
Sbjct: 528 SMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 587
Query: 514 TVSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGR 572
TVS VI+FELTG + +I+P+M A + + VA +L + +YD+ IR+ P+L
Sbjct: 588 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFA 647
Query: 573 HQQYRVRVEDIMVRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLGSIER 629
H+ + V D L S T D+ + T +V S ES L+G + R
Sbjct: 648 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLR 707
Query: 630 SQVVALLGAQLSPARRRQ 647
++ + AR++Q
Sbjct: 708 RDLI----ISIENARKKQ 721
Score = 37.0 bits (84), Expect = 0.082
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839
+D +PF + + T + IF LG+ VT GRL+GI+T K++ K I
Sbjct: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 224 bits (572), Expect = 2e-58
Identities = 174/558 (31%), Positives = 269/558 (48%), Gaps = 47/558 (8%)
Query: 115 CLQAQQWMSRGLNT-----SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKT 169
C + W ++T + ++ Y +V + ++ + ++ AP A GSGIPE+KT
Sbjct: 186 CPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKT 245
Query: 170 ILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGI 229
IL G +++ YL T + K I L A+ SG+ LGKEGP VH+A C +L F
Sbjct: 246 ILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNIL---CHCFNKY 302
Query: 230 YENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIF 289
+NE++ E+L+AA A GV F APIGGVLFS+E S +F ++ WR FFAA +AF
Sbjct: 303 RKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL 362
Query: 290 RVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVM 349
R + N + LF F P+ L EL F ++GI G GALF+ N +
Sbjct: 363 RSI---NPFGNSRLVLFYVEFHT--PWHLFELVPFILLGIFGGLWGALFIRTN---IAWC 414
Query: 350 RKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQ 409
RK+KT L + ++ +VT + + L FP + ++S E + LF++ +
Sbjct: 415 RKRKTTQ--LGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDS 467
Query: 410 GLVEELEPP-STSQAWNPPRA-------NVFLTLVIFILMKFWMSALATTIPVPCGAFMP 461
+ + E +TS+ P + L + +++K ++ + +P G F+P
Sbjct: 468 SKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 527
Query: 462 VFVIGAAFGRLVGESM-------AAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH- 513
+GA GRL+G M W I PG YA+VGAAA G VT
Sbjct: 528 SMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 587
Query: 514 TVSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGR 572
TVS VI+FELTG + +I+P+M A + + VA +L + +YD+ IR+ P+L
Sbjct: 588 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFA 647
Query: 573 HQQYRVRVEDIMVRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLGSIER 629
H+ + V D L S T D+ + T +V S ES L+G + R
Sbjct: 648 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLR 707
Query: 630 SQVVALLGAQLSPARRRQ 647
++ + AR++Q
Sbjct: 708 RDLI----ISIENARKKQ 721
Score = 37.0 bits (84), Expect = 0.082
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839
+D +PF + + T + IF LG+ VT GRL+GI+T K++ K I
Sbjct: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 224 bits (572), Expect = 2e-58
Identities = 174/558 (31%), Positives = 269/558 (48%), Gaps = 47/558 (8%)
Query: 115 CLQAQQWMSRGLNT-----SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKT 169
C + W ++T + ++ Y +V + ++ + ++ AP A GSGIPE+KT
Sbjct: 116 CPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKT 175
Query: 170 ILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGI 229
IL G +++ YL T + K I L A+ SG+ LGKEGP VH+A C +L F
Sbjct: 176 ILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNIL---CHCFNKY 232
Query: 230 YENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIF 289
+NE++ E+L+AA A GV F APIGGVLFS+E S +F ++ WR FFAA +AF
Sbjct: 233 RKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL 292
Query: 290 RVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVM 349
R + N + LF F P+ L EL F ++GI G GALF+ N +
Sbjct: 293 RSI---NPFGNSRLVLFYVEFHT--PWHLFELVPFILLGIFGGLWGALFIRTN---IAWC 344
