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Search of human proteins with 155969701
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|155969701 espin-like [Homo sapiens]
(1005 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155969701 espin-like [Homo sapiens] 2063 0.0
gi|110431370 espin [Homo sapiens] 377 e-104
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 135 2e-31
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 126 1e-28
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 124 4e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 124 4e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 124 4e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 124 4e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 124 4e-28
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 124 6e-28
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 123 1e-27
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 123 1e-27
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 123 1e-27
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 120 5e-27
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 117 5e-26
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 114 5e-25
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 114 6e-25
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 113 8e-25
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 112 2e-24
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 112 2e-24
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 109 1e-23
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 107 7e-23
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 105 2e-22
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 105 2e-22
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 103 6e-22
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 103 6e-22
gi|34304381 inversin isoform a [Homo sapiens] 102 1e-21
gi|34304379 inversin isoform b [Homo sapiens] 102 1e-21
gi|24308163 fem-1 homolog a [Homo sapiens] 102 2e-21
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 101 4e-21
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 2063 bits (5344), Expect = 0.0
Identities = 1005/1005 (100%), Positives = 1005/1005 (100%)
Query: 1 MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ
Sbjct: 1 MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV
Sbjct: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ
Sbjct: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA
Sbjct: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
Query: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLR 300
TALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLR
Sbjct: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLR 300
Query: 301 DEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGRRGG 360
DEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGRRGG
Sbjct: 301 DEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGRRGG 360
Query: 361 PGPGNPSPMSLSPAWPGHPDQPLPREQMTSPAPPRIITSATADPEGTETALAGDTSDGLA 420
PGPGNPSPMSLSPAWPGHPDQPLPREQMTSPAPPRIITSATADPEGTETALAGDTSDGLA
Sbjct: 361 PGPGNPSPMSLSPAWPGHPDQPLPREQMTSPAPPRIITSATADPEGTETALAGDTSDGLA 420
Query: 421 ALQLDGLPSGDIDGLVPTRDERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPT 480
ALQLDGLPSGDIDGLVPTRDERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPT
Sbjct: 421 ALQLDGLPSGDIDGLVPTRDERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPT 480
Query: 481 EQAAWRYSQTHQAILGPFGELLTEDDLVYLEKQIADLQLRRRCQEYESELGRLAAELQAL 540
EQAAWRYSQTHQAILGPFGELLTEDDLVYLEKQIADLQLRRRCQEYESELGRLAAELQAL
Sbjct: 481 EQAAWRYSQTHQAILGPFGELLTEDDLVYLEKQIADLQLRRRCQEYESELGRLAAELQAL 540
Query: 541 LPEPLVSITVNSHFLPRAPGLEVEEASIPAAEPAGSAEASEVAPGVQPLPFWCSHISRLV 600
LPEPLVSITVNSHFLPRAPGLEVEEASIPAAEPAGSAEASEVAPGVQPLPFWCSHISRLV
Sbjct: 541 LPEPLVSITVNSHFLPRAPGLEVEEASIPAAEPAGSAEASEVAPGVQPLPFWCSHISRLV 600
Query: 601 RSLSLLLKGVHGLVQGDEKPSTRPLQDTCREASASPPRSEAQRQIQEWGVSVRTLRGNFE 660
RSLSLLLKGVHGLVQGDEKPSTRPLQDTCREASASPPRSEAQRQIQEWGVSVRTLRGNFE
Sbjct: 601 RSLSLLLKGVHGLVQGDEKPSTRPLQDTCREASASPPRSEAQRQIQEWGVSVRTLRGNFE 660
Query: 661 SASGPLCGFNPGPCEPGAQHRQCLSGCWPALPKPRSGLASGEPRPGDTEEASDSGISCEE 720
SASGPLCGFNPGPCEPGAQHRQCLSGCWPALPKPRSGLASGEPRPGDTEEASDSGISCEE
Sbjct: 661 SASGPLCGFNPGPCEPGAQHRQCLSGCWPALPKPRSGLASGEPRPGDTEEASDSGISCEE 720
Query: 721 VPSEAGAAAGPDLASLRKERIIMLFLSHWRRSAYTPALKTVACRTLGARHAGLRGQEAAR 780
VPSEAGAAAGPDLASLRKERIIMLFLSHWRRSAYTPALKTVACRTLGARHAGLRGQEAAR
Sbjct: 721 VPSEAGAAAGPDLASLRKERIIMLFLSHWRRSAYTPALKTVACRTLGARHAGLRGQEAAR 780
Query: 781 SPGPPSPPSEGPRLGHLWQQRSTITHLLGNWKAIMAHVPARQLRRLSRQPRGALSPEQFL 840
SPGPPSPPSEGPRLGHLWQQRSTITHLLGNWKAIMAHVPARQLRRLSRQPRGALSPEQFL
Sbjct: 781 SPGPPSPPSEGPRLGHLWQQRSTITHLLGNWKAIMAHVPARQLRRLSRQPRGALSPEQFL 840
Query: 841 PHVDGAPVPYSSLSLDLFMLGYFQLLECDLPAEERKLRHLLCFEVFEHLGTHGWEAVRAF 900
PHVDGAPVPYSSLSLDLFMLGYFQLLECDLPAEERKLRHLLCFEVFEHLGTHGWEAVRAF
Sbjct: 841 PHVDGAPVPYSSLSLDLFMLGYFQLLECDLPAEERKLRHLLCFEVFEHLGTHGWEAVRAF 900
Query: 901 HKAVTDEVAAGRRAWTDGFEDIKARFFGSSQRPAWDTEPGRKSGLTLLGPLPHAAVPCSG 960
HKAVTDEVAAGRRAWTDGFEDIKARFFGSSQRPAWDTEPGRKSGLTLLGPLPHAAVPCSG
Sbjct: 901 HKAVTDEVAAGRRAWTDGFEDIKARFFGSSQRPAWDTEPGRKSGLTLLGPLPHAAVPCSG 960
Query: 961 PEPTAQRLGSRSQQGSFNGEDICGYINRSFAFWKEKEAEMFNFGE 1005
PEPTAQRLGSRSQQGSFNGEDICGYINRSFAFWKEKEAEMFNFGE
Sbjct: 961 PEPTAQRLGSRSQQGSFNGEDICGYINRSFAFWKEKEAEMFNFGE 1005
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 377 bits (967), Expect = e-104
Identities = 185/327 (56%), Positives = 233/327 (71%), Gaps = 1/327 (0%)
Query: 1 MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
M ++AL AA+ G++ L L AG LGP + D L A VHHA RAG L C++FLV+ A
Sbjct: 1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAA 60
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
LP RA NGATPAHDA+ATG LA L WL+ +GGC +QD+D SG + LHLAARFGHP +V
Sbjct: 61 LPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVV 120
Query: 121 EWLLHEGHS-ATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
WLLH G T T GA P+H+AA GD L+LL + VN +T++GA+PLYLAC
Sbjct: 121 NWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLAC 180
Query: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
QEGHL + Q+LV++CGAD H RA DGM+ LHAAA GH ++VWLV+ TD+ L+ +D +G
Sbjct: 181 QEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDG 240
Query: 240 ATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSL 299
ATA+HFAA GHT +L LLL G I D WGGTPLHDAAENG++ECCQ LV + + +
Sbjct: 241 ATAMHFAASRGHTKVLSWLLLHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDV 300
Query: 300 RDEDGYTAADLAEYHGHRDCAQYLREV 326
RD DGYTAADL++++GH C +YLR V
Sbjct: 301 RDRDGYTAADLSDFNGHSHCTRYLRTV 327
Score = 97.8 bits (242), Expect = 4e-20
Identities = 100/382 (26%), Positives = 154/382 (40%), Gaps = 45/382 (11%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA+ G + LL G P +GA +H+A G ++ LV+ N +
Sbjct: 110 LAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQT 169
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH-E 126
NGATP + A G L +LV+E G + G++PLH AA+ GH ++ WL+
Sbjct: 170 KNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCT 229
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
S + + ++GA +H AA G L L HG ++ G +PL+ A + G L
Sbjct: 230 DVSLSEQDKDGATAMHFAASRGHTKVLSWLLL-HGGEISADLWGG-TPLHDAAENGELEC 287
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIG----LTARDNEGATA 242
Q LV + GA++ +R DG +A + GH +L T ++ + +RD
Sbjct: 288 CQILVVN-GAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSRDPSAELE 346
Query: 243 LHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDE 302
G +P + P+ D T + + C + SH
Sbjct: 347 AKQPDSGMSSP---NTTVSVQPLNFDLSSPT-----STLSNYDSCSS--SHSSIKGQHPP 396
Query: 303 DGYTAADLAEYHGHRDCAQ-----YLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGR 357
G ++A A+ + D + +P P PPPP FPPPP
Sbjct: 397 CGLSSARAADIQSYMDMLNPELGLPRGTIGKPTP---PPPPPSFPPPP------------ 441
Query: 358 RGGPGPGNPSPMSLSPAWPGHP 379
P PG P P PG+P
Sbjct: 442 ---PPPGTQLP----PPPPGYP 456
Score = 69.3 bits (168), Expect = 2e-11
Identities = 67/229 (29%), Positives = 84/229 (36%), Gaps = 60/229 (26%)
Query: 307 AADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDG-----RRGGP 361
AA L H CA A P PPPPP PPPPL S GP
Sbjct: 573 AALLPGNHVPNGCA------ADPKASRELPPPPPPPPPPLPEAASSPPPAPPLPLESAGP 626
Query: 362 GPGN------------------------------------PSPMS--LSPAWPG------ 377
G G P+P S L+ + G
Sbjct: 627 GCGQRRSSSSTGSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPAF 686
Query: 378 HPDQPLPREQMTSPAPPRIITSATADPEGTETALAGDTSDGLAALQLDGLPSGDIDGLVP 437
PD PLP SPA + S T G + L G G+ D++ L+P
Sbjct: 687 QPDSPLPS---VSPALSPV-RSPTPPAAGFQPLLNGSLVPVPPTTPAPGVQL-DVEALIP 741
Query: 438 TRDERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPTEQAAWR 486
T DE+G+PIPEWKRQVMVRK+Q ++ E ++ + AWR
Sbjct: 742 THDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKEEEEEARLASMPAWR 790
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 135 bits (340), Expect = 2e-31
Identities = 110/356 (30%), Positives = 163/356 (45%), Gaps = 39/356 (10%)
Query: 1 MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
++K++ + A GD + L ++L+ + + GA L+H A AG +C K+L+
Sbjct: 405 VQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNA 462
Query: 61 LPGNQRAHNGATPAHDAA----------------ATGSLAELCW---------------- 88
P N G+TP H A + + E W
Sbjct: 463 NP-NLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTR 521
Query: 89 LVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSG 148
L+ E + + D G +P+H+A + G +V LL G +L+ ++ PLH+AA G
Sbjct: 522 LLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQG 581
Query: 149 DLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSA 208
L +KLL G SVN +T G +PL+LA Q GH +A+ L+ C +DV++ +L +
Sbjct: 582 HLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLC-SDVNVCSLLAQTP 640
Query: 209 LHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPIL-R 267
LH AA GH S L+ G A ++G TALH AAR GH + L+ +L R
Sbjct: 641 LHVAAETGHTS-TARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
Query: 268 DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
T LH AA +G E + LVS V L DE G +A LA H + L
Sbjct: 700 GPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETL 754
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 126 bits (316), Expect = 1e-28
Identities = 97/318 (30%), Positives = 157/318 (49%), Gaps = 9/318 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQLPGNQR 66
VAA G V + +L+ GA P T+ G +H A R+G + V++LVQ AQ+ +
Sbjct: 439 VAAFMGHVNIVSQLMHHGA-SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA--K 495
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
A + TP H +A G A++ + + G SG +PLHL+AR GH + +LL
Sbjct: 496 AKDDQTPLHISARLGK-ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G S ++ T++G PLH AA G L LL +S + +SG +PL++A + +
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLL-LQKSASPDAAGKSGLTPLHVAAHYDNQKV 613
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
A L+ D GA H A +G + LH AA + + L+ + A +G ++H A
Sbjct: 614 A-LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEY-GADANAVTRQGIASVHLA 671
Query: 247 ARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
A+ GH ++ LL + L + G TPLH AA+ ++ + LV+ + + GY
Sbjct: 672 AQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731
Query: 306 TAADLAEYHGHRDCAQYL 323
T + ++G+ +L
Sbjct: 732 TPLHVGCHYGNIKIVNFL 749
Score = 117 bits (293), Expect = 5e-26
Identities = 94/349 (26%), Positives = 151/349 (43%), Gaps = 38/349 (10%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA+ D LL+ + G +H A G+++ L+ RA + A
Sbjct: 208 IAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAV-DFTA 265
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
N TP H A+ G+ A + L+ + G + + G++PLH AR GH +VE LL
Sbjct: 266 RNDITPLHVASKRGN-ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKL---------------LTAAH------------ 160
+T+ G PLH A L C++L LTA H
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
Query: 161 -----GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
++ N + +G +PL++AC++ + + + L+K GA + G++ +H AA
Sbjct: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH-GASIQAVTESGLTPIHVAAFM 443
Query: 216 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTP 274
GH ++V L+ + G TALH AAR G ++ L+ G + + TP
Sbjct: 444 GHVNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
Query: 275 LHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
LH +A G+ + Q L+ P+ GYT L+ GH D A +L
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Score = 117 bits (292), Expect = 7e-26
Identities = 89/317 (28%), Positives = 149/317 (47%), Gaps = 33/317 (10%)
Query: 36 GAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGC 95
G +H A++ GH++ V L+QR + + G T H A+ G AE+ ++ G
Sbjct: 74 GLNALHLASKEGHVEVVSELLQR-EANVDAATKKGNTALHIASLAGQ-AEVVKVLVTNGA 131
Query: 96 GLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLH------------- 142
+ Q +G +PL++AA+ H +V++LL G S +L T +G PL
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSL 191
Query: 143 ---------------HAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
H A D T L + ++ + ++SG +PL++A G++++A
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
L+ A V A + ++ LH A+ RG+ ++V L+ + A+ +G T LH A
Sbjct: 252 TLLLNRAAA-VDFTARNDITPLHVASKRGNANMVKLLLD-RGAKIDAKTRDGLTPLHCGA 309
Query: 248 RGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
R GH +++ LL PIL + G +PLH A + + C Q L+ H+V D T
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLT 369
Query: 307 AADLAEYHGHRDCAQYL 323
A +A + GH A+ L
Sbjct: 370 ALHVAAHCGHYKVAKVL 386
Score = 98.6 bits (244), Expect = 3e-20
Identities = 83/310 (26%), Positives = 139/310 (44%), Gaps = 11/310 (3%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA++ + ++ LL+ GA T+ G + A + GH V L++ N
Sbjct: 146 MAAQENHLEVVKFLLDNGASQSLATED-GFTPLAVALQQGHDQVVSLLLE------NDTK 198
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
PA AA + L+ + + SG +PLH+AA +G+ + LL+
Sbjct: 199 GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ R PLH A+ G+ +KLL G+ ++ +TR G +PL+ + GH +
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLL-LDRGAKIDAKTRDGLTPLHCGARSGHEQVV 317
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+ L+ D A + + +G+S LH A H + V L+ ++ + N+ TALH AA
Sbjct: 318 EMLL-DRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH-NVPVDDVTNDYLTALHVAA 375
Query: 248 RGGHTPILDRLL-LMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
GH + LL P + G TPLH A + +++ + L+ H E G T
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLT 435
Query: 307 AADLAEYHGH 316
+A + GH
Sbjct: 436 PIHVAAFMGH 445
Score = 92.8 bits (229), Expect = 1e-18
Identities = 78/286 (27%), Positives = 128/286 (44%), Gaps = 38/286 (13%)
Query: 77 AAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
AA G L + ++ G + + +G++ LHLA++ GH +V LL + T++
Sbjct: 48 AARAGHLEKALDYIKNG-VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK 106
Query: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196
G LH A+++G +K+L +G++VN ++++G +PLY+A QE HL + +FL+ D GA
Sbjct: 107 GNTALHIASLAGQAEVVKVLVT-NGANVNAQSQNGFTPLYMAAQENHLEVVKFLL-DNGA 164
Query: 197 DVHLRALDGMSALHAAAARGHYSLVVWL--------VTFTDIGLTARDNE---------- 238
L DG + L A +GH +V L V + + AR ++
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 239 ----------GATALHFAARGGH----TPILDRLLLMGTPILRDSWGGTPLHDAAENGQM 284
G T LH AA G+ T +L+R + D TPLH A++ G
Sbjct: 225 DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI---TPLHVASKRGNA 281
Query: 285 ECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
+ L+ + DG T GH + L + A P+
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Score = 75.5 bits (184), Expect = 2e-13
Identities = 61/226 (26%), Positives = 100/226 (44%), Gaps = 38/226 (16%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AAK + LLE GA +T G VH A + GH+D V L+ R
Sbjct: 637 IAAKKNQMDIATTLLEYGADANAVTRQ-GIASVHLAAQEGHVDMVSLLLGR--------- 686
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ + SG++PLHLAA+ + E L+++G
Sbjct: 687 --------------------------NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+T+ G PLH G++ + L H + VN +T++G +PL+ A Q+GH H+
Sbjct: 721 AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHII 779
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLT 233
L+++ A + ++G +AL A G+ S+V L T+ +T
Sbjct: 780 NVLLQN-NASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT 824
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 124 bits (311), Expect = 4e-28
Identities = 97/319 (30%), Positives = 154/319 (48%), Gaps = 7/319 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA++ D T LL+ P + G +H A +L+ + L+ R N
Sbjct: 212 IAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTP 269
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H A+ G++ + L+ + G ++ + ++PLH AAR GH + E LL G
Sbjct: 270 QNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+T+ G P+H AA L C++LL + + ++ T +PL++A GH +A
Sbjct: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLL-LQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+ L+ D GA + RAL+G + LH A + H V+ L+ T + A G T LH A+
Sbjct: 388 KVLL-DKGAKPNSRALNGFTPLHIACKKNHVR-VMELLLKTGASIDAVTESGLTPLHVAS 445
Query: 248 RGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
GH PI+ LL G +P + + TPLH AA G E + L+ + + + +D T
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 505
Query: 307 AADLAEYHGHRDCAQYLRE 325
A GH + + L E
Sbjct: 506 PLHCAARIGHTNMVKLLLE 524
Score = 123 bits (309), Expect = 8e-28
Identities = 99/349 (28%), Positives = 158/349 (45%), Gaps = 38/349 (10%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VA+ G + ++ LL+ GA P +++ +H A RAGH + K+L+Q + N +A
Sbjct: 443 VASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKA 500
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ TP H AA G + L+ E +G +PLH+AAR GH V LL +
Sbjct: 501 KDDQTPLHCAARIGH-TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 559
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLL-------------------TAAH-------- 160
S T++G PLH AA G + +LL A H
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
Query: 161 -----GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
G S + +G +PL++A ++ + +A+ L++ G + ++ G++ LH AA
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQE 678
Query: 216 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTP 274
GH +V L++ G + G T LH A+ GH P+ D L+ G + G TP
Sbjct: 679 GHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 737
Query: 275 LHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
LH A+ G ++ + L+ H D + + + GY+ A GH D L
Sbjct: 738 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Score = 112 bits (281), Expect = 1e-24
Identities = 94/320 (29%), Positives = 151/320 (47%), Gaps = 9/320 (2%)
Query: 8 VAAKDGDVATLERLLEAGA-LGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
+A++ G+V + LL+ GA + D L +H A R GH+ + L+ P +
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTP--LHCAARNGHVRISEILLDHGA-PIQAK 334
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
NG +P H AA G + L+ + + D ++PLH+AA GH + + LL +
Sbjct: 335 TKNGLSPIH-MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G G PLH A + ++LL G+S++ T SG +PL++A GHL +
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPI 452
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+ L++ GA ++ + + LH AA GH + +L+ + A+ + T LH A
Sbjct: 453 VKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-NKAKVNAKAKDDQTPLHCA 510
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AR GHT ++ LL P L + G TPLH AA G +E L+ + + G+
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 570
Query: 306 TAADLAEYHGHRDCAQYLRE 325
T +A +G A+ L E
Sbjct: 571 TPLHVAAKYGKVRVAELLLE 590
Score = 112 bits (281), Expect = 1e-24
Identities = 88/251 (35%), Positives = 122/251 (48%), Gaps = 6/251 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAAK G V E LLE A P G +H A +LD VK L+ R P + A
Sbjct: 575 VAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HSPA 632
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H AA + L++ GG + GV+PLHLAA+ GH +V LL +
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ L + G PLH A G + +L HG V+ TR G +PL++A G++ L
Sbjct: 692 ANGNLGNKSGLTPLHLVAQEGHVPVADVL-IKHGVMVDATTRMGYTPLHVASHYGNIKLV 750
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+FL++ ADV+ + G S LH AA +GH +V L+ ++G T L A
Sbjct: 751 KFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK-NGASPNEVSSDGTTPLAIAK 808
Query: 248 RGGHTPILDRL 258
R G+ + D L
Sbjct: 809 RLGYISVTDVL 819
Score = 99.0 bits (245), Expect = 2e-20
Identities = 75/249 (30%), Positives = 126/249 (50%), Gaps = 9/249 (3%)
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
+ AT AA +G+L + +R G + + +G++ LHLA++ GH +V LLH+
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQ 188
T++G LH AA++G ++ L +G++VN +++ G +PLY+A QE HL + +
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLEVVK 161
Query: 189 FLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAAR 248
