Search of human proteins with 154277116

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154277116 spectrin repeat containing, nuclear envelope 1
isoform 1 [Homo sapiens]
         (8797 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...  1.717e+04   0.0  
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...  1.684e+04   0.0  
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...  6481   0.0  
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...  2051   0.0  
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof...  2049   0.0  
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof...  1890   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                        372   e-102
gi|221316622 dystonin isoform 3 [Homo sapiens]                        372   e-102
gi|221316618 dystonin isoform 2 [Homo sapiens]                        372   e-102
gi|34577047 dystonin isoform 1 [Homo sapiens]                         372   e-102
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             372   e-102
gi|33188445 microfilament and actin filament cross-linker protei...   354   2e-96
gi|33188443 microfilament and actin filament cross-linker protei...   340   5e-92
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo...   337   4e-91
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                   317   4e-85
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                  315   1e-84
gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                   313   6e-84
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo...   309   9e-83
gi|110611228 utrophin [Homo sapiens]                                  296   5e-79
gi|145580592 nesprin-3 [Homo sapiens]                                 285   1e-75
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        273   5e-72
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        270   4e-71
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        270   5e-71
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        269   8e-71
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        268   1e-70
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       268   2e-70
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       267   3e-70
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        267   3e-70
gi|19923599 calmin [Homo sapiens]                                     265   1e-69
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   244   3e-63

>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 1.717e+04 bits (44571), Expect = 0.0
 Identities = 8797/8797 (100%), Positives = 8797/8797 (100%)

Query: 1    MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
            MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
Sbjct: 1    MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60

Query: 61   VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS 120
            VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS
Sbjct: 61   VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPS 120

Query: 121  IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA 180
            IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA
Sbjct: 121  IVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNA 180

Query: 181  KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE 240
            KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE
Sbjct: 181  KKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLE 240

Query: 241  DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP 300
            DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP
Sbjct: 241  DAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILP 300

Query: 301  GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM 360
            GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM
Sbjct: 301  GFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEM 360

Query: 361  KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR 420
            KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR
Sbjct: 361  KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR 420

Query: 421  AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD 480
            AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD
Sbjct: 421  AEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPD 480

Query: 481  QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL 540
            QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL
Sbjct: 481  QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLL 540

Query: 541  QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600
            QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE
Sbjct: 541  QNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600

Query: 601  VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
            VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM
Sbjct: 601  VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660

Query: 661  NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL 720
            NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL
Sbjct: 661  NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL 720

Query: 721  SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE 780
            SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE
Sbjct: 721  SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE 780

Query: 781  EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV 840
            EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV
Sbjct: 781  EGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITV 840

Query: 841  LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ 900
            LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ
Sbjct: 841  LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQ 900

Query: 901  IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL 960
            IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL
Sbjct: 901  IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELL 960

Query: 961  RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL 1020
            RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL
Sbjct: 961  RRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLL 1020

Query: 1021 HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL 1080
            HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL
Sbjct: 1021 HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQL 1080

Query: 1081 IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI 1140
            IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI
Sbjct: 1081 IEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWI 1140

Query: 1141 STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA 1200
            STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA
Sbjct: 1141 STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA 1200

Query: 1201 QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE 1260
            QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE
Sbjct: 1201 QKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAE 1260

Query: 1261 KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST 1320
            KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST
Sbjct: 1261 KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLEST 1320

Query: 1321 LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE 1380
            LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE
Sbjct: 1321 LDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE 1380

Query: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT 1440
            QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT
Sbjct: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKT 1440

Query: 1441 MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI 1500
            MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI
Sbjct: 1441 MEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI 1500

Query: 1501 VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN 1560
            VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN
Sbjct: 1501 VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEEN 1560

Query: 1561 LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV 1620
            LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV
Sbjct: 1561 LRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVV 1620

Query: 1621 NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS 1680
            NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS
Sbjct: 1621 NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASS 1680

Query: 1681 PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE 1740
            PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE
Sbjct: 1681 PEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLE 1740

Query: 1741 QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ 1800
            QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ
Sbjct: 1741 QLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ 1800

Query: 1801 VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV 1860
            VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV
Sbjct: 1801 VALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV 1860

Query: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
            ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE
Sbjct: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920

Query: 1921 SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK 1980
            SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK
Sbjct: 1921 SAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLK 1980

Query: 1981 KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2040
            KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD
Sbjct: 1981 KAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2040

Query: 2041 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2100
            KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK
Sbjct: 2041 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2100

Query: 2101 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
            VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH
Sbjct: 2101 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160

Query: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
            SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM
Sbjct: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220

Query: 2221 AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD 2280
            AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD
Sbjct: 2221 AENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD 2280

Query: 2281 LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK 2340
            LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK
Sbjct: 2281 LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALK 2340

Query: 2341 KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2400
            KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ
Sbjct: 2341 KVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2400

Query: 2401 ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
            ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ
Sbjct: 2401 ASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460

Query: 2461 SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF 2520
            SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF
Sbjct: 2461 SKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSF 2520

Query: 2521 EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR 2580
            EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR
Sbjct: 2521 EDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQR 2580

Query: 2581 GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640
            GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV
Sbjct: 2581 GQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640

Query: 2641 KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2700
            KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ
Sbjct: 2641 KAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2700

Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
            RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL
Sbjct: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760

Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
            QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ
Sbjct: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL
Sbjct: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
            SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT
Sbjct: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3000
            QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH
Sbjct: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3000

Query: 3001 KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060
            KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN
Sbjct: 3001 KGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060

Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
            KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK
Sbjct: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120

Query: 3121 LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV 3180
            LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV
Sbjct: 3121 LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV 3180

Query: 3181 SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL 3240
            SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL
Sbjct: 3181 SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL 3240

Query: 3241 WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3300
            WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI
Sbjct: 3241 WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3300

Query: 3301 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3360
            HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ
Sbjct: 3301 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3360

Query: 3361 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3420
            QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA
Sbjct: 3361 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3420

Query: 3421 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3480
            ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA
Sbjct: 3421 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3480

Query: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3540
            KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV
Sbjct: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3540

Query: 3541 HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
            HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL
Sbjct: 3541 HCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600

Query: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
            RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA
Sbjct: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660

Query: 3661 RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720
            RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW
Sbjct: 3661 RAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720

Query: 3721 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3780
            YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE
Sbjct: 3721 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3780

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH
Sbjct: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
            VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ
Sbjct: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900

Query: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
            SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT
Sbjct: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960

Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020
            QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI
Sbjct: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020

Query: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080
            CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR
Sbjct: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080

Query: 4081 ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS 4140
            ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS
Sbjct: 4081 ALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKS 4140

Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT 4200
            ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT
Sbjct: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLT 4200

Query: 4201 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4260
            KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW
Sbjct: 4201 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4260

Query: 4261 DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH 4320
            DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH
Sbjct: 4261 DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSH 4320

Query: 4321 LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA 4380
            LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA
Sbjct: 4321 LEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA 4380

Query: 4381 QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL 4440
            QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL
Sbjct: 4381 QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL 4440

Query: 4441 VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ 4500
            VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ
Sbjct: 4441 VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQ 4500

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560
            ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN
Sbjct: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560

Query: 4561 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4620
            LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL
Sbjct: 4561 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4620

Query: 4621 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4680
            TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI
Sbjct: 4621 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4680

Query: 4681 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
            ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF
Sbjct: 4681 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740

Query: 4741 RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE 4800
            RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE
Sbjct: 4741 RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE 4800

Query: 4801 QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS 4860
            QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS
Sbjct: 4801 QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS 4860

Query: 4861 WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4920
            WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI
Sbjct: 4861 WQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4920

Query: 4921 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4980
            QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA
Sbjct: 4921 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4980

Query: 4981 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS 5040
            LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS
Sbjct: 4981 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFS 5040

Query: 5041 TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT 5100
            TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT
Sbjct: 5041 TEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCT 5100

Query: 5101 AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV 5160
            AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV
Sbjct: 5101 AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV 5160

Query: 5161 ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV 5220
            ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV
Sbjct: 5161 ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV 5220

Query: 5221 KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ 5280
            KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ
Sbjct: 5221 KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ 5280

Query: 5281 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ 5340
            DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ
Sbjct: 5281 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ 5340

Query: 5341 ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL 5400
            ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL
Sbjct: 5341 ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL 5400

Query: 5401 AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT 5460
            AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT
Sbjct: 5401 AEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKT 5460

Query: 5461 DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS 5520
            DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS
Sbjct: 5461 DQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS 5520

Query: 5521 KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID 5580
            KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID
Sbjct: 5521 KLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID 5580

Query: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640
            SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE
Sbjct: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640

Query: 5641 LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE 5700
            LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE
Sbjct: 5641 LKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPE 5700

Query: 5701 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 5760
            DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE
Sbjct: 5701 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 5760

Query: 5761 IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
            IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE
Sbjct: 5761 IEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820

Query: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5880
            VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR
Sbjct: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5880

Query: 5881 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 5940
            SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL
Sbjct: 5881 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDL 5940

Query: 5941 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM 6000
            QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM
Sbjct: 5941 QRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQM 6000

Query: 6001 AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK 6060
            AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK
Sbjct: 6001 AEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMK 6060

Query: 6061 ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME 6120
            ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME
Sbjct: 6061 ASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDME 6120

Query: 6121 AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180
            AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ
Sbjct: 6121 AQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180

Query: 6181 RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6240
            RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE
Sbjct: 6181 RALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6240

Query: 6241 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6300
            LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE
Sbjct: 6241 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6300

Query: 6301 SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ 6360
            SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ
Sbjct: 6301 SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQ 6360

Query: 6361 AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE 6420
            AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE
Sbjct: 6361 AFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE 6420

Query: 6421 ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK 6480
            ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK
Sbjct: 6421 ILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMK 6480

Query: 6481 ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI 6540
            ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI
Sbjct: 6481 ERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGI 6540

Query: 6541 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
            IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD
Sbjct: 6541 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
            LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET
Sbjct: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660

Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
            QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE
Sbjct: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720

Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
            NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT
Sbjct: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780

Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
            NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN
Sbjct: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840

Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6900
            AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE
Sbjct: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6900

Query: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
            KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI
Sbjct: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960

Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
            NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL
Sbjct: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020

Query: 7021 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 7080
            LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK
Sbjct: 7021 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 7080

Query: 7081 IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD 7140
            IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD
Sbjct: 7081 IEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFD 7140

Query: 7141 KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE 7200
            KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE
Sbjct: 7141 KINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE 7200

Query: 7201 CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
            CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED
Sbjct: 7201 CHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
            RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS
Sbjct: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP
Sbjct: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI 7440
            SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI
Sbjct: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI 7440

Query: 7441 SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500
            SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF
Sbjct: 7441 SSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500

Query: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
            QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS
Sbjct: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560

Query: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS 7620
            QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS
Sbjct: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGS 7620

Query: 7621 YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK 7680
            YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK
Sbjct: 7621 YILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEK 7680

Query: 7681 GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740
            GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA
Sbjct: 7681 GIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740

Query: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800
            YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME
Sbjct: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800

Query: 7801 SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
            SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG
Sbjct: 7801 SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860

Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
            KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE
Sbjct: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920

Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
            EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW
Sbjct: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980

Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 8040
            RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK
Sbjct: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 8040

Query: 8041 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 8100
            KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL
Sbjct: 8041 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 8100

Query: 8101 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 8160
            RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH
Sbjct: 8101 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 8160

Query: 8161 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 8220
            NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH
Sbjct: 8161 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 8220

Query: 8221 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
            DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS
Sbjct: 8221 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280

Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 8340
            IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK
Sbjct: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 8340

Query: 8341 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 8400
            ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES
Sbjct: 8341 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 8400

Query: 8401 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8460
            LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE
Sbjct: 8401 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8460

Query: 8461 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 8520
            EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL
Sbjct: 8461 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 8520

Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
            QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID
Sbjct: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580

Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
            SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN
Sbjct: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640

Query: 8641 RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR 8700
            RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR
Sbjct: 8641 RLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPR 8700

Query: 8701 GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG 8760
            GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG
Sbjct: 8701 GKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIG 8760

Query: 8761 LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8797
            LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Sbjct: 8761 LACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8797


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 1.684e+04 bits (43712), Expect = 0.0
 Identities = 8669/8828 (98%), Positives = 8685/8828 (98%), Gaps = 110/8828 (1%)

Query: 1    MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
            MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
Sbjct: 1    MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60

Query: 61   VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK-------IKLVNINSTD 113
            VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK       IKLVNINSTD
Sbjct: 61   VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD 120

Query: 114  IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 173
            IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
Sbjct: 121  IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 180

Query: 174  TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 233
            TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR
Sbjct: 181  TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 240

Query: 234  SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 293
            SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ
Sbjct: 241  SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 300

Query: 294  EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 353
            EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
Sbjct: 301  EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 360

Query: 354  FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 413
            FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT
Sbjct: 361  FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 420

Query: 414  IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 473
            IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN
Sbjct: 421  IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 480

Query: 474  GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 533
            GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
Sbjct: 481  GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 540

Query: 534  ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 593
            ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ
Sbjct: 541  ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 600

Query: 594  WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 653
            WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW
Sbjct: 601  WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 660

Query: 654  IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 713
            IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
Sbjct: 661  IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 720

Query: 714  TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 773
            TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI
Sbjct: 721  TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 780

Query: 774  TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 833
            TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK
Sbjct: 781  TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 840

Query: 834  INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 893
            INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
Sbjct: 841  INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 900

Query: 894  QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 953
            QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK
Sbjct: 901  QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 960

Query: 954  GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1013
            GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG
Sbjct: 961  GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1020

Query: 1014 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1073
            EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
Sbjct: 1021 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1080

Query: 1074 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1133
            CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF
Sbjct: 1081 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1140

Query: 1134 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
            SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE
Sbjct: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200

Query: 1194 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1253
            VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
Sbjct: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1260

Query: 1254 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1313
            EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE
Sbjct: 1261 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1320

Query: 1314 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1373
            LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE
Sbjct: 1321 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1380

Query: 1374 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1433
            SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
Sbjct: 1381 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1440

Query: 1434 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1493
            LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI
Sbjct: 1441 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1500

Query: 1494 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1553
            ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ
Sbjct: 1501 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1560

Query: 1554 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1613
            QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
Sbjct: 1561 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1620

Query: 1614 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1673
            ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER
Sbjct: 1621 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1680

Query: 1674 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1733
            GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK
Sbjct: 1681 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1740

Query: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
            MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
Sbjct: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800

Query: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1853
            ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF
Sbjct: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1860

Query: 1854 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1913
            EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL
Sbjct: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920

Query: 1914 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1973
            QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
Sbjct: 1921 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1980

Query: 1974 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2033
            DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH
Sbjct: 1981 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2040

Query: 2034 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2093
            ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN
Sbjct: 2041 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2100

Query: 2094 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
            LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
Sbjct: 2101 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160

Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
            SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS
Sbjct: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220

Query: 2214 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2273
            NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD
Sbjct: 2221 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2280

Query: 2274 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2333
            LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
Sbjct: 2281 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2340

Query: 2334 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393
            ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS
Sbjct: 2341 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400

Query: 2394 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
            QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL
Sbjct: 2401 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2460

Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2513
            DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
Sbjct: 2461 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2520

Query: 2514 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2573
            ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES
Sbjct: 2521 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2580

Query: 2574 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2633
            LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL
Sbjct: 2581 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2640

Query: 2634 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2693
            QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
Sbjct: 2641 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2700

Query: 2694 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2753
            SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD
Sbjct: 2701 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2760

Query: 2754 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2813
            QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA
Sbjct: 2761 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2820

Query: 2814 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2873
            QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
Sbjct: 2821 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2880

Query: 2874 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2933
            SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW
Sbjct: 2881 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2940

Query: 2934 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 2993
            EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE
Sbjct: 2941 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 3000

Query: 2994 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3053
            EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
Sbjct: 3001 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3060

Query: 3054 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3113
            ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE
Sbjct: 3061 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3120

Query: 3114 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3173
            SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI
Sbjct: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180

Query: 3174 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3233
            QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
Sbjct: 3181 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3240

Query: 3234 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3293
            KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ
Sbjct: 3241 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3300

Query: 3294 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3353
            DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP
Sbjct: 3301 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3360

Query: 3354 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3413
            EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
Sbjct: 3361 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3420

Query: 3414 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3473
            ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY
Sbjct: 3421 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3480

Query: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3533
            RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR
Sbjct: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540

Query: 3534 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
            DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
Sbjct: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600

Query: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
            NNVVNKLRLMEQKFQQVDEWLKTAEEK                      KWHEEVTAYRD
Sbjct: 3601 NNVVNKLRLMEQKFQQVDEWLKTAEEK----------------------KWHEEVTAYRD 3638

Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
            EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS
Sbjct: 3639 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3698

Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
            LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER
Sbjct: 3699 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3758

Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
            AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA
Sbjct: 3759 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3818

Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK 3893
            EYQEILHVPE                          EP ++   +K +            
Sbjct: 3819 EYQEILHVPE--------------------------EPKMELYEKKAQL----------- 3841

Query: 3894 DKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLET 3953
                   S Y+           SL+  V  HE     ++E  + LL++   +   D ++ 
Sbjct: 3842 -------SKYK-----------SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID- 3882

Query: 3954 SSLETITQQLAH-HKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 4012
              L++  Q L    KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG
Sbjct: 3883 -QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 3941

Query: 4013 TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA 4072
            TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA
Sbjct: 3942 TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA 4001

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW
Sbjct: 4002 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4061

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTI 4192
            EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTI
Sbjct: 4062 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTI 4121

Query: 4193 IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVF 4252
            IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVF
Sbjct: 4122 IEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVF 4181

Query: 4253 LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE 4312
            LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE
Sbjct: 4182 LEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE 4241

Query: 4313 LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4372
            LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK
Sbjct: 4242 LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4301

Query: 4373 QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQS 4432
            QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQS
Sbjct: 4302 QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQS 4361

Query: 4433 HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ 4492
            HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ
Sbjct: 4362 HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQ 4421

Query: 4493 VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSH 4552
            VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSH
Sbjct: 4422 VKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSH 4481

Query: 4553 RLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQS 4612
            RLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQS
Sbjct: 4482 RLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQS 4541

Query: 4613 PEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA 4672
            PEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA
Sbjct: 4542 PEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA 4601

Query: 4673 RKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDE 4732
            RKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDE
Sbjct: 4602 RKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDE 4661

Query: 4733 LNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER 4792
            LNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER
Sbjct: 4662 LNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER 4721

Query: 4793 QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4852
            QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE
Sbjct: 4722 QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4781

Query: 4853 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4912
            KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY
Sbjct: 4782 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4841

Query: 4913 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSE 4972
            LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSE
Sbjct: 4842 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSE 4901

Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL 5032
            LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL
Sbjct: 4902 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL 4961

Query: 5033 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ 5092
            KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ
Sbjct: 4962 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ 5021

Query: 5093 VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV 5152
            VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV
Sbjct: 5022 VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV 5081

Query: 5153 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE 5212
            NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE
Sbjct: 5082 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE 5141

Query: 5213 WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR 5272
            WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR
Sbjct: 5142 WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR 5201

Query: 5273 QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQI 5332
            QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQI
Sbjct: 5202 QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQI 5261

Query: 5333 NSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL 5392
            NSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL
Sbjct: 5262 NSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTIL 5321

Query: 5393 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5452
            PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT
Sbjct: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381

Query: 5453 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5512
            DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI
Sbjct: 5382 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5441

Query: 5513 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5572
            RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL
Sbjct: 5442 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5501

Query: 5573 LEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK 5632
            LEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK
Sbjct: 5502 LEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK 5561

Query: 5633 DMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
            DMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC
Sbjct: 5562 DMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5621

Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQ 5752
            QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQ
Sbjct: 5622 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQ 5681

Query: 5753 LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5812
            LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA
Sbjct: 5682 LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741

Query: 5813 TMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE 5872
            TMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE
Sbjct: 5742 TMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSE 5801

Query: 5873 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5932
            ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS
Sbjct: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861

Query: 5933 ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5992
            ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP
Sbjct: 5862 ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5921

Query: 5993 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 6052
            GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE
Sbjct: 5922 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAE 5981

Query: 6053 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6112
            RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP
Sbjct: 5982 RMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSP 6041

Query: 6113 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL 6172
            PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL
Sbjct: 6042 PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL 6101

Query: 6173 KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ 6232
            KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ
Sbjct: 6102 KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ 6161

Query: 6233 QQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE 6292
            QQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE
Sbjct: 6162 QQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE 6221

Query: 6293 DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 6352
            DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT
Sbjct: 6222 DQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVT 6281

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
            SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET
Sbjct: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
            ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV
Sbjct: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401

Query: 6473 NQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG 6532
            NQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG
Sbjct: 6402 NQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG 6461

Query: 6533 LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE 6592
            LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE
Sbjct: 6462 LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE 6521

Query: 6593 RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKII 6652
            RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKII
Sbjct: 6522 RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKII 6581

Query: 6653 SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6712
            SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI
Sbjct: 6582 SFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641

Query: 6713 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQL 6772
            PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQL
Sbjct: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQL 6701

Query: 6773 GECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
            GECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQEL
Sbjct: 6702 GECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6761

Query: 6833 EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL 6892
            EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL
Sbjct: 6762 EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLL 6821

Query: 6893 TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQK 6952
            TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQK
Sbjct: 6822 TNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQK 6881

Query: 6953 YKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTE 7012
            YKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTE
Sbjct: 6882 YKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTE 6941

Query: 7013 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
            KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK
Sbjct: 6942 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001

Query: 7073 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
            AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW
Sbjct: 7002 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7061

Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
            SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS
Sbjct: 7062 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7121

Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
            ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA
Sbjct: 7122 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7181

Query: 7253 STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 7312
            STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ
Sbjct: 7182 STVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 7241

Query: 7313 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7372
            QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE
Sbjct: 7242 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7301

Query: 7373 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN 7432
            EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN
Sbjct: 7302 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN 7361

Query: 7433 LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7492
            LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE
Sbjct: 7362 LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7421

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
            QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ
Sbjct: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7481

Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
            QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK
Sbjct: 7482 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541

Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
            VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL
Sbjct: 7542 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7601

Query: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS 7732
            KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS
Sbjct: 7602 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLS 7661

Query: 7733 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 7792
            LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL
Sbjct: 7662 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 7721

Query: 7793 CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7852
            CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA
Sbjct: 7722 CEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7781

Query: 7853 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 7912
            SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI
Sbjct: 7782 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 7841

Query: 7913 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 7972
            VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA
Sbjct: 7842 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 7901

Query: 7973 TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 8032
            TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY
Sbjct: 7902 TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIY 7961

Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
            TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL
Sbjct: 7962 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8021

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAF 8152
            QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAF
Sbjct: 8022 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAF 8081

Query: 8153 QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR 8212
            QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR
Sbjct: 8082 QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIR 8141

Query: 8213 LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR 8272
            LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR
Sbjct: 8142 LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGR 8201

Query: 8273 DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL-------- 8324
            DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL        
Sbjct: 8202 DTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPES 8261

Query: 8325 ---------------SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 8369
                           SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS
Sbjct: 8262 PEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTS 8321

Query: 8370 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQAL 8429
            YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQAL
Sbjct: 8322 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQAL 8381

Query: 8430 SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ 8489
            SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ
Sbjct: 8382 SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQ 8441

Query: 8490 KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8549
            KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL
Sbjct: 8442 KAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8501

Query: 8550 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8609
            MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV
Sbjct: 8502 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561

Query: 8610 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
            ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL
Sbjct: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621

Query: 8670 SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLS 8729
            SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLS
Sbjct: 8622 SSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLS 8681

Query: 8730 EPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLR 8789
            EPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLR
Sbjct: 8682 EPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLR 8741

Query: 8790 YTNGPPPL 8797
            YTNGPPPL
Sbjct: 8742 YTNGPPPL 8749


>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
            [Homo sapiens]
          Length = 3321

 Score = 6481 bits (16814), Expect = 0.0
 Identities = 3321/3321 (100%), Positives = 3321/3321 (100%)

Query: 5477 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 5536
            MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML
Sbjct: 1    MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60

Query: 5537 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 5596
            ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV
Sbjct: 61   ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
            YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT
Sbjct: 121  YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180

Query: 5657 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 5716
            SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ
Sbjct: 181  SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240

Query: 5717 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 5776
            EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA
Sbjct: 241  EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300

Query: 5777 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 5836
            QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL
Sbjct: 301  QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360

Query: 5837 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 5896
            PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI
Sbjct: 361  PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420

Query: 5897 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5956
            AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR
Sbjct: 421  AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480

Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 6016
            TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE
Sbjct: 481  TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540

Query: 6017 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 6076
            INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL
Sbjct: 541  INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600

Query: 6077 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 6136
            EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK
Sbjct: 601  EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660

Query: 6137 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 6196
            VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE
Sbjct: 661  VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720

Query: 6197 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 6256
            KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE
Sbjct: 721  KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780

Query: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
            EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV
Sbjct: 781  EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840

Query: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6376
            LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS
Sbjct: 841  LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900

Query: 6377 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6436
            IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN
Sbjct: 901  IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960

Query: 6437 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 6496
            KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL
Sbjct: 961  KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020

Query: 6497 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 6556
            FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS
Sbjct: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080

Query: 6557 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6616
            MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140

Query: 6617 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 6676
            VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200

Query: 6677 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6736
            AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK
Sbjct: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260

Query: 6737 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
            SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH
Sbjct: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320

Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
            WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK
Sbjct: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380

Query: 6857 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6916
            SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI
Sbjct: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440

Query: 6917 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6976
            SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ
Sbjct: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500

Query: 6977 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 7036
            ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT
Sbjct: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560

Query: 7037 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 7096
            WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV
Sbjct: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620

Query: 7097 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 7156
            SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF
Sbjct: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680

Query: 7157 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 7216
            RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV
Sbjct: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740

Query: 7217 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 7276
            NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD
Sbjct: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800

Query: 7277 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 7336
            DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL
Sbjct: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860

Query: 7337 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 7396
            EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL
Sbjct: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920

Query: 7397 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 7456
            KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL
Sbjct: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980

Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
            QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII
Sbjct: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040

Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
            DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR
Sbjct: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100

Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
            KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD
Sbjct: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160

Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 7696
            SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL
Sbjct: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220

Query: 7697 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7756
            SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL
Sbjct: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280

Query: 7757 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 7816
            LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE
Sbjct: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340

Query: 7817 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7876
            KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR
Sbjct: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400

Query: 7877 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7936
            VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI
Sbjct: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE
Sbjct: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520

Query: 7997 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
            TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL
Sbjct: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580

Query: 8057 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 8116
            ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA
Sbjct: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640

Query: 8117 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
            RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK
Sbjct: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700

Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8236
            SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS
Sbjct: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760

Query: 8237 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 8296
            DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE
Sbjct: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820

Query: 8297 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 8356
            SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII
Sbjct: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENII 2880

Query: 8357 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 8416
            RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG
Sbjct: 2881 RSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 2940

Query: 8417 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 8476
            VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ
Sbjct: 2941 VIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQ 3000

Query: 8477 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
            TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS
Sbjct: 3001 TIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS 3060

Query: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
            LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM
Sbjct: 3061 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 3120

Query: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8656
            QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL
Sbjct: 3121 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 3180

Query: 8657 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 8716
            EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH
Sbjct: 3181 EKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPH 3240

Query: 8717 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 8776
            SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL
Sbjct: 3241 SRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCAL 3300

Query: 8777 SNNFARSFHPMLRYTNGPPPL 8797
            SNNFARSFHPMLRYTNGPPPL
Sbjct: 3301 SNNFARSFHPMLRYTNGPPPL 3321



 Score =  221 bits (562), Expect = 3e-56
 Identities = 613/3378 (18%), Positives = 1294/3378 (38%), Gaps = 366/3378 (10%)

Query: 1170 IRNGVTKRGETLSWLKSRLKVLTEV------SSENEAQKQGDELAKLSSSFKALVTLLSE 1223
            ++  + + G+    L  ++  LTE+       +EN   K     + L    + L  +L  
Sbjct: 7    VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 66

Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEEL----------ISGSKEVQEQAEKILDTENLFEAQQ 1273
            +EK        + +  I  NS  +L          +  SKE+  + E + +      +  
Sbjct: 67   IEK-----AKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121

Query: 1274 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQER 1333
                  Q+   +  +  +++Q I    Q    L D   ++++K E+ L  L+ + E+   
Sbjct: 122  CTEKMSQQVAELGRETEELRQMIKIRLQN---LQDAA-KDMKKFEAELKKLQAALEQA-- 175

Query: 1334 RIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA 1393
              Q TL   E        V R   +   SH + L  S +ESL  +               
Sbjct: 176  --QATLTSPE--------VGRLSLKEQLSHRQHL-LSEMESLKPK--------------- 209

Query: 1394 VQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGS 1453
            VQA  L + A  IP        L   A  ++E+  +L+ T  +    M+    +++ +  
Sbjct: 210  VQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 269

Query: 1454 NFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSF--- 1510
              + L   I    +E+     ++S     I +++  I   E     I G +E+  S    
Sbjct: 270  EMKHLQQLIEGAHREIEDKPVATS----NIQELQAQISRHEELAQKIKGYQEQIASLNSK 325

Query: 1511 -AQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTIL----GHLSQQQKFEENLRKIQ 1565
                    + A +   +T++    E L E  + L+G +L     H S           + 
Sbjct: 326  CKMLTMKAKHATMLLTVTEV----EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLL 381

Query: 1566 QSVSEFEDKLAVPIKICSS--------ATETYKVLQEHMDLCQALES----LSSAITAFS 1613
              V+E   +     +I S            T   + + +   QAL +      +A    S
Sbjct: 382  SPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPS 441

Query: 1614 ASARKVVNRDSCVQEAAA----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1669
             SA +          A A    LQ+ +E +     E+Q  L   L   Q+ +  L S  T
Sbjct: 442  TSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST 501

Query: 1670 WLERGEAKAS-------SPEMDISADRVKVEGEL-------QLIQALQNEVVS------- 1708
             +E  E K S       SPE  ++  +  ++  L       +L  +L  E+VS       
Sbjct: 502  KMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADP 561

Query: 1709 --QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1766
              Q +  S L  L E + ++  K   K   L  E+L+++  +      ++   LQ    E
Sbjct: 562  AEQLALQSTLTVLAERMSTIRMKASGKRQLLE-EKLNDQLEE-----QRQEQALQRYRCE 615

Query: 1767 HQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGH 1826
              + D  LLS    +   LS  +       MD +  L   ++   E+E K   L  L  H
Sbjct: 616  ADELDSWLLSTKATLDTALSPPKEP-----MDMEAQLMDCQNMLVEIEQKVVALSELSVH 670

Query: 1827 LAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ 1886
               L          LL+GKA       +EA Q+  + +     L E       L   L  
Sbjct: 671  NENL----------LLEGKAHTK----DEAEQLAGKLRRLKGSLLE-------LQRALHD 709

Query: 1887 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1946
             +  ++ T +  K ESD+   DL  A Q+    E  A +            +   ++QR 
Sbjct: 710  KQLNMQGT-AQEKEESDV---DLT-ATQSPGVQEWLAQA------------RTTWTQQRQ 752

Query: 1947 SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD-----QKEELLKSIEDIE-ER 2000
            S      +L  E+   ++LL +  S  + + +   A +      +K ++L     +E E+
Sbjct: 753  SSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 812

Query: 2001 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREI 2060
            +  E       ++L Q      +L   +   E E        + ++   +       ++ 
Sbjct: 813  SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 872

Query: 2061 NRLEVTWDDTKRLIHENQGQCCGL----IDLMREYQNLKSAVSKVLENASSVIVTRTTIK 2116
            + +    D   +   E   Q  G     I L ++  +  SA S  L++    +   T + 
Sbjct: 873  SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL 932

Query: 2117 DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD 2176
             +E     F++   AK+      K++     K K+L S+    +  +  +++  +   + 
Sbjct: 933  PEETETCLFNQEILAKDI-----KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLG 987

Query: 2177 KW--LD--VSEKLEENMDRLRVSLSIWDDV----LSTRDE----IEGWSNNCVPQMAENI 2224
            +   LD  V+++  +  +RL+  L+  +D+     S  D     ++  +N     +AE I
Sbjct: 988  RLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI 1047

Query: 2225 SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQK 2284
              +    +AE+ LKEF++ +     R ++L  +   ++EL+K  +   +L  I       
Sbjct: 1048 EAIQ---QAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSG 1104

Query: 2285 LEHAKEITEVAKGTLKDFT-AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVK 2343
            L     +    +  L+D      T  EK   D         + ++  ++ E  + L K K
Sbjct: 1105 LNQNLTLKSQYERALQDLADLLETGQEKMAGD---------QKIIVSSKEEIQQLLDKHK 1155

Query: 2344 DIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASL 2403
            +     Q  +S++  T+    +L RK  S  ++   +  T L+ +  AV +   K    L
Sbjct: 1156 EY---FQGLESHMILTE----TLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208

Query: 2404 QESLE--KHFSESMQEFQ------EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDS 2455
            +  LE   H  E  QE        E  + +    +E+ DR  D   L       Q++  S
Sbjct: 1209 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL------YQHLKSS 1262

Query: 2456 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2515
            +++ Q KL  V  +G+ L   +S    S ++ Q+ +  E + +   +  K+   L+    
Sbjct: 1263 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 1319

Query: 2516 ELGSFEDQHRKLNLWIHEMEER--FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2573
                ++ +   L  W+   ++R  F T+      Q +   ++ ++    F  E+  A+ S
Sbjct: 1320 HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV-DAQSS 1378

Query: 2574 LDK--LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLR---MTKEKLRSCQV-ALQEHE 2627
            L    LS   QLL  +           S++ +   +LL      +EKL   Q+  L    
Sbjct: 1379 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 1438

Query: 2628 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK 2687
            A+ E +  +      IQ      ++++G K  + + L + +   +     ++ ++  + +
Sbjct: 1439 AISEVMSWISLMENVIQKDEDNIKNSIGYK-AIHEYLQKYKGFKIDINCKQLTVDF-VNQ 1496

Query: 2688 GEQALRSSNKEGQRVIQT----QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2743
                + S + E +R  +T    QL  + + W  +          LE ++  W++Y     
Sbjct: 1497 SVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQ 1556

Query: 2744 QLEQWMESVDQKI--EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHR----LIAKS 2797
             L+ W E+ ++++  +H +  Q  ++        L+ ++   E     + +    LI   
Sbjct: 1557 CLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK 1616

Query: 2798 RELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLH 2857
            +E        + ++  Q       + ++   K  ++ V +    H +  D ++ +   L 
Sbjct: 1617 KEDVSSIVMSTLRELGQTW--ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY---LM 1671

Query: 2858 SAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE 2917
             A+  L R+  ++G   A Q ++  ++ L D  E     L +  S+  ++ +       E
Sbjct: 1672 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 1731

Query: 2918 LMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ-LEQALEQFSALL 2976
             +   ++ +   W    + + +     + L+ Q+    +++S Q A  ++Q  ++ + LL
Sbjct: 1732 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALL-QLWQRYKDYSKQCASTVQQQEDRTNELL 1790

Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
            K    +         D+E+        ++L  L   +     L  +L E  +   D S  
Sbjct: 1791 KAATNK------DIADDEVATWIQDCNDLLKGLGTVKDSLFFLH-ELGEQLKQQVDASAA 1843

Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQ-----QRFRKAFRDFQQWLVNAKITTAKCF 3091
            S   S  +     LC      C+ +  +       + F K+    + W+V A+       
Sbjct: 1844 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-- 1901

Query: 3092 DIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTL-----LTKEKAKGIQAK 3146
              P + S++ST    IQE + E +    K + M    + L+ L     L  ++ K +Q  
Sbjct: 1902 QDPSHSSDLST----IQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQN- 1956

Query: 3147 VTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYD 3205
                   W    S   ++ S L++  +Q + F    E   ++L +TE K+  E S     
Sbjct: 1957 ---LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQH 2013

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE-GQAASKS-FRHRVSQLSSQYLA 3263
            L  ++R  +  Q+   E+   +  L+ +    Q+L E GQ   +  F  +++ LS+Q+  
Sbjct: 2014 LLEQQRAHELFQA---EMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQG 2070

Query: 3264 LSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHM----LDSYCHPTSDKSVLDSR 3319
            +    +++   +D  + +  ++    ++L+ W+ +  ++    L S   P      L   
Sbjct: 2071 VIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDE 2130

Query: 3320 TLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3379
                E +   +Q   I   + V  G+ +L +        +Q +L  +++ W S       
Sbjct: 2131 VQFKEKVFLRQQGSYI---LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 2187

Query: 3380 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEV 3439
             K +L   L  W   + G+      + + +  L++S   H E      M  + K L   V
Sbjct: 2188 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQM--RCKELENAV 2245

Query: 3440 LSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKE-----AVTKSEKLVRLH 3494
             S++  L  + +    ++  Y++  ++  L ER   +Q + +E     ++ + +   RL+
Sbjct: 2246 GSWTDDLTQLSLLKDTLSA-YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 2304

Query: 3495 Q--EYQRDLKAFEVWLGQEQEKLDQYS------VLEGDAHTHETTLRDLQELQVHCAE-G 3545
            +   +    K    WL Q + K+ Q        ++E     ++  +   QE ++   + G
Sbjct: 2305 EWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMG 2364

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
            + L  +   ++   I   + +  DR        WQ     ++    +    +  ++ +++
Sbjct: 2365 ERLAKASHESKASEIEYKLGKVNDR--------WQHLLDLIAARVKKLKETLVAVQQLDK 2416

Query: 3606 KFQQVDEWLKTAEEKVS-PRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQE 3664
                +  WL   E +++ P      N    + +L++ ++   ++  +   V  V    + 
Sbjct: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476

Query: 3665 ILDESHVNSRMG-CQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3718
            +L +    +    C + Q     L  R++ +    +E+   +EE  +  ++     S + 
Sbjct: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536

Query: 3719 DWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL 3778
            DW  S+ +     ++    V   +  ++LK  E   + + +  + L+   ++  R  +  
Sbjct: 2537 DWLKSSERTAAFPSSS--GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAREN 2594

Query: 3779 EEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEI 3838
                A  L++ +H+  ++   L   V      L+  +   +EF     ++  W+ E    
Sbjct: 2595 RTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMD-- 2652

Query: 3839 LHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT---LKDK 3895
            L +         + +A++ + K+ QQ +  +   ++ +  +GE L+E  + +    ++++
Sbjct: 2653 LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 2712

Query: 3896 IDQLQSDYQDLCS-IGKEHVFSLEAKVKDHE----DYNSELQEVEK-----WLLQMSGRL 3945
            +D+L+   Q++   + + H   +   + D E    D   EL++        W  + +  L
Sbjct: 2713 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772

Query: 3946 VAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 4005
            ++P      SL ++ Q L   ++  +  A  +     L+   D  + +  +   ++   +
Sbjct: 2773 LSPQPSSNLSL-SLAQPLRSERSGRDTPASVDSI--PLEWDHDYDLSRDLESAMSRALPS 2829

Query: 4006 VHAHLQGTKDSYSAICSTAQRMYQSLEHEL-QKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
                 Q  KD Y          + +LE ++ Q   +  D+  Q Q   + ++      P+
Sbjct: 2830 EDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 2889

Query: 4065 PPLSR-------AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE-- 4115
               S         E    +   + L+ + +   + L    +L +   +T A  I + E  
Sbjct: 2890 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELL 2948

Query: 4116 --QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVS 4173
              Q + ++L   QNL Q W++     + +W +L D +++L+ ++R     ++   +  + 
Sbjct: 2949 QAQALSKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007

Query: 4174 QVKDFVKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCL 4230
            ++K+  K +  ++A   S+N    +  +   KE       ++ +N +W  +C        
Sbjct: 3008 KLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRG 3067

Query: 4231 QREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQ 4286
              ++ L + + +H+  + + + LE      + +    +  DAE    H + L ++   L 
Sbjct: 3068 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 3127

Query: 4287 ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4346
            E +  +  L+D   +++ +    D    KE+   +  R      L+ +++   +  LE+L
Sbjct: 3128 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKL 3183

Query: 4347 NVVQSRFQELMEWAEEQQ 4364
              V S  Q+L  W+   +
Sbjct: 3184 LDVSSSQQDLSSWSSADE 3201



 Score =  197 bits (500), Expect = 5e-49
 Identities = 625/3331 (18%), Positives = 1275/3331 (38%), Gaps = 467/3331 (14%)

Query: 2006 LKEPTRQALQQRLRVFNQLEDELNSH----EHELCWLKDKAKQIAQKDVAF--------- 2052
            L + T +  + RL   NQ    L  +    E  L W+ +KAK +A   +A+         
Sbjct: 31   LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTIAWNSASQLREQ 89

Query: 2053 ----------APEVDREINRLEVTWDDTKRLIHENQGQCCG-----LIDLMREYQNLKSA 2097
                      + E+D E+  +      T++L +     C       + +L RE + L+  
Sbjct: 90   YILHQTLLEESKEIDSELEAM------TEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 143

Query: 2098 VSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL 2156
            +   L+N           + + + L+ A  + +         +  L    S  +HLLSE+
Sbjct: 144  IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 203

