BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo sapiens] (554 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo s... 1090 0.0 gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo s... 1083 0.0 gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s... 954 0.0 gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s... 946 0.0 gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa... 292 5e-79 gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa... 291 1e-78 gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo s... 279 4e-75 gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo s... 279 4e-75 gi|54144631 phosphatase and actin regulator 1 [Homo sapiens] 270 3e-72 gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sa... 224 2e-58 gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 54 5e-07 gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sap... 53 8e-07 gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 52 1e-06 gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 52 2e-06 gi|238624188 diffuse panbronchiolitis critical region 1 protein ... 50 4e-06 gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 50 5e-06 gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit... 49 9e-06 gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 49 9e-06 gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 49 9e-06 gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens] 47 3e-05 gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 47 6e-05 gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 46 8e-05 gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 46 8e-05 gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens] 46 8e-05 gi|92859701 myosin VI [Homo sapiens] 46 8e-05 gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi... 46 8e-05 gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo sap... 46 1e-04 gi|118498337 HECT domain containing 1 [Homo sapiens] 45 1e-04 gi|145580582 uromodulin-like 1 isoform 2 precursor [Homo sapiens] 45 2e-04 gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 45 2e-04 >gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo sapiens] Length = 554 Score = 1090 bits (2820), Expect = 0.0 Identities = 554/554 (100%), Positives = 554/554 (100%) Query: 1 MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60 MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA Sbjct: 1 MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60 Query: 61 VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120 VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE Sbjct: 61 VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120 Query: 121 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 180 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT Sbjct: 121 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 180 Query: 181 VGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 240 VGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF Sbjct: 181 VGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 240 Query: 241 KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT 300 KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT Sbjct: 241 KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT 300 Query: 301 NRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360 NRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA Sbjct: 301 NRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360 Query: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQR 420 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQR Sbjct: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQR 420 Query: 421 TSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLS 480 TSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLS Sbjct: 421 TSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLS 480 Query: 481 LRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEME 540 LRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEME Sbjct: 481 LRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEME 540 Query: 541 VHEESRQFTRFHRP 554 VHEESRQFTRFHRP Sbjct: 541 VHEESRQFTRFHRP 554 >gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo sapiens] Length = 565 Score = 1083 bits (2800), Expect = 0.0 Identities = 550/551 (99%), Positives = 551/551 (100%) Query: 4 AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63 +VDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE Sbjct: 15 SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 74 Query: 64 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG Sbjct: 75 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 134 Query: 124 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 183 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT Sbjct: 135 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 194 Query: 184 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 243 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM Sbjct: 195 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 254 Query: 244 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT 303 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT Sbjct: 255 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT 314 Query: 304 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS 363 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS Sbjct: 315 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS 374 Query: 364 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE 423 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE Sbjct: 375 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE 434 Query: 424 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP 483 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP Sbjct: 435 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP 494 Query: 484 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE 543 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE Sbjct: 495 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE 554 Query: 544 ESRQFTRFHRP 554 ESRQFTRFHRP Sbjct: 555 ESRQFTRFHRP 565 >gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo sapiens] Length = 634 Score = 954 bits (2466), Expect = 0.0 Identities = 510/634 (80%), Positives = 525/634 (82%), Gaps = 80/634 (12%) Query: 1 MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60 MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA Sbjct: 1 MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60 Query: 61 VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120 VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE Sbjct: 61 VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120 Query: 121 GNGSVSEKTPPLEEQAEDKK---------------------------------------- 140 GNGSVSEKTPPLEEQAEDKK Sbjct: 121 GNGSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGAT 180 Query: 141 AGSSH----------SKKTTGSKA------SASPSTSSTSSRPKASKETVSSKAG---TV 181 AG+SH + K G +A AS +T+ ++ SK+T SKA + Sbjct: 181 AGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPST 240 Query: 182 GTTKGKRKTDKQPITSHLSSDTTTSG---------------------TSDLKGEPAETRV 220 +T + K K+ ++S + TT G TSDLKGEPAETRV Sbjct: 241 SSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRV 300 Query: 221 ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG 280 ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG Sbjct: 301 ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG 360 Query: 281 ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM 340 ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM Sbjct: 361 ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM 420 Query: 341 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA 400 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA Sbjct: 421 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA 480 Query: 401 IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKN 460 IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKN Sbjct: 481 IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKN 540 Query: 461 EEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 520 EEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT Sbjct: 541 EEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 600 Query: 521 PADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554 PADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP Sbjct: 601 PADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 634 >gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo sapiens] Length = 645 Score = 946 bits (2446), Expect = 0.0 Identities = 506/631 (80%), Positives = 522/631 (82%), Gaps = 80/631 (12%) Query: 4 AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63 +VDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE Sbjct: 15 SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 74 Query: 64 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG Sbjct: 75 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 134 Query: 124 SVSEKTPPLEEQAEDKK----------------------------------------AGS 143 SVSEKTPPLEEQAEDKK AG+ Sbjct: 135 SVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGA 194 Query: 144 SH----------SKKTTGSKA------SASPSTSSTSSRPKASKETVSSKAG---TVGTT 184 SH + K G +A AS +T+ ++ SK+T SKA + +T Sbjct: 195 SHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSST 254 Query: 185 KGKRKTDKQPITSHLSSDTTTSG---------------------TSDLKGEPAETRVESF 223 + K K+ ++S + TT G TSDLKGEPAETRVESF Sbjct: 255 SSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESF 314 Query: 224 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL 283 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL Sbjct: 315 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL 374 Query: 284 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 343 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES Sbjct: 375 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 434 Query: 344 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL 403 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL Sbjct: 435 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL 494 Query: 404 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE 463 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE Sbjct: 495 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE 554 Query: 464 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD 523 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD Sbjct: 555 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD 614 Query: 524 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP Sbjct: 615 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 645 >gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sapiens] Length = 559 Score = 292 bits (748), Expect = 5e-79 Identities = 203/558 (36%), Positives = 295/558 (52%), Gaps = 47/558 (8%) Query: 6 DGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERK 65 D +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K Sbjct: 40 DEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKK 98 Query: 66 ISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSV 125 ++ RQ REELI++G+L E+ +QD + + + + + E + + GS Sbjct: 99 MAGRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGS- 156 Query: 126 SEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185 PL + S A+ PS SS + AG++ Sbjct: 157 -----PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE----------ADAGSL---- 197 Query: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMV 244 P T+ LS + + D P E V +P + + K K++ Sbjct: 198 -------LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVT 250 Query: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304 + A S + L Q T + +P L +V LP S + +L A +R Sbjct: 251 GQATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQD 308 Query: 305 LYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360 + G G R + + T E GK + + E+ + + +E Sbjct: 309 SFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLII 368 Query: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNI 417 N D +LY +DE+ +S ++ + R+ + LA+KL NRPSK+ELED+NI Sbjct: 369 NSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNI 421 Query: 418 LQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSR 477 R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE + E+K+RL+R Sbjct: 422 FPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTR 481 Query: 478 KLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKS 536 KL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAAIRKELNE+KS Sbjct: 482 KLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKS 541 Query: 537 TEMEVHEESRQFTRFHRP 554 EMEVH S+ TRFHRP Sbjct: 542 NEMEVHASSKHLTRFHRP 559 >gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sapiens] Length = 518 Score = 291 bits (744), Expect = 1e-78 Identities = 202/556 (36%), Positives = 294/556 (52%), Gaps = 47/556 (8%) Query: 8 LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 67 +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++ Sbjct: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59 Query: 68 TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSE 127 RQ REELI++G+L E+ +QD + + + + + E + + GS Sbjct: 60 GRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGS--- 115 Query: 128 KTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGK 187 PL + S A+ PS SS + AG++ Sbjct: 116 ---PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE----------ADAGSL------ 156 Query: 188 RKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMVPP 246 P T+ LS + + D P E V +P + + K K++ Sbjct: 157 -----LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQ 211 Query: 247 PPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLY 306 + A S + L Q T + +P L +V LP S + +L A +R + Sbjct: 212 ATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQDSF 269 Query: 307 SGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQAND 362 G G R + + T E GK + + E+ + + +E N Sbjct: 270 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 329 Query: 363 SDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNILQ 419 D +LY +DE+ +S ++ + R+ + LA+KL NRPSK+ELED+NI Sbjct: 330 ELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 382 Query: 420 RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKL 479 R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE + E+K+RL+RKL Sbjct: 383 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 442 Query: 480 SLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTE 538 + RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAAIRKELNE+KS E Sbjct: 443 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 502 Query: 539 MEVHEESRQFTRFHRP 554 MEVH S+ TRFHRP Sbjct: 503 MEVHASSKHLTRFHRP 518 >gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo sapiens] Length = 712 Score = 279 bits (714), Expect = 4e-75 Identities = 192/462 (41%), Positives = 258/462 (55%), Gaps = 29/462 (6%) Query: 103 IPIGEESTREENVVKSE-----EGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 157 IP + + R N V +E +S+ +PPL K+ S S T S A+ + Sbjct: 270 IPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPP----KRGIPSTSVPTLESAAAIT 325 Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE 217 T P +E + G+ ++ P+ +H+ + + K Sbjct: 326 TKT------PSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVV 379 Query: 218 TRVE---SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 274 +E S L Q +P E+Q K ++ P PPLPL + A +P+ Sbjct: 380 PEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPL 439 Query: 275 VLVSV--GADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVP 332 + + G+ S L + ++E+ + TL L + E K +EE +T P Sbjct: 440 PMTPILEGSHRAHSLLFENSDSFSEDSS---TLGRTRSLPITIEMLKVPDDEEEEEQTCP 496 Query: 333 QLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASK 392 + M +S + E + +DSDS+GPI Y D+EDEDE S +SALA+K Sbjct: 497 STFSEE-MTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDE----SYQSALANK 551 Query: 393 IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQ 452 ++R+DTLA+KL +RPS+ EL + N S+EE EIR QIG L+RRLSQRPT EELEQ Sbjct: 552 VKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ 610 Query: 453 RNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRA 512 RNIL+ KNE + Q K E+KRRL+RKLS RPTVAEL AR+ILRFNEYVEVTD+ DYDRRA Sbjct: 611 RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA 670 Query: 513 DKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554 DKPW +LTPADKAAIRKELNEFKS+EMEVHEES+ FTR+HRP Sbjct: 671 DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 712 Score = 126 bits (316), Expect = 6e-29 Identities = 106/340 (31%), Positives = 151/340 (44%), Gaps = 29/340 (8%) Query: 17 DGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELI 76 D AG TPP KRK K S GKIFKPWKWRKKK+SDKF+ETS VLERKIS R+ REEL+ Sbjct: 30 DSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELV 89 Query: 77 RRGVLKELPDQDGDVTVNFENS---NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLE 133 +RGVL E P+Q G+ ++ NGH PIG + R + V+ EE ++ + Sbjct: 90 KRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIG--NARSSSPVQVEEEPVRLASLRKAIP 147 Query: 134 EQAEDKKAGSSHSKKTTGS--------KASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185 E+ K+ GS+ S+ + + K P SS +AS+ + GT + Sbjct: 148 EEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTAR 207 Query: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA-EEQNTGKFKSMV 244 T + ++ T+ + T +L P+ +T+P A NT S+ Sbjct: 208 FIISTSITTAPAATTAATSLAKTVNLSVTPSPA-------PRTLPAAPASTNTTATPSLT 260 Query: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304 P P P P + A + + P L P + + T+ T Sbjct: 261 HMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGI---PSTSVPT 317 Query: 305 LYSGTGL-----SVNRENAKCFTTKEELGKTVPQLLTPGL 339 L S + S RE + C E L P+ +P L Sbjct: 318 LESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPL 357 >gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo sapiens] Length = 702 Score = 279 bits (714), Expect = 4e-75 Identities = 192/462 (41%), Positives = 258/462 (55%), Gaps = 29/462 (6%) Query: 103 IPIGEESTREENVVKSE-----EGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 157 IP + + R N V +E +S+ +PPL K+ S S T S A+ + Sbjct: 260 IPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPP----KRGIPSTSVPTLESAAAIT 315 Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE 217 T P +E + G+ ++ P+ +H+ + + K Sbjct: 316 TKT------PSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVV 369 Query: 218 TRVE---SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 274 +E S L Q +P E+Q K ++ P PPLPL + A +P+ Sbjct: 370 PEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPL 429 Query: 275 VLVSV--GADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVP 332 + + G+ S L + ++E+ + TL L + E K +EE +T P Sbjct: 430 PMTPILEGSHRAHSLLFENSDSFSEDSS---TLGRTRSLPITIEMLKVPDDEEEEEQTCP 486 Query: 333 QLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASK 392 + M +S + E + +DSDS+GPI Y D+EDEDE S +SALA+K Sbjct: 487 STFSEE-MTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDE----SYQSALANK 541 Query: 393 IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQ 452 ++R+DTLA+KL +RPS+ EL + N S+EE EIR QIG L+RRLSQRPT EELEQ Sbjct: 542 VKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ 600 Query: 453 RNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRA 512 RNIL+ KNE + Q K E+KRRL+RKLS RPTVAEL AR+ILRFNEYVEVTD+ DYDRRA Sbjct: 601 RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA 660 Query: 513 DKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554 DKPW +LTPADKAAIRKELNEFKS+EMEVHEES+ FTR+HRP Sbjct: 661 DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 702 Score = 126 bits (316), Expect = 6e-29 Identities = 106/340 (31%), Positives = 151/340 (44%), Gaps = 29/340 (8%) Query: 17 DGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELI 76 D AG TPP KRK K S GKIFKPWKWRKKK+SDKF+ETS VLERKIS R+ REEL+ Sbjct: 20 DSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELV 79 Query: 77 RRGVLKELPDQDGDVTVNFENS---NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLE 133 +RGVL E P+Q G+ ++ NGH PIG + R + V+ EE ++ + Sbjct: 80 KRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIG--NARSSSPVQVEEEPVRLASLRKAIP 137 Query: 134 EQAEDKKAGSSHSKKTTGS--------KASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185 E+ K+ GS+ S+ + + K P SS +AS+ + GT + Sbjct: 138 EEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTAR 197 Query: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA-EEQNTGKFKSMV 244 T + ++ T+ + T +L P+ +T+P A NT S+ Sbjct: 198 FIISTSITTAPAATTAATSLAKTVNLSVTPSPA-------PRTLPAAPASTNTTATPSLT 250 Query: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304 P P P P + A + + P L P + + T+ T Sbjct: 251 HMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGI---PSTSVPT 307 Query: 305 LYSGTGL-----SVNRENAKCFTTKEELGKTVPQLLTPGL 339 L S + S RE + C E L P+ +P L Sbjct: 308 LESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPL 347 >gi|54144631 phosphatase and actin regulator 1 [Homo sapiens] Length = 580 Score = 270 bits (689), Expect = 3e-72 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%) Query: 351 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 405 E + ++E ++SD D LYT ++E+EDED+D S S+LA K+ R+D+LAIKL N Sbjct: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430 Query: 406 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 465 RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ Sbjct: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490 Query: 466 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 524 E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK Sbjct: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550 Query: 525 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 554 AAIRKELNEFKSTEMEVHE SR TRFHRP Sbjct: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580 Score = 110 bits (276), Expect = 3e-24 Identities = 51/96 (53%), Positives = 73/96 (76%), Gaps = 1/96 (1%) Query: 4 AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63 A + +++ + SD G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA LE Sbjct: 83 AAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAALE 141 Query: 64 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSN 99 RKIS RQSREELI+RGVLKE+ D+DG+++++ E + Sbjct: 142 RKISMRQSREELIKRGVLKEIYDKDGELSISNEEDS 177 Score = 33.1 bits (74), Expect = 0.68 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%) Query: 334 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 393 LL P LM SSE +D R + S SD P L E G+ E Sbjct: 41 LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92 Query: 394 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 449 R D+L P ++ + N+ + +++ E + L R++S R + EE Sbjct: 93 MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152 Query: 450 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 489 L +R +LK+ NEE+ E L S +LSL P ++E++ Sbjct: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198 >gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sapiens] Length = 448 Score = 224 bits (571), Expect = 2e-58 Identities = 120/208 (57%), Positives = 152/208 (73%), Gaps = 4/208 (1%) Query: 348 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRP 407 +A E E ++E +S+ +L DE+ D SG K ++ LA+KL NRP Sbjct: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK---KELLAVKLRNRP 300 Query: 408 SKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEA 467 SK+ELED+NI R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE Sbjct: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360 Query: 468 KMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAA 526 + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAA Sbjct: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420 Query: 527 IRKELNEFKSTEMEVHEESRQFTRFHRP 554 IRKELNE+KS EMEVH S+ TRFHRP Sbjct: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448 Score = 87.4 bits (215), Expect = 3e-17 Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 14/172 (8%) Query: 8 LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 67 +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++ Sbjct: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59 Query: 68 TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE------- 120 RQ REELI++G+L E+ +QD + + G E T + + SE+ Sbjct: 60 GRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPL 117 Query: 121 --GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKAS 170 G VS PL A AG + + + K SA PS S P S Sbjct: 118 ATGTDQVS-LDKPLSSAAHLDDAGQATLFQASSMK-SADPSLRGQLSTPTGS 167 >gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] Length = 2968 Score = 53.5 bits (127), Expect = 5e-07 Identities = 42/164 (25%), Positives = 68/164 (41%), Gaps = 10/164 (6%) Query: 106 GEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSS 165 G E+ EE K+ +G + A SS S ++ S +S+S S+SS+SS Sbjct: 2578 GSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSS 2637 Query: 166 RPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKL 225 +S + SS + + ++ + +S ++D +S +SD + PA T S Sbjct: 2638 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPS--A 2695 Query: 226 EQTVPGAEEQNTGKF--------KSMVPPPPVAPAPSPLAPPLP 261 + +P + GK K P P AP P P P P Sbjct: 2696 QAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQP 2739 Score = 49.3 bits (116), Expect = 9e-06 Identities = 52/187 (27%), Positives = 80/187 (42%), Gaps = 11/187 (5%) Query: 82 KELPDQDG--DVTVNFENSNGHMIPIGEESTREENVVKSEEG--NGSVSEKTPPLEEQAE 137 K +QDG + + +S+G S+ EEG NG T A Sbjct: 2546 KAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAA 2605 Query: 138 DKKAGS--SHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPI 195 +A S S S ++ S +S+S S+SS+SS +S + SS + + ++ + Sbjct: 2606 SSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2665 Query: 196 TSHLSS--DTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFK-SMVPPPPVAPA 252 +S SS D +S +SD + PA T S + +P + GK + S P PA Sbjct: 2666 SSSSSSTTDEDSSCSSDDEAAPAPTAGPS--AQAALPTKATKQAGKARPSAHSPGKKTPA 2723 Query: 253 PSPLAPP 259 P P APP Sbjct: 2724 PQPQAPP 2730 Score = 41.2 bits (95), Expect = 0.003 Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 11/188 (5%) Query: 78 RGVLKELPDQDGDVTVNFENSNGHMIPIGE-ESTREENVVKSEEGNGSVSEKTPPLEEQA 136 RG+L +L D +TV F++ + IP+ + ++ E + ++ + + Sbjct: 2248 RGLL-DLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRK 2306 Query: 137 EDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPIT 196 K G T GS+ + +R + K + +K T + TD+ P T Sbjct: 2307 TSKDTGEGKDGGTAGSEEPGA------KARGRGRKPSAKAKGDRAATLEEGNPTDEVPST 2360 Query: 197 SHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVA--PAPS 254 ++T G+ EP + R ++ K + P F S P P A PAP+ Sbjct: 2361 PLALEPSSTPGSKKSPPEPVDKRAKAPK-ARPAPPQPSPAPPAFTSCPAPEPFAELPAPA 2419 Query: 255 PLAPPLPL 262 P PL Sbjct: 2420 TSLAPAPL 2427 >gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sapiens] Length = 373 Score = 52.8 bits (125), Expect = 8e-07 Identities = 41/208 (19%), Positives = 91/208 (43%), Gaps = 23/208 (11%) Query: 354 GHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELE 413 GH+ +Q ++ D DG D++ED DED A + +R + S+ E Sbjct: 71 GHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQE 130 Query: 414 DKNILQ--------------RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNIL--- 456 ++ ++ +EER ++ + +L ++L +R EE E+R I+ Sbjct: 131 EQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE 190 Query: 457 ------KQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDR 510 ++KNE++ +E + ++ + + K + LQ + ++ E+++ ++ + +R Sbjct: 191 KHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECER 250 Query: 511 RADKPWARLTPADKAAIRKELNEFKSTE 538 + + + +KE+ E K E Sbjct: 251 KKKEKEKEKQQQAEIQEKKEIAEKKFQE 278 >gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2 [Homo sapiens] Length = 1320 Score = 52.4 bits (124), Expect = 1e-06 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 27/212 (12%) Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410 +DE EY ++ + + + E E E S + RRD L ++ N+ + Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368 Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 465 L + +LQ E++E ++Q+ + +R+ Q R E+ + +++ E E++ Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428 Query: 466 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 520 + E KRRL RK AE + RR+ R EY+ R+ ++ L Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR--------RQLEEEQRHLE 480 Query: 521 PADKAAIRKE--LNEFKSTEMEVHEESRQFTR 550 + ++++ L E + EME H ++ + R Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512 >gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sapiens] Length = 699 Score = 51.6 bits (122), Expect = 2e-06 Identities = 108/500 (21%), Positives = 179/500 (35%), Gaps = 105/500 (21%) Query: 10 KASIANSDGPTAGSQTPPFKRKGKLSTIGKIF------KPWKWRKKKTSDKFRETSAVLE 63 KA ++SD ++ PP +K K++ + KP + K + K +S+ Sbjct: 163 KAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSS 222 Query: 64 RKISTRQSREELIRRGVLKELPDQD-------GDVTVNFENSNGHMIPIGEESTREENVV 116 S+ S EE K +P + T S+ +E ++ + Sbjct: 223 SSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPM 282 Query: 117 KSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTT-------GSKASASPSTSSTSSRPKA 169 K++ G S PP K G+ KK S+ S+ S SS+ K Sbjct: 283 KNKPGPYS---SVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339 Query: 170 SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 229 + V SKA TTK K +S SSD+ +S + +PA Sbjct: 340 PTKAVVSKA----TTK-PPPAKKAAESSSDSSDSDSSEDDEAPSKPA------------- 381 Query: 230 PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 289 G + ++ K P V PA +P P V G L D Sbjct: 382 -GTTKNSSNKPAVTTKSPAVKPAAAPKQP------------------VGGGQKLLTRKAD 422 Query: 290 PSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSA 349 S +EE ++ +++EE K + P +++ S A Sbjct: 423 SSS---SEEESS--------------------SSEEEKTKKMVATTKPKATAKAALSLPA 459 Query: 350 SE-DEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPS 408 + +G R DS SD +D +E+E+ + +SA+ K ++ + G PS Sbjct: 460 KQAPQGSR-----DSSSD-----SDSSSSEEEEEKTSKSAVKKKPQK-----VAGGAAPS 504 Query: 409 KKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPT------TEELEQRNILKQKNEE 462 K K + ++ + ++ KL + S RP T L +N KN E Sbjct: 505 KPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSE 564 Query: 463 EEQEAKMELKRRLSRKLSLR 482 EE+E K + +S+ SL+ Sbjct: 565 EEEEEKKKAAVVVSKSGSLK 584 >gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo sapiens] Length = 1393 Score = 50.4 bits (119), Expect = 4e-06 Identities = 79/368 (21%), Positives = 131/368 (35%), Gaps = 38/368 (10%) Query: 47 RKKKTSDKFRETSAVLERKIST--------------RQSREELIRRGVLKELPDQDGDVT 92 R K +DK S ++ K ST Q ++ +IR + + D T Sbjct: 91 RHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQ--RSVDPADSTTT 148 Query: 93 VNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP----PLEEQAEDKKAGSSHSKK 148 H+ P + N KS G +V+ K+ PLE+ S+ S K Sbjct: 149 HKESAGKKHITPAPKSKI---NCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHK 205 Query: 149 TTGSKASASPSTSSTSSRPKASKETVSSKAG--TVGTTKGKRKTDKQPITSHLSSDTTTS 206 TT S ++ S + S K T +SK T GT + KT+ T+ S T Sbjct: 206 TTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSR-TTVASDKLLTK 264 Query: 207 GTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPP----VAPAPSPLAPPLPL 262 T +++ + + E T G N S P A + L+P P+ Sbjct: 265 TTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPI 324 Query: 263 EDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT--------NRTTLYSGTGLSVN 314 E++ TA++ + + + + L+ EPT TT Sbjct: 325 ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG 384 Query: 315 RENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374 