Search of human proteins with 154354972

Search of human proteins with 154354972

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo
sapiens]
         (554 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo s...  1090   0.0  
gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo s...  1083   0.0  
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s...   954   0.0  
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s...   946   0.0  
gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa...   292   5e-79
gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa...   291   1e-78
gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo s...   279   4e-75
gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo s...   279   4e-75
gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]          270   3e-72
gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sa...   224   2e-58
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         54   5e-07
gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sap...    53   8e-07
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    52   1e-06
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    52   2e-06
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    50   4e-06
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             50   5e-06
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    49   9e-06
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    49   9e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    49   9e-06
gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]                       47   3e-05
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        47   6e-05
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...    46   8e-05
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...    46   8e-05
gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens]           46   8e-05
gi|92859701 myosin VI [Homo sapiens]                                   46   8e-05
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi...    46   8e-05
gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo sap...    46   1e-04
gi|118498337 HECT domain containing 1 [Homo sapiens]                   45   1e-04
gi|145580582 uromodulin-like 1 isoform 2 precursor [Homo sapiens]      45   2e-04
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...    45   2e-04

>gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo
           sapiens]
          Length = 554

 Score = 1090 bits (2820), Expect = 0.0
 Identities = 554/554 (100%), Positives = 554/554 (100%)

Query: 1   MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60
           MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA
Sbjct: 1   MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60

Query: 61  VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120
           VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE
Sbjct: 61  VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120

Query: 121 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 180
           GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT
Sbjct: 121 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 180

Query: 181 VGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 240
           VGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF
Sbjct: 181 VGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 240

Query: 241 KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT 300
           KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT
Sbjct: 241 KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT 300

Query: 301 NRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360
           NRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA
Sbjct: 301 NRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360

Query: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQR 420
           NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQR
Sbjct: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQR 420

Query: 421 TSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLS 480
           TSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLS
Sbjct: 421 TSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLS 480

Query: 481 LRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEME 540
           LRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEME
Sbjct: 481 LRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEME 540

Query: 541 VHEESRQFTRFHRP 554
           VHEESRQFTRFHRP
Sbjct: 541 VHEESRQFTRFHRP 554


>gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo
           sapiens]
          Length = 565

 Score = 1083 bits (2800), Expect = 0.0
 Identities = 550/551 (99%), Positives = 551/551 (100%)

Query: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63
           +VDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE
Sbjct: 15  SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 74

Query: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123
           RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG
Sbjct: 75  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 134

Query: 124 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 183
           SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT
Sbjct: 135 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 194

Query: 184 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 243
           TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM
Sbjct: 195 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 254

Query: 244 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT 303
           VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT
Sbjct: 255 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT 314

Query: 304 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS 363
           TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS
Sbjct: 315 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS 374

Query: 364 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE 423
           DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE
Sbjct: 375 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE 434

Query: 424 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP 483
           EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP
Sbjct: 435 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP 494

Query: 484 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE 543
           TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE
Sbjct: 495 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE 554

Query: 544 ESRQFTRFHRP 554
           ESRQFTRFHRP
Sbjct: 555 ESRQFTRFHRP 565


>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
           sapiens]
          Length = 634

 Score =  954 bits (2466), Expect = 0.0
 Identities = 510/634 (80%), Positives = 525/634 (82%), Gaps = 80/634 (12%)

Query: 1   MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60
           MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA
Sbjct: 1   MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSA 60

Query: 61  VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120
           VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE
Sbjct: 61  VLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE 120

Query: 121 GNGSVSEKTPPLEEQAEDKK---------------------------------------- 140
           GNGSVSEKTPPLEEQAEDKK                                        
Sbjct: 121 GNGSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGAT 180

Query: 141 AGSSH----------SKKTTGSKA------SASPSTSSTSSRPKASKETVSSKAG---TV 181
           AG+SH          + K  G +A       AS +T+  ++    SK+T  SKA    + 
Sbjct: 181 AGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPST 240

Query: 182 GTTKGKRKTDKQPITSHLSSDTTTSG---------------------TSDLKGEPAETRV 220
            +T  + K  K+ ++S   +  TT G                     TSDLKGEPAETRV
Sbjct: 241 SSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRV 300

Query: 221 ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG 280
           ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG
Sbjct: 301 ESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVG 360

Query: 281 ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM 340
           ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM
Sbjct: 361 ADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLM 420

Query: 341 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA 400
           GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA
Sbjct: 421 GESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLA 480

Query: 401 IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKN 460
           IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKN
Sbjct: 481 IKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKN 540

Query: 461 EEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 520
           EEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT
Sbjct: 541 EEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 600

Query: 521 PADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554
           PADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP
Sbjct: 601 PADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 634


>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
           sapiens]
          Length = 645

 Score =  946 bits (2446), Expect = 0.0
 Identities = 506/631 (80%), Positives = 522/631 (82%), Gaps = 80/631 (12%)

Query: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63
           +VDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE
Sbjct: 15  SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 74

Query: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123
           RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG
Sbjct: 75  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 134

Query: 124 SVSEKTPPLEEQAEDKK----------------------------------------AGS 143
           SVSEKTPPLEEQAEDKK                                        AG+
Sbjct: 135 SVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGA 194

Query: 144 SH----------SKKTTGSKA------SASPSTSSTSSRPKASKETVSSKAG---TVGTT 184
           SH          + K  G +A       AS +T+  ++    SK+T  SKA    +  +T
Sbjct: 195 SHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSST 254

Query: 185 KGKRKTDKQPITSHLSSDTTTSG---------------------TSDLKGEPAETRVESF 223
             + K  K+ ++S   +  TT G                     TSDLKGEPAETRVESF
Sbjct: 255 SSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESF 314

Query: 224 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL 283
           KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL
Sbjct: 315 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL 374

Query: 284 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 343
           PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES
Sbjct: 375 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 434

Query: 344 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL 403
           SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL
Sbjct: 435 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL 494

Query: 404 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE 463
           GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE
Sbjct: 495 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE 554

Query: 464 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD 523
           EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD
Sbjct: 555 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD 614

Query: 524 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554
           KAAIRKELNEFKSTEMEVHEESRQFTRFHRP
Sbjct: 615 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 645


>gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
           sapiens]
          Length = 559

 Score =  292 bits (748), Expect = 5e-79
 Identities = 203/558 (36%), Positives = 295/558 (52%), Gaps = 47/558 (8%)

Query: 6   DGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERK 65
           D +D+   A  +   +G +TPP +R  KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K
Sbjct: 40  DEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKK 98

Query: 66  ISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSV 125
           ++ RQ REELI++G+L E+ +QD +      +     +     + + E +   +   GS 
Sbjct: 99  MAGRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGS- 156

Query: 126 SEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185
                PL    +        S       A+  PS SS             + AG++    
Sbjct: 157 -----PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE----------ADAGSL---- 197

Query: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMV 244
                   P T+ LS     + + D    P E  V        +P    + + K  K++ 
Sbjct: 198 -------LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVT 250

Query: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304
               +  A S  +    L  Q  T + +P  L +V   LP S +   +L  A    +R  
Sbjct: 251 GQATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQD 308

Query: 305 LYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360
            + G    G    R + +   T   E GK   +  +     E+  + +   +E       
Sbjct: 309 SFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLII 368

Query: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNI 417
           N    D  +LY       +DE+   +S ++  + R+   + LA+KL NRPSK+ELED+NI
Sbjct: 369 NSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNI 421

Query: 418 LQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSR 477
             R ++EERQEIRQQI  KL +RLSQRP  EELE+RNILKQ+N++ EQE + E+K+RL+R
Sbjct: 422 FPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTR 481