Query: 350 RKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQ 409
RK+KT L + ++ +VT + + L FP + ++S E + LF++ +
Sbjct: 345 RKRKTTQ--LGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDS 397
Query: 410 GLVEELEPP-STSQAWNPPRA-------NVFLTLVIFILMKFWMSALATTIPVPCGAFMP 461
+ + E +TS+ P + L + +++K ++ + +P G F+P
Sbjct: 398 SKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIP 457
Query: 462 VFVIGAAFGRLVGESM-------AAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH- 513
+GA GRL+G M W I PG YA+VGAAA G VT
Sbjct: 458 SMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRM 517
Query: 514 TVSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGR 572
TVS VI+FELTG + +I+P+M A + + VA +L + +YD+ IR+ P+L
Sbjct: 518 TVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFA 577
Query: 573 HQQYRVRVEDIMVRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLGSIER 629
H+ + V D L S T D+ + T +V S ES L+G + R
Sbjct: 578 HKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLR 637
Query: 630 SQVVALLGAQLSPARRRQ 647
++ + AR++Q
Sbjct: 638 RDLI----ISIENARKKQ 651
Score = 37.0 bits (84), Expect = 0.082
Identities = 19/50 (38%), Positives = 29/50 (58%)
Query: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839
+D +PF + + T + IF LG+ VT GRL+GI+T K++ K I
Sbjct: 683 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 732
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 220 bits (561), Expect = 4e-57
Identities = 181/620 (29%), Positives = 293/620 (47%), Gaps = 88/620 (14%)
Query: 91 WIFLVLLGLLMALVSWVMDYAI--------AACLQA------------------------ 118
W+ ++L+GLL ++ V+D A+ CL A
Sbjct: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
Query: 119 --QQWMSRGLNTS-----ILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTIL 171
Q+W +N S +L YL ++ + ++ + ++ AP A GSGIPE+KTIL
Sbjct: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
Query: 172 RGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYE 231
G +++ YL T + K + L + SG+ LGKEGP VH+A C + F SLF +
Sbjct: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG---NFFSSLFSKYSK 247
Query: 232 NESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRV 291
NE + E+L+AA A GV F APIGGVLFS+E S +F ++ WR FFAA +AF R
Sbjct: 248 NEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRS 307
Query: 292 LAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRK 351
+ N + LF + P+ + EL F ++G+ G G LF+ N + R+
Sbjct: 308 I---NPFGNSRLVLFYVEYHT--PWYMAELFPFILLGVFGGLWGTLFIRCN---IAWCRR 359
Query: 352 QKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQG- 410
+KT L + +L +VT + + + +P + + S E + LF++ +
Sbjct: 360 RKTTR--LGKYPVLEVIVVTAITAIIAYPNPY-----TRQSTSELISELFNDCGALESSQ 412
Query: 411 LVEELEPPSTSQAWN-----PPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPV 462
L + + P+ ++ + P V+ L + ++ K ++ + +P G F+P
Sbjct: 413 LCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPS 472
Query: 463 FVIGAAFGRLVG---ESMAAWFPDGI----HTDSSTYRIVPGGYAVVGAAALAGAVTH-T 514
+GA GR+VG E +A D I + PG YA+VGAAA G VT T
Sbjct: 473 MAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMT 532
Query: 515 VSTAVIVFELTGQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRH 573
VS VI+FELTG + +I+P+M A + + VA + + +Y++ I + P+L H
Sbjct: 533 VSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTH 592
Query: 574 QQYRVRVEDIM--VRDVPHVAL----SCTFRDLRLALHRTKGRMLALVESPESMILLGSI 627
R D+M R P +++ S T D+ + T +V S +S L+G
Sbjct: 593 ---RTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFA 649
Query: 628 ERSQVVALLGAQLSPARRRQ 647
+R +++ + AR+RQ
Sbjct: 650 QRRELI----LAIKNARQRQ 665
Score = 35.0 bits (79), Expect = 0.31
Identities = 16/43 (37%), Positives = 25/43 (58%)
Query: 793 APFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKEL 835
+PF + + T + IF LG+ VT GRL+GI+T K++
Sbjct: 700 SPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDV 742
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 216 bits (550), Expect = 8e-56
