Guide to the Human Genome
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Search of human proteins with 154277120

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154277120 spectrin repeat containing, nuclear envelope 1
isoform 3 [Homo sapiens]
         (982 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154277120 spectrin repeat containing, nuclear envelope 1 isof...  1947   0.0  
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...  1947   0.0  
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...  1890   0.0  
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...  1890   0.0  
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...   965   0.0  
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof...   935   0.0  
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo...   363   e-100
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo...   309   9e-84
gi|221316624 dystonin isoform 4 [Homo sapiens]                        126   1e-28
gi|221316622 dystonin isoform 3 [Homo sapiens]                        126   1e-28
gi|221316618 dystonin isoform 2 [Homo sapiens]                        126   1e-28
gi|34577047 dystonin isoform 1 [Homo sapiens]                         126   1e-28
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             126   1e-28
gi|33188443 microfilament and actin filament cross-linker protei...   120   5e-27
gi|33188445 microfilament and actin filament cross-linker protei...   120   5e-27
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                   110   6e-24
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]                  110   6e-24
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]                110   6e-24
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]                  110   6e-24
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                  110   6e-24
gi|5032285 dystrophin Dp427l isoform [Homo sapiens]                   110   6e-24
gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                   110   6e-24
gi|110611228 utrophin [Homo sapiens]                                   93   1e-18
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...    90   1e-17
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    90   1e-17
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...    89   2e-17
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...    89   2e-17
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]           84   8e-16
gi|5032307 dystrophin Dp140c isoform [Homo sapiens]                    83   1e-15
gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]                   83   1e-15

>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform
           3 [Homo sapiens]
          Length = 982

 Score = 1947 bits (5044), Expect = 0.0
 Identities = 982/982 (100%), Positives = 982/982 (100%)

Query: 1   MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
           MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 1   MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60

Query: 61  TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
           TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 61  TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120

Query: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
           ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180

Query: 181 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
           ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 181 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240

Query: 241 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
           KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 241 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300

Query: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
           ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360

Query: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
           VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420

Query: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
           LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480

Query: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
           RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540

Query: 541 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
           IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 541 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600

Query: 601 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
           GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 601 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660

Query: 661 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
           QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 661 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720

Query: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
           SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780

Query: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
           MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840

Query: 841 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
           LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 841 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900

Query: 901 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
           HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 901 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960

Query: 961 LSNNFARSFHPMLRYTNGPPPL 982
           LSNNFARSFHPMLRYTNGPPPL
Sbjct: 961 LSNNFARSFHPMLRYTNGPPPL 982


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 1947 bits (5044), Expect = 0.0
 Identities = 982/982 (100%), Positives = 982/982 (100%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 7768 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7827

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 7828 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7887

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 7888 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 7947

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 7948 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8007

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 8008 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8067

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 8068 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8127

Query: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
            VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 8128 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 8187

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
            LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 8188 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8247

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
            RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 8248 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 8307

Query: 541  IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
            IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 8308 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8367

Query: 601  GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
            GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 8368 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8427

Query: 661  QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
            QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 8428 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8487

Query: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
            SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 8488 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8547

Query: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
            MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 8548 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8607

Query: 841  LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
            LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 8608 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8667

Query: 901  HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
            HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 8668 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8727

Query: 961  LSNNFARSFHPMLRYTNGPPPL 982
            LSNNFARSFHPMLRYTNGPPPL
Sbjct: 8728 LSNNFARSFHPMLRYTNGPPPL 8749



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 150/874 (17%), Positives = 347/874 (39%), Gaps = 79/874 (9%)

Query: 18   EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 77
            + +L  + +R++ + +     V K ++ +   Q+  +++ +   WL   + +L +  V +
Sbjct: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529

Query: 78   SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 137
              ++   +  L + QELQ    +    + SVL+  E ++      A D   +S++Q    
Sbjct: 3530 G-DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD--- 3585

Query: 138  LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 197
                W+       E R +        +     + + ++WLK++E                
Sbjct: 3586 ----WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE--------------- 3626

Query: 198  KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNLQ 255
            K+  ++  A++ +V E       +  + + +  E+  +S   C   Q+      R+  L 
Sbjct: 3627 KKWHEEVTAYRDEVEE-------VGARAQEILDESHVNSRMGCQATQLT----SRYQALL 3675

Query: 256  KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQL 311
             +V   ++ L+  I   EE E++  S   W         N    I+      +  K+K L
Sbjct: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735

Query: 312  KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 371
            +   +++   H+ ++    +GE+ ++  E  +A  + +E+ +     +E+   V + H  
Sbjct: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMT 3795

Query: 372  LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 431
            L +      E     + L    +     LH  +     L   +   +   SL Q + S  
Sbjct: 3796 LEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHE 3855

Query: 432  SGRDTPASVDSIPLEWDHDYDLSRDLESAMS---------RALPSEDEEGQDDKDFYLRG 482
                +        LE   D  L   ++   S         +A+  E+  G +D+   L  
Sbjct: 3856 PSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAM-MEEIAGFEDR---LNN 3911

Query: 483  AVGLSDVMIPESPE-AYVKLTENA---IKNTSGDHSALESQIRQLGKALDDSRFQIQQTE 538
                 D +I +  +    KL +N    ++ T   +SA+ S  +++ ++L+    +    +
Sbjct: 3912 LQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQ 3971

Query: 539  NIIRS----KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS 594
            + ++      +   P+L+ S +  +    E    +   + L+ + +   + L    +L +
Sbjct: 3972 DTLQQCQAWLSAVQPDLEPSPQPPLSR-AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4030

Query: 595  TETQT-AGVIDRWELLQAQALSKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               +T A  I + E    Q + ++L   QNL Q W++     + +W +L D +++L+ ++
Sbjct: 4031 ASVKTTAKDIQQTE----QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
            R     ++   +  + ++K+  K +  ++A   S+N    +  +   KE       ++ +
Sbjct: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHL 4143

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            N +W  +C          ++ L + + +H+  + + + LE      + +    +  DAE 
Sbjct: 4144 NDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAES 4199

Query: 773  LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----K 828
               H + L ++   L E +  +  L+D   +++ +    D    KE+   +  R      
Sbjct: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4259

Query: 829  LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 862
            L+ +++   +  LE+L  V S  Q+L  W+   +
Sbjct: 4260 LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 155/845 (18%), Positives = 337/845 (39%), Gaps = 72/845 (8%)

Query: 50   QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 109
            Q+ ++N+  ++  ++  E +LA PI   S ++ E  + L E  +L + +E  S+ + +  
Sbjct: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICS-SATETYKVLQEHMDLCQALESLSSAITAFS 1620

Query: 110  NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 169
                 +++  D+C  +A           L +++ +I   + ER+  +E     WQ+   +
Sbjct: 1621 ASARKVVNR-DSCVQEAAA---------LQQQYEDILRRAKERQTALENLLAHWQRLEKE 1670

Query: 170  YSRFEDWLKSSERTAAFPSSSGVIYTVAKE-ELKKFEAFQRQVHECLTQLELINKQYRRL 228
             S F  WL+  E  A+ P        V  E EL+  +A Q +V    +    + +    L
Sbjct: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730

Query: 229  ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTE 288
                  D    +K  + + ++RW +L + +   +  L+  + + ++F+    S  VW+  
Sbjct: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1790

Query: 289  MDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
               +L      S  D Q  + + K    E+     +++ +     +L       D  +++
Sbjct: 1791 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH--------------DLSDRELELEDS 394
             + ++  +  +E    VER    L  L      H              + ++   + E  
Sbjct: 1851 GKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESD 1910

Query: 395  AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ---PLRSERSGRDTPASVDSIPLEWDHDY 451
                DL+   ++A +L S   S +  LS AQ    + S        A+ D +  E +   
Sbjct: 1911 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1970

Query: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 511
            +L    +S  + AL    +  QD K+  L+    + D+      E   + T  A++    
Sbjct: 1971 NLLGTKQSE-ADALAVLKKAFQDQKEELLK---SIEDIEERTDKERLKEPTRQALQQRLR 2026

Query: 512  DHSALESQIRQLGKA---LDDSRFQIQQTENIIRSKTPTG-PELDTSYKGYMKLL----G 563
              + LE ++         L D   QI Q +     +       L+ ++    +L+    G
Sbjct: 2027 VFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQG 2086

Query: 564  ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID-RWELLQAQALSKELRMKQ 622
            +C   ID ++  ++      + L    ++  T T      D +W   + +    ++  KQ
Sbjct: 2087 QCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2146

Query: 623  NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKK-LKELQKAVDHRK 681
                      DL++  +       EL+++   + S     +E  + K L   +K  ++  
Sbjct: 2147 ---------KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2197

Query: 682  AIILSINLCSPEFTQADSKES------RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 735
             + +S+++     +  D  E         + + +S ++    R   LL+E+   +++  +
Sbjct: 2198 RLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-RAEELLKEFESEVKNKAL 2256

Query: 736  QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ--DHHKQLMQIKHELLESQLR 793
            + +  H   + L  + +N+     E  P    ++A+++Q  +H K++     E+ +  L+
Sbjct: 2257 RLEELHSKVNDLKELTKNL-----ETPPDLQFIEADLMQKLEHAKEIT----EVAKGTLK 2307

Query: 794  VASLQDMSCQLLVNAEGTDCLEAKEK-VHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQ 851
              + Q    +  +N   T   + +E  ++   N     LK+V    KEL+ +  ++SS+Q
Sbjct: 2308 DFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQ 2367

Query: 852  QDLSS 856
            ++L+S
Sbjct: 2368 ENLNS 2372



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G++L  ++     + ++ +L ++ ++W+     +  + KKL   L   ++ +K ++    
Sbjct: 7557 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 7616

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
             L   + +L++ +        +   +L+ +Q   +++E         L    +L     A
Sbjct: 7617 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7669

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
              +  +   + +    L R+W  +C     RR +I E    W  F +      +WL   E
Sbjct: 7670 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7729

Query: 182  RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241
               +   +  ++     E+LKK   +Q ++         + +   RLA+ +    A  ++
Sbjct: 7730 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 7785

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301
              + + N RW +L   + + +++LK  +   ++ +    S+  WL  ++ +L     +  
Sbjct: 7786 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7845

Query: 302  C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
            C   ++Q K+ + +  Q++I  +   +  ++   E L+      DA   + E D +++
Sbjct: 7846 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 7900



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)

Query: 4    RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60
            +L K  H      +   L +VN RW +LL+ IA +++  K  L   Q+     K  +S  
Sbjct: 7125 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 7184

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
                   +EL K         +E+   + +  +L + +      +  +  L E L    D
Sbjct: 7185 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 7244

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177
            A A  A    IQ    +L    +++CA+     +++  ++     ++ F       E W+
Sbjct: 7245 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7297

Query: 178  KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
              +E       PS S  + T+ +E +++ +    +       L+ +N+   RL   ++  
Sbjct: 7298 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 7354

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294
                +K+M    N+ W  +  + T    +L+ F+ Q + F    ++ + +L + + +L  
Sbjct: 7355 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7410

Query: 295  ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
                N +H  E   Q +  +L  FQ E+      +  II  G++L+E+ +  D      +
Sbjct: 7411 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7465

Query: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
            L  L    Q V  R ++      R  + D +     R  E+ +           R     
Sbjct: 7466 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 7510

Query: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
            +S  P S L  S+  PL+  R+  D     + + L     Y L+ +    +  +  S  E
Sbjct: 7511 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 7569

Query: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
                 +   ++     + + + E  +    L ++  K   G   +LE ++R   K L  S
Sbjct: 7570 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 7628

Query: 531  -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579
                       + + ++ EN + S T      D +    +K       S D +  L  ++
Sbjct: 7629 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 7683

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
            +  +                     +WE L  Q   +  ++ + L +W  F+     +  
Sbjct: 7684 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 7723

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698
            WL   E ++ Q      + DI   E+  K  K+ Q+ +   +   + +        +A  
Sbjct: 7724 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7777

Query: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
              ++ +++ +L ++N RW  +  L+      L++ L+  Q   +    L   L +I+   
Sbjct: 7778 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7837

Query: 759  NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807
             + +  DS  ++E +Q    +  +++ ++ +    VAS+ ++ C++L++
Sbjct: 7838 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 7884



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 148/839 (17%), Positives = 321/839 (38%), Gaps = 117/839 (13%)

Query: 29   QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKL 88
            +  L+  +A +K   + L  ++  + +   +  W  H   E+   +      +E+++ +L
Sbjct: 2973 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECW--HKGQEILDALQKAEPRTEDLKSQL 3030

Query: 89   NEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 148
            NE     RD+  +S  V+ ++       ++C        C + +Q               
Sbjct: 3031 NELCRFSRDLSTYSGKVSGLIKE-----YNCLCLQASKGCQNKEQI-------------- 3071

Query: 149  SMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQ 208
                         L Q+F   +  F+ WL +++ T A         +     L+K + F 
Sbjct: 3072 -------------LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFL 3118

Query: 209  RQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 268
             +      +L ++  +   L+     + A  ++  V    + W N    +      L++ 
Sbjct: 3119 SESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENL 3178

Query: 269  IGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKI 325
              Q ++FE + + I  WL++ + ++ +       D+ AK ++ +  Q   +EI     ++
Sbjct: 3179 KIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3237

Query: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
             ++  + +QL E      +      + +L      +    +    +L R+    ++  L 
Sbjct: 3238 NRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLG 3295

Query: 386  DRELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 443
             +EL+  + D+  + D + H  S  S+L  + +  L   L+     E   +      +S+
Sbjct: 3296 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV 3354

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
                         L++     +P+  ++ Q  KD +      L    I           +
Sbjct: 3355 -------------LQNTSPEGIPTIQQQLQSVKDMW----ASLLSAGIR---------CK 3388

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMK 560
            + ++      ++ +  +RQ    +D     + ++E     +R KT        +  G  K
Sbjct: 3389 SQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAK 3440

Query: 561  LLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRM 620
            LL E   S  S+      L+  E    G    + T+ +   + +R+  +Q +A     + 
Sbjct: 3441 LLNEEVLSYSSL------LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3494

Query: 621  KQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR 680
            ++ ++  Q++  DL +   WLG  +E+L+Q   LE   D  T E  ++ L+ELQ      
Sbjct: 3495 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEG 3552

Query: 681  KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 740
            +A++ S+     +   +   ++   +DR  +         SL ++W+            F
Sbjct: 3553 QALLNSVLHTREDVIPSGIPQA---EDRALE---------SLRQDWQAYQHRLSETRTQF 3600

Query: 741  HEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800
            + + + L LM +   +       +D  L     +  H+++   + E+ E   R   + D 
Sbjct: 3601 NNVVNKLRLMEQKFQQ-------VDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDE 3653

Query: 801  SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQDLSSWS 858
            S    VN+    C   +     + +R + LL +V   IK L E++  +  S+  LSS+S
Sbjct: 3654 S---HVNSR-MGCQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3703



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 129/808 (15%), Positives = 321/808 (39%), Gaps = 88/808 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            ++++    +  + +H  ++       LK+      Q++K ++ + TW   +E  L     
Sbjct: 2280 DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLM---- 2335

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
              +C   E    L + +++Q++++   + ++S       L     +    AE +S+ +A 
Sbjct: 2336 --NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESLGRAM 2389

Query: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
              L ++   +  +  + +  ++E+  L + F +    F++W   ++  A   S       
Sbjct: 2390 TGLIKKHEAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSK 2447

Query: 196  VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 255
            V + +L   +     V +  ++L+ + ++ + L          S+++ + + N+ +    
Sbjct: 2448 VLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFL 2507

Query: 256  KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-----DVQAKIKQ 310
            K+     + L+    +   FE     + +W+ EM+ +  N E+  E      + + ++ +
Sbjct: 2508 KQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME-ERFNTENLGESKQHIPEKKNEVHK 2566

Query: 311  LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
            ++ F  E+      ++++  +G+ L E+              +  R C ++       H+
Sbjct: 2567 VEMFLGELLAARESLDKLSQRGQLLSEEG---------HGAGQEGRLCSQLL----TSHQ 2613

Query: 371  KLIRLPLPDDEHDLSDRELELEDSAALSDL-----HWHDRSADSLLSPQPSSNLSLSLAQ 425
             L+R+     +  L   ++ L++  AL +       W     D L   + +     +L +
Sbjct: 2614 NLLRM----TKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669

Query: 426  PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVG 485
             L   +         D + ++ + +  L+  +     +AL S ++EGQ      L     
Sbjct: 2670 RLSQIQ---------DILLMKGEGEVKLNMAIGKG-EQALRSSNKEGQRVIQTQLETLKE 2719

Query: 486  L-SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544
            + +D+M   S   + + T  ++ +   D+   ++Q+ Q  +++D      Q+ E+ ++ +
Sbjct: 2720 VWADIM---SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD------QKIEHPLQPQ 2770

Query: 545  TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGV 602
             P   E          +L E      ++ RL  K +E  E+     F +    E +T   
Sbjct: 2771 -PGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKT--- 2826

Query: 603  IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
              ++  +   A  K  ++++ ++    +   ++    WL   +EEL +    ++S D   
Sbjct: 2827 --QFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS--DMSGDSSA 2882

Query: 663  IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMNGRWDRVCS 721
             + ++ K+KEL  + +   + +  +   +PE  Q  +    +L    +  +   W +   
Sbjct: 2883 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2942

Query: 722  LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---------DSNLDAEI 772
             + + +  L++ + Q     +   G +  LE    + + ++             N D EI
Sbjct: 2943 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 3002

Query: 773  LQDHHK--------QLMQIKHELLESQL 792
            ++  HK        Q  + + E L+SQL
Sbjct: 3003 VECWHKGQEILDALQKAEPRTEDLKSQL 3030



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)

Query: 15   SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71
            S++E +L ++ + W    + ++  + +L+  L    +     + L  WL   +  L    
Sbjct: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +  V      E ++  LN   E  ++++  S+  +SVL+    LL          +  ++
Sbjct: 6752 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 6806

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190
            +     +D +W ++       + K+ +            S    W+   E        + 
Sbjct: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866

Query: 191  --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241
               + Y    E L+K++ F+  ++     ++ +N+   +++       R ++TD A  L 
Sbjct: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300
             M    N+ W  LQ  VT  ++ L+  +    E+E     +  W    + +L        
Sbjct: 6927 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 6982

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            +  VQ  +K  +  +  I     ++E+I   G  LI+  +   ++I+   L EL +    
Sbjct: 6983 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 7042

Query: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
            +                   +H +   ++ L+  + L     H  + D + S    +  S
Sbjct: 7043 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 7081

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
            LS  + L           S++++ ++ D+  +L  DLE                 ++  L
Sbjct: 7082 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 7116

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529
            +    +++ ++ E      +   N +K  +   + L  +I    Q  KAL        D 
Sbjct: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 7176

Query: 530  SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
            S+     +QQ E+      K  T  ++ D     +++   +    + +VK     L E  
Sbjct: 7177 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 7236

Query: 584  ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640
            E L   V+  +     +  +   + L A  QAL K +  ++  +  ++ F   L ++ AW
Sbjct: 7237 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 7296

Query: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
            + + EE L Q Q    S+D+ TI+ ++++L          K  +L  +  +P+  + +  
Sbjct: 7297 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 7345

Query: 701  ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
              R  L D    R+  +N  W  + S   E    LQ  L+Q Q F          LE  +
Sbjct: 7346 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 7395

Query: 756  RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792
                 +V  +  L  EI  ++   L Q + HEL ++++
Sbjct: 7396 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 7433



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+RL +        E   KL  ++++WQ ++     R   +   +   Q+  +    LR 
Sbjct: 7447 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 7506

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            WL  +       +       ++ +   +E Q  ++   +        +   + LL   D+
Sbjct: 7507 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 7566

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
             A  A    +Q     +  +W++      E++ K+    + W+K     +   + L++ +
Sbjct: 7567 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7622

Query: 182  R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +  + + P     ++   +   K+ E       + LTQL L+      L+     D    
Sbjct: 7623 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 7678

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
            L + V    ++W+ L  +++   +++   + +   F      +  WLT+M+   + +   
Sbjct: 7679 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 7735

Query: 300  SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
             +  ++  I++LK  +Q+EI++      Q+   GE+L + S    A+ IE +L ++    
Sbjct: 7736 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
            Q +   +    KKL                   E   A+  L   D++  SL +    ++
Sbjct: 7796 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 7832

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476
            +   LA+P+  +        + + I  + +   +L RD+E  S    ++ +  E    D 
Sbjct: 7833 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 7886

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533
            D     A   S   I ++     +   N    +      +E   R   K LDD SRF+  
Sbjct: 7887 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 7943

Query: 534  IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587
            ++ +E      + +G       E    ++ + + + EC + ++ + +   +L  E  +  
Sbjct: 7944 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 8001

Query: 588  GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647
               +  S +        RW+ LQ +  S   R+K  + + ++F +  +SI  WL + + +
Sbjct: 8002 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 8059

Query: 648  LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681
            L  ++      D+Q    +IK+LK  Q+  +++H K
Sbjct: 8060 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 8091



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 163/931 (17%), Positives = 353/931 (37%), Gaps = 144/931 (15%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            ++E K+  +  R Q +     A+V  L+          K    +   +   E +L++  +
Sbjct: 4999 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
              + +S E + KL+E + L   +      + ++    E      +    DA   ++ ++ 
Sbjct: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL----EEKASQLEKTGNDASKATLSRSM 5114

Query: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
              + +RW  + A++ ++   +E+    W  F +   +  + +   +      S+      
Sbjct: 5115 TTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKA 5174

Query: 196  VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS---LKQMVHEGNQRWD 252
                 L+  + F  ++ +  + L ++ +Q   + ++    +      L Q +     R  
Sbjct: 5175 ELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5234

Query: 253  NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK 312
            N+Q++V +  + +K  +  RE  ET  +S+  W+ E    L N       ++ A++++L+
Sbjct: 5235 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN----PTIEIDAQLEELQ 5290

Query: 313  AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
                E + +   IE++                                     E   +K 
Sbjct: 5291 ILLTEATNHRQNIEKM------------------------------------AEEQKEKY 5314

Query: 373  IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 432
            + L      + +   EL L+ +    DL   D+  D +   + S   S  L++ ++    
Sbjct: 5315 LGL------YTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQK--- 5365

Query: 433  GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIP 492
                                L++DL + +++     D   Q   D           V+  
Sbjct: 5366 --------------------LAKDLTTILTKLKAKTDNVVQAKTD---------QKVLGE 5396

Query: 493  ESPEAYVKLTE--NAIKNTSGDHSALESQI-RQLGKALDDSRFQIQQTENIIRSKTPTGP 549
            E      KL E   A++     +  L   + +++GK  +  +  I+Q EN +        
Sbjct: 5397 ELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAAS 5456

Query: 550  ELDTSYKGYMKLLGECSSSIDSVKRLEHK--LKEEEESLPGFVNLHSTETQTAGVIDRWE 607
             L+     Y ++L      I+  K L H          L     LH T  + +  ID   
Sbjct: 5457 HLEE----YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS-- 5510

Query: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
              + +A++++L+   ++   ++ +  +    A LG   EEL Q+ ++ L  ++Q     +
Sbjct: 5511 --ELEAMTEKLQYLTSVYCTEKMSQQV----AELGRETEELRQMIKIRLQ-NLQDAAKDM 5563

Query: 668  KK----LKELQKAVDHRKAIILSINLCSPEFTQADSKES-RDLQDRLSQMNGRWDRV--C 720
            KK    LK+LQ A++  +A      L SPE  +   KE     Q  LS+M     +V   
Sbjct: 5564 KKFEAELKKLQAALEQAQA-----TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 5618

Query: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ------ 774
             L +    + +D +        + H  L + E   R ++  +   + + A ++Q      
Sbjct: 5619 QLCQSALRIPEDVVASL----PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5674

Query: 775  --DHHKQLMQIKH-ELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLL 830
               H +QL++  H E+ +  +  +++Q++  Q+  + E    ++  +E++  + ++ K+L
Sbjct: 5675 EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKML 5734

Query: 831  LKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSL 890
              + ++H   L  + +V    +           D  G + PT   + P+      G+C  
Sbjct: 5735 TMK-AKHATMLLTVTEVEGLAEGTE--------DLDGELLPTPS-AHPSVVMMTAGRCH- 5783

Query: 891  SQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS 921
                  +S     S + G++S +S P   RS
Sbjct: 5784 ----TLLSPVTEESGEEGTNSEISSPPACRS 5810



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 181/887 (20%), Positives = 351/887 (39%), Gaps = 150/887 (16%)

Query: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
            L + S E++A +   +L K++  ++ L+ L++   K L      VQ  +   +SL   ++
Sbjct: 1198 LTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELIS 1257

Query: 65   ---HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
                ++ +  K  + D+ N  E Q+ L   Q+  + I      V   +   +      + 
Sbjct: 1258 GSKEVQEQAEK--ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQ----QGEG 1311

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL---- 177
               D   + +++    LD   R+      ERR+++  T R W++F  +      +L    
Sbjct: 1312 GLPDRGHEELRKLESTLDGLERS--RERQERRIQV--TLRKWERFETNKETVVRYLFQTG 1367

Query: 178  KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR--LARENRT- 234
             S ER  +F S   +       EL++ + F ++      Q E + K+     L  +N+  
Sbjct: 1368 SSHERFLSFSSLESL-----SSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL 1422

Query: 235  --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
                A S+K+ V +     +   K +  +  +  HF      FET    + VW+TE + +
Sbjct: 1423 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHF---GSNFET----LSVWITEKEKE 1475

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352
            L  +E  S   +  +I Q+K   QEI    + I  +  + +   +     ++A I+ +L 
Sbjct: 1476 LNALETSSSA-MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1534

Query: 353  ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412
            ++RRY +E+     R H + +                   +   L  L    +  ++L  
Sbjct: 1535 QIRRYGEEL-----REHAQCL-------------------EGTILGHLSQQQKFEENLRK 1570

Query: 413  PQPS-SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
             Q S S     LA P++   S  +T   +           DL + LES +S A+ +    
Sbjct: 1571 IQQSVSEFEDKLAVPIKICSSATETYKVL-------QEHMDLCQALES-LSSAITAFSAS 1622

Query: 472  GQD--DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI---RQLGKA 526
             +   ++D  ++ A  L             +  E+ ++      +ALE+ +   ++L K 
Sbjct: 1623 ARKVVNRDSCVQEAAALQ------------QQYEDILRRAKERQTALENLLAHWQRLEKE 1670

Query: 527  LDDSRFQIQQTENIIRSKTPTGPELDTS-----YKGYMKLLGECSSSIDSVKRLEHKLKE 581
            L      +++ E        + PE+D S      +G ++L+    + + S      KL +
Sbjct: 1671 LSSFLTWLERGE-----AKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQ 1725

Query: 582  EEESLPGFV---NLHSTETQTAGVIDRWELLQAQALSKELRMKQN-LQKWQQFNSDLNSI 637
             +ESL       ++   +     + +RW  L  Q ++K +   Q+ + + QQF+  L S 
Sbjct: 1726 LKESLFSVASKDDVKMMKLHLEQLDERWRDL-PQIINKRINFLQSVVAEHQQFDELLLSF 1784

Query: 638  WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 697
              W+         L  L+ +++I  ++ Q+     L +  DH   +            ++
Sbjct: 1785 SVWI------KLFLSELQTTSEISIMDHQV----ALTRHKDHAAEV------------ES 1822

Query: 698  DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC-QGFHEMSHGLLLMLENIDR 756
               E + LQ  L+++ G   R   L      LLQ     C Q F E S       + ++R
Sbjct: 1823 KKGELQSLQGHLAKL-GSLGRAEDL-----HLLQGKAEDCFQLFEEAS-------QVVER 1869

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
            R+  +  +     AE LQ  H  L  I  +L ++     S+       L+  +  D L+ 
Sbjct: 1870 RQLALSHL-----AEFLQS-HASLSGILRQLRQTVEATNSMNKNESD-LIEKDLNDALQN 1922

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
             + +      L  +L +   H+K       + SS+Q  S  ++AD+L
Sbjct: 1923 AKALESAAVSLDGILSKAQYHLK-------IGSSEQRTSCRATADQL 1962



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 142/799 (17%), Positives = 312/799 (39%), Gaps = 95/799 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            +L K+ D +  L+ +I +R   L + L    Q ++ +  L   L   + ++A        
Sbjct: 6488 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 6547

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            + EEIQ+ L++ +E  + +E H       + L E L     + A   E     Q    L 
Sbjct: 6548 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 6596

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             +   +   + +R +++E     W   LD     ED  + S +     SS   +  V + 
Sbjct: 6597 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 6650

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256
            E +  +      H   +  E   K Y+ L    R   + S   L+  +++  + W +   
Sbjct: 6651 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6710

Query: 257  RVTSILRR----LKHFIGQREE-------FETARDSILVWLTEMDLQLTNIEHFSECDVQ 305
            +++  L R    LKH+   + E        ++A+D +  W  +       +E      V+
Sbjct: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEM-----VR 6765

Query: 306  AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 365
              +     F +E+    +    +++ G QL+ + + +D A +  EL  +     ++   +
Sbjct: 6766 DHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNI 6824

Query: 366  ERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQ 425
                +KL +L +            +L    A+S++       ++++  +   N+  S+  
Sbjct: 6825 PAVQEKLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGY 6872

Query: 426  PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-G 482
                E   +     +D       +   L+ D  +     + S+D E +  D  DF  + G
Sbjct: 6873 KAIHEYLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926

Query: 483  AVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
            A+  S  ++       ++L E  +++     S  E+ ++ L    +    +++Q   I  
Sbjct: 6927 AMNKSWQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI-- 6980

Query: 543  SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 602
                               L +C    D +K  E ++++ E++  G   + + +   + +
Sbjct: 6981 ----------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSI 7028

Query: 603  I--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL 654
            +          W  L       ++ +K  L +W       + I ++L +    L + +  
Sbjct: 7029 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL- 7087

Query: 655  ELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMN 713
             L+  ++ +++Q+  L+ LQ  ++ ++  +    ++ +    +     +  L + L ++N
Sbjct: 7088 -LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVN 7146

Query: 714  GRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA 770
             RW+   +LLEE    LQ   AL+Q  Q + + S      ++  + R NE++   +N D 
Sbjct: 7147 MRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD- 7202

Query: 771  EILQDHHKQLMQIKHELLE 789
             I  D     +Q  ++LL+
Sbjct: 7203 -IADDEVATWIQDCNDLLK 7220



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 114/604 (18%), Positives = 241/604 (39%), Gaps = 106/604 (17%)

Query: 303  DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
            DV  ++K  K+ Q  +    N++  + AQG +L+++    + + +  +L EL+     V 
Sbjct: 4417 DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL 4476

Query: 363  G----RVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL---------SDLHWHDRSADS 409
                 R++   K L+      ++ D +   L+  D             S+LH       +
Sbjct: 4477 QKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQN 4536

Query: 410  LLSPQPS-SNLSLSLAQ------PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMS 462
            +L   P   NL L+L +      P  +E         ++++P +++    L++D    + 
Sbjct: 4537 ILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQ 4596

Query: 463  RALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT--------ENAIKNTSGDHS 514
             A+ +  E             + L+   + E    +++++        E A+    G  +
Sbjct: 4597 EAILARKEYAS---------LIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRA 4647

Query: 515  ALESQIRQLGKALDD---------SRFQIQQTENII-------RSKTPTGPELD------ 552
             L+ ++  LG+A+D+         S  Q  Q + ++       R K  T   +       
Sbjct: 4648 ILD-EVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTT 4706

Query: 553  TSYKGYMKLLGECSSSIDSVKRLEHKLKEE----EESLPGFVNLHSTETQTAGVIDRWEL 608
            ++Y+ + K+  +    + SVK  + K+ EE    EE L  + +L  +  Q +G++ +   
Sbjct: 4707 SAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGS-LQDSGIVLKRVT 4765

Query: 609  LQAQALSKEL------RMKQNLQKWQ-------------------------QFNSDLNSI 637
            +  + L+  L      + +  +Q WQ                          F ++++  
Sbjct: 4766 IHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRS 4825

Query: 638  WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE-FTQ 696
              WL   + EL     L+L+  +Q I+ +I+K++  Q+ V     I+ +++    E FT+
Sbjct: 4826 LDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK 4883

Query: 697  ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
            A    S DL+  L++++     +   L   +  L +   QCQ ++++       LE+   
Sbjct: 4884 AKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--- 4940

Query: 757  RKNEIVPIDSN-LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL--LVNAEGTDC 813
               E++ +  N LD E  +++ K  M+      +    +  L  +   L  L+   G + 
Sbjct: 4941 -AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED 4999

Query: 814  LEAK 817
            LE K
Sbjct: 5000 LEQK 5003



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)

Query: 527  LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
            LD+ + ++ +   ++ S  P+     E +      + L     SS++  +   +++ ++ 
Sbjct: 6623 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 6682

Query: 584  ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642
            + L   ++    E+Q   + + W L     +SKEL R++  L+ W ++ S+   +  WL 
Sbjct: 6683 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6741

Query: 643  DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
              ++ LE    Q + +  +++ +   +    E  K VD + ++  S+     +  +    
Sbjct: 6742 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6801

Query: 701  ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
            ++  L+  LS+++ +W      + ++ E+   L  D L       E+   + LM EN+ +
Sbjct: 6802 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 6860

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813
            +  +   I +++  + + ++ ++    K ++   QL V  +     Q+    V ++ +D 
Sbjct: 6861 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6918

Query: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862
             +  E++  +    ++L   V+  I+ LE LL    +  ++ Q L +W    E
Sbjct: 6919 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 6971



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
            S  S  ++   +LG +N  WQ L  L+  +++ L+  L +  + + N+  L+TW    E 
Sbjct: 6913 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 6972

Query: 69   ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120
             L +   +   +   +Q  L + Q+L       ++++EK    G+A + N  E       
Sbjct: 6973 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 7023

Query: 121  ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
                  +  SI  +T R L + W N+  M  + ++ ++     W      + +   +L  
Sbjct: 7024 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077

Query: 180  SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
            +  + + F   +G +  V + ++   +  Q  + +    L+       +L +E       
Sbjct: 7078 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7136

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLK 266
            +L   + E N RW+NL + +   L+  K
Sbjct: 7137 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 7164



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76
            KLG +   W+ L ++I+ + + L E L   Q+   ++ S+ T +  IE   SE  +P   
Sbjct: 5865 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 5924

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                  E Q  ++E   LQ +I +  + +A      E++   C+  A  AE  ++Q    
Sbjct: 5925 PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 5977

Query: 137  NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183
             L  R   I   +  +R  +EE            +  Q++  +    + WL S++    T
Sbjct: 5978 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6037

Query: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
            A  P    +       + +       Q    L++L + N+      + +  D A  L   
Sbjct: 6038 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6097

Query: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298
            +         LQ+ +      ++    ++EE +     T    +  WL +     T    
Sbjct: 6098 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 6154

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350
                  Q+ ++Q K  +QE++   + +  + ++GE+++ +    + +        ++ +E
Sbjct: 6155 ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 6210

Query: 351  L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398
            L          D++R   + +        K L  +   + E  L  R   L     L   
Sbjct: 6211 LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 6270

Query: 399  DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451
            D+   D+SA  SLL        + SS    +  Q +  E+   D  ++  +    W  D 
Sbjct: 6271 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 6326

Query: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501
            +    + +A+   LP E E    +++   +    +S+ M           PE+ +    +
Sbjct: 6327 EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 6382

Query: 502  TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
             E+ +    G  S L+S + Q    + +   QI   +N +  K       D  Y    KL
Sbjct: 6383 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 6440

Query: 562  LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607
                    +  I+++++ E  LKE +    G + L            +  + + + D ++
Sbjct: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6497

Query: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
             L     S+   + QNL    Q+   L  +   L   +E++   Q++ +S+  +  +L  
Sbjct: 6498 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 6557

Query: 668  KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721
            K  +  Q    H   +IL+  L     + A  KE++   + ++Q +    R         
Sbjct: 6558 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6614

Query: 722  -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
             +LE W  L +D         E+S      LE ++     +  ++ N D   L D     
Sbjct: 6615 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 6661

Query: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
              +K  L E Q ++  + D   +LL++     C + + +++ +G        ++S+ +  
Sbjct: 6662 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 6718

Query: 841  LEKLLD----VSSSQQDLSSW--SSADELD 864
            LE +L       S   DL  W  S+ D L+
Sbjct: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLE 6748



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 161/928 (17%), Positives = 345/928 (37%), Gaps = 101/928 (10%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L+    + KA  I+ K+    + W++    +  +   L+   + ++  + +   ++ 
Sbjct: 3135 GELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQD 3194

Query: 62   WLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            WL+  E      +V++S N   ++  K  EQQ+LQ  +E+       +  L E      +
Sbjct: 3195 WLSKTEK-----MVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3249

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
                 A   S +     L  ++  +  ++ E+  +++       +F       +DW+  +
Sbjct: 3250 G---QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3306

Query: 181  ER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
                 +   P+S     +V      K EA      E   Q+++I  +   + +    +  
Sbjct: 3307 IHMLDSYCHPTSD---KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363

Query: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
             +++Q +      W +L         +L+  + +   ++        W+  M+  L   E
Sbjct: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423

Query: 298  --HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
              H    D    + + K   +E+    + +E I  +G  +   +E     +  ++L E  
Sbjct: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM---TEHYVTQLELQDLQERY 3480

Query: 356  RYCQEVFGRVERYHKKLIRL------PLPDDEHDLSDRELELEDSAAL-SDLHWHDRSAD 408
            R  QE         +KL+RL       L   E  L   + +L+  + L  D H H+ +  
Sbjct: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540

Query: 409  SLLSPQPSSNLSLSLAQPLRSERSG-------RDTPASVDSIPLEW---DHDYDLSRDLE 458
             L   Q       +L   +   R         +    +++S+  +W    H    +R   
Sbjct: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGA---------VGLSDVMIPESPEAYVKLTENAIKNT 509
            + +   L   +++ Q   D +L+ A             D +      A   L E+ + + 
Sbjct: 3601 NNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSR 3659

Query: 510  SG--------DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
             G         + AL  Q+ +  K L++    ++++E+ + S +        ++K     
Sbjct: 3660 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATK 3719

Query: 562  LGECSSSI--DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
            + +  + +    +K LE  LK+ E+   G   L S   +    +   E  +A+ L KE+ 
Sbjct: 3720 IDKVDTVMMGKKLKTLEVLLKDMEK---GHSLLKSAREKGERAVKYLEEGEAERLRKEIH 3776

Query: 620  -------------------MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
                               +++ L   ++F+    ++  W+ + +E L   +  E   ++
Sbjct: 3777 DHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--EPKMEL 3834

Query: 661  QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
               + Q+ K K LQ+ V   +  + S+        +    +   L+D++ Q+   +  +C
Sbjct: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL--VQDVTLKDKIDQLQSDYQDLC 3892

Query: 721  S----LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD--AEILQ 774
            S    ++EE  G  +D L   Q   +   G          ++N    +    D  + I  
Sbjct: 3893 SIGKAMMEEIAG-FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICS 3951

Query: 775  DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEV 834
               +    ++HEL +   R  +LQ   CQ  ++A   D   + +        +K +    
Sbjct: 3952 TAQRMYQSLEHELQKHVSRQDTLQ--QCQAWLSAVQPDLEPSPQPPLSRAEAIKQV---- 4005

Query: 835  SRHIKELEK----LLDVSSSQQDLSSWS 858
             +H + L++     LD+  S  DLS+ S
Sbjct: 4006 -KHFRALQEQARTYLDLLCSMCDLSNAS 4032



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 141/728 (19%), Positives = 273/728 (37%), Gaps = 177/728 (24%)

Query: 249  QRWDNLQKRVTSIL----RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SEC 302
            Q W    K +TS +       +  + Q  +F+T     L WL  +  +L+   +   +  
Sbjct: 4788 QSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQ 4847

Query: 303  DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY----- 357
            D+Q +I++++  Q+E+  +   +  +  + ++   K++ L +A +E  L EL        
Sbjct: 4848 DIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQ 4907

Query: 358  ---------CQEVFGRVERYHKKLIR-----------LPLPDDEHDLSDRELELEDS--- 394
                       E++ + +RY++               L L  +  D+   E  L+     
Sbjct: 4908 EALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF 4967

Query: 395  --------AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ-PLRSERSGRDTPASVDSI-- 443
                    + L +LH    + D L+ P    +L   +A   LRS+R  RD+ A VD +  
Sbjct: 4968 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027

Query: 444  -PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
               +W HDY  +R+           E  E  +D +  L      S +    S EA  KL+
Sbjct: 5028 CTAQW-HDYQKARE-----------EVIELMNDTEKKLS---EFSLLKTSSSHEAEEKLS 5072

Query: 503  ENAIKNTSGDHSALESQIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 559
            E         H AL S +    +   AL++   Q+++T N   SK      + T ++ + 
Sbjct: 5073 E---------HKALVSVVNSFHEKIVALEEKASQLEKTGN-DASKATLSRSMTTVWQRWT 5122

Query: 560  KL--------------LGECSSSIDSVKRLEHKLKEEEESLPG-------------FVNL 592
            +L              + E +   + VK+    + + ++ LPG              +  
Sbjct: 5123 RLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEY 5182

Query: 593  HST---------------ETQTAGVI----------------------DRWELLQAQALS 615
            H T                 QT  ++                      DR   +Q +  +
Sbjct: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT 5242

Query: 616  KELRMKQNLQKWQQFNSDLNSIWAWLGDTEE-----------ELEQLQRL--ELSTDIQT 662
                +KQ L+  +   + +NS+  W+ +T+E           +LE+LQ L  E +   Q 
Sbjct: 5243 NGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5302

Query: 663  IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
            IE   ++ KE    +       LS+ L        D K    +QD++ +           
Sbjct: 5303 IEKMAEEQKEKYLGLYTILPSELSLQLAE---VALDLKIRDQIQDKIKE----------- 5348

Query: 723  LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
            +E+ +   Q+   Q Q   +++  L  +L  +  + + +V   +  D ++L +   +L  
Sbjct: 5349 VEQSKATSQELSRQIQ---KLAKDLTTILTKLKAKTDNVV--QAKTDQKVLGE---ELDG 5400

Query: 783  IKHELLESQLRVASLQDMSCQL---LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
               +L+E    V    + + QL   L    G      ++ +    NRL   L + + H++
Sbjct: 5401 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS-KLNQAASHLE 5459

Query: 840  ELEKLLDV 847
            E  ++L++
Sbjct: 5460 EYNEMLEL 5467



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 152/743 (20%), Positives = 287/743 (38%), Gaps = 100/743 (13%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            E L   + +     ++  L ++++RW+ L  +I  R+  L+  +   QQ D+ + S   W
Sbjct: 1728 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1787

Query: 63   LAHIESELAK-----------PIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLN 110
            +    SEL              +     ++ E++ K  E Q LQ  + K  S G A  L+
Sbjct: 1788 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1847

Query: 111  LCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQK 165
            L +    DC     +A    +  Q A  +L    ++  ++S    + R  +E T  + + 
Sbjct: 1848 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1907

Query: 166  FLDDYSR-FEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 224
              D   +   D L++++   +   S   I + A+  LK   + QR    C    + +  +
Sbjct: 1908 ESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGE 1965

Query: 225  YRRL-----ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 279
              R+      +++  D+   LK+   +   + + L K +  I  R       +E    A 
Sbjct: 1966 VERIQNLLGTKQSEADALAVLKKAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQAL 2021

Query: 280  DSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQL 335
               L    +++ +L + EH   C ++ K KQ+     AF  E+    N++E      ++L
Sbjct: 2022 QQRLRVFNQLEDELNSHEH-ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2080

Query: 336  IEKSEPLDAAIIE--EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 393
            I +++     +I+   E   L+    +V   +E     ++      D+ DL  +    + 
Sbjct: 2081 IHENQGQCCGLIDLMREYQNLKSAVSKV---LENASSVIVTRTTIKDQEDL--KWAFSKH 2135

Query: 394  SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 453
              A + +++  +  D+  S        L             D  ++VD    +W    D+
Sbjct: 2136 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD----KW---LDV 2188

Query: 454  SRDLESAMSR----------ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            S  LE  M R           L + DE      +   + A  +S++      E  +K  E
Sbjct: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFE 2248

Query: 504  NAIKNTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
            + +KN +     L S++   ++L K L+     +Q  E  +  K     E+    KG +K
Sbjct: 2249 SEVKNKALRLEELHSKVNDLKELTKNLETPP-DLQFIEADLMQKLEHAKEITEVAKGTLK 2307

Query: 561  LLGECSSSIDS-VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
                 S+ ++  +  +     + EESL   +N    ET              +AL K   
Sbjct: 2308 DFTAQSTQVEKFINDITTWFTKVEESL---MNCAQNET-------------CEALKKVKD 2351

Query: 620  MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 679
            +++ LQ  QQ N         +  T+E L  L R   S +++++   +  L +  +AV  
Sbjct: 2352 IQKELQS-QQSN---------ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS- 2400

Query: 680  RKAIILSINLCSPEFTQADSKES 702
                     LCS   TQA  +ES
Sbjct: 2401 --------QLCSK--TQASLQES 2413



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 157/826 (19%), Positives = 311/826 (37%), Gaps = 150/826 (18%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHL-----------LDLIAARVKK----LKET 45
            M  ++A   H+  A+E+E K G++     HL           L L+  + +      +E 
Sbjct: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863

Query: 46   LVAVQQLDKNMSSLRTW------LAHIESELAKPI-VYDSCNSEE---IQRKLNEQQELQ 95
               V++    +S L  +      L+ I  +L + +   +S N  E   I++ LN+  +  
Sbjct: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923

Query: 96   RDIEKHSTGVASVLNLCEVLLH--------DCDACATDAECDSIQQATRNLDRRWRNICA 147
            + +E  +  +  +L+  +  L          C A A D  C  +++    L  +     A
Sbjct: 1924 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATA-DQLCGEVERIQNLLGTKQSEADA 1982

Query: 148  MSM------------------------ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 183
            +++                        + RLK E T +  Q+ L  +++ ED L S E  
Sbjct: 1983 LAVLKKAFQDQKEELLKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHE 2041

Query: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
              +      +   AK+  +K  AF  +V   + +LE+     +RL  EN+    C L  +
Sbjct: 2042 LCW------LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ-GQCCGLIDL 2094

Query: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL--------TEMDLQLTN 295
            + E    + NL+  V+ +L      I  R   +   D  L W          +M+ +  +
Sbjct: 2095 MRE----YQNLKSAVSKVLENASSVIVTRTTIKDQED--LKWAFSKHETAKNKMNYKQKD 2148

Query: 296  IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
            +++F+        +  K    + SL    +E  + +   + EK        +EE +D LR
Sbjct: 2149 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK--------LEENMDRLR 2200

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 415
                             + L + DD   LS R+ E+E         W +        PQ 
Sbjct: 2201 -----------------VSLSIWDDV--LSTRD-EIEG--------WSNNCV-----PQM 2227

Query: 416  SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 475
            + N+S +L   LR+E   ++  + V +  L  +  +    DL+        +++ E   D
Sbjct: 2228 AENIS-NLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKEL------TKNLETPPD 2280

Query: 476  KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535
              F         +  + +  E   ++TE A K T  D +A  +Q+ +     D + +  +
Sbjct: 2281 LQFI--------EADLMQKLEHAKEITEVA-KGTLKDFTAQSTQVEKF--INDITTWFTK 2329

Query: 536  QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 595
              E+++        E     K   K L    S+I S +   + L  +  S      L S 
Sbjct: 2330 VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESL 2385

Query: 596  ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW-LGDTEEELEQLQRL 654
                 G+I + E +       +  ++++L+K   F+  +     W LG      E   R 
Sbjct: 2386 GRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDR- 2442

Query: 655  ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE-SRDLQDRLSQMN 713
              + D + +E ++  L+ +  +V   ++ + ++           SK+    +Q+++++ N
Sbjct: 2443 --TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2500

Query: 714  GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
              +        + +  LQD   +   F +    L L +  ++ R N
Sbjct: 2501 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2546



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/372 (21%), Positives = 159/372 (42%), Gaps = 52/372 (13%)

Query: 531  RFQIQQTENIIRSKTPTGP--ELDTSYKGYMKLLGECSSSIDSVKRLE-------HKLKE 581
            RF+  + E ++R    TG   E   S+     L  E   + +  KR E       + +KE
Sbjct: 1351 RFETNK-ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE 1409

Query: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ-KWQQFNSDLNSIWAW 640
              E   G  N    + Q   + ++ + L+   L ++++  + ++ KW  F S+  ++  W
Sbjct: 1410 ASEIPLGPQNKQLLQQQAKSIKEQVKKLE-DTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1468

Query: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADS 699
            + + E+EL  L+     T    +++QI ++K   + ++ + + I+ +   +  F Q   +
Sbjct: 1469 ITEKEKELNALE-----TSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT 1523

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
             ES  ++ +L+Q+    + +    +   G +   L Q Q F E    L  + +++   ++
Sbjct: 1524 GESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEE---NLRKIQQSVSEFED 1580

Query: 760  EI-VPIDSNLDA----EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEG---- 810
            ++ VPI     A    ++LQ+H         + LES     +    S + +VN +     
Sbjct: 1581 KLAVPIKICSSATETYKVLQEHMDLC-----QALESLSSAITAFSASARKVVNRDSCVQE 1635

Query: 811  --------TDCL-EAKEKVHVIGNRL---KLLLKEVSRHIKELEK-LLDVSSSQQDLSSW 857
                     D L  AKE+   + N L   + L KE+S  +  LE+     SS + D+   
Sbjct: 1636 AAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDI--- 1692

Query: 858  SSADELDTSGSV 869
             SAD +   G +
Sbjct: 1693 -SADRVKVEGEL 1703



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)

Query: 581 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 640
           EE E++  F+N    ET       +W  L  +  S    +++ +  W ++ + + S+ AW
Sbjct: 585 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 635

Query: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
           L D E+ L Q +  +               + L   +    A+  + N         D  
Sbjct: 636 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 681

Query: 701 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 760
            SRDL+ +L  +NGR          WR L  +     Q             + +DR K E
Sbjct: 682 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 719

Query: 761 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800
                  L A   + H K    ++   +  +L +  L+D+
Sbjct: 720 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 759



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            ++W+ +  +A  +   +   +++WQ++      +  WL        ++  L +S  + ++
Sbjct: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 7522

Query: 664  ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715
             + +++ + L   V  ++ +        IL++         ADS     LQ  L+++  +
Sbjct: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582

Query: 716  WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
            W      LEE +  L   L   + + +   G+   LE +   K ++        ++ L D
Sbjct: 7583 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 7631

Query: 776  HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835
            HH++L   +    E +  V S  D   QL +  +      + + + ++  R++LL     
Sbjct: 7632 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 7687

Query: 836  RHIKELEKLLDVSSSQ--QDLSSWSSADE 862
            R  +EL   L +   Q  + L+ W+   E
Sbjct: 7688 RQWEELCHQLSLRRQQIGERLNEWAVFSE 7716



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)

Query: 606  WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
            W++LQ     K   ++  L+ W ++ +++  +  W    E+ L+Q  R+     +Q    
Sbjct: 6932 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 6991

Query: 666  QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725
              + L++L KA +     I    L   +  + D   S  +   L ++   W  +  ++ +
Sbjct: 6992 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 7049

Query: 726  WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             + LL+  L Q       F +++  L+    ++ R +     +  +L+A  +Q     L 
Sbjct: 7050 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 7103

Query: 782  QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841
             ++ +L + +  +     ++ QLL              +  +  R   LL+E++  ++  
Sbjct: 7104 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7163

Query: 842  EKLLDVSSSQQDLS 855
            + LL +    +D S
Sbjct: 7164 KALLQLWQRYKDYS 7177



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 53/276 (19%), Positives = 120/276 (43%), Gaps = 25/276 (9%)

Query: 609  LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 668
            L+A   S   ++ ++  KW+ + S  +   +W+   E +L+ ++   + T       ++K
Sbjct: 1115 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDT---ANHGEVK 1171

Query: 669  K-LKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEW 726
            + ++E++  V  R   +  +       T+  S+ E++   D L++++  +  + +LL E 
Sbjct: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231

Query: 727  RGLLQDALMQCQGFHEMSHGLLLML----ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
              +L +    C  + E+    L  L    + +  +  +I+  ++  +A+ L  HH+Q  +
Sbjct: 1232 EKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTK 1290

Query: 783  --------IKHELLESQLRVASLQDMSCQLLVNAEGT-DCLEAKEKVHVIGNRLKLLLKE 833
                    ++ ++ ++Q     L D   + L   E T D LE   +      R+++ L++
Sbjct: 1291 RISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ--ERRIQVTLRK 1348

Query: 834  VSRHIKELEK----LLDVSSSQQDLSSWSSADELDT 865
              R     E     L    SS +   S+SS + L +
Sbjct: 1349 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSS 1384



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 39/328 (11%)

Query: 51  QLDKNM----SSLRTWLAHIESELAKPIVYDSCNSEE---IQRKLNEQQELQRDIEKHST 103
           QLDK++     ++  WL   E  L + I     + E    IQRKL + ++L ++ + H  
Sbjct: 409 QLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKR 468

Query: 104 GVASVLNLCEV--LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 161
               +     V  +    D     AE      +T  L         M ME    +E  +R
Sbjct: 469 AFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELH-------LMKMEF---LELKYR 518

Query: 162 LWQKFLDDYSRFEDWL-KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLEL 220
           L    +   S+ + W+ K   R +        +  +  E  K FE ++          E+
Sbjct: 519 LLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFI--ENSKFFEQYEVTYQILKQTAEM 576

Query: 221 INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARD 280
             K       +   + A ++ + ++E   +W NL   V S+   L+  I   + +     
Sbjct: 577 YVKA------DGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVA 630

Query: 281 SILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
           S+  WL + +  L   E+ ++ D    +      QQ  ++N          G  LIE  +
Sbjct: 631 SLQAWLEDAEKMLNQSEN-AKKDFFRNLPHW--IQQHTAMND--------AGNFLIETCD 679

Query: 341 PLDAAIIEEELDELRRYCQEVFGRVERY 368
            + +  ++++L  L    +E+F  V++Y
Sbjct: 680 EMVSRDLKQQLLLLNGRWRELFMEVKQY 707



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 143/730 (19%), Positives = 288/730 (39%), Gaps = 91/730 (12%)

Query: 38   RVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI--QRKLNEQQELQ 95
            RV  L++T  A Q+ +K    L   L  ++ E +K       N E +  + KL     L 
Sbjct: 4698 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSK------VNEETLPAEEKLKMYHSLA 4751

Query: 96   RDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLK 155
              ++     +  V    E L    D  A +     IQ     L      I     E   +
Sbjct: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811

Query: 156  IEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 215
            + ++      F  + SR  DWL+  +   + P    +     +EE++K +  Q +V   L
Sbjct: 4812 MVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL 4867

Query: 216  TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 275
              +  ++ + +    + +   +  L+  + E ++   ++Q+ + +    L     Q + +
Sbjct: 4868 RIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927

Query: 276  ETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLN---HNKIEQ--- 327
                 +   WL +    LQL      +  DV++  + LK+  +  S     H+ +E+   
Sbjct: 4928 YQVFQAANDWLEDAQELLQLAG----NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHS 4983

Query: 328  IIAQGEQLIEKS--EPLDAAIIEEELD------------ELRRYCQEVFGRVERYHKKLI 373
            ++A  + LI+ +  E L+  +   EL             +L + C   +   ++  +++I
Sbjct: 4984 LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVI 5043

Query: 374  RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS--ER 431
             L + D E  LS+  L    S+  ++    +  A  L+S   S +  +   +   S  E+
Sbjct: 5044 EL-MNDTEKKLSEFSLLKTSSSHEAEEKLSEHKA--LVSVVNSFHEKIVALEEKASQLEK 5100

Query: 432  SGRDT-----PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
            +G D        S+ ++   W     +++D E  +  A+  ++  G ++K   ++ A  +
Sbjct: 5101 TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV--DEWTGFNNK---VKKATEM 5155

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGD-HSALESQIRQLGKALDDSRFQIQQTENIIR-SK 544
             D +  + P +  +    A   T  + H     ++ Q   AL   R   QQT ++++   
Sbjct: 5156 IDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR---QQTLSMLQDGA 5212

Query: 545  TPTGPELDTSYKGYMKLLGECSSSIDSVKR----LEHKLKEEE--ESLPGFVNLHSTETQ 598
             PT  E     +    +   C +  + VK     ++ +LK+ E  E+    V     ET+
Sbjct: 5213 APTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK 5272

Query: 599  ------TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                  T  +  + E LQ   L++    +QN++K  +   +      +LG     L  + 
Sbjct: 5273 EYLGNPTIEIDAQLEELQI-LLTEATNHRQNIEKMAEEQKE-----KYLG-----LYTIL 5321

Query: 653  RLELSTDIQTIELQIKKLKELQ---KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRL 709
              ELS  +  + L +K   ++Q   K V+  KA        S E ++   K ++DL   L
Sbjct: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKA-------TSQELSRQIQKLAKDLTTIL 5374

Query: 710  SQMNGRWDRV 719
            +++  + D V
Sbjct: 5375 TKLKAKTDNV 5384



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 59/369 (15%), Positives = 151/369 (40%), Gaps = 43/369 (11%)

Query: 13  KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
           +A  +   + +   +W++L   + +    L+E +    +    ++SL+ WL         
Sbjct: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWL--------- 636

Query: 73  PIVYDSCNSEEIQRKLNEQQELQRD--------IEKHSTGVASVLNLCEVLLHDCDACAT 124
                    E+ ++ LN+ +  ++D        I++H+    ++ +    L+  CD   +
Sbjct: 637 ---------EDAEKMLNQSENAKKDFFRNLPHWIQQHT----AMNDAGNFLIETCDEMVS 683

Query: 125 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
                 ++Q    L+ RWR +  M +++  + +E  R+ +++ D       +   + +  
Sbjct: 684 ----RDLKQQLLLLNGRWREL-FMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKL 738

Query: 185 AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV 244
           + P    V +   K  ++  E  +++V     Q ++I K    + +E+  +    +   +
Sbjct: 739 SEPLE--VSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796

Query: 245 HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDV 304
            +  ++   +++  + +L   +  +   EE E    S    L +++  +T +E  ++   
Sbjct: 797 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 856

Query: 305 --QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
             + K ++L A Q+    N  K   +I +G Q ++K   L   +   +   L+R   ++ 
Sbjct: 857 LFKQKHQELLACQE----NCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 912

Query: 363 GRVERYHKK 371
              +   KK
Sbjct: 913 VAFQSMVKK 921



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)

Query: 3    ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            +RL +  +    ++ E K +  +N  W  +      R  KL+  L+  Q   +   +   
Sbjct: 7340 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 7399

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            +L   E +LA  I   S N + +  +    +  Q ++      + S++   + LL     
Sbjct: 7400 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 7456

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179
                 + D        L  +W+ +   + +RR  I+   R WQ++ +   +   WL    
Sbjct: 7457 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 7512

Query: 180  ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
                    + P       T+  E   K + F RQ    +  +E      ++L     + +
Sbjct: 7513 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 7568

Query: 237  ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
              +L+  + E  ++W +   R+    ++L   +   E+ E      L  L     +L+  
Sbjct: 7569 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7628

Query: 297  EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                  ++ A+  + K  +  +    + + Q+    + L       D +I+ E ++ L+R
Sbjct: 7629 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7688

Query: 357  YCQEV 361
              +E+
Sbjct: 7689 QWEEL 7693



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 139/775 (17%), Positives = 298/775 (38%), Gaps = 106/775 (13%)

Query: 13   KASEIEYKLGKVNDRW-QHLLDLIAARVKKLKETL---VAVQQLDK--------NMSSLR 60
            +ASEI   LG  N +  Q     I  +VKKL++TL   +   ++ K        N  +L 
Sbjct: 1409 EASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1466

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
             W+   E EL       S    +I +     QE++  +     G+          +   +
Sbjct: 1467 VWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS-IVGLEEEAQSFAQFVTTGE 1525

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAM---SMERRLKIEETWRLWQKFLDDYSRFEDWL 177
            +    A+   I++    L    + +       + ++ K EE  R   K     S FED L
Sbjct: 1526 SARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLR---KIQQSVSEFEDKL 1582

Query: 178  KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
                +     SS+   Y V +E +   +A +  +   +T      ++   + R++    A
Sbjct: 1583 AVPIKIC---SSATETYKVLQEHMDLCQALE-SLSSAITAFSASARKV--VNRDSCVQEA 1636

Query: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
             +L+Q       +++++ +R       L++ +   +  E    S L WL   + + ++ E
Sbjct: 1637 AALQQ-------QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1689

Query: 298  HFSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---EEL 351
                 D   V+ +++ ++A Q E+    +   +++   E L   +   D  +++   E+L
Sbjct: 1690 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1749

Query: 352  DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL 411
            DE  R   ++  +   + + ++       EH   D  L       LS   W       L 
Sbjct: 1750 DERWRDLPQIINKRINFLQSVVA------EHQQFDELL-------LSFSVWIKLFLSEL- 1795

Query: 412  SPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
              Q +S +S+   Q   +    +D  A V+S             +L+S     L      
Sbjct: 1796 --QTTSEISIMDHQVALTRH--KDHAAEVES----------KKGELQSLQGH-LAKLGSL 1840

Query: 472  GQDDKDFYLRGAVGLSDVMIPESPEAYVK--LTENAIKNTSGDHSALESQIRQLGKALDD 529
            G+ +    L+G       +  E+ +   +  L  + +      H++L   +RQL + ++ 
Sbjct: 1841 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1900

Query: 530  SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV-KRLEHKLKEEEESLPG 588
            +    +   ++I        +L+ + +   K L   + S+D +  + ++ LK        
Sbjct: 1901 TNSMNKNESDLIEK------DLNDALQN-AKALESAAVSLDGILSKAQYHLK-------- 1945

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW--AWLGDTEE 646
               + S+E +T+          A  L  E+   QNL   +Q  +D  ++   A+    EE
Sbjct: 1946 ---IGSSEQRTSC------RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEE 1996

Query: 647  ELEQLQRLELSTDI--------QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
             L+ ++ +E  TD         Q ++ +++   +L+  ++  +  +  +   + +  Q D
Sbjct: 1997 LLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2056

Query: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 753
               + ++   ++++   WD    L+ E +G     +   + +  +   +  +LEN
Sbjct: 2057 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN 2111



 Score = 35.4 bits (80), Expect = 0.26
 Identities = 53/282 (18%), Positives = 123/282 (43%), Gaps = 29/282 (10%)

Query: 596  ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 655
            +TQ   + + W  + + ++  +  ++  + +W  +    N +  W+   ++++E    L+
Sbjct: 2711 QTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQ 2768

Query: 656  LSTDIQTIELQIKKLKE-LQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQM 712
                ++   + +  L+  L +A DH +A+  +++ +    E T+ +S +    ++  +Q 
Sbjct: 2769 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQF 2828

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            N         + +   +++D LM     HE +  L    E + R        D + D+  
Sbjct: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS------DMSGDSSA 2882

Query: 773  LQDHHKQLMQIKHELLESQ----LRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
             Q   K+L +IK EL++S+     R++ ++ ++ ++  N   + C    E +H     L+
Sbjct: 2883 TQ---KKLSKIK-ELIDSREIGASRLSRVESLAPEVKQNTTASGC----ELMHTEMQALR 2934

Query: 829  LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVS 870
               K+    + + +  L+   SQ  LS      E + SG V+
Sbjct: 2935 ADWKQWEDSVFQTQSCLENLVSQMALS------EQEFSGQVA 2970


>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
            [Homo sapiens]
          Length = 3321

 Score = 1890 bits (4895), Expect = 0.0
 Identities = 959/982 (97%), Positives = 959/982 (97%), Gaps = 23/982 (2%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 2363 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 2422

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 2423 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 2482

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 2483 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 2542

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 2543 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 2602

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 2603 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 2662

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 2663 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 2722

Query: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
            VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 2723 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 2782

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
            LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 2783 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 2842

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
            RGAVGL                       SGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 2843 RGAVGL-----------------------SGDHSALESQIRQLGKALDDSRFQIQQTENI 2879

Query: 541  IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
            IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 2880 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 2939

Query: 601  GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
            GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 2940 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 2999

Query: 661  QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
            QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 3000 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 3059

Query: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
            SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 3060 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 3119

Query: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
            MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 3120 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 3179

Query: 841  LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
            LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 3180 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 3239

Query: 901  HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
            HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 3240 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 3299

Query: 961  LSNNFARSFHPMLRYTNGPPPL 982
            LSNNFARSFHPMLRYTNGPPPL
Sbjct: 3300 LSNNFARSFHPMLRYTNGPPPL 3321



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G++L  ++     + ++ +L ++ ++W+     +  + KKL   L   ++ +K ++    
Sbjct: 2152 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 2211

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
             L   + +L++ +        +   +L+ +Q   +++E         L    +L     A
Sbjct: 2212 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 2264

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
              +  +   + +    L R+W  +C     RR +I E    W  F +      +WL   E
Sbjct: 2265 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 2324

Query: 182  RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241
               +   +  ++     E+LKK   +Q ++         + +   RLA+ +    A  ++
Sbjct: 2325 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 2380

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301
              + + N RW +L   + + +++LK  +   ++ +    S+  WL  ++ +L     +  
Sbjct: 2381 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 2440

Query: 302  C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
            C   ++Q K+ + +  Q++I  +   +  ++   E L+      DA   + E D +++
Sbjct: 2441 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 2495



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)

Query: 4    RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60
            +L K  H      +   L +VN RW +LL+ IA +++  K  L   Q+     K  +S  
Sbjct: 1720 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 1779

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
                   +EL K         +E+   + +  +L + +      +  +  L E L    D
Sbjct: 1780 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 1839

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177
            A A  A    IQ    +L    +++CA+     +++  ++     ++ F       E W+
Sbjct: 1840 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 1892

Query: 178  KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
              +E       PS S  + T+ +E +++ +    +       L+ +N+   RL   ++  
Sbjct: 1893 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 1949

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294
                +K+M    N+ W  +  + T    +L+ F+ Q + F    ++ + +L + + +L  
Sbjct: 1950 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 2005

Query: 295  ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
                N +H  E   Q +  +L  FQ E+      +  II  G++L+E+ +  D      +
Sbjct: 2006 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 2060

Query: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
            L  L    Q V  R ++      R  + D +     R  E+ +           R     
Sbjct: 2061 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 2105

Query: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
            +S  P S L  S+  PL+  R+  D     + + L     Y L+ +    +  +  S  E
Sbjct: 2106 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 2164

Query: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
                 +   ++     + + + E  +    L ++  K   G   +LE ++R   K L  S
Sbjct: 2165 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 2223

Query: 531  -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579
                       + + ++ EN + S T      D +    +K       S D +  L  ++
Sbjct: 2224 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 2278

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
            +  +                     +WE L  Q   +  ++ + L +W  F+     +  
Sbjct: 2279 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 2318

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698
            WL   E ++ Q      + DI   E+  K  K+ Q+ +   +   + +        +A  
Sbjct: 2319 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 2372

Query: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
              ++ +++ +L ++N RW  +  L+      L++ L+  Q   +    L   L +I+   
Sbjct: 2373 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 2432

Query: 759  NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807
             + +  DS  ++E +Q    +  +++ ++ +    VAS+ ++ C++L++
Sbjct: 2433 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 2479



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)

Query: 15   SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71
            S++E +L ++ + W    + ++  + +L+  L    +     + L  WL   +  L    
Sbjct: 1287 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 1346

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +  V      E ++  LN   E  ++++  S+  +SVL+    LL          +  ++
Sbjct: 1347 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 1401

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190
            +     +D +W ++       + K+ +            S    W+   E        + 
Sbjct: 1402 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 1461

Query: 191  --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241
               + Y    E L+K++ F+  ++     ++ +N+   +++       R ++TD A  L 
Sbjct: 1462 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 1521

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300
             M    N+ W  LQ  VT  ++ L+  +    E+E     +  W    + +L        
Sbjct: 1522 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 1577

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            +  VQ  +K  +  +  I     ++E+I   G  LI+  +   ++I+   L EL +    
Sbjct: 1578 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 1637

Query: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
            +                   +H +   ++ L+  + L     H  + D + S    +  S
Sbjct: 1638 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 1676

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
            LS  + L           S++++ ++ D+  +L  DLE                 ++  L
Sbjct: 1677 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 1711

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529
            +    +++ ++ E      +   N +K  +   + L  +I    Q  KAL        D 
Sbjct: 1712 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 1771

Query: 530  SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
            S+     +QQ E+      K  T  ++ D     +++   +    + +VK     L E  
Sbjct: 1772 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 1831

Query: 584  ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640
            E L   V+  +     +  +   + L A  QAL K +  ++  +  ++ F   L ++ AW
Sbjct: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 1891

Query: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
            + + EE L Q Q    S+D+ TI+ ++++L          K  +L  +  +P+  + +  
Sbjct: 1892 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 1940

Query: 701  ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
              R  L D    R+  +N  W  + S   E    LQ  L+Q Q F          LE  +
Sbjct: 1941 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 1990

Query: 756  RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792
                 +V  +  L  EI  ++   L Q + HEL ++++
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 2028



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+RL +        E   KL  ++++WQ ++     R   +   +   Q+  +    LR 
Sbjct: 2042 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 2101

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            WL  +       +       ++ +   +E Q  ++   +        +   + LL   D+
Sbjct: 2102 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 2161

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
             A  A    +Q     +  +W++      E++ K+    + W+K     +   + L++ +
Sbjct: 2162 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 2217

Query: 182  R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +  + + P     ++   +   K+ E       + LTQL L+      L+     D    
Sbjct: 2218 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 2273

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
            L + V    ++W+ L  +++   +++   + +   F      +  WLT+M+   + +   
Sbjct: 2274 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 2330

Query: 300  SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
             +  ++  I++LK  +Q+EI++      Q+   GE+L + S    A+ IE +L ++    
Sbjct: 2331 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 2390

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
            Q +   +    KKL                   E   A+  L   D++  SL +    ++
Sbjct: 2391 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 2427

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476
            +   LA+P+  +        + + I  + +   +L RD+E  S    ++ +  E    D 
Sbjct: 2428 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 2481

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533
            D     A   S   I ++     +   N    +      +E   R   K LDD SRF+  
Sbjct: 2482 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 2538

Query: 534  IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587
            ++ +E      + +G       E    ++ + + + EC + ++ + +   +L  E  +  
Sbjct: 2539 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 2596

Query: 588  GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647
               +  S +        RW+ LQ +  S   R+K  + + ++F +  +SI  WL + + +
Sbjct: 2597 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 2654

Query: 648  LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681
            L  ++      D+Q    +IK+LK  Q+  +++H K
Sbjct: 2655 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 2686



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 142/799 (17%), Positives = 312/799 (39%), Gaps = 95/799 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            +L K+ D +  L+ +I +R   L + L    Q ++ +  L   L   + ++A        
Sbjct: 1083 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 1142

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            + EEIQ+ L++ +E  + +E H       + L E L     + A   E     Q    L 
Sbjct: 1143 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 1191

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             +   +   + +R +++E     W   LD     ED  + S +     SS   +  V + 
Sbjct: 1192 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 1245

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256
            E +  +      H   +  E   K Y+ L    R   + S   L+  +++  + W +   
Sbjct: 1246 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 1305

Query: 257  RVTSILRR----LKHFIGQREE-------FETARDSILVWLTEMDLQLTNIEHFSECDVQ 305
            +++  L R    LKH+   + E        ++A+D +  W  +       +E      V+
Sbjct: 1306 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEM-----VR 1360

Query: 306  AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 365
              +     F +E+    +    +++ G QL+ + + +D A +  EL  +     ++   +
Sbjct: 1361 DHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNI 1419

Query: 366  ERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQ 425
                +KL +L +            +L    A+S++       ++++  +   N+  S+  
Sbjct: 1420 PAVQEKLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGY 1467

Query: 426  PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-G 482
                E   +     +D       +   L+ D  +     + S+D E +  D  DF  + G
Sbjct: 1468 KAIHEYLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 1521

Query: 483  AVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
            A+  S  ++       ++L E  +++     S  E+ ++ L    +    +++Q   I  
Sbjct: 1522 AMNKSWQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI-- 1575

Query: 543  SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 602
                               L +C    D +K  E ++++ E++  G   + + +   + +
Sbjct: 1576 ----------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSI 1623

Query: 603  I--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL 654
            +          W  L       ++ +K  L +W       + I ++L +    L + +  
Sbjct: 1624 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL- 1682

Query: 655  ELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMN 713
             L+  ++ +++Q+  L+ LQ  ++ ++  +    ++ +    +     +  L + L ++N
Sbjct: 1683 -LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVN 1741

Query: 714  GRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA 770
             RW+   +LLEE    LQ   AL+Q  Q + + S      ++  + R NE++   +N D 
Sbjct: 1742 MRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD- 1797

Query: 771  EILQDHHKQLMQIKHELLE 789
             I  D     +Q  ++LL+
Sbjct: 1798 -IADDEVATWIQDCNDLLK 1815



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)

Query: 527  LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
            LD+ + ++ +   ++ S  P+     E +      + L     SS++  +   +++ ++ 
Sbjct: 1218 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277

Query: 584  ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642
            + L   ++    E+Q   + + W L     +SKEL R++  L+ W ++ S+   +  WL 
Sbjct: 1278 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 1336

Query: 643  DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
              ++ LE    Q + +  +++ +   +    E  K VD + ++  S+     +  +    
Sbjct: 1337 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 1396

Query: 701  ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
            ++  L+  LS+++ +W      + ++ E+   L  D L       E+   + LM EN+ +
Sbjct: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 1455

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813
            +  +   I +++  + + ++ ++    K ++   QL V  +     Q+    V ++ +D 
Sbjct: 1456 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 1513

Query: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862
             +  E++  +    ++L   V+  I+ LE LL    +  ++ Q L +W    E
Sbjct: 1514 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 1566



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
            S  S  ++   +LG +N  WQ L  L+  +++ L+  L +  + + N+  L+TW    E 
Sbjct: 1508 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 1567

Query: 69   ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120
             L +   +   +   +Q  L + Q+L       ++++EK    G+A + N  E       
Sbjct: 1568 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 1618

Query: 121  ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
                  +  SI  +T R L + W N+  M  + ++ ++     W      + +   +L  
Sbjct: 1619 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 1672

Query: 180  SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
            +  + + F   +G +  V + ++   +  Q  + +    L+       +L +E       
Sbjct: 1673 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 1731

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLK 266
            +L   + E N RW+NL + +   L+  K
Sbjct: 1732 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 1759



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76
            KLG +   W+ L ++I+ + + L E L   Q+   ++ S+ T +  IE   SE  +P   
Sbjct: 460  KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 519

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                  E Q  ++E   LQ +I +  + +A      E++   C+  A  AE  ++Q    
Sbjct: 520  PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 572

Query: 137  NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183
             L  R   I   +  +R  +EE            +  Q++  +    + WL S++    T
Sbjct: 573  VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 632

Query: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
            A  P    +       + +       Q    L++L + N+      + +  D A  L   
Sbjct: 633  ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 692

Query: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298
            +         LQ+ +      ++    ++EE +     T    +  WL +     T    
Sbjct: 693  LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 749

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350
                  Q+ ++Q K  +QE++   + +  + ++GE+++ +    + +        ++ +E
Sbjct: 750  ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 805

Query: 351  L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398
            L          D++R   + +        K L  +   + E  L  R   L     L   
Sbjct: 806  LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 865

Query: 399  DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451
            D+   D+SA  SLL        + SS    +  Q +  E+   D  ++  +    W  D 
Sbjct: 866  DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 921

Query: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501
            +    + +A+   LP E E    +++   +    +S+ M           PE+ +    +
Sbjct: 922  EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 977

Query: 502  TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
             E+ +    G  S L+S + Q    + +   QI   +N +  K       D  Y    KL
Sbjct: 978  IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 1035

Query: 562  LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607
                    +  I+++++ E  LKE +    G + L            +  + + + D ++
Sbjct: 1036 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 1092

Query: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
             L     S+   + QNL    Q+   L  +   L   +E++   Q++ +S+  +  +L  
Sbjct: 1093 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 1152

Query: 668  KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721
            K  +  Q    H   +IL+  L     + A  KE++   + ++Q +    R         
Sbjct: 1153 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 1209

Query: 722  -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
             +LE W  L +D         E+S      LE ++     +  ++ N D   L D     
Sbjct: 1210 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 1256

Query: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
              +K  L E Q ++  + D   +LL++     C + + +++ +G        ++S+ +  
Sbjct: 1257 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 1313

Query: 841  LEKLLD----VSSSQQDLSSW--SSADELD 864
            LE +L       S   DL  W  S+ D L+
Sbjct: 1314 LETILKHWTRYQSESADLIHWLQSAKDRLE 1343



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            ++W+ +  +A  +   +   +++WQ++      +  WL        ++  L +S  + ++
Sbjct: 2066 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 2117

Query: 664  ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715
             + +++ + L   V  ++ +        IL++         ADS     LQ  L+++  +
Sbjct: 2118 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 2177

Query: 716  WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
            W      LEE +  L   L   + + +   G+   LE +   K ++        ++ L D
Sbjct: 2178 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 2226

Query: 776  HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835
            HH++L   +    E +  V S  D   QL +  +      + + + ++  R++LL     
Sbjct: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 2282

Query: 836  RHIKELEKLLDVSSSQ--QDLSSWSSADE 862
            R  +EL   L +   Q  + L+ W+   E
Sbjct: 2283 RQWEELCHQLSLRRQQIGERLNEWAVFSE 2311



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)

Query: 606  WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
            W++LQ     K   ++  L+ W ++ +++  +  W    E+ L+Q  R+     +Q    
Sbjct: 1527 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 1586

Query: 666  QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725
              + L++L KA +     I    L   +  + D   S  +   L ++   W  +  ++ +
Sbjct: 1587 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 1644

Query: 726  WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             + LL+  L Q       F +++  L+    ++ R +     +  +L+A  +Q     L 
Sbjct: 1645 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 1698

Query: 782  QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841
             ++ +L + +  +     ++ QLL              +  +  R   LL+E++  ++  
Sbjct: 1699 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 1758

Query: 842  EKLLDVSSSQQDLS 855
            + LL +    +D S
Sbjct: 1759 KALLQLWQRYKDYS 1772



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)

Query: 3    ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            +RL +  +    ++ E K +  +N  W  +      R  KL+  L+  Q   +   +   
Sbjct: 1935 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 1994

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            +L   E +LA  I   S N + +  +    +  Q ++      + S++   + LL     
Sbjct: 1995 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 2051

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179
                 + D        L  +W+ +   + +RR  I+   R WQ++ +   +   WL    
Sbjct: 2052 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 2107

Query: 180  ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
                    + P       T+  E   K + F RQ    +  +E      ++L     + +
Sbjct: 2108 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 2163

Query: 237  ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
              +L+  + E  ++W +   R+    ++L   +   E+ E      L  L     +L+  
Sbjct: 2164 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 2223

Query: 297  EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                  ++ A+  + K  +  +    + + Q+    + L       D +I+ E ++ L+R
Sbjct: 2224 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 2283

Query: 357  YCQEV 361
              +E+
Sbjct: 2284 QWEEL 2288



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 8/103 (7%)

Query: 42  LKETLVAVQQLDKNMSSLRTWL--AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 99
           ++  +V  +Q ++ M  L+  +  AH E E  KP+   + N +E+Q +++  +EL + I+
Sbjct: 257 MQAAVVQYEQYEQEMKHLQQLIEGAHREIE-DKPVA--TSNIQELQAQISRHEELAQKIK 313

Query: 100 KHSTGVASVLNLCEVL---LHDCDACATDAECDSIQQATRNLD 139
            +   +AS+ + C++L           T  E + + + T +LD
Sbjct: 314 GYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 356


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 1890 bits (4895), Expect = 0.0
 Identities = 959/982 (97%), Positives = 959/982 (97%), Gaps = 23/982 (2%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 7839 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7898

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 7899 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7958

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 7959 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 8018

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 8019 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8078

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 8079 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8138

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 8139 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8198

Query: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
            VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 8199 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 8258

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
            LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 8259 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8318

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
            RGAVGL                       SGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 8319 RGAVGL-----------------------SGDHSALESQIRQLGKALDDSRFQIQQTENI 8355

Query: 541  IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
            IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 8356 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8415

Query: 601  GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
            GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 8416 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8475

Query: 661  QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
            QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 8476 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535

Query: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
            SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595

Query: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
            MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655

Query: 841  LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
            LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715

Query: 901  HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
            HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8775

Query: 961  LSNNFARSFHPMLRYTNGPPPL 982
            LSNNFARSFHPMLRYTNGPPPL
Sbjct: 8776 LSNNFARSFHPMLRYTNGPPPL 8797



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 136/853 (15%), Positives = 335/853 (39%), Gaps = 71/853 (8%)

Query: 21   LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCN 80
            L  +   WQ     ++    +    +  ++ +++    +  WL   E +++ P      N
Sbjct: 3572 LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS-PRTRRQSN 3630

Query: 81   SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 140
                + +L++ ++   ++  +   V  V    + +L +    +    C + Q     L  
Sbjct: 3631 RATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMG-CQATQ-----LTS 3684

Query: 141  RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS--GVIYTVAK 198
            R++ +    +E+   +EE  +  ++     S + DW  S+ +     ++    V   +  
Sbjct: 3685 RYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMG 3744

Query: 199  EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 258
            ++LK  E   + + +  + L+   ++  R  +      A  L++ +H+  ++   L   V
Sbjct: 3745 KKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV 3804

Query: 259  TSILRRLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L+  +   +EF     ++  W+ E    L +         + +A++ + K+ QQ
Sbjct: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 376
             +  +   ++ +  +GE L+E  + +    +++++D+L+   Q++   + + H   +   
Sbjct: 3865 TVLSHEPSVKSVREKGEALLELVQDVT---LKDKIDQLQSDYQDLCS-IGKEHVFSLEAK 3920

Query: 377  LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL-SLAQPLRSERSGRD 435
            + D E    D   EL++        W  + +  L++P      SL ++ Q L   ++  +
Sbjct: 3921 VKDHE----DYNSELQEVEK-----WLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME 3971

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
              A  +      D   +L    ++ + +       + + +   +L+G       +   + 
Sbjct: 3972 EIAGFE------DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ 4025

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY 555
              Y  L     K+ S          RQ      D+  Q Q   + ++      P+   S 
Sbjct: 4026 RMYQSLEHELQKHVS----------RQ------DTLQQCQAWLSAVQPDLEPSPQPPLSR 4069

Query: 556  KGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELLQAQAL 614
                    E    +   + L+ + +   + L    +L +   +T A  I + E    Q +
Sbjct: 4070 -------AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QTI 4118

Query: 615  SKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 673
             ++L   QNL Q W++     + +W +L D +++L+ ++R     ++   +  + ++K+ 
Sbjct: 4119 EQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178

Query: 674  QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 733
             K +  ++A   S+N    +  +   KE       ++ +N +W  +C          ++ 
Sbjct: 4179 VKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4235

Query: 734  LMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 793
            L + + +H+  + + + LE      + +    +  DAE    H + L ++   L E +  
Sbjct: 4236 LQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQERKYA 4291

Query: 794  VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKLLDVSS 849
            +  L+D   +++ +    D    KE+   +  R      L+ +++   +  LE+L  V S
Sbjct: 4292 IEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQS 4351

Query: 850  SQQDLSSWSSADE 862
              Q+L  W+   +
Sbjct: 4352 RFQELMEWAEEQQ 4364



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 155/845 (18%), Positives = 337/845 (39%), Gaps = 72/845 (8%)

Query: 50   QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 109
            Q+ ++N+  ++  ++  E +LA PI   S ++ E  + L E  +L + +E  S+ + +  
Sbjct: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICS-SATETYKVLQEHMDLCQALESLSSAITAFS 1613

Query: 110  NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 169
                 +++  D+C  +A           L +++ +I   + ER+  +E     WQ+   +
Sbjct: 1614 ASARKVVNR-DSCVQEAAA---------LQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663

