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Search of human proteins with 155722985
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|155722985 SMC5 protein [Homo sapiens]
(1101 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155722985 SMC5 protein [Homo sapiens] 2183 0.0
gi|214010216 SMC6 protein [Homo sapiens] 144 5e-34
gi|13375848 SMC6 protein [Homo sapiens] 144 5e-34
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 91 8e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 90 1e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 87 1e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 87 1e-16
gi|71061468 centromere protein E [Homo sapiens] 86 2e-16
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 84 6e-16
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 84 1e-15
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 84 1e-15
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 84 1e-15
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 80 1e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 80 1e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 79 3e-14
gi|118498356 kinectin 1 isoform a [Homo sapiens] 78 5e-14
gi|33620775 kinectin 1 isoform a [Homo sapiens] 78 5e-14
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 77 7e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 77 1e-13
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 75 3e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 75 3e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 75 3e-13
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 75 3e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 74 8e-13
gi|55770834 centromere protein F [Homo sapiens] 74 1e-12
gi|118498368 kinectin 1 isoform c [Homo sapiens] 73 2e-12
gi|58530840 desmoplakin isoform I [Homo sapiens] 72 2e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 72 2e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 72 4e-12
gi|118498362 kinectin 1 isoform b [Homo sapiens] 71 5e-12
>gi|155722985 SMC5 protein [Homo sapiens]
Length = 1101
Score = 2183 bits (5656), Expect = 0.0
Identities = 1101/1101 (100%), Positives = 1101/1101 (100%)
Query: 1 MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQSSGPFVEGSIVRISMEN 60
MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQSSGPFVEGSIVRISMEN
Sbjct: 1 MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQSSGPFVEGSIVRISMEN 60
Query: 61 FLTYDICEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSR 120
FLTYDICEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSR
Sbjct: 61 FLTYDICEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSR 120
Query: 121 GMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLP 180
GMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLP
Sbjct: 121 GMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLP 180
Query: 181 QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV 240
QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV
Sbjct: 181 QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV 240
Query: 241 QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK 300
QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK
Sbjct: 241 QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK 300
Query: 301 EGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALI 360
EGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALI
Sbjct: 301 EGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALI 360
Query: 361 VKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGE 420
VKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGE
Sbjct: 361 VKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGE 420
Query: 421 IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR 480
IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR
Sbjct: 421 IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR 480
Query: 481 VCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIA 540
VCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIA
Sbjct: 481 VCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIA 540
Query: 541 PKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERI 600
PKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERI
Sbjct: 541 PKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERI 600
Query: 601 ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLK 660
ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLK
Sbjct: 601 ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLK 660
Query: 661 EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKL 720
EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKL
Sbjct: 661 EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKL 720
Query: 721 MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISE 780
MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISE
Sbjct: 721 MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISE 780
Query: 781 KNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ 840
KNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ
Sbjct: 781 KNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ 840
Query: 841 TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEI 900
TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEI
Sbjct: 841 TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEI 900
Query: 901 EQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT 960
EQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT
Sbjct: 901 EQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT 960
Query: 961 ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE 1020
ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE
Sbjct: 961 ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE 1020
Query: 1021 INQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEP 1080
INQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEP
Sbjct: 1021 INQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEP 1080
Query: 1081 NTWNLKAFQRRRRRITFTQPS 1101
NTWNLKAFQRRRRRITFTQPS
Sbjct: 1081 NTWNLKAFQRRRRRITFTQPS 1101
>gi|214010216 SMC6 protein [Homo sapiens]
Length = 1091
Score = 144 bits (363), Expect = 5e-34
Identities = 247/1118 (22%), Positives = 466/1118 (41%), Gaps = 197/1118 (17%)
Query: 51 GSIVRISMENFLTYDIC-EVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADK 109
G I I ++NF+ + + G ++N +VG NG+GKS+++ A+ +GL G+ R
Sbjct: 46 GIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSS 105
Query: 110 VGFFVKRGCSRGMVEIEL-------FRAS---GNLVITREIDVAKNQSFWFINKKSTTQK 159
+ FVK G + + I L F+AS +++I + I + ++S+ KS T
Sbjct: 106 LKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSY---KLKSATGS 162
Query: 160 IV----EEKVAAL---NIQVGNLCQFLPQDKVGEFAKLSKIE------LLEATEKSIGPP 206
+V EE +A L NIQV N L Q+ +F + SK E ++AT+
Sbjct: 163 VVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQ-SKNEGDKYKFFMKATQLE-QMK 220
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML 266
E + Y E K R KE Q+ + TE ++ V++ ER+ Q + K +L E L
Sbjct: 221 EDYSYIMETKE-RTKE-QIHQGEERLTELKRQCVEKEERF-QSIAGLSTMKTNL---ESL 274
Query: 267 EAKRPWVEYENVRQEY----EEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEA 322
+ + W + ++ + +K+ DR RK++E Q+ R+ E E + +++
Sbjct: 275 KHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQV----RLNEAEQKYKDIQD 330
Query: 323 RIKEKATDIKEASQKCKQ-KQDVIERKD---------------------------KHIEE 354
++++ + + + +C K DV+ +K K IEE
Sbjct: 331 KLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEE 390
Query: 355 LQQALIVK-QNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDE 413
L+++ + E L+RQ++I ++ ++ QN+ EN N +I+ + + ++E
Sbjct: 391 LKKSTDQSLEPERLERQKKISWLKERVKAFQNQ----ENSVN--QEIEQFQQAIEKDKEE 444
Query: 414 KALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNN 473
+ E +D + +++ K + D K D+L+ RF A+L ++
Sbjct: 445 HGKIKREELDVKHALSYNQRQLKELKD----------SKTDRLK-RFGPNVPALLEAIDD 493
Query: 474 ---RDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDN 530
+ F + P+ I+++D + A IE+ + L+A+ + D V
Sbjct: 494 AYRQGHFTYKPVGPLGACIHLRDPELALAIESCL-KGLLQAYCCHNHADERVL------- 545
Query: 531 KKLRVNAVIAPKSSYADKAPSRSLNELKQY--------GFFSYLRELFDAPDPVMSYLCC 582
+ + P +S S NE+ F + L L V + L
Sbjct: 546 -QALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLID 604
Query: 583 QYHIHEVPVGTEKTRERIERVIQE--TRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVA 640
I V + + R Q+ ++ +TA+ V +YS S NT K
Sbjct: 605 MRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYS----SENTRPK-- 658
Query: 641 QFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLER 700
FL+ VD E LE +++ ++ + L AL + KH E ELL+R
Sbjct: 659 -FLSRDVDSE-ISDLENEVENKTAQILNLQQHLSALEKDIKHNE-----------ELLKR 705
Query: 701 -KTKKRQLEQKISSKLGSLKLMEQ-------DTCNLEEE--ERKASTKIKEINVQKAKLV 750
+ ++L+ KI + ++ +E D LE+E E K+ K+ E ++++ K
Sbjct: 706 CQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKEN 765
Query: 751 TELTNLIKICTSLHIQKVDLILQNTTVISE-KNKLESDYMAASSQL-----------RLT 798
E +KI K D I +SE + L+ + A S++
Sbjct: 766 MEHLKSLKIEAE---NKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQ 822
Query: 799 EQHFIELDENRQRLLQKCKEL---MKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLP 855
++H L++ ++ L K KEL M +ARQ+C P+ + + S
Sbjct: 823 KEHLDTLNKKKRELDMKEKELEEKMSQARQIC--------PERIEVE---------KSAS 865
Query: 856 MVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELD 915
++ +++ +I A R +E ++ +E + +L K L
Sbjct: 866 ILDKEINRLRQKIQAEHASHGDR------------EEIMRQYQEARETYLDLDSKVRTLK 913
Query: 916 QYRENISQVKERWLNPLKE----LVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGI 971
++ + + ++ E ++ L + F N S G+++ +NE +
Sbjct: 914 KFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNET------L 967
Query: 972 RIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINER 1031
I V+ + SGGERS ST+ ++++L + PFR +DE + MD +N R
Sbjct: 968 SISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRR 1027
Query: 1032 RVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVL 1069
++++ A + Q+ +TP+ + +LP S+ + +L
Sbjct: 1028 IAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRIL 1065
>gi|13375848 SMC6 protein [Homo sapiens]
Length = 1091
Score = 144 bits (363), Expect = 5e-34
Identities = 247/1118 (22%), Positives = 466/1118 (41%), Gaps = 197/1118 (17%)
Query: 51 GSIVRISMENFLTYDIC-EVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADK 109
G I I ++NF+ + + G ++N +VG NG+GKS+++ A+ +GL G+ R
Sbjct: 46 GIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSS 105
Query: 110 VGFFVKRGCSRGMVEIEL-------FRAS---GNLVITREIDVAKNQSFWFINKKSTTQK 159
+ FVK G + + I L F+AS +++I + I + ++S+ KS T
Sbjct: 106 LKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSY---KLKSATGS 162
Query: 160 IV----EEKVAAL---NIQVGNLCQFLPQDKVGEFAKLSKIE------LLEATEKSIGPP 206
+V EE +A L NIQV N L Q+ +F + SK E ++AT+
Sbjct: 163 VVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQ-SKNEGDKYKFFMKATQLE-QMK 220
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML 266
E + Y E K R KE Q+ + TE ++ V++ ER+ Q + K +L E L
Sbjct: 221 EDYSYIMETKE-RTKE-QIHQGEERLTELKRQCVEKEERF-QSIAGLSTMKTNL---ESL 274
Query: 267 EAKRPWVEYENVRQEY----EEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEA 322
+ + W + ++ + +K+ DR RK++E Q+ R+ E E + +++
Sbjct: 275 KHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQV----RLNEAEQKYKDIQD 330
Query: 323 RIKEKATDIKEASQKCKQ-KQDVIERKD---------------------------KHIEE 354
++++ + + + +C K DV+ +K K IEE
Sbjct: 331 KLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEE 390
Query: 355 LQQALIVK-QNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDE 413
L+++ + E L+RQ++I ++ ++ QN+ EN N +I+ + + ++E
Sbjct: 391 LKKSTDQSLEPERLERQKKISWLKERVKAFQNQ----ENSVN--QEIEQFQQAIEKDKEE 444
Query: 414 KALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNN 473
+ E +D + +++ K + D K D+L+ RF A+L ++
Sbjct: 445 HGKIKREELDVKHALSYNQRQLKELKD----------SKTDRLK-RFGPNVPALLEAIDD 493
Query: 474 ---RDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDN 530
+ F + P+ I+++D + A IE+ + L+A+ + D V
Sbjct: 494 AYRQGHFTYKPVGPLGACIHLRDPELALAIESCL-KGLLQAYCCHNHADERVL------- 545
Query: 531 KKLRVNAVIAPKSSYADKAPSRSLNELKQY--------GFFSYLRELFDAPDPVMSYLCC 582
+ + P +S S NE+ F + L L V + L
Sbjct: 546 -QALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLID 604
Query: 583 QYHIHEVPVGTEKTRERIERVIQE--TRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVA 640
I V + + R Q+ ++ +TA+ V +YS S NT K
Sbjct: 605 MRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYS----SENTRPK-- 658
Query: 641 QFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLER 700
FL+ VD E LE +++ ++ + L AL + KH E ELL+R
Sbjct: 659 -FLSRDVDSE-ISDLENEVENKTAQILNLQQHLSALEKDIKHNE-----------ELLKR 705
Query: 701 -KTKKRQLEQKISSKLGSLKLMEQ-------DTCNLEEE--ERKASTKIKEINVQKAKLV 750
+ ++L+ KI + ++ +E D LE+E E K+ K+ E ++++ K
Sbjct: 706 CQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKEN 765
Query: 751 TELTNLIKICTSLHIQKVDLILQNTTVISE-KNKLESDYMAASSQL-----------RLT 798
E +KI K D I +SE + L+ + A S++
Sbjct: 766 MEHLKSLKIEAE---NKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQ 822
Query: 799 EQHFIELDENRQRLLQKCKEL---MKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLP 855
++H L++ ++ L K KEL M +ARQ+C P+ + + S
Sbjct: 823 KEHLDTLNKKKRELDMKEKELEEKMSQARQIC--------PERIEVE---------KSAS 865
Query: 856 MVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELD 915
++ +++ +I A R +E ++ +E + +L K L
Sbjct: 866 ILDKEINRLRQKIQAEHASHGDR------------EEIMRQYQEARETYLDLDSKVRTLK 913
Query: 916 QYRENISQVKERWLNPLKE----LVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGI 971
++ + + ++ E ++ L + F N S G+++ +NE +
Sbjct: 914 KFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNET------L 967
Query: 972 RIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINER 1031
I V+ + SGGERS ST+ ++++L + PFR +DE + MD +N R
Sbjct: 968 SISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRR 1027
Query: 1032 RVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVL 1069
++++ A + Q+ +TP+ + +LP S+ + +L
Sbjct: 1028 IAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRIL 1065
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 90.5 bits (223), Expect = 8e-18
Identities = 191/972 (19%), Positives = 399/972 (41%), Gaps = 190/972 (19%)
Query: 159 KIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSK-IELL-EATEKSIGPPEMHKYH---- 212
+IV+EK + N CQ L +D + E A+L K IE L E +E+ I E H
Sbjct: 513 EIVQEKQSLQN------CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 213 -------------CELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRH 259
+K++ ++ K L S KE + L K+ + K+++E + E+
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 260 LDLIEMLEAKRPWVEYEN--VRQEYEEVKLVRDRVK----------EEVRKLK---EGQI 304
E LE + +E EN ++++ +K+ ++++ E RKLK +
Sbjct: 627 A---EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 305 PVTCRIEEMENERHNLEAR---IKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIV 361
+T ++E +E E L+ ++ +K AS K Q Q + + E+L++ L +
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 362 -----KQNEELD------------RQRRIGNTRKMIEDLQNELKTTE-NCENLQPQIDAI 403
K+ E L+ Q+ + N+ K I+ L++EL+ E + LQ ++ +
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 404 ---TNDLRRIQDEKALCEGEIIDKRRERETLEKEKK-----------SVDDHIVRFDNLM 449
+ L +++ E E E ++++ LEKE K +++++ V+ NL
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL- 862
Query: 450 NQKEDKLRQR----FRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIP 505
+KE+K + ++++ + L + +R I + ++++ ++ ++
Sbjct: 863 -EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQM 921
Query: 506 SNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSY 565
+NDL E L+++ NK+ + + +++ S +L + S
Sbjct: 922 NNDLEKLTHE--------LEKIGLNKE---------RLLHDEQSTDDSRYKLLESKLEST 964
Query: 566 LRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF 625
L++ + + ++ L + + E ++ R+ ++ V + + EE+ V
Sbjct: 965 LKKSLEIKEEKIAAL--EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV----- 1017
Query: 626 YSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEH 685
S+ IS + E + +E R+L V LI +
Sbjct: 1018 QSSPPISGEDN-----------------KWERESQETTRELLKVKDRLIEVE-------- 1052
Query: 686 KDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQ 745
++N Q +K+ L KT+ +QLE + ++ + +++ T +L+E+ T+ ++ V+
Sbjct: 1053 RNNATLQAEKQAL--KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110
Query: 746 KAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDY---------------MA 790
+ L ++ T+L+ L IQ+ L +N +VI E+ L+S Y
Sbjct: 1111 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1170
Query: 791 ASSQLRLTEQH------FIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVP 844
AS L +H L+ + L + +L+K+ Q+ +L E+ L E + +
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL--EKMLKVEQEKMLL 1228
Query: 845 TIPN------------GHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTG--LNPTIV 890
N G N L + L L E + L T+ ++ S L T +
Sbjct: 1229 ENKNHETVAAEYKKLCGENDRLNHTYSQL---LKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 891 Q-EYTKREEEIEQL---TEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNF 946
+ E++K +E+ +QL + +L + L Q + N+ + L+ ++ L+ +
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345
Query: 947 FSSMQCAGEVDLHTENEEDYDKYG------IRIRVKFRSSTQLHELTPHHQSGGERSVST 1000
S H E + DK ++ K + ++ +P + G ++
Sbjct: 1346 MESKDL-----FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM 1400
Query: 1001 MLYLMALQELNR 1012
+ + +++NR
Sbjct: 1401 RKLIKSKKDINR 1412
Score = 75.1 bits (183), Expect = 3e-13
Identities = 160/840 (19%), Positives = 346/840 (41%), Gaps = 107/840 (12%)
Query: 188 AKLSKI--ELLEATEKSIG-PPEMHKYHCELKNLREKEKQLETSCKEKTEY------LQK 238
AK+ ++ EL E TE+ + E+ + ELK L+++ L + + Y L++
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE 317
Query: 239 MVQRNERYKQDVERFYERKRHLDLI-----EMLEAKRPWVEYENVRQEYEEVKLVRDRVK 293
R ++ + +V R+ ER ++ E+ E + +E + + ++ E R
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS--- 374
Query: 294 EEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDV--------- 344
+++ +L++ + + ++ +ME ER +I+E + KQ D
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
Query: 345 -IERKDKHIEELQQALIVKQNE---------ELDRQ---RRIGNTRKMIEDLQNE----L 387
I R + E Q++L + NE E++ Q + + R ++ ++ L
Sbjct: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
Query: 388 KTTENCENLQPQIDAITNDLRRIQDEKAL--CEGEIIDKRRERETLEKEKKSVDDHIVRF 445
K + + L +++ + N++ +Q++++L C+ D +E+ LEK +++ ++ R
Sbjct: 495 KMEKENQRLSKKVEILENEI--VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 446 DNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAK------- 498
++ Q+ + L Q R K ++ + + +I +K +K
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 499 -------YIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAV--IAPKSSYADKA 549
Y E + +L + +++ E+ K++ N K+ + + ++S ++
Sbjct: 613 IKKELEHYKEKGERAEELENELHHLEKENELLQKKI-TNLKITCEKIEALEQENSELERE 671
Query: 550 PSRSLNELKQYGFFSYLRELFDAPDPVM--SYLCCQYHIHEVPVGTEKTRE-RIERVIQE 606
+ L + ++ E + + + L + ++ + + K + ++E E
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 607 TRLKQIYTAEEKYVVKTSFYSNKVIS-SNTSLKVA-QFLTVTVDLEQRR--HLEEQLKEI 662
+ +Q+ E ++K SF + + S L + Q L T++ ++ LE +L+++
Sbjct: 732 SEKEQLKKGLE--LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 663 HRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLE-------QKISSKL 715
+ Q + L L+ +SK LE + E + ++E + + K+QLE Q+ K
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 716 GSLKLMEQDTCNLEEEERKASTKI---KEINVQKAKLVTELTNLIKICTSLHIQKVDLIL 772
+L+ NLE+E + S +I KE V+ +L E L+K T I L+
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT---IDIKTLVT 906
Query: 773 QNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAE 832
++SEK K + ++ L ++ N++RLL + ++ E
Sbjct: 907 LREDLVSEKLKTQQ----MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE 962
Query: 833 QTLPQEYQTQVPTI---------PNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFT 883
TL + + + I +N L + + + + EER S
Sbjct: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--- 1019
Query: 884 GLNPTIVQEYTKREEEIEQLTEEL---KGKKVELDQYRENISQVKERWLNPLKELVEKIN 940
+P I E K E E ++ T EL K + +E+++ + K+ LK+L + N
Sbjct: 1020 --SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077
Score = 62.8 bits (151), Expect = 2e-09
Identities = 118/672 (17%), Positives = 268/672 (39%), Gaps = 99/672 (14%)
Query: 310 IEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDR 369
+E + + ++E +K A +K +I+ +D+H E I++ +EE D
Sbjct: 176 MEVTDMSQEDIEPLLKNMALHLKR----------LIDERDEHSET-----IIELSEERDG 220
Query: 370 QRRIGNTRKMIEDLQNE--LKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRE 427
+ + + +K TE+ ++L ++ +RR++ E +++D ++E
Sbjct: 221 LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE 280
Query: 428 RETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDA-------VLWLRNNRDKFKQR 480
E +E E K + +N+ + + + +RD DA V L + ++K+R
Sbjct: 281 LEQMEIELKRLQQ-----ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 481 VCEPIMLTINMKDNKNAKYI--------ENHIPSNDLRAFVFESQEDMEVFLKE------ 526
+ + +++ K + E+ + R+ E + LK
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 527 -VRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGF----FSYLRELFDAPDPVMSY-- 579
RD + ++ ++ ++ + A +S++E G+ S EL +AP + +
Sbjct: 396 MERDMDRKKIEELM-EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
Query: 580 --------LCCQYHIHEVPVGTEKTRERIERVI-QETRLKQIYTAEEKYVVKTSFYSNKV 630
L + + E+ R ++ V +++ ++ ++ K N++
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 631 ISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNEL 690
+ SL+ Q L+ + ++++ LE+ ++ + + + + L + ++HL + L
Sbjct: 515 VQEKQSLQNCQNLSKDL-MKEKAQLEKTIETLR---ENSERQIKILEQENEHLNQTVSSL 570
Query: 691 RQKKKELLERKTKKRQLEQKI--------SSKLGSLKLMEQDTCNLEEEERKASTKIKEI 742
RQ+ + E + K + E KI SSKL ++ ++ E ++ + +E+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 743 NVQKAKLVTELTNLIKICTSLHI--QKVDLILQNTTVISEKN----KLESDYMAASSQLR 796
+ L E L K T+L I +K++ + Q + + +N K + + QL
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 797 LTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPM 856
E+ +LDE L + + L + ++ L E N L
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE------------------NKELES 732
Query: 857 VFQDLPNTLDEIDALLTEERSRASCFTGL---NPTIVQEYTKREEEIEQLTEELKGKKVE 913
+ L L+ + A + + GL N + + ++I+QL EL+ ++E
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 914 LDQYRENISQVK 925
++N+ ++K
Sbjct: 793 NQTLQKNLEELK 804
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 89.7 bits (221), Expect = 1e-17
Identities = 191/972 (19%), Positives = 398/972 (40%), Gaps = 191/972 (19%)
Query: 159 KIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSK-IELL-EATEKSIGPPEMHKYH---- 212
+IV+EK + N CQ L +D + E A+L K IE L E +E+ I E H
Sbjct: 513 EIVQEKQSLQN------CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 213 -------------CELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRH 259
+K++ ++ K L S KE + L K+ + K+++E + E+
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 260 LDLIEMLEAKRPWVEYEN--VRQEYEEVKLVRDRVK----------EEVRKLK---EGQI 304
E LE + +E EN ++++ +K+ ++++ E RKLK +
Sbjct: 627 A---EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 305 PVTCRIEEMENERHNLEAR---IKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIV 361
+T ++E +E E L+ ++ +K AS K Q Q + + E+L++ L +
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 362 -----KQNEELD------------RQRRIGNTRKMIEDLQNELKTTE-NCENLQPQIDAI 403
K+ E L+ Q+ + N+ K I+ L++EL+ E + LQ ++ +
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 404 ---TNDLRRIQDEKALCEGEIIDKRRERETLEKEKK-----------SVDDHIVRFDNLM 449
+ L +++ E E E ++++ LEKE K +++++ V+ NL
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL- 862
Query: 450 NQKEDKLRQR----FRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIP 505
+KE+K + ++++ + L + +R I + ++++ ++ ++
Sbjct: 863 -EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQM 921
Query: 506 SNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSY 565
+NDL E L+++ NK+ ++ D+ + +L + S
Sbjct: 922 NNDLEKLTHE--------LEKIGLNKERLLH----------DEQSTDDRYKLLESKLEST 963
Query: 566 LRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF 625
L++ + + ++ L + + E ++ R+ ++ V + + EE+ V
Sbjct: 964 LKKSLEIKEEKIAAL--EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV----- 1016
Query: 626 YSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEH 685
S+ IS + E + +E R+L V LI +
Sbjct: 1017 QSSPPISGEDN-----------------KWERESQETTRELLKVKDRLIEVE-------- 1051
Query: 686 KDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQ 745
++N Q +K+ L KT+ +QLE + ++ + +++ T +L+E+ T+ ++ V+
Sbjct: 1052 RNNATLQAEKQAL--KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1109
Query: 746 KAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDY---------------MA 790
+ L ++ T+L+ L IQ+ L +N +VI E+ L+S Y
Sbjct: 1110 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1169
Query: 791 ASSQLRLTEQH------FIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVP 844
AS L +H L+ + L + +L+K+ Q+ +L E+ L E + +
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL--EKMLKVEQEKMLL 1227
Query: 845 TIPN------------GHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTG--LNPTIV 890
N G N L + L L E + L T+ ++ S L T +
Sbjct: 1228 ENKNHETVAAEYKKLCGENDRLNHTYSQL---LKETEVLQTDHKNLKSLLNNSKLEQTRL 1284
Query: 891 Q-EYTKREEEIEQL---TEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNF 946
+ E++K +E+ +QL + +L + L Q + N+ + L+ ++ L+ +
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1344
Query: 947 FSSMQCAGEVDLHTENEEDYDKYG------IRIRVKFRSSTQLHELTPHHQSGGERSVST 1000
S H E + DK ++ K + ++ +P + G ++
Sbjct: 1345 MESKDL-----FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM 1399
Query: 1001 MLYLMALQELNR 1012
+ + +++NR
Sbjct: 1400 RKLIKSKKDINR 1411
Score = 73.6 bits (179), Expect = 1e-12
Identities = 161/840 (19%), Positives = 347/840 (41%), Gaps = 108/840 (12%)
Query: 188 AKLSKI--ELLEATEKSIG-PPEMHKYHCELKNLREKEKQLETSCKEKTEY------LQK 238
AK+ ++ EL E TE+ + E+ + ELK L+++ L + + Y L++
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE 317
Query: 239 MVQRNERYKQDVERFYERKRHLDLI-----EMLEAKRPWVEYENVRQEYEEVKLVRDRVK 293
R ++ + +V R+ ER ++ E+ E + +E + + ++ E R
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS--- 374
Query: 294 EEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDV--------- 344
+++ +L++ + + ++ +ME ER +I+E + KQ D
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
Query: 345 -IERKDKHIEELQQALIVKQNE---------ELDRQ---RRIGNTRKMIEDLQNE----L 387
I R + E Q++L + NE E++ Q + + R ++ ++ L
Sbjct: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
Query: 388 KTTENCENLQPQIDAITNDLRRIQDEKAL--CEGEIIDKRRERETLEKEKKSVDDHIVRF 445
K + + L +++ + N++ +Q++++L C+ D +E+ LEK +++ ++ R
Sbjct: 495 KMEKENQRLSKKVEILENEI--VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 446 DNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAK------- 498
++ Q+ + L Q R K ++ + + +I +K +K
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 499 -------YIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAV--IAPKSSYADKA 549
Y E + +L + +++ E+ K++ N K+ + + ++S ++
Sbjct: 613 IKKELEHYKEKGERAEELENELHHLEKENELLQKKI-TNLKITCEKIEALEQENSELERE 671
Query: 550 PSRSLNELKQYGFFSYLRELFDAPDPVM--SYLCCQYHIHEVPVGTEKTRE-RIERVIQE 606
+ L + ++ E + + + L + ++ + + K + ++E E
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
Query: 607 TRLKQIYTAEEKYVVKTSFYSNKVIS-SNTSLKVA-QFLTVTVDLEQRR--HLEEQLKEI 662
+ +Q+ E ++K SF + + S L + Q L T++ ++ LE +L+++
Sbjct: 732 SEKEQLKKGLE--LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 663 HRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLE-------QKISSKL 715
+ Q + L L+ +SK LE + E + ++E + + K+QLE Q+ K
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 716 GSLKLMEQDTCNLEEEERKASTKI---KEINVQKAKLVTELTNLIKICTSLHIQKVDLIL 772
+L+ NLE+E + S +I KE V+ +L E L+K T I L+
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT---IDIKTLVT 906
Query: 773 QNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAE 832
++SEK K + ++ L ++ N++RLL + R + + E
Sbjct: 907 LREDLVSEKLKTQQ----MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK-LLESKLE 961
Query: 833 QTLPQEYQTQVPTI---------PNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFT 883
TL + + + I +N L + + + + EER S
Sbjct: 962 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--- 1018
Query: 884 GLNPTIVQEYTKREEEIEQLTEEL---KGKKVELDQYRENISQVKERWLNPLKELVEKIN 940
+P I E K E E ++ T EL K + +E+++ + K+ LK+L + N
Sbjct: 1019 --SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076
Score = 62.8 bits (151), Expect = 2e-09
Identities = 118/672 (17%), Positives = 268/672 (39%), Gaps = 99/672 (14%)
Query: 310 IEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDR 369
+E + + ++E +K A +K +I+ +D+H E I++ +EE D
Sbjct: 176 MEVTDMSQEDIEPLLKNMALHLKR----------LIDERDEHSET-----IIELSEERDG 220
Query: 370 QRRIGNTRKMIEDLQNE--LKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRE 427
+ + + +K TE+ ++L ++ +RR++ E +++D ++E
Sbjct: 221 LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE 280
Query: 428 RETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDA-------VLWLRNNRDKFKQR 480
E +E E K + +N+ + + + +RD DA V L + ++K+R
Sbjct: 281 LEQMEIELKRLQQ-----ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335
Query: 481 VCEPIMLTINMKDNKNAKYI--------ENHIPSNDLRAFVFESQEDMEVFLKE------ 526
+ + +++ K + E+ + R+ E + LK
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 527 -VRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGF----FSYLRELFDAPDPVMSY-- 579
RD + ++ ++ ++ + A +S++E G+ S EL +AP + +
Sbjct: 396 MERDMDRKKIEELM-EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
Query: 580 --------LCCQYHIHEVPVGTEKTRERIERVI-QETRLKQIYTAEEKYVVKTSFYSNKV 630
L + + E+ R ++ V +++ ++ ++ K N++
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 631 ISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNEL 690
+ SL+ Q L+ + ++++ LE+ ++ + + + + L + ++HL + L
Sbjct: 515 VQEKQSLQNCQNLSKDL-MKEKAQLEKTIETLR---ENSERQIKILEQENEHLNQTVSSL 570
Query: 691 RQKKKELLERKTKKRQLEQKI--------SSKLGSLKLMEQDTCNLEEEERKASTKIKEI 742
RQ+ + E + K + E KI SSKL ++ ++ E ++ + +E+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 743 NVQKAKLVTELTNLIKICTSLHI--QKVDLILQNTTVISEKN----KLESDYMAASSQLR 796
+ L E L K T+L I +K++ + Q + + +N K + + QL
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 797 LTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPM 856
E+ +LDE L + + L + ++ L E N L
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE------------------NKELES 732
Query: 857 VFQDLPNTLDEIDALLTEERSRASCFTGL---NPTIVQEYTKREEEIEQLTEELKGKKVE 913
+ L L+ + A + + GL N + + ++I+QL EL+ ++E
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 914 LDQYRENISQVK 925
++N+ ++K
Sbjct: 793 NQTLQKNLEELK 804
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 86.7 bits (213), Expect = 1e-16
Identities = 158/844 (18%), Positives = 326/844 (38%), Gaps = 116/844 (13%)
Query: 293 KEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIER---KD 349
+EE+ K++E Q+ R+ EME + L A + ++ ++ C + +++ R K
Sbjct: 851 EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910
Query: 350 KHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRR 409
+ +EE+ L + EE +R + + +K K +N + L+ Q++ + ++
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKK---------KMQQNIQELEEQLEEEESARQK 961
Query: 410 IQDEKALCEGEIIDKRRERETLE-------KEKKSVDDHIVRFDNLMNQKEDKLRQ--RF 460
+Q EK E ++ E+ LE KEKK ++D I F + ++E+K + +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 461 RDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNA----KYIENHIPSNDLRAFVFES 516
++ ++A++ R + +++ + + T + + + E +L+ + +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 517 QEDMEVFLKEVRDN--------KKLR--VNAVIAPKSSYADKAPSRSLNELKQYGFFSYL 566
+E+++ L V + KK+R + + + + SR+ E ++ L
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 567 RELFDAPDPVMSYLCCQYHI-----HEVPV---GTEKTRERIERVIQETRLKQIYTAEE- 617
L + + Q + EV + E+ + E IQE R K EE
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 618 ------KYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDS 671
VK + K N ++A V V L+ + E + K++ +LQ +
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELAN--EVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 672 GLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEE 731
L K +L+ + + ++ K++ +L+ QDT L +E
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 732 ERK----ASTKIKEINVQKAKLVTELT-------NLIKICTSLHIQKVDLILQN------ 774
E + STK+K++ +K +L NL K +LH Q D+ +
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 775 -TTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELM----KRARQVCNL 829
T K KL+ D S + + +L++ + RL Q+ +L+ + + CNL
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Query: 830 GAEQTLPQEYQTQVPTIPNGHNS-----------------SLPMVFQDLPNTLDEIDALL 872
+Q + + TI + SL ++ E++ L
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 873 TEERSRASCFTGLNPTI---VQEYTKREEEIEQLTEELKGKKVELD-----------QYR 918
+ R+ + V E K + +EQ EE+K + EL+ +
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 919 ENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFR 978
N+ +K ++ L+ E+ EK ++ ++ E E++ + + + + +
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR-----EMEAELEDERKQRSMAVAARKK 1614
Query: 979 SSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPI------NERR 1032
L +L H S + + L LQ + R +D+ + I NE++
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674
Query: 1033 VFEM 1036
+ M
Sbjct: 1675 LKSM 1678
Score = 53.1 bits (126), Expect = 1e-06
Identities = 143/744 (19%), Positives = 298/744 (40%), Gaps = 146/744 (19%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K EL N+ Q ++ K+ L K E QD + + + L + K
Sbjct: 1277 KLQVELDNVTGLLSQSDS----KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332
Query: 270 RPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKAT 329
+ E + R++ EE + + +++++ L + ++E+ E ++
Sbjct: 1333 QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK 1392
Query: 330 DIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKT 389
D++ SQ+ ++K ++ +K LQQ ELD ++ DL ++ ++
Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQ--------ELD---------DLLVDLDHQRQS 1435
Query: 390 TENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVR-FDNL 448
N E Q + D + + + I + A E D R E E EKE K++ + R +
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYA----EERD-RAEAEAREKETKALS--LARALEEA 1488
Query: 449 MNQKE--DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPS 506
M QK ++L ++FR + L +++D + V E K+ + +E +
Sbjct: 1489 MEQKAELERLNKQFRTEMED---LMSSKDDVGKSVHEL---------EKSKRALEQQVEE 1536
Query: 507 NDLRAFVFESQEDMEVFLKEVRDNK-KLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSY 565
+ E++E L+ D K +L VN D +E K+
Sbjct: 1537 MKTQL------EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590
Query: 566 LRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF 625
+RE+ E + E+ ++R V +L+ E ++ +
Sbjct: 1591 VREM------------------EAELEDER-KQRSMAVAARKKLEMDLKDLEAHIDSANK 1631
Query: 626 YSNKVISSNTSLKVAQFLTVTVDLEQRRHLEE----QLKEIHRKLQAVDSGLIALRETSK 681
++ I L+ AQ +L+ R E Q KE +KL+++++ +I L+E
Sbjct: 1632 NRDEAIKQLRKLQ-AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1690
Query: 682 HLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
E + +Q++ EL + E SS G+L L EE+R+ +I +
Sbjct: 1691 AAERAKRQAQQERDELAD--------EIANSSGKGALAL---------EEKRRLEARIAQ 1733
Query: 742 INVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNK---LESDYMAASSQLRLT 798
+ ++++ NT +I+++ K L+ D + ++ L L
Sbjct: 1734 LE----------------------EELEEEQGNTELINDRLKKANLQIDQI--NTDLNLE 1769
Query: 799 EQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVF 858
H + + RQ+L ++ KEL + +++ E T+ +Y+ + + + + +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEM-----EGTVKSKYKASITAL----EAKIAQLE 1820
Query: 859 QDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYR 918
+ L N T+ER +A+C ++ + E++++ + ++ ++ +QY+
Sbjct: 1821 EQLDNE--------TKER-QAAC---------KQVRRTEKKLKDVLLQVDDERRNAEQYK 1862
Query: 919 ENISQVKERWLNPLKELVEKINEK 942
+ + R L LK +E+ E+
Sbjct: 1863 DQADKASTR-LKQLKRQLEEAEEE 1885
Score = 41.6 bits (96), Expect = 0.004
Identities = 56/308 (18%), Positives = 116/308 (37%), Gaps = 23/308 (7%)
Query: 196 LEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYE 255
LE E + E K E+ NL+ + Q E + + E ++ ++ R +++E E
Sbjct: 1541 LEELEDELQATEDAKLRLEV-NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599
Query: 256 RKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMEN 315
+R + + K+ ++ +++ + RD +++RKL+ +++
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 316 ERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNE---------- 365
R + A+ KE +K + Q Q+ + ++ + QQ +E
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 366 ELDRQRRI-GNTRKMIEDLQNELKTTE----NCENLQPQIDAITNDLRRIQDEKALCEGE 420
L+ +RR+ ++ E+L+ E TE + QID I DL L
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN-------LERSH 1772
Query: 421 IIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR 480
R+ LE++ K + + + + K + +N K +Q
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 481 VCEPIMLT 488
C+ + T
Sbjct: 1833 ACKQVRRT 1840
Score = 40.8 bits (94), Expect = 0.007
Identities = 53/255 (20%), Positives = 106/255 (41%), Gaps = 32/255 (12%)
Query: 683 LEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEI 742
+ ++ E+ K++EL++ + K+ E +++ + + L+E+ + + E
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 743 NVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHF 802
+A+L + L +IC L + + + + +EK K++ + QL
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE------ 953
Query: 803 IELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLP 862
E + RQ+L Q+ + E L + + Q+ I N L + L
Sbjct: 954 -EEESARQKL------------QLEKVTTEAKLKKLEEEQI--ILEDQNCKLAKEKKLLE 998
Query: 863 NTLDEIDALLTEERSRASCFTGLNP------TIVQEYTKREE----EIEQLTEELKGKKV 912
+ + E LTEE ++ L T ++E +REE E+E+ +L+G
Sbjct: 999 DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDST 1058
Query: 913 EL-DQYRENISQVKE 926
+L DQ E +Q+ E
Sbjct: 1059 DLSDQIAELQAQIAE 1073
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 86.7 bits (213), Expect = 1e-16
Identities = 177/813 (21%), Positives = 328/813 (40%), Gaps = 134/813 (16%)
Query: 254 YERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEM 313
Y + RH + +P ++ V ++ EE++ +D EE+ K+KE Q V +EEM
Sbjct: 826 YLKLRHWQWWRVFTKVKPLLQ---VTRQEEELQ-AKD---EELLKVKEKQTKVEGELEEM 878
Query: 314 ENERHNLEARIKEKATDIKEASQKCKQKQDVIER---KDKHIEELQQALIVKQNEELDRQ 370
E + L A ++ ++ + +++ R K + +EE+ L + EE +R
Sbjct: 879 ERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERN 938
Query: 371 RRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERET 430
+ + N +K K + ++L+ Q+D +++Q EK E +I E
Sbjct: 939 QILQNEKK---------KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL 989
Query: 431 LE-------KEKKSVDDHIVRFDNLMNQKEDKLRQ--RFRDTYDAVLWLRNNRDKFKQRV 481
LE KEKK ++D I + + ++E+K + + R+ + ++ R K +++
Sbjct: 990 LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKT 1049
Query: 482 CEPIMLTINMKDNKNA----KYIENHIPSNDLRAFVFESQEDMEVFL-----KEVRDNKK 532
+ + D + + E ++L+ + + +E+++ L + + N
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109
Query: 533 LRV----NAVIAP-KSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIH 587
L+V A IA + + + SR+ E ++ L L + + Q +
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169
Query: 588 --------EVPVGTEKTRERIERVIQETRLKQIYTAEE-------KYVVKTSFYSNK--V 630
E+ E+ + E IQ+ R + EE K + NK +
Sbjct: 1170 TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 1229
Query: 631 ISSNTSL----KVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHK 686
+ N L KV Q + + +R+ L+ Q++E+H K+ D + L E + L+
Sbjct: 1230 ETDNKELACEVKVLQQVKAESE-HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ-- 1286
Query: 687 DNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERK----ASTKIKEI 742
NEL LLE KK K + SL+ QDT L +EE + S++I+++
Sbjct: 1287 -NEL-DNVSTLLEEAEKK---GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 743 NVQKAKLVTE-------LTNLIKICTSLHIQ------KVDLILQNTTVISE-KNKLESDY 788
