Search of human proteins with 154354970

Search of human proteins with 154354970

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo
sapiens]
         (565 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo s...  1111   0.0  
gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo s...  1083   0.0  
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s...   975   0.0  
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s...   946   0.0  
gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa...   293   4e-79
gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa...   291   1e-78
gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo s...   279   4e-75
gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo s...   279   4e-75
gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]          270   3e-72
gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sa...   224   2e-58
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         54   5e-07
gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sap...    53   8e-07
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    52   1e-06
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    52   2e-06
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    50   4e-06
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             50   6e-06
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    49   9e-06
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    49   9e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    49   9e-06
gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]                       47   4e-05
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        47   6e-05
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...    46   8e-05
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...    46   8e-05
gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens]           46   8e-05
gi|92859701 myosin VI [Homo sapiens]                                   46   8e-05
gi|195976782 Paf1/RNA polymerase II complex component [Homo sapi...    46   8e-05
gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo sap...    46   1e-04
gi|118498337 HECT domain containing 1 [Homo sapiens]                   45   1e-04
gi|145580582 uromodulin-like 1 isoform 2 precursor [Homo sapiens]      45   2e-04
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...    45   2e-04

>gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo
           sapiens]
          Length = 565

 Score = 1111 bits (2874), Expect = 0.0
 Identities = 565/565 (100%), Positives = 565/565 (100%)

Query: 1   MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKK 60
           MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKK
Sbjct: 1   MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKK 60

Query: 61  KTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEES 120
           KTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEES
Sbjct: 61  KTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEES 120

Query: 121 TREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKA 180
           TREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKA
Sbjct: 121 TREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKA 180

Query: 181 SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 240
           SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV
Sbjct: 181 SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 240

Query: 241 PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 300
           PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD
Sbjct: 241 PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 300

Query: 301 PSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSA 360
           PSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSA
Sbjct: 301 PSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSA 360

Query: 361 SEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSK 420
           SEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSK
Sbjct: 361 SEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSK 420

Query: 421 KELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKM 480
           KELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKM
Sbjct: 421 KELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKM 480

Query: 481 ELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRK 540
           ELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRK
Sbjct: 481 ELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRK 540

Query: 541 ELNEFKSTEMEVHEESRQFTRFHRP 565
           ELNEFKSTEMEVHEESRQFTRFHRP
Sbjct: 541 ELNEFKSTEMEVHEESRQFTRFHRP 565


>gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo
           sapiens]
          Length = 554

 Score = 1083 bits (2800), Expect = 0.0
 Identities = 550/551 (99%), Positives = 551/551 (100%)

Query: 15  SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 74
           +VDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE
Sbjct: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63

Query: 75  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 134
           RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG
Sbjct: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123

Query: 135 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 194
           SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT
Sbjct: 124 SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 183

Query: 195 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 254
           TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM
Sbjct: 184 TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 243

Query: 255 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT 314
           VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT
Sbjct: 244 VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRT 303

Query: 315 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS 374
           TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS
Sbjct: 304 TLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDS 363

Query: 375 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE 434
           DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE
Sbjct: 364 DSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSE 423

Query: 435 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP 494
           EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP
Sbjct: 424 EERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRP 483

Query: 495 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE 554
           TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE
Sbjct: 484 TVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHE 543

Query: 555 ESRQFTRFHRP 565
           ESRQFTRFHRP
Sbjct: 544 ESRQFTRFHRP 554


>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
           sapiens]
          Length = 645

 Score =  975 bits (2520), Expect = 0.0
 Identities = 521/645 (80%), Positives = 536/645 (83%), Gaps = 80/645 (12%)

Query: 1   MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKK 60
           MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKK
Sbjct: 1   MGQTSVSTLSPQPGSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKK 60

Query: 61  KTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEES 120
           KTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEES
Sbjct: 61  KTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEES 120

Query: 121 TREENVVKSEEGNGSVSEKTPPLEEQAEDKK----------------------------- 151
           TREENVVKSEEGNGSVSEKTPPLEEQAEDKK                             
Sbjct: 121 TREENVVKSEEGNGSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKP 180

Query: 152 -----------AGSSH----------SKKTTGSKA------SASPSTSSTSSRPKASKET 184
                      AG+SH          + K  G +A       AS +T+  ++    SK+T
Sbjct: 181 KKSPVPPKGATAGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKT 240

Query: 185 VSSKAG---TVGTTKGKRKTDKQPITSHLSSDTTTSG---------------------TS 220
             SKA    +  +T  + K  K+ ++S   +  TT G                     TS
Sbjct: 241 TGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTS 300

Query: 221 DLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITA 280
           DLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITA
Sbjct: 301 DLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITA 360

Query: 281 SDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGK 340
           SDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGK
Sbjct: 361 SDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGK 420

Query: 341 TVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESAL 400
           TVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESAL
Sbjct: 421 TVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESAL 480

Query: 401 ASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEE 460
           ASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEE
Sbjct: 481 ASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEE 540

Query: 461 LEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYD 520
           LEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYD
Sbjct: 541 LEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYD 600

Query: 521 RRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
           RRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP
Sbjct: 601 RRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 645


>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
           sapiens]
          Length = 634

 Score =  946 bits (2446), Expect = 0.0
 Identities = 506/631 (80%), Positives = 522/631 (82%), Gaps = 80/631 (12%)

Query: 15  SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 74
           +VDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE
Sbjct: 4   AVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLE 63

Query: 75  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 134
           RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG
Sbjct: 64  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG 123

Query: 135 SVSEKTPPLEEQAEDKK----------------------------------------AGS 154
           SVSEKTPPLEEQAEDKK                                        AG+
Sbjct: 124 SVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGA 183

Query: 155 SH----------SKKTTGSKA------SASPSTSSTSSRPKASKETVSSKAG---TVGTT 195
           SH          + K  G +A       AS +T+  ++    SK+T  SKA    +  +T
Sbjct: 184 SHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSST 243

Query: 196 KGKRKTDKQPITSHLSSDTTTSG---------------------TSDLKGEPAETRVESF 234
             + K  K+ ++S   +  TT G                     TSDLKGEPAETRVESF
Sbjct: 244 SSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESF 303

Query: 235 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL 294
           KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL
Sbjct: 304 KLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADL 363

Query: 295 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 354
           PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES
Sbjct: 364 PVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 423

Query: 355 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL 414
           SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL
Sbjct: 424 SESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKL 483

Query: 415 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE 474
           GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE
Sbjct: 484 GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEE 543

Query: 475 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD 534
           EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD
Sbjct: 544 EQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPAD 603

Query: 535 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
           KAAIRKELNEFKSTEMEVHEESRQFTRFHRP
Sbjct: 604 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 634


>gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
           sapiens]
          Length = 559

 Score =  293 bits (749), Expect = 4e-79
 Identities = 207/571 (36%), Positives = 301/571 (52%), Gaps = 48/571 (8%)

Query: 5   SVSTLSPQPG-SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTS 63
           S +T S   G + D +D+   A  +   +G +TPP +R  KL+T+G+IFKPWKWRKKK +
Sbjct: 27  SSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-N 85

Query: 64  DKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTRE 123
           +K ++T++ LE+K++ RQ REELI++G+L E+ +QD +      +     +     + + 
Sbjct: 86  EKLKQTTSALEKKMAGRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKS 144

Query: 124 ENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKE 183
           E +   +   GS      PL    +        S       A+  PS SS          
Sbjct: 145 ETLTSEDAQPGS------PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE------- 191

Query: 184 TVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA 243
              + AG++            P T+ LS     + + D    P E  V        +P  
Sbjct: 192 ---ADAGSL-----------LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTP 237

Query: 244 EEQNTGKF-KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPS 302
             + + K  K++     +  A S  +    L  Q  T + +P  L +V   LP S +   
Sbjct: 238 PPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-E 295

Query: 303 QLLWAEEPTNRTTLYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESF 358
           +L  A    +R   + G    G    R + +   T   E GK   +  +     E+  + 
Sbjct: 296 ELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTA 355