FL+++ GA+ ++ DG + L A +GH ++V L+ + G ALH AAR
Sbjct: 162 FLLEN-GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHIAAR 215
Query: 249 GGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTA 307
T LL P + G TPLH AA + Q L++ + ++G T
Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITP 275
Query: 308 ADLAEYHGH 316
+A G+
Sbjct: 276 LHIASRRGN 284
Score = 68.2 bits (165), Expect = 4e-11
Identities = 48/163 (29%), Positives = 86/163 (52%), Gaps = 4/163 (2%)
Query: 163 SVNRRTRSGASPLYL-ACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV 221
S +R+ ++ A+ +L A + G+L A +++ G D++ +G++ LH A+ GH +V
Sbjct: 36 SRDRKKKADAATSFLRAARSGNLDKALDHLRN-GVDINTCNQNGLNGLHLASKEGHVKMV 94
Query: 222 VWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAE 280
V L+ +I L +G TALH AA G ++ L+ G + S G TPL+ AA+
Sbjct: 95 VELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 153
Query: 281 NGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
+E + L+ + + ++ EDG+T +A GH + +L
Sbjct: 154 ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 230 IGLTARDNEGATALHFAARGGHTPILDRLL----LMGTPILRDSWGGTPLHDAAENGQME 285
+ + + G LH A++ GH ++ LL ++ T + G T LH AA GQ E
Sbjct: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK---GNTALHIAALAGQDE 125
Query: 286 CCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ LV++ + + + + G+T +A H + ++L E
Sbjct: 126 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 124 bits (311), Expect = 4e-28
Identities = 97/319 (30%), Positives = 154/319 (48%), Gaps = 7/319 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA++ D T LL+ P + G +H A +L+ + L+ R N
Sbjct: 179 IAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTP 236
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H A+ G++ + L+ + G ++ + ++PLH AAR GH + E LL G
Sbjct: 237 QNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+T+ G P+H AA L C++LL + + ++ T +PL++A GH +A
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLL-LQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+ L+ D GA + RAL+G + LH A + H V+ L+ T + A G T LH A+
Sbjct: 355 KVLL-DKGAKPNSRALNGFTPLHIACKKNHVR-VMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 248 RGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
GH PI+ LL G +P + + TPLH AA G E + L+ + + + +D T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 307 AADLAEYHGHRDCAQYLRE 325
A GH + + L E
Sbjct: 473 PLHCAARIGHTNMVKLLLE 491
Score = 123 bits (309), Expect = 8e-28
Identities = 99/349 (28%), Positives = 158/349 (45%), Gaps = 38/349 (10%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VA+ G + ++ LL+ GA P +++ +H A RAGH + K+L+Q + N +A
Sbjct: 410 VASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKA 467
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ TP H AA G + L+ E +G +PLH+AAR GH V LL +
Sbjct: 468 KDDQTPLHCAARIGH-TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLL-------------------TAAH-------- 160
S T++G PLH AA G + +LL A H
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 161 -----GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
G S + +G +PL++A ++ + +A+ L++ G + ++ G++ LH AA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQE 645
Query: 216 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTP 274
GH +V L++ G + G T LH A+ GH P+ D L+ G + G TP
Sbjct: 646 GHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 275 LHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
LH A+ G ++ + L+ H D + + + GY+ A GH D L
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 112 bits (281), Expect = 1e-24
Identities = 94/320 (29%), Positives = 151/320 (47%), Gaps = 9/320 (2%)
Query: 8 VAAKDGDVATLERLLEAGA-LGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
+A++ G+V + LL+ GA + D L +H A R GH+ + L+ P +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP--LHCAARNGHVRISEILLDHGA-PIQAK 301
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
NG +P H AA G + L+ + + D ++PLH+AA GH + + LL +
Sbjct: 302 TKNGLSPIH-MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G G PLH A + ++LL G+S++ T SG +PL++A GHL +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPI 419
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+ L++ GA ++ + + LH AA GH + +L+ + A+ + T LH A
Sbjct: 420 VKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-NKAKVNAKAKDDQTPLHCA 477
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AR GHT ++ LL P L + G TPLH AA G +E L+ + + G+
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 306 TAADLAEYHGHRDCAQYLRE 325
T +A +G A+ L E
Sbjct: 538 TPLHVAAKYGKVRVAELLLE 557
Score = 112 bits (281), Expect = 1e-24
Identities = 88/251 (35%), Positives = 122/251 (48%), Gaps = 6/251 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAAK G V E LLE A P G +H A +LD VK L+ R P + A
Sbjct: 542 VAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HSPA 599
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H AA + L++ GG + GV+PLHLAA+ GH +V LL +
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ L + G PLH A G + +L HG V+ TR G +PL++A G++ L
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVL-IKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+FL++ ADV+ + G S LH AA +GH +V L+ ++G T L A
Sbjct: 718 KFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK-NGASPNEVSSDGTTPLAIAK 775
Query: 248 RGGHTPILDRL 258
R G+ + D L
Sbjct: 776 RLGYISVTDVL 786
Score = 99.8 bits (247), Expect = 1e-20
Identities = 76/252 (30%), Positives = 127/252 (50%), Gaps = 9/252 (3%)
Query: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
R + AT AA +G+L + +R G + + +G++ LHLA++ GH +V LLH
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
+ T++G LH AA++G ++ L +G++VN +++ G +PLY+A QE HL
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 186 LAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHF 245
+ +FL+++ GA+ ++ DG + L A +GH ++V L+ + G ALH
Sbjct: 126 VVKFLLEN-GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHI 179
Query: 246 AARGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDG 304
AAR T LL P + G TPLH AA + Q L++ + ++G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 305 YTAADLAEYHGH 316
T +A G+
Sbjct: 240 ITPLHIASRRGN 251
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/162 (29%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 163 SVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVV 222
SV R A+ A + G+L A +++ G D++ +G++ LH A+ GH +VV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRN-GVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 223 WLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAEN 281
L+ +I L +G TALH AA G ++ L+ G + S G TPL+ AA+
Sbjct: 63 ELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 282 GQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
+E + L+ + + ++ EDG+T +A GH + +L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 230 IGLTARDNEGATALHFAARGGHTPILDRLL----LMGTPILRDSWGGTPLHDAAENGQME 285
+ + + G LH A++ GH ++ LL ++ T + G T LH AA GQ E
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK---GNTALHIAALAGQDE 92
Query: 286 CCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ LV++ + + + + G+T +A H + ++L E
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 124 bits (311), Expect = 4e-28
Identities = 97/319 (30%), Positives = 154/319 (48%), Gaps = 7/319 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA++ D T LL+ P + G +H A +L+ + L+ R N
Sbjct: 179 IAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTP 236
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H A+ G++ + L+ + G ++ + ++PLH AAR GH + E LL G
Sbjct: 237 QNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+T+ G P+H AA L C++LL + + ++ T +PL++A GH +A
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLL-LQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+ L+ D GA + RAL+G + LH A + H V+ L+ T + A G T LH A+
Sbjct: 355 KVLL-DKGAKPNSRALNGFTPLHIACKKNHVR-VMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 248 RGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
GH PI+ LL G +P + + TPLH AA G E + L+ + + + +D T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 307 AADLAEYHGHRDCAQYLRE 325
A GH + + L E
Sbjct: 473 PLHCAARIGHTNMVKLLLE 491
Score = 123 bits (309), Expect = 8e-28
Identities = 99/349 (28%), Positives = 158/349 (45%), Gaps = 38/349 (10%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VA+ G + ++ LL+ GA P +++ +H A RAGH + K+L+Q + N +A
Sbjct: 410 VASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKA 467
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ TP H AA G + L+ E +G +PLH+AAR GH V LL +
Sbjct: 468 KDDQTPLHCAARIGH-TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLL-------------------TAAH-------- 160
S T++G PLH AA G + +LL A H
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 161 -----GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
G S + +G +PL++A ++ + +A+ L++ G + ++ G++ LH AA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQE 645
Query: 216 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTP 274
GH +V L++ G + G T LH A+ GH P+ D L+ G + G TP
Sbjct: 646 GHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 275 LHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
LH A+ G ++ + L+ H D + + + GY+ A GH D L
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 112 bits (281), Expect = 1e-24
Identities = 94/320 (29%), Positives = 151/320 (47%), Gaps = 9/320 (2%)
Query: 8 VAAKDGDVATLERLLEAGA-LGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
+A++ G+V + LL+ GA + D L +H A R GH+ + L+ P +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP--LHCAARNGHVRISEILLDHGA-PIQAK 301
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
NG +P H AA G + L+ + + D ++PLH+AA GH + + LL +
Sbjct: 302 TKNGLSPIH-MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G G PLH A + ++LL G+S++ T SG +PL++A GHL +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPI 419
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+ L++ GA ++ + + LH AA GH + +L+ + A+ + T LH A
Sbjct: 420 VKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-NKAKVNAKAKDDQTPLHCA 477
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AR GHT ++ LL P L + G TPLH AA G +E L+ + + G+
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 306 TAADLAEYHGHRDCAQYLRE 325
T +A +G A+ L E
Sbjct: 538 TPLHVAAKYGKVRVAELLLE 557
Score = 112 bits (281), Expect = 1e-24
Identities = 88/251 (35%), Positives = 122/251 (48%), Gaps = 6/251 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAAK G V E LLE A P G +H A +LD VK L+ R P + A
Sbjct: 542 VAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HSPA 599
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H AA + L++ GG + GV+PLHLAA+ GH +V LL +
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ L + G PLH A G + +L HG V+ TR G +PL++A G++ L
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVL-IKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+FL++ ADV+ + G S LH AA +GH +V L+ ++G T L A
Sbjct: 718 KFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK-NGASPNEVSSDGTTPLAIAK 775
Query: 248 RGGHTPILDRL 258
R G+ + D L
Sbjct: 776 RLGYISVTDVL 786
Score = 99.8 bits (247), Expect = 1e-20
Identities = 76/252 (30%), Positives = 127/252 (50%), Gaps = 9/252 (3%)
Query: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
R + AT AA +G+L + +R G + + +G++ LHLA++ GH +V LLH
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
+ T++G LH AA++G ++ L +G++VN +++ G +PLY+A QE HL
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 186 LAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHF 245
+ +FL+++ GA+ ++ DG + L A +GH ++V L+ + G ALH
Sbjct: 126 VVKFLLEN-GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHI 179
Query: 246 AARGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDG 304
AAR T LL P + G TPLH AA + Q L++ + ++G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 305 YTAADLAEYHGH 316
T +A G+
Sbjct: 240 ITPLHIASRRGN 251
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/162 (29%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 163 SVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVV 222
SV R A+ A + G+L A +++ G D++ +G++ LH A+ GH +VV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRN-GVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 223 WLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAEN 281
L+ +I L +G TALH AA G ++ L+ G + S G TPL+ AA+
Sbjct: 63 ELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 282 GQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
+E + L+ + + ++ EDG+T +A GH + +L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 230 IGLTARDNEGATALHFAARGGHTPILDRLL----LMGTPILRDSWGGTPLHDAAENGQME 285
+ + + G LH A++ GH ++ LL ++ T + G T LH AA GQ E
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK---GNTALHIAALAGQDE 92
Query: 286 CCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ LV++ + + + + G+T +A H + ++L E
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 124 bits (311), Expect = 4e-28
Identities = 97/319 (30%), Positives = 154/319 (48%), Gaps = 7/319 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA++ D T LL+ P + G +H A +L+ + L+ R N
Sbjct: 179 IAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTP 236
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H A+ G++ + L+ + G ++ + ++PLH AAR GH + E LL G
Sbjct: 237 QNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+T+ G P+H AA L C++LL + + ++ T +PL++A GH +A
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLL-LQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+ L+ D GA + RAL+G + LH A + H V+ L+ T + A G T LH A+
Sbjct: 355 KVLL-DKGAKPNSRALNGFTPLHIACKKNHVR-VMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 248 RGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
GH PI+ LL G +P + + TPLH AA G E + L+ + + + +D T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 307 AADLAEYHGHRDCAQYLRE 325
A GH + + L E
Sbjct: 473 PLHCAARIGHTNMVKLLLE 491
Score = 123 bits (309), Expect = 8e-28
Identities = 99/349 (28%), Positives = 158/349 (45%), Gaps = 38/349 (10%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VA+ G + ++ LL+ GA P +++ +H A RAGH + K+L+Q + N +A
Sbjct: 410 VASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKA 467
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ TP H AA G + L+ E +G +PLH+AAR GH V LL +
Sbjct: 468 KDDQTPLHCAARIGH-TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLL-------------------TAAH-------- 160
S T++G PLH AA G + +LL A H
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 161 -----GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
G S + +G +PL++A ++ + +A+ L++ G + ++ G++ LH AA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQE 645
Query: 216 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTP 274
GH +V L++ G + G T LH A+ GH P+ D L+ G + G TP
Sbjct: 646 GHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 275 LHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
LH A+ G ++ + L+ H D + + + GY+ A GH D L
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 112 bits (281), Expect = 1e-24
Identities = 94/320 (29%), Positives = 151/320 (47%), Gaps = 9/320 (2%)
Query: 8 VAAKDGDVATLERLLEAGA-LGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
+A++ G+V + LL+ GA + D L +H A R GH+ + L+ P +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP--LHCAARNGHVRISEILLDHGA-PIQAK 301
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
NG +P H AA G + L+ + + D ++PLH+AA GH + + LL +
Sbjct: 302 TKNGLSPIH-MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G G PLH A + ++LL G+S++ T SG +PL++A GHL +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPI 419
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+ L++ GA ++ + + LH AA GH + +L+ + A+ + T LH A
Sbjct: 420 VKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-NKAKVNAKAKDDQTPLHCA 477
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AR GHT ++ LL P L + G TPLH AA G +E L+ + + G+
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 306 TAADLAEYHGHRDCAQYLRE 325
T +A +G A+ L E
Sbjct: 538 TPLHVAAKYGKVRVAELLLE 557
Score = 112 bits (281), Expect = 1e-24
Identities = 88/251 (35%), Positives = 122/251 (48%), Gaps = 6/251 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAAK G V E LLE A P G +H A +LD VK L+ R P + A
Sbjct: 542 VAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HSPA 599
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H AA + L++ GG + GV+PLHLAA+ GH +V LL +
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ L + G PLH A G + +L HG V+ TR G +PL++A G++ L
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVL-IKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+FL++ ADV+ + G S LH AA +GH +V L+ ++G T L A
Sbjct: 718 KFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK-NGASPNEVSSDGTTPLAIAK 775
Query: 248 RGGHTPILDRL 258
R G+ + D L
Sbjct: 776 RLGYISVTDVL 786
Score = 99.8 bits (247), Expect = 1e-20
Identities = 76/252 (30%), Positives = 127/252 (50%), Gaps = 9/252 (3%)
Query: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
R + AT AA +G+L + +R G + + +G++ LHLA++ GH +V LLH
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
+ T++G LH AA++G ++ L +G++VN +++ G +PLY+A QE HL
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 186 LAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHF 245
+ +FL+++ GA+ ++ DG + L A +GH ++V L+ + G ALH
Sbjct: 126 VVKFLLEN-GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHI 179
Query: 246 AARGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDG 304
AAR T LL P + G TPLH AA + Q L++ + ++G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 305 YTAADLAEYHGH 316
T +A G+
Sbjct: 240 ITPLHIASRRGN 251
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/162 (29%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 163 SVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVV 222
SV R A+ A + G+L A +++ G D++ +G++ LH A+ GH +VV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRN-GVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 223 WLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAEN 281
L+ +I L +G TALH AA G ++ L+ G + S G TPL+ AA+
Sbjct: 63 ELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 282 GQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
+E + L+ + + ++ EDG+T +A GH + +L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 230 IGLTARDNEGATALHFAARGGHTPILDRLL----LMGTPILRDSWGGTPLHDAAENGQME 285
+ + + G LH A++ GH ++ LL ++ T + G T LH AA GQ E
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK---GNTALHIAALAGQDE 92
Query: 286 CCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ LV++ + + + + G+T +A H + ++L E
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 124 bits (311), Expect = 4e-28
Identities = 97/319 (30%), Positives = 154/319 (48%), Gaps = 7/319 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA++ D T LL+ P + G +H A +L+ + L+ R N
Sbjct: 179 IAARNDDTRTAAVLLQNDP-NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV-NFTP 236
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H A+ G++ + L+ + G ++ + ++PLH AAR GH + E LL G
Sbjct: 237 QNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+T+ G P+H AA L C++LL + + ++ T +PL++A GH +A
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLL-LQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+ L+ D GA + RAL+G + LH A + H V+ L+ T + A G T LH A+
Sbjct: 355 KVLL-DKGAKPNSRALNGFTPLHIACKKNHVR-VMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 248 RGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
GH PI+ LL G +P + + TPLH AA G E + L+ + + + +D T
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 307 AADLAEYHGHRDCAQYLRE 325
A GH + + L E
Sbjct: 473 PLHCAARIGHTNMVKLLLE 491
Score = 123 bits (309), Expect = 8e-28
Identities = 99/349 (28%), Positives = 158/349 (45%), Gaps = 38/349 (10%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VA+ G + ++ LL+ GA P +++ +H A RAGH + K+L+Q + N +A
Sbjct: 410 VASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAGHTEVAKYLLQN-KAKVNAKA 467
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ TP H AA G + L+ E +G +PLH+AAR GH V LL +
Sbjct: 468 KDDQTPLHCAARIGH-TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLL-------------------TAAH-------- 160
S T++G PLH AA G + +LL A H
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 161 -----GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAAR 215
G S + +G +PL++A ++ + +A+ L++ G + ++ G++ LH AA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ-YGGSANAESVQGVTPLHLAAQE 645
Query: 216 GHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTP 274
GH +V L++ G + G T LH A+ GH P+ D L+ G + G TP
Sbjct: 646 GHAEMVALLLSKQANG-NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 275 LHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
LH A+ G ++ + L+ H D + + + GY+ A GH D L
Sbjct: 705 LHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 112 bits (281), Expect = 1e-24