Identities = 172/539 (31%), Positives = 259/539 (48%), Gaps = 52/539 (9%)
Query: 129 SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAK 188
S ++ Y+ ++ + + + ++ AP A GSGIPE+KTIL G +++ YL T + K
Sbjct: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
Query: 189 VIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGV 248
I L A+ SG+ LGKEGP VH+A C + F LF NE++ E+L+AA A GV
Sbjct: 266 TITLVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGV 322
Query: 249 GCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKT 308
F APIGGVLFS+E S +F ++ WR FFAA +AF+ R + N + LF
Sbjct: 323 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---NPFGNSRLVLFYV 379
Query: 309 RFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368
+ P+ L EL F ++G+ G GA F+ N I R++ T K +P
Sbjct: 380 EYHT--PWYLFELFPFILLGVFGGLWGAFFIRAN--IAWCRRRKST-------KFGKYPV 428
Query: 369 LVTLLISTLT----FPPGFGQFMAGQLSQKETLV--------TLFDNRTWVRQGLVEELE 416
L ++++ +T FP + + +L KE +L D R + + +
Sbjct: 429 LEVIIVAAITAVIAFPNPYTRLNTSELI-KELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
Query: 417 PPSTSQAWNPPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 473
P P V+ L + ++ K M+ I VP G F+P IGA GR+V
Sbjct: 488 PD------RPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIV 541
Query: 474 G---ESMA----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELT 525
G E +A WF + I PG YA+VGAAA G VT TVS VIVFELT
Sbjct: 542 GIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601
Query: 526 GQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIM 584
G + +I+P+M AV+ + V + + +Y++ IR+ P+L H V
Sbjct: 602 GGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPR 661
Query: 585 VRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLG-SIERSQVVALLGAQ 639
D P L + T D+ ++ T ++ S ES L+G ++ R +A+ A+
Sbjct: 662 RNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
Score = 33.1 bits (74), Expect = 1.2
Identities = 16/51 (31%), Positives = 28/51 (54%)
Query: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 840
+D +PF + + T + IF LG+ VT G ++GI+T K + + +E
Sbjct: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLE 805
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 216 bits (550), Expect = 8e-56
Identities = 172/539 (31%), Positives = 259/539 (48%), Gaps = 52/539 (9%)
Query: 129 SILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAK 188
S ++ Y+ ++ + + + ++ AP A GSGIPE+KTIL G +++ YL T + K
Sbjct: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265
Query: 189 VIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGV 248
I L A+ SG+ LGKEGP VH+A C + F LF NE++ E+L+AA A GV
Sbjct: 266 TITLVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGV 322
Query: 249 GCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKT 308
F APIGGVLFS+E S +F ++ WR FFAA +AF+ R + N + LF
Sbjct: 323 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSI---NPFGNSRLVLFYV 379
Query: 309 RFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368
+ P+ L EL F ++G+ G GA F+ N I R++ T K +P
Sbjct: 380 EYHT--PWYLFELFPFILLGVFGGLWGAFFIRAN--IAWCRRRKST-------KFGKYPV 428
Query: 369 LVTLLISTLT----FPPGFGQFMAGQLSQKETLV--------TLFDNRTWVRQGLVEELE 416
L ++++ +T FP + + +L KE +L D R + + +
Sbjct: 429 LEVIIVAAITAVIAFPNPYTRLNTSELI-KELFTDCGPLESSSLCDYRNDMNASKIVDDI 487
Query: 417 PPSTSQAWNPPRANVFLT---LVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 473
P P V+ L + ++ K M+ I VP G F+P IGA GR+V
Sbjct: 488 PD------RPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIV 541
Query: 474 G---ESMA----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELT 525
G E +A WF + I PG YA+VGAAA G VT TVS VIVFELT
Sbjct: 542 GIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601
Query: 526 GQIAHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIM 584
G + +I+P+M AV+ + V + + +Y++ IR+ P+L H V
Sbjct: 602 GGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPR 661
