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Search of human proteins with 15431328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
(404 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 814 0.0
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 759 0.0
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 597 e-171
gi|15431332 caspase 1 isoform delta [Homo sapiens] 476 e-134
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 361 e-100
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 337 9e-93
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 335 6e-92
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 333 2e-91
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 333 2e-91
gi|209870073 caspase 5 isoform c [Homo sapiens] 323 2e-88
gi|209870075 caspase 5 isoform d [Homo sapiens] 261 6e-70
gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 216 2e-56
gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 176 4e-44
gi|55925612 caspase recruitment domain family, member 17 [Homo s... 169 3e-42
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 152 7e-37
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 110 2e-24
gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens] 97 2e-20
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 89 9e-18
gi|14790115 caspase 3 preproprotein [Homo sapiens] 80 3e-15
gi|14790119 caspase 3 preproprotein [Homo sapiens] 80 3e-15
gi|6912286 caspase 14 precursor [Homo sapiens] 80 4e-15
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 77 3e-14
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 77 3e-14
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 76 5e-14
gi|15718698 caspase 7 isoform delta [Homo sapiens] 69 6e-12
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 69 6e-12
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 69 6e-12
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 65 1e-10
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 65 1e-10
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 65 1e-10
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 814 bits (2102), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
Query: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 180
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
Sbjct: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 180
Query: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
Sbjct: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
Query: 241 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 300
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
Sbjct: 241 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 300
Query: 301 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 360
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
Sbjct: 301 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 360
Query: 361 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 361 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 759 bits (1961), Expect = 0.0
Identities = 383/404 (94%), Positives = 383/404 (94%), Gaps = 21/404 (5%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
VIPKGAQACQICITYICEEDSYLAGTLGLSA APQAVQDN
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDN 99
Query: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 180
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
Sbjct: 100 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 159
Query: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
Sbjct: 160 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 219
Query: 241 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 300
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
Sbjct: 220 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 279
Query: 301 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 360
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
Sbjct: 280 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 339
Query: 361 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 340 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 597 bits (1539), Expect = e-171
Identities = 292/292 (100%), Positives = 292/292 (100%)
Query: 113 APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE 172
APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE
Sbjct: 20 APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE 79
Query: 173 FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL 232
FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL
Sbjct: 80 FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL 139
Query: 233 VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV 292
VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV
Sbjct: 140 VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV 199
Query: 293 VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR 352
VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR
Sbjct: 200 VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR 259
Query: 353 LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 260 LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
Score = 40.0 bits (92), Expect = 0.004
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 476 bits (1226), Expect = e-134
Identities = 244/292 (83%), Positives = 244/292 (83%), Gaps = 48/292 (16%)
Query: 113 APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE 172
APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE
Sbjct: 20 APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEE 79
Query: 173 FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL 232
FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL
Sbjct: 80 FDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFL 139
Query: 233 VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGV 292
VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD
Sbjct: 140 VFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD---- 195
Query: 293 VWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGR 352
NVSWRHPTMGSVFIGR
Sbjct: 196 --------------------------------------------NVSWRHPTMGSVFIGR 211
Query: 353 LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 212 LIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263
Score = 40.0 bits (92), Expect = 0.004
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 361 bits (927), Expect = e-100
Identities = 198/405 (48%), Positives = 259/405 (63%), Gaps = 29/405 (7%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MA+ ++K + S+G+ + G+LD L++ VLN +E EK K +A DK R + DS
Sbjct: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
+ K A Q+ + + DQ S P +A +
Sbjct: 61 MQEKQRMAGQMLLQTF------------FNIDQIS----------------PNKKAHPNM 92
Query: 121 PAMPTSSG-SEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRR 179
A P SG S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R
Sbjct: 93 EAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPR 152