Query: 359 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLG 415
           +   +E       N    D  +LY       +DE+   +S ++  + R+   + LA+KL 
Sbjct: 356 AKESEENKENLIINSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLR 408

Query: 416 NRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEE 475
           NRPSK+ELED+NI  R ++EERQEIRQQI  KL +RLSQRP  EELE+RNILKQ+N++ E
Sbjct: 409 NRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTE 468

Query: 476 QEAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPAD 534
           QE + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV  + DYDRRADKPW RL+ AD
Sbjct: 469 QEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAAD 528

Query: 535 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
           KAAIRKELNE+KS EMEVH  S+  TRFHRP
Sbjct: 529 KAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559


>gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo
           sapiens]
          Length = 518

 Score =  291 bits (744), Expect = 1e-78
 Identities = 202/556 (36%), Positives = 294/556 (52%), Gaps = 47/556 (8%)

Query: 19  LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 78
           +D+   A  +   +G +TPP +R  KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 1   MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59

Query: 79  TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSE 138
            RQ REELI++G+L E+ +QD +      +     +     + + E +   +   GS   
Sbjct: 60  GRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGS--- 115

Query: 139 KTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGK 198
              PL    +        S       A+  PS SS             + AG++      
Sbjct: 116 ---PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE----------ADAGSL------ 156

Query: 199 RKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMVPP 257
                 P T+ LS     + + D    P E  V        +P    + + K  K++   
Sbjct: 157 -----LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQ 211

Query: 258 PPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLY 317
             +  A S  +    L  Q  T + +P  L +V   LP S +   +L  A    +R   +
Sbjct: 212 ATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQDSF 269

Query: 318 SGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQAND 373
            G    G    R + +   T   E GK   +  +     E+  + +   +E       N 
Sbjct: 270 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 329

Query: 374 SDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNILQ 430
              D  +LY       +DE+   +S ++  + R+   + LA+KL NRPSK+ELED+NI  
Sbjct: 330 ELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 382

Query: 431 RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKL 490
           R ++EERQEIRQQI  KL +RLSQRP  EELE+RNILKQ+N++ EQE + E+K+RL+RKL
Sbjct: 383 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 442

Query: 491 SLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTE 549
           + RPTV EL+ R+IL RF++YVEV  + DYDRRADKPW RL+ ADKAAIRKELNE+KS E
Sbjct: 443 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 502

Query: 550 MEVHEESRQFTRFHRP 565
           MEVH  S+  TRFHRP
Sbjct: 503 MEVHASSKHLTRFHRP 518


>gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo
           sapiens]
          Length = 712

 Score =  279 bits (714), Expect = 4e-75
 Identities = 192/462 (41%), Positives = 258/462 (55%), Gaps = 29/462 (6%)

Query: 114 IPIGEESTREENVVKSE-----EGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 168
           IP  + + R  N V +E          +S+ +PPL      K+   S S  T  S A+ +
Sbjct: 270 IPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPP----KRGIPSTSVPTLESAAAIT 325

Query: 169 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE 228
             T      P   +E  +   G+        ++   P+ +H+  +   +     K     
Sbjct: 326 TKT------PSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVV 379

Query: 229 TRVE---SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 285
             +E   S  L Q +P  E+Q     K ++      P      PPLPL  +   A  +P+
Sbjct: 380 PEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPL 439

Query: 286 VLVSV--GADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVP 343
            +  +  G+    S L  +   ++E+ +   TL     L +  E  K    +EE  +T P
Sbjct: 440 PMTPILEGSHRAHSLLFENSDSFSEDSS---TLGRTRSLPITIEMLKVPDDEEEEEQTCP 496

Query: 344 QLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASK 403
              +   M  +S      +     E + +DSDS+GPI Y D+EDEDE    S +SALA+K
Sbjct: 497 STFSEE-MTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDE----SYQSALANK 551

Query: 404 IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQ 463
           ++R+DTLA+KL +RPS+ EL + N     S+EE  EIR QIG  L+RRLSQRPT EELEQ
Sbjct: 552 VKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ 610

Query: 464 RNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRA 523
           RNIL+ KNE + Q  K E+KRRL+RKLS RPTVAEL AR+ILRFNEYVEVTD+ DYDRRA
Sbjct: 611 RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA 670

Query: 524 DKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
           DKPW +LTPADKAAIRKELNEFKS+EMEVHEES+ FTR+HRP
Sbjct: 671 DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 712



 Score =  129 bits (323), Expect = 9e-30
 Identities = 114/370 (30%), Positives = 163/370 (44%), Gaps = 33/370 (8%)

Query: 1   MGQTSVSTLSPQPGSVDGLDKASIANS---DGPTAGSQTPPFKRKGKLSTIGKIFKPWKW 57
           MGQ  VS     P +V+  D+ +       D   AG  TPP KRK K S  GKIFKPWKW
Sbjct: 1   MGQADVSR-PVNPDAVEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKW 59

Query: 58  RKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENS---NGHMI 114
           RKKK+SDKF+ETS VLERKIS R+ REEL++RGVL E P+Q G+      ++   NGH  
Sbjct: 60  RKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTT 119

Query: 115 PIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS--------KAS 166
           PIG  + R  + V+ EE    ++     + E+   K+ GS+ S+  + +        K  
Sbjct: 120 PIG--NARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPP 177

Query: 167 ASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEP 226
             P     SS  +AS+        + GT +    T      +  ++ T+ + T +L   P
Sbjct: 178 LLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTP 237

Query: 227 AETRVESFKLEQTVPGA-EEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 285
           +          +T+P A    NT    S+    P    P P   P       + A  +  
Sbjct: 238 SPA-------PRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQA 290

Query: 286 VLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGL-----SVNRENAKCFTTKEELGK 340
           +        P   L P + +     T+  TL S   +     S  RE + C    E L  
Sbjct: 291 INSGTLLSKPSPPLPPKRGI---PSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPM 347

Query: 341 TVPQLLTPGL 350
             P+  +P L
Sbjct: 348 ISPRSPSPPL 357


>gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo
           sapiens]
          Length = 702

 Score =  279 bits (714), Expect = 4e-75
 Identities = 192/462 (41%), Positives = 258/462 (55%), Gaps = 29/462 (6%)

Query: 114 IPIGEESTREENVVKSE-----EGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 168
           IP  + + R  N V +E          +S+ +PPL      K+   S S  T  S A+ +
Sbjct: 260 IPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPP----KRGIPSTSVPTLESAAAIT 315

Query: 169 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE 228
             T      P   +E  +   G+        ++   P+ +H+  +   +     K     
Sbjct: 316 TKT------PSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVV 369

Query: 229 TRVE---SFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPV 285
             +E   S  L Q +P  E+Q     K ++      P      PPLPL  +   A  +P+
Sbjct: 370 PEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPL 429

Query: 286 VLVSV--GADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVP 343
            +  +  G+    S L  +   ++E+ +   TL     L +  E  K    +EE  +T P
Sbjct: 430 PMTPILEGSHRAHSLLFENSDSFSEDSS---TLGRTRSLPITIEMLKVPDDEEEEEQTCP 486

Query: 344 QLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASK 403
              +   M  +S      +     E + +DSDS+GPI Y D+EDEDE    S +SALA+K
Sbjct: 487 STFSEE-MTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDE----SYQSALANK 541

Query: 404 IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQ 463
           ++R+DTLA+KL +RPS+ EL + N     S+EE  EIR QIG  L+RRLSQRPT EELEQ
Sbjct: 542 VKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQ 600

Query: 464 RNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRA 523
           RNIL+ KNE + Q  K E+KRRL+RKLS RPTVAEL AR+ILRFNEYVEVTD+ DYDRRA
Sbjct: 601 RNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRA 660

Query: 524 DKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
           DKPW +LTPADKAAIRKELNEFKS+EMEVHEES+ FTR+HRP
Sbjct: 661 DKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 702