Query: 585 VRDVPHVAL---SCTFRDLRLALHRTKGRMLALVESPESMILLG-SIERSQVVALLGAQ 639
D P L + T D+ ++ T ++ S ES L+G ++ R +A+ A+
Sbjct: 662 RNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR 720
Score = 36.6 bits (83), Expect = 0.11
Identities = 17/46 (36%), Positives = 27/46 (58%)
Query: 790 IDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKEL 835
+D +PF + + T + IF LG+ VT GRL+GI+T K++
Sbjct: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDI 800
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 191 bits (486), Expect = 2e-48
Identities = 165/601 (27%), Positives = 277/601 (46%), Gaps = 60/601 (9%)
Query: 91 WIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRG----------LNTSILLQYLAWVTY 140
W+ L+G+L LV+ +D + + + +G L+ S+LL W T
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLL----WATL 158
Query: 141 PVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGM 200
+ + + P A GSGIP++K L GV + + LKT + KV G+ ++ G+
Sbjct: 159 NAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGL 218
Query: 201 PLGKEGPFVHIASMCAALLSK----FLSLFGGIYENESRNTE---MLAAACAVGVGCCFA 253
+GKEGP +H S+ AA +S+ L I+E R+TE ++A A GV F
Sbjct: 219 AVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFG 278
Query: 254 APIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFR-VLAVWNRDEETITALFKTRF-R 311
AP+GGVLFS+E ++F+ WR FFA+ S F VL++++ + +++ F R
Sbjct: 279 APVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGR 338
Query: 312 LD---FPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368
D + + E+P F +G+ G GA+F LN + M + + I+R + +++
Sbjct: 339 FDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWL--TMFRIRYIHRPCL--QVIEAV 394
Query: 369 LVTLLISTLTFPPGFGQ-----FMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQA 423
LV + +T+ F + G +S L + E S
Sbjct: 395 LVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF 454
Query: 424 WNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPD 483
+PP + LTL +F L+ F+++ + V G F+P +IGAA+GRL G S++
Sbjct: 455 HDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGA 514
Query: 484 GIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILAN 542
I D PG YA++GAAA L G V T+S VI+ E T + + P+M+ ++ A
Sbjct: 515 AIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAK 567
Query: 543 AVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRL 602
V LYD I+++ +P+L H + V + R+V ++C R ++
Sbjct: 568 IVGDVFIEGLYDMHIQLQSVPFL-------HWEAPVTSHSLTAREVMSTPVTCLRRREKV 620
Query: 603 ----------ALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQER 652
A + ++ + + L G I RSQ++ LL ++ R + +R
Sbjct: 621 GVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQR 680
Query: 653 R 653
R
Sbjct: 681 R 681
Score = 31.6 bits (70), Expect = 3.5
Identities = 19/86 (22%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 753 RISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSL 812
R+ L D P + + + + + ++ S+ ++P+P+ + + SL + +F
Sbjct: 681 RLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF-MNPSPYTVPQEASLPRVFKLFRA 739
Query: 813 LGVDH-AYVTSIGRLIGIVTLKELRK 837
LG+ H V + +++G+VT K+L +
Sbjct: 740 LGLRHLVVVDNRNQVVGLVTRKDLAR 765
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 191 bits (486), Expect = 2e-48
Identities = 165/601 (27%), Positives = 277/601 (46%), Gaps = 60/601 (9%)
Query: 91 WIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRG----------LNTSILLQYLAWVTY 140
W+ L+G+L LV+ +D + + + +G L+ S+LL W T
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLL----WATL 182
Query: 141 PVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGM 200
+ + + P A GSGIP++K L GV + + LKT + KV G+ ++ G+
Sbjct: 183 NAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGL 242
Query: 201 PLGKEGPFVHIASMCAALLSK----FLSLFGGIYENESRNTE---MLAAACAVGVGCCFA 253
+GKEGP +H S+ AA +S+ L I+E R+TE ++A A GV F
Sbjct: 243 AVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFG 302