Query: 170  YSRFEDWLKSSERTAAFPSSSGVIYTVAKE-ELKKFEAFQRQVHECLTQLELINKQYRRL 228
             S F  WL+  E  A+ P        V  E EL+  +A Q +V    +    + +    L
Sbjct: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723

Query: 229  ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTE 288
                  D    +K  + + ++RW +L + +   +  L+  + + ++F+    S  VW+  
Sbjct: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783

Query: 289  MDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
               +L      S  D Q  + + K    E+     +++ +     +L       D  +++
Sbjct: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH--------------DLSDRELELEDS 394
             + ++  +  +E    VER    L  L      H              + ++   + E  
Sbjct: 1844 GKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESD 1903

Query: 395  AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ---PLRSERSGRDTPASVDSIPLEWDHDY 451
                DL+   ++A +L S   S +  LS AQ    + S        A+ D +  E +   
Sbjct: 1904 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1963

Query: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 511
            +L    +S  + AL    +  QD K+  L+    + D+      E   + T  A++    
Sbjct: 1964 NLLGTKQSE-ADALAVLKKAFQDQKEELLK---SIEDIEERTDKERLKEPTRQALQQRLR 2019

Query: 512  DHSALESQIRQLGKA---LDDSRFQIQQTENIIRSKTPTG-PELDTSYKGYMKLL----G 563
              + LE ++         L D   QI Q +     +       L+ ++    +L+    G
Sbjct: 2020 VFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQG 2079

Query: 564  ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID-RWELLQAQALSKELRMKQ 622
            +C   ID ++  ++      + L    ++  T T      D +W   + +    ++  KQ
Sbjct: 2080 QCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2139

Query: 623  NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKK-LKELQKAVDHRK 681
                      DL++  +       EL+++   + S     +E  + K L   +K  ++  
Sbjct: 2140 ---------KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2190

Query: 682  AIILSINLCSPEFTQADSKES------RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 735
             + +S+++     +  D  E         + + +S ++    R   LL+E+   +++  +
Sbjct: 2191 RLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-RAEELLKEFESEVKNKAL 2249

Query: 736  QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ--DHHKQLMQIKHELLESQLR 793
            + +  H   + L  + +N+     E  P    ++A+++Q  +H K++     E+ +  L+
Sbjct: 2250 RLEELHSKVNDLKELTKNL-----ETPPDLQFIEADLMQKLEHAKEIT----EVAKGTLK 2300

Query: 794  VASLQDMSCQLLVNAEGTDCLEAKEK-VHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQ 851
              + Q    +  +N   T   + +E  ++   N     LK+V    KEL+ +  ++SS+Q
Sbjct: 2301 DFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQ 2360

Query: 852  QDLSS 856
            ++L+S
Sbjct: 2361 ENLNS 2365



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G++L  ++     + ++ +L ++ ++W+     +  + KKL   L   ++ +K ++    
Sbjct: 7628 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 7687

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
             L   + +L++ +        +   +L+ +Q   +++E         L    +L     A
Sbjct: 7688 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
              +  +   + +    L R+W  +C     RR +I E    W  F +      +WL   E
Sbjct: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800

Query: 182  RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241
               +   +  ++     E+LKK   +Q ++         + +   RLA+ +    A  ++
Sbjct: 7801 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 7856

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301
              + + N RW +L   + + +++LK  +   ++ +    S+  WL  ++ +L     +  
Sbjct: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7916

Query: 302  C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
            C   ++Q K+ + +  Q++I  +   +  ++   E L+      DA   + E D +++
Sbjct: 7917 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 7971



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 150/846 (17%), Positives = 321/846 (37%), Gaps = 109/846 (12%)

Query: 29   QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKL 88
            +  L+  +A +K   + L  ++  + +   +  W  H   E+   +      +E+++ +L
Sbjct: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECW--HKGQEILDALQKAEPRTEDLKSQL 3023

Query: 89   NEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 148
            NE     RD+  +S  V+ ++       ++C        C + +Q               
Sbjct: 3024 NELCRFSRDLSTYSGKVSGLIKE-----YNCLCLQASKGCQNKEQI-------------- 3064

Query: 149  SMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQ 208
                         L Q+F   +  F+ WL +++ T A         +     L+K + F 
Sbjct: 3065 -------------LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFL 3111

Query: 209  RQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 268
             +      +L ++  +   L+     + A  ++  V    + W N    +      L++ 
Sbjct: 3112 SESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENL 3171

Query: 269  IGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKI 325
              Q ++FE + + I  WL++ + ++ +       D+ AK ++ +  Q   +EI     ++
Sbjct: 3172 KIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230

Query: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
             ++  + +QL E      +      + +L      +    +    +L R+    ++  L 
Sbjct: 3231 NRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLG 3288

Query: 386  DRELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 443
             +EL+  + D+  + D + H  S  S+L  + +  L   L+     E   +      +S+
Sbjct: 3289 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV 3347

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
                         L++     +P+  ++ Q  KD +      L    I           +
Sbjct: 3348 -------------LQNTSPEGIPTIQQQLQSVKDMW----ASLLSAGIR---------CK 3381

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMK 560
            + ++      ++ +  +RQ    +D     + ++E     +R KT        +  G  K
Sbjct: 3382 SQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAK 3433

Query: 561  LLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRM 620
            LL E   S  S+      L+  E    G    + T+ +   + +R+  +Q +A     + 
Sbjct: 3434 LLNEEVLSYSSL------LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487

Query: 621  KQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR 680
            ++ ++  Q++  DL +   WLG  +E+L+Q   LE   D  T E  ++ L+ELQ      
Sbjct: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEG 3545

Query: 681  KAIILSINLCSPEFTQA--DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 738
            +A++ S+     +   +     E R L+           R+     ++  ++    +  Q
Sbjct: 3546 QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605

Query: 739  GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH-----HKQLMQIKHELLESQLR 793
             F ++   L    E +  R        SN   + +Q H     H+++   + E+ E   R
Sbjct: 3606 KFQQVDEWLKTAEEKVSPRTRR----QSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGAR 3661

Query: 794  VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQ 852
               + D S    VN+    C   +     + +R + LL +V   IK L E++  +  S+ 
Sbjct: 3662 AQEILDES---HVNSR-MGCQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESES 3712

Query: 853  DLSSWS 858
             LSS+S
Sbjct: 3713 SLSSYS 3718



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)

Query: 4    RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60
            +L K  H      +   L +VN RW +LL+ IA +++  K  L   Q+     K  +S  
Sbjct: 7196 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 7255

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
                   +EL K         +E+   + +  +L + +      +  +  L E L    D
Sbjct: 7256 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 7315

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177
            A A  A    IQ    +L    +++CA+     +++  ++     ++ F       E W+
Sbjct: 7316 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7368

Query: 178  KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
              +E       PS S  + T+ +E +++ +    +       L+ +N+   RL   ++  
Sbjct: 7369 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 7425

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294
                +K+M    N+ W  +  + T    +L+ F+ Q + F    ++ + +L + + +L  
Sbjct: 7426 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7481

Query: 295  ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
                N +H  E   Q +  +L  FQ E+      +  II  G++L+E+ +  D      +
Sbjct: 7482 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7536

Query: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
            L  L    Q V  R ++      R  + D +     R  E+ +           R     
Sbjct: 7537 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 7581

Query: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
            +S  P S L  S+  PL+  R+  D     + + L     Y L+ +    +  +  S  E
Sbjct: 7582 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 7640

Query: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
                 +   ++     + + + E  +    L ++  K   G   +LE ++R   K L  S
Sbjct: 7641 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 7699

Query: 531  -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579
                       + + ++ EN + S T      D +    +K       S D +  L  ++
Sbjct: 7700 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 7754

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
            +  +                     +WE L  Q   +  ++ + L +W  F+     +  
Sbjct: 7755 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 7794

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698
            WL   E ++ Q      + DI   E+  K  K+ Q+ +   +   + +        +A  
Sbjct: 7795 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7848

Query: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
              ++ +++ +L ++N RW  +  L+      L++ L+  Q   +    L   L +I+   
Sbjct: 7849 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7908

Query: 759  NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807
             + +  DS  ++E +Q    +  +++ ++ +    VAS+ ++ C++L++
Sbjct: 7909 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 7955



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 129/808 (15%), Positives = 321/808 (39%), Gaps = 88/808 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            ++++    +  + +H  ++       LK+      Q++K ++ + TW   +E  L     
Sbjct: 2273 DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLM---- 2328

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
              +C   E    L + +++Q++++   + ++S       L     +    AE +S+ +A 
Sbjct: 2329 --NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESLGRAM 2382

Query: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
              L ++   +  +  + +  ++E+  L + F +    F++W   ++  A   S       
Sbjct: 2383 TGLIKKHEAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSK 2440

Query: 196  VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 255
            V + +L   +     V +  ++L+ + ++ + L          S+++ + + N+ +    
Sbjct: 2441 VLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFL 2500

Query: 256  KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-----DVQAKIKQ 310
            K+     + L+    +   FE     + +W+ EM+ +  N E+  E      + + ++ +
Sbjct: 2501 KQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME-ERFNTENLGESKQHIPEKKNEVHK 2559

Query: 311  LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
            ++ F  E+      ++++  +G+ L E+              +  R C ++       H+
Sbjct: 2560 VEMFLGELLAARESLDKLSQRGQLLSEEG---------HGAGQEGRLCSQLL----TSHQ 2606

Query: 371  KLIRLPLPDDEHDLSDRELELEDSAALSDL-----HWHDRSADSLLSPQPSSNLSLSLAQ 425
             L+R+     +  L   ++ L++  AL +       W     D L   + +     +L +
Sbjct: 2607 NLLRM----TKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662

Query: 426  PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVG 485
             L   +         D + ++ + +  L+  +     +AL S ++EGQ      L     
Sbjct: 2663 RLSQIQ---------DILLMKGEGEVKLNMAIGKG-EQALRSSNKEGQRVIQTQLETLKE 2712

Query: 486  L-SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544
            + +D+M   S   + + T  ++ +   D+   ++Q+ Q  +++D      Q+ E+ ++ +
Sbjct: 2713 VWADIM---SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD------QKIEHPLQPQ 2763

Query: 545  TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGV 602
             P   E          +L E      ++ RL  K +E  E+     F +    E +T   
Sbjct: 2764 -PGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKT--- 2819

Query: 603  IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
              ++  +   A  K  ++++ ++    +   ++    WL   +EEL +    ++S D   
Sbjct: 2820 --QFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS--DMSGDSSA 2875

Query: 663  IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMNGRWDRVCS 721
             + ++ K+KEL  + +   + +  +   +PE  Q  +    +L    +  +   W +   
Sbjct: 2876 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2935

Query: 722  LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---------DSNLDAEI 772
             + + +  L++ + Q     +   G +  LE    + + ++             N D EI
Sbjct: 2936 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 2995

Query: 773  LQDHHK--------QLMQIKHELLESQL 792
            ++  HK        Q  + + E L+SQL
Sbjct: 2996 VECWHKGQEILDALQKAEPRTEDLKSQL 3023



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)

Query: 15   SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71
            S++E +L ++ + W    + ++  + +L+  L    +     + L  WL   +  L    
Sbjct: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +  V      E ++  LN   E  ++++  S+  +SVL+    LL          +  ++
Sbjct: 6823 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 6877

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190
            +     +D +W ++       + K+ +            S    W+   E        + 
Sbjct: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937

Query: 191  --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241
               + Y    E L+K++ F+  ++     ++ +N+   +++       R ++TD A  L 
Sbjct: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300
             M    N+ W  LQ  VT  ++ L+  +    E+E     +  W    + +L        
Sbjct: 6998 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 7053

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            +  VQ  +K  +  +  I     ++E+I   G  LI+  +   ++I+   L EL +    
Sbjct: 7054 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 7113

Query: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
            +                   +H +   ++ L+  + L     H  + D + S    +  S
Sbjct: 7114 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 7152

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
            LS  + L           S++++ ++ D+  +L  DLE                 ++  L
Sbjct: 7153 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 7187

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529
            +    +++ ++ E      +   N +K  +   + L  +I    Q  KAL        D 
Sbjct: 7188 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 7247

Query: 530  SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
            S+     +QQ E+      K  T  ++ D     +++   +    + +VK     L E  
Sbjct: 7248 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 7307

Query: 584  ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640
            E L   V+  +     +  +   + L A  QAL K +  ++  +  ++ F   L ++ AW
Sbjct: 7308 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 7367

Query: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
            + + EE L Q Q    S+D+ TI+ ++++L          K  +L  +  +P+  + +  
Sbjct: 7368 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 7416

Query: 701  ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
              R  L D    R+  +N  W  + S   E    LQ  L+Q Q F          LE  +
Sbjct: 7417 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 7466

Query: 756  RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792
                 +V  +  L  EI  ++   L Q + HEL ++++
Sbjct: 7467 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 7504



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 149/812 (18%), Positives = 306/812 (37%), Gaps = 114/812 (14%)

Query: 18   EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 77
            + +L  + +R++ + +     V K ++ +   Q+  +++ +   WL   + +L +  V +
Sbjct: 3463 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3522

Query: 78   SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 137
              ++   +  L + QELQ    +    + SVL+  E ++      A D   +S++Q    
Sbjct: 3523 G-DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD--- 3578

Query: 138  LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 197
                W+       E R +        +     + + ++WLK++E   + P +        
Sbjct: 3579 ----WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS-PRTRRQSNRAT 3633

Query: 198  KE-ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNL 254
            KE +L + + +  +V     ++E +  + + +  E+  +S   C   Q+      R+  L
Sbjct: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT----SRYQAL 3689

Query: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQ 310
              +V   ++ L+  I   EE E++  S   W         N    I+      +  K+K 
Sbjct: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749

Query: 311  LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
            L+   +++   H+ ++    +GE+ ++  E  +A  + +E+ +     +E+   V + H 
Sbjct: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHM 3809

Query: 371  KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430
             L +      E     + L    +     LH  +     L   +   +   SL Q + S 
Sbjct: 3810 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3869

Query: 431  RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 490
                    SV S+  + +   +L +D        +  +D+  Q   D+    ++G   V 
Sbjct: 3870 E------PSVKSVREKGEALLELVQD--------VTLKDKIDQLQSDYQDLCSIGKEHVF 3915

Query: 491  IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 550
               S EA VK           DH    S+++++ K L     ++   + +  S   T  +
Sbjct: 3916 ---SLEAKVK-----------DHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961

Query: 551  LDTSYKGYMK------------------LLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
                +K  M+                  L+G+C+        L+ KLK+         N+
Sbjct: 3962 QLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCAD------HLQAKLKQ---------NV 4006

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
            H+      G  D +  + + A      ++  LQK       L    AWL   + +LE   
Sbjct: 4007 HA---HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSP 4063

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ- 711
            +  LS   + I+ Q+K  + LQ+       ++ S+   S    +  +K+ +  +  + Q 
Sbjct: 4064 QPPLSR-AEAIK-QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4121

Query: 712  ------MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 765
                  +   W+ +  L  E    LQDA  Q              L+N+ RR +E     
Sbjct: 4122 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQ--------------LQNMKRRHSE----- 4162

Query: 766  SNLDAEILQDHHKQLMQIKHELLESQLRVASL 797
              L+  I Q+   Q+     +L   Q  V ++
Sbjct: 4163 --LELNIAQNMVSQVKDFVKKLQSKQASVNTI 4192



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+RL +        E   KL  ++++WQ ++     R   +   +   Q+  +    LR 
Sbjct: 7518 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 7577

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            WL  +       +       ++ +   +E Q  ++   +        +   + LL   D+
Sbjct: 7578 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 7637

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
             A  A    +Q     +  +W++      E++ K+    + W+K     +   + L++ +
Sbjct: 7638 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693

Query: 182  R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +  + + P     ++   +   K+ E       + LTQL L+      L+     D    
Sbjct: 7694 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 7749

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
            L + V    ++W+ L  +++   +++   + +   F      +  WLT+M+   + +   
Sbjct: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 7806

Query: 300  SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
             +  ++  I++LK  +Q+EI++      Q+   GE+L + S    A+ IE +L ++    
Sbjct: 7807 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
            Q +   +    KKL                   E   A+  L   D++  SL +    ++
Sbjct: 7867 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 7903

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476
            +   LA+P+  +        + + I  + +   +L RD+E  S    ++ +  E    D 
Sbjct: 7904 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 7957

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533
            D     A   S   I ++     +   N    +      +E   R   K LDD SRF+  
Sbjct: 7958 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 8014

Query: 534  IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587
            ++ +E      + +G       E    ++ + + + EC + ++ + +   +L  E  +  
Sbjct: 8015 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 8072

Query: 588  GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647
               +  S +        RW+ LQ +  S   R+K  + + ++F +  +SI  WL + + +
Sbjct: 8073 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 8130

Query: 648  LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681
            L  ++      D+Q    +IK+LK  Q+  +++H K
Sbjct: 8131 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 8162



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 163/931 (17%), Positives = 353/931 (37%), Gaps = 144/931 (15%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            ++E K+  +  R Q +     A+V  L+          K    +   +   E +L++  +
Sbjct: 5070 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
              + +S E + KL+E + L   +      + ++    E      +    DA   ++ ++ 
Sbjct: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL----EEKASQLEKTGNDASKATLSRSM 5185

Query: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
              + +RW  + A++ ++   +E+    W  F +   +  + +   +      S+      
Sbjct: 5186 TTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKA 5245

Query: 196  VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS---LKQMVHEGNQRWD 252
                 L+  + F  ++ +  + L ++ +Q   + ++    +      L Q +     R  
Sbjct: 5246 ELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305

Query: 253  NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK 312
            N+Q++V +  + +K  +  RE  ET  +S+  W+ E    L N       ++ A++++L+
Sbjct: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN----PTIEIDAQLEELQ 5361

Query: 313  AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
                E + +   IE++                                     E   +K 
Sbjct: 5362 ILLTEATNHRQNIEKM------------------------------------AEEQKEKY 5385

Query: 373  IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 432
            + L      + +   EL L+ +    DL   D+  D +   + S   S  L++ ++    
Sbjct: 5386 LGL------YTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQK--- 5436

Query: 433  GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIP 492
                                L++DL + +++     D   Q   D           V+  
Sbjct: 5437 --------------------LAKDLTTILTKLKAKTDNVVQAKTD---------QKVLGE 5467

Query: 493  ESPEAYVKLTE--NAIKNTSGDHSALESQI-RQLGKALDDSRFQIQQTENIIRSKTPTGP 549
            E      KL E   A++     +  L   + +++GK  +  +  I+Q EN +        
Sbjct: 5468 ELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAAS 5527

Query: 550  ELDTSYKGYMKLLGECSSSIDSVKRLEHK--LKEEEESLPGFVNLHSTETQTAGVIDRWE 607
             L+     Y ++L      I+  K L H          L     LH T  + +  ID   
Sbjct: 5528 HLEE----YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS-- 5581

Query: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
              + +A++++L+   ++   ++ +  +    A LG   EEL Q+ ++ L  ++Q     +
Sbjct: 5582 --ELEAMTEKLQYLTSVYCTEKMSQQV----AELGRETEELRQMIKIRLQ-NLQDAAKDM 5634

Query: 668  KK----LKELQKAVDHRKAIILSINLCSPEFTQADSKES-RDLQDRLSQMNGRWDRV--C 720
            KK    LK+LQ A++  +A      L SPE  +   KE     Q  LS+M     +V   
Sbjct: 5635 KKFEAELKKLQAALEQAQA-----TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 5689

Query: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ------ 774
             L +    + +D +        + H  L + E   R ++  +   + + A ++Q      
Sbjct: 5690 QLCQSALRIPEDVVASL----PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5745

Query: 775  --DHHKQLMQIKH-ELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLL 830
               H +QL++  H E+ +  +  +++Q++  Q+  + E    ++  +E++  + ++ K+L
Sbjct: 5746 EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKML 5805

Query: 831  LKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSL 890
              + ++H   L  + +V    +           D  G + PT   + P+      G+C  
Sbjct: 5806 TMK-AKHATMLLTVTEVEGLAEGTE--------DLDGELLPTPS-AHPSVVMMTAGRCH- 5854

Query: 891  SQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS 921
                  +S     S + G++S +S P   RS
Sbjct: 5855 ----TLLSPVTEESGEEGTNSEISSPPACRS 5881



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 181/887 (20%), Positives = 351/887 (39%), Gaps = 150/887 (16%)

Query: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
            L + S E++A +   +L K++  ++ L+ L++   K L      VQ  +   +SL   ++
Sbjct: 1191 LTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELIS 1250

Query: 65   ---HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
                ++ +  K  + D+ N  E Q+ L   Q+  + I      V   +   +      + 
Sbjct: 1251 GSKEVQEQAEK--ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQ----QGEG 1304

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL---- 177
               D   + +++    LD   R+      ERR+++  T R W++F  +      +L    
Sbjct: 1305 GLPDRGHEELRKLESTLDGLERS--RERQERRIQV--TLRKWERFETNKETVVRYLFQTG 1360

Query: 178  KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR--LARENRT- 234
             S ER  +F S   +       EL++ + F ++      Q E + K+     L  +N+  
Sbjct: 1361 SSHERFLSFSSLESL-----SSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL 1415

Query: 235  --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
                A S+K+ V +     +   K +  +  +  HF      FET    + VW+TE + +
Sbjct: 1416 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHF---GSNFET----LSVWITEKEKE 1468

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352
            L  +E  S   +  +I Q+K   QEI    + I  +  + +   +     ++A I+ +L 
Sbjct: 1469 LNALETSSSA-MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527

Query: 353  ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412
            ++RRY +E+     R H + +                   +   L  L    +  ++L  
Sbjct: 1528 QIRRYGEEL-----REHAQCL-------------------EGTILGHLSQQQKFEENLRK 1563

Query: 413  PQPS-SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
             Q S S     LA P++   S  +T   +           DL + LES +S A+ +    
Sbjct: 1564 IQQSVSEFEDKLAVPIKICSSATETYKVL-------QEHMDLCQALES-LSSAITAFSAS 1615

Query: 472  GQD--DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI---RQLGKA 526
             +   ++D  ++ A  L             +  E+ ++      +ALE+ +   ++L K 
Sbjct: 1616 ARKVVNRDSCVQEAAALQ------------QQYEDILRRAKERQTALENLLAHWQRLEKE 1663

Query: 527  LDDSRFQIQQTENIIRSKTPTGPELDTS-----YKGYMKLLGECSSSIDSVKRLEHKLKE 581
            L      +++ E        + PE+D S      +G ++L+    + + S      KL +
Sbjct: 1664 LSSFLTWLERGE-----AKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQ 1718

Query: 582  EEESLPGFV---NLHSTETQTAGVIDRWELLQAQALSKELRMKQN-LQKWQQFNSDLNSI 637
             +ESL       ++   +     + +RW  L  Q ++K +   Q+ + + QQF+  L S 
Sbjct: 1719 LKESLFSVASKDDVKMMKLHLEQLDERWRDL-PQIINKRINFLQSVVAEHQQFDELLLSF 1777

Query: 638  WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 697
              W+         L  L+ +++I  ++ Q+     L +  DH   +            ++
Sbjct: 1778 SVWI------KLFLSELQTTSEISIMDHQV----ALTRHKDHAAEV------------ES 1815

Query: 698  DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC-QGFHEMSHGLLLMLENIDR 756
               E + LQ  L+++ G   R   L      LLQ     C Q F E S       + ++R
Sbjct: 1816 KKGELQSLQGHLAKL-GSLGRAEDL-----HLLQGKAEDCFQLFEEAS-------QVVER 1862

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
            R+  +  +     AE LQ  H  L  I  +L ++     S+       L+  +  D L+ 
Sbjct: 1863 RQLALSHL-----AEFLQS-HASLSGILRQLRQTVEATNSMNKNESD-LIEKDLNDALQN 1915

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
             + +      L  +L +   H+K       + SS+Q  S  ++AD+L
Sbjct: 1916 AKALESAAVSLDGILSKAQYHLK-------IGSSEQRTSCRATADQL 1955



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 142/799 (17%), Positives = 312/799 (39%), Gaps = 95/799 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            +L K+ D +  L+ +I +R   L + L    Q ++ +  L   L   + ++A        
Sbjct: 6559 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 6618

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            + EEIQ+ L++ +E  + +E H       + L E L     + A   E     Q    L 
Sbjct: 6619 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 6667

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             +   +   + +R +++E     W   LD     ED  + S +     SS   +  V + 
Sbjct: 6668 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 6721

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256
            E +  +      H   +  E   K Y+ L    R   + S   L+  +++  + W +   
Sbjct: 6722 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6781

Query: 257  RVTSILRR----LKHFIGQREE-------FETARDSILVWLTEMDLQLTNIEHFSECDVQ 305
            +++  L R    LKH+   + E        ++A+D +  W  +       +E      V+
Sbjct: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEM-----VR 6836

Query: 306  AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 365
              +     F +E+    +    +++ G QL+ + + +D A +  EL  +     ++   +
Sbjct: 6837 DHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNI 6895

Query: 366  ERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQ 425
                +KL +L +            +L    A+S++       ++++  +   N+  S+  
Sbjct: 6896 PAVQEKLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGY 6943

Query: 426  PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-G 482
                E   +     +D       +   L+ D  +     + S+D E +  D  DF  + G
Sbjct: 6944 KAIHEYLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997

Query: 483  AVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
            A+  S  ++       ++L E  +++     S  E+ ++ L    +    +++Q   I  
Sbjct: 6998 AMNKSWQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI-- 7051

Query: 543  SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 602
                               L +C    D +K  E ++++ E++  G   + + +   + +
Sbjct: 7052 ----------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSI 7099

Query: 603  I--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL 654
            +          W  L       ++ +K  L +W       + I ++L +    L + +  
Sbjct: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL- 7158

Query: 655  ELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMN 713
             L+  ++ +++Q+  L+ LQ  ++ ++  +    ++ +    +     +  L + L ++N
Sbjct: 7159 -LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVN 7217

Query: 714  GRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA 770
             RW+   +LLEE    LQ   AL+Q  Q + + S      ++  + R NE++   +N D 
Sbjct: 7218 MRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD- 7273

Query: 771  EILQDHHKQLMQIKHELLE 789
             I  D     +Q  ++LL+
Sbjct: 7274 -IADDEVATWIQDCNDLLK 7291



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 171/974 (17%), Positives = 361/974 (37%), Gaps = 120/974 (12%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L+    + KA  I+ K+    + W++    +  +   L+   + ++  + +   ++ 
Sbjct: 3128 GELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQD 3187

Query: 62   WLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            WL+  E      +V++S N   ++  K  EQQ+LQ  +E+       +  L E      +
Sbjct: 3188 WLSKTEK-----MVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3242

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
                 A   S +     L  ++  +  ++ E+  +++       +F       +DW+  +
Sbjct: 3243 G---QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3299

Query: 181  ER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
                 +   P+S     +V      K EA      E   Q+++I  +   + +    +  
Sbjct: 3300 IHMLDSYCHPTSD---KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3356

Query: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
             +++Q +      W +L         +L+  + +   ++        W+  M+  L   E
Sbjct: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416

Query: 298  --HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
              H    D    + + K   +E+    + +E I  +G  +   +E     +  ++L E  
Sbjct: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM---TEHYVTQLELQDLQERY 3473

Query: 356  RYCQEVFGRVERYHKKLIRL------PLPDDEHDLSDRELELEDSAAL-SDLHWHDRSAD 408
            R  QE         +KL+RL       L   E  L   + +L+  + L  D H H+ +  
Sbjct: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3533

Query: 409  SLLSPQPSSNLSLSLAQPLRSERSG-------RDTPASVDSIPLEW---DHDYDLSRDLE 458
             L   Q       +L   +   R         +    +++S+  +W    H    +R   
Sbjct: 3534 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
            + +   L   +++ Q   ++       +S     +S  A  ++  + +K    + +A   
Sbjct: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653

Query: 519  QIRQLG----KALDDSR--------------------FQIQQTENIIRSKTPTGPELDTS 554
            ++ ++G    + LD+S                      Q+ +    +  +  +  E ++S
Sbjct: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713

Query: 555  YKGYMKLLG-------ECSSSIDSV---------KRLEHKLKEEEESLPGFVNLHSTETQ 598
               Y    G         ++ ID V         K LE  LK+ E+   G   L S   +
Sbjct: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEK---GHSLLKSAREK 3770

Query: 599  TAGVIDRWELLQAQALSKELR-------------------MKQNLQKWQQFNSDLNSIWA 639
                +   E  +A+ L KE+                    +++ L   ++F+    ++  
Sbjct: 3771 GERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ 3830

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699
            W+ + +E L   +  E   ++   + Q+ K K LQ+ V   +  + S+        +   
Sbjct: 3831 WIAEYQEILHVPE--EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-- 3886

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-EMSHGLLLMLENIDRRK 758
             +   L+D++ Q+   +  +CS+ +E    L+  +   + ++ E+      +L+   R  
Sbjct: 3887 VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946

Query: 759  NEIVPIDSNLDAEILQ-DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 817
               +   S+L+    Q  HHK +M+   E+   + R+ +LQ     L+   +  D L+AK
Sbjct: 3947 APDLLETSSLETITQQLAHHKAMME---EIAGFEDRLNNLQMKGDTLI--GQCADHLQAK 4001

Query: 818  EK----VHVIGNR--LKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELDTSG 867
             K     H+ G +     +     R  + LE  L    S+QD      +W SA + D   
Sbjct: 4002 LKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEP 4061

Query: 868  SVSPTSGRSTPNRQ 881
            S  P   R+   +Q
Sbjct: 4062 SPQPPLSRAEAIKQ 4075



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 114/604 (18%), Positives = 241/604 (39%), Gaps = 106/604 (17%)

Query: 303  DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
            DV  ++K  K+ Q  +    N++  + AQG +L+++    + + +  +L EL+     V 
Sbjct: 4488 DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL 4547

Query: 363  G----RVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL---------SDLHWHDRSADS 409
                 R++   K L+      ++ D +   L+  D             S+LH       +
Sbjct: 4548 QKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQN 4607

Query: 410  LLSPQPS-SNLSLSLAQ------PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMS 462
            +L   P   NL L+L +      P  +E         ++++P +++    L++D    + 
Sbjct: 4608 ILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQ 4667

Query: 463  RALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT--------ENAIKNTSGDHS 514
             A+ +  E             + L+   + E    +++++        E A+    G  +
Sbjct: 4668 EAILARKEYAS---------LIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRA 4718

Query: 515  ALESQIRQLGKALDD---------SRFQIQQTENII-------RSKTPTGPELD------ 552
             L+ ++  LG+A+D+         S  Q  Q + ++       R K  T   +       
Sbjct: 4719 ILD-EVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTT 4777

Query: 553  TSYKGYMKLLGECSSSIDSVKRLEHKLKEE----EESLPGFVNLHSTETQTAGVIDRWEL 608
            ++Y+ + K+  +    + SVK  + K+ EE    EE L  + +L  +  Q +G++ +   
Sbjct: 4778 SAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGS-LQDSGIVLKRVT 4836

Query: 609  LQAQALSKEL------RMKQNLQKWQ-------------------------QFNSDLNSI 637
            +  + L+  L      + +  +Q WQ                          F ++++  
Sbjct: 4837 IHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRS 4896

Query: 638  WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE-FTQ 696
              WL   + EL     L+L+  +Q I+ +I+K++  Q+ V     I+ +++    E FT+
Sbjct: 4897 LDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK 4954

Query: 697  ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
            A    S DL+  L++++     +   L   +  L +   QCQ ++++       LE+   
Sbjct: 4955 AKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--- 5011

Query: 757  RKNEIVPIDSN-LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL--LVNAEGTDC 813
               E++ +  N LD E  +++ K  M+      +    +  L  +   L  L+   G + 
Sbjct: 5012 -AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED 5070

Query: 814  LEAK 817
            LE K
Sbjct: 5071 LEQK 5074



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)

Query: 527  LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
            LD+ + ++ +   ++ S  P+     E +      + L     SS++  +   +++ ++ 
Sbjct: 6694 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 6753

Query: 584  ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642
            + L   ++    E+Q   + + W L     +SKEL R++  L+ W ++ S+   +  WL 
Sbjct: 6754 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6812

Query: 643  DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
              ++ LE    Q + +  +++ +   +    E  K VD + ++  S+     +  +    
Sbjct: 6813 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6872

Query: 701  ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
            ++  L+  LS+++ +W      + ++ E+   L  D L       E+   + LM EN+ +
Sbjct: 6873 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 6931

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813
            +  +   I +++  + + ++ ++    K ++   QL V  +     Q+    V ++ +D 
Sbjct: 6932 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989

Query: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862
             +  E++  +    ++L   V+  I+ LE LL    +  ++ Q L +W    E
Sbjct: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 7042



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
            S  S  ++   +LG +N  WQ L  L+  +++ L+  L +  + + N+  L+TW    E 
Sbjct: 6984 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043

Query: 69   ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120
             L +   +   +   +Q  L + Q+L       ++++EK    G+A + N  E       
Sbjct: 7044 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 7094

Query: 121  ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
                  +  SI  +T R L + W N+  M  + ++ ++     W      + +   +L  
Sbjct: 7095 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7148

Query: 180  SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
            +  + + F   +G +  V + ++   +  Q  + +    L+       +L +E       
Sbjct: 7149 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7207

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLK 266
            +L   + E N RW+NL + +   L+  K
Sbjct: 7208 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 7235



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76
            KLG +   W+ L ++I+ + + L E L   Q+   ++ S+ T +  IE   SE  +P   
Sbjct: 5936 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 5995

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                  E Q  ++E   LQ +I +  + +A      E++   C+  A  AE  ++Q    
Sbjct: 5996 PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 6048

Query: 137  NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183
             L  R   I   +  +R  +EE            +  Q++  +    + WL S++    T
Sbjct: 6049 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6108

Query: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
            A  P    +       + +       Q    L++L + N+      + +  D A  L   
Sbjct: 6109 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6168

Query: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298
            +         LQ+ +      ++    ++EE +     T    +  WL +     T    
Sbjct: 6169 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 6225

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350
                  Q+ ++Q K  +QE++   + +  + ++GE+++ +    + +        ++ +E
Sbjct: 6226 ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 6281

Query: 351  L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398
            L          D++R   + +        K L  +   + E  L  R   L     L   
Sbjct: 6282 LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 6341

Query: 399  DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451
            D+   D+SA  SLL        + SS    +  Q +  E+   D  ++  +    W  D 
Sbjct: 6342 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 6397

Query: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501
            +    + +A+   LP E E    +++   +    +S+ M           PE+ +    +
Sbjct: 6398 EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 6453

Query: 502  TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
             E+ +    G  S L+S + Q    + +   QI   +N +  K       D  Y    KL
Sbjct: 6454 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 6511

Query: 562  LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607
                    +  I+++++ E  LKE +    G + L            +  + + + D ++
Sbjct: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568

Query: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
             L     S+   + QNL    Q+   L  +   L   +E++   Q++ +S+  +  +L  
Sbjct: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 6628

Query: 668  KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721
            K  +  Q    H   +IL+  L     + A  KE++   + ++Q +    R         
Sbjct: 6629 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6685

Query: 722  -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
             +LE W  L +D         E+S      LE ++     +  ++ N D   L D     
Sbjct: 6686 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 6732

Query: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
              +K  L E Q ++  + D   +LL++     C + + +++ +G        ++S+ +  
Sbjct: 6733 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 6789

Query: 841  LEKLLD----VSSSQQDLSSW--SSADELD 864
            LE +L       S   DL  W  S+ D L+
Sbjct: 6790 LETILKHWTRYQSESADLIHWLQSAKDRLE 6819



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 141/728 (19%), Positives = 273/728 (37%), Gaps = 177/728 (24%)

Query: 249  QRWDNLQKRVTSIL----RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SEC 302
            Q W    K +TS +       +  + Q  +F+T     L WL  +  +L+   +   +  
Sbjct: 4859 QSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQ 4918

Query: 303  DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY----- 357
            D+Q +I++++  Q+E+  +   +  +  + ++   K++ L +A +E  L EL        
Sbjct: 4919 DIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQ 4978

Query: 358  ---------CQEVFGRVERYHKKLIR-----------LPLPDDEHDLSDRELELEDS--- 394
                       E++ + +RY++               L L  +  D+   E  L+     
Sbjct: 4979 EALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF 5038

Query: 395  --------AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ-PLRSERSGRDTPASVDSI-- 443
                    + L +LH    + D L+ P    +L   +A   LRS+R  RD+ A VD +  
Sbjct: 5039 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5098

Query: 444  -PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
               +W HDY  +R+           E  E  +D +  L      S +    S EA  KL+
Sbjct: 5099 CTAQW-HDYQKARE-----------EVIELMNDTEKKLS---EFSLLKTSSSHEAEEKLS 5143

Query: 503  ENAIKNTSGDHSALESQIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 559
            E         H AL S +    +   AL++   Q+++T N   SK      + T ++ + 
Sbjct: 5144 E---------HKALVSVVNSFHEKIVALEEKASQLEKTGN-DASKATLSRSMTTVWQRWT 5193

Query: 560  KL--------------LGECSSSIDSVKRLEHKLKEEEESLPG-------------FVNL 592
            +L              + E +   + VK+    + + ++ LPG              +  
Sbjct: 5194 RLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEY 5253

Query: 593  HST---------------ETQTAGVI----------------------DRWELLQAQALS 615
            H T                 QT  ++                      DR   +Q +  +
Sbjct: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT 5313

Query: 616  KELRMKQNLQKWQQFNSDLNSIWAWLGDTEE-----------ELEQLQRL--ELSTDIQT 662
                +KQ L+  +   + +NS+  W+ +T+E           +LE+LQ L  E +   Q 
Sbjct: 5314 NGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5373

Query: 663  IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
            IE   ++ KE    +       LS+ L        D K    +QD++ +           
Sbjct: 5374 IEKMAEEQKEKYLGLYTILPSELSLQLAE---VALDLKIRDQIQDKIKE----------- 5419

Query: 723  LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
            +E+ +   Q+   Q Q   +++  L  +L  +  + + +V   +  D ++L +   +L  
Sbjct: 5420 VEQSKATSQELSRQIQ---KLAKDLTTILTKLKAKTDNVV--QAKTDQKVLGE---ELDG 5471

Query: 783  IKHELLESQLRVASLQDMSCQL---LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
               +L+E    V    + + QL   L    G      ++ +    NRL   L + + H++
Sbjct: 5472 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS-KLNQAASHLE 5530

Query: 840  ELEKLLDV 847
            E  ++L++
Sbjct: 5531 EYNEMLEL 5538



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 152/743 (20%), Positives = 287/743 (38%), Gaps = 100/743 (13%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            E L   + +     ++  L ++++RW+ L  +I  R+  L+  +   QQ D+ + S   W
Sbjct: 1721 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780

Query: 63   LAHIESELAK-----------PIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLN 110
            +    SEL              +     ++ E++ K  E Q LQ  + K  S G A  L+
Sbjct: 1781 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1840

Query: 111  LCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQK 165
            L +    DC     +A    +  Q A  +L    ++  ++S    + R  +E T  + + 
Sbjct: 1841 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1900

Query: 166  FLDDYSR-FEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 224
              D   +   D L++++   +   S   I + A+  LK   + QR    C    + +  +
Sbjct: 1901 ESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGE 1958

Query: 225  YRRL-----ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 279
              R+      +++  D+   LK+   +   + + L K +  I  R       +E    A 
Sbjct: 1959 VERIQNLLGTKQSEADALAVLKKAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQAL 2014

Query: 280  DSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQL 335
               L    +++ +L + EH   C ++ K KQ+     AF  E+    N++E      ++L
Sbjct: 2015 QQRLRVFNQLEDELNSHEH-ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2073

Query: 336  IEKSEPLDAAIIE--EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 393
            I +++     +I+   E   L+    +V   +E     ++      D+ DL  +    + 
Sbjct: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKV---LENASSVIVTRTTIKDQEDL--KWAFSKH 2128

Query: 394  SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 453
              A + +++  +  D+  S        L             D  ++VD    +W    D+
Sbjct: 2129 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD----KW---LDV 2181

Query: 454  SRDLESAMSR----------ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            S  LE  M R           L + DE      +   + A  +S++      E  +K  E
Sbjct: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFE 2241

Query: 504  NAIKNTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
            + +KN +     L S++   ++L K L+     +Q  E  +  K     E+    KG +K
Sbjct: 2242 SEVKNKALRLEELHSKVNDLKELTKNLETPP-DLQFIEADLMQKLEHAKEITEVAKGTLK 2300

Query: 561  LLGECSSSIDS-VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
                 S+ ++  +  +     + EESL   +N    ET              +AL K   
Sbjct: 2301 DFTAQSTQVEKFINDITTWFTKVEESL---MNCAQNET-------------CEALKKVKD 2344

Query: 620  MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 679
            +++ LQ  QQ N         +  T+E L  L R   S +++++   +  L +  +AV  
Sbjct: 2345 IQKELQS-QQSN---------ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS- 2393

Query: 680  RKAIILSINLCSPEFTQADSKES 702
                     LCS   TQA  +ES
Sbjct: 2394 --------QLCSK--TQASLQES 2406



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 157/826 (19%), Positives = 311/826 (37%), Gaps = 150/826 (18%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHL-----------LDLIAARVKK----LKET 45
            M  ++A   H+  A+E+E K G++     HL           L L+  + +      +E 
Sbjct: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856

Query: 46   LVAVQQLDKNMSSLRTW------LAHIESELAKPI-VYDSCNSEE---IQRKLNEQQELQ 95
               V++    +S L  +      L+ I  +L + +   +S N  E   I++ LN+  +  
Sbjct: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916

Query: 96   RDIEKHSTGVASVLNLCEVLLH--------DCDACATDAECDSIQQATRNLDRRWRNICA 147
            + +E  +  +  +L+  +  L          C A A D  C  +++    L  +     A
Sbjct: 1917 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATA-DQLCGEVERIQNLLGTKQSEADA 1975

Query: 148  MSM------------------------ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 183
            +++                        + RLK E T +  Q+ L  +++ ED L S E  
Sbjct: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHE 2034

Query: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
              +      +   AK+  +K  AF  +V   + +LE+     +RL  EN+    C L  +
Sbjct: 2035 LCW------LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ-GQCCGLIDL 2087

Query: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL--------TEMDLQLTN 295
            + E    + NL+  V+ +L      I  R   +   D  L W          +M+ +  +
Sbjct: 2088 MRE----YQNLKSAVSKVLENASSVIVTRTTIKDQED--LKWAFSKHETAKNKMNYKQKD 2141

Query: 296  IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
            +++F+        +  K    + SL    +E  + +   + EK        +EE +D LR
Sbjct: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK--------LEENMDRLR 2193

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 415
                             + L + DD   LS R+ E+E         W +        PQ 
Sbjct: 2194 -----------------VSLSIWDDV--LSTRD-EIEG--------WSNNCV-----PQM 2220

Query: 416  SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 475
            + N+S +L   LR+E   ++  + V +  L  +  +    DL+        +++ E   D
Sbjct: 2221 AENIS-NLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKEL------TKNLETPPD 2273

Query: 476  KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535
              F         +  + +  E   ++TE A K T  D +A  +Q+ +     D + +  +
Sbjct: 2274 LQFI--------EADLMQKLEHAKEITEVA-KGTLKDFTAQSTQVEKF--INDITTWFTK 2322

Query: 536  QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 595
              E+++        E     K   K L    S+I S +   + L  +  S      L S 
Sbjct: 2323 VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESL 2378

Query: 596  ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW-LGDTEEELEQLQRL 654
                 G+I + E +       +  ++++L+K   F+  +     W LG      E   R 
Sbjct: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDR- 2435

Query: 655  ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE-SRDLQDRLSQMN 713
              + D + +E ++  L+ +  +V   ++ + ++           SK+    +Q+++++ N
Sbjct: 2436 --TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2493

Query: 714  GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
              +        + +  LQD   +   F +    L L +  ++ R N
Sbjct: 2494 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2539



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/372 (21%), Positives = 159/372 (42%), Gaps = 52/372 (13%)

Query: 531  RFQIQQTENIIRSKTPTGP--ELDTSYKGYMKLLGECSSSIDSVKRLE-------HKLKE 581
            RF+  + E ++R    TG   E   S+     L  E   + +  KR E       + +KE
Sbjct: 1344 RFETNK-ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE 1402

Query: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ-KWQQFNSDLNSIWAW 640
              E   G  N    + Q   + ++ + L+   L ++++  + ++ KW  F S+  ++  W
Sbjct: 1403 ASEIPLGPQNKQLLQQQAKSIKEQVKKLE-DTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1461

Query: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADS 699
            + + E+EL  L+     T    +++QI ++K   + ++ + + I+ +   +  F Q   +
Sbjct: 1462 ITEKEKELNALE-----TSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT 1516

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
             ES  ++ +L+Q+    + +    +   G +   L Q Q F E    L  + +++   ++
Sbjct: 1517 GESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEE---NLRKIQQSVSEFED 1573

Query: 760  EI-VPIDSNLDA----EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEG---- 810
            ++ VPI     A    ++LQ+H         + LES     +    S + +VN +     
Sbjct: 1574 KLAVPIKICSSATETYKVLQEHMDLC-----QALESLSSAITAFSASARKVVNRDSCVQE 1628

Query: 811  --------TDCL-EAKEKVHVIGNRL---KLLLKEVSRHIKELEK-LLDVSSSQQDLSSW 857
                     D L  AKE+   + N L   + L KE+S  +  LE+     SS + D+   
Sbjct: 1629 AAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDI--- 1685

Query: 858  SSADELDTSGSV 869
             SAD +   G +
Sbjct: 1686 -SADRVKVEGEL 1696



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)

Query: 581 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 640
           EE E++  F+N    ET       +W  L  +  S    +++ +  W ++ + + S+ AW
Sbjct: 578 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 628

Query: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
           L D E+ L Q +  +               + L   +    A+  + N         D  
Sbjct: 629 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 674

Query: 701 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 760
            SRDL+ +L  +NGR          WR L  +     Q             + +DR K E
Sbjct: 675 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 712

Query: 761 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800
                  L A   + H K    ++   +  +L +  L+D+
Sbjct: 713 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 752



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            ++W+ +  +A  +   +   +++WQ++      +  WL        ++  L +S  + ++
Sbjct: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 7593

Query: 664  ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715
             + +++ + L   V  ++ +        IL++         ADS     LQ  L+++  +
Sbjct: 7594 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7653

Query: 716  WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
            W      LEE +  L   L   + + +   G+   LE +   K ++        ++ L D
Sbjct: 7654 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 7702

Query: 776  HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835
            HH++L   +    E +  V S  D   QL +  +      + + + ++  R++LL     
Sbjct: 7703 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 7758

Query: 836  RHIKELEKLLDVSSSQ--QDLSSWSSADE 862
            R  +EL   L +   Q  + L+ W+   E
Sbjct: 7759 RQWEELCHQLSLRRQQIGERLNEWAVFSE 7787



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)

Query: 606  WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
            W++LQ     K   ++  L+ W ++ +++  +  W    E+ L+Q  R+     +Q    
Sbjct: 7003 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 7062

Query: 666  QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725
              + L++L KA +     I    L   +  + D   S  +   L ++   W  +  ++ +
Sbjct: 7063 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 7120

Query: 726  WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             + LL+  L Q       F +++  L+    ++ R +     +  +L+A  +Q     L 
Sbjct: 7121 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 7174

Query: 782  QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841
             ++ +L + +  +     ++ QLL              +  +  R   LL+E++  ++  
Sbjct: 7175 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7234

Query: 842  EKLLDVSSSQQDLS 855
            + LL +    +D S
Sbjct: 7235 KALLQLWQRYKDYS 7248



 Score = 38.9 bits (89), Expect = 0.024
 Identities = 53/276 (19%), Positives = 120/276 (43%), Gaps = 25/276 (9%)

Query: 609  LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 668
            L+A   S   ++ ++  KW+ + S  +   +W+   E +L+ ++   + T       ++K
Sbjct: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDT---ANHGEVK 1164

Query: 669  K-LKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEW 726
            + ++E++  V  R   +  +       T+  S+ E++   D L++++  +  + +LL E 
Sbjct: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224

Query: 727  RGLLQDALMQCQGFHEMSHGLLLML----ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
              +L +    C  + E+    L  L    + +  +  +I+  ++  +A+ L  HH+Q  +
Sbjct: 1225 EKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTK 1283

Query: 783  --------IKHELLESQLRVASLQDMSCQLLVNAEGT-DCLEAKEKVHVIGNRLKLLLKE 833
                    ++ ++ ++Q     L D   + L   E T D LE   +      R+++ L++
Sbjct: 1284 RISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ--ERRIQVTLRK 1341

Query: 834  VSRHIKELEK----LLDVSSSQQDLSSWSSADELDT 865
              R     E     L    SS +   S+SS + L +
Sbjct: 1342 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSS 1377



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 39/328 (11%)

Query: 51  QLDKNM----SSLRTWLAHIESELAKPIVYDSCNSEE---IQRKLNEQQELQRDIEKHST 103
           QLDK++     ++  WL   E  L + I     + E    IQRKL + ++L ++ + H  
Sbjct: 402 QLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKR 461

Query: 104 GVASVLNLCEV--LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 161
               +     V  +    D     AE      +T  L         M ME    +E  +R
Sbjct: 462 AFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELH-------LMKMEF---LELKYR 511

Query: 162 LWQKFLDDYSRFEDWL-KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLEL 220
           L    +   S+ + W+ K   R +        +  +  E  K FE ++          E+
Sbjct: 512 LLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFI--ENSKFFEQYEVTYQILKQTAEM 569

Query: 221 INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARD 280
             K       +   + A ++ + ++E   +W NL   V S+   L+  I   + +     
Sbjct: 570 YVKA------DGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVA 623

Query: 281 SILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
           S+  WL + +  L   E+ ++ D    +      QQ  ++N          G  LIE  +
Sbjct: 624 SLQAWLEDAEKMLNQSEN-AKKDFFRNLPHW--IQQHTAMND--------AGNFLIETCD 672

Query: 341 PLDAAIIEEELDELRRYCQEVFGRVERY 368
            + +  ++++L  L    +E+F  V++Y
Sbjct: 673 EMVSRDLKQQLLLLNGRWRELFMEVKQY 700



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 143/730 (19%), Positives = 288/730 (39%), Gaps = 91/730 (12%)

Query: 38   RVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI--QRKLNEQQELQ 95
            RV  L++T  A Q+ +K    L   L  ++ E +K       N E +  + KL     L 
Sbjct: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSK------VNEETLPAEEKLKMYHSLA 4822

Query: 96   RDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLK 155
              ++     +  V    E L    D  A +     IQ     L      I     E   +
Sbjct: 4823 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4882

Query: 156  IEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 215
            + ++      F  + SR  DWL+  +   + P    +     +EE++K +  Q +V   L
Sbjct: 4883 MVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL 4938

Query: 216  TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 275
              +  ++ + +    + +   +  L+  + E ++   ++Q+ + +    L     Q + +
Sbjct: 4939 RIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998

Query: 276  ETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLN---HNKIEQ--- 327
                 +   WL +    LQL      +  DV++  + LK+  +  S     H+ +E+   
Sbjct: 4999 YQVFQAANDWLEDAQELLQLAG----NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHS 5054

Query: 328  IIAQGEQLIEKS--EPLDAAIIEEELD------------ELRRYCQEVFGRVERYHKKLI 373
            ++A  + LI+ +  E L+  +   EL             +L + C   +   ++  +++I
Sbjct: 5055 LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVI 5114

Query: 374  RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS--ER 431
             L + D E  LS+  L    S+  ++    +  A  L+S   S +  +   +   S  E+
Sbjct: 5115 EL-MNDTEKKLSEFSLLKTSSSHEAEEKLSEHKA--LVSVVNSFHEKIVALEEKASQLEK 5171

Query: 432  SGRDT-----PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
            +G D        S+ ++   W     +++D E  +  A+  ++  G ++K   ++ A  +
Sbjct: 5172 TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV--DEWTGFNNK---VKKATEM 5226

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGD-HSALESQIRQLGKALDDSRFQIQQTENIIR-SK 544
             D +  + P +  +    A   T  + H     ++ Q   AL   R   QQT ++++   
Sbjct: 5227 IDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR---QQTLSMLQDGA 5283

Query: 545  TPTGPELDTSYKGYMKLLGECSSSIDSVKR----LEHKLKEEE--ESLPGFVNLHSTETQ 598
             PT  E     +    +   C +  + VK     ++ +LK+ E  E+    V     ET+
Sbjct: 5284 APTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK 5343

Query: 599  ------TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                  T  +  + E LQ   L++    +QN++K  +   +      +LG     L  + 
Sbjct: 5344 EYLGNPTIEIDAQLEELQI-LLTEATNHRQNIEKMAEEQKE-----KYLG-----LYTIL 5392

Query: 653  RLELSTDIQTIELQIKKLKELQ---KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRL 709
              ELS  +  + L +K   ++Q   K V+  KA        S E ++   K ++DL   L
Sbjct: 5393 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKA-------TSQELSRQIQKLAKDLTTIL 5445

Query: 710  SQMNGRWDRV 719
            +++  + D V
Sbjct: 5446 TKLKAKTDNV 5455



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 59/369 (15%), Positives = 151/369 (40%), Gaps = 43/369 (11%)

Query: 13  KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
           +A  +   + +   +W++L   + +    L+E +    +    ++SL+ WL         
Sbjct: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWL--------- 629

Query: 73  PIVYDSCNSEEIQRKLNEQQELQRD--------IEKHSTGVASVLNLCEVLLHDCDACAT 124
                    E+ ++ LN+ +  ++D        I++H+    ++ +    L+  CD   +
Sbjct: 630 ---------EDAEKMLNQSENAKKDFFRNLPHWIQQHT----AMNDAGNFLIETCDEMVS 676

Query: 125 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
                 ++Q    L+ RWR +  M +++  + +E  R+ +++ D       +   + +  
Sbjct: 677 ----RDLKQQLLLLNGRWREL-FMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKL 731

Query: 185 AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV 244
           + P    V +   K  ++  E  +++V     Q ++I K    + +E+  +    +   +
Sbjct: 732 SEPLE--VSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789

Query: 245 HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDV 304
            +  ++   +++  + +L   +  +   EE E    S    L +++  +T +E  ++   
Sbjct: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849

Query: 305 --QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
             + K ++L A Q+    N  K   +I +G Q ++K   L   +   +   L+R   ++ 
Sbjct: 850 LFKQKHQELLACQE----NCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 905

Query: 363 GRVERYHKK 371
              +   KK
Sbjct: 906 VAFQSMVKK 914



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)

Query: 3    ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            +RL +  +    ++ E K +  +N  W  +      R  KL+  L+  Q   +   +   
Sbjct: 7411 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 7470

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            +L   E +LA  I   S N + +  +    +  Q ++      + S++   + LL     
Sbjct: 7471 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 7527

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179
                 + D        L  +W+ +   + +RR  I+   R WQ++ +   +   WL    
Sbjct: 7528 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 7583

Query: 180  ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
                    + P       T+  E   K + F RQ    +  +E      ++L     + +
Sbjct: 7584 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 7639

Query: 237  ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
              +L+  + E  ++W +   R+    ++L   +   E+ E      L  L     +L+  
Sbjct: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699

Query: 297  EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                  ++ A+  + K  +  +    + + Q+    + L       D +I+ E ++ L+R
Sbjct: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759

Query: 357  YCQEV 361
              +E+
Sbjct: 7760 QWEEL 7764



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 139/775 (17%), Positives = 298/775 (38%), Gaps = 106/775 (13%)

Query: 13   KASEIEYKLGKVNDRW-QHLLDLIAARVKKLKETL---VAVQQLDK--------NMSSLR 60
            +ASEI   LG  N +  Q     I  +VKKL++TL   +   ++ K        N  +L 
Sbjct: 1402 EASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1459

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
             W+   E EL       S    +I +     QE++  +     G+          +   +
Sbjct: 1460 VWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS-IVGLEEEAQSFAQFVTTGE 1518

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAM---SMERRLKIEETWRLWQKFLDDYSRFEDWL 177
            +    A+   I++    L    + +       + ++ K EE  R   K     S FED L
Sbjct: 1519 SARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLR---KIQQSVSEFEDKL 1575

Query: 178  KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
                +     SS+   Y V +E +   +A +  +   +T      ++   + R++    A
Sbjct: 1576 AVPIKIC---SSATETYKVLQEHMDLCQALE-SLSSAITAFSASARKV--VNRDSCVQEA 1629

Query: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
             +L+Q       +++++ +R       L++ +   +  E    S L WL   + + ++ E
Sbjct: 1630 AALQQ-------QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1682

Query: 298  HFSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---EEL 351
                 D   V+ +++ ++A Q E+    +   +++   E L   +   D  +++   E+L
Sbjct: 1683 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1742

Query: 352  DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL 411
            DE  R   ++  +   + + ++       EH   D  L       LS   W       L 
Sbjct: 1743 DERWRDLPQIINKRINFLQSVVA------EHQQFDELL-------LSFSVWIKLFLSEL- 1788

Query: 412  SPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
              Q +S +S+   Q   +    +D  A V+S             +L+S     L      
Sbjct: 1789 --QTTSEISIMDHQVALTRH--KDHAAEVES----------KKGELQSLQGH-LAKLGSL 1833

Query: 472  GQDDKDFYLRGAVGLSDVMIPESPEAYVK--LTENAIKNTSGDHSALESQIRQLGKALDD 529
            G+ +    L+G       +  E+ +   +  L  + +      H++L   +RQL + ++ 
Sbjct: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1893

Query: 530  SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV-KRLEHKLKEEEESLPG 588
            +    +   ++I        +L+ + +   K L   + S+D +  + ++ LK        
Sbjct: 1894 TNSMNKNESDLIEK------DLNDALQN-AKALESAAVSLDGILSKAQYHLK-------- 1938

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW--AWLGDTEE 646
               + S+E +T+          A  L  E+   QNL   +Q  +D  ++   A+    EE
Sbjct: 1939 ---IGSSEQRTSC------RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEE 1989

Query: 647  ELEQLQRLELSTDI--------QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
             L+ ++ +E  TD         Q ++ +++   +L+  ++  +  +  +   + +  Q D
Sbjct: 1990 LLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2049

Query: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 753
               + ++   ++++   WD    L+ E +G     +   + +  +   +  +LEN
Sbjct: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN 2104



 Score = 35.4 bits (80), Expect = 0.26
 Identities = 53/282 (18%), Positives = 123/282 (43%), Gaps = 29/282 (10%)

Query: 596  ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 655
            +TQ   + + W  + + ++  +  ++  + +W  +    N +  W+   ++++E    L+
Sbjct: 2704 QTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQ 2761

Query: 656  LSTDIQTIELQIKKLKE-LQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQM 712
                ++   + +  L+  L +A DH +A+  +++ +    E T+ +S +    ++  +Q 
Sbjct: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQF 2821

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            N         + +   +++D LM     HE +  L    E + R        D + D+  
Sbjct: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS------DMSGDSSA 2875

Query: 773  LQDHHKQLMQIKHELLESQ----LRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
             Q   K+L +IK EL++S+     R++ ++ ++ ++  N   + C    E +H     L+
Sbjct: 2876 TQ---KKLSKIK-ELIDSREIGASRLSRVESLAPEVKQNTTASGC----ELMHTEMQALR 2927

Query: 829  LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVS 870
               K+    + + +  L+   SQ  LS      E + SG V+
Sbjct: 2928 ADWKQWEDSVFQTQSCLENLVSQMALS------EQEFSGQVA 2963


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score =  965 bits (2495), Expect = 0.0
 Identities = 526/985 (53%), Positives = 668/985 (67%), Gaps = 58/985 (5%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            MG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET   +QQLDKNMS+LR
Sbjct: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            TWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD D
Sbjct: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            ACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+
Sbjct: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A  L
Sbjct: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRL 6215

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            KQMVHEGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+SILVWLTEMDLQLTN+EHFS
Sbjct: 6216 KQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFS 6275

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            E D   K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEPLDA +IE+EL+EL RYCQE
Sbjct: 6276 ESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335

Query: 361  VFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
            VFGRV R+H++L    P  +DE + S+ E ++ED   +    W  R      S +PSS  
Sbjct: 6336 VFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQ 6391

Query: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
            SL        ERSG +TP SVDSIPLEWDH  D+          +   EDEEG     +Y
Sbjct: 6392 SLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG-------GSSSHEEDEEG----PYY 6440

Query: 480  LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 539
                  LSDV IPE+PEAY+K+T   +K +SG  S  +     +  +        +Q E 
Sbjct: 6441 ----SALSDVEIPENPEAYLKMTTKTLKASSG-KSISDGHSWHVPDSPSCPEHHYKQMEG 6495

Query: 540  IIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              R+  P  P   T YK   G + L        +  + L    ++E+  L G        
Sbjct: 6496 -DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE----- 6549

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
             Q +G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L+  + 
Sbjct: 6550 -QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP 6605

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
             +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W
Sbjct: 6606 PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 6665

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            +     ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D   L + 
Sbjct: 6666 EAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 6725

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L ++VS 
Sbjct: 6726 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS- 6784

Query: 837  HIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPS 896
                 + L+ +  +Q   S   S DE+D SG   P +                 S P P 
Sbjct: 6785 -----QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT-----------------SVPAPR 6821

Query: 897  VSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEED 956
                  R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P SEED
Sbjct: 6822 AKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEED 6881

Query: 957  YSCALSNNFARSFHPMLRYTNGPPP 981
            YSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 6882 YSCTQANNFARSFYPMLRYTNGPPP 6906



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 66/361 (18%), Positives = 157/361 (43%), Gaps = 23/361 (6%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE+L   +       +  ++ ++ D W+ +   +A  +K+ + T+    Q +K +  L++
Sbjct: 5765 GEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKS 5824

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
             L  ++++   P+        E+   L+ ++EL +++E+        L   + +  D   
Sbjct: 5825 RLQVLKAQSEDPL-------PELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR 5877

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
                 +   +++   +L R+W ++C     R+ +IE+    W  F +       WL   E
Sbjct: 5878 HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME 5937

Query: 182  R---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
                  A  S   +I  + K+ +++   F     E   QL+ +  Q  + + ++R   A 
Sbjct: 5938 NKVLQTADISIEEMIEKLQKDCMEEINLFS----ENKLQLKQMGDQLIKASNKSR---AA 5990

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
             +   +++ N RW +L   + S +++LK      ++ +    ++  WL  ++ +L+    
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050

Query: 299  FSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
            +  CD   +Q ++ + +  Q++I  +   +E +    + L+  S   DA   E E D ++
Sbjct: 6051 YDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDS---DACANETECDSIQ 6107

Query: 356  R 356
            +
Sbjct: 6108 Q 6108



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 146/799 (18%), Positives = 302/799 (37%), Gaps = 132/799 (16%)

Query: 28   WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK 87
            W++   L+   +++    L  ++Q     S L T +   ES ++    Y     E ++++
Sbjct: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASY--MGKENLKKR 1573

Query: 88   LNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 147
            + E + ++ +  +H   V  +  +C+ L    +   T  E    ++A   +DR W +I  
Sbjct: 1574 IAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR-WLDINE 1632

Query: 148  MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 207
             + +    +     LW K  +  +  ++W + +                    L+K E  
Sbjct: 1633 KTEDYYENLGRALALWDKLFNLKNVIDEWTEKA--------------------LQKMELH 1672

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 267
            Q                   L  E+R      LK+ +    Q+     +RV  I      
Sbjct: 1673 Q-------------------LTEEDRE----RLKEELQVHEQKTSEFSRRVAEI------ 1703

Query: 268  FIGQREEFETARDSILVWLTEMDLQLTN-IEHFSECDV-QAKIKQLKAFQQEISLNHNKI 325
                  +F      I + L  M+  + N +EH  +C   ++    L     E+  + ++ 
Sbjct: 1704 ------QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757

Query: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
            +  I   E L++   P D+  I  +L+E+++   +     +++   L+   +     +LS
Sbjct: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ-----QKHSMILLENQIGCLTPELS 1812

Query: 386  DRELELEDSAALSDLHWHDRSA-----DSLLSPQPS------SNLSLSLAQPLRSERSGR 434
            + + + E   ++SDL    +S        LL+ Q        SN+ ++L +   S  +  
Sbjct: 1813 ELKKQYE---SVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSET-- 1867

Query: 435  DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 494
                                + +E  + +       EG++ K   ++    +   +    
Sbjct: 1868 -------------------KKSVEQKLQKLSDFLTLEGRNSK---IKQVDSVLKHVKKHL 1905

Query: 495  PEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
            P+A+VK   + +     +   +ES  +   K L+DS  Q+ + ++  R+        +  
Sbjct: 1906 PKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEK 1965

Query: 555  YKG----------YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID 604
            +KG          + + L       +SV +L + LKE      GF        +   ++D
Sbjct: 1966 WKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEY-----GFTEEEEIIMEATCLMD 2020

Query: 605  RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664
            R++ L  Q    E   K    + Q FN   + +  W+   +E  E L  L  S     +E
Sbjct: 2021 RYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI---KEIKESLMVLNSSEGKMPLE 2077

Query: 665  LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLE 724
             +I+K+KE+        A I +I        QA+S E+  +Q  L+ ++ +WD    L  
Sbjct: 2078 ERIQKIKEIILLKPEGDARIETI------MKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131

Query: 725  EWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIK 784
             +    +  L++ + + +    L LML  + +++     +        LQ+   QL   K
Sbjct: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-----LQEKKAQLKIYK 2186

Query: 785  HELLESQLRVASLQDMSCQ 803
              L ++Q   + L+++  Q
Sbjct: 2187 KFLKKAQDLTSLLKELKSQ 2205



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 128/669 (19%), Positives = 264/669 (39%), Gaps = 77/669 (11%)

Query: 41   KLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 100
            KL+  L   ++ D+N +SL   L  + S L    + +    E +  +++  Q+++R+I  
Sbjct: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE-TEERLVERISFYQQIKRNIGG 4890

Query: 101  HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE-ET 159
                +   LN  + L+           C  ++     L+ +W     +S+ +++  E   
Sbjct: 4891 KHARLYQTLNEGKQLV-------ASVSCPELEGQIAKLEEQW-----LSLNKKIDHELHR 4938

Query: 160  WRLWQKFLDDYSRFED----WLKSSERTAAFPSSSGVIYT----VAKEELKKFEAFQRQV 211
             +   K L  Y+R  D    WL+SS+ T  +     +  +      +  +  F  F ++V
Sbjct: 4939 LQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEV 4998

Query: 212  HECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ 271
             E  +    +     +L     TD+A +L+  + +  Q+W  L  ++  I  +L     +
Sbjct: 4999 DEKSSLKTAVISIGNQLLHLKETDTA-TLRASLAQFEQKWTMLITQLPDIQEKLHQLQME 5057

Query: 272  REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL----KAFQQEISLNH---NK 324
            +     A   ++ W+  ++ Q ++ +        +++K L    K F+ E+       + 
Sbjct: 5058 KLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF 5117

Query: 325  IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 384
            + Q + Q      +S+  +     E L E+ R    V G + R  + L +L     E   
Sbjct: 5118 VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE--- 5174

Query: 385  SDRELELEDSAALSDLHWHDRSADSLLSPQ-PSSNLSLSLAQPLRSERSGRDTPASVDSI 443
            S+ ++++ +       +W +   + L + Q P S +S+   Q L  +    +   ++ S 
Sbjct: 5175 SENKIQILN-------NWLEAQEERLKTLQKPESVISV---QKLLLDCQDIENQLAIKSK 5224

Query: 444  PLEWDHDYDLSRDLESAMSRALP-SEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
             L+     +L +   +  S A+P  ED   + D+ F  R +V                LT
Sbjct: 5225 ALD-----ELKQSYLTLESGAVPLLEDTASRIDELFQKRSSV----------------LT 5263

Query: 503  ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT---SYKGYM 559
            +     TS      E +I    +  D+      +    +    P    L+T     +   
Sbjct: 5264 QVNQLKTSMQSVLQEWKI--YDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQ 5321

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
             L  E  SS  S ++L+  + + +   P    +   E +      RW  +  QA++ +L+
Sbjct: 5322 SLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEI--IEEKCQNTHKRWTQVN-QAIADQLQ 5378

Query: 620  MKQN-LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD--IQTIELQIKKLKELQKA 676
              Q+ LQ W+ +++      A L   E + +QL  + +S +   + +   ++ +KELQ  
Sbjct: 5379 KAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHD 5438

Query: 677  VDHRKAIIL 685
            V   K   L
Sbjct: 5439 VQKTKEAFL 5447



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 56/290 (19%), Positives = 127/290 (43%), Gaps = 9/290 (3%)

Query: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
            E + L   V+    E Q A + ++W  L  +   +  R++  L+    +N D + +  WL
Sbjct: 4901 EGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWL 4960

Query: 642  GDTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699
              ++  L   + Q L +S D+ TI   I    E  K VD + ++  ++     +      
Sbjct: 4961 ESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
             ++  L+  L+Q   +W  + + L + +  L    M+     +    ++  + N++ + +
Sbjct: 5021 TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080

Query: 760  EIVPIDSNLDA----EILQDHHKQLMQIKH-ELLESQLRVASLQDMSCQL-LVNAEGTDC 813
            +   + S   A     +LQ H +  M++ + + +   +  + LQ  +C +     E T+ 
Sbjct: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEF 5140

Query: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKE-LEKLLDVSSSQQDLSSWSSADE 862
             E   +++   +R+  +L    +H+++ LE + +  +  Q L++W  A E
Sbjct: 5141 AEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 68/357 (19%), Positives = 146/357 (40%), Gaps = 16/357 (4%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            +  K+ DRWQ+ +  +  R   +   +   Q    ++ +L  +L      L+     +  
Sbjct: 5673 EFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERF 5732

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            +  + +  ++E +  +   ++  T  A  L   E LL   D    +    S+ +    L 
Sbjct: 5733 SLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE----SVGRRISQLQ 5788

Query: 140  RRWRNI---CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
              W+++    A  +++     ETW   +K + +       LK+       P     ++  
Sbjct: 5789 DSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP-LPELHEDLHN- 5846

Query: 197  AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 256
             KE +K+ E       + L +L+ +      L R    +    LK+ +   +++W++L  
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKAD---LTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903

Query: 257  RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL-KAFQ 315
            RV    + ++  +     F      +  WL +M+     +   ++  ++  I++L K   
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCM 5960

Query: 316  QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
            +EI+L      Q+   G+QLI+ S    AA I+++L+++    Q +F  +    KKL
Sbjct: 5961 EEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 78/381 (20%), Positives = 156/381 (40%), Gaps = 35/381 (9%)

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 576
            E +I++L      SR Q+ + +    S+ P  PEL        +L+ E   S+ S  +  
Sbjct: 5816 EKKIKEL-----KSRLQVLKAQ----SEDPL-PELHEDLHNEKELIKELEQSLASWTQNL 5865

Query: 577  HKLKEEEESLPGFVNLHST---ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 633
             +L+  +  L   V +      + Q   +  +WE L  +   ++  ++  L  W  FN  
Sbjct: 5866 KELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 693
               + AWL   E ++  LQ  ++S +    +LQ   ++E+    +++    L +     +
Sbjct: 5926 NKELCAWLVQMENKV--LQTADISIEEMIEKLQKDCMEEINLFSENK----LQLKQMGDQ 5979

Query: 694  FTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 752
              +A +K  + ++ D+L+++N RW  +  ++      L++     Q   +    L   L 
Sbjct: 5980 LIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA 6039

Query: 753  NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN----- 807
             I+   ++ V  D   D EI Q    +   ++ ++ +    V S+ ++ C +L++     
Sbjct: 6040 RIESELSKPVVYDVCDDQEI-QKRLAEQQDLQRDIEQHSAGVESVFNI-CDVLLHDSDAC 6097

Query: 808  AEGTDCLEAKEKVHVIGNRLK-LLLKEVSRHIKELE------KLLDVSSSQQD-LSSWSS 859
            A  T+C   ++    +  R + +    + R +K  E      K LD  S  +D L S   
Sbjct: 6098 ANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER 6157

Query: 860  ADELDTSGSVSPTSGRSTPNR 880
                  S  V  TS +    R
Sbjct: 6158 TAACPNSSEVLYTSAKEELKR 6178



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 96/461 (20%), Positives = 167/461 (36%), Gaps = 79/461 (17%)

Query: 27   RWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQR 86
            ++Q +      R  +L +  V +++    + S   W+ +    LA P  YDS  +     
Sbjct: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLS-HH 3823

Query: 87   KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 146
                Q  L+   +KH        NL   +  D +  +   E D + Q+ + L  +   + 
Sbjct: 3824 ASTVQMALEDSEQKH--------NLLHSIFMDLEDLSIIFETDELTQSIQELSNQ---VT 3872

Query: 147  AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS---SGVIYTVAKEE--- 200
            A+      KI E+    Q+  DD    E  +KS E+  +   +   S  I+  + EE   
Sbjct: 3873 ALQQ----KIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLK 3928

Query: 201  -----LKKFEAFQRQVHECLT---QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWD 252
                 L+     ++ + E ++   +L L     + L    RT+      +++    Q  +
Sbjct: 3929 HGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQN 3988

Query: 253  NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL- 311
             L          LK  I Q  E++   +++   L     Q  ++EH S  D   K+ QL 
Sbjct: 3989 EL----------LKVVIKQTNEWDEEIENLKQILNNYSAQF-SLEHMSP-DQADKLPQLQ 4036

Query: 312  ----KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 367
                +  +Q +SLN  K + ++     ++   + L       E D L     E  G  ER
Sbjct: 4037 GEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAER 4096

Query: 368  YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 427
               +  +L        L+  E E+E+S+  SD      + D    P P S  SL      
Sbjct: 4097 DASER-KLNRRGSMSYLAAVEEEVEESSVKSD------NGDEKAEPSPQSWSSL------ 4143

Query: 428  RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE 468
                               W HD D+  D  S+ S  +  E
Sbjct: 4144 -------------------WKHDKDMEEDRASSSSGTIVQE 4165



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 152/845 (17%), Positives = 323/845 (38%), Gaps = 145/845 (17%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL---AHIESELAK 72
            E+E ++ K+ ++W  L   I   + +L+  L  +   +++   L  WL    H  +   +
Sbjct: 4913 ELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972

Query: 73   PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 132
              +  S + + I+  +N   E  +++++ S+   +V+++   LLH       + +  +++
Sbjct: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLH-----LKETDTATLR 5027

Query: 133  QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK------SSERTAAF 186
             +    +++W  +     + + K+ +            +    W+       S E +   
Sbjct: 5028 ASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHS 5087

Query: 187  PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACS 239
            PSS+  +    K  L+K + F+ ++      ++ +N+   +L+       R  RT+ A  
Sbjct: 5088 PSSASQV----KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEH 5143

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
            L +M    N++W  +   +    R+++H            + +L  +TE + ++  + ++
Sbjct: 5144 LGEM----NRQWHRVHGMLN---RKIQHL-----------EQLLESITESENKIQILNNW 5185

Query: 300  SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE-PLDAAIIEEELDELRR-Y 357
                ++A+ ++LK  Q        K E +I+  + L++  +     AI  + LDEL++ Y
Sbjct: 5186 ----LEAQEERLKTLQ--------KPESVISVQKLLLDCQDIENQLAIKSKALDELKQSY 5233

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----- 412
                 G V          PL +D     D EL  + S+ L+ ++    S  S+L      
Sbjct: 5234 LTLESGAV----------PLLEDTASRID-ELFQKRSSVLTQVNQLKTSMQSVLQEWKIY 5282

Query: 413  PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
             Q    +++   +        +    S++++  +          +E+  S    +E  EG
Sbjct: 5283 DQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQ----------VENLQSLQDEAESSEG 5332

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR------QLGKA 526
              +K   L+  +G    + P   E   +  +N  K  +  + A+  Q++      QL KA
Sbjct: 5333 SWEK---LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389

Query: 527  LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 586
              ++  +         +K      +  S     ++L     ++  +K L+H +++ +E+ 
Sbjct: 5390 YSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL---PPALQDIKELQHDVQKTKEAF 5446

Query: 587  PGFVNLHSTETQTAGVIDR-----------------WELLQAQALSKELRMKQN-----L 624
                       Q + V+DR                   L +A  L K L +K N     L
Sbjct: 5447 ----------LQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVL 5496

Query: 625  QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 684
             +++ F   L S+   +   EE L++L + E       +   +  L      ++H   + 
Sbjct: 5497 SQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLN-HVLALTAQSPDIEHLNEVS 5555

Query: 685  LSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS 744
            L + L            S      L  MN +W R  +   E    LQ   +  + F    
Sbjct: 5556 LKLPL------------SDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCC 5602

Query: 745  HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
               + +LE I+    E + +D       L +  K    ++ E+  +Q    S    S QL
Sbjct: 5603 EKWIQLLEKIE----EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQL 5658

Query: 805  LVNAE 809
            L   E
Sbjct: 5659 LDTTE 5663



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 65/322 (20%), Positives = 128/322 (39%), Gaps = 27/322 (8%)

Query: 549  PELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGVI 603
            PEL    K Y  L  E S +    DS      +L +  E E+ P F+      T+ + + 
Sbjct: 5625 PELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI------TEFSKLT 5678

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            DRW+        ++  +   +++WQ F + + +++ +L DT   L  ++  E  +  QT 
Sbjct: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTR 5738

Query: 664  ELQIKKLKELQKAVDHRK-AIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
             L I +LK  +     R+    L++          D K    +  R+SQ+   W  +   
Sbjct: 5739 SL-IHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQ 5797

Query: 723  LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQ--- 779
            L E     Q  +       +    L   L+ +  +  + +P       E+ +D H +   
Sbjct: 5798 LAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLP-------ELHEDLHNEKEL 5850

Query: 780  LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
            + +++  L      +  LQ M   L  +    D +  KE++  +  + + L   V+   +
Sbjct: 5851 IKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQ 5910

Query: 840  ELEKLLDV----SSSQQDLSSW 857
            E+E  L+     +   ++L +W
Sbjct: 5911 EIEDRLNTWVVFNEKNKELCAW 5932



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 157/878 (17%), Positives = 353/878 (40%), Gaps = 133/878 (15%)

Query: 59   LRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
            L  W  ++E+       ++    EEI +++  +   Q ++E H+T   +   L EV    
Sbjct: 585  LACWATYVENLRLLRACFEETKKEEI-KEVPFETLAQWNLE-HATLNEAGNFLVEV---- 638

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMS-MERRLKIEETWRLWQKFLDDYSRFEDWL 177
                + D    SI +  R L++RWR + + + +E  L +    +    F +  +      
Sbjct: 639  ----SNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEE 694

Query: 178  K-----SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQ------VHECLTQLELINKQYR 226
            K     S++ +   P +        ++  K+ E F  Q      V + + Q+E+   + +
Sbjct: 695  KATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAK 754

Query: 227  RLARENRTDSAC--SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-------- 276
             +  ++  D++   SLK ++ +G+  +D L  R   +L+     I  +E F+        
Sbjct: 755  SVLDQDDVDTSMEESLKHLIAKGSM-FDELMARSEDMLQMDIQNISSQESFQHVLTTGLQ 813

Query: 277  ----TARDSILVWLTEMDLQLTNIEHFS-ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 331
                 A++ + + + ++   L N+   S + D++ K+++    Q+E+     + +Q++ Q
Sbjct: 814  AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEES---QKELESYMMRAQQLLGQ 870

Query: 332  GEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDR---- 387
             E   E       A+I      L +Y + V   ++    + I++ L +   D+  +    
Sbjct: 871  RESPGELISKHKEALIISNTKSLAKYLKAV-EELKNNVTEDIKMSLEEKSRDVCAKWESL 929

Query: 388  --ELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPA--SVDSI 443
              EL L       D+    + +D++L  +   N    L +  R++   ++  A  S +  
Sbjct: 930  HHELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGC 988

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
              + +H  ++ R+L       LPS+  + Q +    L+      + ++  + E ++ L  
Sbjct: 989  LYQLNHHMEVLREL----CEELPSQ--KSQQEVKRLLKDYEQKIERLLKCASEIHMTLQP 1042

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLG 563
             A   TS +   + +   + G    ++ F   +++N   ++    P +  S    ++ L 
Sbjct: 1043 TA-GGTSKNEGTITTSENRGGDPHSEAPFA--KSDNQPSTEKAMEPTMKFSLASVLRPLQ 1099

Query: 564  E-------CSSSIDSVKR--------LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWEL 608
            E        S+SI+S+          LEH L+  +  +    +  S E +++        
Sbjct: 1100 EESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITS--DFSSEEDRSSSC------ 1151

Query: 609  LQAQALSKELRMKQNLQKWQQFN-------SDLNSIWAWL----GDTEEELEQLQRLELS 657
            LQA+    ++   +   +W++F        + +N I         DT +E E+  ++ L+
Sbjct: 1152 LQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLN 1211

Query: 658  TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT-QADSKESRDLQDRLSQMNGRW 716
            T ++++E  ++ +  ++KA         S+ LC  +      + +   L D         
Sbjct: 1212 TRMESLETALRLVLPVEKA---------SLLLCGSDLPLHKMAIQGFHLIDA-------- 1254

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            DR+   L   +  +   +  C    E  + +L           E+ P D +    I+  +
Sbjct: 1255 DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVL----------KELHPFDLHAMQNIILKY 1304

Query: 777  HKQLMQIKHELLESQLRVASLQD---------MSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
              Q   + H +  S+  + +L+D         +S + + +   +D   A+E    + N+ 
Sbjct: 1305 KTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKE 1364

Query: 828  KL--LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
                L+K+ ++H+ +  K+LD+S    +    +S + L
Sbjct: 1365 GEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENL 1402



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 122/674 (18%), Positives = 271/674 (40%), Gaps = 99/674 (14%)

Query: 26   DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 85
            DR+Q LL     ++ +++E    +   D++ + L   + H   E+ + ++    NS E +
Sbjct: 2020 DRYQTLL----RQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV--LNSSEGK 2073

Query: 86   RKLNEQ-QELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN 144
              L E+ Q+++  I     G A +  + +         A  +E   +Q+   ++  +W N
Sbjct: 2074 MPLEERIQKIKEIILLKPEGDARIETIMKQ--------AESSEAPLVQKTLTDISNQWDN 2125

Query: 145  ICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGVIYTVAKEELK 202
               ++       E+     +K+L         L     ++ A F    G+     K +LK
Sbjct: 2126 TLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGL--QEKKAQLK 2183

Query: 203  KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 262
             ++ F ++  +  + L+ +  Q   L    +  S            + W  ++    S+L
Sbjct: 2184 IYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSF---------SEEPWLEIKHLHESLL 2234

Query: 263  RRLKHFIGQREEFETARDSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKA 313
            ++L+  +   +      DS  V +T+++  L N   E  S  D       V+ K+++L+ 
Sbjct: 2235 QQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQE 2294

Query: 314  FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI 373
             +  +SL    +++I+A  + + + +  +   II++++  L+  C++             
Sbjct: 2295 LENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ--CKQ------------- 2339

Query: 374  RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSG 433
                 D E+ L+  + E+E               +S+L  + S+        P R +++ 
Sbjct: 2340 ----KDLENRLASAKQEMECCL------------NSILKSKRSTEKKGKFTLPGREKQAT 2383

Query: 434  RDTPASV-DSIPLE-WDHDYDLSRD--LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDV 489
             D   S  +S  +E  + D+++++D  +E AMS+ L    +E   + +          + 
Sbjct: 2384 SDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTE---------DER 2434

Query: 490  MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGP 549
             + E     ++L          +   L +Q+     A+      ++QTE +  +KT TG 
Sbjct: 2435 KVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKP----LEQTECL--NKTETGA 2488

Query: 550  ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
             +       +  +G  +  +D++ +    LK+ +ES   +  L   +   A V    + L
Sbjct: 2489 LV-------LHNIGYSAQHLDNLLQALITLKKNKESQ--YCVLRDFQEYLAAVESSMKAL 2539

Query: 610  QAQALSKELRMKQN---LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 666
                 S ++    +   L K ++F + +      LG+ + + E L       D + +E Q
Sbjct: 2540 LTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQ 2599