 Score =  126 bits (316), Expect = 6e-29
 Identities = 106/340 (31%), Positives = 151/340 (44%), Gaps = 29/340 (8%)

Query: 28  DGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELI 87
           D   AG  TPP KRK K S  GKIFKPWKWRKKK+SDKF+ETS VLERKIS R+ REEL+
Sbjct: 20  DSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELV 79

Query: 88  RRGVLKELPDQDGDVTVNFENS---NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLE 144
           +RGVL E P+Q G+      ++   NGH  PIG  + R  + V+ EE    ++     + 
Sbjct: 80  KRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIG--NARSSSPVQVEEEPVRLASLRKAIP 137

Query: 145 EQAEDKKAGSSHSKKTTGS--------KASASPSTSSTSSRPKASKETVSSKAGTVGTTK 196
           E+   K+ GS+ S+  + +        K    P     SS  +AS+        + GT +
Sbjct: 138 EEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTAR 197

Query: 197 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA-EEQNTGKFKSMV 255
               T      +  ++ T+ + T +L   P+          +T+P A    NT    S+ 
Sbjct: 198 FIISTSITTAPAATTAATSLAKTVNLSVTPSPA-------PRTLPAAPASTNTTATPSLT 250

Query: 256 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 315
              P    P P   P       + A  +  +        P   L P + +     T+  T
Sbjct: 251 HMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGI---PSTSVPT 307

Query: 316 LYSGTGL-----SVNRENAKCFTTKEELGKTVPQLLTPGL 350
           L S   +     S  RE + C    E L    P+  +P L
Sbjct: 308 LESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPL 347


>gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
          Length = 580

 Score =  270 bits (689), Expect = 3e-72
 Identities = 144/210 (68%), Positives = 171/210 (81%), Gaps = 6/210 (2%)

Query: 362 EDEGHREYQANDSD-SDGPILYT---DDEDEDEDEDGS-GESALASKIRRRDTLAIKLGN 416
           E + ++E   ++SD  D   LYT   ++E+EDED+D S   S+LA K+ R+D+LAIKL N
Sbjct: 371 ECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSN 430

Query: 417 RPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQ 476
           RPSK+ELE+KNIL R ++EER E+RQQIGTKL RRLSQRPT EELEQRNILK +NE+EEQ
Sbjct: 431 RPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQ 490

Query: 477 EAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADK 535
           E K E+KRRL+RKLS RPTV EL+ R+IL RF++YVEV D+ DYDRRADKPW RLT ADK
Sbjct: 491 EEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADK 550

Query: 536 AAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
           AAIRKELNEFKSTEMEVHE SR  TRFHRP
Sbjct: 551 AAIRKELNEFKSTEMEVHELSRHLTRFHRP 580



 Score =  112 bits (279), Expect = 1e-24
 Identities = 51/97 (52%), Positives = 74/97 (76%), Gaps = 1/97 (1%)

Query: 14  GSVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVL 73
           G+ + +++ +   SD    G+ TPP +R+ K + +G+IFKPWKWRKKK S+KF+ TSA L
Sbjct: 82  GAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKK-SEKFKHTSAAL 140

Query: 74  ERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSN 110
           ERKIS RQSREELI+RGVLKE+ D+DG+++++ E  +
Sbjct: 141 ERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDS 177



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 26/170 (15%)

Query: 345 LLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKI 404
           LL P LM  SSE     +D   R  +   S SD P L    E       G+ E       
Sbjct: 41  LLPPTLMAASSE-----DDIDRRPIRRVRSKSDTPYLA---EARISFNLGAAEEVERLAA 92

Query: 405 RRRDTLAIKLGNRPSKKELEDKNILQRTS----EEERQEIRQQIGTKLVRRLSQRPTTEE 460
            R D+L       P ++  +  N+ +        +++ E  +     L R++S R + EE
Sbjct: 93  MRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREE 152

Query: 461 LEQRNILKQ----------KNEEEEQEAKMELKRRLSRKLSLRPTVAELQ 500
           L +R +LK+           NEE+  E    L    S +LSL P ++E++
Sbjct: 153 LIKRGVLKEIYDKDGELSISNEEDSLENGQSLS---SSQLSL-PALSEME 198


>gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo
           sapiens]
          Length = 448

 Score =  224 bits (571), Expect = 2e-58
 Identities = 120/208 (57%), Positives = 152/208 (73%), Gaps = 4/208 (1%)

Query: 359 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRP 418
           +A E E ++E    +S+    +L   DE+   D   SG      K   ++ LA+KL NRP
Sbjct: 244 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK---KELLAVKLRNRP 300

Query: 419 SKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEA 478
           SK+ELED+NI  R ++EERQEIRQQI  KL +RLSQRP  EELE+RNILKQ+N++ EQE 
Sbjct: 301 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE 360

Query: 479 KMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAA 537
           + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV  + DYDRRADKPW RL+ ADKAA
Sbjct: 361 RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAA 420

Query: 538 IRKELNEFKSTEMEVHEESRQFTRFHRP 565
           IRKELNE+KS EMEVH  S+  TRFHRP
Sbjct: 421 IRKELNEYKSNEMEVHASSKHLTRFHRP 448



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 14/172 (8%)

Query: 19  LDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKIS 78
           +D+   A  +   +G +TPP +R  KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K++
Sbjct: 1   MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKKMA 59

Query: 79  TRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEE------- 131
            RQ REELI++G+L E+ +QD + +       G      E  T +   + SE+       
Sbjct: 60  GRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPL 117

Query: 132 --GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKAS 181
             G   VS    PL   A    AG +   + +  K SA PS     S P  S
Sbjct: 118 ATGTDQVS-LDKPLSSAAHLDDAGQATLFQASSMK-SADPSLRGQLSTPTGS 167


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 42/164 (25%), Positives = 68/164 (41%), Gaps = 10/164 (6%)

Query: 117  GEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSS 176
            G E+  EE   K+ +G      +            A SS S  ++ S +S+S S+SS+SS
Sbjct: 2578 GSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSS 2637

Query: 177  RPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKL 236
               +S  + SS + +  ++     +     +S  ++D  +S +SD +  PA T   S   
Sbjct: 2638 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPS--A 2695

Query: 237  EQTVPGAEEQNTGKF--------KSMVPPPPVAPAPSPLAPPLP 272
            +  +P    +  GK         K    P P AP P P  P  P
Sbjct: 2696 QAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQP 2739



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 52/187 (27%), Positives = 80/187 (42%), Gaps = 11/187 (5%)

Query: 93   KELPDQDG--DVTVNFENSNGHMIPIGEESTREENVVKSEEG--NGSVSEKTPPLEEQAE 148
            K   +QDG  +   +  +S+G        S+        EEG  NG     T      A 
Sbjct: 2546 KAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAA 2605

Query: 149  DKKAGS--SHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPI 206
              +A S  S S  ++ S +S+S S+SS+SS   +S  + SS + +  ++     +     
Sbjct: 2606 SSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2665

Query: 207  TSHLSS--DTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFK-SMVPPPPVAPA 263
            +S  SS  D  +S +SD +  PA T   S   +  +P    +  GK + S   P    PA
Sbjct: 2666 SSSSSSTTDEDSSCSSDDEAAPAPTAGPS--AQAALPTKATKQAGKARPSAHSPGKKTPA 2723

Query: 264  PSPLAPP 270
            P P APP
Sbjct: 2724 PQPQAPP 2730



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 11/188 (5%)

Query: 89   RGVLKELPDQDGDVTVNFENSNGHMIPIGE-ESTREENVVKSEEGNGSVSEKTPPLEEQA 147
            RG+L +L D    +TV F++ +   IP+        +  ++  E + ++   +     + 
Sbjct: 2248 RGLL-DLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRK 2306

Query: 148  EDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPIT 207
              K  G      T GS+   +       +R +  K +  +K     T +    TD+ P T
Sbjct: 2307 TSKDTGEGKDGGTAGSEEPGA------KARGRGRKPSAKAKGDRAATLEEGNPTDEVPST 2360