A TT T TP +++ S + S + G R AN++ + P T++ Sbjct: 385 ERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTEN 444 Query: 375 EDEDEDED 382 + +E+ Sbjct: 445 RERTANEN 452 Score = 40.0 bits (92), Expect = 0.006 Identities = 71/320 (22%), Positives = 116/320 (36%), Gaps = 50/320 (15%) Query: 99 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASP 158 +G P+ E+T +E + +EKT P + + + +++ T S + Sbjct: 703 HGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANENTT----PSPAQ 758 Query: 159 STSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTT---------TSGTS 209 T + P A+++T S A T GKR T+ S++ T T+ Sbjct: 759 PTENGDRTPLANEKTTPSLAEP--TENGKRTPFANEKTTSSSAEPTEHAERTPLANENTT 816 Query: 210 DLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITA 269 EP E R + + T AE + + P P P E++ TA Sbjct: 817 SSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPF--------PAEPTENREWTA 868 Query: 270 SDTPVVLVSVGADLPVSALDPSQLLWAEEPT---NRTTLYSGTGLSVNRENAKCFTTKEE 326 ++ + L P++ EE T N T S + N E FT + Sbjct: 869 NEN-------------TTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTP-FTNE-- 912 Query: 327 LGKTVPQLLTPGLMGESS------ESFSASEDEGHREYQANDSDSDGPILYTDDEDEDED 380 KT P P GE + + S +E H E AN+ + P T+ + + Sbjct: 913 --KTTPSSAEPTEHGERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVN 970 Query: 381 EDGSGESALASKIRRRDTLA 400 ED + SA ++ R LA Sbjct: 971 EDTTPSSAEPTENGERTPLA 990 Score = 37.7 bits (86), Expect = 0.028 Identities = 65/287 (22%), Positives = 108/287 (37%), Gaps = 38/287 (13%) Query: 99 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS-KASAS 157 +G P+ E+T +E + +E T P AG + +++TT + K + S Sbjct: 423 HGERTPLANENTTPSPAEPTENRERTANENTTP-------SPAGPTENRETTANEKTTLS 475 Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG---------T 208 P + + A+++T S A T G+R T+ S++ T G T Sbjct: 476 PVEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTPLANENT 533 Query: 209 SDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCIT 268 + EP E R E E+T P E ++ + P+ LA P + Sbjct: 534 TPSPAEPTENR-ERTANEKTTPSPAEPTENGDRTPLANEKTTPS---LAEPTENGQRTPF 589 Query: 269 ASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRE-NAKCFTTKEEL 327 A++ S+ +P++ N T S + NRE A TT Sbjct: 590 ANEKTT----------SSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 639 Query: 328 GKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374 G T + +T E + F A E +RE AN+ + P T++ Sbjct: 640 GPTENREMT---ANEKTTLFPAEPTE-NRERTANEKTTSSPAEPTEN 682 Score = 37.4 bits (85), Expect = 0.036 Identities = 56/300 (18%), Positives = 112/300 (37%), Gaps = 34/300 (11%) Query: 108 ESTREENVVKSEEGNGSVSEKTPPLE-EQAEDKKAGSSHSKKTTGSKAS----------A 156 E T V +E + +EKT P E E+ + ++KTT S A A Sbjct: 470 EKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 529 Query: 157 SPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPA 216 + +T+ + + P ++E +++ T + D+ P+ + ++ + T + + P Sbjct: 530 NENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP- 588 Query: 217 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVL 276 F E+T + E + ++ + P+P A P ++ + TP Sbjct: 589 ------FANEKTTSSSAEPTEHEERTPLANENTTPSP---AEPTENRERTANENTTPS-- 637 Query: 277 VSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT 336 P + ++ E +TTL+ A TT T T Sbjct: 638 -------PAGPTENREMTANE----KTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 686 Query: 337 PGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR 396 P +++ S + + G R AN++ + P T++ + +E + A ++ R R Sbjct: 687 PFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRER 746 Score = 37.4 bits (85), Expect = 0.036 Identities = 47/198 (23%), Positives = 79/198 (39%), Gaps = 44/198 (22%) Query: 85 PDQDGDVTVNFENS--------NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPL-EEQ 135 P + G+ TVN + + NG P+ E+T +E G + +EKT P E Sbjct: 961 PTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTEHGERTANEKTTPSPAEP 1020 Query: 136 AEDKKAGSSHSKKTTGSKA----------SASPSTSSTSSRP--KASKETVSSKAGTV-- 181 E + S ++KT S A SA+ +T+ + +P K T++++ T+ Sbjct: 1021 TEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSP 1080 Query: 182 -GTTKGKRKTD--KQPITSHLSSDT-----TTSGTSDLKGEPAETRVESFKLEQTVPGAE 233 G T+ KT + IT L+ T TTS + AE+ E Sbjct: 1081 EGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAES-------------TE 1127 Query: 234 EQNTGKFKSMVPPPPVAP 251 ++ +++ P P P Sbjct: 1128 HRDRATSANVITPAPAEP 1145 Score = 29.3 bits (64), Expect = 9.9 Identities = 33/165 (20%), Positives = 53/165 (32%), Gaps = 27/165 (16%) Query: 105 IGEESTREENVVKSEEGNGSVSEKTPPL---------------EEQAEDKKAGSSHSKKT 149 I E +E G +V+E T P E + H ++T Sbjct: 949 IANEKATPSPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTEHGERT 1008 Query: 150 TGSKASASPS--TSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG 207 K + SP+ T P A+++T+ S A + T+ + +T + +TT S Sbjct: 1009 ANEKTTPSPAEPTEHGERTPSANEKTIPSPA---------KPTEHEEMTPSANENTTPSP 1059 Query: 208 TSDLK-GEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAP 251 + GE E L P T + P P Sbjct: 1060 VKPTEHGEKTTLANEKITLSPEGPTEHGAKTTSANEKITPSLAKP 1104 >gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] Length = 2817 Score = 50.1 bits (118), Expect = 5e-06 Identities = 104/553 (18%), Positives = 202/553 (36%), Gaps = 94/553 (16%) Query: 64 RKISTRQSREELIRRGVLKELPDQDGDVTVNFENS----NGHMIPIG------------E 107 +K + R + L + G+ + +P ++ EN N +++P E Sbjct: 34 QKTTARHGLQSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEE 93 Query: 108 ESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRP 167 E T E + + G + E P + A +K+ G + PS + + Sbjct: 94 EKTPEVPPAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQE 153 Query: 168 KASKETVSSKAG------------------TVGTTKGKRKTDKQPITSHLSSDTTTSGTS 209 K KET G G+ + +K P D +T+GTS Sbjct: 154 KKEKETNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLP-----GQDESTAGTS 208 Query: 210 DLKG--EPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPL--PLEDQ 265 + + E R+ + + G + ++++M+PP P PPL P+ Sbjct: 209 EQNDILKVVEKRIACGPPQAKLNGQQAALASQYRAMMPPYMFQQYPRMTYPPLHGPMR-- 266 Query: 266 CITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNR-ENAKCFTTK 324 P L L PS WA EP + L + +++ +N + Sbjct: 267 ------FPPSLSETNKGLRGRGPPPS---WASEPERPSILSASELKELDKFDNLDAEADE 317 Query: 325 EELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGS 384 G + T L +FS +++G + N+S+ G ++E++ E ++ S Sbjct: 318 GWAGAQMEVDYTEQL------NFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVS 371 Query: 385 GESALASKIRRRDTLAIKLGNRPSKKELE---------DKNILQRTSEEERQEI------ 429 + + + + G PS + K + Q+ +RQ + Sbjct: 372 NTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGP 431 Query: 430 ---RQQIGTK----LVRRLSQRPTTEELE----QRNILKQKNEEEEQEAKMELKRRLSRK 478 +QQ+ + RR Q + +E +R +++ EE+ + A E +RL K Sbjct: 432 FPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEK 491 Query: 479 LSL---RPTVAELQARRILRFNE-YVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEF 534 L + +P+ E++ R + E E+ + +R ++ R +K KEL + Sbjct: 492 LGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEK---EKELEKE 548 Query: 535 KSTEMEVHEESRQ 547 + + E+ +E +Q Sbjct: 549 QEKQREMEKERKQ 561 Score = 40.4 bits (93), Expect = 0.004 Identities = 40/154 (25%), Positives = 72/154 (46%), Gaps = 21/154 (13%) Query: 337 PGLMGE-SSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDE--DGSGESALASKI 393 PG G S+ A EDE ++ + S+ + E+E+ + ++A A K+ Sbjct: 426 PGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKL 485 Query: 394 RRRDTLAIKLGNRPS---------KKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQR 444 +R D L +PS +KE E + L++ E+ER++ R++ R Q+ Sbjct: 486 KRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREK------DRERQQ 539 Query: 445 PTTEELEQRNILKQKNEEEEQEAKMELKRRLSRK 478 +ELE+ ++K E E+E K E ++ L R+ Sbjct: 540 EKEKELEKE---QEKQREMEKERKQEKEKELERQ 570 Score = 31.2 bits (69), Expect = 2.6 Identities = 34/162 (20%), Positives = 63/162 (38%), Gaps = 19/162 (11%) Query: 107 EESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSR 166 +E +E +K +E + ++ LEE+ E ++ + S+ S + +R Sbjct: 571 KEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTR 630 Query: 167 PKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTS----------DLKGEPA 216 +++ S K T + + ++ QP + LS S +K + Sbjct: 631 QDSNR---SEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQW 687 Query: 217 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAP 258 + + + L QTVP +T VPPPP P P+ P Sbjct: 688 QQQQQQGVLPQTVPSQPSSST------VPPPPHRPLYQPMQP 723 Score = 30.0 bits (66), Expect = 5.8 Identities = 47/241 (19%), Positives = 90/241 (37%), Gaps = 40/241 (16%) Query: 85 PDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG-------SVSEKTPPLEEQAE 137 P ++ V + S + G T++ + +SE G + K P + + Sbjct: 907 PQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEK 966 Query: 138 DKKAGSSHS------KKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTD 191 KK G S +K SK+ +S+R + + ++G + Sbjct: 967 PKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPI---------- 1016 Query: 192 KQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAP 251 K+P+ + + + +GE AE E ++ + T K K + PPPP Sbjct: 1017 KKPVLRDMKEEREQR--KEKEGEKAEKVTEKVVVKP-------EKTEK-KDLPPPPPPPQ 1066 Query: 252 APSPLAP---PLPLEDQC----ITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304 P+P+ P P P++ + T + T S + P+ + Q+ A + N+ T Sbjct: 1067 PPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQT 1126 Query: 305 L 305 + Sbjct: 1127 M 1127 Score = 30.0 bits (66), Expect = 5.8 Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 7/126 (5%) Query: 172 ETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE------TRVESFKL 225 E VS K + +RK ++Q I + G S P T ++ + Sbjct: 1683 EVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGIQQAQS 1742 Query: 226 EQTVPG-AEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLP 284 +VP A + VP AP P+ L P + AS VL S A +P Sbjct: 1743 SASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVP 1802 Query: 285 VSALDP 290 S L P Sbjct: 1803 ASPLAP 1808 Score = 29.3 bits (64), Expect = 9.9 Identities = 31/111 (27%), Positives = 55/111 (49%), Gaps = 18/111 (16%) Query: 373 DDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQ 432 + E E E E + K R +D + + +KELE + QR E+ER++ +++ Sbjct: 510 EKEREREKELEKEQEQEREKEREKD----RERQQEKEKELEKEQEKQREMEKERKQEKEK 565 Query: 433 IGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKR-RLSRKLSLR 482 +L R Q+ +EL QK +E+E+E ++E +R +L K+ R Sbjct: 566 ---ELER---QKEKEKEL-------QKMKEQEKECELEKEREKLEEKIEPR 603 >gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical region 1 [Homo sapiens] Length = 1400 Score = 49.3 bits (116), Expect = 9e-06 Identities = 79/368 (21%), Positives = 130/368 (35%), Gaps = 38/368 (10%) Query: 47 RKKKTSDKFRETSAVLERKIST--------------RQSREELIRRGVLKELPDQDGDVT 92 R K +DK S ++ K ST Q ++ +IR + + D T Sbjct: 153 RHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQ--RSVDPADSTTT 210 Query: 93 VNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP----PLEEQAEDKKAGSSHSKK 148 H+ P + N KS G +V+ K+ PLE+ S+ S K Sbjct: 211 HKESAGKKHITPAPKSKI---NCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHK 267 Query: 149 TTGSKASASPSTSSTSSRPKASKETVSSKAG--TVGTTKGKRKTDKQPITSHLSSDTTTS 206 TT S ++ S + S K T +SK T GT + KT+ T+ S T Sbjct: 268 TTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSR-TTVASDKLLTK 326 Query: 207 GTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPP----VAPAPSPLAPPLPL 262 T +++ + + E T G N S P A + L+P P Sbjct: 327 TTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPT 386 Query: 263 EDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT--------NRTTLYSGTGLSVN 314 E++ TA++ + + + + L+ EPT TT Sbjct: 387 ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG 446 Query: 315 RENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374 A TT T TP +++ S + S + G R AN++ + P T++ Sbjct: 447 ERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTEN 506 Query: 375 EDEDEDED 382 + +E+ Sbjct: 507 RERTANEN 514 Score = 37.7 bits (86), Expect = 0.028 Identities = 65/287 (22%), Positives = 108/287 (37%), Gaps = 38/287 (13%) Query: 99 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS-KASAS 157 +G P+ E+T +E + +E T P AG + +++TT + K + S Sbjct: 485 HGERTPLANENTTPSPAEPTENRERTANENTTP-------SPAGPTENRETTANEKTTLS 537 Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG---------T 208 P + + A+++T S A T G+R T+ S++ T G T Sbjct: 538 PVEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTPLANENT 595 Query: 209 SDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCIT 268 + EP E R E E+T P E ++ + P+ LA P + Sbjct: 596 TPSPAEPTENR-ERTANEKTTPSPAEPTENGDRTPLANEKTTPS---LAEPTENGQRTPF 651 Query: 269 ASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRE-NAKCFTTKEEL 327 A++ S+ +P++ N T S + NRE A TT Sbjct: 652 ANEKTT----------SSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 701 Query: 328 GKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374 G T + +T E + F A E +RE AN+ + P T++ Sbjct: 702 GPTENREMT---ANEKTTLFPAEPTE-NRERTANEKTTSSPAEPTEN 744 Score = 37.0 bits (84), Expect = 0.047 Identities = 56/300 (18%), Positives = 112/300 (37%), Gaps = 34/300 (11%) Query: 108 ESTREENVVKSEEGNGSVSEKTPPLE-EQAEDKKAGSSHSKKTTGSKAS----------A 156 E T V +E + +EKT P E E+ + ++KTT S A A Sbjct: 532 EKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 591 Query: 157 SPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPA 216 + +T+ + + P ++E +++ T + D+ P+ + ++ + T + + P Sbjct: 592 NENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP- 650 Query: 217 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVL 276 F E+T + E + ++ + P+P A P ++ + TP Sbjct: 651 ------FANEKTTSSSAEPTEHEERTPLANENTTPSP---AEPTENRERTANENTTPS-- 699 Query: 277 VSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT 336 P + ++ E +TTL+ A TT T T Sbjct: 700 -------PAGPTENREMTANE----KTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 748 Query: 337 PGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR 396 P +++ S + + G R AN++ + P T++ + +E + A ++ R R Sbjct: 749 PFANEKTTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRER 808 Score = 32.3 bits (72), Expect = 1.2 Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 26/190 (13%) Query: 99 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASP 158 +G P+ E+T +E + +EKT P + + + +++ T S + Sbjct: 765 HGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRERTANENTT----PSPAQ 820 Query: 159 STSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTT---------TSGTS 209 T + P A+++T S A T GKR T+ S++ T T+ Sbjct: 821 PTENGDRTPLANEKTTPSLAEP--TENGKRTPFANEKTTSSSAEPTEHAERTPLANENTT 878 Query: 210 DLKGEPAETRVESFKLEQTVPGAE--EQNTGKFKSMVPPPPVAPAP---------SPLAP 258 EP E R + + T AE E P P P + L+P Sbjct: 879 SSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSP 938 Query: 259 PLPLEDQCIT 268 P E + +T Sbjct: 939 AEPTEHEEMT 948 Score = 31.6 bits (70), Expect = 2.0 Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 4/111 (3%) Query: 118 SEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSK 177 ++ ++S K ++ A + ++ TT S P+T+ST+ TVSS Sbjct: 1197 TDSATTAISTKASGTTVESAPSTAPPTPAETTTASV----PTTTSTTGSENTGHHTVSSV 1252 Query: 178 AGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQT 228 TV T + T + + S+ T+ + +ET V S K T Sbjct: 1253 PTTVFATASESSTGSETTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVT 1303 Score = 31.6 bits (70), Expect = 2.0 Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 8/131 (6%) Query: 141 AGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLS 200 A ++ S K +G+ ++PST+ P ET ++ T +T G T ++S + Sbjct: 1200 ATTAISTKASGTTVESAPSTA-----PPTPAETTTASVPTTTSTTGSENTGHHTVSSVPT 1254 Query: 201 SDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMV-PPPPVAPAPSPLAPP 259 + T+ S E TR + E T TG ++V PV S + Sbjct: 1255 