Query: 667  IKKLKELQKAVDHR 680
            IK+L+   + V+ +
Sbjct: 2600 IKQLEHGWEQVEQQ 2613



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
           W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361

Query: 666 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 721
              +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
           L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459

Query: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 829
              ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517

Query: 830 LLKEVSRHIKELEKLLDVSSSQQ 852
           LL++  + I+E E L  + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 122/752 (16%), Positives = 279/752 (37%), Gaps = 88/752 (11%)

Query: 11   ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
            E+  + +   L +   +W  L+  +    +KL +  +      K ++ + +W+ ++E + 
Sbjct: 5020 ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQT 5079

Query: 71   A-KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 129
            + +  V+   ++ +++  L + +E + +++ +   +   +N   + L  CD  +   E  
Sbjct: 5080 SDEDSVHSPSSASQVKHLLQKHKEFRMEMD-YKQWIVDFVNQSLLQLSTCDVESKRYERT 5138

Query: 130  SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 189
               +    ++R+W  +  M   +   +E+      +  +      +WL++ E        
Sbjct: 5139 EFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQK 5198

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
               + +V K  L           +   QL + +K    L +   T  + ++  ++ +   
Sbjct: 5199 PESVISVQKLLL--------DCQDIENQLAIKSKALDELKQSYLTLESGAV-PLLEDTAS 5249

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSIL-VW------LTEMDLQLTN----IEH 298
            R D L ++ +S+L        Q  + +T+  S+L  W        E+++        +EH
Sbjct: 5250 RIDELFQKRSSVLT-------QVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEH 5302

Query: 299  -----FSECDVQAKIKQLKAFQQEISLNH---NKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
                  S   ++ +++ L++ Q E   +     K++++I + + L     P  A IIEE+
Sbjct: 5303 SKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC----PSVAEIIEEK 5358

Query: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
                   CQ    R  + ++ +       D+   +   L+L  + + +      R     
Sbjct: 5359 -------CQNTHKRWTQVNQAIA------DQLQKAQSLLQLWKAYSNAHGEAAARLKQQE 5405

Query: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
               Q  +N+S+S              P ++  I  E  HD   +++     S  L    +
Sbjct: 5406 AKFQQLANISMS------GNNLAEILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ 5458

Query: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
              +      L G         P          E  +   + +   + SQ +  G  L+  
Sbjct: 5459 PAESSTHMLLPG---------PLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESL 5509

Query: 531  RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 590
            +  I   E  +        E   S+  ++  L   S  I+ +  +  KL   + ++    
Sbjct: 5510 KGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ 5569

Query: 591  NLHSTETQ-TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
            N++    + TA  ++R   LQ   L++  +     +KW Q                E++E
Sbjct: 5570 NMNRQWIRATATALERCSELQGIGLNE--KFLYCCEKWIQL--------------LEKIE 5613

Query: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDR 708
            +  +++++  +  +  Q K  K L+  V   + I  S    S +       E+R +    
Sbjct: 5614 EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE 5673

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 740
             S++  RW      + + +G +   + Q Q F
Sbjct: 5674 FSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDF 5705



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 57/288 (19%), Positives = 105/288 (36%), Gaps = 51/288 (17%)

Query: 605  RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664
            +W  +      K   ++Q L+   +  + +  +  WL   EE L+ LQ+ E    +Q + 
Sbjct: 5150 QWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLL 5209

Query: 665  LQIKKLKE----LQKAVDHRKAIILSINL-CSPEFTQADSKESRDLQDR---LSQMNGRW 716
            L  + ++       KA+D  K   L++     P      S+     Q R   L+Q+N   
Sbjct: 5210 LDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLK 5269

Query: 717  DRVCSLLEEWRGLLQ---------------------------------DALMQCQGFHEM 743
              + S+L+EW+   Q                                 + L   Q   E 
Sbjct: 5270 TSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES 5329

Query: 744  SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 803
            S G    L+ +  +   + P  + +  E  Q+ HK+  Q+   + +   +  SL  +  +
Sbjct: 5330 SEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL-WK 5388

Query: 804  LLVNAEGTDCLEAKEK---------VHVIGNRLKLLLKEVSRHIKELE 842
               NA G      K++         + + GN L  +L    + IKEL+
Sbjct: 5389 AYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 101/626 (16%), Positives = 245/626 (39%), Gaps = 105/626 (16%)

Query: 199  EELKKFEAFQRQVHECLT-----QLELINKQYRRLARE-------------NRTDSACSL 240
            E+ +K    Q Q  E  T     QLE I K Y +L  +             N+T++   +
Sbjct: 2431 EDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALV 2490

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
               +    Q  DNL + + ++ +  +       +F+   + +    + M   LT+ E   
Sbjct: 2491 LHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQ---EYLAAVESSMKALLTDKESLK 2547

Query: 301  --ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
                D    + ++K F   I    + +  +  + E L      +D  ++E ++ +L    
Sbjct: 2548 VGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGW 2607

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS-PQPSS 417
            ++V  ++++ +               S + +E ++   L +     +  D+ +S  Q   
Sbjct: 2608 EQVEQQIQKKY---------------SQQVVEYDEFTTLMN-----KVQDTEISLQQQQQ 2647

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD-LSRDLESAMSRALPSEDEEGQDDK 476
            +L L L  P   ER+G  +  ++ +      H +  L    E  M R    ++++  +D 
Sbjct: 2648 HLQLRLKSP--EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLED- 2704

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQ 536
                    G++++             +   +     H   E+QI++      D R ++++
Sbjct: 2705 --------GINNL-------------KKQWETLEPLHLEAENQIKKC-----DIRNKMKE 2738

Query: 537  T----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV----KRLEHKLKEEEESLPG 588
            T    +N++    P+ P L       ++   +C  + D +    + +E   +E ++ +P 
Sbjct: 2739 TILWAKNLLGELNPSIPLLPDDILSQIR---KCKVTHDGILARQQSVESLAEEVKDKVPS 2795

Query: 589  FVNLHSTETQTA--GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 646
                  ++       + +++++L  ++  +  +++  L++   F + +      + ++E 
Sbjct: 2796 LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESET 2855

Query: 647  EL-----EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
             +           EL     T+E   K+L+E+   +      + +I      + + +  E
Sbjct: 2856 LIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI------YEELNVFE 2909

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 761
               L+D+L  +  R +R+   ++     ++  +  C+ FHE +  L    ++I R  NE+
Sbjct: 2910 RLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQR--NEL 2967

Query: 762  VPIDSNLDAEILQDHHKQLMQIKHEL 787
            +     L+ E+ +   +++  +K  L
Sbjct: 2968 L-----LNQEVNKGVKEEIYNLKDRL 2988



 Score = 31.2 bits (69), Expect = 5.0
 Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 2/90 (2%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
            S   + +E    LG++N +W  +  ++  +++ L++ L ++ + +  +  L  WL   E 
Sbjct: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191

Query: 69   ELAKPIVYDSCNSEEIQRKLNEQQELQRDI 98
             L      +S  S  +Q+ L + Q+++  +
Sbjct: 5192 RLKTLQKPESVIS--VQKLLLDCQDIENQL 5219


>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
            [Homo sapiens]
          Length = 6885

 Score =  935 bits (2416), Expect = 0.0
 Identities = 514/985 (52%), Positives = 650/985 (65%), Gaps = 80/985 (8%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            MG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKKLKET   +QQLDKNMS+LR
Sbjct: 5976 MGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLR 6035

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            TWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+HS GV SV N+C+VLLHD D
Sbjct: 6036 TWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSD 6095

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            ACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWRLWQKFLDDYSRFEDWLKS+
Sbjct: 6096 ACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSA 6155

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELINKQYRRLARENRTD+A  L
Sbjct: 6156 ERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRL 6215

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            KQMVHEGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+SILVWLTEMDLQLTN+EHFS
Sbjct: 6216 KQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFS 6275

Query: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
            E D   K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEPLDA +IE+EL+EL RYCQE
Sbjct: 6276 ESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQE 6335

Query: 361  VFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
            VFGRV R+H++L    P  +DE + S+ E ++ED   +    W  R      S +PSS  
Sbjct: 6336 VFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTDSWRKRGE----SEEPSSPQ 6391

Query: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
            SL        ERSG +TP SVDSIPLEWDH  D+          +   EDEEG       
Sbjct: 6392 SLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG-------GSSSHEEDEEGPYYSALS 6444

Query: 480  LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 539
             +         +P+SP       E+  K   GD                           
Sbjct: 6445 GKSISDGHSWHVPDSPSC----PEHHYKQMEGD--------------------------- 6473

Query: 540  IIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              R+  P  P   T YK   G + L        +  + L    ++E+  L G        
Sbjct: 6474 --RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE----- 6526

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
             Q +G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L+  + 
Sbjct: 6527 -QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP 6582

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
             +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W
Sbjct: 6583 PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLW 6642

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            +     ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D   L + 
Sbjct: 6643 EAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLEC 6702

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L ++VS 
Sbjct: 6703 RRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS- 6761

Query: 837  HIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPS 896
                 + L+ +  +Q   S   S DE+D SG   P +    P R K  R           
Sbjct: 6762 -----QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------- 6804

Query: 897  VSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEED 956
                  R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P SEED
Sbjct: 6805 -----VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEED 6859

Query: 957  YSCALSNNFARSFHPMLRYTNGPPP 981
            YSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 6860 YSCTQANNFARSFYPMLRYTNGPPP 6884



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 66/361 (18%), Positives = 157/361 (43%), Gaps = 23/361 (6%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE+L   +       +  ++ ++ D W+ +   +A  +K+ + T+    Q +K +  L++
Sbjct: 5765 GEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKS 5824

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
             L  ++++   P+        E+   L+ ++EL +++E+        L   + +  D   
Sbjct: 5825 RLQVLKAQSEDPL-------PELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR 5877

Query: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
                 +   +++   +L R+W ++C     R+ +IE+    W  F +       WL   E
Sbjct: 5878 HVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME 5937

Query: 182  R---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
                  A  S   +I  + K+ +++   F     E   QL+ +  Q  + + ++R   A 
Sbjct: 5938 NKVLQTADISIEEMIEKLQKDCMEEINLFS----ENKLQLKQMGDQLIKASNKSR---AA 5990

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
             +   +++ N RW +L   + S +++LK      ++ +    ++  WL  ++ +L+    
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050

Query: 299  FSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
            +  CD   +Q ++ + +  Q++I  +   +E +    + L+  S   DA   E E D ++
Sbjct: 6051 YDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDS---DACANETECDSIQ 6107

Query: 356  R 356
            +
Sbjct: 6108 Q 6108



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 146/799 (18%), Positives = 302/799 (37%), Gaps = 132/799 (16%)

Query: 28   WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK 87
            W++   L+   +++    L  ++Q     S L T +   ES ++    Y     E ++++
Sbjct: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASY--MGKENLKKR 1573

Query: 88   LNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 147
            + E + ++ +  +H   V  +  +C+ L    +   T  E    ++A   +DR W +I  
Sbjct: 1574 IAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR-WLDINE 1632

Query: 148  MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 207
             + +    +     LW K  +  +  ++W + +                    L+K E  
Sbjct: 1633 KTEDYYENLGRALALWDKLFNLKNVIDEWTEKA--------------------LQKMELH 1672

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 267
            Q                   L  E+R      LK+ +    Q+     +RV  I      
Sbjct: 1673 Q-------------------LTEEDRE----RLKEELQVHEQKTSEFSRRVAEI------ 1703

Query: 268  FIGQREEFETARDSILVWLTEMDLQLTN-IEHFSECDV-QAKIKQLKAFQQEISLNHNKI 325
                  +F      I + L  M+  + N +EH  +C   ++    L     E+  + ++ 
Sbjct: 1704 ------QFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQA 1757

Query: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
            +  I   E L++   P D+  I  +L+E+++   +     +++   L+   +     +LS
Sbjct: 1758 KTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ-----QKHSMILLENQIGCLTPELS 1812

Query: 386  DRELELEDSAALSDLHWHDRSA-----DSLLSPQPS------SNLSLSLAQPLRSERSGR 434
            + + + E   ++SDL    +S        LL+ Q        SN+ ++L +   S  +  
Sbjct: 1813 ELKKQYE---SVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSET-- 1867

Query: 435  DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 494
                                + +E  + +       EG++ K   ++    +   +    
Sbjct: 1868 -------------------KKSVEQKLQKLSDFLTLEGRNSK---IKQVDSVLKHVKKHL 1905

Query: 495  PEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
            P+A+VK   + +     +   +ES  +   K L+DS  Q+ + ++  R+        +  
Sbjct: 1906 PKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEK 1965

Query: 555  YKG----------YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID 604
            +KG          + + L       +SV +L + LKE      GF        +   ++D
Sbjct: 1966 WKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEY-----GFTEEEEIIMEATCLMD 2020

Query: 605  RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664
            R++ L  Q    E   K    + Q FN   + +  W+   +E  E L  L  S     +E
Sbjct: 2021 RYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI---KEIKESLMVLNSSEGKMPLE 2077

Query: 665  LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLE 724
             +I+K+KE+        A I +I        QA+S E+  +Q  L+ ++ +WD    L  
Sbjct: 2078 ERIQKIKEIILLKPEGDARIETI------MKQAESSEAPLVQKTLTDISNQWDNTLHLAS 2131

Query: 725  EWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIK 784
             +    +  L++ + + +    L LML  + +++     +        LQ+   QL   K
Sbjct: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-----LQEKKAQLKIYK 2186

Query: 785  HELLESQLRVASLQDMSCQ 803
              L ++Q   + L+++  Q
Sbjct: 2187 KFLKKAQDLTSLLKELKSQ 2205



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 128/669 (19%), Positives = 264/669 (39%), Gaps = 77/669 (11%)

Query: 41   KLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEK 100
            KL+  L   ++ D+N +SL   L  + S L    + +    E +  +++  Q+++R+I  
Sbjct: 4832 KLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE-TEERLVERISFYQQIKRNIGG 4890

Query: 101  HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE-ET 159
                +   LN  + L+           C  ++     L+ +W     +S+ +++  E   
Sbjct: 4891 KHARLYQTLNEGKQLV-------ASVSCPELEGQIAKLEEQW-----LSLNKKIDHELHR 4938

Query: 160  WRLWQKFLDDYSRFED----WLKSSERTAAFPSSSGVIYT----VAKEELKKFEAFQRQV 211
             +   K L  Y+R  D    WL+SS+ T  +     +  +      +  +  F  F ++V
Sbjct: 4939 LQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEV 4998

Query: 212  HECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQ 271
             E  +    +     +L     TD+A +L+  + +  Q+W  L  ++  I  +L     +
Sbjct: 4999 DEKSSLKTAVISIGNQLLHLKETDTA-TLRASLAQFEQKWTMLITQLPDIQEKLHQLQME 5057

Query: 272  REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL----KAFQQEISLNH---NK 324
            +     A   ++ W+  ++ Q ++ +        +++K L    K F+ E+       + 
Sbjct: 5058 KLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF 5117

Query: 325  IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 384
            + Q + Q      +S+  +     E L E+ R    V G + R  + L +L     E   
Sbjct: 5118 VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE--- 5174

Query: 385  SDRELELEDSAALSDLHWHDRSADSLLSPQ-PSSNLSLSLAQPLRSERSGRDTPASVDSI 443
            S+ ++++ +       +W +   + L + Q P S +S+   Q L  +    +   ++ S 
Sbjct: 5175 SENKIQILN-------NWLEAQEERLKTLQKPESVISV---QKLLLDCQDIENQLAIKSK 5224

Query: 444  PLEWDHDYDLSRDLESAMSRALP-SEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
             L+     +L +   +  S A+P  ED   + D+ F  R +V                LT
Sbjct: 5225 ALD-----ELKQSYLTLESGAVPLLEDTASRIDELFQKRSSV----------------LT 5263

Query: 503  ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT---SYKGYM 559
            +     TS      E +I    +  D+      +    +    P    L+T     +   
Sbjct: 5264 QVNQLKTSMQSVLQEWKI--YDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQ 5321

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
             L  E  SS  S ++L+  + + +   P    +   E +      RW  +  QA++ +L+
Sbjct: 5322 SLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEI--IEEKCQNTHKRWTQVN-QAIADQLQ 5378

Query: 620  MKQN-LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD--IQTIELQIKKLKELQKA 676
              Q+ LQ W+ +++      A L   E + +QL  + +S +   + +   ++ +KELQ  
Sbjct: 5379 KAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHD 5438

Query: 677  VDHRKAIIL 685
            V   K   L
Sbjct: 5439 VQKTKEAFL 5447



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 56/290 (19%), Positives = 127/290 (43%), Gaps = 9/290 (3%)

Query: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
            E + L   V+    E Q A + ++W  L  +   +  R++  L+    +N D + +  WL
Sbjct: 4901 EGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWL 4960

Query: 642  GDTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699
              ++  L   + Q L +S D+ TI   I    E  K VD + ++  ++     +      
Sbjct: 4961 ESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
             ++  L+  L+Q   +W  + + L + +  L    M+     +    ++  + N++ + +
Sbjct: 5021 TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTS 5080

Query: 760  EIVPIDSNLDA----EILQDHHKQLMQIKH-ELLESQLRVASLQDMSCQL-LVNAEGTDC 813
            +   + S   A     +LQ H +  M++ + + +   +  + LQ  +C +     E T+ 
Sbjct: 5081 DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEF 5140

Query: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKE-LEKLLDVSSSQQDLSSWSSADE 862
             E   +++   +R+  +L    +H+++ LE + +  +  Q L++W  A E
Sbjct: 5141 AEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 68/357 (19%), Positives = 146/357 (40%), Gaps = 16/357 (4%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            +  K+ DRWQ+ +  +  R   +   +   Q    ++ +L  +L      L+     +  
Sbjct: 5673 EFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERF 5732

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            +  + +  ++E +  +   ++  T  A  L   E LL   D    +    S+ +    L 
Sbjct: 5733 SLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKE----SVGRRISQLQ 5788

Query: 140  RRWRNI---CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
              W+++    A  +++     ETW   +K + +       LK+       P     ++  
Sbjct: 5789 DSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP-LPELHEDLHN- 5846

Query: 197  AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 256
             KE +K+ E       + L +L+ +      L R    +    LK+ +   +++W++L  
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKAD---LTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903

Query: 257  RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL-KAFQ 315
            RV    + ++  +     F      +  WL +M+     +   ++  ++  I++L K   
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQME---NKVLQTADISIEEMIEKLQKDCM 5960

Query: 316  QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
            +EI+L      Q+   G+QLI+ S    AA I+++L+++    Q +F  +    KKL
Sbjct: 5961 EEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 78/381 (20%), Positives = 156/381 (40%), Gaps = 35/381 (9%)

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 576
            E +I++L      SR Q+ + +    S+ P  PEL        +L+ E   S+ S  +  
Sbjct: 5816 EKKIKEL-----KSRLQVLKAQ----SEDPL-PELHEDLHNEKELIKELEQSLASWTQNL 5865

Query: 577  HKLKEEEESLPGFVNLHST---ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 633
             +L+  +  L   V +      + Q   +  +WE L  +   ++  ++  L  W  FN  
Sbjct: 5866 KELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 693
               + AWL   E ++  LQ  ++S +    +LQ   ++E+    +++    L +     +
Sbjct: 5926 NKELCAWLVQMENKV--LQTADISIEEMIEKLQKDCMEEINLFSENK----LQLKQMGDQ 5979

Query: 694  FTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 752
              +A +K  + ++ D+L+++N RW  +  ++      L++     Q   +    L   L 
Sbjct: 5980 LIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLA 6039

Query: 753  NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN----- 807
             I+   ++ V  D   D EI Q    +   ++ ++ +    V S+ ++ C +L++     
Sbjct: 6040 RIESELSKPVVYDVCDDQEI-QKRLAEQQDLQRDIEQHSAGVESVFNI-CDVLLHDSDAC 6097

Query: 808  AEGTDCLEAKEKVHVIGNRLK-LLLKEVSRHIKELE------KLLDVSSSQQD-LSSWSS 859
            A  T+C   ++    +  R + +    + R +K  E      K LD  S  +D L S   
Sbjct: 6098 ANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAER 6157

Query: 860  ADELDTSGSVSPTSGRSTPNR 880
                  S  V  TS +    R
Sbjct: 6158 TAACPNSSEVLYTSAKEELKR 6178



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 96/461 (20%), Positives = 167/461 (36%), Gaps = 79/461 (17%)

Query: 27   RWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQR 86
            ++Q +      R  +L +  V +++    + S   W+ +    LA P  YDS  +     
Sbjct: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLS-HH 3823

Query: 87   KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 146
                Q  L+   +KH        NL   +  D +  +   E D + Q+ + L  +   + 
Sbjct: 3824 ASTVQMALEDSEQKH--------NLLHSIFMDLEDLSIIFETDELTQSIQELSNQ---VT 3872

Query: 147  AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS---SGVIYTVAKEE--- 200
            A+      KI E+    Q+  DD    E  +KS E+  +   +   S  I+  + EE   
Sbjct: 3873 ALQQ----KIMESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLK 3928

Query: 201  -----LKKFEAFQRQVHECLT---QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWD 252
                 L+     ++ + E ++   +L L     + L    RT+      +++    Q  +
Sbjct: 3929 HGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQN 3988

Query: 253  NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL- 311
             L          LK  I Q  E++   +++   L     Q  ++EH S  D   K+ QL 
Sbjct: 3989 EL----------LKVVIKQTNEWDEEIENLKQILNNYSAQF-SLEHMSP-DQADKLPQLQ 4036

Query: 312  ----KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 367
                +  +Q +SLN  K + ++     ++   + L       E D L     E  G  ER
Sbjct: 4037 GEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAER 4096

Query: 368  YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 427
               +  +L        L+  E E+E+S+  SD      + D    P P S  SL      
Sbjct: 4097 DASER-KLNRRGSMSYLAAVEEEVEESSVKSD------NGDEKAEPSPQSWSSL------ 4143

Query: 428  RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE 468
                               W HD D+  D  S+ S  +  E
Sbjct: 4144 -------------------WKHDKDMEEDRASSSSGTIVQE 4165



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 152/845 (17%), Positives = 323/845 (38%), Gaps = 145/845 (17%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL---AHIESELAK 72
            E+E ++ K+ ++W  L   I   + +L+  L  +   +++   L  WL    H  +   +
Sbjct: 4913 ELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972

Query: 73   PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 132
              +  S + + I+  +N   E  +++++ S+   +V+++   LLH       + +  +++
Sbjct: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLH-----LKETDTATLR 5027

Query: 133  QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK------SSERTAAF 186
             +    +++W  +     + + K+ +            +    W+       S E +   
Sbjct: 5028 ASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHS 5087

Query: 187  PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACS 239
            PSS+  +    K  L+K + F+ ++      ++ +N+   +L+       R  RT+ A  
Sbjct: 5088 PSSASQV----KHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEH 5143

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
            L +M    N++W  +   +    R+++H            + +L  +TE + ++  + ++
Sbjct: 5144 LGEM----NRQWHRVHGMLN---RKIQHL-----------EQLLESITESENKIQILNNW 5185

Query: 300  SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE-PLDAAIIEEELDELRR-Y 357
                ++A+ ++LK  Q        K E +I+  + L++  +     AI  + LDEL++ Y
Sbjct: 5186 ----LEAQEERLKTLQ--------KPESVISVQKLLLDCQDIENQLAIKSKALDELKQSY 5233

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----- 412
                 G V          PL +D     D EL  + S+ L+ ++    S  S+L      
Sbjct: 5234 LTLESGAV----------PLLEDTASRID-ELFQKRSSVLTQVNQLKTSMQSVLQEWKIY 5282

Query: 413  PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
             Q    +++   +        +    S++++  +          +E+  S    +E  EG
Sbjct: 5283 DQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQ----------VENLQSLQDEAESSEG 5332

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR------QLGKA 526
              +K   L+  +G    + P   E   +  +N  K  +  + A+  Q++      QL KA
Sbjct: 5333 SWEK---LQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKA 5389

Query: 527  LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 586
              ++  +         +K      +  S     ++L     ++  +K L+H +++ +E+ 
Sbjct: 5390 YSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL---PPALQDIKELQHDVQKTKEAF 5446

Query: 587  PGFVNLHSTETQTAGVIDR-----------------WELLQAQALSKELRMKQN-----L 624
                       Q + V+DR                   L +A  L K L +K N     L
Sbjct: 5447 ----------LQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVL 5496

Query: 625  QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 684
             +++ F   L S+   +   EE L++L + E       +   +  L      ++H   + 
Sbjct: 5497 SQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLN-HVLALTAQSPDIEHLNEVS 5555

Query: 685  LSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS 744
            L + L            S      L  MN +W R  +   E    LQ   +  + F    
Sbjct: 5556 LKLPL------------SDVAVKTLQNMNRQWIRATATALERCSELQGIGLN-EKFLYCC 5602

Query: 745  HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
               + +LE I+    E + +D       L +  K    ++ E+  +Q    S    S QL
Sbjct: 5603 EKWIQLLEKIE----EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQL 5658

Query: 805  LVNAE 809
            L   E
Sbjct: 5659 LDTTE 5663



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 65/322 (20%), Positives = 128/322 (39%), Gaps = 27/322 (8%)

Query: 549  PELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGVI 603
            PEL    K Y  L  E S +    DS      +L +  E E+ P F+      T+ + + 
Sbjct: 5625 PELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI------TEFSKLT 5678

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            DRW+        ++  +   +++WQ F + + +++ +L DT   L  ++  E  +  QT 
Sbjct: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTR 5738

Query: 664  ELQIKKLKELQKAVDHRK-AIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
             L I +LK  +     R+    L++          D K    +  R+SQ+   W  +   
Sbjct: 5739 SL-IHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQ 5797

Query: 723  LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQ--- 779
            L E     Q  +       +    L   L+ +  +  + +P       E+ +D H +   
Sbjct: 5798 LAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLP-------ELHEDLHNEKEL 5850

Query: 780  LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
            + +++  L      +  LQ M   L  +    D +  KE++  +  + + L   V+   +
Sbjct: 5851 IKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQ 5910

Query: 840  ELEKLLDV----SSSQQDLSSW 857
            E+E  L+     +   ++L +W
Sbjct: 5911 EIEDRLNTWVVFNEKNKELCAW 5932



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 157/878 (17%), Positives = 353/878 (40%), Gaps = 133/878 (15%)

Query: 59   LRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
            L  W  ++E+       ++    EEI +++  +   Q ++E H+T   +   L EV    
Sbjct: 585  LACWATYVENLRLLRACFEETKKEEI-KEVPFETLAQWNLE-HATLNEAGNFLVEV---- 638

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMS-MERRLKIEETWRLWQKFLDDYSRFEDWL 177
                + D    SI +  R L++RWR + + + +E  L +    +    F +  +      
Sbjct: 639  ----SNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEE 694

Query: 178  K-----SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQ------VHECLTQLELINKQYR 226
            K     S++ +   P +        ++  K+ E F  Q      V + + Q+E+   + +
Sbjct: 695  KATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAK 754

Query: 227  RLARENRTDSAC--SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-------- 276
             +  ++  D++   SLK ++ +G+  +D L  R   +L+     I  +E F+        
Sbjct: 755  SVLDQDDVDTSMEESLKHLIAKGSM-FDELMARSEDMLQMDIQNISSQESFQHVLTTGLQ 813

Query: 277  ----TARDSILVWLTEMDLQLTNIEHFS-ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 331
                 A++ + + + ++   L N+   S + D++ K+++    Q+E+     + +Q++ Q
Sbjct: 814  AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEES---QKELESYMMRAQQLLGQ 870

Query: 332  GEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDR---- 387
             E   E       A+I      L +Y + V   ++    + I++ L +   D+  +    
Sbjct: 871  RESPGELISKHKEALIISNTKSLAKYLKAV-EELKNNVTEDIKMSLEEKSRDVCAKWESL 929

Query: 388  --ELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPA--SVDSI 443
              EL L       D+    + +D++L  +   N    L +  R++   ++  A  S +  
Sbjct: 930  HHELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGC 988

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
              + +H  ++ R+L       LPS+  + Q +    L+      + ++  + E ++ L  
Sbjct: 989  LYQLNHHMEVLREL----CEELPSQ--KSQQEVKRLLKDYEQKIERLLKCASEIHMTLQP 1042

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLG 563
             A   TS +   + +   + G    ++ F   +++N   ++    P +  S    ++ L 
Sbjct: 1043 TA-GGTSKNEGTITTSENRGGDPHSEAPFA--KSDNQPSTEKAMEPTMKFSLASVLRPLQ 1099

Query: 564  E-------CSSSIDSVKR--------LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWEL 608
            E        S+SI+S+          LEH L+  +  +    +  S E +++        
Sbjct: 1100 EESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITS--DFSSEEDRSSSC------ 1151

Query: 609  LQAQALSKELRMKQNLQKWQQFN-------SDLNSIWAWL----GDTEEELEQLQRLELS 657
            LQA+    ++   +   +W++F        + +N I         DT +E E+  ++ L+
Sbjct: 1152 LQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLN 1211

Query: 658  TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT-QADSKESRDLQDRLSQMNGRW 716
            T ++++E  ++ +  ++KA         S+ LC  +      + +   L D         
Sbjct: 1212 TRMESLETALRLVLPVEKA---------SLLLCGSDLPLHKMAIQGFHLIDA-------- 1254

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            DR+   L   +  +   +  C    E  + +L           E+ P D +    I+  +
Sbjct: 1255 DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVL----------KELHPFDLHAMQNIILKY 1304

Query: 777  HKQLMQIKHELLESQLRVASLQD---------MSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
              Q   + H +  S+  + +L+D         +S + + +   +D   A+E    + N+ 
Sbjct: 1305 KTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKE 1364

Query: 828  KL--LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
                L+K+ ++H+ +  K+LD+S    +    +S + L
Sbjct: 1365 GEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENL 1402



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 122/674 (18%), Positives = 271/674 (40%), Gaps = 99/674 (14%)

Query: 26   DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 85
            DR+Q LL     ++ +++E    +   D++ + L   + H   E+ + ++    NS E +
Sbjct: 2020 DRYQTLL----RQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMV--LNSSEGK 2073

Query: 86   RKLNEQ-QELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN 144
              L E+ Q+++  I     G A +  + +         A  +E   +Q+   ++  +W N
Sbjct: 2074 MPLEERIQKIKEIILLKPEGDARIETIMKQ--------AESSEAPLVQKTLTDISNQWDN 2125

Query: 145  ICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGVIYTVAKEELK 202
               ++       E+     +K+L         L     ++ A F    G+     K +LK
Sbjct: 2126 TLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGL--QEKKAQLK 2183

Query: 203  KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 262
             ++ F ++  +  + L+ +  Q   L    +  S            + W  ++    S+L
Sbjct: 2184 IYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSF---------SEEPWLEIKHLHESLL 2234

Query: 263  RRLKHFIGQREEFETARDSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKA 313
            ++L+  +   +      DS  V +T+++  L N   E  S  D       V+ K+++L+ 
Sbjct: 2235 QQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQE 2294

Query: 314  FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI 373
             +  +SL    +++I+A  + + + +  +   II++++  L+  C++             
Sbjct: 2295 LENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQ--CKQ------------- 2339

Query: 374  RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSG 433
                 D E+ L+  + E+E               +S+L  + S+        P R +++ 
Sbjct: 2340 ----KDLENRLASAKQEMECCL------------NSILKSKRSTEKKGKFTLPGREKQAT 2383

Query: 434  RDTPASV-DSIPLE-WDHDYDLSRD--LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDV 489
             D   S  +S  +E  + D+++++D  +E AMS+ L    +E   + +          + 
Sbjct: 2384 SDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNAQESMKNTE---------DER 2434

Query: 490  MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGP 549
             + E     ++L          +   L +Q+     A+      ++QTE +  +KT TG 
Sbjct: 2435 KVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKP----LEQTECL--NKTETGA 2488

Query: 550  ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
             +       +  +G  +  +D++ +    LK+ +ES   +  L   +   A V    + L
Sbjct: 2489 LV-------LHNIGYSAQHLDNLLQALITLKKNKESQ--YCVLRDFQEYLAAVESSMKAL 2539

Query: 610  QAQALSKELRMKQN---LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 666
                 S ++    +   L K ++F + +      LG+ + + E L       D + +E Q
Sbjct: 2540 LTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQ 2599

Query: 667  IKKLKELQKAVDHR 680
            IK+L+   + V+ +
Sbjct: 2600 IKQLEHGWEQVEQQ 2613



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
           W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361

Query: 666 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 721
              +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
           L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459

Query: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 829
              ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517

Query: 830 LLKEVSRHIKELEKLLDVSSSQQ 852
           LL++  + I+E E L  + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 122/752 (16%), Positives = 279/752 (37%), Gaps = 88/752 (11%)

Query: 11   ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
            E+  + +   L +   +W  L+  +    +KL +  +      K ++ + +W+ ++E + 
Sbjct: 5020 ETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQT 5079

Query: 71   A-KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 129
            + +  V+   ++ +++  L + +E + +++ +   +   +N   + L  CD  +   E  
Sbjct: 5080 SDEDSVHSPSSASQVKHLLQKHKEFRMEMD-YKQWIVDFVNQSLLQLSTCDVESKRYERT 5138

Query: 130  SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 189
               +    ++R+W  +  M   +   +E+      +  +      +WL++ E        
Sbjct: 5139 EFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQK 5198

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
               + +V K  L           +   QL + +K    L +   T  + ++  ++ +   
Sbjct: 5199 PESVISVQKLLL--------DCQDIENQLAIKSKALDELKQSYLTLESGAV-PLLEDTAS 5249

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSIL-VW------LTEMDLQLTN----IEH 298
            R D L ++ +S+L        Q  + +T+  S+L  W        E+++        +EH
Sbjct: 5250 RIDELFQKRSSVLT-------QVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEH 5302

Query: 299  -----FSECDVQAKIKQLKAFQQEISLNH---NKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
                  S   ++ +++ L++ Q E   +     K++++I + + L     P  A IIEE+
Sbjct: 5303 SKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC----PSVAEIIEEK 5358

Query: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
                   CQ    R  + ++ +       D+   +   L+L  + + +      R     
Sbjct: 5359 -------CQNTHKRWTQVNQAIA------DQLQKAQSLLQLWKAYSNAHGEAAARLKQQE 5405

Query: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
               Q  +N+S+S              P ++  I  E  HD   +++     S  L    +
Sbjct: 5406 AKFQQLANISMS------GNNLAEILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ 5458

Query: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
              +      L G         P          E  +   + +   + SQ +  G  L+  
Sbjct: 5459 PAESSTHMLLPG---------PLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESL 5509

Query: 531  RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 590
            +  I   E  +        E   S+  ++  L   S  I+ +  +  KL   + ++    
Sbjct: 5510 KGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQ 5569

Query: 591  NLHSTETQ-TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
            N++    + TA  ++R   LQ   L++  +     +KW Q                E++E
Sbjct: 5570 NMNRQWIRATATALERCSELQGIGLNE--KFLYCCEKWIQL--------------LEKIE 5613

Query: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-DLQDR 708
            +  +++++  +  +  Q K  K L+  V   + I  S    S +       E+R +    
Sbjct: 5614 EALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE 5673

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 740
             S++  RW      + + +G +   + Q Q F
Sbjct: 5674 FSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDF 5705



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 57/288 (19%), Positives = 105/288 (36%), Gaps = 51/288 (17%)

Query: 605  RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE 664
            +W  +      K   ++Q L+   +  + +  +  WL   EE L+ LQ+ E    +Q + 
Sbjct: 5150 QWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLL 5209

Query: 665  LQIKKLKE----LQKAVDHRKAIILSINL-CSPEFTQADSKESRDLQDR---LSQMNGRW 716
            L  + ++       KA+D  K   L++     P      S+     Q R   L+Q+N   
Sbjct: 5210 LDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLK 5269

Query: 717  DRVCSLLEEWRGLLQ---------------------------------DALMQCQGFHEM 743
              + S+L+EW+   Q                                 + L   Q   E 
Sbjct: 5270 TSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAES 5329

Query: 744  SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 803
            S G    L+ +  +   + P  + +  E  Q+ HK+  Q+   + +   +  SL  +  +
Sbjct: 5330 SEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQL-WK 5388

Query: 804  LLVNAEGTDCLEAKEK---------VHVIGNRLKLLLKEVSRHIKELE 842
               NA G      K++         + + GN L  +L    + IKEL+
Sbjct: 5389 AYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 101/626 (16%), Positives = 245/626 (39%), Gaps = 105/626 (16%)

Query: 199  EELKKFEAFQRQVHECLT-----QLELINKQYRRLARE-------------NRTDSACSL 240
            E+ +K    Q Q  E  T     QLE I K Y +L  +             N+T++   +
Sbjct: 2431 EDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALV 2490

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
               +    Q  DNL + + ++ +  +       +F+   + +    + M   LT+ E   
Sbjct: 2491 LHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQ---EYLAAVESSMKALLTDKESLK 2547

Query: 301  --ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
                D    + ++K F   I    + +  +  + E L      +D  ++E ++ +L    
Sbjct: 2548 VGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGW 2607

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS-PQPSS 417
            ++V  ++++ +               S + +E ++   L +     +  D+ +S  Q   
Sbjct: 2608 EQVEQQIQKKY---------------SQQVVEYDEFTTLMN-----KVQDTEISLQQQQQ 2647

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD-LSRDLESAMSRALPSEDEEGQDDK 476
            +L L L  P   ER+G  +  ++ +      H +  L    E  M R    ++++  +D 
Sbjct: 2648 HLQLRLKSP--EERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLED- 2704

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQ 536
                    G++++             +   +     H   E+QI++      D R ++++
Sbjct: 2705 --------GINNL-------------KKQWETLEPLHLEAENQIKKC-----DIRNKMKE 2738

Query: 537  T----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV----KRLEHKLKEEEESLPG 588
            T    +N++    P+ P L       ++   +C  + D +    + +E   +E ++ +P 
Sbjct: 2739 TILWAKNLLGELNPSIPLLPDDILSQIR---KCKVTHDGILARQQSVESLAEEVKDKVPS 2795

Query: 589  FVNLHSTETQTA--GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 646
                  ++       + +++++L  ++  +  +++  L++   F + +      + ++E 
Sbjct: 2796 LTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESET 2855

Query: 647  EL-----EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
             +           EL     T+E   K+L+E+   +      + +I      + + +  E
Sbjct: 2856 LIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI------YEELNVFE 2909

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 761
               L+D+L  +  R +R+   ++     ++  +  C+ FHE +  L    ++I R  NE+
Sbjct: 2910 RLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQR--NEL 2967

Query: 762  VPIDSNLDAEILQDHHKQLMQIKHEL 787
            +     L+ E+ +   +++  +K  L
Sbjct: 2968 L-----LNQEVNKGVKEEIYNLKDRL 2988



 Score = 31.2 bits (69), Expect = 5.0
 Identities = 18/90 (20%), Positives = 44/90 (48%), Gaps = 2/90 (2%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
            S   + +E    LG++N +W  +  ++  +++ L++ L ++ + +  +  L  WL   E 
Sbjct: 5132 SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE 5191

Query: 69   ELAKPIVYDSCNSEEIQRKLNEQQELQRDI 98
             L      +S  S  +Q+ L + Q+++  +
Sbjct: 5192 RLKTLQKPESVIS--VQKLLLDCQDIENQL 5219


>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform
           4 [Homo sapiens]
          Length = 556

 Score =  363 bits (932), Expect = e-100
 Identities = 241/608 (39%), Positives = 330/608 (54%), Gaps = 70/608 (11%)

Query: 391 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 450
           +ED   +    W  R      S +PSS  SL        ERSG +TP SVDSIPLEWDH 
Sbjct: 1   MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56

Query: 451 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTS 510
            D+          +   EDEEG     +Y      LSDV IPE+PEAY+K+T   +K +S
Sbjct: 57  GDVG-------GSSSHEEDEEGP----YYS----ALSDVEIPENPEAYLKMTTKTLKASS 101

Query: 511 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSS 567
           G  S  +     +  +        +Q E   R+  P  P   T YK   G + L      
Sbjct: 102 GK-SISDGHSWHVPDSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDG 159

Query: 568 SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW 627
             +  + L    ++E+  L G         Q +G  DRWE++QAQ L  +L++KQNLQ  
Sbjct: 160 GKEGPRVLNGNPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ-- 211

Query: 628 QQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI 687
            Q NSD+++I  WL  TE ELE L+  +  +DIQ IEL++K+L+E+ KA D  KA+++S+
Sbjct: 212 -QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSV 270

Query: 688 NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG-------- 739
           N+ S EF Q +S ES +LQ RL Q++  W+     ++ WRG L+ +LMQCQG        
Sbjct: 271 NVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 330

Query: 740 ------FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 793
                 FH++S  LLL L +   R+ +    D   D   L +  ++LMQ++ EL+E Q +
Sbjct: 331 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390

Query: 794 VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
           V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L ++VS      + L+ +  +Q  
Sbjct: 391 VDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNP 444

Query: 854 LSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSL 913
            S   S DE+D SG   P +    P R K  R                 R+T+G  ++  
Sbjct: 445 ASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------------VRTTEGEEETES 487

Query: 914 SEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPML 973
             PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC  +NNFARSF+PML
Sbjct: 488 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 547

Query: 974 RYTNGPPP 981
           RYTNGPPP
Sbjct: 548 RYTNGPPP 555



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)

Query: 26  DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 80
           DRW+ +         K+K+ L   QQL+ ++S++ TWL   E+EL     AKP      +
Sbjct: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242

Query: 81  SEEIQRKLNEQQELQRDIEKHSTGVASV 108
            +EI+ ++   QE+ +  + +   V SV
Sbjct: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270


>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform
           2 [Homo sapiens]
          Length = 429

 Score =  309 bits (791), Expect = 9e-84
 Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)

Query: 542 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 598
           R+  P  P   T YK   G + L        +  + L    ++E+  L G         Q
Sbjct: 5   RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58

Query: 599 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 658
            +G  DRWE++QAQ L  +L++KQNLQ   Q NSD+++I  WL  TE ELE L+  +  +
Sbjct: 59  QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115

Query: 659 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718
           DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W+ 
Sbjct: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175

Query: 719 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 764
               ++ WRG L+ +LMQCQG              FH++S  LLL L +   R+ +    
Sbjct: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235

Query: 765 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 824
           D   D   L +  ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI 
Sbjct: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295

Query: 825 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 884
            +LK L ++VS+ +  L+       +Q   S   S DE+D SG   P +           
Sbjct: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337

Query: 885 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 944
                 S P P       R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+
Sbjct: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391

Query: 945 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 981
            LACL+P SEEDYSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)

Query: 26  DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 80
           DRW+ +         K+K+ L   QQL+ ++S++ TWL   E+EL     AKP      +
Sbjct: 64  DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116

Query: 81  SEEIQRKLNEQQELQRDIEKHSTGVASV 108
            +EI+ ++   QE+ +  + +   V SV
Sbjct: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  126 bits (316), Expect = 1e-28
 Identities = 163/868 (18%), Positives = 352/868 (40%), Gaps = 63/868 (7%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q    + ++ 
Sbjct: 4164 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVF 4223

Query: 61   TWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
             W+     +LA   PI  D    E +++++ E ++ + +  +    +  + +  E+LL  
Sbjct: 4224 DWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK 4280

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                  +++  ++Q     L   W ++    + R+ K+E       +F         WL 
Sbjct: 4281 V---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLT 4337

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   +     G      + EL K    Q  V    + +E +NK    L   +  + A 
Sbjct: 4338 HTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEAS 4397

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
            +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ +  L   + 
Sbjct: 4398 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4457

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEELDELR 355
                   AK +QL    +  +    K E    ++ +G+Q++ +        I+++++ L+
Sbjct: 4458 LGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4516

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL-LSPQ 414
               + V                   E  L++R+ +LE++  L+ + +H+   D +    Q
Sbjct: 4517 EKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFINWLTQ 4556

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
                L+++    L            +D++  + D     + ++ S   + +   D+ G  
Sbjct: 4557 AEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQII-ELDKTGTH 4604

Query: 475  DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
             K F  +  V L   ++      + K+ +  ++       A   + +Q  +A       +
Sbjct: 4605 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAWSKLMEWL 4663

Query: 535  QQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 588
            +++E  + S+     + D        +K + K LG   S  D+  R    LKE+      
Sbjct: 4664 EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADD 4723

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 648
             + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL   E +L
Sbjct: 4724 NLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4780

Query: 649  EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
             + Q   +  DI  +   I   K  QK +  R + + ++   + E  +    +S  ++ +
Sbjct: 4781 AEDQ--PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4838

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDS 766
            + +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R + ++P D 
Sbjct: 4839 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4898

Query: 767  NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 826
            +     L D HK+ M+   +L E +  +     M   +L           K  + +I  R
Sbjct: 4899 DA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4954

Query: 827  LKLLLKEVSRHIKELEKLLDVSSSQQDL 854
             + +L    +H + L   L    ++Q+L
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQEL 4982



 Score =  120 bits (301), Expect = 6e-27
 Identities = 169/880 (19%), Positives = 375/880 (42%), Gaps = 101/880 (11%)

Query: 1    MGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            +G+ L +++ +S +++ +E+ L  VN RW+ L   +A R  +L+E L+   +    + SL
Sbjct: 3288 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3347

Query: 60   RTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
             +W+   E  +A  KP    S   + ++ ++ EQ+ LQR ++   + V       EV+  
Sbjct: 3348 LSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKR 3397

Query: 118  DCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
            + +  AT AE  D ++  +    LD RW  +   +  R  ++E    + Q+F +      
Sbjct: 3398 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3457

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINKQYRRLARE 231
            +WL + E+        G   +  +E++ + +A +  +   ++ L Q   I +  + L+  
Sbjct: 3458 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR 3517

Query: 232  NRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
               D    + Q   + +Q W   +Q++  S    L+  +   + F      ++ WL E+ 
Sbjct: 3518 EDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3573

Query: 291  LQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
             +L+  +++ +S   +  +  +L+  Q++I L    ++Q +  G +L++++   +  II+
Sbjct: 3574 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3633

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-----WH 403
            ++L+ ++   +++               L  D     ++ L+L  +  L   H     W 
Sbjct: 3634 DKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHSTHEELCTWL 3678

Query: 404  DRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            D+    LLS +         S +  +P   ++  ++  A +DS+            ++ S
Sbjct: 3679 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-----------NEVSS 3727

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
            A+   +P    EG +               M+ E  E Y +L  + I     +  A   +
Sbjct: 3728 ALLELVPWRAREGLEK--------------MVAEDNERY-RLVSDTITQKVEEIDAAILR 3772

Query: 520  IRQLGKALDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSV 572
             +Q  +A D     I +TE  + S       +  T  +L       M++L      ID +
Sbjct: 3773 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDL 3831

Query: 573  KRLEHKL----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQ 628
             +  HK+     EEE+         S + +   V+  ++ +      + L++++      
Sbjct: 3832 VKSGHKIMTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3883

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            QF      +W WL +T+  + QL    L  + +T+  Q ++ ++L++ +   K  I  +N
Sbjct: 3884 QFWETYEELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMN 3941

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
               P+  +    E   +Q++    +  + ++   +++    L +A+ Q   FH+    +L
Sbjct: 3942 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4001

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              LE I  R  +  P   + + E +++   +   +  ++ + Q    +L+    +++  +
Sbjct: 4002 ESLERIVERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4059

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 847
             GTD   + + V    +++  + + +   ++E E KLLDV
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4099



 Score =  104 bits (260), Expect = 4e-22
 Identities = 179/900 (19%), Positives = 361/900 (40%), Gaps = 106/900 (11%)

Query: 39   VKKLKETLVAVQ-QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 94
            +K+ KE + + Q QLD     + SL++W+     ++  PIV  S  +E++ + L + ++L
Sbjct: 2303 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKL 2360

Query: 95   QR-------DIEKHSTGVASVLNLCEVLLHDCDACA---------------TDAE----- 127
            Q        +I+K +    S+ NL   +     A A               T+ E     
Sbjct: 2361 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2420

Query: 128  --CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
                SI++   ++   + ++  +  ++  ++       QK  ++ S    WL+   +TA 
Sbjct: 2421 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2480

Query: 186  -FPSSSGVIYTVA-KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQ 242
             +  +     T A K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQ
Sbjct: 2481 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2540

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 302
            M+ E + +W  L +      ++L+       +F+T    +  WL E +L ++ +   S  
Sbjct: 2541 MLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSID 2600

Query: 303  D--VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYC 358
               +  + +Q++   QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +  
Sbjct: 2601 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2660

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
              + G++      + +  +   ++    R L    S  LSDL     S+ ++ +   + N
Sbjct: 2661 DSLTGQLSDRCDWIDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMN 2716

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDK 476
              L  AQ ++ E         V     E     DLS  ++    +A  S   EG  +  K
Sbjct: 2717 QQLETAQKMKQEIQQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFK 2771

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQ 533
            D             + +  E +V+  ++A         A   Q +Q+ +      D++ +
Sbjct: 2772 D-------------VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKE 2810

Query: 534  IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNL 592
             Q   + I +K      L   +K + K L   S   + ++   E+ L + + S    + L
Sbjct: 2811 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2870

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +T      W+    Q   +E ++K++L+K  ++   + ++W W+   +  LE+  
Sbjct: 2871 QLNTIKT-----NWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-- 2923

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             ++   D    E  I KLK LQK +D    ++  +N  +         +   + D    +
Sbjct: 2924 -IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSL 2982

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNL 768
              + D V   L   +  L++   + + F E+S      L    E +D   +      SN 
Sbjct: 2983 IQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3042

Query: 769  DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
               +LQ   K L  +KH++    L     QD+  +   +++GT   +   +V  I     
Sbjct: 3043 YLTMLQTQQKSLQALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHS 3096

Query: 829  LLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 882
             L ++V      LE KL  +   Q  +    S      DELD+   V    GR     QK
Sbjct: 3097 TLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3152



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 166/889 (18%), Positives = 342/889 (38%), Gaps = 95/889 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES----ELA 71
            E++ KL    DR++ L          LK+ +   Q  +     L   L   E+     L+
Sbjct: 1956 EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS 2015

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +PI  D  N   +QR+L E + LQ  I      V  +    EVLL D       A+ D I
Sbjct: 2016 EPIAVDPKN---LQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-DARGSLLPAKND-I 2070

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 191
            Q+   ++  R+ ++     ER  K++ T        D      DW+ + E +        
Sbjct: 2071 QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVP 2130

Query: 192  VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRW 251
            +  T  ++ + K    ++ +    + +  +N++ ++        +A SL+  + + + R+
Sbjct: 2131 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARF 2190

Query: 252  DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-IKQ 310
                 +    L +++    + E FE   + +  +L       T  +  +E DV  K + +
Sbjct: 2191 SEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE------TKTQALTEVDVPGKDVTE 2244

Query: 311  LKAFQQEIS---LNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRR---------- 356
            L  + QE +   L H K +E + +  +++     P D A++ E+ + L +          
Sbjct: 2245 LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK 2304

Query: 357  -------YCQEVFGRVERYHKKL--------IRLPLPDDEHDLSDRELELEDSAALSDLH 401
                    CQE     +   K L         ++P+        D    LED+  L +  
Sbjct: 2305 EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE-K 2363

Query: 402  WHDRSADSLLSP--QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            W      SL +P  Q  +N  +SL   + +  +     A+V S     + +   +   E 
Sbjct: 2364 W------SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2417

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
              ++ L S  ++  D    Y    + L D           K+ E            L ++
Sbjct: 2418 WANKGLTSIKKDMTDISHGYEDLGLLLKD-----------KIAE------------LNTK 2454

Query: 520  IRQLGKALDDSRFQIQQTENIIRSKT-------PTGPE-LDTSYKGYMKLLGECSSSIDS 571
            + +L KA ++S   +Q  + + ++ T       PT  E + T  +       E   +++ 
Sbjct: 2455 LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2514

Query: 572  VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFN 631
            V+ L+ KL E  E  P        +     +  +W+ L    + ++ +++++     QF 
Sbjct: 2515 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2574

Query: 632  SDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCS 691
            +    +  WL   E+EL       LS D   +  Q ++++ L +    RK     +    
Sbjct: 2575 TVEAQLKQWL--VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2632

Query: 692  PEFTQADSKESR---DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                    ++      ++++L+ +  +WD +   L +    +  A+++   +  +   L 
Sbjct: 2633 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2692

Query: 749  LMLENIDRRKNEIVPIDSNLDA--EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV 806
              L ++D + +  + + ++ DA  + L+   K   +I+ E  + ++  A  +D+S   LV
Sbjct: 2693 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA--LV 2750

Query: 807  NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 855
              E     E   ++  I    K + ++   H++ L+     S   Q +S
Sbjct: 2751 KEEYLKA-ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2798



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 158/857 (18%), Positives = 337/857 (39%), Gaps = 75/857 (8%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES--ELAKPI 74
            I+  L  ++ +   LLD   AR ++++ T+  +++    +      L   E   E   P+
Sbjct: 3194 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV 3253

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
                  +E I ++LN  +  Q++  +   G    +N     L    A +T  +   ++  
Sbjct: 3254 ---GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHD 3308

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 194
              +++ RW+ +     +R  +++E      +F D       W+  +E   A        +
Sbjct: 3309 LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF 3368

Query: 195  TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 254
             V K ++++ +  QR + +  + +E+I ++  ++A          + + +   + RW+ L
Sbjct: 3369 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3428

Query: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLK 312
              +  +  R+L+      ++F    + +  WLT ++ +L N E        ++ +I Q K
Sbjct: 3429 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3488

Query: 313  AFQQEISLNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV----FGRVER 367
            A + +I +NHNK + Q ++ G+ L   S   D  +++ +LD  + +  E+      R E 
Sbjct: 3489 ALEDDI-INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3547

Query: 368  YHKKLIRLPL-PDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
              + L    +  +DE +L +   E+ D   LS L   D S + L   Q    +       
Sbjct: 3548 LQQALCNAKIFGEDEVELMNWLNEVHDK--LSKLSVQDYSTEGLWKQQSELRV------- 3598

Query: 427  LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
                          D +  + + D  L   LE                     L+   G 
Sbjct: 3599 -----------LQEDILLRKQNVDQALLNGLE--------------------LLKQTTGD 3627

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-----QQTENII 541
              ++I +  EA +K     I   S D +    Q  QL + L  +  ++     +    ++
Sbjct: 3628 EVLIIQDKLEA-IKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELL 3686

Query: 542  RSKTPT--GPELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              +T    G E   +     +L  E  ++   +DS+  +   L E    L  +      E
Sbjct: 3687 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE----LVPWRAREGLE 3742

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
               A   +R+ L+      K   +   + + QQF+   ++  +W+ +TE++L  L  + L
Sbjct: 3743 KMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3802

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
              D  + +LQ++K   ++  + H+  I   +       T    +E + ++ +L ++   +
Sbjct: 3803 EQDQTSAQLQVQKTFTME-ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3861

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            D +C +  E    L+ A      F E    L   L       +++ P  + L+ E L+  
Sbjct: 3862 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL-PAPA-LEYETLRQQ 3919

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++  Q++  + E +  +  +     QLL  + G +    +EK          + ++V +
Sbjct: 3920 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG-EGFSIQEKYVAADTLYSQIKEDVKK 3978

Query: 837  HIKELEKLLDVSSSQQD 853
                L++ +  S+   D
Sbjct: 3979 RAVALDEAISQSTQFHD 3995



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 152/877 (17%), Positives = 347/877 (39%), Gaps = 83/877 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE++A  +  +   +I  +L  ++ RW+ LL+    R ++L+   V  QQ  + +  L  
Sbjct: 3399 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3458

Query: 62   WLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            WL  IE  L   +PI      + +++ ++ + + L+ DI  H+  +   +++ + L    
Sbjct: 3459 WLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL---- 3511

Query: 120  DACATDAECDSIQQATRNLDRRWR-NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                +  E   + Q+  +  + W   I   S  R   +++     + F +D     +WL 
Sbjct: 3512 -KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3570

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY--------RRLAR 230
                  +  S    +   + E L K ++  R + E +    L+ KQ           L +
Sbjct: 3571 EVHDKLSKLS----VQDYSTEGLWKQQSELRVLQEDI----LLRKQNVDQALLNGLELLK 3622

Query: 231  ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
            +   D    ++  +     R+ ++ K  T + + L+  +       +  + +  WL +++
Sbjct: 3623 QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE 3682

Query: 291  LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
            ++L + E       +A   Q++  + +    +NK          L++    + +A++E  
Sbjct: 3683 VELLSYETQVLKGEEASQAQMRPKELKKEAKNNK---------ALLDSLNEVSSALLELV 3733

Query: 351  LDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADS 409
                R   +++     ERY  +L+         D   +++E  D+A L    + D++AD+
Sbjct: 3734 PWRAREGLEKMVAEDNERY--RLV--------SDTITQKVEEIDAAILRSQQF-DQAADA 3782

Query: 410  LLSPQPSSNLSLSLAQPLRSERSGRDTPASVD-SIPLEWDHDYDLSRDLESAMSRALPSE 468
             LS    +   L     +R E+        V  +  +E     D+  DL  +  + + + 
Sbjct: 3783 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3842

Query: 469  DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD 528
             EE +      L   +   D +   + E Y++L               +S + Q  +  +
Sbjct: 3843 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQL------------ERAQSLVNQFWETYE 3890

Query: 529  DSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +    + +T++II        E +T       ++   +L+ E    ID + +   +L E 
Sbjct: 3891 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3950

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                 GF    S + +       +  ++     + + + + + +  QF+  ++ I   L 
Sbjct: 3951 SPG-EGF----SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LE 4002

Query: 643  DTEEELEQL-QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
              E  +E+L Q   +S +++ I+ QI + K +   ++  + +  ++     E        
Sbjct: 4003 SLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 4062

Query: 702  SRDL-----QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
             +D+     QD+L QM   W+ + +L+EE    L D +   + F      L++ +++   
Sbjct: 4063 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 4122

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
               ++   D  +D  +++   +    I+ E+   Q  +  + ++  +L+      D    
Sbjct: 4123 FIRDLE--DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4180

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
            K+ +  + +    L K     I +LE+ +  +   QD
Sbjct: 4181 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4217



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 73/379 (19%), Positives = 169/379 (44%), Gaps = 17/379 (4%)

Query: 3    ERLAKASHESK---ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            E +A++    K   A  ++ KL ++   W+++  L+  R  KL + +   ++   +  SL
Sbjct: 4054 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4113

Query: 60   RTWLAHIES---ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 116
               +   +    +L  P +  S         + +QQE    I +   G+   L++   L 
Sbjct: 4114 IVTIKDTQDFIRDLEDPGIDPSV--------VKQQQEAAETIREEIDGLQEELDIVINLG 4165

Query: 117  HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 176
             +  A   + +   ++++   L+  W ++     +R  K+EE  +   ++ D      DW
Sbjct: 4166 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4225

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            +  +    A  S  G      K+++++ + F+ + ++   ++E +N Q   L ++   +S
Sbjct: 4226 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEES 4285

Query: 237  -ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
               +++  + E    WD+L++R+ +   +L+  +    +F+ A D +L WLT  +  L+ 
Sbjct: 4286 DKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE 4345

Query: 296  IEHFSECDVQAKIKQLK--AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             +         +I+  K    Q ++  + + +E +   G  LIE S   +A+ ++ +L+ 
Sbjct: 4346 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEV 4405

Query: 354  LRRYCQEVFGRVERYHKKL 372
            L +  Q V  + E+  ++L
Sbjct: 4406 LNQRWQNVLEKTEQRKQQL 4424



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 168/922 (18%), Positives = 348/922 (37%), Gaps = 106/922 (11%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L   +  S+ + ++ +L  +   W      +  R  KLKE+L    +  + + +L  
Sbjct: 2853 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 2912

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD- 120
            W+   ++ L +  +    +  E +  + + + LQ+++++H   V  + N    LL  C+ 
Sbjct: 2913 WIDKCQNNLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2970

Query: 121  --ACATDAECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDW 176
                 TD     IQ+     ++   +  C  +M ++ K  +E  +  ++ L       D 
Sbjct: 2971 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3029

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLT 216
            +  S  + A+   S    T+ + + K  +A + QV                     + L 
Sbjct: 3030 IHDSLGSQAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3086

Query: 217  QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE 276
            Q+E I +++  L+++   D  CS  +   +G   + N           ++    Q  EF+
Sbjct: 3087 QVETIAQEHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFD 3134

Query: 277  TARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLI 336
               DS    +  +      ++   E  ++A +K+L+A        +   + ++A      
Sbjct: 3135 DELDS----MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----T 3184

Query: 337  EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 396
            E++ P D   I+ +L+ L + C ++  R +   +++       +E     +E     S  
Sbjct: 3185 EETSP-DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SIL 3239

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
            L     H+ S   +     + N  L++ +  + E      P       + W     L + 
Sbjct: 3240 LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQG 3291

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
            L  + +++  ++  E              L DV       A  K     +   +      
Sbjct: 3292 LIQSAAKSTSTQGLEHD------------LDDV------NARWKTLNKKVAQRAAQLQEA 3333

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSID 570
                 +   AL+     +  TE ++ ++ P   E           K   +LL +  S+++
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3393

Query: 571  SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 630
             +KR   K+    E       L     Q + +  RWE L  +A ++  +++      QQF
Sbjct: 3394 VIKREGEKIATTAEPADKVKIL----KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3449

Query: 631  NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINL 689
            +  L  +  WL   E+ L   +   + T    +E QI + K L+   ++H K +  ++++
Sbjct: 3450 HETLEPLNEWLTTIEKRLVNCE--PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI 3507

Query: 690  CSPEFTQADSKESRDL-QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                     S+E +D+ Q +L      +  +         LLQ AL   + F E    L+
Sbjct: 3508 -GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3566

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              L  +  + +++   D     E L     +L  ++ ++L  +  V        +LL   
Sbjct: 3567 NWLNEVHDKLSKLSVQD--YSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3624

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADELD 864
             G + L  ++K+  I  R K + K  +   K LE+ L ++    S+ ++L +W    E++
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684

Query: 865  -TSGSVSPTSGRSTPNRQKTPR 885
              S       G      Q  P+
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPK 3706



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 162/881 (18%), Positives = 342/881 (38%), Gaps = 71/881 (8%)

Query: 6    AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 65
            A+ S     ++I+  L  +  R++ L   +  R +KL+ TL     +   +  +  W+ +
Sbjct: 2059 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2118

Query: 66   IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            +ES L K       NS  +Q  +++   L++DI    + + ++    +  +   D     
Sbjct: 2119 VESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD----P 2173

Query: 126  AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            +   S+Q   ++L  R+        E   K+EE     + F +   + + +L++  +   
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2233

Query: 186  FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                 G   T   + +++  +   +  E    LE+++   + ++          + +  +
Sbjct: 2234 EVDVPGKDVTELSQYMQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTN 2290

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDV 304
              ++++  ++  +      +     Q + F+    S+  W+ E   ++  ++  F   D+
Sbjct: 2291 NLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDL 2350

Query: 305  QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE----KSEPLDAAIIEEELDELRRYCQE 360
               ++  K  Q++ SL   +I+++   G  L       + P  A    +    +      
Sbjct: 2351 GKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGT 2410

Query: 361  VFGRVERYHKK---LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
                 E +  K    I+  + D  H   D  L L+D  A      + + +    + + SS
Sbjct: 2411 ATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA----ELNTKLSKLQKAQEESS 2466

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
             +   L +  ++    + TPA  D+  ++   + + S + E      L     + Q+ KD
Sbjct: 2467 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE------LKQNVNKVQELKD 2520

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ---- 533
                      D   PE+P     LTE   K    +   ++ Q +    + + ++FQ    
Sbjct: 2521 KLTELLEENPDT--PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2578

Query: 534  -----IQQTENIIRSKTPTGPE---LDTSYKGYMKLLGECSSSIDSVKRLEH------KL 579
                 + + E ++    P   +   L+T  +    LL E ++     ++L          
Sbjct: 2579 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2638

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
              E+ SL G V     + Q A V  +W+ L  Q   +   + Q + K  Q+ S L S+  
Sbjct: 2639 PGEDPSLRGIV-----KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2693

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV-DHRKAIILSINLCSPEFTQAD 698
             L D + +L     L +ST    +  Q++  +++++ +   +K I ++  LC  E   A 
Sbjct: 2694 KLSDLDNKLS--SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC--EDLSAL 2749

Query: 699  SKE---SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
             KE     +L  +L  +   +  V    E     LQ A      F +MS      L+   
Sbjct: 2750 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2809

Query: 756  RRKNEIVPIDSNLDA--EILQDH---HKQLMQIKH----ELLESQ---LRVASLQDMSCQ 803
              +N+  PI + LD    +++DH    K L    H     + E +   L+    +  + Q
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2869

Query: 804  LLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 844
            L +N   T+     ++V    N+LK  L++  ++ +++E L
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2910



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 162/891 (18%), Positives = 354/891 (39%), Gaps = 104/891 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            K  ++ +RWQ++   I  R++ L+    +++        L  W+  +E+   K       
Sbjct: 1292 KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 1351

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            NS+ +  +LN+Q+ L  +IE       S ++ C+       A   D E  ++      +D
Sbjct: 1352 NSKTLATQLNQQKMLVSEIEMKQ----SKMDECQKYAEQYSATVKDYELQTMTYRAM-VD 1406

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             + ++     ++RR        + Q+F+D  +R+   +    +   F   S  +  + +E
Sbjct: 1407 SQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEE 1460

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVT 259
            E    E  +  V +     + ++   + L    +       KQ +   ++     +++++
Sbjct: 1461 EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI--SSEEISTKKEQLS 1518

Query: 260  SILRRLKHFIG---------QREEFE----TARDSILVWLTEMDLQLTNIEHFSECDVQA 306
              L+ ++ F+          +R E E    T ++S  +  +E   QL   +   +  V+ 
Sbjct: 1519 EALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEE 1578

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC--QEVFGR 364
            KI   +  QQE       I  ++ Q E  +   +  +A +I +   EL++Y   QE   +
Sbjct: 1579 KIVAER--QQEYKEKLQGICDLLTQTENRLIGHQ--EAFMIGDGTVELKKYQSKQEELQK 1634

Query: 365  VERYHKKLIRLPLPDDEHDLSDRELEL-EDSAALSDLHWHDRSAD----SLLSPQPSSNL 419
              +   + +   + + E+ L +   +L ++  AL +   ++        +L + Q    L
Sbjct: 1635 DMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL 1694

Query: 420  SLSLAQPLRSE-------RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
               +   ++ E       +   ++   ++++ L+W  + D  +D E A ++     ++ G
Sbjct: 1695 DKVVTTAIKEETEKVAAVKQLEESKTKIENL-LDWLSNVD--KDSERAGTKHKQVIEQNG 1751

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRF 532
               ++   + A+G       E  E    L E  +    G      +Q  Q  KA      
Sbjct: 1752 THFQEGDGKSAIG-------EEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA------ 1798

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
               Q E II                   ++   S+ +   K+ ++   EE+E L   +  
Sbjct: 1799 ---QHEKIISQHQAV-------------IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1842

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +TA      ++    +L +EL         ++F++D      WL  +E+ELE L+
Sbjct: 1843 LKVHYETALAESEKKMKLTHSLQEEL---------EKFDADYTEFEHWLQQSEQELENLE 1893

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA-------------DS 699
                + DI  +  ++K+ K   + V   K  +  I +      +A              S
Sbjct: 1894 --AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTS 1951

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
               R++Q +L     R+  + S        L+D + + Q + + S GLL  L+  +   +
Sbjct: 1952 ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS 2011

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 819
            + +     +D + LQ   ++   ++ ++   Q+ V  L+  + ++L++A G+  L AK  
Sbjct: 2012 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK-KTAEVLLDARGS-LLPAKND 2069

Query: 820  VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE-LDTSGSV 869
            +    + +    +++S+ + E  + L ++ + + LS     DE LD  G+V
Sbjct: 2070 IQKTLDDIVGRYEDLSKSVNERNEKLQITLT-RSLSVQDGLDEMLDWMGNV 2119



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 188/971 (19%), Positives = 363/971 (37%), Gaps = 161/971 (16%)

Query: 43   KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 102
            KE +   ++L K +S++   L   E     P      +SEEI  K  +  E         
Sbjct: 1469 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--------- 1519

Query: 103  TGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR--------L 154
                  L   ++ L       TD E + +++  + L   +  + + S+++         +
Sbjct: 1520 -----ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1574

Query: 155  KIEE--TWRLWQKFLDDYSRFEDWLKSSERTA-----AFPSSSGVIYTVAKEELKKFEAF 207
            K+EE       Q++ +      D L  +E        AF    G +      ELKK+++ 
Sbjct: 1575 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV------ELKKYQSK 1628

Query: 208  QRQVH-------ECLTQL------------ELINKQYRRLARENRTDSACSLKQMVHEGN 248
            Q ++        + L ++            E ++++ + L  +   ++    +Q+  +  
Sbjct: 1629 QEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAE 1688

Query: 249  QRWDNLQKRVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLT----------- 294
            Q    L K VT+ ++     +    Q EE +T  +++L WL+ +D               
Sbjct: 1689 QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1748

Query: 295  -NIEHFSECDVQAKIK----------------QLKAFQQEISLNHNKI----EQIIAQ-- 331
             N  HF E D ++ I                 Q+   Q+ ++  + K+    E+II+Q  
Sbjct: 1749 QNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQ 1808

Query: 332  --------GEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD 379
                     + L+EK      P +   +++ + EL+ + +      E+  K         
Sbjct: 1809 AVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT------- 1861

Query: 380  DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 439
              H L + ELE  D+      HW  +S   L + +  ++    L   L+ ++S      S
Sbjct: 1862 --HSLQE-ELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS-----FS 1913

Query: 440  VDSIPLEWDHDYDL---SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
             D I  + D  Y     +R LE+A S    S+ + G+ D     R      D        
Sbjct: 1914 EDVISHKGDLRYITISGNRVLEAAKSC---SKRDGGKVDTSATHREVQRKLDHATDRFRS 1970

Query: 497  AYVK--LTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
             Y K  +  N +K+    +   E     L   L     +   ++++          L   
Sbjct: 1971 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC--EATASKHLSEPIAVDPKNLQRQ 2028

Query: 555  YKGYMKLLGECSSSIDSVKRL----EHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 610
             +    L G+ SS   +V++L    E  L      LP   ++  T     G   R+E L 
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG---RYEDLS 2085

Query: 611  AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL-STDIQTIELQIKK 669
                 +  +++  L +       L+ +  W+G+ E  L++  ++ L ST +Q I   I K
Sbjct: 2086 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISK 2142

Query: 670  LKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 728
               L++ +  R++ I ++N    +F +  D   +  LQ ++  ++ R+       +E   
Sbjct: 2143 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2202

Query: 729  LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI-VP-IDSNLDAEILQDHHKQLMQIKH- 785
             +++   + + F  +S  L   LE   +   E+ VP  D    ++ +Q+   + ++ K  
Sbjct: 2203 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 2262

Query: 786  -ELLESQLRVASLQDMSCQLLVNAEGTDCL------------EAKEKVHVIGNRL---KL 829
             E+L S L+  S   +     +  E T+ L            E KE V     +L   ++
Sbjct: 2263 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 2322

Query: 830  LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCS 889
            L+K +   IKE  K + +   Q    +      L+ +  +       TP  QK      S
Sbjct: 2323 LVKSLKSWIKETTKKVPI--VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2380

Query: 890  LSQPGPSVSSP 900
            L     +V++P
Sbjct: 2381 LCNLISAVTTP 2391



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 149/753 (19%), Positives = 298/753 (39%), Gaps = 117/753 (15%)

Query: 171  SRFEDWLKSSERTAAFPSSS--------GVIYTVAKEELKKFEAFQRQVHECLTQLELIN 222
            SRFED+L+ S+ +  F  S          V     +E LK  E  + +  E +  L +  
Sbjct: 1043 SRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE--REEQEESVYNLYISE 1100

Query: 223  KQYRRLARENRTDSACSLKQMVHEGNQRWDNL-----QKRVTSILRRLKHFIG----QRE 273
             +  RL  EN  D      +   E +   +++     Q+++   L RLK  +G    + E
Sbjct: 1101 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1160

Query: 274  EF---ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 330
            EF     A  S+    +E+++ L N+           I +LK     +  N    E ++ 
Sbjct: 1161 EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMS-STYIDKLKTVNLVLK-NTQAAEALVK 1218

Query: 331  QGEQLIEKSEPL--DAAIIEEELDELRRYCQEVFGRVERYH---KKLIRLPLPDDEHDLS 385
              E  + + E +  D   IE  +  L+++  EV  + + +H    +L +     DE   +
Sbjct: 1219 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1278

Query: 386  DRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS-ERSGRDTPASVDSI- 443
             +E +L       D  WH   AD L+  +   N+ + +   LR  E  G+      D+  
Sbjct: 1279 YKERDL-------DFDWHKEKADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1329

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            PL+     D  + +E+   +   ++ E  +       +  + +S++ + +S     +   
Sbjct: 1330 PLD-----DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1384

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDS---RFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
                 T  D+       R +  +   S   R ++Q + ++I  +     +L T Y   + 
Sbjct: 1385 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF---MDLRTRYTALVT 1441

Query: 561  LLGE-CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRW------ELLQAQA 613
            L+ +    + DS+KRLE    EEE+SL      H    + A  + +W       L  A+ 
Sbjct: 1442 LMTQYIKFAGDSLKRLE----EEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEK 1494

Query: 614  LSKELRMKQNLQ------KWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE--- 664
              K    KQ +       K +Q +  L +I  +L    +++   +R EL   ++T++   
Sbjct: 1495 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESY 1554

Query: 665  --LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCS 721
              L  + LK+LQ++                  T  D K E + + +R  +   +   +C 
Sbjct: 1555 NLLFSESLKQLQESQ-----------------TSGDVKVEEKIVAERQQEYKEKLQGICD 1597

Query: 722  LLEEWRG---------LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            LL +            ++ D  ++ + +      L   ++   +   E+V    N     
Sbjct: 1598 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN----F 1653

Query: 773  LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            L+++ ++L Q    L+E +L  A ++   C+ L        L+A++    +   +   +K
Sbjct: 1654 LKENGEKLSQEDKALIEQKLNEAKIK---CEQL-------NLKAEQSKKELDKVVTTAIK 1703

Query: 833  EVSRHIKELEKLLDVSSSQQDLSSWSSADELDT 865
            E +  +  +++L +  +  ++L  W S  + D+
Sbjct: 1704 EETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1736



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 119/677 (17%), Positives = 261/677 (38%), Gaps = 100/677 (14%)

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            D + D  ++    L  RW+N+      R   +E   +  + + D Y   +DW++  E T 
Sbjct: 1283 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1342

Query: 185  A-----FPSSSGVIYTVAKEE---LKKFEAFQRQVHEC----------LTQLELINKQYR 226
                   P +S  + T   ++   + + E  Q ++ EC          +   EL    YR
Sbjct: 1343 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1402

Query: 227  RLARENRTDSACSLKQMVHEGN---QRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 283
             +  +++  S    ++M    +   Q + +L+ R T+++  +  +I      + A DS+ 
Sbjct: 1403 AMV-DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI------KFAGDSL- 1454

Query: 284  VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 343
                    +L   E   E + +  +++ K  Q+ +S     ++     G+    K +   
Sbjct: 1455 -------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK--- 1504

Query: 344  AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 403
              I  EE+   +    E    ++ +  K       ++ ++L  +   L++S  L      
Sbjct: 1505 --ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL----LF 1558

Query: 404  DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD-----HDYDLSRDLE 458
              S   L   Q S ++ +        ++  ++    +  +  + +     H         
Sbjct: 1559 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1618

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
            +   +   S+ EE Q D       A  L++V+  ++ E ++K  EN  K +  D + +E 
Sbjct: 1619 TVELKKYQSKQEELQKDMQ---GSAQALAEVV--KNTENFLK--ENGEKLSQEDKALIEQ 1671

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++ +     +    + +Q++           ELD   K     + E +  + +VK+LE  
Sbjct: 1672 KLNEAKIKCEQLNLKAEQSKK----------ELD---KVVTTAIKEETEKVAAVKQLEES 1718

Query: 579  LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL--NS 636
             K + E+L  +++    +++ AG   +  + Q     +E   K  + +  + N +L    
Sbjct: 1719 -KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1777

Query: 637  IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKAIILSIN----LCS 691
            +   +G T+E L Q               Q +K+K + +K +   +A+I++      L  
Sbjct: 1778 VDGQVGTTQENLNQ---------------QYQKVKAQHEKIISQHQAVIIATQSAQVLLE 1822

Query: 692  PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL---LQDALMQCQG-FHEMSHGL 747
             +      +E   LQ  + ++   ++   +  E+   L   LQ+ L +    + E  H L
Sbjct: 1823 KQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWL 1882

Query: 748  LLM---LENIDRRKNEI 761
                  LEN++   ++I
Sbjct: 1883 QQSEQELENLEAGADDI 1899



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 61/327 (18%), Positives = 134/327 (40%), Gaps = 36/327 (11%)

Query: 499 VKLTENAIKNTSGDHSALESQI-----RQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 553
           +++ +  +K++  D +  E +I     + L   +D+ + Q+ +TE    S  P+      
Sbjct: 611 MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE--WGSDLPSVESHLE 668

Query: 554 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 613
           ++K   + + E  SS+      E K+ E + + P        +   A  + R E   A+ 
Sbjct: 669 NHKNVHRAIEEFESSLK-----EAKISEIQMTAP-------LKLTYAEKLHRLESQYAKL 716

Query: 614 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-- 671
           L+     +++L     F S   +   WL + EEE       E++ D       I + K  
Sbjct: 717 LNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE-------EVAYDWSERNTNIARKKDY 769

Query: 672 --ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 729
             EL + +D ++  I S+   + +    +      ++   + M  +W  +  L +     
Sbjct: 770 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 829

Query: 730 LQDALMQCQGFHEMSHG--LLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 787
           +++     + F++       L  L++  +RK      D +     L+D  ++ M+ K EL
Sbjct: 830 IKENTAYFEFFNDAKEATDYLRNLKDAIQRK---YSCDRSSSIHKLEDLVQESMEEKEEL 886

Query: 788 LESQLRVASLQDMSCQLL-VNAEGTDC 813
           L+ +  +A+L   +  ++ +    +DC
Sbjct: 887 LQYKSTIANLMGKAKTIIQLKPRNSDC 913


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  126 bits (316), Expect = 1e-28
 Identities = 163/868 (18%), Positives = 352/868 (40%), Gaps = 63/868 (7%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q    + ++ 
Sbjct: 4175 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVF 4234

Query: 61   TWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
             W+     +LA   PI  D    E +++++ E ++ + +  +    +  + +  E+LL  
Sbjct: 4235 DWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK 4291

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                  +++  ++Q     L   W ++    + R+ K+E       +F         WL 
Sbjct: 4292 V---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLT 4348

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   +     G      + EL K    Q  V    + +E +NK    L   +  + A 
Sbjct: 4349 HTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEAS 4408

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
            +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ +  L   + 
Sbjct: 4409 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4468

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEELDELR 355
                   AK +QL    +  +    K E    ++ +G+Q++ +        I+++++ L+
Sbjct: 4469 LGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4527

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL-LSPQ 414
               + V                   E  L++R+ +LE++  L+ + +H+   D +    Q
Sbjct: 4528 EKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFINWLTQ 4567

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
                L+++    L            +D++  + D     + ++ S   + +   D+ G  
Sbjct: 4568 AEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQII-ELDKTGTH 4615

Query: 475  DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
             K F  +  V L   ++      + K+ +  ++       A   + +Q  +A       +
Sbjct: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAWSKLMEWL 4674

Query: 535  QQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 588
            +++E  + S+     + D        +K + K LG   S  D+  R    LKE+      
Sbjct: 4675 EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADD 4734

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 648
             + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL   E +L
Sbjct: 4735 NLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4791

Query: 649  EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
             + Q   +  DI  +   I   K  QK +  R + + ++   + E  +    +S  ++ +
Sbjct: 4792 AEDQ--PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4849

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDS 766
            + +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R + ++P D 
Sbjct: 4850 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4909

Query: 767  NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 826
            +     L D HK+ M+   +L E +  +     M   +L           K  + +I  R
Sbjct: 4910 DA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965

Query: 827  LKLLLKEVSRHIKELEKLLDVSSSQQDL 854
             + +L    +H + L   L    ++Q+L
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQEL 4993



 Score =  120 bits (301), Expect = 6e-27
 Identities = 169/880 (19%), Positives = 375/880 (42%), Gaps = 101/880 (11%)

Query: 1    MGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            +G+ L +++ +S +++ +E+ L  VN RW+ L   +A R  +L+E L+   +    + SL
Sbjct: 3299 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3358

Query: 60   RTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
             +W+   E  +A  KP    S   + ++ ++ EQ+ LQR ++   + V       EV+  
Sbjct: 3359 LSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKR 3408

Query: 118  DCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
            + +  AT AE  D ++  +    LD RW  +   +  R  ++E    + Q+F +      
Sbjct: 3409 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3468

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINKQYRRLARE 231
            +WL + E+        G   +  +E++ + +A +  +   ++ L Q   I +  + L+  
Sbjct: 3469 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR 3528

Query: 232  NRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
               D    + Q   + +Q W   +Q++  S    L+  +   + F      ++ WL E+ 
Sbjct: 3529 EDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3584

Query: 291  LQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
             +L+  +++ +S   +  +  +L+  Q++I L    ++Q +  G +L++++   +  II+
Sbjct: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-----WH 403
            ++L+ ++   +++               L  D     ++ L+L  +  L   H     W 
Sbjct: 3645 DKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHSTHEELCTWL 3689

Query: 404  DRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            D+    LLS +         S +  +P   ++  ++  A +DS+            ++ S
Sbjct: 3690 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-----------NEVSS 3738

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
            A+   +P    EG +               M+ E  E Y +L  + I     +  A   +
Sbjct: 3739 ALLELVPWRAREGLEK--------------MVAEDNERY-RLVSDTITQKVEEIDAAILR 3783

Query: 520  IRQLGKALDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSV 572
             +Q  +A D     I +TE  + S       +  T  +L       M++L      ID +
Sbjct: 3784 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDL 3842

Query: 573  KRLEHKL----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQ 628
             +  HK+     EEE+         S + +   V+  ++ +      + L++++      
Sbjct: 3843 VKSGHKIMTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            QF      +W WL +T+  + QL    L  + +T+  Q ++ ++L++ +   K  I  +N
Sbjct: 3895 QFWETYEELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMN 3952

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
               P+  +    E   +Q++    +  + ++   +++    L +A+ Q   FH+    +L
Sbjct: 3953 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4012

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              LE I  R  +  P   + + E +++   +   +  ++ + Q    +L+    +++  +
Sbjct: 4013 ESLERIVERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4070

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 847
             GTD   + + V    +++  + + +   ++E E KLLDV
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4110



 Score =  104 bits (260), Expect = 4e-22
 Identities = 179/900 (19%), Positives = 361/900 (40%), Gaps = 106/900 (11%)

Query: 39   VKKLKETLVAVQ-QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 94
            +K+ KE + + Q QLD     + SL++W+     ++  PIV  S  +E++ + L + ++L
Sbjct: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKL 2371

Query: 95   QR-------DIEKHSTGVASVLNLCEVLLHDCDACA---------------TDAE----- 127
            Q        +I+K +    S+ NL   +     A A               T+ E     
Sbjct: 2372 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2431

Query: 128  --CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
                SI++   ++   + ++  +  ++  ++       QK  ++ S    WL+   +TA 
Sbjct: 2432 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2491

Query: 186  -FPSSSGVIYTVA-KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQ 242
             +  +     T A K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQ
Sbjct: 2492 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2551

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 302
            M+ E + +W  L +      ++L+       +F+T    +  WL E +L ++ +   S  
Sbjct: 2552 MLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSID 2611