Query: 2157 KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNC 2216
            + +        K          L + E +         SL +    L  ++E     +  
Sbjct: 204  ESLKP------KVQAVQLCQSALRIPEDVV-------ASLPLCHAALRLQEEASRLQHTA 250

Query: 2217 VPQMAENISNLDNHLRAEEL-LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQ 2275
            + Q         N ++A  +  +++E E+K+    +E  H ++ D    T N++      
Sbjct: 251  IQQC--------NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ------ 296

Query: 2276 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNET 2335
                +L  ++   +E+ +  KG  +   + +++ +           K + + M     E 
Sbjct: 297  ----ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT-------MKAKHATMLLTVTEV 345

Query: 2336 CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQL 2395
                +  +D+  EL    S   S        C    S   E  G   T          + 
Sbjct: 346  EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRS 405

Query: 2396 CS---KTQASLQESLEKHFSESMQEFQ--EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQ 2450
             S    T AS+ + +  + + S +  Q     +    +A +     G      AKL DLQ
Sbjct: 406  PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ 465

Query: 2451 NILDSVSDGQSKLDAVTQEGQTLYAHLSKQ--IVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
               +++       + ++++ +TLY  L +Q     S+Q   TK  E  +  L +  +  +
Sbjct: 466  RSWETLK------NVISEKQRTLYEALERQQKYQDSLQSISTKM-EAIELKLSESPEPGR 518

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
            + +   +E  +  D+   L   I+E++     E + ES +  P ++  +      L E +
Sbjct: 519  SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 578

Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQ-------NLLRMTKEKLRSCQV 2621
            +      K S + QLL E+ +   +E R   Q L  ++       + L  TK  L +   
Sbjct: 579  STIRM--KASGKRQLLEEKLNDQLEEQRQ-EQALQRYRCEADELDSWLLSTKATLDTALS 635

Query: 2622 ALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKL 2681
              +E   +E  L      +  I+ ++                LS   + LL++G+   K 
Sbjct: 636  PPKEPMDMEAQLMDCQNMLVEIEQKVVAL-----------SELSVHNENLLLEGKAHTKD 684

Query: 2682 NMAIGKGE-QALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2740
                  G+ + L+ S  E QR +  +   ++    +   S V   +T    + +W     
Sbjct: 685  EAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQA- 743

Query: 2741 RKNQLEQWMESVDQ--KIEHPLQPQPGL------KEKFVLLDHLQSILSEAEDHTRALHR 2792
            R    +Q   S+ Q  ++E  L  Q  L      + + +L+ H     S AE    A  +
Sbjct: 744  RTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH-----SAAETSGDAGEK 798

Query: 2793 LIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMY------- 2845
                S+EL  + E  S +D  + + ++   +  T  K  ++ V E  ++ ++Y       
Sbjct: 799  PDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQK-LLQNVLEQEQEQVLYSRPNRLL 857

Query: 2846 --------------LDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSRE 2891
                            AV    D L+ A EE+   S  SG   A ++ +   ++L D   
Sbjct: 858  SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSG--GAKRQSIHLEQKLYDGVS 912

Query: 2892 IGASRLSRVE-------SLAPE------VKQNTTASGCELMHTEMQALRADWKQW----- 2933
              ++ L  VE       +L PE        Q   A   + M  EM   +  + Q      
Sbjct: 913  ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 972

Query: 2934 --EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQ---FSALLKTWAQQLT---- 2984
               D +  T  C   L+ +++L +   + +  Q+++ L+Q   F   LK     L     
Sbjct: 973  DNRDVIEDTLGC---LLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKY 1029

Query: 2985 --LLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
              L +  N  E+ V       E ++A+Q+AE   ++  + + EL R    L      +  
Sbjct: 1030 IILQKLANVFEQPV------AEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 1083

Query: 3043 LIK-----EYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFD-IPQN 3096
            L K     +   + + + +   N+   L+ ++ +A +D    L   +   A     I  +
Sbjct: 1084 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 1143

Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKN 3156
              E+   L K +E+    E+       +  K  ++S  + KE     +  +  A    K 
Sbjct: 1144 KEEIQQLLDKHKEYFQGLESHMILTETLFRK--IISFAVQKETQFHTEL-MAQASAVLKR 1200

Query: 3157 FHSNLHQKESALE---NLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ 3213
             H    + E  LE   +L    ++     E ++  +     +V E+ +RL D   +    
Sbjct: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV-GLVEENEDRLID---RITLY 1256

Query: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVS 3273
            Q L+S L E   Y+P+L ++ +  ++L    + S     +++QL   +L+ +N   +++ 
Sbjct: 1257 QHLKSSLNE---YQPKLYQVLDDGKRLLISISCS-DLESQLNQLGECWLSNTNKMSKELH 1312

Query: 3274 RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLK-----LEALLS 3328
            RL+ I+    ++     +L  W+  A   L+ +    + +SV   + L+     L A L 
Sbjct: 1313 RLETILKHWTRYQSESADLIHWLQSAKDRLEFW----TQQSVTVPQELEMVRDHLNAFLE 1368

Query: 3329 VKQEKEIQMKM---IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3385
              +E + Q  +   +++ G  +L+    +   T++ +L  +   W  LL+     + +L 
Sbjct: 1369 FSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWTDLLTNIPAVQEKLH 1427

Query: 3386 GALSKWTSYQDGVRQFSGWMDSMEANLNESERQ----------HAELR-------DKTTM 3428
                     +  + +   W+  ME  + + E            H  L+       D    
Sbjct: 1428 QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 1487

Query: 3429 LGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSE 3488
                  +N+ VL  SS  + +E K +  T+      +L  + + ++ +Q    E +   E
Sbjct: 1488 QLTVDFVNQSVLQISS--QDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKIQLLE 1542

Query: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ--VHCAE-- 3544
             L+    EY+ +++  + W   ++++L Q   + GD  + +  L+D Q+L+  +   E  
Sbjct: 1543 GLLESWSEYENNVQCLKTWFETQEKRLKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKE 1601

Query: 3545 ----GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKL 3600
                 Q  L  + + +EDV  S I  +    L  L Q W    H + + +    +V+++ 
Sbjct: 1602 VEKIEQNGLALIQNKKEDV--SSIVMS---TLRELGQTWANLDHMVGQLKILLKSVLDQW 1656

Query: 3601 RLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGA 3660
               +  F +++ +L  A   +S       +    ++Q+  ++   +++      +++ G+
Sbjct: 1657 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 1716

Query: 3661 RAQEILDESH--VNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEE----SESSL 3714
               ++L E H  V   +     ++  R+  LL ++ EQ++  +  +Q  +     S+   
Sbjct: 1717 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 1776

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
            S+       T++  K  AT  D  D   +   ++    LLK +      L    E GE+ 
Sbjct: 1777 STVQQQEDRTNELLK-AATNKDIADD-EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 1834

Query: 3775 VKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAE 3834
             + ++   A  ++ +     + L  L   + K+  +L+ G+   + F+   +AL  WI E
Sbjct: 1835 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 1894

Query: 3835 YQEILHVPE----------EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
             +EIL   +          + +ME  E K Q+ K+ S+        P +  + E G  L 
Sbjct: 1895 AEEILQGQDPSHSSDLSTIQERME--ELKGQMLKFSSM-------APDLDRLNELGYRL- 1944

Query: 3885 ELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
              + D  +K ++  L   +  + S   E    L++ +  H+ +  + +   ++L+Q   +
Sbjct: 1945 -PLNDKEIK-RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK 2002

Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI--GQCADHLQAKL 4002
            L       + + + + +Q   H+    E+   +  L+++ + G  L+  GQ  D  +  L
Sbjct: 2003 LAVE---ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 2059

Query: 4003 KQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ--PDLE 4060
            K      L    + +  +   AQ+    ++ ++++    ++  ++ + WL  V   P   
Sbjct: 2060 K------LTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSG 2113

Query: 4061 PSPQP-PLSRAEAIKQVKHFRA---LQEQARTYL------DLLCSMCDLSNASVKTTAKD 4110
                P PL +A  +     F+    L++Q    L       LL S    + A+++    +
Sbjct: 2114 LGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAE 2173

Query: 4111 IQQTEQTIEQKLVQAQN----LTQGW-----------EEIKHLKSELWIYLQDADQQLQN 4155
            IQ+  ++   +L + +     L + W           E+++  K +L   L D  ++L  
Sbjct: 2174 IQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHA 2233

Query: 4156 MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4215
             + R  ELE     N V    D + +L   + +++  I      +  + S  ++ +  L 
Sbjct: 2234 EQMRCKELE-----NAVGSWTDDLTQLSLLKDTLSAYI------SADDISILNERVELLQ 2282

Query: 4216 DQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLE--KFTTEWDNLARSDAESTAV 4273
             QW +LC Q   L L+R++  +R       +N   VF E  K   EW     S       
Sbjct: 2283 RQWEELCHQ---LSLRRQQIGER-------LNEWAVFSEKNKELCEWLTQMESKVSQNGD 2332

Query: 4274 HL--EALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL----VKEQTSHLEQRWFQ 4327
             L  E ++KL    QE     ++ K Q Q+M E L     E     ++ +   +  RW  
Sbjct: 2333 ILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQH 2392

Query: 4328 LEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL-KQSPPPDMAQNLLMD 4386
            L DLI  +++     L  +  +      L  W    +  +A+ +   S   +  Q  L +
Sbjct: 2393 LLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNE 2452

Query: 4387 HLAICSELEAKQM-------LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
               +  ++E           L + L+ D D    D    E   IQ+A  +       +  
Sbjct: 2453 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA---ECDSIQQATRNLDRRWRNICA 2509

Query: 4440 LVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA 4499
            +  +RR  + +      +FL    +    ++  ER   F     ++     +++K  ++ 
Sbjct: 2510 MSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAF 2569

Query: 4500 QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEK 4559
            Q  +     ++  +  Q R L +E        +   + E    +D++ ++ +  L+ L+ 
Sbjct: 2570 QRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKH 2629

Query: 4560 NLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY---E 4616
             +  R+ F+   D    WL + D+    ++  +   SE   Q AK + +     E     
Sbjct: 2630 FIGQREEFETARDSILVWLTEMDL----QLTNIEHFSECDVQ-AKIKQLKAFQQEISLNH 2684

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK------------DKFY 4664
            N +  +   G+ ++     +D + + E+L+ L R    +    +            D  +
Sbjct: 2685 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 2744

Query: 4665 KVQEAILARKEYASLIEL--------------TTQSLSELEAQFLRMSKVPTDL-AVEEA 4709
             + +  L  ++ A+L +L               + +LS   AQ LR  +   D  A  ++
Sbjct: 2745 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 2804

Query: 4710 LSLQ-----DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKR 4764
            + L+     D  R +   ++    + DE  Q  + F   G          L +   +L +
Sbjct: 2805 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGK 2864

Query: 4765 -------QTEQRVSLLEDTT-------SAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4810
                   Q +Q  +++   T       ++Y+ + K+  +    + SVK  + K+ EE   
Sbjct: 2865 ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE--- 2921

Query: 4811 AEEKLKMYHSL-AGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLT 4869
             EE L  + +L +   Q +G++ +   +  + L+  L      + +  +Q WQ       
Sbjct: 2922 -EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL------RMKQNLQKWQ------- 2967

Query: 4870 SAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL--NLQDIQEEIRKI 4927
                               F ++++    WL   + EL     L+L  ++Q I+ +I+K+
Sbjct: 2968 ------------------QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 3009

Query: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQAT 4987
            +  Q+ V     I+ +++    E FT+A    S DL+  L++++     +   L   +  
Sbjct: 3010 KELQKAVDHRKAIILSINLCSPE-FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 3068

Query: 4988 LTEIYSQCQRYYQVFQAANDWLED----AQELLQLAGNGLDVESAEENLKSHMEFFSTED 5043
            L +   QCQ ++++       LE+      E++ +  N LD E  +++ K  M+      
Sbjct: 3069 LQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN-LDAEILQDHHKQLMQIKHELL 3127

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLEQK 5074
            +    +  L  +   L  L+   G + LE K
Sbjct: 3128 ESQLRVASLQDMSCQL--LVNAEGTDCLEAK 3156



 Score =  171 bits (434), Expect = 2e-41
 Identities = 594/3328 (17%), Positives = 1269/3328 (38%), Gaps = 427/3328 (12%)

Query: 4187 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4246
            A+V   +E+  +L K    P  K+I  L +      RQ+ N   +  +      +Y++ +
Sbjct: 5    AAVQKFLEQNGQLGK----PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60

Query: 4247 NVVEVFLEKF------TTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4300
             ++  ++EK       T  W N A    E   +H          L+E K    +L+   +
Sbjct: 61   ELILKWIEKAKVLAHGTIAW-NSASQLREQYILH-------QTLLEESKEIDSELEAMTE 112

Query: 4301 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4360
            K+    ++   E + +Q + L +   +L  +IK ++Q      +++   ++  ++L    
Sbjct: 113  KLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAAL 172

Query: 4361 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4420
            E+ Q  +         P++ +  L + L+    L ++   LK  ++      + L + E 
Sbjct: 173  EQAQATLTS-------PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPED 225

Query: 4421 QVIQKALSDA----QSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4476
             V    L  A    Q   + L     Q+   +  A+ +  Q+   +      I+   R+I
Sbjct: 226  VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI 285

Query: 4477 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL---------WAQGRELMKEVTEQ 4527
              +        ++  Q+   +     +K YQ ++  L          A+   ++  VTE 
Sbjct: 286  EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345

Query: 4528 E-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD 4582
            E       ++ G+L    S + SV+   + R   L   +      +E  ++  +    + 
Sbjct: 346  EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT-----EESGEEGTNSEISSP 400

Query: 4583 IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-- 4640
                    + N  + ++  +A YQ +  +          LQ     I PS +     Y  
Sbjct: 401  PACRSPSPVANTDASVNQDIAYYQALSAE---------RLQTDAAKIHPSTSASQEFYEP 451

Query: 4641 -----LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS-ELEAQF 4694
                  + KL  L R +  +  +  +K   + EA+  +++Y      + QS+S ++EA  
Sbjct: 452  GLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD----SLQSISTKMEAIE 507

Query: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQK-KEGFRSTGQPWQPDKML 4753
            L++S+ P      E+   +   +A++DE+  L + ++EL     E   S      P + L
Sbjct: 508  LKLSESPEPGRSPESQMAEH--QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 565

Query: 4754 HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEE 4813
             L +    L     +R+S +    S  +      Q LE +L    EEQ +        E+
Sbjct: 566  ALQSTLTVL----AERMSTIRMKASGKR------QLLEEKLNDQLEEQRQ--------EQ 607

Query: 4814 KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4873
             L+ Y   A  L DS ++  + T+    L+P  +P+  E      Q+   E++    A+ 
Sbjct: 608  ALQRYRCEADEL-DSWLLSTKATLDTA-LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 665

Query: 4874 ETVTECESRMVQ-SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE 4932
            E     E+ +++     + E  +    LRR+K  L     L+L      +++      QE
Sbjct: 666  ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL-----LELQRALHDKQLNMQGTAQE 720

Query: 4933 EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIY 4992
            + +S + +    S   +E   +A+   +   + SL +  EL+ ++ E    +++ L  + 
Sbjct: 721  KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE----QKSLLRSVA 776

Query: 4993 SQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEEL 5052
            S+ +       AA        E    AG   DV S E  ++   E  S EDQ     E L
Sbjct: 777  SRGEEILIQHSAA--------ETSGDAGEKPDVLSQELGMEG--EKSSAEDQMRMKWESL 826

Query: 5053 HSLVATLDPLIKPTGKEDLEQKVASLELR---------SQRMSRDSGAQVDLLQRCTAQW 5103
            H   +T   L++   +++ EQ + S   R             ++D  A   LL      +
Sbjct: 827  HQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAF 886

Query: 5104 HDYQK----AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS---FH 5156
             +       A+ + I L    E+KL +     ++   + EE+L    AL+        F+
Sbjct: 887  EEVSSQSGGAKRQSIHL----EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFN 942

Query: 5157 EKIVA--LEEKASQLEKTGNDASKA---------TLSRSMTTVWQRWTRLRAVAQDQEKI 5205
            ++I+A  ++E + +++K  N  S+A          +  ++  +  R + L +V   +   
Sbjct: 943  QEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ 1002

Query: 5206 LEDAVDEWTGFNNKVKKA-TEMIDQ----LQDKLPGSSAEKASKAELLTL----LEYHDT 5256
            +++ + +   F N +K   T + D     LQ          A + E +      L+  D 
Sbjct: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062

Query: 5257 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5316
             ++EL+++   L +                   E P MQE++ +QD    +   + +   
Sbjct: 1063 GIIELKRRGDKLQV-------------------EQPSMQELSKLQDMYDELMMIIGSRRS 1103

Query: 5317 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK 5376
             + Q L  +   E  +  +   ++  +E +      I +  EE+Q LL +   + Q +E 
Sbjct: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163

Query: 5377 ---MAEEQKEKYLGL----YTILPSELSLQLAEVALDLKIRDQIQDKIKEV-EQSKATSQ 5428
               + E    K +       T   +EL  Q + V      R    + I E         Q
Sbjct: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223

Query: 5429 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLME-LDAAVQKFL 5487
            ELSRQ++ +   + ++   ++   D ++   T  + L   L+    KL + LD   +  +
Sbjct: 1224 ELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282

Query: 5488 EQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK 5547
              +      L  ++ +L E       +    L +L     H   Y      ++ W++ AK
Sbjct: 1283 SIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAK 1339

Query: 5548 -VLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 5605
              L   T    +  Q  E    H    LE SKE+D++    +  L     +   +K+   
Sbjct: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV--D 1397

Query: 5606 VAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPE----VG 5661
             A L  E   +       L N+    + + + + +    + A+ +  + ++  E      
Sbjct: 1398 TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD 1457

Query: 5662 RLSLKEQLSHR--QHLLSEMESLKPKVQAVQLC-----QSALRIPEDVVAS-----LPLC 5709
              ++K  + ++     L + +  K  +   QL      QS L+I    V S         
Sbjct: 1458 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517

Query: 5710 HAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5769
                 + +    LQ    ++  +++  +  + +YE  ++ L+   E   + ++ +     
Sbjct: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH-RIG 1576

Query: 5770 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5829
            +   +Q  +   ++L   IK  ++++  +      L    K     + ++ +  L +   
Sbjct: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636

Query: 5830 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE-SGEEGTNSEISS--PPACRSPSPVA 5886
            +LD                  G+   LL  V ++ S  +    +I+S    A  S S   
Sbjct: 1637 NLD---------------HMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR 1681

Query: 5887 NTDASVNQDIAYYQALSAERLQTDAAKIHPS-------TSASQEFYEPGLEPSATAKLGD 5939
                S+  +    Q  + + LQ D  K   S       T+   +   P +  + T  L +
Sbjct: 1682 LLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 1739

Query: 5940 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
            +   W  L   I+E+ ++    L+  Q+Y+D  +  ++ ++  E + +E  +   + +  
Sbjct: 1740 VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIA 1799

Query: 6000 MAEHQALMDEILMLQDEINELQSSL--AEELVSE-SCEADPAEQLALQSTLTVLAERMST 6056
              E    + +   L   +  ++ SL    EL  +   + D +   A+QS    L++ +  
Sbjct: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859

Query: 6057 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 6116
            +      ++  L+  + D     +  +AL+ +  EA+E+   L     +  + LS  +E 
Sbjct: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEI---LQGQDPSHSSDLSTIQER 1916

Query: 6117 M-DMEAQLMDCQNMLVEIEQKVVALSELSVHNENL--LLEGKAHTKDEAEQLAGKLRRLK 6173
            M +++ Q++   +M  ++++       L ++++ +  +     H    + Q   +  +L+
Sbjct: 1917 MEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976

Query: 6174 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6233
              LL+ Q  L   +  M+   Q +++  V++    S   Q  L Q R             
Sbjct: 1977 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI----SGNYQHLLEQQRA------------ 2020

Query: 6234 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6293
             +  + E+  ++ +L S+   G+  L++    +   +   K  +LS +            
Sbjct: 2021 HELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKLTLLSNQ------------ 2067

Query: 6294 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL----LSGVPLY-KGDVPTQDK 6348
                 W+ + +    ++ ++ + + Q Q     +   R     +S +P+   G VP   +
Sbjct: 2068 -----WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 2122

Query: 6349 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY-----DGVSATSTWLDDVEERLFV 6403
             A T L D + Q  E+V  +  G+   ++   ++L         +A    L +++E+   
Sbjct: 2123 QART-LFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKS 2180

Query: 6404 ATALLPEETETCLF---NQEILAKDIKEMSEEMDKNKNLFSQAFPENGD----------- 6449
            A+  L E+ +   F   + E   K I +  E++   K   SQ+ P++ +           
Sbjct: 2181 ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE 2240

Query: 6450 -------------NRDVIEDTLGCLLG---------RLSLLDSVVNQRCHQMKERLQQIL 6487
                            +++DTL   +          R+ LL     + CHQ+  R QQI 
Sbjct: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300

Query: 6488 NFQND--------------LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6533
               N+              L  + + ++ N  I+++++    ++   E+I   Q+ +  L
Sbjct: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQL 2360

Query: 6534 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6593
            ++    + +        ++E     +L K+ D +  L+ +I +R   L + L    Q ++
Sbjct: 2361 QQMGERLAKASHESKASEIE----YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK 2416

Query: 6594 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTET 6646
             +  L   L   + ++A        + EEIQ+ L++ +E  + +E H       + L E 
Sbjct: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476

Query: 6647 LFRKIISFAVQKE----TQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLD-----E 6696
            L     + A   E     Q    L  +   +   + +R +++E     W   LD     E
Sbjct: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536

Query: 6697 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6756
            D  + S +     SS   +  V + E +  +      H   +  E   K Y+ L    R 
Sbjct: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR- 2595

Query: 6757 LISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKD 6816
              + S   L+  +++  + W +   +++  L RL+  +     +++    ++ WL     
Sbjct: 2596 --TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 2653

Query: 6817 RLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTA 6875
            +L      ++    E + V+  +     F +E+    +    +++ G QL+ + + +D A
Sbjct: 2654 QL-----TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 2707

Query: 6876 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMD-----------KLPSRHAISEVMSWIS 6924
             +  EL  +     ++   +    +KL +L +            +L    A+S+ + W  
Sbjct: 2708 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-LHWHD 2766

Query: 6925 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 6984
               + +   + +  +++          +  G     +   + +++ +   L   S+D+ES
Sbjct: 2767 RSADSLLSPQPS--SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL---SRDLES 2821

Query: 6985 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 7044
              S      ++ G  +K +  L+G V        GL    S  E+ ++ L    +    +
Sbjct: 2822 AMSRALPSEDEEGQDDKDF-YLRGAV--------GLSGDHSALESQIRQLGKALDDSRFQ 2872

Query: 7045 LKQQHRI------------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQ 7090
            ++Q   I                     L +C    D +K  E ++++ E++  G   + 
Sbjct: 2873 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 2932

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
            + +   + ++          W  L       ++ +K  L +W       + I ++L +  
Sbjct: 2933 STETQTAGVI--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984

Query: 7151 YSLSRFRL--LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
              L + +   L+  ++ +++Q+  L+ LQ  ++ ++  +    ++ +    +     +  
Sbjct: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRD 3043

Query: 7209 LTNTLKEVNMRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7265
            L + L ++N RW+   +LLEE    LQ   AL+Q  Q + + S      ++  + R NE+
Sbjct: 3044 LQDRLSQMNGRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEI 3100

Query: 7266 LKAATNKD--IADDEVATWIQDCNDLLK 7291
            +   +N D  I  D     +Q  ++LL+
Sbjct: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLE 3128



 Score =  155 bits (391), Expect = 2e-36
 Identities = 476/2589 (18%), Positives = 980/2589 (37%), Gaps = 324/2589 (12%)

Query: 2960 GQVAQL-EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
            G++ +L +Q + Q    L    Q  + LE  N   E++  W +  ++L     A      
Sbjct: 26   GKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ 85

Query: 3019 LKSQ-------LNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRK 3071
            L+ Q       L E      +L   + K+  L   Y          C  K   + Q+  +
Sbjct: 86   LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY----------CTEK---MSQQVAE 132

Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSES-------ENGQHKLNMM 3124
              R+ ++     KI      D  +++ +    L+K+Q  L ++       E G+  L   
Sbjct: 133  LGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQ 192

Query: 3125 LS-KGELLSTLLT-KEKAKGIQAKVTAAK--ED----WKNFHSNLHQKESA--LENLKIQ 3174
            LS +  LLS + + K K + +Q   +A +  ED        H+ L  +E A  L++  IQ
Sbjct: 193  LSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQ 252

Query: 3175 ----MKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230
                M+   V  E  +  +   ++++  +   + D P      Q+LQ+          Q+
Sbjct: 253  QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA----------QI 302

Query: 3231 NRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIK 3290
            +R +E AQ++       K ++ +++ L+S+   L+   K     L   V E    + G +
Sbjct: 303  SRHEELAQKI-------KGYQEQIASLNSKCKMLTMKAKHATMLLT--VTEVEGLAEGTE 353

Query: 3291 ELQDWM--TDAIH-----MLDSYCH----PTSDKSVLDSRTLKLEAL------------- 3326
            +L   +  T + H     M    CH    P +++S  +    ++ +              
Sbjct: 354  DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTD 413

Query: 3327 LSVKQE----KEIQMKMIVTRGESVLQNTS-------PEGIPTIQQQLQSVKDMWASLLS 3375
             SV Q+    + +  + + T    +  +TS       P   P+   +L  ++  W +L +
Sbjct: 414  ASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKN 473

Query: 3376 AGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ----HAELRDKTTMLGK 3431
                 +  L  AL +   YQD ++  S  M+++E  L+ES        +++ +   ++ +
Sbjct: 474  VISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDE 533

Query: 3432 AKLLNEEVLSY-SSLLETI--EVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSE 3488
              +L +E+    SSL E +  E   A   E    Q  L  L ER   I+ +A       E
Sbjct: 534  ILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 593

Query: 3489 KLVRLHQEYQRDLKAFE----------VWLGQEQEKLDQYSVLEGDAHTHETTLRDLQEL 3538
            + +    E QR  +A +           WL   +  LD       +    E  L D Q +
Sbjct: 594  EKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNM 653

Query: 3539 QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA------LESLRQDWQAYQHRLSETRTQ 3592
             V   +    L+ +    E+++  G    +D A      L  L+      Q  L + +  
Sbjct: 654  LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLN 713

Query: 3593 FNNVVNK-----LRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEE 3647
                  +     + L   +   V EWL  A+ + +   +RQS+       L Q K+  +E
Sbjct: 714  MQGTAQEKEESDVDLTATQSPGVQEWL--AQARTTWTQQRQSS-------LQQQKELEQE 764

Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3707
            +   +  +  V +R +EIL +       G                  E+   L +E+   
Sbjct: 765  LAEQKSLLRSVASRGEEILIQHSAAETSGDAG---------------EKPDVLSQELGME 809

Query: 3708 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKS- 3766
             E  S+       + S H+ F   +TK   +  V+  ++ + L      +  G  L K  
Sbjct: 810  GEKSSAEDQMRMKWESLHQEF---STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGD 866

Query: 3767 AREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCK 3826
               + + AV  L +G        ++   E++   +   +++       +HL ++  D   
Sbjct: 867  VPTQDKSAVTSLLDG--------LNQAFEEVSSQSGGAKRQ------SIHLEQKLYDGVS 912

Query: 3827 ALTQWIAEYQEILHV-----PEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGE 3881
            A + W+ + +E L V     PEE +  L+ ++      K + + +  ++        +  
Sbjct: 913  ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 972

Query: 3882 ALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLL 3939
               ++++D    L  ++  L S     C   KE +  +     D +   + L + +  +L
Sbjct: 973  DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 1032

Query: 3940 QMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3999
            Q    +    + E   +E I Q         + +  F+  +  L+ +GD L         
Sbjct: 1033 QKLANVFEQPVAE--QIEAIQQA-------EDGLKEFDAGIIELKRRGDKL--------- 1074

Query: 4000 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 4059
             +++Q     L   +D Y  +          L   L      +  LQ     L   Q  +
Sbjct: 1075 -QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKM 1133

Query: 4060 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4119
                +  +S  E I+Q+     L +    +  L   M        K  +  +Q+  Q   
Sbjct: 1134 AGDQKIIVSSKEEIQQL-----LDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHT 1188

Query: 4120 QKLVQAQNLTQGWE----EIKHLKSELWIYLQDADQQLQNMKR--RHSELELNIAQNMVS 4173
            + + QA  + +       E++++  E W +L +  Q+L         S   + + +    
Sbjct: 1189 ELMAQASAVLKRAHKRGVELEYIL-ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 1247

Query: 4174 QVKDFVKKLQSKQASVNTIIEKVNKLTKKEE--------SPEHKEINHLNDQWLDLCRQS 4225
            ++ D +   Q  ++S+N    K+ ++    +        S    ++N L + WL    + 
Sbjct: 1248 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKM 1307

Query: 4226 NNLCLQREEDLQRTRDYH----DCMNVVEVFLEK--FTTEWDNLARSDAESTAVHLEALK 4279
            +    + E  L+    Y     D ++ ++   ++  F T+       + E    HL A  
Sbjct: 1308 SKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFL 1367

Query: 4280 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVS 4339
            + +  +  +      +     +++    +D   L + + S ++ +W  L   I   +Q  
Sbjct: 1368 EFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL-RSELSRIDSQWTDLLTNIPA-VQEK 1425

Query: 4340 VTNLEELNVVQSR--FQELMEWAEEQQPNIA---EALKQSPPPDMAQNLLMDHLAICSEL 4394
            +  L+ ++ + SR    E+M W    +  I    + +K S         L  +     ++
Sbjct: 1426 LHQLQ-MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 1484

Query: 4395 EAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSE 4454
              KQ+ +  + +   ++ +       Q ++   SD       L  +  +  + L   ++E
Sbjct: 1485 NCKQLTVDFVNQSVLQISS-------QDVESKRSDKTDFAEQLGAM-NKSWQILQGLVTE 1536

Query: 4455 KTQFLMAVFQATSQIQQH----------ERKIMFREHICLLPDDVSKQVKTCKSAQASLK 4504
            K Q L  + ++ S+ + +          + K + ++H       V   +K C+  +  +K
Sbjct: 1537 KIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIK 1596

Query: 4505 TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4564
              + EV  +   G  L++   E   S V+  L+EL   + + L     +L+ L K+++ +
Sbjct: 1597 AKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN-LDHMVGQLKILLKSVLDQ 1655

Query: 4565 -KHFKEDFDKACHWLKQADIVTFPEINLMNESSE-LHTQLAKYQNILEQSPEYENLLLTL 4622
                K  FDK   +L +A   +     L+  S E +  Q+   QN+ +   + E  L   
Sbjct: 1656 WSSHKVAFDKINSYLMEARY-SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 1714

Query: 4623 QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIEL 4682
                  +L   +      L+  L  +  ++N ++    ++    +  +   + Y    + 
Sbjct: 1715 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 1774

Query: 4683 TTQSLSELEAQFLRMSKVPT--DLAVEEALSLQDGCRAILDEVAGLGEAVDEL------- 4733
               ++ + E +   + K  T  D+A +E  +    C  +L    GLG   D L       
Sbjct: 1775 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLK---GLGTVKDSLFFLHELG 1831

Query: 4734 -NQKKEGFRSTGQPWQPDKML---HLVTLYHRL-KRQTEQRVSLLEDTTSAYQEHEKMCQ 4788
               K++   S     Q D++    HL  L   L K+QT  +  +L+     Y+   K  +
Sbjct: 1832 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD-----YETFAKSLE 1886

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
             LE  +           EE L  ++    + S   ++Q+    LK   +    +AP LD 
Sbjct: 1887 ALEAWIVEA--------EEILQGQDP--SHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 1936

Query: 4849 L--------AYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWL 4900
            L          +K   ++Q+      L++S   E  ++ +S ++Q   F  +    +++L
Sbjct: 1937 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFL 1996

Query: 4901 RRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELIS 4960
             + + +L+  V +  N Q + E+ R  ++ Q E+ S  +I++++    +    + +    
Sbjct: 1997 VQTEQKLA--VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDR 2054

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 5020
             +    L  LS     +    + R+  +     Q QRY ++ +    WL +    L ++G
Sbjct: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-YLPMSG 2113

Query: 5021 NGLDVESAEENLKSHMEFFSTEDQFHSN--LEELHSLVATLDP-----LIKPTGKED-LE 5072
             G    S    L+     F  E QF     L +  S + T++      L   +G E  L+
Sbjct: 2114 LG----SVPIPLQQARTLFD-EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 2168

Query: 5073 QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKT 5132
             ++A ++ + +  S     Q   L      W   +K   + +E +   +KKLS+ SL   
Sbjct: 2169 AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQ-SLPDH 2227

Query: 5133 SSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRW 5192
                 AE+     K L + V S+ + +  L      L    +    + L+  +  + ++W
Sbjct: 2228 HEELHAEQMRC--KELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285

Query: 5193 TRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE 5252
              L      + + + + ++EW  F+ K K+  E + Q++ K+       +   ++L    
Sbjct: 2286 EELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV-------SQNGDILI--- 2335

Query: 5253 YHDTFVLELEQQ-QSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEIT----AMQDRCLNM 5307
              +  + +L++  Q  + + ++  + + Q G             EI      + DR  ++
Sbjct: 2336 --EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHL 2393

Query: 5308 QEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEA 5367
             + +    K +K+ L   + ++  ++S++ W+   +  L  P +      EE+Q  L E 
Sbjct: 2394 LDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQ 2453

Query: 5368 TNHRQNIEK 5376
               +++IEK
Sbjct: 2454 QELQRDIEK 2462



 Score =  132 bits (333), Expect = 1e-29
 Identities = 621/3292 (18%), Positives = 1212/3292 (36%), Gaps = 545/3292 (16%)

Query: 3679 ATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
            A+QL  +Y  L   +LE+ K ++ E++++ E    L+S       T K  + VA    + 
Sbjct: 83   ASQLREQY-ILHQTLLEESKEIDSELEAMTEKLQYLTSVY----CTEKMSQQVAELGRET 137

Query: 3739 DTV--MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERL--------RK 3788
            + +  M+  +L+ L+   KDM+K  + LK  +   E+A   L   E  RL        R+
Sbjct: 138  EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQ 197

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE-------------KGLHLAKEFS-------DKCKAL 3828
             +   ME LK     V+     L                L L +E S        +C  +
Sbjct: 198  HLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIM 257

Query: 3829 TQWIAEY----QEILHVPE---------EPK----MELYEKKAQLSKYKSLQQTVLSHEP 3871
               + +Y    QE+ H+ +         E K      + E +AQ+S+++ L Q +  ++ 
Sbjct: 258  QAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 317

Query: 3872 SVKSVREKGEALLELVQDVTLK---DKIDQLQSDYQDL----------------CSIGKE 3912
             + S+  K + L    +  T+     +++ L    +DL                 + G+ 
Sbjct: 318  QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC 377

Query: 3913 H-VFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME 3971
            H + S   +    E  NSE+          + R  +P     +S   + Q +A+++A+  
Sbjct: 378  HTLLSPVTEESGEEGTNSEISSPP------ACRSPSPVANTDAS---VNQDIAYYQALSA 428

Query: 3972 EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL 4031
            E      RL     K         +  +  L+ +  A L   + S+  + +      ++L
Sbjct: 429  E------RLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL 482

Query: 4032 EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE------- 4084
               L++    QD+LQ     + A++  L  SP+P   R+   +  +H   + E       
Sbjct: 483  YEALERQQKYQDSLQSISTKMEAIELKLSESPEP--GRSPESQMAEHQALMDEILMLQDE 540

Query: 4085 ----QARTYLDLLCSMCDLSNAS--------------VKTTAKDIQQTEQTIEQKL---V 4123
                Q+    +L+   C+   A               + T         Q +E+KL   +
Sbjct: 541  INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600

Query: 4124 QAQNLTQGWEEIKHLKSEL--WIYLQDA--DQQLQNMKR-RHSELELNIAQNMVSQVKDF 4178
            + Q   Q  +  +    EL  W+    A  D  L   K     E +L   QNM+ +++  
Sbjct: 601  EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
            V  L         ++ +    TK E      ++  L    L+L R  ++  L  +   Q 
Sbjct: 661  VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720

Query: 4239 TRDYHDCMNV-----VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIE 4293
              +    +       V+ +L +  T W    +S        L+  K+L   L E+K  + 
Sbjct: 721  KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS-------LQQQKELEQELAEQKSLLR 773

Query: 4294 DLKDQKQK-MIEHL------NLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4346
             +  + ++ +I+H       +  +K  V  Q   +E      ED ++ K +   +  +E 
Sbjct: 774  SVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE---SLHQEF 830

Query: 4347 NVVQSRFQELMEWAEEQ----QPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLK 4402
            +  Q   Q ++E  +EQ    +PN    L    P         D  A+ S       LL 
Sbjct: 831  STKQKLLQNVLEQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTS-------LLD 880

Query: 4403 SLIKDADRVMADLGLNERQVI--QKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT---- 4456
             L +  + V +  G  +RQ I  ++ L D  S  +   D V +R       L E+T    
Sbjct: 881  GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 940

Query: 4457 --QFLMAVFQATSQIQQHERKIMFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTG 4512
              Q ++A        +  + K +F +      D  DV +    C   + SL    + V  
Sbjct: 941  FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSL--LDSVVNQ 998

Query: 4513 LWAQGRELMKEVTE-QEKSEVLGK---------LQELQSVYDSVLQKCSHRLQELEKNLV 4562
               Q +E ++++   Q   +VL           LQ+L +V++  + +    +Q+ E  L 
Sbjct: 999  RCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL- 1057

Query: 4563 SRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTL 4622
                  ++FD     LK+       E   M E S+L     +   I+       N  LTL
Sbjct: 1058 ------KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111

Query: 4623 ----QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY---KVQEAILARKE 4675
                +R  Q +   L         ++   +  +  +   L K K Y        IL    
Sbjct: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 1171

Query: 4676 YASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQ 4735
            +  +I    Q  ++   + +  +      A +  + L+     IL+  + L E   EL++
Sbjct: 1172 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE----YILETWSHLDEDQQELSR 1227

Query: 4736 KKEGFRSTGQ-----PWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK----- 4785
            + E   S+           D+++  +TLY  LK       SL E     YQ  +      
Sbjct: 1228 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKS------SLNEYQPKLYQVLDDGKRLL 1281

Query: 4786 ---MCQQLERQLKSVKE----EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4838
                C  LE QL  + E      +K+++E    E  LK +        D    L+     
Sbjct: 1282 ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDR 1341

Query: 4839 LEDLAPH--LDPLAYEKARHQIQSWQGELKLL--TSAIGETVTECESRMVQSIDFQTEMS 4894
            LE         P   E  R  + ++    K +   S++  +V    +++++     T   
Sbjct: 1342 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 1401

Query: 4895 RSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ-------EEVQSSLRIMNALSHK 4947
            RS   L R+ ++ +    L  N+  +QE++ ++Q+ +        EV S + +M  +  K
Sbjct: 1402 RS--ELSRIDSQWTD---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQK 1456

Query: 4948 EKEKFTKA----------------------KELISADLEHSLAELSELDGDIQEALRTRQ 4985
            +++    +                      K+L    +  S+ ++S  D    E+ R+ +
Sbjct: 1457 DEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD---VESKRSDK 1513

Query: 4986 ATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA-EENLKSHMEFFSTEDQ 5044
                E      + +Q+ Q          E +QL    L+  S  E N++    +F T+++
Sbjct: 1514 TDFAEQLGAMNKSWQILQGL------VTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 1567

Query: 5045 FHSNLEELHSL------------VATLDPLIKPTGKE-------------DLEQKVASLE 5079
                L++ H +               L+ LIK   KE             + ++ V+S+ 
Sbjct: 1568 ---RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIV 1624

Query: 5080 LRSQRMSRDSGAQVD--------LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLK 5131
            + + R    + A +D        LL+    QW  ++ A +++   + +    LS F LL 
Sbjct: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL- 1683

Query: 5132 TSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQR 5191
            T S    + ++   + L   +      +       +QL K  +     TL+ ++  V  R
Sbjct: 1684 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 1743

Query: 5192 WTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDK----LPGSSAEKASKAEL 5247
            W  L     +Q +  +  +  W  + +  K+    + Q +D+    L  ++ +  +  E+
Sbjct: 1744 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 1803

Query: 5248 LTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DGAAPTPGEEPPLMQEITAMQDR 5303
             T ++  +  +  L   + +L  L +    + Q      A+    ++  L Q + A++  
Sbjct: 1804 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 1863

Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQIL 5363
                Q  ++         + D E     + +++ W+ E +E L        + L  +Q  
Sbjct: 1864 LCKQQTSLQAG-------VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQ-- 1914

Query: 5364 LTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQ- 5422
                       E+M EE K + L   ++ P +L  +L E+   L + D+   +++ + + 
Sbjct: 1915 -----------ERM-EELKGQMLKFSSMAP-DLD-RLNELGYRLPLNDKEIKRMQNLNRH 1960

Query: 5423 -SKATSQELSR--QIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMEL 5479
             S  +SQ   R  ++Q       T L K +   + +VQ  T+QK L  E+ G    L+E 
Sbjct: 1961 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQ--TEQK-LAVEISGNYQHLLEQ 2017