Query: 254 APIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFR-VLAVWNRDEETITALFKTRF-R 311
AP+GGVLFS+E ++F+ WR FFA+ S F VL++++ + +++ F R
Sbjct: 303 APVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGR 362
Query: 312 LD---FPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368
D + + E+P F +G+ G GA+F LN + M + + I+R + +++
Sbjct: 363 FDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWL--TMFRIRYIHRPCL--QVIEAV 418
Query: 369 LVTLLISTLTFPPGFGQ-----FMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQA 423
LV + +T+ F + G +S L + E S
Sbjct: 419 LVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF 478
Query: 424 WNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPD 483
+PP + LTL +F L+ F+++ + V G F+P +IGAA+GRL G S++
Sbjct: 479 HDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGA 538
Query: 484 GIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILAN 542
I D PG YA++GAAA L G V T+S VI+ E T + + P+M+ ++ A
Sbjct: 539 AIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAK 591
Query: 543 AVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRL 602
V LYD I+++ +P+L H + V + R+V ++C R ++
Sbjct: 592 IVGDVFIEGLYDMHIQLQSVPFL-------HWEAPVTSHSLTAREVMSTPVTCLRRREKV 644
Query: 603 ----------ALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQER 652
A + ++ + + L G I RSQ++ LL ++ R + +R
Sbjct: 645 GVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQR 704
Query: 653 R 653
R
Sbjct: 705 R 705
Score = 31.6 bits (70), Expect = 3.5
Identities = 19/86 (22%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 753 RISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSL 812
R+ L D P + + + + + ++ S+ ++P+P+ + + SL + +F
Sbjct: 705 RLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF-MNPSPYTVPQEASLPRVFKLFRA 763
Query: 813 LGVDH-AYVTSIGRLIGIVTLKELRK 837
LG+ H V + +++G+VT K+L +
Sbjct: 764 LGLRHLVVVDNRNQVVGLVTRKDLAR 789
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 165 bits (417), Expect = 2e-40
Identities = 193/832 (23%), Positives = 341/832 (40%), Gaps = 146/832 (17%)
Query: 91 WIFLVLLGLLMALVSWVMDYAIAACLQ---------AQQWMSRGLNTSILLQYLAWVTYP 141
W+ + +G+ LV +D+ + Q ++ +G LL+ L +
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFN--- 137
Query: 142 VVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMP 201
+ F A ++ P A GSGIPE+K L GV + + L+T + KV+G+ ++ G+
Sbjct: 138 -LTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 202 LGKEGPFVHIASMCAALLSKFLSL------FGGIYENESRN-TEMLAAACAVGVGCCFAA 254
+GKEGP +H S+ A L +F S+ F Y R+ + ++A A GV F A
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
Query: 255 PIGGVLFSIEVTSTFFAVRNYWRGFF---AATFSAFIFR---VLAVWNRDEETITALFKT 308
PIGG LFS+E S+F+ W+ F +ATF+ FR W F+
Sbjct: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGS--------FQL 308
Query: 309 RFRLDFP-------------FDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTI 355
L+F + +L F V+G+ G GA F LN+++ + + + +
Sbjct: 309 PGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKY--RMRNV 366
Query: 356 NRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETL--------VTLFDNRTWV 407
+ R+L LV+L+ + + F Q+S + VT N +
Sbjct: 367 HPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIK 426
Query: 408 RQGLVEELEPPSTSQAWNPPRANVF-----------LTLVIFILMKFWMSALATTIPVPC 456
+ + +NP + + +TL +F ++ F ++ I VP
Sbjct: 427 TFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPS 486
Query: 457 GAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTV 515
G F+P + GAAFGRLV + ++ G I G +A++GAAA L G V T+
Sbjct: 487 GLFVPSLLCGAAFGRLVANVLKSYIGLG--------HIYSGTFALIGAAAFLGGVVRMTI 538
Query: 516 STAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRH-Q 574
S VI+ E T +I + LP+M+ +++A +YD + ++ +P L W +
Sbjct: 539 SLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE---WETEVE 595
Query: 575 QYRVRVEDIMVRDV----PHVALSCTFRDLRLALH-------RTKGRMLALVESPESMIL 623