Query: 208  SHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVA--PAPS 265
                  ++T G+     EP + R ++ K  +  P         F S   P P A  PAP+
Sbjct: 2361 PLALEPSSTPGSKKSPPEPVDKRAKAPK-ARPAPPQPSPAPPAFTSCPAPEPFAELPAPA 2419

Query: 266  PLAPPLPL 273
                P PL
Sbjct: 2420 TSLAPAPL 2427


>gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo
           sapiens]
          Length = 373

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 41/208 (19%), Positives = 91/208 (43%), Gaps = 23/208 (11%)

Query: 365 GHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELE 424
           GH+ +Q ++ D DG      D++ED DED     A  + +R  +          S+   E
Sbjct: 71  GHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQE 130

Query: 425 DKNILQ--------------RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNIL--- 467
           ++  ++                 +EER  ++ +   +L ++L +R   EE E+R I+   
Sbjct: 131 EQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE 190

Query: 468 ------KQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDR 521
                 ++KNE++ +E + ++ + +  K +       LQ +   ++ E+++  ++ + +R
Sbjct: 191 KHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECER 250

Query: 522 RADKPWARLTPADKAAIRKELNEFKSTE 549
           +  +         +   +KE+ E K  E
Sbjct: 251 KKKEKEKEKQQQAEIQEKKEIAEKKFQE 278


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 27/212 (12%)

Query: 362 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 421
           +DE   EY  ++ + +       +  E E E  S  +       RRD L ++  N+   +
Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 422 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 476
            L  + +LQ     E++E ++Q+  +  +R+ Q     R   E+  +    +++ E E++
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 477 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLT 531
             + E KRRL      RK       AE + RR+ R  EY+         R+ ++    L 
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR--------RQLEEEQRHLE 480

Query: 532 PADKAAIRKE--LNEFKSTEMEVHEESRQFTR 561
              +  ++++  L E +  EME H ++ +  R
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 108/500 (21%), Positives = 179/500 (35%), Gaps = 105/500 (21%)

Query: 21  KASIANSDGPTAGSQTPPFKRKGKLSTIGKIF------KPWKWRKKKTSDKFRETSAVLE 74
           KA  ++SD  ++    PP  +K K++ +          KP +   K  + K   +S+   
Sbjct: 163 KAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSS 222

Query: 75  RKISTRQSREELIRRGVLKELPDQD-------GDVTVNFENSNGHMIPIGEESTREENVV 127
              S+  S EE       K +P +           T     S+       +E   ++  +
Sbjct: 223 SSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPM 282

Query: 128 KSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTT-------GSKASASPSTSSTSSRPKA 180
           K++ G  S     PP       K  G+   KK          S+ S+  S SS+    K 
Sbjct: 283 KNKPGPYS---SVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339

Query: 181 SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 240
             + V SKA    TTK      K   +S  SSD+ +S   +   +PA             
Sbjct: 340 PTKAVVSKA----TTK-PPPAKKAAESSSDSSDSDSSEDDEAPSKPA------------- 381

Query: 241 PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 300
            G  + ++ K       P V PA +P  P                  V  G  L     D
Sbjct: 382 -GTTKNSSNKPAVTTKSPAVKPAAAPKQP------------------VGGGQKLLTRKAD 422

Query: 301 PSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSA 360
            S    +EE ++                    +++EE  K +     P    +++ S  A
Sbjct: 423 SSS---SEEESS--------------------SSEEEKTKKMVATTKPKATAKAALSLPA 459

Query: 361 SE-DEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPS 419
            +  +G R     DS SD     +D    +E+E+ + +SA+  K ++     +  G  PS
Sbjct: 460 KQAPQGSR-----DSSSD-----SDSSSSEEEEEKTSKSAVKKKPQK-----VAGGAAPS 504

Query: 420 KKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPT------TEELEQRNILKQKNEE 473
           K     K   + ++     +  ++   KL  + S RP       T  L  +N    KN E
Sbjct: 505 KPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSE 564

Query: 474 EEQEAKMELKRRLSRKLSLR 493
           EE+E K +    +S+  SL+
Sbjct: 565 EEEEEKKKAAVVVSKSGSLK 584


>gi|238624188 diffuse panbronchiolitis critical region 1 protein
           [Homo sapiens]
          Length = 1393

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 79/368 (21%), Positives = 131/368 (35%), Gaps = 38/368 (10%)

Query: 58  RKKKTSDKFRETSAVLERKIST--------------RQSREELIRRGVLKELPDQDGDVT 103
           R  K +DK    S  ++ K ST               Q ++ +IR    + +   D   T
Sbjct: 91  RHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQ--RSVDPADSTTT 148

Query: 104 VNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP----PLEEQAEDKKAGSSHSKK 159
                   H+ P  +      N  KS  G  +V+ K+     PLE+        S+ S K
Sbjct: 149 HKESAGKKHITPAPKSKI---NCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHK 205

Query: 160 TTGSKASASPSTSSTSSRPKASKETVSSKAG--TVGTTKGKRKTDKQPITSHLSSDTTTS 217
           TT S  ++  S +   S     K T +SK    T GT +   KT+    T+  S    T 
Sbjct: 206 TTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSR-TTVASDKLLTK 264

Query: 218 GTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPP----VAPAPSPLAPPLPL 273
            T +++   +   +     E T  G    N     S   P       A   + L+P  P+
Sbjct: 265 TTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPI 324

Query: 274 EDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT--------NRTTLYSGTGLSVN 325
           E++  TA++      +   +      + +  L+  EPT          TT          
Sbjct: 325 ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG 384

Query: 326 RENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 385
              A   TT      T     TP    +++ S + S + G R   AN++ +  P   T++
Sbjct: 385 ERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTEN 444

Query: 386 EDEDEDED 393
            +   +E+
Sbjct: 445 RERTANEN 452



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 71/320 (22%), Positives = 116/320 (36%), Gaps = 50/320 (15%)

Query: 110 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASP 169
           +G   P+  E+T       +E    + +EKT P   +  + +  +++   T     S + 
Sbjct: 703 HGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANENTT----PSPAQ 758

Query: 170 STSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTT---------TSGTS 220
            T +    P A+++T  S A    T  GKR       T+  S++ T            T+
Sbjct: 759 PTENGDRTPLANEKTTPSLAEP--TENGKRTPFANEKTTSSSAEPTEHAERTPLANENTT 816

Query: 221 DLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITA 280
               EP E R  +   + T   AE     +  +     P         P  P E++  TA
Sbjct: 817 SSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPF--------PAEPTENREWTA 868

Query: 281 SDTPVVLVSVGADLPVSALDPSQLLWAEEPT---NRTTLYSGTGLSVNRENAKCFTTKEE 337
           ++              + L P++    EE T   N  T  S    + N E    FT +  
Sbjct: 869 NEN-------------TTLSPAEPTEHEEMTPLANEKTTLSPAEPTENGERTP-FTNE-- 912

Query: 338 LGKTVPQLLTPGLMGESS------ESFSASEDEGHREYQANDSDSDGPILYTDDEDEDED 391
             KT P    P   GE +       + S +E   H E  AN+  +  P   T+  +   +
Sbjct: 913 --KTTPSSAEPTEHGERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVN 970

Query: 392 EDGSGESALASKIRRRDTLA 411
           ED +  SA  ++   R  LA
Sbjct: 971 EDTTPSSAEPTENGERTPLA 990



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 65/287 (22%), Positives = 108/287 (37%), Gaps = 38/287 (13%)

Query: 110 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS-KASAS 168
           +G   P+  E+T       +E    + +E T P         AG + +++TT + K + S
Sbjct: 423 HGERTPLANENTTPSPAEPTENRERTANENTTP-------SPAGPTENRETTANEKTTLS 475

Query: 169 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG---------T 219
           P   + +    A+++T  S A    T  G+R       T+  S++ T  G         T
Sbjct: 476 PVEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTPLANENT 533