Query: 5480 DAAVQKF--------------------LEQNGQLG--KPLAKKIGKLTELHQQTIRQAEN 5517
              A + F                    L + GQ+        K+  L+   Q  IR+A+ 
Sbjct: 2018 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ 2077

Query: 5518 RLSKLNQAASHLEEYNEMLELILKWIEKAKVL-----------------AHGTIAWNSAS 5560
            R   ++      + Y EM E + KW+ +   L                     + +    
Sbjct: 2078 RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137

Query: 5561 QLREQ--YIL-----HQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET 5613
             LR+Q  YIL      Q LL      ++ L+A   ++Q        EK       L  + 
Sbjct: 2138 FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ--------EKWKSASMRLEEQK 2189

Query: 5614 EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQ 5673
            ++L  ++K   +  +  A  ++K     KKL  +L      L + ++    L+  +    
Sbjct: 2190 KKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWT 2249

Query: 5674 HLLSEMESLKPKVQAVQLCQSALRIPEDVVASL-----PLCH-AALRLQEEASRLQHTAI 5727
              L+++  LK  + A  +    + I  + V  L      LCH  +LR Q+   RL   A+
Sbjct: 2250 DDLTQLSLLKDTLSA-YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308

Query: 5728 QQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 5787
                           + ++ K L + +     ++E K     +I          EE+ +K
Sbjct: 2309 ---------------FSEKNKELCEWL----TQMESKVSQNGDI--------LIEEMIEK 2341

Query: 5788 I-KGYQEQIA-SLNSKCKMLTM-----KAKHATMLLTVTEVEGLAEGTEDLDGELLPTPS 5840
            + K YQE+IA +  +K ++  M     KA H +     +E+E       D    LL   +
Sbjct: 2342 LKKDYQEEIAIAQENKIQLQQMGERLAKASHES---KASEIEYKLGKVNDRWQHLLDLIA 2398

Query: 5841 AHPSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEISSP---PACRSP--SPVANTDASVNQ 5894
            A    +  T      L   ++   +      SE++ P    +C S       N    + +
Sbjct: 2399 ARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 2458

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEK 5954
            DI  +    A  L      +H   + + +     ++ +      +L R W  +  +  E+
Sbjct: 2459 DIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR----NLDRRWRNICAMSMER 2514

Query: 5955 QRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG------RSPESQMAEHQALMD 6008
            +  + E     QK+ D        +++ E   +     G      +    +    Q  + 
Sbjct: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574

Query: 6009 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 6068
            E L   + IN+    LA E  ++S         +L+  +    +R   ++ + +   + L
Sbjct: 2575 ECLTQLELINKQYRRLARENRTDSA-------CSLKQMVHEGNQRWDNLQKRVTSILRRL 2627

Query: 6069 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6128
            +  +      QR+E     +    D +  WL  T+  L           D++A++   + 
Sbjct: 2628 KHFIG-----QREE-----FETARDSILVWL--TEMDLQLTNIEHFSECDVQAKIKQLKA 2675

Query: 6129 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6188
               EI      + ++    E L+ + +       E+   +LRR    +       H K +
Sbjct: 2676 FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI 2735

Query: 6189 NMQGTAQEKEESDVDLTATQSPGVQE--WLAQARTTWTQQRQSSLQQQKELEQELAEQKS 6246
             +     E + SD +L    S  + +  W  ++  +    + SS      L Q L  ++S
Sbjct: 2736 RLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSERS 2794

Query: 6247 LLRSVASRG----------------EEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSS 6290
               + AS                  E  + +   +E      +K   L   +G+ G+ S+
Sbjct: 2795 GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSA 2854

Query: 6291 AEDQMRMKWESL-HQEFSTKQKLLQNVLEQEQE------------QVLYSRPNRLLSGVP 6337
             E Q+R   ++L    F  +Q   +N++  +                L    +  +  V 
Sbjct: 2855 LESQIRQLGKALDDSRFQIQQ--TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 2912

Query: 6338 LYKGDVPTQDKS--------AVTSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDG 6386
              +  +  +++S        +  +   G+   +E + +Q+   +   +Q++   Q+    
Sbjct: 2913 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 2972

Query: 6387 VSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNK------NLF 6440
            +++   WL D EE L     L   E  T +   E+  K +KE+ + +D  K      NL 
Sbjct: 2973 LNSIWAWLGDTEEELEQLQRL---ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 3029

Query: 6441 SQAF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF---QNDLKV 6495
            S  F   ++ ++RD ++D L  + GR   + S++ +    +++ L Q   F    + L +
Sbjct: 3030 SPEFTQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 3088

Query: 6496 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP 6555
            +  ++   K  I+   +N+  + + +  + + Q +  L E    +  L+    +L V   
Sbjct: 3089 MLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAE 3148

Query: 6556 SMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
                L   + ++     +IG+R   L   L   S++ + L+ L D+  + Q+
Sbjct: 3149 GTDCLEAKEKVH-----VIGNR---LKLLLKEVSRHIKELEKLLDVSSSQQD 3192



 Score =  126 bits (317), Expect = 8e-28
 Identities = 548/3098 (17%), Positives = 1187/3098 (38%), Gaps = 401/3098 (12%)

Query: 1236 QYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQ 1295
            QY++ +K+ L++LI G+   +E  +K + T N+ E Q  +  H++  ++I    +  Q+Q
Sbjct: 266  QYEQEMKH-LQQLIEGAH--REIEDKPVATSNIQELQAQISRHEELAQKI----KGYQEQ 318

Query: 1296 IAQAQQGEGGLPDRG-HEELRKLESTLDGLERSRERQERRI--------QVTLRKWERFE 1346
            IA        L  +  H  +    + ++GL    E  +  +         V +    R  
Sbjct: 319  IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 378

Query: 1347 TNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA----VQAENLVKE 1402
            T    V     + G++ E     SS  +  S        +   + IA    + AE L  +
Sbjct: 379  TLLSPVTEESGEEGTNSE----ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 434

Query: 1403 ASEI----------------PLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
            A++I                P        LQ+  +++K  + + + TL E ++  +  + 
Sbjct: 435  AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494

Query: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEE 1506
                  +  E + + ++E  +   + E+  +     + +I +   EI    SS   L EE
Sbjct: 495  SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS---LAEE 551

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHA----QCLEGTILGHLSQQQKFEENLR 1562
              S +      E   +++ LT +      +R  A    Q LE  +   L +Q++ E+ L+
Sbjct: 552  LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQ-EQALQ 610

Query: 1563 KIQQSVSEFEDKL----AVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARK 1618
            + +    E +  L    A      S   E   +  + MD    L  +   + A S  +  
Sbjct: 611  RYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELS-- 668

Query: 1619 VVNRDSCVQEAAALQQQYEDI---LRRAK----ERQTALENLLAHWQRL--EKELSSF-L 1668
            V N +  ++  A  + + E +   LRR K    E Q AL +   + Q    EKE S   L
Sbjct: 669  VHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDL 728

Query: 1669 T---------WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQL 1719
            T         WL +     +         + ++E EL   ++L   V S+          
Sbjct: 729  TATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA 788

Query: 1720 KESLFSVASKDDVKMMKLHLE--------QLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
             E+      K DV   +L +E        Q+  +W  L Q  + +   LQ+V+ + Q+  
Sbjct: 789  AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQE-- 846

Query: 1772 ELLLS----FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHL 1827
            ++L S        + L+  ++ T  + ++      L +  +   EV S+ G  +    HL
Sbjct: 847  QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFE---EVSSQSGGAKRQSIHL 903

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
             +    G +     L    E   +LF   + + E  +  L +     +    +S  + + 
Sbjct: 904  EQKLYDGVSATSTWLDDVEE---RLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960

Query: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
            +         N +  D+IE  L   L     L+S        + +    +    ++ +  
Sbjct: 961  KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020

Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
              + AD     ++++ N+   +Q  A+ +  +++A +D  +E    I +++ R DK +++
Sbjct: 1021 FTSLADNKYIILQKLANVF--EQPVAEQIEAIQQA-EDGLKEFDAGIIELKRRGDKLQVE 1077

Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHEL---CWLKDKAKQIAQKDVAFAPEVDREINRLE 2064
            +P+ Q L +   ++++L   + S    L     LK + ++  Q D+A   E  +E    +
Sbjct: 1078 QPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ-DLADLLETGQE----K 1132

Query: 2065 VTWDDTKRLIHENQGQCCGLIDLMREY-QNLKSAVSKVLENASSVIVTRTTIKDQEDLKW 2123
            +  D  +++I  ++ +   L+D  +EY Q L+S +  + E     I++    K+ +    
Sbjct: 1133 MAGD--QKIIVSSKEEIQQLLDKHKEYFQGLESHMI-LTETLFRKIISFAVQKETQFHTE 1189

Query: 2124 AFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSE 2183
              ++      + + +  +L+       HL  + +++ S    +V++ + S          
Sbjct: 1190 LMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL-SRQLEVVESSIPSV--------G 1240

Query: 2184 KLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE 2243
             +EEN DRL   ++++  + S+ +E +      +      + ++       +L +  E  
Sbjct: 1241 LVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECW 1300

Query: 2244 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2303
            + N     +ELH     LK  T+        Q   ADL+  L+ AK+  E          
Sbjct: 1301 LSNTNKMSKELHRLETILKHWTR-------YQSESADLIHWLQSAKDRLEFWTQQSVTVP 1353

Query: 2304 AQSTQVEKFINDITTWFTKVE-ESLMNCAQNETCEALKKVKDIQKE-LQSQQSNISSTQE 2361
             +   V   +N    +  +V+ +S +  +   T   L ++K +    L+S+ S I S   
Sbjct: 1354 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWT 1413

Query: 2362 ----NLNSLCRKYHSAELESLG--RAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSES 2414
                N+ ++  K H  +++ L    A++ ++     +  +  K + +++ S+  K   E 
Sbjct: 1414 DLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEY 1473

Query: 2415 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
            +Q+++ + +      K+ +    +  VL+    D+++     +D   +L A+ +  Q L 
Sbjct: 1474 LQKYKGFKIDINC--KQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQ 1531

Query: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2534
              ++++I   + E + ++  E++  + QCLK              FE Q ++L    H +
Sbjct: 1532 GLVTEKI--QLLEGLLESWSEYENNV-QCLKTW------------FETQEKRLKQQ-HRI 1575

Query: 2535 EERFNTENLGESKQHIPE----KKNEVHKVEMFLGELLAARES------LDKLSQRGQLL 2584
             ++ + +N  +  Q + +    K+ EV K+E     L+  ++       +  L + GQ  
Sbjct: 1576 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTW 1635

Query: 2585 SEEGHGAGQEGRLCSQLL---TSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2641
            +   H  GQ   L   +L   +SH+         L   + +L     L  +L+++   V 
Sbjct: 1636 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV- 1694

Query: 2642 AIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQR 2701
               D L   +  L  ++   ++   I + LL +    V   +     E  +R +N   + 
Sbjct: 1695 ---DNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 1751

Query: 2702 VIQTQL-ETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK-------NQLEQWMESVD 2753
              Q Q  + L ++W      S    ST++    + N+ ++         +++  W++  +
Sbjct: 1752 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCN 1811

Query: 2754 QKIE------------HPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSR--- 2798
              ++            H L  Q   +        +QS       H  AL + + K +   
Sbjct: 1812 DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSL 1871

Query: 2799 -------ELYEKTED--ESFKDTAQEELKTQ----FNDIMTVAKEKMRKVE-EIVKDHLM 2844
                   E + K+ +  E++   A+E L+ Q     +D+ T+ +E+M +++ +++K   M
Sbjct: 1872 QAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSM 1930

Query: 2845 Y--LDAVHEFTDWLHSAKEELHRWSDMSGD----SSATQKKLSKIKELIDSREIGASRLS 2898
               LD ++E    L    +E+ R  +++      SS T ++ SK++  +   +    +  
Sbjct: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990

Query: 2899 RVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQ-MALSEQE 2957
                   + +Q             ++  RA  + ++  +F  Q  L +++     L EQ 
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAH-ELFQAEMFSRQQILHSIIIDGQRLLEQ- 2048

Query: 2958 FSGQVAQLEQALEQFSALLKTWAQQLTLLEGKN--TDEEIVECWHKGQEILDALQK---- 3011
              GQV   ++   + + L   W   +   + +    D +I + W + +E+ + L+K    
Sbjct: 2049 --GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQ-WQRYREMAEKLRKWLVE 2105

Query: 3012 -----------AEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQN 3060
                            +  ++  +E+    +      G     ++    L L A  G + 
Sbjct: 2106 VSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA 2165

Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTA-------KCFD-IPQNISEVSTSLQKIQEFLS 3112
              Q      ++ ++     L   K   A       KC   I  ++ ++ T  +K+ + L 
Sbjct: 2166 ALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 2225

Query: 3113 ESENGQHKLNMMLSKGE------------------LLSTLLTKEKAKGIQAKVTAAKEDW 3154
            +     H   M   + E                   LS  ++ +    +  +V   +  W
Sbjct: 2226 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQW 2285

Query: 3155 KNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQ 3214
            +     L  +   +     +   F    + + +WL++ E  V ++     D+  +   ++
Sbjct: 2286 EELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG----DILIEEMIEK 2341

Query: 3215 KLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKV 3272
              +   EEI   +    +L++  ++L +    SK+    +++ +++ ++  L +L   +V
Sbjct: 2342 LKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401

Query: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDS-RTLKLEALLSVKQ 3331
             +L   +    Q    +  L+ W+    H+      P     V DS  + +++  L+ +Q
Sbjct: 2402 KKLKETLVAVQQLDKNMSSLRTWLA---HIESELAKPI----VYDSCNSEEIQRKLNEQQ 2454

Query: 3332 EKEIQMKMIVTRGESVLQN-----------TSPEGIPTIQQQLQSVKDMWASLLSAGIRC 3380
            E +  ++   T   SVL              +     +IQQ  +++   W ++ +  +  
Sbjct: 2455 ELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 2514

Query: 3381 KSQLEGALSKWTSYQDGVRQFSGWMDSMEANL--------------NESERQHAELRDKT 3426
            + ++E     W  + D   +F  W+ S E                  E ++  A  R   
Sbjct: 2515 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 2574

Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
              L + +L+N++   Y  L        A   +  V      +  +R+  +Q+R    + +
Sbjct: 2575 ECLTQLELINKQ---YRRLARENRTDSACSLKQMV-----HEGNQRWDNLQKRVTSILRR 2626

Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQ---EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCA 3543
             +  +   +E++    +  VWL +   +   ++ +S  +  A      ++ L+  Q   +
Sbjct: 2627 LKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK-----IKQLKAFQQEIS 2681

Query: 3544 EGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLM 3603
                 +  ++   E +I    P  +   +E    + + Y   +     +++  + +L L 
Sbjct: 2682 LNHNKIEQIIAQGEQLIEKSEP-LDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLP 2740

Query: 3604 EQKFQQVDEWL---------------KTAEEKVSP-----------------RTRRQSNR 3631
            + +    D  L               ++A+  +SP                 R+ R +  
Sbjct: 2741 DDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPA 2800

Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQAL 3689
            +   I L    +W  +    RD +E   +RA    DE   + +      A  L+  + AL
Sbjct: 2801 SVDSIPL----EWDHDYDLSRD-LESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSAL 2855

Query: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
              Q+ +  K L++    ++++E+ + S +        ++K     + +  + +    +K 
Sbjct: 2856 ESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI--DSVKR 2913

Query: 3750 LEVLLKDMEK---GHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
            LE  LK+ E+   G   L S   +    +   E  +A+ L KE+                
Sbjct: 2914 LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR--------------- 2958

Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--EPKMELYEKKAQLSKYKSLQQ 3864
                +++ L   ++F+    ++  W+ + +E L   +  E   ++   + Q+ K K LQ+
Sbjct: 2959 ----MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK 3014

Query: 3865 TVLSHEPSVKSVREKGEALLEL--VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
             V   +  + S+        +    +   L+D++ Q+   +  +CS+ +E    L+  + 
Sbjct: 3015 AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 3074

Query: 3923 DHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME---EIAGFEDR 3979
              + ++ E+      +L+   R     +   S+L+    Q  HHK +M+   E+   + R
Sbjct: 3075 QCQGFH-EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ-DHHKQLMQIKHELLESQLR 3132

Query: 3980 LNNLQMKGDTLI--GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 4037
            + +LQ     L+   +  D L+AK K     H+ G +     +     R  + LE  L  
Sbjct: 3133 VASLQDMSCQLLVNAEGTDCLEAKEK----VHVIGNR--LKLLLKEVSRHIKELEKLLDV 3186

Query: 4038 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQ 4075
              S+QD      +W SA + D   S  P   R+   +Q
Sbjct: 3187 SSSQQDL----SSWSSADELDTSGSVSPTSGRSTPNRQ 3220



 Score =  107 bits (267), Expect = 5e-22
 Identities = 376/2167 (17%), Positives = 804/2167 (37%), Gaps = 284/2167 (13%)

Query: 432  QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
            Q++   +   IQ+ L++HK+  Q  ++H      ++R      +     Q E        
Sbjct: 1137 QKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV-----QKETQFHTELM 1191

Query: 492  VSSTSELHLMKMEFLELKYRLLSLLVLAESK---------LKSWIIKYGRRESVEQLLQN 542
              +++ L       +EL+Y L +   L E +         ++S I   G  E  E  L +
Sbjct: 1192 AQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251

Query: 543  YVSFIEN--SKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 600
             ++  ++  S   E     YQ+L     + +    S  E++     +N+    W + + +
Sbjct: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ-----LNQLGECWLSNTNK 1306

Query: 601  VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
            +      LE ++ +W RY +  A L  WL+ A+  L        +F+      + Q   M
Sbjct: 1307 MSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL--------EFWTQQSVTVPQELEM 1358

Query: 661  -NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 719
              D  N  +E   E+ ++   +  +L  G       +V       E+ R+  ++TD +  
Sbjct: 1359 VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN 1418

Query: 720  LSAFATEAHK----------KLSEPLEVSFMNVKLLIQDLEDIEQRVPV----------- 758
            + A   + H+           +SE +    +   ++ +D ++I+  +             
Sbjct: 1419 IPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK 1478

Query: 759  ---MDAQYKIIT-----------KTAHLITKESPQEEGKEMFATMSK----LKEQLTKVK 800
               +D   K +T            +  + +K S + +  E    M+K    L+  +T+  
Sbjct: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKI 1538

Query: 801  ECYSPLL-----YESQ-QLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 854
            +    LL     YE+  Q L    E +++       +G    +   L+       L K K
Sbjct: 1539 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 1598

Query: 855  HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQT--RLQRQIADIHVAFQSMV 912
             +E+   ++N    L LI+   + V   V   + L+   QT   L   +  + +  +S++
Sbjct: 1599 EKEVEKIEQN---GLALIQNKKEDVSSIV--MSTLRELGQTWANLDHMVGQLKILLKSVL 1653

Query: 913  KKTGDWKKHVETNSRLMKKFEESRAELEK---------VLRIAQEGLEEKGDPEELLRRH 963
             +   W  H     ++     E+R  L +          +++  + L+   D  E   R 
Sbjct: 1654 DQ---WSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS 1710

Query: 964  TEFFSQLDQRVLNAFLKAC-----DELTDILPE------------QEQQGLQEAVRKLHK 1006
             + F      + N  LK C     + LT+ L E             EQ    +A+ +L +
Sbjct: 1711 LQKFGS----ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQ 1766

Query: 1007 QWKDLQGEAPYHLLHLK------IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKE 1060
            ++KD   +    +   +      +    N+ +A  +E  T +     L+   G+   +K+
Sbjct: 1767 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD-DEVATWIQDCNDLLKGLGT---VKD 1822

Query: 1061 HRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLM 1120
               F      H L E+  Q ++         D +  +   C      L  A+      L 
Sbjct: 1823 SLFFL-----HELGEQLKQQVDASAASAIQSDQLSLSQHLC-----ALEQALCKQQTSLQ 1872

Query: 1121 EDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGET 1180
                 ++ +        +WI   E  L+G   +   +++   ++  +EE++  + K    
Sbjct: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQG--QDPSHSSDLSTIQERMEELKGQMLKFSSM 1930

Query: 1181 LSWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALVTLLSEVEKMLSNFG 1232
               L    ++   +   ++  K+   L        ++ +  F  L + L + +  L    
Sbjct: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990

Query: 1233 DCVQYKEIVKNSLEELISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKK 1289
              +++    +  L   ISG+ +    Q++A ++   E +F  QQ+L       +R+    
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAE-MFSRQQILHSIIIDGQRL---- 2045

Query: 1290 RDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNK 1349
                      +QG+    D  + +L  L +   G+ R  +++   I   +R+W+R+    
Sbjct: 2046 ---------LEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096

Query: 1350 ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLV---KEASEI 1406
            E + ++L +       +L  S L S+   L+Q      RT    VQ +  V   ++ S I
Sbjct: 2097 EKLRKWLVEVS-----YLPMSGLGSVPIPLQQA-----RTLFDEVQFKEKVFLRQQGSYI 2146

Query: 1407 PLGPQNKQL-----------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNF 1455
                  KQL           LQ +   I+E+ K     LEE  K +  +   W+      
Sbjct: 2147 LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGI 2206

Query: 1456 -ETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV 1514
             ++L    T K+K   +L      +  +  + K     + S    +  L     + + ++
Sbjct: 2207 ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYI 2266

Query: 1515 TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDK 1574
            +  + + +  ++  ++R  EEL          I   L++   F E  +++ + +++ E K
Sbjct: 2267 SADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESK 2326

Query: 1575 LAV--PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAAL 1632
            ++    I I     +  K  QE + + Q  +     +    A A           +   +
Sbjct: 2327 VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKV 2386

Query: 1633 QQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1692
              +++ +L     R   L+  L   Q+L+K +SS  TWL   E++ + P +  S +  ++
Sbjct: 2387 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 2446

Query: 1693 EGELQLIQALQNEVVSQASFYSKLLQLKESLF----SVASKDDVKMMKLHLEQLDERWRD 1748
            + +L   Q LQ ++   ++  + +L L E L     + A+  +   ++     LD RWR+
Sbjct: 2447 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN 2506

Query: 1749 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF--LSELQTTSEISIMDHQVALTRH 1806
            +  +  +R   ++      Q+F +    F  W+K     +   ++S +     +  L + 
Sbjct: 2507 ICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKF 2566

Query: 1807 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQ----LFEEASQVVER 1862
            +    +V     +L+ +     +L    R +    L+    +  Q    L +  + ++ R
Sbjct: 2567 EAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR 2626

Query: 1863 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNA 1916
             +  +    EF  +  S+   L ++   ++ TN  + +E D+      ++    +   N 
Sbjct: 2627 LKHFIGQREEFETARDSILVWLTEM--DLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 2684

Query: 1917 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADAL 1976
              +E      + ++ K++        E+    R    ++ G VER    L       D  
Sbjct: 2685 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 2744

Query: 1977 AVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQ---ALQQRLRVFNQLEDELNSHEH 2033
             +  +  + +    L  +   +   D     +P+     +L Q LR      D   S + 
Sbjct: 2745 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 2804

Query: 2034 -ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ 2092
              L W           D   + +++  ++R   + D+  +   +      G + L  ++ 
Sbjct: 2805 IPLEW---------DHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLRGAVGLSGDHS 2853

Query: 2093 NLKSAVSKV----------LENASSVIVTRTTIKDQEDLKW-AFSKHETAKNKMNYKQKD 2141
             L+S + ++          ++   ++I ++T    + D  +  + K     +      K 
Sbjct: 2854 ALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 2913

Query: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDD 2201
            L++   + +  L     +HS++     T     +D+W  +  +      R++ +L  W  
Sbjct: 2914 LEHKLKEEEESLPGFVNLHSTE-----TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 2968

Query: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2261
              S  + I  W  +   ++ +        L+  EL  + ++ ++ +  +L+EL   V+  
Sbjct: 2969 FNSDLNSIWAWLGDTEEELEQ--------LQRLELSTDIQT-IELQIKKLKELQKAVDHR 3019

Query: 2262 KE--LTKNLETPP----------DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQV 2309
            K   L+ NL +P           DLQ   + +  + +    + E  +G L+D   Q    
Sbjct: 3020 KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 3079

Query: 2310 EKFINDITTWFTKVE---ESLMNCAQNETCEAL----KKVKDIQKELQSQQSNISSTQEN 2362
             +  + +      ++     ++    N   E L    K++  I+ EL   Q  ++S Q+ 
Sbjct: 3080 HEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQD- 3138

Query: 2363 LNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQE------SLEK--HFSES 2414
                C+   +AE        T  ++  E V  + ++ +  L+E       LEK    S S
Sbjct: 3139 --MSCQLLVNAE-------GTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 3189

Query: 2415 MQEFQEW 2421
             Q+   W
Sbjct: 3190 QQDLSSW 3196



 Score = 92.4 bits (228), Expect = 2e-17
 Identities = 385/2080 (18%), Positives = 783/2080 (37%), Gaps = 278/2080 (13%)

Query: 481  QLEDMAERFHFVSSTSELHLMKMEFLELKYR-----LLSLLVLAESKLKS-WIIKYGRRE 534
            +L+DM +    +  +    L +   L+ +Y      L  LL   + K+     I    +E
Sbjct: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145

Query: 535  SVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQW 594
             ++QLL  +       ++F+  E ++ IL +T    + +    +E +   + M + +A  
Sbjct: 1146 EIQQLLDKH------KEYFQGLE-SHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 1198

Query: 595  RNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH-W 653
            +      R V   LE ++  W         L   LE  E  +      +++  R +    
Sbjct: 1199 KR--AHKRGVE--LEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 1254

Query: 654  IQQH--TAMNDAGNFLIETCDE-------MVSRDLKQQLLLLNGRWRELFMEVKQYAQAD 704
            + QH  +++N+    L +  D+       +   DL+ QL  L   W  L    K   +  
Sbjct: 1255 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECW--LSNTNKMSKELH 1312

Query: 705  EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYK 764
             ++ + K +T    + SA      +   + LE        + Q+LE +   +       K
Sbjct: 1313 RLETILKHWTR-YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK 1371

Query: 765  IITKTAHLITKESPQEEGKEMF----ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEEL 820
             +   + L  K S    G ++        + L+ +L+++   ++ LL     +   L +L
Sbjct: 1372 EVDAQSSL--KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 1429

Query: 821  EKQMTSFYDSLGKINEIITVLEREAQ-------SSALFKQKHQEL-----LACQENCKKT 868
            +        ++ ++   I+++E   Q       +S  +K  H+ L          NCK+ 
Sbjct: 1430 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQL 1489

Query: 869  LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGD----------- 917
               ++  +QSV +  +     K  D+T    Q+  ++ ++Q +     +           
Sbjct: 1490 T--VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES 1547

Query: 918  WKKHVETNSRLMKKFEESRAELEKVLRIA-----QEGLEEKGDPEELLRRHTEFFSQLDQ 972
            W ++      L   FE     L++  RI      Q  L++  D E+L++   +   +++Q
Sbjct: 1548 WSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607

Query: 973  RVLNAFLKACDELTDILPE------QEQQGLQEAVRKLHKQWKDLQGEAPYH-------- 1018
              L       ++++ I+        Q    L   V +L    K +  +   H        
Sbjct: 1608 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 1667

Query: 1019 --LLHLKIDVEKNRFLA-SVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCE 1075
              L+  +  + + R L  S+E  + ++D    L  Q+  EK  +  + F S         
Sbjct: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNL--QDDLEKQERSLQKFGSITN------ 1719

Query: 1076 KRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK---DYTSR 1132
               QL++E         PV +T      TLKE+    ++   ++ E     K       R
Sbjct: 1720 ---QLLKEC------HPPVTETLTN---TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 1767

Query: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL---KSRLK 1189
            + ++S   ++   Q +    E +  A + ++  A +E+   +    + L  L   K  L 
Sbjct: 1768 YKDYSKQCASTVQQQEDRTNELLKAATNKDI--ADDEVATWIQDCNDLLKGLGTVKDSLF 1825

Query: 1190 VLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE-EL 1248
             L E+  + + Q      + + S   +L   L  +E+ L     C Q   +    L+ E 
Sbjct: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-----CKQQTSLQAGVLDYET 1880

Query: 1249 ISGSKEVQE----QAEKILDTENLFEAQQL--LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
             + S E  E    +AE+IL  ++   +  L  +    ++ K    K   +   + +  + 
Sbjct: 1881 FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940

Query: 1303 EGGLP--DRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTG 1360
               LP  D+  + ++ L      +      +  ++Q  L + + F    ET + +L QT 
Sbjct: 1941 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 2000

Query: 1361 SSHERFLSFSSLESLSS----ELEQTKEFSKRT--ESIAVQAENLVKEASEIPLGPQNKQ 1414
                  +S +    L      EL Q + FS++    SI +  + L+++         N +
Sbjct: 2001 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 2060

Query: 1415 L--LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNAL 1472
            L  L  Q + +  + ++    ++  I+       +W  +    E L  W+ E    ++ L
Sbjct: 2061 LTLLSNQWQGVIRRAQQRRGIIDSQIR-------QWQRYREMAEKLRKWLVE----VSYL 2109

Query: 1473 ETSS-SAMDMQISQIKVTIQEIESK-------LSSIVGLEEEAQSFAQFVTTGESARIKA 1524
              S   ++ + + Q +    E++ K         S +   E  +       +G  A ++A
Sbjct: 2110 PMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQA 2169

Query: 1525 KLTQIR--------RYGEELREHAQCL---EGTILGHLSQQQKFEENLRKIQQSVSEFED 1573
            +L +I+        R  E+ ++ A  L   E    G     +K     +K+ QS+ +  +
Sbjct: 2170 ELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE 2229

Query: 1574 KLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAF-SASARKVVNRDSCVQEAAAL 1632
            +L      C    E    +    D    L  L   ++A+ SA    ++N     +    L
Sbjct: 2230 ELHAEQMRCK---ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN-----ERVELL 2281

Query: 1633 QQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1692
            Q+Q+E++  +   R+  +   L  W    ++      WL + E+K S      + D +  
Sbjct: 2282 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ-----NGDILIE 2336

Query: 1693 EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQI 1752
            E   +L +  Q E+        +L Q+ E L   + +     ++  L ++++RW+ L  +
Sbjct: 2337 EMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396

Query: 1753 INKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAE 1812
            I  R+  L+  +   QQ D+ + S   W+    SEL              +     ++ E
Sbjct: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-----------PIVYDSCNSEE 2445

Query: 1813 VESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAE 1872
            ++ K  E Q LQ  + K  S G A  L+L +    DC     +A    +  Q A  +L  
Sbjct: 2446 IQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAE--CDSIQQATRNLDR 2502

Query: 1873 FLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSK 1932
              ++  ++S    + R  +E T  + +   D   +   D L++++   +   S   I + 
Sbjct: 2503 RWRNICAMS---MERRLKIEETWRLWQKFLDDYSR-FEDWLKSSERTAAFPSSSGVIYTV 2558

Query: 1933 AQYHLKIGSSEQRT--SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD---QK 1987
            A+  LK   + QR    C    + +  +  R+      +++  D+   LK+   +   + 
Sbjct: 2559 AKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLKQMVHEGNQRW 2613

Query: 1988 EELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDELNSHEH-ELCWLKDKAKQI 2045
            + L K +  I  R       +E    A    L    +++ +L + EH   C ++ K KQ+
Sbjct: 2614 DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL 2673

Query: 2046 AQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKV---L 2102
                 AF  E+    N++E      ++LI +++     +I+   E   L+    +V   +
Sbjct: 2674 K----AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--EELDELRRYCQEVFGRV 2727

Query: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
            E     ++      D+ DL              + ++ +L++  +     LS+L     S
Sbjct: 2728 ERYHKKLIRLPLPDDEHDL--------------SDRELELEDSAA-----LSDLHWHDRS 2768

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSI------WDDVLSTRDEIEGWSNNC 2216
              SL+     S +   L +++ L           S+      WD       ++E   +  
Sbjct: 2769 ADSLLSPQPSSNLS--LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRA 2826

Query: 2217 VP-QMAENISNLDNHLRAEELL----KEFESEVKNKALRLEELHSKVNDLKELTKN-LET 2270
            +P +  E   + D +LR    L       ES+++     L++   ++   + + ++   T
Sbjct: 2827 LPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 2886

Query: 2271 PPDLQ-------------FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDIT 2317
             P+L                  D +++LEH  +  E +     +  +  TQ    I+   
Sbjct: 2887 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWE 2946

Query: 2318 TWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELES 2377
                +     +   QN     L+K +    +L S  + +  T+E L  L R   S ++++
Sbjct: 2947 LLQAQALSKELRMKQN-----LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001

Query: 2378 LGRAMTGLIKKHEAVS---------QLCSK--TQASLQES 2406
            +   +  L +  +AV           LCS   TQA  +ES
Sbjct: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score = 2051 bits (5315), Expect = 0.0
 Identities = 1747/6330 (27%), Positives = 2987/6330 (47%), Gaps = 542/6330 (8%)

Query: 2749 MESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--LYEKTED 2806
            +  V   ++  L+ +   KE    +   Q +L + E        LI+K +E  +   T+ 
Sbjct: 837  LTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGE----LISKHKEALIISNTKS 892

Query: 2807 ESFKDTAQEELKTQFN-DIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2865
             +    A EELK     DI    +EK R V    K   ++    HE + ++   K ++ +
Sbjct: 893  LAKYLKAVEELKNNVTEDIKMSLEEKSRDV--CAKWESLH----HELSLYVQQLKIDIEK 946

Query: 2866 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC--ELMHTEM 2923
               +S +    +K+++K K+LI        R  R + L  E +   +  GC  +L H  M
Sbjct: 947  -GKLSDNILKLEKQINKEKKLI--------RRGRTKGLIKEHEACFSEEGCLYQLNH-HM 996

Query: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQL 2983
            + LR   ++      ++Q  ++ L+       +      +++   L+  +         +
Sbjct: 997  EVLRELCEELPSQ--KSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTI 1054

Query: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE-DLKSQLNELCRFSRDLSTYSGKVSG 3042
            T  E +  D      + K        +  EP  +  L S L  L   S     YS  ++ 
Sbjct: 1055 TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINS 1114

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
            L++ Y+          QN +  +   F     D     + AK+T  +   + +N ++   
Sbjct: 1115 LLERYDTYRDILEHHLQNNKFRITSDFSSE-EDRSSSCLQAKLTDLQ---VIKNETDARW 1170

Query: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
               +I     E+     K   ++ + + L     KE+ + +Q  +    E  +     + 
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTL-----KERERELQMTLNTRMESLETALRLVL 1225

Query: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE-----QQKLQ 3217
              E A  +L +   D  +    IQ +       +++    + D  AK+ E     ++   
Sbjct: 1226 PVEKA--SLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGN 1283

Query: 3218 SVLEEIHCYEPQLNR---LKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN-------- 3266
             VL+E+H ++    +   LK K Q  +EG        HRV +      AL +        
Sbjct: 1284 FVLKELHPFDLHAMQNIILKYKTQ--FEGM------NHRVQRSEDTLKALEDFLASLRTA 1335

Query: 3267 -LTKEKVSRL---DRIVAEHNQFSLGIKELQ-DWMTDAIHMLDSYCH------------- 3308
             L+ E V+ L   D  VA+ N  ++  KE +   M D    LD                 
Sbjct: 1336 KLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGD 1395

Query: 3309 PTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV-- 3366
             TS +++LD+ ++KL        ++E   +  +        N   + I  +Q Q+  +  
Sbjct: 1396 DTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGL 1455

Query: 3367 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG----WMDSMEANLNESERQHAEL 3422
            KD     +    +   +L+  L ++   +  +++ +     + D  E  +N+  +    L
Sbjct: 1456 KDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVL 1515

Query: 3423 RDKTTML--------GKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYR 3474
             + T  L        G+   L ++  ++ S+L T+  K   +     + +  ++L++R  
Sbjct: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIA 1575

Query: 3475 AIQ------ERAKEAVTKSEKLVRLHQEYQRDLKAFEV-------------WLGQEQEKL 3515
             I+          E V K  ++ +  Q Y   +K FE              WL   ++  
Sbjct: 1576 EIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTE 1635

Query: 3516 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3575
            D Y  L G A      L +L+ +     E +AL    LH   +         EDR  E L
Sbjct: 1636 DYYENL-GRALALWDKLFNLKNVIDEWTE-KALQKMELHQLTE---------EDR--ERL 1682

Query: 3576 RQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE 3635
            +++ Q ++ + SE    F+  V +++ + Q   ++   L+  E  +  +        T E
Sbjct: 1683 KEELQVHEQKTSE----FSRRVAEIQFLLQS-SEIPLELQVMESSILNKMEHVQKCLTGE 1737

Query: 3636 IQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLE 3695
               H +     E+   R+++++  A+ Q  + ES + +     + ++ ++ + +  Q+L+
Sbjct: 1738 SNCHALSGSTAEL---REDLDQ--AKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ 1792

Query: 3696 ----------QIKFLEEEIQSLEESESSLS-----------------------SYSDWYG 3722
                      QI  L  E+  L++   S+S                       +++DW+ 
Sbjct: 1793 QKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFS 1852

Query: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
            +   N K      +   +V   +KL+ L   L  +E  +S +K      +   K+L +  
Sbjct: 1853 NIKVNLKECFESSETKKSVE--QKLQKLSDFLT-LEGRNSKIKQVDSVLKHVKKHLPKAH 1909

Query: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
             + L   +     +L+++ S  +     LE  L       D  + L +W+   +E     
Sbjct: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969

Query: 3843 EEP--KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
            EEP  K EL+ +   L++ +   ++V     S+K      E   E++ + T    +D+ Q
Sbjct: 1970 EEPGEKTELFCQA--LARKREQFESVAQLNNSLKEYGFTEEE--EIIMEATCL--MDRYQ 2023

Query: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
            +  + L  I +E     +    + + +N    +V  W+ ++   L+  +  E        
Sbjct: 2024 TLLRQLSEIEEED----KLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEG------- 2072

Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC---ADHLQAKLKQNVHAHLQGTKDSY 4017
                  K  +EE       +  L+ +GD  I      A+  +A L Q     +    D+ 
Sbjct: 2073 ------KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNT 2126

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVK 4077
              + ST     + L  E +K++  ++ L+     L   Q +   + Q  L   +A  Q+K
Sbjct: 2127 LHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ-EAGFALQHGLQEKKA--QLK 2183

Query: 4078 HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKH 4137
             ++   ++A+    LL  +    N  ++ T       E                W EIKH
Sbjct: 2184 IYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEP---------------WLEIKH 2228

Query: 4138 LKSELWIYLQDADQQLQNMKRRHSELEL----------NIAQNMVS---------QVKDF 4178
            L   L   LQD+ Q L    R H   ++          N ++  VS          V++ 
Sbjct: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK 2288

Query: 4179 VKKLQS-------KQASVNTIIEKVNKLTKKEESPEHK----EINHLNDQWLDL------ 4221
            ++KLQ        +  ++  I+     + +   S   K    +I  L  +  DL      
Sbjct: 2289 LQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLAS 2348

Query: 4222 CRQSNNLCLQREEDLQRT-----------RDYHDCMNVVE-----VFLEKFTTEWDNLAR 4265
             +Q    CL      +R+           R+     +V E       +EK   +W+    
Sbjct: 2349 AKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEI--- 2405

Query: 4266 SDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW 4325
               + +AV +   K+L+L  QE     ED +   +   + L LD   L  EQ   +E+ +
Sbjct: 2406 --NKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTM-LRNEQLEEIEKLY 2462

Query: 4326 FQLEDLIKRKIQVSVTNLEELNVVQSRFQEL--MEWAEEQQPNIAEALKQSPPPDMAQNL 4383
             QLE   K+     +   E LN  ++    L  + ++ +   N+ +AL        +Q  
Sbjct: 2463 TQLE--AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520

Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADL--GLNERQVIQKALSDAQSHVNCLSDLV 4441
            ++        L A +  +K+L+ D + +       +     I+K ++  +   + L +L 
Sbjct: 2521 VLRDFQ--EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLK 2578

Query: 4442 GQRRKYLNKALSEKTQFLMAVFQATS----QIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
             +     N       + L +  +       Q++Q  +K   ++ +    D+ +  +   +
Sbjct: 2579 IKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEY--DEFTTLMNKVQ 2636

Query: 4498 SAQASLKTYQNEV--------------------TGLWA--QGRELMKEVTEQEKSEVLGK 4535
              + SL+  Q  +                    T L A   G  ++K   E +   + G+
Sbjct: 2637 DTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGE 2696

Query: 4536 LQELQSVYDSV--LQKCSHRLQELE---KNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4590
             +E +++ D +  L+K    L+ L    +N + +   +    +   W K       P I 
Sbjct: 2697 -KEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIP 2755

Query: 4591 LMNES--SELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNAL 4648
            L+ +   S++      +  IL +    E+L   ++      +PSL   + S L+  L  L
Sbjct: 2756 LLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDK----VPSLTTYEGSDLNNTLEDL 2811

Query: 4649 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFL-RMSKVPTDLAVE 4707
              Q+ ++V  +  +  +++  +  R  + ++I      + E E   + R+    T+  ++
Sbjct: 2812 RNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELK 2871