+K L + NL K +L Q KVD L + E K KL D
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 789 MAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPN 848
A S +L + +L++ + RL Q+ +L T+ ++Q QV +
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDL--------------TVDLDHQRQVAS--- 1444
Query: 849 GHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPT-------IVQEYTKREEEIE 901
+ F L I A EER RA T ++E + +EE E
Sbjct: 1445 -NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503
Query: 902 QLTEELK-------------GKKV-ELDQYRENISQVKERWLNPLKELVEKINE------ 941
+ ++L+ GK V EL++ + + Q E L+EL +++
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 942 KFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIR 974
+ +M+ E DL T +E++ +K + I+
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596
Score = 67.8 bits (164), Expect = 5e-11
Identities = 155/861 (18%), Positives = 355/861 (41%), Gaps = 113/861 (13%)
Query: 152 NKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIE----LLE------ATEK 201
N+K Q +++ L+ + G Q L +KV AK+ K+E LLE EK
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGAR-QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 202 SIGPPEMHKYHCELKNLREKEKQLETSCKEKTEY----LQKMVQRNERYKQDVERFYERK 257
+ + + +L EK K L + K E L++ +++ E+ +Q++E+ K
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEK---AK 1057
Query: 258 RHLD--------LIEMLEAKRPWVEYENVRQEYE-----------------EVKLVRDRV 292
R LD I L+A+ ++ + ++E E +K+VR+ +
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE-L 1116
Query: 293 KEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHI 352
+ ++ +L+E + E ++ +L ++ T++++ +Q++ ++++ +
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 353 EELQQALIVKQNEELDRQRRIGNTRKM----IEDLQNELKTTENCE-NLQPQIDAITNDL 407
EL++AL + E + + +I + R+ +E+L +L+ + + NL+ + D
Sbjct: 1177 AELKKAL---EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Query: 408 RRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAV 467
+ + E + + + +R+ L+ + + + + D L + +K + + +
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Query: 468 LWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEV 527
L K + + L ++D + E N L + + + +E+ ++
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQQ 1352
Query: 528 RDNKKLRVNA---VIAPKSSYADKAPS--------RSLNELKQY------GFFSYLRE-- 568
+ ++ R N V+A +S AD SL E K+ L E
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 569 -LFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYS 627
+D + + L Q + ++ V + R+ + ++ + AEEK +
Sbjct: 1413 LAYDKLEKTKNRL--QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 628 NKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRE-TSKHLEHK 686
+ K + L++ LE+ +E+ + +++L+A L++ ++ K++
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 687 DNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEE-ERKASTKIKEINVQ 745
+ R ++++ E +T+ +LE ++ + + +E + ++ + ER T+ E N +
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR-DEQNEE 1589
Query: 746 KAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIEL 805
K +L LIK L + D Q ++ K K+E D +Q+ + E+
Sbjct: 1590 KKRL------LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 806 DENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTL 865
+ ++L + K+ +R + ++ Q +++ L + ++
Sbjct: 1644 IKQLRKLQAQMKD-YQRELEEARASRDEIFAQSKESE---------KKLKSLEAEILQLQ 1693
Query: 866 DEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRE---NIS 922
+E L + ER+R +R+E +++T GK LD+ R I+
Sbjct: 1694 EE---LASSERARR-----------HAEQERDELADEITNSASGKSALLDEKRRLEARIA 1739
Query: 923 QVKERWLNPLKELVEKINEKF 943
Q++E L + +E +N++F
Sbjct: 1740 QLEEE-LEEEQSNMELLNDRF 1759
Score = 58.2 bits (139), Expect = 4e-08
Identities = 132/710 (18%), Positives = 278/710 (39%), Gaps = 98/710 (13%)
Query: 162 EEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREK 221
E K L+ QV L KV E +L ++EL E K L+N +
Sbjct: 1251 EHKRKKLDAQVQEL-----HAKVSEGDRL-RVELAEKASK-------------LQNELDN 1291
Query: 222 EKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQE 281
L ++K K E QD + + + L ++ E +++++
Sbjct: 1292 VSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351
Query: 282 YEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQK 341
EE + R ++++V L+ ++++ +LE K+ D + SQ+ ++K
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 342 QDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQ--PQ 399
++ +K LQQ L +LD QR++ + + + ++L E + + +
Sbjct: 1412 ALAYDKLEKTKNRLQQEL-DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470
Query: 400 IDAITNDLRRIQDEKALCEGEIIDKRRE-RETLEKEKKSVDDHIVRFDNLMNQKED---- 454
D + R ++ KAL +++ E +E E++ K + ++LM+ K+D
Sbjct: 1471 RDRAEAEARE-KETKALSLARALEEALEAKEEFERQNKQLR---ADMEDLMSSKDDVGKN 1526
Query: 455 --KLRQRFRDTYDAVLWLRNN----RDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSND 508
+L + R V +R D+ + + L +NM+ K A++ D
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK-AQF------ERD 1579
Query: 509 LRAFVFESQEDMEVFLKEVR-------DNKKLRVNAVIAPKSSYADKAPSRSLNELKQYG 561
L+ +++E + +K+VR D +K R AV + K D + E
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 562 FFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLK--QIYTAEEKY 619
+++L + Y +R ++E R +I+ ++
Sbjct: 1640 RDEVIKQLRKLQAQMKDY---------------------QRELEEARASRDEIFAQSKES 1678
Query: 620 VVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRET 679
K +++ L ++ RRH E++ E+ ++ SG AL +
Sbjct: 1679 EKKLKSLEAEILQLQEELASSE--------RARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 680 SKHLE------HKDNELRQKKKELLERKTKKRQLE-QKISSKLGSLKLMEQDTCN----L 728
+ LE ++ E Q ELL + +K L+ ++++L + + Q + N L
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 729 EEEERKASTKIKEI-NVQKAKLVTELTNLI----KICTSLHIQKVDLILQNTTVISEKNK 783
E + ++ K++E+ K+K ++ L ++ L + + N V + K
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 784 LESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQ 833
L+ +M + R +Q+ ++++ R+ Q ++L + + A +
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 85.9 bits (211), Expect = 2e-16
Identities = 173/872 (19%), Positives = 370/872 (42%), Gaps = 101/872 (11%)
Query: 151 INKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHK 210
+++K T +++++ A+N ++ N Q ++ E + I+ + ++ + + K
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQ-----EIYEKEEQFNIKQISEVQEKVNELKQFK 1554
Query: 211 YHCE-----LKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFY-ERKRHLDLIE 264
H + L+++ K +L +E E +Q M++ E K+ E ER + + +
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614
Query: 265 MLEAKRPWVEYENVRQEYEEVKLVRDRVKEE----VRKLKEGQIPVTCRIEEMENERHNL 320
+ AK E+ +EY+ +K+ +E + LKE +E +E E L
Sbjct: 1615 EIVAKMK----ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL 1670
Query: 321 EARIKEKATDIKEASQKCKQKQDVIE----RKDKHIEELQQALI--VKQNEEL------- 367
+ E +++ +++ + V E +D+ E L++ + +++ EEL
Sbjct: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
Query: 368 -DRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRR 426
+ Q I R ++ + NE+ + ++L+ DA+ +IQ+E + + +
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQ--KDLEHSNDALKAQDLKIQEELRIAHMHL---KE 1785
Query: 427 ERETLEKEKKSVDDHIVRFDNLMNQKED---KLRQRFRD---TYDAVLWLRNNRDKFKQR 480
++ET++K + V + + N+ E+ KL+++ ++ ++ L+ + ++ +++
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK 1845
Query: 481 VCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKK-----LRV 535
V E L +KD ++ + I + +L + E+ E+M+ +KE RDN + L++
Sbjct: 1846 VSEMEQLKKQIKD-QSLTLSKLEIENLNLAQKLHENLEEMKSVMKE-RDNLRRVEETLKL 1903
Query: 536 NAVIAPKSSYADKAPSRSLN-ELKQYGFFSYL-RELFDAPDPVMSYLCCQYHIHEVPVGT 593
+S KA + ELK S +E D +S Q I ++
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ--ISDIQKDL 1961
Query: 594 EKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRR 653
+K+++ +++ IQE + K++ K V S +K I+ LK QF + ++ R
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMS---HKKINEMEQLK-KQFEAQNLSMQSVR 2017
Query: 654 HLEEQL-KEIHRKLQAVDSGLIA-----LRETSKHLEHKDNELRQKKKELLERKTKKRQL 707
QL K++H L+ + ++A LR + L+ + ++ +E++ R + Q+
Sbjct: 2018 MDNFQLTKKLHESLEEIR--IVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQV 2075
Query: 708 --EQKISSKLGSLKLME--QDTCNLEEEERKASTKI---------------KEINVQKAK 748
E+++ S G L E ++ C+ +E K +++ KEI QK
Sbjct: 2076 KPEKRLLSD-GQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKEL 2134
Query: 749 LVTELTNL-IKICTSLHIQKVDLILQNTTV----ISEKNKLESDYMAASSQ-----LRLT 798
+ NL + + HI+K+ Q ++ I +K K Y+ + +
Sbjct: 2135 SMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF 2194
Query: 799 EQHFIELDENRQRLLQKCKELMKR----ARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSL 854
E FI+ E ++ LL K + L + +R++ +L Q + + + S+
Sbjct: 2195 EMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSI 2254
Query: 855 PMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVEL 914
FQ + + E+ L E + L I +E + + + E
Sbjct: 2255 KTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNES 2314
Query: 915 DQYRENISQVKERWLNPLKELVEKINEKFSNF 946
++ E + + + W LK L EK + F N+
Sbjct: 2315 TEFEERSATISKEWEQDLKSLKEKNEKLFKNY 2346
Score = 82.4 bits (202), Expect = 2e-15
Identities = 158/820 (19%), Positives = 346/820 (42%), Gaps = 114/820 (13%)
Query: 215 LKNLREKEKQLETSC--KEKTEYLQKMVQRNERYK-QDVERFYERKRHLDLIEMLEAKRP 271
L ++E + + E S KEK K+V E++K +D L L + L+
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 272 WVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVT--------------CRIEEMENER 317
E ++V +E ++++ +++ ++ E +LKE + C ++E E
Sbjct: 1436 --EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
Query: 318 HNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTR 377
+ L + EK T+I ++ + D ++ K + I E ++ +KQ E+ Q ++ +
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV--QEKVNELK 1551
Query: 378 KMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKS 437
+ E + + ++ E+ ++ +TN L+ Q+E + E + +R +E L+ E+
Sbjct: 1552 QFKEHRKAKDSALQSIES---KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608
Query: 438 VDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNK-N 496
+ ++ M + ++K Q + T AV ++ ++++CE L + K N
Sbjct: 1609 LKENTKEIVAKMKESQEKEYQFLKMT--AV-------NETQEKMCEIEHLKEQFETQKLN 1659
Query: 497 AKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNE 556
+ IE + L + E+ E+M KE RD+ + + + + +
Sbjct: 1660 LENIETE--NIRLTQILHENLEEMRSVTKE-RDDLRSVEETLKVERDQLKENLRETITRD 1716
Query: 557 LKQYG----FFSYLRELFDAPDPVMSYLCCQYH-IHEVPVGTEKTRERIE----RVIQET 607
L++ +L+E + D + + + + I + E + + ++ ++ +E
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
Query: 608 RLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQ 667
R+ ++ E++ + + S K + + DLE + +L+E ++L+
Sbjct: 1777 RIAHMHLKEQQETIDK-------LRGIVSEKTDKLSNMQKDLE---NSNAKLQEKIQELK 1826
Query: 668 AVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLE-------QKISSKLGSLK- 719
A + LI L++ + K +E+ Q KK++ ++ +LE QK+ L +K
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
Query: 720 -LMEQD-------TCNLEEEERKAS---TKIKEINVQKAKLVTELTNLIKICTSLHIQKV 768
+ E+D T LE ++ K S TK +++ +Q+ ++ + H + V
Sbjct: 1887 VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE------LKTARMLSKEHKETV 1940
Query: 769 DLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCN 828
D + + ISEK SD +LD+++ L +K +EL K+ Q+
Sbjct: 1941 DKLREK---ISEKTIQISDIQK-------------DLDKSKDELQKKIQELQKKELQLLR 1984
Query: 829 LGAEQTLPQEYQTQVPTIP---NGHNSSLPMVFQD-------LPNTLDEIDALLTEERSR 878
+ + + + ++ + N S+ V D L +L+EI + E
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044
Query: 879 ASCFTGLNPTIVQEYTKREEEI--EQLTEELKGKKVELDQYRENISQVKERWLNPLKELV 936
L Q E I ++ ++K +K L ++++++ + +KEL+
Sbjct: 2045 RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104
Query: 937 EKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVK 976
++ +E ++ +C + L E E ++ K + +RVK
Sbjct: 2105 KRYSEMDDHY----ECLNRLSLDLEKEIEFQK-ELSMRVK 2139
Score = 81.6 bits (200), Expect = 4e-15
Identities = 153/751 (20%), Positives = 322/751 (42%), Gaps = 81/751 (10%)
Query: 219 REKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENV 278
R+ +K E + L+ +V+ E Y QD+E K +E+L
Sbjct: 542 RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK-----VELL------------ 584
Query: 279 RQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKC 338
R++ +++K +++ + + +KL+ ++ ++ +E +E+ + + + + +
Sbjct: 585 REKEDQIKKLQEYI--DSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESA 642
Query: 339 KQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQP 398
+ + +E K+K ++EL +N+ Q ++ +KM DL+ EL++ N
Sbjct: 643 FLRSENLELKEK-MKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN------ 695
Query: 399 QIDAITNDLRRIQDEKALC----EGEIIDKRRERETLEKEKKSVDDHIVRFDNL--MNQK 452
+I +T+ + + LC EG+I D ++E +E +++ + ++ L + +
Sbjct: 696 EITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSE 755
Query: 453 EDKLRQRFRDTYDAVLWLRNNRDKF------KQRVCEPIMLTINMKDNKNAKYIENHIPS 506
++LR+ +D + + + + +DK K+ + ++ I K + +++ S
Sbjct: 756 VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG-KTKDDLATTQSNYKS 814
Query: 507 NDLRAFVFES-QEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSY 565
D F++ D E K V + + R+N I S A K S SL LK SY
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENE-RMNQEIVNLSKEAQKFDS-SLGALKTE--LSY 870
Query: 566 -LRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIER-------VIQETRLKQIYT-AE 616
+EL + V L + E + T + +ER +Q+T L+++ T +
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT-LEEVKTLTQ 929
Query: 617 EKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDL-EQRRHLEEQLKEIHRKLQAVDSGLIA 675
EK +K S ++ + + + +D EQ R+ E LK+ + + S +
Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE 989
Query: 676 LRETSKHLEHKDNELRQKKKELLERKTKKRQLE----QKISSKLGSLKLMEQD--TCNLE 729
+ H+E E + + ++ + KK+ LE Q +++ + +++EQ +L
Sbjct: 990 EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI 1049
Query: 730 EEERKASTKIKEINVQKAKLVTELTNLIKIC----TSLHIQKVDLILQNTTVISEKN--- 782
+E+ + ++ + +K +L T+L I++ L + +L Q V EKN
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAI 1109
Query: 783 KLESDYMAASSQLRLTEQHFIE----LDENRQRLLQKCKELMKRARQVCNLGAEQTLPQE 838
K E + +L E+ E L E +Q+LL +E+ + +++ + + L E
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI---ENLKNE 1166
Query: 839 YQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREE 898
+ + T+ + L + Q L +E+ + +T+ER T
Sbjct: 1167 LKNKELTLEHMETERLELA-QKLNENYEEVKS-ITKERKVLKELQKSFETERDHLRGYIR 1224
Query: 899 EIE----QLTEELKGKKVELDQYRENISQVK 925
EIE Q EELK + L +++E I +++
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Score = 70.1 bits (170), Expect = 1e-11
Identities = 143/770 (18%), Positives = 301/770 (39%), Gaps = 117/770 (15%)
Query: 224 QLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML--EAKRPWVEYENVRQE 281
+LE + + L K V+ NE +++V E K +E L E + E + E
Sbjct: 717 ELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSE 776
Query: 282 ----YEEVKLVRDRVK---EEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEA 334
+ EV RV+ EE+ K K+ + + E N + + K
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMV 836
Query: 335 SQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCE 394
++ ++ I K ++ +L + E + + + + +++ NE+ E
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM------E 890
Query: 395 NLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKED 454
L+ Q++ + L+ ++ EK L ++ E +TL +EK D + + + + D
Sbjct: 891 QLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK----DDLKQLQESLQIERD 946
Query: 455 KLRQRFRDTY----DAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLR 510
+L+ DT D LRN + KQ TIN +K ++ + ++ +
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQH-----QETINTLKSKISEEVSRNLHMEENT 1001
Query: 511 AFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNEL--KQYGFFSYLRE 568
+ + V + + +D + + A NE+ +Q FS ++E
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD----------NEIIEQQRKIFSLIQE 1051
Query: 569 LFDAPDPVMSYLC----CQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTS 624
+ + S + + + E T + +E + + E + +Q A+EK
Sbjct: 1052 KNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK------ 1105
Query: 625 FYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLE 684
N ++K L+ T D + +EE+LKE ++LQ L+ ++E ++
Sbjct: 1106 ---------NHAIKKEGELSRTCD--RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 685 HK-------DNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKAST 737
K NEL+ K+ L +T++ +L QK++ +K + ++ L+E ++ T
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFET 1214
Query: 738 KIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRL 797
+ + ++E+ + +L++
Sbjct: 1215 ERDHLR-----------------------------------GYIREIEATGLQTKEELKI 1239
Query: 798 TEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMV 857
H L E+++ + + + + ++ Q+ N + + Q ++P + + LP V
Sbjct: 1240 AHIH---LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVL-HEEQELLPNV 1295
Query: 858 --FQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELD 915
+ T++E++ LLTE+ + T I E + E+ ++ EE+K L
Sbjct: 1296 KEVSETQETMNELE-LLTEQSTTKDSTT--LARIEMERLRLNEKFQESQEEIK----SLT 1348
Query: 916 QYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEED 965
+ R+N+ +KE +L E I E + S Q E L+ + +++
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQES-QSKQEQSLNMKEKDN 1397
Score = 62.8 bits (151), Expect = 2e-09
Identities = 126/741 (17%), Positives = 307/741 (41%), Gaps = 101/741 (13%)
Query: 215 LKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVE 274
L++L++ ++ + T + +E + + + E + + F ++ +D + LEAK
Sbjct: 970 LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
Query: 275 YENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKA---TDI 331
+V+ + + E+ RK + I+E + LE+ I EK TD+
Sbjct: 1030 TADVKD---------NEIIEQQRK-------IFSLIQEKNELQQMLESVIAEKEQLKTDL 1073
Query: 332 KEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTE 391
KE + + Q+ + +++ Q+ + ++N + ++ + T + +++ +LK E
Sbjct: 1074 KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK--E 1131
Query: 392 NCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQ 451
+ LQ + + N +Q+E + E+ K E E L+ E K+ + + M
Sbjct: 1132 KSQQLQEKQQQLLN----VQEEMS----EMQKKINEIENLKNELKNKELTLEH----MET 1179
Query: 452 KEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRA 511
+ +L Q+ + Y+ V + R K+ + ++ +I ++ A
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKE---------LQKSFETERDHLRGYI--REIEA 1228
Query: 512 FVFESQEDMEVFLKEVRDNKKL--RVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLREL 569
+++E++++ ++++++ + ++ K++ + K L E
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE 1288
Query: 570 FDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNK 629
+ V Q ++E+ + TE++ + + ++++ E+ F ++
Sbjct: 1289 QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK-------FQESQ 1341
Query: 630 VISSNTSLKVAQFLTVTVDLEQRR-HLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDN 688
+ + + T+ LE + L+E ++E K+Q S +E S +++ KDN
Sbjct: 1342 EEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK----QEQSLNMKEKDN 1397
Query: 689 ELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAK 748
E + E+ + K K L + LG K +++ +E K+ K K+ ++Q+ +
Sbjct: 1398 ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQE-----SHDEMKSVAKEKD-DLQRLQ 1451
Query: 749 LV-----TELTNLIKICTSLHIQKVDLILQNTTVISEK----NKLESDYMAASSQLRLTE 799
V +L IK + H++ + + + E+ N+L + +++ +
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1511
Query: 800 QHFIELDENRQRLLQKC--KELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMV 857
+ +++ Q +Q+ KE +Q+ + + ++++ H +
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE--------HRKAKDSA 1563
Query: 858 FQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQY 917
Q + + + E+ L E + +Q K +EE++++ E L ++E DQ
Sbjct: 1564 LQSIESKMLELTNRLQESQEE-----------IQIMIKEKEEMKRVQEAL---QIERDQL 1609
Query: 918 RENISQVKERWLNPLKELVEK 938
+EN ++ + +KE EK
Sbjct: 1610 KENTKEIVAK----MKESQEK 1626
Score = 57.4 bits (137), Expect = 7e-08
Identities = 125/704 (17%), Positives = 295/704 (41%), Gaps = 77/704 (10%)
Query: 152 NKKSTTQKIVEEKVAALNIQV----GNLCQFLPQDK-VGEFAKLSKIELLEATEKSIGPP 206
+K S QK +E A L ++ N Q + K V E K K+ +E +K I
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK--KVSEMEQLKKQIKDQ 1859
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML 266
+ E++NL +K E E ++ +++ + ++ VE + +R +
Sbjct: 1860 SLTLSKLEIENLNLAQK-----LHENLEEMKSVMKERDNLRR-VEETLKLERDQLKESLQ 1913
Query: 267 EAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKE 326
E K +E ++QE + +++ KE V KL+E T +I +++ + + +++
Sbjct: 1914 ETKARDLE---IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970
Query: 327 KATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNE 386
K ++++ + + ++ + K I E++Q + + L Q + ++ + L
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 387 LKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFD 446
L+ + ++ I L+ +D+ E+I + R+ ++ EK+ + D
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
Query: 447 NLMNQKEDKLRQRFR------DTYDAVLWLRNNRDK---FKQRVCEPIMLTINMKDNKNA 497
+ +K ++++ + D Y+ + L + +K F++ + + +++
Sbjct: 2091 ESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSL-PYLQT 2149
Query: 498 KYIENHIPSNDLRAFVFES-QEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNE 556
K+IE +N + F + ++ L V K+ + ++ + + D+ +
Sbjct: 2150 KHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL 2209
Query: 557 LKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAE 616
+K +L++ D P + L K + ++ I+E + + ++
Sbjct: 2210 IK----IQHLQQDCDVPSRELRDL--------------KLNQNMDLHIEE--ILKDFSES 2249
Query: 617 EKYVVKTSFYSNKVISSNTSLK--VAQFLTVTVDLEQRRH-LEEQLKEIHRKLQAVDSGL 673
E +KT F +V+S+ + + ++L D+E+ ++ ++++ I + ++ +
Sbjct: 2250 EFPSIKTEF--QQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRI 2307
Query: 674 IALRETSKHLEHK----DNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLE 729
IA+ S E + E Q K L E+ K + Q + + L S + T +
Sbjct: 2308 IAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTT--QD 2365
Query: 730 EEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLE-SDY 788
+ +++ ++ +K + EL N SLH K + + + +I + +LE ++
Sbjct: 2366 NKNPHVTSRATQLTTEK---IRELEN------SLHEAKESAMHKESKIIKMQKELEVTND 2416
Query: 789 MAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAE 832
+ A Q ++ E + + L+K KE ++ + LGA+
Sbjct: 2417 IIAKLQAKVHESN---------KCLEKTKETIQVLQDKVALGAK 2451
Score = 42.7 bits (99), Expect = 0.002
Identities = 72/381 (18%), Positives = 149/381 (39%), Gaps = 40/381 (10%)
Query: 645 VTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK 704
+ +DL E K++ + L ++ + + S L ++ EL++K KEL T
Sbjct: 606 IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKEL---ATTY 662
Query: 705 RQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIK------------------EINVQK 746
+Q+E I L+ ++ +LE+E + A +I E+ +
Sbjct: 663 KQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKI 722
Query: 747 AKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRL----TEQHF 802
L EL ++ +L ++V L+ + ++ SE +L + S +L + ++ F
Sbjct: 723 TDLQKELNKEVEENEALR-EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 781
Query: 803 IELDENRQRLLQKCKELMKRARQVCNLGAE-QTLPQEYQTQVPTIPNGHNSSLPMVFQDL 861
E+ R+ +E+ K + + ++ QE+Q T+ MV ++
Sbjct: 782 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ-NFKTLHMDFEQKYKMVLEEN 840
Query: 862 PNTLDEIDALLTEERSRASCFTGLNPTI----------VQEYTKREEEIEQLTEELKGKK 911
EI L E + S L + +E +R E+EQL E+L+ +
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 912 VELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGI 971
L + + E+ L+E+ EK + +Q + +++ + +D +
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEK--DDLKQLQESLQIERDQLKSDIHDTVNM 958
Query: 972 RIRVKFRSSTQLHELTPHHQS 992
I + + L L H ++
Sbjct: 959 NIDTQEQLRNALESLKQHQET 979
Score = 40.4 bits (93), Expect = 0.009
Identities = 108/494 (21%), Positives = 201/494 (40%), Gaps = 73/494 (14%)
Query: 621 VKTSFYSNKVISSNT--SLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRE 678
+ S S + SNT +L ++ T L Q ++E +L + D + L
Sbjct: 461 IDESVCSESDVFSNTLDTLSEIEWNPATKLLNQE-NIESELNSLR-----ADYDNLVLDY 514
Query: 679 TSKHLEHKDNELRQKKK------ELLERKTKKRQLEQKISSKLGSLK-LMEQDTCNLEEE 731
E ++ EL+ K+K E LERKTKK Q E ++ ++ +LK L++ ++
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ-EMQLIHEISNLKNLVKHAEVYNQDL 573
Query: 732 ERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAA 791
E + S+K+ E+ +K + +L I L K+DL ++ K ++ + A
Sbjct: 574 ENELSSKV-ELLREKEDQIKKLQEYID-SQKLENIKMDLSYSLESIEDPKQMKQTLFDAE 631
Query: 792 SSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCN--------LGAEQTLPQEYQTQV 843
+ L + EN + L +K KEL +Q+ N L A++ + + + ++
Sbjct: 632 TVALDAKRESAFLRSENLE-LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
Query: 844 PTIPNGHNSSLPMVFQDLPNTL---DEIDALLTEERSRASCFTGLNPTIVQEYTKREE-- 898
+ N ++ +P L E++ +T+ + LN + + REE
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKE------LNKEVEENEALREEVI 744
Query: 899 ----------EIEQLTEELKGKKVEL----DQYRENISQV--KERWLNPLKELVEKINEK 942
E+E+L +E++ K EL + + S+V KE + L E + K +
Sbjct: 745 LLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDD 804
Query: 943 FSNFFSSMQCAGE-----VDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQ----SG 993
+ S+ + + LH + E+ KY + + R + ++ L+ Q S
Sbjct: 805 LATTQSNYKSTDQEFQNFKTLHMDFEQ---KYKMVLEENERMNQEIVNLSKEAQKFDSSL 861
Query: 994 GERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFIT 1053
G LQE R ++E+ Q + + R + + T +E T IT
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR---DSTLQTVEREKT----LIT 914
Query: 1054 PKLLQNLPYSEKMT 1067
KL Q L + +T
Sbjct: 915 EKLQQTLEEVKTLT 928
Score = 36.2 bits (82), Expect = 0.18
Identities = 47/184 (25%), Positives = 83/184 (45%), Gaps = 10/184 (5%)
Query: 218 LREKEKQLETSCKEKTEYLQKMVQRNER-YKQDVERFYERKRHLDLIEMLEAKRPWVEYE 276
+ E K LE + KE + LQ V + YK+++E + +DL +M AK E
Sbjct: 2425 VHESNKCLEKT-KETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEIS 2483
Query: 277 NVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQ 336
+ E K V ++E +R+ ++ Q T I E + + + + + I + ++
Sbjct: 2484 ATKATVEYQKEVIRLLRENLRRSQQAQ--DTSVISEHTDPQPSNKPLTCGGGSGIVQNTK 2541
Query: 337 KCKQKQDVIERKDKHIEELQQ---ALIVKQNEELDRQRRIGNTRKMIED--LQNELKTTE 391
K + I R +K I +L+Q LI ++NE L + + N K ++ L+ E
Sbjct: 2542 ALILKSEHI-RLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQV 2600
Query: 392 NCEN 395
CEN
Sbjct: 2601 TCEN 2604
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 84.3 bits (207), Expect = 6e-16
Identities = 157/807 (19%), Positives = 342/807 (42%), Gaps = 110/807 (13%)
Query: 162 EEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREK 221
E++VA L +++ L + L ++KV +L L+ T++ + + K LRE
Sbjct: 452 EQQVADLQLKLSRLEEQL-KEKVTNSTELQ--HQLDKTKQQHQEQQALQQSTTAK-LREA 507
Query: 222 EKQLETSCKE---KTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENV 278
+ LE ++ K + +Q + ++ K+++ E++R DL ++A N
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS-LLEKERE-DLYAKIQAGEGETAVLNQ 565
Query: 279 RQE-----YEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKE 333
QE E+V + +++K + K+ Q + +++E + + R+ T + E
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 334 ASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENC 393
+ + + ++ + + D I+ + L+ + + ++ DLQN L T +N
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA----------DLQNHLDTAQNA 675
Query: 394 -ENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQK 452
++ Q +++ IT L ++ ++ DK+ LE K + + + +
Sbjct: 676 LQDKQQELNKITTQLDQVT-------AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 453 EDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAF 512
E ++++ D+ + ++ ++++ Q + + L ++ +LRA
Sbjct: 729 EGQIKKLEADSLE----VKASKEQALQDLQQQRQLNTDL----------------ELRAT 768
Query: 513 VFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDA 572
Q +ME KE+ + +L + K S A ++ + L KQ L++ F+
Sbjct: 769 ELSKQLEME---KEIVSSTRLDLQ-----KKSEALESIKQKLT--KQEEEKQILKQDFET 818
Query: 573 PDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVIS 632
E + E+ RI+ + T L+++ +E + + S +K+
Sbjct: 819 LS------------QETKIQHEELNNRIQTTV--TELQKVKMEKEALMTELSTVKDKLSK 864
Query: 633 SNTSLKVAQFLTVTVDLEQRR---HLEEQLKEIHRKLQA-VDSGLIALRETSKHLEHKDN 688
+ SLK ++ + + + LE+ KE+ +LQ +++ L +E K LE +
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 689 -------ELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
EL +++L++ + +Q E++ G++ ++Q + +++ ++K
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 742 INVQKAKLVTELTN-LIKICTSLHIQKVDL-ILQNTTVISEKN--KLESDYMAASSQLRL 797
+QK +L +L L + L +K + +LQN S++ +L+SD+ S+L
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 798 TEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMV 857
T Q ++E +L ++L+ Q+ G + L QE +T T+ +
Sbjct: 1045 TRQDLKSVEE---KLSLAQEDLISNRNQI---GNQNKLIQELKTAKATLEQDSAKKEQQL 1098
Query: 858 ------FQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKK 911
QD+ + L E+S+ + I + ++E+EI +L EELK K
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLA-------EIEEIKCRQEKEITKLNEELKSHK 1151
Query: 912 VELDQYRENISQVKERWLNPLKELVEK 938
+E + N+ K+ + EL K
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGK 1178
Score = 70.1 bits (170), Expect = 1e-11
Identities = 146/819 (17%), Positives = 320/819 (39%), Gaps = 113/819 (13%)
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLD----- 261
E K E K L+ + E + + L K Q Y Q++++ L
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 262 LIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLE 321
L E L K +Y + +++ E + + ++ + + + R+ E H +
Sbjct: 307 LTENLLKKEQ--DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
Query: 322 ARIKEKATDIKEASQKCKQKQDVIERKDKHIE----ELQQALIVKQNEELDRQRRIGNTR 377
+ EK EA+QK K++ +E K +H++ +LQQ K+ L Q I
Sbjct: 365 VELSEKG----EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 378 KMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKS 437
+ + + +L R+++++ L +++DK ++ L+ +
Sbjct: 421 SKLLETERQLGEAHG----------------RLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 438 VDDHI---VRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDN 494
+++ + V + + DK +Q+ ++ A+ + + Q E ++ I KD
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQ-QALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
Query: 495 KNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRD---------------NKKLRVNAVI 539
K I+N L A + +S+E++ + KE D N+ N +
Sbjct: 524 K----IQN------LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
Query: 540 APK-SSYADKAPSRSLNELK-QYGFFSYLRE----LFDAPDPVMSYLCCQYHIHEVPVGT 593
+ + +K ++S + + Q ++E L A D V+S + ++E+
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL---ETSVNELNSQL 630
Query: 594 EKTRERIERVIQETRLKQ--IYTAEEKYVVKTSFYSNKVISSNTSLK---------VAQF 642
+++E++ ++ + + K + +AE + + N + ++ +L+ Q
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 690
Query: 643 LTVTVDLEQRRH----LEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELL 698
VT L+ ++ LE LKE K +++ L K LE E++ K++ L
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 699 ERKTKKRQL-----------------EQKISS--------KLGSLKLMEQDTCNLEEEER 733
+ ++RQL E++I S K +L+ ++Q EEE++
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Query: 734 KASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASS 793
+ ++ + EL N I+ T +QKV + + +++E + ++ S
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQT-TVTELQKVKM--EKEALMTELSTVKDKLSKVSD 867
Query: 794 QLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNS- 852
L+ ++ F + ++ + + ++ K + + E TL ++ + + S
Sbjct: 868 SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927
Query: 853 SLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKV 912
L + + L + L + G + Q +++++IE L ELK +
Sbjct: 928 QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
Query: 913 ELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQ 951
+ + + Q + L EKI+ +N+ S +
Sbjct: 988 QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Score = 69.7 bits (169), Expect = 1e-11
Identities = 137/739 (18%), Positives = 308/739 (41%), Gaps = 93/739 (12%)
Query: 218 LREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYEN 277
LR++ + L+ S KE+ Y +++ + E+Y Q ++
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKY-QGLQ-------------------------- 120
Query: 278 VRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEAR---IKEKATDIKEA 334
+QE + LV D E++ L++ ++EE + E N++ ++KA +
Sbjct: 121 -QQEAKPDGLVTDS-SAELQSLEQ-------QLEEAQTENFNIKQMKDLFEQKAAQLATE 171
Query: 335 SQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCE 394
K K D +++ + E + + + EEL+++ + I+DL+ EL E
Sbjct: 172 IADIKSKYD----EERSLREAAEQKVTRLTEELNKEATV------IQDLKTELLQRPGIE 221
Query: 395 NLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKED 454
+ + + +L ++Q L + +++ RE E L+ E K + + ++Q
Sbjct: 222 D----VAVLKKELVQVQ---TLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 455 KLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINM--KDNKNAKYIENH----IPSND 508
+L + ++ V L+ + + + LT N+ K+ K E H + +
Sbjct: 275 ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKN 334
Query: 509 LRAFVFESQEDMEVFLKEV--RDNKKLRVNAVIAPKSSYADKAPSR-SLNELKQYGFFSY 565
++A + + D + + + R++ ++ K K S E K +
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE 394
Query: 566 LRELFDAPDPVMSY-LCCQYHIHEVPVGTEKTRERIERVIQETRLK-QIYTAEEKYVVKT 623
++L + + L Q I+++ +T ++ RLK Q + EK + K
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA--HGRLKEQRQLSSEKLMDKE 452
Query: 624 SFYSNKVIS-SNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKH 682
++ + S ++ + +T + +L+ H ++ K+ H++ QA+ + T+
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQ---HQLDKTKQQHQEQQALQ------QSTTAK 503
Query: 683 LEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNL------EEEERKAS 736
L N+L Q +++ ++ K + LE + ++ L+E++ +L E E
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 737 TKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLR 796
+++E N + VT+LT +K + H Q + + + V +K L + S
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL--HDQVQEQKAHLRAAQDRVLSLET 621
Query: 797 LTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQ-EYQTQVPTIPNGHNSSLP 855
+ +L+E+++++ Q ++ + + + A +T + + Q + T N
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-Q 680
Query: 856 MVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELD 915
+ LD++ A L +++ S + ++EY ++ +EQ TEEL+G+ +L+
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQL----ESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 916 QYRENISQVKERWLNPLKE 934
+ KE+ L L++
Sbjct: 737 ADSLEVKASKEQALQDLQQ 755
Score = 68.6 bits (166), Expect = 3e-11
Identities = 148/784 (18%), Positives = 311/784 (39%), Gaps = 73/784 (9%)
Query: 151 INKKSTTQKIVEEKVAALNIQVGNLCQF--LPQDKVGEFAKLSKIELLEATEKSIG-PPE 207
+N+ ++E+V L ++ N + Q+ + + + K L A ++ +
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 208 MHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLE 267
+++ + +L +EK QL+ K KTE L + D++ + ++ + E
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 268 AKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEK 327
+ + + V + ++ + +++ +++ KE + + + EE+E + LEA E
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 328 ATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNEL 387
++A Q +Q++ + + EL + L +++ + + + +E ++ +L
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 388 KTTENCENLQPQIDAITNDLRRIQDEK-----ALCEGEIIDKRRERETLEKEKKSVDDHI 442
E + + Q + +IQ E+ E+ + E+E L E +V D +
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 443 VRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIEN 502
+ + + + + + + A+L L + K ++ + T+ + +
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 503 HIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGF 562
S+ L+ + QE + ++ N+K ++ ++NELKQ
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEK-------------EEQQLQGNINELKQSS- 968
Query: 563 FSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVK 622
++ +A + Q KT + Q T+ Q AE++ K
Sbjct: 969 -EQKKKQIEALQGELKIAVLQ-----------KTELENKLQQQLTQAAQELAAEKE---K 1013
Query: 623 TSFYSNKVISSNTSLKVAQ--FLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETS 680
S N S + K Q F +L R + LK + KL LI+ R
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATR---QDLKSVEEKLSLAQEDLISNR--- 1067
Query: 681 KHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCN-LEEEERKASTKI 739
N++ + K + E KT K LEQ + K L Q+ C L++ +++ S K
Sbjct: 1068 -------NQIGNQNKLIQELKTAKATLEQDSAKKEQQL----QERCKALQDIQKEKSLKE 1116
Query: 740 KEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLES--DYMAASSQLRL 797
KE+ +K+KL IK I K++ L++ +KLES + +L
Sbjct: 1117 KELVNEKSKLAE--IEEIKCRQEKEITKLNEELKS-------HKLESIKEITNLKDAKQL 1167
Query: 798 TEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMV 857
Q +EL + + L+ E KR +Q+ +Q +E + + I +
Sbjct: 1168 LIQQKLEL-QGKADSLKAAVEQEKRNQQILK---DQVKKEEEELKKEFIEKEAKLHSEIK 1223
Query: 858 FQDL-PNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQ 916
+++ +E +A LT + + + G Q +R E+E+ T++L+G+ L+
Sbjct: 1224 EKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEA 1283
Query: 917 YREN 920
+N
Sbjct: 1284 TVQN 1287
Score = 46.6 bits (109), Expect = 1e-04
Identities = 83/376 (22%), Positives = 150/376 (39%), Gaps = 49/376 (13%)
Query: 597 RERIERVIQETRLKQIYTAEEKYV--VKTSFYSNKVISSNTSLKV----AQFLTVTVDLE 650
RE E+ + TRL + E + +KT I LK Q L + LE
Sbjct: 186 REAAEQKV--TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 243
Query: 651 QRRHLEEQLKEIHRKLQA-VDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQ 709
+ R E+LK+ +KLQ+ S + + L E+ +EL + K+ +L Q
Sbjct: 244 RERE-SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
Query: 710 KISSKLGSLKLMEQDTCNLEEEERKASTKIKEINV---QKAKLVTELTNLIKIC-TSLHI 765
K + +L EQD LEE+ + S K I QK +L + + TSLH
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 766 QKVDLILQN----------TTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQK 815
V+L + + V ++ L++++ Q EQH ++L +L K
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 816 CKELMK-------RARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEI 868
E + R ++ L +E+ + +E Q DL L +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV-----------------ADLQLKLSRL 465
Query: 869 DALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERW 928
+ L E+ + ++ Q++ +++ + T +L+ + +L+Q I K++
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD-KDQK 524
Query: 929 LNPLKELVEKINEKFS 944
+ L+ L++K E S
Sbjct: 525 IQNLEALLQKSKENIS 540
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 83.6 bits (205), Expect = 1e-15
Identities = 176/968 (18%), Positives = 382/968 (39%), Gaps = 130/968 (13%)
Query: 53 IVRISMENFLTY-DICEVSP-GPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKV 110
I I +E F +Y EV+ P N I G NG+GKS+I+ +IC L RA +
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 111 GFFVKRGCSRGMVEIEL---------------FRASGNLVITREIDVAKNQSFWFINKKS 155
V + G+ + + F + +TR++ V ++ + IN +
Sbjct: 63 QDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQV-VIGGRNKYLINGVN 121
Query: 156 TTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYH--C 213
V++ ++ + V N + Q ++ + + E+L E++ G M++Y
Sbjct: 122 ANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAG-TRMYEYKKIA 180
Query: 214 ELKNLREKE---KQLETSCKEK-TEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K + +KE K+++T +E+ T +QK+ + Y + + + R ++ + L
Sbjct: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLE----YQKVMREIEHLSRLYIA 236
Query: 270 RPWVEYENVR-QEYEEVKLVRDRVKEEVRKLKEGQIPVTC---RIEEMENERHNLEARIK 325
++ E+ + + EE+K ++D+V + +L E + IEE+E + I
Sbjct: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGIL 296
Query: 326 EKATD-IKEASQKCKQKQDVIERKDKHI-------EELQQALIVKQNEELDRQRRIGNTR 377
D + EA + + Q + K K++ +EL++ ++ +++ +
Sbjct: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
Query: 378 KMIEDLQN-ELKTTENCENLQPQIDAITNDLRRIQD-EKALCEGEIIDKRRERETLEKEK 435
+ LQ K E Q +A++ L +D +A G+++ + + + E
Sbjct: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
Query: 436 KSVDDHIVRFDNLMNQKE---DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMK 492
K + + K+ K+ +R +A+ ++ ++K E M +N +
Sbjct: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKL-----EAEMKKLNYE 471