Identities = 94/320 (29%), Positives = 151/320 (47%), Gaps = 9/320 (2%)
Query: 8 VAAKDGDVATLERLLEAGA-LGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
+A++ G+V + LL+ GA + D L +H A R GH+ + L+ P +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTP--LHCAARNGHVRISEILLDHGA-PIQAK 301
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
NG +P H AA G + L+ + + D ++PLH+AA GH + + LL +
Sbjct: 302 TKNGLSPIH-MAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G G PLH A + ++LL G+S++ T SG +PL++A GHL +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPI 419
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+ L++ GA ++ + + LH AA GH + +L+ + A+ + T LH A
Sbjct: 420 VKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLLQ-NKAKVNAKAKDDQTPLHCA 477
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AR GHT ++ LL P L + G TPLH AA G +E L+ + + G+
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 306 TAADLAEYHGHRDCAQYLRE 325
T +A +G A+ L E
Sbjct: 538 TPLHVAAKYGKVRVAELLLE 557
Score = 112 bits (281), Expect = 1e-24
Identities = 88/251 (35%), Positives = 122/251 (48%), Gaps = 6/251 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAAK G V E LLE A P G +H A +LD VK L+ R P + A
Sbjct: 542 VAAKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HSPA 599
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
NG TP H AA + L++ GG + GV+PLHLAA+ GH +V LL +
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSA-NAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ L + G PLH A G + +L HG V+ TR G +PL++A G++ L
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVL-IKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
+FL++ ADV+ + G S LH AA +GH +V L+ ++G T L A
Sbjct: 718 KFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK-NGASPNEVSSDGTTPLAIAK 775
Query: 248 RGGHTPILDRL 258
R G+ + D L
Sbjct: 776 RLGYISVTDVL 786
Score = 99.8 bits (247), Expect = 1e-20
Identities = 76/252 (30%), Positives = 127/252 (50%), Gaps = 9/252 (3%)
Query: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
R + AT AA +G+L + +R G + + +G++ LHLA++ GH +V LLH
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNG-VDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
+ T++G LH AA++G ++ L +G++VN +++ G +PLY+A QE HL
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 186 LAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHF 245
+ +FL+++ GA+ ++ DG + L A +GH ++V L+ + G ALH
Sbjct: 126 VVKFLLEN-GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR-----LPALHI 179
Query: 246 AARGGHTPILDRLLLMG-TPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDG 304
AAR T LL P + G TPLH AA + Q L++ + ++G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 305 YTAADLAEYHGH 316
T +A G+
Sbjct: 240 ITPLHIASRRGN 251
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/162 (29%), Positives = 81/162 (50%), Gaps = 3/162 (1%)
Query: 163 SVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVV 222
SV R A+ A + G+L A +++ G D++ +G++ LH A+ GH +VV
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRN-GVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 223 WLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAEN 281
L+ +I L +G TALH AA G ++ L+ G + S G TPL+ AA+
Sbjct: 63 ELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 282 GQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
+E + L+ + + ++ EDG+T +A GH + +L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 7/100 (7%)
Query: 230 IGLTARDNEGATALHFAARGGHTPILDRLL----LMGTPILRDSWGGTPLHDAAENGQME 285
+ + + G LH A++ GH ++ LL ++ T + G T LH AA GQ E
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKK---GNTALHIAALAGQDE 92
Query: 286 CCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ LV++ + + + + G+T +A H + ++L E
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 124 bits (310), Expect = 6e-28
Identities = 116/399 (29%), Positives = 178/399 (44%), Gaps = 26/399 (6%)
Query: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
L AA G + + LL GA I D+ G ++ A+ G+++ V+ L+ R L N R
Sbjct: 786 LAAASMGHASVVNTLLFWGAAVDSI-DSEGRTVLSIASAQGNVEVVRTLLDRG-LDENHR 843
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
G TP H AA G +C + E G + D G P LA++ GH V+ LL
Sbjct: 844 DDAGWTPLHMAAFEGHRL-ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
+ +G L AA+ G ++LL + HG+ VN + G LY+ E L +
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFS-HGADVNCKDADGRPTLYILALENQLTM 961
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
A++ +++ GA+V +G +ALH + +GH +V L+ + + A DNE +AL A
Sbjct: 962 AEYFLEN-GANVEASDAEGRTALHVSCWQGHMEMVQVLIAY-HADVNAADNEKRSALQSA 1019
Query: 247 ARGGHTPILDRLLLMGTPILRD-SWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
A GH ++ L+ G + + G T L AA+ G ++ Q L+ H DP+ D+ G
Sbjct: 1020 AWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR 1079
Query: 306 TAADLAEYHGHRDCAQYLREVA---------QPVPLLMTPPPPPFPPPPLLATRRSLEDG 356
TA +A +GH + L + PV + P T +S G
Sbjct: 1080 TAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSG 1139
Query: 357 RRGGPGPGNPSPMSLSPAWPGH--------PDQPLPREQ 387
GG G PS L P P H PD + R++
Sbjct: 1140 STGG-GDMQPSLRGL-PNGPTHAFSSPSESPDSTVDRQK 1176
Score = 106 bits (265), Expect = 1e-22
Identities = 100/324 (30%), Positives = 143/324 (44%), Gaps = 12/324 (3%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA+ G + L+ GA TD G + A GH + V L+ A
Sbjct: 584 LAARQGHTKVVNCLIGCGA-NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV--DCA 640
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+ A AAA G ++ + + G + D G + L AA GH +VE LL G
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 128 HSATLETREGARPLHHAAV-----SGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEG 182
E +G L AA+ G + + LL G+ V+ + G +PL +A EG
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID-RGAEVDHCDKDGMTPLLVAAYEG 759
Query: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATA 242
H+ + L++ GADV +G + L AAA+ GH S+V L+ F + + D+EG T
Sbjct: 760 HVDVVDLLLEG-GADVDHTDNNGRTPLLAAASMGHASVVNTLL-FWGAAVDSIDSEGRTV 817
Query: 243 LHFAARGGHTPILDRLLLMGTPIL-RDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRD 301
L A+ G+ ++ LL G RD G TPLH AA G C+ L+ + D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 302 EDGYTAADLAEYHGHRDCAQYLRE 325
DG LA GH DC Q L E
Sbjct: 878 NDGRIPFILASQEGHYDCVQILLE 901
Score = 99.8 bits (247), Expect = 1e-20
Identities = 91/320 (28%), Positives = 139/320 (43%), Gaps = 9/320 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
V A G + + L++ GA D G + A GH+D V L++ +
Sbjct: 721 VPASKGHASVVSLLIDRGA-EVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA-DVDHTD 778
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+NG TP AA+ G + + L+ G + D+ G + L +A+ G+ +V LL G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLF-WGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 128 HSATLETREGARPLHHAAVSGD-LTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G PLH AA G L C L+ G+ N G P LA QEGH
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIE--QGARTNEIDNDGRIPFILASQEGHYDC 895
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
Q L+++ +++ R DG +AL AA GH +V L + + +D +G L+
Sbjct: 896 VQILLEN-KSNIDQRGYDGRNALRVAALEGHRDIVELLFSH-GADVNCKDADGRPTLYIL 953
Query: 247 ARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
A + + L G + D+ G T LH + G ME Q L+++H D + D +
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
Query: 306 TAADLAEYHGHRDCAQYLRE 325
+A A + GH Q L E
Sbjct: 1014 SALQSAAWQGHVKVVQLLIE 1033
Score = 94.7 bits (234), Expect = 4e-19
Identities = 95/332 (28%), Positives = 138/332 (41%), Gaps = 72/332 (21%)
Query: 64 NQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWL 123
NQ NG T +AA +GSL + LV G L+ +DA G +PL LAAR GH +V L
Sbjct: 539 NQCDSNGRTLLANAAYSGSLDVVNLLVSRGA-DLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 124 LHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAA------------------------ 159
+ G + ++G L AA G + L A
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
Query: 160 --------HGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHA 211
HG+ VN+ G + L A GH + + L+ D GA+V+ +DG +AL
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL-DHGAEVNHEDVDGRTALSV 716
Query: 212 A-----AARGHYSLVVWLVT------------FTDIGLTA-------------------- 234
A A++GH S+V L+ T + + A
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 235 RDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSH 293
DN G T L AA GH +++ LL G + DS G T L A+ G +E +TL+
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 294 HVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+D + RD+ G+T +A + GHR + L E
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868
Score = 75.9 bits (185), Expect = 2e-13
Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 3/165 (1%)
Query: 160 HGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYS 219
+G+SVN+ +G + L A G L + LV GAD+ + G + L AA +GH
Sbjct: 534 NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSR-GADLEIEDAHGHTPLTLAARQGHTK 592
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDA 278
+V L+ + D +G TAL AA GGHT ++ LL G + D+ T L A
Sbjct: 593 VVNCLIG-CGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 279 AENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
A G + L+ H + + D +G TA A Y GHR+ ++L
Sbjct: 652 AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 123 bits (308), Expect = 1e-27
Identities = 101/356 (28%), Positives = 153/356 (42%), Gaps = 43/356 (12%)
Query: 3 KQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLP 62
K AL+ D + +++ G T +H A G+++ L+ R
Sbjct: 185 KSAALLLQNDHNADVQSKMMVNRTTESGFTP------LHIAAHYGNVNVATLLLNRGAAV 238
Query: 63 GNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEW 122
+ A NG TP H A+ G+ + L+ GG + + G++PLH AAR GH +VE
Sbjct: 239 -DFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVEL 296
Query: 123 LLHEGHSATLETREGARPLHHAAVSGDLTCLK---------------LLTAAH------- 160
LL G T+ G PLH AA + C+K LTA H
Sbjct: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 356
Query: 161 ----------GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALH 210
++ N R +G +PL++AC++ + + + LVK GA + G++ +H
Sbjct: 357 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIH 415
Query: 211 AAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDS 269
AA GH ++V+ L+ + G TALH AAR G ++ LL G + R
Sbjct: 416 VAAFMGHLNIVLLLLQ-NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 474
Query: 270 WGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
TPLH A+ G+ E Q L+ H P +GYT ++ G D A L E
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Score = 118 bits (296), Expect = 2e-26
Identities = 94/318 (29%), Positives = 155/318 (48%), Gaps = 9/318 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAA G + + LL+ GA P +T+ G +H A RAG ++ V+ L++ L + RA
Sbjct: 416 VAAFMGHLNIVLLLLQNGA-SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV-DARA 473
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
TP H A+ G E+ L+ + +G +PLH++AR G + LL G
Sbjct: 474 REEQTPLHIASRLGK-TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 532
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ +L T++G PLH AA G L KLL ++ + ++G +PL++A + +A
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHYDNQKVA 591
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTF-TDIGLTARDNEGATALHFA 246
L++ GA H A +G + LH AA + + L+ + + + + +G T LH A
Sbjct: 592 LLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK--QGVTPLHLA 648
Query: 247 ARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
++ GHT ++ LL G I + G T LH AA+ ++ L H D + GY
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
Query: 306 TAADLAEYHGHRDCAQYL 323
T +A ++G+ +L
Sbjct: 709 TPLIVACHYGNVKMVNFL 726
Score = 116 bits (290), Expect = 1e-25
Identities = 96/336 (28%), Positives = 154/336 (45%), Gaps = 8/336 (2%)
Query: 2 EKQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
E+Q L +A++ G ++ LL+ A P G +H + R G +D L++ A
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMA-HPDAATTNGYTPLHISAREGQVDVASVLLE-AG 532
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
+ G TP H AA GSL ++ L+ + +G++PLH+AA + + +
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSL-DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 591
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
LL +G S + G PLH AA + L +G+ N T+ G +PL+LA Q
Sbjct: 592 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNIVTKQGVTPLHLASQ 650
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
EGH + L+ D GA++H+ G+++LH AA + V ++T A G
Sbjct: 651 EGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVN-VADILTKHGADQDAHTKLGY 708
Query: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSL 299
T L A G+ +++ LL G + + G TPLH AA+ G L+ H P+
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 300 RDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMT 335
+G TA +A+ G+ L+ V + V T
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTT 804
Score = 98.2 bits (243), Expect = 3e-20
Identities = 79/291 (27%), Positives = 132/291 (45%), Gaps = 40/291 (13%)
Query: 77 AAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
AA G+L ++ ++ GG + + +G++ LHLAA+ GH LV+ LL G S T++
Sbjct: 17 AARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196
G LH A+++G +K+L G+++N ++++G +PLY+A QE H+ + ++L+++ GA
Sbjct: 76 GNTALHIASLAGQAEVVKVLVK-EGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN-GA 133
Query: 197 DVHLRALDGMSALHAAAARGHYSLVVWL--------VTFTDIGLTARDNE---------- 238
+ DG + L A +GH V L V + + AR ++
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 239 ------------------GATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAA 279
G T LH AA G+ + LL G + + G TPLH A+
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253
Query: 280 ENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
+ G + L+ + DG T A GH + L E P+
Sbjct: 254 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
Score = 52.0 bits (123), Expect = 3e-06
Identities = 40/120 (33%), Positives = 57/120 (47%), Gaps = 3/120 (2%)
Query: 207 SALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI- 265
S L AA A +V +L DI T N G ALH AA+ GH ++ LL G+ +
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDIN-TCNQN-GLNALHLAAKEGHVGLVQELLGRGSSVD 70
Query: 266 LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
G T LH A+ GQ E + LV + + + ++G+T +A H D +YL E
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 123 bits (308), Expect = 1e-27
Identities = 101/356 (28%), Positives = 153/356 (42%), Gaps = 43/356 (12%)
Query: 3 KQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLP 62
K AL+ D + +++ G T +H A G+++ L+ R
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTP------LHIAAHYGNVNVATLLLNRGAAV 259
Query: 63 GNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEW 122
+ A NG TP H A+ G+ + L+ GG + + G++PLH AAR GH +VE
Sbjct: 260 -DFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 123 LLHEGHSATLETREGARPLHHAAVSGDLTCLK---------------LLTAAH------- 160
LL G T+ G PLH AA + C+K LTA H
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
Query: 161 ----------GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALH 210
++ N R +G +PL++AC++ + + + LVK GA + G++ +H
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIH 436
Query: 211 AAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDS 269
AA GH ++V+ L+ + G TALH AAR G ++ LL G + R
Sbjct: 437 VAAFMGHLNIVLLLLQ-NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495
Query: 270 WGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
TPLH A+ G+ E Q L+ H P +GYT ++ G D A L E
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 118 bits (296), Expect = 2e-26
Identities = 94/318 (29%), Positives = 155/318 (48%), Gaps = 9/318 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAA G + + LL+ GA P +T+ G +H A RAG ++ V+ L++ L + RA
Sbjct: 437 VAAFMGHLNIVLLLLQNGA-SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV-DARA 494
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
TP H A+ G E+ L+ + +G +PLH++AR G + LL G
Sbjct: 495 REEQTPLHIASRLGK-TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ +L T++G PLH AA G L KLL ++ + ++G +PL++A + +A
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTF-TDIGLTARDNEGATALHFA 246
L++ GA H A +G + LH AA + + L+ + + + + +G T LH A
Sbjct: 613 LLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK--QGVTPLHLA 669
Query: 247 ARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
++ GHT ++ LL G I + G T LH AA+ ++ L H D + GY
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 306 TAADLAEYHGHRDCAQYL 323
T +A ++G+ +L
Sbjct: 730 TPLIVACHYGNVKMVNFL 747
Score = 116 bits (290), Expect = 1e-25
Identities = 96/336 (28%), Positives = 154/336 (45%), Gaps = 8/336 (2%)
Query: 2 EKQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
E+Q L +A++ G ++ LL+ A P G +H + R G +D L++ A
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMA-HPDAATTNGYTPLHISAREGQVDVASVLLE-AG 553
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
+ G TP H AA GSL ++ L+ + +G++PLH+AA + + +
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSL-DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
LL +G S + G PLH AA + L +G+ N T+ G +PL+LA Q
Sbjct: 613 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNIVTKQGVTPLHLASQ 671
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
EGH + L+ D GA++H+ G+++LH AA + V ++T A G
Sbjct: 672 EGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVN-VADILTKHGADQDAHTKLGY 729
Query: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSL 299
T L A G+ +++ LL G + + G TPLH AA+ G L+ H P+
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 300 RDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMT 335
+G TA +A+ G+ L+ V + V T
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTT 825
Score = 98.2 bits (243), Expect = 3e-20
Identities = 79/291 (27%), Positives = 132/291 (45%), Gaps = 40/291 (13%)
Query: 77 AAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
AA G+L ++ ++ GG + + +G++ LHLAA+ GH LV+ LL G S T++
Sbjct: 38 AARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196
G LH A+++G +K+L G+++N ++++G +PLY+A QE H+ + ++L+++ GA
Sbjct: 97 GNTALHIASLAGQAEVVKVLVK-EGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN-GA 154
Query: 197 DVHLRALDGMSALHAAAARGHYSLVVWL--------VTFTDIGLTARDNE---------- 238
+ DG + L A +GH V L V + + AR ++
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 239 ------------------GATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAA 279
G T LH AA G+ + LL G + + G TPLH A+
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 280 ENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
+ G + L+ + DG T A GH + L E P+
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Score = 62.8 bits (151), Expect = 2e-09
Identities = 51/170 (30%), Positives = 83/170 (48%), Gaps = 6/170 (3%)
Query: 160 HGSSVNRRT--RSGASPLYL-ACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARG 216
+GSS R+ +S ++ +L A + G+L +K G D++ +G++ALH AA G
Sbjct: 17 NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEG 75
Query: 217 HYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPL 275
H LV L+ + + +G TALH A+ G ++ L+ G I S G TPL
Sbjct: 76 HVGLVQELLG-RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
Query: 276 HDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ AA+ ++ + L+ + + S EDG+T +A GH L E
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 123 bits (308), Expect = 1e-27
Identities = 101/356 (28%), Positives = 153/356 (42%), Gaps = 43/356 (12%)
Query: 3 KQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLP 62
K AL+ D + +++ G T +H A G+++ L+ R
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTP------LHIAAHYGNVNVATLLLNRGAAV 259
Query: 63 GNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEW 122
+ A NG TP H A+ G+ + L+ GG + + G++PLH AAR GH +VE
Sbjct: 260 -DFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 123 LLHEGHSATLETREGARPLHHAAVSGDLTCLK---------------LLTAAH------- 160
LL G T+ G PLH AA + C+K LTA H
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
Query: 161 ----------GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALH 210
++ N R +G +PL++AC++ + + + LVK GA + G++ +H
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIH 436
Query: 211 AAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDS 269
AA GH ++V+ L+ + G TALH AAR G ++ LL G + R
Sbjct: 437 VAAFMGHLNIVLLLLQ-NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAR 495
Query: 270 WGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
TPLH A+ G+ E Q L+ H P +GYT ++ G D A L E
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Score = 118 bits (296), Expect = 2e-26
Identities = 94/318 (29%), Positives = 155/318 (48%), Gaps = 9/318 (2%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
VAA G + + LL+ GA P +T+ G +H A RAG ++ V+ L++ L + RA
Sbjct: 437 VAAFMGHLNIVLLLLQNGA-SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV-DARA 494