Query: 220 SDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCIT 279
           +    EP E R E    E+T P   E      ++ +      P+   LA P     +   
Sbjct: 534 TPSPAEPTENR-ERTANEKTTPSPAEPTENGDRTPLANEKTTPS---LAEPTENGQRTPF 589

Query: 280 ASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRE-NAKCFTTKEEL 338
           A++              S+ +P++        N  T  S    + NRE  A   TT    
Sbjct: 590 ANEKTT----------SSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 639

Query: 339 GKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 385
           G T  + +T     E +  F A   E +RE  AN+  +  P   T++
Sbjct: 640 GPTENREMT---ANEKTTLFPAEPTE-NRERTANEKTTSSPAEPTEN 682



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 56/300 (18%), Positives = 112/300 (37%), Gaps = 34/300 (11%)

Query: 119 ESTREENVVKSEEGNGSVSEKTPPLE-EQAEDKKAGSSHSKKTTGSKAS----------A 167
           E T    V  +E    + +EKT P   E  E+ +     ++KTT S A           A
Sbjct: 470 EKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 529

Query: 168 SPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPA 227
           + +T+ + + P  ++E  +++  T    +     D+ P+ +  ++ +    T + +  P 
Sbjct: 530 NENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP- 588

Query: 228 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVL 287
                 F  E+T   + E    + ++ +      P+P   A P    ++    + TP   
Sbjct: 589 ------FANEKTTSSSAEPTEHEERTPLANENTTPSP---AEPTENRERTANENTTPS-- 637

Query: 288 VSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT 347
                  P    +  ++   E    +TTL+           A   TT      T     T
Sbjct: 638 -------PAGPTENREMTANE----KTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 686

Query: 348 PGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR 407
           P    +++ S +   + G R   AN++ +  P   T++ +   +E  +   A  ++ R R
Sbjct: 687 PFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRER 746



 Score = 37.4 bits (85), Expect = 0.037
 Identities = 47/198 (23%), Positives = 79/198 (39%), Gaps = 44/198 (22%)

Query: 96   PDQDGDVTVNFENS--------NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPL-EEQ 146
            P + G+ TVN + +        NG   P+  E+T       +E G  + +EKT P   E 
Sbjct: 961  PTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTEHGERTANEKTTPSPAEP 1020

Query: 147  AEDKKAGSSHSKKTTGSKA----------SASPSTSSTSSRP--KASKETVSSKAGTV-- 192
             E  +   S ++KT  S A          SA+ +T+ +  +P     K T++++  T+  
Sbjct: 1021 TEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSP 1080

Query: 193  -GTTKGKRKTD--KQPITSHLSSDT-----TTSGTSDLKGEPAETRVESFKLEQTVPGAE 244
             G T+   KT    + IT  L+  T     TTS    +    AE+              E
Sbjct: 1081 EGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAES-------------TE 1127

Query: 245  EQNTGKFKSMVPPPPVAP 262
             ++     +++ P P  P
Sbjct: 1128 HRDRATSANVITPAPAEP 1145


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 104/553 (18%), Positives = 202/553 (36%), Gaps = 94/553 (16%)

Query: 75  RKISTRQSREELIRRGVLKELPDQDGDVTVNFENS----NGHMIPIG------------E 118
           +K + R   + L + G+ + +P      ++  EN     N +++P              E
Sbjct: 34  QKTTARHGLQSLGKVGISRRMPPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEE 93

Query: 119 ESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRP 178
           E T E    + + G  +  E  P  +  A +K+ G     +         PS  +   + 
Sbjct: 94  EKTPEVPPAQPKPGVAAPPEVAPAPKSWASNKQGGQGDGIQVNSQFQQEFPSLQAAGDQE 153

Query: 179 KASKETVSSKAG------------------TVGTTKGKRKTDKQPITSHLSSDTTTSGTS 220
           K  KET     G                    G+     + +K P       D +T+GTS
Sbjct: 154 KKEKETNDDNYGPGPSLRPPNVACWRDGGKAAGSPSSSDQDEKLP-----GQDESTAGTS 208

Query: 221 DLKG--EPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPL--PLEDQ 276
           +     +  E R+     +  + G +     ++++M+PP      P    PPL  P+   
Sbjct: 209 EQNDILKVVEKRIACGPPQAKLNGQQAALASQYRAMMPPYMFQQYPRMTYPPLHGPMR-- 266

Query: 277 CITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNR-ENAKCFTTK 335
                  P  L      L      PS   WA EP   + L +     +++ +N      +
Sbjct: 267 ------FPPSLSETNKGLRGRGPPPS---WASEPERPSILSASELKELDKFDNLDAEADE 317

Query: 336 EELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGS 395
              G  +    T  L      +FS  +++G    + N+S+  G     ++E++ E ++ S
Sbjct: 318 GWAGAQMEVDYTEQL------NFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVS 371

Query: 396 GESALASKIRRRDTLAIKLGNRPSKKELE---------DKNILQRTSEEERQEI------ 440
              + +    +     +  G  PS  +            K + Q+    +RQ +      
Sbjct: 372 NTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGP 431

Query: 441 ---RQQIGTK----LVRRLSQRPTTEELE----QRNILKQKNEEEEQEAKMELKRRLSRK 489
              +QQ+  +      RR  Q   +  +E    +R   +++ EE+ + A  E  +RL  K
Sbjct: 432 FPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEK 491

Query: 490 LSL---RPTVAELQARRILRFNE-YVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEF 545
           L +   +P+  E++ R   +  E   E+    + +R  ++   R    +K    KEL + 
Sbjct: 492 LGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEK---EKELEKE 548

Query: 546 KSTEMEVHEESRQ 558
           +  + E+ +E +Q
Sbjct: 549 QEKQREMEKERKQ 561



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/154 (25%), Positives = 72/154 (46%), Gaps = 21/154 (13%)

Query: 348 PGLMGE-SSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDE--DGSGESALASKI 404
           PG  G   S+   A EDE  ++ +   S+    +       E+E+   +   ++A A K+
Sbjct: 426 PGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKL 485

Query: 405 RRRDTLAIKLGNRPS---------KKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQR 455
           +R D     L  +PS         +KE E +  L++  E+ER++ R++       R  Q+
Sbjct: 486 KRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREK------DRERQQ 539

Query: 456 PTTEELEQRNILKQKNEEEEQEAKMELKRRLSRK 489
              +ELE+    ++K  E E+E K E ++ L R+
Sbjct: 540 EKEKELEKE---QEKQREMEKERKQEKEKELERQ 570



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 34/162 (20%), Positives = 63/162 (38%), Gaps = 19/162 (11%)

Query: 118 EESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSR 177
           +E  +E   +K +E    + ++   LEE+ E ++       +   S+ S +       +R
Sbjct: 571 KEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTR 630

Query: 178 PKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTS----------DLKGEPA 227
             +++   S K  T    + + ++  QP  + LS        S           +K +  
Sbjct: 631 QDSNR---SEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQW 687

Query: 228 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAP 269
           + + +   L QTVP     +T      VPPPP  P   P+ P
Sbjct: 688 QQQQQQGVLPQTVPSQPSSST------VPPPPHRPLYQPMQP 723



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 47/241 (19%), Positives = 90/241 (37%), Gaps = 40/241 (16%)

Query: 96   PDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNG-------SVSEKTPPLEEQAE 148
            P ++    V  + S    +  G   T++ +  +SE   G        +  K P    + +
Sbjct: 907  PQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEK 966

Query: 149  DKKAGSSHS------KKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTD 202
             KK G   S      +K   SK+        +S+R +   +    ++G +          
Sbjct: 967  PKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPI---------- 1016

Query: 203  KQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAP 262
            K+P+   +  +       + +GE AE   E   ++        + T K K + PPPP   
Sbjct: 1017 KKPVLRDMKEEREQR--KEKEGEKAEKVTEKVVVKP-------EKTEK-KDLPPPPPPPQ 1066

Query: 263  APSPLAP---PLPLEDQC----ITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 315
             P+P+ P   P P++ +      T + T     S   + P+  +   Q+  A +  N+ T
Sbjct: 1067 PPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQT 1126