++R DIM ++ PH + LR +H +G ++ + +
Sbjct: 596 MDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISN 655
Query: 624 LGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSA 683
++S ++ G Q +R Q M+ +++ + D+ + +E+ A
Sbjct: 656 NIKFKKSSILTRAGEQ---RKRSQSMKSYPSSELRNMCDE------------HIASEEPA 700
Query: 684 FPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESA-----------GIALRSLF---- 728
E L+ L+R + NL + S + G+ LRS
Sbjct: 701 ------EKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLL 754
Query: 729 ----CGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVN 784
C S +AS+ S + R D DL ++P I++
Sbjct: 755 VRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLT-LLNPRMIVDVTPY------- 806
Query: 785 FSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDH-AYVTSIGRLIGIVTLKEL 835
++P+PF + T + + +F +G+ H V ++G ++GI+T L
Sbjct: 807 -----MNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 97.8 bits (242), Expect = 4e-20
Identities = 67/219 (30%), Positives = 107/219 (48%), Gaps = 23/219 (10%)
Query: 91 WIFLVLLGLLMALVSWVMDYAIAACLQ---------AQQWMSRGLNTSILLQYLAWVTYP 141
W+ + +G+ LV +D+ + Q ++ +G LL+ L +
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFN--- 137
Query: 142 VVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMP 201
+ F A ++ P A GSGIPE+K L GV + + L+T + KV+G+ ++ G+
Sbjct: 138 -LTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 202 LGKEGPFVHIASMCAALLSKFLSL------FGGIYENESRN-TEMLAAACAVGVGCCFAA 254
+GKEGP +H S+ A L +F S+ F Y R+ + ++A A GV F A
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGA 256
Query: 255 PIGGVLFSIEVTSTFFAVRNYWRGFF---AATFSAFIFR 290
PIGG LFS+E S+F+ W+ F +ATF+ FR
Sbjct: 257 PIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFR 295
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 67.4 bits (163), Expect = 6e-11
Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 13/144 (9%)
Query: 91 WIFLVLLGLLMALVSWVMDYAIAACLQ---------AQQWMSRGLNTSILLQYLAWVTYP 141
W+ + +G+ LV +D+ + Q ++ +G LL+ L +
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFN--- 137
Query: 142 VVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMP 201
+ F A ++ P A GSGIPE+K L GV + + L+T + KV+G+ ++ G+
Sbjct: 138 -LTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 202 LGKEGPFVHIASMCAALLSKFLSL 225
+GKEGP +H S+ A L +F S+
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSI 220
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 67.4 bits (163), Expect = 6e-11
Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 13/144 (9%)
Query: 91 WIFLVLLGLLMALVSWVMDYAIAACLQ---------AQQWMSRGLNTSILLQYLAWVTYP 141
W+ + +G+ LV +D+ + Q ++ +G LL+ L +
Sbjct: 81 WMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFN--- 137
Query: 142 VVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMP 201
+ F A ++ P A GSGIPE+K L GV + + L+T + KV+G+ ++ G+
Sbjct: 138 -LTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLF 196
Query: 202 LGKEGPFVHIASMCAALLSKFLSL 225
+GKEGP +H S+ A L +F S+
Sbjct: 197 VGKEGPMIHSGSVVGAGLPQFQSI 220
>gi|46397390 pogo transposable element with ZNF domain isoform 1 [Homo
sapiens]
Length = 1410
Score = 38.5 bits (88), Expect = 0.028
Identities = 44/181 (24%), Positives = 73/181 (40%), Gaps = 34/181 (18%)
Query: 626 SIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTP-------------EAS 672
S ++ + A +PA + + SP S PPTP E +
Sbjct: 878 SFPTNKAATVKSAGATPAEPEELLTPLAPALPSPASTATPPPTPTHPQALALPPLATEGA 937
Query: 673 VCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSP 732
C V+ +D P + +P L G + +G+ S + + L +L C +
Sbjct: 938 ECLNVDDQDEGSPVTQ-------EPELASGGGGSGGVGKKEQLSVKKLRVVLFALCCNT- 989
Query: 733 PPEAASEKLESCEKRKLKRVRISLASDAD-LEGEM----SPEEILEW----EEQQLDEPV 783
E A+E + ++R + +R AS + LEG+ + E++ EW EQQL PV
Sbjct: 990 --EQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEWVLTQREQQL--PV 1045
Query: 784 N 784
N
Sbjct: 1046 N 1046