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
TP H A+ G E+ L+ + +G +PLH++AR G + LL G
Sbjct: 495 REEQTPLHIASRLGK-TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAG 553
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ +L T++G PLH AA G L KLL ++ + ++G +PL++A + +A
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR-AAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTF-TDIGLTARDNEGATALHFA 246
L++ GA H A +G + LH AA + + L+ + + + + +G T LH A
Sbjct: 613 LLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK--QGVTPLHLA 669
Query: 247 ARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
++ GHT ++ LL G I + G T LH AA+ ++ L H D + GY
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 306 TAADLAEYHGHRDCAQYL 323
T +A ++G+ +L
Sbjct: 730 TPLIVACHYGNVKMVNFL 747
Score = 116 bits (290), Expect = 1e-25
Identities = 96/336 (28%), Positives = 154/336 (45%), Gaps = 8/336 (2%)
Query: 2 EKQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
E+Q L +A++ G ++ LL+ A P G +H + R G +D L++ A
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMA-HPDAATTNGYTPLHISAREGQVDVASVLLE-AG 553
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
+ G TP H AA GSL ++ L+ + +G++PLH+AA + + +
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSL-DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVA 612
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
LL +G S + G PLH AA + L +G+ N T+ G +PL+LA Q
Sbjct: 613 LLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN-YGAETNIVTKQGVTPLHLASQ 671
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
EGH + L+ D GA++H+ G+++LH AA + V ++T A G
Sbjct: 672 EGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVN-VADILTKHGADQDAHTKLGY 729
Query: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVSHHVDPSL 299
T L A G+ +++ LL G + + G TPLH AA+ G L+ H P+
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 300 RDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMT 335
+G TA +A+ G+ L+ V + V T
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTT 825
Score = 98.2 bits (243), Expect = 3e-20
Identities = 79/291 (27%), Positives = 132/291 (45%), Gaps = 40/291 (13%)
Query: 77 AAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
AA G+L ++ ++ GG + + +G++ LHLAA+ GH LV+ LL G S T++
Sbjct: 38 AARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196
G LH A+++G +K+L G+++N ++++G +PLY+A QE H+ + ++L+++ GA
Sbjct: 97 GNTALHIASLAGQAEVVKVLVK-EGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN-GA 154
Query: 197 DVHLRALDGMSALHAAAARGHYSLVVWL--------VTFTDIGLTARDNE---------- 238
+ DG + L A +GH V L V + + AR ++
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 239 ------------------GATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPLHDAA 279
G T LH AA G+ + LL G + + G TPLH A+
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 280 ENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
+ G + L+ + DG T A GH + L E P+
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Score = 62.8 bits (151), Expect = 2e-09
Identities = 51/170 (30%), Positives = 83/170 (48%), Gaps = 6/170 (3%)
Query: 160 HGSSVNRRT--RSGASPLYL-ACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARG 216
+GSS R+ +S ++ +L A + G+L +K G D++ +G++ALH AA G
Sbjct: 17 NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEG 75
Query: 217 HYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGG-TPL 275
H LV L+ + + +G TALH A+ G ++ L+ G I S G TPL
Sbjct: 76 HVGLVQELLG-RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 134
Query: 276 HDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+ AA+ ++ + L+ + + S EDG+T +A GH L E
Sbjct: 135 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 184
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 120 bits (302), Expect = 5e-27
Identities = 111/372 (29%), Positives = 163/372 (43%), Gaps = 48/372 (12%)
Query: 2 EKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQL 61
E +RA + LE LL+ A P I D G +H+A GH C++ L++R
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDA-NPSIRDKEGYNSIHYAAAYGHRQCLELLLERTN- 531
Query: 62 PGNQRAHNGAT--PAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVL 119
G + + +GAT P H AA G L L+ + L +D G + L LAA GH
Sbjct: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLL-QSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 120 VEWLLHEGHSATLETREGAR-PLHHAAVSGDLTCLKLL--TAAHGSSVNRRTRSGASPLY 176
VE L++ G S ++ R PLH + ++G CL+LL A + +V+ + G +PL
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 177 LACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARD 236
LA GH+ L++ A+V + G +ALH GH V L+ ++ + +D
Sbjct: 651 LAVAYGHIDAVSLLLEK-EANVDTVDILGCTALHRGIMTGHEECVQMLLE-QEVSILCKD 708
Query: 237 NEGATALHFAARGGHTPILDRLLLMGTP----ILRDSWGGTPLHDAAENGQMEC------ 286
+ G T LH+AA GH L LL M +D+ G TPLH A NG C
Sbjct: 709 SRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Query: 287 -------------------------CQTLVSHHVDPSL---RDEDGYTAADLAEYHGHRD 318
C +L+ +D S+ RD+ G T A + H +
Sbjct: 769 QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVE 828
Query: 319 CAQYLREVAQPV 330
C Q L + PV
Sbjct: 829 CLQLLLRHSAPV 840
Score = 117 bits (292), Expect = 7e-26
Identities = 106/380 (27%), Positives = 161/380 (42%), Gaps = 69/380 (18%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGH-LDCVKFLVQRAQLPGNQR 66
+A +G A + L++ GA + G +H A + H C++ LV N +
Sbjct: 220 IACYNGQDAVVNELIDYGA-NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGA-DVNIQ 277
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
+ +G +P H A G L++ GG + D G +PLH+AAR+GH +L+ L
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQNGG-EIDCVDKDGNTPLHVAARYGHELLINTLRTS 336
Query: 127 G--------------HSATLETRE-------------------GARPLHHAAVSGDLTCL 153
G H A L G LH AA G++ C+
Sbjct: 337 GADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECI 396
Query: 154 KLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAA 213
KLL ++ G+ +++ + G +PL+ A H H + LV GA+V+ G +ALH AA
Sbjct: 397 KLLQSS-GADFHKKDKCGRTPLHYAAANCHFHCIETLVTT-GANVNETDDWGRTALHYAA 454
Query: 214 ARG---------------------------HYSLVVWLVTFTDIGLTARDNEGATALHFA 246
A +L + + D + RD EG ++H+A
Sbjct: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYA 514
Query: 247 ARGGHTPILDRLLLMGTPILRDSWGG---TPLHDAAENGQMECCQTLVSHHVDPSLRDED 303
A GH L+ LL +S G +PLH AA NG + + L+ VD +RDE
Sbjct: 515 AAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK 574
Query: 304 GYTAADLAEYHGHRDCAQYL 323
G TA DLA + GH +C + L
Sbjct: 575 GRTALDLAAFKGHTECVEAL 594
Score = 107 bits (268), Expect = 4e-23
Identities = 97/318 (30%), Positives = 142/318 (44%), Gaps = 10/318 (3%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQLPGNQRA 67
AA +G V + LL GA D +H A GHLD V L+ A++ +
Sbjct: 122 AALNGHVEMVNLLLAKGA-NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK- 179
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
G TP H AA+ G + + L+ G + + + G + LH+A G +V L+ G
Sbjct: 180 -KGYTPLHAAASNGQINVVKHLLNLG-VEIDEINVYGNTALHIACYNGQDAVVNELIDYG 237
Query: 128 HSATLETREGARPLHHAAVS-GDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
+ G PLH AA S CL+LL +G+ VN +++ G SPL++ G
Sbjct: 238 ANVNQPNNNGFTPLHFAAASTHGALCLELL-VNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+Q L+++ G ++ DG + LH AA GH L+ L T + LH A
Sbjct: 297 SQTLIQN-GGEIDCVDKDGNTPLHVAARYGHELLINTLRT-SGADTAKCGIHSMFPLHLA 354
Query: 247 ARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
A H+ +LL G I D +G T LH AA G +EC + L S D +D+ G
Sbjct: 355 ALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR 414
Query: 306 TAADLAEYHGHRDCAQYL 323
T A + H C + L
Sbjct: 415 TPLHYAAANCHFHCIETL 432
Score = 105 bits (262), Expect = 2e-22
Identities = 87/296 (29%), Positives = 137/296 (46%), Gaps = 7/296 (2%)
Query: 31 ITDALGAGLVHHATRAGHLDCVKFLVQR-AQLPGNQRAHNGATPAHDAAATGSLAELCWL 89
++D G +HHA GH++ V L+ + A + + A H AA G L + L
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA--LHWAAYMGHLDVVALL 167
Query: 90 VREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGD 149
+ G + +D G +PLH AA G +V+ LL+ G G LH A +G
Sbjct: 168 INH-GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226
Query: 150 LTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSAL 209
+ L +G++VN+ +G +PL+ A H L L+ + GADV++++ DG S L
Sbjct: 227 DAVVNEL-IDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285
Query: 210 HAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDS 269
H A G ++ L+ + D +G T LH AAR GH +++ L G +
Sbjct: 286 HMTAVHGRFTRSQTLIQ-NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344
Query: 270 WGGT-PLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLR 324
PLH AA N +CC+ L+S + D+ G T A G+ +C + L+
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQ 400
Score = 91.7 bits (226), Expect = 3e-18
Identities = 96/336 (28%), Positives = 141/336 (41%), Gaps = 16/336 (4%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPG--NQ 65
+AA G +E L+ GA + +H + GH C++ L++ A P +
Sbjct: 581 LAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDV 640
Query: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
+ G TP A A G + + L+ E + D G + LH GH V+ LL
Sbjct: 641 KDAKGQTPLMLAVAYGHIDAVSLLL-EKEANVDTVDILGCTALHRGIMTGHEECVQMLLE 699
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLK--LLTAAHGSSVNRRTRSGASPLYLACQEGH 183
+ S + G PLH+AA G T L L A + G +PL+ AC G+
Sbjct: 700 QEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGN 759
Query: 184 LHLAQFLVKD-CGADVHLRALDG--MSALHAAAARGHYSLVVWLVTFTDIGLTA-RDNEG 239
+ + L++ C R G + LH A H + L+ D + + RD++G
Sbjct: 760 ENCIEVLLEQKC-----FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKG 814
Query: 240 ATALHFAARGGHTPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQTLV-SHHVDP 297
T L AA H L LL P+ D+ G T L AAENGQ LV S D
Sbjct: 815 RTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADL 874
Query: 298 SLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLL 333
+++D+D T LA GH CA + + Q L+
Sbjct: 875 TVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLI 910
Score = 89.4 bits (220), Expect = 2e-17
Identities = 69/234 (29%), Positives = 112/234 (47%), Gaps = 8/234 (3%)
Query: 101 DASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAH 160
D+ +PLH+AA G ++E L+ G + PLH A S +++L H
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL-IKH 71
Query: 161 GSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSL 220
+ VN R ++ +PL++A + A+ ++ + V++ G +ALH AA GH +
Sbjct: 72 SADVNARDKNWQTPLHVAAANKAVKCAEVII-PLLSSVNVSDRGGRTALHHAALNGHVEM 130
Query: 221 VVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAA 279
V L+ + A D + ALH+AA GH ++ L+ G + +D G TPLH AA
Sbjct: 131 VNLLLA-KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
Query: 280 ENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGH----RDCAQYLREVAQP 329
NGQ+ + L++ V+ + G TA +A Y+G + Y V QP
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243
Score = 89.0 bits (219), Expect = 2e-17
Identities = 71/246 (28%), Positives = 110/246 (44%), Gaps = 5/246 (2%)
Query: 72 TPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSAT 131
TP H AA G AE+ L+ G + +D ++PLH A V+ L+
Sbjct: 18 TPLHVAAFLGD-AEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 132 LETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLV 191
+ PLH AA + + C +++ SSVN R G + L+ A GH+ + L+
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPLL-SSVNVSDRGGRTALHHAALNGHVEMVNLLL 135
Query: 192 KDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGH 251
GA+++ ALH AA GH +V L+ +T +D +G T LH AA G
Sbjct: 136 AK-GANINAFDKKDRRALHWAAYMGHLDVVALLINH-GAEVTCKDKKGYTPLHAAASNGQ 193
Query: 252 TPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADL 310
++ LL +G I + +G T LH A NGQ L+ + + + + +G+T
Sbjct: 194 INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHF 253
Query: 311 AEYHGH 316
A H
Sbjct: 254 AAASTH 259
Score = 79.3 bits (194), Expect = 2e-14
Identities = 81/268 (30%), Positives = 115/268 (42%), Gaps = 29/268 (10%)
Query: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
++A G + + LLE A D LG +H GH +CV+ L+++ ++ +
Sbjct: 650 MLAVAYGHIDAVSLLLEKEA-NVDTVDILGCTALHRGIMTGHEECVQMLLEQ-EVSILCK 707
Query: 67 AHNGATPAHDAAATGSLAELCWLVR----EGGCGLQDQDASGVSPLHLAARFGHPVLVEW 122
G TP H AAA G L L++ E C +D G +PLH A G+ +E
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ--GYTPLHWACYNGNENCIEV 765
Query: 123 LLHE-------GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSS-VNRRTRSGASP 174
LL + G+ T PLH A ++ C LL A SS V+ R G +P
Sbjct: 766 LLEQKCFRKFIGNPFT--------PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817
Query: 175 LYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTA 234
L A H+ Q L++ A V+ G +AL AA G V LV LT
Sbjct: 818 LRAAAFADHVECLQLLLRH-SAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTV 876
Query: 235 RDNEGATALHFAARGGHTP----ILDRL 258
+D + T LH A GH ILD++
Sbjct: 877 KDKDLNTPLHLACSKGHEKCALLILDKI 904
Score = 76.6 bits (187), Expect = 1e-13
Identities = 59/202 (29%), Positives = 90/202 (44%), Gaps = 4/202 (1%)
Query: 123 LLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEG 182
L+H+ E PLH AA GD ++LL + G+ VN + +PL+ A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILS-GARVNAKDNMWLTPLHRAVASR 60
Query: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATA 242
Q L+K ADV+ R + + LH AAA ++ + D G TA
Sbjct: 61 SEEAVQVLIKH-SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS-SVNVSDRGGRTA 118
Query: 243 LHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRD 301
LH AA GH +++ LL G I D LH AA G ++ L++H + + +D
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 302 EDGYTAADLAEYHGHRDCAQYL 323
+ GYT A +G + ++L
Sbjct: 179 KKGYTPLHAAASNGQINVVKHL 200
Score = 48.1 bits (113), Expect = 4e-05
Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 236 DNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHH 294
D+E T LH AA G I++ L+L G + +D+ TPLH A + E Q L+ H
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 295 VDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLL 333
D + RD++ T +A + CA+ + +PLL
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVI------IPLL 105
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 117 bits (293), Expect = 5e-26
Identities = 91/258 (35%), Positives = 122/258 (47%), Gaps = 5/258 (1%)
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
N TP H A GS+ ++ L+ + Q ASG +PL +AA+ P L LL G
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQ 188
A +G PLH AA +GD +LL HG+ V+ + R G +PL+LA Q ++A+
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLD-HGACVDAQEREGWTPLHLAAQNNFENVAR 478
Query: 189 FLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAAR 248
LV AD +L +G + LH AA GH SLV L+T L A+ T LH A
Sbjct: 479 LLVSR-QADPNLHEAEGKTPLHVAAYFGHVSLVK-LLTSQGAELDAQQRNLRTPLHLAVE 536
Query: 249 GGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTA 307
G + LL G P D G PLH AA G+ C+ L+ + L G+T
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTP 596
Query: 308 ADLAEYHGHRDCAQYLRE 325
LA Y GH + L E
Sbjct: 597 LHLAAYKGHLEIIHLLAE 614
Score = 103 bits (257), Expect = 8e-22
Identities = 87/268 (32%), Positives = 126/268 (47%), Gaps = 8/268 (2%)
Query: 10 AKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLV-QRAQLPGNQRAH 68
A + + RLL + P + +A G +H A GH+ VK L Q A+L QR
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR-- 525
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
N TP H A G + + L++ G D SG PLH AA G ++ + LL G
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQ 188
S L T +G PLH AA G L + LL +H +++ +PL+LA + G +
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESH-ANMGALGAVNWTPLHLAARHGEEAVVS 643
Query: 189 FLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAAR 248
L++ CGAD + G + LH A R + V+ L+ + AR+ G T H AA
Sbjct: 644 ALLQ-CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH-HANVHARNKVGWTPAHLAAL 701
Query: 249 GGHTPILDRLLLMGTPI-LRDSWGGTPL 275
G+T IL L+ G + ++D TPL
Sbjct: 702 KGNTAILKVLVEAGAQLDVQDGVSCTPL 729
Score = 102 bits (255), Expect = 1e-21
Identities = 92/320 (28%), Positives = 139/320 (43%), Gaps = 7/320 (2%)
Query: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
L+AA+D LL GA + D G +H A + G + L+ Q
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRV-DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE 458
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
G TP H AA + + L+ +A G +PLH+AA FGH LV+ L +
Sbjct: 459 -REGWTPLH-LAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 516
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G + R PLH A G + ++ L + G+ + +SG PL+ A G +
Sbjct: 517 GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS-GAVPDALDQSGYGPLHTAAARGKYLI 575
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
+ L++ GA + L G + LH AA +GH ++ L+ + + A T LH A
Sbjct: 576 CKMLLR-YGASLELPTHQGWTPLHLAAYKGHLE-IIHLLAESHANMGALGAVNWTPLHLA 633
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AR G ++ LL G P + G TPLH A + L+ HH + R++ G+
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGW 693
Query: 306 TAADLAEYHGHRDCAQYLRE 325
T A LA G+ + L E
Sbjct: 694 TPAHLAALKGNTAILKVLVE 713
Score = 88.6 bits (218), Expect = 3e-17
Identities = 86/308 (27%), Positives = 131/308 (42%), Gaps = 43/308 (13%)
Query: 40 VHHATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQD 99
+H G ++ V+ L+ ++ + + +G TP AA +LC L+ G
Sbjct: 366 LHFLVAQGSVEQVRLLLAH-EVDVDCQTASGYTPLL-IAAQDQQPDLCALLLAHGADANR 423
Query: 100 QDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVS------------ 147
D G +PLH AA+ G LL G + REG PLH AA +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 148 ---------------------GDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G ++ +KLLT + G+ ++ + R+ +PL+LA + G +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLT-SQGAELDAQQRNLRTPLHLAVERGKVRA 542
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
Q L+K GA G LH AAARG Y + L+ + L ++G T LH A
Sbjct: 543 IQHLLKS-GAVPDALDQSGYGPLHTAAARGKYLICKMLLRY-GASLELPTHQGWTPLHLA 600
Query: 247 ARGGHTPILDRLLLMGTPILRDSWGG---TPLHDAAENGQMECCQTLVSHHVDPSLRDED 303
A GH I+ LL + + G TPLH AA +G+ L+ DP+ ++
Sbjct: 601 AYKGHLEIIH--LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQS 658
Query: 304 GYTAADLA 311
G+T LA
Sbjct: 659 GWTPLHLA 666
Score = 35.4 bits (80), Expect = 0.27
Identities = 42/167 (25%), Positives = 67/167 (40%), Gaps = 6/167 (3%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA G + + L E+ A G A+ +H A R G V L+Q P N
Sbjct: 599 LAAYKGHLEIIHLLAESHA-NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP-NAAE 656
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+G TP H A + + L+ E + ++ G +P HLAA G+ +++ L+ G
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLL-EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASP 174
++ PL A S + L G + T G+ P
Sbjct: 716 AQLDVQDGVSCTPLQLALRSRKQGIMSFL---EGKEPSVATLGGSKP 759
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 114 bits (285), Expect = 5e-25
Identities = 107/395 (27%), Positives = 168/395 (42%), Gaps = 76/395 (19%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQLPGNQRA 67
AA G ++ LL GA D +H A GH++ VK LV A++ +
Sbjct: 147 AAFSGHGEMVKLLLSRGA-NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDK- 204
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
TP H AA++G ++ + +L+ + G + + +A G +PLH+A G V+V L+ G
Sbjct: 205 -KSYTPLHAAASSGMISVVKYLL-DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCG 262
Query: 128 HSATLETREGARPLHHAAVS-GDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
+ +G PLH AA S CL+LL +G+ VN +++ G +PL++ G
Sbjct: 263 AIVNQKNEKGFTPLHFAAASTHGALCLELL-VGNGADVNMKSKDGKTPLHMTALHGRFSR 321
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVT-------------------- 226
+Q +++ GA + +G + LH AA GH L+ L+T
Sbjct: 322 SQTIIQS-GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
Query: 227 ---FTD---------IGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGT 273
F+D + D+ G T LH AA GG+ L+ LL G +D +G +
Sbjct: 381 LSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRS 440
Query: 274 PLHDAAENGQMECCQTLVS----------------------------------HHVDPSL 299
PLH AA N +C LV + +P +
Sbjct: 441 PLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
Query: 300 RDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLM 334
RD+ GY A + +GHR C Q + P+ +LM
Sbjct: 501 RDKQGYNAVHYSAAYGHRLCLQLIAS-ETPLDVLM 534
Score = 110 bits (275), Expect = 7e-24
Identities = 99/363 (27%), Positives = 156/363 (42%), Gaps = 52/363 (14%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGH-LDCVKFLVQRAQLPGNQR 66
VA +G + L++ GA+ + G +H A + H C++ LV N +
Sbjct: 245 VACYNGQDVVVNELIDCGAI-VNQKNEKGFTPLHFAAASTHGALCLELLVGNGA-DVNMK 302
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
+ +G TP H A G + +++ G + +D +G +PLH+AAR+GH +L+ L+
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELLINTLITS 361
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G G PLH AA+SG C + L ++ G ++ G + L+ A G+L