Query: 4708 EALSLQDGCRAILDEV-AGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT 4766
                  +  +  L E+ +G+   + EL    E      + +  D++ +L    +R++R  
Sbjct: 2872 HHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQR-- 2929

Query: 4767 EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE-ETLPAEEKLKMYHSLAGSL 4825
                  +++T +  +   K C+Q   +  +++EE   +   E L  +E  K       +L
Sbjct: 2930 -----FIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984

Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
            +D    +K   + +  L    D +       Q+   Q ++      + E + + ++   +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE 3044

Query: 4886 SIDFQTEMS--RSLDWLRR------VKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4937
               +Q  +S  R++D   +      +KA  S P    LN Q + + I K +   +E+   
Sbjct: 3045 HGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKK 3104

Query: 4938 LRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELS--ELDG-DIQEALRTRQAT 4987
            L          KEK     +L + +       L++ + ELS  ELD  + Q+ L T    
Sbjct: 3105 LNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV 3164

Query: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
            L +I SQ Q+   +            E+  +     + E+ +E + + M           
Sbjct: 3165 LNQIKSQLQQPLLI----------NLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEK 3214

Query: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKV-ASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5106
              EE  S  + ++  ++    EDL+ ++  S++LR+  ++       D  +  T     Y
Sbjct: 3215 QREENSSEASDVETKLREF--EDLQMQLNTSIDLRTNVLN-------DAYENLTR----Y 3261

Query: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA 5166
            ++A    +E +   E  +  + +   +     E  L + + L S V         +++  
Sbjct: 3262 KEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV-------AHIQDLT 3314

Query: 5167 SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5226
             +L    +  +K  L  ++  +  + + ++   + QE   E  ++ +  +    +     
Sbjct: 3315 EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTN 3374

Query: 5227 IDQLQDKLPGS-SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAP 5285
            + +++  L  S S+   S  E L  LE     V  L   +  L  LRQ  L +L+     
Sbjct: 3375 LSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ-ILRLLR--LRC 3431

Query: 5286 TPGEEPPLMQEITAMQDRCLNMQE----------KVKTNGKLVKQELKDREMVETQINSV 5335
            T  +   L++ ++A+ ++ L++ E          ++K   K V +E++   ++   +   
Sbjct: 3432 TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEE 3491

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTIL 5392
               + +TKE          A  EEL  LL     + +N+EK   +     ++   +  + 
Sbjct: 3492 LPEISKTKEA---------ATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542

Query: 5393 PSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK 5451
             S  +++      ++  ++++    +++V+++K   Q   ++     K++  +    +  
Sbjct: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602

Query: 5452 TDNVVQ-AKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5510
            T +    A  D     E+ +   S L +     +  +E          K   K +E++  
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIME----------KLRIKYSEMYTI 3652

Query: 5511 TIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 5568
               + E+++ +  +A   ++E   NE+L+    +  + K+        N    L+++   
Sbjct: 3653 VPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712

Query: 5569 HQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------RETEELRQM 5619
             +   E  K++  EL+    KL  L S      E+   Q  E         ++ +++ Q 
Sbjct: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772

Query: 5620 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 5679
             + R   L  A   M+++   LK  +A +E     L +P          LSH  H  +  
Sbjct: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH--HASTVQ 3828

Query: 5680 ESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 5736
             +L+   Q   L  S     ED   +  +  L  +   L  + + LQ   ++    +Q  
Sbjct: 3829 MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRM 3888

Query: 5737 VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIA 5796
                   E E+K +++ +      +  K +   + +E    +   E + + I+  ++ IA
Sbjct: 3889 ADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENIRPMKKTIA 3945

Query: 5797 SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5856
             + S    L +       L        L +  + L+            V+  T      +
Sbjct: 3946 EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEI 4005

Query: 5857 --LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAA 5912
              L  +      + +   +S   A + P      +    Q ++  Q        L+    
Sbjct: 4006 ENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVL 4065

Query: 5913 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 5972
             +H      QE  E    P+ T++ G +       +   SE++     ++      ++ +
Sbjct: 4066 NLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEV 4119

Query: 5973 QSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAE 6026
            +  S K +  + K   SP+   S    +  M E +A      ++Q+   +I+   +S+A+
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179

Query: 6027 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--Q 6083
             L  +S   +   + +L+   T   E  +T  ++A        +  L  ++E+ R E  +
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236

Query: 6084 ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL 6143
             L   + +  EL+ WL      ++           +E QL+ CQ ML EIE KV  L E 
Sbjct: 4237 VLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLET 4296

Query: 6144 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6203
                ++  L     T+ EAE L+ KL+ +K +L ++Q  L +K    Q     K+ S+ +
Sbjct: 4297 C---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPE 4353

Query: 6204 LTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
                  P     L    T   Q  RQ   QQQ+ LE +  EQK  ++ +    +++  Q+
Sbjct: 4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQY 4413

Query: 6263 SAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQE 6320
               +  T+ ++       S E  +     S + Q   KW+ LH E S+K KL    L + 
Sbjct: 4414 CQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEP 4473

Query: 6321 QEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHL 6379
            Q     S    +L  V +Y    PT ++    T+ L+ L Q    + +Q    +   I+L
Sbjct: 4474 Q----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINL 4529

Query: 6380 EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL 6439
            ++KL++     S  L  VEE L +   L  E+      + E LA ++K++   +   K  
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588

Query: 6440 FSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 6499
              +A    G+N +++ +    L   L    +    R   +K  L    ++QN++K L+  
Sbjct: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648

Query: 6500 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 6559
            L  +K  + Q L  +  Q VAEQ++        L+  ++ + +L+  G++L +    +QE
Sbjct: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708

Query: 6560 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 6619
            + KL+D+ D +  ++ +R + L+     +SQ +  LQ + +L++ G+EK+A        S
Sbjct: 4709 VYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKS 4768

Query: 6620 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6679
            K  +Q  ++ HK +FQ L + M+L +    KI+   +Q    F  E + +   + +++ +
Sbjct: 4769 KVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQ 4828

Query: 6680 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6739
             G++L+ +L+ W   DE+   L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++
Sbjct: 4829 CGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888

Query: 6740 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR 6799
                 +LYQ L++GK+L+ S+SC +LE Q+ +L E WLS   K+  ELHRL+ +LKH   
Sbjct: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS 4948

Query: 6800 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 6859
            Y  +S  L  WL+S++  L +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V
Sbjct: 4949 YNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAV 5008

Query: 6860 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 6919
            +S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E+
Sbjct: 5009 ISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068

Query: 6920 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6979
            +SW++ +E+    DED++ +      +   LQK+K F+++++ KQ  VDFVNQS+LQ+S+
Sbjct: 5069 ISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLST 5127

Query: 6980 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 7039
             DVESKR ++T+FAE LG MN+ W  + G++  KIQ LE LLES +E EN +Q L  W E
Sbjct: 5128 CDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLE 5187

Query: 7040 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 7099
             QE+RLK   +     SVQ  L DCQD+E+ +  K K +++++Q+ L L ++    +   
Sbjct: 5188 AQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLED 5246

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 7159
              S + EL Q  +++   V QLK  ++SVL +W  +   +D++N   +   Y +   + +
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306

Query: 7160 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 7219
              SLE ++ QV+NLQ+LQD+ E  E S +K   +  +L   C P V E +    +  + R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKR 5365

Query: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 7279
            W  + + IA+QLQ +++LLQLW+ Y +   + A+ ++QQE +  +L   + + +   + +
Sbjct: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425

Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
               +QD  +L   +   K++      + ++L Q  ++S    +     SL Q    LE+ 
Sbjct: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKM 5484

Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7399
            L  +    +  +  ++ F   LE+L+  I+  EE L   D  H  +    +E  +     
Sbjct: 5485 LLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNH 5537

Query: 7400 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7459
            +L  ++ +PD++ LNE+  +LPL+D  +K +QN+NR W   ++   ER S+LQ   L ++
Sbjct: 5538 VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NE 5596

Query: 7460 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 7519
             FL  CE W++ L + E+ L V+++ +   LLEQQ+ +++ +AE+   Q I  S +    
Sbjct: 5597 KFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSL 5656

Query: 7520 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 7579
            +LL+  ++++R EF  + + L+++WQ  ++  +QR+G +D  +RQWQ +    E L ++L
Sbjct: 5657 QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFL 5716

Query: 7580 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7639
             + S+L  +  G     L Q R+L  E++ KE  F R++ +  LT+EAG++LLL+ D   
Sbjct: 5717 TDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKT 5776

Query: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699
            + ++   ++++Q+ WK    +L E  K+    ++ W++CEK I +   +L+  K +    
Sbjct: 5777 KESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP 5836

Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
            LP+ HE+LH E+   KELE ++ SWT +L +L  +K  L+ ++  +D+ +L E++E L R
Sbjct: 5837 LPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHR 5896

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            QWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q  DI IEEMIEKL+
Sbjct: 5897 QWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ 5956

Query: 7820 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 7879
            KD  EEI +  ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKK
Sbjct: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKK 6016

Query: 7880 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 7939
            LKET   +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+H
Sbjct: 6017 LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQH 6076

Query: 7940 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 7999
            S GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWR
Sbjct: 6077 SAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWR 6136

Query: 8000 LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 8059
            LWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELI
Sbjct: 6137 LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELI 6196

Query: 8060 NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 8119
            NKQYRRLARENRTD+A  LKQMVHEGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+S
Sbjct: 6197 NKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRES 6256

Query: 8120 ILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
            ILVWLTEMDLQLTN+EHFSE D   K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEP
Sbjct: 6257 ILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEP 6316

Query: 8180 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDL 8238
            LDA +IE+EL+EL RYCQEVFGRV R+H++L    P  +DE + S+ E ++ED   +   
Sbjct: 6317 LDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTD 6376

Query: 8239 HWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL------S 8292
             W  R      S +PSS  SL        ERSG +TP SVDSIPLEWDH  D+       
Sbjct: 6377 SWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGSSSHE 6432

Query: 8293 RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLGKALDDSRFQI 8349
             D E     AL   D E  ++ + YL+     +  S   S  +     +  +        
Sbjct: 6433 EDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVPDSPSCPEHHY 6490

Query: 8350 QQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
            +Q E   R+  P  P   T YK   G + L        +  + L    ++E+  L G   
Sbjct: 6491 KQMEG-DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE 6549

Query: 8407 LHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 8466
                  Q +G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L
Sbjct: 6550 ------QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEML 6600

Query: 8467 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 8526
            +  +  +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q
Sbjct: 6601 KMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660

Query: 8527 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 8586
            ++  W+     ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D  
Sbjct: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720

Query: 8587 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 8646
             L +  ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L 
Sbjct: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780

Query: 8647 KEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLS 8706
            ++VS      + L+ +  +Q   S   S DE+D SG   P +                 S
Sbjct: 6781 EQVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT-----------------S 6816

Query: 8707 QPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVP 8766
             P P       R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P
Sbjct: 6817 VPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6876

Query: 8767 MSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
             SEEDYSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 6877 SSEEDYSCTQANNFARSFYPMLRYTNGPPP 6906



 Score =  608 bits (1569), Expect = e-173
 Identities = 1245/6222 (20%), Positives = 2449/6222 (39%), Gaps = 953/6222 (15%)

Query: 21   LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
            LQ EQE  QK+ FT WINS LA+   P V+ DLF D+K G  LL LLEVLSGQ+LP ++G
Sbjct: 25   LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84

Query: 81   RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
                +     NI  AL FL  R IKL+NI+ TDI DG PSI+LGL+WTIIL+F IE+L  
Sbjct: 85   SNTFQCRI--NIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142

Query: 141  NLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYTAGKQTGI 198
             L        S   V  + SS   SPP+K+  KV  + Q +A+KALL W Q        +
Sbjct: 143  TL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESV 201

Query: 199  EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
             V DF  SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL IPRLL+P
Sbjct: 202  NVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEP 261

Query: 259  EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
            EDVDV  PDEKSIMTYVAQFL++  D      + Q   +   G+ +              
Sbjct: 262  EDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK----------- 310

Query: 319  IFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKL 378
              ++++  ++  E D             KY S   F   +  ++K    ++       +L
Sbjct: 311  --EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDEL 359

Query: 379  SLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEET 438
              D   ++++WD +  ++  W I+L+ +LP PL    AWL   E  + E+++  Q H + 
Sbjct: 360  DKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQA 419

Query: 439  ANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFHFVSSTSE 497
               IQ K+   K L+   + H       +  +  N +P VPP++LE+M  R + +    +
Sbjct: 420  VTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRINNI--LEK 476

Query: 498  LHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYE 557
              ++ +EF   K  +L L+   +SKL  W IKYG RESVE LL+++  FIE  +F  + +
Sbjct: 477  KFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLD 536

Query: 558  VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDR 617
             ++Q   +  E+Y    G  +        +      +R     + +V+S L++V++ W  
Sbjct: 537  TSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQKVLACWAT 590

Query: 618  YGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSR 677
            Y   +  L+A  E+ +K     E  K+  F  L  W  +H  +N+AGNFL+E  +++V  
Sbjct: 591  YVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGS 645

Query: 678  DLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEV 737
             + ++L  LN RWR+L  + +                                    LE 
Sbjct: 646  SISKELRRLNKRWRKLVSKTQ------------------------------------LE- 668

Query: 738  SFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFATMSKLKEQ 795
              MN+ L+I+     +Q  P  D    I++K      + S     E  E +    K  E+
Sbjct: 669  --MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEK 721

Query: 796  LTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFK 852
              K  E ++  L    + ++L+  +E  E +  S  D     +++ T +E   +      
Sbjct: 722  HEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESLKHLIAKG 777

Query: 853  QKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMV 912
                EL+A  E+      +++   Q++    +  +VL    Q ++Q     + +   ++V
Sbjct: 778  SMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI---NVV 828

Query: 913  KKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQL 970
            K     K    V  +  +  K EES+ ELE  +  AQ+ L ++  P EL+ +H E     
Sbjct: 829  KLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIIS 888

Query: 971  DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1030
            + + L  +LKA +EL + + E  +  L+E  R +  +W+ L  E   ++  LKID+EK +
Sbjct: 889  NTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGK 948

Query: 1031 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPV 1090
               ++ +   ++++E KL+ +  ++ +IKEH   FS++G  +     ++++ ELC +LP 
Sbjct: 949  LSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS 1008

Query: 1091 RDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGI 1150
            +   ++        LK+    I+   +   E     +      S+    I+T+E +    
Sbjct: 1009 QKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP 1064

Query: 1151 KGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELA 1208
              EA    + N    ++A+E           T+ +  S   VL  +  E+  +K  D  A
Sbjct: 1065 HSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIMEK--DYSA 1110

Query: 1209 KLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVKNSLE--- 1246
             ++S  +   T    +E  L N                  C+Q K    +++KN  +   
Sbjct: 1111 SINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARW 1170

Query: 1247 ---ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQLLLHHQQK 1281
               E+IS                      KE + + +  L+T  E+L  A +L+L  ++ 
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKA 1230

Query: 1282 TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRK 1341
            +  +      + +   Q         DR ++ LR ++ ++        R E      L++
Sbjct: 1231 SLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288

Query: 1342 WERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
               F+ +  +  +++Y  Q  G +H    S  +L++L   L   +      E +   + +
Sbjct: 1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348

Query: 1399 LVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEEDIKTMEMV 1444
              + A E  L  +NK+    L++ +AK + + +K L          +DT  E++     +
Sbjct: 1349 DTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSI 1408

Query: 1445 KTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV---TIQEI 1493
            K    H +G   E      TE+ K L       N L  +   +  QIS+I +   T+  +
Sbjct: 1409 KLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAV 1463

Query: 1494 ESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREH 1539
            + +  S++               L+E A S   F    E    +     +  +       
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523

Query: 1540 AQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATETYKVLQE 1594
             +CLE  G +L  L Q Q F+  L  +   ++SV   +        +     E   V +E
Sbjct: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEE 1583

Query: 1595 HMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652
              +  + ++ ++       F  +  K        +EA  +  ++ DI  + ++    L  
Sbjct: 1584 FNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGR 1643

Query: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
             LA W +L    +    W E+   K    ++    DR +++ ELQ+ +   +E   + + 
Sbjct: 1644 ALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSEFSRRVAE 1702

Query: 1713 YSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLPQIINKRI 1757
               LLQ  E    +   +   + K+ H+++                E   DL Q    +I
Sbjct: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQ-AKTQI 1761

Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--------LTRHKDH 1809
               +S++      D L + F+   ++    LQ    + ++++Q+         L +  + 
Sbjct: 1762 GMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYES 1820

Query: 1810 AAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQVVERRQLA 1866
             +++ + K  +  LQ H +KL         D    ++   ++CF+  E    V ++ Q  
Sbjct: 1821 VSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878

Query: 1867 LSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES--DLIEKDL 1909
               L                + ++ H   + +   +   V     + K ES      K+L
Sbjct: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKEL 1938

Query: 1910 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1969
             D+LQ    L+    +L   L+  +   K G  E           L  + E+ +++    
Sbjct: 1939 EDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQFESVAQLN 1997

Query: 1970 QS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPTR------ 2011
             S       E + + +      D+ + LL+ + +IEE      T+ +   +         
Sbjct: 1998 NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI 2057

Query: 2012 QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAPEVDREIN 2061
            + +++ L V N  E ++   E      E+  LK +        + Q + + AP V + + 
Sbjct: 2058 KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLT 2117

Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL 2121
             +   WD+T  L              +   + L     K L++   + +    +K +++ 
Sbjct: 2118 DISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEA 2167

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV--DKWL 2179
             +A  +H   + K   + K    F  K + L S LK++ S    L++     +   + WL
Sbjct: 2168 GFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWL 2224

Query: 2180 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKE 2239
            ++ + L E++                           + Q+ +++ NLD H+R       
Sbjct: 2225 EI-KHLHESL---------------------------LQQLQDSVQNLDGHVR------- 2249

Query: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL 2299
               E  +  + + +L++ +++  +   +    P  Q    + +QKL+  +    +  GTL
Sbjct: 2250 ---EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTL 2306

Query: 2300 KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISST 2359
            K   A +  V++  + +     K +   + C Q          KD++  L S +  +   
Sbjct: 2307 KKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASAKQEMECC 2356

Query: 2360 QENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHFSESMQEF 2418
               LNS+ +   S E +      T   ++ +A S +   TQ S   E LE+ +  +    
Sbjct: 2357 ---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSA 2410

Query: 2419 QEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAVTQEGQTL 2473
             E  +  + +  A+ES   T D    E K+++LQN    LD++   +       +E + L
Sbjct: 2411 VEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ-----LEEIEKL 2461

Query: 2474 YAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLW 2530
            Y  L  +   I    Q +     E     L       Q L +    L + +         
Sbjct: 2462 YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521

Query: 2531 IHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESLDKLSQRG 2581
            + + +E       + + L   K+ +     +    + K++ F+  +   ++SL  L  + 
Sbjct: 2522 LRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKW 2581

Query: 2582 QLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQ--- 2634
            + LS   H    + +L      QL    + + +  ++K     V   E   L   +Q   
Sbjct: 2582 ENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639

Query: 2635 -SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNMAIGKGEQ 2690
             S+    + +Q RL   E   G++  +       +      ++KG+ E+++    G+ E 
Sbjct: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKE- 2698

Query: 2691 ALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSSVHAQSTL 2728
              + + ++G   ++ Q ETL+                       +WA  +   ++    L
Sbjct: 2699 --KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPL 2756

Query: 2729 --ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2779
              + ++SQ        +  + R+  +E   E V  K+     P     E   L + L+ +
Sbjct: 2757 LPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDLNNTLEDL 2811

Query: 2780 LSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKEKMRKVEE 2837
             ++   +   + +   +S++L  K E+ S  F    + +L  Q ++ + + + +    E 
Sbjct: 2812 RNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEA 2868

Query: 2838 IVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASR 2896
             +K H + L+A  +    + S     L   +++  + +  ++    +++ + + +I  +R
Sbjct: 2869 ELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKNLKIRTNR 2926

Query: 2897 LSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
            + R +++   EV+       C   H +  AL+ +     DS+ + +  L   V++    E
Sbjct: 2927 IQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEVNKGVKEE 2980

Query: 2956 QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQ-KAEP 3014
                  +  L+  L      +      L +L+ K   + I   W   Q  LD LQ +   
Sbjct: 2981 ------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQLQTQVFE 3026

Query: 3015 RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFR 3074
            + ++L+ ++ +L  F  +     GK   L+ +   + LQ  K    +  +         R
Sbjct: 3027 KEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAPDSSPESR 3080

Query: 3075 DFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNMMLSKGEL 3130
                 +++ +I  AKC   +I + ++E  T     K +E L    N +    +      +
Sbjct: 3081 RLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNM 3140

Query: 3131 LSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVSAEPIQD- 3187
            +  L  KE   K  Q K+  +        S L Q    L NL+I+ +++ + + E  Q+ 
Sbjct: 3141 VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDNCEAFQEQ 3198

Query: 3188 -W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI---------HCYEPQ 3229
             W        ++  EK   E+S+   D+  K RE + LQ  L              YE  
Sbjct: 3199 VWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYE-N 3257

Query: 3230 LNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLALSNLTKEK 3271
            L R KE   +  E   + ++                     +  +L S    + +LT EK
Sbjct: 3258 LTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLT-EK 3316

Query: 3272 VS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPTSDKSVLD 3317
            +               L  +V++++      K  +   T+A   L++Y C+   ++ +  
Sbjct: 3317 LGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRKMEEDIYT 3373

Query: 3318 S------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV----------LQNTS 3352
            +             +L L   EAL  ++Q K +   +I T+ E +          L+ T 
Sbjct: 3374 NLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433

Query: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
             +GI  + + + ++ + W SLL A    +   E    +W    + + + +  +D+++  L
Sbjct: 3434 NDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEEL 3492

Query: 3413 NE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVKGAGMTE- 3458
             E        +  + +EL D     G    K +LL   +L     ++ + E  GA  T  
Sbjct: 3493 PEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVP 3552

Query: 3459 --HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQ 3510
                +T ++      LQ +Q+    +Q   +E  + +++++ L   +Q+   +F+    Q
Sbjct: 3553 AFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQ 3612

Query: 3511 EQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
            +  EK +Q+  L+      + T  ++ E L++  +E   ++ + + ++ +     +   +
Sbjct: 3613 DHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672

Query: 3569 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQ 3628
            ++    + +   +Y                    M +K ++++  L   E+ +     +Q
Sbjct: 3673 EKISNEVLKSSPSY-------------------AMRRKIEEINNGLHNVEKML-----QQ 3708

Query: 3629 SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQ 3687
             ++  ++ Q  Q K W +E+  +  ++ E+ +  Q+I+++    ++       +   +YQ
Sbjct: 3709 KSKNIEKAQEIQKKMW-DELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQ 3767

Query: 3688 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3747
             +  +   +   L +    +EE    L S   W  +T     N A   D + T  +    
Sbjct: 3768 QVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHA 3824

Query: 3748 KTLEVLLKDMEKGHSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
             T+++ L+D E+ H+LL S   +  + ++ +    E + L + I +   Q+  L   + +
Sbjct: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIME 3880

Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSL 3862
                +++          + K++ + +++ + IL   E     P+  L   +  L   + +
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940

Query: 3863 QQT---VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEA 3919
            ++T   ++S++  ++ + + G   L + Q      + +QL  D + L ++ +E    L+ 
Sbjct: 3941 KKTIAEIVSYQVELR-LPQTGMKPLPVFQ------RTNQLLQDIKLLENVTQEQNELLKV 3993

Query: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME-EIAGFED 3978
             +K   +++ E++ +++ L   S +          SLE ++   A     ++ EI   E 
Sbjct: 3994 VIKQTNEWDEEIENLKQILNNYSAQF---------SLEHMSPDQADKLPQLQGEIERMEK 4044

Query: 3979 RLNNL-QMKGDTLIGQCADHLQAKLKQNVHAHLQG-----TKDSYSAICS----TAQRMY 4028
            ++ +L Q K D L+   A  L      N+H HL+       +D   A+ S     A+R  
Sbjct: 4045 QILSLNQRKEDLLVDLKATVL------NLHQHLKQEQEGVERDRLPAVTSEEGGVAER-- 4096

Query: 4029 QSLEHELQKHVSR------QDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL 4082
             + E +L +  S       ++ +++            EPSPQ   S  +  K ++  RA 
Sbjct: 4097 DASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRAS 4156

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL------------VQAQNL-- 4128
                    +    +    N+  +    D   TEQ  E  L            ++A  L  
Sbjct: 4157 SSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDS 4216

Query: 4129 --TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL-----NIAQNMVSQVKDFVKK 4181
               QG  E +  K+       +  + L   K + +ELEL     N+A    +   D  + 
Sbjct: 4217 SDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQV 4271

Query: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD 4241
            L+ +      ++ ++          EHK +  L +   D     N       E L     
Sbjct: 4272 LEQQLVGCQAMLTEI----------EHK-VAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320

Query: 4242 YHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA-----LQERKYAIEDL 4295
               C +  V++ L++  +E  +       S   H EAL+ + L+     + ER       
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380

Query: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL----EDLIKRKIQVSVTNLEELNVVQS 4351
              Q+Q+++E   ++ K+ +K    + ++ W Q      D  +     +  +  E +V  S
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440

Query: 4352 ----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQNL--------------------- 4383
                + Q   +W     E    I   L Q   P ++ N+                     
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500

Query: 4384 ----LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
                L D     S L+ ++ + +    + D+ + +L L   Q +       +       D
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560

Query: 4440 LVGQRRKY---------LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVS 4490
              GQ+  Y         L  ALS+K   L+       +      +      +CL     +
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620

Query: 4491 KQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEVT--EQEKSEVLGK--LQELQ--S 4541
               ++ KS +A L   ++YQNE+  L+ Q   L+K  T  +Q  +E+ G+   ++LQ   
Sbjct: 4621 AVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSKTSLQQSLNEISGQSVAEQLQKAD 4676

Query: 4542 VYDSVLQKCSHRLQELEKN---------LVSRKHFKED-FDKACHWLK------------ 4579
             Y   L+    R+ +L            L+   +  ED  D     L+            
Sbjct: 4677 AYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVT 4736

Query: 4580 --QADIVTFPEINLMNESSE--LHTQLAKYQNILEQSPEYENL----------LLTLQRT 4625
              Q D +    + L+    E   H  L + ++ +    + EN           +L +Q  
Sbjct: 4737 ESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796

Query: 4626 GQTILPSLNEVDHSYLSEK------LNALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4679
               ILPSL +   ++ +E+      L    RQ  + +     K+ +  E   + ++   +
Sbjct: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856

Query: 4680 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEG 4739
            +  T  S+S +E    R+        VE     Q   R I  + A L +    LN+ K+ 
Sbjct: 4857 LISTLPSVSLVEETEERL--------VERISFYQQIKRNIGGKHARLYQT---LNEGKQL 4905

Query: 4740 FRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
              S   P    ++  L   +  L ++ +  +  L+        + +   QL + L+S + 
Sbjct: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQH 4965

Query: 4800 EQSKVNEETLPAEEKLKMYHSLAGSL------QDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              +   E++L   + L    S   +        D    LK   I + +   HL       
Sbjct: 4966 TLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT 5025

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELS--GPV 4911
             R  +  ++ +  +L + + +   +     ++ +  +  ++  + W+  V+ + S    V
Sbjct: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSV 5085

Query: 4912 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFT---KAKELISADLEHSLA 4968
            +   +   ++  ++K +  + E+     I++ ++    +  T   ++K     +    L 
Sbjct: 5086 HSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLG 5145

Query: 4969 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA 5028
            E++     +   L  +   L ++           Q  N+WLE  +E L+       V S 
Sbjct: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205

Query: 5029 EENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTGK--EDLEQKVASLELRS 5082
            ++ L    +  +        L+EL     TL+    PL++ T    ++L QK +S+  + 
Sbjct: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQV 5265

Query: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
             ++          +Q    +W  Y +  +EV  +M        E S     S      ++
Sbjct: 5266 NQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTIRFWYCMEHSKPVVLSLETLRCQV 5317

Query: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5202
               ++L     S       L+E   +L+      ++    +   T  +RWT++     DQ
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNT-HKRWTQVNQAIADQ 5376

Query: 5203 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5262
             +  +  +  W  ++N   +A   + Q + K    +    S   L  +L      + EL+
Sbjct: 5377 LQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436

Query: 5263 QQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQEL 5322
                       Q  S+L     P P E    M     +    L+  ++     K++  + 
Sbjct: 5437 HDVQKTKEAFLQNSSVLD--RLPQPAESSTHM-----LLPGPLHSLQRAAYLEKMLLVKA 5489

Query: 5323 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK 5382
             + E V +Q                    +   +LE L+ L+     +   + +  +E  
Sbjct: 5490 NEFEFVLSQFK------------------DFGVRLESLKGLIMHEEENLDRLHQQEKENP 5531

Query: 5383 EKYLGLYTILPSELS--LQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ- 5435
            + +L     L ++      L EV+L L + D     +Q+  ++  ++ AT+ E   ++Q 
Sbjct: 5532 DSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQG 5591

Query: 5436 ------------KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
                        K  + L  I   LK    N +    +Q+           K++E + ++
Sbjct: 5592 IGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK--------TYKMLEAEVSI 5643

Query: 5484 QK-----FLEQNGQL-------GKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5530
             +     ++ Q+ QL        +P    +  KLT+  Q  ++    R   ++      +
Sbjct: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQ 5703

Query: 5531 EYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQT--LLEE--SKEIDSELEAM 5586
            ++   +E + +++     L        SA + +E++ L+QT  L+ E  +KEI  +    
Sbjct: 5704 DFTTSVENLFRFLTDTSHLL-------SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRT 5756

Query: 5587 T--------EKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
            T        EKL   T +   E + +++++L    +++   +   ++  Q   +   + E
Sbjct: 5757 TCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCE 5816

Query: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 5680
             ++K+L++ L+  +A    P      L E L + + L+ E+E
Sbjct: 5817 KKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKELIKELE 5855



 Score =  117 bits (292), Expect = 7e-25
 Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)

Query: 1237 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1296
            Y+  +K    +LI     +Q+   +I        + Q +    QK    + +  + + ++
Sbjct: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689

Query: 1297 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1351
            A+ + +GE   LP    +E+ KLE  LD   G+ R+R  +     VT  + +        
Sbjct: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749

Query: 1352 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1409
            +V+ + +   +H       S  +L +++E  K F ++   + + +QA +    A  +P  
Sbjct: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
             QN++    +  +   +VK LE+   +    ++ +  KW+ F  N+ +L       EK+L
Sbjct: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854

Query: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529
              L ++  ++ +        ++E E +L        E  SF Q +      +  A+L Q 
Sbjct: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898

Query: 1530 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1577
               G++L     C  LEG I       LS  +K +  L ++Q       S +   D+L  
Sbjct: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958

Query: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
             ++        +K  ++ +++ Q L+++ S I  F   +++V  + S      ++  Q  
Sbjct: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014

Query: 1638 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697
              L   KE  TA   L A   + E++ +  +T L   + K    +M+    R  +   + 
Sbjct: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070

Query: 1698 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1730
             +  ++++   + S +S         LLQ                  + +SL  +++ D 
Sbjct: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130

Query: 1731 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
                 +      HL +++ +W  +  ++N++I  L+ ++    + +  +   + W++   
Sbjct: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190

Query: 1786 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
              L+T  +  S++  Q  L   +D   ++  K   L  L+     L S      + LL+ 
Sbjct: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246

Query: 1845 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1903
             A    +LF++ S V+ +     + +   LQ       +  ++   T+     M  ++  
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306

Query: 1904 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1950
            ++  + L   ++N ++L+  A S +G   K Q  +             I    Q T  R 
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366

Query: 1951 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1991
            T     +  ++++ Q+LL                 KQ EA    LA +  +  +  E L 
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426

Query: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2047
             +++DI+E    +   + T++A  Q   V ++L     S  H L         +A  + +
Sbjct: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483

Query: 2048 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2103
              +  A E +  +++ +   V  +  K LI HE +       +L R +Q  K      L 
Sbjct: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536

Query: 2104 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2163
            +  ++      I+   ++       + A   +    +     T+      SEL+ I  ++
Sbjct: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596

Query: 2164 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2223
              L         +KW+ + EK+EE    L+V ++                 N +P++ E 
Sbjct: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630

Query: 2224 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2283
                      ++  K  E+EV       +   ++   L + T+ +E  P+     + L  
Sbjct: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679

Query: 2284 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2336
            + ++A +     KG +       +DFT     + +F+ D +         L++  + +  
Sbjct: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731

Query: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396
             +L + + +  EL++++ +     +   + C     A  + L   +T  +K  E+V +  
Sbjct: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784

Query: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2448
            S+ Q S ++ +E   +E +++FQ          K+  +     +VL+A+       LH D
Sbjct: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843

Query: 2449 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2501
            L N  + + + +  L + TQ   E QT+ A L++ +    V  ++EQI   + +++    
Sbjct: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903

Query: 2502 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2560
            +    KQ ++D  +    F +++++L  W+ +ME +   T ++   +     +K+ + ++
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963

Query: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620
             +F    L  ++  D+L +     S +   A  + +L +++    Q+L  +   +++  +
Sbjct: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018

Query: 2621 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2679
                  + L++ + ++  W+  I+  L+      +     ++KRL++ QD+     +   
Sbjct: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078

Query: 2680 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2735
             +       +  L  S    N+     IQ    +L   W +I + S+  +  +E     W
Sbjct: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138

Query: 2736 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
              +++  ++ E W++S ++    P   +       VL    +  L   E   R +H  + 
Sbjct: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191

Query: 2796 K---SRELYEKTEDESFKDTA 2813
            +     + Y +   E+  DTA
Sbjct: 6192 QLELINKQYRRLARENRTDTA 6212



 Score =  105 bits (262), Expect = 2e-21
 Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)

Query: 1211 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1266
            +   K   T L ++ +  SN        E    +L+    EL     +     E++L+  
Sbjct: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554

Query: 1267 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1321
             L+  +     +H++    + K++     D +  + +A    G   +   E    L+  L
Sbjct: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1381
            +  + +   + + ++  L     ++   + +   L ++ +S ++ L+  S +S++ +L++
Sbjct: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674

Query: 1382 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1441
               ++   E+   +   L  E   + L             ++ ++V KLED L+      
Sbjct: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720

Query: 1442 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1487
             M++ ++    S F T S            V I +++     L+ + S  A+  QI   K
Sbjct: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780

Query: 1488 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1547
            V  Q++   ++ ++ ++  +      +          ++T+++   E+ R+    L+   
Sbjct: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836

Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1603
               L + ++F+EN   +++ +    + L   +   S   ET + L E +   Q ++    
Sbjct: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889

Query: 1604 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1660
               + +       +++V   SC +   + A L++Q+  + ++       L+ LL H    
Sbjct: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949

Query: 1661 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1717
             ++      WLE  +   +      +++S D   +   +        EV  ++S  + ++
Sbjct: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009

Query: 1718 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1773
             +   L  +  + D   ++  L Q +++W      LP I  K        +   +   E+
Sbjct: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068

Query: 1774 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1827
            +     W+     E QT+ E S+     A      L +HK+   E++ K+  +  +   L
Sbjct: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
             +L +                     +  S+  ER + A  HL E  +    + G+L + 
Sbjct: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161

Query: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
             Q +E                    L++    E+    L+  L   +  LK   + Q+  
Sbjct: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200

Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
               +  +L  + + I+N L  K     AL  LK+++   +   +  +ED   R D+   K
Sbjct: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257

Query: 2008 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2056
                       + + Q++ Q  ++++QL DE+N       +  + +K +         +V
Sbjct: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317

Query: 2057 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2102
            +       E    E +W+  + +I + +G C  + +++ E        +  +  A++  L
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377

Query: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
            + A S++       +      A  K + AK +       L N +  G +L +E+      
Sbjct: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
            D   ++ D++ T + +L  S  L    DRL                 E  ++  +P    
Sbjct: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473

Query: 2223 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2273
            ++     +L    L+K  EFE   S+ K+  +RLE L   +     +L  L +  +  PD
Sbjct: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532

Query: 2274 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
              L  + A   Q   +EH  E++   K  L D   ++ Q     N    W      +L  
Sbjct: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585

Query: 2330 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2378
            C++      NE     CE  K ++ ++K  ++ + +++++   L    + Y   E E S+
Sbjct: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643

Query: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2438
             + +           QL   T+   +      FS+    +Q    G +        R GD
Sbjct: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694

Query: 2439 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2488
               L  +  D    ++N+   ++D    L AV  QE  +LY      H  K      Q +
Sbjct: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754

Query: 2489 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2545
             T      +A  K  L  D +  +     +   +D  + +   + EM ++F +  E   +
Sbjct: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814

Query: 2546 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2605
             ++ I E K+ +  ++    + L   E  + L    +L+ E         +   +L T  
Sbjct: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872

Query: 2606 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2639
             +L R        + KE++            +VA+++ E            E  + +  W
Sbjct: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932

Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2699
            +  +++++    + +  ++ +EK      + + +  E +++L      G+Q +++SNK  
Sbjct: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988

Query: 2700 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
               I  +L  + + W    D++ S V       + I Q +   +  + L  W+  ++ ++
Sbjct: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045

Query: 2757 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2808
              P+        + Q  L E+  L   ++   +  E        L+  S     +TE +S
Sbjct: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105

Query: 2809 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2868
             + T +  L  ++ +I  ++ E+  K+EE  +    +LD    F DWL SA+      + 
Sbjct: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164

Query: 2869 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2928
                 ++ +++L + +     R+I   RL+++E +  + ++    +  +      Q +  
Sbjct: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221

Query: 2929 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2987
              ++W++        L+  V+ +    + F+ Q  + E   E     L     QLT +E 
Sbjct: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273

Query: 2988 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3030
                + D+++ +     QEI                 +QK+EP    L + +L EL R+ 
Sbjct: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333

Query: 3031 RDL 3033
            +++
Sbjct: 6334 QEV 6336



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)

Query: 481  QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 527
            +L D  ER H   +  +  + K+E         L  +Y  LS   + ES+  + +     
Sbjct: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749

Query: 528  -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 585
             +K G+ +     L+   S +      E ++V +Q  K  A+M +    S +   ++++ 
Sbjct: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807

Query: 586  ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 629
               F  E   + + L  + R     L+ ++  W+ +    ASL+             + +
Sbjct: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867

Query: 630  EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 685
            E+ E+ L +  +  +   RN+     + +  +N+    +   +C E+  +   L++Q L 
Sbjct: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927

Query: 686  LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 738
            LN        R + L   +  Y +  + D++ K       TL+ +  E    +S+ L+  
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984

Query: 739  FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 798
              N+    +  ++++++  +  A   I  +  HL  KE+     +   A   +    L  
Sbjct: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042

Query: 799  VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 856
                    L++ Q   +P  +   +M S+ +++         +   + +S +    QKH+
Sbjct: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102

Query: 857  ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 916
            E    +        +++  +QS+ +  T     K +++T     + +++  +  +     
Sbjct: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159

Query: 917  DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 975
               +H+E     + + E     L   L   +E L+    PE ++          D +  L
Sbjct: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219

Query: 976  NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1006
                KA DEL                             + +L +  Q  L+ +++ + +
Sbjct: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277

Query: 1007 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1058
            +WK    L  E     +     +E ++  + S+E  R +++    L  +    EGS + +
Sbjct: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337

Query: 1059 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1118
            +E  V    KG   LC    ++IEE C                H    ++  AI    +K
Sbjct: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379

Query: 1119 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1174
                   WK Y++   E ++ +   E + + +   ++   N  E+     + ++E+++ V
Sbjct: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439

Query: 1175 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
             K  E     S +  RL    E S+          L + +   K L+   +E E +LS F
Sbjct: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499

Query: 1232 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1287
             D        K ++ +  E L    ++ +E  +  L+      AQ   + H  +   +  
Sbjct: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558

Query: 1288 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1343
               DV  +  Q    +             + +T   LER  E Q      +      KW 
Sbjct: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605

Query: 1344 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1403
                          Q     E  L      SL   LEQ K +        ++AE  + + 
Sbjct: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646

Query: 1404 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1452
                   Q+ QLL     +       +  KL D  +  ++ +   K        +W  F 
Sbjct: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706

Query: 1453 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1512
            ++ E L  ++T+    L+A++         + Q +  I E+++K    +  +    + A 
Sbjct: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760

Query: 1513 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1569
             +  GE   +   L     + R   +L++  + +E  +   + Q Q   E   + ++ + 
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820

Query: 1570 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1619
            E + +L V +K  S     E ++ L    +L + LE        +L    T  +   R V
Sbjct: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879

Query: 1620 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1677
            +  D  V  ++   L +Q+ED+  R   R+  +E+ L  W    ++      WL + E K
Sbjct: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939

Query: 1678 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1733
                  DIS +        ++I+ LQ + + + + +S    +L Q+ + L   ++K    
Sbjct: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990

Query: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
             +   L ++++RW+ L  +I  R+  L+   A  QQ D+ + +   W+    SEL     
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050

Query: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1846
              + D Q           E++ +  E Q LQ     H A + S+    D+ L    A   
Sbjct: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099

Query: 1847 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1891
            E      ++ ++ ++RR   +  ++               +FL  ++     L+   +T 
Sbjct: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159

Query: 1892 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1951
               NS     S+++     + L+  +A +         L       +  + E RT   + 
Sbjct: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214