Query: 493 DNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSR 552
+NK +E L + +E E L P +A K P +
Sbjct: 472 ENKEESLLEKR---RQLSRDIGRLKETYEALLARF-------------PNLRFAYKDPEK 515
Query: 553 SLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
+ N G + L + D L ++ V V TE T +++ ++ LK+
Sbjct: 516 NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRR 572
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
YT ++ + S + I+ T L+VAQ L ++ L E E+ + ++ V
Sbjct: 573 YT-----IIPLNKISARCIAPET-LRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT 626
Query: 673 LIAL--RETSKHLEHKDNEL---------------------RQKKKELLERKTKKRQLEQ 709
+ +K + + R + +L + + + ++
Sbjct: 627 TFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
Query: 710 KISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKI---CTSLHIQ 766
++ K L+ +E++ L + + K +++ Q+ ++ TE +L++ +S H Q
Sbjct: 687 ELRIKENELRALEEELAGL----KNTAEKYRQLK-QQWEMKTEEADLLQTKLQQSSYHKQ 741
Query: 767 KVDLILQNTTVISEKNKLESD---YMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRA 823
+ +L T+ + L++ A + + E + R+R L+ ++ + A
Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801
Query: 824 RQVCNLGAEQTLPQEYQTQVPTIP--------NGHNSSLPMVFQDLPNTLDEIDALLTEE 875
+ + +++ ++ + + T+ + L V + + + +I+ + E
Sbjct: 802 KTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV 861
Query: 876 RSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRE--NISQVKERWLNPLK 933
+E TK++E I +K K E+ +++E N SQ+K +K
Sbjct: 862 AKNKESVNKAQ----EEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLK------IK 911
Query: 934 ELVEKINE 941
EL I++
Sbjct: 912 ELDHNISK 919
Score = 46.2 bits (108), Expect = 2e-04
Identities = 96/517 (18%), Positives = 204/517 (39%), Gaps = 69/517 (13%)
Query: 524 LKEVRDNKKLRVNAVIAPKSSYAD-KAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCC 582
LK+V+D +++ N + A + A K + +LKQ + E D +
Sbjct: 681 LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQ--WEMKTEEADLLQTKLQQ--S 736
Query: 583 QYHIHEVPVGT-EKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQ 641
YH + + +KT E E ++ T+ Q AEEKY V + N
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQ-RKAEEKYEVLENKMKN------------- 782
Query: 642 FLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERK 701
+ E+ R L++ K++ D+ ++E + +E EL + K+E K
Sbjct: 783 -----AEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
Query: 702 TKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICT 761
+ + + I S +++M + +E KA +E+ QK + +
Sbjct: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQ---EEVTKQKEVITAQ--------- 885
Query: 762 SLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMK 821
D +++ K+K +++ SQL++ E + ++++ ++ K
Sbjct: 886 -------DTVIKAKYAEVAKHKEQNN----DSQLKIKELDH-NISKHKREAEDGAAKVSK 933
Query: 822 RARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASC 881
+ + AE+ L + P ++ P L E + E+ R
Sbjct: 934 MLKDYDWINAERHLFGQ-----PNSAYDFKTNNPKEAGQRLQKLQE----MKEKLGRNVN 984
Query: 882 FTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINE 941
+N ++ E +R ++ + ++ K ++ E++ Q K + LN + K+N+
Sbjct: 985 MRAMN--VLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ---KVNK 1039
Query: 942 KFSNFFSSMQCAGEVDLHT-ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVST 1000
F + FS++ L E + D ++ + L EL SGG+RS+
Sbjct: 1040 DFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTEL-----SGGQRSLVA 1094
Query: 1001 MLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMV 1037
+ ++++ P ++DE++ +D + + + +M+
Sbjct: 1095 LSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQML 1131
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 83.6 bits (205), Expect = 1e-15
Identities = 176/968 (18%), Positives = 382/968 (39%), Gaps = 130/968 (13%)
Query: 53 IVRISMENFLTY-DICEVSP-GPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKV 110
I I +E F +Y EV+ P N I G NG+GKS+I+ +IC L RA +
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 111 GFFVKRGCSRGMVEIEL---------------FRASGNLVITREIDVAKNQSFWFINKKS 155
V + G+ + + F + +TR++ V ++ + IN +
Sbjct: 63 QDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQV-VIGGRNKYLINGVN 121
Query: 156 TTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYH--C 213
V++ ++ + V N + Q ++ + + E+L E++ G M++Y
Sbjct: 122 ANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAG-TRMYEYKKIA 180
Query: 214 ELKNLREKE---KQLETSCKEK-TEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K + +KE K+++T +E+ T +QK+ + Y + + + R ++ + L
Sbjct: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLE----YQKVMREIEHLSRLYIA 236
Query: 270 RPWVEYENVR-QEYEEVKLVRDRVKEEVRKLKEGQIPVTC---RIEEMENERHNLEARIK 325
++ E+ + + EE+K ++D+V + +L E + IEE+E + I
Sbjct: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGIL 296
Query: 326 EKATD-IKEASQKCKQKQDVIERKDKHI-------EELQQALIVKQNEELDRQRRIGNTR 377
D + EA + + Q + K K++ +EL++ ++ +++ +
Sbjct: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
Query: 378 KMIEDLQN-ELKTTENCENLQPQIDAITNDLRRIQD-EKALCEGEIIDKRRERETLEKEK 435
+ LQ K E Q +A++ L +D +A G+++ + + + E
Sbjct: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
Query: 436 KSVDDHIVRFDNLMNQKE---DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMK 492
K + + K+ K+ +R +A+ ++ ++K E M +N +
Sbjct: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKL-----EAEMKKLNYE 471
Query: 493 DNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSR 552
+NK +E L + +E E L P +A K P +
Sbjct: 472 ENKEESLLEKR---RQLSRDIGRLKETYEALLARF-------------PNLRFAYKDPEK 515
Query: 553 SLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
+ N G + L + D L ++ V V TE T +++ ++ LK+
Sbjct: 516 NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRR 572
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
YT ++ + S + I+ T L+VAQ L ++ L E E+ + ++ V
Sbjct: 573 YT-----IIPLNKISARCIAPET-LRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT 626
Query: 673 LIAL--RETSKHLEHKDNEL---------------------RQKKKELLERKTKKRQLEQ 709
+ +K + + R + +L + + + ++
Sbjct: 627 TFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
Query: 710 KISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKI---CTSLHIQ 766
++ K L+ +E++ L + + K +++ Q+ ++ TE +L++ +S H Q
Sbjct: 687 ELRIKENELRALEEELAGL----KNTAEKYRQLK-QQWEMKTEEADLLQTKLQQSSYHKQ 741
Query: 767 KVDLILQNTTVISEKNKLESD---YMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRA 823
+ +L T+ + L++ A + + E + R+R L+ ++ + A
Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801
Query: 824 RQVCNLGAEQTLPQEYQTQVPTIP--------NGHNSSLPMVFQDLPNTLDEIDALLTEE 875
+ + +++ ++ + + T+ + L V + + + +I+ + E
Sbjct: 802 KTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV 861
Query: 876 RSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRE--NISQVKERWLNPLK 933
+E TK++E I +K K E+ +++E N SQ+K +K
Sbjct: 862 AKNKESVNKAQ----EEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLK------IK 911
Query: 934 ELVEKINE 941
EL I++
Sbjct: 912 ELDHNISK 919
Score = 46.2 bits (108), Expect = 2e-04
Identities = 96/517 (18%), Positives = 204/517 (39%), Gaps = 69/517 (13%)
Query: 524 LKEVRDNKKLRVNAVIAPKSSYAD-KAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCC 582
LK+V+D +++ N + A + A K + +LKQ + E D +
Sbjct: 681 LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQ--WEMKTEEADLLQTKLQQ--S 736
Query: 583 QYHIHEVPVGT-EKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQ 641
YH + + +KT E E ++ T+ Q AEEKY V + N
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQ-RKAEEKYEVLENKMKN------------- 782
Query: 642 FLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERK 701
+ E+ R L++ K++ D+ ++E + +E EL + K+E K
Sbjct: 783 -----AEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
Query: 702 TKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICT 761
+ + + I S +++M + +E KA +E+ QK + +
Sbjct: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQ---EEVTKQKEVITAQ--------- 885
Query: 762 SLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMK 821
D +++ K+K +++ SQL++ E + ++++ ++ K
Sbjct: 886 -------DTVIKAKYAEVAKHKEQNN----DSQLKIKELDH-NISKHKREAEDGAAKVSK 933
Query: 822 RARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASC 881
+ + AE+ L + P ++ P L E + E+ R
Sbjct: 934 MLKDYDWINAERHLFGQ-----PNSAYDFKTNNPKEAGQRLQKLQE----MKEKLGRNVN 984
Query: 882 FTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINE 941
+N ++ E +R ++ + ++ K ++ E++ Q K + LN + K+N+
Sbjct: 985 MRAMN--VLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ---KVNK 1039
Query: 942 KFSNFFSSMQCAGEVDLHT-ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVST 1000
F + FS++ L E + D ++ + L EL SGG+RS+
Sbjct: 1040 DFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTEL-----SGGQRSLVA 1094
Query: 1001 MLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMV 1037
+ ++++ P ++DE++ +D + + + +M+
Sbjct: 1095 LSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQML 1131
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 83.6 bits (205), Expect = 1e-15
Identities = 176/968 (18%), Positives = 382/968 (39%), Gaps = 130/968 (13%)
Query: 53 IVRISMENFLTY-DICEVSP-GPHLNMIVGANGTGKSSIVCAICLGLAGKPAFMGRADKV 110
I I +E F +Y EV+ P N I G NG+GKS+I+ +IC L RA +
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 111 GFFVKRGCSRGMVEIEL---------------FRASGNLVITREIDVAKNQSFWFINKKS 155
V + G+ + + F + +TR++ V ++ + IN +
Sbjct: 63 QDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQV-VIGGRNKYLINGVN 121
Query: 156 TTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYH--C 213
V++ ++ + V N + Q ++ + + E+L E++ G M++Y
Sbjct: 122 ANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAG-TRMYEYKKIA 180
Query: 214 ELKNLREKE---KQLETSCKEK-TEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K + +KE K+++T +E+ T +QK+ + Y + + + R ++ + L
Sbjct: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLE----YQKVMREIEHLSRLYIA 236
Query: 270 RPWVEYENVR-QEYEEVKLVRDRVKEEVRKLKEGQIPVTC---RIEEMENERHNLEARIK 325
++ E+ + + EE+K ++D+V + +L E + IEE+E + I
Sbjct: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGIL 296
Query: 326 EKATD-IKEASQKCKQKQDVIERKDKHI-------EELQQALIVKQNEELDRQRRIGNTR 377
D + EA + + Q + K K++ +EL++ ++ +++ +
Sbjct: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
Query: 378 KMIEDLQN-ELKTTENCENLQPQIDAITNDLRRIQD-EKALCEGEIIDKRRERETLEKEK 435
+ LQ K E Q +A++ L +D +A G+++ + + + E
Sbjct: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
Query: 436 KSVDDHIVRFDNLMNQKE---DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMK 492
K + + K+ K+ +R +A+ ++ ++K E M +N +
Sbjct: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKL-----EAEMKKLNYE 471
Query: 493 DNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSR 552
+NK +E L + +E E L P +A K P +
Sbjct: 472 ENKEESLLEKR---RQLSRDIGRLKETYEALLARF-------------PNLRFAYKDPEK 515
Query: 553 SLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
+ N G + L + D L ++ V V TE T +++ ++ LK+
Sbjct: 516 NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRR 572
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
YT ++ + S + I+ T L+VAQ L ++ L E E+ + ++ V
Sbjct: 573 YT-----IIPLNKISARCIAPET-LRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT 626
Query: 673 LIAL--RETSKHLEHKDNEL---------------------RQKKKELLERKTKKRQLEQ 709
+ +K + + R + +L + + + ++
Sbjct: 627 TFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
Query: 710 KISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKI---CTSLHIQ 766
++ K L+ +E++ L + + K +++ Q+ ++ TE +L++ +S H Q
Sbjct: 687 ELRIKENELRALEEELAGL----KNTAEKYRQLK-QQWEMKTEEADLLQTKLQQSSYHKQ 741
Query: 767 KVDLILQNTTVISEKNKLESD---YMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRA 823
+ +L T+ + L++ A + + E + R+R L+ ++ + A
Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801
Query: 824 RQVCNLGAEQTLPQEYQTQVPTIP--------NGHNSSLPMVFQDLPNTLDEIDALLTEE 875
+ + +++ ++ + + T+ + L V + + + +I+ + E
Sbjct: 802 KTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV 861
Query: 876 RSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRE--NISQVKERWLNPLK 933
+E TK++E I +K K E+ +++E N SQ+K +K
Sbjct: 862 AKNKESVNKAQ----EEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLK------IK 911
Query: 934 ELVEKINE 941
EL I++
Sbjct: 912 ELDHNISK 919
Score = 46.2 bits (108), Expect = 2e-04
Identities = 96/517 (18%), Positives = 204/517 (39%), Gaps = 69/517 (13%)
Query: 524 LKEVRDNKKLRVNAVIAPKSSYAD-KAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCC 582
LK+V+D +++ N + A + A K + +LKQ + E D +
Sbjct: 681 LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQ--WEMKTEEADLLQTKLQQ--S 736
Query: 583 QYHIHEVPVGT-EKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQ 641
YH + + +KT E E ++ T+ Q AEEKY V + N
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQ-RKAEEKYEVLENKMKN------------- 782
Query: 642 FLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERK 701
+ E+ R L++ K++ D+ ++E + +E EL + K+E K
Sbjct: 783 -----AEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
Query: 702 TKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICT 761
+ + + I S +++M + +E KA +E+ QK + +
Sbjct: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQ---EEVTKQKEVITAQ--------- 885
Query: 762 SLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMK 821
D +++ K+K +++ SQL++ E + ++++ ++ K
Sbjct: 886 -------DTVIKAKYAEVAKHKEQNN----DSQLKIKELDH-NISKHKREAEDGAAKVSK 933
Query: 822 RARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASC 881
+ + AE+ L + P ++ P L E + E+ R
Sbjct: 934 MLKDYDWINAERHLFGQ-----PNSAYDFKTNNPKEAGQRLQKLQE----MKEKLGRNVN 984
Query: 882 FTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINE 941
+N ++ E +R ++ + ++ K ++ E++ Q K + LN + K+N+
Sbjct: 985 MRAMN--VLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ---KVNK 1039
Query: 942 KFSNFFSSMQCAGEVDLHT-ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVST 1000
F + FS++ L E + D ++ + L EL SGG+RS+
Sbjct: 1040 DFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTEL-----SGGQRSLVA 1094
Query: 1001 MLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMV 1037
+ ++++ P ++DE++ +D + + + +M+
Sbjct: 1095 LSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQML 1131
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 80.1 bits (196), Expect = 1e-14
Identities = 154/842 (18%), Positives = 348/842 (41%), Gaps = 114/842 (13%)
Query: 151 INKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHK 210
IN + + EK+A ++ NL K E KLS++ L + E + E
Sbjct: 760 INTMTQDLRGANEKLAVAEVRAENL------KKEKEMLKLSEVRLSQQRESLLA--EQRG 811
Query: 211 YHCELKNLREKEKQLETSCKEKTEYLQKMVQRNE--------RYKQDVERFYERKRHLDL 262
+ L NL+ + LE S E + L +++ E + + +VE+ + R+LD
Sbjct: 812 QNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLD- 870
Query: 263 IEMLEAKRPWVEYENVRQEYEEVKLVRDRVKE-----------EVRKL------------ 299
+++L+ KR N+ +E L+++ KE EV+
Sbjct: 871 VQLLDTKRQLDTETNLHLNTKE--LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQP 928
Query: 300 --KEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQ 357
KE + ++ + E + ++L+ R+K +++++ ++ + ++ + EE+++
Sbjct: 929 SNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
Query: 358 ALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTEN--CENLQPQIDAITNDLRRIQDE-- 413
+ V+ E + Q ++ +E + EL+ + E+++ Q+ + L +Q+E
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQ 1048
Query: 414 KALCEGEII---DKRRERETLEKEKKSVDDHIVRFDNLMNQKED-KLRQRFRDTYDAVLW 469
+AL +++ R+ E+ K +V+ LM D + Q ++ +
Sbjct: 1049 EALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMAS 1108
Query: 470 LRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQ-----EDMEVFL 524
+R + ++ Q+ E +L + + +++ + R E Q + +E
Sbjct: 1109 VRQHLEETTQKA-ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 525 KEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQY 584
+V + K V + S K+ + L L+ F +E+ + V +Y
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIAETRFEVAQVESLRY 1224
Query: 585 HIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLT 644
+ E +ER +QE + E+ V + ++ + T T
Sbjct: 1225 R---------QRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMET 1275
Query: 645 VTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK 704
+ E++ LE+ L+++ K++ ++ ++ L+E + L K L Q +K+LLE K+
Sbjct: 1276 NKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGML-QAEKKLLEEDVKR 1334
Query: 705 RQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLH 764
K + L+ Q EE RK ++ KE++ ++ + +TE +
Sbjct: 1335 --------WKARNQHLVSQQKDPDTEEYRKLLSE-KEVHTKRIQQLTEEIGRL------- 1378
Query: 765 IQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELD--------ENRQRLLQKC 816
K ++ N ++ + +N ++S + TE+ I+ D + + + + +
Sbjct: 1379 --KAEIARSNASLTNNQNLIQS--LKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQV 1434
Query: 817 KELMKRAR-QVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEE 875
K++ +R + Q L A+Q E Q +G + + Q++ + ++ T+
Sbjct: 1435 KKIGRRYKTQYEELKAQQDKVMETSAQ----SSGDHQEQHVSVQEMQELKETLNQAETKS 1490
Query: 876 RSRASCFTGLNPTIVQEYTKR----------EEEIEQLTEELKGKKVELDQYRENISQVK 925
+S S L T+ ++ T+ + E+ +L ++L+ + + +Q R+ I++ +
Sbjct: 1491 KSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE 1550
Query: 926 ER 927
E+
Sbjct: 1551 EK 1552
Score = 63.2 bits (152), Expect = 1e-09
Identities = 103/547 (18%), Positives = 226/547 (41%), Gaps = 74/547 (13%)
Query: 312 EMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKD---KHIEELQQALIVKQNEELD 368
E E + +E R+ + +++C+ + +E+ + K + E + L + Q+ +
Sbjct: 49 ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108
Query: 369 RQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQD---EKALCEGEI---- 421
Q + T++ +E + +L T E L +++ +T D++R+ + E +GE+
Sbjct: 109 IQSQFTRTKEELEAEKRDLIRTN--ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166
Query: 422 -------IDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNR 474
+ + + LE+EK+ + + + K D+L R+ + +L L+ N
Sbjct: 167 DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNL 226
Query: 475 DKFKQRVCEPIMLTINMKDNKNA-KYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKL 533
+ K+ V L M K + ++++ H+ DL + E++E ++ +
Sbjct: 227 ENKKEEVSR---LEEQMNGLKTSNEHLQKHV--EDLLTKLKEAKEQQASMEEKFHNELNA 281
Query: 534 RVNAVIAPKSSYADKAPSRSLNELKQ--YGFFSYLRELFDAPDPVMSYLC--------CQ 583
+ KS+ AD + ++S NEL + L+E +A + +L +
Sbjct: 282 HIKLSNLYKSA-ADDSEAKS-NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQME 339
Query: 584 YHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFL 643
+ E EK E ++ T+ K +EE+ + + +K+ +
Sbjct: 340 KEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
Query: 644 TVTVDLEQRRHLEE-QLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKT 702
V+ + + LE+ + K I++ L E K +E K L+++++E +
Sbjct: 400 NAYVETQDQLLLEKLENKRINKYLD----------EIVKEVEAKAPILKRQREEYERAQK 449
Query: 703 KKRQLEQKISSKLGSLKLMEQDTCN-------LEEEERKASTKIKEINVQKAKLVTELTN 755
L K+ + ++ +++DT LE + R+ ++K+++ Q L+ EL
Sbjct: 450 AVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
Query: 756 LIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAAS---SQLRLTEQHFIELDENRQRL 812
+ VI ++ +D ++S SQ ++ ++ EL + QRL
Sbjct: 510 ----------------ARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRL 553
Query: 813 LQKCKEL 819
L +EL
Sbjct: 554 LVALREL 560
Score = 60.1 bits (144), Expect = 1e-08
Identities = 135/666 (20%), Positives = 271/666 (40%), Gaps = 89/666 (13%)
Query: 181 QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV 240
Q++V E + + L + E K E +N E+E L + E + ++ V
Sbjct: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQV 1103
Query: 241 QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK 300
+ +Q +E ++ ++LE K W E E + +K+EV K
Sbjct: 1104 SKMASVRQHLEETTQKAES----QLLECKASWEERERM-------------LKDEVSKC- 1145
Query: 301 EGQIPVTCRIEEMENERHNLEARIKEKATD-----IKEA---------SQKCKQKQDVIE 346
CR E++E + L +I EK +D +KE S++ K ++ ++E
Sbjct: 1146 ------VCRCEDLEKQNRLLHDQI-EKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198
Query: 347 -----RKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQID 401
R++K I E + V Q E L ++R+ + +++LQ+ L N E + Q+
Sbjct: 1199 ILRFIRREKEIAETR--FEVAQVESLRYRQRVELLERELQELQDSL----NAEREKVQVT 1252
Query: 402 AITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFR 461
A T Q E+ + + E ++ E + +E+K R + + Q + K+R+
Sbjct: 1253 AKT----MAQHEELMKKTETMNVVMETNKMLREEKE------RLEQDLQQMQAKVRKLEL 1302
Query: 462 DTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDME 521
D +K E +L +D K K H+ S E ++ +
Sbjct: 1303 DILPLQEANAELSEKSGMLQAEKKLLE---EDVKRWKARNQHLVSQQKDPDTEEYRKLLS 1359
Query: 522 VFLKEVRDNKKLRVNAVIAP-KSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYL 580
KEV + ++ I K+ A S + N+ L ++ + + L
Sbjct: 1360 E--KEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL 1417
Query: 581 CCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVA 640
+ + V T ++I R + T+ +++ ++K V++TS S+
Sbjct: 1418 DAKIIDIQEKVKTITQVKKIGRRYK-TQYEELKAQQDK-VMETSAQSS-----------G 1464
Query: 641 QFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLER 700
V +++ + L+E L + K ++++S + L++T L K+ E R +++ ++
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKT---LSEKETEARNLQEQTVQL 1521
Query: 701 KTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERK----ASTKIKEINVQKAKLVTELTNL 756
+++ +L Q + + + + Q EE+ RK A +KI + K +L E L
Sbjct: 1522 QSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581
Query: 757 IKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKC 816
+ +L QK +L ++ T + K++ E +LR ++ +E + Q K
Sbjct: 1582 KQRNGALDQQKDELDVRITAL---KSQYEGRISRLERELREHQERHLEQRDEPQEPSNKV 1638
Query: 817 KELMKR 822
E ++
Sbjct: 1639 PEQQRQ 1644
Score = 58.9 bits (141), Expect = 3e-08
Identities = 147/748 (19%), Positives = 289/748 (38%), Gaps = 114/748 (15%)
Query: 262 LIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLE 321
L+E LE KR + + +E E + R +EE + ++ ++ ++E+ E L+
Sbjct: 410 LLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
Query: 322 ARIKEKATDIKEASQKCKQKQDVIERKDKHIE----ELQQAL--IVKQNEEL-------D 368
E + K ++ V+ER ++ +E +L Q + ++ + EE D
Sbjct: 470 -----------EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRD 518
Query: 369 RQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLR-----RIQDEKALCEGEIID 423
+ + E + L + N E LQ Q + LR R ++E+ +I +
Sbjct: 519 EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE 578
Query: 424 KRRERET----LEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQ 479
+ + E+ LE+ +KS + D+++ Q+ D R T + L +
Sbjct: 579 LQLKLESALTELEQLRKSRQHQMQLVDSIVRQR-DMYRILLSQTTGVAIPLHASS----- 632
Query: 480 RVCEPIMLTINMKDNKNAKYIENHIP--------SNDLRAFVFESQEDMEVFLKEVRDNK 531
+ + L K ++ + P + + +A + + QE E + KE +N+
Sbjct: 633 --LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 532 KLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPV 591
K++ N + S++ Q F S E+ D V Y +HE
Sbjct: 691 KIQ-NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ--DNVEGYRREITSLHERNQ 747
Query: 592 GTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQ 651
T ++ E++I T + + A EK V +V + N + V L Q
Sbjct: 748 KLTATTQKQEQII-NTMTQDLRGANEKLAVA------EVRAENLKKEKEMLKLSEVRLSQ 800
Query: 652 RRH--LEEQLKE--IHRKLQAVDSGLIALRET------SKHLEHKDNELRQKKKELLERK 701
+R L EQ + + LQ + G++ ET S +E ++E+ KK+L
Sbjct: 801 QRESLLAEQRGQNLLLTNLQTI-QGILERSETETKQRLSSQIEKLEHEISHLKKKLENEV 859
Query: 702 TKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICT 761
++ L + + +L K NL +TK N QK E+ L + +
Sbjct: 860 EQRHTLTRNLDVQLLDTKRQLDTETNLH-----LNTKELLKNAQK-----EIATLKQHLS 909
Query: 762 SLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMK 821
++ +Q Q T NK + D + SQLR TE+ +L E
Sbjct: 910 NMEVQVASQSSQRTGKGQPSNKEDVDDLV--SQLRQTEEQVNDLKE-------------- 953
Query: 822 RARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASC 881
L + ++YQ V ++ N + + N I+ L E A
Sbjct: 954 ------RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKN----IEVRLKES---AEF 1000
Query: 882 FTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINE 941
T L +++ +++E + ++ + +L + ++ +S V+ N ++E +++ +
Sbjct: 1001 QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQ----NEVQEALQRAST 1056
Query: 942 KFSNFFSSMQ-CAGEVDLHTENEEDYDK 968
SN + + C + + E + Y++
Sbjct: 1057 ALSNEQQARRDCQEQAKIAVEAQNKYER 1084
Score = 58.9 bits (141), Expect = 3e-08
Identities = 131/702 (18%), Positives = 278/702 (39%), Gaps = 119/702 (16%)
Query: 260 LDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHN 319
++ E +EAK + + + + Y++ K ++++ E ++E+++ + +
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNE-------------QLEKLQEQVTD 706
Query: 320 LEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKM 379
L ++ + +T + AS++ + QD +E + I L + +N++L
Sbjct: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHE-----RNQKLTA---------- 751
Query: 380 IEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVD 439
TT+ E + I+ +T DLR ++ A+ E + ++E+E L+ + +
Sbjct: 752 ---------TTQKQEQI---INTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLS 799
Query: 440 DHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIML----TINMKDNK 495
R L Q+ L T + L + + KQR+ I ++K
Sbjct: 800 QQ--RESLLAEQRGQNLLLTNLQTIQGI--LERSETETKQRLSSQIEKLEHEISHLKKKL 855
Query: 496 NAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLN 555
+ + H + +L + +++ ++ + K+L NA + +
Sbjct: 856 ENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA-------------QKEIA 902
Query: 556 ELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTA 615
LKQ+ M G +E ++ ++ + R +
Sbjct: 903 TLKQH-------------LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
Query: 616 EEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIA 675
+ K +KTS +SN V Q+ + LE+ + E+Q+ E RK ++ L
Sbjct: 950 DLKERLKTS-------TSN----VEQYQAMVTSLEESLNKEKQVTEEVRK--NIEVRLKE 996
Query: 676 LRETSKHLEHKDNELRQKKKELLERKTKK-RQLEQKISSKLGSLKLMEQDTCNLEEEERK 734
E LE K E+ ++K+EL + K + +EQ++S +L ++ + ++E ++
Sbjct: 997 SAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE---VQEALQR 1053
Query: 735 ASTKIKEIN------VQKAKLVTELTNLIKICTSLHIQKVDLIL----QNTTVISEKNKL 784
AST + ++AK+ E N + LH V+ + Q + + S + L
Sbjct: 1054 ASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHL 1113
Query: 785 ESDYMAASSQLRLTEQHFIELDENRQRLLQ--------KCKELMKRARQVCNLGAEQTLP 836
E A SQL + + E R+R+L+ +C++L K+ R + +
Sbjct: 1114 EETTQKAESQLLECKASW----EERERMLKDEVSKCVCRCEDLEKQNRLL-----HDQIE 1164
Query: 837 QEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKR 896
+ V ++ G L + + + ++I +L R E +
Sbjct: 1165 KLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224
Query: 897 EEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEK 938
+ +E L EL+ + L+ RE + QV + + +EL++K
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKV-QVTAKTMAQHEELMKK 1265
Score = 50.8 bits (120), Expect = 7e-06
Identities = 112/562 (19%), Positives = 226/562 (40%), Gaps = 83/562 (14%)
Query: 207 EMHKYHCELKNLREKEKQLE-------------TSCKEKTEYLQK-MVQRNERYKQDVER 252
E+ K + +LK L EK K+LE T KE+ E ++ +++ NER Q++E
Sbjct: 81 ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
Query: 253 FYERKRHLD---------------LIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVR 297
E + L+ ++ L+A V+Y R E E+ +L+ +
Sbjct: 141 LTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK-ELLHSQNTWLNT 199
Query: 298 KLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQ 357
+LK + E NE L+ ++ K ++ ++ + E KH+E+L
Sbjct: 200 ELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLT 259
Query: 358 ALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDE--KA 415
L + ++ + + N +L +K + ++ +A +N+L R +E K
Sbjct: 260 KLKEAKEQQASMEEKFHN------ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKL 313
Query: 416 LCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQ---RFRDTYDAVLWLRN 472
L E + K++ DH++ + +Q E ++ + R + L +
Sbjct: 314 LKEA------------GEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS 361
Query: 473 NRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKK 532
+ + E + ++ AK ++ + +L E+Q+ + L E +NK+
Sbjct: 362 ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQL---LLEKLENKR 418
Query: 533 LRVNAVIAPKSSYADKAP----SRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHE 588
+ K A KAP R E Q S +L A + ++
Sbjct: 419 INKYLDEIVKEVEA-KAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANK 477
Query: 589 VPVGTEKTRERIERVIQE------TRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQF 642
E+ R+E +++ L ++ A +V++ S+ ISS++ +
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV----- 532
Query: 643 LTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKT 702
++ L R++EE L++ +++L L+ALRE + E ++ E K L+ K
Sbjct: 533 --ISQHLVSYRNIEE-LQQQNQRL------LVALRELGETREREEQETTSSKITELQLKL 583
Query: 703 KK--RQLEQKISSKLGSLKLME 722
+ +LEQ S+ ++L++
Sbjct: 584 ESALTELEQLRKSRQHQMQLVD 605
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/312 (19%), Positives = 132/312 (42%), Gaps = 40/312 (12%)
Query: 158 QKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKN 217
+K++EE V + +L E+ KL +EK + + + E+
Sbjct: 1325 KKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKL-------LSEKEVHTKRIQQLTEEIGR 1377
Query: 218 LREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYEN 277
L+ + + S +Q + + + + + E ++ +I++ E + + +
Sbjct: 1378 LKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETI-QKDLDAKIIDIQEKVKTITQVKK 1436
Query: 278 V----RQEYEEVKLVRDRVKE-----------------EVRKLKEGQIPVTCRIEEMENE 316
+ + +YEE+K +D+V E E+++LKE + + +E++
Sbjct: 1437 IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQ 1496
Query: 317 RHNLEARIKEKATDIKEASQKCKQKQDVIER-----KDKHIEELQQALIVKQNEELDRQR 371
NL+ + EK T+ + ++ Q Q + R +D+ +E Q + + EE R+
Sbjct: 1497 VENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKA 1556
Query: 372 RIGNTRKM--IEDLQNEL-KTTENCENLQPQIDAITNDLR-RIQDEKALCEGEIIDKRRE 427
+ K+ + ++++L K E + +D ++L RI K+ EG I R E
Sbjct: 1557 IVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRI--SRLE 1614
Query: 428 RETLEKEKKSVD 439
RE E +++ ++
Sbjct: 1615 RELREHQERHLE 1626
Score = 40.8 bits (94), Expect = 0.007
Identities = 58/304 (19%), Positives = 126/304 (41%), Gaps = 10/304 (3%)
Query: 648 DLEQR-RHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTK--- 703
++E+R H +E+L R+ Q++ L L K L K+ EL + + +++
Sbjct: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
Query: 704 -KRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTS 762
K +LE + + + + + Q+ L E+ ++ + K+KE N K +L +L L S
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVS 175
Query: 763 LHIQKVDLILQNTTVISEKNKLESDYMAASSQ-LRLTEQHFIELDENRQRLLQKCKELMK 821
+ ++ L + + S+ L ++ + + L L + E+ E + L K +E+ +
Sbjct: 176 VKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR 235
Query: 822 RARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASC 881
Q+ L Q++ + T + + N L+ L +S A
Sbjct: 236 LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADD 295
Query: 882 FTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINE 941
+ E T+ EE+ +L +E + + + Q K++ + E + ++ +
Sbjct: 296 SEAKS----NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK 351
Query: 942 KFSN 945
+ N
Sbjct: 352 ELEN 355
Score = 34.7 bits (78), Expect = 0.51
Identities = 46/254 (18%), Positives = 102/254 (40%), Gaps = 25/254 (9%)
Query: 692 QKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVT 751
+ +++ E + + ++++ ++ + + + L + + + K KE+ + + + +
Sbjct: 49 ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108
Query: 752 ELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQR 811
+ + L +K DLI N + E L D + +L+ E + +
Sbjct: 109 IQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK-------ESNTTKGE 161
Query: 812 LLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDAL 871
L K EL +A V E+ L QE + +S + +L DE+ AL
Sbjct: 162 LQLKLDEL--QASDVSVKYREKRLEQEKELL--------HSQNTWLNTELKTKTDELLAL 211
Query: 872 LTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNP 931
E+ + + ++EE+ +L E++ G K + ++++ + + L
Sbjct: 212 GREKGNEIL-------ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK-LKE 263
Query: 932 LKELVEKINEKFSN 945
KE + EKF N
Sbjct: 264 AKEQQASMEEKFHN 277
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 79.7 bits (195), Expect = 1e-14
Identities = 135/729 (18%), Positives = 304/729 (41%), Gaps = 109/729 (14%)
Query: 221 KEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQ 280
KE Q++ K K Y +++E+ E ++ + D + + +E + +
Sbjct: 1461 KELQIQLELKSKEAY-----EKDEQINLLKEELDQQNKRFDCL------KGEMEDDKSKM 1509
Query: 281 EYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQ 340
E +E L + +K + ++ E + +T + E+E+ L+ ++K + KE QK +
Sbjct: 1510 EKKESNLETE-LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568
Query: 341 KQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQI 400
Q++ E KD ++E ++ ++ +N+ + + +K +E + +K+ E E L+
Sbjct: 1569 FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKE--EELKALE 1626
Query: 401 DAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRF 460
D R++ E A E+ KR+ + + KK L++Q E+K Q
Sbjct: 1627 D-------RLESESAAKLAEL--KRKAEQKIAAIKK----------QLLSQMEEKEEQYK 1667
Query: 461 RDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIP--SNDLRAFVFESQE 518
+ T + L K ++R E +L +K ++++ +P + ++ A+ + +
Sbjct: 1668 KGTESHLSELNT---KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA 1724
Query: 519 DMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMS 578
D + +++ + K + + K + + + K+ S+
Sbjct: 1725 DSQGCVQKTYEEKISVLQRNLTEKEKLLQR-----VGQEKEETVSSHFE----------- 1768
Query: 579 YLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLK 638
+ CQY + + + ++ ++ + +++ +KY + + + K N
Sbjct: 1769 -MRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN---- 1823
Query: 639 VAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEH---KDNELRQKKK 695
+++ +++LE ++ + LQ + L + K L+ + E+ + +
Sbjct: 1824 ---------NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEM 1874
Query: 696 ELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTN 755
E L K +K Q Q++ + +L+E++T EE+ S ++
Sbjct: 1875 EELTSKYEKLQALQQMDGRNKPTELLEENT-----EEKSKSHLVQP-------------- 1915
Query: 756 LIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLR-LTEQHFIELDENRQRLLQ 814
K+ +++ Q DL + EK KL + + LR L ++H EL+ ++ Q
Sbjct: 1916 --KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
Query: 815 KCKELMKRARQVCNLGAEQTLPQ---EYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDAL 871
+ +E +K+ ++ L TL Q E+ TQ+ L M ++ N E++A
Sbjct: 1974 EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ----KEQELEMTIKETINKAQEVEAE 2029
Query: 872 L----TEERSRASCFTGLNPTIVQEYTKREEEI-----EQLTEELKGKKVELDQYRENIS 922
L EE ++ ++ KR EEI E++T +++ + +L++ ++
Sbjct: 2030 LLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 2089
Query: 923 QVKERWLNP 931
Q E+ NP
Sbjct: 2090 QKLEQEENP 2098
Score = 76.6 bits (187), Expect = 1e-13
Identities = 159/785 (20%), Positives = 327/785 (41%), Gaps = 96/785 (12%)
Query: 210 KYHCELKNLREK-EKQLETSCKEKTEYLQKMVQR-NERY--KQDVERFYERKRHLDLIEM 265
+Y E++ LREK E++ ET K+K Q ++ NE+ K DV++ +L E+
Sbjct: 637 QYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 266 LEAKRPWVEYENVRQEY-----EEVKLVRDRVKEEVRK-----LKEGQIPVTCRIEEMEN 315
L+A+ E +V ++ +E++ D K ++ +KE ++ + + +++
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 316 ERHNLEARIKEKATDIKEAS-----------------QKCKQKQDVIE-----------R 347
+ + LE +KE+ +KE Q+ K DV +
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKA 816
Query: 348 KDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTE-NCENLQPQIDAITND 406
++ + +LQQ L+ + E + +++ +D+ EL + ++L Q++ ++
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
Query: 407 L-RRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYD 465
+ ++++ + E ++ D +E+E ++ ++ I++ ++ + L Q+ D
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 466 AVLWLRNNRD-KFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFL 524
++ L + KFK + E M + K + + ++ + + + +E+
Sbjct: 937 SIHILNEEYETKFKNQ--EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994
Query: 525 KEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFS--YLRELFDAPDPVMSYLCC 582
KE + N K+ + A + +D N+ +Q + + REL D L
Sbjct: 995 KEKQFNAKM-LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQ 1053
Query: 583 Q----YHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLK 638
Q IHE+ + + E+ + E + K + EK + NK I+
Sbjct: 1054 QAEELQEIHEIQL------QEKEQEVAELKQKILLFGCEKEEM------NKEITWLKEEG 1101
Query: 639 VAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKE-- 696
V Q T+ L+EQLK+ K V+S + HLE + +L + KE
Sbjct: 1102 VKQDTTL-------NELQEQLKQ---KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 697 -----LLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVT 751
L+E K + ++K+S LK +++ +L+ K++ +++ +++ KL
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 752 ELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQR 811
EL + IC +K + +L+ T +E + S A QH + ++
Sbjct: 1212 ELAIQLDIC----CKKTEALLEAKT--NELINISSSKTNAILSRISHCQH--RTTKVKEA 1263
Query: 812 LLQKCKELMKRARQVCNLGAEQ-TLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDA 870
LL K + + Q+ L EQ TL +Q + N + + D+ + + E +A
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKEN-QIKSMKADIESLVTEKEA 1322
Query: 871 LLTEERSRASCFTGLNPTIVQEYTKREEEIEQLT---EELKGKKVELDQYRENISQVKER 927
L E ++ + I Q + E I +T EELK KKVE+ + ++ + +
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 928 WLNPL 932
N +
Sbjct: 1383 LQNSI 1387
Score = 74.3 bits (181), Expect = 6e-13
Identities = 179/879 (20%), Positives = 372/879 (42%), Gaps = 173/879 (19%)
Query: 140 IDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQ-----FLPQDKVG------EFA 188
+DV K S I K QK+ E+++A ++ Q F Q KV E+
Sbjct: 467 VDVMKKSSEEQIAK---LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYL 523
Query: 189 KLSK---------IELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKM 239
K+S+ +E LE +K+I +K L++L+++ + T E L+K
Sbjct: 524 KISQEKEQQESLALEELELQKKAILTESENK----LRDLQQEAETYRTRILELESSLEKS 579
Query: 240 VQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKL 299
+Q N+ + DL LEA++ + +E+ ++ ++ K E+ L
Sbjct: 580 LQENKNQSK------------DLAVHLEAEK--------NKHNKEITVMVEKHKTELESL 619
Query: 300 KEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQAL 359
K Q + + E+ L+ ++ T++++ +KC+Q+++ + KDK I + QA
Sbjct: 620 KHQQ-------DALWTEK--LQVLKQQYQTEMEKLREKCEQEKETL-LKDKEI--IFQAH 667
Query: 360 IVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEG 419
I + NE K +E L ++K TE E+L ++ + ++++E ++ +
Sbjct: 668 IEEMNE------------KTLEKL--DVKQTE-LESLSSELSEVLKARHKLEEELSVLKD 712
Query: 420 EIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKE---DKLRQRFRDTYDAVLWLRNNRDK 476
+ ++E E E+K + H + D+++ + E + + +D + + L RDK
Sbjct: 713 QTDKMKQELEAKMDEQK--NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
Query: 477 FKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVN 536
++K+++ ++EN L A + S+ +++ + + KL V
Sbjct: 771 -------------HLKEHQ--AHVEN------LEADIKRSEGELQ------QASAKLDVF 803
Query: 537 AVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDP--VMSYLCCQYHIHEVPVGTE 594
+ KA L +L+Q +L D +++ + + V TE
Sbjct: 804 QSYQSATHEQTKAYEEQLAQLQQ--------KLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 595 KTRERIE-RVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVD---LE 650
+I+ + + + KQ E+K T Y +K+ N + + + V + L+
Sbjct: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 651 QRRHLEEQLKEIHRKLQAVDSGLIALRE----TSKHLEHKDNELRQKKKELLERKTKKRQ 706
R +++++ + +KL A + + L E K+ E K +++QK KE+ E KK+
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE-TLKKKL 974
Query: 707 LEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE--------INVQKAKLVTELTNLIK 758
L+Q+ K K +E L ++E++ + K+ E I+ ++L T I+
Sbjct: 975 LDQEAKLK----KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 759 ICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQ---K 815
T +H ++++ ++ ++ +K +++ + +++L E+ E+ E +Q++L +
Sbjct: 1031 SLTEVHRRELNDVI---SIWEKKLNQQAEELQEIHEIQLQEKE-QEVAELKQKILLFGCE 1086
Query: 816 CKELMKRARQVCNLGAEQ-TLPQEYQTQVPTIPNGHNSSLPMVFQD-------------- 860
+E+ K + G +Q T E Q Q+ + H +SL QD
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTTLNELQEQLKQ-KSAHVNSLA---QDETKLKAHLEKLEVD 1142
Query: 861 ----------LPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGK 910