Sbjct: 362 GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSS-GFDIDTPDDFGRTCLHAAAAGGNLEC 420
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTF------------------- 227
L+ + GAD + + G S LH AAA +Y + LV
Sbjct: 421 LNLLL-NTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Query: 228 --------------TDIGLTARDNEGATALHFAARGGH----------TPILDRLLLMGT 263
D RD +G A+H++A GH TP+ + GT
Sbjct: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
Query: 264 PILRDSWGG---TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCA 320
+L DS +PLH AA +G + + LV +D +R+ G T DLA + GH +C
Sbjct: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
Query: 321 QYL 323
L
Sbjct: 600 DVL 602
Score = 108 bits (269), Expect = 3e-23
Identities = 92/324 (28%), Positives = 136/324 (41%), Gaps = 32/324 (9%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
A D D LE LL A PGI D G VH++ GH C++ + L
Sbjct: 479 ATSDTDGKCLEYLLRNDA-NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLD------ 531
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
+ + T L++ + + +SPLHLAA GH +E L+
Sbjct: 532 ----VLMETSGTDMLSD-------------SDNRATISPLHLAAYHGHHQALEVLVQSLL 574
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQ 188
+ G PL AA G + C+ +L S + + +P++ A GH +
Sbjct: 575 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 634
Query: 189 FLVKDCGAD--VHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
L+ + V ++ +G + L + GH V L+ + A+D G TALH
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN-KGANVDAKDKWGRTALHRG 693
Query: 247 ARGGHTPILDRLLLMGTP-ILRDSWGGTPLHDAAENGQM----ECCQTLVSHHVDPSLRD 301
A GH +D LL G +LRDS G TP+H +A G + Q+ S +P+ D
Sbjct: 694 AVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATAD 753
Query: 302 EDGYTAADLAEYHGHRDCAQYLRE 325
GYTA A Y+GH C + L E
Sbjct: 754 NHGYTALHWACYNGHETCVELLLE 777
Score = 104 bits (259), Expect = 5e-22
Identities = 79/255 (30%), Positives = 114/255 (44%), Gaps = 4/255 (1%)
Query: 70 GATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHS 129
G T H AA +G E+ L+ G + D +H AA GH +V+ L+ G
Sbjct: 140 GRTALHHAAFSGH-GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
Query: 130 ATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQF 189
T + ++ PLH AA SG ++ +K L G +N G +PL++AC G +
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDL-GVDMNEPNAYGNTPLHVACYNGQDVVVNE 257
Query: 190 LVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARG 249
L+ DCGA V+ + G + LH AAA H +L + L+ + + +G T LH A
Sbjct: 258 LI-DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316
Query: 250 GHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAA 308
G ++ G I D G TPLH AA G TL++ D + R G
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPL 376
Query: 309 DLAEYHGHRDCAQYL 323
LA G DC + L
Sbjct: 377 HLAALSGFSDCCRKL 391
Score = 98.6 bits (244), Expect = 3e-20
Identities = 92/318 (28%), Positives = 151/318 (47%), Gaps = 9/318 (2%)
Query: 2 EKQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQ 60
EK+ L AA GD +E L+ +GA D+ +H A + + V+ L++ +
Sbjct: 40 EKRTPLHAAAYLGDAEIIELLILSGAR-VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSA 98
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
N R N TP H AAA ++ LV + D +G + LH AA GH +V
Sbjct: 99 -DVNARDKNWQTPLHIAAANKAVKCAEALVPLLS-NVNVSDRAGRTALHHAAFSGHGEMV 156
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
+ LL G + ++ R +H AA G + +KLL +HG+ V + + +PL+ A
Sbjct: 157 KLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL-VSHGAEVTCKDKKSYTPLHAAAS 215
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
G + + ++L+ D G D++ G + LH A G +V L+ I + ++ +G
Sbjct: 216 SGMISVVKYLL-DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAI-VNQKNEKGF 273
Query: 241 TALHFAARGGHTPI-LDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPS 298
T LHFAA H + L+ L+ G + ++ G TPLH A +G+ QT++
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333
Query: 299 LRDEDGYTAADLAEYHGH 316
D++G T +A +GH
Sbjct: 334 CEDKNGNTPLHIAARYGH 351
Score = 98.6 bits (244), Expect = 3e-20
Identities = 98/358 (27%), Positives = 140/358 (39%), Gaps = 53/358 (14%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA G +LL +G D G +H A G+L+C+ L+ N++
Sbjct: 378 LAALSGFSDCCRKLLSSG-FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA-DFNKKD 435
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHP-VLVEWLLHE 126
G +P H AAA + L LV G + D D G +PLH AA +E+LL
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGA-SVNDLDERGCTPLHYAATSDTDGKCLEYLLRN 494
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRT-----------RSGASPL 175
+ + ++G +H++A G CL+L+ + V T R+ SPL
Sbjct: 495 DANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPL 554
Query: 176 YLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTF-------- 227
+LA GH + LV+ D+ +R G + L AA +GH V L+
Sbjct: 555 HLAAYHGHHQALEVLVQSL-LDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 228 -----TDIGLTA-----------------------RDNEGATALHFAARGGHTPILDRLL 259
T I A +D G T L + GHT + LL
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 260 LMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGH 316
G + +D WG T LH A G EC L+ H LRD G T L+ GH
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
Score = 96.7 bits (239), Expect = 1e-19
Identities = 93/325 (28%), Positives = 132/325 (40%), Gaps = 43/325 (13%)
Query: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
+++ +G + LL GA D G +H GH +CV L+Q R
Sbjct: 658 MLSVLNGHTDCVYSLLNKGA-NVDAKDKWGRTALHRGAVTGHEECVDALLQHGA-KCLLR 715
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGG---CGLQDQDASGVSPLHLAARFGHPVLVEWL 123
G TP H +AA G + L L++ D G + LH A GH VE L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 124 LHEG-------------HSATLETREGAR---------------------PLHHAAVSGD 149
L + H A + EGA PLH AA +
Sbjct: 776 LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 835
Query: 150 LTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSAL 209
+ CL+LL + H + VN +G +PL +A + G + + LV A++ L+ +AL
Sbjct: 836 VECLQLLLS-HNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 210 HAAAARGH-YSLVVWLVTFTDIGLTARDNEG-ATALHFAARGGHTPILDRLLLMGTPILR 267
H A ++GH S ++ L TD L N T LH AAR G T ++ LL G +L
Sbjct: 895 HLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLA 954
Query: 268 -DSWGGTPLHDAAENGQMECCQTLV 291
D G TP A N + C L+
Sbjct: 955 VDENGYTPALACAPNKDVADCLALI 979
Score = 84.0 bits (206), Expect = 7e-16
Identities = 64/217 (29%), Positives = 106/217 (48%), Gaps = 4/217 (1%)
Query: 100 QDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAA 159
QD +PLH AA G ++E L+ G + + PLH A S +++L
Sbjct: 37 QDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL-LK 95
Query: 160 HGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYS 219
H + VN R ++ +PL++A + A+ LV ++V++ G +ALH AA GH
Sbjct: 96 HSADVNARDKNWQTPLHIAAANKAVKCAEALV-PLLSNVNVSDRAGRTALHHAAFSGHGE 154
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDA 278
+V L++ + A D + A+H+AA GH ++ L+ G + +D TPLH A
Sbjct: 155 MVKLLLS-RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAA 213
Query: 279 AENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHG 315
A +G + + L+ VD + + G T +A Y+G
Sbjct: 214 ASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Score = 77.0 bits (188), Expect = 8e-14
Identities = 65/213 (30%), Positives = 92/213 (43%), Gaps = 4/213 (1%)
Query: 115 GHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASP 174
G P V L+ + + E PLH AA GD ++LL + G+ VN + +P
Sbjct: 19 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTP 77
Query: 175 LYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTA 234
L+ A Q L+K ADV+ R + + LH AAA LV +
Sbjct: 78 LHRAVASCSEEAVQVLLKH-SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS-NVNV 135
Query: 235 RDNEGATALHFAARGGHTPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQTLVSH 293
D G TALH AA GH ++ LL G I D +H AA G +E + LVSH
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Query: 294 HVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV 326
+ + +D+ YT A G +YL ++
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 228
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 114 bits (284), Expect = 6e-25
Identities = 96/321 (29%), Positives = 142/321 (44%), Gaps = 46/321 (14%)
Query: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
L+AA G++ L+ L++ G+ + D G+ V+ A R GH+D +KFL
Sbjct: 384 LIAAGCGNIQILQLLIKRGSR-IDVQDKGGSNAVYWAARHGHVDTLKFL----------- 431
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
E C L +D SG LH+AAR+GH + + L
Sbjct: 432 ------------------------SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF 467
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
G + ++ +E PLH AA G + K L A G +VN + R G +PL A G+ +
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA-GCNVNIKNREGETPLLTASARGYHDI 526
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVT---FTDIGLTARDNEGATAL 243
+ L + GAD++ DG ALH A R ++ L++ F D +D G T L
Sbjct: 527 VECLAEH-GADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY----QDRHGNTPL 581
Query: 244 HFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDE 302
H A + G+ PI+ L + + + +G TPLH AA NG ++ + L
Sbjct: 582 HVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTT 641
Query: 303 DGYTAADLAEYHGHRDCAQYL 323
DG TA DLA H A L
Sbjct: 642 DGKTAEDLARSEQHEHVAGLL 662
Score = 97.4 bits (241), Expect = 6e-20
Identities = 79/273 (28%), Positives = 130/273 (47%), Gaps = 5/273 (1%)
Query: 64 NQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWL 123
NQ +G P AA G++ L L++ G + QD G + ++ AAR GH +++L
Sbjct: 373 NQPNKHGTPPLLIAAGCGNIQILQLLIKRGS-RIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 124 LHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGH 183
++ + G LH AA G +LL + GS+ N + + +PL+ A G+
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLL-CSFGSNPNIQDKEEETPLHCAAWHGY 490
Query: 184 LHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATAL 243
+A+ L + G +V+++ +G + L A+ARG++ +V L L A D +G AL
Sbjct: 491 YSVAKALC-EAGCNVNIKNREGETPLLTASARGYHDIVECLAEH-GADLNACDKDGHIAL 548
Query: 244 HFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDE 302
H A R ++ LL G + +D G TPLH A ++G M L + + + ++
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNK 608
Query: 303 DGYTAADLAEYHGHRDCAQYLREVAQPVPLLMT 335
G T LA +G D +YL + V L T
Sbjct: 609 YGRTPLHLAANNGILDVVRYLCLMGASVEALTT 641
Score = 72.4 bits (176), Expect = 2e-12
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 3/172 (1%)
Query: 155 LLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAA 214
LL + VN+ + G PL +A G++ + Q L+K G+ + ++ G +A++ AA
Sbjct: 363 LLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKR-GSRIDVQDKGGSNAVYWAAR 421
Query: 215 RGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGT-PILRDSWGGT 273
GH + +L + L +D G ALH AAR GH + L G+ P ++D T
Sbjct: 422 HGHVDTLKFL-SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET 480
Query: 274 PLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLRE 325
PLH AA +G + L + ++++ +G T A G+ D + L E
Sbjct: 481 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAE 532
Score = 51.6 bits (122), Expect = 4e-06
Identities = 54/185 (29%), Positives = 83/185 (44%), Gaps = 6/185 (3%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQLPGNQRA 67
AA G + + L EAG I + G + A+ G+ D V+ L + A L N
Sbjct: 485 AAWHGYYSVAKALCEAGC-NVNIKNREGETPLLTASARGYHDIVECLAEHGADL--NACD 541
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
+G H A + + L+ +G C + QD G +PLH+A + G+ +V L
Sbjct: 542 KDGHIALHLAVRRCQMEVIKTLLSQG-CFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600
Query: 128 HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLA 187
+ + + G PLH AA +G L ++ L G+SV T G + LA E H H+A
Sbjct: 601 CNLDISNKYGRTPLHLAANNGILDVVRYLCLM-GASVEALTTDGKTAEDLARSEQHEHVA 659
Query: 188 QFLVK 192
L +
Sbjct: 660 GLLAR 664
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 113 bits (283), Expect = 8e-25
Identities = 102/337 (30%), Positives = 149/337 (44%), Gaps = 59/337 (17%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQLPGNQRA 67
A G + T+ LL GA + D +H A GHL+ +K LV R A L R
Sbjct: 147 AVHSGHLETVNLLLNKGA-SLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK 205
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
G H AAA+G + + +L+R G + + +A G + LH+A G + L++ G
Sbjct: 206 GYGLL--HTAAASGQIEVVKYLLRMGA-EIDEPNAFGNTALHIACYLGQDAVAIELVNAG 262
Query: 128 HSATLETREGARPLHHAAVS-GDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
+ +G PLH AAVS CL+LL +G+ VN +++ G SPL++A G
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELL-VNNGADVNYQSKEGKSPLHMAAIHGRFTR 321
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVT-------------------- 226
+Q L+++ G+++ G + LH AA GH L+ L+T
Sbjct: 322 SQILIQN-GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV 380
Query: 227 ---FTD---------------------------IGLTARDNEGATALHFAARGGHTPILD 256
F+D + DN G T LH AA GG+ L+
Sbjct: 381 LFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLN 440
Query: 257 RLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVS 292
LL G + RD +G TPLH AA NG +C TLV+
Sbjct: 441 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
Score = 113 bits (282), Expect = 1e-24
Identities = 117/406 (28%), Positives = 168/406 (41%), Gaps = 85/406 (20%)
Query: 2 EKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQL 61
E+Q AA G + L+ L+ GA G D G GL+H A +G ++ VK+L++
Sbjct: 173 ERQPLHWAAFLGHLEVLKLLVARGA-DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231
Query: 62 PGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVL-V 120
A G T H A G A LV G Q D G +PLH+AA + L +
Sbjct: 232 IDEPNAF-GNTALHIACYLGQDAVAIELVNAGANVNQPND-KGFTPLHVAAVSTNGALCL 289
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
E L++ G +++EG PLH AA+ G T ++L +GS ++ + G +PL++A +
Sbjct: 290 ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ-NGSEIDCADKFGNTPLHVAAR 348
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGH-------------YSLVVWL--- 224
GH L L+ + GAD R + M LH A G YS+V L
Sbjct: 349 YGHELLISTLMTN-GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNE 407
Query: 225 -VTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR-DSWGGTPL------- 275
V + DN G T LH AA GG+ L+ LL G + R D +G TPL
Sbjct: 408 HVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
Query: 276 ---------------------------------------------HDAAENGQME----- 285
HDA E+ ++
Sbjct: 468 SYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRK 527
Query: 286 ----CCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVA 327
C + L+ + DPSLRD GYTA A +G+R + L E++
Sbjct: 528 EAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573
Score = 97.1 bits (240), Expect = 8e-20
Identities = 106/367 (28%), Positives = 149/367 (40%), Gaps = 47/367 (12%)
Query: 9 AAKDGDVATLERLLEAGALGP--GITDALGAGLVHHATRAGHLDCVKFLVQR------AQ 60
AA G +L L+++G + DA G + A GH+DCV L+++ A
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD 718
Query: 61 LPGNQRAHNGA--------------------------TPAHDAAATGSLAELCWLVREGG 94
L G H GA TP H A+A G A L L+ +
Sbjct: 719 LRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL-QAA 777
Query: 95 CGLQDQDA----SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDL 150
DA SG SP+H A+ GH +E LL + LE PLH A ++
Sbjct: 778 LSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFT-PLHCAVINNQD 836
Query: 151 TCLKLLTAAHGSS-VNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSAL 209
+ ++L A G+ VN R G +PL+ A ++ + L++ A+V+ G +AL
Sbjct: 837 STTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQH-QAEVNATDHTGRTAL 895
Query: 210 HAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTP----ILDRLLLMGTPI 265
AA G + V +L+ LT D TALH A GH IL +G
Sbjct: 896 MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955
Query: 266 LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT-AADLAEYHGHRDCAQYLR 324
+S PLH AA NG Q L+SH DE+G+T A A DC +
Sbjct: 956 ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
Query: 325 EVAQPVP 331
+P P
Sbjct: 1016 STMKPFP 1022
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/313 (30%), Positives = 143/313 (45%), Gaps = 14/313 (4%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
AA GDV L+ LL +GA D L +H A A + V L+ N R
Sbjct: 48 AAYVGDVPILQLLLMSGA-NVNAKDTLWLTPLHRAA-ASRNEKVLGLLLAHSADVNARDK 105
Query: 69 NGATPAHDAAA---TGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
TP H AAA T L L+ L D SG S LH A GH V LL+
Sbjct: 106 LWQTPLHVAAANRATKCAEALAPLLSS----LNVADRSGRSALHHAVHSGHLETVNLLLN 161
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
+G S + ++ +PLH AA G L LKLL A G+ + + R G L+ A G +
Sbjct: 162 KGASLNVCDKKERQPLHWAAFLGHLEVLKLL-VARGADLGCKDRKGYGLLHTAAASGQIE 220
Query: 186 LAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHF 245
+ ++L++ GA++ G +ALH A G ++ + LV + +++G T LH
Sbjct: 221 VVKYLLR-MGAEIDEPNAFGNTALHIACYLGQDAVAIELVN-AGANVNQPNDKGFTPLHV 278
Query: 246 AARGGHTPI-LDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDED 303
AA + + L+ L+ G + + G +PLH AA +G+ Q L+ + + D+
Sbjct: 279 AAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKF 338
Query: 304 GYTAADLAEYHGH 316
G T +A +GH
Sbjct: 339 GNTPLHVAARYGH 351
Score = 92.4 bits (228), Expect = 2e-18
Identities = 94/329 (28%), Positives = 136/329 (41%), Gaps = 22/329 (6%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA +G L+ L E + + D G + AT G +CV+ L +
Sbjct: 591 LAAYNGHCEALKTLAET-LVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649
Query: 68 HNGATPAHDAAATGSLAELCWLVREGG-CGLQD-QDASGVSPLHLAARFGHPVLVEWLLH 125
TP H AAA+G L L+ G + D DA G +PL LA GH V LL
Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
+G +A G LH AV+G CL L H + V R G +P++LA GH
Sbjct: 710 KGSTADAADLRGRTALHRGAVTGCEDCLAALLD-HDAFVLCRDFKGRTPIHLASACGHTA 768
Query: 186 LAQFLVK--------DCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDN 237
+ + L++ D G D G S +H A+ GH + L+ + +
Sbjct: 769 VLRTLLQAALSTDPLDAGVDY-----SGYSPMHWASYTGHEDCLELLLEHSPFSYL--EG 821
Query: 238 EGATALHFAARGGHTPILDRLL-LMGTPIL--RDSWGGTPLHDAAENGQMECCQTLVSHH 294
T LH A + LL +G I+ RD+ G TPLH AA + + L+ H
Sbjct: 822 NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQ 881
Query: 295 VDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
+ + D G TA A +G ++L
Sbjct: 882 AEVNATDHTGRTALMTAAENGQTAAVEFL 910
Score = 87.8 bits (216), Expect = 5e-17
Identities = 91/286 (31%), Positives = 130/286 (45%), Gaps = 16/286 (5%)
Query: 51 CVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDAS-GVSPLH 109
C++FL+ P + R G T H AAA G+ L L+ L+D +++ VSPLH
Sbjct: 532 CLEFLLDNGADP-SLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLH 590
Query: 110 LAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTR 169
LAA GH ++ L + + +G L A G C+++LTA S++ + +
Sbjct: 591 LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650
Query: 170 SGASPLYLACQEGHLHLAQFLVKDCG--ADV-HLRALDGMSALHAAAARGHYSLVVWLVT 226
+PL+ A GH L+ D G AD+ + G + L A GH V L+
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLI-DSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL- 708
Query: 227 FTDIGLT--ARDNEGATALHFAARGGHTPILDRLLLMGTPIL-RDSWGGTPLHDAAENGQ 283
+ G T A D G TALH A G L LL +L RD G TP+H A+ G
Sbjct: 709 --EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766
Query: 284 MECCQTLV--SHHVDP--SLRDEDGYTAADLAEYHGHRDCAQYLRE 325
+TL+ + DP + D GY+ A Y GH DC + L E
Sbjct: 767 TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Score = 80.9 bits (198), Expect = 6e-15
Identities = 77/243 (31%), Positives = 112/243 (46%), Gaps = 9/243 (3%)
Query: 72 TPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSAT 131
TP H AA G + L L+ G + +D ++PLH AA + ++ LL HSA
Sbjct: 43 TPLHAAAYVGDVPILQLLLMSGA-NVNAKDTLWLTPLHRAAASRNEKVLGLLL--AHSAD 99
Query: 132 LETRE--GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQF 189
+ R+ PLH AA + C + L A SS+N RSG S L+ A GHL
Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEAL-APLLSSLNVADRSGRSALHHAVHSGHLETVNL 158
Query: 190 LVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARG 249
L+ GA +++ LH AA GH ++ LV L +D +G LH AA
Sbjct: 159 LLNK-GASLNVCDKKERQPLHWAAFLGHLEVLKLLVA-RGADLGCKDRKGYGLLHTAAAS 216
Query: 250 GHTPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAA 308
G ++ LL MG I +++G T LH A GQ LV+ + + ++ G+T
Sbjct: 217 GQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPL 276
Query: 309 DLA 311
+A
Sbjct: 277 HVA 279
Score = 73.6 bits (179), Expect = 9e-13
Identities = 65/211 (30%), Positives = 96/211 (45%), Gaps = 4/211 (1%)
Query: 106 SPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVN 165
+PLH AA G +++ LL G + + PLH AA S + L LL AH + VN
Sbjct: 43 TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL-LAHSADVN 101
Query: 166 RRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLV 225
R + +PL++A A+ L + +++ G SALH A GH V L+
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALA-PLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 160
Query: 226 TFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQM 284
L D + LH+AA GH +L L+ G + +D G LH AA +GQ+