Query: 478 KLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKS 536
           KL+ RPTV EL+ R+IL RF++YVEV  + DYDRRADKPW RL+ ADKAAIRKELNE+KS
Sbjct: 482 KLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKS 541

Query: 537 TEMEVHEESRQFTRFHRP 554
            EMEVH  S+  TRFHRP
Sbjct: 542 NEMEVHASSKHLTRFHRP 559


>gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo
           sapiens]
          Length = 518

 Score =  291 bits (744), Expect = 1e-78
 Identities = 202/556 (36%), Positives = 294/556 (52%), Gaps = 47/556 (8%)

Query: 8   LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 67
           +D+   A  +   +G +TPP +R  KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 1   MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59

Query: 68  TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSE 127
            RQ REELI++G+L E+ +QD +      +     +     + + E +   +   GS   
Sbjct: 60  GRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGS--- 115

Query: 128 KTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGK 187
              PL    +        S       A+  PS SS             + AG++      
Sbjct: 116 ---PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE----------ADAGSL------ 156

Query: 188 RKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMVPP 246
                 P T+ LS     + + D    P E  V        +P    + + K  K++   
Sbjct: 157 -----LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQ 211

Query: 247 PPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLY 306
             +  A S  +    L  Q  T + +P  L +V   LP S +   +L  A    +R   +
Sbjct: 212 ATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQDSF 269

Query: 307 SGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQAND 362
            G    G    R + +   T   E GK   +  +     E+  + +   +E       N 
Sbjct: 270 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 329

Query: 363 SDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNILQ 419
              D  +LY       +DE+   +S ++  + R+   + LA+KL NRPSK+ELED+NI  
Sbjct: 330 ELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 382

Query: 420 RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKL 479
           R ++EERQEIRQQI  KL +RLSQRP  EELE+RNILKQ+N++ EQE + E+K+RL+RKL
Sbjct: 383 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 442

Query: 480 SLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTE 538
           + RPTV EL+ R+IL RF++YVEV  + DYDRRADKPW RL+ ADKAAIRKELNE+KS E
Sbjct: 443 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 502

Query: 539 MEVHEESRQFTRFHRP 554
           MEVH  S+  TRFHRP
Sbjct: 503 MEVHASSKHLTRFHRP 518


>gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo
           sapiens]
          Length = 712

 Score =  279 bits (714), Expect = 4e-75
 Identities = 192/462 (41%), Positives = 258/462 (55%), Gaps = 29/462 (6%)

Query: 103 IPIGEESTREENVVKSE-----EGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 157
           IP  + + R  N V +E          +S+ +PPL      K+   S S  T  S A+ +
Sbjct: 270 IPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPP----KRGIPSTSVPTLESAAAIT 325

Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE 217
             T      P   +E  +   G+        ++   P+ +H+  +   +     K     
Sbjct: 326 TKT------PSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVV 379

Query: 218 TRVE---SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 274
             +E   S  L Q +P  E+Q     K ++      P      PPLPL  +   A  +P+
Sbjct: 380 PEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPL 439

Query: 275 VLVSV--GADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVP 332
            +  +  G+    S L  +   ++E+ +   TL     L +  E  K    +EE  +T P
Sbjct: 440 PMTPILEGSHRAHSLLFENSDSFSEDSS---TLGRTRSLPITIEMLKVPDDEEEEEQTCP 496

Query: 333 QLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASK 392
              +   M  +S      +     E + +DSDS+GPI Y D+EDEDE    S +SALA+K
Sbjct: 497 STFSEE-MTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDE----SYQSALANK 551

Query: 393 IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQ 452
           ++R+DTLA+KL +RPS+ EL + N     S+EE  EIR QIG  L+RRLSQRPT EELEQ
Sbjct: 552 VKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ 610

Query: 453 RNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRA 512
           RNIL+ KNE + Q  K E+KRRL+RKLS RPTVAEL AR+ILRFNEYVEVTD+ DYDRRA
Sbjct: 611 RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA 670

Query: 513 DKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554
           DKPW +LTPADKAAIRKELNEFKS+EMEVHEES+ FTR+HRP
Sbjct: 671 DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 712



 Score =  126 bits (316), Expect = 6e-29
 Identities = 106/340 (31%), Positives = 151/340 (44%), Gaps = 29/340 (8%)

Query: 17  DGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELI 76
           D   AG  TPP KRK K S  GKIFKPWKWRKKK+SDKF+ETS VLERKIS R+ REEL+
Sbjct: 30  DSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELV 89

Query: 77  RRGVLKELPDQDGDVTVNFENS---NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLE 133
           +RGVL E P+Q G+      ++   NGH  PIG  + R  + V+ EE    ++     + 
Sbjct: 90  KRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIG--NARSSSPVQVEEEPVRLASLRKAIP 147

Query: 134 EQAEDKKAGSSHSKKTTGS--------KASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185
           E+   K+ GS+ S+  + +        K    P     SS  +AS+        + GT +
Sbjct: 148 EEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTAR 207

Query: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA-EEQNTGKFKSMV 244
               T      +  ++ T+ + T +L   P+          +T+P A    NT    S+ 
Sbjct: 208 FIISTSITTAPAATTAATSLAKTVNLSVTPSPA-------PRTLPAAPASTNTTATPSLT 260

Query: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304
              P    P P   P       + A  +  +        P   L P + +     T+  T
Sbjct: 261 HMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGI---PSTSVPT 317

Query: 305 LYSGTGL-----SVNRENAKCFTTKEELGKTVPQLLTPGL 339
           L S   +     S  RE + C    E L    P+  +P L
Sbjct: 318 LESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPL 357


>gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo
           sapiens]
          Length = 702

 Score =  279 bits (714), Expect = 4e-75
 Identities = 192/462 (41%), Positives = 258/462 (55%), Gaps = 29/462 (6%)

Query: 103 IPIGEESTREENVVKSE-----EGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 157
           IP  + + R  N V +E          +S+ +PPL      K+   S S  T  S A+ +
Sbjct: 260 IPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPP----KRGIPSTSVPTLESAAAIT 315

Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE 217
             T      P   +E  +   G+        ++   P+ +H+  +   +     K     
Sbjct: 316 TKT------PSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVV 369

Query: 218 TRVE---SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 274
             +E   S  L Q +P  E+Q     K ++      P      PPLPL  +   A  +P+
Sbjct: 370 PEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPL 429

Query: 275 VLVSV--GADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVP 332
            +  +  G+    S L  +   ++E+ +   TL     L +  E  K    +EE  +T P
Sbjct: 430 PMTPILEGSHRAHSLLFENSDSFSEDSS---TLGRTRSLPITIEMLKVPDDEEEEEQTCP 486

Query: 333 QLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASK 392
              +   M  +S      +     E + +DSDS+GPI Y D+EDEDE    S +SALA+K
Sbjct: 487 STFSEE-MTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDE----SYQSALANK 541

Query: 393 IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQ 452
           ++R+DTLA+KL +RPS+ EL + N     S+EE  EIR QIG  L+RRLSQRPT EELEQ
Sbjct: 542 VKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ 600

Query: 453 RNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRA 512
           RNIL+ KNE + Q  K E+KRRL+RKLS RPTVAEL AR+ILRFNEYVEVTD+ DYDRRA
Sbjct: 601 RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA 660

Query: 513 DKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 554
           DKPW +LTPADKAAIRKELNEFKS+EMEVHEES+ FTR+HRP
Sbjct: 661 DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 702



 Score =  126 bits (316), Expect = 6e-29
 Identities = 106/340 (31%), Positives = 151/340 (44%), Gaps = 29/340 (8%)

Query: 17  DGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELI 76
           D   AG  TPP KRK K S  GKIFKPWKWRKKK+SDKF+ETS VLERKIS R+ REEL+
Sbjct: 20  DSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELV 79