>gi|46397394 pogo transposable element with ZNF domain isoform 2
[Homo sapiens]
Length = 1357
Score = 38.5 bits (88), Expect = 0.028
Identities = 44/181 (24%), Positives = 73/181 (40%), Gaps = 34/181 (18%)
Query: 626 SIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTP-------------EAS 672
S ++ + A +PA + + SP S PPTP E +
Sbjct: 825 SFPTNKAATVKSAGATPAEPEELLTPLAPALPSPASTATPPPTPTHPQALALPPLATEGA 884
Query: 673 VCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSP 732
C V+ +D P + +P L G + +G+ S + + L +L C +
Sbjct: 885 ECLNVDDQDEGSPVTQ-------EPELASGGGGSGGVGKKEQLSVKKLRVVLFALCCNT- 936
Query: 733 PPEAASEKLESCEKRKLKRVRISLASDAD-LEGEM----SPEEILEW----EEQQLDEPV 783
E A+E + ++R + +R AS + LEG+ + E++ EW EQQL PV
Sbjct: 937 --EQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEWVLTQREQQL--PV 992
Query: 784 N 784
N
Sbjct: 993 N 993
>gi|31652259 melanoma ubiquitous mutated protein [Homo sapiens]
Length = 711
Score = 35.0 bits (79), Expect = 0.31
Identities = 38/136 (27%), Positives = 53/136 (38%), Gaps = 25/136 (18%)
Query: 659 PLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAE 718
PL PP PE S C +E PA + +P +R P+V L G+A
Sbjct: 277 PLGSLTAPPAPEPSAC----SEPGECPAKK----RPRLDGSQRPPAV--QLEPMAAGAAP 326
Query: 719 SAG--------IALRSLFCGSPPPEAASEKLESC----EKRKLKRVRISLASDADLEGEM 766
S G + RS PPP AS C + +KL++ S + G
Sbjct: 327 SPGPGPGPRESVTPRSTARLGPPPSHASADATRCLPCPDSQKLEK---ECQSSEESMGSN 383
Query: 767 SPEEILEWEEQQLDEP 782
S ILE +E+ + P
Sbjct: 384 SMRSILEEDEEDEEPP 399
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 34.3 bits (77), Expect = 0.53
Identities = 33/135 (24%), Positives = 46/135 (34%), Gaps = 7/135 (5%)
Query: 652 RRATQTSPLSDQEGPPTPEASVCFQVN----TEDSAFPAARGETHKPLKPALKRGPSVTR 707
R+A+ + Q GPP + N T A P + G +PLKP P+
Sbjct: 1701 RKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEG---RPLKPGQYVKPNFRL 1757
Query: 708 NLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMS 767
E+P A +SL G P + R R + ADL
Sbjct: 1758 TEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASG 1817
Query: 768 PEEILEWEEQQLDEP 782
PE + Q+L P
Sbjct: 1818 PEACKQESPQKLGAP 1832
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 34.3 bits (77), Expect = 0.53
Identities = 39/180 (21%), Positives = 67/180 (37%), Gaps = 8/180 (4%)
Query: 634 ALLGAQLSPARRRQHMQER-RATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETH 692
+L G+ P ++ Q R R+ + P + PP S + S P+ + +
Sbjct: 778 SLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSS 837
Query: 693 KPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASE--KLESCEKRKLK 750
P +K G + SP + +S RS F SP PE S SC
Sbjct: 838 SSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPP 897
Query: 751 RVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDC-KIDPAPFQLVERTSLHKTHTI 809
RV+ S SP+ + + + P S P+P ++ RT+ ++ ++
Sbjct: 898 RVKSSTPPRQSPSRSSSPQP----KVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSV 953
>gi|222080092 WD repeat domain 91 [Homo sapiens]
Length = 747
Score = 33.5 bits (75), Expect = 0.91
Identities = 46/192 (23%), Positives = 77/192 (40%), Gaps = 27/192 (14%)
Query: 620 SMILLGSIERSQVVALLGAQLSPARRRQHMQE---RRATQTSPLSDQEGPPTPEASVCFQ 676
+M LG E + V + A LS + R + + S LS +GPP P++S
Sbjct: 233 NMDRLGDSELAMVCSQRNASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQPQSS---- 288
Query: 677 VNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTG-------SAESAGIALRSLF- 728
+ +F +G K K G S+ L +G + G + LF
Sbjct: 289 --AKKESF-GGQGTKGKDPTSGAKDGKSLLSGLATGESGWSQHRQRRLQDHGKERKELFS 345
Query: 729 -----CGSPPPEAASEKLESCEKRKLKRVR-ISLASDADLE-GEMSPEE--ILEWEEQQL 779
C PEA+ + E C + + V ++ AS A E G + PE+ I+ +E+
Sbjct: 346 TTTSQCAEKKPEASGPEAEPCPELHTEPVEPLTRASSAGPEGGGVRPEQPFIVLGQEEYG 405
Query: 780 DEPVNFSDCKID 791
+ + C++D
Sbjct: 406 EHHSSIMHCRVD 417
>gi|113421234 PREDICTED: similar to NG5 protein [Homo sapiens]
Length = 288
Score = 33.1 bits (74), Expect = 1.2