Query: 1952 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2005
              Q+  E  +R  NL    Q    A+    + F +Q+EE   + E I     E       
Sbjct: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270

Query: 2006 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            ++  +      ++R  N  + E+  + +++  L    +Q+ QK
Sbjct: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313



 Score = 90.9 bits (224), Expect = 5e-17
 Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)

Query: 6582 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6637
            NQN+    ++E+  ++      TGQ K+A D + ++   E    E + +LD+        
Sbjct: 713  NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761

Query: 6638 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6694
                   +T   + +   + K + F  ELMA++  +L+   +        +++L T    
Sbjct: 762  ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814

Query: 6695 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6754
               + +   Q+ VV+       L + + D  +D     +  +  L  Y  +  Q+L   +
Sbjct: 815  KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872

Query: 6755 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6809
                  S  +L S+  +     +SNT  ++K L  +E +  + T       + +S D+  
Sbjct: 873  ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924

Query: 6810 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6869
              +S    L  + QQ + +  E   + D++   L+  K+++ +  L             +
Sbjct: 925  KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967

Query: 6870 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929
            ++  T  L  E     S+    L  +    E L +L  ++LPS+ +  EV     L+++ 
Sbjct: 968  RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022

Query: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
             QK E  +K +     IH  LQ   G     N   +T            +   +S     
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078

Query: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 7035
            T+ A +         +L+ L  E I        +  LLE +  Y        +NN   + 
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138

Query: 7036 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7095
            + F ++E R          + +Q  L D Q +++   A+ KE E I       + + K+ 
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190

Query: 7096 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
                   TL+E   +    L+  +  L+  L+ VL      K +     S L   + ++ 
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247

Query: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
             F L+    +A ++   +L+N+QD + KQ     +     N +LKE HP     + N + 
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302

Query: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
            +   ++  +   +     + KAL       +D+     +     E  T+    +A++  +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352

Query: 7275 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7331
            A +   T      +  L+K      D    + ++  +  ++  D S  + + +  + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412

Query: 7332 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7384
             H   +++   ++   L+A +       K+++ +++ I +    +  +DP+         
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468

Query: 7385 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7444
             L  + + ++E + +      MA  L    + G    +N ++ +    L  +   + ++ 
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526

Query: 7445 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7501
             E+  ++   L Q+Q F    ++ +  L+Q E+ + + +  +Y   ++L ++    E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581

Query: 7502 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7558
             E     ++   ++ +  + Q  L + +  +   F  +  ++ ++W  +  + +     +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641

Query: 7559 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7618
               +  W +   +   + +W  +             + L Q  T  D  + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691

Query: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7672
             +   +    +   L   S     LQ   + I  K +     L  +          A L 
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751

Query: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7728
            +D ++ +  I  +   L+      S  +    EE+  + ++ K     LEN +G  T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811

Query: 7729 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788
            ++L    +++S         + N +  +LQ  + +L +          +  N+W  FS  
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854

Query: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7843
               L E     E+K S      +E+ ++KL      E    + +KI+     L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905

Query: 7844 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7900
             KA  +   S +   E++L K+         +  AR K+L+++L  + +L  +  +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958

Query: 7901 LAHIE------------------------------------------SELAKPIVYDSCN 7918
            L + E                                          +E  + I+  +C 
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018

Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978
             +  Q  L +  E++ + +   T   S  +L   ++H            +  +    L+ 
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078

Query: 7979 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
            R    + I  +  E   +IE   +        L QK L D S    W  +    + + S 
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136

Query: 8028 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 8070
                   G  Y  +KE       ELKK +    A Q  + E   QL++  K  ++     
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191

Query: 8071 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
              D    LK++  +GN             + W  ++    S+L++L+  +   +      
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251

Query: 8118 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8168
            DS  V +T+++  L N   E  S  D       V+ K+++L+  +  +SL    +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8211
              + + + +  +   II++++  L+                   C     + +R  +K  
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371

Query: 8212 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8268
            +  LP  E    SD +   ++SAA+  L   W + + DS +    S  LSL+  + +++ 
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430

Query: 8269 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8317
               R     + + PLE D             L   LE+  +   P E  E   + +    
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489

Query: 8318 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 8376
            +   +G S  H   L   +  L K  +     ++  +  + +   +   L T  +     
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549

Query: 8377 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 8423
              +  + +D +K+    +++E++SL         ++ H T       E+Q   +   WE 
Sbjct: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609

Query: 8424 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 8483
            ++ Q   K     Q + ++ +F + +N +     DTE  L+Q Q+           LQ+ 
Sbjct: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651

Query: 8484 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 8529
            +LK  ++   ++  I L+ +L + +        QA+         KE ++L+D ++ +  
Sbjct: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711

Query: 8530 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 8589
            +W+     LE      ++ + +C   ++M    +L  +N+    N  +P+   L  +IL 
Sbjct: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763

Query: 8590 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 8645
               K   ++ H+ +L  Q  V SL +        L   EG+D     E +    N+ ++L
Sbjct: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818

Query: 8646 LKEVSRHIKELEKLLDVSSS 8665
            + + ++  ++LE  L+  S+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSN 2838



 Score = 79.3 bits (194), Expect = 2e-13
 Identities = 565/3062 (18%), Positives = 1152/3062 (37%), Gaps = 460/3062 (15%)

Query: 5160 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
            V L E  +Q  K G    K           + +T    VA+D EK++   V+ W      
Sbjct: 706  VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755

Query: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5276
            V    ++   +++ L    A+ +   EL+   E  D   ++++    Q+S   +L     
Sbjct: 756  VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813

Query: 5277 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5334
            + +Q+           L+  +  + D    L+++ K++ + K ++  +   + +  Q  S
Sbjct: 814  AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873

Query: 5335 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393
                + + KE L  + T  +   L+ ++ L    T   ++I+   EE+       +  L 
Sbjct: 874  PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930

Query: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453
             ELSL + ++ +D++ + ++ D I ++E+     ++L R+ +   K L        ++  
Sbjct: 931  HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987

Query: 5454 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504
             + Q     +VL    EEL    S+      L + +  +++ L+   ++   L    G  
Sbjct: 988  CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046

Query: 5505 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5564
            T  ++ TI  +ENR    +  A   +  N+         EKA      T+ ++ AS LR 
Sbjct: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097

Query: 5565 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5621
              +  ++++E  K+  + + ++ E+      +   +      +  ++   E +     ++
Sbjct: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153

Query: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5678
             +L +LQ    +      E + +   LE     +  P V   R +LKE+    Q  L + 
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213

Query: 5679 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5729
            MESL+  ++ V         LC S L + +  +    L  A  R+ +    +Q +  +Q 
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272

Query: 5730 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5763
              CN                    MQ  +++Y+   + M H  Q  E   + +ED     
Sbjct: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332

Query: 5764 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
                ++   + +L A  ++  +E    +K  + +I  +  K K L    K   M     E
Sbjct: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392

Query: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5875
                      LD   +     H   V       + LL     ++ E     +   S+IS 
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452

Query: 5876 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5934
                + P     T  +V         L     + +  K H    A S   ++ G E +  
Sbjct: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506

Query: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5992
             +  +    WE  K +++E        LE  ++YQ+    ++T ++  E  + L  S   
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566

Query: 5993 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQ-------- 6040
              + + ++AE + + +E    L + D+IN++  +L   L   ++ E  P E+        
Sbjct: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626

Query: 6041 ------------------LALQSTLTVLAERMSTIRMKASGKRQL--LEEKLNDQLEEQR 6080
                              LAL   L  L   +     KA  K +L  L E+  ++L+E+ 
Sbjct: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686

Query: 6081 Q--EQALQRYRCEADELDSWLLSTKATLD---------TALSPPKEPMDMEAQLMDCQNM 6129
            Q  EQ    +     E+   L S++  L+           +   ++ +  E+        
Sbjct: 1687 QVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGS 1746

Query: 6130 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA--LHDKQ 6187
              E+ + +          E+LL   KA +  ++ ++  KL  ++  +L+ + +  L + Q
Sbjct: 1747 TAELREDLDQAKTQIGMTESLL---KALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQ 1803

Query: 6188 LNM----QGTAQEKEESDVDLTATQSPGVQ---------------EWLAQARTTWTQQRQ 6228
            +          +++ ES  DL  T+   +Q               +W +  +    +  +
Sbjct: 1804 IGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFE 1863

Query: 6229 SSLQQQKELEQEL----------------AEQKSLLRSVASR--------------GEEI 6258
            SS + +K +EQ+L                 +  S+L+ V                 G+E 
Sbjct: 1864 SS-ETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF 1922

Query: 6259 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE---DQMRMKWESLHQEFSTKQKLLQN 6315
             ++   +     A E  D L Q L ++ +  +          KW+ + +E   K +L   
Sbjct: 1923 ELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM-EEPGEKTELFCQ 1981

Query: 6316 VLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6375
             L +++EQ  +    +L + +  Y      +     T L+D       ++S      K  
Sbjct: 1982 ALARKREQ--FESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLL 2039

Query: 6376 SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD- 6434
                +Q   D       W+ +++E L V   L   E +  L  +    K+I  +  E D 
Sbjct: 2040 PTE-DQSFNDLAHDVIHWIKEIKESLMV---LNSSEGKMPLEERIQKIKEIILLKPEGDA 2095

Query: 6435 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRL-SLLDSVVNQRCHQMKERL--QQILNFQN 6491
            + + +  QA         +++ TL  +  +  + L        HQ K  L  ++ L  + 
Sbjct: 2096 RIETIMKQA---ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152

Query: 6492 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6551
            DL+++   L   +         + E+    Q++  ++     ++  + + ELK +G+ L 
Sbjct: 2153 DLRLMLIELKKKQEAGFALQHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLL 2210

Query: 6552 --VEQPSMQE--LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
               + PS  E    +++ +++ L+  +      L+ ++     Y+  + DL   L+   +
Sbjct: 2211 ECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSK 2270

Query: 6608 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA--VQKETQFHTE 6665
            +      +  S K   Q  +++  +  Q LE+ + L +   +KI++ A  V++ T    +
Sbjct: 2271 EF-----VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQ 2325

Query: 6666 LMAQASAVLKRAHKRGVE-------------LEYILETWSHLDE------DQQELSRQLE 6706
             + +      +  ++ +E             L  IL++    ++        +E     +
Sbjct: 2326 KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSD 2385

Query: 6707 VVESSIPSVGLVEENEDRLIDR---ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6763
            V ES+  S  + +  ED  I++   + +    + SLN  Q  +    D+ K   +     
Sbjct: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA-QESMKNTEDERKVNELQNQPL 2444

Query: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ----SESADLI-HWLQSAKDRL 6818
            +L++ L       L    K+  +L   +  +K   + +    +E+  L+ H +  +   L
Sbjct: 2445 ELDTMLRNE---QLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHL 2501

Query: 6819 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
            +   Q  +T+ +  E     L  F E+   V  +SS+K+  L T  + L++  +D+ T  
Sbjct: 2502 DNLLQALITLKKNKESQYCVLRDFQEYLAAV--ESSMKA--LLTDKESLKVGPLDSVTYL 2557

Query: 6879 SELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKD 6933
             ++ +  +   +  D L N+    E L  H   MDK      I ++      +E  IQK 
Sbjct: 2558 DKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKK 2617

Query: 6934 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 6993
                +  + Y      + K +  +I +  +Q  +       L++ S +  +         
Sbjct: 2618 YS--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALT 2669

Query: 6994 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIG 7052
              L A    + +L+G    +++ + G  E     E+ +  LK  +ET E   L+ +++I 
Sbjct: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI- 2727

Query: 7053 DQASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQ 7083
             +  ++N +K+                             C+   D I A+++ VE + +
Sbjct: 2728 KKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAE 2787

Query: 7084 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7143
                 + +      S + +TL +L   +  L     Q    L+  L++ S+      K  
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847

Query: 7144 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7203
              + E+  +L   R+ T + EA       L++    LE  ++ LQ+  S  +  L+E   
Sbjct: 2848 LMVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE--- 2897

Query: 7204 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY--------KDYSKQC---- 7251
                 LTN  +E+N+     LE   +QL++ K      QR+        +   K C    
Sbjct: 2898 -----LTNIYEELNVFERLFLE---DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFH 2949

Query: 7252 --ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHEL 7306
               S +Q++ D   R   LL    NK + ++     I +  D L  +      +  L ++
Sbjct: 2950 EKTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKV 3004

Query: 7307 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 7366
             + +    D S    +Q+      + L    +   KQ  + +     Y+     + A++ 
Sbjct: 3005 FDYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060

Query: 7367 WIVE-AEEILQGQDPSHSS---DLSTIQERMEELK---GQMLKFSSMAPDLD------RL 7413
             I +  E +L+  D S  S   +   + +R+E+ K    +++K  +     D       +
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120

Query: 7414 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
             ++      NDK  K +QN+                +L    L  +   +K ET +  L 
Sbjct: 3121 LQIKLNAEENDKLYKVLQNM--------------VLELSPKELDEKNCQDKLETSLHVLN 3166

Query: 7474 QTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSI-IIDGQRLLEQGQVDDR 7530
            Q + +L   +  N +  H+  ++   E FQ ++++    + ++  I+ QR     +  D 
Sbjct: 3167 QIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASD- 3225

Query: 7531 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 7590
                 KL    +    +      R  +++       RY+E   +        +   ++ L
Sbjct: 3226 --VETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTR--------AVESITSL 3275

Query: 7591 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQ---- 7644
             ++ IP    R      +   ++ LR+Q     TV   + L   L   S  EA LQ    
Sbjct: 3276 EAIIIPY---RVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYT 3332

Query: 7645 -AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 7703
              EL       K A    E + ++     K + K E+ I  +L K+ T   +   SLP  
Sbjct: 3333 LQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLS 3392

Query: 7704 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7763
            + E      + K L + + S  ++L +L  +   L    + +D   L + V  L  +W  
Sbjct: 3393 YREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLS 3452

Query: 7764 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 7823
            L            E   EW ++ E+ K+  EW  +  S+  +   I+++ + E+L     
Sbjct: 3453 LL-----------EAAKEWEMWCEELKQ--EW--KFVSEEIEREAIILDNLQEEL----- 3492

Query: 7824 EEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK-- 7881
             EI+  +E            A     S+  +   + G+  ++ Q LL L+  R++ ++  
Sbjct: 3493 PEISKTKE-----------AATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNV 3541

Query: 7882 -------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 7934
                   ET+ A Q++          L  ++            N E +Q ++ E+    +
Sbjct: 3542 PESSGAVETVPAFQEITSMKERCNKLLQKVQK-----------NKELVQTEIQERHSFTK 3590

Query: 7935 DI 7936
            +I
Sbjct: 3591 EI 3592



 Score = 67.0 bits (162), Expect = 8e-10
 Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)

Query: 7065 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7111
            + L+ L+K  E +    + N L + +++  E+  S   V+S  R+L +           W
Sbjct: 311  EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370

Query: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7171
              LDH +   KI L   L        A+ +    LM+   S S+    + ++  +Q ++ 
Sbjct: 371  DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428

Query: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7227
              ++L D  E     L     +T +   E H P+     N L+E+  R NN+LE+    +
Sbjct: 429  LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481

Query: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7283
             E       +L L    K  SK     ++     + ELL    +K I + E    + T  
Sbjct: 482  LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539

Query: 7284 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
            Q C ++ K L                      A     I    + +   +C   + +   
Sbjct: 540  QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577

Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
            +++LQ  +  + T+ ++L  L A   E                 T +E ++E+  + L  
Sbjct: 578  KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620

Query: 7404 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7457
             ++  +   LNE G  L     ++      K ++ LN+ W  + S+T    +       Q
Sbjct: 621  WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678

Query: 7458 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7513
             Q   +     +    +  V+    ++VE+  NY   ++    HE    E   + ++   
Sbjct: 679  DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737

Query: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573
               D ++L+ Q ++                W+       + + ++D    Q      M E
Sbjct: 738  ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768

Query: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7633
             L+  + + S                   +FDE+  + +  L+     I + E+ + +L 
Sbjct: 769  SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809

Query: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
            +        LQA++ E +EK +   ++L    K L  +  D +   K + +S ++L ++ 
Sbjct: 810  T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861

Query: 7694 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7753
             +  Q L          ++  K  E  + S T  L +     + L   ++ D    L E+
Sbjct: 862  MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918

Query: 7754 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7813
               +  +WE L H+LSL  QQ+        +  EK K L + + ++E ++++   ++   
Sbjct: 919  SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970

Query: 7814 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872
              + L K++  E   ++E  + QL    E L +   E  + + + ++ ++   ++  ++ 
Sbjct: 971  RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028

Query: 7873 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932
            +   +K   E  + +Q      S     +   E+    P      +SE    K + Q   
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079

Query: 7933 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7990
            ++ +E      +ASVL  L E  + + D  A      SI       D  +R+I    +E 
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128

Query: 7991 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 8050
             L+  +      +   D+S  ED  +SS    A  +   VI        K+FE    ++ 
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181

Query: 8051 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8110
              +     I K +    R+   +    L+  +   N R ++L+  +  +L          
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225

Query: 8111 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8170
                  + S+L+  +++ L    I+ F   D     + L+  Q  I+       ++   G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282

Query: 8171 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8230
              ++++  P D   ++  + + +   + +  RV+R    L                    
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322

Query: 8231 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 8289
               AL D     R+A   LS +P ++LS S  Q  +    + ++    +  +  +  H  
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378

Query: 8290 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 8348
               + L+ +   A   +D   ++  D +   ++ LS  H   ++ +  +  K L+   F+
Sbjct: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435

Query: 8349 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 8398
                      +Q   + I  K PT P +    K  ++L       +D  +  +  L+E  
Sbjct: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491

Query: 8399 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8453
             SLP F +    +   Q    +  WE    L  + L +  R+ + L+++Q F S L +  
Sbjct: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549

Query: 8454 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 8505
              L   EE +  LQ     +  L   I  IE+  ++  E  + VD    +  ++      
Sbjct: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607

Query: 8506 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 8547
                  P F +            ++++ D  + L +    WD++ +L   ++EW     +
Sbjct: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663

Query: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 8607
              +Q    H+++       E+ +R K E+      +  +   +  +++ +I+  L  S++
Sbjct: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712

Query: 8608 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 8663
             +  LQ M   +L   E    CL  +   H +      L+  L +    I   E LL   
Sbjct: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771

Query: 8664 SSQQDLSSWSSADEL 8678
            S    L  ++  +E+
Sbjct: 1772 SPSDSLEIFTKLEEI 1786



 Score = 57.8 bits (138), Expect = 5e-07
 Identities = 88/534 (16%), Positives = 217/534 (40%), Gaps = 51/534 (9%)

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
            + +  GE+ L +++ + +  +  ++  L++ W D+           +S +  W+   ++ 
Sbjct: 5760 LTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKI 5819

Query: 2743 NQLEQWMESVDQKIEHPL-QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
             +L+  ++ +  + E PL +    L  +  L+  L+  L+    + + L  + A     +
Sbjct: 5820 KELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR-H 5878

Query: 2802 EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKE 2861
               ED        E L  Q+ D+      + +++E+ +   +++ +   E   WL   + 
Sbjct: 5879 VLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938

Query: 2862 ELHRWSDMSGDSSATQKKLSKI-KELIDSREIGASRLSRVESLAPEVKQNTTASGCELMH 2920
            ++ + +D+S      ++ + K+ K+ ++   + +    +++ +  ++ + +  S    + 
Sbjct: 5939 KVLQTADIS-----IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEID 5993

Query: 2921 TEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWA 2980
             ++  +   W+   D +    S ++ L    A  +Q            L++  + L+TW 
Sbjct: 5994 DKLNKINDRWQHLFDVI---GSRVKKLKETFAFIQQ------------LDKNMSNLRTWL 6038

Query: 2981 QQLTLLEGKNT------DEEIVECWHKGQEILDALQKAEPRTE------DLKSQLNELCR 3028
             ++     K        D+EI +   + Q++   +++     E      D+    ++ C 
Sbjct: 6039 ARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACA 6098

Query: 3029 FSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQI--LQQRFRKAFRDFQQWLVNAKIT 3086
               +  +       L + +  +C  + +     E+   L Q+F   +  F+ WL +A+  
Sbjct: 6099 NETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAE-R 6157

Query: 3087 TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTK-------EK 3139
            TA C     N SEV  +  K  E L   E  Q +++  L++ EL++    +       + 
Sbjct: 6158 TAAC----PNSSEVLYTSAK--EELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDT 6211

Query: 3140 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE 3193
            A  ++  V    + W N    +      L +   Q ++FE + E I  WL++ +
Sbjct: 6212 ASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265



 Score = 41.2 bits (95), Expect = 0.046
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 8421 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
            W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 305  WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361

Query: 8481 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
               +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 362  DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421

Query: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
            L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 422  LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459

Query: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8644
               ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 460  --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517

Query: 8645 LLKEVSRHIKELEKLLDVSSSQQ 8667
            LL++  + I+E E L  + +S Q
Sbjct: 518  LLEDWHKFIEEKEFLARLDTSFQ 540



 Score = 39.3 bits (90), Expect = 0.17
 Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)

Query: 316  DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 374
            ++ + KE++  +  + ++L   Q ++++L       +H  V+  M  K QIEHL    HR
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896

Query: 375  DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 431
              + L L  A+ KQ    +  RL  W +  +K+       + AWL + E  V    +I++
Sbjct: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948

Query: 432  QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
            +++ E+       ++    +   N    K+   ++ +  + +      D+L  + +R+  
Sbjct: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005

Query: 492  VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 542
            +       + K   L+  +  +  L    S L++W+ +     S          +++ + 
Sbjct: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062

Query: 543  YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 599
                 +  +  EQ+    + +    ++ +    A  +  E +++ +       +WRN+  
Sbjct: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122

Query: 600  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 646
                 R  +EE    W ++ +  +  + WL+ AE+     N SE    +AK++      F
Sbjct: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182

Query: 647  FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 705
             R +   + Q   +N     L        +  LKQ +   N RW  L   V     +   
Sbjct: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242

Query: 706  MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 764
                ++E+     ++  + TE   +L+     S  +    ++ L   +Q + +   +  +
Sbjct: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302

Query: 765  IITKTAHLITKESP 778
            +I     LI K  P
Sbjct: 6303 LIVFGEQLIQKSEP 6316



 Score = 35.4 bits (80), Expect = 2.5
 Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)

Query: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
            +K       S+   ++ W+ + E EL  L+ +    D+Q  +++V  +QEI    ++  +
Sbjct: 6572 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6631

Query: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1558
             +V +   ++ F Q   + ES  ++++L Q+    E  +       G +   L Q Q F 
Sbjct: 6632 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6690

Query: 1559 E 1559
            +
Sbjct: 6691 Q 6691


>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
            [Homo sapiens]
          Length = 6885

 Score = 2049 bits (5308), Expect = 0.0
 Identities = 1743/6321 (27%), Positives = 2982/6321 (47%), Gaps = 546/6321 (8%)

Query: 2749 MESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--LYEKTED 2806
            +  V   ++  L+ +   KE    +   Q +L + E        LI+K +E  +   T+ 
Sbjct: 837  LTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGE----LISKHKEALIISNTKS 892

Query: 2807 ESFKDTAQEELKTQFN-DIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2865
             +    A EELK     DI    +EK R V    K   ++    HE + ++   K ++ +
Sbjct: 893  LAKYLKAVEELKNNVTEDIKMSLEEKSRDV--CAKWESLH----HELSLYVQQLKIDIEK 946

Query: 2866 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC--ELMHTEM 2923
               +S +    +K+++K K+LI        R  R + L  E +   +  GC  +L H  M
Sbjct: 947  -GKLSDNILKLEKQINKEKKLI--------RRGRTKGLIKEHEACFSEEGCLYQLNH-HM 996

Query: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQL 2983
            + LR   ++      ++Q  ++ L+       +      +++   L+  +         +
Sbjct: 997  EVLRELCEELPSQ--KSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTI 1054

Query: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE-DLKSQLNELCRFSRDLSTYSGKVSG 3042
            T  E +  D      + K        +  EP  +  L S L  L   S     YS  ++ 
Sbjct: 1055 TTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINS 1114

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
            L++ Y+          QN +  +   F     D     + AK+T  +   + +N ++   
Sbjct: 1115 LLERYDTYRDILEHHLQNNKFRITSDFSSE-EDRSSSCLQAKLTDLQ---VIKNETDARW 1170

Query: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
               +I     E+     K   ++ + + L     KE+ + +Q  +    E  +     + 
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTL-----KERERELQMTLNTRMESLETALRLVL 1225

Query: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE-----QQKLQ 3217
              E A  +L +   D  +    IQ +       +++    + D  AK+ E     ++   
Sbjct: 1226 PVEKA--SLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGN 1283

Query: 3218 SVLEEIHCYEPQLNR---LKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN-------- 3266
             VL+E+H ++    +   LK K Q  +EG        HRV +      AL +        
Sbjct: 1284 FVLKELHPFDLHAMQNIILKYKTQ--FEGM------NHRVQRSEDTLKALEDFLASLRTA 1335

Query: 3267 -LTKEKVSRL---DRIVAEHNQFSLGIKELQ-DWMTDAIHMLDSYCH------------- 3308
             L+ E V+ L   D  VA+ N  ++  KE +   M D    LD                 
Sbjct: 1336 KLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGD 1395

Query: 3309 PTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV-- 3366
             TS +++LD+ ++KL        ++E   +  +        N   + I  +Q Q+  +  
Sbjct: 1396 DTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGL 1455

Query: 3367 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG----WMDSMEANLNESERQHAEL 3422
            KD     +    +   +L+  L ++   +  +++ +     + D  E  +N+  +    L
Sbjct: 1456 KDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVL 1515

Query: 3423 RDKTTML--------GKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYR 3474
             + T  L        G+   L ++  ++ S+L T+  K   +     + +  ++L++R  
Sbjct: 1516 WENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIA 1575

Query: 3475 AIQ------ERAKEAVTKSEKLVRLHQEYQRDLKAFEV-------------WLGQEQEKL 3515
             I+          E V K  ++ +  Q Y   +K FE              WL   ++  
Sbjct: 1576 EIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTE 1635

Query: 3516 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3575
            D Y  L G A      L +L+ +     E +AL    LH   +         EDR  E L
Sbjct: 1636 DYYENL-GRALALWDKLFNLKNVIDEWTE-KALQKMELHQLTE---------EDR--ERL 1682

Query: 3576 RQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE 3635
            +++ Q ++ + SE    F+  V +++ + Q   ++   L+  E  +  +        T E
Sbjct: 1683 KEELQVHEQKTSE----FSRRVAEIQFLLQS-SEIPLELQVMESSILNKMEHVQKCLTGE 1737

Query: 3636 IQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLE 3695
               H +     E+   R+++++  A+ Q  + ES + +     + ++ ++ + +  Q+L+
Sbjct: 1738 SNCHALSGSTAEL---REDLDQ--AKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQ 1792

Query: 3696 ----------QIKFLEEEIQSLEESESSLS-----------------------SYSDWYG 3722
                      QI  L  E+  L++   S+S                       +++DW+ 
Sbjct: 1793 QKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFS 1852

Query: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
            +   N K      +   +V   +KL+ L   L  +E  +S +K      +   K+L +  
Sbjct: 1853 NIKVNLKECFESSETKKSVE--QKLQKLSDFLT-LEGRNSKIKQVDSVLKHVKKHLPKAH 1909

Query: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
             + L   +     +L+++ S  +     LE  L       D  + L +W+   +E     
Sbjct: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969

Query: 3843 EEP--KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQ 3900
            EEP  K EL+ +   L++ +   ++V     S+K      E   E++ + T    +D+ Q
Sbjct: 1970 EEPGEKTELFCQA--LARKREQFESVAQLNNSLKEYGFTEEE--EIIMEATCL--MDRYQ 2023

Query: 3901 SDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETIT 3960
            +  + L  I +E     +    + + +N    +V  W+ ++   L+  +  E        
Sbjct: 2024 TLLRQLSEIEEED----KLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEG------- 2072

Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC---ADHLQAKLKQNVHAHLQGTKDSY 4017
                  K  +EE       +  L+ +GD  I      A+  +A L Q     +    D+ 
Sbjct: 2073 ------KMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNT 2126

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVK 4077
              + ST     + L  E +K++  ++ L+     L   Q +   + Q  L   +A  Q+K
Sbjct: 2127 LHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ-EAGFALQHGLQEKKA--QLK 2183

Query: 4078 HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKH 4137
             ++   ++A+    LL  +    N  ++ T       E                W EIKH
Sbjct: 2184 IYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEP---------------WLEIKH 2228

Query: 4138 LKSELWIYLQDADQQLQNMKRRHSELEL----------NIAQNMVS---------QVKDF 4178
            L   L   LQD+ Q L    R H   ++          N ++  VS          V++ 
Sbjct: 2229 LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK 2288

Query: 4179 VKKLQS-------KQASVNTIIEKVNKLTKKEESPEHK----EINHLNDQWLDL------ 4221
            ++KLQ        +  ++  I+     + +   S   K    +I  L  +  DL      
Sbjct: 2289 LQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLAS 2348

Query: 4222 CRQSNNLCLQREEDLQRT-----------RDYHDCMNVVE-----VFLEKFTTEWDNLAR 4265
             +Q    CL      +R+           R+     +V E       +EK   +W+    
Sbjct: 2349 AKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEI--- 2405

Query: 4266 SDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW 4325
               + +AV +   K+L+L  QE     ED +   +   + L LD   L  EQ   +E+ +
Sbjct: 2406 --NKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTM-LRNEQLEEIEKLY 2462

Query: 4326 FQLEDLIKRKIQVSVTNLEELNVVQSRFQEL--MEWAEEQQPNIAEALKQSPPPDMAQNL 4383
             QLE   K+     +   E LN  ++    L  + ++ +   N+ +AL        +Q  
Sbjct: 2463 TQLE--AKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC 2520

Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADL--GLNERQVIQKALSDAQSHVNCLSDLV 4441
            ++        L A +  +K+L+ D + +       +     I+K ++  +   + L +L 
Sbjct: 2521 VLRDFQ--EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLK 2578

Query: 4442 GQRRKYLNKALSEKTQFLMAVFQATS----QIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
             +     N       + L +  +       Q++Q  +K   ++ +    D+ +  +   +
Sbjct: 2579 IKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEY--DEFTTLMNKVQ 2636

Query: 4498 SAQASLKTYQNEV--------------------TGLWA--QGRELMKEVTEQEKSEVLGK 4535
              + SL+  Q  +                    T L A   G  ++K   E +   + G+
Sbjct: 2637 DTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGE 2696

Query: 4536 LQELQSVYDSV--LQKCSHRLQELE---KNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4590
             +E +++ D +  L+K    L+ L    +N + +   +    +   W K       P I 
Sbjct: 2697 -KEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIP 2755

Query: 4591 LMNES--SELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNAL 4648
            L+ +   S++      +  IL +    E+L   ++      +PSL   + S L+  L  L
Sbjct: 2756 LLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDK----VPSLTTYEGSDLNNTLEDL 2811

Query: 4649 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFL-RMSKVPTDLAVE 4707
              Q+ ++V  +  +  +++  +  R  + ++I      + E E   + R+    T+  ++
Sbjct: 2812 RNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELK 2871

Query: 4708 EALSLQDGCRAILDEV-AGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT 4766
                  +  +  L E+ +G+   + EL    E      + +  D++ +L    +R++R  
Sbjct: 2872 HHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQR-- 2929

Query: 4767 EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE-ETLPAEEKLKMYHSLAGSL 4825
                  +++T +  +   K C+Q   +  +++EE   +   E L  +E  K       +L
Sbjct: 2930 -----FIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984

Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
            +D    +K   + +  L    D +       Q+   Q ++      + E + + ++   +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE 3044

Query: 4886 SIDFQTEMS--RSLDWLRR------VKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4937
               +Q  +S  R++D   +      +KA  S P    LN Q + + I K +   +E+   
Sbjct: 3045 HGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKK 3104

Query: 4938 LRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELS--ELDG-DIQEALRTRQAT 4987
            L          KEK     +L + +       L++ + ELS  ELD  + Q+ L T    
Sbjct: 3105 LNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV 3164

Query: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
            L +I SQ Q+   +            E+  +     + E+ +E + + M           
Sbjct: 3165 LNQIKSQLQQPLLI----------NLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEK 3214

Query: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKV-ASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5106
              EE  S  + ++  ++    EDL+ ++  S++LR+  ++       D  +  T     Y
Sbjct: 3215 QREENSSEASDVETKLREF--EDLQMQLNTSIDLRTNVLN-------DAYENLTR----Y 3261

Query: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA 5166
            ++A    +E +   E  +  + +   +     E  L + + L S V         +++  
Sbjct: 3262 KEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV-------AHIQDLT 3314

Query: 5167 SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5226
             +L    +  +K  L  ++  +  + + ++   + QE   E  ++ +  +    +     
Sbjct: 3315 EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTN 3374

Query: 5227 IDQLQDKLPGS-SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAP 5285
            + +++  L  S S+   S  E L  LE     V  L   +  L  LRQ  L +L+     
Sbjct: 3375 LSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ-ILRLLR--LRC 3431

Query: 5286 TPGEEPPLMQEITAMQDRCLNMQE----------KVKTNGKLVKQELKDREMVETQINSV 5335
            T  +   L++ ++A+ ++ L++ E          ++K   K V +E++   ++   +   
Sbjct: 3432 TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEE 3491

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTIL 5392
               + +TKE          A  EEL  LL     + +N+EK   +     ++   +  + 
Sbjct: 3492 LPEISKTKEA---------ATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542

Query: 5393 PSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK 5451
             S  +++      ++  ++++    +++V+++K   Q   ++     K++  +    +  
Sbjct: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602

Query: 5452 TDNVVQ-AKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5510
            T +    A  D     E+ +   S L +     +  +E          K   K +E++  
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIME----------KLRIKYSEMYTI 3652

Query: 5511 TIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 5568
               + E+++ +  +A   ++E   NE+L+    +  + K+        N    L+++   
Sbjct: 3653 VPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712

Query: 5569 HQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------RETEELRQM 5619
             +   E  K++  EL+    KL  L S      E+   Q  E         ++ +++ Q 
Sbjct: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772

Query: 5620 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 5679
             + R   L  A   M+++   LK  +A +E     L +P          LSH  H  +  
Sbjct: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH--HASTVQ 3828

Query: 5680 ESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 5736
             +L+   Q   L  S     ED   +  +  L  +   L  + + LQ   ++    +Q  
Sbjct: 3829 MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRM 3888

Query: 5737 VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIA 5796
                   E E+K +++ +      +  K +   + +E    +   E + + I+  ++ IA
Sbjct: 3889 ADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENIRPMKKTIA 3945

Query: 5797 SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5856
             + S    L +       L        L +  + L+            V+  T      +
Sbjct: 3946 EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEI 4005

Query: 5857 --LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAA 5912
              L  +      + +   +S   A + P      +    Q ++  Q        L+    
Sbjct: 4006 ENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVL 4065

Query: 5913 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 5972
             +H      QE  E    P+ T++ G +       +   SE++     ++      ++ +
Sbjct: 4066 NLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEV 4119

Query: 5973 QSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAE 6026
            +  S K +  + K   SP+   S    +  M E +A      ++Q+   +I+   +S+A+
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179

Query: 6027 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--Q 6083
             L  +S   +   + +L+   T   E  +T  ++A        +  L  ++E+ R E  +
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236

Query: 6084 ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL 6143
             L   + +  EL+ WL      ++           +E QL+ CQ ML EIE KV  L E 
Sbjct: 4237 VLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLET 4296

Query: 6144 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6203
                ++  L     T+ EAE L+ KL+ +K +L ++Q  L +K    Q     K+ S+ +
Sbjct: 4297 C---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPE 4353

Query: 6204 LTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
                  P     L    T   Q  RQ   QQQ+ LE +  EQK  ++ +    +++  Q+
Sbjct: 4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQY 4413

Query: 6263 SAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQE 6320
               +  T+ ++       S E  +     S + Q   KW+ LH E S+K KL    L + 
Sbjct: 4414 CQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEP 4473

Query: 6321 QEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHL 6379
            Q     S    +L  V +Y    PT ++    T+ L+ L Q    + +Q    +   I+L
Sbjct: 4474 Q----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINL 4529

Query: 6380 EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL 6439
            ++KL++     S  L  VEE L +   L  E+      + E LA ++K++   +   K  
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588

Query: 6440 FSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 6499
              +A    G+N +++ +    L   L    +    R   +K  L    ++QN++K L+  
Sbjct: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648

Query: 6500 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 6559
            L  +K  + Q L  +  Q VAEQ++        L+  ++ + +L+  G++L +    +QE
Sbjct: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708

Query: 6560 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 6619
            + KL+D+ D +  ++ +R + L+     +SQ +  LQ + +L++ G+EK+A        S
Sbjct: 4709 VYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKS 4768

Query: 6620 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6679
            K  +Q  ++ HK +FQ L + M+L +    KI+   +Q    F  E + +   + +++ +
Sbjct: 4769 KVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQ 4828

Query: 6680 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6739
             G++L+ +L+ W   DE+   L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++
Sbjct: 4829 CGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888

Query: 6740 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR 6799
                 +LYQ L++GK+L+ S+SC +LE Q+ +L E WLS   K+  ELHRL+ +LKH   
Sbjct: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS 4948

Query: 6800 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 6859
            Y  +S  L  WL+S++  L +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V
Sbjct: 4949 YNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAV 5008

Query: 6860 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 6919
            +S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E+
Sbjct: 5009 ISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068

Query: 6920 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6979
            +SW++ +E+    DED++ +      +   LQK+K F+++++ KQ  VDFVNQS+LQ+S+
Sbjct: 5069 ISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLST 5127

Query: 6980 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 7039
             DVESKR ++T+FAE LG MN+ W  + G++  KIQ LE LLES +E EN +Q L  W E
Sbjct: 5128 CDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLE 5187

Query: 7040 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 7099
             QE+RLK   +     SVQ  L DCQD+E+ +  K K +++++Q+ L L ++    +   
Sbjct: 5188 AQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLED 5246

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 7159
              S + EL Q  +++   V QLK  ++SVL +W  +   +D++N   +   Y +   + +
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306

Query: 7160 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 7219
              SLE ++ QV+NLQ+LQD+ E  E S +K   +  +L   C P V E +    +  + R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKR 5365

Query: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 7279
            W  + + IA+QLQ +++LLQLW+ Y +   + A+ ++QQE +  +L   + + +   + +
Sbjct: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425

Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
               +QD  +L   +   K++      + ++L Q  ++S    +     SL Q    LE+ 
Sbjct: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKM 5484

Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7399
            L  +    +  +  ++ F   LE+L+  I+  EE L   D  H  +    +E  +     
Sbjct: 5485 LLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNH 5537

Query: 7400 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7459
            +L  ++ +PD++ LNE+  +LPL+D  +K +QN+NR W   ++   ER S+LQ   L ++
Sbjct: 5538 VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NE 5596

Query: 7460 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 7519
             FL  CE W++ L + E+ L V+++ +   LLEQQ+ +++ +AE+   Q I  S +    
Sbjct: 5597 KFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSL 5656

Query: 7520 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 7579
            +LL+  ++++R EF  + + L+++WQ  ++  +QR+G +D  +RQWQ +    E L ++L
Sbjct: 5657 QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFL 5716

Query: 7580 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7639
             + S+L  +  G     L Q R+L  E++ KE  F R++ +  LT+EAG++LLL+ D   
Sbjct: 5717 TDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKT 5776

Query: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699
            + ++   ++++Q+ WK    +L E  K+    ++ W++CEK I +   +L+  K +    
Sbjct: 5777 KESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP 5836

Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
            LP+ HE+LH E+   KELE ++ SWT +L +L  +K  L+ ++  +D+ +L E++E L R
Sbjct: 5837 LPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHR 5896

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            QWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q  DI IEEMIEKL+
Sbjct: 5897 QWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ 5956

Query: 7820 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 7879
            KD  EEI +  ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKK
Sbjct: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKK 6016

Query: 7880 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 7939
            LKET   +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+H
Sbjct: 6017 LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQH 6076

Query: 7940 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 7999
            S GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWR
Sbjct: 6077 SAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWR 6136

Query: 8000 LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 8059
            LWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELI
Sbjct: 6137 LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELI 6196

Query: 8060 NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 8119
            NKQYRRLARENRTD+A  LKQMVHEGNQRWDNLQ+RVT++LRRL+HF  QREEFE  R+S
Sbjct: 6197 NKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRES 6256

Query: 8120 ILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
            ILVWLTEMDLQLTN+EHFSE D   K++QL  FQQEI+LN NKI+Q+I  GEQLI+KSEP
Sbjct: 6257 ILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEP 6316

Query: 8180 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDL 8238
            LDA +IE+EL+EL RYCQEVFGRV R+H++L    P  +DE + S+ E ++ED   +   
Sbjct: 6317 LDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTD 6376

Query: 8239 HWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESA 8298
             W  R      S +PSS  SL        ERSG +TP SVDSIPLEWDH  D+       
Sbjct: 6377 SWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVGGS---- 6428

Query: 8299 MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRS 8358
                  S  EE ++   +       +S  HS     +       +    Q++   N+   
Sbjct: 6429 ------SSHEEDEEGPYYSALSGKSISDGHS---WHVPDSPSCPEHHYKQMEGDRNV--- 6476