Query: 77  RRGVLKELPDQDGDVTVNFENS---NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLE 133
           +RGVL E P+Q G+      ++   NGH  PIG  + R  + V+ EE    ++     + 
Sbjct: 80  KRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIG--NARSSSPVQVEEEPVRLASLRKAIP 137

Query: 134 EQAEDKKAGSSHSKKTTGS--------KASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185
           E+   K+ GS+ S+  + +        K    P     SS  +AS+        + GT +
Sbjct: 138 EEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTAR 197

Query: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA-EEQNTGKFKSMV 244
               T      +  ++ T+ + T +L   P+          +T+P A    NT    S+ 
Sbjct: 198 FIISTSITTAPAATTAATSLAKTVNLSVTPSPA-------PRTLPAAPASTNTTATPSLT 250

Query: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304
              P    P P   P       + A  +  +        P   L P + +     T+  T
Sbjct: 251 HMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGI---PSTSVPT 307

Query: 305 LYSGTGL-----SVNRENAKCFTTKEELGKTVPQLLTPGL 339
           L S   +     S  RE + C    E L    P+  +P L
Sbjct: 308 LESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPL 347


>gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
          Length = 580

 Score =  270 bits (689), Expect = 3e-72
 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%)

Query: 351 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 405
           E + ++E   ++SD  D   LYT   ++E+EDED+D S   S+LA K+ R+D+LAIKL N
Sbjct: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430

Query: 406 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 465
           RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ
Sbjct: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490

Query: 466 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 524
           E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK
Sbjct: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550

Query: 525 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 554
           AAIRKELNEFKSTEMEVHE SR  TRFHRP
Sbjct: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580



 Score =  110 bits (276), Expect = 3e-24
 Identities = 51/96 (53%), Positives = 73/96 (76%), Gaps = 1/96 (1%)

Query: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63
           A + +++ +   SD    G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA LE
Sbjct: 83  AAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAALE 141

Query: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSN 99
           RKIS RQSREELI+RGVLKE+ D+DG+++++ E  +
Sbjct: 142 RKISMRQSREELIKRGVLKEIYDKDGELSISNEEDS 177



 Score = 33.1 bits (74), Expect = 0.68
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%)

Query: 334 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 393
           LL P LM  SSE     +D   R  +   S SD P L    E       G+ E       
Sbjct: 41  LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92

Query: 394 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 449
            R D+L       P ++  +  N+ +        +++ E  +     L R++S R + EE
Sbjct: 93  MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152

Query: 450 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 489
           L +R +LK+           NEE+  E    L    S +LSL P ++E++
Sbjct: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198


>gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo
           sapiens]
          Length = 448

 Score =  224 bits (571), Expect = 2e-58
 Identities = 120/208 (57%), Positives = 152/208 (73%), Gaps = 4/208 (1%)

Query: 348 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRP 407
           +A E E ++E    +S+    +L   DE+   D   SG      K   ++ LA+KL NRP
Sbjct: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK---KELLAVKLRNRP 300

Query: 408 SKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEA 467
           SK+ELED+NI  R ++EERQEIRQQI  KL +RLSQRP  EELE+RNILKQ+N++ EQE 
Sbjct: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360

Query: 468 KMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAA 526
           + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV  + DYDRRADKPW RL+ ADKAA
Sbjct: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420

Query: 527 IRKELNEFKSTEMEVHEESRQFTRFHRP 554
           IRKELNE+KS EMEVH  S+  TRFHRP
Sbjct: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 14/172 (8%)

Query: 8   LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 67
           +D+   A  +   +G +TPP +R  KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 1   MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59

Query: 68  TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE------- 120
            RQ REELI++G+L E+ +QD + +       G      E  T +   + SE+       
Sbjct: 60  GRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPL 117

Query: 121 --GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKAS 170
             G   VS    PL   A    AG +   + +  K SA PS     S P  S
Sbjct: 118 ATGTDQVS-LDKPLSSAAHLDDAGQATLFQASSMK-SADPSLRGQLSTPTGS 167


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 42/164 (25%), Positives = 68/164 (41%), Gaps = 10/164 (6%)

Query: 106  GEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSS 165
            G E+  EE   K+ +G      +            A SS S  ++ S +S+S S+SS+SS
Sbjct: 2578 GSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSS 2637

Query: 166  RPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKL 225
               +S  + SS + +  ++     +     +S  ++D  +S +SD +  PA T   S   
Sbjct: 2638 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPS--A 2695

Query: 226  EQTVPGAEEQNTGKF--------KSMVPPPPVAPAPSPLAPPLP 261
            +  +P    +  GK         K    P P AP P P  P  P
Sbjct: 2696 QAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQP 2739



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 52/187 (27%), Positives = 80/187 (42%), Gaps = 11/187 (5%)

Query: 82   KELPDQDG--DVTVNFENSNGHMIPIGEESTREENVVKSEEG--NGSVSEKTPPLEEQAE 137
            K   +QDG  +   +  +S+G        S+        EEG  NG     T      A 
Sbjct: 2546 KAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAA 2605

Query: 138  DKKAGS--SHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPI 195
              +A S  S S  ++ S +S+S S+SS+SS   +S  + SS + +  ++     +     
Sbjct: 2606 SSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2665

Query: 196  TSHLSS--DTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFK-SMVPPPPVAPA 252
            +S  SS  D  +S +SD +  PA T   S   +  +P    +  GK + S   P    PA
Sbjct: 2666 SSSSSSTTDEDSSCSSDDEAAPAPTAGPS--AQAALPTKATKQAGKARPSAHSPGKKTPA 2723

Query: 253  PSPLAPP 259
            P P APP
Sbjct: 2724 PQPQAPP 2730



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 11/188 (5%)

Query: 78   RGVLKELPDQDGDVTVNFENSNGHMIPIGE-ESTREENVVKSEEGNGSVSEKTPPLEEQA 136
            RG+L +L D    +TV F++ +   IP+        +  ++  E + ++   +     + 
Sbjct: 2248 RGLL-DLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRK 2306

Query: 137  EDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPIT 196
              K  G      T GS+   +       +R +  K +  +K     T +    TD+ P T
Sbjct: 2307 TSKDTGEGKDGGTAGSEEPGA------KARGRGRKPSAKAKGDRAATLEEGNPTDEVPST 2360

Query: 197  SHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVA--PAPS 254
                  ++T G+     EP + R ++ K  +  P         F S   P P A  PAP+
Sbjct: 2361 PLALEPSSTPGSKKSPPEPVDKRAKAPK-ARPAPPQPSPAPPAFTSCPAPEPFAELPAPA 2419

Query: 255  PLAPPLPL 262
                P PL
Sbjct: 2420 TSLAPAPL 2427


>gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo
           sapiens]
          Length = 373

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 41/208 (19%), Positives = 91/208 (43%), Gaps = 23/208 (11%)

Query: 354 GHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELE 413
           GH+ +Q ++ D DG      D++ED DED     A  + +R  +          S+   E
Sbjct: 71  GHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQE 130

Query: 414 DKNILQ--------------RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNIL--- 456
           ++  ++                 +EER  ++ +   +L ++L +R   EE E+R I+   
Sbjct: 131 EQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE 190

Query: 457 ------KQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDR 510
                 ++KNE++ +E + ++ + +  K +       LQ +   ++ E+++  ++ + +R
Sbjct: 191 KHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECER 250

Query: 511 RADKPWARLTPADKAAIRKELNEFKSTE 538
           +  +         +   +KE+ E K  E
Sbjct: 251 KKKEKEKEKQQQAEIQEKKEIAEKKFQE 278


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 27/212 (12%)

Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410
           +DE   EY  ++ + +       +  E E E  S  +       RRD L ++  N+   +
Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 465
            L  + +LQ     E++E ++Q+  +  +R+ Q     R   E+  +    +++ E E++
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 466 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 520
             + E KRRL      RK       AE + RR+ R  EY+         R+ ++    L 
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR--------RQLEEEQRHLE 480

Query: 521 PADKAAIRKE--LNEFKSTEMEVHEESRQFTR 550
              +  ++++  L E +  EME H ++ +  R
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 108/500 (21%), Positives = 179/500 (35%), Gaps = 105/500 (21%)

Query: 10  KASIANSDGPTAGSQTPPFKRKGKLSTIGKIF------KPWKWRKKKTSDKFRETSAVLE 63
           KA  ++SD  ++    PP  +K K++ +          KP +   K  + K   +S+   
Sbjct: 163 KAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSS 222

Query: 64  RKISTRQSREELIRRGVLKELPDQD-------GDVTVNFENSNGHMIPIGEESTREENVV 116
              S+  S EE       K +P +           T     S+       +E   ++  +
Sbjct: 223 SSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPM 282

Query: 117 KSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTT-------GSKASASPSTSSTSSRPKA 169
           K++ G  S     PP       K  G+   KK          S+ S+  S SS+    K 
Sbjct: 283 KNKPGPYS---SVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339

Query: 170 SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 229
             + V SKA    TTK      K   +S  SSD+ +S   +   +PA             
Sbjct: 340 PTKAVVSKA----TTK-PPPAKKAAESSSDSSDSDSSEDDEAPSKPA------------- 381

Query: 230 PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 289
            G  + ++ K       P V PA +P  P                  V  G  L     D
Sbjct: 382 -GTTKNSSNKPAVTTKSPAVKPAAAPKQP------------------VGGGQKLLTRKAD 422

Query: 290 PSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSA 349
            S    +EE ++                    +++EE  K +     P    +++ S  A
Sbjct: 423 SSS---SEEESS--------------------SSEEEKTKKMVATTKPKATAKAALSLPA 459

Query: 350 SE-DEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPS 408
            +  +G R     DS SD     +D    +E+E+ + +SA+  K ++     +  G  PS
Sbjct: 460 KQAPQGSR-----DSSSD-----SDSSSSEEEEEKTSKSAVKKKPQK-----VAGGAAPS 504

Query: 409 KKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPT------TEELEQRNILKQKNEE 462
           K     K   + ++     +  ++   KL  + S RP       T  L  +N    KN E
Sbjct: 505 KPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSE 564

Query: 463 EEQEAKMELKRRLSRKLSLR 482
           EE+E K +    +S+  SL+
Sbjct: 565 EEEEEKKKAAVVVSKSGSLK 584


>gi|238624188 diffuse panbronchiolitis critical region 1 protein
           [Homo sapiens]
          Length = 1393

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 79/368 (21%), Positives = 131/368 (35%), Gaps = 38/368 (10%)

Query: 47  RKKKTSDKFRETSAVLERKIST--------------RQSREELIRRGVLKELPDQDGDVT 92
           R  K +DK    S  ++ K ST               Q ++ +IR    + +   D   T
Sbjct: 91  RHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQ--RSVDPADSTTT 148

Query: 93  VNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP----PLEEQAEDKKAGSSHSKK 148
                   H+ P  +      N  KS  G  +V+ K+     PLE+        S+ S K
Sbjct: 149 HKESAGKKHITPAPKSKI---NCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHK 205

Query: 149 TTGSKASASPSTSSTSSRPKASKETVSSKAG--TVGTTKGKRKTDKQPITSHLSSDTTTS 206
           TT S  ++  S +   S     K T +SK    T GT +   KT+    T+  S    T 
Sbjct: 206 TTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSR-TTVASDKLLTK 264

Query: 207 GTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPP----VAPAPSPLAPPLPL 262
            T +++   +   +     E T  G    N     S   P       A   + L+P  P+
Sbjct: 265 TTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPI 324

Query: 263 EDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT--------NRTTLYSGTGLSVN 314
           E++  TA++      +   +      + +  L+  EPT          TT          
Sbjct: 325 ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG 384

Query: 315 RENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374
              A   TT      T     TP    +++ S + S + G R   AN++ +  P   T++
Sbjct: 385 ERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTEN 444

Query: 375 EDEDEDED 382
            +   +E+
Sbjct: 445 RERTANEN 452



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 71/320 (22%), Positives = 116/320 (36%), Gaps = 50/320 (15%)

Query: 99  NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASP 158
           +G   P+  E+T       +E    + +EKT P   +  + +  +++   T     S + 
Sbjct: 703 HGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANENTT----PSPAQ 758

Query: 159 STSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTT---------TSGTS 209
            T +    P A+++T  S A    T  GKR       T+  S++ T            T+
Sbjct: 759 PTENGDRTPLANEKTTPSLAEP--TENGKRTPFANEKTTSSSAEPTEHAERTPLANENTT 816

Query: 210 DLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITA 269
               EP E R  +   + T   AE     +  +     P         P  P E++  TA
Sbjct: 817 SSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPF--------PAEPTENREWTA 868

Query: 270 SDTPVVLVSVGADLPVSALDPSQLLWAEEPT---NRTTLYSGTGLSVNRENAKCFTTKEE 326
           ++              + L P++    EE T   N  T  S    + N E    FT +  
Sbjct: 869 NEN-------------TTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTP-FTNE-- 912

Query: 327 LGKTVPQLLTPGLMGESS------ESFSASEDEGHREYQANDSDSDGPILYTDDEDEDED 380
             KT P    P   GE +       + S +E   H E  AN+  +  P   T+  +   +
Sbjct: 913 --KTTPSSAEPTEHGERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVN 970

Query: 381 EDGSGESALASKIRRRDTLA 400
           ED +  SA  ++   R  LA
Sbjct: 971 EDTTPSSAEPTENGERTPLA 990



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 65/287 (22%), Positives = 108/287 (37%), Gaps = 38/287 (13%)

Query: 99  NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS-KASAS 157
           +G   P+  E+T       +E    + +E T P         AG + +++TT + K + S
Sbjct: 423 HGERTPLANENTTPSPAEPTENRERTANENTTP-------SPAGPTENRETTANEKTTLS 475

Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG---------T 208
           P   + +    A+++T  S A    T  G+R       T+  S++ T  G         T
Sbjct: 476 PVEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTPLANENT 533

Query: 209 SDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCIT 268
           +    EP E R E    E+T P   E      ++ +      P+   LA P     +   
Sbjct: 534 TPSPAEPTENR-ERTANEKTTPSPAEPTENGDRTPLANEKTTPS---LAEPTENGQRTPF 589

Query: 269 ASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRE-NAKCFTTKEEL 327
           A++              S+ +P++        N  T  S    + NRE  A   TT    
Sbjct: 590 ANEKTT----------SSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 639

Query: 328 GKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374
           G T  + +T     E +  F A   E +RE  AN+  +  P   T++
Sbjct: 640 GPTENREMT---ANEKTTLFPAEPTE-NRERTANEKTTSSPAEPTEN 682



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 56/300 (18%), Positives = 112/300 (37%), Gaps = 34/300 (11%)

Query: 108 ESTREENVVKSEEGNGSVSEKTPPLE-EQAEDKKAGSSHSKKTTGSKAS----------A 156
           E T    V  +E    + +EKT P   E  E+ +     ++KTT S A           A
Sbjct: 470 EKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 529

Query: 157 SPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPA 216
           + +T+ + + P  ++E  +++  T    +     D+ P+ +  ++ +    T + +  P 
Sbjct: 530 NENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP- 588

Query: 217 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVL 276
                 F  E+T   + E    + ++ +      P+P   A P    ++    + TP   
Sbjct: 589 ------FANEKTTSSSAEPTEHEERTPLANENTTPSP---AEPTENRERTANENTTPS-- 637