Query: 303  D--VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYC 358
               +  + +Q++   QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +  
Sbjct: 2612 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2671

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
              + G++      + +  +   ++    R L    S  LSDL     S+ ++ +   + N
Sbjct: 2672 DSLTGQLSDRCDWIDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMN 2727

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDK 476
              L  AQ ++ E         V     E     DLS  ++    +A  S   EG  +  K
Sbjct: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFK 2782

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQ 533
            D             + +  E +V+  ++A         A   Q +Q+ +      D++ +
Sbjct: 2783 D-------------VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKE 2821

Query: 534  IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNL 592
             Q   + I +K      L   +K + K L   S   + ++   E+ L + + S    + L
Sbjct: 2822 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2881

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +T      W+    Q   +E ++K++L+K  ++   + ++W W+   +  LE+  
Sbjct: 2882 QLNTIKT-----NWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-- 2934

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             ++   D    E  I KLK LQK +D    ++  +N  +         +   + D    +
Sbjct: 2935 -IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSL 2993

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNL 768
              + D V   L   +  L++   + + F E+S      L    E +D   +      SN 
Sbjct: 2994 IQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3053

Query: 769  DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
               +LQ   K L  +KH++    L     QD+  +   +++GT   +   +V  I     
Sbjct: 3054 YLTMLQTQQKSLQALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHS 3107

Query: 829  LLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 882
             L ++V      LE KL  +   Q  +    S      DELD+   V    GR     QK
Sbjct: 3108 TLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3163



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 166/889 (18%), Positives = 342/889 (38%), Gaps = 95/889 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES----ELA 71
            E++ KL    DR++ L          LK+ +   Q  +     L   L   E+     L+
Sbjct: 1967 EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS 2026

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +PI  D  N   +QR+L E + LQ  I      V  +    EVLL D       A+ D I
Sbjct: 2027 EPIAVDPKN---LQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-DARGSLLPAKND-I 2081

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 191
            Q+   ++  R+ ++     ER  K++ T        D      DW+ + E +        
Sbjct: 2082 QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVP 2141

Query: 192  VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRW 251
            +  T  ++ + K    ++ +    + +  +N++ ++        +A SL+  + + + R+
Sbjct: 2142 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARF 2201

Query: 252  DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-IKQ 310
                 +    L +++    + E FE   + +  +L       T  +  +E DV  K + +
Sbjct: 2202 SEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE------TKTQALTEVDVPGKDVTE 2255

Query: 311  LKAFQQEIS---LNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRR---------- 356
            L  + QE +   L H K +E + +  +++     P D A++ E+ + L +          
Sbjct: 2256 LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK 2315

Query: 357  -------YCQEVFGRVERYHKKL--------IRLPLPDDEHDLSDRELELEDSAALSDLH 401
                    CQE     +   K L         ++P+        D    LED+  L +  
Sbjct: 2316 EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE-K 2374

Query: 402  WHDRSADSLLSP--QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            W      SL +P  Q  +N  +SL   + +  +     A+V S     + +   +   E 
Sbjct: 2375 W------SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2428

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
              ++ L S  ++  D    Y    + L D           K+ E            L ++
Sbjct: 2429 WANKGLTSIKKDMTDISHGYEDLGLLLKD-----------KIAE------------LNTK 2465

Query: 520  IRQLGKALDDSRFQIQQTENIIRSKT-------PTGPE-LDTSYKGYMKLLGECSSSIDS 571
            + +L KA ++S   +Q  + + ++ T       PT  E + T  +       E   +++ 
Sbjct: 2466 LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2525

Query: 572  VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFN 631
            V+ L+ KL E  E  P        +     +  +W+ L    + ++ +++++     QF 
Sbjct: 2526 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2585

Query: 632  SDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCS 691
            +    +  WL   E+EL       LS D   +  Q ++++ L +    RK     +    
Sbjct: 2586 TVEAQLKQWL--VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2643

Query: 692  PEFTQADSKESR---DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                    ++      ++++L+ +  +WD +   L +    +  A+++   +  +   L 
Sbjct: 2644 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2703

Query: 749  LMLENIDRRKNEIVPIDSNLDA--EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV 806
              L ++D + +  + + ++ DA  + L+   K   +I+ E  + ++  A  +D+S   LV
Sbjct: 2704 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA--LV 2761

Query: 807  NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 855
              E     E   ++  I    K + ++   H++ L+     S   Q +S
Sbjct: 2762 KEEYLKA-ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 158/857 (18%), Positives = 337/857 (39%), Gaps = 75/857 (8%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES--ELAKPI 74
            I+  L  ++ +   LLD   AR ++++ T+  +++    +      L   E   E   P+
Sbjct: 3205 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV 3264

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
                  +E I ++LN  +  Q++  +   G    +N     L    A +T  +   ++  
Sbjct: 3265 ---GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHD 3319

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 194
              +++ RW+ +     +R  +++E      +F D       W+  +E   A        +
Sbjct: 3320 LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF 3379

Query: 195  TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 254
             V K ++++ +  QR + +  + +E+I ++  ++A          + + +   + RW+ L
Sbjct: 3380 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3439

Query: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLK 312
              +  +  R+L+      ++F    + +  WLT ++ +L N E        ++ +I Q K
Sbjct: 3440 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3499

Query: 313  AFQQEISLNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV----FGRVER 367
            A + +I +NHNK + Q ++ G+ L   S   D  +++ +LD  + +  E+      R E 
Sbjct: 3500 ALEDDI-INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558

Query: 368  YHKKLIRLPL-PDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
              + L    +  +DE +L +   E+ D   LS L   D S + L   Q    +       
Sbjct: 3559 LQQALCNAKIFGEDEVELMNWLNEVHDK--LSKLSVQDYSTEGLWKQQSELRV------- 3609

Query: 427  LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
                          D +  + + D  L   LE                     L+   G 
Sbjct: 3610 -----------LQEDILLRKQNVDQALLNGLE--------------------LLKQTTGD 3638

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-----QQTENII 541
              ++I +  EA +K     I   S D +    Q  QL + L  +  ++     +    ++
Sbjct: 3639 EVLIIQDKLEA-IKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELL 3697

Query: 542  RSKTPT--GPELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              +T    G E   +     +L  E  ++   +DS+  +   L E    L  +      E
Sbjct: 3698 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE----LVPWRAREGLE 3753

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
               A   +R+ L+      K   +   + + QQF+   ++  +W+ +TE++L  L  + L
Sbjct: 3754 KMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3813

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
              D  + +LQ++K   ++  + H+  I   +       T    +E + ++ +L ++   +
Sbjct: 3814 EQDQTSAQLQVQKTFTME-ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3872

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            D +C +  E    L+ A      F E    L   L       +++ P  + L+ E L+  
Sbjct: 3873 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL-PAPA-LEYETLRQQ 3930

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++  Q++  + E +  +  +     QLL  + G +    +EK          + ++V +
Sbjct: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG-EGFSIQEKYVAADTLYSQIKEDVKK 3989

Query: 837  HIKELEKLLDVSSSQQD 853
                L++ +  S+   D
Sbjct: 3990 RAVALDEAISQSTQFHD 4006



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 152/877 (17%), Positives = 347/877 (39%), Gaps = 83/877 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE++A  +  +   +I  +L  ++ RW+ LL+    R ++L+   V  QQ  + +  L  
Sbjct: 3410 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3469

Query: 62   WLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            WL  IE  L   +PI      + +++ ++ + + L+ DI  H+  +   +++ + L    
Sbjct: 3470 WLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL---- 3522

Query: 120  DACATDAECDSIQQATRNLDRRWR-NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                +  E   + Q+  +  + W   I   S  R   +++     + F +D     +WL 
Sbjct: 3523 -KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3581

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY--------RRLAR 230
                  +  S    +   + E L K ++  R + E +    L+ KQ           L +
Sbjct: 3582 EVHDKLSKLS----VQDYSTEGLWKQQSELRVLQEDI----LLRKQNVDQALLNGLELLK 3633

Query: 231  ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
            +   D    ++  +     R+ ++ K  T + + L+  +       +  + +  WL +++
Sbjct: 3634 QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE 3693

Query: 291  LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
            ++L + E       +A   Q++  + +    +NK          L++    + +A++E  
Sbjct: 3694 VELLSYETQVLKGEEASQAQMRPKELKKEAKNNK---------ALLDSLNEVSSALLELV 3744

Query: 351  LDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADS 409
                R   +++     ERY  +L+         D   +++E  D+A L    + D++AD+
Sbjct: 3745 PWRAREGLEKMVAEDNERY--RLV--------SDTITQKVEEIDAAILRSQQF-DQAADA 3793

Query: 410  LLSPQPSSNLSLSLAQPLRSERSGRDTPASVD-SIPLEWDHDYDLSRDLESAMSRALPSE 468
             LS    +   L     +R E+        V  +  +E     D+  DL  +  + + + 
Sbjct: 3794 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3853

Query: 469  DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD 528
             EE +      L   +   D +   + E Y++L               +S + Q  +  +
Sbjct: 3854 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQL------------ERAQSLVNQFWETYE 3901

Query: 529  DSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +    + +T++II        E +T       ++   +L+ E    ID + +   +L E 
Sbjct: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                 GF    S + +       +  ++     + + + + + +  QF+  ++ I   L 
Sbjct: 3962 SPG-EGF----SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LE 4013

Query: 643  DTEEELEQL-QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
              E  +E+L Q   +S +++ I+ QI + K +   ++  + +  ++     E        
Sbjct: 4014 SLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 4073

Query: 702  SRDL-----QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
             +D+     QD+L QM   W+ + +L+EE    L D +   + F      L++ +++   
Sbjct: 4074 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 4133

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
               ++   D  +D  +++   +    I+ E+   Q  +  + ++  +L+      D    
Sbjct: 4134 FIRDLE--DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4191

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
            K+ +  + +    L K     I +LE+ +  +   QD
Sbjct: 4192 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 73/379 (19%), Positives = 169/379 (44%), Gaps = 17/379 (4%)

Query: 3    ERLAKASHESK---ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            E +A++    K   A  ++ KL ++   W+++  L+  R  KL + +   ++   +  SL
Sbjct: 4065 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4124

Query: 60   RTWLAHIES---ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 116
               +   +    +L  P +  S         + +QQE    I +   G+   L++   L 
Sbjct: 4125 IVTIKDTQDFIRDLEDPGIDPSV--------VKQQQEAAETIREEIDGLQEELDIVINLG 4176

Query: 117  HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 176
             +  A   + +   ++++   L+  W ++     +R  K+EE  +   ++ D      DW
Sbjct: 4177 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4236

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            +  +    A  S  G      K+++++ + F+ + ++   ++E +N Q   L ++   +S
Sbjct: 4237 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEES 4296

Query: 237  -ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
               +++  + E    WD+L++R+ +   +L+  +    +F+ A D +L WLT  +  L+ 
Sbjct: 4297 DKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE 4356

Query: 296  IEHFSECDVQAKIKQLK--AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             +         +I+  K    Q ++  + + +E +   G  LIE S   +A+ ++ +L+ 
Sbjct: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEV 4416

Query: 354  LRRYCQEVFGRVERYHKKL 372
            L +  Q V  + E+  ++L
Sbjct: 4417 LNQRWQNVLEKTEQRKQQL 4435



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 168/922 (18%), Positives = 348/922 (37%), Gaps = 106/922 (11%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L   +  S+ + ++ +L  +   W      +  R  KLKE+L    +  + + +L  
Sbjct: 2864 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 2923

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD- 120
            W+   ++ L +  +    +  E +  + + + LQ+++++H   V  + N    LL  C+ 
Sbjct: 2924 WIDKCQNNLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2981

Query: 121  --ACATDAECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDW 176
                 TD     IQ+     ++   +  C  +M ++ K  +E  +  ++ L       D 
Sbjct: 2982 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3040

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLT 216
            +  S  + A+   S    T+ + + K  +A + QV                     + L 
Sbjct: 3041 IHDSLGSQAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097

Query: 217  QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE 276
            Q+E I +++  L+++   D  CS  +   +G   + N           ++    Q  EF+
Sbjct: 3098 QVETIAQEHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFD 3145

Query: 277  TARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLI 336
               DS    +  +      ++   E  ++A +K+L+A        +   + ++A      
Sbjct: 3146 DELDS----MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----T 3195

Query: 337  EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 396
            E++ P D   I+ +L+ L + C ++  R +   +++       +E     +E     S  
Sbjct: 3196 EETSP-DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SIL 3250

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
            L     H+ S   +     + N  L++ +  + E      P       + W     L + 
Sbjct: 3251 LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQG 3302

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
            L  + +++  ++  E              L DV       A  K     +   +      
Sbjct: 3303 LIQSAAKSTSTQGLEHD------------LDDV------NARWKTLNKKVAQRAAQLQEA 3344

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSID 570
                 +   AL+     +  TE ++ ++ P   E           K   +LL +  S+++
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404

Query: 571  SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 630
             +KR   K+    E       L     Q + +  RWE L  +A ++  +++      QQF
Sbjct: 3405 VIKREGEKIATTAEPADKVKIL----KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3460

Query: 631  NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINL 689
            +  L  +  WL   E+ L   +   + T    +E QI + K L+   ++H K +  ++++
Sbjct: 3461 HETLEPLNEWLTTIEKRLVNCE--PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI 3518

Query: 690  CSPEFTQADSKESRDL-QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                     S+E +D+ Q +L      +  +         LLQ AL   + F E    L+
Sbjct: 3519 -GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              L  +  + +++   D     E L     +L  ++ ++L  +  V        +LL   
Sbjct: 3578 NWLNEVHDKLSKLSVQD--YSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADELD 864
             G + L  ++K+  I  R K + K  +   K LE+ L ++    S+ ++L +W    E++
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695

Query: 865  -TSGSVSPTSGRSTPNRQKTPR 885
              S       G      Q  P+
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPK 3717



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 162/881 (18%), Positives = 342/881 (38%), Gaps = 71/881 (8%)

Query: 6    AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 65
            A+ S     ++I+  L  +  R++ L   +  R +KL+ TL     +   +  +  W+ +
Sbjct: 2070 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2129

Query: 66   IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            +ES L K       NS  +Q  +++   L++DI    + + ++    +  +   D     
Sbjct: 2130 VESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD----P 2184

Query: 126  AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            +   S+Q   ++L  R+        E   K+EE     + F +   + + +L++  +   
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244

Query: 186  FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                 G   T   + +++  +   +  E    LE+++   + ++          + +  +
Sbjct: 2245 EVDVPGKDVTELSQYMQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTN 2301

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDV 304
              ++++  ++  +      +     Q + F+    S+  W+ E   ++  ++  F   D+
Sbjct: 2302 NLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDL 2361

Query: 305  QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE----KSEPLDAAIIEEELDELRRYCQE 360
               ++  K  Q++ SL   +I+++   G  L       + P  A    +    +      
Sbjct: 2362 GKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGT 2421

Query: 361  VFGRVERYHKK---LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
                 E +  K    I+  + D  H   D  L L+D  A      + + +    + + SS
Sbjct: 2422 ATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA----ELNTKLSKLQKAQEESS 2477

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
             +   L +  ++    + TPA  D+  ++   + + S + E      L     + Q+ KD
Sbjct: 2478 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE------LKQNVNKVQELKD 2531

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ---- 533
                      D   PE+P     LTE   K    +   ++ Q +    + + ++FQ    
Sbjct: 2532 KLTELLEENPDT--PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2589

Query: 534  -----IQQTENIIRSKTPTGPE---LDTSYKGYMKLLGECSSSIDSVKRLEH------KL 579
                 + + E ++    P   +   L+T  +    LL E ++     ++L          
Sbjct: 2590 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2649

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
              E+ SL G V     + Q A V  +W+ L  Q   +   + Q + K  Q+ S L S+  
Sbjct: 2650 PGEDPSLRGIV-----KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2704

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV-DHRKAIILSINLCSPEFTQAD 698
             L D + +L     L +ST    +  Q++  +++++ +   +K I ++  LC  E   A 
Sbjct: 2705 KLSDLDNKLS--SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC--EDLSAL 2760

Query: 699  SKE---SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
             KE     +L  +L  +   +  V    E     LQ A      F +MS      L+   
Sbjct: 2761 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820

Query: 756  RRKNEIVPIDSNLDA--EILQDH---HKQLMQIKH----ELLESQ---LRVASLQDMSCQ 803
              +N+  PI + LD    +++DH    K L    H     + E +   L+    +  + Q
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880

Query: 804  LLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 844
            L +N   T+     ++V    N+LK  L++  ++ +++E L
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2921



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 162/891 (18%), Positives = 354/891 (39%), Gaps = 104/891 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            K  ++ +RWQ++   I  R++ L+    +++        L  W+  +E+   K       
Sbjct: 1303 KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 1362

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            NS+ +  +LN+Q+ L  +IE       S ++ C+       A   D E  ++      +D
Sbjct: 1363 NSKTLATQLNQQKMLVSEIEMKQ----SKMDECQKYAEQYSATVKDYELQTMTYRAM-VD 1417

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             + ++     ++RR        + Q+F+D  +R+   +    +   F   S  +  + +E
Sbjct: 1418 SQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEE 1471

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVT 259
            E    E  +  V +     + ++   + L    +       KQ +   ++     +++++
Sbjct: 1472 EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI--SSEEISTKKEQLS 1529

Query: 260  SILRRLKHFIG---------QREEFE----TARDSILVWLTEMDLQLTNIEHFSECDVQA 306
              L+ ++ F+          +R E E    T ++S  +  +E   QL   +   +  V+ 
Sbjct: 1530 EALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEE 1589

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC--QEVFGR 364
            KI   +  QQE       I  ++ Q E  +   +  +A +I +   EL++Y   QE   +
Sbjct: 1590 KIVAER--QQEYKEKLQGICDLLTQTENRLIGHQ--EAFMIGDGTVELKKYQSKQEELQK 1645

Query: 365  VERYHKKLIRLPLPDDEHDLSDRELEL-EDSAALSDLHWHDRSAD----SLLSPQPSSNL 419
              +   + +   + + E+ L +   +L ++  AL +   ++        +L + Q    L
Sbjct: 1646 DMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL 1705

Query: 420  SLSLAQPLRSE-------RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
               +   ++ E       +   ++   ++++ L+W  + D  +D E A ++     ++ G
Sbjct: 1706 DKVVTTAIKEETEKVAAVKQLEESKTKIENL-LDWLSNVD--KDSERAGTKHKQVIEQNG 1762

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRF 532
               ++   + A+G       E  E    L E  +    G      +Q  Q  KA      
Sbjct: 1763 THFQEGDGKSAIG-------EEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA------ 1809

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
               Q E II                   ++   S+ +   K+ ++   EE+E L   +  
Sbjct: 1810 ---QHEKIISQHQAV-------------IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1853

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +TA      ++    +L +EL         ++F++D      WL  +E+ELE L+
Sbjct: 1854 LKVHYETALAESEKKMKLTHSLQEEL---------EKFDADYTEFEHWLQQSEQELENLE 1904

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA-------------DS 699
                + DI  +  ++K+ K   + V   K  +  I +      +A              S
Sbjct: 1905 --AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTS 1962

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
               R++Q +L     R+  + S        L+D + + Q + + S GLL  L+  +   +
Sbjct: 1963 ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS 2022

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 819
            + +     +D + LQ   ++   ++ ++   Q+ V  L+  + ++L++A G+  L AK  
Sbjct: 2023 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK-KTAEVLLDARGS-LLPAKND 2080

Query: 820  VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE-LDTSGSV 869
            +    + +    +++S+ + E  + L ++ + + LS     DE LD  G+V
Sbjct: 2081 IQKTLDDIVGRYEDLSKSVNERNEKLQITLT-RSLSVQDGLDEMLDWMGNV 2130



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 188/971 (19%), Positives = 363/971 (37%), Gaps = 161/971 (16%)

Query: 43   KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 102
            KE +   ++L K +S++   L   E     P      +SEEI  K  +  E         
Sbjct: 1480 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--------- 1530

Query: 103  TGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR--------L 154
                  L   ++ L       TD E + +++  + L   +  + + S+++         +
Sbjct: 1531 -----ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1585

Query: 155  KIEE--TWRLWQKFLDDYSRFEDWLKSSERTA-----AFPSSSGVIYTVAKEELKKFEAF 207
            K+EE       Q++ +      D L  +E        AF    G +      ELKK+++ 
Sbjct: 1586 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV------ELKKYQSK 1639

Query: 208  QRQVH-------ECLTQL------------ELINKQYRRLARENRTDSACSLKQMVHEGN 248
            Q ++        + L ++            E ++++ + L  +   ++    +Q+  +  
Sbjct: 1640 QEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAE 1699

Query: 249  QRWDNLQKRVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLT----------- 294
            Q    L K VT+ ++     +    Q EE +T  +++L WL+ +D               
Sbjct: 1700 QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1759

Query: 295  -NIEHFSECDVQAKIK----------------QLKAFQQEISLNHNKI----EQIIAQ-- 331
             N  HF E D ++ I                 Q+   Q+ ++  + K+    E+II+Q  
Sbjct: 1760 QNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQ 1819

Query: 332  --------GEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD 379
                     + L+EK      P +   +++ + EL+ + +      E+  K         
Sbjct: 1820 AVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT------- 1872

Query: 380  DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 439
              H L + ELE  D+      HW  +S   L + +  ++    L   L+ ++S      S
Sbjct: 1873 --HSLQE-ELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS-----FS 1924

Query: 440  VDSIPLEWDHDYDL---SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
             D I  + D  Y     +R LE+A S    S+ + G+ D     R      D        
Sbjct: 1925 EDVISHKGDLRYITISGNRVLEAAKSC---SKRDGGKVDTSATHREVQRKLDHATDRFRS 1981

Query: 497  AYVK--LTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
             Y K  +  N +K+    +   E     L   L     +   ++++          L   
Sbjct: 1982 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC--EATASKHLSEPIAVDPKNLQRQ 2039

Query: 555  YKGYMKLLGECSSSIDSVKRL----EHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 610
             +    L G+ SS   +V++L    E  L      LP   ++  T     G   R+E L 
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG---RYEDLS 2096

Query: 611  AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL-STDIQTIELQIKK 669
                 +  +++  L +       L+ +  W+G+ E  L++  ++ L ST +Q I   I K
Sbjct: 2097 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISK 2153

Query: 670  LKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 728
               L++ +  R++ I ++N    +F +  D   +  LQ ++  ++ R+       +E   
Sbjct: 2154 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2213

Query: 729  LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI-VP-IDSNLDAEILQDHHKQLMQIKH- 785
             +++   + + F  +S  L   LE   +   E+ VP  D    ++ +Q+   + ++ K  
Sbjct: 2214 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 2273

Query: 786  -ELLESQLRVASLQDMSCQLLVNAEGTDCL------------EAKEKVHVIGNRL---KL 829
             E+L S L+  S   +     +  E T+ L            E KE V     +L   ++
Sbjct: 2274 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 2333

Query: 830  LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCS 889
            L+K +   IKE  K + +   Q    +      L+ +  +       TP  QK      S
Sbjct: 2334 LVKSLKSWIKETTKKVPI--VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2391

Query: 890  LSQPGPSVSSP 900
            L     +V++P
Sbjct: 2392 LCNLISAVTTP 2402



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 149/753 (19%), Positives = 298/753 (39%), Gaps = 117/753 (15%)

Query: 171  SRFEDWLKSSERTAAFPSSS--------GVIYTVAKEELKKFEAFQRQVHECLTQLELIN 222
            SRFED+L+ S+ +  F  S          V     +E LK  E  + +  E +  L +  
Sbjct: 1054 SRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE--REEQEESVYNLYISE 1111

Query: 223  KQYRRLARENRTDSACSLKQMVHEGNQRWDNL-----QKRVTSILRRLKHFIG----QRE 273
             +  RL  EN  D      +   E +   +++     Q+++   L RLK  +G    + E
Sbjct: 1112 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1171

Query: 274  EF---ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 330
            EF     A  S+    +E+++ L N+           I +LK     +  N    E ++ 
Sbjct: 1172 EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMS-STYIDKLKTVNLVLK-NTQAAEALVK 1229

Query: 331  QGEQLIEKSEPL--DAAIIEEELDELRRYCQEVFGRVERYH---KKLIRLPLPDDEHDLS 385
              E  + + E +  D   IE  +  L+++  EV  + + +H    +L +     DE   +
Sbjct: 1230 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1289

Query: 386  DRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS-ERSGRDTPASVDSI- 443
             +E +L       D  WH   AD L+  +   N+ + +   LR  E  G+      D+  
Sbjct: 1290 YKERDL-------DFDWHKEKADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1340

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            PL+     D  + +E+   +   ++ E  +       +  + +S++ + +S     +   
Sbjct: 1341 PLD-----DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1395

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDS---RFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
                 T  D+       R +  +   S   R ++Q + ++I  +     +L T Y   + 
Sbjct: 1396 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF---MDLRTRYTALVT 1452

Query: 561  LLGE-CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRW------ELLQAQA 613
            L+ +    + DS+KRLE    EEE+SL      H    + A  + +W       L  A+ 
Sbjct: 1453 LMTQYIKFAGDSLKRLE----EEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEK 1505

Query: 614  LSKELRMKQNLQ------KWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE--- 664
              K    KQ +       K +Q +  L +I  +L    +++   +R EL   ++T++   
Sbjct: 1506 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESY 1565

Query: 665  --LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCS 721
              L  + LK+LQ++                  T  D K E + + +R  +   +   +C 
Sbjct: 1566 NLLFSESLKQLQESQ-----------------TSGDVKVEEKIVAERQQEYKEKLQGICD 1608

Query: 722  LLEEWRG---------LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            LL +            ++ D  ++ + +      L   ++   +   E+V    N     
Sbjct: 1609 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN----F 1664

Query: 773  LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            L+++ ++L Q    L+E +L  A ++   C+ L        L+A++    +   +   +K
Sbjct: 1665 LKENGEKLSQEDKALIEQKLNEAKIK---CEQL-------NLKAEQSKKELDKVVTTAIK 1714

Query: 833  EVSRHIKELEKLLDVSSSQQDLSSWSSADELDT 865
            E +  +  +++L +  +  ++L  W S  + D+
Sbjct: 1715 EETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1747



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 119/677 (17%), Positives = 261/677 (38%), Gaps = 100/677 (14%)

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            D + D  ++    L  RW+N+      R   +E   +  + + D Y   +DW++  E T 
Sbjct: 1294 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353

Query: 185  A-----FPSSSGVIYTVAKEE---LKKFEAFQRQVHEC----------LTQLELINKQYR 226
                   P +S  + T   ++   + + E  Q ++ EC          +   EL    YR
Sbjct: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1413

Query: 227  RLARENRTDSACSLKQMVHEGN---QRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 283
             +  +++  S    ++M    +   Q + +L+ R T+++  +  +I      + A DS+ 
Sbjct: 1414 AMV-DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI------KFAGDSL- 1465

Query: 284  VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 343
                    +L   E   E + +  +++ K  Q+ +S     ++     G+    K +   
Sbjct: 1466 -------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK--- 1515

Query: 344  AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 403
              I  EE+   +    E    ++ +  K       ++ ++L  +   L++S  L      
Sbjct: 1516 --ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL----LF 1569

Query: 404  DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD-----HDYDLSRDLE 458
              S   L   Q S ++ +        ++  ++    +  +  + +     H         
Sbjct: 1570 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1629

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
            +   +   S+ EE Q D       A  L++V+  ++ E ++K  EN  K +  D + +E 
Sbjct: 1630 TVELKKYQSKQEELQKDMQ---GSAQALAEVV--KNTENFLK--ENGEKLSQEDKALIEQ 1682

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++ +     +    + +Q++           ELD   K     + E +  + +VK+LE  
Sbjct: 1683 KLNEAKIKCEQLNLKAEQSKK----------ELD---KVVTTAIKEETEKVAAVKQLEES 1729

Query: 579  LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL--NS 636
             K + E+L  +++    +++ AG   +  + Q     +E   K  + +  + N +L    
Sbjct: 1730 -KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788

Query: 637  IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKAIILSIN----LCS 691
            +   +G T+E L Q               Q +K+K + +K +   +A+I++      L  
Sbjct: 1789 VDGQVGTTQENLNQ---------------QYQKVKAQHEKIISQHQAVIIATQSAQVLLE 1833

Query: 692  PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL---LQDALMQCQG-FHEMSHGL 747
             +      +E   LQ  + ++   ++   +  E+   L   LQ+ L +    + E  H L
Sbjct: 1834 KQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWL 1893

Query: 748  LLM---LENIDRRKNEI 761
                  LEN++   ++I
Sbjct: 1894 QQSEQELENLEAGADDI 1910



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 61/327 (18%), Positives = 134/327 (40%), Gaps = 36/327 (11%)

Query: 499 VKLTENAIKNTSGDHSALESQI-----RQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 553
           +++ +  +K++  D +  E +I     + L   +D+ + Q+ +TE    S  P+      
Sbjct: 622 MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE--WGSDLPSVESHLE 679

Query: 554 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 613
           ++K   + + E  SS+      E K+ E + + P        +   A  + R E   A+ 
Sbjct: 680 NHKNVHRAIEEFESSLK-----EAKISEIQMTAP-------LKLTYAEKLHRLESQYAKL 727

Query: 614 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-- 671
           L+     +++L     F S   +   WL + EEE       E++ D       I + K  
Sbjct: 728 LNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE-------EVAYDWSERNTNIARKKDY 780

Query: 672 --ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 729
             EL + +D ++  I S+   + +    +      ++   + M  +W  +  L +     
Sbjct: 781 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 840

Query: 730 LQDALMQCQGFHEMSHG--LLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 787
           +++     + F++       L  L++  +RK      D +     L+D  ++ M+ K EL
Sbjct: 841 IKENTAYFEFFNDAKEATDYLRNLKDAIQRK---YSCDRSSSIHKLEDLVQESMEEKEEL 897

Query: 788 LESQLRVASLQDMSCQLL-VNAEGTDC 813
           L+ +  +A+L   +  ++ +    +DC
Sbjct: 898 LQYKSTIANLMGKAKTIIQLKPRNSDC 924


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  126 bits (316), Expect = 1e-28
 Identities = 163/868 (18%), Positives = 352/868 (40%), Gaps = 63/868 (7%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q    + ++ 
Sbjct: 4313 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVF 4372

Query: 61   TWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
             W+     +LA   PI  D    E +++++ E ++ + +  +    +  + +  E+LL  
Sbjct: 4373 DWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK 4429

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                  +++  ++Q     L   W ++    + R+ K+E       +F         WL 
Sbjct: 4430 V---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLT 4486

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   +     G      + EL K    Q  V    + +E +NK    L   +  + A 
Sbjct: 4487 HTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEAS 4546

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
            +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ +  L   + 
Sbjct: 4547 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4606

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEELDELR 355
                   AK +QL    +  +    K E    ++ +G+Q++ +        I+++++ L+
Sbjct: 4607 LGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4665

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL-LSPQ 414
               + V                   E  L++R+ +LE++  L+ + +H+   D +    Q
Sbjct: 4666 EKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFINWLTQ 4705

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
                L+++    L            +D++  + D     + ++ S   + +   D+ G  
Sbjct: 4706 AEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQII-ELDKTGTH 4753

Query: 475  DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
             K F  +  V L   ++      + K+ +  ++       A   + +Q  +A       +
Sbjct: 4754 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAWSKLMEWL 4812

Query: 535  QQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 588
            +++E  + S+     + D        +K + K LG   S  D+  R    LKE+      
Sbjct: 4813 EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADD 4872

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 648
             + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL   E +L
Sbjct: 4873 NLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4929

Query: 649  EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
             + Q   +  DI  +   I   K  QK +  R + + ++   + E  +    +S  ++ +
Sbjct: 4930 AEDQ--PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4987

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDS 766
            + +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R + ++P D 
Sbjct: 4988 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 5047

Query: 767  NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 826
            +     L D HK+ M+   +L E +  +     M   +L           K  + +I  R
Sbjct: 5048 DA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 5103

Query: 827  LKLLLKEVSRHIKELEKLLDVSSSQQDL 854
             + +L    +H + L   L    ++Q+L
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQEL 5131



 Score =  120 bits (301), Expect = 6e-27
 Identities = 169/880 (19%), Positives = 375/880 (42%), Gaps = 101/880 (11%)

Query: 1    MGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            +G+ L +++ +S +++ +E+ L  VN RW+ L   +A R  +L+E L+   +    + SL
Sbjct: 3437 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3496

Query: 60   RTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
             +W+   E  +A  KP    S   + ++ ++ EQ+ LQR ++   + V       EV+  
Sbjct: 3497 LSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKR 3546

Query: 118  DCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
            + +  AT AE  D ++  +    LD RW  +   +  R  ++E    + Q+F +      
Sbjct: 3547 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3606

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINKQYRRLARE 231
            +WL + E+        G   +  +E++ + +A +  +   ++ L Q   I +  + L+  
Sbjct: 3607 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR 3666

Query: 232  NRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
               D    + Q   + +Q W   +Q++  S    L+  +   + F      ++ WL E+ 
Sbjct: 3667 EDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3722

Query: 291  LQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
             +L+  +++ +S   +  +  +L+  Q++I L    ++Q +  G +L++++   +  II+
Sbjct: 3723 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3782

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-----WH 403
            ++L+ ++   +++               L  D     ++ L+L  +  L   H     W 
Sbjct: 3783 DKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHSTHEELCTWL 3827

Query: 404  DRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            D+    LLS +         S +  +P   ++  ++  A +DS+            ++ S
Sbjct: 3828 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-----------NEVSS 3876

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
            A+   +P    EG +               M+ E  E Y +L  + I     +  A   +
Sbjct: 3877 ALLELVPWRAREGLEK--------------MVAEDNERY-RLVSDTITQKVEEIDAAILR 3921

Query: 520  IRQLGKALDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSV 572
             +Q  +A D     I +TE  + S       +  T  +L       M++L      ID +
Sbjct: 3922 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDL 3980

Query: 573  KRLEHKL----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQ 628
             +  HK+     EEE+         S + +   V+  ++ +      + L++++      
Sbjct: 3981 VKSGHKIMTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 4032

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            QF      +W WL +T+  + QL    L  + +T+  Q ++ ++L++ +   K  I  +N
Sbjct: 4033 QFWETYEELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMN 4090

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
               P+  +    E   +Q++    +  + ++   +++    L +A+ Q   FH+    +L
Sbjct: 4091 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4150

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              LE I  R  +  P   + + E +++   +   +  ++ + Q    +L+    +++  +
Sbjct: 4151 ESLERIVERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4208

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 847
             GTD   + + V    +++  + + +   ++E E KLLDV
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4248



 Score =  104 bits (260), Expect = 4e-22
 Identities = 179/900 (19%), Positives = 361/900 (40%), Gaps = 106/900 (11%)

Query: 39   VKKLKETLVAVQ-QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 94
            +K+ KE + + Q QLD     + SL++W+     ++  PIV  S  +E++ + L + ++L
Sbjct: 2452 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKL 2509

Query: 95   QR-------DIEKHSTGVASVLNLCEVLLHDCDACA---------------TDAE----- 127
            Q        +I+K +    S+ NL   +     A A               T+ E     
Sbjct: 2510 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2569

Query: 128  --CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
                SI++   ++   + ++  +  ++  ++       QK  ++ S    WL+   +TA 
Sbjct: 2570 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2629

Query: 186  -FPSSSGVIYTVA-KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQ 242
             +  +     T A K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQ
Sbjct: 2630 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2689

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 302
            M+ E + +W  L +      ++L+       +F+T    +  WL E +L ++ +   S  
Sbjct: 2690 MLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSID 2749

Query: 303  D--VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYC 358
               +  + +Q++   QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +  
Sbjct: 2750 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2809

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
              + G++      + +  +   ++    R L    S  LSDL     S+ ++ +   + N
Sbjct: 2810 DSLTGQLSDRCDWIDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMN 2865

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDK 476
              L  AQ ++ E         V     E     DLS  ++    +A  S   EG  +  K
Sbjct: 2866 QQLETAQKMKQEIQQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFK 2920

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQ 533
            D             + +  E +V+  ++A         A   Q +Q+ +      D++ +
Sbjct: 2921 D-------------VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKE 2959

Query: 534  IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNL 592
             Q   + I +K      L   +K + K L   S   + ++   E+ L + + S    + L
Sbjct: 2960 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 3019

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +T      W+    Q   +E ++K++L+K  ++   + ++W W+   +  LE+  
Sbjct: 3020 QLNTIKT-----NWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-- 3072

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             ++   D    E  I KLK LQK +D    ++  +N  +         +   + D    +
Sbjct: 3073 -IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSL 3131

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNL 768
              + D V   L   +  L++   + + F E+S      L    E +D   +      SN 
Sbjct: 3132 IQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3191

Query: 769  DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
               +LQ   K L  +KH++    L     QD+  +   +++GT   +   +V  I     
Sbjct: 3192 YLTMLQTQQKSLQALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHS 3245

Query: 829  LLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 882
             L ++V      LE KL  +   Q  +    S      DELD+   V    GR     QK
Sbjct: 3246 TLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3301



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 166/889 (18%), Positives = 342/889 (38%), Gaps = 95/889 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES----ELA 71
            E++ KL    DR++ L          LK+ +   Q  +     L   L   E+     L+
Sbjct: 2105 EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS 2164

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +PI  D  N   +QR+L E + LQ  I      V  +    EVLL D       A+ D I
Sbjct: 2165 EPIAVDPKN---LQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-DARGSLLPAKND-I 2219

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 191
            Q+   ++  R+ ++     ER  K++ T        D      DW+ + E +        
Sbjct: 2220 QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVP 2279

Query: 192  VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRW 251
            +  T  ++ + K    ++ +    + +  +N++ ++        +A SL+  + + + R+
Sbjct: 2280 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARF 2339

Query: 252  DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-IKQ 310
                 +    L +++    + E FE   + +  +L       T  +  +E DV  K + +
Sbjct: 2340 SEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE------TKTQALTEVDVPGKDVTE 2393

Query: 311  LKAFQQEIS---LNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRR---------- 356
            L  + QE +   L H K +E + +  +++     P D A++ E+ + L +          
Sbjct: 2394 LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK 2453

Query: 357  -------YCQEVFGRVERYHKKL--------IRLPLPDDEHDLSDRELELEDSAALSDLH 401
                    CQE     +   K L         ++P+        D    LED+  L +  
Sbjct: 2454 EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE-K 2512

Query: 402  WHDRSADSLLSP--QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            W      SL +P  Q  +N  +SL   + +  +     A+V S     + +   +   E 
Sbjct: 2513 W------SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2566

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
              ++ L S  ++  D    Y    + L D           K+ E            L ++
Sbjct: 2567 WANKGLTSIKKDMTDISHGYEDLGLLLKD-----------KIAE------------LNTK 2603

Query: 520  IRQLGKALDDSRFQIQQTENIIRSKT-------PTGPE-LDTSYKGYMKLLGECSSSIDS 571
            + +L KA ++S   +Q  + + ++ T       PT  E + T  +       E   +++ 
Sbjct: 2604 LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2663

Query: 572  VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFN 631
            V+ L+ KL E  E  P        +     +  +W+ L    + ++ +++++     QF 
Sbjct: 2664 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2723

Query: 632  SDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCS 691
            +    +  WL   E+EL       LS D   +  Q ++++ L +    RK     +    
Sbjct: 2724 TVEAQLKQWL--VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2781

Query: 692  PEFTQADSKESR---DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                    ++      ++++L+ +  +WD +   L +    +  A+++   +  +   L 
Sbjct: 2782 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2841

Query: 749  LMLENIDRRKNEIVPIDSNLDA--EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV 806
              L ++D + +  + + ++ DA  + L+   K   +I+ E  + ++  A  +D+S   LV
Sbjct: 2842 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA--LV 2899

Query: 807  NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 855
              E     E   ++  I    K + ++   H++ L+     S   Q +S
Sbjct: 2900 KEEYLKA-ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2947



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 158/857 (18%), Positives = 337/857 (39%), Gaps = 75/857 (8%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES--ELAKPI 74
            I+  L  ++ +   LLD   AR ++++ T+  +++    +      L   E   E   P+
Sbjct: 3343 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV 3402

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
                  +E I ++LN  +  Q++  +   G    +N     L    A +T  +   ++  
Sbjct: 3403 ---GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHD 3457

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 194
              +++ RW+ +     +R  +++E      +F D       W+  +E   A        +
Sbjct: 3458 LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF 3517

Query: 195  TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 254
             V K ++++ +  QR + +  + +E+I ++  ++A          + + +   + RW+ L
Sbjct: 3518 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3577

Query: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLK 312
              +  +  R+L+      ++F    + +  WLT ++ +L N E        ++ +I Q K
Sbjct: 3578 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3637

Query: 313  AFQQEISLNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV----FGRVER 367
            A + +I +NHNK + Q ++ G+ L   S   D  +++ +LD  + +  E+      R E 
Sbjct: 3638 ALEDDI-INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3696

Query: 368  YHKKLIRLPL-PDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
              + L    +  +DE +L +   E+ D   LS L   D S + L   Q    +       
Sbjct: 3697 LQQALCNAKIFGEDEVELMNWLNEVHDK--LSKLSVQDYSTEGLWKQQSELRV------- 3747

Query: 427  LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
                          D +  + + D  L   LE                     L+   G 
Sbjct: 3748 -----------LQEDILLRKQNVDQALLNGLE--------------------LLKQTTGD 3776

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-----QQTENII 541
              ++I +  EA +K     I   S D +    Q  QL + L  +  ++     +    ++
Sbjct: 3777 EVLIIQDKLEA-IKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELL 3835

Query: 542  RSKTPT--GPELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              +T    G E   +     +L  E  ++   +DS+  +   L E    L  +      E
Sbjct: 3836 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE----LVPWRAREGLE 3891

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
               A   +R+ L+      K   +   + + QQF+   ++  +W+ +TE++L  L  + L
Sbjct: 3892 KMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3951

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
              D  + +LQ++K   ++  + H+  I   +       T    +E + ++ +L ++   +
Sbjct: 3952 EQDQTSAQLQVQKTFTME-ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 4010

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            D +C +  E    L+ A      F E    L   L       +++ P  + L+ E L+  
Sbjct: 4011 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL-PAPA-LEYETLRQQ 4068

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++  Q++  + E +  +  +     QLL  + G +    +EK          + ++V +
Sbjct: 4069 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG-EGFSIQEKYVAADTLYSQIKEDVKK 4127

Query: 837  HIKELEKLLDVSSSQQD 853
                L++ +  S+   D
Sbjct: 4128 RAVALDEAISQSTQFHD 4144



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 152/877 (17%), Positives = 347/877 (39%), Gaps = 83/877 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE++A  +  +   +I  +L  ++ RW+ LL+    R ++L+   V  QQ  + +  L  
Sbjct: 3548 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3607

Query: 62   WLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            WL  IE  L   +PI      + +++ ++ + + L+ DI  H+  +   +++ + L    
Sbjct: 3608 WLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL---- 3660

Query: 120  DACATDAECDSIQQATRNLDRRWR-NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                +  E   + Q+  +  + W   I   S  R   +++     + F +D     +WL 
Sbjct: 3661 -KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3719

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY--------RRLAR 230
                  +  S    +   + E L K ++  R + E +    L+ KQ           L +
Sbjct: 3720 EVHDKLSKLS----VQDYSTEGLWKQQSELRVLQEDI----LLRKQNVDQALLNGLELLK 3771

Query: 231  ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
            +   D    ++  +     R+ ++ K  T + + L+  +       +  + +  WL +++
Sbjct: 3772 QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE 3831

Query: 291  LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
            ++L + E       +A   Q++  + +    +NK          L++    + +A++E  
Sbjct: 3832 VELLSYETQVLKGEEASQAQMRPKELKKEAKNNK---------ALLDSLNEVSSALLELV 3882

Query: 351  LDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADS 409
                R   +++     ERY  +L+         D   +++E  D+A L    + D++AD+
Sbjct: 3883 PWRAREGLEKMVAEDNERY--RLV--------SDTITQKVEEIDAAILRSQQF-DQAADA 3931

Query: 410  LLSPQPSSNLSLSLAQPLRSERSGRDTPASVD-SIPLEWDHDYDLSRDLESAMSRALPSE 468
             LS    +   L     +R E+        V  +  +E     D+  DL  +  + + + 
Sbjct: 3932 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3991

Query: 469  DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD 528
             EE +      L   +   D +   + E Y++L               +S + Q  +  +
Sbjct: 3992 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQL------------ERAQSLVNQFWETYE 4039

Query: 529  DSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +    + +T++II        E +T       ++   +L+ E    ID + +   +L E 
Sbjct: 4040 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 4099

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                 GF    S + +       +  ++     + + + + + +  QF+  ++ I   L 
Sbjct: 4100 SPG-EGF----SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LE 4151

Query: 643  DTEEELEQL-QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
              E  +E+L Q   +S +++ I+ QI + K +   ++  + +  ++     E        
Sbjct: 4152 SLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 4211

Query: 702  SRDL-----QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
             +D+     QD+L QM   W+ + +L+EE    L D +   + F      L++ +++   
Sbjct: 4212 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 4271

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
               ++   D  +D  +++   +    I+ E+   Q  +  + ++  +L+      D    
Sbjct: 4272 FIRDLE--DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4329

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
            K+ +  + +    L K     I +LE+ +  +   QD
Sbjct: 4330 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4366



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 73/379 (19%), Positives = 169/379 (44%), Gaps = 17/379 (4%)

Query: 3    ERLAKASHESK---ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            E +A++    K   A  ++ KL ++   W+++  L+  R  KL + +   ++   +  SL
Sbjct: 4203 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4262

Query: 60   RTWLAHIES---ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 116
               +   +    +L  P +  S         + +QQE    I +   G+   L++   L 
Sbjct: 4263 IVTIKDTQDFIRDLEDPGIDPSV--------VKQQQEAAETIREEIDGLQEELDIVINLG 4314

Query: 117  HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 176
             +  A   + +   ++++   L+  W ++     +R  K+EE  +   ++ D      DW
Sbjct: 4315 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4374

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            +  +    A  S  G      K+++++ + F+ + ++   ++E +N Q   L ++   +S
Sbjct: 4375 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEES 4434

Query: 237  -ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
               +++  + E    WD+L++R+ +   +L+  +    +F+ A D +L WLT  +  L+ 
Sbjct: 4435 DKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE 4494

Query: 296  IEHFSECDVQAKIKQLK--AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             +         +I+  K    Q ++  + + +E +   G  LIE S   +A+ ++ +L+ 
Sbjct: 4495 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEV 4554

Query: 354  LRRYCQEVFGRVERYHKKL 372
            L +  Q V  + E+  ++L
Sbjct: 4555 LNQRWQNVLEKTEQRKQQL 4573



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 168/922 (18%), Positives = 348/922 (37%), Gaps = 106/922 (11%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L   +  S+ + ++ +L  +   W      +  R  KLKE+L    +  + + +L  
Sbjct: 3002 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 3061

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD- 120
            W+   ++ L +  +    +  E +  + + + LQ+++++H   V  + N    LL  C+ 
Sbjct: 3062 WIDKCQNNLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 3119

Query: 121  --ACATDAECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDW 176
                 TD     IQ+     ++   +  C  +M ++ K  +E  +  ++ L       D 
Sbjct: 3120 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3178

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLT 216
            +  S  + A+   S    T+ + + K  +A + QV                     + L 
Sbjct: 3179 IHDSLGSQAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3235

Query: 217  QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE 276
            Q+E I +++  L+++   D  CS  +   +G   + N           ++    Q  EF+
Sbjct: 3236 QVETIAQEHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFD 3283

Query: 277  TARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLI 336
               DS    +  +      ++   E  ++A +K+L+A        +   + ++A      
Sbjct: 3284 DELDS----MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----T 3333

Query: 337  EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 396
            E++ P D   I+ +L+ L + C ++  R +   +++       +E     +E     S  
Sbjct: 3334 EETSP-DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SIL 3388

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
            L     H+ S   +     + N  L++ +  + E      P       + W     L + 
Sbjct: 3389 LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQG 3440

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
            L  + +++  ++  E              L DV       A  K     +   +      
Sbjct: 3441 LIQSAAKSTSTQGLEHD------------LDDV------NARWKTLNKKVAQRAAQLQEA 3482

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSID 570
                 +   AL+     +  TE ++ ++ P   E           K   +LL +  S+++
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3542

Query: 571  SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 630
             +KR   K+    E       L     Q + +  RWE L  +A ++  +++      QQF
Sbjct: 3543 VIKREGEKIATTAEPADKVKIL----KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3598

Query: 631  NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINL 689
            +  L  +  WL   E+ L   +   + T    +E QI + K L+   ++H K +  ++++
Sbjct: 3599 HETLEPLNEWLTTIEKRLVNCE--PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI 3656

Query: 690  CSPEFTQADSKESRDL-QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                     S+E +D+ Q +L      +  +         LLQ AL   + F E    L+
Sbjct: 3657 -GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3715

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              L  +  + +++   D     E L     +L  ++ ++L  +  V        +LL   
Sbjct: 3716 NWLNEVHDKLSKLSVQD--YSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3773

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADELD 864
             G + L  ++K+  I  R K + K  +   K LE+ L ++    S+ ++L +W    E++
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833

Query: 865  -TSGSVSPTSGRSTPNRQKTPR 885
              S       G      Q  P+
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPK 3855



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 162/881 (18%), Positives = 342/881 (38%), Gaps = 71/881 (8%)

Query: 6    AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 65
            A+ S     ++I+  L  +  R++ L   +  R +KL+ TL     +   +  +  W+ +
Sbjct: 2208 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2267

Query: 66   IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            +ES L K       NS  +Q  +++   L++DI    + + ++    +  +   D     
Sbjct: 2268 VESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD----P 2322

Query: 126  AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            +   S+Q   ++L  R+        E   K+EE     + F +   + + +L++  +   
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2382

Query: 186  FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                 G   T   + +++  +   +  E    LE+++   + ++          + +  +
Sbjct: 2383 EVDVPGKDVTELSQYMQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTN 2439

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDV 304
              ++++  ++  +      +     Q + F+    S+  W+ E   ++  ++  F   D+
Sbjct: 2440 NLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDL 2499

Query: 305  QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE----KSEPLDAAIIEEELDELRRYCQE 360
               ++  K  Q++ SL   +I+++   G  L       + P  A    +    +      
Sbjct: 2500 GKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGT 2559

Query: 361  VFGRVERYHKK---LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
                 E +  K    I+  + D  H   D  L L+D  A      + + +    + + SS
Sbjct: 2560 ATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA----ELNTKLSKLQKAQEESS 2615

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
             +   L +  ++    + TPA  D+  ++   + + S + E      L     + Q+ KD
Sbjct: 2616 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE------LKQNVNKVQELKD 2669

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ---- 533
                      D   PE+P     LTE   K    +   ++ Q +    + + ++FQ    
Sbjct: 2670 KLTELLEENPDT--PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2727

Query: 534  -----IQQTENIIRSKTPTGPE---LDTSYKGYMKLLGECSSSIDSVKRLEH------KL 579
                 + + E ++    P   +   L+T  +    LL E ++     ++L          
Sbjct: 2728 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2787

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
              E+ SL G V     + Q A V  +W+ L  Q   +   + Q + K  Q+ S L S+  
Sbjct: 2788 PGEDPSLRGIV-----KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2842

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV-DHRKAIILSINLCSPEFTQAD 698
             L D + +L     L +ST    +  Q++  +++++ +   +K I ++  LC  E   A 
Sbjct: 2843 KLSDLDNKLS--SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC--EDLSAL 2898

Query: 699  SKE---SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
             KE     +L  +L  +   +  V    E     LQ A      F +MS      L+   
Sbjct: 2899 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2958

Query: 756  RRKNEIVPIDSNLDA--EILQDH---HKQLMQIKH----ELLESQ---LRVASLQDMSCQ 803
              +N+  PI + LD    +++DH    K L    H     + E +   L+    +  + Q
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 3018

Query: 804  LLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 844
            L +N   T+     ++V    N+LK  L++  ++ +++E L
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 3059



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 162/891 (18%), Positives = 354/891 (39%), Gaps = 104/891 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            K  ++ +RWQ++   I  R++ L+    +++        L  W+  +E+   K       
Sbjct: 1441 KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 1500

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            NS+ +  +LN+Q+ L  +IE       S ++ C+       A   D E  ++      +D
Sbjct: 1501 NSKTLATQLNQQKMLVSEIEMKQ----SKMDECQKYAEQYSATVKDYELQTMTYRAM-VD 1555

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             + ++     ++RR        + Q+F+D  +R+   +    +   F   S  +  + +E
Sbjct: 1556 SQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEE 1609

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVT 259
            E    E  +  V +     + ++   + L    +       KQ +   ++     +++++
Sbjct: 1610 EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI--SSEEISTKKEQLS 1667

Query: 260  SILRRLKHFIG---------QREEFE----TARDSILVWLTEMDLQLTNIEHFSECDVQA 306
              L+ ++ F+          +R E E    T ++S  +  +E   QL   +   +  V+ 
Sbjct: 1668 EALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEE 1727

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC--QEVFGR 364
            KI   +  QQE       I  ++ Q E  +   +  +A +I +   EL++Y   QE   +
Sbjct: 1728 KIVAER--QQEYKEKLQGICDLLTQTENRLIGHQ--EAFMIGDGTVELKKYQSKQEELQK 1783

Query: 365  VERYHKKLIRLPLPDDEHDLSDRELEL-EDSAALSDLHWHDRSAD----SLLSPQPSSNL 419
              +   + +   + + E+ L +   +L ++  AL +   ++        +L + Q    L
Sbjct: 1784 DMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL 1843

Query: 420  SLSLAQPLRSE-------RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
               +   ++ E       +   ++   ++++ L+W  + D  +D E A ++     ++ G
Sbjct: 1844 DKVVTTAIKEETEKVAAVKQLEESKTKIENL-LDWLSNVD--KDSERAGTKHKQVIEQNG 1900

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRF 532
               ++   + A+G       E  E    L E  +    G      +Q  Q  KA      
Sbjct: 1901 THFQEGDGKSAIG-------EEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA------ 1947

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
               Q E II                   ++   S+ +   K+ ++   EE+E L   +  
Sbjct: 1948 ---QHEKIISQHQAV-------------IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1991

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +TA      ++    +L +EL         ++F++D      WL  +E+ELE L+
Sbjct: 1992 LKVHYETALAESEKKMKLTHSLQEEL---------EKFDADYTEFEHWLQQSEQELENLE 2042

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA-------------DS 699
                + DI  +  ++K+ K   + V   K  +  I +      +A              S
Sbjct: 2043 --AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTS 2100

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
               R++Q +L     R+  + S        L+D + + Q + + S GLL  L+  +   +
Sbjct: 2101 ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS 2160

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 819
            + +     +D + LQ   ++   ++ ++   Q+ V  L+  + ++L++A G+  L AK  
Sbjct: 2161 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK-KTAEVLLDARGS-LLPAKND 2218

Query: 820  VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE-LDTSGSV 869
            +    + +    +++S+ + E  + L ++ + + LS     DE LD  G+V
Sbjct: 2219 IQKTLDDIVGRYEDLSKSVNERNEKLQITLT-RSLSVQDGLDEMLDWMGNV 2268



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 188/971 (19%), Positives = 363/971 (37%), Gaps = 161/971 (16%)

Query: 43   KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 102
            KE +   ++L K +S++   L   E     P      +SEEI  K  +  E         
Sbjct: 1618 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--------- 1668

Query: 103  TGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR--------L 154
                  L   ++ L       TD E + +++  + L   +  + + S+++         +
Sbjct: 1669 -----ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1723

Query: 155  KIEE--TWRLWQKFLDDYSRFEDWLKSSERTA-----AFPSSSGVIYTVAKEELKKFEAF 207
            K+EE       Q++ +      D L  +E        AF    G +      ELKK+++ 
Sbjct: 1724 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV------ELKKYQSK 1777

Query: 208  QRQVH-------ECLTQL------------ELINKQYRRLARENRTDSACSLKQMVHEGN 248
            Q ++        + L ++            E ++++ + L  +   ++    +Q+  +  
Sbjct: 1778 QEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAE 1837

Query: 249  QRWDNLQKRVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLT----------- 294
            Q    L K VT+ ++     +    Q EE +T  +++L WL+ +D               
Sbjct: 1838 QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1897

Query: 295  -NIEHFSECDVQAKIK----------------QLKAFQQEISLNHNKI----EQIIAQ-- 331
             N  HF E D ++ I                 Q+   Q+ ++  + K+    E+II+Q  
Sbjct: 1898 QNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQ 1957

Query: 332  --------GEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD 379
                     + L+EK      P +   +++ + EL+ + +      E+  K         
Sbjct: 1958 AVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT------- 2010

Query: 380  DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 439
              H L + ELE  D+      HW  +S   L + +  ++    L   L+ ++S      S
Sbjct: 2011 --HSLQE-ELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS-----FS 2062

Query: 440  VDSIPLEWDHDYDL---SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
             D I  + D  Y     +R LE+A S    S+ + G+ D     R      D        
Sbjct: 2063 EDVISHKGDLRYITISGNRVLEAAKSC---SKRDGGKVDTSATHREVQRKLDHATDRFRS 2119

Query: 497  AYVK--LTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
             Y K  +  N +K+    +   E     L   L     +   ++++          L   
Sbjct: 2120 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC--EATASKHLSEPIAVDPKNLQRQ 2177

Query: 555  YKGYMKLLGECSSSIDSVKRL----EHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 610
             +    L G+ SS   +V++L    E  L      LP   ++  T     G   R+E L 
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG---RYEDLS 2234

Query: 611  AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL-STDIQTIELQIKK 669
                 +  +++  L +       L+ +  W+G+ E  L++  ++ L ST +Q I   I K
Sbjct: 2235 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISK 2291

Query: 670  LKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 728
               L++ +  R++ I ++N    +F +  D   +  LQ ++  ++ R+       +E   
Sbjct: 2292 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2351

Query: 729  LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI-VP-IDSNLDAEILQDHHKQLMQIKH- 785
             +++   + + F  +S  L   LE   +   E+ VP  D    ++ +Q+   + ++ K  
Sbjct: 2352 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 2411

Query: 786  -ELLESQLRVASLQDMSCQLLVNAEGTDCL------------EAKEKVHVIGNRL---KL 829
             E+L S L+  S   +     +  E T+ L            E KE V     +L   ++
Sbjct: 2412 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 2471

Query: 830  LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCS 889
            L+K +   IKE  K + +   Q    +      L+ +  +       TP  QK      S
Sbjct: 2472 LVKSLKSWIKETTKKVPI--VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2529

Query: 890  LSQPGPSVSSP 900
            L     +V++P
Sbjct: 2530 LCNLISAVTTP 2540



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 149/753 (19%), Positives = 298/753 (39%), Gaps = 117/753 (15%)

Query: 171  SRFEDWLKSSERTAAFPSSS--------GVIYTVAKEELKKFEAFQRQVHECLTQLELIN 222
            SRFED+L+ S+ +  F  S          V     +E LK  E  + +  E +  L +  
Sbjct: 1192 SRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE--REEQEESVYNLYISE 1249

Query: 223  KQYRRLARENRTDSACSLKQMVHEGNQRWDNL-----QKRVTSILRRLKHFIG----QRE 273
             +  RL  EN  D      +   E +   +++     Q+++   L RLK  +G    + E
Sbjct: 1250 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1309

Query: 274  EF---ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 330
            EF     A  S+    +E+++ L N+           I +LK     +  N    E ++ 
Sbjct: 1310 EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMS-STYIDKLKTVNLVLK-NTQAAEALVK 1367

Query: 331  QGEQLIEKSEPL--DAAIIEEELDELRRYCQEVFGRVERYH---KKLIRLPLPDDEHDLS 385
              E  + + E +  D   IE  +  L+++  EV  + + +H    +L +     DE   +
Sbjct: 1368 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1427

Query: 386  DRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS-ERSGRDTPASVDSI- 443
             +E +L       D  WH   AD L+  +   N+ + +   LR  E  G+      D+  
Sbjct: 1428 YKERDL-------DFDWHKEKADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1478

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            PL+     D  + +E+   +   ++ E  +       +  + +S++ + +S     +   
Sbjct: 1479 PLD-----DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1533

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDS---RFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
                 T  D+       R +  +   S   R ++Q + ++I  +     +L T Y   + 
Sbjct: 1534 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF---MDLRTRYTALVT 1590

Query: 561  LLGE-CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRW------ELLQAQA 613
            L+ +    + DS+KRLE    EEE+SL      H    + A  + +W       L  A+ 
Sbjct: 1591 LMTQYIKFAGDSLKRLE----EEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEK 1643

Query: 614  LSKELRMKQNLQ------KWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE--- 664
              K    KQ +       K +Q +  L +I  +L    +++   +R EL   ++T++   
Sbjct: 1644 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESY 1703

Query: 665  --LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCS 721
              L  + LK+LQ++                  T  D K E + + +R  +   +   +C 
Sbjct: 1704 NLLFSESLKQLQESQ-----------------TSGDVKVEEKIVAERQQEYKEKLQGICD 1746

Query: 722  LLEEWRG---------LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            LL +            ++ D  ++ + +      L   ++   +   E+V    N     
Sbjct: 1747 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN----F 1802

Query: 773  LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            L+++ ++L Q    L+E +L  A ++   C+ L        L+A++    +   +   +K
Sbjct: 1803 LKENGEKLSQEDKALIEQKLNEAKIK---CEQL-------NLKAEQSKKELDKVVTTAIK 1852

Query: 833  EVSRHIKELEKLLDVSSSQQDLSSWSSADELDT 865
            E +  +  +++L +  +  ++L  W S  + D+
Sbjct: 1853 EETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1885



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 119/677 (17%), Positives = 261/677 (38%), Gaps = 100/677 (14%)

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            D + D  ++    L  RW+N+      R   +E   +  + + D Y   +DW++  E T 
Sbjct: 1432 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1491

Query: 185  A-----FPSSSGVIYTVAKEE---LKKFEAFQRQVHEC----------LTQLELINKQYR 226
                   P +S  + T   ++   + + E  Q ++ EC          +   EL    YR
Sbjct: 1492 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1551

Query: 227  RLARENRTDSACSLKQMVHEGN---QRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 283
             +  +++  S    ++M    +   Q + +L+ R T+++  +  +I      + A DS+ 
Sbjct: 1552 AMV-DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI------KFAGDSL- 1603

Query: 284  VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 343
                    +L   E   E + +  +++ K  Q+ +S     ++     G+    K +   
Sbjct: 1604 -------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK--- 1653

Query: 344  AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 403
              I  EE+   +    E    ++ +  K       ++ ++L  +   L++S  L      
Sbjct: 1654 --ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL----LF 1707

Query: 404  DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD-----HDYDLSRDLE 458
              S   L   Q S ++ +        ++  ++    +  +  + +     H         
Sbjct: 1708 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1767

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
            +   +   S+ EE Q D       A  L++V+  ++ E ++K  EN  K +  D + +E 
Sbjct: 1768 TVELKKYQSKQEELQKDMQ---GSAQALAEVV--KNTENFLK--ENGEKLSQEDKALIEQ 1820

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++ +     +    + +Q++           ELD   K     + E +  + +VK+LE  
Sbjct: 1821 KLNEAKIKCEQLNLKAEQSKK----------ELD---KVVTTAIKEETEKVAAVKQLEES 1867

Query: 579  LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL--NS 636
             K + E+L  +++    +++ AG   +  + Q     +E   K  + +  + N +L    
Sbjct: 1868 -KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1926

Query: 637  IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKAIILSIN----LCS 691
            +   +G T+E L Q               Q +K+K + +K +   +A+I++      L  
Sbjct: 1927 VDGQVGTTQENLNQ---------------QYQKVKAQHEKIISQHQAVIIATQSAQVLLE 1971

Query: 692  PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL---LQDALMQCQG-FHEMSHGL 747
             +      +E   LQ  + ++   ++   +  E+   L   LQ+ L +    + E  H L
Sbjct: 1972 KQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWL 2031

Query: 748  LLM---LENIDRRKNEI 761
                  LEN++   ++I
Sbjct: 2032 QQSEQELENLEAGADDI 2048



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 61/327 (18%), Positives = 134/327 (40%), Gaps = 36/327 (11%)

Query: 499  VKLTENAIKNTSGDHSALESQI-----RQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 553
            +++ +  +K++  D +  E +I     + L   +D+ + Q+ +TE    S  P+      
Sbjct: 760  MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE--WGSDLPSVESHLE 817

Query: 554  SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 613
            ++K   + + E  SS+      E K+ E + + P        +   A  + R E   A+ 
Sbjct: 818  NHKNVHRAIEEFESSLK-----EAKISEIQMTAP-------LKLTYAEKLHRLESQYAKL 865

Query: 614  LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-- 671
            L+     +++L     F S   +   WL + EEE       E++ D       I + K  
Sbjct: 866  LNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE-------EVAYDWSERNTNIARKKDY 918

Query: 672  --ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 729
              EL + +D ++  I S+   + +    +      ++   + M  +W  +  L +     
Sbjct: 919  HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 978

Query: 730  LQDALMQCQGFHEMSHG--LLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 787
            +++     + F++       L  L++  +RK      D +     L+D  ++ M+ K EL
Sbjct: 979  IKENTAYFEFFNDAKEATDYLRNLKDAIQRK---YSCDRSSSIHKLEDLVQESMEEKEEL 1035

Query: 788  LESQLRVASLQDMSCQLL-VNAEGTDC 813
            L+ +  +A+L   +  ++ +    +DC
Sbjct: 1036 LQYKSTIANLMGKAKTIIQLKPRNSDC 1062


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  126 bits (316), Expect = 1e-28
 Identities = 163/868 (18%), Positives = 352/868 (40%), Gaps = 63/868 (7%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q    + ++ 
Sbjct: 4135 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVF 4194

Query: 61   TWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
             W+     +LA   PI  D    E +++++ E ++ + +  +    +  + +  E+LL  
Sbjct: 4195 DWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK 4251

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                  +++  ++Q     L   W ++    + R+ K+E       +F         WL 
Sbjct: 4252 V---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLT 4308

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   +     G      + EL K    Q  V    + +E +NK    L   +  + A 
Sbjct: 4309 HTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEAS 4368

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
            +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ +  L   + 
Sbjct: 4369 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4428

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEELDELR 355
                   AK +QL    +  +    K E    ++ +G+Q++ +        I+++++ L+
Sbjct: 4429 LGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4487

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL-LSPQ 414
               + V                   E  L++R+ +LE++  L+ + +H+   D +    Q
Sbjct: 4488 EKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFINWLTQ 4527

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
                L+++    L            +D++  + D     + ++ S   + +   D+ G  
Sbjct: 4528 AEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQII-ELDKTGTH 4575

Query: 475  DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
             K F  +  V L   ++      + K+ +  ++       A   + +Q  +A       +
Sbjct: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAWSKLMEWL 4634

Query: 535  QQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 588
            +++E  + S+     + D        +K + K LG   S  D+  R    LKE+      
Sbjct: 4635 EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADD 4694

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 648
             + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL   E +L
Sbjct: 4695 NLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4751

Query: 649  EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
             + Q   +  DI  +   I   K  QK +  R + + ++   + E  +    +S  ++ +
Sbjct: 4752 AEDQ--PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4809

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDS 766
            + +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R + ++P D 
Sbjct: 4810 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4869

Query: 767  NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 826
            +     L D HK+ M+   +L E +  +     M   +L           K  + +I  R
Sbjct: 4870 DA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925

Query: 827  LKLLLKEVSRHIKELEKLLDVSSSQQDL 854
             + +L    +H + L   L    ++Q+L
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQEL 4953



 Score =  120 bits (301), Expect = 6e-27
 Identities = 169/880 (19%), Positives = 375/880 (42%), Gaps = 101/880 (11%)

Query: 1    MGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            +G+ L +++ +S +++ +E+ L  VN RW+ L   +A R  +L+E L+   +    + SL
Sbjct: 3259 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3318

Query: 60   RTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
             +W+   E  +A  KP    S   + ++ ++ EQ+ LQR ++   + V       EV+  
Sbjct: 3319 LSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKR 3368

Query: 118  DCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
            + +  AT AE  D ++  +    LD RW  +   +  R  ++E    + Q+F +      
Sbjct: 3369 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3428

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINKQYRRLARE 231
            +WL + E+        G   +  +E++ + +A +  +   ++ L Q   I +  + L+  
Sbjct: 3429 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR 3488

Query: 232  NRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
               D    + Q   + +Q W   +Q++  S    L+  +   + F      ++ WL E+ 
Sbjct: 3489 EDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3544

Query: 291  LQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
             +L+  +++ +S   +  +  +L+  Q++I L    ++Q +  G +L++++   +  II+
Sbjct: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-----WH 403
            ++L+ ++   +++               L  D     ++ L+L  +  L   H     W 
Sbjct: 3605 DKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHSTHEELCTWL 3649

Query: 404  DRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            D+    LLS +         S +  +P   ++  ++  A +DS+            ++ S
Sbjct: 3650 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-----------NEVSS 3698

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
            A+   +P    EG +               M+ E  E Y +L  + I     +  A   +
Sbjct: 3699 ALLELVPWRAREGLEK--------------MVAEDNERY-RLVSDTITQKVEEIDAAILR 3743

Query: 520  IRQLGKALDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSV 572
             +Q  +A D     I +TE  + S       +  T  +L       M++L      ID +
Sbjct: 3744 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDL 3802

Query: 573  KRLEHKL----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQ 628
             +  HK+     EEE+         S + +   V+  ++ +      + L++++      
Sbjct: 3803 VKSGHKIMTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            QF      +W WL +T+  + QL    L  + +T+  Q ++ ++L++ +   K  I  +N
Sbjct: 3855 QFWETYEELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMN 3912

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
               P+  +    E   +Q++    +  + ++   +++    L +A+ Q   FH+    +L
Sbjct: 3913 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 3972

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              LE I  R  +  P   + + E +++   +   +  ++ + Q    +L+    +++  +
Sbjct: 3973 ESLERIVERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4030

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 847
             GTD   + + V    +++  + + +   ++E E KLLDV
Sbjct: 4031 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 4070



 Score =  104 bits (260), Expect = 4e-22
 Identities = 179/900 (19%), Positives = 361/900 (40%), Gaps = 106/900 (11%)

Query: 39   VKKLKETLVAVQ-QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 94
            +K+ KE + + Q QLD     + SL++W+     ++  PIV  S  +E++ + L + ++L
Sbjct: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKL 2331

Query: 95   QR-------DIEKHSTGVASVLNLCEVLLHDCDACA---------------TDAE----- 127
            Q        +I+K +    S+ NL   +     A A               T+ E     
Sbjct: 2332 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2391

Query: 128  --CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
                SI++   ++   + ++  +  ++  ++       QK  ++ S    WL+   +TA 
Sbjct: 2392 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2451

Query: 186  -FPSSSGVIYTVA-KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQ 242
             +  +     T A K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQ
Sbjct: 2452 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2511

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 302
            M+ E + +W  L +      ++L+       +F+T    +  WL E +L ++ +   S  
Sbjct: 2512 MLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSID 2571

Query: 303  D--VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYC 358
               +  + +Q++   QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +  
Sbjct: 2572 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2631

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
              + G++      + +  +   ++    R L    S  LSDL     S+ ++ +   + N
Sbjct: 2632 DSLTGQLSDRCDWIDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMN 2687

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDK 476
              L  AQ ++ E         V     E     DLS  ++    +A  S   EG  +  K
Sbjct: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFK 2742

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQ 533
            D             + +  E +V+  ++A         A   Q +Q+ +      D++ +
Sbjct: 2743 D-------------VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKE 2781

Query: 534  IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNL 592
             Q   + I +K      L   +K + K L   S   + ++   E+ L + + S    + L
Sbjct: 2782 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2841

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +T      W+    Q   +E ++K++L+K  ++   + ++W W+   +  LE+  
Sbjct: 2842 QLNTIKT-----NWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-- 2894

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             ++   D    E  I KLK LQK +D    ++  +N  +         +   + D    +
Sbjct: 2895 -IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSL 2953

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNL 768
              + D V   L   +  L++   + + F E+S      L    E +D   +      SN 
Sbjct: 2954 IQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3013

Query: 769  DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
               +LQ   K L  +KH++    L     QD+  +   +++GT   +   +V  I     
Sbjct: 3014 YLTMLQTQQKSLQALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHS 3067

Query: 829  LLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 882
             L ++V      LE KL  +   Q  +    S      DELD+   V    GR     QK
Sbjct: 3068 TLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3123



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 166/889 (18%), Positives = 342/889 (38%), Gaps = 95/889 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES----ELA 71
            E++ KL    DR++ L          LK+ +   Q  +     L   L   E+     L+
Sbjct: 1927 EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS 1986

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +PI  D  N   +QR+L E + LQ  I      V  +    EVLL D       A+ D I
Sbjct: 1987 EPIAVDPKN---LQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-DARGSLLPAKND-I 2041

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 191
            Q+   ++  R+ ++     ER  K++ T        D      DW+ + E +        
Sbjct: 2042 QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVP 2101

Query: 192  VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRW 251
            +  T  ++ + K    ++ +    + +  +N++ ++        +A SL+  + + + R+
Sbjct: 2102 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARF 2161

Query: 252  DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-IKQ 310
                 +    L +++    + E FE   + +  +L       T  +  +E DV  K + +
Sbjct: 2162 SEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE------TKTQALTEVDVPGKDVTE 2215

Query: 311  LKAFQQEIS---LNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRR---------- 356
            L  + QE +   L H K +E + +  +++     P D A++ E+ + L +          
Sbjct: 2216 LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK 2275

Query: 357  -------YCQEVFGRVERYHKKL--------IRLPLPDDEHDLSDRELELEDSAALSDLH 401
                    CQE     +   K L         ++P+        D    LED+  L +  
Sbjct: 2276 EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE-K 2334

Query: 402  WHDRSADSLLSP--QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            W      SL +P  Q  +N  +SL   + +  +     A+V S     + +   +   E 
Sbjct: 2335 W------SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2388

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
              ++ L S  ++  D    Y    + L D           K+ E            L ++
Sbjct: 2389 WANKGLTSIKKDMTDISHGYEDLGLLLKD-----------KIAE------------LNTK 2425

Query: 520  IRQLGKALDDSRFQIQQTENIIRSKT-------PTGPE-LDTSYKGYMKLLGECSSSIDS 571
            + +L KA ++S   +Q  + + ++ T       PT  E + T  +       E   +++ 
Sbjct: 2426 LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2485

Query: 572  VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFN 631
            V+ L+ KL E  E  P        +     +  +W+ L    + ++ +++++     QF 
Sbjct: 2486 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2545

Query: 632  SDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCS 691
            +    +  WL   E+EL       LS D   +  Q ++++ L +    RK     +    
Sbjct: 2546 TVEAQLKQWL--VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2603

Query: 692  PEFTQADSKESR---DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                    ++      ++++L+ +  +WD +   L +    +  A+++   +  +   L 
Sbjct: 2604 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2663

Query: 749  LMLENIDRRKNEIVPIDSNLDA--EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV 806
              L ++D + +  + + ++ DA  + L+   K   +I+ E  + ++  A  +D+S   LV
Sbjct: 2664 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA--LV 2721

Query: 807  NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 855
              E     E   ++  I    K + ++   H++ L+     S   Q +S
Sbjct: 2722 KEEYLKA-ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 158/857 (18%), Positives = 337/857 (39%), Gaps = 75/857 (8%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES--ELAKPI 74
            I+  L  ++ +   LLD   AR ++++ T+  +++    +      L   E   E   P+
Sbjct: 3165 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV 3224

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
                  +E I ++LN  +  Q++  +   G    +N     L    A +T  +   ++  
Sbjct: 3225 ---GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHD 3279

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 194
              +++ RW+ +     +R  +++E      +F D       W+  +E   A        +
Sbjct: 3280 LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF 3339

Query: 195  TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 254
             V K ++++ +  QR + +  + +E+I ++  ++A          + + +   + RW+ L
Sbjct: 3340 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3399

Query: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLK 312
              +  +  R+L+      ++F    + +  WLT ++ +L N E        ++ +I Q K
Sbjct: 3400 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3459

Query: 313  AFQQEISLNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV----FGRVER 367
            A + +I +NHNK + Q ++ G+ L   S   D  +++ +LD  + +  E+      R E 
Sbjct: 3460 ALEDDI-INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518

Query: 368  YHKKLIRLPL-PDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
              + L    +  +DE +L +   E+ D   LS L   D S + L   Q    +       
Sbjct: 3519 LQQALCNAKIFGEDEVELMNWLNEVHDK--LSKLSVQDYSTEGLWKQQSELRV------- 3569

Query: 427  LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
                          D +  + + D  L   LE                     L+   G 
Sbjct: 3570 -----------LQEDILLRKQNVDQALLNGLE--------------------LLKQTTGD 3598

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-----QQTENII 541
              ++I +  EA +K     I   S D +    Q  QL + L  +  ++     +    ++
Sbjct: 3599 EVLIIQDKLEA-IKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELL 3657

Query: 542  RSKTPT--GPELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              +T    G E   +     +L  E  ++   +DS+  +   L E    L  +      E
Sbjct: 3658 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE----LVPWRAREGLE 3713

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
               A   +R+ L+      K   +   + + QQF+   ++  +W+ +TE++L  L  + L
Sbjct: 3714 KMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3773

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
              D  + +LQ++K   ++  + H+  I   +       T    +E + ++ +L ++   +
Sbjct: 3774 EQDQTSAQLQVQKTFTME-ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3832

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            D +C +  E    L+ A      F E    L   L       +++ P  + L+ E L+  
Sbjct: 3833 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL-PAPA-LEYETLRQQ 3890

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++  Q++  + E +  +  +     QLL  + G +    +EK          + ++V +
Sbjct: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG-EGFSIQEKYVAADTLYSQIKEDVKK 3949

Query: 837  HIKELEKLLDVSSSQQD 853
                L++ +  S+   D
Sbjct: 3950 RAVALDEAISQSTQFHD 3966



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 152/877 (17%), Positives = 347/877 (39%), Gaps = 83/877 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE++A  +  +   +I  +L  ++ RW+ LL+    R ++L+   V  QQ  + +  L  
Sbjct: 3370 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3429

Query: 62   WLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            WL  IE  L   +PI      + +++ ++ + + L+ DI  H+  +   +++ + L    
Sbjct: 3430 WLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL---- 3482

Query: 120  DACATDAECDSIQQATRNLDRRWR-NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                +  E   + Q+  +  + W   I   S  R   +++     + F +D     +WL 
Sbjct: 3483 -KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3541

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY--------RRLAR 230
                  +  S    +   + E L K ++  R + E +    L+ KQ           L +
Sbjct: 3542 EVHDKLSKLS----VQDYSTEGLWKQQSELRVLQEDI----LLRKQNVDQALLNGLELLK 3593

Query: 231  ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
            +   D    ++  +     R+ ++ K  T + + L+  +       +  + +  WL +++
Sbjct: 3594 QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE 3653

Query: 291  LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
            ++L + E       +A   Q++  + +    +NK          L++    + +A++E  
Sbjct: 3654 VELLSYETQVLKGEEASQAQMRPKELKKEAKNNK---------ALLDSLNEVSSALLELV 3704

Query: 351  LDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADS 409
                R   +++     ERY  +L+         D   +++E  D+A L    + D++AD+
Sbjct: 3705 PWRAREGLEKMVAEDNERY--RLV--------SDTITQKVEEIDAAILRSQQF-DQAADA 3753

Query: 410  LLSPQPSSNLSLSLAQPLRSERSGRDTPASVD-SIPLEWDHDYDLSRDLESAMSRALPSE 468
             LS    +   L     +R E+        V  +  +E     D+  DL  +  + + + 
Sbjct: 3754 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3813

Query: 469  DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD 528
             EE +      L   +   D +   + E Y++L               +S + Q  +  +
Sbjct: 3814 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQL------------ERAQSLVNQFWETYE 3861

Query: 529  DSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +    + +T++II        E +T       ++   +L+ E    ID + +   +L E 
Sbjct: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3921

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                 GF    S + +       +  ++     + + + + + +  QF+  ++ I   L 
Sbjct: 3922 SPG-EGF----SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LE 3973

Query: 643  DTEEELEQL-QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
              E  +E+L Q   +S +++ I+ QI + K +   ++  + +  ++     E        
Sbjct: 3974 SLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 4033

Query: 702  SRDL-----QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
             +D+     QD+L QM   W+ + +L+EE    L D +   + F      L++ +++   
Sbjct: 4034 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 4093

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
               ++   D  +D  +++   +    I+ E+   Q  +  + ++  +L+      D    
Sbjct: 4094 FIRDLE--DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4151

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
            K+ +  + +    L K     I +LE+ +  +   QD
Sbjct: 4152 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 73/379 (19%), Positives = 169/379 (44%), Gaps = 17/379 (4%)

Query: 3    ERLAKASHESK---ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            E +A++    K   A  ++ KL ++   W+++  L+  R  KL + +   ++   +  SL
Sbjct: 4025 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4084

Query: 60   RTWLAHIES---ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 116
               +   +    +L  P +  S         + +QQE    I +   G+   L++   L 
Sbjct: 4085 IVTIKDTQDFIRDLEDPGIDPSV--------VKQQQEAAETIREEIDGLQEELDIVINLG 4136

Query: 117  HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 176
             +  A   + +   ++++   L+  W ++     +R  K+EE  +   ++ D      DW
Sbjct: 4137 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4196

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            +  +    A  S  G      K+++++ + F+ + ++   ++E +N Q   L ++   +S
Sbjct: 4197 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEES 4256

Query: 237  -ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
               +++  + E    WD+L++R+ +   +L+  +    +F+ A D +L WLT  +  L+ 
Sbjct: 4257 DKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE 4316

Query: 296  IEHFSECDVQAKIKQLK--AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             +         +I+  K    Q ++  + + +E +   G  LIE S   +A+ ++ +L+ 
Sbjct: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEV 4376

Query: 354  LRRYCQEVFGRVERYHKKL 372
            L +  Q V  + E+  ++L
Sbjct: 4377 LNQRWQNVLEKTEQRKQQL 4395



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 168/922 (18%), Positives = 348/922 (37%), Gaps = 106/922 (11%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L   +  S+ + ++ +L  +   W      +  R  KLKE+L    +  + + +L  
Sbjct: 2824 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 2883

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD- 120
            W+   ++ L +  +    +  E +  + + + LQ+++++H   V  + N    LL  C+ 
Sbjct: 2884 WIDKCQNNLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2941

Query: 121  --ACATDAECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDW 176
                 TD     IQ+     ++   +  C  +M ++ K  +E  +  ++ L       D 
Sbjct: 2942 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 3000

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLT 216
            +  S  + A+   S    T+ + + K  +A + QV                     + L 
Sbjct: 3001 IHDSLGSQAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057

Query: 217  QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE 276
            Q+E I +++  L+++   D  CS  +   +G   + N           ++    Q  EF+
Sbjct: 3058 QVETIAQEHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFD 3105

Query: 277  TARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLI 336
               DS    +  +      ++   E  ++A +K+L+A        +   + ++A      
Sbjct: 3106 DELDS----MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----T 3155

Query: 337  EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 396
            E++ P D   I+ +L+ L + C ++  R +   +++       +E     +E     S  
Sbjct: 3156 EETSP-DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SIL 3210

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
            L     H+ S   +     + N  L++ +  + E      P       + W     L + 
Sbjct: 3211 LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQG 3262

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
            L  + +++  ++  E              L DV       A  K     +   +      
Sbjct: 3263 LIQSAAKSTSTQGLEHD------------LDDV------NARWKTLNKKVAQRAAQLQEA 3304

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSID 570
                 +   AL+     +  TE ++ ++ P   E           K   +LL +  S+++
Sbjct: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364

Query: 571  SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 630
             +KR   K+    E       L     Q + +  RWE L  +A ++  +++      QQF
Sbjct: 3365 VIKREGEKIATTAEPADKVKIL----KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3420