L L E+ L E++ + S T T +E+ + E+ + L+ K
Sbjct: 1143 LNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDK 1202
Query: 911 KVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSS 949
+E + E ++ + + L+E + N SS
Sbjct: 1203 SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241
Score = 73.6 bits (179), Expect = 1e-12
Identities = 149/798 (18%), Positives = 339/798 (42%), Gaps = 117/798 (14%)
Query: 216 KNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVER----FYERKRHLDLIEMLEAKRP 271
K L+++ QLE KE+ ++L++ E + D++R + LD+ + ++
Sbjct: 752 KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQS--- 808
Query: 272 WVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDI 331
+E + E++ ++++++ L+ +I +T ++ E+E ++ ++ + +
Sbjct: 809 -ATHEQTKAYEEQLA----QLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV 863
Query: 332 KEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTE 391
++ Q+ +++ +E+K K + ++ ++ + N+E ++ T++++ + +N + +
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ------TKQILVEKENMI--LQ 915
Query: 392 NCENLQPQIDAITNDLRRIQDEKALCEGEIIDK-RRERETLEKEKKSVDDHIVRFDNLMN 450
E + +I+ +T L +D + E K + + + +EK K+ + +
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 451 QKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNK-NAKYIE----NHIP 505
+E KL++ +T L ++ K+ + NAK +E N
Sbjct: 976 DQEAKLKKELENT----------------------ALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 506 SNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSY 565
+D + + +Q++ L EV + +N VI+ ++ + L E+ +
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVH---RRELNDVISIWEKKLNQ-QAEELQEIHEIQLQEK 1069
Query: 566 LRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF 625
+E+ + ++ + C + + E T + E V Q+T L ++ ++ + + S
Sbjct: 1070 EQEVAELKQKILLFGC-----EKEEMNKEITWLKEEGVKQDTTLNEL----QEQLKQKSA 1120
Query: 626 YSNKVISSNTSLKVAQFLTVTVD----LEQRRHLEEQLKEIHRKLQAVDSGLIALRETSK 681
+ N + T LK A + VD L++ L+EQL E+ + L D ++ E +
Sbjct: 1121 HVNSLAQDETKLK-AHLEKLEVDLNKSLKENTFLQEQLVEL-KMLAEEDKRKVS--ELTS 1176
Query: 682 HLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
L+ D E Q K E+ K + + KL ++ D C + E + +
Sbjct: 1177 KLKTTDEEF-QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 742 INVQKAKLVTELTN---------------LIKICTSLHIQKVDLILQNTTVISEKNKLES 786
IN+ +K L+ LIK CT + +++ L+ T E+N L
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCT---VSELEAQLRQLT--EEQNTLNI 1290
Query: 787 DYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTI 846
+ A+ QL E + + + L+ + + L K +E+ + TQ+
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK---ESCITQLKKE 1347
Query: 847 PNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEE--IEQLT 904
+ + +++ ++ ++L EI +L + T LN + + E+E I L
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQ-------LTDLNVQLQNSISLSEKEAAISSLR 1400
Query: 905 EELKGKKVE-LDQY-----------RENISQVK--ERWLNPLKELVEKINEKFSNFFSSM 950
++ +K E LDQ +E IS ++ + W N E +K +F+ +++
Sbjct: 1401 KQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460
Query: 951 QCAGEVDLHTENEEDYDK 968
+ ++ L +++E Y+K
Sbjct: 1461 K-ELQIQLELKSKEAYEK 1477
Score = 70.1 bits (170), Expect = 1e-11
Identities = 169/855 (19%), Positives = 337/855 (39%), Gaps = 135/855 (15%)
Query: 153 KKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPE-MHKY 211
K+ TT ++E++ + V +L Q D+ A L K+E+ KS+ + +
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQ----DETKLKAHLEKLEV--DLNKSLKENTFLQEQ 1156
Query: 212 HCELKNLREKEK----QLETSCKEKTEYLQKMVQRNERYKQDVE-RFYERKR-------H 259
ELK L E++K +L + K E Q + +E+ + +E + E K+
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216
Query: 260 LDLI-----EMLEAKRPWVEYENVRQEYEEVKLVR-DRVKEEVRKLKEGQIPVTCRIEEM 313
LD+ +LEAK E N+ L R + K+KE + TC + E+
Sbjct: 1217 LDICCKKTEALLEAKTN--ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 314 ENERHNL---------------------EARIKEKATDI------KEASQK--------C 338
E + L E +IK DI KEA QK
Sbjct: 1275 EAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAA 1334
Query: 339 KQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQP 398
+K+ I + K + E A+ + + E +++ I + K + DL +L +N +L
Sbjct: 1335 SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL---QNSISLSE 1391
Query: 399 QIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQ 458
+ AI++ ++ +EK ++ D + +TL KEK S + + + N ++ + K +
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQS 1451
Query: 459 RFRDTYDAVLWLR---NNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFE 515
RF + V L+ + K E I L D +N ++ + L+ + +
Sbjct: 1452 RFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF-------DCLKGEMED 1504
Query: 516 SQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKA-PSRSLNE-LKQYGFFSYLRELFDAP 573
+ ME + K + ++ + K SLNE LK Y +
Sbjct: 1505 DKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY----------NQQ 1554
Query: 574 DPVMSYLCCQYHIHEVPVGTEK---TRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKV 630
+ Q H +G EK +E E+++ T Q+Y+ + + K +
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVN 1612
Query: 631 ISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRE---------TSK 681
+S + + + L ++ E L E ++ +K+ A+ L++ E T
Sbjct: 1613 LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672
Query: 682 HLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
HL + +L+++++E+ + K + +E S L + + E+EE + +++
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
Query: 742 INVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH 801
+K ++ ++ + + +LQ E+ M Q RL +
Sbjct: 1733 TYEEKISVLQR-----------NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLE 1781
Query: 802 FIELDENR-QRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNS-----SLP 855
E ++ Q ++ +E ++ + +L Q + +E G N+ +L
Sbjct: 1782 HAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKE---------GGKNNIQAKQNLE 1832
Query: 856 MVFQDLPNTLD--EIDALLTEERSRA--SCFT---GLNPTIVQEYTKREEEIEQLTEELK 908
VF D+ TL E+ + E++ + SC ++ ++E T + E+++ L +++
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL-QQMD 1891
Query: 909 GKKVELDQYRENISQ 923
G+ + EN +
Sbjct: 1892 GRNKPTELLEENTEE 1906
Score = 69.7 bits (169), Expect = 1e-11
Identities = 172/907 (18%), Positives = 361/907 (39%), Gaps = 108/907 (11%)
Query: 135 VITREIDVAKNQSFWFINKKSTTQ-KIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKI 193
++T+++ AK S +N++ T+ K E+K+ + + + + L + + + AKL K
Sbjct: 926 ILTQKLS-AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK- 983
Query: 194 EL------LEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYK 247
EL L EK + + + +LET+ KE+ E L ++ + R
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV---HRREL 1040
Query: 248 QDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVT 307
DV +E+K + E+ QE E++L ++EV +LK+ +
Sbjct: 1041 NDVISIWEKKLNQQAEEL--------------QEIHEIQL--QEKEQEVAELKQKILLFG 1084
Query: 308 CRIEEMENERHNLEARIKEKATDIKEASQKCKQK--------QDVIERKDKHIEELQQAL 359
C EEM E L+ ++ T + E ++ KQK QD + K H+E+L+ L
Sbjct: 1085 CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK-AHLEKLEVDL 1143
Query: 360 --IVKQNEELDRQ-----RRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQD 412
+K+N L Q ++ + +L ++LKTT+ + + ++
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDE-------------EFQSLKS 1190
Query: 413 EKALCEGEIIDKRRERETLEKEKK-SVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLR 471
+ DK E + L +E +D + + L+ K ++L +A+L
Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRI 1250
Query: 472 NNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNK 531
++ +V E +++ A+ + N L ++ +E +++ +
Sbjct: 1251 SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK-SM 1309
Query: 532 KLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPV 591
K + +++ K + + ++ ++ + L++ + + + + + + E V
Sbjct: 1310 KADIESLVTEKEALQKEGGNQQQAASEKESCITQLKK--ELSENINAVTLMKEELKEKKV 1367
Query: 592 GTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVD--- 648
+++ + +L+ + EK +S L Q L+ VD
Sbjct: 1368 EISSLSKQLTDL--NVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425
Query: 649 ------LEQRRHLEEQLKEIHRKLQA-VDSGLIALRETSKHLEHKDNELRQKKKELLERK 701
LEQ + E +K Q+ ++E LE K E +K +++ K
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLK 1485
Query: 702 TKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICT 761
+ Q ++ G ME D +E++E T++K + +L +T
Sbjct: 1486 EELDQQNKRFDCLKGE---MEDDKSKMEKKESNLETELKSQTARIMELEDHITQ-----K 1537
Query: 762 SLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKE-LM 820
++ I+ ++ +L+N +++ +E +L QHF EL E + +++ +E ++
Sbjct: 1538 TIEIESLNEVLKN---YNQQKDIEH------KELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 821 KRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRAS 880
QV ++ AE ++ V L + L + E A L E + +A
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES---ESAAKLAELKRKAE 1645
Query: 881 C-FTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKI 939
+ ++ + ++EE+ + KG + L + + Q +ER ++ L+E ++ +
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYK------KGTESHLSELNTKL-QEREREVHILEEKLKSV 1698
Query: 940 NEKFSNFFSSMQCAGEVDLHTENEEDYDK------YGIRIRVKFRSSTQLHELTPHHQSG 993
S + A V +TE EE + Y +I V R+ T+ +L
Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758
Query: 994 GERSVST 1000
E +VS+
Sbjct: 1759 KEETVSS 1765
Score = 56.6 bits (135), Expect = 1e-07
Identities = 145/803 (18%), Positives = 313/803 (38%), Gaps = 104/803 (12%)
Query: 237 QKMVQRNERYKQDVERFYERKRHLDLI---EMLEAKRPWVEYENVRQEYEEVKLVR-DRV 292
++++QR R ++ + + R ++ +L+ +ML+ ++ + + + + ++ L R +
Sbjct: 137 EQLIQRLRRMERSLSSY--RGKYSELVTAYQMLQREKK--KLQGILSQSQDKSLRRIAEL 192
Query: 293 KEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHI 352
+EE++ ++ + + + E+ + ++ + + +K+ + DV++ + +
Sbjct: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQ-L 251
Query: 353 EELQQALIVKQNEELDRQRRI--GNTRKMIEDLQNELKTTENC----------------- 393
E + ++N E D + + G + K +E LQ +K EN
Sbjct: 252 EPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL 311
Query: 394 -----ENLQPQIDAITNDLRRIQD----EKALCEGEIIDKRRERETLEKEKKSVDDHIVR 444
E LQ Q+D +L +I+D EK ++ D + E LE++K V R
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
Query: 445 -FDNLMNQKED---KLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYI 500
+ KE+ +LR R + LR ++K ++ E + ++
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 501 ENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQY 560
+ ++ + ++ E+ + L++ K V V+ KSS A + L+E
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM-KKSSEEQIAKLQKLHE---- 486
Query: 561 GFFSYLRELFDAPDPVMSYLCCQYH--IHEVPVGTEKTRERIERVIQETRLKQIYTAEEK 618
+EL + L + ++ V EK++ ++ QE ++ EE
Sbjct: 487 ------KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
Query: 619 YVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRE 678
+ K + + + A+ + LE LE+ L+E K Q+ D + E
Sbjct: 541 ELQKKAILTESENKLRDLQQEAETYRTRI-LELESSLEKSLQE--NKNQSKDLAVHLEAE 597
Query: 679 TSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCN--LEEEERKAS 736
+KH + + + K EL ++ K Q + + KL LK Q E+ E++
Sbjct: 598 KNKHNKEITVMVEKHKTEL---ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654
Query: 737 TKIKEINVQKAKLVTELTNLIKICTSLHIQKVD---LILQNTTVISEKNKLESDYMAASS 793
T +K+ + + E+ K L +++ + L + + V+ ++KLE +
Sbjct: 655 TLLKDKEIIFQAHIEEMNE--KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712
Query: 794 QLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSS 853
Q D+ +Q L K E +Q QV +I H S
Sbjct: 713 Q----------TDKMKQELEAKMDE----------------QKNHHQQQVDSIIKEHEVS 746
Query: 854 LPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEEL------ 907
+ + L + +++++ LL E + + + E E++Q + +L
Sbjct: 747 IQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSY 806
Query: 908 -KGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEED- 965
+ Y E ++Q++++ L+ E + + E+D H +D
Sbjct: 807 QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866
Query: 966 ---YDKYGIRIRVKFRSSTQLHE 985
+K + K +S TQ++E
Sbjct: 867 MQQLEKQNSEMEQKVKSLTQVYE 889
Score = 50.8 bits (120), Expect = 7e-06
Identities = 75/424 (17%), Positives = 185/424 (43%), Gaps = 50/424 (11%)
Query: 594 EKTRERIERVIQET-RLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQR 652
E +E+++ +QE ++K ++ AE+ ++ T L+ A+ L ++ ++
Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLI-------------TQLRDAKNLIEQLEQDKG 363
Query: 653 RHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKIS 712
+ E +++H L+ + + LR K + + ELR++K++ + +LE+ +S
Sbjct: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK--SERAAFEELEKALS 421
Query: 713 SKLGSLKLMEQDTCNLEEE----ERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKV 768
+ + + + ++E+ E+ + + + + +++ E+ +++K + I K+
Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481
Query: 769 DLILQNTTVISEK---NKLESDYMAASSQLRL----TEQHFIELD---ENRQRLLQKCKE 818
+ + E+ KL++ Q+++ ++ ++++ E ++ L + E
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541
Query: 819 LMKRARQVCNLGAEQTLPQE---YQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEE 875
L K+A + + L QE Y+T++ + SSL Q+ N ++ L E
Sbjct: 542 LQKKAILTESENKLRDLQQEAETYRTRILEL----ESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 876 RSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKEL 935
+++ N I K + E+E L K + + E + +K+++ +++L
Sbjct: 598 KNKH------NKEITVMVEKHKTELESL------KHQQDALWTEKLQVLKQQYQTEMEKL 645
Query: 936 VEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHE-LTPHHQSGG 994
EK ++ + + + NE+ +K ++ S++L E L H+
Sbjct: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705
Query: 995 ERSV 998
E SV
Sbjct: 706 ELSV 709
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 78.6 bits (192), Expect = 3e-14
Identities = 60/277 (21%), Positives = 148/277 (53%), Gaps = 33/277 (11%)
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML 266
E K E K LRE+E+Q++ ++ E +KM ++ E+ + ER +E+++ + E
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 267 ---EAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEME------NER 317
+ +R W + E +R++ E ++ ++++ E+V K++E + +++E E E+
Sbjct: 392 MRDQEERMWEQDERLREKEERMR-EQEKMWEQVEKMREEK-----KMQEQEKKTRDQEEK 445
Query: 318 HNLEARIKEKATDIKEASQKCKQKQDVIERKDKHI-----EELQQALIVKQNEELDRQRR 372
E RI+E+ ++E + +++++ ++++++++ +E QQ + +Q E+L Q +
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 373 IGNTRKMIEDLQNELKTTENC----------ENLQPQIDAITNDLRRIQDEKALCEGEII 422
+ + I + + +++ E E ++ Q D + +++D++ +
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ-- 563
Query: 423 DKRRERETLEKEKKSVD-DHIVRFDNLMNQKEDKLRQ 458
++R E++T E+EKK+ D + +R + M ++E K+R+
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600
Score = 64.3 bits (155), Expect = 6e-10
Identities = 83/536 (15%), Positives = 246/536 (45%), Gaps = 33/536 (6%)
Query: 216 KNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHL--DLIEMLEAKRPWV 273
+ LRE+EK++ ++ +++ ++ + ++ E+ + +++ L E+ E ++
Sbjct: 279 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338
Query: 274 EYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPV---TCRIEEMENERHNLEARIKEKATD 330
E + +R++ E+++ +++ E+ K++E + + R+ E E + E +++++
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
Query: 331 IKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTT 390
+ E ++ ++K++ + ++K E+++ K EE Q + TR E +Q E +
Sbjct: 399 MWEQDERLREKEERMREQEKMWEQVE-----KMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Query: 391 ENCENLQPQIDAITNDLRRIQ-DEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLM 449
E + ++ + + + ++Q E+ + E E + +++R +KEK + + + +
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 450 NQKEDKLR-QRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIEN---HIP 505
++E+K+R Q + +W ++K +++ + M+D + + +
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMW---RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKK 570
Query: 506 SNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSY 565
+ + ++ +E M + KK+R + + + + E ++ +
Sbjct: 571 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE-QEEKMWEQ 629
Query: 566 LRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF 625
++ + + + + E ++ E+ E++ + ++++ +E+ +
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ---EEKI 686
Query: 626 YSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEH 685
+ + + T + + T D E+ R EE ++E +K++ + +RE + ++
Sbjct: 687 WEQEKMEKKTQEQEKK----TWDQEKMRE-EESMREREKKMREEEE---MMREQEEKMQE 738
Query: 686 KDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
++ +++++++E+ E++ K + E+K+ + +L EQ E E+ + KI E
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQ---QRLPEQKEKLWEHEKMQEQEKIWE 791
Score = 63.5 bits (153), Expect = 1e-09
Identities = 91/539 (16%), Positives = 239/539 (44%), Gaps = 81/539 (15%)
Query: 230 KEKTEYLQKMVQRNERYKQDVE-RFYERKRHLDLIEMLEAK--------RPWVEYENVRQ 280
K+K LQ+ + E K +++ E KR L+ + L + W + E +R+
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283
Query: 281 EYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQ 340
+ ++++ +++ + +L+E + ++ E E + E R++E+ +++E ++ ++
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQE----GKMREQEEKMWRQEKRLREQEKELREQEKELRE 339
Query: 341 KQDVIERKDKHIEE-----LQQALIVKQNEELDRQ-RRIGNTRKMIEDLQNELKTTENCE 394
++++ E++++ E+ Q+ + +Q E++ RQ R+ K + + + +++ E E
Sbjct: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE--E 397
Query: 395 NLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKED 454
+ Q + + R+++++ + E ++K RE + +++++K D + Q+E+
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQ--VEKMREEKKMQEQEKKTRDQEEKM-----QEEE 450
Query: 455 KLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVF 514
++R+R + + +R +K +++ NM + + ++ + +P + +
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQ-------EENMWEQEEKEWQQQRLPEQKEKLWEQ 503
Query: 515 ESQEDMEVFL----KEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELF 570
E ++ E + +++RD +++ + K+ +RE
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEM--------------------WGQEKKMWRQEKMREQE 543
Query: 571 DAPDPVMSYLCCQYHIHEVPVGTEKTRERIERV-IQETRLKQIYTAEEKYVVKTSFYSNK 629
D ++ EK R++ +++ QE R+++ +EK KT K
Sbjct: 544 D----------------QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK---KTWDQEEK 584
Query: 630 VISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNE 689
+ + + + + E R EE+++E K+Q + + E + E K E
Sbjct: 585 MREEERMREREK--KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 690 LRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAK 748
+K E E+ ++++L ++ K+ EQ+ +EE+ K+++ ++ K
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701
Score = 59.3 bits (142), Expect = 2e-08
Identities = 63/342 (18%), Positives = 154/342 (45%), Gaps = 36/342 (10%)
Query: 214 ELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML------- 266
E + +RE+EK++ + E +KM ++ E + E+ ++++R + E L
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 267 -EAKRPWVEYENVRQEYE----EVKLVR-DRVKEEVRKLKEGQIPVTCRIEEMENERHNL 320
+ ++ W + E +R + E E K+ R ++++E+ ++ E + + + ++M ++ +
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
Query: 321 EARIKEKATDIKEASQKCKQKQDVIERKDK--HIEELQQALIVKQNEELDRQRRIGNTRK 378
E + +E+ + +K ++++ + ER+ K EE+ + K E+ ++ + K
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE--QEEK 625
Query: 379 MIED----LQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEII------------ 422
M E + E K E E + Q + + R + ++ L E E +
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 423 ---DKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQ 479
++ E++T E+EKK+ D +R + M ++E K+R+ + ++ +K ++
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQE 745
Query: 480 RVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDME 521
+ E M + + + + +P + + E ++ E
Sbjct: 746 QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 787
Score = 54.7 bits (130), Expect = 5e-07
Identities = 56/293 (19%), Positives = 149/293 (50%), Gaps = 22/293 (7%)
Query: 181 QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV 240
++K+ E ++ + E E+ + + K + + ++E+E+++ ++ E +KM
Sbjct: 582 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641
Query: 241 QRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRV--KEEVRK 298
++ E+ + E+ +E++R + E K E+E + QE E+++ +++ +E++ K
Sbjct: 642 EQEEKMWEQEEKMWEQQR------LPEQKEKLWEHEKM-QEQEKMQEQEEKIWEQEKMEK 694
Query: 299 LKEGQIPVTCRIEEMENER--HNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQ 356
+ Q T E+M E E +++E+ ++E +K +++++ ++ +++ + E Q
Sbjct: 695 KTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE-Q 753
Query: 357 QALIVKQNEELDRQRRIGNTRKMI---EDLQNELKTTENCENLQPQIDAI--TNDLRRIQ 411
+ + +Q E++ Q+R+ ++ + E +Q + K E E ++ Q + + + R Q
Sbjct: 754 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ 813
Query: 412 DEKALCEGEIIDKRRERETLEKEKKSVDDHIV-----RFDNLMNQKEDKLRQR 459
+EK + E + + E+ ++EK + + + + M +E+K+R++
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866
Score = 40.4 bits (93), Expect = 0.009
Identities = 67/348 (19%), Positives = 143/348 (41%), Gaps = 63/348 (18%)
Query: 616 EEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQL--KEIHRKLQA----- 668
+E+ + Y N + + K A+ L + L + E QL KE+ RKL+
Sbjct: 204 KERDALSLELYRNTITNEELKKKNAE-LQEKLPLAESEKSEIQLNVKELKRKLERAKFLL 262
Query: 669 --VDSGLIA---------LRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGS 717
V + + LRE K + ++ ++ ++++ L E++ K R+ E+K+ +
Sbjct: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKR 322
Query: 718 LKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTV 777
L+ E++ E+E R+ KE+ Q+ ++ + + + + Q+ + Q +
Sbjct: 323 LREQEKELREQEKELREQ----KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378
Query: 778 ISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQ 837
++ ++ ++R E+ E DE + ++ +E K QV + E+ + +
Sbjct: 379 WEQEKQMREQ----EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
Query: 838 EYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKRE 897
+ + T D+ + + EER R +E RE
Sbjct: 435 QEK----------------------KTRDQEEKMQEEERIRE-----------REKKMRE 461
Query: 898 EEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELV---EKINEK 942
EE +E K +K E + + + + +++ L KE + EK+ E+
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Score = 39.7 bits (91), Expect = 0.016
Identities = 40/192 (20%), Positives = 94/192 (48%), Gaps = 7/192 (3%)
Query: 181 QDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV 240
+ K + K+ + E + EK + E E K ++E+E++++ +E E +KM
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEK-MQEQEEKMQEQEEEMWEQEEKMW 758
Query: 241 QRNERYKQDVERFYERKRHL-DLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKL 299
++ E+ + +R E+K L + +M E ++ W + E +R + E+++ ++++ + K+
Sbjct: 759 EQEEKMWEQ-QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM 817
Query: 300 KEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQAL 359
+ + + + E+M + + + +EK +E K ++K E K + EE +
Sbjct: 818 RGQEEKMWGQEEKMWGQEEKMWGQ-EEKMWGQEE---KMEEKMQGQEEKMREQEEKMRGQ 873
Query: 360 IVKQNEELDRQR 371
K E+ ++ R
Sbjct: 874 EEKMREQEEKMR 885
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 77.8 bits (190), Expect = 5e-14
Identities = 160/810 (19%), Positives = 330/810 (40%), Gaps = 109/810 (13%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K EL LR+ +L EKT L Q+ E K++ E+ + + +++ EA+
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKL----QQEEVQKKNAEQAATQLK----VQLQEAE 494
Query: 270 RPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKAT 329
R W E V+ +++ + + Q + + ENE +L +++ +
Sbjct: 495 RRWEE-------------VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 330 DIKEASQKCKQKQDVIERKDKHIEELQQAL--IVKQNEELDRQRRIGNTR---------- 377
++ Q+ Q + +++ E LQ + I++QNE L Q + +++
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 378 -----KMIEDLQNELKTTENCENLQPQIDAITN---DLRRIQDEKALCEGEIIDKRRERE 429
K+I + ++K TE ++L + D +T+ +L+ IQ+ L + E+ ++ +
Sbjct: 602 AEELHKVIAEKDKQIKQTE--DSLASERDRLTSKEEELKDIQNMNFLLKAEV----QKLQ 655
Query: 430 TLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAV------LWLRNNRDKFKQRVCE 483
L E+ + + + + K+DK+R + + N+++K + +
Sbjct: 656 ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
Query: 484 PIMLTINMKDNKN-AKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPK 542
+ ++ + NK+ + +E I D + E E +E L +V K+ +NA+
Sbjct: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE--ELLETGLIQVA-TKEEELNAIRTEN 772
Query: 543 SSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIER 602
SS + + Q F S + EL + IHE + E +E
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEEL-------------KKVIHEKDGKIKSVEELLEA 819
Query: 603 VIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHL----EEQ 658
+ + K+ + K +K + K N L+ AQ L++T +++ ++L EEQ
Sbjct: 820 ELLKVANKEKTVQDLKQEIK----ALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
Query: 659 LKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK-------RQLEQKI 711
+ + L+ + L + + L+ ++ L+ +E+ + K+ +LE +
Sbjct: 876 MNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVL 935
Query: 712 SSKLGSLKLMEQDTCNLEEEERKASTKIKEI-NVQ-KAKLVTELTNLIKICTSLHIQKVD 769
K LK +E L+E E S+K + + +VQ + KL +K
Sbjct: 936 KEKENELKRLE---AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
Query: 770 LILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNL 829
+ VISE+ K S L+ +H + + + + + E + ++
Sbjct: 993 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD 1052
Query: 830 GAEQTLPQEYQTQVPTIPNGHNSSLPMVFQ--DLPNTLDEIDALLTEERSRASCFTGLNP 887
+T +E Q QV + L +F +P+ L + L E+ C G +
Sbjct: 1053 KVNKT-SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1111
Query: 888 T----IVQEYTKREEEIEQL----TEELKGKKVE----LDQYRENISQVKERWLNPLKEL 935
+ +++ K +E+ L E+ K E L + + ++ Q + +W + E
Sbjct: 1112 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1171
Query: 936 VEKINEKFSNFFSSMQCAGEVD-LHTENEE 964
+ I + S+F SS Q E++ L +EN++
Sbjct: 1172 HKTIKQMQSSFTSSEQ---ELERLRSENKD 1198
Score = 73.9 bits (180), Expect = 8e-13
Identities = 159/785 (20%), Positives = 318/785 (40%), Gaps = 127/785 (16%)
Query: 194 ELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERF 253
++ T S+ E+HK + EK+KQ++ + ++ + E K
Sbjct: 591 QIAAQTSASVLAEELHKV------IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMN 644
Query: 254 YERKRHLDLIEMLEAKRPWVEYE------NVRQEYEEVKLVRDRVKEEV-RKLKEGQIPV 306
+ K + ++ L ++ +E +V + ++++L+ ++++ E+ K++E +I +
Sbjct: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI-L 703
Query: 307 TCRIEEMENERHNLEARIKEKAT-DIKEASQKCKQKQDVIERKDKHIEEL---------- 355
+ + +++E L+ + E+ D+ E +KC Q++D K K +EEL
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD---EKLKTVEELLETGLIQVAT 760
Query: 356 ------------------QQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQ 397
Q L KQN+++ + +K+I + ++K+ E E L+
Sbjct: 761 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE--ELLE 818
Query: 398 PQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEK-EKKSVDDHIVRFDNLMNQKEDK- 455
++ + N + +QD K E + + + LEK ++ S+ + NL+ KE++
Sbjct: 819 AELLKVANKEKTVQDLKQ--EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
Query: 456 ------LRQRFRDTYDAVLWLRN---NRDKFKQRVCEPIMLTINMKDNKNAKYIEN---- 502
L ++ +D + WL++ + K V E + N+K+ +A E
Sbjct: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE--VAQHNLKEASSASQFEELEIV 934
Query: 503 -HIPSNDLR---AFVFESQEDME---VFLKEVRDNKKLRVNAVIAPKSSYADKAPS---- 551
N+L+ A + E + D+ L++V+D KL + + K +A S
Sbjct: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
Query: 552 ------RSLNELKQYGFFSYLRELFDAPDPVM----SYLCCQYHIHEVPVGTEKTRERIE 601
S E + G ++ L L DA + + E TEK +
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054
Query: 602 RVIQETRLKQIYTAE-EKYVVKTSFYSNKVISSNTSL---------KVAQFLTVTVDLEQ 651
+ R +Q+ E E V + + SN S K + + T E+
Sbjct: 1055 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1114
Query: 652 RRHLEEQLK---EIHRKLQ----------AVDSGLIALRETSKHLEHKDNELRQKKKELL 698
+ LE +LK E+H LQ A G+ L++ + +E ++N+ + K E
Sbjct: 1115 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI--LQKLQRSVEQEENKWKVKVDE-- 1170
Query: 699 ERKTKKRQLEQKISS--KLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNL 756
KT K+ SS +L L+ +D NL E ++++ ++++ VTE+ L
Sbjct: 1171 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1230
Query: 757 IKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH-----FIELDENRQR 811
+ T L + D + E N L++ ++LR TEQ+ +L + +Q
Sbjct: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR-TEQNERQKVAGDLHKAQQS 1289
Query: 812 LLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDAL 871
L +++K A + P+ ++ T+ + SL L L ++
Sbjct: 1290 LELIQSKIVKAAGDTTVIENSDVSPETESSEKETM----SVSLNQTVTQLQQLLQAVNQQ 1345
Query: 872 LTEER 876
LT+E+
Sbjct: 1346 LTKEK 1350
Score = 53.9 bits (128), Expect = 8e-07
Identities = 128/648 (19%), Positives = 256/648 (39%), Gaps = 101/648 (15%)
Query: 133 NLVITREIDVAK---NQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAK 189
N +T+E+ K N F + +K++ EK K+ +
Sbjct: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK----------------DGKIKSVEE 815
Query: 190 LSKIELLEATEKSIGPPEMHKYHCELKNLREK------EKQLETSCKEKTEYLQKMVQRN 243
L + ELL+ K ++ + E+K L+E+ EK + S K + LQ +++
Sbjct: 816 LLEAELLKVANKEKTVQDLKQ---EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK 872
Query: 244 ERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVK-----LVRDRVKEEVRK 298
E ++ E K + L W++ ++++E E +K + + +KE
Sbjct: 873 EEQMNTMKAVLEEKE-----KDLANTGKWLQ--DLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 299 LKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEEL--- 355
+ ++ + ++E ENE LEA +KE+ +D+ +Q + QD + IE+L
Sbjct: 926 SQFEELEIV--LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 356 --QQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDE 413
QQA +EEL + I K I L NEL + ++ Q + + NDLR E
Sbjct: 984 NYQQASSFPPHEEL--LKVISEREKEISGLWNELDSLKDAVEHQRKKN---NDLREKNWE 1038
Query: 414 --KALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLR 471
+AL E + + + +T ++ ++ V+ + ++ + K+ +Y WL
Sbjct: 1039 AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE--WLH 1096
Query: 472 NNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQ-EDMEVFLKEVRDN 530
K K+ + ++ K +E+ + D + + + E + L E
Sbjct: 1097 GFEKKAKECMA-------GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI 1149
Query: 531 KKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVP 590
+ +V ++ + K S +KQ ++ F + + + L + E
Sbjct: 1150 LQKLQRSVEQEENKWKVKV-DESHKTIKQ------MQSSFTSSEQELERLRSENKDIE-- 1200
Query: 591 VGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLE 650
+ RE +E + EK ++ S Y +V ++ LT E
Sbjct: 1201 -NLRREREHLEMEL------------EKAEMERSTYVTEV------RELKDLLT-----E 1236
Query: 651 QRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQK 710
++ L++ E R+ + ++ L ET L + NE ++ +L + + ++ K
Sbjct: 1237 LQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1296
Query: 711 ISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIK 758
I G ++E + E E + T +N + VT+L L++
Sbjct: 1297 IVKAAGDTTVIENSDVSPETESSEKETMSVSLN----QTVTQLQQLLQ 1340
Score = 41.2 bits (95), Expect = 0.005
Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 24/269 (8%)
Query: 661 EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK-RQLEQKISSKLGSLK 719
+IH Q + ++ + +E + L+Q+ L + + QLE K S++L L+
Sbjct: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR 452
Query: 720 LMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVIS 779
QD L E + + K+++ VQK N + T L +Q + + V S
Sbjct: 453 ---QDYARLVNELTEKTGKLQQEEVQK-------KNAEQAATQLKVQLQEAERRWEEVQS 502
Query: 780 EKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEY 839
K +++ AA L + F+ + Q L K + + +Q+ EQ L Q
Sbjct: 503 YIRKRTAEHEAAQQDL---QSKFVAKENEVQSLHSKLTDTLVSKQQL-----EQRLMQLM 554
Query: 840 QTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTG---LNPTIVQEYTKR 896
+++ + SL M QD+ + + A + + S+ + T L + + ++
Sbjct: 555 ESEQKRV--NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK 612
Query: 897 EEEIEQLTEELKGKKVELDQYRENISQVK 925
+++I+Q + L ++ L E + ++
Sbjct: 613 DKQIKQTEDSLASERDRLTSKEEELKDIQ 641
Score = 40.8 bits (94), Expect = 0.007
Identities = 134/670 (20%), Positives = 267/670 (39%), Gaps = 121/670 (18%)
Query: 386 ELKTTENCENLQPQIDAITNDLRRIQ--DEKALCEGEIIDKRRERETLEKE--KKSVDDH 441
+LKT + EN + + L+ + +++ALC ++D +E+ + ++ KKS
Sbjct: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALC---VVDLLKEKSGVIQDALKKSSKGE 326
Query: 442 IVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPI-------MLTINMKDN 494
+ + + +K DKL ++ A +D+ KQ E + ++ MKD
Sbjct: 327 LTTLIHQLQEK-DKLLAAVKEDAAAT------KDRCKQLTQEMMTEKERSNVVITRMKDR 379
Query: 495 KNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSL 554
E+++ N + E+Q+ M++ ++VR+ + + A + ++ A S +
Sbjct: 380 IGTLEKEHNVFQNKIHVSYQETQQ-MQMKFQQVREQMEAEI-AHLKQENGILRDAVSNTT 437
Query: 555 NEL--KQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
N+L KQ + LR Q + V TEKT + + +Q+ +Q
Sbjct: 438 NQLESKQSAELNKLR---------------QDYARLVNELTEKTGKLQQEEVQKKNAEQ- 481
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
+ T LKV QL+E R+ + V S
Sbjct: 482 --------------------AATQLKV------------------QLQEAERRWEEVQSY 503
Query: 673 LIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEE 732
+ + T++H E +L+ K + ++ + + L K++ L S + +EQ L E E
Sbjct: 504 I--RKRTAEH-EAAQQDLQSK---FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557
Query: 733 RKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVD------LILQNTTVISEKNK--L 784
+K K + + +Q ++ + L H Q L + VI+EK+K
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
Query: 785 ESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVP 844
+++ AS + RLT + D L K + +++ + + N A E Q
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALANEQAAAAHELEKMQQSV 675
Query: 845 TIPNGHNSSLPMVFQ-DLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKRE--EEIE 901
+ + L Q ++ N ++E L + ++ S L T+V E ++ E++E
Sbjct: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ-TLVSEQPNKDVVEQME 734
Query: 902 QLTEELKGKKVELDQYRE-NISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT 960
+ +E K +++ E + QV + +E + I + S+ +Q DL
Sbjct: 735 KCIQEKDEKLKTVEELLETGLIQVATK-----EEELNAIRTENSSLTKEVQ-----DLKA 784
Query: 961 ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE 1020
+ + +V F S + + H + G +SV +L L+ N+ + V +
Sbjct: 785 KQND---------QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK--EKTVQD 833
Query: 1021 INQGMDPINE 1030
+ Q + + E
Sbjct: 834 LKQEIKALKE 843
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 77.8 bits (190), Expect = 5e-14
Identities = 160/810 (19%), Positives = 330/810 (40%), Gaps = 109/810 (13%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K EL LR+ +L EKT L Q+ E K++ E+ + + +++ EA+
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKL----QQEEVQKKNAEQAATQLK----VQLQEAE 494
Query: 270 RPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKAT 329
R W E V+ +++ + + Q + + ENE +L +++ +
Sbjct: 495 RRWEE-------------VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 330 DIKEASQKCKQKQDVIERKDKHIEELQQAL--IVKQNEELDRQRRIGNTR---------- 377
++ Q+ Q + +++ E LQ + I++QNE L Q + +++
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 378 -----KMIEDLQNELKTTENCENLQPQIDAITN---DLRRIQDEKALCEGEIIDKRRERE 429
K+I + ++K TE ++L + D +T+ +L+ IQ+ L + E+ ++ +
Sbjct: 602 AEELHKVIAEKDKQIKQTE--DSLASERDRLTSKEEELKDIQNMNFLLKAEV----QKLQ 655
Query: 430 TLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAV------LWLRNNRDKFKQRVCE 483
L E+ + + + + K+DK+R + + N+++K + +
Sbjct: 656 ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
Query: 484 PIMLTINMKDNKN-AKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPK 542
+ ++ + NK+ + +E I D + E E +E L +V K+ +NA+
Sbjct: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE--ELLETGLIQVA-TKEEELNAIRTEN 772
Query: 543 SSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIER 602
SS + + Q F S + EL + IHE + E +E
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEEL-------------KKVIHEKDGKIKSVEELLEA 819
Query: 603 VIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHL----EEQ 658
+ + K+ + K +K + K N L+ AQ L++T +++ ++L EEQ
Sbjct: 820 ELLKVANKEKTVQDLKQEIK----ALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
Query: 659 LKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK-------RQLEQKI 711
+ + L+ + L + + L+ ++ L+ +E+ + K+ +LE +
Sbjct: 876 MNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVL 935
Query: 712 SSKLGSLKLMEQDTCNLEEEERKASTKIKEI-NVQ-KAKLVTELTNLIKICTSLHIQKVD 769
K LK +E L+E E S+K + + +VQ + KL +K
Sbjct: 936 KEKENELKRLE---AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
Query: 770 LILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNL 829
+ VISE+ K S L+ +H + + + + + E + ++
Sbjct: 993 PHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD 1052
Query: 830 GAEQTLPQEYQTQVPTIPNGHNSSLPMVFQ--DLPNTLDEIDALLTEERSRASCFTGLNP 887
+T +E Q QV + L +F +P+ L + L E+ C G +
Sbjct: 1053 KVNKT-SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1111
Query: 888 T----IVQEYTKREEEIEQL----TEELKGKKVE----LDQYRENISQVKERWLNPLKEL 935
+ +++ K +E+ L E+ K E L + + ++ Q + +W + E
Sbjct: 1112 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1171
Query: 936 VEKINEKFSNFFSSMQCAGEVD-LHTENEE 964
+ I + S+F SS Q E++ L +EN++
Sbjct: 1172 HKTIKQMQSSFTSSEQ---ELERLRSENKD 1198
Score = 73.9 bits (180), Expect = 8e-13
Identities = 159/785 (20%), Positives = 318/785 (40%), Gaps = 127/785 (16%)
Query: 194 ELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERF 253
++ T S+ E+HK + EK+KQ++ + ++ + E K
Sbjct: 591 QIAAQTSASVLAEELHKV------IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMN 644
Query: 254 YERKRHLDLIEMLEAKRPWVEYE------NVRQEYEEVKLVRDRVKEEV-RKLKEGQIPV 306
+ K + ++ L ++ +E +V + ++++L+ ++++ E+ K++E +I +
Sbjct: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI-L 703
Query: 307 TCRIEEMENERHNLEARIKEKAT-DIKEASQKCKQKQDVIERKDKHIEEL---------- 355
+ + +++E L+ + E+ D+ E +KC Q++D K K +EEL
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD---EKLKTVEELLETGLIQVAT 760
Query: 356 ------------------QQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQ 397
Q L KQN+++ + +K+I + ++K+ E E L+
Sbjct: 761 KEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE--ELLE 818
Query: 398 PQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEK-EKKSVDDHIVRFDNLMNQKEDK- 455
++ + N + +QD K E + + + LEK ++ S+ + NL+ KE++
Sbjct: 819 AELLKVANKEKTVQDLKQ--EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
Query: 456 ------LRQRFRDTYDAVLWLRN---NRDKFKQRVCEPIMLTINMKDNKNAKYIEN---- 502
L ++ +D + WL++ + K V E + N+K+ +A E
Sbjct: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE--VAQHNLKEASSASQFEELEIV 934
Query: 503 -HIPSNDLR---AFVFESQEDME---VFLKEVRDNKKLRVNAVIAPKSSYADKAPS---- 551
N+L+ A + E + D+ L++V+D KL + + K +A S
Sbjct: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
Query: 552 ------RSLNELKQYGFFSYLRELFDAPDPVM----SYLCCQYHIHEVPVGTEKTRERIE 601
S E + G ++ L L DA + + E TEK +
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054
Query: 602 RVIQETRLKQIYTAE-EKYVVKTSFYSNKVISSNTSL---------KVAQFLTVTVDLEQ 651
+ R +Q+ E E V + + SN S K + + T E+
Sbjct: 1055 NKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1114
Query: 652 RRHLEEQLK---EIHRKLQ----------AVDSGLIALRETSKHLEHKDNELRQKKKELL 698
+ LE +LK E+H LQ A G+ L++ + +E ++N+ + K E
Sbjct: 1115 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI--LQKLQRSVEQEENKWKVKVDE-- 1170
Query: 699 ERKTKKRQLEQKISS--KLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNL 756
KT K+ SS +L L+ +D NL E ++++ ++++ VTE+ L
Sbjct: 1171 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1230
Query: 757 IKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH-----FIELDENRQR 811
+ T L + D + E N L++ ++LR TEQ+ +L + +Q
Sbjct: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR-TEQNERQKVAGDLHKAQQS 1289
Query: 812 LLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDAL 871
L +++K A + P+ ++ T+ + SL L L ++
Sbjct: 1290 LELIQSKIVKAAGDTTVIENSDVSPETESSEKETM----SVSLNQTVTQLQQLLQAVNQQ 1345
Query: 872 LTEER 876
LT+E+
Sbjct: 1346 LTKEK 1350
Score = 53.9 bits (128), Expect = 8e-07
Identities = 128/648 (19%), Positives = 256/648 (39%), Gaps = 101/648 (15%)
Query: 133 NLVITREIDVAK---NQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAK 189
N +T+E+ K N F + +K++ EK K+ +