Query: 277 VSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT 336
                  P    +  ++   E    +TTL+           A   TT      T     T
Sbjct: 638 -------PAGPTENREMTANE----KTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 686

Query: 337 PGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR 396
           P    +++ S +   + G R   AN++ +  P   T++ +   +E  +   A  ++ R R
Sbjct: 687 PFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRER 746



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 47/198 (23%), Positives = 79/198 (39%), Gaps = 44/198 (22%)

Query: 85   PDQDGDVTVNFENS--------NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPL-EEQ 135
            P + G+ TVN + +        NG   P+  E+T       +E G  + +EKT P   E 
Sbjct: 961  PTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTEHGERTANEKTTPSPAEP 1020

Query: 136  AEDKKAGSSHSKKTTGSKA----------SASPSTSSTSSRP--KASKETVSSKAGTV-- 181
             E  +   S ++KT  S A          SA+ +T+ +  +P     K T++++  T+  
Sbjct: 1021 TEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSP 1080

Query: 182  -GTTKGKRKTD--KQPITSHLSSDT-----TTSGTSDLKGEPAETRVESFKLEQTVPGAE 233
             G T+   KT    + IT  L+  T     TTS    +    AE+              E
Sbjct: 1081 EGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAES-------------TE 1127

Query: 234  EQNTGKFKSMVPPPPVAP 251
             ++     +++ P P  P
Sbjct: 1128 HRDRATSANVITPAPAEP 1145



 Score = 29.3 bits (64), Expect = 9.9
 Identities = 33/165 (20%), Positives = 53/165 (32%), Gaps = 27/165 (16%)

Query: 105  IGEESTREENVVKSEEGNGSVSEKTPPL---------------EEQAEDKKAGSSHSKKT 149
            I  E         +E G  +V+E T P                E         + H ++T
Sbjct: 949  IANEKATPSPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTEHGERT 1008

Query: 150  TGSKASASPS--TSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG 207
               K + SP+  T      P A+++T+ S A         + T+ + +T   + +TT S 
Sbjct: 1009 ANEKTTPSPAEPTEHGERTPSANEKTIPSPA---------KPTEHEEMTPSANENTTPSP 1059

Query: 208  TSDLK-GEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAP 251
                + GE      E   L    P      T      + P    P
Sbjct: 1060 VKPTEHGEKTTLANEKITLSPEGPTEHGAKTTSANEKITPSLAKP 1104


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 104/553 (18%), Positives = 202/553 (36%), Gaps = 94/553 (16%)

Query: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENS----NGHMIPIG------------E 107
           +K + R   + L + G+ + +P      ++  EN     N +++P              E
Sbjct: 34  QKTTARHGLQSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEE 93

Query: 108 ESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRP 167
           E T E    + + G  +  E  P  +  A +K+ G     +         PS  +   + 
Sbjct: 94  EKTPEVPPAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQE 153

Query: 168 KASKETVSSKAG------------------TVGTTKGKRKTDKQPITSHLSSDTTTSGTS 209
           K  KET     G                    G+     + +K P       D +T+GTS
Sbjct: 154 KKEKETNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLP-----GQDESTAGTS 208

Query: 210 DLKG--EPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPL--PLEDQ 265
           +     +  E R+     +  + G +     ++++M+PP      P    PPL  P+   
Sbjct: 209 EQNDILKVVEKRIACGPPQAKLNGQQAALASQYRAMMPPYMFQQYPRMTYPPLHGPMR-- 266

Query: 266 CITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNR-ENAKCFTTK 324
                  P  L      L      PS   WA EP   + L +     +++ +N      +
Sbjct: 267 ------FPPSLSETNKGLRGRGPPPS---WASEPERPSILSASELKELDKFDNLDAEADE 317

Query: 325 EELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGS 384
              G  +    T  L      +FS  +++G    + N+S+  G     ++E++ E ++ S
Sbjct: 318 GWAGAQMEVDYTEQL------NFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVS 371

Query: 385 GESALASKIRRRDTLAIKLGNRPSKKELE---------DKNILQRTSEEERQEI------ 429
              + +    +     +  G  PS  +            K + Q+    +RQ +      
Sbjct: 372 NTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGP 431

Query: 430 ---RQQIGTK----LVRRLSQRPTTEELE----QRNILKQKNEEEEQEAKMELKRRLSRK 478
              +QQ+  +      RR  Q   +  +E    +R   +++ EE+ + A  E  +RL  K
Sbjct: 432 FPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEK 491

Query: 479 LSL---RPTVAELQARRILRFNE-YVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEF 534
           L +   +P+  E++ R   +  E   E+    + +R  ++   R    +K    KEL + 
Sbjct: 492 LGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEK---EKELEKE 548

Query: 535 KSTEMEVHEESRQ 547
           +  + E+ +E +Q
Sbjct: 549 QEKQREMEKERKQ 561



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/154 (25%), Positives = 72/154 (46%), Gaps = 21/154 (13%)

Query: 337 PGLMGE-SSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDE--DGSGESALASKI 393
           PG  G   S+   A EDE  ++ +   S+    +       E+E+   +   ++A A K+
Sbjct: 426 PGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKL 485

Query: 394 RRRDTLAIKLGNRPS---------KKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQR 444
           +R D     L  +PS         +KE E +  L++  E+ER++ R++       R  Q+
Sbjct: 486 KRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREK------DRERQQ 539

Query: 445 PTTEELEQRNILKQKNEEEEQEAKMELKRRLSRK 478
              +ELE+    ++K  E E+E K E ++ L R+
Sbjct: 540 EKEKELEKE---QEKQREMEKERKQEKEKELERQ 570



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 34/162 (20%), Positives = 63/162 (38%), Gaps = 19/162 (11%)

Query: 107 EESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSR 166
           +E  +E   +K +E    + ++   LEE+ E ++       +   S+ S +       +R
Sbjct: 571 KEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTR 630

Query: 167 PKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTS----------DLKGEPA 216
             +++   S K  T    + + ++  QP  + LS        S           +K +  
Sbjct: 631 QDSNR---SEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQW 687

Query: 217 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAP 258
           + + +   L QTVP     +T      VPPPP  P   P+ P
Sbjct: 688 QQQQQQGVLPQTVPSQPSSST------VPPPPHRPLYQPMQP 723



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 47/241 (19%), Positives = 90/241 (37%), Gaps = 40/241 (16%)

Query: 85   PDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG-------SVSEKTPPLEEQAE 137
            P ++    V  + S    +  G   T++ +  +SE   G        +  K P    + +
Sbjct: 907  PQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEK 966

Query: 138  DKKAGSSHS------KKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTD 191
             KK G   S      +K   SK+        +S+R +   +    ++G +          
Sbjct: 967  PKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPI---------- 1016

Query: 192  KQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAP 251
            K+P+   +  +       + +GE AE   E   ++        + T K K + PPPP   
Sbjct: 1017 KKPVLRDMKEEREQR--KEKEGEKAEKVTEKVVVKP-------EKTEK-KDLPPPPPPPQ 1066

Query: 252  APSPLAP---PLPLEDQC----ITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304
             P+P+ P   P P++ +      T + T     S   + P+  +   Q+  A +  N+ T
Sbjct: 1067 PPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQT 1126

Query: 305  L 305
            +
Sbjct: 1127 M 1127



 Score = 30.0 bits (66), Expect = 5.8
 Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 7/126 (5%)

Query: 172  ETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE------TRVESFKL 225
            E VS K       + +RK ++Q I      +    G S     P        T ++  + 
Sbjct: 1683 EVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGIQQAQS 1742

Query: 226  EQTVPG-AEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLP 284
              +VP  A         + VP    AP P+ L P        + AS    VL S  A +P
Sbjct: 1743 SASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVP 1802