Query: 8359 KTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8415
              P  P   T YK   G + L        +  + L    ++E+  L G         Q +
Sbjct: 6477 -PPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------QQS 6529

Query: 8416 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8475
            G  DRWE++QAQ L  +L++KQNL   QQ NSD+++I  WL  TE ELE L+  +  +DI
Sbjct: 6530 GAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKPPSDI 6586

Query: 8476 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
            Q IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W+   
Sbjct: 6587 QEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQ 6646

Query: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
              ++ WRG L+ +LMQCQ FH++S  LLL L +   R+ +    D   D   L +  ++L
Sbjct: 6647 GAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRREL 6706

Query: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
            MQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI  +LK L ++VS     
Sbjct: 6707 MQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS----- 6761

Query: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
             + L+ +  +Q   S   S DE+D SG   P +    P R K  R               
Sbjct: 6762 -QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA-------------- 6804

Query: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8775
              R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC 
Sbjct: 6805 -VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCT 6863

Query: 8776 LSNNFARSFHPMLRYTNGPPP 8796
             +NNFARSF+PMLRYTNGPPP
Sbjct: 6864 QANNFARSFYPMLRYTNGPPP 6884



 Score =  608 bits (1569), Expect = e-173
 Identities = 1245/6222 (20%), Positives = 2449/6222 (39%), Gaps = 953/6222 (15%)

Query: 21   LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
            LQ EQE  QK+ FT WINS LA+   P V+ DLF D+K G  LL LLEVLSGQ+LP ++G
Sbjct: 25   LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84

Query: 81   RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
                +     NI  AL FL  R IKL+NI+ TDI DG PSI+LGL+WTIIL+F IE+L  
Sbjct: 85   SNTFQCRI--NIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHFHIEKLAQ 142

Query: 141  NLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYTAGKQTGI 198
             L        S   V  + SS   SPP+K+  KV  + Q +A+KALL W Q        +
Sbjct: 143  TL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQCATYESV 201

Query: 199  EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
             V DF  SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL IPRLL+P
Sbjct: 202  NVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKIPRLLEP 261

Query: 259  EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
            EDVDV  PDEKSIMTYVAQFL++  D      + Q   +   G+ +              
Sbjct: 262  EDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK----------- 310

Query: 319  IFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKL 378
              ++++  ++  E D             KY S   F   +  ++K    ++       +L
Sbjct: 311  --EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDEL 359

Query: 379  SLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEET 438
              D   ++++WD +  ++  W I+L+ +LP PL    AWL   E  + E+++  Q H + 
Sbjct: 360  DKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQA 419

Query: 439  ANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFHFVSSTSE 497
               IQ K+   K L+   + H       +  +  N +P VPP++LE+M  R + +    +
Sbjct: 420  VTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRINNI--LEK 476

Query: 498  LHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYE 557
              ++ +EF   K  +L L+   +SKL  W IKYG RESVE LL+++  FIE  +F  + +
Sbjct: 477  KFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLD 536

Query: 558  VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDR 617
             ++Q   +  E+Y    G  +        +      +R     + +V+S L++V++ W  
Sbjct: 537  TSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQKVLACWAT 590

Query: 618  YGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSR 677
            Y   +  L+A  E+ +K     E  K+  F  L  W  +H  +N+AGNFL+E  +++V  
Sbjct: 591  YVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGS 645

Query: 678  DLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEV 737
             + ++L  LN RWR+L  + +                                    LE 
Sbjct: 646  SISKELRRLNKRWRKLVSKTQ------------------------------------LE- 668

Query: 738  SFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFATMSKLKEQ 795
              MN+ L+I+     +Q  P  D    I++K      + S     E  E +    K  E+
Sbjct: 669  --MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEK 721

Query: 796  LTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFK 852
              K  E ++  L    + ++L+  +E  E +  S  D     +++ T +E   +      
Sbjct: 722  HEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESLKHLIAKG 777

Query: 853  QKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMV 912
                EL+A  E+      +++   Q++    +  +VL    Q ++Q     + +   ++V
Sbjct: 778  SMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQI---NVV 828

Query: 913  KKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQL 970
            K     K    V  +  +  K EES+ ELE  +  AQ+ L ++  P EL+ +H E     
Sbjct: 829  KLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIIS 888

Query: 971  DQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNR 1030
            + + L  +LKA +EL + + E  +  L+E  R +  +W+ L  E   ++  LKID+EK +
Sbjct: 889  NTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGK 948

Query: 1031 FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPV 1090
               ++ +   ++++E KL+ +  ++ +IKEH   FS++G  +     ++++ ELC +LP 
Sbjct: 949  LSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS 1008

Query: 1091 RDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGI 1150
            +   ++        LK+    I+   +   E     +      S+    I+T+E +    
Sbjct: 1009 QKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP 1064

Query: 1151 KGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELA 1208
              EA    + N    ++A+E           T+ +  S   VL  +  E+  +K  D  A
Sbjct: 1065 HSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIMEK--DYSA 1110

Query: 1209 KLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVKNSLE--- 1246
             ++S  +   T    +E  L N                  C+Q K    +++KN  +   
Sbjct: 1111 SINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARW 1170

Query: 1247 ---ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQLLLHHQQK 1281
               E+IS                      KE + + +  L+T  E+L  A +L+L  ++ 
Sbjct: 1171 KEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKA 1230

Query: 1282 TKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRK 1341
            +  +      + +   Q         DR ++ LR ++ ++        R E      L++
Sbjct: 1231 SLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288

Query: 1342 WERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
               F+ +  +  +++Y  Q  G +H    S  +L++L   L   +      E +   + +
Sbjct: 1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSAS 1348

Query: 1399 LVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEEDIKTMEMV 1444
              + A E  L  +NK+    L++ +AK + + +K L          +DT  E++     +
Sbjct: 1349 DTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSI 1408

Query: 1445 KTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV---TIQEI 1493
            K    H +G   E      TE+ K L       N L  +   +  QIS+I +   T+  +
Sbjct: 1409 KLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAV 1463

Query: 1494 ESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREH 1539
            + +  S++               L+E A S   F    E    +     +  +       
Sbjct: 1464 KHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALV 1523

Query: 1540 AQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATETYKVLQE 1594
             +CLE  G +L  L Q Q F+  L  +   ++SV   +        +     E   V +E
Sbjct: 1524 TECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEE 1583

Query: 1595 HMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652
              +  + ++ ++       F  +  K        +EA  +  ++ DI  + ++    L  
Sbjct: 1584 FNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGR 1643

Query: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
             LA W +L    +    W E+   K    ++    DR +++ ELQ+ +   +E   + + 
Sbjct: 1644 ALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSEFSRRVAE 1702

Query: 1713 YSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLPQIINKRI 1757
               LLQ  E    +   +   + K+ H+++                E   DL Q    +I
Sbjct: 1703 IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQ-AKTQI 1761

Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--------LTRHKDH 1809
               +S++      D L + F+   ++    LQ    + ++++Q+         L +  + 
Sbjct: 1762 GMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYES 1820

Query: 1810 AAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQVVERRQLA 1866
             +++ + K  +  LQ H +KL         D    ++   ++CF+  E    V ++ Q  
Sbjct: 1821 VSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKL 1878

Query: 1867 LSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES--DLIEKDL 1909
               L                + ++ H   + +   +   V     + K ES      K+L
Sbjct: 1879 SDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKEL 1938

Query: 1910 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1969
             D+LQ    L+    +L   L+  +   K G  E           L  + E+ +++    
Sbjct: 1939 EDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQFESVAQLN 1997

Query: 1970 QS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPTR------ 2011
             S       E + + +      D+ + LL+ + +IEE      T+ +   +         
Sbjct: 1998 NSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI 2057

Query: 2012 QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAPEVDREIN 2061
            + +++ L V N  E ++   E      E+  LK +        + Q + + AP V + + 
Sbjct: 2058 KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLT 2117

Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDL 2121
             +   WD+T  L              +   + L     K L++   + +    +K +++ 
Sbjct: 2118 DISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEA 2167

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTV--DKWL 2179
             +A  +H   + K   + K    F  K + L S LK++ S    L++     +   + WL
Sbjct: 2168 GFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWL 2224

Query: 2180 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKE 2239
            ++ + L E++                           + Q+ +++ NLD H+R       
Sbjct: 2225 EI-KHLHESL---------------------------LQQLQDSVQNLDGHVR------- 2249

Query: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTL 2299
               E  +  + + +L++ +++  +   +    P  Q    + +QKL+  +    +  GTL
Sbjct: 2250 ---EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTL 2306

Query: 2300 KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISST 2359
            K   A +  V++  + +     K +   + C Q          KD++  L S +  +   
Sbjct: 2307 KKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASAKQEMECC 2356

Query: 2360 QENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHFSESMQEF 2418
               LNS+ +   S E +      T   ++ +A S +   TQ S   E LE+ +  +    
Sbjct: 2357 ---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSA 2410

Query: 2419 QEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAVTQEGQTL 2473
             E  +  + +  A+ES   T D    E K+++LQN    LD++   +       +E + L
Sbjct: 2411 VEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ-----LEEIEKL 2461

Query: 2474 YAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLW 2530
            Y  L  +   I    Q +     E     L       Q L +    L + +         
Sbjct: 2462 YTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV 2521

Query: 2531 IHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESLDKLSQRG 2581
            + + +E       + + L   K+ +     +    + K++ F+  +   ++SL  L  + 
Sbjct: 2522 LRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKW 2581

Query: 2582 QLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQ--- 2634
            + LS   H    + +L      QL    + + +  ++K     V   E   L   +Q   
Sbjct: 2582 ENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTE 2639

Query: 2635 -SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNMAIGKGEQ 2690
             S+    + +Q RL   E   G++  +       +      ++KG+ E+++    G+ E 
Sbjct: 2640 ISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKE- 2698

Query: 2691 ALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSSVHAQSTL 2728
              + + ++G   ++ Q ETL+                       +WA  +   ++    L
Sbjct: 2699 --KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPL 2756

Query: 2729 --ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2779
              + ++SQ        +  + R+  +E   E V  K+     P     E   L + L+ +
Sbjct: 2757 LPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDLNNTLEDL 2811

Query: 2780 LSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKEKMRKVEE 2837
             ++   +   + +   +S++L  K E+ S  F    + +L  Q ++ + + + +    E 
Sbjct: 2812 RNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEA 2868

Query: 2838 IVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASR 2896
             +K H + L+A  +    + S     L   +++  + +  ++    +++ + + +I  +R
Sbjct: 2869 ELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKNLKIRTNR 2926

Query: 2897 LSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
            + R +++   EV+       C   H +  AL+ +     DS+ + +  L   V++    E
Sbjct: 2927 IQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEVNKGVKEE 2980

Query: 2956 QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQ-KAEP 3014
                  +  L+  L      +      L +L+ K   + I   W   Q  LD LQ +   
Sbjct: 2981 ------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQLQTQVFE 3026

Query: 3015 RTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFR 3074
            + ++L+ ++ +L  F  +     GK   L+ +   + LQ  K    +  +         R
Sbjct: 3027 KEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAPDSSPESR 3080

Query: 3075 DFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNMMLSKGEL 3130
                 +++ +I  AKC   +I + ++E  T     K +E L    N +    +      +
Sbjct: 3081 RLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNM 3140

Query: 3131 LSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVSAEPIQD- 3187
            +  L  KE   K  Q K+  +        S L Q    L NL+I+ +++ + + E  Q+ 
Sbjct: 3141 VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDNCEAFQEQ 3198

Query: 3188 -W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI---------HCYEPQ 3229
             W        ++  EK   E+S+   D+  K RE + LQ  L              YE  
Sbjct: 3199 VWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYE-N 3257

Query: 3230 LNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLALSNLTKEK 3271
            L R KE   +  E   + ++                     +  +L S    + +LT EK
Sbjct: 3258 LTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQDLT-EK 3316

Query: 3272 VS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPTSDKSVLD 3317
            +               L  +V++++      K  +   T+A   L++Y C+   ++ +  
Sbjct: 3317 LGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRKMEEDIYT 3373

Query: 3318 S------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV----------LQNTS 3352
            +             +L L   EAL  ++Q K +   +I T+ E +          L+ T 
Sbjct: 3374 NLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTE 3433

Query: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
             +GI  + + + ++ + W SLL A    +   E    +W    + + + +  +D+++  L
Sbjct: 3434 NDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEEL 3492

Query: 3413 NE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVKGAGMTE- 3458
             E        +  + +EL D     G    K +LL   +L     ++ + E  GA  T  
Sbjct: 3493 PEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVP 3552

Query: 3459 --HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQ 3510
                +T ++      LQ +Q+    +Q   +E  + +++++ L   +Q+   +F+    Q
Sbjct: 3553 AFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQ 3612

Query: 3511 EQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
            +  EK +Q+  L+      + T  ++ E L++  +E   ++ + + ++ +     +   +
Sbjct: 3613 DHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672

Query: 3569 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQ 3628
            ++    + +   +Y                    M +K ++++  L   E+ +     +Q
Sbjct: 3673 EKISNEVLKSSPSY-------------------AMRRKIEEINNGLHNVEKML-----QQ 3708

Query: 3629 SNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQ 3687
             ++  ++ Q  Q K W +E+  +  ++ E+ +  Q+I+++    ++       +   +YQ
Sbjct: 3709 KSKNIEKAQEIQKKMW-DELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQ 3767

Query: 3688 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3747
             +  +   +   L +    +EE    L S   W  +T     N A   D + T  +    
Sbjct: 3768 QVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHA 3824

Query: 3748 KTLEVLLKDMEKGHSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRK 3806
             T+++ L+D E+ H+LL S   +  + ++ +    E + L + I +   Q+  L   + +
Sbjct: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIME 3880

Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSL 3862
                +++          + K++ + +++ + IL   E     P+  L   +  L   + +
Sbjct: 3881 SLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPM 3940

Query: 3863 QQT---VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEA 3919
            ++T   ++S++  ++ + + G   L + Q      + +QL  D + L ++ +E    L+ 
Sbjct: 3941 KKTIAEIVSYQVELR-LPQTGMKPLPVFQ------RTNQLLQDIKLLENVTQEQNELLKV 3993

Query: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME-EIAGFED 3978
             +K   +++ E++ +++ L   S +          SLE ++   A     ++ EI   E 
Sbjct: 3994 VIKQTNEWDEEIENLKQILNNYSAQF---------SLEHMSPDQADKLPQLQGEIERMEK 4044

Query: 3979 RLNNL-QMKGDTLIGQCADHLQAKLKQNVHAHLQG-----TKDSYSAICS----TAQRMY 4028
            ++ +L Q K D L+   A  L      N+H HL+       +D   A+ S     A+R  
Sbjct: 4045 QILSLNQRKEDLLVDLKATVL------NLHQHLKQEQEGVERDRLPAVTSEEGGVAER-- 4096

Query: 4029 QSLEHELQKHVSR------QDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL 4082
             + E +L +  S       ++ +++            EPSPQ   S  +  K ++  RA 
Sbjct: 4097 DASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRAS 4156

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL------------VQAQNL-- 4128
                    +    +    N+  +    D   TEQ  E  L            ++A  L  
Sbjct: 4157 SSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDS 4216

Query: 4129 --TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELEL-----NIAQNMVSQVKDFVKK 4181
               QG  E +  K+       +  + L   K + +ELEL     N+A    +   D  + 
Sbjct: 4217 SDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQV 4271

Query: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRD 4241
            L+ +      ++ ++          EHK +  L +   D     N       E L     
Sbjct: 4272 LEQQLVGCQAMLTEI----------EHK-VAFLLETCKDQGLGDNGATQHEAEALSLKLK 4320

Query: 4242 YHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA-----LQERKYAIEDL 4295
               C +  V++ L++  +E  +       S   H EAL+ + L+     + ER       
Sbjct: 4321 TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK 4380

Query: 4296 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL----EDLIKRKIQVSVTNLEELNVVQS 4351
              Q+Q+++E   ++ K+ +K    + ++ W Q      D  +     +  +  E +V  S
Sbjct: 4381 DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS 4440

Query: 4352 ----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQNL--------------------- 4383
                + Q   +W     E    I   L Q   P ++ N+                     
Sbjct: 4441 ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT 4500

Query: 4384 ----LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSD 4439
                L D     S L+ ++ + +    + D+ + +L L   Q +       +       D
Sbjct: 4501 YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED 4560

Query: 4440 LVGQRRKY---------LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVS 4490
              GQ+  Y         L  ALS+K   L+       +      +      +CL     +
Sbjct: 4561 GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA 4620

Query: 4491 KQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEVT--EQEKSEVLGK--LQELQ--S 4541
               ++ KS +A L   ++YQNE+  L+ Q   L+K  T  +Q  +E+ G+   ++LQ   
Sbjct: 4621 AVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSKTSLQQSLNEISGQSVAEQLQKAD 4676

Query: 4542 VYDSVLQKCSHRLQELEKN---------LVSRKHFKED-FDKACHWLK------------ 4579
             Y   L+    R+ +L            L+   +  ED  D     L+            
Sbjct: 4677 AYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVT 4736

Query: 4580 --QADIVTFPEINLMNESSE--LHTQLAKYQNILEQSPEYENL----------LLTLQRT 4625
              Q D +    + L+    E   H  L + ++ +    + EN           +L +Q  
Sbjct: 4737 ESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAY 4796

Query: 4626 GQTILPSLNEVDHSYLSEK------LNALPRQFNVIVALAKDKFYKVQEAILARKEYASL 4679
               ILPSL +   ++ +E+      L    RQ  + +     K+ +  E   + ++   +
Sbjct: 4797 SAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEI 4856

Query: 4680 IELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEG 4739
            +  T  S+S +E    R+        VE     Q   R I  + A L +    LN+ K+ 
Sbjct: 4857 LISTLPSVSLVEETEERL--------VERISFYQQIKRNIGGKHARLYQT---LNEGKQL 4905

Query: 4740 FRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
              S   P    ++  L   +  L ++ +  +  L+        + +   QL + L+S + 
Sbjct: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQH 4965

Query: 4800 EQSKVNEETLPAEEKLKMYHSLAGSL------QDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              +   E++L   + L    S   +        D    LK   I + +   HL       
Sbjct: 4966 TLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTAT 5025

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELS--GPV 4911
             R  +  ++ +  +L + + +   +     ++ +  +  ++  + W+  V+ + S    V
Sbjct: 5026 LRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSV 5085

Query: 4912 YLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFT---KAKELISADLEHSLA 4968
            +   +   ++  ++K +  + E+     I++ ++    +  T   ++K     +    L 
Sbjct: 5086 HSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLG 5145

Query: 4969 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESA 5028
            E++     +   L  +   L ++           Q  N+WLE  +E L+       V S 
Sbjct: 5146 EMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205

Query: 5029 EENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTGK--EDLEQKVASLELRS 5082
            ++ L    +  +        L+EL     TL+    PL++ T    ++L QK +S+  + 
Sbjct: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQV 5265

Query: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
             ++          +Q    +W  Y +  +EV  +M        E S     S      ++
Sbjct: 5266 NQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTIRFWYCMEHSKPVVLSLETLRCQV 5317

Query: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5202
               ++L     S       L+E   +L+      ++    +   T  +RWT++     DQ
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNT-HKRWTQVNQAIADQ 5376

Query: 5203 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5262
             +  +  +  W  ++N   +A   + Q + K    +    S   L  +L      + EL+
Sbjct: 5377 LQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQ 5436

Query: 5263 QQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQEL 5322
                       Q  S+L     P P E    M     +    L+  ++     K++  + 
Sbjct: 5437 HDVQKTKEAFLQNSSVLD--RLPQPAESSTHM-----LLPGPLHSLQRAAYLEKMLLVKA 5489

Query: 5323 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK 5382
             + E V +Q                    +   +LE L+ L+     +   + +  +E  
Sbjct: 5490 NEFEFVLSQFK------------------DFGVRLESLKGLIMHEEENLDRLHQQEKENP 5531

Query: 5383 EKYLGLYTILPSELS--LQLAEVALDLKIRD----QIQDKIKEVEQSKATSQELSRQIQ- 5435
            + +L     L ++      L EV+L L + D     +Q+  ++  ++ AT+ E   ++Q 
Sbjct: 5532 DSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQG 5591

Query: 5436 ------------KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
                        K  + L  I   LK    N +    +Q+           K++E + ++
Sbjct: 5592 IGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQK--------TYKMLEAEVSI 5643

Query: 5484 QK-----FLEQNGQL-------GKP-LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5530
             +     ++ Q+ QL        +P    +  KLT+  Q  ++    R   ++      +
Sbjct: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQ 5703

Query: 5531 EYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQT--LLEE--SKEIDSELEAM 5586
            ++   +E + +++     L        SA + +E++ L+QT  L+ E  +KEI  +    
Sbjct: 5704 DFTTSVENLFRFLTDTSHLL-------SAVKGQERFSLYQTRSLIHELKNKEIHFQRRRT 5756

Query: 5587 T--------EKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
            T        EKL   T +   E + +++++L    +++   +   ++  Q   +   + E
Sbjct: 5757 TCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCE 5816

Query: 5639 AELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEME 5680
             ++K+L++ L+  +A    P      L E L + + L+ E+E
Sbjct: 5817 KKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKELIKELE 5855



 Score =  117 bits (292), Expect = 7e-25
 Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)

Query: 1237 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1296
            Y+  +K    +LI     +Q+   +I        + Q +    QK    + +  + + ++
Sbjct: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689

Query: 1297 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1351
            A+ + +GE   LP    +E+ KLE  LD   G+ R+R  +     VT  + +        
Sbjct: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749

Query: 1352 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1409
            +V+ + +   +H       S  +L +++E  K F ++   + + +QA +    A  +P  
Sbjct: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
             QN++    +  +   +VK LE+   +    ++ +  KW+ F  N+ +L       EK+L
Sbjct: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854

Query: 1470 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1529
              L ++  ++ +        ++E E +L        E  SF Q +      +  A+L Q 
Sbjct: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898

Query: 1530 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1577
               G++L     C  LEG I       LS  +K +  L ++Q       S +   D+L  
Sbjct: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958

Query: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
             ++        +K  ++ +++ Q L+++ S I  F   +++V  + S      ++  Q  
Sbjct: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014

Query: 1638 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1697
              L   KE  TA   L A   + E++ +  +T L   + K    +M+    R  +   + 
Sbjct: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070

Query: 1698 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1730
             +  ++++   + S +S         LLQ                  + +SL  +++ D 
Sbjct: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130

Query: 1731 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
                 +      HL +++ +W  +  ++N++I  L+ ++    + +  +   + W++   
Sbjct: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190

Query: 1786 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
              L+T  +  S++  Q  L   +D   ++  K   L  L+     L S      + LL+ 
Sbjct: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246

Query: 1845 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1903
             A    +LF++ S V+ +     + +   LQ       +  ++   T+     M  ++  
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306

Query: 1904 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1950
            ++  + L   ++N ++L+  A S +G   K Q  +             I    Q T  R 
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366

Query: 1951 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1991
            T     +  ++++ Q+LL                 KQ EA    LA +  +  +  E L 
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426

Query: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2047
             +++DI+E    +   + T++A  Q   V ++L     S  H L         +A  + +
Sbjct: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483

Query: 2048 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2103
              +  A E +  +++ +   V  +  K LI HE +       +L R +Q  K      L 
Sbjct: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536

Query: 2104 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2163
            +  ++      I+   ++       + A   +    +     T+      SEL+ I  ++
Sbjct: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596

Query: 2164 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2223
              L         +KW+ + EK+EE    L+V ++                 N +P++ E 
Sbjct: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630

Query: 2224 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2283
                      ++  K  E+EV       +   ++   L + T+ +E  P+     + L  
Sbjct: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679

Query: 2284 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2336
            + ++A +     KG +       +DFT     + +F+ D +         L++  + +  
Sbjct: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731

Query: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396
             +L + + +  EL++++ +     +   + C     A  + L   +T  +K  E+V +  
Sbjct: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784

Query: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2448
            S+ Q S ++ +E   +E +++FQ          K+  +     +VL+A+       LH D
Sbjct: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843

Query: 2449 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2501
            L N  + + + +  L + TQ   E QT+ A L++ +    V  ++EQI   + +++    
Sbjct: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903

Query: 2502 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2560
            +    KQ ++D  +    F +++++L  W+ +ME +   T ++   +     +K+ + ++
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963

Query: 2561 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2620
             +F    L  ++  D+L +     S +   A  + +L +++    Q+L  +   +++  +
Sbjct: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018

Query: 2621 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2679
                  + L++ + ++  W+  I+  L+      +     ++KRL++ QD+     +   
Sbjct: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078

Query: 2680 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2735
             +       +  L  S    N+     IQ    +L   W +I + S+  +  +E     W
Sbjct: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138

Query: 2736 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
              +++  ++ E W++S ++    P   +       VL    +  L   E   R +H  + 
Sbjct: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191

Query: 2796 K---SRELYEKTEDESFKDTA 2813
            +     + Y +   E+  DTA
Sbjct: 6192 QLELINKQYRRLARENRTDTA 6212



 Score =  105 bits (262), Expect = 2e-21
 Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)

Query: 1211 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1266
            +   K   T L ++ +  SN        E    +L+    EL     +     E++L+  
Sbjct: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554

Query: 1267 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1321
             L+  +     +H++    + K++     D +  + +A    G   +   E    L+  L
Sbjct: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1381
            +  + +   + + ++  L     ++   + +   L ++ +S ++ L+  S +S++ +L++
Sbjct: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674

Query: 1382 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1441
               ++   E+   +   L  E   + L             ++ ++V KLED L+      
Sbjct: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720

Query: 1442 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1487
             M++ ++    S F T S            V I +++     L+ + S  A+  QI   K
Sbjct: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780

Query: 1488 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1547
            V  Q++   ++ ++ ++  +      +          ++T+++   E+ R+    L+   
Sbjct: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836

Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1603
               L + ++F+EN   +++ +    + L   +   S   ET + L E +   Q ++    
Sbjct: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889

Query: 1604 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1660
               + +       +++V   SC +   + A L++Q+  + ++       L+ LL H    
Sbjct: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949

Query: 1661 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1717
             ++      WLE  +   +      +++S D   +   +        EV  ++S  + ++
Sbjct: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009

Query: 1718 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1773
             +   L  +  + D   ++  L Q +++W      LP I  K        +   +   E+
Sbjct: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068

Query: 1774 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1827
            +     W+     E QT+ E S+     A      L +HK+   E++ K+  +  +   L
Sbjct: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
             +L +                     +  S+  ER + A  HL E  +    + G+L + 
Sbjct: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161

Query: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
             Q +E                    L++    E+    L+  L   +  LK   + Q+  
Sbjct: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200

Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
               +  +L  + + I+N L  K     AL  LK+++   +   +  +ED   R D+   K
Sbjct: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257

Query: 2008 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2056
                       + + Q++ Q  ++++QL DE+N       +  + +K +         +V
Sbjct: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317

Query: 2057 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2102
            +       E    E +W+  + +I + +G C  + +++ E        +  +  A++  L
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377

Query: 2103 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2162
            + A S++       +      A  K + AK +       L N +  G +L +E+      
Sbjct: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
            D   ++ D++ T + +L  S  L    DRL                 E  ++  +P    
Sbjct: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473

Query: 2223 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2273
            ++     +L    L+K  EFE   S+ K+  +RLE L   +     +L  L +  +  PD
Sbjct: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532

Query: 2274 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
              L  + A   Q   +EH  E++   K  L D   ++ Q     N    W      +L  
Sbjct: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585

Query: 2330 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2378
            C++      NE     CE  K ++ ++K  ++ + +++++   L    + Y   E E S+
Sbjct: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643

Query: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2438
             + +           QL   T+   +      FS+    +Q    G +        R GD
Sbjct: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694

Query: 2439 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2488
               L  +  D    ++N+   ++D    L AV  QE  +LY      H  K      Q +
Sbjct: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754

Query: 2489 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2545
             T      +A  K  L  D +  +     +   +D  + +   + EM ++F +  E   +
Sbjct: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814

Query: 2546 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2605
             ++ I E K+ +  ++    + L   E  + L    +L+ E         +   +L T  
Sbjct: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872

Query: 2606 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2639
             +L R        + KE++            +VA+++ E            E  + +  W
Sbjct: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932

Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2699
            +  +++++    + +  ++ +EK      + + +  E +++L      G+Q +++SNK  
Sbjct: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988

Query: 2700 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
               I  +L  + + W    D++ S V       + I Q +   +  + L  W+  ++ ++
Sbjct: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045

Query: 2757 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2808
              P+        + Q  L E+  L   ++   +  E        L+  S     +TE +S
Sbjct: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105

Query: 2809 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2868
             + T +  L  ++ +I  ++ E+  K+EE  +    +LD    F DWL SA+      + 
Sbjct: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164

Query: 2869 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2928
                 ++ +++L + +     R+I   RL+++E +  + ++    +  +      Q +  
Sbjct: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221

Query: 2929 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2987
              ++W++        L+  V+ +    + F+ Q  + E   E     L     QLT +E 
Sbjct: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273

Query: 2988 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3030
                + D+++ +     QEI                 +QK+EP    L + +L EL R+ 
Sbjct: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333

Query: 3031 RDL 3033
            +++
Sbjct: 6334 QEV 6336



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)

Query: 481  QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 527
            +L D  ER H   +  +  + K+E         L  +Y  LS   + ES+  + +     
Sbjct: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749

Query: 528  -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 585
             +K G+ +     L+   S +      E ++V +Q  K  A+M +    S +   ++++ 
Sbjct: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807

Query: 586  ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 629
               F  E   + + L  + R     L+ ++  W+ +    ASL+             + +
Sbjct: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867

Query: 630  EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 685
            E+ E+ L +  +  +   RN+     + +  +N+    +   +C E+  +   L++Q L 
Sbjct: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927

Query: 686  LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 738
            LN        R + L   +  Y +  + D++ K       TL+ +  E    +S+ L+  
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984

Query: 739  FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 798
              N+    +  ++++++  +  A   I  +  HL  KE+     +   A   +    L  
Sbjct: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042

Query: 799  VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 856
                    L++ Q   +P  +   +M S+ +++         +   + +S +    QKH+
Sbjct: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102

Query: 857  ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 916
            E    +        +++  +QS+ +  T     K +++T     + +++  +  +     
Sbjct: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159

Query: 917  DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 975
               +H+E     + + E     L   L   +E L+    PE ++          D +  L
Sbjct: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219

Query: 976  NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1006
                KA DEL                             + +L +  Q  L+ +++ + +
Sbjct: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277

Query: 1007 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1058
            +WK    L  E     +     +E ++  + S+E  R +++    L  +    EGS + +
Sbjct: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337

Query: 1059 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1118
            +E  V    KG   LC    ++IEE C                H    ++  AI    +K
Sbjct: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379

Query: 1119 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1174
                   WK Y++   E ++ +   E + + +   ++   N  E+     + ++E+++ V
Sbjct: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439

Query: 1175 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
             K  E     S +  RL    E S+          L + +   K L+   +E E +LS F
Sbjct: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499

Query: 1232 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1287
             D        K ++ +  E L    ++ +E  +  L+      AQ   + H  +   +  
Sbjct: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558

Query: 1288 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1343
               DV  +  Q    +             + +T   LER  E Q      +      KW 
Sbjct: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605

Query: 1344 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1403
                          Q     E  L      SL   LEQ K +        ++AE  + + 
Sbjct: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646

Query: 1404 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1452
                   Q+ QLL     +       +  KL D  +  ++ +   K        +W  F 
Sbjct: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706

Query: 1453 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1512
            ++ E L  ++T+    L+A++         + Q +  I E+++K    +  +    + A 
Sbjct: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760

Query: 1513 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1569
             +  GE   +   L     + R   +L++  + +E  +   + Q Q   E   + ++ + 
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820

Query: 1570 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1619
            E + +L V +K  S     E ++ L    +L + LE        +L    T  +   R V
Sbjct: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879

Query: 1620 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1677
            +  D  V  ++   L +Q+ED+  R   R+  +E+ L  W    ++      WL + E K
Sbjct: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939

Query: 1678 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1733
                  DIS +        ++I+ LQ + + + + +S    +L Q+ + L   ++K    
Sbjct: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990

Query: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
             +   L ++++RW+ L  +I  R+  L+   A  QQ D+ + +   W+    SEL     
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050

Query: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1846
              + D Q           E++ +  E Q LQ     H A + S+    D+ L    A   
Sbjct: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099

Query: 1847 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1891
            E      ++ ++ ++RR   +  ++               +FL  ++     L+   +T 
Sbjct: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159

Query: 1892 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1951
               NS     S+++     + L+  +A +         L       +  + E RT   + 
Sbjct: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214

Query: 1952 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2005
              Q+  E  +R  NL    Q    A+    + F +Q+EE   + E I     E       
Sbjct: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270

Query: 2006 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            ++  +      ++R  N  + E+  + +++  L    +Q+ QK
Sbjct: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313



 Score = 90.9 bits (224), Expect = 5e-17
 Identities = 420/2300 (18%), Positives = 883/2300 (38%), Gaps = 390/2300 (16%)

Query: 6582 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6637
            NQN+    ++E+  ++      TGQ K+A D + ++   E    E + +LD+        
Sbjct: 713  NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761

Query: 6638 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6694
                   +T   + +   + K + F  ELMA++  +L+   +        +++L T    
Sbjct: 762  ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814

Query: 6695 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6754
               + +   Q+ VV+       L + + D  +D     +  +  L  Y  +  Q+L   +
Sbjct: 815  KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872

Query: 6755 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6809
                  S  +L S+  +     +SNT  ++K L  +E +  + T       + +S D+  
Sbjct: 873  ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924

Query: 6810 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6869
              +S    L  + QQ + +  E   + D++   L+  K+++ +  L             +
Sbjct: 925  KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967

Query: 6870 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929
            ++  T  L  E     S+    L  +    E L +L  ++LPS+ +  EV     L+++ 
Sbjct: 968  RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022

Query: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
             QK E  +K +     IH  LQ   G     N   +T            +   +S     
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078

Query: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 7035
            T+ A +         +L+ L  E I        +  LLE +  Y        +NN   + 
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138

Query: 7036 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7095
            + F ++E R          + +Q  L D Q +++   A+ KE E I       + + K+ 
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190

Query: 7096 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
                   TL+E   +    L+  +  L+  L+ VL      K +     S L   + ++ 
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247

Query: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
             F L+    +A ++   +L+N+QD + KQ     +     N +LKE HP     + N + 
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302

Query: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
            +   ++  +   +     + KAL       +D+     +     E  T+    +A++  +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352

Query: 7275 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7331
            A +   T      +  L+K      D    + ++  +  ++  D S  + + +  + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412

Query: 7332 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7384
             H   +++   ++   L+A +       K+++ +++ I +    +  +DP+         
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468

Query: 7385 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7444
             L  + + ++E + +      MA  L    + G    +N ++ +    L  +   + ++ 
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526

Query: 7445 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7501
             E+  ++   L Q+Q F    ++ +  L+Q E+ + + +  +Y   ++L ++    E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581

Query: 7502 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7558
             E     ++   ++ +  + Q  L + +  +   F  +  ++ ++W  +  + +     +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641

Query: 7559 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7618
               +  W +   +   + +W  +             + L Q  T  D  + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691

Query: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7672
             +   +    +   L   S     LQ   + I  K +     L  +          A L 
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751

Query: 7673 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7728
            +D ++ +  I  +   L+      S  +    EE+  + ++ K     LEN +G  T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811

Query: 7729 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7788
            ++L    +++S         + N +  +LQ  + +L +          +  N+W  FS  
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854

Query: 7789 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7843
               L E     E+K S      +E+ ++KL      E    + +KI+     L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905

Query: 7844 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7900
             KA  +   S +   E++L K+         +  AR K+L+++L  + +L  +  +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958

Query: 7901 LAHIE------------------------------------------SELAKPIVYDSCN 7918
            L + E                                          +E  + I+  +C 
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018

Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978
             +  Q  L +  E++ + +   T   S  +L   ++H            +  +    L+ 
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078

Query: 7979 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
            R    + I  +  E   +IE   +        L QK L D S    W  +    + + S 
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136

Query: 8028 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 8070
                   G  Y  +KE       ELKK +    A Q  + E   QL++  K  ++     
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191

Query: 8071 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
              D    LK++  +GN             + W  ++    S+L++L+  +   +      
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251

Query: 8118 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8168
            DS  V +T+++  L N   E  S  D       V+ K+++L+  +  +SL    +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8211
              + + + +  +   II++++  L+                   C     + +R  +K  
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371

Query: 8212 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8268
            +  LP  E    SD +   ++SAA+  L   W + + DS +    S  LSL+  + +++ 
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430

Query: 8269 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8317
               R     + + PLE D             L   LE+  +   P E  E   + +    
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489

Query: 8318 LRGAVGLSGDH-SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 8376
            +   +G S  H   L   +  L K  +     ++  +  + +   +   L T  +     
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVG 2549

Query: 8377 LGECSSSIDSVKRLEHKLKEEEESLPGF------VNLHST-------ETQTAGVIDRWEL 8423
              +  + +D +K+    +++E++SL         ++ H T       E+Q   +   WE 
Sbjct: 2550 PLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQ 2609

Query: 8424 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 8483
            ++ Q   K     Q + ++ +F + +N +     DTE  L+Q Q+           LQ+ 
Sbjct: 2610 VEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ----------HLQL- 2651

Query: 8484 KLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKESRDLQDRLSQMNG 8529
            +LK  ++   ++  I L+ +L + +        QA+         KE ++L+D ++ +  
Sbjct: 2652 RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKK 2711

Query: 8530 RWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ 8589
            +W+     LE      ++ + +C   ++M    +L  +N+    N  +P+   L  +IL 
Sbjct: 2712 QWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSIPL---LPDDILS 2763

Query: 8590 DHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKEKVHVIGNRLKLL 8645
               K   ++ H+ +L  Q  V SL +        L   EG+D     E +    N+ ++L
Sbjct: 2764 QIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLR---NQYQML 2818

Query: 8646 LKEVSRHIKELEKLLDVSSS 8665
            + + ++  ++LE  L+  S+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSN 2838



 Score = 79.3 bits (194), Expect = 2e-13
 Identities = 565/3062 (18%), Positives = 1152/3062 (37%), Gaps = 460/3062 (15%)

Query: 5160 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
            V L E  +Q  K G    K           + +T    VA+D EK++   V+ W      
Sbjct: 706  VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755

Query: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5276
            V    ++   +++ L    A+ +   EL+   E  D   ++++    Q+S   +L     
Sbjct: 756  VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813

Query: 5277 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5334
            + +Q+           L+  +  + D    L+++ K++ + K ++  +   + +  Q  S
Sbjct: 814  AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873

Query: 5335 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393
                + + KE L  + T  +   L+ ++ L    T   ++I+   EE+       +  L 
Sbjct: 874  PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930

Query: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453
             ELSL + ++ +D++ + ++ D I ++E+     ++L R+ +   K L        ++  
Sbjct: 931  HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987

Query: 5454 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504
             + Q     +VL    EEL    S+      L + +  +++ L+   ++   L    G  
Sbjct: 988  CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046

Query: 5505 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5564
            T  ++ TI  +ENR    +  A   +  N+         EKA      T+ ++ AS LR 
Sbjct: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097

Query: 5565 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5621
              +  ++++E  K+  + + ++ E+      +   +      +  ++   E +     ++
Sbjct: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153

Query: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5678
             +L +LQ    +      E + +   LE     +  P V   R +LKE+    Q  L + 
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213

Query: 5679 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5729
            MESL+  ++ V         LC S L + +  +    L  A  R+ +    +Q +  +Q 
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272

Query: 5730 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5763
              CN                    MQ  +++Y+   + M H  Q  E   + +ED     
Sbjct: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332

Query: 5764 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5820
                ++   + +L A  ++  +E    +K  + +I  +  K K L    K   M     E
Sbjct: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392

Query: 5821 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5875
                      LD   +     H   V       + LL     ++ E     +   S+IS 
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452

Query: 5876 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5934
                + P     T  +V         L     + +  K H    A S   ++ G E +  
Sbjct: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506

Query: 5935 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5992
             +  +    WE  K +++E        LE  ++YQ+    ++T ++  E  + L  S   
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566

Query: 5993 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQ-------- 6040
              + + ++AE + + +E    L + D+IN++  +L   L   ++ E  P E+        
Sbjct: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626

Query: 6041 ------------------LALQSTLTVLAERMSTIRMKASGKRQL--LEEKLNDQLEEQR 6080
                              LAL   L  L   +     KA  K +L  L E+  ++L+E+ 
Sbjct: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686

Query: 6081 Q--EQALQRYRCEADELDSWLLSTKATLD---------TALSPPKEPMDMEAQLMDCQNM 6129
            Q  EQ    +     E+   L S++  L+           +   ++ +  E+        
Sbjct: 1687 QVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGS 1746

Query: 6130 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA--LHDKQ 6187
              E+ + +          E+LL   KA +  ++ ++  KL  ++  +L+ + +  L + Q
Sbjct: 1747 TAELREDLDQAKTQIGMTESLL---KALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQ 1803

Query: 6188 LNM----QGTAQEKEESDVDLTATQSPGVQ---------------EWLAQARTTWTQQRQ 6228
            +          +++ ES  DL  T+   +Q               +W +  +    +  +
Sbjct: 1804 IGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFE 1863