Query: 180 TGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGI 239
GA+ DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI
Sbjct: 153 NGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGI 212
Query: 240 REGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSV 299
EGICG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 213 LEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSP 272
Query: 300 GVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+
Sbjct: 273 ASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQK 332
Query: 360 YACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
Y+ C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 333 YSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 377
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 337 bits (865), Expect = 9e-93
Identities = 166/281 (59%), Positives = 208/281 (74%)
Query: 124 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 183
P S S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 41 PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
Query: 184 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 243
DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
Query: 244 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 303
CG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
Query: 304 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 363
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+
Sbjct: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
Query: 364 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 335 bits (858), Expect = 6e-92
Identities = 192/404 (47%), Positives = 245/404 (60%), Gaps = 28/404 (6%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MA+ K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS
Sbjct: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
+ K A Q+ + LNM Q + S P Q ++
Sbjct: 61 -LRKNRVAHQMFTQTL----------------------LNMD--QKITSVKPLLQ-IEAG 94
Query: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 180
P P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R
Sbjct: 95 P--PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARN 152
Query: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
GA DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI
Sbjct: 153 GAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGIL 212
Query: 241 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 300
EGICG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 213 EGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPA 272
Query: 301 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 360
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y
Sbjct: 273 SLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKY 332
Query: 361 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
+C C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 333 SCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 333 bits (854), Expect = 2e-91
Identities = 190/398 (47%), Positives = 242/398 (60%), Gaps = 28/398 (7%)
Query: 7 KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66
K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS + K
Sbjct: 78 KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 136
Query: 67 QACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTS 126
A Q+ + LNM Q + S P Q ++ P P S
Sbjct: 137 VAHQMFTQTL----------------------LNMD--QKITSVKPLLQ-IEAGP--PES 169
Query: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDI 186
+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA DI
Sbjct: 170 AESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDI 229
Query: 187 TGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGK 246
GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG
Sbjct: 230 VGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGT 289
Query: 247 KHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLS 306
H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS +S
Sbjct: 290 AHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALIS 349
Query: 307 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 366
++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C +
Sbjct: 350 SQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHL 409
Query: 367 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 410 MEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 333 bits (854), Expect = 2e-91
Identities = 190/398 (47%), Positives = 242/398 (60%), Gaps = 28/398 (7%)
Query: 7 KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66
K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS + K
Sbjct: 65 KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 123
Query: 67 QACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTS 126
A Q+ + LNM Q + S P Q ++ P P S
Sbjct: 124 VAHQMFTQTL----------------------LNMD--QKITSVKPLLQ-IEAGP--PES 156
Query: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDI 186
+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA DI
Sbjct: 157 AESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDI 216
Query: 187 TGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGK 246
GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG
Sbjct: 217 VGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGT 276
Query: 247 KHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLS 306
H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS +S
Sbjct: 277 AHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALIS 336
Query: 307 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 366
++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C +
Sbjct: 337 SQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHL 396
Query: 367 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 397 MEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 124 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 183
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 12 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 71
Query: 184 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 243
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 72 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 131
Query: 244 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 303
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 132 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 191
Query: 304 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 363
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 192 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 251
Query: 364 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 252 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 261 bits (668), Expect = 6e-70
Identities = 130/216 (60%), Positives = 156/216 (72%)
Query: 189 MTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKH 248
M LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60