Query: 285  VSALDP 290
             S L P
Sbjct: 1803 ASPLAP 1808



 Score = 29.3 bits (64), Expect = 9.9
 Identities = 31/111 (27%), Positives = 55/111 (49%), Gaps = 18/111 (16%)

Query: 373 DDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQ 432
           + E E E E    +     K R +D    +   +  +KELE +   QR  E+ER++ +++
Sbjct: 510 EKEREREKELEKEQEQEREKEREKD----RERQQEKEKELEKEQEKQREMEKERKQEKEK 565

Query: 433 IGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKR-RLSRKLSLR 482
              +L R   Q+   +EL       QK +E+E+E ++E +R +L  K+  R
Sbjct: 566 ---ELER---QKEKEKEL-------QKMKEQEKECELEKEREKLEEKIEPR 603


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis
           critical region 1 [Homo sapiens]
          Length = 1400

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 79/368 (21%), Positives = 130/368 (35%), Gaps = 38/368 (10%)

Query: 47  RKKKTSDKFRETSAVLERKIST--------------RQSREELIRRGVLKELPDQDGDVT 92
           R  K +DK    S  ++ K ST               Q ++ +IR    + +   D   T
Sbjct: 153 RHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQ--RSVDPADSTTT 210

Query: 93  VNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP----PLEEQAEDKKAGSSHSKK 148
                   H+ P  +      N  KS  G  +V+ K+     PLE+        S+ S K
Sbjct: 211 HKESAGKKHITPAPKSKI---NCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHK 267

Query: 149 TTGSKASASPSTSSTSSRPKASKETVSSKAG--TVGTTKGKRKTDKQPITSHLSSDTTTS 206
           TT S  ++  S +   S     K T +SK    T GT +   KT+    T+  S    T 
Sbjct: 268 TTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSR-TTVASDKLLTK 326

Query: 207 GTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPP----VAPAPSPLAPPLPL 262
            T +++   +   +     E T  G    N     S   P       A   + L+P  P 
Sbjct: 327 TTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPT 386

Query: 263 EDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT--------NRTTLYSGTGLSVN 314
           E++  TA++      +   +      + +  L+  EPT          TT          
Sbjct: 387 ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG 446

Query: 315 RENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374
              A   TT      T     TP    +++ S + S + G R   AN++ +  P   T++
Sbjct: 447 ERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTEN 506

Query: 375 EDEDEDED 382
            +   +E+
Sbjct: 507 RERTANEN 514



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 65/287 (22%), Positives = 108/287 (37%), Gaps = 38/287 (13%)

Query: 99  NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS-KASAS 157
           +G   P+  E+T       +E    + +E T P         AG + +++TT + K + S
Sbjct: 485 HGERTPLANENTTPSPAEPTENRERTANENTTP-------SPAGPTENRETTANEKTTLS 537

Query: 158 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG---------T 208
           P   + +    A+++T  S A    T  G+R       T+  S++ T  G         T
Sbjct: 538 PVEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTPLANENT 595

Query: 209 SDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCIT 268
           +    EP E R E    E+T P   E      ++ +      P+   LA P     +   
Sbjct: 596 TPSPAEPTENR-ERTANEKTTPSPAEPTENGDRTPLANEKTTPS---LAEPTENGQRTPF 651

Query: 269 ASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRE-NAKCFTTKEEL 327
           A++              S+ +P++        N  T  S    + NRE  A   TT    
Sbjct: 652 ANEKTT----------SSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 701

Query: 328 GKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 374
           G T  + +T     E +  F A   E +RE  AN+  +  P   T++
Sbjct: 702 GPTENREMT---ANEKTTLFPAEPTE-NRERTANEKTTSSPAEPTEN 744



 Score = 37.0 bits (84), Expect = 0.047
 Identities = 56/300 (18%), Positives = 112/300 (37%), Gaps = 34/300 (11%)

Query: 108 ESTREENVVKSEEGNGSVSEKTPPLE-EQAEDKKAGSSHSKKTTGSKAS----------A 156
           E T    V  +E    + +EKT P   E  E+ +     ++KTT S A           A
Sbjct: 532 EKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 591

Query: 157 SPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPA 216
           + +T+ + + P  ++E  +++  T    +     D+ P+ +  ++ +    T + +  P 
Sbjct: 592 NENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP- 650

Query: 217 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVL 276
                 F  E+T   + E    + ++ +      P+P   A P    ++    + TP   
Sbjct: 651 ------FANEKTTSSSAEPTEHEERTPLANENTTPSP---AEPTENRERTANENTTPS-- 699

Query: 277 VSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT 336
                  P    +  ++   E    +TTL+           A   TT      T     T
Sbjct: 700 -------PAGPTENREMTANE----KTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 748

Query: 337 PGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR 396
           P    +++ S +   + G R   AN++ +  P   T++ +   +E  +   A  ++ R R
Sbjct: 749 PFANEKTTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRER 808



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 26/190 (13%)

Query: 99  NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASP 158
           +G   P+  E+T       +E    + +EKT P   +  + +  +++   T     S + 
Sbjct: 765 HGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRERTANENTT----PSPAQ 820

Query: 159 STSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTT---------TSGTS 209
            T +    P A+++T  S A    T  GKR       T+  S++ T            T+
Sbjct: 821 PTENGDRTPLANEKTTPSLAEP--TENGKRTPFANEKTTSSSAEPTEHAERTPLANENTT 878

Query: 210 DLKGEPAETRVESFKLEQTVPGAE--EQNTGKFKSMVPPPPVAPAP---------SPLAP 258
               EP E R  +   + T   AE  E           P P  P           + L+P
Sbjct: 879 SSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSP 938

Query: 259 PLPLEDQCIT 268
             P E + +T
Sbjct: 939 AEPTEHEEMT 948



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 4/111 (3%)

Query: 118  SEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSK 177
            ++    ++S K      ++    A  + ++ TT S     P+T+ST+        TVSS 
Sbjct: 1197 TDSATTAISTKASGTTVESAPSTAPPTPAETTTASV----PTTTSTTGSENTGHHTVSSV 1252

Query: 178  AGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQT 228
              TV  T  +  T  +   +  S+   T+  +      +ET V S K   T
Sbjct: 1253 PTTVFATASESSTGSETTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVT 1303



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 8/131 (6%)

Query: 141  AGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLS 200
            A ++ S K +G+   ++PST+     P    ET ++   T  +T G   T    ++S  +
Sbjct: 1200 ATTAISTKASGTTVESAPSTA-----PPTPAETTTASVPTTTSTTGSENTGHHTVSSVPT 1254

Query: 201  SDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMV-PPPPVAPAPSPLAPP 259
            +   T+  S    E   TR  +   E T        TG   ++V    PV    S  +  
Sbjct: 1255 TVFATASESSTGSE--TTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVTTTQSGFSTA 1312

Query: 260  LPLEDQCITAS 270
              +  +  TAS
Sbjct: 1313 TVMPAKTTTAS 1323



 Score = 30.4 bits (67), Expect = 4.4
 Identities = 57/238 (23%), Positives = 89/238 (37%), Gaps = 32/238 (13%)

Query: 124  SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 183
            +VSE         E   A ++ S  TT S  ++ P+T+STS     +    +    T+  
Sbjct: 1035 AVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKNTTACEATMSETTIAA 1094

Query: 184  TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 243
                  T     TS +++++     +     P +T   S  +  TVP   + NT    + 
Sbjct: 1095 ITASEDTTVSTQTSVIAAESVPHTATK---TPTDTTTAS--VSATVP---KNNTLSVITS 1146