Query: 316  L 316
            +
Sbjct: 1127 M 1127



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 7/126 (5%)

Query: 183  ETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAE------TRVESFKL 236
            E VS K       + +RK ++Q I      +    G S     P        T ++  + 
Sbjct: 1683 EVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGIQQAQS 1742

Query: 237  EQTVPG-AEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLP 295
              +VP  A         + VP    AP P+ L P        + AS    VL S  A +P
Sbjct: 1743 SASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVP 1802

Query: 296  VSALDP 301
             S L P
Sbjct: 1803 ASPLAP 1808


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis
           critical region 1 [Homo sapiens]
          Length = 1400

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 79/368 (21%), Positives = 130/368 (35%), Gaps = 38/368 (10%)

Query: 58  RKKKTSDKFRETSAVLERKIST--------------RQSREELIRRGVLKELPDQDGDVT 103
           R  K +DK    S  ++ K ST               Q ++ +IR    + +   D   T
Sbjct: 153 RHSKPTDKPTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQ--RSVDPADSTTT 210

Query: 104 VNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTP----PLEEQAEDKKAGSSHSKK 159
                   H+ P  +      N  KS  G  +V+ K+     PLE+        S+ S K
Sbjct: 211 HKESAGKKHITPAPKSKI---NCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHK 267

Query: 160 TTGSKASASPSTSSTSSRPKASKETVSSKAG--TVGTTKGKRKTDKQPITSHLSSDTTTS 217
           TT S  ++  S +   S     K T +SK    T GT +   KT+    T+  S    T 
Sbjct: 268 TTTSFHNSGNSQTKQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSR-TTVASDKLLTK 326

Query: 218 GTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPP----VAPAPSPLAPPLPL 273
            T +++   +   +     E T  G    N     S   P       A   + L+P  P 
Sbjct: 327 TTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPT 386

Query: 274 EDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPT--------NRTTLYSGTGLSVN 325
           E++  TA++      +   +      + +  L+  EPT          TT          
Sbjct: 387 ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHG 446

Query: 326 RENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 385
              A   TT      T     TP    +++ S + S + G R   AN++ +  P   T++
Sbjct: 447 ERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTEN 506

Query: 386 EDEDEDED 393
            +   +E+
Sbjct: 507 RERTANEN 514



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 65/287 (22%), Positives = 108/287 (37%), Gaps = 38/287 (13%)

Query: 110 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGS-KASAS 168
           +G   P+  E+T       +E    + +E T P         AG + +++TT + K + S
Sbjct: 485 HGERTPLANENTTPSPAEPTENRERTANENTTP-------SPAGPTENRETTANEKTTLS 537

Query: 169 PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSG---------T 219
           P   + +    A+++T  S A    T  G+R       T+  S++ T  G         T
Sbjct: 538 PVEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTPLANENT 595

Query: 220 SDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCIT 279
           +    EP E R E    E+T P   E      ++ +      P+   LA P     +   
Sbjct: 596 TPSPAEPTENR-ERTANEKTTPSPAEPTENGDRTPLANEKTTPS---LAEPTENGQRTPF 651

Query: 280 ASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRE-NAKCFTTKEEL 338
           A++              S+ +P++        N  T  S    + NRE  A   TT    
Sbjct: 652 ANEKTT----------SSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 701

Query: 339 GKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDD 385
           G T  + +T     E +  F A   E +RE  AN+  +  P   T++
Sbjct: 702 GPTENREMT---ANEKTTLFPAEPTE-NRERTANEKTTSSPAEPTEN 744



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 56/300 (18%), Positives = 112/300 (37%), Gaps = 34/300 (11%)

Query: 119 ESTREENVVKSEEGNGSVSEKTPPLE-EQAEDKKAGSSHSKKTTGSKAS----------A 167
           E T    V  +E    + +EKT P   E  E+ +     ++KTT S A           A
Sbjct: 532 EKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLA 591

Query: 168 SPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPA 227
           + +T+ + + P  ++E  +++  T    +     D+ P+ +  ++ +    T + +  P 
Sbjct: 592 NENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTP- 650

Query: 228 ETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVL 287
                 F  E+T   + E    + ++ +      P+P   A P    ++    + TP   
Sbjct: 651 ------FANEKTTSSSAEPTEHEERTPLANENTTPSP---AEPTENRERTANENTTPS-- 699

Query: 288 VSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT 347
                  P    +  ++   E    +TTL+           A   TT      T     T
Sbjct: 700 -------PAGPTENREMTANE----KTTLFPAEPTENRERTANEKTTSSPAEPTENGQRT 748

Query: 348 PGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR 407
           P    +++ S +   + G R   AN++ +  P   T++ +   +E  +   A  ++ R R
Sbjct: 749 PFANEKTTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRER 808



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 26/190 (13%)

Query: 110 NGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASP 169
           +G   P+  E+T       +E    + +EKT P   +  + +  +++   T     S + 
Sbjct: 765 HGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRERTANENTT----PSPAQ 820

Query: 170 STSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTT---------TSGTS 220
            T +    P A+++T  S A    T  GKR       T+  S++ T            T+
Sbjct: 821 PTENGDRTPLANEKTTPSLAEP--TENGKRTPFANEKTTSSSAEPTEHAERTPLANENTT 878

Query: 221 DLKGEPAETRVESFKLEQTVPGAE--EQNTGKFKSMVPPPPVAPAP---------SPLAP 269
               EP E R  +   + T   AE  E           P P  P           + L+P
Sbjct: 879 SSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSP 938

Query: 270 PLPLEDQCIT 279
             P E + +T
Sbjct: 939 AEPTEHEEMT 948



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 4/111 (3%)

Query: 129  SEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSK 188
            ++    ++S K      ++    A  + ++ TT S     P+T+ST+        TVSS 
Sbjct: 1197 TDSATTAISTKASGTTVESAPSTAPPTPAETTTASV----PTTTSTTGSENTGHHTVSSV 1252

Query: 189  AGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQT 239
              TV  T  +  T  +   +  S+   T+  +      +ET V S K   T
Sbjct: 1253 PTTVFATASESSTGSETTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVT 1303



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 8/131 (6%)

Query: 152  AGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLS 211
            A ++ S K +G+   ++PST+     P    ET ++   T  +T G   T    ++S  +
Sbjct: 1200 ATTAISTKASGTTVESAPSTA-----PPTPAETTTASVPTTTSTTGSENTGHHTVSSVPT 1254

Query: 212  SDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMV-PPPPVAPAPSPLAPP 270
            +   T+  S    E   TR  +   E T        TG   ++V    PV    S  +  
Sbjct: 1255 TVFATASESSTGSE--TTRASTSATEVTTAMTTAMTTGSETAVVSTKAPVTTTQSGFSTA 1312

Query: 271  LPLEDQCITAS 281
              +  +  TAS
Sbjct: 1313 TVMPAKTTTAS 1323



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 57/238 (23%), Positives = 89/238 (37%), Gaps = 32/238 (13%)

Query: 135  SVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGT 194
            +VSE         E   A ++ S  TT S  ++ P+T+STS     +    +    T+  
Sbjct: 1035 AVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKNTTACEATMSETTIAA 1094

Query: 195  TKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSM 254
                  T     TS +++++     +     P +T   S  +  TVP   + NT    + 
Sbjct: 1095 ITASEDTTVSTQTSVIAAESVPHTATK---TPTDTTTAS--VSATVP---KNNTLSVITS 1146

Query: 255  VPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWA--EEPTN 312
             P    + AP+  +  +       TAS T     S    LP +    +  + A  E PT 
Sbjct: 1147 TP----STAPNTASKTM------TTASKT--TTTSTITSLPTTVFTTTSKITAGSEIPTA 1194

Query: 313  RTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESS----ESFSASEDEGH 366
             TT  + T +S         TT E    T P   TP     +S     S + SE+ GH
Sbjct: 1195 STTDSATTAISTKASG----TTVESAPSTAPP--TPAETTTASVPTTTSTTGSENTGH 1246