Query: 631  NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINL 689
            +  L  +  WL   E+ L   +   + T    +E QI + K L+   ++H K +  ++++
Sbjct: 3421 HETLEPLNEWLTTIEKRLVNCE--PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI 3478

Query: 690  CSPEFTQADSKESRDL-QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                     S+E +D+ Q +L      +  +         LLQ AL   + F E    L+
Sbjct: 3479 -GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              L  +  + +++   D     E L     +L  ++ ++L  +  V        +LL   
Sbjct: 3538 NWLNEVHDKLSKLSVQD--YSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADELD 864
             G + L  ++K+  I  R K + K  +   K LE+ L ++    S+ ++L +W    E++
Sbjct: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655

Query: 865  -TSGSVSPTSGRSTPNRQKTPR 885
              S       G      Q  P+
Sbjct: 3656 LLSYETQVLKGEEASQAQMRPK 3677



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 162/881 (18%), Positives = 342/881 (38%), Gaps = 71/881 (8%)

Query: 6    AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 65
            A+ S     ++I+  L  +  R++ L   +  R +KL+ TL     +   +  +  W+ +
Sbjct: 2030 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 2089

Query: 66   IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            +ES L K       NS  +Q  +++   L++DI    + + ++    +  +   D     
Sbjct: 2090 VESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD----P 2144

Query: 126  AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            +   S+Q   ++L  R+        E   K+EE     + F +   + + +L++  +   
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204

Query: 186  FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                 G   T   + +++  +   +  E    LE+++   + ++          + +  +
Sbjct: 2205 EVDVPGKDVTELSQYMQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTN 2261

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDV 304
              ++++  ++  +      +     Q + F+    S+  W+ E   ++  ++  F   D+
Sbjct: 2262 NLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDL 2321

Query: 305  QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE----KSEPLDAAIIEEELDELRRYCQE 360
               ++  K  Q++ SL   +I+++   G  L       + P  A    +    +      
Sbjct: 2322 GKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGT 2381

Query: 361  VFGRVERYHKK---LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
                 E +  K    I+  + D  H   D  L L+D  A      + + +    + + SS
Sbjct: 2382 ATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA----ELNTKLSKLQKAQEESS 2437

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
             +   L +  ++    + TPA  D+  ++   + + S + E      L     + Q+ KD
Sbjct: 2438 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE------LKQNVNKVQELKD 2491

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ---- 533
                      D   PE+P     LTE   K    +   ++ Q +    + + ++FQ    
Sbjct: 2492 KLTELLEENPDT--PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2549

Query: 534  -----IQQTENIIRSKTPTGPE---LDTSYKGYMKLLGECSSSIDSVKRLEH------KL 579
                 + + E ++    P   +   L+T  +    LL E ++     ++L          
Sbjct: 2550 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2609

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
              E+ SL G V     + Q A V  +W+ L  Q   +   + Q + K  Q+ S L S+  
Sbjct: 2610 PGEDPSLRGIV-----KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2664

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV-DHRKAIILSINLCSPEFTQAD 698
             L D + +L     L +ST    +  Q++  +++++ +   +K I ++  LC  E   A 
Sbjct: 2665 KLSDLDNKLS--SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC--EDLSAL 2720

Query: 699  SKE---SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
             KE     +L  +L  +   +  V    E     LQ A      F +MS      L+   
Sbjct: 2721 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780

Query: 756  RRKNEIVPIDSNLDA--EILQDH---HKQLMQIKH----ELLESQ---LRVASLQDMSCQ 803
              +N+  PI + LD    +++DH    K L    H     + E +   L+    +  + Q
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840

Query: 804  LLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 844
            L +N   T+     ++V    N+LK  L++  ++ +++E L
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2881



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 162/891 (18%), Positives = 354/891 (39%), Gaps = 104/891 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            K  ++ +RWQ++   I  R++ L+    +++        L  W+  +E+   K       
Sbjct: 1263 KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 1322

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            NS+ +  +LN+Q+ L  +IE       S ++ C+       A   D E  ++      +D
Sbjct: 1323 NSKTLATQLNQQKMLVSEIEMKQ----SKMDECQKYAEQYSATVKDYELQTMTYRAM-VD 1377

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             + ++     ++RR        + Q+F+D  +R+   +    +   F   S  +  + +E
Sbjct: 1378 SQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEE 1431

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVT 259
            E    E  +  V +     + ++   + L    +       KQ +   ++     +++++
Sbjct: 1432 EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI--SSEEISTKKEQLS 1489

Query: 260  SILRRLKHFIG---------QREEFE----TARDSILVWLTEMDLQLTNIEHFSECDVQA 306
              L+ ++ F+          +R E E    T ++S  +  +E   QL   +   +  V+ 
Sbjct: 1490 EALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEE 1549

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC--QEVFGR 364
            KI   +  QQE       I  ++ Q E  +   +  +A +I +   EL++Y   QE   +
Sbjct: 1550 KIVAER--QQEYKEKLQGICDLLTQTENRLIGHQ--EAFMIGDGTVELKKYQSKQEELQK 1605

Query: 365  VERYHKKLIRLPLPDDEHDLSDRELEL-EDSAALSDLHWHDRSAD----SLLSPQPSSNL 419
              +   + +   + + E+ L +   +L ++  AL +   ++        +L + Q    L
Sbjct: 1606 DMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL 1665

Query: 420  SLSLAQPLRSE-------RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
               +   ++ E       +   ++   ++++ L+W  + D  +D E A ++     ++ G
Sbjct: 1666 DKVVTTAIKEETEKVAAVKQLEESKTKIENL-LDWLSNVD--KDSERAGTKHKQVIEQNG 1722

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRF 532
               ++   + A+G       E  E    L E  +    G      +Q  Q  KA      
Sbjct: 1723 THFQEGDGKSAIG-------EEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA------ 1769

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
               Q E II                   ++   S+ +   K+ ++   EE+E L   +  
Sbjct: 1770 ---QHEKIISQHQAV-------------IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1813

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +TA      ++    +L +EL         ++F++D      WL  +E+ELE L+
Sbjct: 1814 LKVHYETALAESEKKMKLTHSLQEEL---------EKFDADYTEFEHWLQQSEQELENLE 1864

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA-------------DS 699
                + DI  +  ++K+ K   + V   K  +  I +      +A              S
Sbjct: 1865 --AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTS 1922

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
               R++Q +L     R+  + S        L+D + + Q + + S GLL  L+  +   +
Sbjct: 1923 ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS 1982

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 819
            + +     +D + LQ   ++   ++ ++   Q+ V  L+  + ++L++A G+  L AK  
Sbjct: 1983 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK-KTAEVLLDARGS-LLPAKND 2040

Query: 820  VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE-LDTSGSV 869
            +    + +    +++S+ + E  + L ++ + + LS     DE LD  G+V
Sbjct: 2041 IQKTLDDIVGRYEDLSKSVNERNEKLQITLT-RSLSVQDGLDEMLDWMGNV 2090



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 188/971 (19%), Positives = 363/971 (37%), Gaps = 161/971 (16%)

Query: 43   KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 102
            KE +   ++L K +S++   L   E     P      +SEEI  K  +  E         
Sbjct: 1440 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--------- 1490

Query: 103  TGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR--------L 154
                  L   ++ L       TD E + +++  + L   +  + + S+++         +
Sbjct: 1491 -----ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1545

Query: 155  KIEE--TWRLWQKFLDDYSRFEDWLKSSERTA-----AFPSSSGVIYTVAKEELKKFEAF 207
            K+EE       Q++ +      D L  +E        AF    G +      ELKK+++ 
Sbjct: 1546 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV------ELKKYQSK 1599

Query: 208  QRQVH-------ECLTQL------------ELINKQYRRLARENRTDSACSLKQMVHEGN 248
            Q ++        + L ++            E ++++ + L  +   ++    +Q+  +  
Sbjct: 1600 QEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAE 1659

Query: 249  QRWDNLQKRVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLT----------- 294
            Q    L K VT+ ++     +    Q EE +T  +++L WL+ +D               
Sbjct: 1660 QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1719

Query: 295  -NIEHFSECDVQAKIK----------------QLKAFQQEISLNHNKI----EQIIAQ-- 331
             N  HF E D ++ I                 Q+   Q+ ++  + K+    E+II+Q  
Sbjct: 1720 QNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQ 1779

Query: 332  --------GEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD 379
                     + L+EK      P +   +++ + EL+ + +      E+  K         
Sbjct: 1780 AVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT------- 1832

Query: 380  DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 439
              H L + ELE  D+      HW  +S   L + +  ++    L   L+ ++S      S
Sbjct: 1833 --HSLQE-ELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS-----FS 1884

Query: 440  VDSIPLEWDHDYDL---SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
             D I  + D  Y     +R LE+A S    S+ + G+ D     R      D        
Sbjct: 1885 EDVISHKGDLRYITISGNRVLEAAKSC---SKRDGGKVDTSATHREVQRKLDHATDRFRS 1941

Query: 497  AYVK--LTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
             Y K  +  N +K+    +   E     L   L     +   ++++          L   
Sbjct: 1942 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC--EATASKHLSEPIAVDPKNLQRQ 1999

Query: 555  YKGYMKLLGECSSSIDSVKRL----EHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 610
             +    L G+ SS   +V++L    E  L      LP   ++  T     G   R+E L 
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG---RYEDLS 2056

Query: 611  AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL-STDIQTIELQIKK 669
                 +  +++  L +       L+ +  W+G+ E  L++  ++ L ST +Q I   I K
Sbjct: 2057 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISK 2113

Query: 670  LKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 728
               L++ +  R++ I ++N    +F +  D   +  LQ ++  ++ R+       +E   
Sbjct: 2114 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2173

Query: 729  LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI-VP-IDSNLDAEILQDHHKQLMQIKH- 785
             +++   + + F  +S  L   LE   +   E+ VP  D    ++ +Q+   + ++ K  
Sbjct: 2174 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 2233

Query: 786  -ELLESQLRVASLQDMSCQLLVNAEGTDCL------------EAKEKVHVIGNRL---KL 829
             E+L S L+  S   +     +  E T+ L            E KE V     +L   ++
Sbjct: 2234 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 2293

Query: 830  LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCS 889
            L+K +   IKE  K + +   Q    +      L+ +  +       TP  QK      S
Sbjct: 2294 LVKSLKSWIKETTKKVPI--VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2351

Query: 890  LSQPGPSVSSP 900
            L     +V++P
Sbjct: 2352 LCNLISAVTTP 2362



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 149/753 (19%), Positives = 298/753 (39%), Gaps = 117/753 (15%)

Query: 171  SRFEDWLKSSERTAAFPSSS--------GVIYTVAKEELKKFEAFQRQVHECLTQLELIN 222
            SRFED+L+ S+ +  F  S          V     +E LK  E  + +  E +  L +  
Sbjct: 1014 SRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE--REEQEESVYNLYISE 1071

Query: 223  KQYRRLARENRTDSACSLKQMVHEGNQRWDNL-----QKRVTSILRRLKHFIG----QRE 273
             +  RL  EN  D      +   E +   +++     Q+++   L RLK  +G    + E
Sbjct: 1072 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1131

Query: 274  EF---ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 330
            EF     A  S+    +E+++ L N+           I +LK     +  N    E ++ 
Sbjct: 1132 EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMS-STYIDKLKTVNLVLK-NTQAAEALVK 1189

Query: 331  QGEQLIEKSEPL--DAAIIEEELDELRRYCQEVFGRVERYH---KKLIRLPLPDDEHDLS 385
              E  + + E +  D   IE  +  L+++  EV  + + +H    +L +     DE   +
Sbjct: 1190 LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 1249

Query: 386  DRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS-ERSGRDTPASVDSI- 443
             +E +L       D  WH   AD L+  +   N+ + +   LR  E  G+      D+  
Sbjct: 1250 YKERDL-------DFDWHKEKADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 1300

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            PL+     D  + +E+   +   ++ E  +       +  + +S++ + +S     +   
Sbjct: 1301 PLD-----DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1355

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDS---RFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
                 T  D+       R +  +   S   R ++Q + ++I  +     +L T Y   + 
Sbjct: 1356 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF---MDLRTRYTALVT 1412

Query: 561  LLGE-CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRW------ELLQAQA 613
            L+ +    + DS+KRLE    EEE+SL      H    + A  + +W       L  A+ 
Sbjct: 1413 LMTQYIKFAGDSLKRLE----EEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEK 1465

Query: 614  LSKELRMKQNLQ------KWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE--- 664
              K    KQ +       K +Q +  L +I  +L    +++   +R EL   ++T++   
Sbjct: 1466 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESY 1525

Query: 665  --LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCS 721
              L  + LK+LQ++                  T  D K E + + +R  +   +   +C 
Sbjct: 1526 NLLFSESLKQLQESQ-----------------TSGDVKVEEKIVAERQQEYKEKLQGICD 1568

Query: 722  LLEEWRG---------LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            LL +            ++ D  ++ + +      L   ++   +   E+V    N     
Sbjct: 1569 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN----F 1624

Query: 773  LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            L+++ ++L Q    L+E +L  A ++   C+ L        L+A++    +   +   +K
Sbjct: 1625 LKENGEKLSQEDKALIEQKLNEAKIK---CEQL-------NLKAEQSKKELDKVVTTAIK 1674

Query: 833  EVSRHIKELEKLLDVSSSQQDLSSWSSADELDT 865
            E +  +  +++L +  +  ++L  W S  + D+
Sbjct: 1675 EETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1707



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 119/677 (17%), Positives = 261/677 (38%), Gaps = 100/677 (14%)

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            D + D  ++    L  RW+N+      R   +E   +  + + D Y   +DW++  E T 
Sbjct: 1254 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313

Query: 185  A-----FPSSSGVIYTVAKEE---LKKFEAFQRQVHEC----------LTQLELINKQYR 226
                   P +S  + T   ++   + + E  Q ++ EC          +   EL    YR
Sbjct: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1373

Query: 227  RLARENRTDSACSLKQMVHEGN---QRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 283
             +  +++  S    ++M    +   Q + +L+ R T+++  +  +I      + A DS+ 
Sbjct: 1374 AMV-DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI------KFAGDSL- 1425

Query: 284  VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 343
                    +L   E   E + +  +++ K  Q+ +S     ++     G+    K +   
Sbjct: 1426 -------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK--- 1475

Query: 344  AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 403
              I  EE+   +    E    ++ +  K       ++ ++L  +   L++S  L      
Sbjct: 1476 --ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL----LF 1529

Query: 404  DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD-----HDYDLSRDLE 458
              S   L   Q S ++ +        ++  ++    +  +  + +     H         
Sbjct: 1530 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1589

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
            +   +   S+ EE Q D       A  L++V+  ++ E ++K  EN  K +  D + +E 
Sbjct: 1590 TVELKKYQSKQEELQKDMQ---GSAQALAEVV--KNTENFLK--ENGEKLSQEDKALIEQ 1642

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++ +     +    + +Q++           ELD   K     + E +  + +VK+LE  
Sbjct: 1643 KLNEAKIKCEQLNLKAEQSKK----------ELD---KVVTTAIKEETEKVAAVKQLEES 1689

Query: 579  LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL--NS 636
             K + E+L  +++    +++ AG   +  + Q     +E   K  + +  + N +L    
Sbjct: 1690 -KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1748

Query: 637  IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKAIILSIN----LCS 691
            +   +G T+E L Q               Q +K+K + +K +   +A+I++      L  
Sbjct: 1749 VDGQVGTTQENLNQ---------------QYQKVKAQHEKIISQHQAVIIATQSAQVLLE 1793

Query: 692  PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL---LQDALMQCQG-FHEMSHGL 747
             +      +E   LQ  + ++   ++   +  E+   L   LQ+ L +    + E  H L
Sbjct: 1794 KQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWL 1853

Query: 748  LLM---LENIDRRKNEI 761
                  LEN++   ++I
Sbjct: 1854 QQSEQELENLEAGADDI 1870



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 61/327 (18%), Positives = 134/327 (40%), Gaps = 36/327 (11%)

Query: 499 VKLTENAIKNTSGDHSALESQI-----RQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 553
           +++ +  +K++  D +  E +I     + L   +D+ + Q+ +TE    S  P+      
Sbjct: 582 MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE--WGSDLPSVESHLE 639

Query: 554 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 613
           ++K   + + E  SS+      E K+ E + + P        +   A  + R E   A+ 
Sbjct: 640 NHKNVHRAIEEFESSLK-----EAKISEIQMTAP-------LKLTYAEKLHRLESQYAKL 687

Query: 614 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-- 671
           L+     +++L     F S   +   WL + EEE       E++ D       I + K  
Sbjct: 688 LNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE-------EVAYDWSERNTNIARKKDY 740

Query: 672 --ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 729
             EL + +D ++  I S+   + +    +      ++   + M  +W  +  L +     
Sbjct: 741 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 800

Query: 730 LQDALMQCQGFHEMSHG--LLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 787
           +++     + F++       L  L++  +RK      D +     L+D  ++ M+ K EL
Sbjct: 801 IKENTAYFEFFNDAKEATDYLRNLKDAIQRK---YSCDRSSSIHKLEDLVQESMEEKEEL 857

Query: 788 LESQLRVASLQDMSCQLL-VNAEGTDC 813
           L+ +  +A+L   +  ++ +    +DC
Sbjct: 858 LQYKSTIANLMGKAKTIIQLKPRNSDC 884


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  126 bits (316), Expect = 1e-28
 Identities = 163/868 (18%), Positives = 352/868 (40%), Gaps = 63/868 (7%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q    + ++ 
Sbjct: 3809 LGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVF 3868

Query: 61   TWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
             W+     +LA   PI  D    E +++++ E ++ + +  +    +  + +  E+LL  
Sbjct: 3869 DWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK 3925

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                  +++  ++Q     L   W ++    + R+ K+E       +F         WL 
Sbjct: 3926 V---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLT 3982

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   +     G      + EL K    Q  V    + +E +NK    L   +  + A 
Sbjct: 3983 HTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEAS 4042

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
            +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ +  L   + 
Sbjct: 4043 NLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKP 4102

Query: 299  FSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIEEELDELR 355
                   AK +QL    +  +    K E    ++ +G+Q++ +        I+++++ L+
Sbjct: 4103 LGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLK 4161

Query: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL-LSPQ 414
               + V                   E  L++R+ +LE++  L+ + +H+   D +    Q
Sbjct: 4162 EKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQDFINWLTQ 4201

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
                L+++    L            +D++  + D     + ++ S   + +   D+ G  
Sbjct: 4202 AEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQII-ELDKTGTH 4249

Query: 475  DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
             K F  +  V L   ++      + K+ +  ++       A   + +Q  +A       +
Sbjct: 4250 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAWSKLMEWL 4308

Query: 535  QQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPG 588
            +++E  + S+     + D        +K + K LG   S  D+  R    LKE+      
Sbjct: 4309 EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADD 4368

Query: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 648
             + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL   E +L
Sbjct: 4369 NLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4425

Query: 649  EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
             + Q   +  DI  +   I   K  QK +  R + + ++   + E  +    +S  ++ +
Sbjct: 4426 AEDQ--PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4483

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDS 766
            + +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R + ++P D 
Sbjct: 4484 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4543

Query: 767  NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNR 826
            +     L D HK+ M+   +L E +  +     M   +L           K  + +I  R
Sbjct: 4544 DA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4599

Query: 827  LKLLLKEVSRHIKELEKLLDVSSSQQDL 854
             + +L    +H + L   L    ++Q+L
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQEL 4627



 Score =  120 bits (301), Expect = 6e-27
 Identities = 169/880 (19%), Positives = 375/880 (42%), Gaps = 101/880 (11%)

Query: 1    MGERLAKASHESKASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            +G+ L +++ +S +++ +E+ L  VN RW+ L   +A R  +L+E L+   +    + SL
Sbjct: 2933 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 2992

Query: 60   RTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
             +W+   E  +A  KP    S   + ++ ++ EQ+ LQR ++   + V       EV+  
Sbjct: 2993 LSWMVDTEELVANQKP---PSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKR 3042

Query: 118  DCDACATDAE-CDSIQ--QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
            + +  AT AE  D ++  +    LD RW  +   +  R  ++E    + Q+F +      
Sbjct: 3043 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3102

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV---HECLTQLELINKQYRRLARE 231
            +WL + E+        G   +  +E++ + +A +  +   ++ L Q   I +  + L+  
Sbjct: 3103 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR 3162

Query: 232  NRTDSACSLKQMVHEGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
               D    + Q   + +Q W   +Q++  S    L+  +   + F      ++ WL E+ 
Sbjct: 3163 EDKD----MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3218

Query: 291  LQLT--NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
             +L+  +++ +S   +  +  +L+  Q++I L    ++Q +  G +L++++   +  II+
Sbjct: 3219 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3278

Query: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-----WH 403
            ++L+ ++   +++               L  D     ++ L+L  +  L   H     W 
Sbjct: 3279 DKLEAIKARYKDI-------------TKLSTDVAKTLEQALQL--ARRLHSTHEELCTWL 3323

Query: 404  DRSADSLLSPQ----PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            D+    LLS +         S +  +P   ++  ++  A +DS+            ++ S
Sbjct: 3324 DKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL-----------NEVSS 3372

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
            A+   +P    EG +               M+ E  E Y +L  + I     +  A   +
Sbjct: 3373 ALLELVPWRAREGLEK--------------MVAEDNERY-RLVSDTITQKVEEIDAAILR 3417

Query: 520  IRQLGKALDDSRFQIQQTENIIRS-------KTPTGPELDTSYKGYMKLLGECSSSIDSV 572
             +Q  +A D     I +TE  + S       +  T  +L       M++L      ID +
Sbjct: 3418 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDL 3476

Query: 573  KRLEHKL----KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQ 628
             +  HK+     EEE+         S + +   V+  ++ +      + L++++      
Sbjct: 3477 VKSGHKIMTACSEEEK--------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3528

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            QF      +W WL +T+  + QL    L  + +T+  Q ++ ++L++ +   K  I  +N
Sbjct: 3529 QFWETYEELWPWLTETQSIISQLPAPAL--EYETLRQQQEEHRQLRELIAEHKPHIDKMN 3586

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
               P+  +    E   +Q++    +  + ++   +++    L +A+ Q   FH+    +L
Sbjct: 3587 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 3646

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              LE I  R  +  P   + + E +++   +   +  ++ + Q    +L+    +++  +
Sbjct: 3647 ESLERIVERLRQ--PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 3704

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDV 847
             GTD   + + V    +++  + + +   ++E E KLLDV
Sbjct: 3705 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDV 3744



 Score =  104 bits (260), Expect = 4e-22
 Identities = 179/900 (19%), Positives = 361/900 (40%), Gaps = 106/900 (11%)

Query: 39   VKKLKETLVAVQ-QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 94
            +K+ KE + + Q QLD     + SL++W+     ++  PIV  S  +E++ + L + ++L
Sbjct: 1948 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKL 2005

Query: 95   QR-------DIEKHSTGVASVLNLCEVLLHDCDACA---------------TDAE----- 127
            Q        +I+K +    S+ NL   +     A A               T+ E     
Sbjct: 2006 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2065

Query: 128  --CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
                SI++   ++   + ++  +  ++  ++       QK  ++ S    WL+   +TA 
Sbjct: 2066 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTAT 2125

Query: 186  -FPSSSGVIYTVA-KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQ 242
             +  +     T A K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQ
Sbjct: 2126 KWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQ 2185

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 302
            M+ E + +W  L +      ++L+       +F+T    +  WL E +L ++ +   S  
Sbjct: 2186 MLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSID 2245

Query: 303  D--VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYC 358
               +  + +Q++   QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +  
Sbjct: 2246 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2305

Query: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
              + G++      + +  +   ++    R L    S  LSDL     S+ ++ +   + N
Sbjct: 2306 DSLTGQLSDRCDWIDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMN 2361

Query: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDK 476
              L  AQ ++ E         V     E     DLS  ++    +A  S   EG  +  K
Sbjct: 2362 QQLETAQKMKQEIQQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFK 2416

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQ 533
            D             + +  E +V+  ++A         A   Q +Q+ +      D++ +
Sbjct: 2417 D-------------VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKE 2455

Query: 534  IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNL 592
             Q   + I +K      L   +K + K L   S   + ++   E+ L + + S    + L
Sbjct: 2456 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2515

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +T      W+    Q   +E ++K++L+K  ++   + ++W W+   +  LE+  
Sbjct: 2516 QLNTIKT-----NWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE-- 2568

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             ++   D    E  I KLK LQK +D    ++  +N  +         +   + D    +
Sbjct: 2569 -IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSL 2627

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNL 768
              + D V   L   +  L++   + + F E+S      L    E +D   +      SN 
Sbjct: 2628 IQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 2687

Query: 769  DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
               +LQ   K L  +KH++    L     QD+  +   +++GT   +   +V  I     
Sbjct: 2688 YLTMLQTQQKSLQALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHS 2741

Query: 829  LLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 882
             L ++V      LE KL  +   Q  +    S      DELD+   V    GR     QK
Sbjct: 2742 TLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 2797



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 166/889 (18%), Positives = 342/889 (38%), Gaps = 95/889 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES----ELA 71
            E++ KL    DR++ L          LK+ +   Q  +     L   L   E+     L+
Sbjct: 1601 EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS 1660

Query: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
            +PI  D  N   +QR+L E + LQ  I      V  +    EVLL D       A+ D I
Sbjct: 1661 EPIAVDPKN---LQRQLEETKALQGQISSQQVAVEKLKKTAEVLL-DARGSLLPAKND-I 1715

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 191
            Q+   ++  R+ ++     ER  K++ T        D      DW+ + E +        
Sbjct: 1716 QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVP 1775

Query: 192  VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRW 251
            +  T  ++ + K    ++ +    + +  +N++ ++        +A SL+  + + + R+
Sbjct: 1776 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARF 1835

Query: 252  DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-IKQ 310
                 +    L +++    + E FE   + +  +L       T  +  +E DV  K + +
Sbjct: 1836 SEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE------TKTQALTEVDVPGKDVTE 1889

Query: 311  LKAFQQEIS---LNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRR---------- 356
            L  + QE +   L H K +E + +  +++     P D A++ E+ + L +          
Sbjct: 1890 LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK 1949

Query: 357  -------YCQEVFGRVERYHKKL--------IRLPLPDDEHDLSDRELELEDSAALSDLH 401
                    CQE     +   K L         ++P+        D    LED+  L +  
Sbjct: 1950 EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE-K 2008

Query: 402  WHDRSADSLLSP--QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
            W      SL +P  Q  +N  +SL   + +  +     A+V S     + +   +   E 
Sbjct: 2009 W------SLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2062

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
              ++ L S  ++  D    Y    + L D           K+ E            L ++
Sbjct: 2063 WANKGLTSIKKDMTDISHGYEDLGLLLKD-----------KIAE------------LNTK 2099

Query: 520  IRQLGKALDDSRFQIQQTENIIRSKT-------PTGPE-LDTSYKGYMKLLGECSSSIDS 571
            + +L KA ++S   +Q  + + ++ T       PT  E + T  +       E   +++ 
Sbjct: 2100 LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNK 2159

Query: 572  VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFN 631
            V+ L+ KL E  E  P        +     +  +W+ L    + ++ +++++     QF 
Sbjct: 2160 VQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ 2219

Query: 632  SDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCS 691
            +    +  WL   E+EL       LS D   +  Q ++++ L +    RK     +    
Sbjct: 2220 TVEAQLKQWL--VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAG 2277

Query: 692  PEFTQADSKESR---DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                    ++      ++++L+ +  +WD +   L +    +  A+++   +  +   L 
Sbjct: 2278 QGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS 2337

Query: 749  LMLENIDRRKNEIVPIDSNLDA--EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV 806
              L ++D + +  + + ++ DA  + L+   K   +I+ E  + ++  A  +D+S   LV
Sbjct: 2338 DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSA--LV 2395

Query: 807  NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 855
              E     E   ++  I    K + ++   H++ L+     S   Q +S
Sbjct: 2396 KEEYLKA-ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2443



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 158/857 (18%), Positives = 337/857 (39%), Gaps = 75/857 (8%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES--ELAKPI 74
            I+  L  ++ +   LLD   AR ++++ T+  +++    +      L   E   E   P+
Sbjct: 2839 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV 2898

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
                  +E I ++LN  +  Q++  +   G    +N     L    A +T  +   ++  
Sbjct: 2899 ---GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHD 2953

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 194
              +++ RW+ +     +R  +++E      +F D       W+  +E   A        +
Sbjct: 2954 LDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEF 3013

Query: 195  TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 254
             V K ++++ +  QR + +  + +E+I ++  ++A          + + +   + RW+ L
Sbjct: 3014 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3073

Query: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLK 312
              +  +  R+L+      ++F    + +  WLT ++ +L N E        ++ +I Q K
Sbjct: 3074 LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3133

Query: 313  AFQQEISLNHNK-IEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV----FGRVER 367
            A + +I +NHNK + Q ++ G+ L   S   D  +++ +LD  + +  E+      R E 
Sbjct: 3134 ALEDDI-INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3192

Query: 368  YHKKLIRLPL-PDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
              + L    +  +DE +L +   E+ D   LS L   D S + L   Q    +       
Sbjct: 3193 LQQALCNAKIFGEDEVELMNWLNEVHDK--LSKLSVQDYSTEGLWKQQSELRV------- 3243

Query: 427  LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
                          D +  + + D  L   LE                     L+   G 
Sbjct: 3244 -----------LQEDILLRKQNVDQALLNGLE--------------------LLKQTTGD 3272

Query: 487  SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-----QQTENII 541
              ++I +  EA +K     I   S D +    Q  QL + L  +  ++     +    ++
Sbjct: 3273 EVLIIQDKLEA-IKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELL 3331

Query: 542  RSKTPT--GPELDTSYKGYMKLLGECSSS---IDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              +T    G E   +     +L  E  ++   +DS+  +   L E    L  +      E
Sbjct: 3332 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE----LVPWRAREGLE 3387

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 656
               A   +R+ L+      K   +   + + QQF+   ++  +W+ +TE++L  L  + L
Sbjct: 3388 KMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3447

Query: 657  STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRW 716
              D  + +LQ++K   ++  + H+  I   +       T    +E + ++ +L ++   +
Sbjct: 3448 EQDQTSAQLQVQKTFTME-ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNY 3506

Query: 717  DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH 776
            D +C +  E    L+ A      F E    L   L       +++ P  + L+ E L+  
Sbjct: 3507 DTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL-PAPA-LEYETLRQQ 3564

Query: 777  HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSR 836
             ++  Q++  + E +  +  +     QLL  + G +    +EK          + ++V +
Sbjct: 3565 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG-EGFSIQEKYVAADTLYSQIKEDVKK 3623

Query: 837  HIKELEKLLDVSSSQQD 853
                L++ +  S+   D
Sbjct: 3624 RAVALDEAISQSTQFHD 3640



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 152/877 (17%), Positives = 347/877 (39%), Gaps = 83/877 (9%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE++A  +  +   +I  +L  ++ RW+ LL+    R ++L+   V  QQ  + +  L  
Sbjct: 3044 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3103

Query: 62   WLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            WL  IE  L   +PI      + +++ ++ + + L+ DI  H+  +   +++ + L    
Sbjct: 3104 WLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL---- 3156

Query: 120  DACATDAECDSIQQATRNLDRRWR-NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
                +  E   + Q+  +  + W   I   S  R   +++     + F +D     +WL 
Sbjct: 3157 -KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3215

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY--------RRLAR 230
                  +  S    +   + E L K ++  R + E +    L+ KQ           L +
Sbjct: 3216 EVHDKLSKLS----VQDYSTEGLWKQQSELRVLQEDI----LLRKQNVDQALLNGLELLK 3267

Query: 231  ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD 290
            +   D    ++  +     R+ ++ K  T + + L+  +       +  + +  WL +++
Sbjct: 3268 QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE 3327

Query: 291  LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
            ++L + E       +A   Q++  + +    +NK          L++    + +A++E  
Sbjct: 3328 VELLSYETQVLKGEEASQAQMRPKELKKEAKNNK---------ALLDSLNEVSSALLELV 3378

Query: 351  LDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADS 409
                R   +++     ERY  +L+         D   +++E  D+A L    + D++AD+
Sbjct: 3379 PWRAREGLEKMVAEDNERY--RLV--------SDTITQKVEEIDAAILRSQQF-DQAADA 3427

Query: 410  LLSPQPSSNLSLSLAQPLRSERSGRDTPASVD-SIPLEWDHDYDLSRDLESAMSRALPSE 468
             LS    +   L     +R E+        V  +  +E     D+  DL  +  + + + 
Sbjct: 3428 ELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC 3487

Query: 469  DEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD 528
             EE +      L   +   D +   + E Y++L               +S + Q  +  +
Sbjct: 3488 SEEEKQSMKKKLDKVLKNYDTICQINSERYLQL------------ERAQSLVNQFWETYE 3535

Query: 529  DSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +    + +T++II        E +T       ++   +L+ E    ID + +   +L E 
Sbjct: 3536 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3595

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                 GF    S + +       +  ++     + + + + + +  QF+  ++ I   L 
Sbjct: 3596 SPG-EGF----SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LE 3647

Query: 643  DTEEELEQL-QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
              E  +E+L Q   +S +++ I+ QI + K +   ++  + +  ++     E        
Sbjct: 3648 SLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 3707

Query: 702  SRDL-----QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
             +D+     QD+L QM   W+ + +L+EE    L D +   + F      L++ +++   
Sbjct: 3708 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 3767

Query: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
               ++   D  +D  +++   +    I+ E+   Q  +  + ++  +L+      D    
Sbjct: 3768 FIRDLE--DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 3825

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 853
            K+ +  + +    L K     I +LE+ +  +   QD
Sbjct: 3826 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 3862



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 73/379 (19%), Positives = 169/379 (44%), Gaps = 17/379 (4%)

Query: 3    ERLAKASHESK---ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 59
            E +A++    K   A  ++ KL ++   W+++  L+  R  KL + +   ++   +  SL
Sbjct: 3699 EMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 3758

Query: 60   RTWLAHIES---ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL 116
               +   +    +L  P +  S         + +QQE    I +   G+   L++   L 
Sbjct: 3759 IVTIKDTQDFIRDLEDPGIDPSV--------VKQQQEAAETIREEIDGLQEELDIVINLG 3810

Query: 117  HDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 176
             +  A   + +   ++++   L+  W ++     +R  K+EE  +   ++ D      DW
Sbjct: 3811 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 3870

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            +  +    A  S  G      K+++++ + F+ + ++   ++E +N Q   L ++   +S
Sbjct: 3871 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEES 3930

Query: 237  -ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
               +++  + E    WD+L++R+ +   +L+  +    +F+ A D +L WLT  +  L+ 
Sbjct: 3931 DKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE 3990

Query: 296  IEHFSECDVQAKIKQLK--AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             +         +I+  K    Q ++  + + +E +   G  LIE S   +A+ ++ +L+ 
Sbjct: 3991 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEV 4050

Query: 354  LRRYCQEVFGRVERYHKKL 372
            L +  Q V  + E+  ++L
Sbjct: 4051 LNQRWQNVLEKTEQRKQQL 4069



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 168/922 (18%), Positives = 348/922 (37%), Gaps = 106/922 (11%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE L   +  S+ + ++ +L  +   W      +  R  KLKE+L    +  + + +L  
Sbjct: 2498 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 2557

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD- 120
            W+   ++ L +  +    +  E +  + + + LQ+++++H   V  + N    LL  C+ 
Sbjct: 2558 WIDKCQNNLEE--IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2615

Query: 121  --ACATDAECDSIQQATRNLDR-RWRNICAMSMERRLK-IEETWRLWQKFLDDYSRFEDW 176
                 TD     IQ+     ++   +  C  +M ++ K  +E  +  ++ L       D 
Sbjct: 2616 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD- 2674

Query: 177  LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQV--------------------HECLT 216
            +  S  + A+   S    T+ + + K  +A + QV                     + L 
Sbjct: 2675 IHDSLGSQAY---SNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 2731

Query: 217  QLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE 276
            Q+E I +++  L+++   D  CS  +   +G   + N           ++    Q  EF+
Sbjct: 2732 QVETIAQEHSTLSQQ--VDEKCSFLETKLQGIGHFQN----------TIREMFSQFAEFD 2779

Query: 277  TARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLI 336
               DS    +  +      ++   E  ++A +K+L+A        +   + ++A      
Sbjct: 2780 DELDS----MAPVGRDAETLQKQKE-TIKAFLKKLEALMASNDNANKTCKMMLA-----T 2829

Query: 337  EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAA 396
            E++ P D   I+ +L+ L + C ++  R +   +++       +E     +E     S  
Sbjct: 2830 EETSP-DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF----SIL 2884

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
            L     H+ S   +     + N  L++ +  + E      P       + W     L + 
Sbjct: 2885 LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI---EPLQGKQQDVNW-----LGQG 2936

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
            L  + +++  ++  E              L DV       A  K     +   +      
Sbjct: 2937 LIQSAAKSTSTQGLEHD------------LDDV------NARWKTLNKKVAQRAAQLQEA 2978

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDT------SYKGYMKLLGECSSSID 570
                 +   AL+     +  TE ++ ++ P   E           K   +LL +  S+++
Sbjct: 2979 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3038

Query: 571  SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 630
             +KR   K+    E       L     Q + +  RWE L  +A ++  +++      QQF
Sbjct: 3039 VIKREGEKIATTAEPADKVKIL----KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3094

Query: 631  NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ-KAVDHRKAIILSINL 689
            +  L  +  WL   E+ L   +   + T    +E QI + K L+   ++H K +  ++++
Sbjct: 3095 HETLEPLNEWLTTIEKRLVNCE--PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI 3152

Query: 690  CSPEFTQADSKESRDL-QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
                     S+E +D+ Q +L      +  +         LLQ AL   + F E    L+
Sbjct: 3153 -GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3211

Query: 749  LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 808
              L  +  + +++   D     E L     +L  ++ ++L  +  V        +LL   
Sbjct: 3212 NWLNEVHDKLSKLSVQD--YSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3269

Query: 809  EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADELD 864
             G + L  ++K+  I  R K + K  +   K LE+ L ++    S+ ++L +W    E++
Sbjct: 3270 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3329

Query: 865  -TSGSVSPTSGRSTPNRQKTPR 885
              S       G      Q  P+
Sbjct: 3330 LLSYETQVLKGEEASQAQMRPK 3351



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 162/881 (18%), Positives = 342/881 (38%), Gaps = 71/881 (8%)

Query: 6    AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 65
            A+ S     ++I+  L  +  R++ L   +  R +KL+ TL     +   +  +  W+ +
Sbjct: 1704 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN 1763

Query: 66   IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            +ES L K       NS  +Q  +++   L++DI    + + ++    +  +   D     
Sbjct: 1764 VESSL-KEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD----P 1818

Query: 126  AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            +   S+Q   ++L  R+        E   K+EE     + F +   + + +L++  +   
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 1878

Query: 186  FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                 G   T   + +++  +   +  E    LE+++   + ++          + +  +
Sbjct: 1879 EVDVPGKDVTELSQYMQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTN 1935

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDV 304
              ++++  ++  +      +     Q + F+    S+  W+ E   ++  ++  F   D+
Sbjct: 1936 NLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDL 1995

Query: 305  QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE----KSEPLDAAIIEEELDELRRYCQE 360
               ++  K  Q++ SL   +I+++   G  L       + P  A    +    +      
Sbjct: 1996 GKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGT 2055

Query: 361  VFGRVERYHKK---LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
                 E +  K    I+  + D  H   D  L L+D  A      + + +    + + SS
Sbjct: 2056 ATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA----ELNTKLSKLQKAQEESS 2111

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
             +   L +  ++    + TPA  D+  ++   + + S + E      L     + Q+ KD
Sbjct: 2112 AMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE------LKQNVNKVQELKD 2165

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ---- 533
                      D   PE+P     LTE   K    +   ++ Q +    + + ++FQ    
Sbjct: 2166 KLTELLEENPDT--PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2223

Query: 534  -----IQQTENIIRSKTPTGPE---LDTSYKGYMKLLGECSSSIDSVKRLEH------KL 579
                 + + E ++    P   +   L+T  +    LL E ++     ++L          
Sbjct: 2224 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2283

Query: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
              E+ SL G V     + Q A V  +W+ L  Q   +   + Q + K  Q+ S L S+  
Sbjct: 2284 PGEDPSLRGIV-----KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSD 2338

Query: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV-DHRKAIILSINLCSPEFTQAD 698
             L D + +L     L +ST    +  Q++  +++++ +   +K I ++  LC  E   A 
Sbjct: 2339 KLSDLDNKLS--SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC--EDLSAL 2394

Query: 699  SKE---SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
             KE     +L  +L  +   +  V    E     LQ A      F +MS      L+   
Sbjct: 2395 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2454

Query: 756  RRKNEIVPIDSNLDA--EILQDH---HKQLMQIKH----ELLESQ---LRVASLQDMSCQ 803
              +N+  PI + LD    +++DH    K L    H     + E +   L+    +  + Q
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2514

Query: 804  LLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 844
            L +N   T+     ++V    N+LK  L++  ++ +++E L
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2555



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 162/891 (18%), Positives = 354/891 (39%), Gaps = 104/891 (11%)

Query: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
            K  ++ +RWQ++   I  R++ L+    +++        L  W+  +E+   K       
Sbjct: 937  KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE 996

Query: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
            NS+ +  +LN+Q+ L  +IE       S ++ C+       A   D E  ++      +D
Sbjct: 997  NSKTLATQLNQQKMLVSEIEMKQ----SKMDECQKYAEQYSATVKDYELQTMTYRAM-VD 1051

Query: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
             + ++     ++RR        + Q+F+D  +R+   +    +   F   S  +  + +E
Sbjct: 1052 SQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEE 1105

Query: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVT 259
            E    E  +  V +     + ++   + L    +       KQ +   ++     +++++
Sbjct: 1106 EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI--SSEEISTKKEQLS 1163

Query: 260  SILRRLKHFIG---------QREEFE----TARDSILVWLTEMDLQLTNIEHFSECDVQA 306
              L+ ++ F+          +R E E    T ++S  +  +E   QL   +   +  V+ 
Sbjct: 1164 EALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEE 1223

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC--QEVFGR 364
            KI   +  QQE       I  ++ Q E  +   +  +A +I +   EL++Y   QE   +
Sbjct: 1224 KIVAER--QQEYKEKLQGICDLLTQTENRLIGHQ--EAFMIGDGTVELKKYQSKQEELQK 1279

Query: 365  VERYHKKLIRLPLPDDEHDLSDRELEL-EDSAALSDLHWHDRSAD----SLLSPQPSSNL 419
              +   + +   + + E+ L +   +L ++  AL +   ++        +L + Q    L
Sbjct: 1280 DMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKEL 1339

Query: 420  SLSLAQPLRSE-------RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 472
               +   ++ E       +   ++   ++++ L+W  + D  +D E A ++     ++ G
Sbjct: 1340 DKVVTTAIKEETEKVAAVKQLEESKTKIENL-LDWLSNVD--KDSERAGTKHKQVIEQNG 1396

Query: 473  QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRF 532
               ++   + A+G       E  E    L E  +    G      +Q  Q  KA      
Sbjct: 1397 THFQEGDGKSAIG-------EEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA------ 1443

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
               Q E II                   ++   S+ +   K+ ++   EE+E L   +  
Sbjct: 1444 ---QHEKIISQHQAV-------------IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1487

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
                 +TA      ++    +L +EL         ++F++D      WL  +E+ELE L+
Sbjct: 1488 LKVHYETALAESEKKMKLTHSLQEEL---------EKFDADYTEFEHWLQQSEQELENLE 1538

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA-------------DS 699
                + DI  +  ++K+ K   + V   K  +  I +      +A              S
Sbjct: 1539 --AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTS 1596

Query: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
               R++Q +L     R+  + S        L+D + + Q + + S GLL  L+  +   +
Sbjct: 1597 ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS 1656

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 819
            + +     +D + LQ   ++   ++ ++   Q+ V  L+  + ++L++A G+  L AK  
Sbjct: 1657 KHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK-KTAEVLLDARGS-LLPAKND 1714

Query: 820  VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE-LDTSGSV 869
            +    + +    +++S+ + E  + L ++ + + LS     DE LD  G+V
Sbjct: 1715 IQKTLDDIVGRYEDLSKSVNERNEKLQITLT-RSLSVQDGLDEMLDWMGNV 1764



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 188/971 (19%), Positives = 363/971 (37%), Gaps = 161/971 (16%)

Query: 43   KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 102
            KE +   ++L K +S++   L   E     P      +SEEI  K  +  E         
Sbjct: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE--------- 1164

Query: 103  TGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR--------L 154
                  L   ++ L       TD E + +++  + L   +  + + S+++         +
Sbjct: 1165 -----ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219

Query: 155  KIEE--TWRLWQKFLDDYSRFEDWLKSSERTA-----AFPSSSGVIYTVAKEELKKFEAF 207
            K+EE       Q++ +      D L  +E        AF    G +      ELKK+++ 
Sbjct: 1220 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV------ELKKYQSK 1273

Query: 208  QRQVH-------ECLTQL------------ELINKQYRRLARENRTDSACSLKQMVHEGN 248
            Q ++        + L ++            E ++++ + L  +   ++    +Q+  +  
Sbjct: 1274 QEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAE 1333

Query: 249  QRWDNLQKRVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLT----------- 294
            Q    L K VT+ ++     +    Q EE +T  +++L WL+ +D               
Sbjct: 1334 QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1393

Query: 295  -NIEHFSECDVQAKIK----------------QLKAFQQEISLNHNKI----EQIIAQ-- 331
             N  HF E D ++ I                 Q+   Q+ ++  + K+    E+II+Q  
Sbjct: 1394 QNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQ 1453

Query: 332  --------GEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD 379
                     + L+EK      P +   +++ + EL+ + +      E+  K         
Sbjct: 1454 AVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT------- 1506

Query: 380  DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 439
              H L + ELE  D+      HW  +S   L + +  ++    L   L+ ++S      S
Sbjct: 1507 --HSLQE-ELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS-----FS 1558

Query: 440  VDSIPLEWDHDYDL---SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
             D I  + D  Y     +R LE+A S    S+ + G+ D     R      D        
Sbjct: 1559 EDVISHKGDLRYITISGNRVLEAAKSC---SKRDGGKVDTSATHREVQRKLDHATDRFRS 1615

Query: 497  AYVK--LTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 554
             Y K  +  N +K+    +   E     L   L     +   ++++          L   
Sbjct: 1616 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQAC--EATASKHLSEPIAVDPKNLQRQ 1673

Query: 555  YKGYMKLLGECSSSIDSVKRL----EHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 610
             +    L G+ SS   +V++L    E  L      LP   ++  T     G   R+E L 
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG---RYEDLS 1730

Query: 611  AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL-STDIQTIELQIKK 669
                 +  +++  L +       L+ +  W+G+ E  L++  ++ L ST +Q I   I K
Sbjct: 1731 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISK 1787

Query: 670  LKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 728
               L++ +  R++ I ++N    +F +  D   +  LQ ++  ++ R+       +E   
Sbjct: 1788 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 1847

Query: 729  LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI-VP-IDSNLDAEILQDHHKQLMQIKH- 785
             +++   + + F  +S  L   LE   +   E+ VP  D    ++ +Q+   + ++ K  
Sbjct: 1848 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 1907

Query: 786  -ELLESQLRVASLQDMSCQLLVNAEGTDCL------------EAKEKVHVIGNRL---KL 829
             E+L S L+  S   +     +  E T+ L            E KE V     +L   ++
Sbjct: 1908 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 1967

Query: 830  LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCS 889
            L+K +   IKE  K + +   Q    +      L+ +  +       TP  QK      S
Sbjct: 1968 LVKSLKSWIKETTKKVPI--VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2025

Query: 890  LSQPGPSVSSP 900
            L     +V++P
Sbjct: 2026 LCNLISAVTTP 2036



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 149/753 (19%), Positives = 298/753 (39%), Gaps = 117/753 (15%)

Query: 171  SRFEDWLKSSERTAAFPSSS--------GVIYTVAKEELKKFEAFQRQVHECLTQLELIN 222
            SRFED+L+ S+ +  F  S          V     +E LK  E  + +  E +  L +  
Sbjct: 688  SRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE--REEQEESVYNLYISE 745

Query: 223  KQYRRLARENRTDSACSLKQMVHEGNQRWDNL-----QKRVTSILRRLKHFIG----QRE 273
             +  RL  EN  D      +   E +   +++     Q+++   L RLK  +G    + E
Sbjct: 746  VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 805

Query: 274  EF---ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 330
            EF     A  S+    +E+++ L N+           I +LK     +  N    E ++ 
Sbjct: 806  EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMS-STYIDKLKTVNLVLK-NTQAAEALVK 863

Query: 331  QGEQLIEKSEPL--DAAIIEEELDELRRYCQEVFGRVERYH---KKLIRLPLPDDEHDLS 385
              E  + + E +  D   IE  +  L+++  EV  + + +H    +L +     DE   +
Sbjct: 864  LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKT 923

Query: 386  DRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS-ERSGRDTPASVDSI- 443
             +E +L       D  WH   AD L+  +   N+ + +   LR  E  G+      D+  
Sbjct: 924  YKERDL-------DFDWHKEKADQLV--ERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYH 974

Query: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
            PL+     D  + +E+   +   ++ E  +       +  + +S++ + +S     +   
Sbjct: 975  PLD-----DWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1029

Query: 504  NAIKNTSGDHSALESQIRQLGKALDDS---RFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
                 T  D+       R +  +   S   R ++Q + ++I  +     +L T Y   + 
Sbjct: 1030 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF---MDLRTRYTALVT 1086

Query: 561  LLGE-CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRW------ELLQAQA 613
            L+ +    + DS+KRLE    EEE+SL      H    + A  + +W       L  A+ 
Sbjct: 1087 LMTQYIKFAGDSLKRLE----EEEKSLEEEKKEH---VEKAKELQKWVSNISKTLKDAEK 1139

Query: 614  LSKELRMKQNLQ------KWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIE--- 664
              K    KQ +       K +Q +  L +I  +L    +++   +R EL   ++T++   
Sbjct: 1140 AGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESY 1199

Query: 665  --LQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCS 721
              L  + LK+LQ++                  T  D K E + + +R  +   +   +C 
Sbjct: 1200 NLLFSESLKQLQESQ-----------------TSGDVKVEEKIVAERQQEYKEKLQGICD 1242

Query: 722  LLEEWRG---------LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
            LL +            ++ D  ++ + +      L   ++   +   E+V    N     
Sbjct: 1243 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTEN----F 1298

Query: 773  LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            L+++ ++L Q    L+E +L  A ++   C+ L        L+A++    +   +   +K
Sbjct: 1299 LKENGEKLSQEDKALIEQKLNEAKIK---CEQL-------NLKAEQSKKELDKVVTTAIK 1348

Query: 833  EVSRHIKELEKLLDVSSSQQDLSSWSSADELDT 865
            E +  +  +++L +  +  ++L  W S  + D+
Sbjct: 1349 EETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1381



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 119/677 (17%), Positives = 261/677 (38%), Gaps = 100/677 (14%)

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            D + D  ++    L  RW+N+      R   +E   +  + + D Y   +DW++  E T 
Sbjct: 928  DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987

Query: 185  A-----FPSSSGVIYTVAKEE---LKKFEAFQRQVHEC----------LTQLELINKQYR 226
                   P +S  + T   ++   + + E  Q ++ EC          +   EL    YR
Sbjct: 988  RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR 1047

Query: 227  RLARENRTDSACSLKQMVHEGN---QRWDNLQKRVTSILRRLKHFIGQREEFETARDSIL 283
             +  +++  S    ++M    +   Q + +L+ R T+++  +  +I      + A DS+ 
Sbjct: 1048 AMV-DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI------KFAGDSL- 1099

Query: 284  VWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 343
                    +L   E   E + +  +++ K  Q+ +S     ++     G+    K +   
Sbjct: 1100 -------KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQK--- 1149

Query: 344  AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 403
              I  EE+   +    E    ++ +  K       ++ ++L  +   L++S  L      
Sbjct: 1150 --ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNL----LF 1203

Query: 404  DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWD-----HDYDLSRDLE 458
              S   L   Q S ++ +        ++  ++    +  +  + +     H         
Sbjct: 1204 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1263

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
            +   +   S+ EE Q D       A  L++V+  ++ E ++K  EN  K +  D + +E 
Sbjct: 1264 TVELKKYQSKQEELQKDMQ---GSAQALAEVV--KNTENFLK--ENGEKLSQEDKALIEQ 1316

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++ +     +    + +Q++           ELD   K     + E +  + +VK+LE  
Sbjct: 1317 KLNEAKIKCEQLNLKAEQSKK----------ELD---KVVTTAIKEETEKVAAVKQLEES 1363

Query: 579  LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL--NS 636
             K + E+L  +++    +++ AG   +  + Q     +E   K  + +  + N +L    
Sbjct: 1364 -KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1422

Query: 637  IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKAIILSIN----LCS 691
            +   +G T+E L Q               Q +K+K + +K +   +A+I++      L  
Sbjct: 1423 VDGQVGTTQENLNQ---------------QYQKVKAQHEKIISQHQAVIIATQSAQVLLE 1467

Query: 692  PEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL---LQDALMQCQG-FHEMSHGL 747
             +      +E   LQ  + ++   ++   +  E+   L   LQ+ L +    + E  H L
Sbjct: 1468 KQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWL 1527

Query: 748  LLM---LENIDRRKNEI 761
                  LEN++   ++I
Sbjct: 1528 QQSEQELENLEAGADDI 1544



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 61/327 (18%), Positives = 134/327 (40%), Gaps = 36/327 (11%)

Query: 499 VKLTENAIKNTSGDHSALESQI-----RQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 553
           +++ +  +K++  D +  E +I     + L   +D+ + Q+ +TE    S  P+      
Sbjct: 256 MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE--WGSDLPSVESHLE 313

Query: 554 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 613
           ++K   + + E  SS+      E K+ E + + P        +   A  + R E   A+ 
Sbjct: 314 NHKNVHRAIEEFESSLK-----EAKISEIQMTAP-------LKLTYAEKLHRLESQYAKL 361

Query: 614 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-- 671
           L+     +++L     F S   +   WL + EEE       E++ D       I + K  
Sbjct: 362 LNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE-------EVAYDWSERNTNIARKKDY 414

Query: 672 --ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 729
             EL + +D ++  I S+   + +    +      ++   + M  +W  +  L +     
Sbjct: 415 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 474

Query: 730 LQDALMQCQGFHEMSHG--LLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 787
           +++     + F++       L  L++  +RK      D +     L+D  ++ M+ K EL
Sbjct: 475 IKENTAYFEFFNDAKEATDYLRNLKDAIQRK---YSCDRSSSIHKLEDLVQESMEEKEEL 531

Query: 788 LESQLRVASLQDMSCQLL-VNAEGTDC 813
           L+ +  +A+L   +  ++ +    +DC
Sbjct: 532 LQYKSTIANLMGKAKTIIQLKPRNSDC 558


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  120 bits (302), Expect = 5e-27
 Identities = 175/943 (18%), Positives = 380/943 (40%), Gaps = 107/943 (11%)

Query: 8    ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE 67
            A  +  A EI+ KL ++   W+ +      R  K  + L   ++   +M++L T +   +
Sbjct: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4568

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
                  IV+D  +       + +Q E    I++ + G+   L    +L  D      + E
Sbjct: 4569 D-----IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETE 4623

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
               ++++   ++  W N+     ER  K+E+  +   ++ D      DWL ++       
Sbjct: 4624 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLKQMVH 245
               G      K++L + + F+ +V++   ++E +N Q   + ++  + TD    +++ + 
Sbjct: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLT 4742

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD-- 303
            E    W+NL +++     +L+  +    +F+ A + ++ WLT  + +L + +     D  
Sbjct: 4743 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPK 4801

Query: 304  -VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
             ++ ++ +    + ++  +   +E +   G +L+E S   DA+ +   L+ + +  + V 
Sbjct: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861

Query: 363  GRVERYHKKL---------IRLPLPDDEHDLSDRELELEDS--------AALSDLHWHDR 405
             + E   ++L             + D   +L+  E +L  S         A   L  H  
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921

Query: 406  SADSLLSPQPSSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAM 461
                L + + + N  L   + +   R    SG  T  SV  +  +W        + +S +
Sbjct: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4981

Query: 462  SRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAI---KNTSGDHSALES 518
              AL    E     ++F     +    + I   P   +    + I   K  + + +A   
Sbjct: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041

Query: 519  QIRQLGKALDDSRFQIQQT----------------ENIIRSKTPTGPELDTS-------Y 555
            QI +L +  +  +F  Q+                 E +++     G  LD +       +
Sbjct: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 5101

Query: 556  KGYMKLLG-------------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 602
            + + KL+              E S+  D +K    K KE +++L G   ++ T  +T   
Sbjct: 5102 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRA 5161

Query: 603  I---------------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
            +                     D+W+ +  +++ ++ ++++ L    QF   L ++  WL
Sbjct: 5162 LKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWL 5221

Query: 642  GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
               E +L + Q   +  D+  +   +   K  QK +  R   +  +     E  +    +
Sbjct: 5222 YKVEPQLAEDQ--PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDD 5279

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKN 759
            +  ++ +L +++ RWD VC L    +  L+ AL Q + F +  H LL  L   ++  R  
Sbjct: 5280 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 5339

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KE 818
              +P D+    + L D HK+ M+   ++ E ++ V S   M  ++++     DC+   K 
Sbjct: 5340 GALPDDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKH 5394

Query: 819  KVHVIGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 857
             + +I  R + +L    +H + LE  L   V++++  ++L +W
Sbjct: 5395 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 5437



 Score =  113 bits (283), Expect = 8e-25
 Identities = 169/806 (20%), Positives = 335/806 (41%), Gaps = 86/806 (10%)

Query: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
            L KA+ E+    I   L ++   W++L + IA R  KL+  L+A+ Q    +  L +WL 
Sbjct: 4725 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4784

Query: 65   HIES--ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
            H E   +  +PI   S + + I+ +L +   L+ D+  H   V +V      LL   ++ 
Sbjct: 4785 HTEELLDAQRPI---SGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELL---ESS 4838

Query: 123  ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            A D +  S++     +++ W ++   + ER  +++ T +  Q F   +S  ED+L    R
Sbjct: 4839 AGD-DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGF---HSEIEDFLLELTR 4894

Query: 183  TAAFPSSS---GVIYTVAKEEL-KKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
              +  S+S   G +   A+E+L    E + +   +  T  +L++K    L   + + S  
Sbjct: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4954

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT--EMDLQLTNI 296
              +Q V    Q+W  +  ++     +L+  +    EF+ +    + WLT  E  L + + 
Sbjct: 4955 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASP 5014

Query: 297  EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                   V ++I++ K F  E++ + ++I ++   G QL   S+  D  +I+  L  ++ 
Sbjct: 5015 PSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQS 5074

Query: 357  YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 416
              ++V  R     + L          D + +  +    A    + W + +   L S    
Sbjct: 5075 RWEKVVQRSIERGRSL----------DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124

Query: 417  SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-RDLESAMSRALPSEDEEGQDD 475
            SN    +   L   +  + T      +       YD + R   +   + L  ED +  D+
Sbjct: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPV-------YDTTIRTGRALKEKTLLPEDSQKLDN 5177

Query: 476  KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535
               +L       D +  +S E   KL E  +            Q     +AL D  +++ 
Sbjct: 5178 ---FLGEVRDKWDTVCGKSVERQHKLEEALL---------FSGQFMDALQALVDWLYKV- 5224

Query: 536  QTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 589
              E  +    P   +LD       ++K + K LG+ + ++  +KR   +L E       +
Sbjct: 5225 --EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282

Query: 590  VNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
            V     E  T     RW+ +   ++SK+ R++Q L++ + F   ++ +  WL + E+ L 
Sbjct: 5283 VKGQLQELST-----RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337

Query: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS--------INLCSPEFTQADSKE 701
               R  L  D + ++  I   KE  K V+ ++  + S        + +C P+        
Sbjct: 5338 --FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITT---- 5391

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE----NIDRR 757
               ++  ++ +  R++ V +  ++ +  L+ AL +     E+   LL  ++     + +R
Sbjct: 5392 ---IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQR 5448

Query: 758  KNEIVPIDSNLD-AEILQDHHKQLMQ 782
              E  PI  N+D  + L   H+  M+
Sbjct: 5449 DQE--PIPQNIDRVKALIAEHQTFME 5472



 Score =  100 bits (250), Expect = 5e-21
 Identities = 147/795 (18%), Positives = 313/795 (39%), Gaps = 62/795 (7%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQL----DKNMSSLRTW 62
            K  +  +   +E K  K  + +  + + +  R   L E +    Q+    DK    L T 
Sbjct: 4392 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLET- 4450

Query: 63   LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
            L ++ S L  P +  +   ++I+  +++ +    ++EK      ++    E L+      
Sbjct: 4451 LENLSSRLRMPPLIPA-EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509

Query: 123  ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
              D     IQ     +   W +I A + ER +K  +   L +KF  D +     +K ++ 
Sbjct: 4510 DKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD 4569

Query: 183  TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ 242
                  S G+  ++ K++++  E  + +      +LE I      L           +++
Sbjct: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE- 301
             + E N  W+NL K     L +L+  +    +++    ++  WL    ++L  +      
Sbjct: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689

Query: 302  -CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK-SEPLDAAIIEEELDELRRYCQ 359
               V+ ++ ++K F+ E+     ++E++  QGE +++K ++  D  II E L EL+   +
Sbjct: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749

Query: 360  EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
             +  ++     KL                       AL  L     + + L+S    +  
Sbjct: 4750 NLGEKIAHRQHKL---------------------EGALLALGQFQHALEELMSWLTHTEE 4788

Query: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
             L   +P+  +            I +E    + L  D+  A    + + ++ G +     
Sbjct: 4789 LLDAQRPISGDPK---------VIEVELAKHHVLKNDV-LAHQATVETVNKAGNE----L 4834

Query: 480  LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQ---LGKALDDSRFQIQQ 536
            L  + G     +    EA  +  E+ ++ T      L+S ++Q       ++D   ++ +
Sbjct: 4835 LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTR 4894

Query: 537  TENIIRSKTPTG-------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 589
             E+ + +  PTG        +LDT  + Y +L  +  +    + +    L   ++S  G 
Sbjct: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSG- 4953

Query: 590  VNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
                 TE   A +  +W ++ ++   ++ ++++ L    +F + L     WL   E+ L 
Sbjct: 4954 ---SKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLN 5010

Query: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDR 708
                  L   + T+  QI++ K     V+  +  I+ ++    +      K+   L ++ 
Sbjct: 5011 IASPPSLI--LNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNL 768
            L  +  RW++V     E    L DA  + + FHE    L+  LE+ +   +  + I ++ 
Sbjct: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 5128

Query: 769  DAEILQ-DHHKQLMQ 782
            D   LQ   HK+  +
Sbjct: 5129 DKIKLQLSKHKEFQK 5143



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 152/861 (17%), Positives = 350/861 (40%), Gaps = 69/861 (8%)

Query: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
            +  A  +     +E+ + ++N RW  L   +A R+ +L+E L+   +    +  L +WLA
Sbjct: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796

Query: 65   HIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
              E  +A  KP    S   + ++ ++ EQ+ LQR ++     V       ++L  +    
Sbjct: 3797 DTEELIANQKP---PSAEYKVVKAQIQEQKLLQRLLDDRKATV-------DMLQAEGGRI 3846

Query: 123  ATDAECDSIQQAT---RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            A  AE    ++ T    +L+ RW  + + +  R+ ++E+   L ++F +      D+L  
Sbjct: 3847 AQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSV 3906

Query: 180  SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +E+  A     G      ++++ + +A +  +    T +    K  + L+          
Sbjct: 3907 TEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGV 3966

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI--E 297
            L + +     R+  +Q R       L   +     F      +L WL E++ +L+++  +
Sbjct: 3967 LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVK 4026

Query: 298  HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 357
             F +  +  +     A  +EI      ++Q I  G+ L++++   +  +I+E+LD ++  
Sbjct: 4027 DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTR 4086

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
              ++     +  + L +            R+L  +  +   +L    R  +  L+   S 
Sbjct: 4087 YADITVTSSKALRTLEQA-----------RQLATKFQSTYEELTGWLREVEEELA--TSG 4133

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
              S +  Q  + ++  ++    V    L  D   ++SR    A+   +P    EG D   
Sbjct: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR----ALLELVPWRAREGLDK-- 4187

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQT 537
                        ++ ++ E Y KL  + I     +  A   + +Q  +A D     + +T
Sbjct: 4188 ------------LVSDANEQY-KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAET 4234

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE-----HKLKEEEESLPGFVNL 592
            +  + +  P   E D +     +L  + + SID ++  +        + E     G    
Sbjct: 4235 KRKLMALGPIRLEQDQT---TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 4291

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +T  +I ++E +      +  R+++      QF      +  W+ +T   + QL 
Sbjct: 4292 TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLP 4351

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
                + D + +  Q +++++L++++   K  I  +    P+  + + +E   ++++  + 
Sbjct: 4352 --SPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKA 4409

Query: 713  NGRWDRVCSLLEEWRGLLQDAL---MQCQGFHEMSHGLLLMLENIDRRKN--EIVPIDSN 767
               + ++   + +    L +A+    Q   FH+    +L  LEN+  R     ++P + +
Sbjct: 4410 ENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVD 4469

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
               E + D+    +    EL + Q    +L+    +L+  ++G D   A +++    +++
Sbjct: 4470 KIRECISDNKSATV----ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4525

Query: 828  KLLLKEVSRHIKELE-KLLDV 847
                +++    +E E K LDV
Sbjct: 4526 VFFWEDIKARAEEREIKFLDV 4546



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 172/929 (18%), Positives = 368/929 (39%), Gaps = 85/929 (9%)

Query: 15   SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 74
            S+++ +L  +N +W  L D + +R  ++ + +V   Q  + +  L   +  +   L+   
Sbjct: 3091 SQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
               S   E ++++L E  E++ D+E+    V     LC+ L             D +++ 
Sbjct: 3151 AI-STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL---SVLIGEQYLKDELKKR 3206

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGV 192
               +    + +  ++ +R  +++      Q+F   +     WL  K S++    P S+ +
Sbjct: 3207 LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKL 3266

Query: 193  IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL------ARENRTDSACSLKQMVHE 246
                 + +L++ E FQ+ +++     E+I  +   L        E RT     L+  + E
Sbjct: 3267 --ERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT-----LQNQLVE 3319

Query: 247  GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDVQ 305
                W+ L K+      RLK  + + ++++   + ++ W+ +   +++ +        ++
Sbjct: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLE 3379

Query: 306  AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAI------IEEELDELRRYCQ 359
            + + + KA   E+    + +E + +  + LI  SE  +  I      I + +D +    Q
Sbjct: 3380 SSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQ 3439

Query: 360  EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
               G +E   ++L        E   S + +E +   A   L   D      L  Q  SN 
Sbjct: 3440 AKTGSLEEMTQRL-------REFQESFKNIEKKVEGAKHQLEIFDA-----LGSQACSNK 3487

Query: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
            +L   + LR+++             LE   DY  +       ++ L  +  +G D     
Sbjct: 3488 NL---EKLRAQQEVLQA--------LEPQVDYLRN------FTQGLVEDAPDGSDASQLL 3530

Query: 480  LRGAVGLSDVM-IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD--DSRFQIQQ 536
             +  V   + + + +   +   + EN ++     H  +     QL    D  D    I +
Sbjct: 3531 HQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGR 3590

Query: 537  TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              + ++S+      L  +    +KL  E S +        H L+EE     G ++L   +
Sbjct: 3591 DTDSLQSQIED-VRLFLNKIHVLKLDIEASEA-----ECRHMLEEE-----GTLDLLGLK 3639

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE- 655
             +   +  +   L  +  +++ +++  L + + F   L      L D     E+ + L+ 
Sbjct: 3640 RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQW 3695

Query: 656  -LSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQADSKES--RDLQDRLSQ 711
             + T+++ I  Q+   K  QK  VD  +  +  +N       Q+  K+   + L+  + +
Sbjct: 3696 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3755

Query: 712  MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 771
            +N RW+ +   + +    LQ+AL+ C  F +    LL  L + +       P  +     
Sbjct: 3756 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3815

Query: 772  ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 831
              Q   ++L+Q    L + +  V  LQ    ++  +AE  D  +   ++  + +R   LL
Sbjct: 3816 KAQIQEQKLLQ--RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3873

Query: 832  KEVSRHIKELEKLLDVS----SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGK 887
             + +   K+LE +L ++     + + +S + S  E   + S  P   ++   +Q+  R K
Sbjct: 3874 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS-EPVGTQTAKIQQQIIRHK 3932

Query: 888  CSLSQPGPSVSSPHSRSTKGGSDSSLSEP 916
                      +  H     G S SSL+ P
Sbjct: 3933 ALEEDIENHATDVHQAVKIGQSLSSLTSP 3961



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 80/375 (21%), Positives = 167/375 (44%), Gaps = 12/375 (3%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G  L ++S    AS +  +L  +N  W+ +L     R ++L+ TL   Q     +     
Sbjct: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890

Query: 62   WLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
             L  +ES+L+  KP        E  + +L+   EL   ++        +L+   ++L   
Sbjct: 4891 ELTRMESQLSASKPT---GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4947

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            D   + ++ +   Q+   L+++W  + +   ER+ K+EE   L  +F +    F +WL  
Sbjct: 4948 DDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTL 5004

Query: 180  SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +E++    S   +I      ++++ + F  +V+    Q+  +++   +L   ++      
Sbjct: 5005 AEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL 5064

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEH 298
            +K ++     RW+ + +R     R L     + ++F  A   ++ WL + +  L + +E 
Sbjct: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124

Query: 299  FSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRR 356
             ++ D ++ ++ + K FQ+ +       +  I  G  L EK+  P D+  ++  L E+R 
Sbjct: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRD 5184

Query: 357  YCQEVFGR-VERYHK 370
                V G+ VER HK
Sbjct: 5185 KWDTVCGKSVERQHK 5199



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 161/865 (18%), Positives = 338/865 (39%), Gaps = 90/865 (10%)

Query: 1    MGERLAKASHESKA--SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSS 58
            + ++  K +   KA   ++E  LG+V D ++ L        K L +   A ++ +     
Sbjct: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKL--------KGLNDATTAAEEAEALQWV 3696

Query: 59   LRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
            + T +  I  +LA   ++     + +Q KL +   L + + + S G             D
Sbjct: 3697 VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAG------------KD 3743

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
            CD    + + + I       + RW  +     +R  +++E      KF D       WL 
Sbjct: 3744 CDVQGLEHDMEEI-------NARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   A        Y V K ++++ +  QR + +    ++++  +  R+A+        
Sbjct: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3856

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
             +   +     RW  L  +  +  ++L+  +   ++F    + I  +L+  + +L N E 
Sbjct: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3916

Query: 299  F--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                   +Q +I + KA +++I  +   + Q +  G+ L   + P +  ++ E++D L+ 
Sbjct: 3917 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3976

Query: 357  YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 416
               E+  R  R    L        +  LS+  L  ED   +  L+W     D L     S
Sbjct: 3977 RYSEIQDRCCRKAALL--------DQALSNARLFGEDEVEV--LNWLAEVEDKL-----S 4021

Query: 417  SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 476
            S       Q +   +         D + L  +   +  ++++ A+        + GQ   
Sbjct: 4022 SVFVKDFKQDVLHRQ-------HADHLALN-EEIVNRKKNVDQAI--------KNGQ--- 4062

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-- 534
               L+   G   ++I E  +  +K     I  TS        Q RQL      +  ++  
Sbjct: 4063 -ALLKQTTGEEVLLIQEKLDG-IKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTG 4120

Query: 535  ---QQTENIIRS--KTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 586
               +  E +  S  ++PTG   P+     K   K + E    +D+V  +   L E    L
Sbjct: 4121 WLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE----L 4176

Query: 587  PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 646
              +      +   +   ++++L+      +   +   +Q+ QQ+    ++  AW+ +T+ 
Sbjct: 4177 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKR 4236

Query: 647  ELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQ 706
            +L  L  + L  D  T +LQ++K   +   + H+ ++    +  S  F     ++   LQ
Sbjct: 4237 KLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ 4295

Query: 707  DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 766
            ++   +  +++ +  L  E    L+ A +    F E    L   +E     +  I  + S
Sbjct: 4296 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPS 4352

Query: 767  -NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDCLEAKEKVHVIG 824
              +D E L+   +++ Q++  + E +  +  L  +  QL  +N E  + +E  EK     
Sbjct: 4353 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVE--EKYQKAE 4410

Query: 825  NRLKLLLKEVSRHIKELEKLLDVSS 849
            N    + +EV +    L++ +  S+
Sbjct: 4411 NMYAQIKEEVRQRALALDEAVSQST 4435



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 174/967 (17%), Positives = 371/967 (38%), Gaps = 168/967 (17%)

Query: 11   ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ--QLDKNMSSLRTWLAHIES 68
            E  A  ++  L  V+D W   L L      ++++T V  Q  QL+  +  LR W+ +   
Sbjct: 1885 EKDAKNLQKSLSSVSDTWNSRL-LHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNL 1943

Query: 69   ELAKP-----IVYDSCNS-----EEIQRKLNEQQ--------ELQRDIEKHSTGVASVLN 110
             L        I  DS N      E++++ + E++        ++Q  I +H+  ++   N
Sbjct: 1944 ILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQN 2003

Query: 111  LCEV-LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLK-IEETWRLWQKFLD 168
               + LL++      D     ++Q    +D    ++  M  E  +K +++      + L+
Sbjct: 2004 RQMLRLLNELQRSFQDI----LEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLE 2059

Query: 169  DYSRFEDWLKSSERTAAFPSSSGVIYTVA--KEELKKFEAFQRQVHECLTQLELINKQYR 226
            D      W+  +ER  A          ++  ++     +  Q  +    T    + K   
Sbjct: 2060 DLC---SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIE 2116

Query: 227  RLARENRTDSA----CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR--- 279
                EN+T  +     +L++ +H+  ++++ LQ+      + L+  +    + ET +   
Sbjct: 2117 GFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA 2176

Query: 280  -----------DSILVWLTEMDLQ----LTNIEHFSECD--------------------- 303
                       D++L W+T +       LTN+    +                       
Sbjct: 2177 AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQA 2236

Query: 304  ---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS----EPLDAAIIEEELDELRR 356
               +  + + +KA  QE+              +  +++      P +  +++++L EL+ 
Sbjct: 2237 PEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE 2296

Query: 357  YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 416
                   + E   K++    L D+         E E         W +RS   L +    
Sbjct: 2297 QYSTSLAQSEAELKQV--QTLQDELQKFLQDHKEFES--------WLERSEKELENMHKG 2346

Query: 417  SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 476
             +   +L   L+ + S  +   S         H  DL         R +    ++  D +
Sbjct: 2347 GSSPETLPSLLKRQGSFSEDVIS---------HKGDL---------RFVTISGQKVLDME 2388

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQ 536
            + +  G          + P     L ++ +K+ +  ++AL S+  +LG  L+    Q  Q
Sbjct: 2389 NSFKEG----------KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ 2438

Query: 537  TENIIRSKTPTGPELDTSYKGYMKLLGECSSS--------IDSVKRLEHKLKEEE----- 583
             +N   S        + + +   KLL +  +S        + + K+L+ +L E +     
Sbjct: 2439 FQNSADSLQAWMQACEANVE---KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 2495

Query: 584  -----------ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNS 632
                       E  P   + H  ET T  ++  ++ L      +   +++ + + Q    
Sbjct: 2496 LQKVARDIMEIEGEPAPDHRHVQET-TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQE 2554

Query: 633  DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 692
             L S+   +G+ E+ LE  Q   LS+ +  I+  +    +L++ +  +K+ + +      
Sbjct: 2555 SLESLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVT 2612

Query: 693  EFTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 751
             F + ADS  +  LQ +L++++ R++++C   +E    L+  L Q + F  +S  L   +
Sbjct: 2613 RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2672

Query: 752  ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 811
            EN    K+ ++   +  D +I     +Q+ ++  E+ + Q  + +L+ +  +L       
Sbjct: 2673 EN----KSRMLASGNQPDQDITH-FFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL 2727

Query: 812  DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL------DT 865
            D  + +++V      L+    E+ + +KE EK  D SS Q+ L  +            +T
Sbjct: 2728 DLCQHQDRV----QNLRKDFTELQKTVKEREK--DASSCQEQLDEFRKLVRTFQKWLKET 2781

Query: 866  SGSVSPT 872
             GS+ PT
Sbjct: 2782 EGSIPPT 2788



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 157/912 (17%), Positives = 368/912 (40%), Gaps = 103/912 (11%)

Query: 11   ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSS--LRTWLAHIES 68
            +    E E       ++      L+    K LKET  ++   + +MS+  L   + H++S
Sbjct: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKS 2806

Query: 69   EL----AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 124
             L    +K  + +  N +    + N   E+     +  TG  S+L      +   +   T
Sbjct: 2807 LLDDWASKGTLVEEINCKGTSLE-NLIMEITAPDSQGKTG--SILPSVGSSVGSVNGYHT 2863

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT- 183
              +   IQ    +++ ++  +  +  ER+  ++      ++   + +    WL+S E   
Sbjct: 2864 CKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2923

Query: 184  -AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRTDSACSLK 241
             +    SS       K + +  +AF  ++ +   +++ + +    L      +  A + K
Sbjct: 2924 KSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWK 2983

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-------- 293
            ++  E N RW+   +   +  R+L+        F+ A   +  WL E +L +        
Sbjct: 2984 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043

Query: 294  -TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352
              N+ +  +  VQ  +K+ +A +Q+    H ++ +  AQG         L  + +++EL 
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNE-AAQGILTGPGDVSLSTSQVQKELQ 3098

Query: 353  ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412
             + +   E+  ++     ++ +  +   ++    ++L  +  A    L     S  S +S
Sbjct: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-----SVQSAIS 3153

Query: 413  PQPSS-NLSLSLAQPLRS-----ERSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSR 463
             QP +    L     +RS     +   ++     D + +     Y   +L + LE+    
Sbjct: 3154 TQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV--- 3210

Query: 464  ALPSED-EEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQ 522
            ALP +  E+   D+   L+ A+         S + + ++ +  ++    D  + +++   
Sbjct: 3211 ALPLQGLEDLAADRINRLQAALA--------STQQFQQMFDE-LRTWLDDKQSQQAKNCP 3261

Query: 523  LGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +   L+  + Q+Q+ E   +S       L+     Y  ++ E  S + SV   E K    
Sbjct: 3262 ISAKLERLQSQLQENEEFQKS-------LNQHSGSYEVIVAEGESLLLSVPPGEEK---- 3310

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                       + + Q   + + WE L  +   ++ R+K  +QK Q++   +  +  W+ 
Sbjct: 3311 ----------RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360

Query: 643  DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 702
            D + ++ +L+   ++ D   +E  + + K +   V+ R++++  +N  +     +   + 
Sbjct: 3361 DCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 3417

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
              ++D  + +N   D V   L+   G L++   + + F E    +    + ++  K+++ 
Sbjct: 3418 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLE 3474

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKV 820
              D+ L ++   + + + ++ + E+L++ + +V  L++ +  L+ +A +G+D  +   + 
Sbjct: 3475 IFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA 3533

Query: 821  HVIGNRLKLLLKEVSRHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSV 869
             V       + + V+     +E  L           ++ S   DL      DELD  G++
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI 3588

Query: 870  SPTSGRSTPNRQ 881
                GR T + Q
Sbjct: 3589 ----GRDTDSLQ 3596



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 158/905 (17%), Positives = 352/905 (38%), Gaps = 127/905 (14%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            M  R  + +  + A+ ++ KL +V+ R++ L      +   LK+ L   +  +     L+
Sbjct: 2610 MVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQ 2669

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
             ++ +    LA     D    ++I     + QEL  ++E         L+  E L+ +  
Sbjct: 2670 QFMENKSRMLASGNQPD----QDITHFFQQIQELNLEMEDQQEN----LDTLEHLVTELS 2721

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            +C    +    Q   +NL + +  +     ER            +F      F+ WLK +
Sbjct: 2722 SCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKET 2781

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR---------- 230
            E +   P+ + +     +++++  ++         T +E IN +   L            
Sbjct: 2782 EGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDS 2840

Query: 231  ------------------------ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 266
                                    ++ T+  C +  +    N +++ L   +      L+
Sbjct: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV----NLKYEKLGGVLHERQESLQ 2896

Query: 267  HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC----DVQAKIKQLKAFQQEISLNH 322
              + + EE     +S+L WL   +  L +++  S       V+A+ +  KAF  E+  N 
Sbjct: 2897 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2956

Query: 323  NKIEQIIAQGEQLIEKSEPLDAAII----EEELDELRRYCQEVFGRVERYHKKLIRLPLP 378
             KI+++           E L   ++     +E +  ++  +E+  R ER  +  +     
Sbjct: 2957 PKIQKV----------KEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVA---- 3002

Query: 379  DDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP-QPSSNLSLSLAQPLRSERSGRDT- 436
                    R+ +LE+SA+        ++A+S L P      L + +  PL  + +  +  
Sbjct: 3003 --------RQRQLEESASHLACF---QAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051

Query: 437  PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
               V  +  E++        L  A    L                G V LS   + +  +
Sbjct: 3052 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGP-------------GDVSLSTSQVQKELQ 3098

Query: 497  A----YVKLTENAIKNTSGDHSAL--ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 550
            +    +V+LT+     +S    A+   +Q ++L + L +    + Q  + ++S   T PE
Sbjct: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPE 3157

Query: 551  LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE---ESLPGFVNLHSTETQTAGVIDRWE 607
                     + L E S     +++L+H++KE +   + L   +     + +    ++   
Sbjct: 3158 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVA 3211

Query: 608  L----LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            L    L+  A  +  R++  L   QQF    + +  WL D  ++ +Q +   +S  ++ +
Sbjct: 3212 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD--KQSQQAKNCPISAKLERL 3269

Query: 664  ELQIKKLKELQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
            + Q+++ +E QK+++       ++     S   +    +E R LQ++L ++   W+ +  
Sbjct: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329

Query: 722  LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
               + +  L+D + + Q +      L+  +E+   + +E   +   LD   L+     L+
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDPVQLE---SSLL 3383

Query: 782  QIKHELLESQLRVASLQ--DMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
            + K  L E + R + L+  + +  +L+N+   D    +++   I   +  + +E+     
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG 3443

Query: 840  ELEKL 844
             LE++
Sbjct: 3444 SLEEM 3448


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  120 bits (302), Expect = 5e-27
 Identities = 175/943 (18%), Positives = 380/943 (40%), Gaps = 107/943 (11%)

Query: 8    ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE 67
            A  +  A EI+ KL ++   W+ +      R  K  + L   ++   +M++L T +   +
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4066

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
                  IV+D  +       + +Q E    I++ + G+   L    +L  D      + E
Sbjct: 4067 D-----IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETE 4121

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
               ++++   ++  W N+     ER  K+E+  +   ++ D      DWL ++       
Sbjct: 4122 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4181

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLKQMVH 245
               G      K++L + + F+ +V++   ++E +N Q   + ++  + TD    +++ + 
Sbjct: 4182 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLT 4240

Query: 246  EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD-- 303
            E    W+NL +++     +L+  +    +F+ A + ++ WLT  + +L + +     D  
Sbjct: 4241 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPK 4299

Query: 304  -VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
             ++ ++ +    + ++  +   +E +   G +L+E S   DA+ +   L+ + +  + V 
Sbjct: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359

Query: 363  GRVERYHKKL---------IRLPLPDDEHDLSDRELELEDS--------AALSDLHWHDR 405
             + E   ++L             + D   +L+  E +L  S         A   L  H  
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4419

Query: 406  SADSLLSPQPSSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAM 461
                L + + + N  L   + +   R    SG  T  SV  +  +W        + +S +
Sbjct: 4420 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4479

Query: 462  SRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAI---KNTSGDHSALES 518
              AL    E     ++F     +    + I   P   +    + I   K  + + +A   
Sbjct: 4480 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 4539