TVFATASESSTGSE--TTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVTTTQSGFSTA 1312 Query: 260 LPLEDQCITAS 270 + + TAS Sbjct: 1313 TVMPAKTTTAS 1323 Score = 30.4 bits (67), Expect = 4.4 Identities = 57/238 (23%), Positives = 89/238 (37%), Gaps = 32/238 (13%) Query: 124 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 183 +VSE E A ++ S TT S ++ P+T+STS + + T+ Sbjct: 1035 AVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKNTTACEATMSETTIAA 1094 Query: 184 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 243 T TS +++++ + P +T S + TVP + NT + Sbjct: 1095 ITASEDTTVSTQTSVIAAESVPHTATK---TPTDTTTAS--VSATVP---KNNTLSVITS 1146 Query: 244 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWA--EEPTN 301 P + AP+ + + TAS T S LP + + + A E PT Sbjct: 1147 TP----STAPNTASKTM------TTASKT--TTTSTITSLPTTVFTTTSKITAGSEIPTA 1194 Query: 302 RTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESS----ESFSASEDEGH 355 TT + T +S TT E T P TP +S S + SE+ GH Sbjct: 1195 STTDSATTAISTKASG----TTVESAPSTAPP--TPAETTTASVPTTTSTTGSENTGH 1246 >gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3 [Homo sapiens] Length = 1212 Score = 49.3 bits (116), Expect = 9e-06 Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 17/160 (10%) Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410 +DE EY ++ + + + E E E S + RRD L ++ N+ + Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368 Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 465 L + +LQ E++E ++Q+ + +R+ Q R E+ + +++ E E++ Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428 Query: 466 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYV 500 + E KRRL RK AE + RR+ R EY+ Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468 >gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1 [Homo sapiens] Length = 1166 Score = 49.3 bits (116), Expect = 9e-06 Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 17/160 (10%) Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410 +DE EY ++ + + + E E E S + RRD L ++ N+ + Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368 Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 465 L + +LQ E++E ++Q+ + +R+ Q R E+ + +++ E E++ Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428 Query: 466 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYV 500 + E KRRL RK AE + RR+ R EY+ Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468 >gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens] Length = 1426 Score = 47.4 bits (111), Expect = 3e-05 Identities = 58/259 (22%), Positives = 105/259 (40%), Gaps = 32/259 (12%) Query: 139 KKAGSSHSKKT-TGSKASASPSTSSTSSRPKASKETVSSKA---------------GTVG 182 K S H+ + T S A+A S++ + + A++ T + K Sbjct: 132 KSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEA 191 Query: 183 TTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQT--VPGAEEQNTGKF 240 KG+ +T ++S++ T T+ L + + R + L Q P ++QN+ + Sbjct: 192 VLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQN 251 Query: 241 KSMVPPPPV-APAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEP 299 + P PP+ APAP P APP PL+ + + ++ SVG+ + L P P Sbjct: 252 TRLQPTPPIPAPAPKPAAPPRPLDRESPGVENK--LIPSVGSPASSTPLPPDGTGPNSTP 309 Query: 300 TNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT--PGLMGESSESFSASEDEGHRE 357 NR G + + + K P + + P +GE+ + S + E HRE Sbjct: 310 NNRAVTPVSQGSNSSSADPK--------APPPPPVSSGEPPTLGENPDGLSQEQLE-HRE 360 Query: 358 YQANDSDSDGPILYTDDED 376 +L+ D+++ Sbjct: 361 RSLQTLRDIQRMLFPDEKE 379 >gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] Length = 1564 Score = 46.6 bits (109), Expect = 6e-05 Identities = 107/496 (21%), Positives = 176/496 (35%), Gaps = 70/496 (14%) Query: 48 KKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGE 107 K + DK RE + +LE S+R +++I + D++ + EN I Sbjct: 913 KVSSVDKQREQTEILE---SSRMRAQDIIGH---HQSEDRETSDRAHDENKKKAKIQKKP 966 Query: 108 ESTREENVVKSEEGN-GSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSR 166 ++E+ V E GN + SE + KK +K + + S ++ S+ Sbjct: 967 IKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSK 1026 Query: 167 PKASKET--VSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFK 224 K T +++K V GK + S DT S SD E R E + Sbjct: 1027 KKRGPRTPPITTKEELVEMCNGKNGILED---SQKKEDTAFSDWSD---EDVPDRTEVTE 1080 Query: 225 LEQTVPGAEEQNTGKFKSMV--PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGAD 282 E T +T S + PPPPVA A TA+ P L + A Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATA---------------TATTVPATLAATTAA 1125 Query: 283 LPVS-ALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMG 341 S + + + PTN T + + KC T+ E +T P + Sbjct: 1126 AATSFSTSAITISTSATPTNTTN----NTFANEDSHRKCHRTRVEKVET-PHVTIEDAQH 1180 Query: 342 ESSESFSASEDEGHREYQANDSDSDGPILY--TDDEDEDEDEDGSGESALASKIRRRD-T 398 S G ++N S + G + D D+ + L S R R+ T Sbjct: 1181 RKPMDQKRSSSLGSN--RSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKT 1238 Query: 399 LAIKL-GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILK 457 ++++ G R S+ + + R++ +RQ+ R R S + ++ R+ Sbjct: 1239 KSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS-----RRSSPESDRQVHSRSGSF 1293 Query: 458 QKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWA 517 + ++ + E R R+ RR R E+ DR ADK W Sbjct: 1294 DSRDRLQERDRYEHDRERERE------------RRDTRQREW---------DRDADKDWP 1332 Query: 518 RLTPADKAAIRKELNE 533 R D+ R+ E Sbjct: 1333 RNRDRDRLRERERERE 1348 Score = 37.7 bits (86), Expect = 0.028 Identities = 35/173 (20%), Positives = 74/173 (42%), Gaps = 13/173 (7%) Query: 38 GKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFEN 97 G++F P K +KKK+ +K R+ S + IS ++ ++ ++ + P + V N Sbjct: 989 GQVFSPKKGQKKKSIEKKRKKSKG-DSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCN 1047 Query: 98 SNGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 157 ++ E+S ++E+ S+ + V ++T E + H+ T ++ S Sbjct: 1048 GKNGIL---EDSQKKEDTAFSDWSDEDVPDRTEVTE---------AEHTATATTPGSTPS 1095 Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSD 210 P +S P + T ++ T+ T T +S+ T + T++ Sbjct: 1096 PLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTN 1148 Score = 31.2 bits (69), Expect = 2.6 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 17/149 (11%) Query: 47 RKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNF----------E 96 RK+ + + RE + K T +S EE + ++ D +GD+ ++ + Sbjct: 113 RKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSD-NGDINYDYVHELSLEMKRQ 171 Query: 97 NSNGHMIPIGEEST--REENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKA 154 ++ + +E+ REE ++K E V K P + K+ S + S + Sbjct: 172 KIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSAS 231 Query: 155 SASPSTSSTSS----RPKASKETVSSKAG 179 TS+ SS + + SK S K G Sbjct: 232 KKDRKTSAVSSPLLDQQRNSKTNQSKKKG 260 Score = 31.2 bits (69), Expect = 2.6 Identities = 42/201 (20%), Positives = 78/201 (38%), Gaps = 29/201 (14%) Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410 E + RE + D D + D + + D E + R RD R ++ Sbjct: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERER---ERERERDR------EREKER 705 Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKME 470 ELE + +R E E++ R++ + R +R + E+ +++ E E+E + E Sbjct: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERE 765 Query: 471 LKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKE 530 +R R+ + R R E D D D+ D D+ R+E Sbjct: 766 RERERERE----------RERARERDKERERQRDWEDKDKGRD---------DRREKREE 806 Query: 531 LNEFKSTEMEVHEESRQFTRF 551 + E ++ + H+E + R+ Sbjct: 807 IREDRNPR-DGHDERKSKKRY 826 >gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sapiens] Length = 1323 Score = 46.2 bits (108), Expect = 8e-05 Identities = 42/191 (21%), Positives = 85/191 (44%), Gaps = 31/191 (16%) Query: 371 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 424 Y+ E+E+E+ D S++ + RRD L ++L N+ + L + + QR +EE Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382 Query: 425 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 471 ++++ + ++ + QR EE EQR +++ EE+ + E Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442 