Query: 6229 SSLQQQKELEQEL----------------AEQKSLLRSVASR--------------GEEI 6258
            SS + +K +EQ+L                 +  S+L+ V                 G+E 
Sbjct: 1864 SS-ETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF 1922

Query: 6259 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE---DQMRMKWESLHQEFSTKQKLLQN 6315
             ++   +     A E  D L Q L ++ +  +          KW+ + +E   K +L   
Sbjct: 1923 ELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM-EEPGEKTELFCQ 1981

Query: 6316 VLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6375
             L +++EQ  +    +L + +  Y      +     T L+D       ++S      K  
Sbjct: 1982 ALARKREQ--FESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLL 2039

Query: 6376 SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD- 6434
                +Q   D       W+ +++E L V   L   E +  L  +    K+I  +  E D 
Sbjct: 2040 PTE-DQSFNDLAHDVIHWIKEIKESLMV---LNSSEGKMPLEERIQKIKEIILLKPEGDA 2095

Query: 6435 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRL-SLLDSVVNQRCHQMKERL--QQILNFQN 6491
            + + +  QA         +++ TL  +  +  + L        HQ K  L  ++ L  + 
Sbjct: 2096 RIETIMKQA---ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152

Query: 6492 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6551
            DL+++   L   +         + E+    Q++  ++     ++  + + ELK +G+ L 
Sbjct: 2153 DLRLMLIELKKKQEAGFALQHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLL 2210

Query: 6552 --VEQPSMQE--LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6607
               + PS  E    +++ +++ L+  +      L+ ++     Y+  + DL   L+   +
Sbjct: 2211 ECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSK 2270

Query: 6608 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA--VQKETQFHTE 6665
            +      +  S K   Q  +++  +  Q LE+ + L +   +KI++ A  V++ T    +
Sbjct: 2271 EF-----VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQ 2325

Query: 6666 LMAQASAVLKRAHKRGVE-------------LEYILETWSHLDE------DQQELSRQLE 6706
             + +      +  ++ +E             L  IL++    ++        +E     +
Sbjct: 2326 KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSD 2385

Query: 6707 VVESSIPSVGLVEENEDRLIDR---ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6763
            V ES+  S  + +  ED  I++   + +    + SLN  Q  +    D+ K   +     
Sbjct: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA-QESMKNTEDERKVNELQNQPL 2444

Query: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ----SESADLI-HWLQSAKDRL 6818
            +L++ L       L    K+  +L   +  +K   + +    +E+  L+ H +  +   L
Sbjct: 2445 ELDTMLRNE---QLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHL 2501

Query: 6819 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
            +   Q  +T+ +  E     L  F E+   V  +SS+K+  L T  + L++  +D+ T  
Sbjct: 2502 DNLLQALITLKKNKESQYCVLRDFQEYLAAV--ESSMKA--LLTDKESLKVGPLDSVTYL 2557

Query: 6879 SELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKD 6933
             ++ +  +   +  D L N+    E L  H   MDK      I ++      +E  IQK 
Sbjct: 2558 DKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKK 2617

Query: 6934 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 6993
                +  + Y      + K +  +I +  +Q  +       L++ S +  +         
Sbjct: 2618 YS--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALT 2669

Query: 6994 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIG 7052
              L A    + +L+G    +++ + G  E     E+ +  LK  +ET E   L+ +++I 
Sbjct: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI- 2727

Query: 7053 DQASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQ 7083
             +  ++N +K+                             C+   D I A+++ VE + +
Sbjct: 2728 KKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAE 2787

Query: 7084 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7143
                 + +      S + +TL +L   +  L     Q    L+  L++ S+      K  
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847

Query: 7144 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7203
              + E+  +L   R+ T + EA       L++    LE  ++ LQ+  S  +  L+E   
Sbjct: 2848 LMVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE--- 2897

Query: 7204 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY--------KDYSKQC---- 7251
                 LTN  +E+N+     LE   +QL++ K      QR+        +   K C    
Sbjct: 2898 -----LTNIYEELNVFERLFLE---DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFH 2949

Query: 7252 --ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHEL 7306
               S +Q++ D   R   LL    NK + ++     I +  D L  +      +  L ++
Sbjct: 2950 EKTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKV 3004

Query: 7307 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 7366
             + +    D S    +Q+      + L    +   KQ  + +     Y+     + A++ 
Sbjct: 3005 FDYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060

Query: 7367 WIVE-AEEILQGQDPSHSS---DLSTIQERMEELK---GQMLKFSSMAPDLD------RL 7413
             I +  E +L+  D S  S   +   + +R+E+ K    +++K  +     D       +
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120

Query: 7414 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
             ++      NDK  K +QN+                +L    L  +   +K ET +  L 
Sbjct: 3121 LQIKLNAEENDKLYKVLQNM--------------VLELSPKELDEKNCQDKLETSLHVLN 3166

Query: 7474 QTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSI-IIDGQRLLEQGQVDDR 7530
            Q + +L   +  N +  H+  ++   E FQ ++++    + ++  I+ QR     +  D 
Sbjct: 3167 QIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASD- 3225

Query: 7531 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 7590
                 KL    +    +      R  +++       RY+E   +        +   ++ L
Sbjct: 3226 --VETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTR--------AVESITSL 3275

Query: 7591 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQ---- 7644
             ++ IP    R      +   ++ LR+Q     TV   + L   L   S  EA LQ    
Sbjct: 3276 EAIIIPY---RVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYT 3332

Query: 7645 -AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 7703
              EL       K A    E + ++     K + K E+ I  +L K+ T   +   SLP  
Sbjct: 3333 LQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLS 3392

Query: 7704 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7763
            + E      + K L + + S  ++L +L  +   L    + +D   L + V  L  +W  
Sbjct: 3393 YREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLS 3452

Query: 7764 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 7823
            L            E   EW ++ E+ K+  EW  +  S+  +   I+++ + E+L     
Sbjct: 3453 LL-----------EAAKEWEMWCEELKQ--EW--KFVSEEIEREAIILDNLQEEL----- 3492

Query: 7824 EEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK-- 7881
             EI+  +E            A     S+  +   + G+  ++ Q LL L+  R++ ++  
Sbjct: 3493 PEISKTKE-----------AATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNV 3541

Query: 7882 -------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 7934
                   ET+ A Q++          L  ++            N E +Q ++ E+    +
Sbjct: 3542 PESSGAVETVPAFQEITSMKERCNKLLQKVQK-----------NKELVQTEIQERHSFTK 3590

Query: 7935 DI 7936
            +I
Sbjct: 3591 EI 3592



 Score = 67.0 bits (162), Expect = 8e-10
 Identities = 316/1695 (18%), Positives = 635/1695 (37%), Gaps = 300/1695 (17%)

Query: 7065 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7111
            + L+ L+K  E +    + N L + +++  E+  S   V+S  R+L +           W
Sbjct: 311  EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370

Query: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7171
              LDH +   KI L   L        A+ +    LM+   S S+    + ++  +Q ++ 
Sbjct: 371  DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428

Query: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7227
              ++L D  E     L     +T +   E H P+     N L+E+  R NN+LE+    +
Sbjct: 429  LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481

Query: 7228 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7283
             E       +L L    K  SK     ++     + ELL    +K I + E    + T  
Sbjct: 482  LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539

Query: 7284 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
            Q C ++ K L                      A     I    + +   +C   + +   
Sbjct: 540  QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577

Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
            +++LQ  +  + T+ ++L  L A   E                 T +E ++E+  + L  
Sbjct: 578  KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620

Query: 7404 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7457
             ++  +   LNE G  L     ++      K ++ LN+ W  + S+T    +       Q
Sbjct: 621  WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678

Query: 7458 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7513
             Q   +     +    +  V+    ++VE+  NY   ++    HE    E   + ++   
Sbjct: 679  DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737

Query: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573
               D ++L+ Q ++                W+       + + ++D    Q      M E
Sbjct: 738  ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768

Query: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7633
             L+  + + S                   +FDE+  + +  L+     I + E+ + +L 
Sbjct: 769  SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809

Query: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
            +        LQA++ E +EK +   ++L    K L  +  D +   K + +S ++L ++ 
Sbjct: 810  T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861

Query: 7694 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7753
             +  Q L          ++  K  E  + S T  L +     + L   ++ D    L E+
Sbjct: 862  MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918

Query: 7754 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7813
               +  +WE L H+LSL  QQ+        +  EK K L + + ++E ++++   ++   
Sbjct: 919  SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970

Query: 7814 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872
              + L K++  E   ++E  + QL    E L +   E  + + + ++ ++   ++  ++ 
Sbjct: 971  RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028

Query: 7873 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932
            +   +K   E  + +Q      S     +   E+    P      +SE    K + Q   
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079

Query: 7933 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7990
            ++ +E      +ASVL  L E  + + D  A      SI       D  +R+I    +E 
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128

Query: 7991 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 8050
             L+  +      +   D+S  ED  +SS    A  +   VI        K+FE    ++ 
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181

Query: 8051 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8110
              +     I K +    R+   +    L+  +   N R ++L+  +  +L          
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225

Query: 8111 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8170
                  + S+L+  +++ L    I+ F   D     + L+  Q  I+       ++   G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282

Query: 8171 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8230
              ++++  P D   ++  + + +   + +  RV+R    L                    
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322

Query: 8231 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER-SGRDTPASVDSIPLEWDHDY 8289
               AL D     R+A   LS +P ++LS S  Q  +    + ++    +  +  +  H  
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD 1378

Query: 8290 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHS-ALESQIRQLGKALDDSRFQ 8348
               + L+ +   A   +D   ++  D +   ++ LS  H   ++ +  +  K L+   F+
Sbjct: 1379 KCLKMLDMSFKDAERGDDTSCENLLDAF---SIKLSETHGYGVQEEFTEENKLLEACIFK 1435

Query: 8349 ----------IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 8398
                      +Q   + I  K PT P +    K  ++L       +D  +  +  L+E  
Sbjct: 1436 NNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRL----DKVLDEYEEEKRHLQEMA 1491

Query: 8399 ESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8453
             SLP F +    +   Q    +  WE    L  + L +  R+ + L+++Q F S L +  
Sbjct: 1492 NSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTT-- 1549

Query: 8454 AWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC--- 8505
              L   EE +  LQ     +  L   I  IE+  ++  E  + VD    +  ++      
Sbjct: 1550 --LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNK 1607

Query: 8506 -----SPEFTQAD----------SKESRDLQDRLSQMNGRWDRVCSL---LEEWRGLLQD 8547
                  P F +            ++++ D  + L +    WD++ +L   ++EW     +
Sbjct: 1608 MKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEW----TE 1663

Query: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQL 8607
              +Q    H+++       E+ +R K E+      +  +   +  +++ +I+  L  S++
Sbjct: 1664 KALQKMELHQLTE------EDRERLKEEL-----QVHEQKTSEFSRRVAEIQFLLQSSEI 1712

Query: 8608 RVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKLLLKEVSRHIKELEKLLDVS 8663
             +  LQ M   +L   E    CL  +   H +      L+  L +    I   E LL   
Sbjct: 1713 PL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKAL 1771

Query: 8664 SSQQDLSSWSSADEL 8678
            S    L  ++  +E+
Sbjct: 1772 SPSDSLEIFTKLEEI 1786



 Score = 57.8 bits (138), Expect = 5e-07
 Identities = 88/534 (16%), Positives = 217/534 (40%), Gaps = 51/534 (9%)

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
            + +  GE+ L +++ + +  +  ++  L++ W D+           +S +  W+   ++ 
Sbjct: 5760 LTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKI 5819

Query: 2743 NQLEQWMESVDQKIEHPL-QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
             +L+  ++ +  + E PL +    L  +  L+  L+  L+    + + L  + A     +
Sbjct: 5820 KELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTR-H 5878

Query: 2802 EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKE 2861
               ED        E L  Q+ D+      + +++E+ +   +++ +   E   WL   + 
Sbjct: 5879 VLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMEN 5938

Query: 2862 ELHRWSDMSGDSSATQKKLSKI-KELIDSREIGASRLSRVESLAPEVKQNTTASGCELMH 2920
            ++ + +D+S      ++ + K+ K+ ++   + +    +++ +  ++ + +  S    + 
Sbjct: 5939 KVLQTADIS-----IEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEID 5993

Query: 2921 TEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWA 2980
             ++  +   W+   D +    S ++ L    A  +Q            L++  + L+TW 
Sbjct: 5994 DKLNKINDRWQHLFDVI---GSRVKKLKETFAFIQQ------------LDKNMSNLRTWL 6038

Query: 2981 QQLTLLEGKNT------DEEIVECWHKGQEILDALQKAEPRTE------DLKSQLNELCR 3028
             ++     K        D+EI +   + Q++   +++     E      D+    ++ C 
Sbjct: 6039 ARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACA 6098

Query: 3029 FSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQI--LQQRFRKAFRDFQQWLVNAKIT 3086
               +  +       L + +  +C  + +     E+   L Q+F   +  F+ WL +A+  
Sbjct: 6099 NETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAE-R 6157

Query: 3087 TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTK-------EK 3139
            TA C     N SEV  +  K  E L   E  Q +++  L++ EL++    +       + 
Sbjct: 6158 TAAC----PNSSEVLYTSAK--EELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDT 6211

Query: 3140 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE 3193
            A  ++  V    + W N    +      L +   Q ++FE + E I  WL++ +
Sbjct: 6212 ASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMD 6265



 Score = 41.2 bits (95), Expect = 0.046
 Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)

Query: 8421 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
            W  LQ + L K L+  +N   ++++NS L+ + ++    EE+   L  L +  D+  ++ 
Sbjct: 305  WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361

Query: 8481 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8536
               +L+E    +DH+  A  + +N   P     T+A  +E  +L D     +    +  +
Sbjct: 362  DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421

Query: 8537 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8596
            L++E   L +  + +     E    +LL  EN D     +VP                  
Sbjct: 422  LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459

Query: 8597 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8644
               ++L E + R+ ++ +    LL+      CL      E K K+ +     G+R  ++L
Sbjct: 460  --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517

Query: 8645 LLKEVSRHIKELEKLLDVSSSQQ 8667
            LL++  + I+E E L  + +S Q
Sbjct: 518  LLEDWHKFIEEKEFLARLDTSFQ 540



 Score = 39.3 bits (90), Expect = 0.17
 Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)

Query: 316  DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 374
            ++ + KE++  +  + ++L   Q ++++L       +H  V+  M  K QIEHL    HR
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896

Query: 375  DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 431
              + L L  A+ KQ    +  RL  W +  +K+       + AWL + E  V    +I++
Sbjct: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948

Query: 432  QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 491
            +++ E+       ++    +   N    K+   ++ +  + +      D+L  + +R+  
Sbjct: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005

Query: 492  VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 542
            +       + K   L+  +  +  L    S L++W+ +     S          +++ + 
Sbjct: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062

Query: 543  YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 599
                 +  +  EQ+    + +    ++ +    A  +  E +++ +       +WRN+  
Sbjct: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122

Query: 600  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 646
                 R  +EE    W ++ +  +  + WL+ AE+     N SE    +AK++      F
Sbjct: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182

Query: 647  FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 705
             R +   + Q   +N     L        +  LKQ +   N RW  L   V     +   
Sbjct: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242

Query: 706  MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 764
                ++E+     ++  + TE   +L+     S  +    ++ L   +Q + +   +  +
Sbjct: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302

Query: 765  IITKTAHLITKESP 778
            +I     LI K  P
Sbjct: 6303 LIVFGEQLIQKSEP 6316



 Score = 35.4 bits (80), Expect = 2.5
 Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)

Query: 1444 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1498
            +K       S+   ++ W+ + E EL  L+ +    D+Q  +++V  +QEI    ++  +
Sbjct: 6549 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6608

Query: 1499 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1558
             +V +   ++ F Q   + ES  ++++L Q+    E  +       G +   L Q Q F 
Sbjct: 6609 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6667

Query: 1559 E 1559
            +
Sbjct: 6668 Q 6668


>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
            [Homo sapiens]
          Length = 982

 Score = 1890 bits (4895), Expect = 0.0
 Identities = 959/982 (97%), Positives = 959/982 (97%), Gaps = 23/982 (2%)

Query: 7839 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7898
            MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60

Query: 7899 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7958
            TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120

Query: 7959 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 8018
            ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180

Query: 8019 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8078
            ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 181  ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240

Query: 8079 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8138
            KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 241  KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300

Query: 8139 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8198
            ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360

Query: 8199 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 8258
            VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420

Query: 8259 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8318
            LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480

Query: 8319 RGAVGL-----------------------SGDHSALESQIRQLGKALDDSRFQIQQTENI 8355
            RGAVGL                       SGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540

Query: 8356 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8415
            IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 541  IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600

Query: 8416 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8475
            GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 601  GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660

Query: 8476 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
            QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 661  QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720

Query: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
            SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780

Query: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
            MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840

Query: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
            LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 841  LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900

Query: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8775
            HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 901  HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960

Query: 8776 LSNNFARSFHPMLRYTNGPPPL 8797
            LSNNFARSFHPMLRYTNGPPPL
Sbjct: 961  LSNNFARSFHPMLRYTNGPPPL 982



 Score = 77.4 bits (189), Expect = 6e-13
 Identities = 136/853 (15%), Positives = 335/853 (39%), Gaps = 71/853 (8%)

Query: 3572 LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS-PRTRRQSN 3630
            L  +   WQ     ++    +    +  ++ +++    +  WL   E +++ P      N
Sbjct: 21   LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCN 80

Query: 3631 RATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMG-CQATQ-----LTS 3684
                + +L++ ++   ++  +   V  V    + +L +    +    C + Q     L  
Sbjct: 81   SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 140

Query: 3685 RYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMG 3744
            R++ +    +E+   +EE  +  ++     S + DW  S+ +     ++    V   +  
Sbjct: 141  RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS--GVIYTVAK 198

Query: 3745 KKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV 3804
            ++LK  E   + + +  + L+   ++  R  +      A  L++ +H+  ++   L   V
Sbjct: 199  EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 258

Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
                  L+  +   +EF     ++  W+ E    L +         + +A++ + K+ QQ
Sbjct: 259  TSILRRLKHFIGQREEFETARDSILVWLTEMD--LQLTNIEHFSECDVQAKIKQLKAFQQ 316

Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT---LKDKIDQLQSDYQDLCS-IGKEHVFSLEAK 3920
             +  +   ++ +  +GE L+E  + +    +++++D+L+   Q++   + + H   +   
Sbjct: 317  EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 376

Query: 3921 VKDHE----DYNSELQEVEK-----WLLQMSGRLVAPDLLETSSLETITQQLAHHKAMME 3971
            + D E    D   EL++        W  + +  L++P      SL ++ Q L   ++  +
Sbjct: 377  LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL-SLAQPLRSERSGRD 435

Query: 3972 EIAGFE------DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQ 4025
              A  +      D   +L    ++ + +       + + +   +L+G       +   + 
Sbjct: 436  TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 495

Query: 4026 RMYQSLEHELQKHVS----------RQ------DTLQQCQAWLSAVQPDLEPSPQPPLSR 4069
              Y  L     K+ S          RQ      D+  Q Q   + ++      P+   S 
Sbjct: 496  EAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY 555

Query: 4070 -------AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QTI 4118
                    E    +   + L+ + +   + L    +L +   +T A  I + E    Q +
Sbjct: 556  KGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT-AGVIDRWELLQAQAL 614

Query: 4119 EQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
             ++L   QNL Q W++     + +W +L D +++L+ ++R     ++   +  + ++K+ 
Sbjct: 615  SKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL 673

Query: 4179 VKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4235
             K +  ++A   S+N    +  +   KE       ++ +N +W  +C          ++ 
Sbjct: 674  QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDA 733

Query: 4236 LQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQERKYA 4291
            L + + +H+  + + + LE      + +    +  DAE    H + L ++   L E +  
Sbjct: 734  LMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 793

Query: 4292 IEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQS 4351
            +  L+D   +++ +    D    KE+   +  R      L+ +++   +  LE+L  V S
Sbjct: 794  VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKLLDVSS 849

Query: 4352 RFQELMEWAEEQQ 4364
              Q+L  W+   +
Sbjct: 850  SQQDLSSWSSADE 862



 Score = 73.9 bits (180), Expect = 6e-12
 Identities = 156/844 (18%), Positives = 338/844 (40%), Gaps = 70/844 (8%)

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICS-SATETYKVLQEHMDLCQALESLSSAITAFS 1613
            Q+ ++N+  ++  ++  E +LA PI   S ++ E  + L E  +L + +E  S+ + +  
Sbjct: 50   QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 109

Query: 1614 ASARKVVNR-DSCVQEAAA---------LQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
                 +++  D+C  +A           L +++ +I   + ER+  +E     WQ+   +
Sbjct: 110  NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 169

Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
             S F  WL+  E  A+ P        V  E EL+  +A Q +V    +    + +    L
Sbjct: 170  YSRFEDWLKSSERTAAFPSSSGVIYTVAKE-ELKKFEAFQRQVHECLTQLELINKQYRRL 228

Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
                  D    +K  + + ++RW +L + +   +  L+  + + ++F+    S  VW+  
Sbjct: 229  ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTE 288

Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
               +L      S  D Q  + + K    E+     +++ +     +L       D  +++
Sbjct: 289  MDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348

Query: 1844 GKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESD 1903
             + ++  +  +E    VER    L  L      H              + ++   + E  
Sbjct: 349  EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH--------------DLSDRELELEDS 394

Query: 1904 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1963
                DL+   ++A +L S   S +  LS AQ    + S        A+ D +  E +   
Sbjct: 395  AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ---PLRSERSGRDTPASVDSIPLEWDHDY 451

Query: 1964 NLLGTKQSE-ADALAVLKKAFQDQKEELLK---SIEDIEERTDKERLKEPTRQALQQRLR 2019
            +L    +S  + AL    +  QD K+  L+    + D+      E   + T  A++    
Sbjct: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 511

Query: 2020 VFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQG 2079
              + LE ++         L D   QI Q +     +       L+ ++    +L+    G
Sbjct: 512  DHSALESQIRQLGKA---LDDSRFQIQQTENIIRSKTPTG-PELDTSYKGYMKLL----G 563

Query: 2080 QCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2139
            +C   ID ++  ++      + L    ++  T T      D +W   + +    ++  KQ
Sbjct: 564  ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID-RWELLQAQALSKELRMKQ 622

Query: 2140 ---------KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2190
                      DL++  +       EL+++   + S     +E  + K L   +K  ++  
Sbjct: 623  NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKK-LKELQKAVDHRK 681

Query: 2191 RLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALR 2250
             + +S+++     +  D  E  S +   ++++     D   R   LL+E+   +++  ++
Sbjct: 682  AIILSINLCSPEFTQADSKE--SRDLQDRLSQMNGRWD---RVCSLLEEWRGLLQDALMQ 736

Query: 2251 LEELHSKVNDLKELTKNL-----ETPPDLQFIEADLMQKLEHAKEIT----EVAKGTLKD 2301
             +  H   + L  + +N+     E  P    ++A+++Q  +H K++     E+ +  L+ 
Sbjct: 737  CQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ--DHHKQLMQIKHELLESQLRV 794

Query: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQE 2361
             + Q    +  +N   T   + +E  ++   N     LK+V    KEL+ +  ++SS+Q+
Sbjct: 795  ASLQDMSCQLLVNAEGTDCLEAKEK-VHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQ 852

Query: 2362 NLNS 2365
            +L+S
Sbjct: 853  DLSS 856



 Score = 72.0 bits (175), Expect = 2e-11
 Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)

Query: 7628 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 7687
            G++L  ++     + ++ +L ++ ++W+     +  + KKL   L   ++ +K ++    
Sbjct: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61

Query: 7688 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7740
             L   + +L++ +        +   +L+ +Q   +++E         L    +L     A
Sbjct: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121

Query: 7741 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7800
              +  +   + +    L R+W  +C     RR +I E    W  F +      +WL   E
Sbjct: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181

Query: 7801 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 7856
               +   +  ++     E+LKK   +Q ++         + +   RLA+ +    A  ++
Sbjct: 182  RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241

Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7916
              + + N RW +L   + + +++LK  +   ++ +    S+  WL  ++ +L     +  
Sbjct: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301

Query: 7917 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 7971
            C   ++Q K+ + +  Q++I  +   +  ++   E L+      DA   + E D +++
Sbjct: 302  C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356



 Score = 71.2 bits (173), Expect = 4e-11
 Identities = 150/846 (17%), Positives = 321/846 (37%), Gaps = 109/846 (12%)

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECW--HKGQEILDALQKAEPRTEDLKSQL 3023
            +  L+  +A +K   + L  ++  + +   +  W  H   E+   +      +E+++ +L
Sbjct: 29   QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKL 88

Query: 3024 NELCRFSRDLSTYSGKVSGLIKE-----YNCLCLQASKGCQNKEQI-------------- 3064
            NE     RD+  +S  V+ ++       ++C        C + +Q               
Sbjct: 89   NEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 148

Query: 3065 -------------LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFL 3111
                         L Q+F   +  F+ WL +++ T A         +     L+K + F 
Sbjct: 149  SMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQ 208

Query: 3112 SESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENL 3171
             +      +L ++  +   L+     + A  ++  V    + W N    +      L++ 
Sbjct: 209  RQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 268

Query: 3172 KIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3230
              Q ++FE + + I  WL++ + ++ +       D+ AK ++ +  Q   +EI     ++
Sbjct: 269  IGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKI 325

Query: 3231 NRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLG 3288
             ++  + +QL E      +      + +L      +    +    +L R+    ++  L 
Sbjct: 326  EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385

Query: 3289 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV 3347
             +EL+  + D+  + D + H  S  S+L  + +  L   L+     E   +      +S+
Sbjct: 386  DRELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 443

Query: 3348 -------------LQNTSPEGIPTIQQQLQSVKDMW----ASLLSAGIR---------CK 3381
                         L++     +P+  ++ Q  KD +      L    I           +
Sbjct: 444  PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503

Query: 3382 SQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAK 3433
            + ++      ++ +  +RQ    +D     + ++E     +R KT        +  G  K
Sbjct: 504  NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMK 560

Query: 3434 LLNEEVLSYSSL------LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
            LL E   S  S+      L+  E    G    + T+ +   + +R+  +Q +A     + 
Sbjct: 561  LLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRM 620

Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEG 3545
            ++ ++  Q++  DL +   WLG  +E+L+Q   LE   D  T E  ++ L+ELQ      
Sbjct: 621  KQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR 680

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
            +A++ S+     +   +     E R L+           R+     ++  ++    +  Q
Sbjct: 681  KAIILSINLCSPEFTQA--DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 738

Query: 3606 KFQQVDEWLKTAEEKVSPRTRR----QSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGAR 3661
             F ++   L    E +  R        SN   + +Q H     H+++   + E+ E   R
Sbjct: 739  GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDH-----HKQLMQIKHELLESQLR 793

Query: 3662 AQEILDES---HVNSR-MGCQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESES 3712
               + D S    VN+    C   +     + +R + LL +V   IK L E++  +  S+ 
Sbjct: 794  VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQ 852

Query: 3713 SLSSYS 3718
             LSS+S
Sbjct: 853  DLSSWS 858



 Score = 70.1 bits (170), Expect = 9e-11
 Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)

Query: 7196 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 7255
            +L K  H      +   L +VN RW +LL+ IA +++  K  L   Q+     K  +S  
Sbjct: 4    RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60

Query: 7256 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 7315
                   +EL K         +E+   + +  +L + +      +  +  L E L    D
Sbjct: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120

Query: 7316 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7368
            A A  A    IQ    +L    +++CA+     +++  ++     ++ F       E W+
Sbjct: 121  ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177

Query: 7369 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 7425
              +E       PS S  + T+ +E +++ +    +       L+ +N+   RL   ++  
Sbjct: 178  KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235

Query: 7426 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7481
                +K+M    N+ W  +  + T    +L+ F+ Q + F    ++ + +L + + +L  
Sbjct: 236  SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294

Query: 7482 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7536
                N +H  E   Q +  +L  FQ E+      +  II  G++L+E+ +  D      +
Sbjct: 295  ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350

Query: 7537 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 7581
            L  L    Q V  R ++      R  + D +     R  E+ +           R     
Sbjct: 351  LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410

Query: 7582 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 7640
            +S  P S L  S+  PL+  R+  D     + + L     Y L+ +    +  +  S  E
Sbjct: 411  LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470

Query: 7641 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 7699
                 +   ++     + + + E  +    L ++  K   G   +LE ++R   K L  S
Sbjct: 471  EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530

Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 7754
                       + + ++ EN + S T      D +    +K       S D +  L  ++
Sbjct: 531  -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579

Query: 7755 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 7794
            +  +                     +WE L  Q   +  ++ + L +W  F+     +  
Sbjct: 580  KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639

Query: 7795 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7848
            WL   E ++ Q      + DI   E+  K  K+ Q+ +   +   + +        +A  
Sbjct: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698

Query: 7849 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7908
              ++ +++ +L ++N RW  +  L+      L++ L+  Q   +    L   L +I+   
Sbjct: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758

Query: 7909 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 7955
             + +  DS  ++E +Q    +  +++ ++ +    VAS+ ++ C++L++
Sbjct: 759  NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807



 Score = 65.5 bits (158), Expect = 2e-09
 Identities = 129/808 (15%), Positives = 321/808 (39%), Gaps = 88/808 (10%)

Query: 2273 DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLM---- 2328
            ++++    +  + +H  ++       LK+      Q++K ++ + TW   +E  L     
Sbjct: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75

Query: 2329 --NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESLGRAM 2382
              +C   E    L + +++Q++++   + ++S       L     +    AE +S+ +A 
Sbjct: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135

Query: 2383 TGLIKKHEAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSK 2440
              L ++   +  +  + +  ++E+  L + F +    F++W   ++  A   S       
Sbjct: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195

Query: 2441 VLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFL 2500
            V + +L   +     V +  ++L+ + ++ + L          S+++ + + N+ +    
Sbjct: 196  VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 255

Query: 2501 KQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME-ERFNTENLGESKQHIPEKKNEVHK 2559
            K+     + L+    +   FE     + +W+ EM+ +  N E+  E      + + ++ +
Sbjct: 256  KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-----DVQAKIKQ 310

Query: 2560 VEMFLGELLAARESLDKLSQRGQLLSEEG---------HGAGQEGRLCSQLL----TSHQ 2606
            ++ F  E+      ++++  +G+ L E+              +  R C ++       H+
Sbjct: 311  LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370

Query: 2607 NLLRM----TKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
             L+R+     +  L   ++ L++  AL +       W     D L   + +     +L +
Sbjct: 371  KLIRLPLPDDEHDLSDRELELEDSAALSDL-----HWHDRSADSLLSPQPSSNLSLSLAQ 425

Query: 2663 RLSQIQ---------DILLMKGEGEVKLNMAIGKG-EQALRSSNKEGQRVIQTQLETLKE 2712
             L   +         D + ++ + +  L+  +     +AL S ++EGQ      L     
Sbjct: 426  PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVG 485

Query: 2713 VWADIM---SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD------QKIEHPLQPQ 2763
            + +D+M   S   + + T  ++ +   D+   ++Q+ Q  +++D      Q+ E+ ++ +
Sbjct: 486  L-SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544

Query: 2764 -PGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKT--- 2819
             P   E          +L E      ++ RL  K +E  E+     F +    E +T   
Sbjct: 545  TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGV 602

Query: 2820 --QFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS--DMSGDSSA 2875
              ++  +   A  K  ++++ ++    +   ++    WL   +EEL +    ++S D   
Sbjct: 603  IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662

Query: 2876 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2935
             + ++ K+KEL  + +   + +  +   +PE  Q  +    +L    +  +   W +   
Sbjct: 663  IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMNGRWDRVCS 721

Query: 2936 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 2995
             + + +  L++ + Q     +   G +  LE    + + ++             N D EI
Sbjct: 722  LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---------DSNLDAEI 772

Query: 2996 VECWHKGQEILDALQKAEPRTEDLKSQL 3023
            ++  HK        Q  + + E L+SQL
Sbjct: 773  LQDHHK--------QLMQIKHELLESQL 792



 Score = 62.0 bits (149), Expect = 3e-08
 Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)

Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
            S++E +L ++ + W    + ++  + +L+  L    +     + L  WL   +  L    
Sbjct: 15   SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71

Query: 6823 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 6877
            +  V      E ++  LN   E  ++++  S+  +SVL+    LL          +  ++
Sbjct: 72   KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            +     +D +W ++       + K+ +            S    W+   E        + 
Sbjct: 132  QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
               + Y    E L+K++ F+  ++     ++ +N+   +++       R ++TD A  L 
Sbjct: 191  --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241

Query: 6998 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 7053
             M    N+ W  LQ  VT  ++ L+  +    E+E     +  W    + +L        
Sbjct: 242  QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300

Query: 7054 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 7113
            +  VQ  +K  +  +  I     ++E+I   G  LI+  +   ++I+   L EL +    
Sbjct: 301  ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360

Query: 7114 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 7152
            +                   +H +   ++ L+  + L     H  + D + S    +  S
Sbjct: 361  VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420

Query: 7153 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 7187
            LS  + L           S++++ ++ D+  +L  DLE                 ++  L
Sbjct: 421  LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480

Query: 7188 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 7247
            +    +++ ++ E      +   N +K  +   + L  +I    Q  KAL        D 
Sbjct: 481  RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529

Query: 7248 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 7307
            S+     +QQ E+      K  T  ++ D     +++   +    + +VK     L E  
Sbjct: 530  SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583

Query: 7308 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 7367
            E L   V+  +     +  +   + L A  QAL K +  ++  +  ++ F   L ++ AW
Sbjct: 584  ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640

Query: 7368 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 7416
            + + EE L Q Q    S+D+ TI+ ++++L          K  +L  +  +P+  + +  
Sbjct: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700

Query: 7417 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 7466
              R  L D    R+  +N  W  + S   E    LQ  L+Q Q F          LE  +
Sbjct: 701  ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755

Query: 7467 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 7504
                 +V  +  L  EI  ++   L Q + HEL ++++
Sbjct: 756  RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 149/812 (18%), Positives = 306/812 (37%), Gaps = 114/812 (14%)

Query: 3463 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3522
            + +L  + +R++ + +     V K ++ +   Q+  +++ +   WL   + +L +  V +
Sbjct: 18   EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 77

Query: 3523 G-DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD--- 3578
              ++   +  L + QELQ    +    + SVL+  E ++      A D   +S++Q    
Sbjct: 78   SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 137

Query: 3579 ----WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS-PRTRRQSNRAT 3633
                W+       E R +        +     + + ++WLK++E   + P +        
Sbjct: 138  LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 197

Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT----SRYQAL 3689
            KE +L + + +  +V     ++E +  + + +  E+  +S   C   Q+      R+  L
Sbjct: 198  KE-ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNL 254

Query: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
              +V   ++ L+  I   EE E++  S   W         N    I+      +  K+K 
Sbjct: 255  QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQ 310

Query: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHM 3809
            L+   +++   H+ ++    +GE+ ++  E  +A  + +E+ +     +E+   V + H 
Sbjct: 311  LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370

Query: 3810 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3869
             L +      E     + L    +     LH  +     L   +   +   SL Q + S 
Sbjct: 371  KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430

Query: 3870 E------PSVKSVREKGEALLELVQD--------VTLKDKIDQLQSDYQDLCSIGKEHVF 3915
                    SV S+  + +   +L +D        +  +D+  Q   D+    ++G   V 
Sbjct: 431  RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 490

Query: 3916 ---SLEAKVK-----------DHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
               S EA VK           DH    S+++++ K L     ++   + +  S   T  +
Sbjct: 491  IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 550

Query: 3962 QLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCAD------HLQAKLKQ---------NV 4006
                +K  M+                  L+G+C+        L+ KLK+         N+
Sbjct: 551  LDTSYKGYMK------------------LLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 592

Query: 4007 HA---HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSP 4063
            H+      G  D +  + + A      ++  LQK       L    AWL   + +LE   
Sbjct: 593  HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 652

Query: 4064 QPPLSR-AEAIK-QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4121
            +  LS   + I+ Q+K  + LQ+       ++ S+   S    +  +K+ +  +  + Q 
Sbjct: 653  RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ- 711

Query: 4122 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQ--------------LQNMKRRHSE----- 4162
                  +   W+ +  L  E    LQDA  Q              L+N+ RR +E     
Sbjct: 712  ------MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 765

Query: 4163 --LELNIAQNMVSQVKDFVKKLQSKQASVNTI 4192
              L+  I Q+   Q+     +L   Q  V ++
Sbjct: 766  SNLDAEILQDHHKQLMQIKHELLESQLRVASL 797



 Score = 59.7 bits (143), Expect = 1e-07
 Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)

Query: 7518 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 7577
            G+RL +        E   KL  ++++WQ ++     R   +   +   Q+  +    LR 
Sbjct: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61

Query: 7578 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 7637
            WL  +       +       ++ +   +E Q  ++   +        +   + LL   D+
Sbjct: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121

Query: 7638 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7693
             A  A    +Q     +  +W++      E++ K+    + W+K     +   + L++ +
Sbjct: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181

Query: 7694 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 7749
            +  + + P     ++   +   K+ E       + LTQL L+      L+     D    
Sbjct: 182  R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239

Query: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 7806
            L + V    ++W+ L  +++   +++   + +   F      +  WLT+M+   + +   
Sbjct: 240  LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299

Query: 7807 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
             +  ++  I++LK  +Q+EI++      Q+   GE+L + S    A+ IE +L ++    
Sbjct: 300  SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358

Query: 7867 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 7903
            Q +   +    KKL                   E   A+  L   D++  SL +    ++
Sbjct: 359  QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418

Query: 7904 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 7957
            +   LA+P+  +        + + I  + +   +L RD+E  S    ++ +  E    D 
Sbjct: 419  LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476

Query: 7958 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 8014
            D     A   S   I ++     +   N    +      +E   R   K LDD SRF+  
Sbjct: 477  DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533

Query: 8015 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 8072
            ++ +E      + +G       E    ++ + + + EC + ++ + +   +L  E  +  
Sbjct: 534  IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587

Query: 8073 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 8130
               +  S +        RW+ LQ +  S   R+K  + + ++F +  +SI  WL + + +
Sbjct: 588  GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647

Query: 8131 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 8162
            L  ++      D+Q    +IK+LK  Q+  +++H K
Sbjct: 648  LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681



 Score = 58.5 bits (140), Expect = 3e-07
 Identities = 163/931 (17%), Positives = 353/931 (37%), Gaps = 144/931 (15%)

Query: 5070 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            ++E K+  +  R Q +     A+V  L+          K    +   +   E +L++  +
Sbjct: 16   EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL----EEKASQLEKTGNDASKATLSRSM 5185
              + +S E + KL+E + L   +      + ++    E      +    DA   ++ ++ 
Sbjct: 76   YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135

Query: 5186 TTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKA 5245
              + +RW  + A++ ++   +E+    W  F +   +  + +   +      S+      
Sbjct: 136  RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195

Query: 5246 ELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
                 L+  + F  ++ +  + L ++ +Q   + ++    +      L Q +     R  
Sbjct: 196  VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS---LKQMVHEGNQRWD 252

Query: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN----PTIEIDAQLEELQ 5361
            N+Q++V +  + +K  +  RE  ET  +S+  W+ E    L N       ++ A++++L+
Sbjct: 253  NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK 312

Query: 5362 ILLTEATNHRQNIEKM------------------------------------AEEQKEKY 5385
                E + +   IE++                                     E   +K 
Sbjct: 313  AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372

Query: 5386 LGL------YTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQK--- 5436
            + L      + +   EL L+ +    DL   D+  D +   + S   S  L++ ++    
Sbjct: 373  IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 432

Query: 5437 --------------------LAKDLTTILTKLKAKTDNVVQAKTD---------QKVLGE 5467
                                L++DL + +++     D   Q   D           V+  
Sbjct: 433  GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIP 492

Query: 5468 ELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAAS 5527
            E      KL E   A++     +  L   + +++GK  +  +  I+Q EN +        
Sbjct: 493  ESPEAYVKLTE--NAIKNTSGDHSALESQI-RQLGKALDDSRFQIQQTENIIRSKTPTGP 549

Query: 5528 HLEE----YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS-- 5581
             L+     Y ++L      I+  K L H          L     LH T  + +  ID   
Sbjct: 550  ELDTSYKGYMKLLGECSSSIDSVKRLEHK--LKEEEESLPGFVNLHSTETQTAGVIDRWE 607

Query: 5582 --ELEAMTEKLQYLTSVYCTEKMSQQV----AELGRETEELRQMIKIRLQ-NLQDAAKDM 5634
              + +A++++L+   ++   ++ +  +    A LG   EEL Q+ ++ L  ++Q     +
Sbjct: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667

Query: 5635 KKFEAELKKLQAALEQAQA-----TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 5689
            KK    LK+LQ A++  +A      L SPE  +   KE     Q  LS+M     +V   
Sbjct: 668  KK----LKELQKAVDHRKAIILSINLCSPEFTQADSKES-RDLQDRLSQMNGRWDRV--C 720

Query: 5690 QLCQSALRIPEDVVASL----PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5745
             L +    + +D +        + H  L + E   R ++  +   + + A ++Q      
Sbjct: 721  SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ------ 774