Query: 244  VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWA--EEPTN 301
             P    + AP+  +  +       TAS T     S    LP +    +  + A  E PT 
Sbjct: 1147 TP----STAPNTASKTM------TTASKT--TTTSTITSLPTTVFTTTSKITAGSEIPTA 1194

Query: 302  RTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESS----ESFSASEDEGH 355
             TT  + T +S         TT E    T P   TP     +S     S + SE+ GH
Sbjct: 1195 STTDSATTAISTKASG----TTVESAPSTAPP--TPAETTTASVPTTTSTTGSENTGH 1246


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 17/160 (10%)

Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410
           +DE   EY  ++ + +       +  E E E  S  +       RRD L ++  N+   +
Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 465
            L  + +LQ     E++E ++Q+  +  +R+ Q     R   E+  +    +++ E E++
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 466 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYV 500
             + E KRRL      RK       AE + RR+ R  EY+
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 17/160 (10%)

Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410
           +DE   EY  ++ + +       +  E E E  S  +       RRD L ++  N+   +
Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 465
            L  + +LQ     E++E ++Q+  +  +R+ Q     R   E+  +    +++ E E++
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 466 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYV 500
             + E KRRL      RK       AE + RR+ R  EY+
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468


>gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]
          Length = 1426

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/259 (22%), Positives = 105/259 (40%), Gaps = 32/259 (12%)

Query: 139 KKAGSSHSKKT-TGSKASASPSTSSTSSRPKASKETVSSKA---------------GTVG 182
           K   S H+  + T S A+A  S++ +  +  A++ T + K                    
Sbjct: 132 KSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEA 191

Query: 183 TTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQT--VPGAEEQNTGKF 240
             KG+ +T       ++S++ T   T+ L  + +  R +   L Q    P  ++QN+ + 
Sbjct: 192 VLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQN 251

Query: 241 KSMVPPPPV-APAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEP 299
             + P PP+ APAP P APP PL+ +     +   ++ SVG+    + L P        P
Sbjct: 252 TRLQPTPPIPAPAPKPAAPPRPLDRESPGVENK--LIPSVGSPASSTPLPPDGTGPNSTP 309

Query: 300 TNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT--PGLMGESSESFSASEDEGHRE 357
            NR       G + +  + K            P + +  P  +GE+ +  S  + E HRE
Sbjct: 310 NNRAVTPVSQGSNSSSADPK--------APPPPPVSSGEPPTLGENPDGLSQEQLE-HRE 360

Query: 358 YQANDSDSDGPILYTDDED 376
                      +L+ D+++
Sbjct: 361 RSLQTLRDIQRMLFPDEKE 379


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 107/496 (21%), Positives = 176/496 (35%), Gaps = 70/496 (14%)

Query: 48   KKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGE 107
            K  + DK RE + +LE   S+R   +++I      +  D++     + EN     I    
Sbjct: 913  KVSSVDKQREQTEILE---SSRMRAQDIIGH---HQSEDRETSDRAHDENKKKAKIQKKP 966

Query: 108  ESTREENVVKSEEGN-GSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSR 166
               ++E+ V  E GN  + SE       +   KK      +K +   +  S   ++  S+
Sbjct: 967  IKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSK 1026

Query: 167  PKASKET--VSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFK 224
             K    T  +++K   V    GK    +    S    DT  S  SD   E    R E  +
Sbjct: 1027 KKRGPRTPPITTKEELVEMCNGKNGILED---SQKKEDTAFSDWSD---EDVPDRTEVTE 1080

Query: 225  LEQTVPGAEEQNTGKFKSMV--PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGAD 282
             E T       +T    S +  PPPPVA A               TA+  P  L +  A 
Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATA---------------TATTVPATLAATTAA 1125

Query: 283  LPVS-ALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMG 341
               S +     +  +  PTN T        +    + KC  T+ E  +T P +       
Sbjct: 1126 AATSFSTSAITISTSATPTNTTN----NTFANEDSHRKCHRTRVEKVET-PHVTIEDAQH 1180

Query: 342  ESSESFSASEDEGHREYQANDSDSDGPILY--TDDEDEDEDEDGSGESALASKIRRRD-T 398
                    S   G    ++N S + G +     D      D+    +  L S  R R+ T
Sbjct: 1181 RKPMDQKRSSSLGSN--RSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKT 1238

Query: 399  LAIKL-GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILK 457
             ++++ G R S+ +   +    R++  +RQ+ R         R S   +  ++  R+   
Sbjct: 1239 KSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS-----RRSSPESDRQVHSRSGSF 1293

Query: 458  QKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWA 517
               +  ++  + E  R   R+            RR  R  E+         DR ADK W 
Sbjct: 1294 DSRDRLQERDRYEHDRERERE------------RRDTRQREW---------DRDADKDWP 1332

Query: 518  RLTPADKAAIRKELNE 533
            R    D+   R+   E
Sbjct: 1333 RNRDRDRLRERERERE 1348



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 35/173 (20%), Positives = 74/173 (42%), Gaps = 13/173 (7%)

Query: 38   GKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFEN 97
            G++F P K +KKK+ +K R+ S   +  IS  ++ ++  ++   +  P    +  V   N
Sbjct: 989  GQVFSPKKGQKKKSIEKKRKKSKG-DSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCN 1047

Query: 98   SNGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 157
                ++   E+S ++E+   S+  +  V ++T   E         + H+   T   ++ S
Sbjct: 1048 GKNGIL---EDSQKKEDTAFSDWSDEDVPDRTEVTE---------AEHTATATTPGSTPS 1095

Query: 158  PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSD 210
            P +S     P  +  T ++   T+  T     T        +S+  T + T++
Sbjct: 1096 PLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTN 1148



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 17/149 (11%)

Query: 47  RKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNF----------E 96
           RK+ +  + RE   +   K  T +S EE +     ++  D +GD+  ++          +
Sbjct: 113 RKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSD-NGDINYDYVHELSLEMKRQ 171

Query: 97  NSNGHMIPIGEEST--REENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKA 154
                ++ + +E+   REE ++K E     V  K  P     +  K+    S   + S +
Sbjct: 172 KIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSAS 231

Query: 155 SASPSTSSTSS----RPKASKETVSSKAG 179
                TS+ SS    + + SK   S K G
Sbjct: 232 KKDRKTSAVSSPLLDQQRNSKTNQSKKKG 260



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 42/201 (20%), Positives = 78/201 (38%), Gaps = 29/201 (14%)

Query: 351 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 410
           E +  RE +  D   D       + D + + D   E     + R RD        R  ++
Sbjct: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERER---ERERERDR------EREKER 705

Query: 411 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKME 470
           ELE +   +R  E E++  R++   +   R  +R    + E+    +++  E E+E + E
Sbjct: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERE 765

Query: 471 LKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKE 530
            +R   R+          + R   R  E     D  D D+  D         D+   R+E
Sbjct: 766 RERERERE----------RERARERDKERERQRDWEDKDKGRD---------DRREKREE 806

Query: 531 LNEFKSTEMEVHEESRQFTRF 551
           + E ++   + H+E +   R+
Sbjct: 807 IREDRNPR-DGHDERKSKKRY 826


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 42/191 (21%), Positives = 85/191 (44%), Gaps = 31/191 (16%)

Query: 371 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 424
           Y+  E+E+E+ D    S++ +       RRD L ++L N+   + L  + +   QR +EE
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382

Query: 425 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 471
            ++++  +   ++  +  QR   EE              EQR   +++   EE+  + E 
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442

Query: 472 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 522
           ++   RK       AE   R++ +  +Y+    S  + R+  +P  +         ++P+
Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499

Query: 523 DKAAIRKELNE 533
           +K A  KE+ E
Sbjct: 500 EKPAWAKEVEE 510


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 42/191 (21%), Positives = 85/191 (44%), Gaps = 31/191 (16%)