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 17/160 (10%)

Query: 362 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 421
           +DE   EY  ++ + +       +  E E E  S  +       RRD L ++  N+   +
Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 422 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 476
            L  + +LQ     E++E ++Q+  +  +R+ Q     R   E+  +    +++ E E++
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 477 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYV 511
             + E KRRL      RK       AE + RR+ R  EY+
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 17/160 (10%)

Query: 362 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 421
           +DE   EY  ++ + +       +  E E E  S  +       RRD L ++  N+   +
Sbjct: 316 KDETEYEYSGSEEEEE-------EVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSE 368

Query: 422 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQ-----RPTTEELEQRNILKQKNEEEEQ 476
            L  + +LQ     E++E ++Q+  +  +R+ Q     R   E+  +    +++ E E++
Sbjct: 369 ALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQR 428

Query: 477 EAKMELKRRLS-----RKLSLRPTVAELQARRILRFNEYV 511
             + E KRRL      RK       AE + RR+ R  EY+
Sbjct: 429 RREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468


>gi|72256200 B-cell CLL/lymphoma 9 [Homo sapiens]
          Length = 1426

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 58/259 (22%), Positives = 105/259 (40%), Gaps = 32/259 (12%)

Query: 150 KKAGSSHSKKT-TGSKASASPSTSSTSSRPKASKETVSSKA---------------GTVG 193
           K   S H+  + T S A+A  S++ +  +  A++ T + K                    
Sbjct: 132 KSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEA 191

Query: 194 TTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQT--VPGAEEQNTGKF 251
             KG+ +T       ++S++ T   T+ L  + +  R +   L Q    P  ++QN+ + 
Sbjct: 192 VLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQN 251

Query: 252 KSMVPPPPV-APAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEP 310
             + P PP+ APAP P APP PL+ +     +   ++ SVG+    + L P        P
Sbjct: 252 TRLQPTPPIPAPAPKPAAPPRPLDRESPGVENK--LIPSVGSPASSTPLPPDGTGPNSTP 309

Query: 311 TNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLT--PGLMGESSESFSASEDEGHRE 368
            NR       G + +  + K            P + +  P  +GE+ +  S  + E HRE
Sbjct: 310 NNRAVTPVSQGSNSSSADPK--------APPPPPVSSGEPPTLGENPDGLSQEQLE-HRE 360

Query: 369 YQANDSDSDGPILYTDDED 387
                      +L+ D+++
Sbjct: 361 RSLQTLRDIQRMLFPDEKE 379


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 107/496 (21%), Positives = 176/496 (35%), Gaps = 70/496 (14%)

Query: 59   KKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGE 118
            K  + DK RE + +LE   S+R   +++I      +  D++     + EN     I    
Sbjct: 913  KVSSVDKQREQTEILE---SSRMRAQDIIGH---HQSEDRETSDRAHDENKKKAKIQKKP 966

Query: 119  ESTREENVVKSEEGN-GSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSR 177
               ++E+ V  E GN  + SE       +   KK      +K +   +  S   ++  S+
Sbjct: 967  IKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSK 1026

Query: 178  PKASKET--VSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFK 235
             K    T  +++K   V    GK    +    S    DT  S  SD   E    R E  +
Sbjct: 1027 KKRGPRTPPITTKEELVEMCNGKNGILED---SQKKEDTAFSDWSD---EDVPDRTEVTE 1080

Query: 236  LEQTVPGAEEQNTGKFKSMV--PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGAD 293
             E T       +T    S +  PPPPVA A               TA+  P  L +  A 
Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATA---------------TATTVPATLAATTAA 1125

Query: 294  LPVS-ALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMG 352
               S +     +  +  PTN T        +    + KC  T+ E  +T P +       
Sbjct: 1126 AATSFSTSAITISTSATPTNTTN----NTFANEDSHRKCHRTRVEKVET-PHVTIEDAQH 1180

Query: 353  ESSESFSASEDEGHREYQANDSDSDGPILY--TDDEDEDEDEDGSGESALASKIRRRD-T 409
                    S   G    ++N S + G +     D      D+    +  L S  R R+ T
Sbjct: 1181 RKPMDQKRSSSLGSN--RSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKT 1238

Query: 410  LAIKL-GNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILK 468
             ++++ G R S+ +   +    R++  +RQ+ R         R S   +  ++  R+   
Sbjct: 1239 KSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS-----RRSSPESDRQVHSRSGSF 1293

Query: 469  QKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWA 528
               +  ++  + E  R   R+            RR  R  E+         DR ADK W 
Sbjct: 1294 DSRDRLQERDRYEHDRERERE------------RRDTRQREW---------DRDADKDWP 1332

Query: 529  RLTPADKAAIRKELNE 544
            R    D+   R+   E
Sbjct: 1333 RNRDRDRLRERERERE 1348



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 35/173 (20%), Positives = 74/173 (42%), Gaps = 13/173 (7%)

Query: 49   GKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFEN 108
            G++F P K +KKK+ +K R+ S   +  IS  ++ ++  ++   +  P    +  V   N
Sbjct: 989  GQVFSPKKGQKKKSIEKKRKKSKG-DSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCN 1047

Query: 109  SNGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASAS 168
                ++   E+S ++E+   S+  +  V ++T   E         + H+   T   ++ S
Sbjct: 1048 GKNGIL---EDSQKKEDTAFSDWSDEDVPDRTEVTE---------AEHTATATTPGSTPS 1095

Query: 169  PSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSD 221
            P +S     P  +  T ++   T+  T     T        +S+  T + T++
Sbjct: 1096 PLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTN 1148



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 17/149 (11%)

Query: 58  RKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNF----------E 107
           RK+ +  + RE   +   K  T +S EE +     ++  D +GD+  ++          +
Sbjct: 113 RKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSD-NGDINYDYVHELSLEMKRQ 171

Query: 108 NSNGHMIPIGEEST--REENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKA 165
                ++ + +E+   REE ++K E     V  K  P     +  K+    S   + S +
Sbjct: 172 KIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSAS 231

Query: 166 SASPSTSSTSS----RPKASKETVSSKAG 190
                TS+ SS    + + SK   S K G
Sbjct: 232 KKDRKTSAVSSPLLDQQRNSKTNQSKKKG 260



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 42/201 (20%), Positives = 78/201 (38%), Gaps = 29/201 (14%)

Query: 362 EDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKK 421
           E +  RE +  D   D       + D + + D   E     + R RD        R  ++
Sbjct: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERER---ERERERDR------EREKER 705

Query: 422 ELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKME 481
           ELE +   +R  E E++  R++   +   R  +R    + E+    +++  E E+E + E
Sbjct: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERE 765

Query: 482 LKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKE 541
            +R   R+          + R   R  E     D  D D+  D         D+   R+E
Sbjct: 766 RERERERE----------RERARERDKERERQRDWEDKDKGRD---------DRREKREE 806

Query: 542 LNEFKSTEMEVHEESRQFTRF 562
           + E ++   + H+E +   R+
Sbjct: 807 IREDRNPR-DGHDERKSKKRY 826


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 42/191 (21%), Positives = 85/191 (44%), Gaps = 31/191 (16%)

Query: 382 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 435
           Y+  E+E+E+ D    S++ +       RRD L ++L N+   + L  + +   QR +EE
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382

Query: 436 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 482
            ++++  +   ++  +  QR   EE              EQR   +++   EE+  + E 
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442

Query: 483 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 533
           ++   RK       AE   R++ +  +Y+    S  + R+  +P  +         ++P+
Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499

Query: 534 DKAAIRKELNE 544
           +K A  KE+ E
Sbjct: 500 EKPAWAKEVEE 510


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 42/191 (21%), Positives = 85/191 (44%), Gaps = 31/191 (16%)

Query: 382 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 435
           Y+  E+E+E+ D    S++ +       RRD L ++L N+   + L  + +   QR +EE
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382