Query: 519  QIRQLGKALDDSRFQIQQT----------------ENIIRSKTPTGPELDTS-------Y 555
            QI +L +  +  +F  Q+                 E +++     G  LD +       +
Sbjct: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599

Query: 556  KGYMKLLG-------------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 602
            + + KL+              E S+  D +K    K KE +++L G   ++ T  +T   
Sbjct: 4600 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRA 4659

Query: 603  I---------------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
            +                     D+W+ +  +++ ++ ++++ L    QF   L ++  WL
Sbjct: 4660 LKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWL 4719

Query: 642  GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
               E +L + Q   +  D+  +   +   K  QK +  R   +  +     E  +    +
Sbjct: 4720 YKVEPQLAEDQ--PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDD 4777

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKN 759
            +  ++ +L +++ RWD VC L    +  L+ AL Q + F +  H LL  L   ++  R  
Sbjct: 4778 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 4837

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KE 818
              +P D+    + L D HK+ M+   ++ E ++ V S   M  ++++     DC+   K 
Sbjct: 4838 GALPDDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKH 4892

Query: 819  KVHVIGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 857
             + +I  R + +L    +H + LE  L   V++++  ++L +W
Sbjct: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 4935



 Score =  113 bits (283), Expect = 8e-25
 Identities = 169/806 (20%), Positives = 335/806 (41%), Gaps = 86/806 (10%)

Query: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
            L KA+ E+    I   L ++   W++L + IA R  KL+  L+A+ Q    +  L +WL 
Sbjct: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282

Query: 65   HIES--ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
            H E   +  +PI   S + + I+ +L +   L+ D+  H   V +V      LL   ++ 
Sbjct: 4283 HTEELLDAQRPI---SGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELL---ESS 4336

Query: 123  ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            A D +  S++     +++ W ++   + ER  +++ T +  Q F   +S  ED+L    R
Sbjct: 4337 AGD-DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGF---HSEIEDFLLELTR 4392

Query: 183  TAAFPSSS---GVIYTVAKEEL-KKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
              +  S+S   G +   A+E+L    E + +   +  T  +L++K    L   + + S  
Sbjct: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4452

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT--EMDLQLTNI 296
              +Q V    Q+W  +  ++     +L+  +    EF+ +    + WLT  E  L + + 
Sbjct: 4453 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASP 4512

Query: 297  EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                   V ++I++ K F  E++ + ++I ++   G QL   S+  D  +I+  L  ++ 
Sbjct: 4513 PSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQS 4572

Query: 357  YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 416
              ++V  R     + L          D + +  +    A    + W + +   L S    
Sbjct: 4573 RWEKVVQRSIERGRSL----------DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622

Query: 417  SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-RDLESAMSRALPSEDEEGQDD 475
            SN    +   L   +  + T      +       YD + R   +   + L  ED +  D+
Sbjct: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPV-------YDTTIRTGRALKEKTLLPEDSQKLDN 4675

Query: 476  KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535
               +L       D +  +S E   KL E  +            Q     +AL D  +++ 
Sbjct: 4676 ---FLGEVRDKWDTVCGKSVERQHKLEEALL---------FSGQFMDALQALVDWLYKV- 4722

Query: 536  QTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 589
              E  +    P   +LD       ++K + K LG+ + ++  +KR   +L E       +
Sbjct: 4723 --EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 4780

Query: 590  VNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
            V     E  T     RW+ +   ++SK+ R++Q L++ + F   ++ +  WL + E+ L 
Sbjct: 4781 VKGQLQELST-----RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835

Query: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS--------INLCSPEFTQADSKE 701
               R  L  D + ++  I   KE  K V+ ++  + S        + +C P+        
Sbjct: 4836 --FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITT---- 4889

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE----NIDRR 757
               ++  ++ +  R++ V +  ++ +  L+ AL +     E+   LL  ++     + +R
Sbjct: 4890 ---IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQR 4946

Query: 758  KNEIVPIDSNLD-AEILQDHHKQLMQ 782
              E  PI  N+D  + L   H+  M+
Sbjct: 4947 DQE--PIPQNIDRVKALIAEHQTFME 4970



 Score =  100 bits (250), Expect = 5e-21
 Identities = 147/795 (18%), Positives = 313/795 (39%), Gaps = 62/795 (7%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQL----DKNMSSLRTW 62
            K  +  +   +E K  K  + +  + + +  R   L E +    Q+    DK    L T 
Sbjct: 3890 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLET- 3948

Query: 63   LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
            L ++ S L  P +  +   ++I+  +++ +    ++EK      ++    E L+      
Sbjct: 3949 LENLSSRLRMPPLIPA-EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4007

Query: 123  ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
              D     IQ     +   W +I A + ER +K  +   L +KF  D +     +K ++ 
Sbjct: 4008 DKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD 4067

Query: 183  TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ 242
                  S G+  ++ K++++  E  + +      +LE I      L           +++
Sbjct: 4068 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4127

Query: 243  MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE- 301
             + E N  W+NL K     L +L+  +    +++    ++  WL    ++L  +      
Sbjct: 4128 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4187

Query: 302  -CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK-SEPLDAAIIEEELDELRRYCQ 359
               V+ ++ ++K F+ E+     ++E++  QGE +++K ++  D  II E L EL+   +
Sbjct: 4188 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4247

Query: 360  EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
             +  ++     KL                       AL  L     + + L+S    +  
Sbjct: 4248 NLGEKIAHRQHKL---------------------EGALLALGQFQHALEELMSWLTHTEE 4286

Query: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
             L   +P+  +            I +E    + L  D+  A    + + ++ G +     
Sbjct: 4287 LLDAQRPISGDPK---------VIEVELAKHHVLKNDV-LAHQATVETVNKAGNE----L 4332

Query: 480  LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQ---LGKALDDSRFQIQQ 536
            L  + G     +    EA  +  E+ ++ T      L+S ++Q       ++D   ++ +
Sbjct: 4333 LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTR 4392

Query: 537  TENIIRSKTPTG-------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 589
             E+ + +  PTG        +LDT  + Y +L  +  +    + +    L   ++S  G 
Sbjct: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSG- 4451

Query: 590  VNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELE 649
                 TE   A +  +W ++ ++   ++ ++++ L    +F + L     WL   E+ L 
Sbjct: 4452 ---SKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLN 4508

Query: 650  QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDR 708
                  L   + T+  QI++ K     V+  +  I+ ++    +      K+   L ++ 
Sbjct: 4509 IASPPSLI--LNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNL 768
            L  +  RW++V     E    L DA  + + FHE    L+  LE+ +   +  + I ++ 
Sbjct: 4567 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 4626

Query: 769  DAEILQ-DHHKQLMQ 782
            D   LQ   HK+  +
Sbjct: 4627 DKIKLQLSKHKEFQK 4641



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 152/861 (17%), Positives = 350/861 (40%), Gaps = 69/861 (8%)

Query: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
            +  A  +     +E+ + ++N RW  L   +A R+ +L+E L+   +    +  L +WLA
Sbjct: 3235 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294

Query: 65   HIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
              E  +A  KP    S   + ++ ++ EQ+ LQR ++     V       ++L  +    
Sbjct: 3295 DTEELIANQKP---PSAEYKVVKAQIQEQKLLQRLLDDRKATV-------DMLQAEGGRI 3344

Query: 123  ATDAECDSIQQAT---RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            A  AE    ++ T    +L+ RW  + + +  R+ ++E+   L ++F +      D+L  
Sbjct: 3345 AQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSV 3404

Query: 180  SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +E+  A     G      ++++ + +A +  +    T +    K  + L+          
Sbjct: 3405 TEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGV 3464

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI--E 297
            L + +     R+  +Q R       L   +     F      +L WL E++ +L+++  +
Sbjct: 3465 LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVK 3524

Query: 298  HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 357
             F +  +  +     A  +EI      ++Q I  G+ L++++   +  +I+E+LD ++  
Sbjct: 3525 DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTR 3584

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
              ++     +  + L +            R+L  +  +   +L    R  +  L+   S 
Sbjct: 3585 YADITVTSSKALRTLEQA-----------RQLATKFQSTYEELTGWLREVEEELA--TSG 3631

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
              S +  Q  + ++  ++    V    L  D   ++SR    A+   +P    EG D   
Sbjct: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR----ALLELVPWRAREGLDK-- 3685

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQT 537
                        ++ ++ E Y KL  + I     +  A   + +Q  +A D     + +T
Sbjct: 3686 ------------LVSDANEQY-KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAET 3732

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE-----HKLKEEEESLPGFVNL 592
            +  + +  P   E D +     +L  + + SID ++  +        + E     G    
Sbjct: 3733 KRKLMALGPIRLEQDQT---TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 3789

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +T  +I ++E +      +  R+++      QF      +  W+ +T   + QL 
Sbjct: 3790 TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLP 3849

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
                + D + +  Q +++++L++++   K  I  +    P+  + + +E   ++++  + 
Sbjct: 3850 --SPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKA 3907

Query: 713  NGRWDRVCSLLEEWRGLLQDAL---MQCQGFHEMSHGLLLMLENIDRRKN--EIVPIDSN 767
               + ++   + +    L +A+    Q   FH+    +L  LEN+  R     ++P + +
Sbjct: 3908 ENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVD 3967

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
               E + D+    +    EL + Q    +L+    +L+  ++G D   A +++    +++
Sbjct: 3968 KIRECISDNKSATV----ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4023

Query: 828  KLLLKEVSRHIKELE-KLLDV 847
                +++    +E E K LDV
Sbjct: 4024 VFFWEDIKARAEEREIKFLDV 4044



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 172/929 (18%), Positives = 368/929 (39%), Gaps = 85/929 (9%)

Query: 15   SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 74
            S+++ +L  +N +W  L D + +R  ++ + +V   Q  + +  L   +  +   L+   
Sbjct: 2589 SQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 2648

Query: 75   VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 134
               S   E ++++L E  E++ D+E+    V     LC+ L             D +++ 
Sbjct: 2649 AI-STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL---SVLIGEQYLKDELKKR 2704

Query: 135  TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGV 192
               +    + +  ++ +R  +++      Q+F   +     WL  K S++    P S+ +
Sbjct: 2705 LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKL 2764

Query: 193  IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL------ARENRTDSACSLKQMVHE 246
                 + +L++ E FQ+ +++     E+I  +   L        E RT     L+  + E
Sbjct: 2765 --ERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT-----LQNQLVE 2817

Query: 247  GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDVQ 305
                W+ L K+      RLK  + + ++++   + ++ W+ +   +++ +        ++
Sbjct: 2818 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLE 2877

Query: 306  AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAI------IEEELDELRRYCQ 359
            + + + KA   E+    + +E + +  + LI  SE  +  I      I + +D +    Q
Sbjct: 2878 SSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQ 2937

Query: 360  EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
               G +E   ++L        E   S + +E +   A   L   D      L  Q  SN 
Sbjct: 2938 AKTGSLEEMTQRL-------REFQESFKNIEKKVEGAKHQLEIFDA-----LGSQACSNK 2985

Query: 420  SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 479
            +L   + LR+++             LE   DY  +       ++ L  +  +G D     
Sbjct: 2986 NL---EKLRAQQEVLQA--------LEPQVDYLRN------FTQGLVEDAPDGSDASQLL 3028

Query: 480  LRGAVGLSDVM-IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD--DSRFQIQQ 536
             +  V   + + + +   +   + EN ++     H  +     QL    D  D    I +
Sbjct: 3029 HQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGR 3088

Query: 537  TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 596
              + ++S+      L  +    +KL  E S +        H L+EE     G ++L   +
Sbjct: 3089 DTDSLQSQIED-VRLFLNKIHVLKLDIEASEA-----ECRHMLEEE-----GTLDLLGLK 3137

Query: 597  TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE- 655
             +   +  +   L  +  +++ +++  L + + F   L      L D     E+ + L+ 
Sbjct: 3138 RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQW 3193

Query: 656  -LSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQADSKES--RDLQDRLSQ 711
             + T+++ I  Q+   K  QK  VD  +  +  +N       Q+  K+   + L+  + +
Sbjct: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253

Query: 712  MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 771
            +N RW+ +   + +    LQ+AL+ C  F +    LL  L + +       P  +     
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313

Query: 772  ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 831
              Q   ++L+Q    L + +  V  LQ    ++  +AE  D  +   ++  + +R   LL
Sbjct: 3314 KAQIQEQKLLQ--RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3371

Query: 832  KEVSRHIKELEKLLDVS----SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGK 887
             + +   K+LE +L ++     + + +S + S  E   + S  P   ++   +Q+  R K
Sbjct: 3372 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS-EPVGTQTAKIQQQIIRHK 3430

Query: 888  CSLSQPGPSVSSPHSRSTKGGSDSSLSEP 916
                      +  H     G S SSL+ P
Sbjct: 3431 ALEEDIENHATDVHQAVKIGQSLSSLTSP 3459



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 80/375 (21%), Positives = 167/375 (44%), Gaps = 12/375 (3%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G  L ++S    AS +  +L  +N  W+ +L     R ++L+ TL   Q     +     
Sbjct: 4329 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4388

Query: 62   WLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
             L  +ES+L+  KP        E  + +L+   EL   ++        +L+   ++L   
Sbjct: 4389 ELTRMESQLSASKPT---GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4445

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            D   + ++ +   Q+   L+++W  + +   ER+ K+EE   L  +F +    F +WL  
Sbjct: 4446 DDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTL 4502

Query: 180  SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
            +E++    S   +I      ++++ + F  +V+    Q+  +++   +L   ++      
Sbjct: 4503 AEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL 4562

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEH 298
            +K ++     RW+ + +R     R L     + ++F  A   ++ WL + +  L + +E 
Sbjct: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622

Query: 299  FSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRR 356
             ++ D ++ ++ + K FQ+ +       +  I  G  L EK+  P D+  ++  L E+R 
Sbjct: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRD 4682

Query: 357  YCQEVFGR-VERYHK 370
                V G+ VER HK
Sbjct: 4683 KWDTVCGKSVERQHK 4697



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 161/865 (18%), Positives = 338/865 (39%), Gaps = 90/865 (10%)

Query: 1    MGERLAKASHESKA--SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSS 58
            + ++  K +   KA   ++E  LG+V D ++ L        K L +   A ++ +     
Sbjct: 3143 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKL--------KGLNDATTAAEEAEALQWV 3194

Query: 59   LRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
            + T +  I  +LA   ++     + +Q KL +   L + + + S G             D
Sbjct: 3195 VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAG------------KD 3241

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
            CD    + + + I       + RW  +     +R  +++E      KF D       WL 
Sbjct: 3242 CDVQGLEHDMEEI-------NARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             +E   A        Y V K ++++ +  QR + +    ++++  +  R+A+        
Sbjct: 3295 DTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3354

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
             +   +     RW  L  +  +  ++L+  +   ++F    + I  +L+  + +L N E 
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414

Query: 299  F--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
                   +Q +I + KA +++I  +   + Q +  G+ L   + P +  ++ E++D L+ 
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3474

Query: 357  YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 416
               E+  R  R    L        +  LS+  L  ED   +  L+W     D L     S
Sbjct: 3475 RYSEIQDRCCRKAALL--------DQALSNARLFGEDEVEV--LNWLAEVEDKL-----S 3519

Query: 417  SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 476
            S       Q +   +         D + L  +   +  ++++ A+        + GQ   
Sbjct: 3520 SVFVKDFKQDVLHRQ-------HADHLALN-EEIVNRKKNVDQAI--------KNGQ--- 3560

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI-- 534
               L+   G   ++I E  +  +K     I  TS        Q RQL      +  ++  
Sbjct: 3561 -ALLKQTTGEEVLLIQEKLDG-IKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTG 3618

Query: 535  ---QQTENIIRS--KTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 586
               +  E +  S  ++PTG   P+     K   K + E    +D+V  +   L E    L
Sbjct: 3619 WLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE----L 3674

Query: 587  PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 646
              +      +   +   ++++L+      +   +   +Q+ QQ+    ++  AW+ +T+ 
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKR 3734

Query: 647  ELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQ 706
            +L  L  + L  D  T +LQ++K   +   + H+ ++    +  S  F     ++   LQ
Sbjct: 3735 KLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ 3793

Query: 707  DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 766
            ++   +  +++ +  L  E    L+ A +    F E    L   +E     +  I  + S
Sbjct: 3794 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPS 3850

Query: 767  -NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDCLEAKEKVHVIG 824
              +D E L+   +++ Q++  + E +  +  L  +  QL  +N E  + +E  EK     
Sbjct: 3851 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVE--EKYQKAE 3908

Query: 825  NRLKLLLKEVSRHIKELEKLLDVSS 849
            N    + +EV +    L++ +  S+
Sbjct: 3909 NMYAQIKEEVRQRALALDEAVSQST 3933



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 168/966 (17%), Positives = 370/966 (38%), Gaps = 160/966 (16%)

Query: 12   SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK-----------NMSSLR 60
            S +  I  +   +  R+  L+ L    VK + + L  +++ +K            +  L 
Sbjct: 1376 SSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELL 1435

Query: 61   TWLAHI-ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
             W++ +  +   K    ++  S +I++ + EQQ L  ++      V+  +   ++ L   
Sbjct: 1436 GWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKH 1495

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMER--RLKIEETWRLWQKFLDD-----YSR 172
                ++ E   I +    L++ + ++C  S  +  +L+ +   +  QK L       + +
Sbjct: 1496 GHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQ 1555

Query: 173  FED---WLKSSERTAAFPSSSGVIYTVA--KEELKKFEAFQRQVHECLTQLELINKQYRR 227
             ED   W+  +ER  A          ++  ++     +  Q  +    T    + K    
Sbjct: 1556 LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 1615

Query: 228  LARENRTDSA----CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR---- 279
               EN+T  +     +L++ +H+  ++++ LQ+      + L+  +    + ET +    
Sbjct: 1616 FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA 1675

Query: 280  ----------DSILVWLTEMDLQ----LTNIEHFSECD---------------------- 303
                      D++L W+T +       LTN+    +                        
Sbjct: 1676 KELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP 1735

Query: 304  --VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS----EPLDAAIIEEELDELRRY 357
              +  + + +KA  QE+              +  +++      P +  +++++L EL+  
Sbjct: 1736 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQ 1795

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 417
                  + E   K++    L D+         E E         W +RS   L +     
Sbjct: 1796 YSTSLAQSEAELKQV--QTLQDELQKFLQDHKEFES--------WLERSEKELENMHKGG 1845

Query: 418  NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
            +   +L   L+ + S  +   S         H  DL         R +    ++  D ++
Sbjct: 1846 SSPETLPSLLKRQGSFSEDVIS---------HKGDL---------RFVTISGQKVLDMEN 1887

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQT 537
             +  G          + P     L ++ +K+ +  ++AL S+  +LG  L+    Q  Q 
Sbjct: 1888 SFKEG----------KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQF 1937

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSS--------IDSVKRLEHKLKEEE------ 583
            +N   S        + + +   KLL +  +S        + + K+L+ +L E +      
Sbjct: 1938 QNSADSLQAWMQACEANVE---KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 1994

Query: 584  ----------ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 633
                      E  P   + H  ET T  ++  ++ L      +   +++ + + Q     
Sbjct: 1995 QKVARDIMEIEGEPAPDHRHVQET-TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 693
            L S+   +G+ E+ LE  Q   LS+ +  I+  +    +L++ +  +K+ + +       
Sbjct: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTR 2111

Query: 694  FTQ-ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 752
            F + ADS  +  LQ +L++++ R++++C   +E    L+  L Q + F  +S  L   +E
Sbjct: 2112 FMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFME 2171

Query: 753  NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD 812
            N    K+ ++   +  D +I     +Q+ ++  E+ + Q  + +L+ +  +L       D
Sbjct: 2172 N----KSRMLASGNQPDQDITH-FFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALD 2226

Query: 813  CLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL------DTS 866
              + +++V      L+    E+ + +KE EK  D SS Q+ L  +            +T 
Sbjct: 2227 LCQHQDRV----QNLRKDFTELQKTVKEREK--DASSCQEQLDEFRKLVRTFQKWLKETE 2280

Query: 867  GSVSPT 872
            GS+ PT
Sbjct: 2281 GSIPPT 2286



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 157/912 (17%), Positives = 368/912 (40%), Gaps = 103/912 (11%)

Query: 11   ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSS--LRTWLAHIES 68
            +    E E       ++      L+    K LKET  ++   + +MS+  L   + H++S
Sbjct: 2245 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKS 2304

Query: 69   EL----AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 124
             L    +K  + +  N +    + N   E+     +  TG  S+L      +   +   T
Sbjct: 2305 LLDDWASKGTLVEEINCKGTSLE-NLIMEITAPDSQGKTG--SILPSVGSSVGSVNGYHT 2361

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT- 183
              +   IQ    +++ ++  +  +  ER+  ++      ++   + +    WL+S E   
Sbjct: 2362 CKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2421

Query: 184  -AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRTDSACSLK 241
             +    SS       K + +  +AF  ++ +   +++ + +    L      +  A + K
Sbjct: 2422 KSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWK 2481

Query: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-------- 293
            ++  E N RW+   +   +  R+L+        F+ A   +  WL E +L +        
Sbjct: 2482 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541

Query: 294  -TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352
              N+ +  +  VQ  +K+ +A +Q+    H ++ +  AQG         L  + +++EL 
Sbjct: 2542 DPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNE-AAQGILTGPGDVSLSTSQVQKELQ 2596

Query: 353  ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412
             + +   E+  ++     ++ +  +   ++    ++L  +  A    L     S  S +S
Sbjct: 2597 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-----SVQSAIS 2651

Query: 413  PQPSS-NLSLSLAQPLRS-----ERSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSR 463
             QP +    L     +RS     +   ++     D + +     Y   +L + LE+    
Sbjct: 2652 TQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV--- 2708

Query: 464  ALPSED-EEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQ 522
            ALP +  E+   D+   L+ A+         S + + ++ +  ++    D  + +++   
Sbjct: 2709 ALPLQGLEDLAADRINRLQAALA--------STQQFQQMFDE-LRTWLDDKQSQQAKNCP 2759

Query: 523  LGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE 582
            +   L+  + Q+Q+ E   +S       L+     Y  ++ E  S + SV   E K    
Sbjct: 2760 ISAKLERLQSQLQENEEFQKS-------LNQHSGSYEVIVAEGESLLLSVPPGEEK---- 2808

Query: 583  EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 642
                       + + Q   + + WE L  +   ++ R+K  +QK Q++   +  +  W+ 
Sbjct: 2809 ----------RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858

Query: 643  DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 702
            D + ++ +L+   ++ D   +E  + + K +   V+ R++++  +N  +     +   + 
Sbjct: 2859 DCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 2915

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
              ++D  + +N   D V   L+   G L++   + + F E    +    + ++  K+++ 
Sbjct: 2916 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLE 2972

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKV 820
              D+ L ++   + + + ++ + E+L++ + +V  L++ +  L+ +A +G+D  +   + 
Sbjct: 2973 IFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA 3031

Query: 821  HVIGNRLKLLLKEVSRHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSV 869
             V       + + V+     +E  L           ++ S   DL      DELD  G++
Sbjct: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI 3086

Query: 870  SPTSGRSTPNRQ 881
                GR T + Q
Sbjct: 3087 ----GRDTDSLQ 3094



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 158/905 (17%), Positives = 352/905 (38%), Gaps = 127/905 (14%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            M  R  + +  + A+ ++ KL +V+ R++ L      +   LK+ L   +  +     L+
Sbjct: 2108 MVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQ 2167

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
             ++ +    LA     D    ++I     + QEL  ++E         L+  E L+ +  
Sbjct: 2168 QFMENKSRMLASGNQPD----QDITHFFQQIQELNLEMEDQQEN----LDTLEHLVTELS 2219

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            +C    +    Q   +NL + +  +     ER            +F      F+ WLK +
Sbjct: 2220 SCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKET 2279

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR---------- 230
            E +   P+ + +     +++++  ++         T +E IN +   L            
Sbjct: 2280 EGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDS 2338

Query: 231  ------------------------ENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 266
                                    ++ T+  C +  +    N +++ L   +      L+
Sbjct: 2339 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV----NLKYEKLGGVLHERQESLQ 2394

Query: 267  HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC----DVQAKIKQLKAFQQEISLNH 322
              + + EE     +S+L WL   +  L +++  S       V+A+ +  KAF  E+  N 
Sbjct: 2395 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2454

Query: 323  NKIEQIIAQGEQLIEKSEPLDAAII----EEELDELRRYCQEVFGRVERYHKKLIRLPLP 378
             KI+++           E L   ++     +E +  ++  +E+  R ER  +  +     
Sbjct: 2455 PKIQKV----------KEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVA---- 2500

Query: 379  DDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP-QPSSNLSLSLAQPLRSERSGRDT- 436
                    R+ +LE+SA+        ++A+S L P      L + +  PL  + +  +  
Sbjct: 2501 --------RQRQLEESASHLACF---QAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 2549

Query: 437  PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 496
               V  +  E++        L  A    L                G V LS   + +  +
Sbjct: 2550 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGP-------------GDVSLSTSQVQKELQ 2596

Query: 497  A----YVKLTENAIKNTSGDHSAL--ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 550
            +    +V+LT+     +S    A+   +Q ++L + L +    + Q  + ++S   T PE
Sbjct: 2597 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPE 2655

Query: 551  LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE---ESLPGFVNLHSTETQTAGVIDRWE 607
                     + L E S     +++L+H++KE +   + L   +     + +    ++   
Sbjct: 2656 ------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVA 2709

Query: 608  L----LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
            L    L+  A  +  R++  L   QQF    + +  WL D  ++ +Q +   +S  ++ +
Sbjct: 2710 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD--KQSQQAKNCPISAKLERL 2767

Query: 664  ELQIKKLKELQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
            + Q+++ +E QK+++       ++     S   +    +E R LQ++L ++   W+ +  
Sbjct: 2768 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 2827

Query: 722  LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
               + +  L+D + + Q +      L+  +E+   + +E   +   LD   L+     L+
Sbjct: 2828 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDPVQLE---SSLL 2881

Query: 782  QIKHELLESQLRVASLQ--DMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
            + K  L E + R + L+  + +  +L+N+   D    +++   I   +  + +E+     
Sbjct: 2882 RSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG 2941

Query: 840  ELEKL 844
             LE++
Sbjct: 2942 SLEEM 2946



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 51/245 (20%), Positives = 106/245 (43%), Gaps = 34/245 (13%)

Query: 566  SSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 625
            SSS+ +++   + L E+ + + G   ++  + +T  VI R  +  A+ L K   +K  L 
Sbjct: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVR-SIQDAELLVKGYEIK--LS 1181

Query: 626  KWQQFNSDLNSIWA-------WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 678
            + +   +DL+++ A       WL D +++      L+               +E+ KA  
Sbjct: 1182 QEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLD---------------EEIAKA-- 1224

Query: 679  HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 738
              K +   ++  +PE     + +    Q++ SQ+  RW RV + LE  +  L +++ +  
Sbjct: 1225 --KVVAEQMSRLTPE----RNLDLERYQEKGSQLQERWHRVIAQLEIRQSEL-ESIQEVL 1277

Query: 739  GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQ 798
            G +   HG L+        + E++      D+ +L +   Q   +  E+  +Q ++   Q
Sbjct: 1278 GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQ 1337

Query: 799  DMSCQ 803
              S Q
Sbjct: 1338 KFSQQ 1342



 Score = 35.4 bits (80), Expect = 0.26
 Identities = 58/267 (21%), Positives = 103/267 (38%), Gaps = 25/267 (9%)

Query: 564 ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 623
           E  SS+   +  E K+ +         N H++  +T G ++       +  S  +R  Q+
Sbjct: 631 ELGSSVKEARLYEGKMSQ---------NFHTSYAETLGKLETQYCKLKETSSFRMRHLQS 681

Query: 624 LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-ELQKAVDHRKA 682
           L K   F S   +   WL + EEE       + +++I        +L  EL++  D  ++
Sbjct: 682 LHK---FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRS 738

Query: 683 IILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE 742
           +  +  L S E   A  K++ +      Q   +W +   L  E       A  Q   F  
Sbjct: 739 LQDTAELLSLENHPA--KQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQ---FFS 793

Query: 743 MSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 802
            +  L   L N+          D N     L+D  +  M  K +L++S+  VASL   S 
Sbjct: 794 DARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSK 853

Query: 803 QLLVNAEGTDCLEAKEKVHVIGNRLKL 829
            ++        L+ +   HV+ N + +
Sbjct: 854 TIVQ-------LKPRSPDHVLKNTISV 873



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)

Query: 633 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 692
           +L  ++  L   EE   +L+R E   D+ ++ELQ++  + +  +V+   + +    L   
Sbjct: 585 NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641

Query: 693 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 752
                + K S++     ++  G+ +     L+E        L     F   +   L+ L 
Sbjct: 642 ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697

Query: 753 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 811
             +  +      D+N +    +++  +L     EL E Q    SLQD +  L L N    
Sbjct: 698 EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754

Query: 812 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 857
             +EA    V      +K L   V +H+KE        S  ++L S+
Sbjct: 755 QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 1829 RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 1888

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 1889 EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 1936

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 1937 VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 1991

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 1992 YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 2047

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 2048 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 2107

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 2108 FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2166

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 2167 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2226

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 2227 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 2285

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 2286 KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 2332

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 2333 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2392

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 2393 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 2451

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 2452 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 2511

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 2512 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 2571

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 2572 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 2625

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2626 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2677



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 154/870 (17%), Positives = 354/870 (40%), Gaps = 104/870 (11%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            + ++K +    + + + +  ++  RW+ L   +    +KL+E +  ++++  ++ +L+ W
Sbjct: 996  KEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKW 1055

Query: 63   LAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +A ++  L +  P + D   SE ++++L + + L  DI+     + SV    + + ++  
Sbjct: 1056 MAEVDVFLKEEWPALGD---SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-- 1110

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A       ++   + L+ +W ++C     R+  ++           D S   +W+  +
Sbjct: 1111 --AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQA 1168

Query: 181  -----ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
                 ER   + +   +   V + +  K EA Q++      +++L+ +    +  +    
Sbjct: 1169 EEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE-----AKVKLLTESVNSVIAQAPPV 1223

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
            +  +LK+ +      +  L  R+    + L+       E  +  +    WL E++ +L  
Sbjct: 1224 AQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKT 1283

Query: 296  IEHF--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             E+      ++   +  L+   +    N N+I +I+A   Q +     +D  +I EEL+ 
Sbjct: 1284 TENIPGGAEEISEVLDSLENLMRHSEDNPNQI-RILA---QTLTDGGVMD-ELINEELET 1338

Query: 354  LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 413
                 +E+       H++ +R     ++   S +E E         L + D+   + ++ 
Sbjct: 1339 FNSRWREL-------HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD 1391

Query: 414  QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 473
            +  +      AQ ++S+ +  +       I LE    ++  ++   A  R L   D    
Sbjct: 1392 KVDAAQMPQEAQKIQSDLTSHE-------ISLEEMKKHNQGKE---AAQRVLSQID---- 1437

Query: 474  DDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSA-LESQIRQLGKALDDSRF 532
                                   A  KL + ++K       A  E ++++    LD+ + 
Sbjct: 1438 ----------------------VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKM 1475

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
             +   E     +     +L+     Y K L E  S ++ V +   ++ +++++     N 
Sbjct: 1476 HLPALETKSVEQEVVQSQLNHCVNLY-KSLSEVKSEVEMVIKTGRQIVQKKQT----ENP 1530

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +   +   +  L A+   ++ ++++ L+  ++   ++N +  WL  T+ EL +  
Sbjct: 1531 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1590

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             +E       ++ ++   K  QK ++ +K  + SI            K+   ++D+LS +
Sbjct: 1591 AVEGMP--SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL 1648

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD-AE 771
            N  W  V S  EEW  LL +     + F           +N+D     I+  D+ LD +E
Sbjct: 1649 NSNWIAVTSRAEEWLNLLLEYQKHMETFD----------QNVDHITKWIIQADTLLDESE 1698

Query: 772  ILQDHHKQ--LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC--------LEAKEKVH 821
              +   K+  L ++K EL + + +V S +D +  L+ N  G  C         E   +  
Sbjct: 1699 KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN-RGDHCRKLVEPQISELNHRFA 1757

Query: 822  VIGNRLK-----LLLKEVSRHIKELEKLLD 846
             I +R+K     + LKE+ +   +++KLL+
Sbjct: 1758 AISHRIKTGKASIPLKELEQFNSDIQKLLE 1787



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 2532 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 2591

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 2592 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2643

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 2644 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2699

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 2700 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 2754

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 2755 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2814

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 2815 LKDDELS 2821



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 163/904 (18%), Positives = 354/904 (39%), Gaps = 161/904 (17%)

Query: 14   ASEIEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMSSLRTWLAHIE 67
            A  I+    ++N RW     L++ R+  L+    ++A    +QQL++  ++   WL    
Sbjct: 790  ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 849

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
            +  ++P    S   +  + ++N    LQ  IE+        L +  + L +        +
Sbjct: 850  TTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALKEKGQGPMFLD 900

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
             D +   T +  + + ++ A   E +   +    +  ++ +  S    W++ SE   + P
Sbjct: 901  ADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIP 957

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEG 247
              S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +   +    E 
Sbjct: 958  QLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI 1017

Query: 248  NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI-EHFSECDVQA 306
              RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L        + ++  
Sbjct: 1018 EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1077

Query: 307  K-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR----RYCQEV 361
            K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL       CQ+V
Sbjct: 1078 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV 1137

Query: 362  FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSLLSPQPSSNLS 420
            + R E     L             ++ + L+    LS++H W  ++ +  L         
Sbjct: 1138 YARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEYL--------- 1173

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
                                     E D +Y    +L+ A+     +++E  Q +    L
Sbjct: 1174 -------------------------ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKL 1208

Query: 481  RGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE----------SQI 520
                 ++ V+    P + EA  K  E    N        +G    LE          S +
Sbjct: 1209 L-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYL 1267

Query: 521  RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLK 580
             +  K L++  F+++ TENI     P G E             E S  +DS   LE+ ++
Sbjct: 1268 EKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLDS---LENLMR 1306

Query: 581  EEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKELRMKQNLQKWQ 628
              E++ P  + + +      GV+D            RW  L  +A+ ++  ++Q++Q  Q
Sbjct: 1307 HSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ 1365

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            +              TE+ L  +Q      D Q       K+   Q   + +K   +  +
Sbjct: 1366 E--------------TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSD 1408

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
            L S E +  + K+    ++          RV S ++  +  LQD  M+ + F + ++   
Sbjct: 1409 LTSHEISLEEMKKHNQGKEAAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 1461

Query: 749  LMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
             + E+   +D  K  +  +++ +++ E++Q      + +   L E +  V  +     Q+
Sbjct: 1462 RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 1521

Query: 805  LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSA 860
            +   +  +  E  E+V  +      L  +V+   ++LEK L +S   +     L+ W +A
Sbjct: 1522 VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 1581

Query: 861  DELD 864
             +++
Sbjct: 1582 TDME 1585



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 2158 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2217

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 2218 WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 2271

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 2272 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 2331

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 2332 LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 2391

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 2392 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2450

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 2451 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2510

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 2511 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 2570

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 2571 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 2623

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 2624 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 2658

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 2659 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2715

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 2716 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2775

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 2776 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 2833

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 2834 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2893

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 2894 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2953

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2954 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2994



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 177/953 (18%), Positives = 360/953 (37%), Gaps = 111/953 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++S +   + +E +L  + DRW ++      R   L++ L+  Q+L +       WL+  
Sbjct: 511  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 570

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            E  + K       +  E+   L +   L+ D+EK    +  + +L + LL       +  
Sbjct: 571  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLL-------STL 623

Query: 127  ECDSIQQATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            +  S+ Q T     N  R W N+     +   +I +     Q  L   +  E     + R
Sbjct: 624  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683

Query: 183  TAAF-----------PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 231
                           P       TV  E  K+ +    ++H  +T+ E +  Q    A  
Sbjct: 684  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV-LQSPEFAIF 742

Query: 232  NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 291
             +  +   LK+ V+   +      +++    R  +  + Q        DSI     +   
Sbjct: 743  RKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI-----KQAS 797

Query: 292  QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI-----IAQGEQLIEKSEPLDAAI 346
            +  N      C + ++      +Q  I   +N+++Q+      A+    I+ + P +   
Sbjct: 798  EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 857

Query: 347  IEEELDELRRYCQEVFGRVERYHKKLIRLPLPD---DEHDLSDRELELEDSA-------A 396
            I+ +L    + C++   R+     ++ RL +      E       L+ +  A        
Sbjct: 858  IKSQL----KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
             SD+   ++   ++    P      +++  +R+     +T  S+  + +    DY++   
Sbjct: 914  FSDVQAREKELQTIFDTLPPMRYQETMS-AIRTWVQQSETKLSIPQLSVT---DYEIMEQ 969

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
                + +AL S  +E Q    +YL   V     M  ++P    +  ++  +   G    L
Sbjct: 970  RLGEL-QALQSSLQEQQSGL-YYLSTTV---KEMSKKAPSEISRKYQSEFEEIEGRWKKL 1024

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE------------ 564
             SQ+ +  + L++   ++++ +N I++      E+D   K     LG+            
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1084

Query: 565  --------CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 616
                       S++SV     K+K E E  P F +    ET+   +  +W+ +  Q  ++
Sbjct: 1085 LLVSDIQTIQPSLNSVNEGGQKIKNEAE--PEFAS--RLETELKELNTQWDHMCQQVYAR 1140

Query: 617  ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQIKKLK-ELQ 674
            +  +K  L+K      DL+ +  W+   EEE LE+    +   ++Q    ++K+ K E Q
Sbjct: 1141 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1200

Query: 675  KAVDHRKAIILSIN----LCSPEFTQADSKESRDL----QDRLSQMNGR----------W 716
            +     K +  S+N       P   +A  KE   L    Q   +++NG+          W
Sbjct: 1201 QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACW 1260

Query: 717  DRVCSLLEEWRGLLQDALMQCQ-------GFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 769
              + S LE+    L +   + +       G  E+S  +L  LEN+  R +E  P    + 
Sbjct: 1261 HELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE-VLDSLENL-MRHSEDNPNQIRIL 1318

Query: 770  AEILQDH--HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
            A+ L D     +L+  + E   S+ R    + +  Q L+        E ++ +H+I   L
Sbjct: 1319 AQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESL 1378

Query: 828  KLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNR 880
              + K+++ +I +      +    Q + S  ++ E+          G+    R
Sbjct: 1379 TFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1431



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 181/899 (20%), Positives = 348/899 (38%), Gaps = 108/899 (12%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+++   +    AS +E +L ++N +W H+   + AR + LK  L     L K++S +  
Sbjct: 1104 GQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHE 1163

Query: 62   WLAHIESE-LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+   E E L +   Y +   +E+Q+ + E +  + + ++    V  +      ++    
Sbjct: 1164 WMTQAEEEYLERDFEYKT--PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAP 1221

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A +A    ++  T N   +W  +C     +   +EE W  W + L    +   WL   
Sbjct: 1222 PVAQEALKKELETLTTNY--QW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEV 1277

Query: 181  E----RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            E     T   P  +  I     E L   E   R   +        N    R+  +  TD 
Sbjct: 1278 EFKLKTTENIPGGAEEI----SEVLDSLENLMRHSED--------NPNQIRILAQTLTDG 1325

Query: 237  ACSLKQMVHEG----NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
               + ++++E     N RW  L +      + L+  I   +E E +   I   LT +D Q
Sbjct: 1326 GV-MDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1384

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA--QGEQLIEKSEPLDAAIIEEE 350
            L       + D     ++ +  Q +++ +   +E++    QG++  ++        +  +
Sbjct: 1385 LA-AYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR--------VLSQ 1435

Query: 351  LDELRRYCQEV------FGRVERYHKKLIRLPLPDDEHDLSDRELE---LEDSAALSDLH 401
            +D  ++  Q+V      F +   + ++L    +  DE  +    LE   +E     S L+
Sbjct: 1436 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1495

Query: 402  WHDRSADSLLSPQPSSNLSLSLAQPL---RSERSGRDTPASVDSIPLEWDHDYDLSRDLE 458
                   SL   +    + +   + +   +   + ++    V ++ L ++       + +
Sbjct: 1496 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1555

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
              + + L    +  ++             +V+        ++LT+ +     G  S L+S
Sbjct: 1556 QQLEKCLKLSRKMRKE------------MNVLTEWLAATDMELTKRSA--VEGMPSNLDS 1601

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++   GKA   ++ +I++ +  ++S T  G  L T   G  + L E   S+ +   +   
Sbjct: 1602 EV-AWGKA---TQKEIEKQKVHLKSITEVGEALKT-VLGKKETLVEDKLSLLNSNWIAVT 1656

Query: 579  LKEEE--ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK---WQQFNSD 633
             + EE    L  +     T  Q    I +W ++QA  L  E   K+  QK    ++  ++
Sbjct: 1657 SRAEEWLNLLLEYQKHMETFDQNVDHITKW-IIQADTLLDESEKKKPQQKEDVLKRLKAE 1715

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR-KAIILSINLCSP 692
            LN I   +  T ++   L         + +E QI +L     A+ HR K    SI L   
Sbjct: 1716 LNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL--K 1773

Query: 693  EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE--MSHGLLLM 750
            E  Q +S    D+Q  L  +     +  +L EE     +D     +G  +  +  G  L 
Sbjct: 1774 ELEQFNS----DIQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQ 1827

Query: 751  LENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE---SQLRVASLQDMSCQLLVN 807
                D RK E + I             +QL+Q KH  L+   SQ R  +L+         
Sbjct: 1828 QRITDERKREEIKI------------KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1875

Query: 808  AEGTD---CLEAKEK--VHVIGNRLKLLLKEVSRHI-KELEKLLDVSSSQQDLSSWSSA 860
             +  D   CL+  EK    +   R +  +KE+ R + K+ E+L  V    + LS   +A
Sbjct: 1876 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA 1934



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 186/962 (19%), Positives = 396/962 (41%), Gaps = 138/962 (14%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            I  +L   N RW+ L +    R K L++++ + Q+ +K++  ++  L  I+ +LA  I  
Sbjct: 1332 INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA- 1390

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
            D  ++ ++ +   E Q++Q D+  H       ++L E+  H+          ++ Q+   
Sbjct: 1391 DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK-------EAAQRVLS 1434

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--S 189
             +D   + +  +SM+        +RL+QK     + FE  L+ S     E     P+  +
Sbjct: 1435 QIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVKMHLPALET 1482

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
              V   V + +L       + + E  +++E++ K  R++ ++ +T++   L + V     
Sbjct: 1483 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1542

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAK 307
             ++ L  +VT   ++L+  +    +     + +  WL   D++LT          ++ ++
Sbjct: 1543 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 1602

Query: 308  IKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD--------------AAIIEEE 350
            +   KA Q+EI      ++ I   GE L   + K E L                +  EE 
Sbjct: 1603 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEW 1662

Query: 351  LDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH- 401
            L+ L  Y +  E F + V+   K +I+     DE +   +  + ED      A L+D+  
Sbjct: 1663 LNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRP 1721

Query: 402  ----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDY 451
                  D++A+ + +     +    L +P  SE + R    S        SIPL+    +
Sbjct: 1722 KVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF 1778

Query: 452  D-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAY 498
            +     L   LE+ + + +  ++E+   D +    G V         L   +  E     
Sbjct: 1779 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1838

Query: 499  VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL 551
            +K+ +  ++        L SQ R+    +    +Q + Q +++++       K  + PE 
Sbjct: 1839 IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP 1898

Query: 552  --DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
              +   K   + L +    +++V+R    L E+  ++     +  T+ Q +    RW  +
Sbjct: 1899 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREI 1951

Query: 610  QAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQ 661
            +++ A  + L   Q      +       D+    +++  T   E+  + +  LE+   + 
Sbjct: 1952 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 2011

Query: 662  TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-----------DLQDRLS 710
              +L  K  ++L K  +  K I  S+   S       SK++             LQ+ LS
Sbjct: 2012 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2071

Query: 711  QMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSN 767
            Q++ +W++V  + ++ +G    ++ + + FH   ++ +  L   E   R+      I  N
Sbjct: 2072 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPEN 2127

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
             +    + + K+L      + + Q  V +L     +++  +  TD    +EK+  +  R 
Sbjct: 2128 WEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2184

Query: 828  KLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPR 885
            + + K++S   K LE+  ++ S  Q+DL+ +    +E D   S+    G+    ++K  +
Sbjct: 2185 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2244

Query: 886  GK 887
             K
Sbjct: 2245 VK 2246



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 60/290 (20%), Positives = 126/290 (43%), Gaps = 22/290 (7%)

Query: 11  ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
           E + +E++ ++  +N RW+ L      +   L   L+ +Q  ++ +  L  WL   E   
Sbjct: 406 EDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERT 463

Query: 71  AK----PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            K    P+  D    E+++R++ + + LQ D+E+    V S+ ++  V+    D  + D 
Sbjct: 464 RKMEEEPLGPDL---EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV----DESSGDH 516

Query: 127 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
              ++++  + L  RW NIC  + +R + +++    WQ+  ++   F  WL   E     
Sbjct: 517 ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE----- 571

Query: 187 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK-QMVH 245
             +   I+T   ++  +  +  +++      LE   KQ        + D   +LK + V 
Sbjct: 572 -DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK-KKQSMGKLYSLKQDLLSTLKNKSVT 629

Query: 246 EGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 294
           +  + W DN  +   +++++L+    Q  +  T     L   T M+   T
Sbjct: 630 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 679



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 71/324 (21%), Positives = 136/324 (41%), Gaps = 30/324 (9%)

Query: 492 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRSKTPTGP 549
           PE       L E+ + N     +ALE  +  L  A D  + Q  I     +++ +  T  
Sbjct: 317 PEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT-- 373

Query: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTETQTAGV 602
                ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++       
Sbjct: 374 -----HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS------- 421

Query: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
             RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L  D++ 
Sbjct: 422 --RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLED 477

Query: 663 IELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
           ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  RW  +C 
Sbjct: 478 LKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICR 537

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             E+   LLQD L++ Q   E        L   +   N+I         E+L    K L 
Sbjct: 538 WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQK-LA 596

Query: 782 QIKHELLESQLRVASLQDMSCQLL 805
            +K +L + +  +  L  +   LL
Sbjct: 597 VLKADLEKKKQSMGKLYSLKQDLL 620


>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
          Length = 2341

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 493  RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 552

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 553  EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 600

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 601  VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 655

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 656  YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 711

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 712  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 771

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 772  FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 830

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 831  KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 890

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 891  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 949

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 950  KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 996

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 997  LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 1056

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 1057 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 1115

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 1116 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1175

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 1176 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1235

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 1236 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 1289

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 1290 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 1341



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 1196 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 1255

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 1256 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 1307

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 1308 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 1363

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 1364 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1418

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 1419 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1478

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 1479 LKDDELS 1485



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 822  GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 881

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 882  WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 935

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 936  SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 995

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 996  LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 1055

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 1056 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 1114

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 1115 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 1174

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 1175 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 1234

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 1235 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 1287

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 1288 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 1322

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 1323 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 1497

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 1498 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1557

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 1558 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1617

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 1618 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1658



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 183/951 (19%), Positives = 362/951 (38%), Gaps = 124/951 (13%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTW 62
            SHE    E++ K  +  +  Q +L  I    KKL++  +  +   K       +   +  
Sbjct: 75   SHEISLEEMK-KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 133

Query: 63   LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
            L  ++  L   +   S   E +Q +LN    L + + +  + V  V+     ++      
Sbjct: 134  LDEVKMHLPA-LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT- 191

Query: 123  ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
                    + +    L   +  + A   ER+ ++E+  +L +K   + +   +WL +++ 
Sbjct: 192  ---ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDM 248

Query: 183  TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSA 237
                 S+   + +    E+   +A Q+++ +    L+ I +    L      +E   +  
Sbjct: 249  ELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDK 308

Query: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
             SL       N  W  +  R    L  L  +    E F+   D I  W+ + D  L   E
Sbjct: 309  LSLL------NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 362

Query: 298  HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 357
                   +  +K+LKA   E++    K++    Q   L+         ++E ++ EL   
Sbjct: 363  KKKPQQKEDVLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 419

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLS 412
               +  R++     +    L     D    L   E E++    L +  ++ D + D+  +
Sbjct: 420  FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGT 479

Query: 413  PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL-SRDLESAMSRALPSEDEE 471
             +       +L Q +  ER   +       +  + +   DL S+  + A+  +      +
Sbjct: 480  VKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 539

Query: 472  GQDDKDFYLRGAVGLSDVMIPE-SPEAYVKLTENAIKNTSGDHSALESQIRQLGK----- 525
             Q D        +      +PE   E  +K  +  ++    + +A+  Q   L +     
Sbjct: 540  RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 599

Query: 526  ALDDSRFQIQQTENIIRSK-----------------------TPTGPELDTSY--KGYMK 560
            A++ ++ Q+ +    I SK                       T   P L+ SY    Y+ 
Sbjct: 600  AVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP-LEISYVPSTYLT 658

Query: 561  LLGECSSSIDSVKRLEH----------KLKEEEESLPGFVN-----------LHSTET-- 597
             +   S ++  V++L +           L ++EESL    +           +HS +T  
Sbjct: 659  EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 718

Query: 598  -QTAGVIDRWELLQAQA-------------LSKELRMKQNLQKWQQFNSDLNSIWAWLGD 643
             Q+A  ++R +L +A +               ++ R  ++++KW++F+ D+     WL +
Sbjct: 719  LQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTE 778

Query: 644  TEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVDHRKAIILSINLCSPEFTQADSK-E 701
             E+ L + Q  E          + K  LKELQ  +  R+ ++ ++N    E  Q  SK +
Sbjct: 779  AEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 833

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 761
            +  LQ++L  +N RW  VC  L + +  L++       F    +  +L LE  D   +  
Sbjct: 834  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-- 891

Query: 762  VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA----EGTDCLEAK 817
            +P++   + + L++  +Q+  +  EL   Q  +  L +    +LV+A    E  D LE K
Sbjct: 892  IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 950

Query: 818  EKVH-----VIGNRLKLLLKEVSRHIKEL----EKLLDVSSSQQDLSSWSS 859
             K        +   L     E+   IK+L    +KL D+      L  W S
Sbjct: 951  LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 1001



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 180/941 (19%), Positives = 387/941 (41%), Gaps = 138/941 (14%)

Query: 38  RVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRD 97
           R K L++++ + Q+ +K++  ++  L  I+ +LA  I  D  ++ ++ +   E Q++Q D
Sbjct: 17  RQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA-DKVDAAQMPQ---EAQKIQSD 72

Query: 98  IEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE 157
           +  H       ++L E+  H+          ++ Q+    +D   + +  +SM+      
Sbjct: 73  LTSHE------ISLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMK------ 113

Query: 158 ETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--SSGVIYTVAKEELKKFEAFQRQ 210
             +RL+QK     + FE  L+ S     E     P+  +  V   V + +L       + 
Sbjct: 114 --FRLFQK----PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 167

Query: 211 VHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 270
           + E  +++E++ K  R++ ++ +T++   L + V      ++ L  +VT   ++L+  + 
Sbjct: 168 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 227

Query: 271 QREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKAFQQEISLNHNKIEQI 328
              +     + +  WL   D++LT          ++ +++   KA Q+EI      ++ I
Sbjct: 228 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 287

Query: 329 IAQGEQL---IEKSEPLD--------------AAIIEEELDELRRYCQ--EVFGR-VERY 368
              GE L   + K E L                +  EE L+ L  Y +  E F + V+  
Sbjct: 288 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 347

Query: 369 HKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH-----WHDRSADSLLSPQPSSN 418
            K +I+     DE +   +  + ED      A L+D+        D++A+ + +     +
Sbjct: 348 TKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN---RGD 403

Query: 419 LSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDYD-----LSRDLESAMSRALPS 467
               L +P  SE + R    S        SIPL+    ++     L   LE+ + + +  
Sbjct: 404 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNL 463

Query: 468 EDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
           ++E+   D +    G V         L   +  E     +K+ +  ++        L SQ
Sbjct: 464 KEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQ 523

Query: 520 IRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL--DTSYKGYMKLLGECSSSID 570
            R+    +    +Q + Q +++++       K  + PE   +   K   + L +    ++
Sbjct: 524 RRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELN 583

Query: 571 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ-ALSKELRMKQ----NLQ 625
           +V+R    L E+  ++     +  T+ Q +    RW  ++++ A  + L   Q      +
Sbjct: 584 AVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREIESKFAQFRRLNFAQIHTVREE 636

Query: 626 KWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQTIELQIKKLKELQKAVDHRKA 682
                  D+    +++  T   E+  + +  LE+   +   +L  K  ++L K  +  K 
Sbjct: 637 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 696

Query: 683 IILSINLCSPEFTQADSKESR-----------DLQDRLSQMNGRWDRVCSLLEEWRGLLQ 731
           I  S+   S       SK++             LQ+ LSQ++ +W++V  + ++ +G   
Sbjct: 697 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 756

Query: 732 DALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 788
            ++ + + FH   ++ +  L   E   R+      I  N +    + + K+L      + 
Sbjct: 757 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIG 809

Query: 789 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV- 847
           + Q  V +L     +++  +  TD    +EK+  +  R + + K++S   K LE+  ++ 
Sbjct: 810 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 869

Query: 848 SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPRGK 887
           S  Q+DL+ +    +E D   S+    G+    ++K  + K
Sbjct: 870 SEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910


>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
          Length = 2344

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 496  RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 555

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 556  EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 603

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 604  VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 658

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 659  YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 714

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 715  HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 775  FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 833

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 834  KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 893

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 894  SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 952

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 953  KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 999

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 1000 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 1059

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 1060 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 1118

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 1119 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 1178

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 1179 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 1238

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 1239 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 1292

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 1293 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 1344



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 1199 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 1258

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 1259 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 1310

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 1311 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 1366

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 1367 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 1421

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 1422 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 1481

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 1482 LKDDELS 1488



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 825  GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 884

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 885  WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 938

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 939  SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 998

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 999  LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 1058

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 1059 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 1117

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 1118 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 1177

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 1178 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 1237

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 1238 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 1290

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 1291 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 1325

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 1326 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 1443 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 1500

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 1501 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 1560

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 1561 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 1620

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 1621 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 1661



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 183/951 (19%), Positives = 362/951 (38%), Gaps = 124/951 (13%)

Query: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTW 62
            SHE    E++ K  +  +  Q +L  I    KKL++  +  +   K       +   +  
Sbjct: 78   SHEISLEEMK-KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136

Query: 63   LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 122
            L  ++  L   +   S   E +Q +LN    L + + +  + V  V+     ++      
Sbjct: 137  LDEVKMHLPA-LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT- 194

Query: 123  ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
                    + +    L   +  + A   ER+ ++E+  +L +K   + +   +WL +++ 
Sbjct: 195  ---ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDM 251

Query: 183  TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSA 237
                 S+   + +    E+   +A Q+++ +    L+ I +    L      +E   +  
Sbjct: 252  ELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDK 311

Query: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
             SL       N  W  +  R    L  L  +    E F+   D I  W+ + D  L   E
Sbjct: 312  LSLL------NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 365

Query: 298  HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 357
                   +  +K+LKA   E++    K++    Q   L+         ++E ++ EL   
Sbjct: 366  KKKPQQKEDVLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 422

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLS 412
               +  R++     +    L     D    L   E E++    L +  ++ D + D+  +
Sbjct: 423  FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGT 482

Query: 413  PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL-SRDLESAMSRALPSEDEE 471
             +       +L Q +  ER   +       +  + +   DL S+  + A+  +      +
Sbjct: 483  VKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 542

Query: 472  GQDDKDFYLRGAVGLSDVMIPE-SPEAYVKLTENAIKNTSGDHSALESQIRQLGK----- 525
             Q D        +      +PE   E  +K  +  ++    + +A+  Q   L +     
Sbjct: 543  RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 602

Query: 526  ALDDSRFQIQQTENIIRSK-----------------------TPTGPELDTSY--KGYMK 560
            A++ ++ Q+ +    I SK                       T   P L+ SY    Y+ 
Sbjct: 603  AVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP-LEISYVPSTYLT 661

Query: 561  LLGECSSSIDSVKRLEH----------KLKEEEESLPGFVN-----------LHSTET-- 597
             +   S ++  V++L +           L ++EESL    +           +HS +T  
Sbjct: 662  EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 721

Query: 598  -QTAGVIDRWELLQAQA-------------LSKELRMKQNLQKWQQFNSDLNSIWAWLGD 643
             Q+A  ++R +L +A +               ++ R  ++++KW++F+ D+     WL +
Sbjct: 722  LQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTE 781

Query: 644  TEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVDHRKAIILSINLCSPEFTQADSK-E 701
             E+ L + Q  E          + K  LKELQ  +  R+ ++ ++N    E  Q  SK +
Sbjct: 782  AEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 836

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 761
            +  LQ++L  +N RW  VC  L + +  L++       F    +  +L LE  D   +  
Sbjct: 837  ASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIAS-- 894

Query: 762  VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA----EGTDCLEAK 817
            +P++   + + L++  +Q+  +  EL   Q  +  L +    +LV+A    E  D LE K
Sbjct: 895  IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 953

Query: 818  EKVH-----VIGNRLKLLLKEVSRHIKEL----EKLLDVSSSQQDLSSWSS 859
             K        +   L     E+   IK+L    +KL D+      L  W S
Sbjct: 954  LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 1004



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 180/941 (19%), Positives = 387/941 (41%), Gaps = 138/941 (14%)

Query: 38  RVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRD 97
           R K L++++ + Q+ +K++  ++  L  I+ +LA  I  D  ++ ++ +   E Q++Q D
Sbjct: 20  RQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA-DKVDAAQMPQ---EAQKIQSD 75

Query: 98  IEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE 157
           +  H       ++L E+  H+          ++ Q+    +D   + +  +SM+      
Sbjct: 76  LTSHE------ISLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMK------ 116

Query: 158 ETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--SSGVIYTVAKEELKKFEAFQRQ 210
             +RL+QK     + FE  L+ S     E     P+  +  V   V + +L       + 
Sbjct: 117 --FRLFQK----PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 170

Query: 211 VHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 270
           + E  +++E++ K  R++ ++ +T++   L + V      ++ L  +VT   ++L+  + 
Sbjct: 171 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 230

Query: 271 QREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKAFQQEISLNHNKIEQI 328
              +     + +  WL   D++LT          ++ +++   KA Q+EI      ++ I
Sbjct: 231 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 290

Query: 329 IAQGEQL---IEKSEPLD--------------AAIIEEELDELRRYCQ--EVFGR-VERY 368
              GE L   + K E L                +  EE L+ L  Y +  E F + V+  
Sbjct: 291 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 350

Query: 369 HKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH-----WHDRSADSLLSPQPSSN 418
            K +I+     DE +   +  + ED      A L+D+        D++A+ + +     +
Sbjct: 351 TKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN---RGD 406

Query: 419 LSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDYD-----LSRDLESAMSRALPS 467
               L +P  SE + R    S        SIPL+    ++     L   LE+ + + +  
Sbjct: 407 HCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNL 466

Query: 468 EDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
           ++E+   D +    G V         L   +  E     +K+ +  ++        L SQ
Sbjct: 467 KEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQ 526

Query: 520 IRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL--DTSYKGYMKLLGECSSSID 570
            R+    +    +Q + Q +++++       K  + PE   +   K   + L +    ++
Sbjct: 527 RRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELN 586

Query: 571 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ-ALSKELRMKQ----NLQ 625
           +V+R    L E+  ++     +  T+ Q +    RW  ++++ A  + L   Q      +
Sbjct: 587 AVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREIESKFAQFRRLNFAQIHTVREE 639

Query: 626 KWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQTIELQIKKLKELQKAVDHRKA 682
                  D+    +++  T   E+  + +  LE+   +   +L  K  ++L K  +  K 
Sbjct: 640 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 699

Query: 683 IILSINLCSPEFTQADSKESR-----------DLQDRLSQMNGRWDRVCSLLEEWRGLLQ 731
           I  S+   S       SK++             LQ+ LSQ++ +W++V  + ++ +G   
Sbjct: 700 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 759

Query: 732 DALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 788
            ++ + + FH   ++ +  L   E   R+      I  N +    + + K+L      + 
Sbjct: 760 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIG 812

Query: 789 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV- 847
           + Q  V +L     +++  +  TD    +EK+  +  R + + K++S   K LE+  ++ 
Sbjct: 813 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 872

Query: 848 SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPRGK 887
           S  Q+DL+ +    +E D   S+    G+    ++K  + K
Sbjct: 873 SEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 913


>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
          Length = 3562

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 1714 RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 1773

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 1774 EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 1821

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 1822 VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 1876

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 1877 YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 1932

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 1933 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 1992

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 1993 FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2051

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 2052 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2111

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 2112 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 2170

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 2171 KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 2217

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 2218 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2277

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 2278 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 2336

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 2337 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 2396

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 2397 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 2456

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 2457 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 2510

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2511 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2562



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 154/870 (17%), Positives = 354/870 (40%), Gaps = 104/870 (11%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            + ++K +    + + + +  ++  RW+ L   +    +KL+E +  ++++  ++ +L+ W
Sbjct: 881  KEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKW 940

Query: 63   LAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +A ++  L +  P + D   SE ++++L + + L  DI+     + SV    + + ++  
Sbjct: 941  MAEVDVFLKEEWPALGD---SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-- 995

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A       ++   + L+ +W ++C     R+  ++           D S   +W+  +
Sbjct: 996  --AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQA 1053

Query: 181  -----ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
                 ER   + +   +   V + +  K EA Q++      +++L+ +    +  +    
Sbjct: 1054 EEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE-----AKVKLLTESVNSVIAQAPPV 1108

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
            +  +LK+ +      +  L  R+    + L+       E  +  +    WL E++ +L  
Sbjct: 1109 AQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKT 1168

Query: 296  IEHF--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             E+      ++   +  L+   +    N N+I +I+A   Q +     +D  +I EEL+ 
Sbjct: 1169 TENIPGGAEEISEVLDSLENLMRHSEDNPNQI-RILA---QTLTDGGVMD-ELINEELET 1223

Query: 354  LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 413
                 +E+       H++ +R     ++   S +E E         L + D+   + ++ 
Sbjct: 1224 FNSRWREL-------HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD 1276

Query: 414  QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 473
            +  +      AQ ++S+ +  +       I LE    ++  ++   A  R L   D    
Sbjct: 1277 KVDAAQMPQEAQKIQSDLTSHE-------ISLEEMKKHNQGKE---AAQRVLSQID---- 1322

Query: 474  DDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSA-LESQIRQLGKALDDSRF 532
                                   A  KL + ++K       A  E ++++    LD+ + 
Sbjct: 1323 ----------------------VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKM 1360

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
             +   E     +     +L+     Y K L E  S ++ V +   ++ +++++     N 
Sbjct: 1361 HLPALETKSVEQEVVQSQLNHCVNLY-KSLSEVKSEVEMVIKTGRQIVQKKQT----ENP 1415

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +   +   +  L A+   ++ ++++ L+  ++   ++N +  WL  T+ EL +  
Sbjct: 1416 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1475

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             +E       ++ ++   K  QK ++ +K  + SI            K+   ++D+LS +
Sbjct: 1476 AVEGMP--SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL 1533

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD-AE 771
            N  W  V S  EEW  LL +     + F           +N+D     I+  D+ LD +E
Sbjct: 1534 NSNWIAVTSRAEEWLNLLLEYQKHMETFD----------QNVDHITKWIIQADTLLDESE 1583

Query: 772  ILQDHHKQ--LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC--------LEAKEKVH 821
              +   K+  L ++K EL + + +V S +D +  L+ N  G  C         E   +  
Sbjct: 1584 KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN-RGDHCRKLVEPQISELNHRFA 1642

Query: 822  VIGNRLK-----LLLKEVSRHIKELEKLLD 846
             I +R+K     + LKE+ +   +++KLL+
Sbjct: 1643 AISHRIKTGKASIPLKELEQFNSDIQKLLE 1672



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 2417 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 2476

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 2477 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2528

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 2529 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2584

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 2585 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 2639

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 2640 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2699

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 2700 LKDDELS 2706



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 163/904 (18%), Positives = 354/904 (39%), Gaps = 161/904 (17%)

Query: 14   ASEIEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMSSLRTWLAHIE 67
            A  I+    ++N RW     L++ R+  L+    ++A    +QQL++  ++   WL    
Sbjct: 675  ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 734

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
            +  ++P    S   +  + ++N    LQ  IE+        L +  + L +        +
Sbjct: 735  TTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALKEKGQGPMFLD 785

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
             D +   T +  + + ++ A   E +   +    +  ++ +  S    W++ SE   + P
Sbjct: 786  ADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIP 842

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEG 247
              S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +   +    E 
Sbjct: 843  QLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI 902

Query: 248  NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI-EHFSECDVQA 306
              RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L        + ++  
Sbjct: 903  EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 962

Query: 307  K-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR----RYCQEV 361
            K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL       CQ+V
Sbjct: 963  KQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV 1022

Query: 362  FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSLLSPQPSSNLS 420
            + R E     L             ++ + L+    LS++H W  ++ +  L         
Sbjct: 1023 YARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEYL--------- 1058

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
                                     E D +Y    +L+ A+     +++E  Q +    L
Sbjct: 1059 -------------------------ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKL 1093

Query: 481  RGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE----------SQI 520
                 ++ V+    P + EA  K  E    N        +G    LE          S +
Sbjct: 1094 L-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYL 1152

Query: 521  RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLK 580
             +  K L++  F+++ TENI     P G E             E S  +DS   LE+ ++
Sbjct: 1153 EKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLDS---LENLMR 1191

Query: 581  EEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKELRMKQNLQKWQ 628
              E++ P  + + +      GV+D            RW  L  +A+ ++  ++Q++Q  Q
Sbjct: 1192 HSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ 1250

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            +              TE+ L  +Q      D Q       K+   Q   + +K   +  +
Sbjct: 1251 E--------------TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSD 1293

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
            L S E +  + K+    ++          RV S ++  +  LQD  M+ + F + ++   
Sbjct: 1294 LTSHEISLEEMKKHNQGKEAAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 1346

Query: 749  LMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
             + E+   +D  K  +  +++ +++ E++Q      + +   L E +  V  +     Q+
Sbjct: 1347 RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 1406

Query: 805  LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSA 860
            +   +  +  E  E+V  +      L  +V+   ++LEK L +S   +     L+ W +A
Sbjct: 1407 VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 1466

Query: 861  DELD 864
             +++
Sbjct: 1467 TDME 1470



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 2043 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2102

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 2103 WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 2156

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 2157 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 2216

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 2217 LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 2276

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 2277 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2335

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 2336 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2395

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 2396 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 2455

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 2456 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 2508

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 2509 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 2543

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 2544 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2600

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 2601 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2660

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 2661 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 2718

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 2719 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2778

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 2779 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2838

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2839 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 177/953 (18%), Positives = 360/953 (37%), Gaps = 111/953 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++S +   + +E +L  + DRW ++      R   L++ L+  Q+L +       WL+  
Sbjct: 396  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 455

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            E  + K       +  E+   L +   L+ D+EK    +  + +L + LL       +  
Sbjct: 456  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLL-------STL 508

Query: 127  ECDSIQQATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            +  S+ Q T     N  R W N+     +   +I +     Q  L   +  E     + R
Sbjct: 509  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568

Query: 183  TAAF-----------PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 231
                           P       TV  E  K+ +    ++H  +T+ E +  Q    A  
Sbjct: 569  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV-LQSPEFAIF 627

Query: 232  NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 291
             +  +   LK+ V+   +      +++    R  +  + Q        DSI     +   
Sbjct: 628  RKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI-----KQAS 682

Query: 292  QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI-----IAQGEQLIEKSEPLDAAI 346
            +  N      C + ++      +Q  I   +N+++Q+      A+    I+ + P +   
Sbjct: 683  EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 742

Query: 347  IEEELDELRRYCQEVFGRVERYHKKLIRLPLPD---DEHDLSDRELELEDSA-------A 396
            I+ +L    + C++   R+     ++ RL +      E       L+ +  A        
Sbjct: 743  IKSQL----KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
             SD+   ++   ++    P      +++  +R+     +T  S+  + +    DY++   
Sbjct: 799  FSDVQAREKELQTIFDTLPPMRYQETMS-AIRTWVQQSETKLSIPQLSVT---DYEIMEQ 854

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
                + +AL S  +E Q    +YL   V     M  ++P    +  ++  +   G    L
Sbjct: 855  RLGEL-QALQSSLQEQQSGL-YYLSTTV---KEMSKKAPSEISRKYQSEFEEIEGRWKKL 909

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE------------ 564
             SQ+ +  + L++   ++++ +N I++      E+D   K     LG+            
Sbjct: 910  SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 969

Query: 565  --------CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 616
                       S++SV     K+K E E  P F +    ET+   +  +W+ +  Q  ++
Sbjct: 970  LLVSDIQTIQPSLNSVNEGGQKIKNEAE--PEFAS--RLETELKELNTQWDHMCQQVYAR 1025

Query: 617  ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQIKKLK-ELQ 674
            +  +K  L+K      DL+ +  W+   EEE LE+    +   ++Q    ++K+ K E Q
Sbjct: 1026 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1085

Query: 675  KAVDHRKAIILSIN----LCSPEFTQADSKESRDL----QDRLSQMNGR----------W 716
            +     K +  S+N       P   +A  KE   L    Q   +++NG+          W
Sbjct: 1086 QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACW 1145

Query: 717  DRVCSLLEEWRGLLQDALMQCQ-------GFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 769
              + S LE+    L +   + +       G  E+S  +L  LEN+  R +E  P    + 
Sbjct: 1146 HELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE-VLDSLENL-MRHSEDNPNQIRIL 1203

Query: 770  AEILQDH--HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
            A+ L D     +L+  + E   S+ R    + +  Q L+        E ++ +H+I   L
Sbjct: 1204 AQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESL 1263

Query: 828  KLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNR 880
              + K+++ +I +      +    Q + S  ++ E+          G+    R
Sbjct: 1264 TFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1316



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 181/899 (20%), Positives = 348/899 (38%), Gaps = 108/899 (12%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+++   +    AS +E +L ++N +W H+   + AR + LK  L     L K++S +  
Sbjct: 989  GQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHE 1048

Query: 62   WLAHIESE-LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+   E E L +   Y +   +E+Q+ + E +  + + ++    V  +      ++    
Sbjct: 1049 WMTQAEEEYLERDFEYKT--PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAP 1106

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A +A    ++  T N   +W  +C     +   +EE W  W + L    +   WL   
Sbjct: 1107 PVAQEALKKELETLTTNY--QW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEV 1162

Query: 181  E----RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            E     T   P  +  I     E L   E   R   +        N    R+  +  TD 
Sbjct: 1163 EFKLKTTENIPGGAEEI----SEVLDSLENLMRHSED--------NPNQIRILAQTLTDG 1210

Query: 237  ACSLKQMVHEG----NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
               + ++++E     N RW  L +      + L+  I   +E E +   I   LT +D Q
Sbjct: 1211 GV-MDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1269

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA--QGEQLIEKSEPLDAAIIEEE 350
            L       + D     ++ +  Q +++ +   +E++    QG++  ++        +  +
Sbjct: 1270 LA-AYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR--------VLSQ 1320

Query: 351  LDELRRYCQEV------FGRVERYHKKLIRLPLPDDEHDLSDRELE---LEDSAALSDLH 401
            +D  ++  Q+V      F +   + ++L    +  DE  +    LE   +E     S L+
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380

Query: 402  WHDRSADSLLSPQPSSNLSLSLAQPL---RSERSGRDTPASVDSIPLEWDHDYDLSRDLE 458
                   SL   +    + +   + +   +   + ++    V ++ L ++       + +
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
              + + L    +  ++             +V+        ++LT+ +     G  S L+S
Sbjct: 1441 QQLEKCLKLSRKMRKE------------MNVLTEWLAATDMELTKRSA--VEGMPSNLDS 1486

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++   GKA   ++ +I++ +  ++S T  G  L T   G  + L E   S+ +   +   
Sbjct: 1487 EV-AWGKA---TQKEIEKQKVHLKSITEVGEALKT-VLGKKETLVEDKLSLLNSNWIAVT 1541

Query: 579  LKEEE--ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK---WQQFNSD 633
             + EE    L  +     T  Q    I +W ++QA  L  E   K+  QK    ++  ++
Sbjct: 1542 SRAEEWLNLLLEYQKHMETFDQNVDHITKW-IIQADTLLDESEKKKPQQKEDVLKRLKAE 1600

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR-KAIILSINLCSP 692
            LN I   +  T ++   L         + +E QI +L     A+ HR K    SI L   
Sbjct: 1601 LNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL--K 1658

Query: 693  EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE--MSHGLLLM 750
            E  Q +S    D+Q  L  +     +  +L EE     +D     +G  +  +  G  L 
Sbjct: 1659 ELEQFNS----DIQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQ 1712

Query: 751  LENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE---SQLRVASLQDMSCQLLVN 807
                D RK E + I             +QL+Q KH  L+   SQ R  +L+         
Sbjct: 1713 QRITDERKREEIKI------------KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1760

Query: 808  AEGTD---CLEAKEK--VHVIGNRLKLLLKEVSRHI-KELEKLLDVSSSQQDLSSWSSA 860
             +  D   CL+  EK    +   R +  +KE+ R + K+ E+L  V    + LS   +A
Sbjct: 1761 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA 1819



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 186/962 (19%), Positives = 396/962 (41%), Gaps = 138/962 (14%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            I  +L   N RW+ L +    R K L++++ + Q+ +K++  ++  L  I+ +LA  I  
Sbjct: 1217 INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA- 1275

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
            D  ++ ++ +   E Q++Q D+  H       ++L E+  H+          ++ Q+   
Sbjct: 1276 DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK-------EAAQRVLS 1319

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--S 189
             +D   + +  +SM+        +RL+QK     + FE  L+ S     E     P+  +
Sbjct: 1320 QIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVKMHLPALET 1367

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
              V   V + +L       + + E  +++E++ K  R++ ++ +T++   L + V     
Sbjct: 1368 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1427

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAK 307
             ++ L  +VT   ++L+  +    +     + +  WL   D++LT          ++ ++
Sbjct: 1428 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 1487

Query: 308  IKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD--------------AAIIEEE 350
            +   KA Q+EI      ++ I   GE L   + K E L                +  EE 
Sbjct: 1488 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEW 1547

Query: 351  LDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH- 401
            L+ L  Y +  E F + V+   K +I+     DE +   +  + ED      A L+D+  
Sbjct: 1548 LNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRP 1606

Query: 402  ----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDY 451
                  D++A+ + +     +    L +P  SE + R    S        SIPL+    +
Sbjct: 1607 KVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF 1663

Query: 452  D-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAY 498
            +     L   LE+ + + +  ++E+   D +    G V         L   +  E     
Sbjct: 1664 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1723

Query: 499  VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL 551
            +K+ +  ++        L SQ R+    +    +Q + Q +++++       K  + PE 
Sbjct: 1724 IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP 1783

Query: 552  --DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
              +   K   + L +    +++V+R    L E+  ++     +  T+ Q +    RW  +
Sbjct: 1784 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREI 1836

Query: 610  QAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQ 661
            +++ A  + L   Q      +       D+    +++  T   E+  + +  LE+   + 
Sbjct: 1837 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 1896

Query: 662  TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-----------DLQDRLS 710
              +L  K  ++L K  +  K I  S+   S       SK++             LQ+ LS
Sbjct: 1897 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 1956

Query: 711  QMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSN 767
            Q++ +W++V  + ++ +G    ++ + + FH   ++ +  L   E   R+      I  N
Sbjct: 1957 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPEN 2012

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
             +    + + K+L      + + Q  V +L     +++  +  TD    +EK+  +  R 
Sbjct: 2013 WEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2069

Query: 828  KLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPR 885
            + + K++S   K LE+  ++ S  Q+DL+ +    +E D   S+    G+    ++K  +
Sbjct: 2070 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2129

Query: 886  GK 887
             K
Sbjct: 2130 VK 2131



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 60/290 (20%), Positives = 126/290 (43%), Gaps = 22/290 (7%)

Query: 11  ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
           E + +E++ ++  +N RW+ L      +   L   L+ +Q  ++ +  L  WL   E   
Sbjct: 291 EDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERT 348

Query: 71  AK----PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            K    P+  D    E+++R++ + + LQ D+E+    V S+ ++  V+    D  + D 
Sbjct: 349 RKMEEEPLGPDL---EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV----DESSGDH 401

Query: 127 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
              ++++  + L  RW NIC  + +R + +++    WQ+  ++   F  WL   E     
Sbjct: 402 ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE----- 456

Query: 187 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK-QMVH 245
             +   I+T   ++  +  +  +++      LE   KQ        + D   +LK + V 
Sbjct: 457 -DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK-KKQSMGKLYSLKQDLLSTLKNKSVT 514

Query: 246 EGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 294
           +  + W DN  +   +++++L+    Q  +  T     L   T M+   T
Sbjct: 515 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 564



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 71/324 (21%), Positives = 136/324 (41%), Gaps = 30/324 (9%)

Query: 492 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRSKTPTGP 549
           PE       L E+ + N     +ALE  +  L  A D  + Q  I     +++ +  T  
Sbjct: 202 PEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT-- 258

Query: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTETQTAGV 602
                ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++       
Sbjct: 259 -----HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS------- 306

Query: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
             RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L  D++ 
Sbjct: 307 --RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLED 362

Query: 663 IELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
           ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  RW  +C 
Sbjct: 363 LKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICR 422

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             E+   LLQD L++ Q   E        L   +   N+I         E+L    K L 
Sbjct: 423 WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQK-LA 481

Query: 782 QIKHELLESQLRVASLQDMSCQLL 805
            +K +L + +  +  L  +   LL
Sbjct: 482 VLKADLEKKKQSMGKLYSLKQDLL 505


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 1833 RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 1892

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 1893 EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 1940

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 1941 VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 1995

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 1996 YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 2051

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 2052 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 2111

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 2112 FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2170

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 2171 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2230

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 2231 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 2289

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 2290 KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 2336

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 2337 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2396

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 2455

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 2456 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 2515

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 2516 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 2575

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 2576 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 2629

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2630 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 154/870 (17%), Positives = 354/870 (40%), Gaps = 104/870 (11%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            + ++K +    + + + +  ++  RW+ L   +    +KL+E +  ++++  ++ +L+ W
Sbjct: 1000 KEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKW 1059

Query: 63   LAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +A ++  L +  P + D   SE ++++L + + L  DI+     + SV    + + ++  
Sbjct: 1060 MAEVDVFLKEEWPALGD---SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-- 1114

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A       ++   + L+ +W ++C     R+  ++           D S   +W+  +
Sbjct: 1115 --AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQA 1172

Query: 181  -----ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
                 ER   + +   +   V + +  K EA Q++      +++L+ +    +  +    
Sbjct: 1173 EEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE-----AKVKLLTESVNSVIAQAPPV 1227

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
            +  +LK+ +      +  L  R+    + L+       E  +  +    WL E++ +L  
Sbjct: 1228 AQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKT 1287

Query: 296  IEHF--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             E+      ++   +  L+   +    N N+I +I+A   Q +     +D  +I EEL+ 
Sbjct: 1288 TENIPGGAEEISEVLDSLENLMRHSEDNPNQI-RILA---QTLTDGGVMD-ELINEELET 1342

Query: 354  LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 413
                 +E+       H++ +R     ++   S +E E         L + D+   + ++ 
Sbjct: 1343 FNSRWREL-------HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD 1395

Query: 414  QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 473
            +  +      AQ ++S+ +  +       I LE    ++  ++   A  R L   D    
Sbjct: 1396 KVDAAQMPQEAQKIQSDLTSHE-------ISLEEMKKHNQGKE---AAQRVLSQID---- 1441

Query: 474  DDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSA-LESQIRQLGKALDDSRF 532
                                   A  KL + ++K       A  E ++++    LD+ + 
Sbjct: 1442 ----------------------VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKM 1479

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
             +   E     +     +L+     Y K L E  S ++ V +   ++ +++++     N 
Sbjct: 1480 HLPALETKSVEQEVVQSQLNHCVNLY-KSLSEVKSEVEMVIKTGRQIVQKKQT----ENP 1534

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +   +   +  L A+   ++ ++++ L+  ++   ++N +  WL  T+ EL +  
Sbjct: 1535 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1594

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             +E       ++ ++   K  QK ++ +K  + SI            K+   ++D+LS +
Sbjct: 1595 AVEGMP--SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL 1652

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD-AE 771
            N  W  V S  EEW  LL +     + F           +N+D     I+  D+ LD +E
Sbjct: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFD----------QNVDHITKWIIQADTLLDESE 1702

Query: 772  ILQDHHKQ--LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC--------LEAKEKVH 821
              +   K+  L ++K EL + + +V S +D +  L+ N  G  C         E   +  
Sbjct: 1703 KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN-RGDHCRKLVEPQISELNHRFA 1761

Query: 822  VIGNRLK-----LLLKEVSRHIKELEKLLD 846
             I +R+K     + LKE+ +   +++KLL+
Sbjct: 1762 AISHRIKTGKASIPLKELEQFNSDIQKLLE 1791



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 2536 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 2595

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 2596 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2647

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 2648 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2703

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 2704 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 2758

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 2759 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2818

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 2819 LKDDELS 2825



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 163/904 (18%), Positives = 354/904 (39%), Gaps = 161/904 (17%)

Query: 14   ASEIEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMSSLRTWLAHIE 67
            A  I+    ++N RW     L++ R+  L+    ++A    +QQL++  ++   WL    
Sbjct: 794  ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 853

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
            +  ++P    S   +  + ++N    LQ  IE+        L +  + L +        +
Sbjct: 854  TTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALKEKGQGPMFLD 904

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
             D +   T +  + + ++ A   E +   +    +  ++ +  S    W++ SE   + P
Sbjct: 905  ADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIP 961

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEG 247
              S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +   +    E 
Sbjct: 962  QLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI 1021

Query: 248  NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI-EHFSECDVQA 306
              RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L        + ++  
Sbjct: 1022 EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1081

Query: 307  K-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR----RYCQEV 361
            K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL       CQ+V
Sbjct: 1082 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV 1141

Query: 362  FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSLLSPQPSSNLS 420
            + R E     L             ++ + L+    LS++H W  ++ +  L         
Sbjct: 1142 YARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEYL--------- 1177

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
                                     E D +Y    +L+ A+     +++E  Q +    L
Sbjct: 1178 -------------------------ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKL 1212

Query: 481  RGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE----------SQI 520
                 ++ V+    P + EA  K  E    N        +G    LE          S +
Sbjct: 1213 L-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYL 1271

Query: 521  RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLK 580
             +  K L++  F+++ TENI     P G E             E S  +DS   LE+ ++
Sbjct: 1272 EKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLDS---LENLMR 1310

Query: 581  EEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKELRMKQNLQKWQ 628
              E++ P  + + +      GV+D            RW  L  +A+ ++  ++Q++Q  Q
Sbjct: 1311 HSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ 1369

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            +              TE+ L  +Q      D Q       K+   Q   + +K   +  +
Sbjct: 1370 E--------------TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSD 1412

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
            L S E +  + K+    ++          RV S ++  +  LQD  M+ + F + ++   
Sbjct: 1413 LTSHEISLEEMKKHNQGKEAAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 1465

Query: 749  LMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
             + E+   +D  K  +  +++ +++ E++Q      + +   L E +  V  +     Q+
Sbjct: 1466 RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 1525

Query: 805  LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSA 860
            +   +  +  E  E+V  +      L  +V+   ++LEK L +S   +     L+ W +A
Sbjct: 1526 VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 1585

Query: 861  DELD 864
             +++
Sbjct: 1586 TDME 1589



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 2222 WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 2275

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 2276 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 2335

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 2336 LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 2395

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 2396 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2454

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 2455 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2514

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 2515 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 2574

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 2575 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 2627

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 2628 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 2662

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 2663 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2719

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 2720 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2779

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 2780 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 2837

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 2838 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2897