Sbjct: 161 N-KGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 219
Query: 285 ECCQTLVSHHVDPSLRDEDGYTAADLAEYHG 315
E + L+ + + G TA +A Y G
Sbjct: 220 EVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Score = 69.7 bits (169), Expect = 1e-11
Identities = 61/205 (29%), Positives = 89/205 (43%), Gaps = 4/205 (1%)
Query: 120 VEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
V LL + + + +E PLH AA GD+ L+LL + G++VN + +PL+ A
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMS-GANVNAKDTLWLTPLHRAA 82
Query: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
+ + L+ ADV+ R + LH AAA L L D G
Sbjct: 83 ASRNEKVLGLLLAH-SADVNARDKLWQTPLHVAAANRATKCAEALAPLLS-SLNVADRSG 140
Query: 240 ATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPS 298
+ALH A GH ++ LL G + + D PLH AA G +E + LV+ D
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG 200
Query: 299 LRDEDGYTAADLAEYHGHRDCAQYL 323
+D GY A G + +YL
Sbjct: 201 CKDRKGYGLLHTAAASGQIEVVKYL 225
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 112 bits (280), Expect = 2e-24
Identities = 85/290 (29%), Positives = 132/290 (45%), Gaps = 24/290 (8%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A++AG L+ VK L + +TP H AA ++ + +L+ G + +D
Sbjct: 657 ASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA-DVHAKDK 715
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
G+ PLH A +GH + E L+ G S + PLH AA G KLL HG+
Sbjct: 716 GGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK-HGA 774
Query: 163 SVNRRTRSGASPLYLACQ---------EGHLHLAQFLVKDCGA---------DVHLRALD 204
++ R G +PL L + G L K C A +++ R
Sbjct: 775 DPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQ 834
Query: 205 GMSA--LHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMG 262
G ++ LH AA + + +L+ + A+D G LH AA GH I L+
Sbjct: 835 GRNSTPLHLAAGYNNLEVAEYLLEH-GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN 893
Query: 263 TPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLA 311
T + D W TPLH+AA+ G+ + C L++H DP++++++G T DLA
Sbjct: 894 TCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 109 bits (273), Expect = 1e-23
Identities = 98/315 (31%), Positives = 134/315 (42%), Gaps = 29/315 (9%)
Query: 22 LEAGALGPGITDALGAGLVHH---ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAA 78
L GA GPG +G + A R G + VK LV A + A ++P H AA
Sbjct: 165 LGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAA 224
Query: 79 ATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGA 138
G + L++ G + +D G+ PLH A FGH +V LL +G
Sbjct: 225 GFGRKDVVEHLLQMGA-NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNY 283
Query: 139 RPLHHAAVSGDL-TCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKD---- 193
PLH AA+ G + C+ LL HG+ N R G S L LA L KD
Sbjct: 284 TPLHEAAIKGKIDVCIVLLQ--HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLE 341
Query: 194 --------------CGADVHLRALDGMSA--LHAAAARGHYSLVVWLVTFTDIGLTARDN 237
+V+ A DG + LH AA +V L+ + A+D
Sbjct: 342 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH-GADVHAKDK 400
Query: 238 EGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVD 296
G LH A GH + + LL G + D W TPLH+AA ++E C L+SH D
Sbjct: 401 GGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD 460
Query: 297 PSLRDEDGYTAADLA 311
P+L + G +A D+A
Sbjct: 461 PTLVNCHGKSAVDMA 475
Score = 85.1 bits (209), Expect = 3e-16
Identities = 76/264 (28%), Positives = 118/264 (44%), Gaps = 32/264 (12%)
Query: 89 LVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSG 148
L+ G + +++ ++PLH+AA H ++E L G G LH AA++G
Sbjct: 543 LLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAG 602
Query: 149 DLTCLKLL---------------TAAH-GSSVNRRTRSGASP---------LYLACQEGH 183
L +LL TAA G+ ++ S ++P L A + G
Sbjct: 603 HLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGD 662
Query: 184 LHLAQFLVKDCGADVHLRALDGMSA--LHAAAARGHYSLVVWLVTFTDIGLTARDNEGAT 241
L + L +V+ R L+G + LH AA S+V +L+ + A+D G
Sbjct: 663 LETVKQLCSS--QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLV 719
Query: 242 ALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLR 300
LH A GH + + L+ G + + D W TPLH+AA G+ E C+ L+ H DP+ +
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 301 DEDGYTAADLAEYHGHRDCAQYLR 324
+ DG T DL + G D LR
Sbjct: 780 NRDGNTPLDLVK-EGDTDIQDLLR 802
Score = 79.7 bits (195), Expect = 1e-14
Identities = 49/136 (36%), Positives = 70/136 (51%), Gaps = 2/136 (1%)
Query: 178 ACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDN 237
AC+ G + + LV + A S LH AA G +V L+ + ARD+
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQM-GANVHARDD 247
Query: 238 EGATALHFAARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVD 296
G LH A GH ++ LL G P RD+W TPLH+AA G+++ C L+ H D
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307
Query: 297 PSLRDEDGYTAADLAE 312
P++R+ DG +A DLA+
Sbjct: 308 PNIRNTDGKSALDLAD 323
Score = 53.1 bits (126), Expect = 1e-06
Identities = 39/120 (32%), Positives = 51/120 (42%), Gaps = 2/120 (1%)
Query: 212 AAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSW 270
A G S V LV ++ ++ LHFAA G +++ LL MG + RD
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
Query: 271 GGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRD-CAQYLREVAQP 329
G PLH+A G E L+ DP+ RD YT A G D C L+ A P
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
Score = 35.0 bits (79), Expect = 0.35
Identities = 26/73 (35%), Positives = 29/73 (39%), Gaps = 14/73 (19%)
Query: 307 AADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGRRGGPGPGNP 366
AA H H Q L QP P PPPPP PP L G G P +P
Sbjct: 2 AASRRSQHHHHHHQQQL----QPAPGASAPPPPPPPP---------LSPGLAPGTTPASP 48
Query: 367 SPMSLSP-AWPGH 378
+ L+P A P H
Sbjct: 49 TASGLAPFASPRH 61
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 112 bits (279), Expect = 2e-24
Identities = 107/326 (32%), Positives = 138/326 (42%), Gaps = 35/326 (10%)
Query: 7 LVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQR 66
L A G + +LL GA D G +H A GH V+ L+QR P
Sbjct: 46 LQAVWRGPAGLVTQLLRQGA-SVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA-PVGAV 103
Query: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
G T H+AA G + + L+ + G + +G++PLH AA GH +L LL
Sbjct: 104 DRAGRTALHEAAWHGH-SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Query: 127 GH----SATLETREGARPLHHAAVSGDLTCLKLLTA------------------------ 158
+A E G H AA G L L+LL A
Sbjct: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
Query: 159 -AHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGH 217
A G+ V+ R +GA+ L LA G + L+ GAD +R G SALH AAARGH
Sbjct: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGH-GADPGIRDRHGRSALHRAAARGH 281
Query: 218 YSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSW-GGTPLH 276
V LVT + ARD G T LH A+R GH + LL G + W TPLH
Sbjct: 282 LLAVQLLVT-QGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
Query: 277 DAAENGQMECCQTLVSHHVDPSLRDE 302
AAE G L+S P+LR +
Sbjct: 341 LAAERGHGPTVGLLLSRGASPTLRTQ 366
Score = 90.1 bits (222), Expect = 9e-18
Identities = 79/234 (33%), Positives = 104/234 (44%), Gaps = 13/234 (5%)
Query: 94 GCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCL 153
G ++++D +G +PLHLA GH LV LL G R G LH AA G
Sbjct: 64 GASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVA 123
Query: 154 KLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCG---ADVHLRALDGMSALH 210
+LL G+S R+ +G +PL+ A GH LA L++ G A G +A H
Sbjct: 124 ELL-LQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAH 182
Query: 211 AAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDS 269
AAA G + V+ L+ GL AL AA G L LL G + RD
Sbjct: 183 WAAAGGRLA-VLELLAAGGAGLDG-------ALLVAAAAGRGAALRFLLARGARVDARDG 234
Query: 270 WGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
G T L AA G+ + + L+ H DP +RD G +A A GH Q L
Sbjct: 235 AGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLL 288
Score = 54.3 bits (129), Expect = 6e-07
Identities = 42/130 (32%), Positives = 54/130 (41%), Gaps = 2/130 (1%)
Query: 203 LDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMG 262
+ G L A RG LV L+ + RD+ G T LH A GH P++ LL G
Sbjct: 39 VQGWGHLLQAVWRGPAGLVTQLLR-QGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRG 97
Query: 263 TPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQ 321
P+ D G T LH+AA +G + L+ + R G T A GH A
Sbjct: 98 APVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAA 157
Query: 322 YLREVAQPVP 331
L E P P
Sbjct: 158 RLLEAPGPGP 167
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 109 bits (273), Expect = 1e-23
Identities = 162/574 (28%), Positives = 239/574 (41%), Gaps = 70/574 (12%)
Query: 3 KQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQ 60
K+ AL +A G + + LLEAGA TD + L+ A GH++ + L+ AQ
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME-ACMDGHVEVARLLLDSGAQ 459
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
+ N A + +P AA G EL L+ E G L++ + G +PL AAR GH +V
Sbjct: 460 V--NMPADSFESPL-TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Query: 121 EWLLHEG---HSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYL 177
LL +G ++ T ET+E A L A G L L A G+ + ++PL
Sbjct: 517 ALLLGQGANINAQTEETQETALTL--ACCGGFLEVADFLIKA-GADIELGC---STPLME 570
Query: 178 ACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDN 237
A QEGHL L ++L+ GA+VH G +AL A GH + L+ L
Sbjct: 571 AAQEGHLELVKYLLA-AGANVHATTATGDTALTYACENGHTDVADVLLQ-AGADLEHESE 628
Query: 238 EGATALHFAARGGHTPILDRLLLMGTPILRDSWGG--TPLHDAAENGQMECCQTLVSHHV 295
G T L AAR GH + L+ G + R + T L A G + + L++H
Sbjct: 629 GGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Query: 296 DPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPP--PPFPPPPLLATRRSL 353
DP+ R +DG T A GH YL + P LL PPP PP
Sbjct: 689 DPTHRLKDGSTMLIEAAKGGHTSVVCYLLD--YPNNLLSAPPPDVTQLTPPS-------- 738
Query: 354 EDGRRGGPGPGNPSPMSLSPAWPGHP--------------------DQPLPREQ------ 387
D R P PM + P P P LP
Sbjct: 739 HDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGY 798
Query: 388 MTSPAPPRIITSATADPEGTETAL--AGDTSDGLAALQL---DGLPSGDIDGLVPTRDE- 441
+T+ +P I+ A E + A + + L +L+L D L I+ L TR+E
Sbjct: 799 ITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQ 858
Query: 442 --RGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPTEQAAWRYSQTHQAILGP-- 497
+ Q I E + Q + R+LQ + + + + +Q + Q H +L P
Sbjct: 859 IQKKQKILE-ELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQ-HLGLLTPVG 916
Query: 498 FGELLTEDDLVYLEKQIADLQLRRRCQEYESELG 531
GE L+E D L+ Q+ + L+ Q+ +++G
Sbjct: 917 VGEQLSEGDYARLQ-QVDPVLLKDEPQQTAAQMG 949
Score = 88.2 bits (217), Expect = 4e-17
Identities = 98/329 (29%), Positives = 147/329 (44%), Gaps = 14/329 (4%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+A G ++ LLE GA D G + A AGH+ V+ L+ Q
Sbjct: 1089 LACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 1147
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
TP A +G E+ L+ G + ++ S +PL LAA G+ +++ LL+ G
Sbjct: 1148 RTKDTPL-SLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206
Query: 128 HSATLETREGAR----PLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASP-LYLACQEG 182
A + +R G++ PL AA++G +KLL GS +N + + + L LAC +G
Sbjct: 1207 --AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-GSDINAQIETNRNTALTLACFQG 1263
Query: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVTFTDIGLTARDNEGAT 241
+ L+ D A+V RA G++ L AA+ G+ + V L D+ + T
Sbjct: 1264 RTEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1322
Query: 242 ALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLR 300
AL AA GH + L+ G I +R+ G TPL AA G ++ Q LV D
Sbjct: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1382
Query: 301 DEDGYTAADLAEYHGHRDCAQYL-REVAQ 328
D T A GH +YL +EV Q
Sbjct: 1383 DNRKITPLMAAFRKGHVKVVRYLVKEVNQ 1411
Score = 82.0 bits (201), Expect = 3e-15
Identities = 88/316 (27%), Positives = 133/316 (42%), Gaps = 42/316 (13%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A GH+ VK L+ + N ++ G T A A G ++ ++ E G ++D +
Sbjct: 308 AANGGHVKIVKLLLAH-KADVNAQSSTGNT-ALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEG---HSATLETREGARPLHHAAVSGDLTCLKLLTAA 159
+G +PL A GH + LL G ++ + E +E A L A G L ++ L A
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL--ACYKGHLEMVRFLLEA 423
Query: 160 HGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYS 219
G+ +T + L AC +GH+ +A+ L+ D GA V++ A S L AA GH
Sbjct: 424 -GADQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMG------------TPILR 267
L L+ L ++EG T L AAR GH ++ LL G T +
Sbjct: 482 LAALLIE-RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 268 DSWGG--------------------TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTA 307
GG TPL +AA+ G +E + L++ + G TA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 308 ADLAEYHGHRDCAQYL 323
A +GH D A L
Sbjct: 601 LTYACENGHTDVADVL 616
Score = 80.9 bits (198), Expect = 6e-15
Identities = 87/294 (29%), Positives = 127/294 (43%), Gaps = 10/294 (3%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A GH + V+ L++R R G TP AA G + + L+ G +
Sbjct: 1090 ACAGGHEELVQTLLERGASI-EHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 1148
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
+ +PL LA G +VE LL G + PL AA G + +K+L A G+
Sbjct: 1149 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GA 1207
Query: 163 SVNRRTRS--GASPLYLACQEGHLHLAQFLVKDCGADVHLR-ALDGMSALHAAAARGHYS 219
+N RT S G SPL LA GH + L+ D G+D++ + + +AL A +G +
Sbjct: 1208 EINSRTGSKLGISPLMLAAMNGHTAAVKLLL-DMGSDINAQIETNRNTALTLACFQGR-T 1265
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR---DSWGGTPLH 276
VV L+ + R G T L AA GG+ + LL G + S T L
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
Query: 277 DAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
AA+ G + C+ L+ +R++ G T LA GH D Q L + V
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1379
Score = 80.1 bits (196), Expect = 1e-14
Identities = 82/254 (32%), Positives = 115/254 (45%), Gaps = 18/254 (7%)
Query: 75 HDAAAT----GSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSA 130
HD A T G EL + E G ++ +D G +PL LAA GH +VE LL G
Sbjct: 1083 HDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADI 1142
Query: 131 TLET-REGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQF 189
++ R PL A G ++LL A G++ R S +PL LA G++++ +
Sbjct: 1143 EAQSERTKDTPLSLACSGGRQEVVELL-LARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1201
Query: 190 LVKDCGADVHLRALD--GMSALHAAAARGHYSLVVWLVTF-TDIGLTARDNEGATALHFA 246
L+ + GA+++ R G+S L AA GH + V L+ +DI N TAL A
Sbjct: 1202 LL-NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLA 1259
Query: 247 ARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVD------PSL 299
G T ++ LL + R G TPL +AA G E + L+ D PS
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319
Query: 300 RDEDGYTAADLAEY 313
RD AAD Y
Sbjct: 1320 RDTALTIAADKGHY 1333
Score = 67.0 bits (162), Expect = 8e-11
Identities = 66/250 (26%), Positives = 113/250 (45%), Gaps = 8/250 (3%)
Query: 78 AATGSLAELCWLVREGGCGLQDQDASG-VSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
A + EL ++ ++D+ G ++PL AA GH +V+ LL ++
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196
G L +A G + +K+L + G+S+ +G +PL A GH+ +A+ L+++ GA
Sbjct: 334 GNTALTYACAGGYVDVVKVLLES-GASIEDHNENGHTPLMEAGSAGHVEVARLLLEN-GA 391
Query: 197 DVHLRALD-GMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPIL 255
++ + + SAL A +GH +V +L+ + +E TAL A GH +
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVA 450
Query: 256 DRLLLMGTPI--LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEY 313
LL G + DS+ +PL AA G +E L+ +++GYT A
Sbjct: 451 RLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAR 509
Query: 314 HGHRDCAQYL 323
GH + L
Sbjct: 510 EGHEEMVALL 519
Score = 62.0 bits (149), Expect = 3e-09
Identities = 63/232 (27%), Positives = 100/232 (43%), Gaps = 9/232 (3%)
Query: 108 LHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRR 167
L LA GH LV+ LL G S ++G PL AA +G + +++L +
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146
Query: 168 TRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVT 226
R+ +PL LAC G + + L+ GA+ R + + L AA+ G+ +++ + L
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
Query: 227 FTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR--DSWGGTPLHDAAENGQM 284
+I G + L AA GHT + LL MG+ I ++ T L A G+
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
Query: 285 ECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV-----AQPVP 331
E L+ + R + G T A G+ + + L + A PVP
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1317
Score = 60.5 bits (145), Expect = 8e-09
Identities = 63/231 (27%), Positives = 98/231 (42%), Gaps = 8/231 (3%)
Query: 120 VEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
V LL EG S T EG L A +G ++L A H + +R + +PL A
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
Query: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
GH+ + + L+ ADV+ ++ G +AL A A G+ +V L+ + + + G
Sbjct: 310 NGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGGYVDVVKVLLE-SGASIEDHNENG 367
Query: 240 ATALHFAARGGHTPILDRLLLMGTPILRDS--WGGTPLHDAAENGQMECCQTLVSHHVDP 297
T L A GH + LL G I S + + L A G +E + L+ D
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Query: 298 SLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLA 348
+ ++ +TA A GH + A+ L + V + P F P LA
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLA 474
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 107 bits (266), Expect = 7e-23
Identities = 96/349 (27%), Positives = 144/349 (41%), Gaps = 32/349 (9%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A +AG ++ VK L + +TP H AA ++ + +L++ G + +D
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGA-DVHAKDK 557
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
G+ PLH A +GH + E L+ G + PLH AA G KLL HG+
Sbjct: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQ-HGA 616
Query: 163 SVNRRTRSGASPLYLACQ---------EGHLHLAQFLVKDCGA---------DVHLRALD 204
++ R G +PL L G L K C A +V+ R
Sbjct: 617 DPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQ 676
Query: 205 GMSA--LHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMG 262
G + LH AA + + +L+ + A+D G LH AA GH + L+
Sbjct: 677 GRHSTPLHLAAGYNNLEVAEYLLQH-GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 263 TPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQ 321
+ D W TPLH+AA+ G+ + C L++H DP+L++++G T DL D
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS----ADDVS 791
Query: 322 YLREVAQPVPLLMTPPPPPFPPPPLLATRRSLEDGRRGGPGPGNPSPMS 370
L A P L P + P L R GP +PS +S
Sbjct: 792 ALLTAAMPPSAL----PSCYKPQVLNGVRSPGATADALSSGPSSPSSLS 836
Score = 99.8 bits (247), Expect = 1e-20
Identities = 87/291 (29%), Positives = 124/291 (42%), Gaps = 26/291 (8%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A R G ++ VK LV ++ A +TP H AA G + +L+ + G +Q +D
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-QNGANVQARDD 89
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDL-TCLKLLTAAHG 161
G+ PLH A FGH +V LL G PLH AA+ G + C+ LL HG
Sbjct: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLL--QHG 147
Query: 162 SSVNRRTRSGASPLYLACQEGHLHLAQFLVKD------------------CGADVHLRAL 203
+ R G + L LA L KD +V+ A
Sbjct: 148 AEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHAS 207
Query: 204 DGMSA--LHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLM 261
DG + LH AA +V L+ + A+D LH A GH + + L+
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQH-GADVHAKDKGDLVPLHNACSYGHYEVTELLVKH 266
Query: 262 GTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLA 311
G + D W TPLH+AA ++E C L+S+ DP+L + +A DLA
Sbjct: 267 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 88.2 bits (217), Expect = 4e-17
Identities = 84/295 (28%), Positives = 137/295 (46%), Gaps = 29/295 (9%)
Query: 4 QRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPG 63
++ L AAK GDV T+++L ++ + + +H A + V++L+Q
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG-ADV 552
Query: 64 NQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWL 123
+ + G P H+A + G E+ L+ + G + D +PLH AA G + + L
Sbjct: 553 HAKDKGGLVPLHNACSYGHY-EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Query: 124 LHEGHSATLETREGARPLH--------------------HAAVSGDLTCLKLLTAAHGSS 163
L G T + R+G PL AA G L +K L++ +
Sbjct: 612 LQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP--DN 669
Query: 164 VNRRTRSG--ASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV 221
VN R G ++PL+LA +L +A++L++ GADV+ + G+ LH AA+ GH +
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH-GADVNAQDKGGLIPLHNAASYGHVDVA 728
Query: 222 VWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGT-PILRDSWGGTPL 275
L+ + + + A D T LH AA+ G T + LL G P L++ G TPL
Sbjct: 729 ALLIKY-NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 83.6 bits (205), Expect = 9e-16
Identities = 79/287 (27%), Positives = 125/287 (43%), Gaps = 42/287 (14%)
Query: 72 TPAHDAAATG--SLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLL-HEGH 128
T H AAA+ ++C L+ G + ++ ++PLH+A+ H +VE ++ HE