Sbjct: 772 NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEK----------------DGKIKSVEE 815
Query: 190 LSKIELLEATEKSIGPPEMHKYHCELKNLREK------EKQLETSCKEKTEYLQKMVQRN 243
L + ELL+ K ++ + E+K L+E+ EK + S K + LQ +++
Sbjct: 816 LLEAELLKVANKEKTVQDLKQ---EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK 872
Query: 244 ERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVK-----LVRDRVKEEVRK 298
E ++ E K + L W++ ++++E E +K + + +KE
Sbjct: 873 EEQMNTMKAVLEEKE-----KDLANTGKWLQ--DLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 299 LKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEEL--- 355
+ ++ + ++E ENE LEA +KE+ +D+ +Q + QD + IE+L
Sbjct: 926 SQFEELEIV--LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 983
Query: 356 --QQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDE 413
QQA +EEL + I K I L NEL + ++ Q + + NDLR E
Sbjct: 984 NYQQASSFPPHEEL--LKVISEREKEISGLWNELDSLKDAVEHQRKKN---NDLREKNWE 1038
Query: 414 --KALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLR 471
+AL E + + + +T ++ ++ V+ + ++ + K+ +Y WL
Sbjct: 1039 AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGE--WLH 1096
Query: 472 NNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQ-EDMEVFLKEVRDN 530
K K+ + ++ K +E+ + D + + + E + L E
Sbjct: 1097 GFEKKAKECMA-------GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI 1149
Query: 531 KKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVP 590
+ +V ++ + K S +KQ ++ F + + + L + E
Sbjct: 1150 LQKLQRSVEQEENKWKVKV-DESHKTIKQ------MQSSFTSSEQELERLRSENKDIE-- 1200
Query: 591 VGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLE 650
+ RE +E + EK ++ S Y +V ++ LT E
Sbjct: 1201 -NLRREREHLEMEL------------EKAEMERSTYVTEV------RELKDLLT-----E 1236
Query: 651 QRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQK 710
++ L++ E R+ + ++ L ET L + NE ++ +L + + ++ K
Sbjct: 1237 LQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1296
Query: 711 ISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIK 758
I G ++E + E E + T +N + VT+L L++
Sbjct: 1297 IVKAAGDTTVIENSDVSPETESSEKETMSVSLN----QTVTQLQQLLQ 1340
Score = 41.2 bits (95), Expect = 0.005
Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 24/269 (8%)
Query: 661 EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK-RQLEQKISSKLGSLK 719
+IH Q + ++ + +E + L+Q+ L + + QLE K S++L L+
Sbjct: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLR 452
Query: 720 LMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVIS 779
QD L E + + K+++ VQK N + T L +Q + + V S
Sbjct: 453 ---QDYARLVNELTEKTGKLQQEEVQK-------KNAEQAATQLKVQLQEAERRWEEVQS 502
Query: 780 EKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEY 839
K +++ AA L + F+ + Q L K + + +Q+ EQ L Q
Sbjct: 503 YIRKRTAEHEAAQQDL---QSKFVAKENEVQSLHSKLTDTLVSKQQL-----EQRLMQLM 554
Query: 840 QTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTG---LNPTIVQEYTKR 896
+++ + SL M QD+ + + A + + S+ + T L + + ++
Sbjct: 555 ESEQKRV--NKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK 612
Query: 897 EEEIEQLTEELKGKKVELDQYRENISQVK 925
+++I+Q + L ++ L E + ++
Sbjct: 613 DKQIKQTEDSLASERDRLTSKEEELKDIQ 641
Score = 40.8 bits (94), Expect = 0.007
Identities = 134/670 (20%), Positives = 267/670 (39%), Gaps = 121/670 (18%)
Query: 386 ELKTTENCENLQPQIDAITNDLRRIQ--DEKALCEGEIIDKRRERETLEKE--KKSVDDH 441
+LKT + EN + + L+ + +++ALC ++D +E+ + ++ KKS
Sbjct: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALC---VVDLLKEKSGVIQDALKKSSKGE 326
Query: 442 IVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPI-------MLTINMKDN 494
+ + + +K DKL ++ A +D+ KQ E + ++ MKD
Sbjct: 327 LTTLIHQLQEK-DKLLAAVKEDAAAT------KDRCKQLTQEMMTEKERSNVVITRMKDR 379
Query: 495 KNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSL 554
E+++ N + E+Q+ M++ ++VR+ + + A + ++ A S +
Sbjct: 380 IGTLEKEHNVFQNKIHVSYQETQQ-MQMKFQQVREQMEAEI-AHLKQENGILRDAVSNTT 437
Query: 555 NEL--KQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
N+L KQ + LR Q + V TEKT + + +Q+ +Q
Sbjct: 438 NQLESKQSAELNKLR---------------QDYARLVNELTEKTGKLQQEEVQKKNAEQ- 481
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
+ T LKV QL+E R+ + V S
Sbjct: 482 --------------------AATQLKV------------------QLQEAERRWEEVQSY 503
Query: 673 LIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEE 732
+ + T++H E +L+ K + ++ + + L K++ L S + +EQ L E E
Sbjct: 504 I--RKRTAEH-EAAQQDLQSK---FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557
Query: 733 RKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVD------LILQNTTVISEKNK--L 784
+K K + + +Q ++ + L H Q L + VI+EK+K
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
Query: 785 ESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVP 844
+++ AS + RLT + D L K + +++ + + N A E Q
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALANEQAAAAHELEKMQQSV 675
Query: 845 TIPNGHNSSLPMVFQ-DLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKRE--EEIE 901
+ + L Q ++ N ++E L + ++ S L T+V E ++ E++E
Sbjct: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ-TLVSEQPNKDVVEQME 734
Query: 902 QLTEELKGKKVELDQYRE-NISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT 960
+ +E K +++ E + QV + +E + I + S+ +Q DL
Sbjct: 735 KCIQEKDEKLKTVEELLETGLIQVATK-----EEELNAIRTENSSLTKEVQ-----DLKA 784
Query: 961 ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE 1020
+ + +V F S + + H + G +SV +L L+ N+ + V +
Sbjct: 785 KQND---------QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK--EKTVQD 833
Query: 1021 INQGMDPINE 1030
+ Q + + E
Sbjct: 834 LKQEIKALKE 843
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 77.4 bits (189), Expect = 7e-14
Identities = 168/886 (18%), Positives = 363/886 (40%), Gaps = 129/886 (14%)
Query: 157 TQKIVEEKVAALNI-QVGNLCQFLPQD---KVGEFAKL-SKIELLEATEKSIGPPEMHKY 211
+QK+ E + N ++ CQ L +D K E L S+I L+ + + +
Sbjct: 265 SQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSER 324
Query: 212 HCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRP 271
+ E+ +L+ + + L+ + + + + + V++ E HL + K
Sbjct: 325 NSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLK--SQNKDKDH 382
Query: 272 WVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVT-CRIEEMENERHNLEARIKEKATD 330
+E R + +L ++ E+R+ +E ++ + +I++ME E L A +++ T+
Sbjct: 383 QLEALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTE 442
Query: 331 IKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTT 390
Q VI R + ++++ L +L + + +GN +I+ N +
Sbjct: 443 -----------QSVISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKI--NLERAV 489
Query: 391 ENCENLQPQIDAITNDLRRIQDEKALCEGEIIDK-----------RRERETLEKEKKSVD 439
E+ + Q+ T + +K + + ++I+K ++++ TL+KE +
Sbjct: 490 GQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQ--- 546
Query: 440 DHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIM-LTINMKDNKNAK 498
L N K++ +T + + LR + D C+ M ++ D K
Sbjct: 547 --------LSNSKQE-------ETTENIEKLRTSLDS-----CQACMKISCCSHDLKKEV 586
Query: 499 YIENHI----PSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSL 554
+ H+ P + L+ V + +L+EV ++L + I P S D+ S
Sbjct: 587 DLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEV---EQLLRDLGILPSSPNKDQVQQFSG 643
Query: 555 N----------------------ELKQYGFFSYLRELFDAPD---PVMSYLCCQYHIHEV 589
N E + G + D + + Y+ + + +
Sbjct: 644 NSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKE 703
Query: 590 PVGTEKTR-ERIERVI-QETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTV 647
+ E+ R + +E ++ Q+ + +EK VK + + ++A+ V
Sbjct: 704 TLEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLE 763
Query: 648 D--LEQRRHLEEQLKEIHRKLQAVDSGLIALRETS-------------------KHLEHK 686
++R +E L+ RK+Q +++ L +E S K ++
Sbjct: 764 SSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDL 823
Query: 687 DNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQK 746
+N L ++K+EL ++ K+ L K+S +L ++E+ E KA + ++N
Sbjct: 824 ENRLTKQKEELELKEQKEDVLNNKLSD---ALAMVEETQKTKATESLKAESLALKLNETL 880
Query: 747 AKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELD 806
A+L T T +I + L +Q+ + S+++ E + M Q++ Q + L+
Sbjct: 881 AELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLE 940
Query: 807 ENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTI-PNGHNSSLPMVFQDLPNTL 865
E Q++ Q K++ ++ L P+E + Q P + P +S+ M ++ L +
Sbjct: 941 EKLQKVTQHHKKI---EGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHL---I 994
Query: 866 DEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTE----ELKGKKVELDQYRENI 921
D++ A E S+ L + + +++ + +L E EL+ V + Q + +
Sbjct: 995 DDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKEL 1054
Query: 922 SQVKERWLNPLKELVEKINEKFSNFFSSMQCAGE---VDLHTENEE 964
S +KE+ + + LVEK + + +++ + E + L+TE E+
Sbjct: 1055 SVLKEK-MAQMSSLVEKKDRELKALEEALRASQEKHRLQLNTEKEQ 1099
Score = 52.0 bits (123), Expect = 3e-06
Identities = 127/670 (18%), Positives = 267/670 (39%), Gaps = 80/670 (11%)
Query: 122 MVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLPQ 181
M E+E A + + I KN+ + ++ T + +EE++A + L
Sbjct: 712 MQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQK-------EVLES 764
Query: 182 DKVGEFAKLSKIELLEATEKSIGPPEMH----KYHCELKNLREKEKQLETSCKEKTEYLQ 237
E K E LE+ ++ + E H K E EK K E KEK + +Q
Sbjct: 765 SIAHEKRKAK--EALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKK-VQ 821
Query: 238 KMVQRNERYKQDVERFYERKRHL-----DLIEMLEAKRPWVEYENVRQEYEEVKLVRDRV 292
+ R + K+++E +++ L D + M+E + E+++ E +KL
Sbjct: 822 DLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLA 881
Query: 293 KEEVRKLKEGQIP---------VTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQD 343
+ E K K + V +E E++RH E I E IK+ +Q ++
Sbjct: 882 ELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEE 941
Query: 344 VIERKDKHIEELQ-QALIVKQNEELDRQRRIGN------TRKMIEDLQNE------LKTT 390
+++ +H ++++ + +K N+ ++ R + T +D+ E L
Sbjct: 942 KLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQ 1001
Query: 391 ENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRR---ERETLEKEKKSVDDHIVRFDN 447
+ + Q I + DL + GE+ +K++ E+ + +++S + +++
Sbjct: 1002 KEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLK--E 1059
Query: 448 LMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSN 507
M Q + ++ R+ LR +++K + + + K K + + +
Sbjct: 1060 KMAQMSSLVEKKDRELKALEEALRASQEKHRLQ----LNTEKEQKPRKKTQTCDTSVQIE 1115
Query: 508 DLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLR 567
+ F S ++ + F K R VI + ++L+EL+ + ++
Sbjct: 1116 PVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVI--------QRQKKALSELR-----ARIK 1162
Query: 568 ELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYS 627
EL A P + H+ + R+E +Q+ L ++
Sbjct: 1163 ELEKARSP-------DHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLSRIEILAPQ 1215
Query: 628 NKVISS--NTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVD--SGLIALRETSKHL 683
N + ++ ++++ + + V LE L + + L + SG ++++ S+
Sbjct: 1216 NGLCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQE 1275
Query: 684 EHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEIN 743
K N+LRQ+ +L+ K QL+ ++ K L+ E+D E+ R++ I+
Sbjct: 1276 REKVNQLRQRDLDLVFDKI--TQLKNQLGRKEELLRGYEKDV----EQLRRSKVSIEMYQ 1329
Query: 744 VQKAKLVTEL 753
Q AKL ++
Sbjct: 1330 SQVAKLEDDI 1339
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 76.6 bits (187), Expect = 1e-13
Identities = 142/743 (19%), Positives = 284/743 (38%), Gaps = 110/743 (14%)
Query: 216 KNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVER------------FYERKRHLDLI 263
+ LR + +QL +S K+K + L+++ ++ E +QD + ER L +
Sbjct: 547 QGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL 606
Query: 264 EMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEME-------NE 316
E LE ++ + E ++Q+ + RD + V + + + ++ ++EE++ E
Sbjct: 607 EALEKEKA-AKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
Query: 317 RHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNT 376
+H +A++ E ++ QK +K+ V + KD+ E+LQ
Sbjct: 666 QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA------------------- 706
Query: 377 RKMIEDLQNELKTTENC--ENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKE 434
L+ LK T+ E + DA+ R I + KA + +RER+ LE+E
Sbjct: 707 ------LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760
Query: 435 KKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDN 494
+ R L + + R+ +A+ + +Q V E +D+
Sbjct: 761 RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 495 KNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSL 554
+ + + L +E+ E +E+++ K+ +A S+++ SR
Sbjct: 821 QQEEAQYGAMFQEQLMTL----KEECEKARQELQEAKE-----KVAGIESHSELQISRQQ 871
Query: 555 NELKQY--GFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
NEL + L+++ + + E T K R+E ++++ +Q
Sbjct: 872 NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG-EQQ 930
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
TA + V + + ++ Q LEEQ QA
Sbjct: 931 ETASRELVKEPARAGDR---------------------QPEWLEEQQGRQFCSTQA---- 965
Query: 673 LIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEE 732
AL+ + E NEL + + L+E + ++++ + E++ L +E
Sbjct: 966 --ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ----------QEREVARLTQER 1013
Query: 733 RKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAAS 792
+A + +A+L L N +L+ Q+V+ + + E +
Sbjct: 1014 GRAQADLALEKAARAELEMRLQN------ALNEQRVEFATLQEALAHALTEKEGKDQELA 1067
Query: 793 SQLRLTEQHFIELDENRQRLLQKCKELMKRARQ-VCNLGAEQTLPQEYQTQVPTIP--NG 849
L EL+E RQ + Q ++L K+ ++ GA+ + P +
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRA 1127
Query: 850 HNSSLPMVFQDLPNTLDEIDALLTEER-SRASCFTGLNPTIVQEYTKREEEIEQLTEELK 908
S L Q D ++ L ER SRA + L T+ + ++ +E+ L
Sbjct: 1128 EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE-TLQGQLEEKAQELGHSQSALA 1186
Query: 909 GKKVELDQYRENI---SQVKERW 928
+ EL +R + S+ ++ W
Sbjct: 1187 SAQRELAAFRTKVQDHSKAEDEW 1209
Score = 56.2 bits (134), Expect = 2e-07
Identities = 105/572 (18%), Positives = 235/572 (41%), Gaps = 58/572 (10%)
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML 266
+M + +L + R +LE E + L + + +Q ++R L L+
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDR-------LALLNEK 267
Query: 267 EAKRPWV--EYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARI 324
+A P E E +R + E + + ++ + LK + + +I ++ E +L ++
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL 327
Query: 325 KEKATDIKEASQKCKQKQDVI-ERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDL 383
+E A+ ++ Q QD + E ++H + Q E L++Q ++ +++ L
Sbjct: 328 REFASHLQ-------QLQDALNELTEEHSKATQ--------EWLEKQAQL--EKELSAAL 370
Query: 384 QNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIV 443
Q++ E E LQ ++ + L ++QD +GE++ + ETL++E + +
Sbjct: 371 QDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT-----L 425
Query: 444 RFDNLMNQKEDKLRQRFRDTYDA-VLWLRNNRDKFKQRVCEPI----MLTINMKDNKNAK 498
+N Q ++ + R +A +L R + ++ KQ++ I N+ K
Sbjct: 426 AANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL 485
Query: 499 YIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELK 558
+ L A V ++ ++ + K A A + E
Sbjct: 486 EQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA 545
Query: 559 QYGFFSYLRELFDAPDPVMSYL---------CCQYHIHEVPVGTEKTRERIERVIQETRL 609
G + +L + L Q H ++ E+ + ++ L
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE--RDAAL 603
Query: 610 KQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAV 669
KQ+ E++ K ++ +N + AQ +VT ++ L +++E+ V
Sbjct: 604 KQLEALEKEKAAKLEILQQQLQVANEARDSAQ-TSVTQAQREKAELSRKVEELQ---ACV 659
Query: 670 DSGLIALRETSKHLEHKDNELRQKKKELLERK---TKKRQLEQKISSKLGSLKLMEQDTC 726
++ E + + +LR ++++ E++ +K QL++++ + SLK+ +
Sbjct: 660 ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG--- 716
Query: 727 NLEEEERKASTKIKEINVQKAKLVTELTNLIK 758
+LEEE+R+A+ ++E ++L E +L++
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVE 748
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/281 (19%), Positives = 115/281 (40%), Gaps = 26/281 (9%)
Query: 153 KKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYH 212
+K+ + VEE A ++ Q Q +V E + E +ATEK E +
Sbjct: 644 EKAELSRKVEELQAC--VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 213 CELKNLREKEKQLETSCKEKTE------------------YLQKMVQRNERYKQDVERFY 254
+L+ L+E K + S +E+ + +V++++R ++++E
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 255 ERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEME 314
++ L+ + E E +R+E E + + E +L + R E+ +
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 315 NERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIG 374
E A +E+ +KE +K +Q+ + K IE + I +Q EL
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH--A 879
Query: 375 NTRKMIEDLQNE----LKTTENCENLQPQIDAITNDLRRIQ 411
N + ++ +Q + K ++ LQ ++ A + ++ R++
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Score = 43.5 bits (101), Expect = 0.001
Identities = 75/334 (22%), Positives = 130/334 (38%), Gaps = 58/334 (17%)
Query: 650 EQRRHLEEQLKEIHRKLQAVDS-GLIALRETSKHLEHKD-NELRQKKKELLER------- 700
E R+ L E+ +I Q +D L+ ++ + LE K+ ELR K + L R
Sbjct: 239 ENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQ 298
Query: 701 ----KTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKL---VTEL 753
KT+K Q+++KI+ L EE S K++E +L + EL
Sbjct: 299 CQDLKTEKSQMDRKINQ--------------LSEENGDLSFKLREFASHLQQLQDALNEL 344
Query: 754 TNLIKICTSLHIQK-VDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDEN---- 808
T T ++K L + + + +K LE +L E+H +L +N
Sbjct: 345 TEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQE 404
Query: 809 RQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPT----------IPNGH----NSSL 854
+ +L +L ++ L A T Q + T GH L
Sbjct: 405 KGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQL 464
Query: 855 PMVFQDLPNTLDEIDALLTEERSRASCFTGLNPT-----IVQEYTKREEEIEQLTEELKG 909
+ DL +++ + EE +AS G T + E T I+Q +EL G
Sbjct: 465 SSLITDLQSSISNLSQA-KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAG 523
Query: 910 KKVELDQYRENISQV---KERWLNPLKELVEKIN 940
K + + + ++Q +E+ L+ VE+++
Sbjct: 524 LKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
Score = 43.1 bits (100), Expect = 0.001
Identities = 130/667 (19%), Positives = 252/667 (37%), Gaps = 129/667 (19%)
Query: 220 EKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFY--ERKRHLDLIEMLEAKRPWVEYEN 277
E++ L +S +E+ L + V E ++++R E ++ L E L + +
Sbjct: 1221 ERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNS 1280
Query: 278 VRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQK 337
R L +EEV+ L+E E+ NL + +A +E Q+
Sbjct: 1281 ARAAERSSAL-----REEVQSLRE-------EAEKQRVASENLRQELTSQAERAEELGQE 1328
Query: 338 CKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQ 397
K Q+ +K +QAL Q E +T+ ++ +L L C+ LQ
Sbjct: 1329 LKAWQEKFFQK-------EQALSTLQLEHT-------STQALVSEL---LPAKHLCQQLQ 1371
Query: 398 PQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKE---- 453
E+A E +R RE LE+ K++ +R + L Q+E
Sbjct: 1372 A--------------EQAAAE------KRHREELEQSKQAAGG--LRAELLRAQRELGEL 1409
Query: 454 DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFV 513
LRQ+ + LR + + ++ ++M + E + L
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQ--------LSMLKKAHGLLAEE---NRGLGERA 1458
Query: 514 FESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAP 573
++ +EV L + R+ + AV A + + + + ++
Sbjct: 1459 NLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE-------------- 1504
Query: 574 DPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISS 633
+ + +Y +V V E+ R + ER +++Q+ + + + S K+ S
Sbjct: 1505 ---LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS 1561
Query: 634 NTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQK 693
+ + KV Q V + +E ++LQA L E L K+
Sbjct: 1562 DQASKVQQQKLKAVQAQGGESQQEA-----QRLQA------QLNELQAQLSQKEQAAEHY 1610
Query: 694 KKELLERKT---KKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLV 750
K ++ + KT K+Q Q++ +L SL+ ++++ L E + ++ Q+A L
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHEL-----QQAGLK 1665
Query: 751 TELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQ 810
T+ + C L ++ LE+ A QLR + + D +
Sbjct: 1666 TKEAE--QTCRHL--------------TAQVRSLEAQVAHADQQLRDLGKFQVATDALKS 1709
Query: 811 RLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVP-TIPNGHNSSLP-----MVFQDLPNT 864
R Q K + + +L E+ P +++P T P+G +S+P + Q LP
Sbjct: 1710 REPQ-AKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDG--TSVPGEPASPISQRLPPK 1766
Query: 865 LDEIDAL 871
++ +++L
Sbjct: 1767 VESLESL 1773
Score = 42.7 bits (99), Expect = 0.002
Identities = 60/291 (20%), Positives = 120/291 (41%), Gaps = 37/291 (12%)
Query: 650 EQRRHLEEQLKEIHRKLQAVDSGLIALRET-SKHLEHKDNELRQKKKELLERKTKKRQLE 708
E+ L +L+E LQ + L L E SK + + Q +KEL K+ LE
Sbjct: 318 EENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE 377
Query: 709 QKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKV 768
+K G L +E+ L++ + +K +++ ++ L +L +
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQ----------EKGEVLGDVLQL----ETLKQEAA 423
Query: 769 DLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCN 828
L NT + + LE++ ++L HF +E +Q+L +L + N
Sbjct: 424 TLAANNTQLQARVEMLETERGQQEAKLLAERGHF---EEEKQQLSSLITDLQS---SISN 477
Query: 829 LG-AEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNP 887
L A++ L Q Q H + L L + L ++A + ++ GL
Sbjct: 478 LSQAKEELEQASQ--------AHGARLTAQVASLTSELTTLNATIQQQDQE---LAGLKQ 526
Query: 888 TIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEK 938
++ + + ++Q + +G + +++Q ++ Q +++ LKE+ EK
Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ----LKEVAEK 573
Score = 38.1 bits (87), Expect = 0.046
Identities = 56/240 (23%), Positives = 111/240 (46%), Gaps = 30/240 (12%)
Query: 184 VGEFAKLSK----IELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKM 239
+GE A L + +EL +A EK + + E + L E +++ +++ +E K
Sbjct: 1454 LGERANLGRQFLEVELDQAREKYVQELAAVRADAETR-LAEVQREAQSTARELEVMTAKY 1512
Query: 240 VQRNERYKQDVERFYERKRHLDL-IEMLEAKRPWVEYENVRQEYEEVKLVRDR---VKEE 295
+ ++ +RF E ++ L +E LE + E +Q E K + D K +
Sbjct: 1513 EGAKVKVLEERQRFQEERQKLTAQVEQLEV----FQREQTKQVEELSKKLADSDQASKVQ 1568
Query: 296 VRKLKEGQIP---VTCRIEEMENERHNLEARIKEK---ATDIKEASQKCKQKQDVIERKD 349
+KLK Q + ++ + + L+A++ +K A K +K K D ++++
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQN 1628
Query: 350 KHIEELQQAL--IVKQNEELDRQ-RRIGNTRKMIEDLQNELKTTE---NCENLQPQIDAI 403
+ ++E ++L + K+N+EL + R+G+ E Q LKT E C +L Q+ ++
Sbjct: 1629 QELQEQLRSLEQLQKENKELRAEAERLGH-----ELQQAGLKTKEAEQTCRHLTAQVRSL 1683
Score = 37.0 bits (84), Expect = 0.10
Identities = 53/269 (19%), Positives = 109/269 (40%), Gaps = 31/269 (11%)
Query: 689 ELRQKKKELLERKTKKRQLE-------QKISSKLGSLKLMEQ--DTCNLEEEERKAS--- 736
++R+ KK+L + ++ + +LE + ++ K + +M+Q D L E++ AS
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE 274
Query: 737 -TKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQL 795
+++E+ + L L +K C L +K + + + E L +S L
Sbjct: 275 PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL 334
Query: 796 R--------LTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIP 847
+ LTE+H E ++ Q KEL + L + + Q +Q+
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 848 NGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEE-------- 899
+ + P ++ + +++ L E + A+ T L + T+R ++
Sbjct: 395 SQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAER 454
Query: 900 --IEQLTEELKGKKVELDQYRENISQVKE 926
E+ ++L +L N+SQ KE
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLSQAKE 483
Score = 36.6 bits (83), Expect = 0.13
Identities = 54/301 (17%), Positives = 110/301 (36%), Gaps = 26/301 (8%)
Query: 649 LEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDN--------ELRQKKKELLER 700
L +R H EE+ +++ + + S + L + + LE ++ EL
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 701 KTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIK-EINVQKAKLVTELTNLIKI 759
+Q +Q+++ K + +++ +AS ++ ++ + L + L ++
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 760 CTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKEL 819
+ D Q T E+ + AA QL E+ E Q+ LQ E
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 820 MKRARQVCNLGAEQTLP-----QEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTE 874
A+ + +E Q V T + + V E++ L
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV--------AELELQLRS 682
Query: 875 ERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKE 934
E+ +A+ + QE + +E+++ L E LK K L++ + + E + E
Sbjct: 683 EQQKAT----EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE 738
Query: 935 L 935
L
Sbjct: 739 L 739
Score = 31.2 bits (69), Expect = 5.6
Identities = 37/186 (19%), Positives = 77/186 (41%), Gaps = 23/186 (12%)
Query: 191 SKIELLEATEKSIGPPEMHKYHCELKNL----REKEKQLETSCKEKTEYLQKMVQRNERY 246
+K+++LE E+ E K +++ L RE+ KQ+E K+ + Q + ++
Sbjct: 1515 AKVKVLE--ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
Query: 247 K----------QDVERFYERKRHLD--LIEMLEAKRPW-VEYENVRQEYEEVKLVRDRVK 293
K Q+ +R + L L + +A + ++ E + Y+ K ++
Sbjct: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 294 EEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIE 353
E++R L++ Q +E+ E L +++ KEA Q C+ + + +
Sbjct: 1633 EQLRSLEQLQK----ENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVA 1688
Query: 354 ELQQAL 359
Q L
Sbjct: 1689 HADQQL 1694
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 75.5 bits (184), Expect = 3e-13
Identities = 168/863 (19%), Positives = 354/863 (41%), Gaps = 156/863 (18%)
Query: 189 KLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQ 248
K + ++ EA+EK+I KY CEL+NLR + ++ + + ++Q N +Q
Sbjct: 277 KENLVKQCEASEKNI----QKKYECELENLR----KATSNANQDNQICSILLQENTFVEQ 328
Query: 249 DVERFYERKRHL-DLIEMLEAKRPWVEYENVRQEYEEVKLVRD--RVKEE---------- 295
V E+ +HL D ++ LE++ ++ E ++KL D +K+E
Sbjct: 329 VVN---EKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEF 385
Query: 296 -VRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEE 354
+ +L + C IE++++E L + Q ++ Q + E+ K I E
Sbjct: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQF------CYTVEQHNREVQSLKEQHQKEISE 439
Query: 355 LQQALIV-KQNEELDRQRRIGNTRKMIEDLQNE-LKTTENCENLQPQIDAITNDLRRIQD 412
L + + + E+L I ++ E+LQ E + N E+L+ ++ + +L
Sbjct: 440 LNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL----- 494
Query: 413 EKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRD---TYDAVLW 469
GE K + K++++ D H + + KLR F + + V
Sbjct: 495 ------GESAGKISQEFESMKQQQASDVH---------ELQQKLRTAFTEKDALLETVNR 539
Query: 470 LRNNRDKF--KQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEV 527
L+ +K +Q + + TI KN Y+ S + LKE+
Sbjct: 540 LQGENEKLLSQQELVPELENTIKNLQEKNGVYL--------------LSLSQRDTMLKEL 585
Query: 528 RDNKKLRVNAVIAPKSSYADKAPSRSLNELKQY-----GFFSYLRELFDAPDPVMSYLC- 581
++N++ K + +K S E+ + + EL + + Y
Sbjct: 586 EG----KINSLTEEKDDFINKL-KNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 582 CQYHIHEVPVGTEKT---RERIERVIQETRLKQIYTAEEKYV----VKTSFYSNKVISSN 634
+ ++E+ G E+T +++ ++ +++ ++ +E+K V VK+ + N +SS
Sbjct: 641 LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE 700
Query: 635 TSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQK- 693
++++ L V + ++ L+E + ++ +KLQ + + E + +NE QK
Sbjct: 701 KK-QLSRDLEVFLSQKEDVILKEHITQLEKKLQ------LMVEEQDNLNKLLENEQVQKL 753
Query: 694 --KKEL----------LERKTKKRQLEQKISSKLGSLKLMEQDTCNLE-EEERKASTKIK 740
K +L + ++++ + + + SL + ++ CNL + + K K
Sbjct: 754 FVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEK 813
Query: 741 EINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMA---ASSQLRL 797
EI + + V + L + +KV L + + SEK L+SD + A+ + RL
Sbjct: 814 EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRL 873
Query: 798 TEQHFI-------------ELDENRQRLLQKCKELMK---RARQVCNLGAEQTLPQEYQT 841
Q+ + E+ +++ K E +K +++ + AE L ++
Sbjct: 874 ENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLA 933
Query: 842 QVPTIPNGHNSSLPMVFQDLPN----------TLDEIDALLTEERSRASCFTGLNPTIVQ 891
+ P++ N SS+ + + + N +++I + + + T+ +
Sbjct: 934 KSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKE 993
Query: 892 EYTKREEEIEQLT----------EELKGKKVELDQYRENISQVKERWLNPLKELVEKINE 941
E E +QL+ E K +E ++ E + KER N + +E +
Sbjct: 994 ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKER-ANNFEHRIEDLTR 1052
Query: 942 KFSNFFSSMQCAGEVDLHTENEE 964
+ N S++QC ++++NE+
Sbjct: 1053 QLRN--STLQCE---TINSDNED 1070
Score = 72.8 bits (177), Expect = 2e-12
Identities = 137/662 (20%), Positives = 269/662 (40%), Gaps = 81/662 (12%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQK---MVQRNERYKQDVERFYERKRHLDLIEML 266
K E +NL + +++ +C + + +K ++ +E K +E+ R R +LI +
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLK 929
Query: 267 E--AKRPWVEYE---NVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLE 321
+ AK P V+ + +V++ E+++ + KE+ K+ + ++ +E+++ R +
Sbjct: 930 DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 322 ARIKEKATDIK-EASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQR-RIGNTRKM 379
+KE+ ++ E Q +D+I+ + + L + KQ+E+LD ++ R N
Sbjct: 990 T-VKEELESLRSEKDQLSASMRDLIQGAESYKNLLLE--YEKQSEQLDVEKERANNFEHR 1046
Query: 380 IEDLQNELK-TTENCENLQPQIDAITNDLRRIQDEKALCEGEI---------IDKRRERE 429
IEDL +L+ +T CE + + + + +Q L E +I +DK E E
Sbjct: 1047 IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAE 1106
Query: 430 TLEKEKKSVDDHIVRFDNLMN-----QKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVC-- 482
L+KE+K + +H + L QKE K Q+ + V +
Sbjct: 1107 KLQKEQK-IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADY 1165
Query: 483 EPIMLTINMK-DNKNAKY--IENHIP-----SNDLRAFVFESQEDMEVF----------- 523
E +M +N K NKN K +E I L+ + Q ++ +
Sbjct: 1166 ERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLL 1225
Query: 524 ---LKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYL 580
KE+ D+K+ + +I S + S+ E+ + L E+ + +L
Sbjct: 1226 VKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKI----QLAEITSEKHKIHEHL 1281
Query: 581 CCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVA 640
H+ + + +R+ + +E R + E+ V + F S KV N +
Sbjct: 1282 KTSAEQHQRTLSAYQ--QRVTALQEECRAAKA----EQATVTSEFESYKVRVHNVLKQQK 1335
Query: 641 QFLTVTVDLE----QRRHLEEQLKEIHRKLQAVDSGL-IALRETSKHLEHKDNELRQKKK 695
+ E +R HLE + ++ KLQ + L I + E D L + K
Sbjct: 1336 NKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK 1395
Query: 696 ELLERKTKKRQLEQKISS--------KLGSLKLMEQDTCNLEEEERKASTKIKEINVQKA 747
L E +K+ +L +K+ S K + + Q T E +++ + +
Sbjct: 1396 MLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHR 1455
Query: 748 KLVTELTNLIKICTSLHIQKVDLILQNTT--VISEKNKLESDYMAASSQLRLTEQHFIEL 805
K V L + + + Q L + TT +S + L++ ++ L L + H +
Sbjct: 1456 KTVETLQQQL---SKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR 1512
Query: 806 DE 807
+E
Sbjct: 1513 EE 1514
Score = 72.0 bits (175), Expect = 3e-12
Identities = 166/912 (18%), Positives = 363/912 (39%), Gaps = 115/912 (12%)
Query: 145 NQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQ-----FLPQDKVGEFAKLSKIELLEAT 199
N++F ++K + E + L Q NL Q L + + E ++ + EL E+
Sbjct: 441 NETFLSDSEKEKLTLMFE--IQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESA 498
Query: 200 EKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRH 259
K E K + ++ E +++L T+ EK L+ + R + + E+ ++
Sbjct: 499 GKISQEFESMKQQ-QASDVHELQQKLRTAFTEKDALLETV----NRLQGENEKLLSQQ-- 551
Query: 260 LDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHN 319
+L+ LE +N+ QE V L+ ++ + K EG +I + E+ +
Sbjct: 552 -ELVPELENT-----IKNL-QEKNGVYLLSLSQRDTMLKELEG------KINSLTEEKDD 598
Query: 320 LEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKM 379
++K ++ +KC++++ +I K +E+ ++ N EL+ Q+ T +
Sbjct: 599 FINKLKNSHEEMDNFHKKCEREERLILELGKKVEQT-----IQYNSELE-QKVNELTGGL 652
Query: 380 IEDLQNELKTTENCENLQPQIDAITND-------LRRIQDEKALCEGEIIDKRRERETLE 432
E L+ + + + E L Q+ ++ D ++ + +E E R+ E
Sbjct: 653 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFL 712
Query: 433 KEKKSV--DDHIVRFDN---LMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIML 487
+K+ V +HI + + LM +++D L + + L+++ F + + +
Sbjct: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSE 772
Query: 488 TINMKDNKNAKYI--ENHIPSNDLRA-FVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSS 544
KD N E+ N+ + F+ E + KE++ ++ V KS
Sbjct: 773 DSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSL 832
Query: 545 YADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRE------ 598
D + L + L E+ + + S L E+ EKTR
Sbjct: 833 LRDYEQEKVLLRKE-------LEEIQSEKEALQSDLL------EMKNANEKTRLENQNLL 879
Query: 599 -RIERVIQETRLKQIYTAEEKYVVKTS-------------------FYSNKVISSNTSLK 638
++E V Q +I+ +EK +K ++ + S+K
Sbjct: 880 IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVK 939
Query: 639 VAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELL 698
+V E+ +LE++ KE K+ + L+A++ K L+ E + K+EL
Sbjct: 940 NDPLSSVKELEEKIENLEKECKEKEEKINKIK--LVAVK-AKKELDSSRKETQTVKEELE 996
Query: 699 ERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAK---LVTELTN 755
+++K QL + + + + E++ + + + N + + L +L N
Sbjct: 997 SLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRN 1056
Query: 756 LIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQK 815
C +++ DL+ + T+ S LE + + ++ EL+ + + QK
Sbjct: 1057 STLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDK---ELEAEKLQKEQK 1113
Query: 816 CKELMKRARQV----CNLGAEQTLPQEYQTQVPTIPNGHNSS--LPMVFQDLPNTLDEID 869
KE ++ L E+ Q+ ++ + + + M D + E++
Sbjct: 1114 IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173
Query: 870 ALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWL 929
LT + ++ + QE ++++ E L EE+ + + QY E +++K+ +
Sbjct: 1174 QKLTNKNNKIE-------DLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLV 1226
Query: 930 NPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPH 989
KEL + + + GE++ +++ + Y I++ +++ H++ H
Sbjct: 1227 KTKKELADSKQAETDHLILQASLKGELE---ASQQQVEVYKIQLA---EITSEKHKIHEH 1280
Query: 990 HQSGGERSVSTM 1001
++ E+ T+
Sbjct: 1281 LKTSAEQHQRTL 1292
Score = 58.2 bits (139), Expect = 4e-08
Identities = 172/853 (20%), Positives = 324/853 (37%), Gaps = 170/853 (19%)
Query: 211 YHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKR 270
Y E++NL+ + + + E LQK ++ L+L E L+ +
Sbjct: 127 YVKEIENLKNELMAVRSKYSEDKANLQKQLEE------------AMNTQLELSEQLKFQN 174
Query: 271 PWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATD 330
+NV++ EE++ +R +E++ L++ L+A EK
Sbjct: 175 N--SEDNVKKLQEEIEKIRPGFEEQILYLQK-----------------QLDATTDEK--- 212
Query: 331 IKEASQKCKQKQDVIERKDKHI--------EELQQALIVKQNEELDRQRRIGNTRKMIED 382
+ Q Q++IE +H EEL Q + Q E + +I + K E
Sbjct: 213 ----KETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEA 268
Query: 383 LQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHI 442
N+L E ENL Q +A ++++ K CE E + K + + S+ +
Sbjct: 269 EINKL--NELKENLVKQCEASEKNIQK----KYECELENLRKATSNANQDNQICSI---L 319
Query: 443 VRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIEN 502
++ + + E + ++ + D + L + K V M + +K +A++I++
Sbjct: 320 LQENTFV---EQVVNEKVKHLEDTLKELESQHSILKDEV--TYMNNLKLKLEMDAQHIKD 374
Query: 503 HIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSS---------YADKAPSRS 553
F +ED+E + E+ K+ + + KS Y + +R
Sbjct: 375 EF---------FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNRE 425
Query: 554 LNELKQ--YGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQ 611
+ LK+ S L E F D L + I G ++ E +++ QE L
Sbjct: 426 VQSLKEQHQKEISELNETF-LSDSEKEKLTLMFEIQ----GLKEQCENLQQEKQEAILNY 480
Query: 612 IYTAEEKYVVKTSF--YSNKVISSNTSLKVAQFLTVTVDLEQRRHL----EEQLKEIHRK 665
E +++T + K+ S+K Q V +L+Q+ ++ L E +
Sbjct: 481 ESLREIMEILQTELGESAGKISQEFESMKQQQASDVH-ELQQKLRTAFTEKDALLETVNR 539
Query: 666 LQAVDSGLIALRETSKHLEHKDNELRQKK----KELLERKTKKRQLEQKISSK------- 714
LQ + L++ +E LE+ L++K L +R T ++LE KI+S
Sbjct: 540 LQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDF 599
Query: 715 LGSLKLMEQDTCNL----EEEER------------------------------KASTKIK 740
+ LK ++ N E EER + + K K
Sbjct: 600 INKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEK 659
Query: 741 EINVQK-AKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLR--L 797
+ N QK KL+ ++ L + L + L +N + SEK +L D SQ +
Sbjct: 660 DQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719
Query: 798 TEQHFIELDENRQRLLQKCKELMKRARQ---------------VCNLGAEQTLPQEYQTQ 842
++H +L++ Q ++++ L K + +G+E + E +
Sbjct: 720 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE-EKD 778
Query: 843 VPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQ 902
V + SL + ++ N + D + E C + +E + EE++
Sbjct: 779 VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC-------LQEESVVQCEELKS 831
Query: 903 LTEELKGKKVELDQYRENISQVKERWLNPLKELV---EKINEKFSNFFSSM----QCAGE 955
L + + +KV L + E I KE + L E+ EK + N + Q +
Sbjct: 832 LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSK 891
Query: 956 VDLHTENEEDYDK 968
++H E E+ + K
Sbjct: 892 SEIHNEKEKCFIK 904
Score = 49.3 bits (116), Expect = 2e-05
Identities = 134/707 (18%), Positives = 272/707 (38%), Gaps = 136/707 (19%)
Query: 293 KEEVRKLKEGQIPVT----CRIEEMENERHNLEAR-IKEKATDIKEAS---------QKC 338
KE++ K + Q+ + R E+E E L ++ + E DI +A +K
Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86
Query: 339 KQKQDVIERKDKHI---EELQQALIVKQNEELDRQRRIGNTRKMIEDLQNEL-----KTT 390
+ +Q + K ++I +E++ ++ + + ++ N K IE+L+NEL K +
Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYS 146
Query: 391 ENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMN 450
E+ NLQ Q++ N + ++ K + + +D++ + +
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQL------------------KFQNNSEDNVKK----LQ 184
Query: 451 QKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLR 510
++ +K+R F + +L+L+ D E + N+ + + Y +N
Sbjct: 185 EEIEKIRPGFE---EQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN-------- 233
Query: 511 AFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELF 570
S ++ + LK + + + I S+ +A LNELK+ + +++
Sbjct: 234 ---INSLQEELLQLKAIHQEEVKELMCQI-EASAKEHEAEINKLNELKE----NLVKQCE 285
Query: 571 DAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKV 630
+ + C+ E R+ Q+ ++ I E +V +V
Sbjct: 286 ASEKNIQKKYECE---------LENLRKATSNANQDNQICSILLQENTFV-------EQV 329
Query: 631 ISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLE------ 684
++ E+ +HLE+ LKE+ + + + + LE
Sbjct: 330 VN-----------------EKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI 372
Query: 685 -----HKDNELRQKKKELLERKTKKRQLEQKISSKLGSLK-----LMEQDTCNLEEEERK 734
H+ +L K ELL K ++ + +K+ S+L L +EQ ++ + +
Sbjct: 373 KDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQ 432
Query: 735 ASTKIKEIN--------VQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLES 786
+I E+N +K L+ E+ L + C +L +K + IL ++ L++
Sbjct: 433 HQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQT 492
Query: 787 DYMAASSQL-----RLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQT 841
+ ++ ++ + +Q ++ E +Q+L E V L E Q
Sbjct: 493 ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQE 552
Query: 842 QVPTIPN------GHNSSLPMVFQDLPNTLDEIDA---LLTEERSRASCFTGLNPTIVQE 892
VP + N N + L E++ LTEE+ + +
Sbjct: 553 LVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDN 612
Query: 893 YTKREEEIEQLTEELKGKKVELD-QYRENISQVKERWLNPLKELVEK 938
+ K+ E E+L EL GKKVE QY + Q L+E +++
Sbjct: 613 FHKKCEREERLILEL-GKKVEQTIQYNSELEQKVNELTGGLEETLKE 658
Score = 39.3 bits (90), Expect = 0.021
Identities = 72/355 (20%), Positives = 143/355 (40%), Gaps = 51/355 (14%)
Query: 115 KRGCSRGMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGN 174
K+ + M E+EL + +++A + K + +K+ N ++ +
Sbjct: 1135 KKQLQKTMQELELVKKDAQQTTLMNMEIADYERL---------MKELNQKLTNKNNKIED 1185
Query: 175 LCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREK-EKQLETSCKEKT 233
L Q + K + +I L+++ + + + + ++K L K +K+L S + +T
Sbjct: 1186 LEQEIKIQKQKQETLQEEITSLQSSVQ-----QYEEKNTKIKQLLVKTKKELADSKQAET 1240
Query: 234 EYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEY--ENVRQEYEEVKLVRDR 291
++L ++Q + + + + + + L E+ K E+ + Q + + R
Sbjct: 1241 DHL--ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
Query: 292 V---KEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERK 348
V +EE R K Q VT E + HN+ + K K+ E ++ KQ+++
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE-TEGAKQERE----- 1352
Query: 349 DKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELK-TTENCENLQPQIDAITNDL 407
H+E L L +K ++D QN L+ + LQ + D +
Sbjct: 1353 --HLEMLIDQLKIK-----------------LQDSQNNLQINVSELQTLQSEHDTLLERH 1393