Query: 371 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 424
           Y+  E+E+E+ D    S++ +       RRD L ++L N+   + L  + +   QR +EE
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382

Query: 425 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 471
            ++++  +   ++  +  QR   EE              EQR   +++   EE+  + E 
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442

Query: 472 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 522
           ++   RK       AE   R++ +  +Y+    S  + R+  +P  +         ++P+
Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499

Query: 523 DKAAIRKELNE 533
           +K A  KE+ E
Sbjct: 500 EKPAWAKEVEE 510


>gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens]
          Length = 490

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 15/194 (7%)

Query: 13  IANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSR 72
           ++N D  T  S     K++ +     + F+  K RKKK     R+T++VL +     +S 
Sbjct: 268 VSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQA-RKTASVLSKDDVAPESG 326

Query: 73  EELIRRGVLK--ELPDQD------GDVTVNFENSNG----HMIPIGEESTREENVVKSEE 120
           +  +++   K  + P+        G   V   N +      ++PIG+++   E V   + 
Sbjct: 327 DTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKH 386

Query: 121 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 180
             G  S    P       KK  +  + +T  +  S +P   S   +PK  +E V  K+ +
Sbjct: 387 ATGKKSPAKSPNPSTPRGKKRKALPASETPKAAESETPG-KSPEKKPKIKEEAVKEKSPS 445

Query: 181 VGTTKGKRKTDKQP 194
           +G  K  R+T K+P
Sbjct: 446 LG-KKDARQTPKKP 458


>gi|92859701 myosin VI [Homo sapiens]
          Length = 1285

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 52/224 (23%), Positives = 103/224 (45%), Gaps = 40/224 (17%)

Query: 324  KEELGKTVPQL-LTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDED 382
            K E+ K +  L ++   +    +S   ++++  +EY A    S+  +     + + E+E 
Sbjct: 864  KPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEE- 922

Query: 383  GSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLS 442
                   A ++RR   +  ++     ++E ++K   +R  EEE + ++ ++  K  +   
Sbjct: 923  -------AERLRR---IQEEMEKERKRREEDEK---RRRKEEEERRMKLEMEAKRKQEEE 969

Query: 443  QRPTTEELEQR-------NILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILR 495
            +R   E+ E+R        + +QK EE +Q+A +E +RR  R+L+LR   +E +      
Sbjct: 970  ERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERR-DRELALRIAQSEAEL----- 1023

Query: 496  FNEYVEVTDSPDYD---RRADKPWARLTPADKAAIRKELNEFKS 536
                  ++D    D   RR D    ++TP   A   KE++EF S
Sbjct: 1024 ------ISDEAQADLALRRNDGTRPKMTPEQMA---KEMSEFLS 1058


>gi|195976782 Paf1/RNA polymerase II complex component [Homo
           sapiens]
          Length = 710

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 47/196 (23%), Positives = 84/196 (42%), Gaps = 12/196 (6%)

Query: 314 NRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTD 373
           N+   K    K E   T+ +         SS+  S++E     E + +DSDS+     +D
Sbjct: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSD 168

Query: 374 DEDEDEDE---DGSGESALASK--IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQE 428
            +   EDE   DG GE  +  +    R + +  K   +     +E + +L+R     R E
Sbjct: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKR-----RFE 223

Query: 429 IRQQIGT-KLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLR-PTVA 486
           I++++ T K   +  ++   EE +++  L Q  E +      E + +   KL  +   + 
Sbjct: 224 IKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283

Query: 487 ELQARRILRFNEYVEV 502
           EL+A R  R N   E+
Sbjct: 284 ELKAEREKRKNRTAEL 299


>gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo
           sapiens]
          Length = 229

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/135 (23%), Positives = 60/135 (44%), Gaps = 14/135 (10%)

Query: 354 GHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELE 413
           GH+ +Q ++ D DG      D++ED DED     A  + +R  +          S+   E
Sbjct: 71  GHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQE 130

Query: 414 DKNILQ--------------RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQK 459
           ++  ++                 +EER  ++ +   +L ++L +R   EE E+R I+ ++
Sbjct: 131 EQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE 190

Query: 460 NEEEEQEAKMELKRR 474
             +E  + K E  RR
Sbjct: 191 KHKEWVQKKNEQVRR 205


>gi|118498337 HECT domain containing 1 [Homo sapiens]
          Length = 2610

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 71/314 (22%), Positives = 122/314 (38%), Gaps = 47/314 (14%)

Query: 113  ENVVKSEEGNGS---VSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKA 169
            ENV ++E G+ S    S  T     +  ++K G   S +T G  ++ S    S SS   +
Sbjct: 1433 ENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVS 1492

Query: 170  SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 229
            S          V     K    ++P++S  S+  + S      G P  +         +V
Sbjct: 1493 S----------VSELTNKEAASQRPLSSSASNRLSVSSLL-AAGAPMSSSA-------SV 1534

Query: 230  PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 289
            P    + T   +S V         + +A      +  ++ S +     ++G ++  +A  
Sbjct: 1535 PNLSSRETSSLESFVR------RVANIARTNATNNMNLSRSSSDNNTNTLGRNVMSTATS 1588

Query: 290  PSQLLWAEE------PTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 343
            P  L+ A+       P   +T+   T    +  N    TT   +G+++   LT  L   S
Sbjct: 1589 P--LMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTS 1646

Query: 344  SESFSASEDEGHREYQANDS----------DSDGPILYTDDED-EDEDEDGSGESALASK 392
            SES +  E E +  Y   DS          D D  +   D+ED E+ED++   +      
Sbjct: 1647 SESDTGQEAE-YSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVM 1705

Query: 393  IRRRDTLAIKLGNR 406
            I RR +L  + G+R
Sbjct: 1706 ILRRPSLQRRAGSR 1719


>gi|145580582 uromodulin-like 1 isoform 2 precursor [Homo sapiens]
          Length = 1446

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 44/171 (25%), Positives = 66/171 (38%), Gaps = 22/171 (12%)

Query: 78  RGVLKELP--------DQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKT 129
           +GV +E+P        DQ     VN    +     + +EST + +  +     GS S+  
Sbjct: 628 KGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVN 687

Query: 130 PPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRK 189
           P    Q     A SS    + GS +  SPS  STS    + + T+    G +GTT   + 
Sbjct: 688 P---SQRSTSHANSSQGSPSQGSPSQESPSQGSTSQASPSHRNTI----GVIGTTSSPKA 740

Query: 190 TDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 240
           T     ++H      T G   L   P + +  S     + P   E  TG F
Sbjct: 741 TG----STHSFPPGATDGPLAL---PGQLQGNSIMEPPSWPSPTEDPTGHF 784


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/189 (21%), Positives = 84/189 (44%), Gaps = 31/189 (16%)

Query: 371 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 424
           Y+  E+E+E+ D    S++ +       RRD L ++L N+   + L  + +   QR +EE
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382

Query: 425 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 471
            ++++  +   ++  +  QR   EE              EQR   +++   EE+  + E 
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442

Query: 472 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 522
           ++   RK       AE   R++ +  +Y+    S  + R+  +P  +         ++P+
Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499

Query: 523 DKAAIRKEL 531
           +K A  KE+
Sbjct: 500 EKPAWAKEI 508


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.124    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,737,727
Number of Sequences: 37866
Number of extensions: 1219457
Number of successful extensions: 15291
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 254
Number of HSP's successfully gapped in prelim test: 913
Number of HSP's that attempted gapping in prelim test: 9643
Number of HSP's gapped (non-prelim): 4711
length of query: 554
length of database: 18,247,518
effective HSP length: 107
effective length of query: 447
effective length of database: 14,195,856
effective search space: 6345547632
effective search space used: 6345547632
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.