Identities = 30/85 (35%), Positives = 37/85 (43%), Gaps = 16/85 (18%)
Query: 661 SDQEG---PPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNL------GE 711
SD +G P TPE + A PAA + P +PAL + P R L GE
Sbjct: 56 SDTKGGGSPATPE-------DPRSPAKPAAPEDPQMPAQPALPQLPRRPRTLDEDGAAGE 108
Query: 712 SPTGSAESAGIALRSLFCGSPPPEA 736
+ S +AG A F G PPP A
Sbjct: 109 AGPVSKAAAGGAPHIGFVGEPPPYA 133
>gi|113420954 PREDICTED: similar to NG5 protein [Homo sapiens]
Length = 288
Score = 33.1 bits (74), Expect = 1.2
Identities = 30/85 (35%), Positives = 37/85 (43%), Gaps = 16/85 (18%)
Query: 661 SDQEG---PPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNL------GE 711
SD +G P TPE + A PAA + P +PAL + P R L GE
Sbjct: 56 SDTKGGGSPATPE-------DPRSPAKPAAPEDPQMPAQPALPQLPRRPRTLDEDGAAGE 108
Query: 712 SPTGSAESAGIALRSLFCGSPPPEA 736
+ S +AG A F G PPP A
Sbjct: 109 AGPVSKAAAGGAPHIGFVGEPPPYA 133
>gi|164607124 Fanconi anemia, complementation group I isoform 1
[Homo sapiens]
Length = 1328
Score = 32.7 bits (73), Expect = 1.6
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 4/64 (6%)
Query: 708 NLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMS 767
NL ++ + AG LR++F GSP SE+ + +RK+ I L DL+ E++
Sbjct: 31 NLLQNQAVKGKVAGALLRAIFKGSP----CSEEAGTLRRRKIYTCCIQLVESGDLQKEIA 86
Query: 768 PEEI 771
E I
Sbjct: 87 SEII 90
>gi|82830440 Fanconi anemia, complementation group I isoform 2 [Homo
sapiens]
Length = 1268
Score = 32.7 bits (73), Expect = 1.6
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 4/64 (6%)
Query: 708 NLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMS 767
NL ++ + AG LR++F GSP SE+ + +RK+ I L DL+ E++
Sbjct: 31 NLLQNQAVKGKVAGALLRAIFKGSP----CSEEAGTLRRRKIYTCCIQLVESGDLQKEIA 86
Query: 768 PEEI 771
E I
Sbjct: 87 SEII 90
>gi|118498345 AT-binding transcription factor 1 [Homo sapiens]
Length = 3703
Score = 32.7 bits (73), Expect = 1.6
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 2/104 (1%)
Query: 624 LGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSA 683
L S +Q +G Q P +++Q Q+ + Q P + PPTP+ + Q +D
Sbjct: 3178 LSSPTPAQATMAMGPQ-QPPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKD 3236
Query: 684 FPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSL 727
+ E K K + P + GE+PT +A + L ++
Sbjct: 3237 SEKVK-EKEKAHKGKGEPLPVPKKEKGEAPTATAATISAPLPTM 3279
>gi|26051262 potassium voltage-gated channel KQT-like protein 2
isoform b [Homo sapiens]
Length = 854
Score = 32.3 bits (72), Expect = 2.0
Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 5/79 (6%)
Query: 652 RRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHK----PLKPALKRGPSVTR 707
R S L+ ++ PP PE S +V+ +D F + RG K P ++R PS +
Sbjct: 395 RNLKSKSGLAFRKDPP-PEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQ 453
Query: 708 NLGESPTGSAESAGIALRS 726
+L +SP+ +S RS
Sbjct: 454 SLEDSPSKVPKSWSFGDRS 472
>gi|26051260 potassium voltage-gated channel KQT-like protein 2
isoform c [Homo sapiens]
Length = 844
Score = 32.3 bits (72), Expect = 2.0
Identities = 24/79 (30%), Positives = 38/79 (48%), Gaps = 5/79 (6%)
Query: 652 RRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHK----PLKPALKRGPSVTR 707
R S L+ ++ PP PE S +V+ +D F + RG K P ++R PS +
Sbjct: 385 RNLKSKSGLAFRKDPP-PEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQ 443
Query: 708 NLGESPTGSAESAGIALRS 726
+L +SP+ +S RS
Sbjct: 444 SLEDSPSKVPKSWSFGDRS 462
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,775,039
Number of Sequences: 37866
Number of extensions: 1602324
Number of successful extensions: 4711
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 4593
Number of HSP's gapped (non-prelim): 110
length of query: 898
length of database: 18,247,518
effective HSP length: 111
effective length of query: 787
effective length of database: 14,044,392
effective search space: 11052936504
effective search space used: 11052936504
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.