Query: 408 RRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRD 462
++ E E E+ +K ++ KS +H L +Q E LR FRD
Sbjct: 1394 NKMLQETVSKEAELREKLCSIQSENMMMKS--EHTQTVSQLTSQNE-VLRNSFRD 1445
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 75.5 bits (184), Expect = 3e-13
Identities = 156/866 (18%), Positives = 345/866 (39%), Gaps = 112/866 (12%)
Query: 184 VGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKT--EYLQKMVQ 241
+GE + K EL + + + E+ + + +K ET E E QK Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 242 RNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKE 301
E + +E+F K +LD + +E EN + E+R L +
Sbjct: 1204 AVEELTEQLEQFKRAKANLD------KNKQTLEKENAD------------LAGELRVLGQ 1245
Query: 302 GQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIV 361
+ +E+E+++ LEA+++E + + + + D + + +E + L
Sbjct: 1246 AK-------QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 362 KQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEI 421
+ + + + + + ++D Q EL E + L ++ LR++++E+ + ++
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLN-----VSTKLRQLEEERNSLQDQL 1352
Query: 422 IDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRV 481
++ ++ LE+ HI + ++ + KL Q F T +A+ ++ K+R
Sbjct: 1353 DEEMEAKQNLER-------HISTLNIQLSDSKKKL-QDFASTVEAL-------EEGKKRF 1397
Query: 482 CEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVR------DNKKLRV 535
+ I + K A Y + N L+ + +D+ V L R + K+ +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQ----QELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 536 NAVIAPK----SSYAD-----KAPSRSLNELKQYGFFSYLRELFDA-------------- 572
+ ++A + S YAD +A +R E K L E +A
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEARE-KETKALSLARALEEALEAKEELERTNKMLKAE 1512
Query: 573 -PDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVI 631
D V S ++HE+ EK++ +E ++E + + +E + + +V
Sbjct: 1513 MEDLVSSKDDVGKNVHEL----EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 632 SSNTSLKVAQFLTVTVDL--EQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEH--KD 687
+ + L + E+RR L+ QL E +L+ K LE KD
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 688 NELRQ----KKKELLERKTKKRQLEQK-ISSKLGSLKLMEQDTCNLEEEERKASTKIKEI 742
EL+ K +E ++ +K Q + K +L + + +E K K K +
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK---KAKSL 1685
Query: 743 NVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHF 802
+L +L + ++K +L + + +S +N L+ + +++ E+
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 803 IELDENRQRLLQKCKELMKRARQVCN-LGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDL 861
E N + + + ++ ++A Q+ N L E++ Q+ ++ + N L ++
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-QNKELRSKLHEM 1804
Query: 862 --------PNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVE 913
+T+ ++A + + + + +++++++++ +++ ++
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 914 LDQYRENISQVKERWLNPLKELVEKINEKFSNFFSS-MQCAGEVDLHTENEEDYDKYGIR 972
+QY+E + R + LK +E+ E+ ++ + E+D TE+ E +
Sbjct: 1865 AEQYKEQAEKGNAR-VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 973 IRVKFRSSTQLHELTPHHQSGGERSV 998
++ K R + P +SGG R +
Sbjct: 1924 LKSKLRRGNET-SFVPSRRSGGRRVI 1948
Score = 65.9 bits (159), Expect = 2e-10
Identities = 181/955 (18%), Positives = 370/955 (38%), Gaps = 137/955 (14%)
Query: 92 AICLGLAGKPAFMGRADKVGFF--VKRGCS-----RGMVEIELF-RASGNLVITREIDVA 143
A+C G + AF R ++ ++R C+ R LF + L +TR+ +
Sbjct: 795 AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEM 854
Query: 144 KNQSFWFINKKSTTQKI------VEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLE 197
+ + K QK +E+K + L + NL Q Q + +A+ ++ +
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLT-EEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 198 ATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERK 257
A +K +H+ L+ ++ +QL+ K KM Q
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQ---------------- 950
Query: 258 RHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENER 317
+ LDL E LE E E RQ +++L + + +++KL++ + + + ++ ER
Sbjct: 951 QMLDLEEQLE------EEEAARQ---KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 318 HNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTR 377
LE RI + T++ E +K K ++ + K+KH + + + + EE RQ R
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAK---NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 378 KMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKS 437
K+ D + E +LQ QI + L + ++E + D+ ++ K+ +
Sbjct: 1059 KLEGDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
Query: 438 VDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPI-MLTINMKDNKN 496
++ HI ++ D+ RN +K K+ + E + L ++D +
Sbjct: 1116 LEGHI---------------SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 497 AKYIENHIPSND------LRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAP----KSSYA 546
+ + + + L+ + E E ++E+R V + K + A
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 547 DKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQE 606
+ ++ E + LR L A V E ++++E +QE
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEV-----------------EHKKKKLEAQVQE 1263
Query: 607 TRLK--QIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHR 664
+ K A + K N+V S L A+ + + + L QL++
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL-AKDVASLSSQLQDTQE 1322
Query: 665 KLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQD 724
LQ + + + LE + N L+ + E +E K + ++ +L K QD
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 725 TCN----LEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLIL---QNTTV 777
+ LEE +++ +I+ + Q + L K L + DL++ +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 778 IS--EKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTL 835
+S EK + + D + A + ++ ++ E D +K + + AR + E+ L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEK-NISSKYADERDRAEAEAREKETKALSLARAL-----EEAL 1496
Query: 836 PQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTE-ERSRASCFTGLNPTIVQEYT 894
+ + + N L +DL ++ D++ + E E+S+ + T +
Sbjct: 1497 EAKEELE------RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--------QME 1542
Query: 895 KREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAG 954
+ + ++E+L +EL+ + + N+ +K ++ L+ E+ EK +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH--- 1599
Query: 955 EVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQS---GGERSVSTMLYLMA 1006
+ TE E++ + + K + L +L S G E ++ + L A
Sbjct: 1600 --EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Score = 55.5 bits (132), Expect = 3e-07
Identities = 117/607 (19%), Positives = 234/607 (38%), Gaps = 91/607 (14%)
Query: 155 STTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCE 214
++T + +EE ++ NL Q ++K + KL K + E ++
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQY-EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 215 LKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVE 274
+ NL +K+++ + E+ K +ER + + E + + L L LE
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYA--DERDRAEAEAREKETKALSLARALE------- 1493
Query: 275 YENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEA 334
+ EE++ +K E+ L + V + E+E + LE +++E T ++E
Sbjct: 1494 --EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 335 SQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCE 394
+ + +D R + +++ L K E D Q R D QNE E
Sbjct: 1552 EDELQATEDAKLRLEVNMQAL------KGQFERDLQAR---------DEQNE----EKRR 1592
Query: 395 NLQPQIDAITNDLRRIQDEKALC-------EGEIIDKRRERETLEKEKKSVDDHIVRFDN 447
LQ Q+ +L + ++AL EG++ D + ++ K ++ + +
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 448 LMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSN 507
M + +L + + N K K + + L ++ + A+
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR------KQA 1706
Query: 508 DLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLR 567
DL + + + ++K R+ A IA ++ + +R
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQGNMEAMSDRVR 1760
Query: 568 ELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYS 627
+ + + + L + E R+++ER +E R K E + VK+ F
Sbjct: 1761 KATQQAEQLSNELATE---RSTAQKNESARQQLERQNKELRSK---LHEMEGAVKSKF-- 1812
Query: 628 NKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKD 687
K + K+AQ LEEQ+++ R+ QA +K L+ KD
Sbjct: 1813 -KSTIAALEAKIAQ-------------LEEQVEQEAREKQA----------ATKSLKQKD 1848
Query: 688 NELRQKKKELLERKTKKRQLEQ-KISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQK 746
+L K+ LL+ + +++ EQ K ++ G+ ++ + L+ + +A + + IN +
Sbjct: 1849 KKL---KEILLQVEDERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANR 1900
Query: 747 AKLVTEL 753
KL EL
Sbjct: 1901 RKLQREL 1907
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 75.5 bits (184), Expect = 3e-13
Identities = 156/866 (18%), Positives = 345/866 (39%), Gaps = 112/866 (12%)
Query: 184 VGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKT--EYLQKMVQ 241
+GE + K EL + + + E+ + + +K ET E E QK Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 242 RNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKE 301
E + +E+F K +LD + +E EN + E+R L +
Sbjct: 1211 AVEELTEQLEQFKRAKANLD------KNKQTLEKENAD------------LAGELRVLGQ 1252
Query: 302 GQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIV 361
+ +E+E+++ LEA+++E + + + + D + + +E + L
Sbjct: 1253 AK-------QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 362 KQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEI 421
+ + + + + + ++D Q EL E + L ++ LR++++E+ + ++
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLN-----VSTKLRQLEEERNSLQDQL 1359
Query: 422 IDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRV 481
++ ++ LE+ HI + ++ + KL Q F T +A+ ++ K+R
Sbjct: 1360 DEEMEAKQNLER-------HISTLNIQLSDSKKKL-QDFASTVEAL-------EEGKKRF 1404
Query: 482 CEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVR------DNKKLRV 535
+ I + K A Y + N L+ + +D+ V L R + K+ +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQ----QELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 536 NAVIAPK----SSYAD-----KAPSRSLNELKQYGFFSYLRELFDA-------------- 572
+ ++A + S YAD +A +R E K L E +A
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEARE-KETKALSLARALEEALEAKEELERTNKMLKAE 1519
Query: 573 -PDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVI 631
D V S ++HE+ EK++ +E ++E + + +E + + +V
Sbjct: 1520 MEDLVSSKDDVGKNVHEL----EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 632 SSNTSLKVAQFLTVTVDL--EQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEH--KD 687
+ + L + E+RR L+ QL E +L+ K LE KD
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 688 NELRQ----KKKELLERKTKKRQLEQK-ISSKLGSLKLMEQDTCNLEEEERKASTKIKEI 742
EL+ K +E ++ +K Q + K +L + + +E K K K +
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK---KAKSL 1692
Query: 743 NVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHF 802
+L +L + ++K +L + + +S +N L+ + +++ E+
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 803 IELDENRQRLLQKCKELMKRARQVCN-LGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDL 861
E N + + + ++ ++A Q+ N L E++ Q+ ++ + N L ++
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER-QNKELRSKLHEM 1811
Query: 862 --------PNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVE 913
+T+ ++A + + + + +++++++++ +++ ++
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 914 LDQYRENISQVKERWLNPLKELVEKINEKFSNFFSS-MQCAGEVDLHTENEEDYDKYGIR 972
+QY+E + R + LK +E+ E+ ++ + E+D TE+ E +
Sbjct: 1872 AEQYKEQAEKGNAR-VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 973 IRVKFRSSTQLHELTPHHQSGGERSV 998
++ K R + P +SGG R +
Sbjct: 1931 LKSKLRRGNET-SFVPSRRSGGRRVI 1955
Score = 65.9 bits (159), Expect = 2e-10
Identities = 181/955 (18%), Positives = 370/955 (38%), Gaps = 137/955 (14%)
Query: 92 AICLGLAGKPAFMGRADKVGFF--VKRGCS-----RGMVEIELF-RASGNLVITREIDVA 143
A+C G + AF R ++ ++R C+ R LF + L +TR+ +
Sbjct: 802 AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEM 861
Query: 144 KNQSFWFINKKSTTQKI------VEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLE 197
+ + K QK +E+K + L + NL Q Q + +A+ ++ +
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLT-EEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 198 ATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERK 257
A +K +H+ L+ ++ +QL+ K KM Q
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQ---------------- 957
Query: 258 RHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENER 317
+ LDL E LE E E RQ +++L + + +++KL++ + + + ++ ER
Sbjct: 958 QMLDLEEQLE------EEEAARQ---KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 318 HNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTR 377
LE RI + T++ E +K K ++ + K+KH + + + + EE RQ R
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAK---NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 378 KMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKS 437
K+ D + E +LQ QI + L + ++E + D+ ++ K+ +
Sbjct: 1066 KLEGDASD---FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
Query: 438 VDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPI-MLTINMKDNKN 496
++ HI ++ D+ RN +K K+ + E + L ++D +
Sbjct: 1123 LEGHI---------------SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 497 AKYIENHIPSND------LRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAP----KSSYA 546
+ + + + L+ + E E ++E+R V + K + A
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 547 DKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQE 606
+ ++ E + LR L A V E ++++E +QE
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEV-----------------EHKKKKLEAQVQE 1270
Query: 607 TRLK--QIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHR 664
+ K A + K N+V S L A+ + + + L QL++
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL-AKDVASLSSQLQDTQE 1329
Query: 665 KLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQD 724
LQ + + + LE + N L+ + E +E K + ++ +L K QD
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 725 TCN----LEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLIL---QNTTV 777
+ LEE +++ +I+ + Q + L K L + DL++ +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 778 IS--EKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTL 835
+S EK + + D + A + ++ ++ E D +K + + AR + E+ L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEK-NISSKYADERDRAEAEAREKETKALSLARAL-----EEAL 1503
Query: 836 PQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTE-ERSRASCFTGLNPTIVQEYT 894
+ + + N L +DL ++ D++ + E E+S+ + T +
Sbjct: 1504 EAKEELE------RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--------QME 1549
Query: 895 KREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAG 954
+ + ++E+L +EL+ + + N+ +K ++ L+ E+ EK +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH--- 1606
Query: 955 EVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQS---GGERSVSTMLYLMA 1006
+ TE E++ + + K + L +L S G E ++ + L A
Sbjct: 1607 --EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Score = 55.5 bits (132), Expect = 3e-07
Identities = 117/607 (19%), Positives = 234/607 (38%), Gaps = 91/607 (14%)
Query: 155 STTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCE 214
++T + +EE ++ NL Q ++K + KL K + E ++
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQY-EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 215 LKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVE 274
+ NL +K+++ + E+ K +ER + + E + + L L LE
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYA--DERDRAEAEAREKETKALSLARALE------- 1500
Query: 275 YENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEA 334
+ EE++ +K E+ L + V + E+E + LE +++E T ++E
Sbjct: 1501 --EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 335 SQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCE 394
+ + +D R + +++ L K E D Q R D QNE E
Sbjct: 1559 EDELQATEDAKLRLEVNMQAL------KGQFERDLQAR---------DEQNE----EKRR 1599
Query: 395 NLQPQIDAITNDLRRIQDEKALC-------EGEIIDKRRERETLEKEKKSVDDHIVRFDN 447
LQ Q+ +L + ++AL EG++ D + ++ K ++ + +
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 448 LMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSN 507
M + +L + + N K K + + L ++ + A+
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR------KQA 1713
Query: 508 DLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLR 567
DL + + + ++K R+ A IA ++ + +R
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQGNMEAMSDRVR 1767
Query: 568 ELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYS 627
+ + + + L + E R+++ER +E R K E + VK+ F
Sbjct: 1768 KATQQAEQLSNELATE---RSTAQKNESARQQLERQNKELRSK---LHEMEGAVKSKF-- 1819
Query: 628 NKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKD 687
K + K+AQ LEEQ+++ R+ QA +K L+ KD
Sbjct: 1820 -KSTIAALEAKIAQ-------------LEEQVEQEAREKQA----------ATKSLKQKD 1855
Query: 688 NELRQKKKELLERKTKKRQLEQ-KISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQK 746
+L K+ LL+ + +++ EQ K ++ G+ ++ + L+ + +A + + IN +
Sbjct: 1856 KKL---KEILLQVEDERKMAEQYKEQAEKGNARVKQ-----LKRQLEEAEEESQRINANR 1907
Query: 747 AKLVTEL 753
KL EL
Sbjct: 1908 RKLQREL 1914
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 75.5 bits (184), Expect = 3e-13
Identities = 122/635 (19%), Positives = 262/635 (41%), Gaps = 74/635 (11%)
Query: 217 NLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIE------------ 264
N+R+ + E KE+ + L ++V+ E Q E+ E +R + E
Sbjct: 147 NIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQ 206
Query: 265 -MLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEAR 323
EA R + + E + +E ++++ D + E++ L++ +++ + E LE +
Sbjct: 207 RQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQ-------YVQKSKEELQKLEQQ 259
Query: 324 IKEKATDIKEASQKCKQKQ----DVIERKDKHI--------EELQQALIVKQNEELDRQR 371
+KE+ + A+++ +Q Q + + ++H E Q+AL +K EE Q
Sbjct: 260 LKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQM 319
Query: 372 R--IGNTRKMIEDLQNELKTTENCE-NLQPQIDAITNDLRRIQDEKALCEGEIIDKRRER 428
R IG K+ E + +L TE+ + ++ + + N + ++ E + + R+
Sbjct: 320 RLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAM 379
Query: 429 ETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLT 488
+ L +E+ ++ ++++ N ++ D ++ + + ++N +D+ +++
Sbjct: 380 DELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQ-----RKI 434
Query: 489 INMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADK 548
I + + +YI ++DL V + ED++V ++ D +K + I K
Sbjct: 435 IFHLEKERDRYINQ---ASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ----- 486
Query: 549 APSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETR 608
++L E + Y + L +A D + T+ R+ + Q
Sbjct: 487 --QQNLYEAVRSDRNLYSKNLVEAQDEI----------------TDMKRKLKIMIHQVDE 528
Query: 609 LKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQA 668
LK+ +A+E +VK ++ +LK LE + +E+Q E + L+
Sbjct: 529 LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRI 588
Query: 669 VDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNL 728
+ K L+ +E +L+ R + L +KI + L E
Sbjct: 589 IAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQR 648
Query: 729 EEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDY 788
E+ R +IK++ +K L + N+ ++ + +L+ + T + + +LE
Sbjct: 649 LEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELE--- 705
Query: 789 MAASSQLRLTEQHFIEL-DENRQRLLQKCKELMKR 822
+ L + +E D N L+QK L KR
Sbjct: 706 ----NPLNVHRWRKLEASDPNAYELIQKIHTLQKR 736
Score = 68.6 bits (166), Expect = 3e-11
Identities = 121/638 (18%), Positives = 259/638 (40%), Gaps = 95/638 (14%)
Query: 220 EKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVR 279
+K K+ + KE+ L K+V++ D +H ++ ++L K
Sbjct: 114 QKAKETILALKEEIVNLTKLVEQGSGLSMD--------QHSNIRDLLRFK---------- 155
Query: 280 QEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCK 339
EEV RD++ EV KL+E T + +E E + E I + +I++ +
Sbjct: 156 ---EEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEAS 212
Query: 340 QKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENC-ENLQP 398
++ E+ +K ++++Q + +Q E Q+ + +++ ++ L+ +LK + E
Sbjct: 213 REFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAK 272
Query: 399 QIDAITNDLRRIQDE----KALCEGEIIDKRRERETLEKEKKSVDDHIVRFD-NLMNQKE 453
+++ ++Q E +CE + + +++ LE + K + H +R D +N+
Sbjct: 273 ELEQFQMRNAKLQQENEQHSLVCEQ--LSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
Query: 454 DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFV 513
+++ ++ T D + +++ K ++ +E + ++ +A +
Sbjct: 331 EQIHKKLHHTEDQKAEVEQHKETLKNQIVG----------------LEREVEASKKQAEL 374
Query: 514 FESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAP 573
++ M+ L+E K + AV A + L +L + + E+ +
Sbjct: 375 --DRKAMDELLRERDILNKNMLKAVNATQK-------QTDLVKLHEQAKRNLEGEIQNYK 425
Query: 574 DPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF--YSNKVI 631
D +H+ EK R+R + K + E+ V +T Y K+
Sbjct: 426 DEAQKQRKIIFHL-------EKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIA 478
Query: 632 SSNTSLKVAQFLTVTVDLEQRRH------LEEQLKEIHRKLQAVDSGLIALRETSKHLEH 685
S LK Q L V ++ + ++++ ++ RKL+ + + L+E E
Sbjct: 479 ESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
Query: 686 KDNELRQKKKEL-LERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINV 744
+L +++ + E++T K +L++ L + +E+ E EERK I E +
Sbjct: 539 ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ----EAEERKLLRIIAEADG 594
Query: 745 QKAKLVTELTNLIK---ICTSLHIQKVD--LILQNTTVISEK--NKLESDYMAASSQLRL 797
++ + EL +I I S +++ D +L I + NK ES Y +R+
Sbjct: 595 ERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRI 654
Query: 798 TE--------------QHFIELDENRQRLLQKCKELMK 821
+ ++E RQ +EL+K
Sbjct: 655 LRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLK 692
Score = 61.2 bits (147), Expect = 5e-09
Identities = 136/645 (21%), Positives = 264/645 (40%), Gaps = 100/645 (15%)
Query: 151 INKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPP-EMH 209
++ + T K +++ V ++ L Q L + K+ ++E + + E H
Sbjct: 232 MDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQH 291
Query: 210 KYHCELKNLREKEKQLETSCKEKT---------------EYLQKMVQRNERYKQDVERFY 254
CE + ++K LE KE+ E + K + E K +VE+
Sbjct: 292 SLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHK 351
Query: 255 ERKRH--LDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEE 312
E ++ + L +EA + E + R+ +E+ RD + + + K T ++
Sbjct: 352 ETLKNQIVGLEREVEASKKQAELD--RKAMDELLRERDILNKNMLKAVNATQKQTDLVKL 409
Query: 313 MENERHNLEARIKEKATDIKEASQKCKQKQDVIER-KDKHIEE---LQQALIVKQNEELD 368
E + NLE I+ + K+ +QK ++ +E+ +D++I + L Q +++ +
Sbjct: 410 HEQAKRNLEGEIQ----NYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKV 465
Query: 369 RQRRIGNTRKMIEDLQNELKTTENC------------ENLQPQIDAITNDLRRIQ----- 411
R+ +I + RK I + + +LK +N +NL D IT+ R+++
Sbjct: 466 RETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQ 525
Query: 412 ----------DEKALCEGEIIDKR--RERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQR 459
E AL + + +R +E+ETL+ E + + + + + ++E + R+
Sbjct: 526 VDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKL 585
Query: 460 FRDTYDAVLWLRNNRDKFKQRVCEPIML---TINMKDNKNAKYIENHIPSNDLRAFVFES 516
R +A + + Q + E +L + D Y + I + L ES
Sbjct: 586 LRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKG--ES 643
Query: 517 Q-----EDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFD 571
Q EDM + E+ KKLR I +S ++ EL+Q FF REL
Sbjct: 644 QYNQRLEDMRILRLEI---KKLRREKGILARSM-------ANVEELRQE-FFHMQREL-- 690
Query: 572 APDPVMSYLCCQYHIHEV--PVGTEKTR--ERIERVIQETRLKQIYTAEEKYVVKTSFYS 627
+ C+ E+ P+ + R E + E +++I+T +++ + KT
Sbjct: 691 ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYEL-IQKIHTLQKRLISKTEEVV 745
Query: 628 NKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHR-------KLQAVDSGL----IAL 676
K + K+ L + + EQLK R +L+ + S L +
Sbjct: 746 EKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQS 805
Query: 677 RETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLM 721
+E +E NEL+ KK+ L +K K++ + K ++ + + LM
Sbjct: 806 KEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPMDNTFLM 850
Score = 52.0 bits (123), Expect = 3e-06
Identities = 127/681 (18%), Positives = 275/681 (40%), Gaps = 95/681 (13%)
Query: 186 EFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQR--- 242
EF K K+E E+ + ++ + + + K L+ ++ E LQK+ Q+
Sbjct: 214 EFRKKEKLE-----------KELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
Query: 243 ----NERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRK 298
NER +++E+F +M AK ++QE E+ LV +++ +E ++
Sbjct: 263 QKILNERAAKELEQF----------QMRNAK--------LQQENEQHSLVCEQLSQENQQ 304
Query: 299 LKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQA 358
++ E E H + I + ++ +K +D ++H E L+
Sbjct: 305 -------KALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQ 357
Query: 359 LIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCENLQPQIDAI--TNDLRRIQDE-KA 415
++ + E +++ RK +++L E +N+ ++A DL ++ ++ K
Sbjct: 358 IVGLEREVEASKKQAELDRKAMDELLRERDILN--KNMLKAVNATQKQTDLVKLHEQAKR 415
Query: 416 LCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRD 475
EGEI + ++ +K++K + D +NQ D L Q+ + +
Sbjct: 416 NLEGEI---QNYKDEAQKQRKIIFHLEKERDRYINQASD-LTQKVLMNMEDIKVRETQIF 471
Query: 476 KFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRV 535
+++++ E I +K +N Y N + E+Q++ + +++ K+ +
Sbjct: 472 DYRKKIAES---EIKLKQQQNL-YEAVRSDRNLYSKNLVEAQDE----ITDMKRKLKIMI 523
Query: 536 NAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEK 595
+ V K + K + L+Q L + H E E+
Sbjct: 524 HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
Query: 596 TRERI------ERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDL 649
RI ER+ Q+ L Q+ + + + ++++ +K+ Q + +
Sbjct: 584 KLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGES 643
Query: 650 EQRRHLEE-QLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLE 708
+ + LE+ ++ + K + G++A + ++E E ++ELL+ +T+ R LE
Sbjct: 644 QYNQRLEDMRILRLEIKKLRREKGILA--RSMANVEELRQEFFHMQRELLKERTRCRALE 701
Query: 709 QKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKV 768
+++ + L + + LE + A I++I+ + +L I K
Sbjct: 702 EELENPLNVHRWRK-----LEASDPNAYELIQKIHTLQKRL---------------ISKT 741
Query: 769 DLILQNTTVISEKNKLESDYMAASSQL-RLTEQHFIELDENRQRLLQKCKELMKRARQVC 827
+ +++ ++ EK KL YM L R E + +R L K+ +K
Sbjct: 742 EEVVEKELLLQEKEKL---YMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSEL 798
Query: 828 NLGAEQTLPQEYQTQVPTIPN 848
N+ Q+ +EY+ +V + N
Sbjct: 799 NMYEVQS--KEYKYEVEKLTN 817
Score = 43.1 bits (100), Expect = 0.001
Identities = 135/747 (18%), Positives = 291/747 (38%), Gaps = 110/747 (14%)
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEML 266
E + H +K + EK+L C+E ++V + + ++ + + + ++
Sbjct: 42 EYERLHAVMKKSYDNEKRLMAKCRELNA---EIVVNSAKVATALKLSQDDQTTIASLKK- 97
Query: 267 EAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEE---MENERH-NLEA 322
E ++ W + V Y++ + KE + LKE + +T +E+ + ++H N+
Sbjct: 98 EIEKAW---KMVDSAYDK----EQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRD 150
Query: 323 RIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIED 382
++ K KE Q + V++ ++ + +Q ++++E + + I ++ I+
Sbjct: 151 LLRFKEEVTKERDQLLSE---VVKLRESLAQTTEQQQETERSKE-EAEHAISQFQQEIQQ 206
Query: 383 LQNEL-KTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDH 441
QNE + E L+ ++ I D+ Q E + + + E + LE++ K
Sbjct: 207 RQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE---- 262
Query: 442 IVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNK-NAKYI 500
++N++ K ++F+ +A L N + VCE + K + AK
Sbjct: 263 ----QKILNERAAKELEQFQ-MRNAKLQQENEQHSL---VCEQLSQENQQKALELKAKEE 314
Query: 501 ENHIPS------NDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSL 554
E H N +R + + E EV +K+ N ++ + + S+
Sbjct: 315 EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLER---EVEASKKQ 371
Query: 555 NELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYT 614
EL + LRE ++ + ++ E+ + +E IQ Y
Sbjct: 372 AELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQN------YK 425
Query: 615 AEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLI 674
E + K F+ K E+ R++ + + L ++ I
Sbjct: 426 DEAQKQRKIIFHLEK--------------------ERDRYINQASDLTQKVLMNMED--I 463
Query: 675 ALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERK 734
+RET ++ +K++ E + K +Q + + L ++ ++E
Sbjct: 464 KVRET---------QIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITD 514
Query: 735 ASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQ 794
K+K + Q +L +++ LH+++ + + T+ +E KL Q
Sbjct: 515 MKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLR--------Q 566
Query: 795 LRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSL 854
L +HFIE E +R K R + E+ ++ QV S
Sbjct: 567 QALETKHFIEKQEAEER---------KLLRIIAEADGERLRQKKELDQV-------ISER 610
Query: 855 PMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVE- 913
++ L DE+ L + + + S LN +Y +R E++ L E+K + E
Sbjct: 611 DILGSQLVRRNDELALLYEKIKIQQSV---LNKG-ESQYNQRLEDMRILRLEIKKLRREK 666
Query: 914 --LDQYRENISQVKERWLNPLKELVEK 938
L + N+ ++++ + + +EL+++
Sbjct: 667 GILARSMANVEELRQEFFHMQRELLKE 693
Score = 38.5 bits (88), Expect = 0.035
Identities = 78/345 (22%), Positives = 136/345 (39%), Gaps = 44/345 (12%)
Query: 656 EEQLKEIHRKLQAVDSGLIALRETSK-HLEHKDNELRQKKKELLERK--TKKRQLEQKI- 711
E +E+ R Q V L + K +E++ KK E++ K R+L +I
Sbjct: 13 ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
Query: 712 --SSKLGS-LKLMEQDT---CNLEEEERKA----------STKIKEINVQKAKLVTELTN 755
S+K+ + LKL + D +L++E KA K KE + + + LT
Sbjct: 73 VNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTK 132
Query: 756 LIKICTSL----HIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELD----- 806
L++ + L H DL+ V E+++L S+ + L T + E +
Sbjct: 133 LVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEE 192
Query: 807 ----------ENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPM 856
E +QR + +E K+ + L Q QT++ + S
Sbjct: 193 AEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEE 252
Query: 857 VFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQ 916
+ Q L L E L F N + QE + EQL++E + K +EL
Sbjct: 253 L-QKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKA 311
Query: 917 YRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTE 961
E + Q++ + L ++ E+I++K + + EV+ H E
Sbjct: 312 KEEEVHQMRLD-IGKLNKIREQIHKKLHH---TEDQKAEVEQHKE 352
Score = 37.7 bits (86), Expect = 0.060
Identities = 53/323 (16%), Positives = 127/323 (39%), Gaps = 40/323 (12%)
Query: 628 NKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKD 687
++++S L+ + T E R EE I + Q + + E +
Sbjct: 163 DQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLE 222
Query: 688 NELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKA 747
EL+Q + ++ R+T+ + L+Q + L+ +EQ + +A+ ++++ ++ A
Sbjct: 223 KELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNA 282
Query: 748 KLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDE 807
KL E +C L + L+ E +++ D + +++R + E
Sbjct: 283 KLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLD-IGKLNKIREQIHKKLHHTE 341
Query: 808 NRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDE 867
+++ +++ KE +K Q+ L E ++ E
Sbjct: 342 DQKAEVEQHKETLK--NQIVGLEREVEASKKQA--------------------------E 373
Query: 868 IDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELK-GKKVELDQYRE------- 919
+D +E R N T+++ ++ +L E+ K + E+ Y++
Sbjct: 374 LDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
Query: 920 ---NISQVKERWLNPLKELVEKI 939
++ + ++R++N +L +K+
Sbjct: 434 IIFHLEKERDRYINQASDLTQKV 456
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 73.9 bits (180), Expect = 8e-13
Identities = 154/780 (19%), Positives = 317/780 (40%), Gaps = 167/780 (21%)
Query: 281 EYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQ 340
++E + + + +V L+ Q + +E + NLEA + + ++EA K +Q
Sbjct: 258 KFESIHFELTQSRAKVSMLESAQ-QQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQ 316
Query: 341 KQDVIERKDKHIEELQQALI---------VKQNEELDRQRR--IGNTRKMIEDLQN-ELK 388
Q ++ K++ ++E ++ I KQ + +RQR + N ++ + Q + K
Sbjct: 317 SQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKK 376
Query: 389 TTENCENLQPQIDAITNDL-------RRIQDEKALCEGEI-IDKRRERETLE-----KEK 435
E E +Q + + + +L +R+Q+ L + E+ I K + R+ E KEK
Sbjct: 377 VAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEK 436
Query: 436 KSV---------------DDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR 480
+ I++ ++ + K++ LR +F L N + K R
Sbjct: 437 LRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFS--------LMNENRELKVR 488
Query: 481 V---------CEPIMLTINMKDNKNAKYIENHIPSNDLRAF----------VFESQEDM- 520
V C+ + + ++ K I +L F F ++ED
Sbjct: 489 VAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRC 548
Query: 521 -------EVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAP 573
++ + E+R ++ + ++ S+SL S L L P
Sbjct: 549 IGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEP 608
Query: 574 DPVMSYLCCQ----YHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSF---- 625
+ + + + H + EK R+R+ I+E R K I E +K +
Sbjct: 609 VKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRT 668
Query: 626 --------------YSNKVISSNTSLKVAQFLTVTVDLEQR-----------RHLEEQLK 660
++ + S + K +Q LT+ LE++ LE++L
Sbjct: 669 SQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELM 728
Query: 661 EIHRKLQAVDSGL--------IALRETSK-HLE-HKDNELRQKKKELLERKTKKRQLEQK 710
E + K++++++ + +A + K HLE HK+ E K+ E LE + +K+ +Q+
Sbjct: 729 EKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEME---KQIERLEAQLEKK--DQQ 783
Query: 711 ISSKLGSLKLMEQDTC----NLEEEER---KASTKIKEINVQKAKLVTELTNLI------ 757
+ ++ +++QD +LE +R ++ ++K+ N++K + + L N +
Sbjct: 784 FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIK 843
Query: 758 --KICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQK 815
++ ++L I K +L+L + K K E S ++ ++ + + LQ+
Sbjct: 844 VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL----KIKNHSLQE 899
Query: 816 CKELMKRARQVCNLGAEQTLPQEYQ-TQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTE 874
E N+ + TL Q+ Q Q TI NG +D L++ + L +
Sbjct: 900 TSEQ--------NVILQHTLQQQQQMLQQETIRNGE-------LEDTQTKLEKQVSKLEQ 944
Query: 875 E--RSRASCFTGLN------PTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKE 926
E + R S L + E + +++ +LT + K+E+DQY+E +S++++
Sbjct: 945 ELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
Score = 71.6 bits (174), Expect = 4e-12
Identities = 163/809 (20%), Positives = 324/809 (40%), Gaps = 107/809 (13%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERY---KQDVERFYERKRHLD-LIEM 265
K EL+N E + + E E ++ +NER +Q++E R L+ +I
Sbjct: 460 KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQ 519
Query: 266 LEAKRPWVEYENVRQEYEEVKLVRDRVKE----EVRKLKEGQIPVTCRIEEMENER--HN 319
L KR +++ +Y+ + E KL ++ + I+E E ++ N
Sbjct: 520 LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN 579
Query: 320 LEARIKEKA----TDIKEASQKCKQKQDVIERKDKHIEEL---QQALIVKQNEELDRQRR 372
L A ++ D +E+S+ + + ++ + E Q + + E +RQR
Sbjct: 580 LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639
Query: 373 IGNTRKM------IEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRR 426
+ ++ IE ++LK N + Q I +L + E E+ K
Sbjct: 640 VTGIEELRTKLIQIEAENSDLKV--NMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCS 697
Query: 427 ERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVC---- 482
+ TLEK+ +++ IV + ++ K +L Q + + + L N + +++C
Sbjct: 698 QLLTLEKQ---LEEKIVAYSSIA-AKNAELEQELMEKNEKIRSLETNINTEHEKICLAFE 753
Query: 483 --EPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIA 540
+ I L + + K + +E + D + F+ QE L++ K+ + ++
Sbjct: 754 KAKKIHLEQHKEMEKQIERLEAQLEKKDQQ---FKEQEKTMSMLQQDIICKQHHLESL-- 808
Query: 541 PKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERI 600
D+ + S E+K+ D + L Q + E + + +
Sbjct: 809 ------DRLLTESKGEMKKENM---------KKDEALKAL--QNQVSEETIKVRQLDSAL 851
Query: 601 ERVIQET--RLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQ 658
E +E L Q+ +EK+ + S +V LK+ ++ EQ L+
Sbjct: 852 EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNH-SLQETSEQNVILQHT 910
Query: 659 LKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK-RQLEQKISSKLGS 717
L++ + LQ L +T LE + ++L Q+ ++ E +K R++E+K S
Sbjct: 911 LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 970
Query: 718 LKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTS--LHIQKVDLILQNT 775
L Q L R+ ++ + + +K+ E+ +L + + +H+ ++D+IL T
Sbjct: 971 ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQT 1030
Query: 776 TVISEKNK---LESDYMAASSQLRLTE--QHFIELDENRQRLLQKCKELMKRARQVCNL- 829
EK E + + S++ LTE Q L+ Q + K +++ +++ ++
Sbjct: 1031 KTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL 1090
Query: 830 -GAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEE----RSRASCFTG 884
A+ +L ++Y T M +D L E+D L E + RA+ T
Sbjct: 1091 QKAQLSLEEKYTTIKDL--TAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTH 1148
Query: 885 LNPTIVQEYTKREE---------------------EIEQLTEELKGKKVELD-------Q 916
L+ TI + + E+ +IE L ++L+ K +L Q
Sbjct: 1149 LDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQ 1208
Query: 917 YRENISQVK---ERWLNPLKELVEKINEK 942
+ ISQ+K ER +KE+ + E+
Sbjct: 1209 NEQEISQLKKEIERTQQRMKEMESVMKEQ 1237
Score = 68.9 bits (167), Expect = 2e-11
Identities = 150/805 (18%), Positives = 339/805 (42%), Gaps = 116/805 (14%)
Query: 156 TTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKS---IGPPEMHKYH 212
T +K +EEK+ A + + L Q+ + + K+ +E TE + + K H
Sbjct: 701 TLEKQLEEKIVAYSSIAAKNAE-LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIH 759
Query: 213 CELKNLREKE-KQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIE-MLEAKR 270
E EK+ ++LE ++K + ++ + +QD+ ++ HL+ ++ +L +
Sbjct: 760 LEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDI---ICKQHHLESLDRLLTESK 816
Query: 271 PWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATD 330
++ EN++++ E +K ++++V EE K+++ + EE+ + LE ++
Sbjct: 817 GEMKKENMKKD-EALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQ 875
Query: 331 IKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQN-ELKT 389
+K+ S++ Q ++ K+ ++E + ++ Q+ +Q+ + E ++N EL+
Sbjct: 876 LKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ-----ETIRNGELED 930
Query: 390 TENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLM 449
T+ L+ Q+ + +L++ ++ A +K R+ E EK H
Sbjct: 931 TQT--KLEKQVSKLEQELQKQRESSA-------EKLRKME----EKCESAAH-------- 969
Query: 450 NQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDL 509
+ D RQ+ + ++ D++K+ + + +++K + K + H+ D+
Sbjct: 970 --EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAM--HLSQLDM 1025
Query: 510 RAFVFESQEDMEVFLKEVRDNKKLRVNAVIA-----PKSSYADKAPSRSLNELKQYGFFS 564
+ +++ ++E V++ +KL+ + K + + ELK S
Sbjct: 1026 --ILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK-----S 1078
Query: 565 YLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTS 624
LR+L + D + + + E+ I+ + E R ++ ++K +
Sbjct: 1079 TLRQLQELRDV----------LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEM 1128
Query: 625 FYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLE 684
+ K N LK +D+ R H E ++I + ++ + L+E +K +E
Sbjct: 1129 DQALK--ERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIE 1186
Query: 685 HKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLE----EEERKASTKIK 740
+++L+ K++L E++ Q EQ+IS ++ +Q +E E+E+ +T+ K
Sbjct: 1187 SLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYK 1246
Query: 741 EINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQ 800
E L EL + + H + + Q E +L S+ + +
Sbjct: 1247 E----AIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDA 1302
Query: 801 HFIELDENRQRLLQKCKELMKRAR---QVCNLGAE-QTLPQEYQTQVPTIPNGHNSSLPM 856
H L E + K +E AR ++ L AE ++L + Y ++ I + N +
Sbjct: 1303 HGNHLAE--ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEM--ISHQENHAKWK 1358
Query: 857 VFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQ 916
+ D ++ ++QL E+L+ K+EL++
Sbjct: 1359 ISAD----------------------------------SQKSSVQQLNEQLEKAKLELEE 1384
Query: 917 YRENISQVKERWLNPLKELVEKINE 941
++ +S + ++ + E++E NE
Sbjct: 1385 AQDTVSNLHQQ-VQDRNEVIEAANE 1408
Score = 37.0 bits (84), Expect = 0.10
Identities = 69/360 (19%), Positives = 150/360 (41%), Gaps = 47/360 (13%)
Query: 605 QETRLKQIYTAEEKYVVKTSF--YSNKVISSNTSLKVAQFL---TVTVDLEQRRHLEEQL 659
+ R + +Y AEE + +F Y KV ++ + + +T ++ + L+E+
Sbjct: 353 ERQRNEALYNAEE---LSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERC 409