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2957

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2958 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 177/953 (18%), Positives = 360/953 (37%), Gaps = 111/953 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++S +   + +E +L  + DRW ++      R   L++ L+  Q+L +       WL+  
Sbjct: 515  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 574

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            E  + K       +  E+   L +   L+ D+EK    +  + +L + LL       +  
Sbjct: 575  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLL-------STL 627

Query: 127  ECDSIQQATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            +  S+ Q T     N  R W N+     +   +I +     Q  L   +  E     + R
Sbjct: 628  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687

Query: 183  TAAF-----------PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 231
                           P       TV  E  K+ +    ++H  +T+ E +  Q    A  
Sbjct: 688  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV-LQSPEFAIF 746

Query: 232  NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 291
             +  +   LK+ V+   +      +++    R  +  + Q        DSI     +   
Sbjct: 747  RKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI-----KQAS 801

Query: 292  QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI-----IAQGEQLIEKSEPLDAAI 346
            +  N      C + ++      +Q  I   +N+++Q+      A+    I+ + P +   
Sbjct: 802  EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861

Query: 347  IEEELDELRRYCQEVFGRVERYHKKLIRLPLPD---DEHDLSDRELELEDSA-------A 396
            I+ +L    + C++   R+     ++ RL +      E       L+ +  A        
Sbjct: 862  IKSQL----KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
             SD+   ++   ++    P      +++  +R+     +T  S+  + +    DY++   
Sbjct: 918  FSDVQAREKELQTIFDTLPPMRYQETMS-AIRTWVQQSETKLSIPQLSVT---DYEIMEQ 973

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
                + +AL S  +E Q    +YL   V     M  ++P    +  ++  +   G    L
Sbjct: 974  RLGEL-QALQSSLQEQQSGL-YYLSTTV---KEMSKKAPSEISRKYQSEFEEIEGRWKKL 1028

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE------------ 564
             SQ+ +  + L++   ++++ +N I++      E+D   K     LG+            
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088

Query: 565  --------CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 616
                       S++SV     K+K E E  P F +    ET+   +  +W+ +  Q  ++
Sbjct: 1089 LLVSDIQTIQPSLNSVNEGGQKIKNEAE--PEFAS--RLETELKELNTQWDHMCQQVYAR 1144

Query: 617  ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQIKKLK-ELQ 674
            +  +K  L+K      DL+ +  W+   EEE LE+    +   ++Q    ++K+ K E Q
Sbjct: 1145 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1204

Query: 675  KAVDHRKAIILSIN----LCSPEFTQADSKESRDL----QDRLSQMNGR----------W 716
            +     K +  S+N       P   +A  KE   L    Q   +++NG+          W
Sbjct: 1205 QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACW 1264

Query: 717  DRVCSLLEEWRGLLQDALMQCQ-------GFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 769
              + S LE+    L +   + +       G  E+S  +L  LEN+  R +E  P    + 
Sbjct: 1265 HELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE-VLDSLENL-MRHSEDNPNQIRIL 1322

Query: 770  AEILQDH--HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
            A+ L D     +L+  + E   S+ R    + +  Q L+        E ++ +H+I   L
Sbjct: 1323 AQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESL 1382

Query: 828  KLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNR 880
              + K+++ +I +      +    Q + S  ++ E+          G+    R
Sbjct: 1383 TFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1435



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 181/899 (20%), Positives = 348/899 (38%), Gaps = 108/899 (12%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+++   +    AS +E +L ++N +W H+   + AR + LK  L     L K++S +  
Sbjct: 1108 GQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHE 1167

Query: 62   WLAHIESE-LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+   E E L +   Y +   +E+Q+ + E +  + + ++    V  +      ++    
Sbjct: 1168 WMTQAEEEYLERDFEYKT--PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAP 1225

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A +A    ++  T N   +W  +C     +   +EE W  W + L    +   WL   
Sbjct: 1226 PVAQEALKKELETLTTNY--QW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEV 1281

Query: 181  E----RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            E     T   P  +  I     E L   E   R   +        N    R+  +  TD 
Sbjct: 1282 EFKLKTTENIPGGAEEI----SEVLDSLENLMRHSED--------NPNQIRILAQTLTDG 1329

Query: 237  ACSLKQMVHEG----NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
               + ++++E     N RW  L +      + L+  I   +E E +   I   LT +D Q
Sbjct: 1330 GV-MDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA--QGEQLIEKSEPLDAAIIEEE 350
            L       + D     ++ +  Q +++ +   +E++    QG++  ++        +  +
Sbjct: 1389 LA-AYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR--------VLSQ 1439

Query: 351  LDELRRYCQEV------FGRVERYHKKLIRLPLPDDEHDLSDRELE---LEDSAALSDLH 401
            +D  ++  Q+V      F +   + ++L    +  DE  +    LE   +E     S L+
Sbjct: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499

Query: 402  WHDRSADSLLSPQPSSNLSLSLAQPL---RSERSGRDTPASVDSIPLEWDHDYDLSRDLE 458
                   SL   +    + +   + +   +   + ++    V ++ L ++       + +
Sbjct: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
              + + L    +  ++             +V+        ++LT+ +     G  S L+S
Sbjct: 1560 QQLEKCLKLSRKMRKE------------MNVLTEWLAATDMELTKRSA--VEGMPSNLDS 1605

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++   GKA   ++ +I++ +  ++S T  G  L T   G  + L E   S+ +   +   
Sbjct: 1606 EV-AWGKA---TQKEIEKQKVHLKSITEVGEALKT-VLGKKETLVEDKLSLLNSNWIAVT 1660

Query: 579  LKEEE--ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK---WQQFNSD 633
             + EE    L  +     T  Q    I +W ++QA  L  E   K+  QK    ++  ++
Sbjct: 1661 SRAEEWLNLLLEYQKHMETFDQNVDHITKW-IIQADTLLDESEKKKPQQKEDVLKRLKAE 1719

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR-KAIILSINLCSP 692
            LN I   +  T ++   L         + +E QI +L     A+ HR K    SI L   
Sbjct: 1720 LNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL--K 1777

Query: 693  EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE--MSHGLLLM 750
            E  Q +S    D+Q  L  +     +  +L EE     +D     +G  +  +  G  L 
Sbjct: 1778 ELEQFNS----DIQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQ 1831

Query: 751  LENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE---SQLRVASLQDMSCQLLVN 807
                D RK E + I             +QL+Q KH  L+   SQ R  +L+         
Sbjct: 1832 QRITDERKREEIKI------------KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1879

Query: 808  AEGTD---CLEAKEK--VHVIGNRLKLLLKEVSRHI-KELEKLLDVSSSQQDLSSWSSA 860
             +  D   CL+  EK    +   R +  +KE+ R + K+ E+L  V    + LS   +A
Sbjct: 1880 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA 1938



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 186/962 (19%), Positives = 396/962 (41%), Gaps = 138/962 (14%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            I  +L   N RW+ L +    R K L++++ + Q+ +K++  ++  L  I+ +LA  I  
Sbjct: 1336 INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA- 1394

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
            D  ++ ++ +   E Q++Q D+  H       ++L E+  H+          ++ Q+   
Sbjct: 1395 DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK-------EAAQRVLS 1438

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--S 189
             +D   + +  +SM+        +RL+QK     + FE  L+ S     E     P+  +
Sbjct: 1439 QIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVKMHLPALET 1486

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
              V   V + +L       + + E  +++E++ K  R++ ++ +T++   L + V     
Sbjct: 1487 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1546

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAK 307
             ++ L  +VT   ++L+  +    +     + +  WL   D++LT          ++ ++
Sbjct: 1547 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 1606

Query: 308  IKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD--------------AAIIEEE 350
            +   KA Q+EI      ++ I   GE L   + K E L                +  EE 
Sbjct: 1607 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEW 1666

Query: 351  LDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH- 401
            L+ L  Y +  E F + V+   K +I+     DE +   +  + ED      A L+D+  
Sbjct: 1667 LNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRP 1725

Query: 402  ----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDY 451
                  D++A+ + +     +    L +P  SE + R    S        SIPL+    +
Sbjct: 1726 KVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF 1782

Query: 452  D-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAY 498
            +     L   LE+ + + +  ++E+   D +    G V         L   +  E     
Sbjct: 1783 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1842

Query: 499  VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL 551
            +K+ +  ++        L SQ R+    +    +Q + Q +++++       K  + PE 
Sbjct: 1843 IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP 1902

Query: 552  --DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
              +   K   + L +    +++V+R    L E+  ++     +  T+ Q +    RW  +
Sbjct: 1903 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREI 1955

Query: 610  QAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQ 661
            +++ A  + L   Q      +       D+    +++  T   E+  + +  LE+   + 
Sbjct: 1956 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 2015

Query: 662  TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-----------DLQDRLS 710
              +L  K  ++L K  +  K I  S+   S       SK++             LQ+ LS
Sbjct: 2016 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075

Query: 711  QMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSN 767
            Q++ +W++V  + ++ +G    ++ + + FH   ++ +  L   E   R+      I  N
Sbjct: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPEN 2131

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
             +    + + K+L      + + Q  V +L     +++  +  TD    +EK+  +  R 
Sbjct: 2132 WEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2188

Query: 828  KLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPR 885
            + + K++S   K LE+  ++ S  Q+DL+ +    +E D   S+    G+    ++K  +
Sbjct: 2189 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2248

Query: 886  GK 887
             K
Sbjct: 2249 VK 2250



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 60/290 (20%), Positives = 126/290 (43%), Gaps = 22/290 (7%)

Query: 11  ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
           E + +E++ ++  +N RW+ L      +   L   L+ +Q  ++ +  L  WL   E   
Sbjct: 410 EDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERT 467

Query: 71  AK----PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            K    P+  D    E+++R++ + + LQ D+E+    V S+ ++  V+    D  + D 
Sbjct: 468 RKMEEEPLGPDL---EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV----DESSGDH 520

Query: 127 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
              ++++  + L  RW NIC  + +R + +++    WQ+  ++   F  WL   E     
Sbjct: 521 ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE----- 575

Query: 187 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK-QMVH 245
             +   I+T   ++  +  +  +++      LE   KQ        + D   +LK + V 
Sbjct: 576 -DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK-KKQSMGKLYSLKQDLLSTLKNKSVT 633

Query: 246 EGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 294
           +  + W DN  +   +++++L+    Q  +  T     L   T M+   T
Sbjct: 634 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 683



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 71/324 (21%), Positives = 136/324 (41%), Gaps = 30/324 (9%)

Query: 492 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRSKTPTGP 549
           PE       L E+ + N     +ALE  +  L  A D  + Q  I     +++ +  T  
Sbjct: 321 PEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT-- 377

Query: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTETQTAGV 602
                ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++       
Sbjct: 378 -----HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS------- 425

Query: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
             RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L  D++ 
Sbjct: 426 --RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLED 481

Query: 663 IELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
           ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  RW  +C 
Sbjct: 482 LKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICR 541

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             E+   LLQD L++ Q   E        L   +   N+I         E+L    K L 
Sbjct: 542 WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQK-LA 600

Query: 782 QIKHELLESQLRVASLQDMSCQLL 805
            +K +L + +  +  L  +   LL
Sbjct: 601 VLKADLEKKKQSMGKLYSLKQDLL 624


>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
          Length = 3562

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 1714 RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 1773

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 1774 EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 1821

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 1822 VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 1876

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 1877 YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 1932

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 1933 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 1992

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 1993 FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2051

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 2052 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2111

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 2112 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 2170

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 2171 KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 2217

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 2218 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2277

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 2278 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 2336

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 2337 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 2396

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 2397 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 2456

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 2457 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 2510

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2511 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2562



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 154/870 (17%), Positives = 354/870 (40%), Gaps = 104/870 (11%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            + ++K +    + + + +  ++  RW+ L   +    +KL+E +  ++++  ++ +L+ W
Sbjct: 881  KEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKW 940

Query: 63   LAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +A ++  L +  P + D   SE ++++L + + L  DI+     + SV    + + ++  
Sbjct: 941  MAEVDVFLKEEWPALGD---SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-- 995

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A       ++   + L+ +W ++C     R+  ++           D S   +W+  +
Sbjct: 996  --AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQA 1053

Query: 181  -----ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
                 ER   + +   +   V + +  K EA Q++      +++L+ +    +  +    
Sbjct: 1054 EEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE-----AKVKLLTESVNSVIAQAPPV 1108

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
            +  +LK+ +      +  L  R+    + L+       E  +  +    WL E++ +L  
Sbjct: 1109 AQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKT 1168

Query: 296  IEHF--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             E+      ++   +  L+   +    N N+I +I+A   Q +     +D  +I EEL+ 
Sbjct: 1169 TENIPGGAEEISEVLDSLENLMRHSEDNPNQI-RILA---QTLTDGGVMD-ELINEELET 1223

Query: 354  LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 413
                 +E+       H++ +R     ++   S +E E         L + D+   + ++ 
Sbjct: 1224 FNSRWREL-------HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD 1276

Query: 414  QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 473
            +  +      AQ ++S+ +  +       I LE    ++  ++   A  R L   D    
Sbjct: 1277 KVDAAQMPQEAQKIQSDLTSHE-------ISLEEMKKHNQGKE---AAQRVLSQID---- 1322

Query: 474  DDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSA-LESQIRQLGKALDDSRF 532
                                   A  KL + ++K       A  E ++++    LD+ + 
Sbjct: 1323 ----------------------VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKM 1360

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
             +   E     +     +L+     Y K L E  S ++ V +   ++ +++++     N 
Sbjct: 1361 HLPALETKSVEQEVVQSQLNHCVNLY-KSLSEVKSEVEMVIKTGRQIVQKKQT----ENP 1415

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +   +   +  L A+   ++ ++++ L+  ++   ++N +  WL  T+ EL +  
Sbjct: 1416 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1475

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             +E       ++ ++   K  QK ++ +K  + SI            K+   ++D+LS +
Sbjct: 1476 AVEGMP--SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL 1533

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD-AE 771
            N  W  V S  EEW  LL +     + F           +N+D     I+  D+ LD +E
Sbjct: 1534 NSNWIAVTSRAEEWLNLLLEYQKHMETFD----------QNVDHITKWIIQADTLLDESE 1583

Query: 772  ILQDHHKQ--LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC--------LEAKEKVH 821
              +   K+  L ++K EL + + +V S +D +  L+ N  G  C         E   +  
Sbjct: 1584 KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN-RGDHCRKLVEPQISELNHRFA 1642

Query: 822  VIGNRLK-----LLLKEVSRHIKELEKLLD 846
             I +R+K     + LKE+ +   +++KLL+
Sbjct: 1643 AISHRIKTGKASIPLKELEQFNSDIQKLLE 1672



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 2417 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 2476

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 2477 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2528

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 2529 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2584

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 2585 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 2639

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 2640 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2699

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 2700 LKDDELS 2706



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 163/904 (18%), Positives = 354/904 (39%), Gaps = 161/904 (17%)

Query: 14   ASEIEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMSSLRTWLAHIE 67
            A  I+    ++N RW     L++ R+  L+    ++A    +QQL++  ++   WL    
Sbjct: 675  ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 734

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
            +  ++P    S   +  + ++N    LQ  IE+        L +  + L +        +
Sbjct: 735  TTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALKEKGQGPMFLD 785

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
             D +   T +  + + ++ A   E +   +    +  ++ +  S    W++ SE   + P
Sbjct: 786  ADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIP 842

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEG 247
              S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +   +    E 
Sbjct: 843  QLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI 902

Query: 248  NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI-EHFSECDVQA 306
              RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L        + ++  
Sbjct: 903  EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 962

Query: 307  K-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR----RYCQEV 361
            K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL       CQ+V
Sbjct: 963  KQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV 1022

Query: 362  FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSLLSPQPSSNLS 420
            + R E     L             ++ + L+    LS++H W  ++ +  L         
Sbjct: 1023 YARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEYL--------- 1058

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
                                     E D +Y    +L+ A+     +++E  Q +    L
Sbjct: 1059 -------------------------ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKL 1093

Query: 481  RGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE----------SQI 520
                 ++ V+    P + EA  K  E    N        +G    LE          S +
Sbjct: 1094 L-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYL 1152

Query: 521  RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLK 580
             +  K L++  F+++ TENI     P G E             E S  +DS   LE+ ++
Sbjct: 1153 EKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLDS---LENLMR 1191

Query: 581  EEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKELRMKQNLQKWQ 628
              E++ P  + + +      GV+D            RW  L  +A+ ++  ++Q++Q  Q
Sbjct: 1192 HSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ 1250

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            +              TE+ L  +Q      D Q       K+   Q   + +K   +  +
Sbjct: 1251 E--------------TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSD 1293

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
            L S E +  + K+    ++          RV S ++  +  LQD  M+ + F + ++   
Sbjct: 1294 LTSHEISLEEMKKHNQGKEAAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 1346

Query: 749  LMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
             + E+   +D  K  +  +++ +++ E++Q      + +   L E +  V  +     Q+
Sbjct: 1347 RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 1406

Query: 805  LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSA 860
            +   +  +  E  E+V  +      L  +V+   ++LEK L +S   +     L+ W +A
Sbjct: 1407 VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 1466

Query: 861  DELD 864
             +++
Sbjct: 1467 TDME 1470



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 2043 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2102

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 2103 WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 2156

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 2157 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 2216

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 2217 LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 2276

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 2277 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2335

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 2336 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2395

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 2396 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 2455

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 2456 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 2508

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 2509 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 2543

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 2544 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2600

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 2601 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2660

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 2661 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 2718

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 2719 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2778

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 2779 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2838

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2839 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 177/953 (18%), Positives = 360/953 (37%), Gaps = 111/953 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++S +   + +E +L  + DRW ++      R   L++ L+  Q+L +       WL+  
Sbjct: 396  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 455

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            E  + K       +  E+   L +   L+ D+EK    +  + +L + LL       +  
Sbjct: 456  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLL-------STL 508

Query: 127  ECDSIQQATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            +  S+ Q T     N  R W N+     +   +I +     Q  L   +  E     + R
Sbjct: 509  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568

Query: 183  TAAF-----------PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 231
                           P       TV  E  K+ +    ++H  +T+ E +  Q    A  
Sbjct: 569  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV-LQSPEFAIF 627

Query: 232  NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 291
             +  +   LK+ V+   +      +++    R  +  + Q        DSI     +   
Sbjct: 628  RKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI-----KQAS 682

Query: 292  QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI-----IAQGEQLIEKSEPLDAAI 346
            +  N      C + ++      +Q  I   +N+++Q+      A+    I+ + P +   
Sbjct: 683  EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 742

Query: 347  IEEELDELRRYCQEVFGRVERYHKKLIRLPLPD---DEHDLSDRELELEDSA-------A 396
            I+ +L    + C++   R+     ++ RL +      E       L+ +  A        
Sbjct: 743  IKSQL----KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
             SD+   ++   ++    P      +++  +R+     +T  S+  + +    DY++   
Sbjct: 799  FSDVQAREKELQTIFDTLPPMRYQETMS-AIRTWVQQSETKLSIPQLSVT---DYEIMEQ 854

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
                + +AL S  +E Q    +YL   V     M  ++P    +  ++  +   G    L
Sbjct: 855  RLGEL-QALQSSLQEQQSGL-YYLSTTV---KEMSKKAPSEISRKYQSEFEEIEGRWKKL 909

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE------------ 564
             SQ+ +  + L++   ++++ +N I++      E+D   K     LG+            
Sbjct: 910  SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 969

Query: 565  --------CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 616
                       S++SV     K+K E E  P F +    ET+   +  +W+ +  Q  ++
Sbjct: 970  LLVSDIQTIQPSLNSVNEGGQKIKNEAE--PEFAS--RLETELKELNTQWDHMCQQVYAR 1025

Query: 617  ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQIKKLK-ELQ 674
            +  +K  L+K      DL+ +  W+   EEE LE+    +   ++Q    ++K+ K E Q
Sbjct: 1026 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1085

Query: 675  KAVDHRKAIILSIN----LCSPEFTQADSKESRDL----QDRLSQMNGR----------W 716
            +     K +  S+N       P   +A  KE   L    Q   +++NG+          W
Sbjct: 1086 QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACW 1145

Query: 717  DRVCSLLEEWRGLLQDALMQCQ-------GFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 769
              + S LE+    L +   + +       G  E+S  +L  LEN+  R +E  P    + 
Sbjct: 1146 HELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE-VLDSLENL-MRHSEDNPNQIRIL 1203

Query: 770  AEILQDH--HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
            A+ L D     +L+  + E   S+ R    + +  Q L+        E ++ +H+I   L
Sbjct: 1204 AQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESL 1263

Query: 828  KLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNR 880
              + K+++ +I +      +    Q + S  ++ E+          G+    R
Sbjct: 1264 TFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1316



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 181/899 (20%), Positives = 348/899 (38%), Gaps = 108/899 (12%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+++   +    AS +E +L ++N +W H+   + AR + LK  L     L K++S +  
Sbjct: 989  GQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHE 1048

Query: 62   WLAHIESE-LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+   E E L +   Y +   +E+Q+ + E +  + + ++    V  +      ++    
Sbjct: 1049 WMTQAEEEYLERDFEYKT--PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAP 1106

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A +A    ++  T N   +W  +C     +   +EE W  W + L    +   WL   
Sbjct: 1107 PVAQEALKKELETLTTNY--QW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEV 1162

Query: 181  E----RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            E     T   P  +  I     E L   E   R   +        N    R+  +  TD 
Sbjct: 1163 EFKLKTTENIPGGAEEI----SEVLDSLENLMRHSED--------NPNQIRILAQTLTDG 1210

Query: 237  ACSLKQMVHEG----NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
               + ++++E     N RW  L +      + L+  I   +E E +   I   LT +D Q
Sbjct: 1211 GV-MDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1269

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA--QGEQLIEKSEPLDAAIIEEE 350
            L       + D     ++ +  Q +++ +   +E++    QG++  ++        +  +
Sbjct: 1270 LA-AYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR--------VLSQ 1320

Query: 351  LDELRRYCQEV------FGRVERYHKKLIRLPLPDDEHDLSDRELE---LEDSAALSDLH 401
            +D  ++  Q+V      F +   + ++L    +  DE  +    LE   +E     S L+
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380

Query: 402  WHDRSADSLLSPQPSSNLSLSLAQPL---RSERSGRDTPASVDSIPLEWDHDYDLSRDLE 458
                   SL   +    + +   + +   +   + ++    V ++ L ++       + +
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
              + + L    +  ++             +V+        ++LT+ +     G  S L+S
Sbjct: 1441 QQLEKCLKLSRKMRKE------------MNVLTEWLAATDMELTKRSA--VEGMPSNLDS 1486

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++   GKA   ++ +I++ +  ++S T  G  L T   G  + L E   S+ +   +   
Sbjct: 1487 EV-AWGKA---TQKEIEKQKVHLKSITEVGEALKT-VLGKKETLVEDKLSLLNSNWIAVT 1541

Query: 579  LKEEE--ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK---WQQFNSD 633
             + EE    L  +     T  Q    I +W ++QA  L  E   K+  QK    ++  ++
Sbjct: 1542 SRAEEWLNLLLEYQKHMETFDQNVDHITKW-IIQADTLLDESEKKKPQQKEDVLKRLKAE 1600

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR-KAIILSINLCSP 692
            LN I   +  T ++   L         + +E QI +L     A+ HR K    SI L   
Sbjct: 1601 LNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL--K 1658

Query: 693  EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE--MSHGLLLM 750
            E  Q +S    D+Q  L  +     +  +L EE     +D     +G  +  +  G  L 
Sbjct: 1659 ELEQFNS----DIQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQ 1712

Query: 751  LENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE---SQLRVASLQDMSCQLLVN 807
                D RK E + I             +QL+Q KH  L+   SQ R  +L+         
Sbjct: 1713 QRITDERKREEIKI------------KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1760

Query: 808  AEGTD---CLEAKEK--VHVIGNRLKLLLKEVSRHI-KELEKLLDVSSSQQDLSSWSSA 860
             +  D   CL+  EK    +   R +  +KE+ R + K+ E+L  V    + LS   +A
Sbjct: 1761 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA 1819



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 186/962 (19%), Positives = 396/962 (41%), Gaps = 138/962 (14%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            I  +L   N RW+ L +    R K L++++ + Q+ +K++  ++  L  I+ +LA  I  
Sbjct: 1217 INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA- 1275

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
            D  ++ ++ +   E Q++Q D+  H       ++L E+  H+          ++ Q+   
Sbjct: 1276 DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK-------EAAQRVLS 1319

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--S 189
             +D   + +  +SM+        +RL+QK     + FE  L+ S     E     P+  +
Sbjct: 1320 QIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVKMHLPALET 1367

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
              V   V + +L       + + E  +++E++ K  R++ ++ +T++   L + V     
Sbjct: 1368 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1427

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAK 307
             ++ L  +VT   ++L+  +    +     + +  WL   D++LT          ++ ++
Sbjct: 1428 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 1487

Query: 308  IKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD--------------AAIIEEE 350
            +   KA Q+EI      ++ I   GE L   + K E L                +  EE 
Sbjct: 1488 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEW 1547

Query: 351  LDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH- 401
            L+ L  Y +  E F + V+   K +I+     DE +   +  + ED      A L+D+  
Sbjct: 1548 LNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRP 1606

Query: 402  ----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDY 451
                  D++A+ + +     +    L +P  SE + R    S        SIPL+    +
Sbjct: 1607 KVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF 1663

Query: 452  D-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAY 498
            +     L   LE+ + + +  ++E+   D +    G V         L   +  E     
Sbjct: 1664 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1723

Query: 499  VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL 551
            +K+ +  ++        L SQ R+    +    +Q + Q +++++       K  + PE 
Sbjct: 1724 IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP 1783

Query: 552  --DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
              +   K   + L +    +++V+R    L E+  ++     +  T+ Q +    RW  +
Sbjct: 1784 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREI 1836

Query: 610  QAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQ 661
            +++ A  + L   Q      +       D+    +++  T   E+  + +  LE+   + 
Sbjct: 1837 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 1896

Query: 662  TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-----------DLQDRLS 710
              +L  K  ++L K  +  K I  S+   S       SK++             LQ+ LS
Sbjct: 1897 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 1956

Query: 711  QMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSN 767
            Q++ +W++V  + ++ +G    ++ + + FH   ++ +  L   E   R+      I  N
Sbjct: 1957 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPEN 2012

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
             +    + + K+L      + + Q  V +L     +++  +  TD    +EK+  +  R 
Sbjct: 2013 WEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2069

Query: 828  KLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPR 885
            + + K++S   K LE+  ++ S  Q+DL+ +    +E D   S+    G+    ++K  +
Sbjct: 2070 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2129

Query: 886  GK 887
             K
Sbjct: 2130 VK 2131



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 60/290 (20%), Positives = 126/290 (43%), Gaps = 22/290 (7%)

Query: 11  ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
           E + +E++ ++  +N RW+ L      +   L   L+ +Q  ++ +  L  WL   E   
Sbjct: 291 EDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERT 348

Query: 71  AK----PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            K    P+  D    E+++R++ + + LQ D+E+    V S+ ++  V+    D  + D 
Sbjct: 349 RKMEEEPLGPDL---EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV----DESSGDH 401

Query: 127 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
              ++++  + L  RW NIC  + +R + +++    WQ+  ++   F  WL   E     
Sbjct: 402 ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE----- 456

Query: 187 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK-QMVH 245
             +   I+T   ++  +  +  +++      LE   KQ        + D   +LK + V 
Sbjct: 457 -DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK-KKQSMGKLYSLKQDLLSTLKNKSVT 514

Query: 246 EGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 294
           +  + W DN  +   +++++L+    Q  +  T     L   T M+   T
Sbjct: 515 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 564



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 71/324 (21%), Positives = 136/324 (41%), Gaps = 30/324 (9%)

Query: 492 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRSKTPTGP 549
           PE       L E+ + N     +ALE  +  L  A D  + Q  I     +++ +  T  
Sbjct: 202 PEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT-- 258

Query: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTETQTAGV 602
                ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++       
Sbjct: 259 -----HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS------- 306

Query: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
             RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L  D++ 
Sbjct: 307 --RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLED 362

Query: 663 IELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
           ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  RW  +C 
Sbjct: 363 LKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICR 422

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             E+   LLQD L++ Q   E        L   +   N+I         E+L    K L 
Sbjct: 423 WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQK-LA 481

Query: 782 QIKHELLESQLRVASLQDMSCQLL 805
            +K +L + +  +  L  +   LL
Sbjct: 482 VLKADLEKKKQSMGKLYSLKQDLL 505


>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
          Length = 3685

 Score =  110 bits (275), Expect = 6e-24
 Identities = 186/896 (20%), Positives = 352/896 (39%), Gaps = 103/896 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L  I
Sbjct: 1837 RITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDI 1896

Query: 67   ESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 125
            E +LA  P   D    +EI R+L +++E    + + + G++             D  A  
Sbjct: 1897 EKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAAMA 1944

Query: 126  AECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK------------ 165
             E   IQ     L +RWR I    +  RRL         EET  +  +            
Sbjct: 1945 VEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST 1999

Query: 166  FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELI 221
            +L + +     L   E+    P      +    E+L K E   + + + L Q    +++I
Sbjct: 2000 YLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRIDII 2055

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 281
            + +     +         L++ + + + +W+ + K       R    + +   F      
Sbjct: 2056 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 2115

Query: 282  ILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEKSE 340
               WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++S 
Sbjct: 2116 FNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2174

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAALS 398
              DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  ++
Sbjct: 2175 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2234

Query: 399  DLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR 455
             +         L        L    L L Q +  + +    P  V S P+  +    L  
Sbjct: 2235 SIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKLEN 2293

Query: 456  DLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 509
             L+        +SRALP  +++G+ +      G +           E  ++  E  + + 
Sbjct: 2294 KLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLNHL 2340

Query: 510  SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYM 559
                S + +Q+    +   +  F +Q+TE  +++K P   E+            + +   
Sbjct: 2341 LLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK 2400

Query: 560  KLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
            + L + SS   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L
Sbjct: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-L 2459

Query: 619  RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKA 676
             M  +L       +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + 
Sbjct: 2460 EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD 2519

Query: 677  VDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLL 730
            ++ R+  +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L
Sbjct: 2520 LEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEML 2579

Query: 731  QDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES 790
            +D+    +   E    L      ++  K     +D+      +Q    +  Q+  +L + 
Sbjct: 2580 KDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQW 2633

Query: 791  QLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 846
            Q  V    D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2634 QTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2685



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 154/870 (17%), Positives = 354/870 (40%), Gaps = 104/870 (11%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            + ++K +    + + + +  ++  RW+ L   +    +KL+E +  ++++  ++ +L+ W
Sbjct: 1004 KEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKW 1063

Query: 63   LAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +A ++  L +  P + D   SE ++++L + + L  DI+     + SV    + + ++  
Sbjct: 1064 MAEVDVFLKEEWPALGD---SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-- 1118

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A       ++   + L+ +W ++C     R+  ++           D S   +W+  +
Sbjct: 1119 --AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQA 1176

Query: 181  -----ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
                 ER   + +   +   V + +  K EA Q++      +++L+ +    +  +    
Sbjct: 1177 EEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE-----AKVKLLTESVNSVIAQAPPV 1231

Query: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN 295
            +  +LK+ +      +  L  R+    + L+       E  +  +    WL E++ +L  
Sbjct: 1232 AQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKT 1291

Query: 296  IEHF--SECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 353
             E+      ++   +  L+   +    N N+I +I+A   Q +     +D  +I EEL+ 
Sbjct: 1292 TENIPGGAEEISEVLDSLENLMRHSEDNPNQI-RILA---QTLTDGGVMD-ELINEELET 1346

Query: 354  LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 413
                 +E+       H++ +R     ++   S +E E         L + D+   + ++ 
Sbjct: 1347 FNSRWREL-------HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD 1399

Query: 414  QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 473
            +  +      AQ ++S+ +  +       I LE    ++  ++   A  R L   D    
Sbjct: 1400 KVDAAQMPQEAQKIQSDLTSHE-------ISLEEMKKHNQGKE---AAQRVLSQID---- 1445

Query: 474  DDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSA-LESQIRQLGKALDDSRF 532
                                   A  KL + ++K       A  E ++++    LD+ + 
Sbjct: 1446 ----------------------VAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKM 1483

Query: 533  QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592
             +   E     +     +L+     Y K L E  S ++ V +   ++ +++++     N 
Sbjct: 1484 HLPALETKSVEQEVVQSQLNHCVNLY-KSLSEVKSEVEMVIKTGRQIVQKKQT----ENP 1538

Query: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
               + +   +   +  L A+   ++ ++++ L+  ++   ++N +  WL  T+ EL +  
Sbjct: 1539 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1598

Query: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
             +E       ++ ++   K  QK ++ +K  + SI            K+   ++D+LS +
Sbjct: 1599 AVEGMP--SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL 1656

Query: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD-AE 771
            N  W  V S  EEW  LL +     + F           +N+D     I+  D+ LD +E
Sbjct: 1657 NSNWIAVTSRAEEWLNLLLEYQKHMETFD----------QNVDHITKWIIQADTLLDESE 1706

Query: 772  ILQDHHKQ--LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC--------LEAKEKVH 821
              +   K+  L ++K EL + + +V S +D +  L+ N  G  C         E   +  
Sbjct: 1707 KKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN-RGDHCRKLVEPQISELNHRFA 1765

Query: 822  VIGNRLK-----LLLKEVSRHIKELEKLLD 846
             I +R+K     + LKE+ +   +++KLL+
Sbjct: 1766 AISHRIKTGKASIPLKELEQFNSDIQKLLE 1795



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
            K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 2540 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 2599

Query: 60   RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
            R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 2600 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2651

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
             A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 2652 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2707

Query: 180  SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
            +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 2708 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 2762

Query: 229  ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
             R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 2763 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2822

Query: 288  EMDLQLT 294
              D +L+
Sbjct: 2823 LKDDELS 2829



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 163/904 (18%), Positives = 354/904 (39%), Gaps = 161/904 (17%)

Query: 14   ASEIEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMSSLRTWLAHIE 67
            A  I+    ++N RW     L++ R+  L+    ++A    +QQL++  ++   WL    
Sbjct: 798  ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP 857

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
            +  ++P    S   +  + ++N    LQ  IE+        L +  + L +        +
Sbjct: 858  TTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALKEKGQGPMFLD 908

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
             D +   T +  + + ++ A   E +   +    +  ++ +  S    W++ SE   + P
Sbjct: 909  ADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIP 965

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEG 247
              S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +   +    E 
Sbjct: 966  QLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI 1025

Query: 248  NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI-EHFSECDVQA 306
              RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L        + ++  
Sbjct: 1026 EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1085

Query: 307  K-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR----RYCQEV 361
            K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL       CQ+V
Sbjct: 1086 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV 1145

Query: 362  FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSLLSPQPSSNLS 420
            + R E     L             ++ + L+    LS++H W  ++ +  L         
Sbjct: 1146 YARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEYL--------- 1181

Query: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
                                     E D +Y    +L+ A+     +++E  Q +    L
Sbjct: 1182 -------------------------ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKL 1216

Query: 481  RGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE----------SQI 520
                 ++ V+    P + EA  K  E    N        +G    LE          S +
Sbjct: 1217 L-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYL 1275

Query: 521  RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLK 580
             +  K L++  F+++ TENI     P G E             E S  +DS   LE+ ++
Sbjct: 1276 EKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLDS---LENLMR 1314

Query: 581  EEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKELRMKQNLQKWQ 628
              E++ P  + + +      GV+D            RW  L  +A+ ++  ++Q++Q  Q
Sbjct: 1315 HSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ 1373

Query: 629  QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 688
            +              TE+ L  +Q      D Q       K+   Q   + +K   +  +
Sbjct: 1374 E--------------TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSD 1416

Query: 689  LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 748
            L S E +  + K+    ++          RV S ++  +  LQD  M+ + F + ++   
Sbjct: 1417 LTSHEISLEEMKKHNQGKEAAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQ 1469

Query: 749  LMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
             + E+   +D  K  +  +++ +++ E++Q      + +   L E +  V  +     Q+
Sbjct: 1470 RLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 1529

Query: 805  LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSA 860
            +   +  +  E  E+V  +      L  +V+   ++LEK L +S   +     L+ W +A
Sbjct: 1530 VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA 1589

Query: 861  DELD 864
             +++
Sbjct: 1590 TDME 1593



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 158/882 (17%), Positives = 345/882 (39%), Gaps = 124/882 (14%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L+E    + +  ++++    
Sbjct: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDC 119
            WL   ++  + P+  +    ++++ KL + + L  ++     G+   LN     VL+   
Sbjct: 2226 WLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ-GILKQLNETGGPVLV--- 2279

Query: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE----ETWRLWQKFLDDYSRFED 175
             A  +  E D ++   +  + +W  +     E++ +IE    +  +L +K  D   +   
Sbjct: 2280 SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH 2339

Query: 176  ---WLK----------SSERTAAFPSSSGVIYTVAKE---------------ELKKFEAF 207
               WL              +   F      I   AK+               E    +  
Sbjct: 2340 LLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPV 2399

Query: 208  QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV----TSILR 263
            +R++ +  ++ + +N+  + L R  + D A  L  +     Q    + + V    T+I +
Sbjct: 2400 KRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2458

Query: 264  -----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316
                  L   +    +F  A   +  WL+ +D  ++   +      D+   I + KA  Q
Sbjct: 2459 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2518

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRL 375
            ++     ++E++I   + L  K+   +A  II + ++ ++    EV   ++   ++L  +
Sbjct: 2519 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM 2578

Query: 376  PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 435
                 +   +  E E     A + L        ++ + Q     +  LA+ LR       
Sbjct: 2579 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR------- 2631

Query: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495
                      +W  + D++ DL   + R     D    D +  +          MI E+ 
Sbjct: 2632 ----------QWQTNVDVANDLALKLLR-----DYSADDTRKVH----------MITENI 2666

Query: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGP 549
             A  +      K  S   +ALE   R L +  LD  +F     + + T N+++  T    
Sbjct: 2667 NASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 2723

Query: 550  ELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI 603
             L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   + 
Sbjct: 2724 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 2783

Query: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
             +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   +
Sbjct: 2784 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAV 2841

Query: 664  ELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE---------------------S 702
            + Q    +  ++ +  ++ +I+S       F      E                     +
Sbjct: 2842 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2901

Query: 703  RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K    
Sbjct: 2902 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2961

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 804
            P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2962 PV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 177/953 (18%), Positives = 360/953 (37%), Gaps = 111/953 (11%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++S +   + +E +L  + DRW ++      R   L++ L+  Q+L +       WL+  
Sbjct: 519  ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 578

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            E  + K       +  E+   L +   L+ D+EK    +  + +L + LL       +  
Sbjct: 579  EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLL-------STL 631

Query: 127  ECDSIQQATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 182
            +  S+ Q T     N  R W N+     +   +I +     Q  L   +  E     + R
Sbjct: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691

Query: 183  TAAF-----------PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 231
                           P       TV  E  K+ +    ++H  +T+ E +  Q    A  
Sbjct: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAV-LQSPEFAIF 750

Query: 232  NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 291
             +  +   LK+ V+   +      +++    R  +  + Q        DSI     +   
Sbjct: 751  RKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSI-----KQAS 805

Query: 292  QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQI-----IAQGEQLIEKSEPLDAAI 346
            +  N      C + ++      +Q  I   +N+++Q+      A+    I+ + P +   
Sbjct: 806  EQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865

Query: 347  IEEELDELRRYCQEVFGRVERYHKKLIRLPLPD---DEHDLSDRELELEDSA-------A 396
            I+ +L    + C++   R+     ++ RL +      E       L+ +  A        
Sbjct: 866  IKSQL----KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921

Query: 397  LSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRD 456
             SD+   ++   ++    P      +++  +R+     +T  S+  + +    DY++   
Sbjct: 922  FSDVQAREKELQTIFDTLPPMRYQETMS-AIRTWVQQSETKLSIPQLSVT---DYEIMEQ 977

Query: 457  LESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSAL 516
                + +AL S  +E Q    +YL   V     M  ++P    +  ++  +   G    L
Sbjct: 978  RLGEL-QALQSSLQEQQSGL-YYLSTTV---KEMSKKAPSEISRKYQSEFEEIEGRWKKL 1032

Query: 517  ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE------------ 564
             SQ+ +  + L++   ++++ +N I++      E+D   K     LG+            
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092

Query: 565  --------CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 616
                       S++SV     K+K E E  P F +    ET+   +  +W+ +  Q  ++
Sbjct: 1093 LLVSDIQTIQPSLNSVNEGGQKIKNEAE--PEFAS--RLETELKELNTQWDHMCQQVYAR 1148

Query: 617  ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQIKKLK-ELQ 674
            +  +K  L+K      DL+ +  W+   EEE LE+    +   ++Q    ++K+ K E Q
Sbjct: 1149 KEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQ 1208

Query: 675  KAVDHRKAIILSIN----LCSPEFTQADSKESRDL----QDRLSQMNGR----------W 716
            +     K +  S+N       P   +A  KE   L    Q   +++NG+          W
Sbjct: 1209 QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACW 1268

Query: 717  DRVCSLLEEWRGLLQDALMQCQ-------GFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 769
              + S LE+    L +   + +       G  E+S  +L  LEN+  R +E  P    + 
Sbjct: 1269 HELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE-VLDSLENL-MRHSEDNPNQIRIL 1326

Query: 770  AEILQDH--HKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
            A+ L D     +L+  + E   S+ R    + +  Q L+        E ++ +H+I   L
Sbjct: 1327 AQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESL 1386

Query: 828  KLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNR 880
              + K+++ +I +      +    Q + S  ++ E+          G+    R
Sbjct: 1387 TFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1439



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 181/899 (20%), Positives = 348/899 (38%), Gaps = 108/899 (12%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+++   +    AS +E +L ++N +W H+   + AR + LK  L     L K++S +  
Sbjct: 1112 GQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHE 1171

Query: 62   WLAHIESE-LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+   E E L +   Y +   +E+Q+ + E +  + + ++    V  +      ++    
Sbjct: 1172 WMTQAEEEYLERDFEYKT--PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAP 1229

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
              A +A    ++  T N   +W  +C     +   +EE W  W + L    +   WL   
Sbjct: 1230 PVAQEALKKELETLTTNY--QW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEV 1285

Query: 181  E----RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
            E     T   P  +  I     E L   E   R   +        N    R+  +  TD 
Sbjct: 1286 EFKLKTTENIPGGAEEI----SEVLDSLENLMRHSED--------NPNQIRILAQTLTDG 1333

Query: 237  ACSLKQMVHEG----NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
               + ++++E     N RW  L +      + L+  I   +E E +   I   LT +D Q
Sbjct: 1334 GV-MDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392

Query: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA--QGEQLIEKSEPLDAAIIEEE 350
            L       + D     ++ +  Q +++ +   +E++    QG++  ++        +  +
Sbjct: 1393 LA-AYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR--------VLSQ 1443

Query: 351  LDELRRYCQEV------FGRVERYHKKLIRLPLPDDEHDLSDRELE---LEDSAALSDLH 401
            +D  ++  Q+V      F +   + ++L    +  DE  +    LE   +E     S L+
Sbjct: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503

Query: 402  WHDRSADSLLSPQPSSNLSLSLAQPL---RSERSGRDTPASVDSIPLEWDHDYDLSRDLE 458
                   SL   +    + +   + +   +   + ++    V ++ L ++       + +
Sbjct: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563

Query: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518
              + + L    +  ++             +V+        ++LT+ +     G  S L+S
Sbjct: 1564 QQLEKCLKLSRKMRKE------------MNVLTEWLAATDMELTKRSA--VEGMPSNLDS 1609

Query: 519  QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 578
            ++   GKA   ++ +I++ +  ++S T  G  L T   G  + L E   S+ +   +   
Sbjct: 1610 EV-AWGKA---TQKEIEKQKVHLKSITEVGEALKT-VLGKKETLVEDKLSLLNSNWIAVT 1664

Query: 579  LKEEE--ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK---WQQFNSD 633
             + EE    L  +     T  Q    I +W ++QA  L  E   K+  QK    ++  ++
Sbjct: 1665 SRAEEWLNLLLEYQKHMETFDQNVDHITKW-IIQADTLLDESEKKKPQQKEDVLKRLKAE 1723

Query: 634  LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR-KAIILSINLCSP 692
            LN I   +  T ++   L         + +E QI +L     A+ HR K    SI L   
Sbjct: 1724 LNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL--K 1781

Query: 693  EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHE--MSHGLLLM 750
            E  Q +S    D+Q  L  +     +  +L EE     +D     +G  +  +  G  L 
Sbjct: 1782 ELEQFNS----DIQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQ 1835

Query: 751  LENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE---SQLRVASLQDMSCQLLVN 807
                D RK E + I             +QL+Q KH  L+   SQ R  +L+         
Sbjct: 1836 QRITDERKREEIKI------------KQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1883

Query: 808  AEGTD---CLEAKEK--VHVIGNRLKLLLKEVSRHI-KELEKLLDVSSSQQDLSSWSSA 860
             +  D   CL+  EK    +   R +  +KE+ R + K+ E+L  V    + LS   +A
Sbjct: 1884 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA 1942



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 186/962 (19%), Positives = 396/962 (41%), Gaps = 138/962 (14%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            I  +L   N RW+ L +    R K L++++ + Q+ +K++  ++  L  I+ +LA  I  
Sbjct: 1340 INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA- 1398

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
            D  ++ ++ +   E Q++Q D+  H       ++L E+  H+          ++ Q+   
Sbjct: 1399 DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK-------EAAQRVLS 1442

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERTAAFPS--S 189
             +D   + +  +SM+        +RL+QK     + FE  L+ S     E     P+  +
Sbjct: 1443 QIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVKMHLPALET 1490

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
              V   V + +L       + + E  +++E++ K  R++ ++ +T++   L + V     
Sbjct: 1491 KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1550

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAK 307
             ++ L  +VT   ++L+  +    +     + +  WL   D++LT          ++ ++
Sbjct: 1551 HYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE 1610

Query: 308  IKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD--------------AAIIEEE 350
            +   KA Q+EI      ++ I   GE L   + K E L                +  EE 
Sbjct: 1611 VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEW 1670

Query: 351  LDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----SAALSDLH- 401
            L+ L  Y +  E F + V+   K +I+     DE +   +  + ED      A L+D+  
Sbjct: 1671 LNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELNDIRP 1729

Query: 402  ----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSIPLEWDHDY 451
                  D++A+ + +     +    L +P  SE + R    S        SIPL+    +
Sbjct: 1730 KVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF 1786

Query: 452  D-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVMIPESPEAY 498
            +     L   LE+ + + +  ++E+   D +    G V         L   +  E     
Sbjct: 1787 NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1846

Query: 499  VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------SKTPTGPEL 551
            +K+ +  ++        L SQ R+    +    +Q + Q +++++       K  + PE 
Sbjct: 1847 IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEP 1906

Query: 552  --DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL 609
              +   K   + L +    +++V+R    L E+  ++     +  T+ Q +    RW  +
Sbjct: 1907 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS---KRWREI 1959

Query: 610  QAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR--LELSTDIQ 661
            +++ A  + L   Q      +       D+    +++  T   E+  + +  LE+   + 
Sbjct: 1960 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 2019

Query: 662  TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-----------DLQDRLS 710
              +L  K  ++L K  +  K I  S+   S       SK++             LQ+ LS
Sbjct: 2020 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079

Query: 711  QMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNEIVPIDSN 767
            Q++ +W++V  + ++ +G    ++ + + FH   ++ +  L   E   R+      I  N
Sbjct: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPEN 2135

Query: 768  LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 827
             +    + + K+L      + + Q  V +L     +++  +  TD    +EK+  +  R 
Sbjct: 2136 WEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2192

Query: 828  KLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNRQKTPR 885
            + + K++S   K LE+  ++ S  Q+DL+ +    +E D   S+    G+    ++K  +
Sbjct: 2193 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2252

Query: 886  GK 887
             K
Sbjct: 2253 VK 2254



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 60/290 (20%), Positives = 126/290 (43%), Gaps = 22/290 (7%)

Query: 11  ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 70
           E + +E++ ++  +N RW+ L      +   L   L+ +Q  ++ +  L  WL   E   
Sbjct: 414 EDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERT 471

Query: 71  AK----PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            K    P+  D    E+++R++ + + LQ D+E+    V S+ ++  V+    D  + D 
Sbjct: 472 RKMEEEPLGPDL---EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV----DESSGDH 524

Query: 127 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
              ++++  + L  RW NIC  + +R + +++    WQ+  ++   F  WL   E     
Sbjct: 525 ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE----- 579

Query: 187 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK-QMVH 245
             +   I+T   ++  +  +  +++      LE   KQ        + D   +LK + V 
Sbjct: 580 -DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK-KKQSMGKLYSLKQDLLSTLKNKSVT 637

Query: 246 EGNQRW-DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT 294
           +  + W DN  +   +++++L+    Q  +  T     L   T M+   T
Sbjct: 638 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 687



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 71/324 (21%), Positives = 136/324 (41%), Gaps = 30/324 (9%)

Query: 492 PESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRSKTPTGP 549
           PE       L E+ + N     +ALE  +  L  A D  + Q  I     +++ +  T  
Sbjct: 325 PEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT-- 381

Query: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTETQTAGV 602
                ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++       
Sbjct: 382 -----HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS------- 429

Query: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
             RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L  D++ 
Sbjct: 430 --RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLED 485

Query: 663 IELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 721
           ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  RW  +C 
Sbjct: 486 LKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICR 545

Query: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
             E+   LLQD L++ Q   E        L   +   N+I         E+L    K L 
Sbjct: 546 WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQK-LA 604

Query: 782 QIKHELLESQLRVASLQDMSCQLL 805
            +K +L + +  +  L  +   LL
Sbjct: 605 VLKADLEKKKQSMGKLYSLKQDLL 628


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 179/862 (20%), Positives = 341/862 (39%), Gaps = 155/862 (17%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            EI+ ++  +N RW+ L      R  +L + L+ +Q+  K +  L  WL   E  + K   
Sbjct: 389  EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQK--- 443

Query: 76   YDSCNSEE----IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
             ++C  ++    +Q+ L E + LQ D+E     V S+ ++  ++  +    AT    D +
Sbjct: 444  METCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQL 503

Query: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE------RTAA 185
            Q+    L  RW  +C  + ER  +++E   LWQ+ L++    + WL   E      +T+ 
Sbjct: 504  QK----LGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSN 559

Query: 186  FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
            F     +  +V +  + K +   ++  + L QL  I +   +L   ++      +     
Sbjct: 560  FKDQKELSVSVRRLAILKEDMEMKR--QTLDQLSEIGQDVGQLLDNSKASK--KINSDSE 615

Query: 246  EGNQRWDNLQKR-------VTSILRRL-KHFIGQREEFETAR------------------ 279
            E  QRWD+L +R       VT  + +L    I Q++  ET R                  
Sbjct: 616  ELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPP 675

Query: 280  -------------------------DSILVWLTEMDLQLTNIEHFSEC-DVQAKIKQLKA 313
                                     + IL W T   +Q T I+ + +  D     K+LKA
Sbjct: 676  PPKKRQIHVDIEAKKKFDAISAELLNWILKWKTA--IQTTEIKEYMKMQDTSEMKKKLKA 733

Query: 314  FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 371
             ++E      + +++   G+ L+E+   E L    I+  L+++    + V   +E   +K
Sbjct: 734  LEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERK 793

Query: 372  LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 431
               + L +D +    +  ELE      +  W   ++                     SE 
Sbjct: 794  ---IQLQEDINAYFKQLDELEKVIKTKE-EWVKHTS--------------------ISES 829

Query: 432  SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSD--V 489
            S +  P+  DS   E  +   L   +E  M+RA  S         DF  RG         
Sbjct: 830  SRQSLPSLKDSCQRELTNLLGLHPKIE--MARASCSALMSQPSAPDFVQRGFDSFLGRYQ 887

Query: 490  MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGP 549
             + E+ E   +  EN +K   G H+ LE+ ++ L   L+DS  + Q + N++        
Sbjct: 888  AVQEAVEDRQQHLENELKGQPG-HAYLET-LKTLKDVLNDSENKAQVSLNVLNDLAKVEK 945

Query: 550  ELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL-----PGFVNLHSTETQTAGVID 604
             L        K L E    +++ K   HKL EE ++L     P    L+  E     V  
Sbjct: 946  ALQEK-----KTLDEI---LENQKPALHKLAEETKALEKNVHPDVEKLYKQEFD--DVQG 995

Query: 605  RWELLQAQALSKELRMKQNLQ-KWQQFNSDLNSIWAWLGDTEEELEQLQRLE-------- 655
            +W  L+   +SK+L + + +    + F +D   I  W+   ++ L + Q  +        
Sbjct: 996  KWNKLKV-LVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQR 1054

Query: 656  -------LSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP----EFTQADSKESRD 704
                      +I+TIE  +K +KE++   + R   +  I         ++     K S++
Sbjct: 1055 QLDQCSAFVNEIETIESSLKNMKEIE--TNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKE 1112

Query: 705  LQDRLSQMNGRWDRVCSL------LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
            +  + S+++   ++  +L      ++EW    ++  ++    ++    L   +E + R K
Sbjct: 1113 IATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAK 1172

Query: 759  NEIVPIDSNLDAEILQDHHKQL 780
             ++  +   +  +IL+D+ K L
Sbjct: 1173 EDV--LQKEVRVKILKDNIKLL 1192



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 168/942 (17%), Positives = 361/942 (38%), Gaps = 166/942 (17%)

Query: 13   KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
            +A +I   L ++N +W  +  + + R       +   +Q   +++ L  W+   E     
Sbjct: 1942 EAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE---- 1997

Query: 73   PIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 129
             ++ D+C    S ++++    QQEL+  I  H    A++    + ++       + A+  
Sbjct: 1998 -LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL----SQADGS 2052

Query: 130  SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 189
             +++    L++RW  I A   +R+ +++   +   K+         WL  +E      S+
Sbjct: 2053 FLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRST 2112

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL------KQM 243
                 T   E L++     +++     +L+ +N    R   E  +D + SL       + 
Sbjct: 2113 -----TELGENLQELRDLTQEMEVHAEKLKWLN----RTELEMLSDKSLSLPERDKISES 2163

Query: 244  VHEGNQRWDNLQKRVTSILRRL-------------KHFIGQREEFETARDSILV------ 284
            +   N  W+ + + V + L+                H   Q+    ++   I V      
Sbjct: 2164 LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTS 2223

Query: 285  -----------------WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKI 325
                             WL  +D  L +NI    + + +   + ++K  + ++   H ++
Sbjct: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283

Query: 326  EQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD---DE 381
            + +    + L  K+   D    I E+L+ ++         VE   ++L  + +     D+
Sbjct: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343

Query: 382  HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL---------------SLAQP 426
            H     EL  +  A L  L    R     L+ Q S N  L               ++ Q 
Sbjct: 2344 HREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVMAFDNVLQK 2400

Query: 427  LRSERSGRDT---PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGA 483
            L  E    DT     + + +   W +      D ++A+     +     +D ++F     
Sbjct: 2401 LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLK--- 2457

Query: 484  VGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI--RQLGKALDDSRFQIQQTENII 541
                   I E+     + T N + + S   +AL+  I  R+L + + D + +I    +I 
Sbjct: 2458 ------WIQEA-----ETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIF 2506

Query: 542  RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 601
            +S       +D + +  +K LG      +    L+H+L +  +                 
Sbjct: 2507 KS-------IDGNRQKMVKALGNS----EEATMLQHRLDDMNQ----------------- 2538

Query: 602  VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 661
               RW  L+A++ S    ++ + +KW +    L  +  WL   +EEL+  +++ +  D+ 
Sbjct: 2539 ---RWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK--KQMPIGGDVP 2593

Query: 662  TIELQIKKLKELQK-----------AVDHRKAIILSINLCSPEFTQAD------------ 698
             ++LQ    K L++           AVD  +  +    + +PE  + +            
Sbjct: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEER 2653

Query: 699  -SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRR 757
              K ++ ++ + S++  +W+ + ++   W+  +  AL + +        L   ++  +  
Sbjct: 2654 AQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESV 2713

Query: 758  KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 817
            +N   P+  +L  + LQDH +++M  + E+     +V ++ D+S Q L   +    L+  
Sbjct: 2714 RNGWKPV-GDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-LSPLDLHPSLKMS 2771

Query: 818  EKVHVIGNRLKLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 858
             ++  +  R KLL   V   +K+L++   D   S Q   S S
Sbjct: 2772 RQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTS 2813



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 54/294 (18%), Positives = 127/294 (43%), Gaps = 14/294 (4%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            KAS     + I  KL +V ++W      +  R ++L++ ++   Q D +       +   
Sbjct: 2296 KASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            E+ L    +      + + +++++ Q L +++      V +  N+ + LL +  +  T  
Sbjct: 2356 EARL---YILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTR- 2411

Query: 127  ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT--- 183
               ++++ T  L   W N+     +R+  +E  WR  Q    D   F  W++ +E T   
Sbjct: 2412 ---NVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNV 2468

Query: 184  ---AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE-NRTDSACS 239
               A+   ++     +A+E  ++ +  Q ++       + I+   +++ +    ++ A  
Sbjct: 2469 LVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATM 2528

Query: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL 293
            L+  + + NQRW++L+ +  SI   L+    +      + + ++ WL   D +L
Sbjct: 2529 LQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEEL 2582



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 150/863 (17%), Positives = 327/863 (37%), Gaps = 133/863 (15%)

Query: 44   ETLVAVQQLDKNMSSLR-------TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 96
            ET   V ++D ++ S +       TWL   E    +     S + EE++ +    +    
Sbjct: 299  ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDI-SDDVEEVKDQFATHEAFMM 357

Query: 97   DIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKI 156
            ++  H + V SVL     L+       +D E   IQ+    L+ RW  +   SM+R+ ++
Sbjct: 358  ELTAHQSSVGSVLQAGNQLI--TQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRL 415

Query: 157  EETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLT 216
             +     QK      +   WL  +E       +  +      +++K  +    +     +
Sbjct: 416  HDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPL-----DDDVKSLQKLLEEHKSLQS 468

Query: 217  QLELINKQYRRLAR------ENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFI 269
             LE    +   L        EN  +SA + L+  + +  +RW  + +       RL+   
Sbjct: 469  DLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEIN 528

Query: 270  GQREEFETARDSILVWLTEMDLQLTNIEHFS---ECDVQAKIKQLKAFQQEISLNHNKIE 326
               +E    +  +  WLTE +  L  ++  +   + ++   +++L   ++++ +    ++
Sbjct: 529  ILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLD 588

Query: 327  QIIAQGE---QLIEKSEP-----LDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLP 378
            Q+   G+   QL++ S+       D+  + +  D L +  ++   +V +   KL    +P
Sbjct: 589  QLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIP 648

Query: 379  DDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPA 438
                     + +L ++  + +     +S   L  P P     + +   + +++      A
Sbjct: 649  ---------QKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHV--DIEAKKKFDAISA 697

Query: 439  SVDSIPLEWD--------HDYDLSRD----------LESAMSRALPSEDEEGQDDKDFYL 480
             + +  L+W          +Y   +D          LE      +P  DE  Q  +   L
Sbjct: 698  ELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQ--IL 755

Query: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
               +G   +   E      K++ +  KN S     LE +I QL + ++    Q+ + E +
Sbjct: 756  VEQMGKEGLPTEEIKNVLEKVS-SEWKNVSQHLEDLERKI-QLQEDINAYFKQLDELEKV 813

Query: 541  IRSKTPTGPEL---DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS--- 594
            I++K          ++S +    L   C   + ++  L  K++    S    ++  S   
Sbjct: 814  IKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPD 873

Query: 595  -TETQTAGVIDRWELLQAQALSKELRMKQNL--QKWQQFNSDLNSIWAWLGDTEEELEQL 651
              +      + R++ +Q     ++  ++  L  Q    +   L ++   L D+E + +  
Sbjct: 874  FVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQ-- 931

Query: 652  QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRL-- 709
              L +  D+  +E  +++ K L + ++++K  +  +     E T+A  K      ++L  
Sbjct: 932  VSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKL----AEETKALEKNVHPDVEKLYK 987

Query: 710  ---SQMNGRWDRV------------------------CSLLEEWRGLLQDALMQCQGFHE 742
                 + G+W+++                         +++E+W   ++D LM+ Q    
Sbjct: 988  QEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQG 1047

Query: 743  MSHGLLLMLENIDRRKNEIVPIDSNLD--AEI-------------------LQDHHKQLM 781
               GL   L+      NEI  I+S+L    EI                   L D+  QL 
Sbjct: 1048 DDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLE 1107

Query: 782  QIKHELLESQLRVASLQDMSCQL 804
            ++  E+   + R++  Q+ +  L
Sbjct: 1108 KLSKEIATQKSRLSESQEKAANL 1130



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 70/296 (23%), Positives = 129/296 (43%), Gaps = 20/296 (6%)

Query: 551  LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 610
            LD   K Y K L E    +++V +    + +++++     N    + Q   +   +  L 
Sbjct: 1475 LDKCMKLY-KTLSEVKLEVETVIKTGRHIVQKQQT----DNPKGMDEQLTSLKVLYNDLG 1529

Query: 611  AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE-LSTDIQTIELQIKK 669
            AQ    +  +++  Q  ++   +  S+  WL  TE EL Q    E L  D+ T   +I  
Sbjct: 1530 AQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDT---EISW 1586

Query: 670  LKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 729
             K + K ++ RKA + +I   S             L++RL  +N  W RV +  E+W   
Sbjct: 1587 AKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNT 1646

Query: 730  LQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLE 789
            L +   Q + F      +   L   +   +EI    ++   EI++       ++  EL +
Sbjct: 1647 LMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVK-------RLVSELDD 1699

Query: 790  SQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL 845
            + L+V +++D +  +L+NA G+   E  E      NR     ++VS+HIK  + L+
Sbjct: 1700 ANLQVENVRDQAL-ILMNARGSSSRELVEPKLAELNR---NFEKVSQHIKSAKLLI 1751



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 58/249 (23%), Positives = 112/249 (44%), Gaps = 25/249 (10%)

Query: 493 ESPEAYVKLTENAIKNTSGDHS-ALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL 551
           ESP A    T   +      +  ALE  +  L  A D  + Q   ++++   K     + 
Sbjct: 294 ESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVK-----DQ 348

Query: 552 DTSYKGYMKLLGECSSSIDSVKRLEHKL------KEEEESLPGFVNLHSTETQTAGVIDR 605
             +++ +M  L    SS+ SV +  ++L       +EEE           + Q   +  R
Sbjct: 349 FATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEE--------FEIQEQMTLLNAR 400

Query: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
           WE L+ +++ ++ R+   L + Q+    L  + AWL  TEE +++++   L  D+++++ 
Sbjct: 401 WEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQK 458

Query: 666 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRD--LQDRLSQMNGRWDRVCSLL 723
            +++ K LQ  ++  +  + S+          +S ES    L+D+L ++  RW  VC   
Sbjct: 459 LLEEHKSLQSDLEAEQVKVNSLT-HMVVIVDENSGESATAILEDQLQKLGERWTAVCRWT 517

Query: 724 EEWRGLLQD 732
           EE    LQ+
Sbjct: 518 EERWNRLQE 526



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 173/923 (18%), Positives = 357/923 (38%), Gaps = 144/923 (15%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            I  KL   N R++ L  L  ++   L++ L  +++ D+ +  L+  L  ++ +L   +  
Sbjct: 1307 ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLT- 1365

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
            D  ++ ++ +   E Q++Q +I  H       L L E+  +      T  E  + +  ++
Sbjct: 1366 DRIDAFQVPQ---EAQKIQAEISAHE------LTLEELRRNMRSQPLTSPESRTARGGSQ 1416

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
             +D   R +  +S + +L  ++     Q+ LD   R  D +K+            V   V
Sbjct: 1417 -MDVLQRKLREVSTKFQL-FQKPANFEQRMLD-CKRVLDGVKAELHVL---DVKDVDPDV 1470

Query: 197  AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA-------CSLKQMVHE-GN 248
             +  L K     + + E   ++E + K  R + ++ +TD+         SLK + ++ G 
Sbjct: 1471 IQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGA 1530

Query: 249  QRWDNLQ--KRVTSILRRLKHFIGQREEFETARDSILV-----------------W---- 285
            Q  +  Q  +R + + R++K       E+ +A ++ LV                 W    
Sbjct: 1531 QVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNV 1590

Query: 286  -------------LTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEIS----------LNH 322
                         +TE    L N+   SE  ++ ++  L A    +           +NH
Sbjct: 1591 LKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNH 1650

Query: 323  NKIEQI-----------IAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 371
                +I           + Q E L+++ E    +  EE +  L     +   +VE    +
Sbjct: 1651 QNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQ 1710

Query: 372  LIRLPLPDDEHDLSDRELELEDSAALS----DLHWHDRSADSLLSPQPSSNLSLSLAQPL 427
             + L    +    S REL     A L+     +  H +SA  L++ +P       L Q L
Sbjct: 1711 ALILM---NARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEP-------LYQCL 1760

Query: 428  RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSE--DEEGQDDKDFYLRGAVG 485
             +  +        D   LE D + ++ + +E  +  +   E  DEE    ++   RG   
Sbjct: 1761 VTTETFETGVPFSDLEKLENDIE-NMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEM 1819

Query: 486  LSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK- 544
            L   M     E  ++L    +        A+  Q R++G+     R  +  T+ ++    
Sbjct: 1820 LHQPMEDNKKEK-IRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINK 1878

Query: 545  ----------TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL-------- 586
                      +   PEL+T+      +  + S   DS+K ++ +L +  E +        
Sbjct: 1879 ILLCMDDVELSLNVPELNTA------IYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQP 1932

Query: 587  --------PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 638
                    P  + +  T TQ      +W+ +      ++    + +++W+QF+ DLN + 
Sbjct: 1933 DVILEASGPEAIQIRDTLTQLNA---KWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLT 1989

Query: 639  AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
             W+ + EE L        S D++   +     +EL+  +   +    ++N       Q  
Sbjct: 1990 QWITEAEELLVDTCAPGGSLDLEKARIH---QQELEVGISSHQPSFAALNRTGDGIVQKL 2046

Query: 699  SK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRR 757
            S+ +   L+++L+ +N RWD + + +++ +  L+    Q   +      ++  L   +  
Sbjct: 2047 SQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHA 2106

Query: 758  KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 817
              +    +   + + L+D   Q M++  E L+  L    L+ +S + L   E     E+ 
Sbjct: 2107 MQKRSTTELGENLQELRD-LTQEMEVHAEKLK-WLNRTELEMLSDKSLSLPERDKISESL 2164

Query: 818  EKVHVIGNRLKLLLKEVSRHIKE 840
              V++  N+   + +EV   +KE
Sbjct: 2165 RTVNMTWNK---ICREVPTTLKE 2184



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 59/289 (20%), Positives = 133/289 (46%), Gaps = 32/289 (11%)

Query: 568 SIDSVKRLE-----HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQ 622
           +ID+++ +E     +K + EEE+    +N+ ST  +     +  E  +A+  S    +  
Sbjct: 259 TIDAIREVETLPRKYKKECEEEA----INIQSTAPE-----EEHESPRAETPSTVTEVDM 309

Query: 623 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKA 682
           +L  +Q     L  +  WL   E+  ++    ++S D++ ++ Q    +     +   ++
Sbjct: 310 DLDSYQ---IALEEVLTWLLSAEDTFQEQD--DISDDVEEVKDQFATHEAFMMELTAHQS 364

Query: 683 IILSI----NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 738
            + S+    N    + T +D +E  ++Q++++ +N RW+ +     + +  L D LM+ Q
Sbjct: 365 SVGSVLQAGNQLITQGTLSDEEEF-EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQ 423

Query: 739 --GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA-EILQDHHKQLMQIKHELLESQLRVA 795
                ++S  L L  E I  +K E  P+D ++ + + L + HK L   + +L   Q++V 
Sbjct: 424 KKQLQQLSAWLTLTEERI--QKMETCPLDDDVKSLQKLLEEHKSL---QSDLEAEQVKVN 478

Query: 796 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 844
           SL  M   +  N+  +     ++++  +G R   + +        L+++
Sbjct: 479 SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 72/361 (19%), Positives = 139/361 (38%), Gaps = 26/361 (7%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE-LAKPIV 75
            ++ +LG    + + L   IA +  +L E+      L K+++ ++ W+   E E L +   
Sbjct: 1095 VQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD--AECDSIQQ 133
            Y S   EE++  + E +  + D+ +    V  + +  ++L     +   +  +E + + +
Sbjct: 1155 YKS--PEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLE 1212

Query: 134  ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER----TAAFPSS 189
              + L  R R  C         +EE W  W + L        WL + E     T   P  
Sbjct: 1213 NYQLLCNRIRGKCHT-------LEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEK 1265

Query: 190  SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
            +  +     E L+  E+  R   +  TQ+  +    + L      D   S K  +   N 
Sbjct: 1266 TDAV----NEALESLESVLRHPADNRTQIRELG---QTLIDGGILDDIISEK--LEAFNS 1316

Query: 250  RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK 309
            R+++L     S    L+  +    E +     +   L E+D QLT        D     +
Sbjct: 1317 RYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTY-LTDRIDAFQVPQ 1375

Query: 310  QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYH 369
            + +  Q EIS +   +E++          S     A    ++D L+R  +EV  + + + 
Sbjct: 1376 EAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQ 1435

Query: 370  K 370
            K
Sbjct: 1436 K 1436



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 79/396 (19%), Positives = 153/396 (38%), Gaps = 74/396 (18%)

Query: 557  GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS---------TETQTAGVIDRWE 607
            G  + L +CS+ ++ ++ +E  LK  +E      NL S          +T+      + E
Sbjct: 1051 GLQRQLDQCSAFVNEIETIESSLKNMKEIE---TNLRSGPVAGIKTWVQTRLGDYQTQLE 1107

Query: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQ 666
             L  +  +++ R+ ++ +K      DL  +  W+   EEE LE+    +   ++++   +
Sbjct: 1108 KLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEE 1167

Query: 667  IKKLKE--LQKAV------DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718
            +K+ KE  LQK V      D+ K +   +     E T   +    + Q   +++ G+   
Sbjct: 1168 MKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGK--- 1224

Query: 719  VCSLLEE-----------------WRGLLQDALMQCQGFHEMSHGLLLMLENIDR----- 756
             C  LEE                 W   L++ +   +   E +  +   LE+++      
Sbjct: 1225 -CHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHP 1283

Query: 757  --RKNEIVPIDSNL-DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 813
               + +I  +   L D  IL D    ++  K E   S+    S    S Q+ +  +    
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDD----IISEKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339

Query: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTS 873
             E  + + V+   L  L K+++ ++ +      V    Q + +  SA EL        T 
Sbjct: 1340 RETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHEL--------TL 1391

Query: 874  GRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS 909
                 N +  P            ++SP SR+ +GGS
Sbjct: 1392 EELRRNMRSQP------------LTSPESRTARGGS 1415



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 32/145 (22%), Positives = 65/145 (44%), Gaps = 8/145 (5%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G+ + +   ++  S ++ KL  +N RW  ++  +  R  +LK     V +    +  +  
Sbjct: 2039 GDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIIC 2098

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            WL   E  + K       ++ E+   L E ++L +++E H+  +   LN  E+ +   D 
Sbjct: 2099 WLTKAEHAMQKR------STTELGENLQELRDLTQEMEVHAEKL-KWLNRTELEMLS-DK 2150

Query: 122  CATDAECDSIQQATRNLDRRWRNIC 146
              +  E D I ++ R ++  W  IC
Sbjct: 2151 SLSLPERDKISESLRTVNMTWNKIC 2175



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 53/285 (18%), Positives = 122/285 (42%), Gaps = 23/285 (8%)

Query: 3    ERLAKA-SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            +++ KA  +  +A+ ++++L  +N RW  L    A+    L+ +     +L  ++  L  
Sbjct: 2514 QKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIK 2573

Query: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
            WL   + EL K +     +   +Q + +  + L+R++++    V + ++   V L D   
Sbjct: 2574 WLNMKDEELKKQMPIGG-DVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPI 2632

Query: 122  CATDAECDSIQQATR-NLDRRWRNICAMSMERRLKIEETWRL-------WQKFLD----- 168
             A +    ++Q  T    + R + I     ++  +++E W         WQK +D     
Sbjct: 2633 EAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEK 2692

Query: 169  --DYSRFEDWLKSSERTA-----AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 221
              D     D L +  + A      +     ++    ++ ++K  AF+ ++     +++ +
Sbjct: 2693 LRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTV 2752

Query: 222  NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 266
            N    +L+  +   S   + + + + N RW  LQ  V   L++L+
Sbjct: 2753 NDLSSQLSPLDLHPS-LKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 23/91 (25%), Positives = 42/91 (46%)

Query: 9   SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
           S ES  + +E +L K+ +RW  +      R  +L+E  +  Q+L +    L+ WL   E 
Sbjct: 491 SGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEE 550

Query: 69  ELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 99
            L K    +  + +E+   +     L+ D+E
Sbjct: 551 ALNKVQTSNFKDQKELSVSVRRLAILKEDME 581


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 142/735 (19%), Positives = 303/735 (41%), Gaps = 70/735 (9%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++ H  +A  I  +L +++D W+ +   +  R   L E    +QQ  +++   ++WL+  
Sbjct: 1010 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS-KLQQFLRDLDDFQSWLSRT 1068

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            ++ +A   + ++    E ++ L + + ++ +I+ +      + ++ E++        TDA
Sbjct: 1069 QTAIASEDMPNTLT--EAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQG----QTDA 1122

Query: 127  ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
            +   ++Q  + LD  W  +  M  E R  +      +Q+FL D  + E +L + E   A 
Sbjct: 1123 QYMFLRQRLQALDTGWNELHKM-WENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1181

Query: 187  PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 246
                  +   A+  +KK E F   +     ++  + +  RRL  +   +S   +++ V  
Sbjct: 1182 TEMPTTLEG-AEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD-RIQEKVDS 1239

Query: 247  GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 306
             + R    ++  + +L RLK     ++  +  ++ + +W+ E  L   ++ +    ++ +
Sbjct: 1240 IDDRHRKNRETASELLMRLKDNRDLQKFLQDCQE-LSLWINEKMLTAQDMSYDEARNLHS 1298

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 366
            K  + +AF  E++ N   +++I  +G QLI + +P   A+++E+L  L +  + +    +
Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLESTTQ 1357

Query: 367  RYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-LHWHDR--SADSLLSPQPSSNLSLSL 423
               ++L          D +  EL  +  A L   LH  +    +D       S N+ L  
Sbjct: 1358 TKAQRLF---------DANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1408

Query: 424  AQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP-SEDEEGQDDKDF-YLR 481
             Q L ++   R                    +++E   S+A   S++ +  D+ D   L 
Sbjct: 1409 QQMLENQMEVR-------------------KKEIEELQSQAQALSQEGKSTDEVDSKRLT 1449

Query: 482  GAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK----ALDDSRFQIQQT 537
                  +++ P +   +  L    I   + D   +E +I  +G+    A         QT
Sbjct: 1450 VQTKFMELLEPLNERKHNLLASKEIHQFNRD---VEDEILWVGERMPLATSTDHGHNLQT 1506

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 597
              ++  K  T   L    +G+          ID +      +  +  SL    +  +   
Sbjct: 1507 VQLLIKKNQT---LQKEIQGH-------QPRIDDIFERSQNIVTDSSSL----SAEAIRQ 1552

Query: 598  QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 657
            + A +   W LL  +   K  R  +   + QQ+  D     AW+  +E+EL  +   E +
Sbjct: 1553 RLADLKQLWGLL-IEETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSE-EKA 1608

Query: 658  TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 717
             D Q+    +KK + L++AV+     +  ++  S         ES  +  R S+++  + 
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668

Query: 718  RVCSLLEEWRGLLQD 732
             +  L EE RG L +
Sbjct: 1669 GLKDLAEERRGKLDE 1683



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 191/901 (21%), Positives = 336/901 (37%), Gaps = 130/901 (14%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +  +L  + H S+  EI+ +  K+N RW    +L+  +   L   L ++Q      +  +
Sbjct: 898  IARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETK 955

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +W+        K  V +S  ++++   L     LQR +    TG+   L   E  L D  
Sbjct: 956  SWIRE------KTKVIES--TQDLGNDLAGVMALQRKL----TGMERDLVAIEAKLSDLQ 1003

Query: 121  ACATDAECDSIQQATRNLDRR------WRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
              A   E +   QA   L R       W  +      R   + E  +L Q+FL D   F+
Sbjct: 1004 KEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQ 1062

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 234
             WL  ++   A       + T A++ L + E  + ++       + + +    +  + +T
Sbjct: 1063 SWLSRTQTAIASEDMPNTL-TEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQT 1120

Query: 235  DSACS-LKQMVHEGNQRWDNLQK------RVTSILRRLKHFIG---QREEFETARDSILV 284
            D+    L+Q +   +  W+ L K       + S     + F+    Q E F   ++ +L 
Sbjct: 1121 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1180

Query: 285  WLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA 344
              TEM   L   E        A IK+ + F   +  N  KI  ++  G +L+     +++
Sbjct: 1181 H-TEMPTTLEGAE--------AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN-INS 1230

Query: 345  AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHD 404
              I+E++D +                        DD H   +RE   E    L D    +
Sbjct: 1231 DRIQEKVDSI------------------------DDRHR-KNRETASELLMRLKD----N 1261

Query: 405  RSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR- 463
            R     L  Q    LSL + + + + +                D  YD +R+L S   + 
Sbjct: 1262 RDLQKFL--QDCQELSLWINEKMLTAQ----------------DMSYDEARNLHSKWLKH 1303

Query: 464  -ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT-SGDHS---ALES 518
             A  +E    ++  D   +  + L    I E PE     TE  +K   +G H     LES
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQL----ISEKPE-----TEAVVKEKLTGLHKMWEVLES 1354

Query: 519  QIRQLGKALDDSRFQIQQTENIIR-SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH 577
              +   + L D+      T++     K   G E       Y K L   +  +   + LE+
Sbjct: 1355 TTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLEN 1414

Query: 578  KL---KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-----RMKQNL---QK 626
            ++   K+E E L       S E ++   +D  + L  Q    EL       K NL   ++
Sbjct: 1415 QMEVRKKEIEELQSQAQALSQEGKSTDEVDS-KRLTVQTKFMELLEPLNERKHNLLASKE 1473

Query: 627  WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD-HRKAIIL 685
              QFN D+     W+G   E +      +   ++QT++L IKK + LQK +  H+  I  
Sbjct: 1474 IHQFNRDVEDEILWVG---ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1530

Query: 686  SINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSH 745
                     T + S  +  ++ RL+ +   W  +    E+    L++A    Q + + + 
Sbjct: 1531 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1590

Query: 746  GLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL 805
                M E      +E    D      +L+ H     QI  + +E           + + L
Sbjct: 1591 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKH-----QILEQAVEDYAETVHQLSKTSRAL 1645

Query: 806  V---NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 862
            V   + E       + KV  +   LK L +E    + E  +L  ++    DL  W +  E
Sbjct: 1646 VADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAERE 1705

Query: 863  L 863
            +
Sbjct: 1706 V 1706



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 145/737 (19%), Positives = 297/737 (40%), Gaps = 109/737 (14%)

Query: 28   WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK 87
            W++LL+L+ AR ++L+  L  +Q++ + M  +  W+  +     K +V     S++  + 
Sbjct: 497  WEYLLELLRARRQRLEMNL-GLQKIFQEMLYIMDWMDEM-----KVLVL----SQDYGKH 546

Query: 88   LNEQQELQRDIEKHSTGVASVLNLCEVLLH---DCDACATDAE----CDS--IQQATRNL 138
            L   ++L   ++KH+   A +    E +          ATD E    CD   I+    ++
Sbjct: 547  LLGVEDL---LQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHM 603

Query: 139  DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK 198
            +  ++ +C ++ ERR ++EE+ RLW KF  + +  E W++  E+  +     G   T   
Sbjct: 604  EFCYQELCQLAAERRARLEESRRLW-KFFWEMAEEEGWIREKEKILS-SDDYGKDLTSVM 661

Query: 199  EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 258
              L K  AF+ ++       E   K+   +  E    S   +++ +    ++W NL+ ++
Sbjct: 662  RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE-KIRERIIYIREQWANLE-QL 719

Query: 259  TSILRRLKHFIGQREEFETARDSILVWLTEM--DLQLTNIEHFSECDVQAKIKQLKAFQQ 316
            ++I ++         +F+   D I  W+ ++   +  +++ H  E   Q+ +K+ K   +
Sbjct: 720  SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH-DEYSTQSLVKKHKDVAE 778

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 376
            EI+     ++ +  Q   L    E  ++  +   L  +    +EV         +L RL 
Sbjct: 779  EIANYRPTLDTLHEQASAL--PQEHAESPDVRGRLSGIEERYKEV--------AELTRL- 827

Query: 377  LPDDEHDLSDRELELEDSAALSDLH--------WHDRSADSLLSPQ-PSSNLSLSLAQ-- 425
                      R+  L+D+ AL  +         W D     L + Q P     L + Q  
Sbjct: 828  ----------RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 877

Query: 426  --PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE-EGQDDKDFYLRG 482
               L  E + + +  +V +          ++R L   M    PSE E + Q DK   L  
Sbjct: 878  FESLEPEMNNQASRVAVVN---------QIARQL---MHSGHPSEKEIKAQQDK---LNT 922

Query: 483  AVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
                   ++    +A   L+  +I+N   + +  +S IR+  K ++ ++           
Sbjct: 923  RWSQFRELVDRKKDAL--LSALSIQNYHLECNETKSWIREKTKVIESTQ----------- 969

Query: 543  SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT--- 599
                   +L     G M L  + +     +  +E KL + ++      + H  + Q    
Sbjct: 970  -------DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1022

Query: 600  --AGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 657
              A + D WE ++    ++E  + +   K QQF  DL+   +WL  T+  +         
Sbjct: 1023 RLAEISDVWEEMKTTLKNREASLGE-ASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTL 1081

Query: 658  TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQDRLSQMNGRW 716
            T+ + +  Q + +K     +D+ +     +       TQ  +  +   L+ RL  ++  W
Sbjct: 1082 TEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1138

Query: 717  DRVCSLLEEWRGLLQDA 733
            + +  + E  + LL  +
Sbjct: 1139 NELHKMWENRQNLLSQS 1155



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 76/410 (18%), Positives = 170/410 (41%), Gaps = 74/410 (18%)

Query: 9    SHESKAS-EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVA---VQQLDKNMSSLRTWLA 64
            S E K++ E++ K   V  ++  LL+ +  R    K  L+A   + Q ++++     W+ 
Sbjct: 1434 SQEGKSTDEVDSKRLTVQTKFMELLEPLNER----KHNLLASKEIHQFNRDVEDEILWVG 1489

Query: 65   HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 124
                 LA    +   N + +Q  + + Q LQ++I+ H   +  +    + ++ D  + + 
Sbjct: 1490 E-RMPLATSTDHGH-NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1547

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            +A    I+Q   +L + W  +   + +R  ++EE  R  Q++  D +  E W+   E   
Sbjct: 1548 EA----IRQRLADLKQLWGLLIEETEKRHRRLEEAHRA-QQYYFDAAEAEAWMSEQE--- 1599

Query: 185  AFPSSSGVIYTVAKEE----------LKKFEAFQRQVHECLTQLELINKQYRRLARENRT 234
                    +Y +++E+          LKK +  ++ V +    +  ++K  R L  ++  
Sbjct: 1600 --------LYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1651

Query: 235  DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREE-FETAR--DSILVWLTEMDL 291
            +S     + +     + D L   +  +    +  + +R   F+  R  D +  W+ E ++
Sbjct: 1652 ES-----ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV 1706

Query: 292  QLTNIEHFSECDVQAKIKQ-LKAFQQEI-SLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE 349
               + E   + +    +++  + F ++  ++   +++ +    ++LI      DAA I E
Sbjct: 1707 VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHS-DAATIAE 1765