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQ 188
L+ G LH AA G L +LL ++G N + G + A Q G+ ++ Q
Sbjct: 426 VNALDNL-GQTSLHRAAYCGHLQTCRLL-LSYGCDPNIISLQG----FTALQMGNENVQQ 479
Query: 189 FLVKDCG----------------------------ADVHLRALDGMSA--LHAAAARGHY 218
L + V+ R ++G + LH AA
Sbjct: 480 LLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV 539
Query: 219 SLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHD 277
S+V +L+ + A+D G LH A GH + + L+ G + + D W TPLH+
Sbjct: 540 SVVEYLLQH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598
Query: 278 AAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLR 324
AA G+ E C+ L+ H DP+ ++ DG T DL + G D LR
Sbjct: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK-DGDTDIQDLLR 644
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/156 (33%), Positives = 79/156 (50%), Gaps = 2/156 (1%)
Query: 158 AAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGH 217
AA S+ A L+ AC+ G + + LV + A + LH AA G
Sbjct: 11 AACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGR 70
Query: 218 YSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGT-PILRDSWGGTPLH 276
+V +L+ + ARD+ G LH A GH +++ LL G P RD+W TPLH
Sbjct: 71 KDVVEYLLQ-NGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH 129
Query: 277 DAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAE 312
+AA G+++ C L+ H +P++R+ DG TA DLA+
Sbjct: 130 EAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Score = 59.3 bits (142), Expect = 2e-08
Identities = 72/303 (23%), Positives = 121/303 (39%), Gaps = 41/303 (13%)
Query: 53 KFLVQRAQLPGNQRAHNG--ATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHL 110
K + L N A +G +TP H AA + ++ L+ + G + +D + PLH
Sbjct: 192 KMMALLTPLNVNCHASDGRKSTPLHLAAGYNRV-KIVQLLLQHGADVHAKDKGDLVPLHN 250
Query: 111 AARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTA--AHGSSVNRRT 168
A +GH + E L+ G PLH AA + LL + A + +N
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310
Query: 169 RSGAS------------------PLYLACQEGHL-----HLAQFLVKDCGADVHLRALDG 205
+S L A +E + HL+ +V H
Sbjct: 311 KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH------ 364
Query: 206 MSALHAAAARGH--YSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGT 263
+ALH AAA + + L+ + + E T LH A+ H +++ ++
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424
Query: 264 PI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQY 322
+ D+ G T LH AA G ++ C+ L+S+ DP++ G+TA + G+ + Q
Sbjct: 425 KVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQL 480
Query: 323 LRE 325
L+E
Sbjct: 481 LQE 483
Score = 54.7 bits (130), Expect = 4e-07
Identities = 44/125 (35%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 209 LHAAAARGHYSLVVWLVTFTDIGLTARDNEG--ATALHFAARGGHTPILDRLLLMGTPI- 265
L A G V LVT + +RD G +T LHFAA G +++ LL G +
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVN--SRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85
Query: 266 LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRD-CAQYLR 324
RD G PLH+A G E L+ H DP+ RD YT A G D C L+
Sbjct: 86 ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 145
Query: 325 EVAQP 329
A+P
Sbjct: 146 HGAEP 150
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 105 bits (263), Expect = 2e-22
Identities = 127/439 (28%), Positives = 171/439 (38%), Gaps = 59/439 (13%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
A G V LLE GA ++ + A GHL+ V+FL++ A +
Sbjct: 374 AGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE-AGADQEHKTD 432
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
T +A G + E+ L+ + G + S SPL LAA GH L L+ G
Sbjct: 433 EMHTALMEACMDGHV-EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 491
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRT-RSGASPLYLACQEGHLHLA 187
S EG PL AA G + LL G+++N +T + + L LAC G L +A
Sbjct: 492 SLEEVNDEGYTPLMEAAREGHEEMVALL-LGQGANINAQTEETQETALTLACCGGFLEVA 550
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAA 247
FL+K GAD+ L + L AA GH LV +L+ + A G TAL +A
Sbjct: 551 DFLIK-AGADIELGC---STPLMEAAQEGHLELVKYLLA-AGANVHATTATGDTALTYAC 605
Query: 248 RGGHTPILDRLLLMGTPILRDSWGG-TPLHDAAENGQMECCQTLVS-------------- 292
GHT + D LL G + +S GG TPL AA G + Q L+S
Sbjct: 606 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDH 665
Query: 293 --------------------HHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPL 332
H DP+ R +DG T A GH YL + P L
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD--YPNNL 723
Query: 333 LMTPPP--PPFPPPPLLATRRSLEDGRRGGPGPGNPSPMSLSPAWPGHPDQPLPREQMTS 390
L PPP PP D R P PM + P PD+P T
Sbjct: 724 LSAPPPDVTQLTPPS--------HDLNRAPRVPVQALPMVVPPQ---EPDKPPANVATTL 772
Query: 391 PAPPRIITSATADPEGTET 409
P + ++ + T T
Sbjct: 773 PIRNKAVSGRASAMSNTPT 791
Score = 88.2 bits (217), Expect = 4e-17
Identities = 98/329 (29%), Positives = 147/329 (44%), Gaps = 14/329 (4%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+A G ++ LLE GA D G + A AGH+ V+ L+ Q
Sbjct: 838 LACAGGHEELVQTLLERGA-SIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 896
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEG 127
TP A +G E+ L+ G + ++ S +PL LAA G+ +++ LL+ G
Sbjct: 897 RTKDTPL-SLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955
Query: 128 HSATLETREGAR----PLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASP-LYLACQEG 182
A + +R G++ PL AA++G +KLL GS +N + + + L LAC +G
Sbjct: 956 --AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-GSDINAQIETNRNTALTLACFQG 1012
Query: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVTFTDIGLTARDNEGAT 241
+ L+ D A+V RA G++ L AA+ G+ + V L D+ + T
Sbjct: 1013 RTEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1071
Query: 242 ALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLR 300
AL AA GH + L+ G I +R+ G TPL AA G ++ Q LV D
Sbjct: 1072 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1131
Query: 301 DEDGYTAADLAEYHGHRDCAQYL-REVAQ 328
D T A GH +YL +EV Q
Sbjct: 1132 DNRKITPLMAAFRKGHVKVVRYLVKEVNQ 1160
Score = 82.0 bits (201), Expect = 3e-15
Identities = 88/316 (27%), Positives = 133/316 (42%), Gaps = 42/316 (13%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A GH+ VK L+ + N ++ G T A A G ++ ++ E G ++D +
Sbjct: 308 AANGGHVKIVKLLLAH-KADVNAQSSTGNT-ALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEG---HSATLETREGARPLHHAAVSGDLTCLKLLTAA 159
+G +PL A GH + LL G ++ + E +E A L A G L ++ L A
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL--ACYKGHLEMVRFLLEA 423
Query: 160 HGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYS 219
G+ +T + L AC +GH+ +A+ L+ D GA V++ A S L AA GH
Sbjct: 424 -GADQEHKTDEMHTALMEACMDGHVEVARLLL-DSGAQVNMPADSFESPLTLAACGGHVE 481
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMG------------TPILR 267
L L+ L ++EG T L AAR GH ++ LL G T +
Sbjct: 482 LAALLIE-RGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Query: 268 DSWGG--------------------TPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTA 307
GG TPL +AA+ G +E + L++ + G TA
Sbjct: 541 ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA 600
Query: 308 ADLAEYHGHRDCAQYL 323
A +GH D A L
Sbjct: 601 LTYACENGHTDVADVL 616
Score = 80.9 bits (198), Expect = 6e-15
Identities = 87/294 (29%), Positives = 127/294 (43%), Gaps = 10/294 (3%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A GH + V+ L++R R G TP AA G + + L+ G +
Sbjct: 839 ACAGGHEELVQTLLERGASI-EHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSER 897
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
+ +PL LA G +VE LL G + PL AA G + +K+L A G+
Sbjct: 898 TKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GA 956
Query: 163 SVNRRTRS--GASPLYLACQEGHLHLAQFLVKDCGADVHLR-ALDGMSALHAAAARGHYS 219
+N RT S G SPL LA GH + L+ D G+D++ + + +AL A +G +
Sbjct: 957 EINSRTGSKLGISPLMLAAMNGHTAAVKLLL-DMGSDINAQIETNRNTALTLACFQGR-T 1014
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR---DSWGGTPLH 276
VV L+ + R G T L AA GG+ + LL G + S T L
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
Query: 277 DAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
AA+ G + C+ L+ +R++ G T LA GH D Q L + V
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADV 1128
Score = 80.1 bits (196), Expect = 1e-14
Identities = 82/254 (32%), Positives = 115/254 (45%), Gaps = 18/254 (7%)
Query: 75 HDAAAT----GSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSA 130
HD A T G EL + E G ++ +D G +PL LAA GH +VE LL G
Sbjct: 832 HDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADI 891
Query: 131 TLET-REGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQF 189
++ R PL A G ++LL A G++ R S +PL LA G++++ +
Sbjct: 892 EAQSERTKDTPLSLACSGGRQEVVELL-LARGANKEHRNVSDYTPLSLAASGGYVNIIKI 950
Query: 190 LVKDCGADVHLRALD--GMSALHAAAARGHYSLVVWLVTF-TDIGLTARDNEGATALHFA 246
L+ + GA+++ R G+S L AA GH + V L+ +DI N TAL A
Sbjct: 951 LL-NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTLA 1008
Query: 247 ARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVD------PSL 299
G T ++ LL + R G TPL +AA G E + L+ D PS
Sbjct: 1009 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1068
Query: 300 RDEDGYTAADLAEY 313
RD AAD Y
Sbjct: 1069 RDTALTIAADKGHY 1082
Score = 67.0 bits (162), Expect = 8e-11
Identities = 66/250 (26%), Positives = 113/250 (45%), Gaps = 8/250 (3%)
Query: 78 AATGSLAELCWLVREGGCGLQDQDASG-VSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
A + EL ++ ++D+ G ++PL AA GH +V+ LL ++
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGA 196
G L +A G + +K+L + G+S+ +G +PL A GH+ +A+ L+++ GA
Sbjct: 334 GNTALTYACAGGYVDVVKVLLES-GASIEDHNENGHTPLMEAGSAGHVEVARLLLEN-GA 391
Query: 197 DVHLRALD-GMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPIL 255
++ + + SAL A +GH +V +L+ + +E TAL A GH +
Sbjct: 392 GINTHSNEFKESALTLACYKGHLEMVRFLLE-AGADQEHKTDEMHTALMEACMDGHVEVA 450
Query: 256 DRLLLMGTPI--LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEY 313
LL G + DS+ +PL AA G +E L+ +++GYT A
Sbjct: 451 RLLLDSGAQVNMPADSF-ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAR 509
Query: 314 HGHRDCAQYL 323
GH + L
Sbjct: 510 EGHEEMVALL 519
Score = 62.0 bits (149), Expect = 3e-09
Identities = 63/232 (27%), Positives = 100/232 (43%), Gaps = 9/232 (3%)
Query: 108 LHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRR 167
L LA GH LV+ LL G S ++G PL AA +G + +++L +
Sbjct: 836 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 895
Query: 168 TRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVT 226
R+ +PL LAC G + + L+ GA+ R + + L AA+ G+ +++ + L
Sbjct: 896 ERTKDTPLSLACSGGRQEVVELLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
Query: 227 FTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR--DSWGGTPLHDAAENGQM 284
+I G + L AA GHT + LL MG+ I ++ T L A G+
Sbjct: 955 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
Query: 285 ECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV-----AQPVP 331
E L+ + R + G T A G+ + + L + A PVP
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1066
Score = 60.5 bits (145), Expect = 8e-09
Identities = 63/231 (27%), Positives = 98/231 (42%), Gaps = 8/231 (3%)
Query: 120 VEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
V LL EG S T EG L A +G ++L A H + +R + +PL A
Sbjct: 250 VRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAA 309
Query: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
GH+ + + L+ ADV+ ++ G +AL A A G+ +V L+ + + + G
Sbjct: 310 NGGHVKIVKLLLAH-KADVNAQSSTGNTALTYACAGGYVDVVKVLLE-SGASIEDHNENG 367
Query: 240 ATALHFAARGGHTPILDRLLLMGTPILRDS--WGGTPLHDAAENGQMECCQTLVSHHVDP 297
T L A GH + LL G I S + + L A G +E + L+ D
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQ 427
Query: 298 SLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLA 348
+ ++ +TA A GH + A+ L + V + P F P LA
Sbjct: 428 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLA 474
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 105 bits (262), Expect = 2e-22
Identities = 94/300 (31%), Positives = 141/300 (47%), Gaps = 13/300 (4%)
Query: 38 GLVHHATRAGHLDCVKFLVQRAQL--PGNQRAH---NGATPAHDAAATGSLAELCWLVRE 92
G +H A RAG + + +V L G H G T +H AA G A + L+
Sbjct: 28 GSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMN 87
Query: 93 GGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTC 152
G L QD G +PLHLAA GH ++ +L G ++ + RP+H+AA G L C
Sbjct: 88 GA-NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGC 146
Query: 153 LKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLV-KDCGADVHLRAL--DGMSAL 209
L+LL G S+ +G P++LA EGHLH +FLV + A L+A +G + L
Sbjct: 147 LQLL-VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
Query: 210 HAAAARGHYSLVVWLVTFTDIGLTARDNEG-ATALHFAARGGHTPILDRLLLMGTPIL-- 266
A +++ ++ G D E A H AA G +L +L+ G +
Sbjct: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
Query: 267 RDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV 326
R G TP+H AA G +EC Q L+ D ++ ++ G +D+A+ H + L E+
Sbjct: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLLEEL 325
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 8/219 (3%)
Query: 8 VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRA 67
+AA G TL+ +L +G + P +TD VH+A G L C++ LV+
Sbjct: 104 LAATHGHSFTLQIMLRSG-VDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWG-CSIEDVD 161
Query: 68 HNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA---SGVSPLHLAARFGHPVLVEWLL 124
+NG P H AA G L +LV Q A +G + L LA RF +++++
Sbjct: 162 YNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFIQ 221
Query: 125 -HEGHSATLETREG-ARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEG 182
E LE +E A P H AA GDL LK L ++N R +G++P++ A +G
Sbjct: 222 GAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQG 281
Query: 183 HLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV 221
H+ Q+L+K GAD ++ G A H + V
Sbjct: 282 HIECLQWLIK-MGADSNITNKAGERPSDVAKRFAHLAAV 319
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 103 bits (258), Expect = 6e-22
Identities = 103/346 (29%), Positives = 152/346 (43%), Gaps = 13/346 (3%)
Query: 3 KQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQ 60
K+ AL +A G + + LLEAGA TD + L+ A GH++ + L+ AQ
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME-ACMDGHVEVARLLLDSGAQ 430
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
+ N A + +P AA G EL L+ E G L++ + G +PL AAR GH +V
Sbjct: 431 V--NMPADSFESPL-TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
LL +G + +T E A G + + G+ + ++PL A Q
Sbjct: 488 ALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEASQ 544
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
EGHL L ++L+ GA+VH G +AL A GH + L+ L G
Sbjct: 545 EGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQ-AGADLEHESEGGR 602
Query: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGG--TPLHDAAENGQMECCQTLVSHHVDPS 298
T L AAR GH + L+ G + R + T + A G + + L++H DP+
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 299 LRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPP 344
R +DG T A GH + YL + V + T PPP
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPP 708
Score = 86.7 bits (213), Expect = 1e-16
Identities = 89/294 (30%), Positives = 135/294 (45%), Gaps = 13/294 (4%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A AGH+ V+ L+ + Q TP A +G E+ L+ G + ++
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPL-SLACSGGRQEVVDLLLARGANKEHRNV 1153
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGAR----PLHHAAVSGDLTCLKLLTA 158
S +PL LAA G+ +++ LL+ G A + +R G++ PL AA++G + +KLL
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAG--AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
Query: 159 AHGSSVNRRTRSGASP-LYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGH 217
GS +N + + + L LAC +G + L+ D A+V RA G++ L AA+ G+
Sbjct: 1212 M-GSDINAQIETNRNTALTLACFQGRAEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGY 1269
Query: 218 YSLV-VWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPL 275
+ V L D+ + TAL AA GH + L+ G I +R+ G TPL
Sbjct: 1270 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1329
Query: 276 HDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL-REVAQ 328
A+ G + Q LV D D T A GH QYL +EV Q
Sbjct: 1330 WLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/333 (27%), Positives = 149/333 (44%), Gaps = 10/333 (3%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
A DGDV + +LL+ G T+ G L+ A AG+ + + L+ R +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAM-HANVEDRGN 269
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
G AA++G ++ L+ + Q A+G + L A G +V+ LL+EG
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 329
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRS-GASPLYLACQEGHLHLA 187
+ G PL AA +G + ++L HG+ +N + S L LAC +GHL +
Sbjct: 330 NIEDHNENGHTPLMEAASAGHVEVARVL-LDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVTFTDIGLTARDNEGATALHFA 246
+FL+ + GAD + + +AL A GH + + L + + + A E + L A
Sbjct: 389 RFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE--SPLTLA 445
Query: 247 ARGGHTPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
A GGH + L+ G + + G TPL +AA G E L++ + + + E+
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Query: 306 -TAADLAEYHGHRDCAQYLREVAQPVPLLMTPP 337
TA LA G + A +L + + L + P
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCSTP 538
Score = 82.4 bits (202), Expect = 2e-15
Identities = 87/294 (29%), Positives = 128/294 (43%), Gaps = 10/294 (3%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A GH + V L+ R R G TP AA G + + L+ +GG +
Sbjct: 1062 ACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSER 1120
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
+ +PL LA G +V+ LL G + PL AA G + +K+L A G+
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GA 1179
Query: 163 SVNRRTRS--GASPLYLACQEGHLHLAQFLVKDCGADVHLR-ALDGMSALHAAAARGHYS 219
+N RT S G SPL LA GH+ + L+ D G+D++ + + +AL A +G +
Sbjct: 1180 EINSRTGSKLGISPLMLAAMNGHVPAVKLLL-DMGSDINAQIETNRNTALTLACFQGR-A 1237
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR---DSWGGTPLH 276
VV L+ + R G T L AA GG+ + LL G + S T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 277 DAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
AA+ G + C+ L+ +R++ G T LA GH D Q L + V
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Score = 58.5 bits (140), Expect = 3e-08
Identities = 63/231 (27%), Positives = 97/231 (41%), Gaps = 8/231 (3%)
Query: 120 VEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
V LL EG S T EG L A +G ++L A H + +R + +PL A
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
Query: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
G+L + + L+ ADV+ ++ G +AL A A G +V L+ + + G
Sbjct: 281 SGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENG 338
Query: 240 ATALHFAARGGHTPILDRLLLMGTPILRDS--WGGTPLHDAAENGQMECCQTLVSHHVDP 297
T L AA GH + LL G I S + + L A G ++ + L+ D
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
Query: 298 SLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLA 348
+ ++ +TA A GH + A+ L + V + P F P LA
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLA 445
Score = 58.2 bits (139), Expect = 4e-08
Identities = 61/232 (26%), Positives = 97/232 (41%), Gaps = 9/232 (3%)
Query: 108 LHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRR 167
L LA GH LV L+ ++G PL AA +G + +++L G +
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
Query: 168 TRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVT 226
R+ +PL LAC G + L+ GA+ R + + L AA+ G+ +++ + L
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 227 FTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR--DSWGGTPLHDAAENGQM 284
+I G + L AA GH P + LL MG+ I ++ T L A G+
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 285 ECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV-----AQPVP 331
E L+ + R + G T A G+ + + L + A PVP
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 103 bits (258), Expect = 6e-22
Identities = 103/346 (29%), Positives = 152/346 (43%), Gaps = 13/346 (3%)
Query: 3 KQRAL-VAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQR-AQ 60
K+ AL +A G + + LLEAGA TD + L+ A GH++ + L+ AQ
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME-ACMDGHVEVARLLLDSGAQ 430
Query: 61 LPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLV 120
+ N A + +P AA G EL L+ E G L++ + G +PL AAR GH +V
Sbjct: 431 V--NMPADSFESPL-TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMV 487
Query: 121 EWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
LL +G + +T E A G + + G+ + ++PL A Q
Sbjct: 488 ALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGC---STPLMEASQ 544
Query: 181 EGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGA 240
EGHL L ++L+ GA+VH G +AL A GH + L+ L G
Sbjct: 545 EGHLELVKYLLAS-GANVHATTATGDTALTYACENGHTDVADVLLQ-AGADLEHESEGGR 602
Query: 241 TALHFAARGGHTPILDRLLLMGTPILRDSWGG--TPLHDAAENGQMECCQTLVSHHVDPS 298
T L AAR GH + L+ G + R + T + A G + + L++H DP+
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 299 LRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPP 344