Query: 660 KEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLK 719
+L+ + L L+E + + + K + K E++ + T+ RQ K+ S+L +
Sbjct: 410 GLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKD 469
Query: 720 LMEQDTCNLEEEERKASTKIKEIN---------VQKAKLVTELTNLIKICTSLHIQKVDL 770
+ +D +L E R+ ++ N ++ +++ EL +L KI + L +++
Sbjct: 470 EILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRV--ELRSLEKIISQLPLKR--- 524
Query: 771 ILQNTTVISEKNKLESDYMAASSQ-----LRLTEQHFIELDENRQRLLQKCKELMKRARQ 825
+ K+ L M++ S + E + + + E R +L K E+ K
Sbjct: 525 -----ELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQK---- 575
Query: 826 VCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGL 885
L A T Q Q+ + + +S L ++L+ L + S
Sbjct: 576 ---LHANLTANQLSQSLITCNDSQESSKL--------SSLETEPVKLGGHQVAESVKDQN 624
Query: 886 NPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSN 945
T+ ++Y K + + EEL+ K ++++ ++ + + + E++ EK SN
Sbjct: 625 QHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASN 684
Score = 35.0 bits (79), Expect = 0.39
Identities = 59/296 (19%), Positives = 123/296 (41%), Gaps = 40/296 (13%)
Query: 721 MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQ------KVDLI--- 771
M + +++E + K+ ++ Q A LVT+ +L+ S+H + KV ++
Sbjct: 220 MFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESA 279
Query: 772 ---LQNTTVISEK-NKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVC 827
+ ++ E+ LE++ A LR E +L+++++ +++K + L + +
Sbjct: 280 QQQAASVPILEEQIINLEAEVSAQDKVLREAEN---KLEQSQKMVIEKEQSLQESKEECI 336
Query: 828 NLGA---EQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTL-DEIDALLTEERSRASCFT 883
L EQT + + + L FQ + ++++ + EE
Sbjct: 337 KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEE------- 389
Query: 884 GLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLN---PLKELVEKIN 940
+ + T E+E ++L E K EL+ +E + Q+KE N L+ + K +
Sbjct: 390 ----ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNS 445
Query: 941 EKFSNFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGER 996
E + S Q +++ EN+++ +R KF + EL + ER
Sbjct: 446 EVMAQLTESRQSILKLESELENKDEI------LRDKFSLMNENRELKVRVAAQNER 495
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 73.6 bits (179), Expect = 1e-12
Identities = 191/1017 (18%), Positives = 409/1017 (40%), Gaps = 168/1017 (16%)
Query: 141 DVAKNQSFW---FINKKSTTQKIVEEKVAALN-----------IQVGNLCQFLPQDKVGE 186
+VAK W F++ ++ +I EK + + +Q LC L +D +
Sbjct: 1885 NVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC--LEKDNENK 1942
Query: 187 FAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEK---QLETSCKEKTEYLQKMVQRN 243
K+ + E S+ E ++ EL + +K QL KEKT+ L+
Sbjct: 1943 ----QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSEC 1998
Query: 244 ERYKQDVERFYERKRHL------DLIEMLEAKRPWVE-YENVRQEYEEVKLVRDRVKEEV 296
Q E + K L D+ E+L+ K E +++ ++ + + L + ++ ++
Sbjct: 1999 LHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQI 2058
Query: 297 RKL-KEGQIPVT------CRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKD 349
+L KE ++ V R+ E + E+ N+ ++ + E + + Q+ + +
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118
Query: 350 KHIEELQQALIVKQNEEL-------DRQRRIGNTRKMIEDLQNELKTTE--------NCE 394
+ IE+L+ + + ++L +R+R + + +E+L+ EL+ +E + E
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE 2178
Query: 395 NLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKED 454
N + +++ + + + + E +++ R E+E L K+ + + D L++ +
Sbjct: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKS 2238
Query: 455 KLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPS-NDLRAFV 513
L ++ E + I + + ++N + N+ A +
Sbjct: 2239 LLEEK-----------------------EQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Query: 514 FESQEDMEVFLKE----VRDNKKLRVNAVIAPKSSYADKAPSR-SLNELKQYGFFSYLRE 568
QE M+ + + + +LR N++ +K +R +E KQ L+E
Sbjct: 2276 CGDQEIMKATEQSLDPPIEEEHQLR-NSI--------EKLRARLEADEKKQLCVLQQLKE 2326
Query: 569 LFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVK--TSFY 626
D + + E +ER ++ R Q + A E K
Sbjct: 2327 SEHHADLLKGRV-----------------ENLERELEIARTNQEHAALEAENSKGEVETL 2369
Query: 627 SNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHR--KLQAVDSGLIALRETSKHLE 684
K+ SL+ + VT+ E+ E KE R +L+ ++S
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF----------- 2418
Query: 685 HKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLM------EQDTCNLEEEERKASTK 738
+N L++K++E ++ K K + + ++L L +Q+ C +E+ S++
Sbjct: 2419 --ENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN--LSSQ 2474
Query: 739 IKEINVQKAKLVTEL----TNLIKICTSLH--IQKVD-----LILQNTTVISEKNKLESD 787
++ + ++KA+L+ L N I + +S++ IQ+V+ L ++ + KN+++
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534
Query: 788 YMAASSQLRLTEQHFIELDENRQ-RLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTI 846
S ++ +H + ++N + R L E + Q N + TL + Q+ +
Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTL-EVLQSSYKNL 2593
Query: 847 PNGHNSSLPMVFQDLPNTLDEIDALLTEE-------RSRASCFTGLNPTIVQEYTKREEE 899
N L + D + +++++ + +E A L + E + E
Sbjct: 2594 EN----ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 900 IEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVE---KINEKFSNFFSSMQCAGE- 955
++ L EE+K K +L + S++K+ K+ VE K+ E+ + + + A +
Sbjct: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK 2709
Query: 956 -----VDLHTENEEDYDKYGIRIRVKFRS-STQLHELTPHHQSGGERSVSTMLYLMALQE 1009
+D + + E + Y ++ K S+Q E+ S E + S L+E
Sbjct: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEE 2769
Query: 1010 LNRCPFRVVDEINQGMDPINERRVFEM-VVNTACKENTSQYFFITPKLLQNLPYSEK 1065
L + + +NQ + NER +M ++ +CK+ + + +L Q EK
Sbjct: 2770 LKKTKMDNLKYVNQ-LKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
Score = 68.2 bits (165), Expect = 4e-11
Identities = 154/781 (19%), Positives = 308/781 (39%), Gaps = 101/781 (12%)
Query: 217 NLREKEKQLETSCKEKTEYLQKMVQRNER-YKQDVERFYERKRHLDL--IEMLEAKRPWV 273
+L ++ K + K L+ +Q +E+ K V +F E + L+ +E++E ++
Sbjct: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337
Query: 274 ----EYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKAT 329
E +Y++ ++++++KL E ++C+ + E+ R +LE +IKEK
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTED---LSCQRQNAESARCSLEQKIKEKEK 394
Query: 330 DIKEASQKCKQK-----QDVIERKDKHIEELQQALIVKQ--NEELDRQRRI-GNTRKMIE 381
+ +E + ++ Q+ I+ K + +ELQQA + ELD+ + +E
Sbjct: 395 EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE 454
Query: 382 DLQNELKTTENC-ENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDD 440
+ + +L E + Q + + + + ++ E L + K RE LE E K++
Sbjct: 455 EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQ 514
Query: 441 HIVRFDNL---MNQKEDKLRQRFRDTYDAVLWLRNN----------RDKFKQRVCEPIML 487
+ + N M K RD + + N+ D KQR C +L
Sbjct: 515 CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLL 574
Query: 488 --------TINMKDNKNAKYIENHIPSNDLRAFVFES-QEDMEVFLKEVRDNKKLRVNAV 538
+N K +K K + + + +L+ +E +E+ +F +N+KL + +
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKL-LTQM 633
Query: 539 IAPKSSYADK----APSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTE 594
+ K + K ++K + + +R L + + V
Sbjct: 634 ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL-------------EMDRENLSVEIR 680
Query: 595 KTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQR-R 653
++ E +++ E + + S ++ N LK +Q DLE + +
Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740
Query: 654 HLEEQLKEIHRKLQAVDSGLIALRE--TSKHLEHKDNELRQKKKELLERKTKKRQLEQKI 711
L ++ + R Q + + +LR+ SK NE Q+ +++ I
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
Query: 712 SSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLI 771
+ GS+ E+ C LE ++ ++ I + V + E S DL
Sbjct: 801 IGEQGSMP-SERSECRLEADQSPKNSAILQNRVDSLEFSLE---------SQKQMNSDLQ 850
Query: 772 LQNTTVISEKNKLESDYMAA----SSQLRLTEQHFIELDE----NRQRLLQKCKELMKRA 823
Q ++ K ++E + M A S + T Q +L E ++ + + L +
Sbjct: 851 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 824 RQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFT 883
+++ Q L + +T+ I S+ + +D L + L+ E+ S
Sbjct: 911 KEL------QLLNDKVETEQAEIQELKKSN--HLLEDSLKELQLLSETLSLEKKEMSSII 962
Query: 884 GLNPTIVQEYTKREEEIEQLTEE---LKGKKVELDQYRENISQVKERWLNPLKELVEKIN 940
LN + EIE+LT+E LK L+Q + N+ Q E + N + E + I+
Sbjct: 963 SLN----------KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012
Query: 941 E 941
E
Sbjct: 1013 E 1013
Score = 65.5 bits (158), Expect = 3e-10
Identities = 173/943 (18%), Positives = 364/943 (38%), Gaps = 163/943 (17%)
Query: 213 CELKN-LREKEKQLETSCKEKTEYLQKM----VQRNERYKQDVERFYERKRHL--DLIEM 265
C L+ ++EKEK+ + + Q + +Q R Q++++ L +L ++
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 266 LEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIK 325
K+ + EN +E+++ KL R + ++KE ++ + +EEM+ E + L++ +
Sbjct: 443 TSVKQ---QLENNLEEFKQ-KLCRAEQAFQASQIKENELRRS--MEEMKKENNLLKSHSE 496
Query: 326 EKA-------TDIKEASQKCKQKQDVIER-------KDKHIEELQQALIVKQNE------ 365
+KA ++K Q Q Q+ E ++ + +LQ+ + ++N
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556
Query: 366 -----ELDRQR-----RIGNTRKMIEDLQNEL-KTTENCENLQPQIDAITNDLRRIQDEK 414
+L++QR + IE L ++L KT + + L ++ + +++EK
Sbjct: 557 KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEK 616
Query: 415 ALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKE-------DKLRQRFRDTYDAV 467
L + + +E EK+++ I + + ++ +++R D +
Sbjct: 617 TLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLS 676
Query: 468 LWLRNNRDKFKQRVCE---------PIMLTINMKDNKNAKYIENH-IPSNDLRAFVFESQ 517
+ +RN + + E + D K+ K IEN + ++ L V + +
Sbjct: 677 VEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
Query: 518 EDMEVFLKEVRDNKKLRVNAVIAPKSSYAD----KAPSRSLNELKQYGFFSYLRELFDAP 573
+++ E+ D + + A S D K S NE Q ++ ++
Sbjct: 737 HKLQLLSNEIMDKDRC-YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ----- 790
Query: 574 DPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISS 633
P M + + + +E++ R+E ++ ++ S S K ++S
Sbjct: 791 -PAMHHSFANIIGEQGSMPSERSECRLE--ADQSPKNSAILQNRVDSLEFSLESQKQMNS 847
Query: 634 NTSLKVAQFLTVTVDLEQRRHLEEQL---------KEIHRKLQAVDSGLIALRETSKHLE 684
+ + + + + ++E+ EQ+ + I + + + + ET LE
Sbjct: 848 DLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALE 907
Query: 685 HKDNELRQKKKELLERKTKKRQLEQK---ISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
+K+ EL+ ++ + + ++L++ + L L+L+ +T +LE++E + + +
Sbjct: 908 NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL-SETLSLEKKEMSSIISLNK 966
Query: 742 INVQKAKLVTELTNLIKICTSLHIQKVDLILQN---TTVISEKNK--------------- 783
++ +L E L +I SL+ +K++LI ++ I E+ K
Sbjct: 967 REIE--ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLI 1024
Query: 784 --------------LESDYMAA---SSQLRLTEQHFIELDENRQRLLQKCKELMKRARQV 826
L Y AA +S+L L ENR+ L++ KE + Q
Sbjct: 1025 LLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE 1084
Query: 827 C------------NLGAE-QTLPQEYQTQVPTIPNGHNSSLPMVFQDL------------ 861
NL E +T+ Q ++++ N S + Q++
Sbjct: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144
Query: 862 --PNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLT----EELKGKKVELD 915
+ L E + L+ +++ C + I +RE E Q +L+ K++ LD
Sbjct: 1145 EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLD 1204
Query: 916 QYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGI---- 971
Y + Q++ N +L E EK G DL T N +D I
Sbjct: 1205 SYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG--DLETSNLQDMQSQEISGLK 1262
Query: 972 --RIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNR 1012
I + + + HEL+ S + L EL +
Sbjct: 1263 DCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEK 1305
Score = 58.2 bits (139), Expect = 4e-08
Identities = 127/690 (18%), Positives = 284/690 (41%), Gaps = 88/690 (12%)
Query: 153 KKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPP--EMHK 210
+ T ++++ ++ LN V LC E+++ATE+S+ PP E H+
Sbjct: 2253 ESKTAVEMLQNQLKELNEAVAALC--------------GDQEIMKATEQSLDPPIEEEHQ 2298
Query: 211 YHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKR 270
++ LR + LE K++ LQ++ E + H DL++
Sbjct: 2299 LRNSIEKLRAR---LEADEKKQLCVLQQLK--------------ESEHHADLLKG----- 2336
Query: 271 PWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATD 330
EN+ +E E + ++ E K + +IE M LE + ++
Sbjct: 2337 ---RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 331 IKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTT 390
+ + + +++Q+ I + + L K+ E++ + + +M LQ +LK
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM---LQTQLK-- 2448
Query: 391 ENCENLQPQIDAITNDLRRIQDEKALCEGEI----IDKRRERETLEKEKKSVDDHIVRFD 446
L ++ A+ ND + ++ ++ ++K + + L++ K + +
Sbjct: 2449 ----ELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
Query: 447 NLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPS 506
L+ + ED +Q+ + + L+N +Q V + ++ + ++ + E ++
Sbjct: 2505 GLIQEVEDG-KQKLEKKDEEISRLKNQIQDQEQLVSK-----LSQVEGEHQLWKEQNL-- 2556
Query: 507 NDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYL 566
+LR E ++ ++V + N L+ + + +SSY + L ++ + F +
Sbjct: 2557 -ELRNLTVELEQKIQVLQSK---NASLQ-DTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611
Query: 567 RELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFY 626
++ + Q +HE+ T + +E + ++ RL + + +
Sbjct: 2612 NKMTAKETEL------QREMHEMAQKTAELQEELSG--EKNRLAGELQLLLEEIKSSKDQ 2663
Query: 627 SNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKL-QAVDSGLIALRETSKHLEH 685
++ N+ LK + +E+ + E++ E +L +A L +T+K E
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 686 KDNELRQK---KKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEI 742
+ R+K K+E L ++K +++ SSK ++ T LEE ++ +K +
Sbjct: 2724 EIQTYREKLTSKEECL--SSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYV 2781
Query: 743 NVQK---AKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTE 799
N K + ++ LIK C L +K L + + + + + K ++ + + LT
Sbjct: 2782 NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT- 2840
Query: 800 QHFIELDENRQRLLQKCKELMKRARQVCNL 829
E+ E ++ L +K KE + + C+L
Sbjct: 2841 ---TEIKELKETLEEKTKEADEYLDKYCSL 2867
Score = 56.6 bits (135), Expect = 1e-07
Identities = 150/781 (19%), Positives = 309/781 (39%), Gaps = 161/781 (20%)
Query: 313 MENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRR 372
+E + L R +K +++ K K+++ +++ ++ L+ AL KQ ++++ ++
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEK---QQRQFQLDSLEAAL-QKQKQKVENEKT 60
Query: 373 IGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLE 432
G K + + E CE+L+ I+++L+ + + EG++ +++ E LE
Sbjct: 61 EGTNLK-----RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLE 115
Query: 433 KEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMK 492
+E K + R Q+ + +++N
Sbjct: 116 QELKRCKSELER---------------------------------SQQAAQSADVSLNPC 142
Query: 493 DNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLR--VNAVIAPKSSYADKAP 550
+ + PS +E + E + KEV + K+L V A+ A K+S
Sbjct: 143 NTPQKIFTTPLTPSQYYSGSKYEDLK--EKYNKEVEERKRLEAEVKALQAKKASQTLPQA 200
Query: 551 SRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLK 610
+ + ++ ++ A V S+ EKT + Q T ++
Sbjct: 201 TMNHRDIARH----------QASSSVFSWQ------------QEKTPSHLSSNSQRTPIR 238
Query: 611 QIYTAEEKYVVKTSFYSNK--VISSNTSLKVAQ--FLTVTVDLEQRRHLEEQLK----EI 662
+ ++A S++S + V S ++L++ + + D HL +QLK E+
Sbjct: 239 RDFSA--------SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL 290
Query: 663 HRKLQAVDSGLIALRETSKHLEHKDNELR----QKKKELLERK----------------- 701
K+ ++ L + K +K EL+ + K EL+E++
Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350
Query: 702 ----TKKRQLEQKISSKLGSLKLMEQDT----CNLEEEERKASTKIKE-----------I 742
TK LEQK+ L Q+ C+LE++ ++ + +E +
Sbjct: 351 DQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTL 410
Query: 743 NVQKAKLVTELTNLIKICTSLH-IQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH 801
+ + ++ LT ++ ++H + + +L + S K +LE++ +L EQ
Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAEL----DKLTSVKQQLENNLEEFKQKLCRAEQA 466
Query: 802 F----IELDENRQRLLQKCKE--LMK-----RARQVCNLGAEQTLPQEYQTQVPTIPN-- 848
F I+ +E R+ + + KE L+K +AR+VC+L AE ++ Q
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 849 -GHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQE--YTKREEEIEQLTE 905
N+S + +DL +++ + LT E+ + + + KRE IEQL +
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLND 586
Query: 906 ELKGKKVE-------LDQYRENISQVKER------WLNPLKELVEKINEKFSNFFSSMQC 952
+L + E L+ ++ ++KE W + ++L+ ++ + N S +
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 953 AGEVDLHTENEEDYDKYGIRIRVKFRSSTQLH-ELTPHHQSGGERSVSTMLYLMALQELN 1011
E L T+ + ++ Y R+R L E+ H +SV +A EL
Sbjct: 647 L-ETCLKTQQIKSHE-YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQ 704
Query: 1012 R 1012
+
Sbjct: 705 Q 705
Score = 56.6 bits (135), Expect = 1e-07
Identities = 124/674 (18%), Positives = 257/674 (38%), Gaps = 94/674 (13%)
Query: 309 RIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELD 368
++E + NE L++++ + + + C + + ++ K +L + L + +
Sbjct: 1796 KVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQE 1855
Query: 369 RQRRIGNTRKMIEDLQ---NELKTTENCENLQPQIDA-------ITNDLRRIQDEKALCE 418
+R+ + + DL+ ++ + +N+ D+ + N+L RI+ EKA E
Sbjct: 1856 LLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE 1915
Query: 419 GEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDK-LRQRFRDTYDAVLWLRNNRDKF 477
E + + E ++ EK ++ DN QK L + LR D
Sbjct: 1916 HEALYLEADLEVVQTEKLCLEK-----DNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
Query: 478 KQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKL---- 533
++ L+ MK+ + +L + E ++V EV++ +L
Sbjct: 1971 SKKTTALDQLSEKMKEK-----------TQELESHQSECLHCIQVAEAEVKEKTELLQTL 2019
Query: 534 --RVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPV 591
V+ ++ K+ +K S + +S C+ +
Sbjct: 2020 SSDVSELLKDKTHLQEKLQS------------------LEKDSQALSLTKCELENQIAQL 2061
Query: 592 GTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQ 651
EK E +++E+ Q +E Y +K + + K L ++ E+
Sbjct: 2062 NKEK-----ELLVKESESLQARLSESDY---EKLNVSKALEAALVEKGEFALRLSSTQEE 2113
Query: 652 RRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKI 711
L ++++ +++A + + + E K E +++ L+ K E LER+ + + Q++
Sbjct: 2114 VHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD-KVENLERELQMSEENQEL 2172
Query: 712 SSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLI 771
E +T + EE S K+ E+++ L +E NL K I
Sbjct: 2173 VILDAENSKAEVETLKTQIEEMARSLKVFELDL--VTLRSEKENLTK-----------QI 2219
Query: 772 LQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQ-KCKELMKRARQVCNLG 830
+ +SE +KL S + + + E E + +LQ + KEL + +C G
Sbjct: 2220 QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC--G 2277
Query: 831 AEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIV 890
++ + Q+ P I H L N+++++ A L + + C ++
Sbjct: 2278 DQEIMKATEQSLDPPIEEEH---------QLRNSIEKLRARLEADEKKQLC-------VL 2321
Query: 891 QEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSM 950
Q+ + E + L ++ + EL+ R N N E VE + K S+
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE-VETLKAKIEGMTQSL 2380
Query: 951 QCAGEVDLHTENEE 964
+ E+D+ T E
Sbjct: 2381 R-GLELDVVTIRSE 2393
Score = 44.3 bits (103), Expect = 6e-04
Identities = 157/836 (18%), Positives = 342/836 (40%), Gaps = 153/836 (18%)
Query: 152 NKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKY 211
+K S T+K + ++AL + K E+ +L + + L + KS + +
Sbjct: 586 DKLSKTEKESKALLSALEL------------KKKEYEELKEEKTLFSCWKSENEKLLTQM 633
Query: 212 HCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRP 271
E +NL+ K LET K + + +R + D E R+L +L++K
Sbjct: 634 ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH--NVLDSKS- 690
Query: 272 WVEYENVRQEYEEVKLVRD----RVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEK 327
VE E + Y E++ + + ++E+ + +T ++E++E++ L I +K
Sbjct: 691 -VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDK 749
Query: 328 ATDIKEASQKCKQKQDVIERKDKHI---EELQQALIVKQNEELDRQRRIGNTRKMIEDLQ 384
++ + + +D+++ KD + E+ Q++L+ D+Q + ++ I Q
Sbjct: 750 DRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA-----FDQQPAMHHSFANIIGEQ 804
Query: 385 NEL------------KTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLE 432
+ ++ +N LQ ++D++ L + + D +++ E L
Sbjct: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNS-------DLQKQCEELV 857
Query: 433 KEKKSVDDHIVRFDNLMNQKEDKLRQRF-RDTYDAVLWLRNNRDKFKQRVCEPI------ 485
+ K ++++++ K +++ Q F +T + L+ + + V E +
Sbjct: 858 QIKGEIEENLM--------KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK 909
Query: 486 ---MLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPK 542
+ +N K I+ SN L + +S +++++ L E +K ++++I+
Sbjct: 910 EKELQLLNDKVETEQAEIQELKKSNHL---LEDSLKELQL-LSETLSLEKKEMSSIISLN 965
Query: 543 SSYAD---------KAPSRSLNE------LKQYGFFSYLRELFDAPDPVMSYLCCQYHIH 587
+ K + SLN+ K F +Y+ D + +S L QY
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI----DEREKSISELSDQYKQE 1021
Query: 588 EVPV--GTEKTRERIERVIQETRLKQIYTAEEKYVVK--TSFYSNKVISSNTSLKVA--- 640
++ + E+T E + Q+ + Q ++ + ++ TS N+ + LK A
Sbjct: 1022 KLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRK-NELEQLKEAFAK 1080
Query: 641 ---QFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKEL 697
+FLT E+R + + E+ QA+ S + + SK +E K+E+
Sbjct: 1081 EHQEFLTKLAFAEERN--QNLMLELETVQQALRSEMTDNQNNSK------SEAGGLKQEI 1132
Query: 698 LERKTKKRQLEQKISSKLGS----LKLM--EQDTCNLEEEERKASTKIKEINVQ----KA 747
+ K ++ +++++++ L +K+M + + NLE E + S K +E K
Sbjct: 1133 MTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKP 1192
Query: 748 KLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDE 807
++ E+ + + + +++ +L+N + ++++ E + + Q + L +
Sbjct: 1193 QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQD 1252
Query: 808 NRQRLLQKCKELMKRARQVCNLGAEQTL---PQEYQTQVPTIPNGHNSSLPMVFQDLPNT 864
+ + + K+ C + AE+ P E T N+ L Q N
Sbjct: 1253 MQSQEISGLKD--------CEIDAEEKYISGPHELSTS-----QNDNAHLQCSLQTTMNK 1299
Query: 865 LDEID-----------ALLTE-ERSRASCFTGLNPTIVQEYTKREEEIEQLTEELK 908
L+E++ L+TE SR+ C T K EE+ +L E+K
Sbjct: 1300 LNELEKICEILQAEKYELVTELNDSRSECITATR--------KMAEEVGKLLNEVK 1347
Score = 42.0 bits (97), Expect = 0.003
Identities = 122/692 (17%), Positives = 259/692 (37%), Gaps = 94/692 (13%)
Query: 280 QEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCK 339
Q+ +E++ D++K+E + + Q + ++ ++ +E K + T++K +Q+
Sbjct: 18 QKIQELEGQLDKLKKEKQ---QRQFQLDSLEAALQKQKQKVENE-KTEGTNLKRENQRL- 72
Query: 340 QKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELK----TTENCEN 395
++ E +K +++ L VK+++ ++ ++ + +K IE L+ ELK E +
Sbjct: 73 --MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
Query: 396 LQPQIDAITNDLRRIQD--EKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKE 453
D N Q L + + + EK K V+ + + E
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE------ERKRLEAE 184
Query: 454 DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIP-SNDLRAF 512
K Q + + N+RD + + + K + P D A
Sbjct: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
Query: 513 VFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDA 572
F ++++ L++ A S + + + L++LK LR +
Sbjct: 245 YFSGEQEV------TPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN--QELRNKINE 296
Query: 573 PDPVMSYLCCQYH----------IHEVPVGTEKTRERI---ERVIQETRLKQIYTAEEKY 619
+ L Q H E+ + EK + + E+V+ + R + + T +
Sbjct: 297 LE-----LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 620 VVKTSF----YSNKVISSNTSLKVAQFLTVTVDLEQR-----RHLEEQLKEIHRKLQAVD 670
T + K ++ + S + + LEQ+ + +E+L R Q +D
Sbjct: 352 QASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLD 411
Query: 671 SGLIALR-ETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSL----------K 719
I ++ ++ L+ N + EL + + K+QLE + L +
Sbjct: 412 QECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ 471
Query: 720 LMEQDTCNLEEEERKASTKIKEINVQKAK----LVTELTNLIKICTSLHIQKVDLILQNT 775
+ E + EE +K + +K + QKA+ L EL N+ + ++ +NT
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNT 531
Query: 776 TVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKE--LMKRARQVCNLGAEQ 833
+ + L+ + L L + D +QR C + L KR + L +
Sbjct: 532 SQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR---DCSQDLLKKREHHIEQLNDKL 588
Query: 834 TLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEY 893
+ ++ + +L + +E L EE++ SC+ N ++ +
Sbjct: 589 SKTEK-----------ESKALLSALELKKKEYEE----LKEEKTLFSCWKSENEKLLTQM 633
Query: 894 TKREE----EIEQLTEELKGKKVELDQYRENI 921
+E +I L LK ++++ +Y E +
Sbjct: 634 ESEKENLQSKINHLETCLKTQQIKSHEYNERV 665
Score = 40.0 bits (92), Expect = 0.012
Identities = 105/567 (18%), Positives = 212/567 (37%), Gaps = 96/567 (16%)
Query: 215 LKNLREKEKQLETSCKE----KTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKR 270
L++ ++ L+ C+E K E + +++ + ++ V +R L
Sbjct: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898
Query: 271 PWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATD 330
+ + +E++L+ D+V+ E I+E++ H LE +KE
Sbjct: 899 VAETLSALENKEKELQLLNDKVETE-----------QAEIQELKKSNHLLEDSLKELQLL 947
Query: 331 IKEASQKCKQKQDVIERKDKHIEELQQ--ALIVKQNEELDRQRR------------IGNT 376
+ S + K+ +I + IEEL Q + + N L++++ I
Sbjct: 948 SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007
Query: 377 RKMIEDL-----QNELKTTENCENLQPQIDAITNDLRRIQDEK-----------ALCEGE 420
K I +L Q +L + CE + ++ + Q++ +LCE
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067
Query: 421 IIDKRRERETLEKEKKSVDDHIV----RFDNLMNQKE---DKLRQRFRDTYDAVLWLRNN 473
+ + +E KE + + R NLM + E LR D N
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTD--------NQN 1119
Query: 474 RDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKE-VRDNKK 532
K + + ++T+ + NK K + + + N+ V +++ + + E +R++ K
Sbjct: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
Query: 533 LRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVG 592
R + + + + P L E+K+ SY +L + + + + E
Sbjct: 1180 ERES-----ERNQCNFKPQMDL-EVKEISLDSYNAQLVQLEAMLRNK---ELKLQE---- 1226
Query: 593 TEKTRERIERVIQ------ETRLKQIYTAEEKYVVKTSFY--SNKVISSNTSLKVAQFLT 644
+EK +E ++ +Q ET Q ++E +K K IS L +Q
Sbjct: 1227 SEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQ--- 1283
Query: 645 VTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKK 704
HL+ L+ KL ++ L+ L EL + E + T
Sbjct: 1284 -----NDNAHLQCSLQTTMNKLNELEKICEILQAEKYELV---TELNDSRSECI---TAT 1332
Query: 705 RQLEQKISSKLGSLKLMEQDTCNLEEE 731
R++ +++ L +K++ D+ L E
Sbjct: 1333 RKMAEEVGKLLNEVKILNDDSGLLHGE 1359
Score = 34.3 bits (77), Expect = 0.67
Identities = 84/431 (19%), Positives = 171/431 (39%), Gaps = 62/431 (14%)
Query: 590 PVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQ-------F 642
P G +KT+ E + ++ + +V F N+ N L+V +
Sbjct: 1733 PPGEDKTQGSSECI------SELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL 1786
Query: 643 LTVTVDLEQR-RHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERK 701
L V D +++ L ++KE+ KL + L+ E LE EL+++ +L E+
Sbjct: 1787 LHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK- 1845
Query: 702 TKKRQLEQKISSKLGSLKLMEQDTCNLEE-----EERKASTKIKEINVQKAKLVTELTNL 756
+E +C+ +E E + E++ K+ N+
Sbjct: 1846 -------------------LEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNV 1886
Query: 757 IKICTSLHIQKVDLILQNTTVISEKNKLESD--YMAASSQLRLTEQHFIELD-ENRQRLL 813
K+ S + +D+ + + + SEK +E + Y+ A ++ TE+ +E D EN+Q+++
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVI 1946
Query: 814 QKCKELMKRARQVCN-LGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALL 872
+E + N L E + T + + + L I
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006
Query: 873 TEERSRASCFTGLNPTI---VQEYTKREEEIEQL---TEELKGKKVELDQYRENISQVKE 926
E + + L+ + +++ T +E+++ L ++ L K EL+ +++ KE
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 927 RWLNPLKELVEKINE---KFSNFFSSMQCA----GEVDLH---TENEEDYDKYGI---RI 973
+ + L +++E + N +++ A GE L T+ E + GI R+
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV 2126
Query: 974 RVKFRSSTQLH 984
R++ QLH
Sbjct: 2127 RIEADEKKQLH 2137
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 72.8 bits (177), Expect = 2e-12
Identities = 156/803 (19%), Positives = 324/803 (40%), Gaps = 124/803 (15%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K EL LR+ +L EKT LQ+ E K++ E+ + + +++ EA+
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKLQQ----EEVQKKNAEQAATQLK----VQLQEAE 494
Query: 270 RPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKAT 329
R W E ++ +R R E + Q + + ENE +L +++ +
Sbjct: 495 RRWEEVQSY---------IRKRTAEH----EAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 330 DIKEASQKCKQKQDVIERKDKHIEELQQAL--IVKQNEELDRQRRIGNTR---------- 377
++ Q+ Q + +++ E LQ + I++QNE L Q + +++
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 378 -----KMIEDLQNELKTTENCENLQPQIDAITN---DLRRIQDEKALCEGEIIDKRRERE 429
K+I + ++K TE ++L + D +T+ +L+ IQ+ L + E+ ++ +
Sbjct: 602 AEELHKVIAEKDKQIKQTE--DSLASERDRLTSKEEELKDIQNMNFLLKAEV----QKLQ 655
Query: 430 TLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAV------LWLRNNRDKFKQRVCE 483
L E+ + + + + K+DK+R + + N+++K + +
Sbjct: 656 ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
Query: 484 PIMLTINMKDNKNA-KYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPK 542
+ ++ + NK+ + +E I D + E E +E L +V K+ +NA+
Sbjct: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE--ELLETGLIQVA-TKEEELNAIRTEN 772
Query: 543 SSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIER 602
SS + + Q F S + EL IHE + E +E
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKV-------------IHEKDGKIKSVEELLEA 819
Query: 603 VIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEI 662
+ + K+ + K +K K N L+ AQ L++T +++ ++L + +E
Sbjct: 820 ELLKVANKEKTVQDLKQEIKAL----KEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
Query: 663 HRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLME 722
++AV L E K L + L+ ++E K +++ Q + S E
Sbjct: 876 MNTMKAV------LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE 929
Query: 723 QDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKN 782
+ L+E+E + +++ + ++ ++ T L++ D+ +N S+
Sbjct: 930 ELEIVLKEKENELK-RLEAMLKERESDLSSKTQLLQ----------DVQDENKLFKSQIE 978
Query: 783 KLESDYMAASSQLRLTEQHFIELDENRQRL------LQKCKELMKRARQVCNLGAEQTLP 836
+L+ +S E+ + E + + L K+ ++ R+ N
Sbjct: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN-------- 1030
Query: 837 QEYQTQVPTIPNGHNSSLPMVFQ--DLPNTLDEIDALLTEERSRASCFTGLNPT----IV 890
E Q QV + L +F +P+ L + L E+ C G + + ++
Sbjct: 1031 -ERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1089
Query: 891 QEYTKREEEIEQLT----EELKGKKVE----LDQYRENISQVKERWLNPLKELVEKINEK 942
+ K +E+ L E+ K E L + + ++ Q + +W + E + I +
Sbjct: 1090 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1149
Query: 943 FSNFFSSMQCAGEVD-LHTENEE 964
S+F SS Q E++ L +EN++
Sbjct: 1150 QSSFTSSEQ---ELERLRSENKD 1169
Score = 58.5 bits (140), Expect = 3e-08
Identities = 138/754 (18%), Positives = 305/754 (40%), Gaps = 92/754 (12%)
Query: 215 LKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVE 274
L ++E + CK+ T Q+M+ ER + R +R L+ + + V
Sbjct: 341 LAAVKEDAAATKDRCKQLT---QEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVS 397
Query: 275 YENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLE-ARIKEKATDIKE 333
Y+ +Q + + VR++++ E+ LK+ + + N+ + + A + + D
Sbjct: 398 YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
Query: 334 ASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENC 393
+ +K +++++ + +QA + + + +RR + I E + +
Sbjct: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ-- 515
Query: 394 ENLQPQIDAITNDLRRIQDE--KALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQ 451
++LQ + A N+++ + + L + +++R + +E E+K V+
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL-MQLMESEQKRVN------------ 562
Query: 452 KEDKLRQRFRDTYDAVLWLRNNRDKFKQRV---------CEPIMLTINMKDNKNAKYIEN 502
KE+ L+ + +D + L+ +F ++ E + I KD K K E+
Sbjct: 563 KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD-KQIKQTED 621
Query: 503 HIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADK--APSRSLNELKQ- 559
+ S R E + LK+++ N + A + + A++ A + L +++Q
Sbjct: 622 SLASERDRLTSKEEE------LKDIQ-NMNFLLKAEVQKLQALANEQAAAAHELEKMQQS 674
Query: 560 -YGFFSYLRELFDAPDPVMSYLCCQYHI-HEVPVGTEKTRERIERVIQETRLKQIYTAEE 617
Y +R L + +S ++ I ++ + ++++ ++ E K + E
Sbjct: 675 VYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQME 734
Query: 618 KYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALR 677
K + + + LK + L T L Q EE+L I + ++ + L+
Sbjct: 735 KCIQE----------KDEKLKTVEELLET-GLIQVATKEEELNAIRTENSSLTKEVQDLK 783
Query: 678 ETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKAST 737
+ + + KK + E+ K + +E+ + ++L + E+ +L++E +
Sbjct: 784 AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKE 843
Query: 738 KIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRL 797
+I + ++KA+ ++ +T+ ++ +L K + + V+ EK K L
Sbjct: 844 EIGNVQLEKAQQLS-ITSKVQELQNLLKGKEEQMNTMKAVLEEKEK----------DLAN 892
Query: 798 TEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMV 857
T + +L E + L +E+ + NL + Q L +V
Sbjct: 893 TGKWLQDLQEENESLKAHVQEVAQH-----NLKEASSASQ-------------FEELEIV 934
Query: 858 FQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQY 917
++ N L ++A+L E S S T L + E + +IEQL ++ + +
Sbjct: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
Query: 918 RENISQVKER-------W--LNPLKELVEKINEK 942
E + + ER W L+ LK+ VE +K
Sbjct: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKK 1028
Score = 57.0 bits (136), Expect = 1e-07
Identities = 132/731 (18%), Positives = 285/731 (38%), Gaps = 95/731 (12%)
Query: 126 ELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVG 185
++ + +L R+ +K + I + K +K+ AL + L + +
Sbjct: 615 QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQS 674
Query: 186 EFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMV--QRN 243
+ K KI LLE + E+ E K L ++ K L K + + LQ +V Q N
Sbjct: 675 VYVKDDKIRLLEEQLQH----EISNKMEEFKILNDQNKAL----KSEVQKLQTLVSEQPN 726
Query: 244 ERYKQDVER-FYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLK-- 300
+ + +E+ E+ L +E L + ++ +E ++ + +EV+ LK
Sbjct: 727 KDVVEQMEKCIQEKDEKLKTVEEL-LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK 785
Query: 301 -EGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQAL 359
Q+ +EE++ H + +IK ++ K K+ ++ + I+ L++ +
Sbjct: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
Query: 360 IVKQNEELDRQRRIGNTRKMIEDLQNELKTTENCEN-----LQPQIDAITND---LRRIQ 411
N +L++ +++ T K +++LQN LK E N L+ + + N L+ +Q
Sbjct: 846 ---GNVQLEKAQQLSITSK-VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 412 DEKALCEGEIIDKRRER----------ETLEKEKKSVDDHIVRFDNLMNQKEDKLR---Q 458
+E + + + + E LE K ++ + R + ++ ++E L Q
Sbjct: 902 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQ 961
Query: 459 RFRDTYDAVLWLRNNRDKFKQRVCEPI--------MLTINMKDNKNAKYIENHIPS---- 506
+D D ++ ++ KQ+ + +L + + K + N + S
Sbjct: 962 LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDA 1021
Query: 507 -NDLRAFVFESQEDMEVFLKEVRDN-KKLRVNAVIAPKSSYAD---------KAPSRSLN 555
R E Q+ +E E ++ KKL + SY + K +
Sbjct: 1022 VEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTS 1081
Query: 556 ELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTA 615
++ + + D ++ C +Y V TE ++++R +++
Sbjct: 1082 GSEEVKVLEHKLKEADEMHTLLQLECEKYK--SVLAETEGILQKLQRSVEQE-------- 1131
Query: 616 EEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIA 675
E K+ VK S+K I S F + +LE+ R + ++ + R+
Sbjct: 1132 ENKWKVKVD-ESHKTIKQMQS----SFTSSEQELERLRSENKDIENLRRER--------- 1177
Query: 676 LRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKA 735
EH + EL + + E T+ R+L+ +++ L L+ + + + + KA
Sbjct: 1178 --------EHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKA 1229
Query: 736 STKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQL 795
++ I + K + T + S + + + ++ +L+ A + QL
Sbjct: 1230 QQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1289
Query: 796 RLTEQHFIELD 806
++H+ L+
Sbjct: 1290 TKEKEHYQVLE 1300
Score = 40.8 bits (94), Expect = 0.007
Identities = 134/670 (20%), Positives = 267/670 (39%), Gaps = 121/670 (18%)
Query: 386 ELKTTENCENLQPQIDAITNDLRRIQ--DEKALCEGEIIDKRRERETLEKE--KKSVDDH 441
+LKT + EN + + L+ + +++ALC ++D +E+ + ++ KKS
Sbjct: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALC---VVDLLKEKSGVIQDALKKSSKGE 326
Query: 442 IVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPI-------MLTINMKDN 494
+ + + +K DKL ++ A +D+ KQ E + ++ MKD
Sbjct: 327 LTTLIHQLQEK-DKLLAAVKEDAAAT------KDRCKQLTQEMMTEKERSNVVITRMKDR 379
Query: 495 KNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSL 554
E+++ N + E+Q+ M++ ++VR+ + + A + ++ A S +
Sbjct: 380 IGTLEKEHNVFQNKIHVSYQETQQ-MQMKFQQVREQMEAEI-AHLKQENGILRDAVSNTT 437
Query: 555 NEL--KQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQI 612
N+L KQ + LR Q + V TEKT + + +Q+ +Q
Sbjct: 438 NQLESKQSAELNKLR---------------QDYARLVNELTEKTGKLQQEEVQKKNAEQ- 481
Query: 613 YTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSG 672
+ T LKV QL+E R+ + V S
Sbjct: 482 --------------------AATQLKV------------------QLQEAERRWEEVQSY 503
Query: 673 LIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEE 732
+ + T++H E +L+ K + ++ + + L K++ L S + +EQ L E E
Sbjct: 504 I--RKRTAEH-EAAQQDLQSK---FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE 557
Query: 733 RKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVD------LILQNTTVISEKNK--L 784
+K K + + +Q ++ + L H Q L + VI+EK+K
Sbjct: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
Query: 785 ESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVP 844
+++ AS + RLT + D L K + +++ + + N A E Q
Sbjct: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAE--VQKLQALANEQAAAAHELEKMQQSV 675
Query: 845 TIPNGHNSSLPMVFQ-DLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKRE--EEIE 901
+ + L Q ++ N ++E L + ++ S L T+V E ++ E++E
Sbjct: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ-TLVSEQPNKDVVEQME 734
Query: 902 QLTEELKGKKVELDQYRE-NISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHT 960
+ +E K +++ E + QV + +E + I + S+ +Q DL
Sbjct: 735 KCIQEKDEKLKTVEELLETGLIQVATK-----EEELNAIRTENSSLTKEVQ-----DLKA 784
Query: 961 ENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDE 1020
+ + +V F S + + H + G +SV +L L+ N+ + V +
Sbjct: 785 KQND---------QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK--EKTVQD 833
Query: 1021 INQGMDPINE 1030
+ Q + + E
Sbjct: 834 LKQEIKALKE 843
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 72.4 bits (176), Expect = 2e-12
Identities = 146/747 (19%), Positives = 303/747 (40%), Gaps = 145/747 (19%)
Query: 181 QDKVGEFAKLSKIELLEATEKSIGPPE--MHKYHCELKNLREKEKQLETSCKEKTEYLQK 238
+D E +L+ +L+ATE+ E + + C + +K++ LE K+ +Q+
Sbjct: 1247 RDLKDEIVRLND-SILQATEQRRRAEENALQQKACG-SEIMQKKQHLEIELKQ---VMQQ 1301
Query: 239 MVQRNERYKQDVER----FYERKRHLDLIE---MLEAKRPWVEYEN----VRQEYEE--- 284
+ N R+KQ +E ++ + ++ ++ EAKR W EYEN VR Y+E
Sbjct: 1302 RSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRW-EYENELSKVRNNYDEEII 1360
Query: 285 ---------VKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEAS 335
+ + + + + + +E +I+ + E +L IK + + +
Sbjct: 1361 SLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
Query: 336 QKCKQKQD-----------VIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQ 384
+ ++ ++ V +RK + EL+Q ++ E + ++ + + K I+D
Sbjct: 1421 ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
Query: 385 NELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVR 444
E+ E L+ ID TND + ++DE A + R + L+K S + I
Sbjct: 1481 KEI------ERLKQLIDKETNDRKCLEDENARLQ-------RVQYDLQKANSSATETI-- 1525
Query: 445 FDNLMNQKEDKLRQRFRDTYDAVLWLRNNRD----KFKQRVCEPIMLTINMKDNKNAKYI 500
N + +E +L R R Y+ V R +D +F+ + E + +++ N +
Sbjct: 1526 --NKLKVQEQEL-TRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELN-RLK 1581
Query: 501 ENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQY 560
+ R + E E M LKE + +++ + + A RS ++L+Q
Sbjct: 1582 RTASEDSCKRKKLEEELEGMRRSLKE----QAIKITN-LTQQLEQASIVKKRSEDDLRQQ 1636
Query: 561 GFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYV 620
R++ D H+ E ++T+E + R+ E + +E+
Sbjct: 1637 ------RDVLDG------------HLRE----KQRTQEELRRLSSEVEALRRQLLQEQES 1674
Query: 621 VKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETS 680
VK + N+ K +++E+ + L E L + H + L E
Sbjct: 1675 VKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH----------LMLEEEL 1724