Query: 249 SEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLP 308
++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS +S
Sbjct: 61 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120
Query: 309 TTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEE 368
++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C + E
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180
Query: 369 IFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
IFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216
>gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 1 [Homo sapiens]
Length = 197
Score = 216 bits (551), Expect = 2e-56
Identities = 116/148 (78%), Positives = 119/148 (80%), Gaps = 21/148 (14%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFI SMGEGTINGLLDELLQTRVLN+EEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
VIPKGAQACQICITYICEEDSYLA TLGLSA A QAVQDN
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAETLGLSA---------------------ALQAVQDN 99
Query: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQK 148
PAMPT S EG +KLC LE+AQRIWKQK
Sbjct: 100 PAMPTCSSPEGRIKLCFLEDAQRIWKQK 127
>gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 2 [Homo sapiens]
Length = 97
Score = 176 bits (445), Expect = 4e-44
Identities = 90/97 (92%), Positives = 91/97 (93%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFI SMGEGTINGLLDELLQTRVLN+EEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGN 97
VIPKGAQACQICITYICEEDSYLA TLGLSA GN
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN 97
>gi|55925612 caspase recruitment domain family, member 17 [Homo
sapiens]
Length = 110
Score = 169 bits (429), Expect = 3e-42
Identities = 89/110 (80%), Positives = 97/110 (88%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRK FIRS+GEGTINGLL ELL+TRVL++EE+E VK ENATVMDK RAL+DS
Sbjct: 1 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSS 110
VI KGA ACQICITYICEEDS+LAGTLGLSA TSGN+L QDSQ VL S
Sbjct: 61 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS 110
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 152 bits (383), Expect = 7e-37
Identities = 72/81 (88%), Positives = 73/81 (90%)
Query: 324 EKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 383
EK + S DNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR
Sbjct: 8 EKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 67
Query: 384 AQMPTTERVTLTRCFYLFPGH 404
AQMPTTERVTLTRCFYLFPGH
Sbjct: 68 AQMPTTERVTLTRCFYLFPGH 88
Score = 41.2 bits (95), Expect = 0.002
Identities = 19/23 (82%), Positives = 21/23 (91%)
Query: 1 MADKVLKEKRKLFIRSMGEGTIN 23
MADKVLKEKRKLFIRSMGE ++
Sbjct: 1 MADKVLKEKRKLFIRSMGEDNVS 23
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 110 bits (275), Expect = 2e-24
Identities = 84/263 (31%), Positives = 120/263 (45%), Gaps = 27/263 (10%)
Query: 160 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 215
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
Query: 216 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 275
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
Query: 276 KPKVIIIQACRGDSP--GVVWFKDSVGVSGNLSLPTTEEFEDDAIK----KAHIEKDFIA 329
KPK+ IQACRGD GV D + P EE + K + D I
Sbjct: 311 KPKMFFIQACRGDETDRGV----DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMIC 366
Query: 330 FCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTT 389
+ + R+ GS +I L + E AC V ++ KV + +G A
Sbjct: 367 GYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEF 426
Query: 390 ERV--------TLTRCFYLFPGH 404
R TL R YLFPGH
Sbjct: 427 HRCKEMSEYCSTLCRHLYLFPGH 449
>gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens]
Length = 90
Score = 97.4 bits (241), Expect = 2e-20
Identities = 48/89 (53%), Positives = 66/89 (74%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MAD++L++KR++FI S+G GTIN LLD LL+ V+++E+M KV+ EN TVMDK R LID
Sbjct: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGL 89
V KG ++C I ++CEED LA +GL
Sbjct: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 88.6 bits (218), Expect = 9e-18
Identities = 100/406 (24%), Positives = 169/406 (41%), Gaps = 42/406 (10%)
Query: 10 RKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENA-TVMDKTRALIDSVIPKGAQA 68
R+ +R + E ++ L D LL + +E ++R + + D+ R LI + +G+QA
Sbjct: 10 RRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQA 69
Query: 69 CQICITYICEEDS---YLAGTLGLSADQTSGNYLNMQDSQGVL--SSFPAPQAVQDNPAM 123
+ I+ C ED+ LA L + + +++ V+ P+ ++
Sbjct: 70 LPLFIS--CLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPR 127
Query: 124 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEF---DSIPRRT 180
P GS G + +LE + +A++ I+ LII N F + RT
Sbjct: 128 PVDIGSGGFGDVGALESLRG-----NADLAYILSMEPCGH-CLIINNVNFCRESGLRTRT 181
Query: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
G+ +D + +L + V+VK +LTA M L A + +H D +V +SHG
Sbjct: 182 GSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ-DHGALDCCVVVILSHG-- 238
Query: 241 EGICGKKHSEQVPDI-------LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPG-- 291
C H + + + + I N+ N +CPSL KPK+ IQAC G+
Sbjct: 239 ---CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHG 295
Query: 292 --VVWFKDSVGVSGNLSLPTTEEFED--------DAIKKAHIEKDFIAFCSSTPDNVSWR 341
V G+ P F++ DAI D S+ P VSWR
Sbjct: 296 FEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWR 355
Query: 342 HPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 387
P GS ++ L + +++A S D++ + +V + QMP
Sbjct: 356 DPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 80.1 bits (196), Expect = 3e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 164 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 220
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
Query: 221 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 280
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 281 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 339
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
Query: 340 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 378
WR+ GS FI L +++YA + I RKV FE
Sbjct: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 80.1 bits (196), Expect = 3e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 164 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 220
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
Query: 221 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 280
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 281 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 339
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
Query: 340 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 378
WR+ GS FI L +++YA + I RKV FE
Sbjct: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 79.7 bits (195), Expect = 4e-15
Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 160 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 219
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
Query: 220 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 277
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