R +DG T A GH + YL + V + T PPP
Sbjct: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPP 708
Score = 86.7 bits (213), Expect = 1e-16
Identities = 89/294 (30%), Positives = 135/294 (45%), Gaps = 13/294 (4%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A AGH+ V+ L+ + Q TP A +G E+ L+ G + ++
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPL-SLACSGGRQEVVDLLLARGANKEHRNV 1153
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGAR----PLHHAAVSGDLTCLKLLTA 158
S +PL LAA G+ +++ LL+ G A + +R G++ PL AA++G + +KLL
Sbjct: 1154 SDYTPLSLAASGGYVNIIKILLNAG--AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
Query: 159 AHGSSVNRRTRSGASP-LYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGH 217
GS +N + + + L LAC +G + L+ D A+V RA G++ L AA+ G+
Sbjct: 1212 M-GSDINAQIETNRNTALTLACFQGRAEVVSLLL-DRKANVEHRAKTGLTPLMEAASGGY 1269
Query: 218 YSLV-VWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPL 275
+ V L D+ + TAL AA GH + L+ G I +R+ G TPL
Sbjct: 1270 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1329
Query: 276 HDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL-REVAQ 328
A+ G + Q LV D D T A GH QYL +EV Q
Sbjct: 1330 WLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQ 1383
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/333 (27%), Positives = 149/333 (44%), Gaps = 10/333 (3%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
A DGDV + +LL+ G T+ G L+ A AG+ + + L+ R +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAM-HANVEDRGN 269
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
G AA++G ++ L+ + Q A+G + L A G +V+ LL+EG
Sbjct: 270 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 329
Query: 129 SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRS-GASPLYLACQEGHLHLA 187
+ G PL AA +G + ++L HG+ +N + S L LAC +GHL +
Sbjct: 330 NIEDHNENGHTPLMEAASAGHVEVARVL-LDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 188 QFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVTFTDIGLTARDNEGATALHFA 246
+FL+ + GAD + + +AL A GH + + L + + + A E + L A
Sbjct: 389 RFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE--SPLTLA 445
Query: 247 ARGGHTPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
A GGH + L+ G + + G TPL +AA G E L++ + + + E+
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
Query: 306 -TAADLAEYHGHRDCAQYLREVAQPVPLLMTPP 337
TA LA G + A +L + + L + P
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIELGCSTP 538
Score = 82.4 bits (202), Expect = 2e-15
Identities = 87/294 (29%), Positives = 128/294 (43%), Gaps = 10/294 (3%)
Query: 43 ATRAGHLDCVKFLVQRAQLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDA 102
A GH + V L+ R R G TP AA G + + L+ +GG +
Sbjct: 1062 ACAGGHEELVSVLIAR-DAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSER 1120
Query: 103 SGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGS 162
+ +PL LA G +V+ LL G + PL AA G + +K+L A G+
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GA 1179
Query: 163 SVNRRTRS--GASPLYLACQEGHLHLAQFLVKDCGADVHLR-ALDGMSALHAAAARGHYS 219
+N RT S G SPL LA GH+ + L+ D G+D++ + + +AL A +G +
Sbjct: 1180 EINSRTGSKLGISPLMLAAMNGHVPAVKLLL-DMGSDINAQIETNRNTALTLACFQGR-A 1237
Query: 220 LVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR---DSWGGTPLH 276
VV L+ + R G T L AA GG+ + LL G + S T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 277 DAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPV 330
AA+ G + C+ L+ +R++ G T LA GH D Q L + V
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Score = 58.5 bits (140), Expect = 3e-08
Identities = 63/231 (27%), Positives = 97/231 (41%), Gaps = 8/231 (3%)
Query: 120 VEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
V LL EG S T EG L A +G ++L A H + +R + +PL A
Sbjct: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
Query: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEG 239
G+L + + L+ ADV+ ++ G +AL A A G +V L+ + + G
Sbjct: 281 SGGYLDIVKLLLLH-DADVNSQSATGNTALTYACAGGFVDIVKVLLN-EGANIEDHNENG 338
Query: 240 ATALHFAARGGHTPILDRLLLMGTPILRDS--WGGTPLHDAAENGQMECCQTLVSHHVDP 297
T L AA GH + LL G I S + + L A G ++ + L+ D
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
Query: 298 SLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLA 348
+ ++ +TA A GH + A+ L + V + P F P LA
Sbjct: 399 EHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM----PADSFESPLTLA 445
Score = 58.2 bits (139), Expect = 4e-08
Identities = 61/232 (26%), Positives = 97/232 (41%), Gaps = 9/232 (3%)
Query: 108 LHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRR 167
L LA GH LV L+ ++G PL AA +G + +++L G +
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
Query: 168 TRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLV-VWLVT 226
R+ +PL LAC G + L+ GA+ R + + L AA+ G+ +++ + L
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLAR-GANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 227 FTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR--DSWGGTPLHDAAENGQM 284
+I G + L AA GH P + LL MG+ I ++ T L A G+
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 285 ECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREV-----AQPVP 331
E L+ + R + G T A G+ + + L + A PVP
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 102 bits (255), Expect = 1e-21
Identities = 93/306 (30%), Positives = 136/306 (44%), Gaps = 14/306 (4%)
Query: 30 GITDALGAGLVHHATRAGHLD-----CVKFLVQRAQLPG--NQRAHNGATPAHDAAATGS 82
GI D G +H A A H D V+ ++ A N + + G TP H A A G+
Sbjct: 176 GIPDVEGKIPLHWA--ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGN 233
Query: 83 LAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLET-REGARPL 141
+ + L C + D +PLH AA GH +V LL S T+ + +GA PL
Sbjct: 234 VTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPL 293
Query: 142 HHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH-LAQFLVKDCGADVHL 200
H+AA S +K+ H S + G + A +G L L D+++
Sbjct: 294 HYAAQSNFAETVKVF-LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 352
Query: 201 RALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLL 260
G +ALHAAA GH S V L+ + + A D T L A GH ++ L+
Sbjct: 353 ADKYGGTALHAAALSGHVSTVKLLLE-NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
Query: 261 MGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDC 319
G + L D G + LH AA G + CQ L+ + ++P+++D G T A Y G+ +C
Sbjct: 412 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINC 471
Query: 320 AQYLRE 325
L E
Sbjct: 472 MAVLME 477
Score = 90.5 bits (223), Expect = 7e-18
Identities = 90/322 (27%), Positives = 139/322 (43%), Gaps = 9/322 (2%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
A DG+V ++ L + D L +H A GH V L++R +
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWL--LHE 126
GATP H AA + AE + + D D G + AA G ++ + L
Sbjct: 288 QGATPLH-YAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
+ + G LH AA+SG ++ +KLL + + V+ +PL+ AC+ GH +
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLL-LENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
Q L+K GA V L DG S LH AA G+ + L+ I +D G T L A
Sbjct: 406 IQTLIKG-GARVDLVDQDGHSLLHWAALGGNADVCQILIE-NKINPNVQDYAGRTPLQCA 463
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSL--RDED 303
A GG+ + L+ P ++D G T LH + NG ++ + L+ P+ +E+
Sbjct: 464 AYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEE 523
Query: 304 GYTAADLAEYHGHRDCAQYLRE 325
YT D A + Q++ E
Sbjct: 524 RYTPLDYALLGERHEVIQFMLE 545
Score = 87.4 bits (215), Expect = 6e-17
Identities = 93/339 (27%), Positives = 151/339 (44%), Gaps = 20/339 (5%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
AA +GD L+RL+ + D G + + A LDC L+ +A N+ H
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALL-KAGADVNKTDH 79
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
+ T H AA G+ + L+ +Q +D ++PLHL R P + LL
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQ-KDLEEMTPLHLTTRHRSPKCLALLLKFMA 138
Query: 129 SATLETREGARP--LHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQE---GH 183
++T++ + LH +A + +KLL H S++ G PL+ A
Sbjct: 139 PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK-HDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 184 LHLAQFLVKDCGADVHLRALD--GMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGAT 241
+H + ++ + L D G + LH A A G+ ++V L ++ +T+ DN T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 242 ALHFAARGGHTPILDRLL---LMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPS 298
LH+AA GH I+ LL GT I DS G TPLH AA++ E + + H PS
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGT-IPSDSQGATPLHYAAQSNFAETVKVFLKH---PS 313
Query: 299 LRDE---DGYTAADLAEYHGHRDCAQYLREVAQPVPLLM 334
++D+ +G T+ A G D + + + + + M
Sbjct: 314 VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 352
Score = 55.1 bits (131), Expect = 3e-07
Identities = 53/197 (26%), Positives = 79/197 (40%), Gaps = 5/197 (2%)
Query: 138 ARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGAD 197
A +H AAV+GD L+ L + + ++ + G +PL L A L+K GAD
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLK-AGAD 73
Query: 198 VHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDR 257
V+ +ALH AA +G+Y + L+T +D E T LH R L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLT-RRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 258 LLLMGTP---ILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYH 314
LL P +D T LH +A E + L+ H + + D +G A H
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 315 GHRDCAQYLREVAQPVP 331
+R + P
Sbjct: 193 KDPSAVHTVRCILDAAP 209
Score = 32.0 bits (71), Expect = 3.0
Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 1/86 (1%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
AA G + + L+E A P I D G +H + G+LD +K L+ A P +
Sbjct: 463 AAYGGYINCMAVLMENNA-DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521
Query: 69 NGATPAHDAAATGSLAELCWLVREGG 94
D A G E+ + E G
Sbjct: 522 EERYTPLDYALLGERHEVIQFMLEHG 547
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 102 bits (255), Expect = 1e-21
Identities = 93/306 (30%), Positives = 136/306 (44%), Gaps = 14/306 (4%)
Query: 30 GITDALGAGLVHHATRAGHLD-----CVKFLVQRAQLPG--NQRAHNGATPAHDAAATGS 82
GI D G +H A A H D V+ ++ A N + + G TP H A A G+
Sbjct: 176 GIPDVEGKIPLHWA--ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGN 233
Query: 83 LAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLET-REGARPL 141
+ + L C + D +PLH AA GH +V LL S T+ + +GA PL
Sbjct: 234 VTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPL 293
Query: 142 HHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH-LAQFLVKDCGADVHL 200
H+AA S +K+ H S + G + A +G L L D+++
Sbjct: 294 HYAAQSNFAETVKVF-LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 352
Query: 201 RALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLL 260
G +ALHAAA GH S V L+ + + A D T L A GH ++ L+
Sbjct: 353 ADKYGGTALHAAALSGHVSTVKLLLE-NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411
Query: 261 MGTPI-LRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDC 319
G + L D G + LH AA G + CQ L+ + ++P+++D G T A Y G+ +C
Sbjct: 412 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINC 471
Query: 320 AQYLRE 325
L E
Sbjct: 472 MAVLME 477
Score = 90.5 bits (223), Expect = 7e-18
Identities = 90/322 (27%), Positives = 139/322 (43%), Gaps = 9/322 (2%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
A DG+V ++ L + D L +H A GH V L++R +
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWL--LHE 126
GATP H AA + AE + + D D G + AA G ++ + L
Sbjct: 288 QGATPLH-YAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKS 346
Query: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHL 186
+ + G LH AA+SG ++ +KLL + + V+ +PL+ AC+ GH +
Sbjct: 347 DIDINMADKYGGTALHAAALSGHVSTVKLL-LENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFA 246
Q L+K GA V L DG S LH AA G+ + L+ I +D G T L A
Sbjct: 406 IQTLIKG-GARVDLVDQDGHSLLHWAALGGNADVCQILIE-NKINPNVQDYAGRTPLQCA 463
Query: 247 ARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSL--RDED 303
A GG+ + L+ P ++D G T LH + NG ++ + L+ P+ +E+
Sbjct: 464 AYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEE 523
Query: 304 GYTAADLAEYHGHRDCAQYLRE 325
YT D A + Q++ E
Sbjct: 524 RYTPLDYALLGERHEVIQFMLE 545
Score = 87.4 bits (215), Expect = 6e-17
Identities = 93/339 (27%), Positives = 151/339 (44%), Gaps = 20/339 (5%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
AA +GD L+RL+ + D G + + A LDC L+ +A N+ H
Sbjct: 21 AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALL-KAGADVNKTDH 79
Query: 69 NGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGH 128
+ T H AA G+ + L+ +Q +D ++PLHL R P + LL
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQ-KDLEEMTPLHLTTRHRSPKCLALLLKFMA 138
Query: 129 SATLETREGARP--LHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQE---GH 183
++T++ + LH +A + +KLL H S++ G PL+ A
Sbjct: 139 PGEVDTQDKNKQTALHWSAYYNNPEHVKLLIK-HDSNIGIPDVEGKIPLHWAANHKDPSA 197
Query: 184 LHLAQFLVKDCGADVHLRALD--GMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGAT 241
+H + ++ + L D G + LH A A G+ ++V L ++ +T+ DN T
Sbjct: 198 VHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRT 257
Query: 242 ALHFAARGGHTPILDRLL---LMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPS 298
LH+AA GH I+ LL GT I DS G TPLH AA++ E + + H PS
Sbjct: 258 PLHWAALLGHAQIVHLLLERNKSGT-IPSDSQGATPLHYAAQSNFAETVKVFLKH---PS 313
Query: 299 LRDE---DGYTAADLAEYHGHRDCAQYLREVAQPVPLLM 334
++D+ +G T+ A G D + + + + + M
Sbjct: 314 VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINM 352
Score = 55.1 bits (131), Expect = 3e-07
Identities = 53/197 (26%), Positives = 79/197 (40%), Gaps = 5/197 (2%)
Query: 138 ARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGAD 197
A +H AAV+GD L+ L + + ++ + G +PL L A L+K GAD
Sbjct: 15 ASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLK-AGAD 73
Query: 198 VHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDR 257
V+ +ALH AA +G+Y + L+T +D E T LH R L
Sbjct: 74 VNKTDHSQRTALHLAAQKGNYRFMKLLLT-RRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 258 LLLMGTP---ILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYH 314
LL P +D T LH +A E + L+ H + + D +G A H
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 315 GHRDCAQYLREVAQPVP 331
+R + P
Sbjct: 193 KDPSAVHTVRCILDAAP 209
Score = 32.0 bits (71), Expect = 3.0
Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 1/86 (1%)
Query: 9 AAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAH 68
AA G + + L+E A P I D G +H + G+LD +K L+ A P +
Sbjct: 463 AAYGGYINCMAVLMENNA-DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENN 521
Query: 69 NGATPAHDAAATGSLAELCWLVREGG 94
D A G E+ + E G
Sbjct: 522 EERYTPLDYALLGERHEVIQFMLEHG 547
>gi|24308163 fem-1 homolog a [Homo sapiens]
Length = 669
Score = 102 bits (254), Expect = 2e-21
Identities = 87/272 (31%), Positives = 128/272 (47%), Gaps = 25/272 (9%)
Query: 72 TPAHDAAATGSLAELCWLV----REGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE- 126
T ++AA G L L L+ RE L + A G +PL +AAR+GH +VE+L+
Sbjct: 5 TAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC 64
Query: 127 ------GHSATL--ETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLA 178
G S ET EGA PL A+ +G L ++ L G+SVNR TR+ ++PL A
Sbjct: 65 GASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLR-RGASVNRTTRTNSTPLRAA 123
Query: 179 CQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNE 238
C +GHL + ++LV + AD+ + G + L + +GH + +L+ + R +
Sbjct: 124 CFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLE-QGAQVNRRSAK 182
Query: 239 GATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSH----- 293
G TALH A G IL LL + RD +G TPL A+ G + L+
Sbjct: 183 GNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQE 242
Query: 294 -----HVDPSLRDEDGYTAADLAEYHGHRDCA 320
P L ED T+ A+ G C+
Sbjct: 243 QVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCS 274
Score = 83.6 bits (205), Expect = 9e-16
Identities = 75/258 (29%), Positives = 112/258 (43%), Gaps = 39/258 (15%)
Query: 9 AAKDGDVATLERLLEAGA---LGPGITDALGAGL-VHHATRAGHLDCVKFLVQRAQLPGN 64
AA+DG + L++LL + L + G G + A R GHLD V++LV R
Sbjct: 10 AARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRC----- 64
Query: 65 QRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLL 124
G+ E G + G PL A+ GH +V LL
Sbjct: 65 ----------------GASVEA-----GGSVHFDGETIEGAPPLWAASAAGHLDVVRSLL 103
Query: 125 HEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHL 184
G S TR + PL A G L ++ L H + + R G + L ++C +GH
Sbjct: 104 RRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHR 163
Query: 185 HLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTA---RDNEGAT 241
+A++L++ GA V+ R+ G +ALH A G ++ L +G A RD G T
Sbjct: 164 EIARYLLEQ-GAQVNRRSAKGNTALHDCAESGSLEILQLL-----LGCKARMERDGYGMT 217
Query: 242 ALHFAARGGHTPILDRLL 259
L A+ GHT I++ L+
Sbjct: 218 PLLAASVTGHTNIVEYLI 235
Score = 65.1 bits (157), Expect = 3e-10
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 32/191 (16%)
Query: 141 LHHAAVSGDLTCL-KLLTAAHGSSVNRRT---RSGASPLYLACQEGHLHLAQFLVKDCGA 196
+++AA G L L KLL+ ++ T G +PL +A + GHL + ++LV CGA
Sbjct: 7 VYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGA 66
Query: 197 DVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILD 256
V A H+ EGA L A+ GH ++
Sbjct: 67 SVE------------AGGSVHFD--------------GETIEGAPPLWAASAAGHLDVVR 100
Query: 257 RLLLMGTPILRDS-WGGTPLHDAAENGQMECCQTLVSHH-VDPSLRDEDGYTAADLAEYH 314
LL G + R + TPL A +G +E + LV H D + + G+T ++ Y
Sbjct: 101 SLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYK 160
Query: 315 GHRDCAQYLRE 325
GHR+ A+YL E
Sbjct: 161 GHREIARYLLE 171
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 101 bits (251), Expect = 4e-21
Identities = 87/307 (28%), Positives = 139/307 (45%), Gaps = 38/307 (12%)
Query: 6 ALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQ 65
A AA+ G++A L+ LL +G + D+ G L+ A AGH+DCV+ LV +
Sbjct: 16 AFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQ------- 68
Query: 66 RAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLH 125
G + Q SG + L AA+ GH +V +L
Sbjct: 69 ----------------------------GADINLQRESGTTALFFAAQQGHNDVVRFLFG 100
Query: 126 EGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLH 185
G S T++G L A+ G + ++ L HG++++ + GA+ L+LA Q G+L
Sbjct: 101 FGASTEFRTKDGGTALLAASQYGHMQVVETL-LKHGANIHDQLYDGATALFLAAQGGYLD 159
Query: 186 LAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHF 245
+ + L+ GA V+ DG + L A+ GH S VV ++ A N+G TAL
Sbjct: 160 VIRLLLAS-GAKVNQPRQDGTAPLWIASQMGH-SEVVRVMLLRGADRDAARNDGTTALLK 217
Query: 246 AARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGY 305
AA G+ ++ LL + G + LH A +G ++ L+ DPSLR++
Sbjct: 218 AANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANE 277
Query: 306 TAADLAE 312
A+L +
Sbjct: 278 LPAELTK 284
Score = 87.0 bits (214), Expect = 8e-17
Identities = 70/227 (30%), Positives = 108/227 (47%), Gaps = 9/227 (3%)
Query: 111 AARFGHPVLVEWLLHEGH-SATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTR 169
AAR G+ L++ LL+ G G L AA +G + C++ L G+ +N +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVL-QGADINLQRE 77
Query: 170 SGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTD 229
SG + L+ A Q+GH + +FL GA R DG +AL AA+ GH +V L+
Sbjct: 78 SGTTALFFAAQQGHNDVVRFLF-GFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH-- 134
Query: 230 IGLTARDN--EGATALHFAARGGHTPILDRLLLMGTPILRDSWGGT-PLHDAAENGQMEC 286
G D +GATAL AA+GG+ ++ LL G + + GT PL A++ G E
Sbjct: 135 -GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEV 193
Query: 287 CQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLL 333
+ ++ D DG TA A G+ D + L + + + +L
Sbjct: 194 VRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240
Score = 62.0 bits (149), Expect = 3e-09
Identities = 52/154 (33%), Positives = 72/154 (46%), Gaps = 4/154 (2%)
Query: 172 ASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTF-TDI 230
A+ + A + G+L L + L+ DV R G + L AA GH V LV DI
Sbjct: 13 ANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADI 72
Query: 231 GLTARDNEGATALHFAARGGHTPILDRLLLMGTPI-LRDSWGGTPLHDAAENGQMECCQT 289
L + G TAL FAA+ GH ++ L G R GGT L A++ G M+ +T
Sbjct: 73 NL--QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVET 130
Query: 290 LVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
L+ H + + DG TA LA G+ D + L
Sbjct: 131 LLKHGANIHDQLYDGATALFLAAQGGYLDVIRLL 164
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,723,747
Number of Sequences: 37866
Number of extensions: 2835660
Number of successful extensions: 29138
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 413
Number of HSP's successfully gapped in prelim test: 622
Number of HSP's that attempted gapping in prelim test: 17871
Number of HSP's gapped (non-prelim): 6668
length of query: 1005
length of database: 18,247,518
effective HSP length: 112
effective length of query: 893
effective length of database: 14,006,526
effective search space: 12507827718
effective search space used: 12507827718
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.