Query: 681 KHLEHKDNELRQKKKE--------LLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEE 732
++L + ++LR+ + E +LE +++ + + G + ++++ NL +E
Sbjct: 1725 RNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEI 1784
Query: 733 RK-------ASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDL------------ILQ 773
K AS +I+E Q ++V E +L+ L K L L+
Sbjct: 1785 EKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLE 1844
Query: 774 NTTVIS-----EKNKLESDYMAASSQLRLTEQHFIELDENRQRL----------LQKCKE 818
T + EK ++++D +Q E+ +++ R++ +++ +
Sbjct: 1845 AETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQA 1904
Query: 819 LMKRARQVCNLGAEQTLPQEYQTQVPT 845
+KR + C E + +E Q+Q+ T
Sbjct: 1905 EIKRIEERCRRKLEDS-TRETQSQLET 1930
Score = 70.5 bits (171), Expect = 8e-12
Identities = 168/878 (19%), Positives = 358/878 (40%), Gaps = 120/878 (13%)
Query: 154 KSTTQKIVEEKVAAL---NIQVGNLCQFLPQD------KVGEF-AKLSKIELLEATEKSI 203
K+T +++EE++ N + N +FL Q+ + +F AKL+ +E L+ +
Sbjct: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
Query: 204 GPP---EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHL 260
G + K + ++K L EK +L +++ + + R ++ K D ++ + +
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR--- 1146
Query: 261 DLIEMLEAKRPWVEYEN---VRQEYEEVKLVRDRVKEEVRKLKEGQIPVTC----RIEEM 313
+ + W + E+ ++++ E++ +R ++EE + +E + + EEM
Sbjct: 1147 ---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEM 1203
Query: 314 ENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEEL-DRQRR 372
N R+ E I T IKE S QK+D + ++ L ++N +L D R
Sbjct: 1204 SNLRNKYETEINITKTTIKEISM---QKEDDSKNLRNQLDRLS-----RENRDLKDEIVR 1255
Query: 373 IGNTRKMIEDLQNELKTTENCENLQPQIDAITNDLRRIQDE-KALCEGEIIDKRRERETL 431
+ ++ +++ + + EN + I + ++ E K + + D R +++L
Sbjct: 1256 LNDS--ILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSL 1313
Query: 432 EKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINM 491
E+ K++ D + L + +++ ++R+ + + + +RNN D+ E I L
Sbjct: 1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRW-EYENELSKVRNNYDE------EIISL---- 1362
Query: 492 KDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPS 551
KN E +I + + +ED + ++ + R N ++ + +
Sbjct: 1363 ---KNQFETEINITKTTIHQLTMQKEEDTSGYRAQI--DNLTRENRSLSEEIKRLKNTLT 1417
Query: 552 RSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQ 611
++ L++ + + + G+E ++ + + ++ ++ Q
Sbjct: 1418 QTTENLRR------------VEEDIQQ---------QKATGSEVSQRKQQLEVELRQVTQ 1456
Query: 612 IYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLE--QRRHLEEQLKEIHRKLQAV 669
+ T E ++ + K I K + L +D E R+ LE++ + R +
Sbjct: 1457 MRTEESVRYKQSLDDAAKTIQDKN--KEIERLKQLIDKETNDRKCLEDENARLQRVQYDL 1514
Query: 670 DSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQL-EQKISSKLGSLKLMEQDTCNL 728
+ ET L+ ++ EL + + + ER +++R + +Q I+ SLK ++ +
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRID-YERVSQERTVKDQDITRFQNSLKELQLQKQKV 1573
Query: 729 EEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDY 788
EEE + E + ++ KL EL + + I+ +L Q K + E D
Sbjct: 1574 EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD- 1632
Query: 789 MAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQ------EYQTQ 842
Q + + H E ++ L + E+ RQ+ L ++++ Q +Q
Sbjct: 1633 --LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQL--LQEQESVKQAHLRNEHFQKA 1688
Query: 843 VPTIPNGHNSSLPMV--FQDLPNTLDEIDALLTEE------------RSRASCFTGLNPT 888
+ N S + Q L L + +L EE R R+ + N T
Sbjct: 1689 IEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNAT 1748
Query: 889 IVQEYTKREEEIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEKFSNFFS 948
I+ E + + T EL+G +L + REN+ Q E++ E +I E S
Sbjct: 1749 IL-ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE------S 1801
Query: 949 SMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHEL 986
QC T+ ++ + ++I+V + +L L
Sbjct: 1802 KNQC-------TQVVQERESLLVKIKVLEQDKARLQRL 1832
Score = 64.3 bits (155), Expect = 6e-10
Identities = 84/367 (22%), Positives = 160/367 (43%), Gaps = 49/367 (13%)
Query: 152 NKKSTTQKIVEEKVAALN-------IQVGNLCQFLPQDKVGEFAKLSKIELLEAT----- 199
++ S +K +EE++ + I++ NL Q L Q + + K S+ +L +
Sbjct: 1585 SEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK--KRSEDDLRQQRDVLDG 1642
Query: 200 ---EKSIGPPEMHKYHCELKNLREKEKQLETSCKE---KTEYLQKMVQRNERY----KQD 249
EK E+ + E++ LR + Q + S K+ + E+ QK ++ R K +
Sbjct: 1643 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE 1702
Query: 250 VERFYE-----RKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKE--- 301
+ER K HL L E L R +EY+++R+ E ++ E+R +
Sbjct: 1703 IERLQSLTENLTKEHLMLEEELRNLR--LEYDDLRRGRSEADSDKNATILELRSQLQISN 1760
Query: 302 -GQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALI 360
+ + I +++ ER NL I++ EAS + ++ ++ + + E L +
Sbjct: 1761 NRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIK 1820
Query: 361 VKQNEELDRQRRIGNTRKMIEDLQNELKTTENCEN-----LQPQIDAITNDLRRIQDEKA 415
V + ++ QR +ED N K+T E L+ + I NDL + + + +
Sbjct: 1821 VLEQDKARLQR--------LEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYS 1872
Query: 416 LCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRD-TYDAVLWLRNNR 474
E I ERE E+EK S+ I R + + E++ R++ D T + L R
Sbjct: 1873 RKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETER 1932
Query: 475 DKFKQRV 481
++++ +
Sbjct: 1933 SRYQREI 1939
Score = 56.6 bits (135), Expect = 1e-07
Identities = 71/376 (18%), Positives = 148/376 (39%), Gaps = 55/376 (14%)
Query: 151 INKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHK 210
I ++ T V ++ L +++ + Q ++ V + L+ K+I + +K
Sbjct: 1430 IQQQKATGSEVSQRKQQLEVELRQVTQMRTEESV------RYKQSLDDAAKTI--QDKNK 1481
Query: 211 YHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKR 270
LK L +KE +++ LQ++ ++ + + ++ E R
Sbjct: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLK----VQEQELTR 1537
Query: 271 PWVEYENVRQE--------------YEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENE 316
++YE V QE +E++L + +V+EE+ +LK +C+ +++E E
Sbjct: 1538 LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE 1597
Query: 317 RHNLEARIKEKATDIKEASQKCKQ----------------------------KQDVIERK 348
+ +KE+A I +Q+ +Q Q+ + R
Sbjct: 1598 LEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRL 1657
Query: 349 DKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTE-NCENLQPQIDAITNDL 407
+E L++ L+ +Q R + +K IED L ++ E LQ + +T +
Sbjct: 1658 SSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 408 RRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAV 467
+++E E D RR R + +K + + + N + +L+ D
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 468 LWLRNNRDKFKQRVCE 483
LR +KF+++ E
Sbjct: 1778 ENLRQEIEKFQKQALE 1793
Score = 53.1 bits (126), Expect = 1e-06
Identities = 146/771 (18%), Positives = 315/771 (40%), Gaps = 143/771 (18%)
Query: 214 ELKNLR----EKEKQLETSCKEKTEYLQKMVQRN-ERYKQDVERFYERKRHLDLIEMLEA 268
+LKN + E+E +L + K + +N ++Y+ + +F + L+ E
Sbjct: 1028 KLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE-----EL 1082
Query: 269 KRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKA 328
KR + + K D+ ++++L E +T IE+ + R ++E R ++
Sbjct: 1083 KR------QAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQK 1136
Query: 329 TDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNE-ELDRQRRI---GNTRKMIEDLQ 384
D + QK +Q E+++ ++L+ +K+ E E++R R + TRK + +
Sbjct: 1137 NDYDQL-QKARQ----CEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRK--REYE 1189
Query: 385 NELKTTENCEN---------LQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEK 435
NEL N N + +I+ ++ I +K E + + R + + L +E
Sbjct: 1190 NELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSREN 1246
Query: 436 KSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNK 495
+ + D IVR ++ + Q ++ R R + +Q+ C ++
Sbjct: 1247 RDLKDEIVRLNDSILQATEQRR-------------RAEENALQQKACGSEIMQKKQHLEI 1293
Query: 496 NAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLN 555
K + ++ R ++ +E K ++D K + K+ + ++A R
Sbjct: 1294 ELKQVMQQRSEDNAR-----HKQSLEEAAKTIQDKNK----EIERLKAEFQEEAKRRWEY 1344
Query: 556 ELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTA 615
E + S +R +D + ++S K + E I +T + Q+
Sbjct: 1345 ENE----LSKVRNNYD--EEIISL---------------KNQFETEINITKTTIHQLTMQ 1383
Query: 616 EEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIA 675
+E+ +TS AQ +T + R L E++K +
Sbjct: 1384 KEE---------------DTSGYRAQIDNLT---RENRSLSEEIKRLKN----------T 1415
Query: 676 LRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLME--QDTCNLEEEER 733
L +T+++L + +++Q+K E +K+QLE ++ ++ ++ E + +L++ +
Sbjct: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVEL-RQVTQMRTEESVRYKQSLDDAAK 1474
Query: 734 KASTKIKEINVQKAKLVTELTNLIKIC--TSLHIQKVDLILQ--NTTVISEKNKLE---- 785
K KEI K +L+ + TN K + +Q+V LQ N++ NKL+
Sbjct: 1475 TIQDKNKEIERLK-QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ 1533
Query: 786 ------SDYMAASSQLRLTEQHFIELDENRQRL---LQKCKELMKRARQVCNLGAEQTLP 836
DY S + + +Q + + L QK +E + R ++ + + +
Sbjct: 1534 ELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
Query: 837 QEYQTQVPTIPNGHNSSLPMVFQDLPNTLDEID-ALLTEERSRASC--FTGLNPTIVQEY 893
E + + G SL + N +++ A + ++RS + ++E
Sbjct: 1594 LEEELE------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREK 1647
Query: 894 TKREEEIEQLTEELKGKKVELDQYRENISQV---KERWLNPLKELVEKINE 941
+ +EE+ +L+ E++ + +L Q +E++ Q E + +++ +NE
Sbjct: 1648 QRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
Score = 49.3 bits (116), Expect = 2e-05
Identities = 50/240 (20%), Positives = 110/240 (45%), Gaps = 25/240 (10%)
Query: 207 EMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEM- 265
E+ K+ + + ++ + C + + + ++ + + +QD R + L+ +
Sbjct: 1783 EIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKST 1842
Query: 266 LEAK-----RPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNL 320
LEA+ R E + ++ + + K R +E +RK++ + E+ E E+++L
Sbjct: 1843 LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESER-------EKSEREKNSL 1895
Query: 321 EARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMI 380
+ I+ +IK ++C++K + R+ + E +++ ++ ++L RQR G+ R
Sbjct: 1896 RSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL-RQRPYGSHR--- 1951
Query: 381 EDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDD 440
+T CE + + LR+ L E ++IDK + L K KKSV++
Sbjct: 1952 -------ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDK-TTLDKLLKGKKSVEE 2003
Score = 43.9 bits (102), Expect = 8e-04
Identities = 75/403 (18%), Positives = 156/403 (38%), Gaps = 43/403 (10%)
Query: 661 EIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKL 720
+ +R L + L L+ + +E + ELR + E K + L+Q +
Sbjct: 1012 DYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQ 1071
Query: 721 MEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISE 780
+ +LEE +R+A K K ++ L + T L + D + +V
Sbjct: 1072 FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR 1131
Query: 781 KNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQ 840
++ ++DY + +++ ++ +++ + ++R R + L E T +EY+
Sbjct: 1132 FDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL--LQEEGTRKREYE 1189
Query: 841 TQVPTIPNGHNSSLPMV----------------------FQDLPNTLDEIDALLTEERSR 878
++ + N +N + + D N +++D L E R
Sbjct: 1190 NELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL 1249
Query: 879 ASCFTGLNPTIVQ--EYTKREEEI--------EQLTEELKGKKVELDQYRENISQVKERW 928
LN +I+Q E +R EE ++ ++ + ++EL Q + S+ R
Sbjct: 1250 KDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARH 1309
Query: 929 LNPLKELVEKI---NEKFSNFFSSMQCAGEVDLHTENE-----EDYDKYGIRIRVKFRSS 980
L+E + I N++ + Q + ENE +YD+ I ++ +F +
Sbjct: 1310 KQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETE 1369
Query: 981 TQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQ 1023
+ + T HQ ++ T Y + L R + +EI +
Sbjct: 1370 INITK-TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKR 1411
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 72.4 bits (176), Expect = 2e-12
Identities = 62/283 (21%), Positives = 145/283 (51%), Gaps = 32/283 (11%)
Query: 207 EMHKYHCELKNLREKEKQLETSCK-----EKT-EYLQKMVQRNERYKQDVERFYERKRHL 260
E + E + +RE+EK+ E K EK E +K+ ++ E+ + E+ +E+++
Sbjct: 455 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIR 514
Query: 261 DLIEMLEAKRPWVEYENVRQEYEEVKLVRDRV---KEEVRKLKEGQIPVTCRIEEMENER 317
+ + E + W + E +R++ EE+ ++++ +E++RK +E ++ E +
Sbjct: 515 EEEKRQEQEEMWRQEEKIREQ-EEIWRQKEKIHEQEEKIRKQEE-------KMWRQEEKM 566
Query: 318 HNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTR 377
H+ E +I+E+ + +K +++++ I +++ I E Q+ + +Q E++ Q
Sbjct: 567 HDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE-QEEMTQEQEEKMGEQE-----E 620
Query: 378 KMIEDLQNELKTTENCENLQPQIDAITNDLRRIQD-EKALCEGEIIDKRRERETLEKEKK 436
KM E E K E E ++ Q + I ++I++ E+ + E E + + +E + E+E+K
Sbjct: 621 KMCE---QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677
Query: 437 SVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQ 479
+ + M ++E+K+R++ ++ + LR +K ++
Sbjct: 678 MCEQ-----EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 55.1 bits (131), Expect = 4e-07
Identities = 94/483 (19%), Positives = 216/483 (44%), Gaps = 58/483 (12%)
Query: 272 WVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDI 331
++E ++ ++L R+ + +E +LKE + +++ +E+E+ ++ +KE +
Sbjct: 255 YIEELTKERDALSLELYRNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL 312
Query: 332 KEASQKCKQKQDVIERKDKHI-EELQ--QALIVKQNEELDRQRRIGNTRKMIEDLQNELK 388
+ A Q+Q ++ + H+ +ELQ A + Q EE + R+ N ++ + + E K
Sbjct: 313 ERAKLLLPQQQ--LQAEADHLGKELQSVSAKLQAQVEENELWNRL-NQQQEEKMWRQEEK 369
Query: 389 TTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNL 448
E E +Q Q + I R Q+EK + E E +R+E EKE+K + R + +
Sbjct: 370 IQEWEEKIQEQEEKI-----REQEEK-IREQEEKMRRQEEMMWEKEEK-----MRRQEEM 418
Query: 449 MNQKEDKLRQRFRDTYDAVLWLRNNR-DKFKQRVCEPIMLTINMKDNKNAKYIENHIPSN 507
M +KE+K+R++ + ++W + + + ++++ E + + + + I
Sbjct: 419 MWEKEEKMRRQ-----EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 473
Query: 508 DLRAFVFESQEDMEVFLKEVR--DNKKLRVNAVIAPKSSYADKAPSRSLNEL-KQYGFFS 564
+ A ++ +E + +++R + K R I + ++ + E+ +Q
Sbjct: 474 EQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 533
Query: 565 YLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRL----KQIYTAEEK-- 618
E++ + IHE K E++ R QE ++ ++I EEK
Sbjct: 534 EQEEIWRQKE----------KIHEQEEKIRKQEEKMWR--QEEKMHDQEEKIREQEEKVW 581
Query: 619 -YVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALR 677
K K+ ++ + +T + E+ EE++ E K+Q
Sbjct: 582 RQEEKIREQEEKIREQEEKIREQEEMTQEQE-EKMGEQEEKMCEQEEKMQ---------- 630
Query: 678 ETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKAST 737
E + + ++ ++R+++K++ E++ K R+ E+ + + + E+ C EE+ ++
Sbjct: 631 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 690
Query: 738 KIK 740
K++
Sbjct: 691 KMR 693
Score = 52.4 bits (124), Expect = 2e-06
Identities = 88/445 (19%), Positives = 191/445 (42%), Gaps = 54/445 (12%)
Query: 310 IEEMENERHNLEARI-KEKATD--IKEASQKCKQKQDVIERKDKHIEELQQALIVKQ-NE 365
IEE+ ER L + + TD +KE + K ++K ++E + I+ L VK+
Sbjct: 256 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ-----LNVKELKR 310
Query: 366 ELDRQRRIGNTRKM---IEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEII 422
+L+R + + +++ + L EL++ Q + + + N L + Q+EK + E I
Sbjct: 311 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 370
Query: 423 DKRRERETLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVC 482
+ E+ ++EK + +R ++E+K+R++ + ++W + K R
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIR------EQEEKMRRQ-----EEMMWEKEE----KMRRQ 415
Query: 483 EPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPK 542
E +M K+ K + E ++E +E + +++ + +K+R +
Sbjct: 416 EEMMWE---KEEKMRRQEE----------MMWEKEEKIRELEEKMHEQEKIREQEEKRQE 462
Query: 543 SSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYH-IHEVPVGTEKTRERIE 601
+ R E K + +RE + + Q IHE EK RE +
Sbjct: 463 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE----QEKIREEEK 518
Query: 602 RVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRH-----LE 656
R QE +Q EEK + + K K+ + E++ H +
Sbjct: 519 RQEQEEMWRQ----EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574
Query: 657 EQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLG 716
EQ +++ R+ + + +RE + + ++ +++++++ E++ K + E+K+ +
Sbjct: 575 EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 634
Query: 717 SLKLMEQDTCNLEEEERKASTKIKE 741
++ E+ E++ R+ KI+E
Sbjct: 635 KMRRQEEKIREQEKKIREQEEKIRE 659
Score = 50.4 bits (119), Expect = 9e-06
Identities = 58/265 (21%), Positives = 122/265 (46%), Gaps = 21/265 (7%)
Query: 230 KEKTEYLQKMVQRNERYKQDVE-RFYERKRHLDLIEMLEAKRPW-VEYENVRQEYEEVKL 287
KEK LQ+ +Q E K +++ E KR L+ ++L ++ E +++ +E + V
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 288 VRDRVKEEVR---KLKEGQIPVTCR----IEEMENERHNLEARIKEKATDIKEASQKCKQ 340
EE +L + Q R I+E E + E +I+E+ I+E +K ++
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400
Query: 341 KQDVIERKDKHIEELQQALIVKQNEELDRQRRI-----GNTRKMIEDLQNELKTTENCEN 395
+++++ K++ + Q+ ++ ++ E++ RQ + R++ E + + K E E
Sbjct: 401 QEEMMWEKEEKMRR-QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 459
Query: 396 LQPQIDAITNDLRRIQDEKALCEGEIIDKRRE--RETLEK----EKKSVDDHIVRFDNLM 449
Q + + R+ Q+ K + E I ++ E RE EK E+K + +R +
Sbjct: 460 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKR 519
Query: 450 NQKEDKLRQRFRDTYDAVLWLRNNR 474
++E+ RQ + +W + +
Sbjct: 520 QEQEEMWRQEEKIREQEEIWRQKEK 544
Score = 37.4 bits (85), Expect = 0.079
Identities = 24/132 (18%), Positives = 69/132 (52%), Gaps = 14/132 (10%)
Query: 194 ELLEATEKSIGPPEMHKYHCELKN-LREKEKQLETSCKEKTEYLQKMVQRNERYKQDVER 252
E+ + E+ +G E + CE + ++E+E+++ ++ E +K+ ++ E+ ++ E
Sbjct: 606 EMTQEQEEKMG--EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 663
Query: 253 FYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEE 312
E++ + W + E + ++ E+++ ++++ + K+ E ++ + + E+
Sbjct: 664 MQEQEEKM-----------WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Query: 313 MENERHNLEARI 324
M+ + +LEA I
Sbjct: 713 MQEHQEHLEAAI 724
Score = 36.6 bits (83), Expect = 0.13
Identities = 87/459 (18%), Positives = 179/459 (38%), Gaps = 72/459 (15%)
Query: 529 DNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQ----- 583
D KK ++N P+++ + S + + LR +A + L CQ
Sbjct: 145 DTKKKKINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQ 204
Query: 584 ----YHIHEVPVGTEKTRERIERVIQETR----LKQIYTAEEKYVVKTSFYSNKVISSNT 635
Y H V + R+ I R+ + L+Q +A K Y ++
Sbjct: 205 MALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERD 264
Query: 636 SLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKK 695
+L + + D E L+E+ ++ KLQ V+S ++ K L+ K ++ K
Sbjct: 265 ALSLELYRNTITDEE----LKEKNAKLQEKLQLVESEKSEIQLNVKELKRK----LERAK 316
Query: 696 ELLERKTKKRQLE------QKISSKLGSL--------KLMEQDTCNLEEEERKASTKIKE 741
LL ++ + + + Q +S+KL + +L +Q + +E K ++
Sbjct: 317 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 376
Query: 742 INVQKAKL------VTELTNLIKICTSLHIQKVDLILQNTTVISEKNKL---------ES 786
I Q+ K+ + E ++ + +K + + + ++ EK + E
Sbjct: 377 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 436
Query: 787 DYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTI 846
+ + ++ EQ I E +++ +K +E KR Q + ++ +E + ++
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI--- 493
Query: 847 PNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEE 906
M Q+ + E + + EE+ + QE R+EE + EE
Sbjct: 494 ---REQEEKMWRQE--EKIHEQEKIREEEKRQE-----------QEEMWRQEEKIREQEE 537
Query: 907 LKGKKVELDQYRENISQVKER-WLNPLK--ELVEKINEK 942
+ +K ++ + E I + +E+ W K + EKI E+
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 71.6 bits (174), Expect = 4e-12
Identities = 126/667 (18%), Positives = 277/667 (41%), Gaps = 135/667 (20%)
Query: 195 LLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFY 254
L + E+S G E+ K EL ++ + +Q +T ++ + L +M + K R
Sbjct: 668 LQQRLEESEG--ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAK----RSE 721
Query: 255 ERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVR-KLKEGQIPVTCRIEEM 313
+R++ + E+L+AK+ + ++E E++ R+R ++ LKE V+ +EM
Sbjct: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE---EVSSHDQEM 778
Query: 314 ENERHNLEARIKEKATDIKEASQKCK--QKQDVIERKDKHIEELQQALIVKQNEEL---- 367
+ + +A ++ ++EA++ + + +D+ E++ L+ ++NE+L
Sbjct: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 368 -DRQRRIGNTRKMIEDLQ-NELKTTENCENLQPQIDAITNDL--------------RRIQ 411
+ +RR+ ++ IEDL+ +E K E + + +I + L R ++
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE 898
Query: 412 DEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQKE----------DKLRQRFR 461
+E +G + +E++ L ++ K + + L N+ E +KL++
Sbjct: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Query: 462 DTYDA----VLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFESQ 517
D +A L L+N D++K++ + M+ K +E + R + Q
Sbjct: 959 DIVEASRTSTLELQNQLDEYKEKNRRELA---EMQRQLKEKTLE----AEKSRLTAMKMQ 1011
Query: 518 EDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVM 577
++M + +E+RD ++ + A+ R L E L++L
Sbjct: 1012 DEMRLMEEELRDYQRAQDEALT-----------KRQLLE-------QTLKDL-------- 1045
Query: 578 SYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSL 637
+Y + E + R R+ + +++ ++ Q+ E+ + S ++ S
Sbjct: 1046 -----EYEL-EAKSHLKDDRSRLVKQMED-KVSQLEMELEEERNNSDLLSERISRSR--- 1095
Query: 638 KVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHLE----HKDNELRQK 693
EQ L +L + Q ++ I+L +K L+ H + R
Sbjct: 1096 ------------EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSS 1143
Query: 694 KKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTEL 753
K+ L+ Q+E +I+ L+ E+D NL+ R+ K+KE+
Sbjct: 1144 KEGLVV------QMEARIAELEDRLESEERDRANLQLSNRRLERKVKEL----------- 1186
Query: 754 TNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLL 813
+ +VD ++ ++ +K++L A Q+ E+ L+ ++++L
Sbjct: 1187 -----------VMQVD--DEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ 1233
Query: 814 QKCKELM 820
++ +E M
Sbjct: 1234 RELEEQM 1240
Score = 62.0 bits (149), Expect = 3e-09
Identities = 149/763 (19%), Positives = 310/763 (40%), Gaps = 141/763 (18%)
Query: 214 ELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWV 273
E+K+L E++ +L E LQ V+ + K+ ER+R +E L ++
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKE------ERERMRANLEELRSQH--- 658
Query: 274 EYENVRQEYEEVKLVRDRVKE---EVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATD 330
++ EE ++ R++E E+RK E V E+ + E +L+ ++ E +
Sbjct: 659 -----NEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 331 IKEASQ-KCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKT 389
+ A + + ++K +IE + ++LQ LI K+ +E ++R + L+ E+ +
Sbjct: 714 LDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSS 773
Query: 390 -TENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNL 448
+ + L+ Q DA LR +E A E++ R T E+++ + + L
Sbjct: 774 HDQEMDKLKEQYDAELQALRESVEE-ATKNVEVLASRSN--TSEQDQAGTEMRV----KL 826
Query: 449 MNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSND 508
+ ++ +KL+ R ++ ++RV + ++ I D
Sbjct: 827 LQEENEKLQGR--------------SEELERRVAQ----------------LQRQI--ED 854
Query: 509 LRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYLRE 568
L+ +++E ++ + E+R ++ V+A K + + + + E Q +E
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE 914
Query: 569 LFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTSFYSN 628
+EK +E E+ Q RLK E ++ KT
Sbjct: 915 QKQL--------------------SEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ 954
Query: 629 K-----VISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKHL 683
K V +S TS Q + RR L E +++ K + + + +
Sbjct: 955 KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM 1014
Query: 684 EHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEIN 743
+ ELR ++ E TK++ LEQ + E E +A + +K+
Sbjct: 1015 RLMEEELRDYQRAQDEALTKRQLLEQTLKDL---------------EYELEAKSHLKD-- 1057
Query: 744 VQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQHFI 803
+++LV ++ + + ++++ L E+ + SD ++ R EQ
Sbjct: 1058 -DRSRLVKQMED--------KVSQLEMEL-------EEERNNSDLLSERIS-RSREQ--- 1097
Query: 804 ELDENRQRLLQKCKELMKRARQ--VCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDL 861
+++ R LLQ+ + ARQ C+ + + ++ ++++ + + SS + +
Sbjct: 1098 -MEQLRNELLQE-----RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQM 1151
Query: 862 PNTLDEI-DALLTEERSRASCFTG----------LNPTIVQEYTKREEEIEQLTEELKGK 910
+ E+ D L +EER RA+ L + E+ ++ +QL+ LK
Sbjct: 1152 EARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAM 1211
Query: 911 KVELDQYRENISQVKERWLNPLKELVEK--INEKFSNFFSSMQ 951
K ++++ E I +++ +EL E+ +NE +SM+
Sbjct: 1212 KRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
Score = 61.6 bits (148), Expect = 4e-09
Identities = 127/671 (18%), Positives = 260/671 (38%), Gaps = 121/671 (18%)
Query: 320 LEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKM 379
L++R A +A + +D++E+K K E+ EL RQ
Sbjct: 588 LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA---------ELQRQ--------- 629
Query: 380 IEDLQNELKTTENCENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVD 439
LQ E+K +N + + ++ A +LR +EK E + +R E E K +
Sbjct: 630 ---LQLEVKNQQNIKEERERMRANLEELRSQHNEKVE-ENSTLQQRLEESEGELRKNLEE 685
Query: 440 DHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKY 499
V+ + +Q E RD D + + + D K+ +D +
Sbjct: 686 LFQVKMEREQHQTE------IRDLQDQLSEMHDELDSAKRS-----------EDREKGAL 728
Query: 500 IENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQ 559
IE + + + +D+ + +E D + R + A K + ++ S K
Sbjct: 729 IEELLQAK-------QDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK- 780
Query: 560 YGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKY 619
L+E +DA + RE +E +
Sbjct: 781 ------LKEQYDAE-------------------LQALRESVEEATKNVE----------- 804
Query: 620 VVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQR-RHLEEQLKEIHRKLQAVDSGLIALRE 678
V+ + +++ + T ++V L+ R LE ++ ++ R+++ + +E
Sbjct: 805 VLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 679 TSKHLEHKDNELRQK----KKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERK 734
T K E + +L + +KE E + +R LE ++ + G+L Q+ L E+ ++
Sbjct: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE 924
Query: 735 ASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLI-LQNTTVISEKNKLESDYMAASS 793
S + +++ K ++ E +L K L + D++ T+ + +N+L+
Sbjct: 925 ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD-------- 976
Query: 794 QLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSS 853
E++ EL E +++L +K E K + E L +E + +
Sbjct: 977 --EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTK 1034
Query: 854 LPMVFQDLPNTLDEIDAL--LTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKK 911
++ Q L + E++A L ++RSR + E+++ QL EL+ ++
Sbjct: 1035 RQLLEQTLKDLEYELEAKSHLKDDRSRL-------------VKQMEDKVSQLEMELEEER 1081
Query: 912 VELDQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGI 971
D E IS+ +E+ EL+++ + ++C ++ L +N +D I
Sbjct: 1082 NNSDLLSERISRSREQMEQLRNELLQERAAR-----QDLEC-DKISLERQN-KDLKSRII 1134
Query: 972 RIRVKFRSSTQ 982
+ +RSS +
Sbjct: 1135 HLEGSYRSSKE 1145
Score = 42.4 bits (98), Expect = 0.002
Identities = 71/386 (18%), Positives = 171/386 (44%), Gaps = 33/386 (8%)
Query: 119 SRGMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQF 178
+R +E EL A GNL T + ++ +++ + ++ ++ +G +
Sbjct: 893 ARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEK 952
Query: 179 LPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNLREKEKQLETSCKEKTEYLQK 238
L Q ++ + + S+ LE + E ++ + KEK LE EK+
Sbjct: 953 L-QKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEA---EKSRLTAM 1008
Query: 239 MVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRK 298
+Q R ++ R Y+R + L KR +E EYE + +K++ +
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEAL-----TKRQLLEQTLKDLEYELE--AKSHLKDDRSR 1061
Query: 299 LKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEELQQA 358
L +++ME++ LE ++E+ + S++ + ++ +E+ EL Q
Sbjct: 1062 L----------VKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLR---NELLQE 1108
Query: 359 LIVKQNEELDR---QRRIGNTRKMIEDLQNELKTTENCENLQPQIDAITNDL--RRIQDE 413
+Q+ E D+ +R+ + + I L+ ++++ E L Q++A +L R +E
Sbjct: 1109 RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSK--EGLVVQMEARIAELEDRLESEE 1166
Query: 414 KALCEGEIIDKRRERETLEKEKKSVDDHIVRFD--NLMNQKEDKLRQRFRDTYDAVLWLR 471
+ ++ ++R ER+ E + D+H+ D + ++ + ++++ + + + L
Sbjct: 1167 RDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLE 1226
Query: 472 NNRDKFKQRVCEPIMLTINMKDNKNA 497
+++ K ++ + E + + +++ N+
Sbjct: 1227 SSKKKLQRELEEQMDMNEHLQGQLNS 1252
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 71.2 bits (173), Expect = 5e-12
Identities = 158/809 (19%), Positives = 324/809 (40%), Gaps = 130/809 (16%)
Query: 210 KYHCELKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAK 269
K EL LR+ +L EKT LQ+ E K++ E+ + + +++ EA+
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKLQQ----EEVQKKNAEQAATQLK----VQLQEAE 494
Query: 270 RPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKAT 329
R W E ++ +R R E + Q + + ENE +L +++ +
Sbjct: 495 RRWEEVQSY---------IRKRTAEH----EAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 330 DIKEASQKCKQKQDVIERKDKHIEELQQAL--IVKQNEELDRQRRIGNTR---------- 377
++ Q+ Q + +++ E LQ + I++QNE L Q + +++
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 378 -----KMIEDLQNELKTTENCENLQPQIDAITN---DLRRIQDEKALCEGEIIDKRRERE 429
K+I + ++K TE ++L + D +T+ +L+ IQ+ L + E+ ++ +
Sbjct: 602 AEELHKVIAEKDKQIKQTE--DSLASERDRLTSKEEELKDIQNMNFLLKAEV----QKLQ 655
Query: 430 TLEKEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAV------LWLRNNRDKFKQRVCE 483
L E+ + + + + K+DK+R + + N+++K + +
Sbjct: 656 ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQ 715
Query: 484 PIMLTINMKDNKNA-KYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPK 542
+ ++ + NK+ + +E I D + E E +E L +V K+ +NA+
Sbjct: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVE--ELLETGLIQVA-TKEEELNAIRTEN 772
Query: 543 SSYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIER 602
SS + + Q F S + EL IHE + + +E
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKV-------------IHE----KDGKIKSVEE 815
Query: 603 VIQETRLKQIYTAEEKYVVKTSFYSN-KVISSNTSLKVAQFLTVTVDLEQR--------- 652
+++ LK A ++ V+ S S + + + K Q T+ LE++
Sbjct: 816 LLEAELLK---VANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 872
Query: 653 --RHLEEQLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQK 710
+ L+E+ + + +Q V + ++ E + L++K+ EL + ++ E
Sbjct: 873 WLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD 932
Query: 711 ISSKLGSLKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDL 770
+SSK L QD + + + ++K+ N Q+A L+K
Sbjct: 933 LSSKTQLL----QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLK------------ 976
Query: 771 ILQNTTVISEKNKLESDYMAASSQLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLG 830
VISE+ K S L+ +H + + + + + E + ++
Sbjct: 977 ------VISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1030
Query: 831 AEQTLPQEYQTQVPTIPNGHNSSLPMVFQ--DLPNTLDEIDALLTEERSRASCFTGLNPT 888
+T +E Q QV + L +F +P+ L + L E+ C G + +
Sbjct: 1031 VNKT-SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1089
Query: 889 ----IVQEYTKREEEIEQLT----EELKGKKVE----LDQYRENISQVKERWLNPLKELV 936
+++ K +E+ L E+ K E L + + ++ Q + +W + E
Sbjct: 1090 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1149
Query: 937 EKINEKFSNFFSSMQCAGEVD-LHTENEE 964
+ I + S+F SS Q E++ L +EN++
Sbjct: 1150 KTIKQMQSSFTSSEQ---ELERLRSENKD 1175
Score = 59.7 bits (143), Expect = 1e-08
Identities = 142/750 (18%), Positives = 296/750 (39%), Gaps = 107/750 (14%)
Query: 215 LKNLREKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVE 274
L ++E + CK+ T Q+M+ ER + R +R L+ + + V
Sbjct: 341 LAAVKEDAAATKDRCKQLT---QEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVS 397
Query: 275 YENVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLE-ARIKEKATDIKE 333
Y+ +Q + + VR++++ E+ LK+ + + N+ + + A + + D
Sbjct: 398 YQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
Query: 334 ASQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTENC 393
+ +K +++++ + +QA + + + +RR + I E + +
Sbjct: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ-- 515
Query: 394 ENLQPQIDAITNDLRRIQDE--KALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQ 451
++LQ + A N+++ + + L + +++R + +E E+K V+
Sbjct: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL-MQLMESEQKRVN------------ 562
Query: 452 KEDKLRQRFRDTYDAVLWLRNNRDKFKQRV---------CEPIMLTINMKDNKNAKYIEN 502
KE+ L+ + +D + L+ +F ++ E + I KD K K E+
Sbjct: 563 KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKD-KQIKQTED 621
Query: 503 HIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGF 562
+ S R E + LK+++ N + A + + A++ + + +EL++
Sbjct: 622 SLASERDRLTSKEEE------LKDIQ-NMNFLLKAEVQKLQALANE-QAAAAHELEKMQQ 673
Query: 563 FSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVK 622
Y+++ + + E + E + + E I + K + + +K
Sbjct: 674 SVYVKD-------------DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 623 TSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHR-KLQAVDSGLIALRETSK 681
S NK + V Q + +++ E+L E ++ + L A+R +
Sbjct: 721 VSEQPNKDV-------VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENS 773
Query: 682 HLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKE 741
L + +L+ K+ + + + +L++ I K G +K +E+ LE E K + K K
Sbjct: 774 SLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANKEKT 830
Query: 742 INVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLTEQH 801
+ + V EL NL+K K + + V+ EK K L T +
Sbjct: 831 VQLSITSKVQELQNLLK-------GKEEQMNTMKAVLEEKEK----------DLANTGKW 873
Query: 802 FIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPMVFQDL 861
+L E + L +E+ + NL + Q L +V ++
Sbjct: 874 LQDLQEENESLKAHVQEVAQH-----NLKEASSASQ-------------FEELEIVLKEK 915
Query: 862 PNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVELDQYRENI 921
N L ++A+L E S S T L + E + +IEQL ++ + + E +
Sbjct: 916 ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL 975
Query: 922 SQVKER-------W--LNPLKELVEKINEK 942
+ ER W L+ LK+ VE +K
Sbjct: 976 KVISEREKEISGLWNELDSLKDAVEHQRKK 1005
Score = 57.8 bits (138), Expect = 6e-08
Identities = 148/824 (17%), Positives = 327/824 (39%), Gaps = 119/824 (14%)
Query: 186 EFAKLSKIELLEATEKSIGPPEMHKYHCE--LKNLREKEKQLETSCKEKTEYLQKMVQRN 243
++A+L EL E T K + E+ K + E L+ + ++ E +E Y++K +
Sbjct: 454 DYARLVN-ELTEKTGK-LQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEH 511
Query: 244 ERYKQDVERFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLVRDRVKEEVRKLKEGQ 303
E +QD++ + K + ++ L +K + V ++ E +L++ E+ R KE
Sbjct: 512 EAAQQDLQSKFVAKENE--VQSLHSK---LTDTLVSKQQLEQRLMQLMESEQKRVNKEES 566
Query: 304 IPVTCRIEEMENERHNLEARIKEKATDIK---EASQKCKQKQDVIERKDKHIEELQQALI 360
+ + +++++ + L+A+I++ + I AS ++ VI KDK I++ + +L
Sbjct: 567 LQM--QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLA 624
Query: 361 VKQNEELDRQRRIGNTRKM----------IEDLQNE-LKTTENCENLQPQIDAITNDLRR 409
+++ ++ + + + M ++ L NE E +Q + + +R
Sbjct: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRL 684
Query: 410 IQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMNQ----------------KE 453
++++ + EI +K E + L + K++ + + L+++ K+
Sbjct: 685 LEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKD 741
Query: 454 DKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPS--NDLRA 511
+KL+ ++ + ++ E LT ++D K + + S +L+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
Query: 512 FVFES-------QEDMEVFLKEVRDNKKLRVNAVIAPKSSYAD---KAPSRSLNELKQY- 560
+ E +E +E L +V NK+ V I K K +N +K
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVA-NKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVL 860
Query: 561 --------GFFSYLRELFDAPDPVMSYL--CCQYHIHEVPVGTEKTRERIERVIQETRLK 610
+L++L + + + +++ Q+++ E ++ I +E LK
Sbjct: 861 EEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK 920
Query: 611 QIYTA----EEKYVVKTSFYS-----NKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKE 661
++ E KT NK+ S Q L + + E
Sbjct: 921 RLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISE 980
Query: 662 IHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLM 721
+++ + + L +L++ +H K+N+LR+K E +E L S + M
Sbjct: 981 REKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAME--------------ALASTEKM 1026
Query: 722 EQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEK 781
QD N +ER+ +++ + ++ +++ +L + + ++L + +
Sbjct: 1027 LQDKVNKTSKERQ--QQVEAVELEAKEVLKKLFPKVSVPSNLSYGE---------WLHGF 1075
Query: 782 NKLESDYMAASS---QLRLTEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQE 838
K + MA +S ++++ E E DE L +C++ L + + Q+
Sbjct: 1076 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS------VLAETEGILQK 1129
Query: 839 YQTQVPTIPNGHNSSLPMVFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREE 898
Q V N + + T+ ++ + T N I E +RE
Sbjct: 1130 LQRSVEQEEN----KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDI--ENLRRER 1183
Query: 899 EIEQLTEELKGKKVELDQYRENISQVKERWLNPLKELVEKINEK 942
E L EL+ ++E Y + ++K + L +L + NE+
Sbjct: 1184 --EHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNER 1225
Score = 57.0 bits (136), Expect = 1e-07
Identities = 137/749 (18%), Positives = 296/749 (39%), Gaps = 125/749 (16%)
Query: 126 ELFRASGNLVITREIDVAKNQSFWFINKKSTTQKIVEEKVAALNIQVGNLCQFLPQDKVG 185
++ + +L R+ +K + I + K +K+ AL + L + +
Sbjct: 615 QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQS 674
Query: 186 EFAKLSKIELLEAT---EKSIGPPEMHKYHCELKNLREKEKQLETSCKEK-----TEYLQ 237
+ K KI LLE E S E + + K L+ + ++L+T E+ E ++
Sbjct: 675 VYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQME 734
Query: 238 KMVQRNERYKQDVERFYE--------RKRHLDLIEM-----------LEAKR-PWVEYEN 277
K +Q + + VE E ++ L+ I L+AK+ V + +
Sbjct: 735 KCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFAS 794
Query: 278 VRQEYEEV--------KLVRDRVKEEVRKL----KEGQIPVTCRIEEMEN-------ERH 318
+ +E ++V K V + ++ E+ K+ K Q+ +T +++E++N + +
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMN 854
Query: 319 NLEARIKEKATDIKEASQKCKQKQDVIERKDKHIEE-----LQQALIVKQNEELDRQRRI 373
++A ++EK D+ + + Q+ E H++E L++A Q EEL+
Sbjct: 855 TMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI---- 910
Query: 374 GNTRKMIEDLQNELKTTENC-ENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLE 432
++++ +NELK E + + + + T L+ +QDE L + +I ++ +++ +
Sbjct: 911 -----VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI-EQLKQQNYQQ 964
Query: 433 KEKKSVDDHIVRFDNLMNQKEDKLRQRFRDTYDAVLWLRNNRDKFKQR---VCEPIMLTI 489
+ +++ + ++ L DAV R + +++ E + T
Sbjct: 965 ASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1024
Query: 490 NM---KDNKNAKYIENHIPSNDLRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYA 546
M K NK +K + + + +L A KEV KKL + SY
Sbjct: 1025 KMLQDKVNKTSKERQQQVEAVELEA-------------KEVL--KKLFPKVSVPSNLSYG 1069
Query: 547 D---------KAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTEKTR 597
+ K + ++ + + D ++ C +Y V TE
Sbjct: 1070 EWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK--SVLAETEGIL 1127
Query: 598 ERIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEE 657
++++R +++ E K+ VK S+K I S F + +LE+ R +
Sbjct: 1128 QKLQRSVEQE--------ENKWKVKVD-ESHKTIKQMQS----SFTSSEQELERLRSENK 1174
Query: 658 QLKEIHRKLQAVDSGLIALRETSKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGS 717
++ + R+ EH + EL + + E T+ R+L+ +++ L
Sbjct: 1175 DIENLRRER-----------------EHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1217
Query: 718 LKLMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTV 777
L+ + + + + KA ++ I + K + T + S + + + ++
Sbjct: 1218 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1277
Query: 778 ISEKNKLESDYMAASSQLRLTEQHFIELD 806
+L+ A + QL ++H+ L+
Sbjct: 1278 NQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,102,366
Number of Sequences: 37866
Number of extensions: 1892432
Number of successful extensions: 20870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 275
Number of HSP's successfully gapped in prelim test: 955
Number of HSP's that attempted gapping in prelim test: 11160
Number of HSP's gapped (non-prelim): 6622
length of query: 1101
length of database: 18,247,518
effective HSP length: 113
effective length of query: 988
effective length of database: 13,968,660
effective search space: 13801036080
effective search space used: 13801036080
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.