Query: 278 KVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTP 335
KV IIQACRG+ PG D + + S T + D H+ S+
Sbjct: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTD----ALHV-------YSTVE 173
Query: 336 DNVSWRHPTMGSVFIGRLIE-------HMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPT 388
+++RH GS FI L++ H+ E + E+ R++ + +G+A+
Sbjct: 174 GYIAYRHDQKGSCFIQTLVDVFTKRKGHILEL-----LTEVTRRMAEAELVQEGKARKTN 228
Query: 389 TE-RVTLTRCFYL 400
E + TL + YL
Sbjct: 229 PEIQSTLRKRLYL 241
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 148 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267
+M L+ P H D ++HG R G +P + I +
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
Query: 268 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 327
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
Query: 328 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
+ ++ P VS+RH GS +I L H+++
Sbjct: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 148 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267
+M L+ P H D ++HG R G +P + I +
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
Query: 268 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 327
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
Query: 328 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
+ ++ P VS+RH GS +I L H+++
Sbjct: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 76.3 bits (186), Expect = 5e-14
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 164 LALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPE 223
L +I+ N F S+ R G D ++ + Q LG++V + N+T +M L+ P
Sbjct: 242 LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA 301
Query: 224 HKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 283
H D ++HG R G +P + I + CP L +KPK+ IQ
Sbjct: 302 HADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTALQCPRLAEKPKLFFIQ 356
Query: 284 ACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHP 343
AC+G+ + SV + + P E+ E DF+ ++ P VS+RH
Sbjct: 357 ACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
Query: 344 TMGSVFIGRLIEHMQE 359
GS +I L H+++
Sbjct: 410 EEGSWYIQSLCNHLKK 425
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 69.3 bits (168), Expect = 6e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 166 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 222
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 104 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 162
Query: 223 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 282
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 163 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 216
Query: 283 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 342
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 217 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 267
Query: 343 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 373
P GS F+ L ++E+ ++ +I +V
Sbjct: 268 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 298
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 69.3 bits (168), Expect = 6e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 166 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 222
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 223 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 282
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
Query: 283 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 342
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
Query: 343 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 373
P GS F+ L ++E+ ++ +I +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 69.3 bits (168), Expect = 6e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 166 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 222
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 223 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 282
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
Query: 283 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 342
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
Query: 343 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 373
P GS F+ L ++E+ ++ +I +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)
Query: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 175
S E + ++ ++ R +S + + S+ R LII N F S
Sbjct: 256 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 315
Query: 176 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 235
I R G +D +T + L + + + T + L+ + +H D +
Sbjct: 316 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 374
Query: 236 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 290
SHG + GI ++ P I +L + F L CPSL KPKV IQAC+GD+ P
Sbjct: 375 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 429
Query: 291 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 350
++ + +LS P T D+A DF+ ++ + VS+R+P G+ +I
Sbjct: 430 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 481
Query: 351 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 386
L + ++E D+ I +V + D + M
Sbjct: 482 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 518
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)
Query: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 175
S E + ++ ++ R +S + + S+ R LII N F S
Sbjct: 197 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 256
Query: 176 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 235
I R G +D +T + L + + + T + L+ + +H D +
Sbjct: 257 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 315
Query: 236 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 290
SHG + GI ++ P I +L + F L CPSL KPKV IQAC+GD+ P
Sbjct: 316 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 370
Query: 291 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 350
++ + +LS P T D+A DF+ ++ + VS+R+P G+ +I
Sbjct: 371 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 422
Query: 351 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 386
L + ++E D+ I +V + D + M
Sbjct: 423 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 459
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 158 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207
KS LII N F SI R G +D +T + L + + + T
Sbjct: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
Query: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
Query: 268 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 322
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
Query: 323 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 381
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
Query: 382 GRAQM 386
+ M
Sbjct: 440 DKKNM 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,224,698
Number of Sequences: 37866
Number of extensions: 651409
Number of successful extensions: 1925
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1844
Number of HSP's gapped (non-prelim): 73
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.