Query: 436 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 482
            ++++  +   ++  +  QR   EE              EQR   +++   EE+  + E 
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442

Query: 483 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 533
           ++   RK       AE   R++ +  +Y+    S  + R+  +P  +         ++P+
Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499

Query: 534 DKAAIRKELNE 544
           +K A  KE+ E
Sbjct: 500 EKPAWAKEVEE 510


>gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens]
          Length = 490

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 15/194 (7%)

Query: 24  IANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSR 83
           ++N D  T  S     K++ +     + F+  K RKKK     R+T++VL +     +S 
Sbjct: 268 VSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQA-RKTASVLSKDDVAPESG 326

Query: 84  EELIRRGVLK--ELPDQD------GDVTVNFENSNG----HMIPIGEESTREENVVKSEE 131
           +  +++   K  + P+        G   V   N +      ++PIG+++   E V   + 
Sbjct: 327 DTTVKKPESKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKH 386

Query: 132 GNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGT 191
             G  S    P       KK  +  + +T  +  S +P   S   +PK  +E V  K+ +
Sbjct: 387 ATGKKSPAKSPNPSTPRGKKRKALPASETPKAAESETPG-KSPEKKPKIKEEAVKEKSPS 445

Query: 192 VGTTKGKRKTDKQP 205
           +G  K  R+T K+P
Sbjct: 446 LG-KKDARQTPKKP 458


>gi|92859701 myosin VI [Homo sapiens]
          Length = 1285

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 52/224 (23%), Positives = 103/224 (45%), Gaps = 40/224 (17%)

Query: 335  KEELGKTVPQL-LTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDED 393
            K E+ K +  L ++   +    +S   ++++  +EY A    S+  +     + + E+E 
Sbjct: 864  KPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEE- 922

Query: 394  GSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLS 453
                   A ++RR   +  ++     ++E ++K   +R  EEE + ++ ++  K  +   
Sbjct: 923  -------AERLRR---IQEEMEKERKRREEDEK---RRRKEEEERRMKLEMEAKRKQEEE 969

Query: 454  QRPTTEELEQR-------NILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILR 506
            +R   E+ E+R        + +QK EE +Q+A +E +RR  R+L+LR   +E +      
Sbjct: 970  ERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERR-DRELALRIAQSEAEL----- 1023

Query: 507  FNEYVEVTDSPDYD---RRADKPWARLTPADKAAIRKELNEFKS 547
                  ++D    D   RR D    ++TP   A   KE++EF S
Sbjct: 1024 ------ISDEAQADLALRRNDGTRPKMTPEQMA---KEMSEFLS 1058


>gi|195976782 Paf1/RNA polymerase II complex component [Homo
           sapiens]
          Length = 710

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 47/196 (23%), Positives = 84/196 (42%), Gaps = 12/196 (6%)

Query: 325 NRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTD 384
           N+   K    K E   T+ +         SS+  S++E     E + +DSDS+     +D
Sbjct: 109 NKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDSNSSSSSSD 168

Query: 385 DEDEDEDE---DGSGESALASK--IRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQE 439
            +   EDE   DG GE  +  +    R + +  K   +     +E + +L+R     R E
Sbjct: 169 SDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVLKR-----RFE 223

Query: 440 IRQQIGT-KLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLR-PTVA 497
           I++++ T K   +  ++   EE +++  L Q  E +      E + +   KL  +   + 
Sbjct: 224 IKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLDKKSQAME 283

Query: 498 ELQARRILRFNEYVEV 513
           EL+A R  R N   E+
Sbjct: 284 ELKAEREKRKNRTAEL 299


>gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo
           sapiens]
          Length = 229

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/135 (23%), Positives = 60/135 (44%), Gaps = 14/135 (10%)

Query: 365 GHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELE 424
           GH+ +Q ++ D DG      D++ED DED     A  + +R  +          S+   E
Sbjct: 71  GHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQE 130

Query: 425 DKNILQ--------------RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQK 470
           ++  ++                 +EER  ++ +   +L ++L +R   EE E+R I+ ++
Sbjct: 131 EQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEE 190

Query: 471 NEEEEQEAKMELKRR 485
             +E  + K E  RR
Sbjct: 191 KHKEWVQKKNEQVRR 205


>gi|118498337 HECT domain containing 1 [Homo sapiens]
          Length = 2610

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 71/314 (22%), Positives = 122/314 (38%), Gaps = 47/314 (14%)

Query: 124  ENVVKSEEGNGS---VSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKA 180
            ENV ++E G+ S    S  T     +  ++K G   S +T G  ++ S    S SS   +
Sbjct: 1433 ENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVS 1492

Query: 181  SKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTV 240
            S          V     K    ++P++S  S+  + S      G P  +         +V
Sbjct: 1493 S----------VSELTNKEAASQRPLSSSASNRLSVSSLL-AAGAPMSSSA-------SV 1534

Query: 241  PGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALD 300
            P    + T   +S V         + +A      +  ++ S +     ++G ++  +A  
Sbjct: 1535 PNLSSRETSSLESFVR------RVANIARTNATNNMNLSRSSSDNNTNTLGRNVMSTATS 1588

Query: 301  PSQLLWAEE------PTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGES 354
            P  L+ A+       P   +T+   T    +  N    TT   +G+++   LT  L   S
Sbjct: 1589 P--LMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTS 1646

Query: 355  SESFSASEDEGHREYQANDS----------DSDGPILYTDDED-EDEDEDGSGESALASK 403
            SES +  E E +  Y   DS          D D  +   D+ED E+ED++   +      
Sbjct: 1647 SESDTGQEAE-YSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVM 1705

Query: 404  IRRRDTLAIKLGNR 417
            I RR +L  + G+R
Sbjct: 1706 ILRRPSLQRRAGSR 1719


>gi|145580582 uromodulin-like 1 isoform 2 precursor [Homo sapiens]
          Length = 1446

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 44/171 (25%), Positives = 66/171 (38%), Gaps = 22/171 (12%)

Query: 89  RGVLKELP--------DQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKT 140
           +GV +E+P        DQ     VN    +     + +EST + +  +     GS S+  
Sbjct: 628 KGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVN 687

Query: 141 PPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRK 200
           P    Q     A SS    + GS +  SPS  STS    + + T+    G +GTT   + 
Sbjct: 688 P---SQRSTSHANSSQGSPSQGSPSQESPSQGSTSQASPSHRNTI----GVIGTTSSPKA 740

Query: 201 TDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF 251
           T     ++H      T G   L   P + +  S     + P   E  TG F
Sbjct: 741 TG----STHSFPPGATDGPLAL---PGQLQGNSIMEPPSWPSPTEDPTGHF 784


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/189 (21%), Positives = 84/189 (44%), Gaps = 31/189 (16%)

Query: 382 YTDDEDEDEDEDGSGESALAS----KIRRRDTLAIKLGNRPSKKELEDKNI--LQRTSEE 435
           Y+  E+E+E+ D    S++ +       RRD L ++L N+   + L  + +   QR +EE
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382

Query: 436 ERQEIRQQIGTKLVRRLSQRPTTEEL-------------EQRNILKQKNEEEEQEAKMEL 482
            ++++  +   ++  +  QR   EE              EQR   +++   EE+  + E 
Sbjct: 383 HKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEH 442

Query: 483 KRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWAR---------LTPA 533
           ++   RK       AE   R++ +  +Y+    S  + R+  +P  +         ++P+
Sbjct: 443 EQEYKRKQLEEQRQAERLQRQLKQERDYLV---SLQHQRQEQRPVEKKPLYHYKEGMSPS 499

Query: 534 DKAAIRKEL 542
           +K A  KE+
Sbjct: 500 EKPAWAKEI 508


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.124    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,418,156
Number of Sequences: 37866
Number of extensions: 1260946
Number of successful extensions: 15389
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 230
Number of HSP's successfully gapped in prelim test: 860
Number of HSP's that attempted gapping in prelim test: 9973
Number of HSP's gapped (non-prelim): 4560
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.