Query: 472 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 522 ++ RK AE R++ + +Y+ S + R+ +P + ++P+ Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499 Query: 523 DKAAIRKELNE 533 +K A KE+ E Sbjct: 500 EKPAWAKEVEE 510 >gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sapiens] Length = 1331 Score = 46.2 bits (108), Expect = 8e-05 Identities = 42/191 (21%), Positives = 85/191 (44%), Gaps = 31/191 (16%) Query: 371 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 424 Y+ E+E+E+ D S++ + RRD L ++L N+ + L + + QR +EE Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382 Query: 425 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 471 ++++ + ++ + QR EE EQR +++ EE+ + E Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442 Query: 472 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 522 ++ RK AE R++ + +Y+ S + R+ +P + ++P+ Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499 Query: 523 DKAAIRKELNE 533 +K A KE+ E Sbjct: 500 EKPAWAKEVEE 510 >gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens] Length = 490 Score = 46.2 bits (108), Expect = 8e-05 Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 15/194 (7%) Query: 13 IANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSR 72 ++N D T S K++ + + F+ K RKKK R+T++VL + +S Sbjct: 268 VSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQA-RKTASVLSKDDVAPESG 326 Query: 73 EELIRRGVLK--ELPDQD------GDVTVNFENSNG----HMIPIGEESTREENVVKSEE 120 + +++ K + P+ G V N + ++PIG+++ E V + Sbjct: 327 DTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKH 386 Query: 121 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 180 G S P KK + + +T + S +P S +PK +E V K+ + Sbjct: 387 ATGKKSPAKSPNPSTPRGKKRKALPASETPKAAESETPG-KSPEKKPKIKEEAVKEKSPS 445 Query: 181 VGTTKGKRKTDKQP 194 +G K R+T K+P Sbjct: 446 LG-KKDARQTPKKP 458 >gi|92859701 myosin VI [Homo sapiens] Length = 1285 Score = 46.2 bits (108), Expect = 8e-05 Identities = 52/224 (23%), Positives = 103/224 (45%), Gaps = 40/224 (17%) Query: 324 KEELGKTVPQL-LTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDED 382 K E+ K + L ++ + +S ++++ +EY A S+ + + + E+E Sbjct: 864 KPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEE- 922 Query: 383 GSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLS 442 A ++RR + ++ ++E ++K +R EEE + ++ ++ K + Sbjct: 923 -------AERLRR---IQEEMEKERKRREEDEK---RRRKEEEERRMKLEMEAKRKQEEE 969 Query: 443 QRPTTEELEQR-------NILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILR 495 +R E+ E+R + +QK EE +Q+A +E +RR R+L+LR +E + Sbjct: 970 ERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERR-DRELALRIAQSEAEL----- 1023 Query: 496 FNEYVEVTDSPDYD---RRADKPWARLTPADKAAIRKELNEFKS 536 ++D D RR D ++TP A KE++EF S Sbjct: 1024 ------ISDEAQADLALRRNDGTRPKMTPEQMA---KEMSEFLS 1058 >gi|195976782 Paf1/RNA polymerase II complex component [Homo sapiens] Length = 710 Score = 46.2 bits (108), Expect = 8e-05 Identities = 47/196 (23%), Positives = 84/196 (42%), Gaps = 12/196 (6%) Query: 314 NRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTD 373 N+ K K E T+ + SS+ S++E E + +DSDS+ +D Sbjct: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSD 168 Query: 374 DEDEDEDE---DGSGESALASK--IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQE 428 + EDE DG GE + + R + + K + +E + +L+R R E Sbjct: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKR-----RFE 223 Query: 429 IRQQIGT-KLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLR-PTVA 486 I++++ T K + ++ EE +++ L Q E + E + + KL + + Sbjct: 224 IKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283 Query: 487 ELQARRILRFNEYVEV 502 EL+A R R N E+ Sbjct: 284 ELKAEREKRKNRTAEL 299 >gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo sapiens] Length = 229 Score = 45.8 bits (107), Expect = 1e-04 Identities = 32/135 (23%), Positives = 60/135 (44%), Gaps = 14/135 (10%) Query: 354 GHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELE 413 GH+ +Q ++ D DG D++ED DED A + +R + S+ E Sbjct: 71 GHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQE 130 Query: 414 DKNILQ--------------RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQK 459 ++ ++ +EER ++ + +L ++L +R EE E+R I+ ++ Sbjct: 131 EQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE 190 Query: 460 NEEEEQEAKMELKRR 474 +E + K E RR Sbjct: 191 KHKEWVQKKNEQVRR 205 >gi|118498337 HECT domain containing 1 [Homo sapiens] Length = 2610 Score = 45.4 bits (106), Expect = 1e-04 Identities = 71/314 (22%), Positives = 122/314 (38%), Gaps = 47/314 (14%) Query: 113 ENVVKSEEGNGS---VSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKA 169 ENV ++E G+ S S T + ++K G S +T G ++ S S SS + Sbjct: 1433 ENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVS 1492 Query: 170 SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 229 S V K ++P++S S+ + S G P + +V Sbjct: 1493 S----------VSELTNKEAASQRPLSSSASNRLSVSSLL-AAGAPMSSSA-------SV 1534 Query: 230 PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 289 P + T +S V + +A + ++ S + ++G ++ +A Sbjct: 1535 PNLSSRETSSLESFVR------RVANIARTNATNNMNLSRSSSDNNTNTLGRNVMSTATS 1588 Query: 290 PSQLLWAEE------PTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 343 P L+ A+ P +T+ T + N TT +G+++ LT L S Sbjct: 1589 P--LMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTS 1646 Query: 344 SESFSASEDEGHREYQANDS----------DSDGPILYTDDED-EDEDEDGSGESALASK 392 SES + E E + Y DS D D + D+ED E+ED++ + Sbjct: 1647 SESDTGQEAE-YSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVM 1705 Query: 393 IRRRDTLAIKLGNR 406 I RR +L + G+R Sbjct: 1706 ILRRPSLQRRAGSR 1719 >gi|145580582 uromodulin-like 1 isoform 2 precursor [Homo sapiens] Length = 1446 Score = 45.1 bits (105), Expect = 2e-04 Identities = 44/171 (25%), Positives = 66/171 (38%), Gaps = 22/171 (12%) Query: 78 RGVLKELP--------DQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKT 129 +GV +E+P DQ VN + + +EST + + + GS S+ Sbjct: 628 KGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVN 687 Query: 130 PPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRK 189 P Q A SS + GS + SPS STS + + T+ G +GTT + Sbjct: 688 P---SQRSTSHANSSQGSPSQGSPSQESPSQGSTSQASPSHRNTI----GVIGTTSSPKA 740 Query: 190 TDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 240 T ++H T G L P + + S + P E TG F Sbjct: 741 TG----STHSFPPGATDGPLAL---PGQLQGNSIMEPPSWPSPTEDPTGHF 784 >gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sapiens] Length = 1268 Score = 44.7 bits (104), Expect = 2e-04 Identities = 41/189 (21%), Positives = 84/189 (44%), Gaps = 31/189 (16%) Query: 371 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 424 Y+ E+E+E+ D S++ + RRD L ++L N+ + L + + QR +EE Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382 Query: 425 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 471 ++++ + ++ + QR EE EQR +++ EE+ + E Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442 Query: 472 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 522 ++ RK AE R++ + +Y+ S + R+ +P + ++P+ Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499 Query: 523 DKAAIRKEL 531 +K A KE+ Sbjct: 500 EKPAWAKEI 508 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.305 0.124 0.338 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,737,727 Number of Sequences: 37866 Number of extensions: 1219457 Number of successful extensions: 15291 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 254 Number of HSP's successfully gapped in prelim test: 913 Number of HSP's that attempted gapping in prelim test: 9643 Number of HSP's gapped (non-prelim): 4711 length of query: 554 length of database: 18,247,518 effective HSP length: 107 effective length of query: 447 effective length of database: 14,195,856 effective search space: 6345547632 effective search space used: 6345547632 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 43 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.