Query: 350  ELD------------------------ELRRY---CQEVFGRVERYHKKL 372
              D                        EL ++    +E+FGR++  HKKL
Sbjct: 1766 WKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL 1815



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 145/862 (16%), Positives = 328/862 (38%), Gaps = 88/862 (10%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE +    H   + +I  ++  + ++W +L  L A R K+L+E  + + Q   +   +  
Sbjct: 688  GEDMIAEEHFG-SEKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDA 745

Query: 62   WLAHIESELAKPIV-YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+  I   ++   V +D  +++ + +K        +D+ +    +A+     + L     
Sbjct: 746  WMLDILKIVSSSDVGHDEYSTQSLVKK-------HKDVAEE---IANYRPTLDTLHEQAS 795

Query: 121  ACATD-AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            A   + AE   ++     ++ R++ +  ++  R+  +++T  L++ F  +    E W+  
Sbjct: 796  ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF-SEADACELWIDE 854

Query: 180  SER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
             E+       P     +  +      +FE+ + +++   +++ ++N+  R+L       S
Sbjct: 855  KEQWLNNMQIPEKLEDLEVIQ----HRFESLEPEMNNQASRVAVVNQIARQLMHSGH-PS 909

Query: 237  ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
               +K    + N RW   ++ V      L   +   + +    +    W+ E    + + 
Sbjct: 910  EKEIKAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIEST 968

Query: 297  EHFSE--CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDEL 354
            +        V A  ++L   ++++     K+  +  + E+L E   P  A  I   L E+
Sbjct: 969  QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-ESEHPDQAQAILSRLAEI 1027

Query: 355  RRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQ 414
                +E+                   +  L +RE  L +++ L           S LS  
Sbjct: 1028 SDVWEEM-------------------KTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1068

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
             ++  S  +   L           ++ +    ++ DY   RD+   ++        +GQ 
Sbjct: 1069 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVT--------QGQT 1120

Query: 475  DKDF-YLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALE--SQIRQLGKALDDSR 531
            D  + +LR  +   D    E      K+ EN     S  H+  +     +Q    L++  
Sbjct: 1121 DAQYMFLRQRLQALDTGWNE----LHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQE 1176

Query: 532  FQIQQTENIIRSKTPTGPELD-TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 590
            + +  TE      T  G E      + +M  +      I++V     +L  +     G +
Sbjct: 1177 YVLAHTE---MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSD-----GNI 1228

Query: 591  NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 650
            N    + +   + DR    +  A    +R+K N +  Q+F  D   +  W+ +     + 
Sbjct: 1229 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDN-RDLQKFLQDCQELSLWINE-----KM 1282

Query: 651  LQRLELSTDIQTIELQIKKLKE--LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
            L   ++S D +   L  K LK       +   K  +  I     +      +    ++++
Sbjct: 1283 LTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1341

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDA------LMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            L+ ++  W+ + S  +     L DA         C    +  HGL   +++ D  K ++ 
Sbjct: 1342 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGK-DLT 1400

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 822
             ++  L  + + ++  ++ + + E L+SQ +  S +  S   + +   T   +  E +  
Sbjct: 1401 SVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1460

Query: 823  IGNRLKLLL--KEVSRHIKELE 842
            +  R   LL  KE+ +  +++E
Sbjct: 1461 LNERKHNLLASKEIHQFNRDVE 1482



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 41/271 (15%)

Query: 4    RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 63
            RL  A    KA +I+ +  +V + W+ LLD   +R  +L +T    +     +  L  W+
Sbjct: 1856 RLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWM 1914

Query: 64   AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 123
              +  ++         +S E+   +N  Q ++ +I+  +    + + L + LL       
Sbjct: 1915 EDVIRQIEAQEKPRDVSSVEL--LMNNHQGIKAEIDARNDSFTTCIELGKSLL------- 1965

Query: 124  TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW-------QKFLDDYSRFEDW 176
                      A+  +  +   +     E   K E+ W  W        +F  D S  E W
Sbjct: 1966 -----ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WLRLILEVHQFSRDASVAEAW 2019

Query: 177  LKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVH---------ECLTQLEL--INK 223
            L   E    + SS  +  +V + E  +K+ EAF++            E LT LEL  + +
Sbjct: 2020 LLGQE---PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRR 2076

Query: 224  QYRRLARENRTDSACSLKQMVH--EGNQRWD 252
            Q     R+ R  S     ++    E  Q+WD
Sbjct: 2077 QQEEEERKRRPPSPEPSTKVSEEAESQQQWD 2107


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 142/735 (19%), Positives = 303/735 (41%), Gaps = 70/735 (9%)

Query: 7    KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 66
            ++ H  +A  I  +L +++D W+ +   +  R   L E    +QQ  +++   ++WL+  
Sbjct: 1023 ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS-KLQQFLRDLDDFQSWLSRT 1081

Query: 67   ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 126
            ++ +A   + ++    E ++ L + + ++ +I+ +      + ++ E++        TDA
Sbjct: 1082 QTAIASEDMPNTLT--EAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQG----QTDA 1135

Query: 127  ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
            +   ++Q  + LD  W  +  M  E R  +      +Q+FL D  + E +L + E   A 
Sbjct: 1136 QYMFLRQRLQALDTGWNELHKM-WENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH 1194

Query: 187  PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 246
                  +   A+  +KK E F   +     ++  + +  RRL  +   +S   +++ V  
Sbjct: 1195 TEMPTTLEG-AEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD-RIQEKVDS 1252

Query: 247  GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 306
             + R    ++  + +L RLK     ++  +  ++ + +W+ E  L   ++ +    ++ +
Sbjct: 1253 IDDRHRKNRETASELLMRLKDNRDLQKFLQDCQE-LSLWINEKMLTAQDMSYDEARNLHS 1311

Query: 307  KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 366
            K  + +AF  E++ N   +++I  +G QLI + +P   A+++E+L  L +  + +    +
Sbjct: 1312 KWLKHQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLESTTQ 1370

Query: 367  RYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-LHWHDR--SADSLLSPQPSSNLSLSL 423
               ++L          D +  EL  +  A L   LH  +    +D       S N+ L  
Sbjct: 1371 TKAQRLF---------DANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1421

Query: 424  AQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP-SEDEEGQDDKDF-YLR 481
             Q L ++   R                    +++E   S+A   S++ +  D+ D   L 
Sbjct: 1422 QQMLENQMEVR-------------------KKEIEELQSQAQALSQEGKSTDEVDSKRLT 1462

Query: 482  GAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK----ALDDSRFQIQQT 537
                  +++ P +   +  L    I   + D   +E +I  +G+    A         QT
Sbjct: 1463 VQTKFMELLEPLNERKHNLLASKEIHQFNRD---VEDEILWVGERMPLATSTDHGHNLQT 1519

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 597
              ++  K  T   L    +G+          ID +      +  +  SL    +  +   
Sbjct: 1520 VQLLIKKNQT---LQKEIQGH-------QPRIDDIFERSQNIVTDSSSL----SAEAIRQ 1565

Query: 598  QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 657
            + A +   W LL  +   K  R  +   + QQ+  D     AW+  +E+EL  +   E +
Sbjct: 1566 RLADLKQLWGLL-IEETEKRHRRLEEAHRAQQYYFDAAEAEAWM--SEQELYMMSE-EKA 1621

Query: 658  TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 717
             D Q+    +KK + L++AV+     +  ++  S         ES  +  R S+++  + 
Sbjct: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681

Query: 718  RVCSLLEEWRGLLQD 732
             +  L EE RG L +
Sbjct: 1682 GLKDLAEERRGKLDE 1696



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 191/901 (21%), Positives = 336/901 (37%), Gaps = 130/901 (14%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            +  +L  + H S+  EI+ +  K+N RW    +L+  +   L   L ++Q      +  +
Sbjct: 911  IARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETK 968

Query: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            +W+        K  V +S  ++++   L     LQR +    TG+   L   E  L D  
Sbjct: 969  SWIRE------KTKVIES--TQDLGNDLAGVMALQRKL----TGMERDLVAIEAKLSDLQ 1016

Query: 121  ACATDAECDSIQQATRNLDRR------WRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 174
              A   E +   QA   L R       W  +      R   + E  +L Q+FL D   F+
Sbjct: 1017 KEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQ 1075

Query: 175  DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT 234
             WL  ++   A       + T A++ L + E  + ++       + + +    +  + +T
Sbjct: 1076 SWLSRTQTAIASEDMPNTL-TEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQT 1133

Query: 235  DSACS-LKQMVHEGNQRWDNLQK------RVTSILRRLKHFIG---QREEFETARDSILV 284
            D+    L+Q +   +  W+ L K       + S     + F+    Q E F   ++ +L 
Sbjct: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193

Query: 285  WLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA 344
              TEM   L   E        A IK+ + F   +  N  KI  ++  G +L+     +++
Sbjct: 1194 H-TEMPTTLEGAE--------AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN-INS 1243

Query: 345  AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHD 404
              I+E++D +                        DD H   +RE   E    L D    +
Sbjct: 1244 DRIQEKVDSI------------------------DDRHR-KNRETASELLMRLKD----N 1274

Query: 405  RSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR- 463
            R     L  Q    LSL + + + + +                D  YD +R+L S   + 
Sbjct: 1275 RDLQKFL--QDCQELSLWINEKMLTAQ----------------DMSYDEARNLHSKWLKH 1316

Query: 464  -ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT-SGDHS---ALES 518
             A  +E    ++  D   +  + L    I E PE     TE  +K   +G H     LES
Sbjct: 1317 QAFMAELASNKEWLDKIEKEGMQL----ISEKPE-----TEAVVKEKLTGLHKMWEVLES 1367

Query: 519  QIRQLGKALDDSRFQIQQTENIIR-SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH 577
              +   + L D+      T++     K   G E       Y K L   +  +   + LE+
Sbjct: 1368 TTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLEN 1427

Query: 578  KL---KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-----RMKQNL---QK 626
            ++   K+E E L       S E ++   +D  + L  Q    EL       K NL   ++
Sbjct: 1428 QMEVRKKEIEELQSQAQALSQEGKSTDEVDS-KRLTVQTKFMELLEPLNERKHNLLASKE 1486

Query: 627  WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD-HRKAIIL 685
              QFN D+     W+G   E +      +   ++QT++L IKK + LQK +  H+  I  
Sbjct: 1487 IHQFNRDVEDEILWVG---ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1543

Query: 686  SINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSH 745
                     T + S  +  ++ RL+ +   W  +    E+    L++A    Q + + + 
Sbjct: 1544 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1603

Query: 746  GLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL 805
                M E      +E    D      +L+ H     QI  + +E           + + L
Sbjct: 1604 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKH-----QILEQAVEDYAETVHQLSKTSRAL 1658

Query: 806  V---NAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 862
            V   + E       + KV  +   LK L +E    + E  +L  ++    DL  W +  E
Sbjct: 1659 VADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAERE 1718

Query: 863  L 863
            +
Sbjct: 1719 V 1719



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 145/737 (19%), Positives = 297/737 (40%), Gaps = 109/737 (14%)

Query: 28   WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRK 87
            W++LL+L+ AR ++L+  L  +Q++ + M  +  W+  +     K +V     S++  + 
Sbjct: 510  WEYLLELLRARRQRLEMNL-GLQKIFQEMLYIMDWMDEM-----KVLVL----SQDYGKH 559

Query: 88   LNEQQELQRDIEKHSTGVASVLNLCEVLLH---DCDACATDAE----CDS--IQQATRNL 138
            L   ++L   ++KH+   A +    E +          ATD E    CD   I+    ++
Sbjct: 560  LLGVEDL---LQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHM 616

Query: 139  DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK 198
            +  ++ +C ++ ERR ++EE+ RLW KF  + +  E W++  E+  +     G   T   
Sbjct: 617  EFCYQELCQLAAERRARLEESRRLW-KFFWEMAEEEGWIREKEKILS-SDDYGKDLTSVM 674

Query: 199  EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 258
              L K  AF+ ++       E   K+   +  E    S   +++ +    ++W NL+ ++
Sbjct: 675  RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSE-KIRERIIYIREQWANLE-QL 732

Query: 259  TSILRRLKHFIGQREEFETARDSILVWLTEM--DLQLTNIEHFSECDVQAKIKQLKAFQQ 316
            ++I ++         +F+   D I  W+ ++   +  +++ H  E   Q+ +K+ K   +
Sbjct: 733  SAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGH-DEYSTQSLVKKHKDVAE 791

Query: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 376
            EI+     ++ +  Q   L    E  ++  +   L  +    +EV         +L RL 
Sbjct: 792  EIANYRPTLDTLHEQASAL--PQEHAESPDVRGRLSGIEERYKEV--------AELTRL- 840

Query: 377  LPDDEHDLSDRELELEDSAALSDLH--------WHDRSADSLLSPQ-PSSNLSLSLAQ-- 425
                      R+  L+D+ AL  +         W D     L + Q P     L + Q  
Sbjct: 841  ----------RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890

Query: 426  --PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE-EGQDDKDFYLRG 482
               L  E + + +  +V +          ++R L   M    PSE E + Q DK   L  
Sbjct: 891  FESLEPEMNNQASRVAVVN---------QIARQL---MHSGHPSEKEIKAQQDK---LNT 935

Query: 483  AVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
                   ++    +A   L+  +I+N   + +  +S IR+  K ++ ++           
Sbjct: 936  RWSQFRELVDRKKDAL--LSALSIQNYHLECNETKSWIREKTKVIESTQ----------- 982

Query: 543  SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT--- 599
                   +L     G M L  + +     +  +E KL + ++      + H  + Q    
Sbjct: 983  -------DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1035

Query: 600  --AGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 657
              A + D WE ++    ++E  + +   K QQF  DL+   +WL  T+  +         
Sbjct: 1036 RLAEISDVWEEMKTTLKNREASLGE-ASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTL 1094

Query: 658  TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQDRLSQMNGRW 716
            T+ + +  Q + +K     +D+ +     +       TQ  +  +   L+ RL  ++  W
Sbjct: 1095 TEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1151

Query: 717  DRVCSLLEEWRGLLQDA 733
            + +  + E  + LL  +
Sbjct: 1152 NELHKMWENRQNLLSQS 1168



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 76/410 (18%), Positives = 170/410 (41%), Gaps = 74/410 (18%)

Query: 9    SHESKAS-EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVA---VQQLDKNMSSLRTWLA 64
            S E K++ E++ K   V  ++  LL+ +  R    K  L+A   + Q ++++     W+ 
Sbjct: 1447 SQEGKSTDEVDSKRLTVQTKFMELLEPLNER----KHNLLASKEIHQFNRDVEDEILWVG 1502

Query: 65   HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 124
                 LA    +   N + +Q  + + Q LQ++I+ H   +  +    + ++ D  + + 
Sbjct: 1503 E-RMPLATSTDHGH-NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1560

Query: 125  DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
            +A    I+Q   +L + W  +   + +R  ++EE  R  Q++  D +  E W+   E   
Sbjct: 1561 EA----IRQRLADLKQLWGLLIEETEKRHRRLEEAHRA-QQYYFDAAEAEAWMSEQE--- 1612

Query: 185  AFPSSSGVIYTVAKEE----------LKKFEAFQRQVHECLTQLELINKQYRRLARENRT 234
                    +Y +++E+          LKK +  ++ V +    +  ++K  R L  ++  
Sbjct: 1613 --------LYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1664

Query: 235  DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREE-FETAR--DSILVWLTEMDL 291
            +S     + +     + D L   +  +    +  + +R   F+  R  D +  W+ E ++
Sbjct: 1665 ES-----ERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV 1719

Query: 292  QLTNIEHFSECDVQAKIKQ-LKAFQQEI-SLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE 349
               + E   + +    +++  + F ++  ++   +++ +    ++LI      DAA I E
Sbjct: 1720 VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHS-DAATIAE 1778

Query: 350  ELD------------------------ELRRY---CQEVFGRVERYHKKL 372
              D                        EL ++    +E+FGR++  HKKL
Sbjct: 1779 WKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL 1828



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 145/862 (16%), Positives = 328/862 (38%), Gaps = 88/862 (10%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            GE +    H   + +I  ++  + ++W +L  L A R K+L+E  + + Q   +   +  
Sbjct: 701  GEDMIAEEHFG-SEKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDIDA 758

Query: 62   WLAHIESELAKPIV-YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+  I   ++   V +D  +++ + +K        +D+ +    +A+     + L     
Sbjct: 759  WMLDILKIVSSSDVGHDEYSTQSLVKK-------HKDVAEE---IANYRPTLDTLHEQAS 808

Query: 121  ACATD-AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            A   + AE   ++     ++ R++ +  ++  R+  +++T  L++ F  +    E W+  
Sbjct: 809  ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF-SEADACELWIDE 867

Query: 180  SER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
             E+       P     +  +      +FE+ + +++   +++ ++N+  R+L       S
Sbjct: 868  KEQWLNNMQIPEKLEDLEVIQ----HRFESLEPEMNNQASRVAVVNQIARQLMHSGH-PS 922

Query: 237  ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
               +K    + N RW   ++ V      L   +   + +    +    W+ E    + + 
Sbjct: 923  EKEIKAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIEST 981

Query: 297  EHFSE--CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDEL 354
            +        V A  ++L   ++++     K+  +  + E+L E   P  A  I   L E+
Sbjct: 982  QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-ESEHPDQAQAILSRLAEI 1040

Query: 355  RRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQ 414
                +E+                   +  L +RE  L +++ L           S LS  
Sbjct: 1041 SDVWEEM-------------------KTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081

Query: 415  PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQD 474
             ++  S  +   L           ++ +    ++ DY   RD+   ++        +GQ 
Sbjct: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVT--------QGQT 1133

Query: 475  DKDF-YLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALE--SQIRQLGKALDDSR 531
            D  + +LR  +   D    E      K+ EN     S  H+  +     +Q    L++  
Sbjct: 1134 DAQYMFLRQRLQALDTGWNE----LHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQE 1189

Query: 532  FQIQQTENIIRSKTPTGPELD-TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 590
            + +  TE      T  G E      + +M  +      I++V     +L  +     G +
Sbjct: 1190 YVLAHTE---MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSD-----GNI 1241

Query: 591  NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 650
            N    + +   + DR    +  A    +R+K N +  Q+F  D   +  W+ +     + 
Sbjct: 1242 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDN-RDLQKFLQDCQELSLWINE-----KM 1295

Query: 651  LQRLELSTDIQTIELQIKKLKE--LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDR 708
            L   ++S D +   L  K LK       +   K  +  I     +      +    ++++
Sbjct: 1296 LTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1354

Query: 709  LSQMNGRWDRVCSLLEEWRGLLQDA------LMQCQGFHEMSHGLLLMLENIDRRKNEIV 762
            L+ ++  W+ + S  +     L DA         C    +  HGL   +++ D  K ++ 
Sbjct: 1355 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGK-DLT 1413

Query: 763  PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 822
             ++  L  + + ++  ++ + + E L+SQ +  S +  S   + +   T   +  E +  
Sbjct: 1414 SVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1473

Query: 823  IGNRLKLLL--KEVSRHIKELE 842
            +  R   LL  KE+ +  +++E
Sbjct: 1474 LNERKHNLLASKEIHQFNRDVE 1495



 Score = 33.1 bits (74), Expect = 1.3
 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 41/271 (15%)

Query: 4    RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 63
            RL  A    KA +I+ +  +V + W+ LLD   +R  +L +T    +     +  L  W+
Sbjct: 1869 RLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWM 1927

Query: 64   AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 123
              +  ++         +S E+   +N  Q ++ +I+  +    + + L + LL       
Sbjct: 1928 EDVIRQIEAQEKPRDVSSVEL--LMNNHQGIKAEIDARNDSFTTCIELGKSLL------- 1978

Query: 124  TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW-------QKFLDDYSRFEDW 176
                      A+  +  +   +     E   K E+ W  W        +F  D S  E W
Sbjct: 1979 -----ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WLRLILEVHQFSRDASVAEAW 2032

Query: 177  LKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVH---------ECLTQLEL--INK 223
            L   E    + SS  +  +V + E  +K+ EAF++            E LT LEL  + +
Sbjct: 2033 LLGQE---PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRR 2089

Query: 224  QYRRLARENRTDSACSLKQMVH--EGNQRWD 252
            Q     R+ R  S     ++    E  Q+WD
Sbjct: 2090 QQEEEERKRRPPSPEPSTKVSEEAESQQQWD 2120


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 145/747 (19%), Positives = 305/747 (40%), Gaps = 58/747 (7%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G++L   +H +K  E+  ++ +V   W+ LL+    +  KL+E     QQ ++N+  +  
Sbjct: 635  GQKLIDVNHYAK-DEVAARMNEVISLWKKLLEATELKGIKLREANQQ-QQFNRNVEDIEL 692

Query: 62   WLAHIESELAKPIV-YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            WL  +E  LA      D  N + +Q+K      L+ D+  H   +  +           D
Sbjct: 693  WLYEVEGHLASDDYGKDLTNVQNLQKK---HALLEADVAAHQDRIDGITIQARQFQ---D 746

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            A   DAE  +I++    L  R+  +    + R+ K+ ++ RL Q F D     E W++  
Sbjct: 747  AGHFDAE--NIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE-ETWIREK 803

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            E  AA  ++ G      +  LKK +A Q ++     +++ + ++   +  E    +A  +
Sbjct: 804  EPIAA-STNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF-AAEDV 861

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            K  +HE NQ+W+ L+ + +   + L+  +  ++ F  A ++   W+ E +  + + ++  
Sbjct: 862  KAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA-ESWMREKEPIVGSTDYGK 920

Query: 301  ECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQ 359
            + D  +A +K+ +A   ++S   + I+ +  Q +   ++  P D    +E +  L  Y Q
Sbjct: 921  DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY-Q 979

Query: 360  EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
            E   R     K  I   L     D    ++E+ D         + +  D   S    + L
Sbjct: 980  EKSPREVTMKKGDILTLLNSTNKDW--WKVEVNDRQGFVPAA-YVKKLDPAQSASRENLL 1036

Query: 420  SLSLAQPLRSERSGRDTPASVD--SIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
                +  LR E+    T  + +  S+ L      +L   L          E  +G  +K 
Sbjct: 1037 EEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLEL------GEKRKGMLEKS 1090

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQT 537
                       ++  E+ E    + E     TS +  A   Q+  L K  DD +  ++  
Sbjct: 1091 C-------KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKAN 1143

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE-----------HKLKEEEESL 586
            E+ ++       +L++         G  +  + +V++ E            K     +S 
Sbjct: 1144 ESRLKDINKVAEDLESE--------GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195

Query: 587  PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 646
               V+  +T      + +RW  LQ Q   +  ++  +  + Q+F+ D +    W+   EE
Sbjct: 1196 RLMVHTVATFNSIKELNERWRSLQ-QLAEERSQLLGSAHEVQRFHRDADETKEWI---EE 1251

Query: 647  ELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQ 706
            + + L       D+ +++   +K +  ++ +      + S+   +    Q+  + + DLQ
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQ 1311

Query: 707  DRLSQMNGRWDRVCSLLEEWRGLLQDA 733
            ++ +++N  W  +    ++ +  L D+
Sbjct: 1312 EKCTELNQAWSSLGKRADQRKAKLGDS 1338



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 136/737 (18%), Positives = 297/737 (40%), Gaps = 100/737 (13%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            ++ +L  + D+WQ L+   A + +KLKE     Q  +  +     WL+ +E+ LA     
Sbjct: 1629 VKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYG 1687

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                S  +   L + Q L+ DI  H   +  + +  + L+      ++  +   ++    
Sbjct: 1688 KDLAS--VNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-----TSSAFDTSQVKDKRD 1740

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
             ++ R++ I +M+  RR K+ E+ RL Q F  D    E W+K  ++        G   T 
Sbjct: 1741 TINGRFQKIKSMAASRRAKLNESHRLHQ-FFRDMDDEESWIK-EKKLLVGSEDYGRDLTG 1798

Query: 197  AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 256
             +   KK +  + ++      ++ +    ++L+ +N T     ++Q + +  + W  L++
Sbjct: 1799 VQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN-TIGKEEIQQRLAQFVEHWKELKQ 1857

Query: 257  RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAKIKQLKAF 314
               +  +RL+  + + ++F    +    W+ E  + L   E + +    +Q  +K+ +AF
Sbjct: 1858 LAAARGQRLEESL-EYQQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAF 1915

Query: 315  QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR 374
            + + +++ +++  +   G+ LI+K+                 + + +  +++  + K   
Sbjct: 1916 ETDFTVHKDRVNDVCTNGQDLIKKN---------------NHHEENISSKMKGLNGK--- 1957

Query: 375  LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR 434
              + D E   + R+ +L++++A    +W     +S +  + +S         L+++  GR
Sbjct: 1958 --VSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS---------LKTDDYGR 2006

Query: 435  DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 494
            D  +    +  +   D  L    +  ++     +D+         L  A  +    I   
Sbjct: 2007 DLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQ---------LLAAKHVQSKAIEAR 2057

Query: 495  PEAYVKLTENAIKNTSGDHSAL---ESQIRQ-----LGKALDDSRFQIQQTENIIRSKT- 545
              + +K     + N++     L   +S  R+     L  A   S F     EN     T 
Sbjct: 2058 HASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFN-SWFENAEEDLTD 2116

Query: 546  PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF---VNLHSTETQTAGV 602
            P         K   +      SS+ S +   ++L E +  +  F    N ++  T  A +
Sbjct: 2117 PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEA-L 2175

Query: 603  IDRWELLQAQALSKEL-------RMKQNLQKWQQFNSDLNSIWAWLGDT----------- 644
             + W  LQ     +EL       R ++N +  Q+F    N+   W+ +T           
Sbjct: 2176 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMV 2235

Query: 645  ------EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
                  E +LE  +R     +I+ +  Q+KK+++L  A++  +A+IL       ++T+  
Sbjct: 2236 EESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAME--EALIL-----DNKYTEHS 2286

Query: 699  SKESRDLQDRLSQMNGR 715
            +       D+L Q+  R
Sbjct: 2287 TVGLAQQWDQLDQLGMR 2303



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 163/893 (18%), Positives = 349/893 (39%), Gaps = 118/893 (13%)

Query: 6    AKASHESKASE--IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 63
            AK   E    E  I+ K  +VN  WQ L  L   R  KL      VQ+ ++++    +W+
Sbjct: 213  AKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWI 271

Query: 64   AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 123
               E  +A         S++  R L   Q L R  E     +A++ +  + L  + D   
Sbjct: 272  KEKEQLMA---------SDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQ 322

Query: 124  TD--AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
                     IQ     L   W  I  ++ ER  ++ +++RL Q+FL D+     W+   +
Sbjct: 323  QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL-QRFLADFRDLTSWVTEMK 381

Query: 182  RTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
               A  ++  +   VA  E  L + +  + ++                 A E+   SA  
Sbjct: 382  ---ALINADELASDVAGAEALLDRHQEHKGEID----------------AHEDSFKSADE 422

Query: 240  LKQ-MVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILV---------W 285
              Q ++  G+   D +++++T +       L+ +  +R+++E   D  L          W
Sbjct: 423  SGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNW 482

Query: 286  LTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA 344
            +++ +  L N +     D V+A +K+ + F++ +S    KI  +     +LI+ +     
Sbjct: 483  MSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH---- 538

Query: 345  AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHD 404
                  ++++      +  R    H++ +R            R  +L DS  L       
Sbjct: 539  ----YAMEDVATRRDALLSRRNALHERAMR------------RRAQLADSFHLQQFF--- 579

Query: 405  RSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRA 464
            R +D L S   +  +  +  +  +   + +       +   E   +      LE A  + 
Sbjct: 580  RDSDELKS-WVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKA-GQK 637

Query: 465  LPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLG 524
            L   +   +D+    +   + L   ++  +    +KL E              +Q +Q  
Sbjct: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE-------------ANQQQQFN 684

Query: 525  KALDDSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKLLGECSSSIDSVKRLEHKLKE 581
            + ++D    + + E  + S    G +L       K +  L  + ++  D +  +  + ++
Sbjct: 685  RNVEDIELWLYEVEGHLASDD-YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743

Query: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
             +++  G  +  + + +   ++ R+E L+   ++++ ++  +L+  Q F  D+     W+
Sbjct: 744  FQDA--GHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWI 800

Query: 642  GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
             + E       R     D+  ++  +KK + LQ  +   +  I ++        +     
Sbjct: 801  REKEPIAASTNR---GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA 857

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 761
            + D++ +L ++N +W+ + +   + R  L+D+L   Q F + +     M E         
Sbjct: 858  AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK-------- 909

Query: 762  VPIDSNLDAEILQDHHKQLMQIKHELLESQL-----RVASLQDMSCQLLVNAEGTDCLEA 816
             PI  + D    +D  + L++ KHE L S L      + +L++ +         TD    
Sbjct: 910  EPIVGSTDYGKDEDSAEALLK-KHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSV 869
            KE V  + +  +   +EV+  +K+ + L  ++S+ +D   W   +  D  G V
Sbjct: 969  KELVLALYDYQEKSPREVT--MKKGDILTLLNSTNKD---WWKVEVNDRQGFV 1016



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 168/911 (18%), Positives = 355/911 (38%), Gaps = 133/911 (14%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            ERL + SH   A +++ K  ++N  W  L      R  KL ++   +Q+   +   L +W
Sbjct: 1297 ERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH-DLQRFLSDFRDLMSW 1354

Query: 63   LAHIES-----ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
            +  I       ELAK    D   +E +   L   QE + +I+  +    +     + LL 
Sbjct: 1355 INGIRGLVSSDELAK----DVTGAEAL---LERHQEHRTEIDARAGTFQAFEQFGQQLLA 1407

Query: 118  DCDACATDAE--CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 175
                 + + +   D + Q   +L++ W       ++RR+ +++   L Q F  D  + E+
Sbjct: 1408 HGHYASPEIKQKLDILDQERADLEKAW-------VQRRMMLDQCLEL-QLFHRDCEQAEN 1459

Query: 176  WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH---ECLTQLELINKQYRRLAREN 232
            W+ + E           + +V +  +KK E F + ++   E +  L+    Q        
Sbjct: 1460 WMAAREAFLNTEDKGDSLDSV-EALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA 1518

Query: 233  RTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDL 291
            + D +    +++     RW  L+ ++  I +R K    Q  ++F    D I  W++E  L
Sbjct: 1519 KGDISSRRNEVL----DRWRRLKAQM--IEKRSKLGESQTLQQFSRDVDEIEAWISEK-L 1571

Query: 292  QLTNIEHFSE-CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK-----SEPLDAA 345
            Q  + E + +  ++Q+K ++ +AF+ E+  N ++I  +I  G  LIE+     SE    A
Sbjct: 1572 QTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKA 1631

Query: 346  IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDR 405
             +    D+ +   Q+   + ++                L +   +   +  + D  +   
Sbjct: 1632 RLAALADQWQFLVQKSAEKSQK----------------LKEANKQQNFNTGIKDFDFWLS 1675

Query: 406  SADSLLSPQ------PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES 459
              ++LL+ +       S N  L   Q L ++ S  +            D   DL+   +S
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE------------DRLKDLNSQADS 1723

Query: 460  AMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQ 519
             M+ +  + D     DK   + G       M   +     KL E+              +
Sbjct: 1724 LMTSS--AFDTSQVKDKRDTINGRFQKIKSM---AASRRAKLNES-------------HR 1765

Query: 520  IRQLGKALDDSRFQIQQTENIIRS----KTPTGPE-LDTSYKGYMKLLGECSSSIDSVKR 574
            + Q  + +DD    I++ + ++ S    +  TG + L   +K     L     +I  V  
Sbjct: 1766 LHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLD 1825

Query: 575  LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL 634
               KL ++       +     + + A  ++ W+ L+  A ++  R++++L+ +QQF +++
Sbjct: 1826 TGKKLSDDNT-----IGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLE-YQQFVANV 1879

Query: 635  NSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF 694
                AW+    E++  +   +    +  I+  +KK +  +      K  +  +     + 
Sbjct: 1880 EEEEAWI---NEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1936

Query: 695  TQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENI 754
             + ++    ++  ++  +NG+     S LE+     +  L +   F + +    ++   I
Sbjct: 1937 IKKNNHHEENISSKMKGLNGK----VSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWI 1992

Query: 755  DRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR------VASLQDMSCQLL--- 805
              ++N +   D   D   +     Q +  K E  ++ L+      +A++  +  QLL   
Sbjct: 1993 GEKENSLKTDDYGRDLSSV-----QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAK 2047

Query: 806  ------VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 858
                  + A     ++   ++       K  L E   H +++E L L  +      +SW 
Sbjct: 2048 HVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWF 2107

Query: 859  SADELDTSGSV 869
               E D +  V
Sbjct: 2108 ENAEEDLTDPV 2118



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 141/749 (18%), Positives = 293/749 (39%), Gaps = 88/749 (11%)

Query: 129 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 188
           + IQ+  + +  R+     +S  RR K+E+++R +Q F  D    E W++   + A+  +
Sbjct: 13  EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 189 SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 248
                 T  + +L+K +AF+ +V      +  +++    +  E    S  +++  + E +
Sbjct: 72  YKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE-TIRTRLMELH 128

Query: 249 QRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDLQLTNIEHFSECD-VQA 306
           ++W+ L +++    + +K    Q+  ++    + ++ W+ + +  +T+ E   + + V+ 
Sbjct: 129 RQWELLLEKMRE--KGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEV 186

Query: 307 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 366
             K+ + FQ +++ +  ++ ++     +LI++  P +  +I+ + DE+    Q + G   
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLKGLAL 245

Query: 367 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
           +   KL                         +++   +R  D  +S            Q 
Sbjct: 246 QRQGKLF----------------------GAAEVQRFNRDVDETISWIKEKE------QL 277

Query: 427 LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAV 484
           + S+  GRD  ASV ++  + +    L RDL +     +AL +E +         L+ + 
Sbjct: 278 MASDDFGRDL-ASVQALLRKHE---GLERDLAALEDKVKALCAEADR--------LQQSH 325

Query: 485 GLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544
            LS   I    E  +   E      +  H+ L    R L + L D R     T  +   K
Sbjct: 326 PLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQRFLADFR---DLTSWVTEMK 381

Query: 545 T-PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV------------N 591
                 EL +   G   LL         +   E   K  +ES    +             
Sbjct: 382 ALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREK 441

Query: 592 LHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 651
           L     + A +++ WEL + Q         +     Q F  D   +  W+   E     L
Sbjct: 442 LTVLSEERAALLELWELRRQQ--------YEQCMDLQLFYRDTEQVDNWMSKQE---AFL 490

Query: 652 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 711
              +L   + ++E  +KK ++ +K++  ++  I +++  + +  Q +     D+  R   
Sbjct: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550

Query: 712 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 771
           +  R + +       R  L D+    Q F +       + E +    +E     SNL  +
Sbjct: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK 610

Query: 772 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLL 830
           + Q H       + EL  +Q R+ +L+    +L+ VN    D + A+    VI    KLL
Sbjct: 611 V-QKH----QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN-EVISLWKKLL 664

Query: 831 LKEVSRHIK--ELEKLLDVSSSQQDLSSW 857
                + IK  E  +    + + +D+  W
Sbjct: 665 EATELKGIKLREANQQQQFNRNVEDIELW 693



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 162/873 (18%), Positives = 340/873 (38%), Gaps = 102/873 (11%)

Query: 14  ASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
           ASE I  +L +++ +W+ LL+ +  +  KL +    VQ L +    +  W+   E+ +  
Sbjct: 116 ASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL-RECEDVMDWINDKEAIVT- 173

Query: 73  PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVAS-------VLNLCEVLLHDCDACATD 125
                   SEE+ + L   + LQ+  E+  T +A+       V      L+ +       
Sbjct: 174 --------SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE-----QH 220

Query: 126 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            E + I+     ++  W+ +  ++++R+ K+     + Q+F  D      W+K  E+  A
Sbjct: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMA 279

Query: 186 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                  + +V +  L+K E  +R +     +++ +  +  RL +++   SA  ++    
Sbjct: 280 SDDFGRDLASV-QALLRKHEGLERDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKRE 337

Query: 246 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE-CDV 304
           E    W+ ++        RL      +      RD +  W+TEM   +   E  S+    
Sbjct: 338 ELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD-LTSWVTEMKALINADELASDVAGA 396

Query: 305 QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE--ELDELRRYCQEVF 362
           +A + + +  + EI  + +  +     G+ L+         + E+   L E R    E++
Sbjct: 397 EALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELW 456

Query: 363 GRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS-DLHWHDRSADSLLSPQPSSNLSL 421
               + +++ + L L   + +  D  +  +++  L+ DL     S ++LL        SL
Sbjct: 457 ELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL 516

Query: 422 SLAQPLRSERSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSRALPSED----EEGQD 474
           S  +        + T     +  L  ++ Y   D++   ++ +SR     +       Q 
Sbjct: 517 SAQEE-------KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569

Query: 475 DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
              F+L+     SD +     E     T+ A K    D S L+      GK      F+ 
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK----DPSNLQ------GKVQKHQAFEA 619

Query: 535 QQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS 594
           + + N  R        +D   K   KL+            + H  K+E            
Sbjct: 620 ELSANQSR--------IDALEKAGQKLID-----------VNHYAKDE------------ 648

Query: 595 TETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL 654
              +   VI  W+ L      K +++++  Q+ QQFN ++  I  WL + E  L      
Sbjct: 649 VAARMNEVISLWKKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEGHLASDDYG 707

Query: 655 ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNG 714
           +  T++Q ++   KK   L+  V   +  I  I + + +F  A   ++ +++ +   +  
Sbjct: 708 KDLTNVQNLQ---KKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVA 764

Query: 715 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL- 773
           R++ +   +   +  L D+L   Q F ++        E    R+ E +   +N   +++ 
Sbjct: 765 RYEALKEPMVARKQKLADSLRLQQLFRDVED------EETWIREKEPIAASTNRGKDLIG 818

Query: 774 -QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            Q+  K+   ++ E+   + R+ ++       +V        + K K+H +  + + L  
Sbjct: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKG-NAMVEEGHFAAEDVKAKLHELNQKWEALKA 877

Query: 833 EVSRHIKELEKLLDVS---SSQQDLSSWSSADE 862
           + S+  ++LE  L      +   +  SW    E
Sbjct: 878 KASQRRQDLEDSLQAQQYFADANEAESWMREKE 910



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 53/201 (26%), Positives = 85/201 (42%), Gaps = 40/201 (19%)

Query: 3    ERLAKASH-ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD-------K 54
            ++L  A H +SKA  IE +   +  RW  LL   AAR KKL E     ++++       K
Sbjct: 2041 DQLLAAKHVQSKA--IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098

Query: 55   NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 114
              S+  +W  + E +L  P+    CNS E  + L E  +  R     S+  A    L E+
Sbjct: 2099 KASAFNSWFENAEEDLTDPV---RCNSLEEIKALREAHDAFR--SSLSSAQADFNQLAEL 2153

Query: 115  LLHDCDACATDAECDSIQQAT--------RNLDRRWRNICAMSMERRLKI-------EET 159
                      D +  S + A+          L+  WRN+  +  ER L++       EE 
Sbjct: 2154 ----------DRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN 2203

Query: 160  WRLWQKFLDDYSRFEDWLKSS 180
             +L Q+F    + F  W++ +
Sbjct: 2204 DKLRQEFAQHANAFHQWIQET 2224



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 64/299 (21%), Positives = 124/299 (41%), Gaps = 56/299 (18%)

Query: 127  ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
            E  S+    + ++  + ++  +  +R+  +E++ + +  F +  +  + W+  +E+ AA 
Sbjct: 1058 EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWI--NEKEAAL 1114

Query: 187  PSSS-GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE-------------- 231
             S   G      +   KKF+ FQ+ +    ++L+ INK    L  E              
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQE 1174

Query: 232  -------NRTDSAC-----SLKQMVH---------EGNQRWDNLQKRVTSILRRLKHFIG 270
                   + TDS       S + MVH         E N+RW +LQ+    +       +G
Sbjct: 1175 VYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ----LAEERSQLLG 1230

Query: 271  QREE---FETARDSILVWLTEMDLQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHNKI 325
               E   F    D    W+ E + Q  N +++      VQA  ++ + F+++++   +K+
Sbjct: 1231 SAHEVQRFHRDADETKEWIEEKN-QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKV 1289

Query: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 384
              +    E+LI+ S P  A  ++E+  EL +    +  R ++   KL       D HDL
Sbjct: 1290 NSLGETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKL------GDSHDL 1341



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 78/365 (21%), Positives = 143/365 (39%), Gaps = 38/365 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            EI+ +L +  + W+ L  L AAR ++L+E+L   QQ   N+     W+    + +A    
Sbjct: 1840 EIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDY 1898

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
             D+  +  IQ  L + +  + D   H   V  V    + L+        +   ++I    
Sbjct: 1899 GDTLAA--IQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK-----KNNHHEENISSKM 1951

Query: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP----SSSG 191
            + L+ +  ++   + +R+ K++E     Q F       E W+   E +          S 
Sbjct: 1952 KGLNGKVSDLEKAAAQRKAKLDENSAFLQ-FNWKADVVESWIGEKENSLKTDDYGRDLSS 2010

Query: 192  VIYTVAKEEL--KKFEAFQRQVHECLTQLE---LINKQYRRLARENRTDSACSLKQMVHE 246
            V   + K+E      +AFQ++    +T L+   L  K  +  A E R  S      ++  
Sbjct: 2011 VQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHAS------LMKR 2064

Query: 247  GNQRWDNLQKRVTSILRRLKHFIGQREEFET---ARDSILVWLTEMDLQLTNIEHFSECD 303
             +Q   N   R   +L    HF    + F T      +   W    +  LT+      C+
Sbjct: 2065 WSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP---VRCN 2121

Query: 304  VQAKIKQLK----AFQQEIS---LNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
               +IK L+    AF+  +S    + N++ ++  Q +     S P       E L+E  R
Sbjct: 2122 SLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWR 2180

Query: 357  YCQEV 361
              Q++
Sbjct: 2181 NLQKI 2185


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 145/747 (19%), Positives = 305/747 (40%), Gaps = 58/747 (7%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G++L   +H +K  E+  ++ +V   W+ LL+    +  KL+E     QQ ++N+  +  
Sbjct: 635  GQKLIDVNHYAK-DEVAARMNEVISLWKKLLEATELKGIKLREANQQ-QQFNRNVEDIEL 692

Query: 62   WLAHIESELAKPIV-YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            WL  +E  LA      D  N + +Q+K      L+ D+  H   +  +           D
Sbjct: 693  WLYEVEGHLASDDYGKDLTNVQNLQKK---HALLEADVAAHQDRIDGITIQARQFQ---D 746

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
            A   DAE  +I++    L  R+  +    + R+ K+ ++ RL Q F D     E W++  
Sbjct: 747  AGHFDAE--NIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE-ETWIREK 803

Query: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
            E  AA  ++ G      +  LKK +A Q ++     +++ + ++   +  E    +A  +
Sbjct: 804  EPIAA-STNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF-AAEDV 861

Query: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
            K  +HE NQ+W+ L+ + +   + L+  +  ++ F  A ++   W+ E +  + + ++  
Sbjct: 862  KAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA-ESWMREKEPIVGSTDYGK 920

Query: 301  ECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQ 359
            + D  +A +K+ +A   ++S   + I+ +  Q +   ++  P D    +E +  L  Y Q
Sbjct: 921  DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY-Q 979

Query: 360  EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 419
            E   R     K  I   L     D    ++E+ D         + +  D   S    + L
Sbjct: 980  EKSPREVTMKKGDILTLLNSTNKDW--WKVEVNDRQGFVPAA-YVKKLDPAQSASRENLL 1036

Query: 420  SLSLAQPLRSERSGRDTPASVD--SIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKD 477
                +  LR E+    T  + +  S+ L      +L   L          E  +G  +K 
Sbjct: 1037 EEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLEL------GEKRKGMLEKS 1090

Query: 478  FYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQT 537
                       ++  E+ E    + E     TS +  A   Q+  L K  DD +  ++  
Sbjct: 1091 C-------KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKAN 1143

Query: 538  ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE-----------HKLKEEEESL 586
            E+ ++       +L++         G  +  + +V++ E            K     +S 
Sbjct: 1144 ESRLKDINKVAEDLESE--------GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195

Query: 587  PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 646
               V+  +T      + +RW  LQ Q   +  ++  +  + Q+F+ D +    W+   EE
Sbjct: 1196 RLMVHTVATFNSIKELNERWRSLQ-QLAEERSQLLGSAHEVQRFHRDADETKEWI---EE 1251

Query: 647  ELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQ 706
            + + L       D+ +++   +K +  ++ +      + S+   +    Q+  + + DLQ
Sbjct: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQ 1311

Query: 707  DRLSQMNGRWDRVCSLLEEWRGLLQDA 733
            ++ +++N  W  +    ++ +  L D+
Sbjct: 1312 EKCTELNQAWSSLGKRADQRKAKLGDS 1338



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 136/737 (18%), Positives = 297/737 (40%), Gaps = 100/737 (13%)

Query: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
            ++ +L  + D+WQ L+   A + +KLKE     Q  +  +     WL+ +E+ LA     
Sbjct: 1634 VKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYG 1692

Query: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                S  +   L + Q L+ DI  H   +  + +  + L+      ++  +   ++    
Sbjct: 1693 KDLAS--VNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-----TSSAFDTSQVKDKRD 1745

Query: 137  NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
             ++ R++ I +M+  RR K+ E+ RL Q F  D    E W+K  ++        G   T 
Sbjct: 1746 TINGRFQKIKSMAASRRAKLNESHRLHQ-FFRDMDDEESWIK-EKKLLVGSEDYGRDLTG 1803

Query: 197  AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 256
             +   KK +  + ++      ++ +    ++L+ +N T     ++Q + +  + W  L++
Sbjct: 1804 VQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN-TIGKEEIQQRLAQFVEHWKELKQ 1862

Query: 257  RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAKIKQLKAF 314
               +  +RL+  + + ++F    +    W+ E  + L   E + +    +Q  +K+ +AF
Sbjct: 1863 LAAARGQRLEESL-EYQQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAF 1920

Query: 315  QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR 374
            + + +++ +++  +   G+ LI+K+                 + + +  +++  + K   
Sbjct: 1921 ETDFTVHKDRVNDVCTNGQDLIKKN---------------NHHEENISSKMKGLNGK--- 1962

Query: 375  LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR 434
              + D E   + R+ +L++++A    +W     +S +  + +S         L+++  GR
Sbjct: 1963 --VSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS---------LKTDDYGR 2011

Query: 435  DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 494
            D  +    +  +   D  L    +  ++     +D+         L  A  +    I   
Sbjct: 2012 DLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQ---------LLAAKHVQSKAIEAR 2062

Query: 495  PEAYVKLTENAIKNTSGDHSAL---ESQIRQ-----LGKALDDSRFQIQQTENIIRSKT- 545
              + +K     + N++     L   +S  R+     L  A   S F     EN     T 
Sbjct: 2063 HASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFN-SWFENAEEDLTD 2121

Query: 546  PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF---VNLHSTETQTAGV 602
            P         K   +      SS+ S +   ++L E +  +  F    N ++  T  A +
Sbjct: 2122 PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEA-L 2180

Query: 603  IDRWELLQAQALSKEL-------RMKQNLQKWQQFNSDLNSIWAWLGDT----------- 644
             + W  LQ     +EL       R ++N +  Q+F    N+   W+ +T           
Sbjct: 2181 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMV 2240

Query: 645  ------EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
                  E +LE  +R     +I+ +  Q+KK+++L  A++  +A+IL       ++T+  
Sbjct: 2241 EESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAME--EALIL-----DNKYTEHS 2291

Query: 699  SKESRDLQDRLSQMNGR 715
            +       D+L Q+  R
Sbjct: 2292 TVGLAQQWDQLDQLGMR 2308



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 163/893 (18%), Positives = 349/893 (39%), Gaps = 118/893 (13%)

Query: 6    AKASHESKASE--IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 63
            AK   E    E  I+ K  +VN  WQ L  L   R  KL      VQ+ ++++    +W+
Sbjct: 213  AKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWI 271

Query: 64   AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 123
               E  +A         S++  R L   Q L R  E     +A++ +  + L  + D   
Sbjct: 272  KEKEQLMA---------SDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQ 322

Query: 124  TD--AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
                     IQ     L   W  I  ++ ER  ++ +++RL Q+FL D+     W+   +
Sbjct: 323  QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL-QRFLADFRDLTSWVTEMK 381

Query: 182  RTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
               A  ++  +   VA  E  L + +  + ++                 A E+   SA  
Sbjct: 382  ---ALINADELASDVAGAEALLDRHQEHKGEID----------------AHEDSFKSADE 422

Query: 240  LKQ-MVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILV---------W 285
              Q ++  G+   D +++++T +       L+ +  +R+++E   D  L          W
Sbjct: 423  SGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNW 482

Query: 286  LTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA 344
            +++ +  L N +     D V+A +K+ + F++ +S    KI  +     +LI+ +     
Sbjct: 483  MSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH---- 538

Query: 345  AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHD 404
                  ++++      +  R    H++ +R            R  +L DS  L       
Sbjct: 539  ----YAMEDVATRRDALLSRRNALHERAMR------------RRAQLADSFHLQQFF--- 579

Query: 405  RSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRA 464
            R +D L S   +  +  +  +  +   + +       +   E   +      LE A  + 
Sbjct: 580  RDSDELKS-WVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKA-GQK 637

Query: 465  LPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLG 524
            L   +   +D+    +   + L   ++  +    +KL E              +Q +Q  
Sbjct: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE-------------ANQQQQFN 684

Query: 525  KALDDSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKLLGECSSSIDSVKRLEHKLKE 581
            + ++D    + + E  + S    G +L       K +  L  + ++  D +  +  + ++
Sbjct: 685  RNVEDIELWLYEVEGHLASDD-YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQ 743

Query: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 641
             +++  G  +  + + +   ++ R+E L+   ++++ ++  +L+  Q F  D+     W+
Sbjct: 744  FQDA--GHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWI 800

Query: 642  GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 701
             + E       R     D+  ++  +KK + LQ  +   +  I ++        +     
Sbjct: 801  REKEPIAASTNR---GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA 857

Query: 702  SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 761
            + D++ +L ++N +W+ + +   + R  L+D+L   Q F + +     M E         
Sbjct: 858  AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK-------- 909

Query: 762  VPIDSNLDAEILQDHHKQLMQIKHELLESQL-----RVASLQDMSCQLLVNAEGTDCLEA 816
             PI  + D    +D  + L++ KHE L S L      + +L++ +         TD    
Sbjct: 910  EPIVGSTDYGKDEDSAEALLK-KHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968

Query: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSV 869
            KE V  + +  +   +EV+  +K+ + L  ++S+ +D   W   +  D  G V
Sbjct: 969  KELVLALYDYQEKSPREVT--MKKGDILTLLNSTNKD---WWKVEVNDRQGFV 1016



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 141/749 (18%), Positives = 293/749 (39%), Gaps = 88/749 (11%)

Query: 129 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 188
           + IQ+  + +  R+     +S  RR K+E+++R +Q F  D    E W++   + A+  +
Sbjct: 13  EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDEN 71

Query: 189 SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 248
                 T  + +L+K +AF+ +V      +  +++    +  E    S  +++  + E +
Sbjct: 72  YKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE-TIRTRLMELH 128

Query: 249 QRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDLQLTNIEHFSECD-VQA 306
           ++W+ L +++    + +K    Q+  ++    + ++ W+ + +  +T+ E   + + V+ 
Sbjct: 129 RQWELLLEKMRE--KGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEV 186

Query: 307 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 366
             K+ + FQ +++ +  ++ ++     +LI++  P +  +I+ + DE+    Q + G   
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLKGLAL 245

Query: 367 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 426
           +   KL                         +++   +R  D  +S            Q 
Sbjct: 246 QRQGKLF----------------------GAAEVQRFNRDVDETISWIKEKE------QL 277

Query: 427 LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAV 484
           + S+  GRD  ASV ++  + +    L RDL +     +AL +E +         L+ + 
Sbjct: 278 MASDDFGRDL-ASVQALLRKHE---GLERDLAALEDKVKALCAEADR--------LQQSH 325

Query: 485 GLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544
            LS   I    E  +   E      +  H+ L    R L + L D R     T  +   K
Sbjct: 326 PLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQRFLADFR---DLTSWVTEMK 381

Query: 545 T-PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV------------N 591
                 EL +   G   LL         +   E   K  +ES    +             
Sbjct: 382 ALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREK 441

Query: 592 LHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 651
           L     + A +++ WEL + Q         +     Q F  D   +  W+   E     L
Sbjct: 442 LTVLSEERAALLELWELRRQQ--------YEQCMDLQLFYRDTEQVDNWMSKQE---AFL 490

Query: 652 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 711
              +L   + ++E  +KK ++ +K++  ++  I +++  + +  Q +     D+  R   
Sbjct: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550

Query: 712 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 771
           +  R + +       R  L D+    Q F +       + E +    +E     SNL  +
Sbjct: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK 610

Query: 772 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLL 830
           + Q H       + EL  +Q R+ +L+    +L+ VN    D + A+    VI    KLL
Sbjct: 611 V-QKH----QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN-EVISLWKKLL 664

Query: 831 LKEVSRHIK--ELEKLLDVSSSQQDLSSW 857
                + IK  E  +    + + +D+  W
Sbjct: 665 EATELKGIKLREANQQQQFNRNVEDIELW 693



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 162/873 (18%), Positives = 340/873 (38%), Gaps = 102/873 (11%)

Query: 14  ASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
           ASE I  +L +++ +W+ LL+ +  +  KL +    VQ L +    +  W+   E+ +  
Sbjct: 116 ASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL-RECEDVMDWINDKEAIVT- 173

Query: 73  PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVAS-------VLNLCEVLLHDCDACATD 125
                   SEE+ + L   + LQ+  E+  T +A+       V      L+ +       
Sbjct: 174 --------SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE-----QH 220

Query: 126 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 185
            E + I+     ++  W+ +  ++++R+ K+     + Q+F  D      W+K  E+  A
Sbjct: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMA 279

Query: 186 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 245
                  + +V +  L+K E  +R +     +++ +  +  RL +++   SA  ++    
Sbjct: 280 SDDFGRDLASV-QALLRKHEGLERDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKRE 337

Query: 246 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE-CDV 304
           E    W+ ++        RL      +      RD +  W+TEM   +   E  S+    
Sbjct: 338 ELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD-LTSWVTEMKALINADELASDVAGA 396

Query: 305 QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE--ELDELRRYCQEVF 362
           +A + + +  + EI  + +  +     G+ L+         + E+   L E R    E++
Sbjct: 397 EALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELW 456

Query: 363 GRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS-DLHWHDRSADSLLSPQPSSNLSL 421
               + +++ + L L   + +  D  +  +++  L+ DL     S ++LL        SL
Sbjct: 457 ELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL 516

Query: 422 SLAQPLRSERSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSRALPSED----EEGQD 474
           S  +        + T     +  L  ++ Y   D++   ++ +SR     +       Q 
Sbjct: 517 SAQEE-------KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569

Query: 475 DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQI 534
              F+L+     SD +     E     T+ A K    D S L+      GK      F+ 
Sbjct: 570 ADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK----DPSNLQ------GKVQKHQAFEA 619

Query: 535 QQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS 594
           + + N  R        +D   K   KL+            + H  K+E            
Sbjct: 620 ELSANQSR--------IDALEKAGQKLID-----------VNHYAKDE------------ 648

Query: 595 TETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL 654
              +   VI  W+ L      K +++++  Q+ QQFN ++  I  WL + E  L      
Sbjct: 649 VAARMNEVISLWKKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEGHLASDDYG 707

Query: 655 ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNG 714
           +  T++Q ++   KK   L+  V   +  I  I + + +F  A   ++ +++ +   +  
Sbjct: 708 KDLTNVQNLQ---KKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVA 764

Query: 715 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL- 773
           R++ +   +   +  L D+L   Q F ++        E    R+ E +   +N   +++ 
Sbjct: 765 RYEALKEPMVARKQKLADSLRLQQLFRDVED------EETWIREKEPIAASTNRGKDLIG 818

Query: 774 -QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLK 832
            Q+  K+   ++ E+   + R+ ++       +V        + K K+H +  + + L  
Sbjct: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKG-NAMVEEGHFAAEDVKAKLHELNQKWEALKA 877

Query: 833 EVSRHIKELEKLLDVS---SSQQDLSSWSSADE 862
           + S+  ++LE  L      +   +  SW    E
Sbjct: 878 KASQRRQDLEDSLQAQQYFADANEAESWMREKE 910



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 167/916 (18%), Positives = 353/916 (38%), Gaps = 138/916 (15%)

Query: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
            ERL + SH   A +++ K  ++N  W  L      R  KL ++   +Q+   +   L +W
Sbjct: 1297 ERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH-DLQRFLSDFRDLMSW 1354

Query: 63   LAHIES-----ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 117
            +  I       ELAK    D   +E +   L   QE + +I+  +    +     + LL 
Sbjct: 1355 INGIRGLVSSDELAK----DVTGAEAL---LERHQEHRTEIDARAGTFQAFEQFGQQLLA 1407

Query: 118  DCDACATDAE--CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 175
                 + + +   D + Q   +L++ W       ++RR+ +++   L Q F  D  + E+
Sbjct: 1408 HGHYASPEIKQKLDILDQERADLEKAW-------VQRRMMLDQCLEL-QLFHRDCEQAEN 1459

Query: 176  WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH---ECLTQLELINKQYRRLAREN 232
            W+ + E           + +V +  +KK E F + ++   E +  L+    Q        
Sbjct: 1460 WMAAREAFLNTEDKGDSLDSV-EALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA 1518

Query: 233  RTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDL 291
            + D +    +++     RW  L+ ++  I +R K    Q  ++F    D I  W++E  L
Sbjct: 1519 KGDISSRRNEVL----DRWRRLKAQM--IEKRSKLGESQTLQQFSRDVDEIEAWISEK-L 1571

Query: 292  QLTNIEHFSE------CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK-----SE 340
            Q  + E + +        + +K ++ +AF+ E+  N ++I  +I  G  LIE+     SE
Sbjct: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1631

Query: 341  PLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDL 400
                A +    D+ +   Q+   + ++                L +   +   +  + D 
Sbjct: 1632 DAVKARLAALADQWQFLVQKSAEKSQK----------------LKEANKQQNFNTGIKDF 1675

Query: 401  HWHDRSADSLLSPQ------PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS 454
             +     ++LL+ +       S N  L   Q L ++ S  +            D   DL+
Sbjct: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE------------DRLKDLN 1723

Query: 455  RDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHS 514
               +S M+ +  + D     DK   + G       M   +     KL E+          
Sbjct: 1724 SQADSLMTSS--AFDTSQVKDKRDTINGRFQKIKSM---AASRRAKLNES---------- 1768

Query: 515  ALESQIRQLGKALDDSRFQIQQTENIIRS----KTPTGPE-LDTSYKGYMKLLGECSSSI 569
                ++ Q  + +DD    I++ + ++ S    +  TG + L   +K     L     +I
Sbjct: 1769 ---HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI 1825

Query: 570  DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 629
              V     KL ++       +     + + A  ++ W+ L+  A ++  R++++L+ +QQ
Sbjct: 1826 QGVLDTGKKLSDDNT-----IGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLE-YQQ 1879

Query: 630  FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 689
            F +++    AW+    E++  +   +    +  I+  +KK +  +      K  +  +  
Sbjct: 1880 FVANVEEEEAWI---NEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCT 1936

Query: 690  CSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 749
               +  + ++    ++  ++  +NG+     S LE+     +  L +   F + +    +
Sbjct: 1937 NGQDLIKKNNHHEENISSKMKGLNGK----VSDLEKAAAQRKAKLDENSAFLQFNWKADV 1992

Query: 750  MLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR------VASLQDMSCQ 803
            +   I  ++N +   D   D   +     Q +  K E  ++ L+      +A++  +  Q
Sbjct: 1993 VESWIGEKENSLKTDDYGRDLSSV-----QTLLTKQETFDAGLQAFQQEGIANITALKDQ 2047

Query: 804  LL---------VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL-LDVSSSQQD 853
            LL         + A     ++   ++       K  L E   H +++E L L  +     
Sbjct: 2048 LLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107

Query: 854  LSSWSSADELDTSGSV 869
             +SW    E D +  V
Sbjct: 2108 FNSWFENAEEDLTDPV 2123



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 53/201 (26%), Positives = 85/201 (42%), Gaps = 40/201 (19%)

Query: 3    ERLAKASH-ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD-------K 54
            ++L  A H +SKA  IE +   +  RW  LL   AAR KKL E     ++++       K
Sbjct: 2046 DQLLAAKHVQSKA--IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103

Query: 55   NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 114
              S+  +W  + E +L  P+    CNS E  + L E  +  R     S+  A    L E+
Sbjct: 2104 KASAFNSWFENAEEDLTDPV---RCNSLEEIKALREAHDAFR--SSLSSAQADFNQLAEL 2158

Query: 115  LLHDCDACATDAECDSIQQAT--------RNLDRRWRNICAMSMERRLKI-------EET 159
                      D +  S + A+          L+  WRN+  +  ER L++       EE 
Sbjct: 2159 ----------DRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN 2208

Query: 160  WRLWQKFLDDYSRFEDWLKSS 180
             +L Q+F    + F  W++ +
Sbjct: 2209 DKLRQEFAQHANAFHQWIQET 2229



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 64/299 (21%), Positives = 124/299 (41%), Gaps = 56/299 (18%)

Query: 127  ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 186
            E  S+    + ++  + ++  +  +R+  +E++ + +  F +  +  + W+  +E+ AA 
Sbjct: 1058 EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWI--NEKEAAL 1114

Query: 187  PSSS-GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE-------------- 231
             S   G      +   KKF+ FQ+ +    ++L+ INK    L  E              
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQE 1174

Query: 232  -------NRTDSAC-----SLKQMVH---------EGNQRWDNLQKRVTSILRRLKHFIG 270
                   + TDS       S + MVH         E N+RW +LQ+    +       +G
Sbjct: 1175 VYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ----LAEERSQLLG 1230

Query: 271  QREE---FETARDSILVWLTEMDLQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHNKI 325
               E   F    D    W+ E + Q  N +++      VQA  ++ + F+++++   +K+
Sbjct: 1231 SAHEVQRFHRDADETKEWIEEKN-QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKV 1289

Query: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 384
              +    E+LI+ S P  A  ++E+  EL +    +  R ++   KL       D HDL
Sbjct: 1290 NSLGETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKL------GDSHDL 1341



 Score = 35.8 bits (81), Expect = 0.20
 Identities = 78/365 (21%), Positives = 143/365 (39%), Gaps = 38/365 (10%)

Query: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
            EI+ +L +  + W+ L  L AAR ++L+E+L   QQ   N+     W+    + +A    
Sbjct: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDY 1903

Query: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
             D+  +  IQ  L + +  + D   H   V  V    + L+        +   ++I    
Sbjct: 1904 GDTLAA--IQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK-----KNNHHEENISSKM 1956

Query: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP----SSSG 191
            + L+ +  ++   + +R+ K++E     Q F       E W+   E +          S 
Sbjct: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQ-FNWKADVVESWIGEKENSLKTDDYGRDLSS 2015

Query: 192  VIYTVAKEEL--KKFEAFQRQVHECLTQLE---LINKQYRRLARENRTDSACSLKQMVHE 246
            V   + K+E      +AFQ++    +T L+   L  K  +  A E R  S      ++  
Sbjct: 2016 VQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHAS------LMKR 2069

Query: 247  GNQRWDNLQKRVTSILRRLKHFIGQREEFET---ARDSILVWLTEMDLQLTNIEHFSECD 303
             +Q   N   R   +L    HF    + F T      +   W    +  LT+      C+
Sbjct: 2070 WSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP---VRCN 2126

Query: 304  VQAKIKQLK----AFQQEIS---LNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
               +IK L+    AF+  +S    + N++ ++  Q +     S P       E L+E  R
Sbjct: 2127 SLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWR 2185

Query: 357  YCQEV 361
              Q++
Sbjct: 2186 NLQKI 2190


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 166/768 (21%), Positives = 300/768 (39%), Gaps = 133/768 (17%)

Query: 8    ASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE 67
            A H ++A  I  +L +V   W+ L   +  R + L E    +Q   +++   + WL   +
Sbjct: 1027 AGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQ 1085

Query: 68   SELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAE 127
            + +A           E +  L +   L+ ++E+  +  + +  L E +  D      D +
Sbjct: 1086 TAVASE--EGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRD----QADPQ 1139

Query: 128  CDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFP 187
            C  ++Q    L   W  +  M   R+ ++ +    +Q FL D  + E  L S E   +  
Sbjct: 1140 CLFLRQRLEALGTGWEELGRMWESRQGRLAQAHG-FQGFLRDARQAEGVLSSQEYVLSHT 1198

Query: 188  SSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEG 247
               G +   A   +KK E F       ++ ++   ++   L    R        Q+V EG
Sbjct: 1199 EMPGTLQA-ADAAIKKLEDF-------MSTMDANGERIHGLLEAGR--------QLVSEG 1242

Query: 248  NQRWDNLQKRVTSILRRLK-------HFIGQ----REEFETARD--SILVWLTEMDLQLT 294
            N   D ++++  SI RR K        F+G+    RE+    +D   + +W+ E  L   
Sbjct: 1243 NIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQ 1302

Query: 295  NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL-IEKSEPLDAAIIEEELDE 353
            ++ +    ++  K ++ +AF  E++ N + ++++  +G +L +EK E    A++ E+L +
Sbjct: 1303 DVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPEL--KALVSEKLRD 1360

Query: 354  LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--------SDLHWHDR 405
            L R   E+    +   + L          D +  EL  +   AL        + LH  D 
Sbjct: 1361 LHRRWDELETTTQAKARSLF---------DANRAELFAQSCCALESWLESLQAQLHSDDY 1411

Query: 406  SADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRAL 465
              D       S N+ L   Q L  E + R+    V++I                A ++AL
Sbjct: 1412 GKD-----LTSVNILLKKQQMLEWEMAVRE--KEVEAI---------------QAQAKAL 1449

Query: 466  PSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK 525
              ED+   +                        V+ T  A++       AL   +R+  +
Sbjct: 1450 AQEDQGAGE------------------------VERTSRAVEE---KFRALCQPMRERCR 1482

Query: 526  ALDDSRFQIQ---QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK---- 578
             L  SR Q Q     E+ I   T   P   +   G           + SV+ L  K    
Sbjct: 1483 RLQASREQHQFHRDVEDEILWVTERLPMASSMEHG---------KDLPSVQLLMKKNQTL 1533

Query: 579  LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK------ELRMK--QNLQKWQQF 630
             KE +   P   +L   +          EL + Q + K      ELR K  ++  + QQF
Sbjct: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593

Query: 631  NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 690
              D     AW+G  E+EL  + + E + D  + + ++KK + L++A+      I  +   
Sbjct: 1594 YRDAAEAEAWMG--EQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAAS 1650

Query: 691  SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 738
            S +    +  ES  +  R +Q++  +  +  L  E R  LQ+ L  CQ
Sbjct: 1651 SQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQ 1698



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 176/884 (19%), Positives = 327/884 (36%), Gaps = 103/884 (11%)

Query: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
            + E+L KA+   K   I     ++N RWQ    L   +   L   L ++Q      +  +
Sbjct: 914  IAEQLLKANPPGK-DRIVNTQEQLNHRWQQFRRLADGKKAALTSAL-SIQNYHLECTETQ 971

Query: 61   TWLAHIES--ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 118
             W+       E  + +  D      +QRKL      +RD+E  +  V  +      L   
Sbjct: 972  AWMREKTKVIESTQGLGNDLAGVLALQRKL---AGTERDLEAIAARVGELTREANAL--- 1025

Query: 119  CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLK 178
              A    A+  +I    R +   W ++ A    R   + E  RL Q FL     F+ WL 
Sbjct: 1026 --AAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL-QDFLRSLDDFQAWLG 1082

Query: 179  SSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
             ++ TA            A+  L +  A + +V    ++   +      + R+       
Sbjct: 1083 RTQ-TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCL 1141

Query: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH 298
             L+Q +      W+ L +   S   RL    G +     AR +  V L+  +  L++ E 
Sbjct: 1142 FLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGV-LSSQEYVLSHTEM 1200

Query: 299  FSECDV-QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 357
                    A IK+L+ F   +  N  +I  ++  G QL+ +   + A  I E+ D + R 
Sbjct: 1201 PGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGN-IHADKIREKADSIERR 1259

Query: 358  CQEVFGRVERYHKKLIRLPLPDDEHDLSD-RELELEDSAALSDLHWHDRSADSLLSPQPS 416
             ++     +++  +L      + +H L D  EL+L          W D   + +L+ Q  
Sbjct: 1260 HKKNQDAAQQFLGRL--RDNREQQHFLQDCHELKL----------WID---EKMLTAQ-- 1302

Query: 417  SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 476
             ++S   A+ L ++                W        +L +A    L   D+EG++  
Sbjct: 1303 -DVSYDEARNLHTK----------------WQKHQAFMAEL-AANKDWLDKVDKEGRE-- 1342

Query: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKAL-DDSRFQIQ 535
                         +  E PE    ++E  +++       LE+  +   ++L D +R ++ 
Sbjct: 1343 -------------LTLEKPELKALVSEK-LRDLHRRWDELETTTQAKARSLFDANRAELF 1388

Query: 536  QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNL 592
                          +       Y K L   +  +   + LE ++   ++E E++      
Sbjct: 1389 AQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKA 1448

Query: 593  HSTETQTAGVIDRW-----ELLQA--QALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 645
             + E Q AG ++R      E  +A  Q + +  R  Q  ++  QF+ D+     W+    
Sbjct: 1449 LAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWV---T 1505

Query: 646  EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 705
            E L     +E   D+ +++L +KK + LQK +   +  I  +        +  +  +   
Sbjct: 1506 ERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR------ERQRALGAAAA 1559

Query: 706  QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE------NIDRRKN 759
               L+++   W R+   LE     L+DAL   Q + + +     M E        ++ K+
Sbjct: 1560 GPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619

Query: 760  EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 819
            E+         ++L+       Q  H+L       AS QDM      + E T     + +
Sbjct: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQL------AASSQDMIDH--EHPESTRISIRQAQ 1671

Query: 820  VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
            V  +   LK L  E    ++E  +L  +     DL  W    E+
Sbjct: 1672 VDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREV 1715



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 76/354 (21%), Positives = 144/354 (40%), Gaps = 51/354 (14%)

Query: 3   ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
           E  A+  H+ K   I  +   V   W  L  ++AAR ++L   L  +Q++ +++  L  W
Sbjct: 490 ELAAERYHDIK--RIAARQHNVARLWDFLRQMVAARRERLLLNL-ELQKVFQDLLYLMDW 546

Query: 63  LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD---- 118
           +                  EE++ +L  Q     D+ +H  GV  +L L E++  D    
Sbjct: 547 M------------------EEMKGRLQSQ-----DLGRHLAGVEDLLQLHELVEADIAVQ 583

Query: 119 --------------CDACATDAECDS--IQQATRNLDRRWRNICAMSMERRLKIEETWRL 162
                         C+       CD   + +    L++ +  +C ++  RR ++EE+ RL
Sbjct: 584 AERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRL 643

Query: 163 WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELIN 222
           W +FL +    E W++  +   A  + +G   T A   L K  A + ++   L  L+L  
Sbjct: 644 W-RFLWEVGEAEAWVREQQHLLA-SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701

Query: 223 KQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSI 282
           +Q ++L  E     A        E   +W+ L+       +RL        +F+   + +
Sbjct: 702 EQGQQLVAEGH-PGASQASARAAELQAQWERLEALAEERAQRLAQ-AASLYQFQADANDM 759

Query: 283 LVWLTEMDLQLTNIE-HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 335
             WL +    +++ E    E   QA  +Q +A ++EI  +   ++ +  Q   L
Sbjct: 760 EAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 113/636 (17%), Positives = 244/636 (38%), Gaps = 96/636 (15%)

Query: 137 NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF-------EDWLKSSERTAAFPSS 189
           ++++ W  +     ER L +       +K     +RF       E WL  ++R  +   +
Sbjct: 394 DINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVS-QDN 452

Query: 190 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 249
            G+     +  ++K EA +  +     +++ ++     LA E   D    +    H   +
Sbjct: 453 FGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIK-RIAARQHNVAR 511

Query: 250 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE---HFSECDVQA 306
            WD L++ V +   RL   +  ++ F+     ++ W+ EM  +L + +   H +  +   
Sbjct: 512 LWDFLRQMVAARRERLLLNLELQKVFQDLL-YLMDWMEEMKGRLQSQDLGRHLAGVEDLL 570

Query: 307 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSE---PLDAAIIEEELDELRR----YCQ 359
           ++ +L   + +I++   ++  + A   +     +   P D  ++ E + +L +     C+
Sbjct: 571 QLHEL--VEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCE 628

Query: 360 EVFGRVERYH--KKLIRLP---------LPDDEHDLSDRELELEDSAALSDLHWHDRSAD 408
               R  R    ++L R           + + +H L+  +   + + AL  L+ H     
Sbjct: 629 LAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRG 688

Query: 409 SLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE--WDHDYDLSRDLESAMSRALP 466
            +        L+L   Q L +E     + AS  +  L+  W+    L+ +    +++A  
Sbjct: 689 EMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS 748

Query: 467 S-EDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK 525
             + +   +D + +L  A+ L       SPE  +   E + +  +  H ALE +IR    
Sbjct: 749 LYQFQADANDMEAWLVDALRLVS-----SPE--LGHDEFSTQALARQHRALEEEIRSHRP 801

Query: 526 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 585
            LD  R Q       + S+TP                 E    + +++R           
Sbjct: 802 TLDALREQAAALPPTL-SRTP-----------------EVQGRVPTLER----------- 832

Query: 586 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 645
                               +E LQA+A  +   ++  L  +    S+  +   W+   E
Sbjct: 833 -------------------HYEELQARAGERARALEAALALYTML-SEAGACGLWV---E 869

Query: 646 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 705
           E+ + L  L L   ++ +E+  ++ + L+  ++   A I ++N  + +  +A+      +
Sbjct: 870 EKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRI 929

Query: 706 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 741
            +   Q+N RW +   L +  +  L  AL   Q +H
Sbjct: 930 VNTQEQLNHRWQQFRRLADGKKAALTSAL-SIQNYH 964



 Score = 34.3 bits (77), Expect = 0.59
 Identities = 57/253 (22%), Positives = 95/253 (37%), Gaps = 47/253 (18%)

Query: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
            G RL KA    KA EI   +  V + W  L    AAR + L +T     +  K +  L  
Sbjct: 1863 GHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELML 1921

Query: 62   WLAHIESEL-AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
            W+  +  ++ A+    D  +++ +   +  QQ ++ +IE  +   +S +++ + LL    
Sbjct: 1922 WMDEVNLQMDAQERPRDVSSADLV---IKNQQGIKAEIEARADRFSSCIDMGKELL---- 1974

Query: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLD------------ 168
               +    + I +    L  R               +ET   WQ+ +D            
Sbjct: 1975 -ARSHYAAEEISEKLSQLQAR--------------RQETAEKWQEKMDWLQLVLEVLVFG 2019

Query: 169  -DYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQ---------VHECLTQL 218
             D    E WL S E      +  G      +  +K+ EAFQ+            E LT L
Sbjct: 2020 RDAGMAEAWLCSQEPLVR-SAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078

Query: 219  ELINKQYRRLARE 231
            E   K+ +R   E
Sbjct: 2079 EEREKERKRKREE 2091



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 54/254 (21%), Positives = 108/254 (42%), Gaps = 14/254 (5%)

Query: 561 LLGECSSSIDSVK-RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
           L GE S  +  +K  LE   +   E  PG         + A +  +WE L+A A  +  R
Sbjct: 686 LRGEMSGRLGPLKLTLEQGQQLVAEGHPG---ASQASARAAELQAQWERLEALAEERAQR 742

Query: 620 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 679
           + Q    +Q F +D N + AWL D    L  +   EL  D  + +   ++ + L++ +  
Sbjct: 743 LAQAASLYQ-FQADANDMEAWLVDA---LRLVSSPELGHDEFSTQALARQHRALEEEIRS 798

Query: 680 RKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG 739
            +  + ++   +       S+ + ++Q R+  +   ++ + +   E    L+ AL     
Sbjct: 799 HRPTLDALREQAAALPPTLSR-TPEVQGRVPTLERHYEELQARAGERARALEAALALYTM 857

Query: 740 FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQD 799
             E +    L +E  ++  N +   +   D E++Q   + L   + E+     ++ ++ D
Sbjct: 858 LSE-AGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETL---EPEMNTLAAQITAVND 913

Query: 800 MSCQLL-VNAEGTD 812
           ++ QLL  N  G D
Sbjct: 914 IAEQLLKANPPGKD 927


>gi|5032307 dystrophin Dp140c isoform [Homo sapiens]
          Length = 1105

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7   KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
           K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 80  KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 60  RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
           R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 140 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 120 DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 192 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 180 SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
           +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 248 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 229 ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
            R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 288 EMDLQLT 294
             D +L+
Sbjct: 363 LKDDELS 369



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 102/567 (17%), Positives = 222/567 (39%), Gaps = 74/567 (13%)

Query: 274 EFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 331
           +F  A   +  WL+ +D  ++   +      D+   I + KA  Q++     ++E++I  
Sbjct: 14  DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 73

Query: 332 GEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 390
            + L  K+   +A  II + ++ ++    EV   ++   ++L  +     +   +  E E
Sbjct: 74  AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 133

Query: 391 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 450
                A + L        ++ + Q     +  LA+ LR                 +W  +
Sbjct: 134 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-----------------QWQTN 176

Query: 451 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTS 510
            D++ DL   + R     D    D +  +          MI E+  A  +      K  S
Sbjct: 177 VDVANDLALKLLR-----DYSADDTRKVH----------MITENINASWRSIH---KRVS 218

Query: 511 GDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGPELDTS------YKGY 558
              +ALE   R L +  LD  +F     + + T N+++  T     L+ S       K +
Sbjct: 219 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 278

Query: 559 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
             L GE  +  D    L+   ++   SL G  +    + +   +  +W  L+ ++L+   
Sbjct: 279 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 338

Query: 619 RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 678
            ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   ++ Q    +  ++ + 
Sbjct: 339 HLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELK 396

Query: 679 HRKAIILSINLCSPEFTQADSKE---------------------SRDLQDRLSQMNGRWD 717
            ++ +I+S       F      E                     +R L+ +  ++N  W+
Sbjct: 397 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 456

Query: 718 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 777
           ++     +W+  + + L + Q   E +  L L L   +  K    P+  +L  + LQDH 
Sbjct: 457 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHL 515

Query: 778 KQLMQIKHELLESQLRVASLQDMSCQL 804
           +++  ++ E+   +  V+ + D++ QL
Sbjct: 516 EKVKALRGEIAPLKENVSHVNDLARQL 542



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 57/301 (18%), Positives = 121/301 (40%), Gaps = 39/301 (12%)

Query: 24  VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 83
           +N  W+ +   ++ R   L+ET   +QQ   ++     WL   E+E    ++ D+   E 
Sbjct: 206 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETTANVLQDATRKER 263

Query: 84  -------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                  ++  + + Q+LQ +IE H+    ++    + +L   +  + DA    +Q+   
Sbjct: 264 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SDDAVL--LQRRLD 320

Query: 137 NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
           N++ +W  +   S+  R  +E +   W++          WL+  +   +  +  G  +  
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 197 AKEELKKFEAFQRQV-------------------HECLTQLELINKQYRRLARENRTDSA 237
            +++     AF+R++                    + L  LE + ++ R L  E R  + 
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 440

Query: 238 CS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
              L++   E N  W+ L        R++   + + +E + A D       E+DL+L   
Sbjct: 441 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD-------ELDLKLRQA 493

Query: 297 E 297
           E
Sbjct: 494 E 494


>gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]
          Length = 1133

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 36/307 (11%)

Query: 7   KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLV-------AVQQLDKNMSSL 59
           K S++   + I  ++ ++ ++W  + + +  R ++L E L        A ++ ++ +   
Sbjct: 80  KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQA 139

Query: 60  RTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 119
           R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    +L   LL D 
Sbjct: 140 R---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 191

Query: 120 DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
            A  T      +   T N++  WR+I     ER   +EET RL Q+F  D  +F  WL  
Sbjct: 192 SADDTR----KVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 247

Query: 180 SERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 228
           +E TA               S GV     KE +K+++  Q ++         +++  +++
Sbjct: 248 AETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVYHNLDENSQKI 302

Query: 229 ARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 287
            R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    +   +LVWL 
Sbjct: 303 LRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 362

Query: 288 EMDLQLT 294
             D +L+
Sbjct: 363 LKDDELS 369



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 102/567 (17%), Positives = 222/567 (39%), Gaps = 74/567 (13%)

Query: 274 EFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 331
           +F  A   +  WL+ +D  ++   +      D+   I + KA  Q++     ++E++I  
Sbjct: 14  DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 73

Query: 332 GEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 390
            + L  K+   +A  II + ++ ++    EV   ++   ++L  +     +   +  E E
Sbjct: 74  AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 133

Query: 391 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 450
                A + L        ++ + Q     +  LA+ LR                 +W  +
Sbjct: 134 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-----------------QWQTN 176

Query: 451 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTS 510
            D++ DL   + R     D    D +  +          MI E+  A  +      K  S
Sbjct: 177 VDVANDLALKLLR-----DYSADDTRKVH----------MITENINASWRSIH---KRVS 218

Query: 511 GDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTGPELDTS------YKGY 558
              +ALE   R L +  LD  +F     + + T N+++  T     L+ S       K +
Sbjct: 219 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 278

Query: 559 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL 618
             L GE  +  D    L+   ++   SL G  +    + +   +  +W  L+ ++L+   
Sbjct: 279 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 338

Query: 619 RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 678
            ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   ++ Q    +  ++ + 
Sbjct: 339 HLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELK 396

Query: 679 HRKAIILSINLCSPEFTQADSKE---------------------SRDLQDRLSQMNGRWD 717
            ++ +I+S       F      E                     +R L+ +  ++N  W+
Sbjct: 397 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 456

Query: 718 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 777
           ++     +W+  + + L + Q   E +  L L L   +  K    P+  +L  + LQDH 
Sbjct: 457 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHL 515

Query: 778 KQLMQIKHELLESQLRVASLQDMSCQL 804
           +++  ++ E+   +  V+ + D++ QL
Sbjct: 516 EKVKALRGEIAPLKENVSHVNDLARQL 542



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 57/301 (18%), Positives = 121/301 (40%), Gaps = 39/301 (12%)

Query: 24  VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 83
           +N  W+ +   ++ R   L+ET   +QQ   ++     WL   E+E    ++ D+   E 
Sbjct: 206 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETTANVLQDATRKER 263

Query: 84  -------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
                  ++  + + Q+LQ +IE H+    ++    + +L   +  + DA    +Q+   
Sbjct: 264 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SDDAVL--LQRRLD 320

Query: 137 NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTV 196
           N++ +W  +   S+  R  +E +   W++          WL+  +   +  +  G  +  
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380

Query: 197 AKEELKKFEAFQRQV-------------------HECLTQLELINKQYRRLARENRTDSA 237
            +++     AF+R++                    + L  LE + ++ R L  E R  + 
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 440

Query: 238 CS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
              L++   E N  W+ L        R++   + + +E + A D       E+DL+L   
Sbjct: 441 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD-------ELDLKLRQA 493

Query: 297 E 297
           E
Sbjct: 494 E 494


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,584,780
Number of Sequences: 37866
Number of extensions: 1744133
Number of successful extensions: 11540
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 338
Number of HSP's that attempted gapping in prelim test: 8819
Number of HSP's gapped (non-prelim): 1892
length of query: 982
length of database: 18,247,518
effective HSP length: 112
effective length of query: 870
effective length of database: 14,006,526
effective search space: 12185677620
effective search space used: 12185677620
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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