Query: 5746 EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKML 5805
               H +QL++  H E+ +  +  +++Q++  Q+  + E    ++  +E++  + ++ K+L
Sbjct: 775  --DHHKQLMQIKH-ELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLL 830

Query: 5806 TMK-AKHATMLLTVTEVEGLAEGTE--------DLDGELLPTPS-AHPSVVMMTAGRCH- 5854
              + ++H   L  + +V    +           D  G + PT   + P+      G+C  
Sbjct: 831  LKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSL 890

Query: 5855 ----TLLSPVTEESGEEGTNSEISSPPACRS 5881
                  +S     S + G++S +S P   RS
Sbjct: 891  SQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS 921



 Score = 58.2 bits (139), Expect = 4e-07
 Identities = 181/887 (20%), Positives = 351/887 (39%), Gaps = 150/887 (16%)

Query: 1191 LTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELIS 1250
            L + S E++A +   +L K++  ++ L+ L++   K L      VQ  +   +SL   ++
Sbjct: 5    LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64

Query: 1251 GSKEVQEQAEK--ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQ----QGEG 1304
                ++ +  K  + D+ N  E Q+ L   Q+  + I      V   +   +      + 
Sbjct: 65   ---HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121

Query: 1305 GLPDRGHEELRKLESTLDGLERS--RERQERRIQV--TLRKWERFETNKETVVRYLFQTG 1360
               D   + +++    LD   R+      ERR+++  T R W++F  +      +L    
Sbjct: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL---- 177

Query: 1361 SSHERFLSFSSLESL-----SSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL 1415
             S ER  +F S   +       EL++ + F ++      Q E + K+     L  +N+  
Sbjct: 178  KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR--LARENRT- 234

Query: 1416 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHF---GSNFET----LSVWITEKEKE 1468
                A S+K+ V +     +   K +  +  +  HF      FET    + VW+TE + +
Sbjct: 235  --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292

Query: 1469 LNALETSSSA-MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
            L  +E  S   +  +I Q+K   QEI    + I  +  + +   +     ++A I+ +L 
Sbjct: 293  LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352

Query: 1528 QIRRYGEEL-----REHAQCL-------------------EGTILGHLSQQQKFEENLRK 1563
            ++RRY +E+     R H + +                   +   L  L    +  ++L  
Sbjct: 353  ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412

Query: 1564 IQQSVSEFEDKLAVPIKICSSATETYKVL-------QEHMDLCQALES-LSSAITAFSAS 1615
             Q S S     LA P++   S  +T   +           DL + LES +S A+ +    
Sbjct: 413  PQPS-SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471

Query: 1616 ARKVVNRDSCVQEAAALQ------------QQYEDILRRAKERQTALENLLAHWQRLEKE 1663
             +   ++D  ++ A  L             +  E+ ++      +ALE+ +   ++L K 
Sbjct: 472  GQD--DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI---RQLGKA 526

Query: 1664 LSSFLTWLERGE-----AKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQ 1718
            L      +++ E        + PE+D S      +G ++L+    + + S      KL +
Sbjct: 527  LDDSRFQIQQTENIIRSKTPTGPELDTS-----YKGYMKLLGECSSSIDSVKRLEHKLKE 581

Query: 1719 LKESLFSVASKDDVKMMKLHLEQLDERWRDL-PQIINKRINFLQSVVAEHQQFDELLLSF 1777
             +ESL       ++   +     + +RW  L  Q ++K +   Q+ + + QQF+  L S 
Sbjct: 582  EEESLPGFV---NLHSTETQTAGVIDRWELLQAQALSKELRMKQN-LQKWQQFNSDLNSI 637

Query: 1778 SVWI------KLFLSELQTTSEISIMDHQV----ALTRHKDHAAEV------------ES 1815
              W+         L  L+ +++I  ++ Q+     L +  DH   +            ++
Sbjct: 638  WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 697

Query: 1816 KKGELQSLQGHLAKL-GSLGRAEDL-----HLLQGKAEDCFQLFEEAS-------QVVER 1862
               E + LQ  L+++ G   R   L      LLQ     C Q F E S       + ++R
Sbjct: 698  DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC-QGFHEMSHGLLLMLENIDR 756

Query: 1863 RQLALSHL-----AEFLQS-HASLSGILRQLRQTVEATNSMNKNESD-LIEKDLNDALQN 1915
            R+  +  +     AE LQ  H  L  I  +L ++     S+       L+  +  D L+ 
Sbjct: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816

Query: 1916 AKALESAAVSLDGILSKAQYHLK-------IGSSEQRTSCRATADQL 1955
             + +      L  +L +   H+K       + SS+Q  S  ++AD+L
Sbjct: 817  KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863



 Score = 58.2 bits (139), Expect = 4e-07
 Identities = 139/794 (17%), Positives = 312/794 (39%), Gaps = 85/794 (10%)

Query: 6559 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 6618
            +L K+ D +  L+ +I +R   L + L    Q ++ +  L   L   + ++A        
Sbjct: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79

Query: 6619 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 6667
            + EEIQ+ L++ +E  + +E H       + L E L     + A   E     Q    L 
Sbjct: 80   NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139

Query: 6668 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 6721
             +   +   + +R +++E     W   LD     ED  + S +     SS   +  V + 
Sbjct: 140  RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199

Query: 6722 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6781
            E +  +      H   +  E   K Y+ L    R   + S   L+  +++  + W +   
Sbjct: 200  ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256

Query: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6841
            +++  L RL+  +     +++    ++ WL     +L      ++    E + V+  +  
Sbjct: 257  RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-----TNIEHFSECD-VQAKIKQ 310

Query: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6900
               F +E+    +    +++ G QL+ + + +D A +  EL  +     ++   +    +
Sbjct: 311  LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370

Query: 6901 KLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGYKAIHE 6948
            KL +L +            +L    A+S++       ++++  +   N+  S+      E
Sbjct: 371  KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430

Query: 6949 YLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 7002
               +     +D       +   L+ D  +     + S+D E +  D  DF  + GA+  S
Sbjct: 431  RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-GAVGLS 487

Query: 7003 WQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI------- 7051
              ++       ++L E  +++     S  E+ ++ L    +    +++Q   I       
Sbjct: 488  DVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 547

Query: 7052 -----GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSIVMSTL 7104
                          L +C    D +K  E ++++ E++  G   + + +   + ++    
Sbjct: 548  GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI---- 603

Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL--LTGS 7162
                  W  L       ++ +K  L +W       + I ++L +    L + +   L+  
Sbjct: 604  ----DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659

Query: 7163 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWN- 7221
            ++ +++Q+  L+ LQ  ++ ++  +    ++ +    +     +  L + L ++N RW+ 
Sbjct: 660  IQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718

Query: 7222 --NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD--IADD 7277
              +LLEE    LQ   AL+Q  Q + + S      ++  + R NE++   +N D  I  D
Sbjct: 719  VCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775

Query: 7278 EVATWIQDCNDLLK 7291
                 +Q  ++LL+
Sbjct: 776  HHKQLMQIKHELLE 789



 Score = 57.4 bits (137), Expect = 6e-07
 Identities = 171/974 (17%), Positives = 361/974 (37%), Gaps = 120/974 (12%)

Query: 3128 GELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQD 3187
            GE L+    + KA  I+ K+    + W++    +  +   L+   + ++  + +   ++ 
Sbjct: 2    GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61

Query: 3188 WLSKTEK-----MVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3242
            WL+  E      +V++S N   ++  K  EQQ+LQ  +E+       +  L E      +
Sbjct: 62   WLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120

Query: 3243 G---QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3299
                 A   S +     L  ++  +  ++ E+  +++       +F       +DW+  +
Sbjct: 121  ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180

Query: 3300 IHMLDSYCHPTSD---KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3356
                 +   P+S     +V      K EA      E   Q+++I  +   + +    +  
Sbjct: 181  ER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237

Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
             +++Q +      W +L         +L+  + +   ++        W+  M+  L   E
Sbjct: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297

Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM---TEHYVTQLELQDLQERY 3473
              H    D    + + K   +E+    + +E I  +G  +   +E     +  ++L E  
Sbjct: 298  --HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355

Query: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3533
            R  QE         +KL+RL       L   E  L   + +L+  + L  D H H+ +  
Sbjct: 356  RYCQEVFGRVERYHKKLIRL------PLPDDEHDLSDRELELEDSAAL-SDLHWHDRSAD 408

Query: 3534 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
             L   Q       +L   +   R         +    +++S+  +W    H    +R   
Sbjct: 409  SLLSPQPSSNLSLSLAQPLRSERSG-------RDTPASVDSIPLEW---DHDYDLSRDLE 458

Query: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
            + +   L   +++ Q   ++       +S     +S  A  ++  + +K    + +A   
Sbjct: 459  SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 518

Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
            ++ ++G    + LD+S                      Q+ +    +  +  +  E ++S
Sbjct: 519  QIRQLG----KALDDSR--------------------FQIQQTENIIRSKTPTGPELDTS 554

Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEK---GHSLLKSAREK 3770
               Y    G         ++ ID V         K LE  LK+ E+   G   L S   +
Sbjct: 555  YKGYMKLLG-------ECSSSIDSV---------KRLEHKLKEEEESLPGFVNLHSTETQ 598

Query: 3771 GERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ 3830
                +   E  +A+ L KE+                    +++ L   ++F+    ++  
Sbjct: 599  TAGVIDRWELLQAQALSKELR-------------------MKQNLQKWQQFNSDLNSIWA 639

Query: 3831 WIAEYQEILHVPE--EPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-- 3886
            W+ + +E L   +  E   ++   + Q+ K K LQ+ V   +  + S+        +   
Sbjct: 640  WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS 699

Query: 3887 VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946
             +   L+D++ Q+   +  +CS+ +E    L+  +   + ++ E+      +L+   R  
Sbjct: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-EMSHGLLLMLENIDRRK 758

Query: 3947 APDLLETSSLETITQQLAHHKAMME---EIAGFEDRLNNLQMKGDTLI--GQCADHLQAK 4001
               +   S+L+    Q  HHK +M+   E+   + R+ +LQ     L+   +  D L+AK
Sbjct: 759  NEIVPIDSNLDAEILQ-DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 817

Query: 4002 LKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEP 4061
             K     H+ G +     +     R  + LE  L    S+QD      +W SA + D   
Sbjct: 818  EK----VHVIGNR--LKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELDTSG 867

Query: 4062 SPQPPLSRAEAIKQ 4075
            S  P   R+   +Q
Sbjct: 868  SVSPTSGRSTPNRQ 881



 Score = 52.4 bits (124), Expect = 2e-05
 Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)

Query: 6984 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043
            S  S  ++   +LG +N  WQ L  L+  +++ L+  L +  + + N+  L+TW    E 
Sbjct: 9    SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68

Query: 7044 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 7094
             L +   +   +   +Q  L + Q+L       ++++EK    G+A + N  E       
Sbjct: 69   ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120

Query: 7095 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7148
                  +  SI  +T R L + W N+  M  + ++ ++     W      + +   +L  
Sbjct: 121  ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179

Query: 7149 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7207
            +  + + F   +G +  V + ++   +  Q  + +    L+       +L +E       
Sbjct: 180  SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238

Query: 7208 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 7235
            +L   + E N RW+NL + +   L+  K
Sbjct: 239  SLKQMVHEGNQRWDNLQKRVTSILRRLK 266



 Score = 52.4 bits (124), Expect = 2e-05
 Identities = 148/822 (18%), Positives = 313/822 (38%), Gaps = 82/822 (9%)

Query: 4314 VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK- 4372
            ++ +   +  RW  L DLI  +++     L  +  +      L  W    +  +A+ +  
Sbjct: 17   IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76

Query: 4373 QSPPPDMAQNLLMDHLAICSELEAKQM-------LLKSLIKDADRVMADLGLNERQVIQK 4425
             S   +  Q  L +   +  ++E           L + L+ D D    D    E   IQ+
Sbjct: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA---ECDSIQQ 133

Query: 4426 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4485
            A  +       +  +  +RR  + +      +FL    +    ++  ER   F     ++
Sbjct: 134  ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 193

Query: 4486 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4545
                 +++K  ++ Q  +     ++  +  Q R L +E        +   + E    +D+
Sbjct: 194  YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 253

Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKY 4605
            + ++ +  L+ L+  +  R+ F+   D    WL + D+    ++  +   SE   Q AK 
Sbjct: 254  LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL----QLTNIEHFSECDVQ-AKI 308

Query: 4606 QNILEQSPEY---ENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK-- 4660
            + +     E     N +  +   G+ ++     +D + + E+L+ L R    +    +  
Sbjct: 309  KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERY 368

Query: 4661 ----------DKFYKVQEAILARKEYASLIEL--------------TTQSLSELEAQFLR 4696
                      D  + + +  L  ++ A+L +L               + +LS   AQ LR
Sbjct: 369  HKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLR 428

Query: 4697 MSKVPTDL-AVEEALSLQ-----DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPD 4750
              +   D  A  +++ L+     D  R +   ++    + DE  Q  + F   G     D
Sbjct: 429  SERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSD 488

Query: 4751 KML-HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK----SVKEEQSKVN 4805
             M+      Y +L        + +++T+  +   E   +QL + L      +++ ++ + 
Sbjct: 489  VMIPESPEAYVKLTE------NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542

Query: 4806 EETLPAEE---KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQ 4862
             +T    E     K Y  L G    S   +KR+   L++    L         H  ++  
Sbjct: 543  SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTETQT 599

Query: 4863 GELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDL--N 4916
              +      +       E RM Q++     F ++++    WL   + EL     L+L  +
Sbjct: 600  AGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659

Query: 4917 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4976
            +Q I+ +I+K++  Q+ V     I+ +++    E FT+A    S DL+  L++++     
Sbjct: 660  IQTIELQIKKLKELQKAVDHRKAIILSINLCSPE-FTQADSKESRDLQDRLSQMNGRWDR 718

Query: 4977 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED----AQELLQLAGNGLDVESAEENL 5032
            +   L   +  L +   QCQ ++++       LE+      E++ +  N LD E  +++ 
Sbjct: 719  VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN-LDAEILQDHH 777

Query: 5033 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK 5074
            K  M+      +    +  L  +   L  L+   G + LE K
Sbjct: 778  KQLMQIKHELLESQLRVASLQDMSCQL--LVNAEGTDCLEAK 817



 Score = 52.4 bits (124), Expect = 2e-05
 Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)

Query: 6694 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 6753
            LD+ + ++ +   ++ S  P+     E +      + L     SS++  +   +++ ++ 
Sbjct: 527  LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583

Query: 6754 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6812
            + L   ++    E+Q   + + W L     +SKEL R++  L+ W ++ S+   +  WL 
Sbjct: 584  ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642

Query: 6813 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6872
              ++ LE    Q + +  +++ +   +    E  K VD + ++  S+     +  +    
Sbjct: 643  DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700

Query: 6873 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 6931
            ++  L+  LS+++ +W      + ++ E+   L  D L       E+   + LM EN+ +
Sbjct: 701  ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756

Query: 6932 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6989
            +  +   I +++  + + ++ ++    K ++   QL V  +     Q+    V ++ +D 
Sbjct: 757  RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813

Query: 6990 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 7042
             +  E++  +    ++L   V+  I+ LE LL    +  ++ Q L +W    E
Sbjct: 814  LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862



 Score = 52.0 bits (123), Expect = 3e-05
 Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)

Query: 5936 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 5995
            KLG +   W+ L ++I+ + + L E L   Q+   ++ S+ T +  IE   SE  +P   
Sbjct: 20   KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76

Query: 5996 PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 6048
                  E Q  ++E   LQ +I +  + +A      E++   C+  A  AE  ++Q    
Sbjct: 77   DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136

Query: 6049 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6108
             L  R   I   +  +R  +EE            +  Q++  +    + WL S++    T
Sbjct: 137  NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183

Query: 6109 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6168
            A  P    +       + +       Q    L++L + N+      + +  D A  L   
Sbjct: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243

Query: 6169 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 6225
            +         LQ+ +      ++    ++EE +     T    +  WL +     T    
Sbjct: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298

Query: 6226 ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 6281
                  Q+ ++Q K  +QE++   + +  + ++GE+++ +    + +        ++ +E
Sbjct: 299  FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350

Query: 6282 LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 6341
            L          D++R   + +        K L  +   + E  L  R   L     L   
Sbjct: 351  L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398

Query: 6342 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 6397
            D+   D+SA  SLL        + SS    +  Q +  E+   D  ++  +    W  D 
Sbjct: 399  DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451

Query: 6398 EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 6453
            +    + +A+   LP E E    +++   +    +S+ M           PE+ +    +
Sbjct: 452  DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501

Query: 6454 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 6511
             E+ +    G  S L+S + Q    + +   QI   +N +  K       D  Y    KL
Sbjct: 502  TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561

Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
                    +  I+++++ E  LKE +    G + L            +  + + + D ++
Sbjct: 562  LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607

Query: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 6628
             L     S+   + QNL    Q+   L  +   L   +E++   Q++ +S+  +  +L  
Sbjct: 608  LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667

Query: 6629 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6685
            K  +  Q    H   +IL+  L     + A  KE++   + ++Q +    R         
Sbjct: 668  KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721

Query: 6686 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 6732
             +LE W  L +D         E+S      LE ++     +  ++ N D   L D     
Sbjct: 722  -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780

Query: 6733 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 6789
              +K  L E Q ++  + D   +LL++     C + + +++ +G        ++S+ +  
Sbjct: 781  MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840

Query: 6790 LETILKHWTRYQSESADLIHWLQSAKDRLE 6819
            LE +L       S   DL  W  S+ D L+
Sbjct: 841  LEKLLD----VSSSQQDLSSW--SSADELD 864



 Score = 50.4 bits (119), Expect = 8e-05
 Identities = 141/728 (19%), Positives = 273/728 (37%), Gaps = 177/728 (24%)

Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQ 4918
            Q W    K +TS +       +  + Q  +F+T     L WL  +  +L+   +   +  
Sbjct: 249  QRWDNLQKRVTSIL----RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SEC 302

Query: 4919 DIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQ 4978
            D+Q +I++++  Q+E+  +   +  +  + ++   K++ L +A +E  L EL        
Sbjct: 303  DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY----- 357

Query: 4979 EALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF 5038
                       E++ + +RY++               L L  +  D+   E  L+     
Sbjct: 358  ---------CQEVFGRVERYHKKLIR-----------LPLPDDEHDLSDRELELEDS--- 394

Query: 5039 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5098
                    + L +LH    + D L+ P    +L   +A   LRS+R  RD+ A VD +  
Sbjct: 395  --------AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ-PLRSERSGRDTPASVDSI-- 443

Query: 5099 CTAQW-HDYQKARE-----------EVIELMNDTEKKLS---EFSLLKTSSSHEAEEKLS 5143
               +W HDY  +R+           E  E  +D +  L      S +    S EA  KL+
Sbjct: 444  -PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502

Query: 5144 E---------HKALVSVVNSFHEKIVALEEKASQLEKTGN-DASKATLSRSMTTVWQRWT 5193
            E         H AL S +    +   AL++   Q+++T N   SK      + T ++ + 
Sbjct: 503  ENAIKNTSGDHSALESQIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 559

Query: 5194 RLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEY 5253
            +L              + E +   + VK+    + + ++ LPG              +  
Sbjct: 560  KL--------------LGECSSSIDSVKRLEHKLKEEEESLPG-------------FVNL 592

Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT 5313
            H T                 QT  ++                      DR   +Q +  +
Sbjct: 593  HST---------------ETQTAGVI----------------------DRWELLQAQALS 615

Query: 5314 NGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5373
                +KQ L+  +   + +NS+  W+ +T+E           +LE+LQ L  E +   Q 
Sbjct: 616  KELRMKQNLQKWQQFNSDLNSIWAWLGDTEE-----------ELEQLQRL--ELSTDIQT 662

Query: 5374 IEKMAEEQKEKYLGLYTILPSELSLQLAE---VALDLKIRDQIQDKIKE----------- 5419
            IE   ++ KE    +       LS+ L        D K    +QD++ +           
Sbjct: 663  IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722

Query: 5420 VEQSKATSQELSRQIQ---KLAKDLTTILTKLKAKTDNVV--QAKTDQKVLGE---ELDG 5471
            +E+ +   Q+   Q Q   +++  L  +L  +  + + +V   +  D ++L +   +L  
Sbjct: 723  LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782

Query: 5472 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS-KLNQAASHLE 5530
               +L+E    V    + + QL   L    G      ++ +    NRL   L + + H++
Sbjct: 783  IKHELLESQLRVASLQDMSCQL---LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839

Query: 5531 EYNEMLEL 5538
            E  ++L++
Sbjct: 840  ELEKLLDV 847



 Score = 47.8 bits (112), Expect = 5e-04
 Identities = 152/743 (20%), Positives = 287/743 (38%), Gaps = 100/743 (13%)

Query: 1721 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780
            E L   + +     ++  L ++++RW+ L  +I  R+  L+  +   QQ D+ + S   W
Sbjct: 3    ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62

Query: 1781 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1840
            +    SEL              +     ++ E++ K  E Q LQ  + K  S G A  L+
Sbjct: 63   LAHIESELAK-----------PIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLN 110

Query: 1841 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1900
            L +    DC     +A    +  Q A  +L    ++  ++S    + R  +E T  + + 
Sbjct: 111  LCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQK 165

Query: 1901 ESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGE 1958
              D   +   D L++++   +   S   I + A+  LK   + QR    C    + +  +
Sbjct: 166  FLDDYSR-FEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 224

Query: 1959 VERIQNLLGTKQSEADALAVLKKAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQAL 2014
              R+      +++  D+   LK+   +   + + L K +  I  R       +E    A 
Sbjct: 225  YRRL-----ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 279

Query: 2015 QQRLRVFNQLEDELNSHEH-ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2073
               L    +++ +L + EH   C ++ K KQ+     AF  E+    N++E      ++L
Sbjct: 280  DSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQL 335

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKV---LENASSVIVTRTTIKDQEDL--KWAFSKH 2128
            I +++     +I+   E   L+    +V   +E     ++      D+ DL  +    + 
Sbjct: 336  IEKSEPLDAAIIE--EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 393

Query: 2129 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD----KW---LDV 2181
              A + +++  +  D+  S        L             D  ++VD    +W    D+
Sbjct: 394  SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 453

Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFE 2241
            S  LE  M R           L + DE      +   + A  +S++      E  +K  E
Sbjct: 454  SRDLESAMSR----------ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503

Query: 2242 SEVKNKALRLEELHSKVNDLKELTKNLETPP-DLQFIEADLMQKLEHAKEITEVAKGTLK 2300
            + +KN +     L S++   ++L K L+     +Q  E  +  K     E+    KG +K
Sbjct: 504  NAIKNTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMK 560

Query: 2301 DFTAQSTQVEKFINDITTWFTKVEESL---MNCAQNET-------------CEALKKVKD 2344
                 S+ ++  +  +     + EESL   +N    ET              +AL K   
Sbjct: 561  LLGECSSSIDS-VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619

Query: 2345 IQKELQS-QQSN---------ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS- 2393
            +++ LQ  QQ N         +  T+E L  L R   S +++++   +  L +  +AV  
Sbjct: 620  MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 679

Query: 2394 --------QLCSK--TQASLQES 2406
                     LCS   TQA  +ES
Sbjct: 680  RKAIILSINLCSPEFTQADSKES 702



 Score = 46.6 bits (109), Expect = 0.001
 Identities = 157/826 (19%), Positives = 311/826 (37%), Gaps = 150/826 (18%)

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
            M  ++A   H+  A+E+E K G++     HL           L L+  + +      +E 
Sbjct: 1    MGERLAKASHESKASEIEYKLGKVNDRWQHL-----------LDLIAARVKK----LKET 45

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               V++    +S L  +      L+ I  +L + +   +S N  E   I++ LN+  +  
Sbjct: 46   LVAVQQLDKNMSSLRTW------LAHIESELAKPI-VYDSCNSEE---IQRKLNEQQELQ 95

Query: 1917 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATA-DQLCGEVERIQNLLGTKQSEADA 1975
            + +E  +  +  +L+  +  L          C A A D  C  +++    L  +     A
Sbjct: 96   RDIEKHSTGVASVLNLCEVLLH--------DCDACATDAECDSIQQATRNLDRRWRNICA 147

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHE 2034
            +++                        + RLK E T +  Q+ L  +++ ED L S E  
Sbjct: 148  MSM------------------------ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 183

Query: 2035 LCW------LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ-GQCCGLIDL 2087
              +      +   AK+  +K  AF  +V   + +LE+     +RL  EN+    C L  +
Sbjct: 184  AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243

Query: 2088 MRE----YQNLKSAVSKVLENASSVIVTRTTIKDQED--LKWAFSKHETAKNKMNYKQKD 2141
            + E    + NL+  V+ +L      I  R   +   D  L W          +M+ +  +
Sbjct: 244  VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL--------TEMDLQLTN 295

Query: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK--------LEENMDRLR 2193
            +++F+        +  K    + SL    +E  + +   + EK        +EE +D LR
Sbjct: 296  IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355

Query: 2194 -----------------VSLSIWDDV--LSTRD-EIEG--------WSNNCV-----PQM 2220
                             + L + DD   LS R+ E+E         W +        PQ 
Sbjct: 356  RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 415

Query: 2221 AENIS-NLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKEL------TKNLETPPD 2273
            + N+S +L   LR+E   ++  + V +  L  +  +    DL+        +++ E   D
Sbjct: 416  SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 475

Query: 2274 LQFI--------EADLMQKLEHAKEITEVA-KGTLKDFTAQSTQVEKF--INDITTWFTK 2322
              F         +  + +  E   ++TE A K T  D +A  +Q+ +     D + +  +
Sbjct: 476  KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535

Query: 2323 VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESL 2378
              E+++        E     K   K L    S+I S +   + L  +  S      L S 
Sbjct: 536  QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 595

Query: 2379 GRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDR- 2435
                 G+I + E +       +  ++++L+K   F+  +     W LG      E   R 
Sbjct: 596  ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW-LGDTEEELEQLQRL 654

Query: 2436 --TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2493
              + D + +E ++  L+ +  +V   ++ + ++           SK+    +Q+++++ N
Sbjct: 655  ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE-SRDLQDRLSQMN 713

Query: 2494 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2539
              +        + +  LQD   +   F +    L L +  ++ R N
Sbjct: 714  GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759



 Score = 45.1 bits (105), Expect = 0.003
 Identities = 81/372 (21%), Positives = 159/372 (42%), Gaps = 52/372 (13%)

Query: 1344 RFETNK-ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE 1402
            RF+  + E ++R    TG   E   S+     L  E   + +  KR E       + +KE
Sbjct: 531  RFQIQQTENIIRSKTPTGP--ELDTSYKGYMKLLGECSSSIDSVKRLE-------HKLKE 581

Query: 1403 ASEIPLGPQNKQLLQQQAKSIKEQVKKLE-DTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1461
              E   G  N    + Q   + ++ + L+   L ++++  + ++ KW  F S+  ++  W
Sbjct: 582  EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ-KWQQFNSDLNSIWAW 640

Query: 1462 ITEKEKELNALE-----TSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT 1516
            + + E+EL  L+     T    +++QI ++K   + ++ + + I+ +   +  F Q   +
Sbjct: 641  LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADS 699

Query: 1517 GESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEE---NLRKIQQSVSEFED 1573
             ES  ++ +L+Q+    + +    +   G +   L Q Q F E    L  + +++   ++
Sbjct: 700  KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759

Query: 1574 KLAVPIKICSSATETYKVLQEHMDLC-----QALESLSSAITAFSASARKVVNRDSCVQE 1628
            ++ VPI     A    ++LQ+H         + LES     +    S + +VN +     
Sbjct: 760  EI-VPIDSNLDA----EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEG---- 810

Query: 1629 AAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDI--- 1685
                     D L  AKE+   + N L   + L KE+S  +  LE+     SS + D+   
Sbjct: 811  --------TDCL-EAKEKVHVIGNRL---KLLLKEVSRHIKELEK-LLDVSSSQQDLSSW 857

Query: 1686 -SADRVKVEGEL 1696
             SAD +   G +
Sbjct: 858  SSADELDTSGSV 869



 Score = 41.6 bits (96), Expect = 0.035
 Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)

Query: 578 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 628
           EE E++  F+N    ET       +W  L  +  S    +++ +  W ++ + + S+ AW
Sbjct: 581 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 640

Query: 629 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 674
           L D E+ L Q +  +               + L   +    A+  + N         D  
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700

Query: 675 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 712
            SRDL+ +L  +NGR          WR L  +     Q             + +DR K E
Sbjct: 701 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 760

Query: 713 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 752
                  L A   + H K    ++   +  +L +  L+D+
Sbjct: 761 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800



 Score = 40.0 bits (92), Expect = 0.10
 Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)

Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 7593
            ++W+ +  +A  +   +   +++WQ++      +  WL        ++  L +S  + ++
Sbjct: 604  DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663

Query: 7594 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7653
             + +++ + L   V  ++ +        IL++         ADS     LQ  L+++  +
Sbjct: 664  ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715

Query: 7654 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 7702
            W      LEE +  L   L   + + +   G+   LE +   K ++        ++ L D
Sbjct: 716  WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775

Query: 7703 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 7758
            HH++L   +    E +  V S  D   QL +  +      + + + ++  R++LL     
Sbjct: 776  HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835

Query: 7759 RQWEELCHQLSLRRQQIGERLNEWAVFSE 7787
            R  +EL   L +   Q  + L+ W+   E
Sbjct: 836  RHIKELEKLLDVSSSQ--QDLSSWSSADE 862



 Score = 39.3 bits (90), Expect = 0.17
 Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)

Query: 7003 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 7062
            W++LQ     K   ++  L+ W ++ +++  +  W    E+ L+Q  R+     +Q    
Sbjct: 606  WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665

Query: 7063 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 7120
              + L++L KA +     I    L   +  + D   S  +   L ++   W  +  ++ +
Sbjct: 666  QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725

Query: 7121 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 7174
             + LL+  L Q       F +++  L+    ++ R +     +  +L+A  +Q     L 
Sbjct: 726  WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781

Query: 7175 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7234
             ++ +L + +  +     ++ QLL              +  +  R   LL+E++  ++  
Sbjct: 782  QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841

Query: 7235 KALLQLWQRYKDYS 7248
            + LL +    +D S
Sbjct: 842  EKLLDVSSSQQDLS 855



 Score = 38.9 bits (89), Expect = 0.23
 Identities = 53/276 (19%), Positives = 120/276 (43%), Gaps = 25/276 (9%)

Query: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDT---ANHGEVK 1164
            L+A   S   ++ ++  KW+ + S  +   +W+   E +L+ ++   + T       ++K
Sbjct: 609  LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 668

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
            + ++E++  V  R   +  +       T+  S+ E++   D L++++  +  + +LL E 
Sbjct: 669  K-LKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEW 726

Query: 1225 EKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTK 1283
              +L +    C  + E+    L  L    + +  +  +I+  ++  +A+ L  HH+Q  +
Sbjct: 727  RGLLQDALMQCQGFHEMSHGLLLML----ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782

Query: 1284 RISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ--ERRIQVTLRK 1341
                    ++ ++ ++Q     L D   + L   E T D LE   +      R+++ L++
Sbjct: 783  --------IKHELLESQLRVASLQDMSCQLLVNAEGT-DCLEAKEKVHVIGNRLKLLLKE 833

Query: 1342 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSS 1377
              R     E     L    SS +   S+SS + L +
Sbjct: 834  VSRHIKELEK----LLDVSSSQQDLSSWSSADELDT 865



 Score = 37.0 bits (84), Expect = 0.87
 Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)

Query: 7411 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 7470
            +RL +  +    ++ E K +  +N  W  +      R  KL+  L+  Q   +   +   
Sbjct: 3    ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61

Query: 7471 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 7527
            +L   E +LA  I   S N + +  +    +  Q ++      + S++   + LL     
Sbjct: 62   WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121

Query: 7528 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 7583
                 + D        L  +W+ +   + +RR  I+   R WQ++ +   +   WL    
Sbjct: 122  CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179

Query: 7584 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 7639
                    + P       T+  E   K + F RQ    +  +E      ++L     + +
Sbjct: 180  ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236

Query: 7640 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7699
              +L+  + E  ++W +   R+    ++L   +   E+ E      L  L     +L+  
Sbjct: 237  ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296

Query: 7700 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  ++ A+  + K  +  +    + + Q+    + L       D +I+ E ++ L+R
Sbjct: 297  EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356

Query: 7760 QWEEL 7764
              +E+
Sbjct: 357  YCQEV 361



 Score = 37.0 bits (84), Expect = 0.87
 Identities = 59/369 (15%), Positives = 151/369 (40%), Gaps = 43/369 (11%)

Query: 579 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWL--------- 629
           +A  +   + +   +W++L   + +    L+E +    +    ++SL+ WL         
Sbjct: 13  KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72

Query: 630 ---------EDAEKMLNQSENAKKDFFRNLPHWIQQHT----AMNDAGNFLIETCDEMVS 676
                    E+ ++ LN+ +  ++D        I++H+    ++ +    L+  CD   +
Sbjct: 73  PIVYDSCNSEEIQRKLNEQQELQRD--------IEKHSTGVASVLNLCEVLLHDCDACAT 124

Query: 677 ----RDLKQQLLLLNGRWREL-FMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKL 731
                 ++Q    L+ RWR +  M +++  + +E  R+ +++ D       +   + +  
Sbjct: 125 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184

Query: 732 SEPLE--VSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
           + P    V +   K  ++  E  +++V     Q ++I K    + +E+  +    +   +
Sbjct: 185 AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV 244

Query: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
            +  ++   +++  + +L   +  +   EE E    S    L +++  +T +E  ++   
Sbjct: 245 HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDV 304

Query: 850 LFKQKHQELLACQE----NCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 905
             + K ++L A Q+    N  K   +I +G Q ++K   L   +   +   L+R   ++ 
Sbjct: 305 --QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362

Query: 906 VAFQSMVKK 914
              +   KK
Sbjct: 363 GRVERYHKK 371



 Score = 36.2 bits (82), Expect = 1.5
 Identities = 139/775 (17%), Positives = 298/775 (38%), Gaps = 106/775 (13%)

Query: 1402 EASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1459
            +ASEI   LG  N +  Q     I  +VKKL++TL   +   ++ K        N  +L 
Sbjct: 13   KASEIEYKLGKVNDRW-QHLLDLIAARVKKLKETL---VAVQQLDK--------NMSSLR 60

Query: 1460 VWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS-IVGLEEEAQSFAQFVTTGE 1518
             W+   E EL       S    +I +     QE++  +     G+          +   +
Sbjct: 61   TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120

Query: 1519 SARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLR---KIQQSVSEFEDKL 1575
            +    A+   I++    L    + +       + ++ K EE  R   K     S FED L
Sbjct: 121  ACATDAECDSIQQATRNLDRRWRNICAM---SMERRLKIEETWRLWQKFLDDYSRFEDWL 177

Query: 1576 AVPIKIC---SSATETYKVLQEHMDLCQALE-SLSSAITAFSASARKV--VNRDSCVQEA 1629
                +     SS+   Y V +E +   +A +  +   +T      ++   + R++    A
Sbjct: 178  KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237

Query: 1630 AALQQ-------QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1682
             +L+Q       +++++ +R       L++ +   +  E    S L WL   + + ++ E
Sbjct: 238  CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297

Query: 1683 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1742
                 D   V+ +++ ++A Q E+    +   +++   E L   +   D  +++   E+L
Sbjct: 298  HFSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---EEL 351

Query: 1743 DERWRDLPQIINKRINFLQSVVA------EHQQFDELL-------LSFSVWIKLFLSEL- 1788
            DE  R   ++  +   + + ++       EH   D  L       LS   W       L 
Sbjct: 352  DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL 411

Query: 1789 --QTTSEISIMDHQVALTRH--KDHAAEVES----------KKGELQSLQGH-LAKLGSL 1833
              Q +S +S+   Q   +    +D  A V+S             +L+S     L      
Sbjct: 412  SPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471

Query: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1893
            G+ +    L+G       +  E+ +   +  L  + +      H++L   +RQL + ++ 
Sbjct: 472  GQDDKDFYLRGAVGLSDVMIPESPEAYVK--LTENAIKNTSGDHSALESQIRQLGKALDD 529

Query: 1894 TNSMNKNESDLIEK------DLNDALQN-AKALESAAVSLDGILSKAQYHLK-------- 1938
            +    +   ++I        +L+ + +   K L   + S+D +  + ++ LK        
Sbjct: 530  SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV-KRLEHKLKEEEESLPG 588

Query: 1939 ---IGSSEQRTSC------RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEE 1989
               + S+E +T+          A  L  E+   QNL   +Q  +D  ++   A+    EE
Sbjct: 589  FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW--AWLGDTEE 646

Query: 1990 LLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2049
             L+ ++ +E  TD         Q ++ +++   +L+  ++  +  +  +   + +  Q D
Sbjct: 647  ELEQLQRLELSTDI--------QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698

Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN 2104
               + ++   ++++   WD    L+ E +G     +   + +  +   +  +LEN
Sbjct: 699  SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 753



 Score = 35.4 bits (80), Expect = 2.5
 Identities = 53/282 (18%), Positives = 123/282 (43%), Gaps = 29/282 (10%)

Query: 2704 QTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQ 2761
            +TQ   + + W  + + ++  +  ++  + +W  +    N +  W+   ++++E    L+
Sbjct: 596  ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 655

Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQF 2821
                ++   + +  L+  L +A DH +A+  +++ +    E T+ +S +    ++  +Q 
Sbjct: 656  LSTDIQTIELQIKKLKE-LQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQM 712

Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS------DMSGDSSA 2875
            N         + +   +++D LM     HE +  L    E + R        D + D+  
Sbjct: 713  NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772

Query: 2876 TQ---KKLSKIK-ELIDSREIGASRLSRVESLAPEVKQNTTASGC----ELMHTEMQALR 2927
             Q   K+L +IK EL++S+     R++ ++ ++ ++  N   + C    E +H     L+
Sbjct: 773  LQDHHKQLMQIKHELLESQ----LRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828

Query: 2928 ADWKQWEDSVFQTQSCLENLVSQMALS------EQEFSGQVA 2963
               K+    + + +  L+   SQ  LS      E + SG V+
Sbjct: 829  LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVS 870


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  372 bits (955), Expect = e-102
 Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)

Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 1314 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1370

Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1371 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1429

Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
                T    +V    +Y+   G S +R       +SL  E ++  E +K  +        
Sbjct: 1430 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1487

Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
             +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D   +
Sbjct: 1488 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1541

Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
              E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L  +
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
             ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K   
Sbjct: 1602 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1658

Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
                 EDK  +  K+  +     K  Q ++   Q+ + L   +T                
Sbjct: 1659 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1700

Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
                A++++ E +  +++ +E +T +ENLL     ++K+           +    T  + 
Sbjct: 1701 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1756

Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
            G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+  
Sbjct: 1757 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1816

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
            +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD  
Sbjct: 1817 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1874

Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
               F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+   
Sbjct: 1875 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1934

Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
                        K+ +     ++      A D F+       V+      L  L +  Q 
Sbjct: 1935 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1991

Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
            +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ + 
Sbjct: 1992 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2050

Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
              A+  L    S    +   + T D + G  E +   +  +  +         + QD  +
Sbjct: 2051 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2110

Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  + 
Sbjct: 2111 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2170

Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
             D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  + 
Sbjct: 2171 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2230

Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
             + T   +  KD  +L               Y Q+    F    KHL    S LK+I S 
Sbjct: 2231 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2276

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
                + +D    ++K  ++S+K +E  D ++      + V S +++++ +        + 
Sbjct: 2277 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2330

Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
            + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   + 
Sbjct: 2331 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2389

Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
            TP                AK I  V  G  + +    +T  E+F  +     T +++ + 
Sbjct: 2390 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2431

Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
            + +       L  +KD   EL ++ S +   QE  +++ +        +     T     
Sbjct: 2432 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2490

Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
             EAV     KTQ    +S E    +++ + QE                     L+ KL +
Sbjct: 2491 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2524

Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
            L                + +   T  A   KQ+       +T+ + ++Q   +  +  +Q
Sbjct: 2525 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2561

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
             L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E  
Sbjct: 2562 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2619

Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
              +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A+ 
Sbjct: 2620 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2679

Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
            +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K+ 
Sbjct: 2680 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2739

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
             A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +  
Sbjct: 2740 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2798

Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
               + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        + 
Sbjct: 2799 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2849

Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
            IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + V 
Sbjct: 2850 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2908

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
                W+                    Q  L +IK  +D  E G + +++++SL  E+ Q+
Sbjct: 2909 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2950

Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
                  EL++    +L +  +  ++ V      L   V  +          +  + Q  +
Sbjct: 2951 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3008

Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
            +F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R +
Sbjct: 3009 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3068

Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
            +DL   +    G          + +E++ L  Q  + C   E  LQ         +    
Sbjct: 3069 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3128

Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
             F +F   L +          + +    +   L+K++  ++ ++N      MML+  E  
Sbjct: 3129 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3188

Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
              L+      GI+  + A  +           +E  +E    ++++F    +     L K
Sbjct: 3189 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3242

Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
             E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    +A
Sbjct: 3243 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3296

Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
            +KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D   
Sbjct: 3297 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3356

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
            ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I +
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3416

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
            QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E    +
Sbjct: 3417 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3476

Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
                   + + K L +++++++  L      G  +       +  + Q +L   Q  Y  
Sbjct: 3477 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3536

Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
            IQE++       ++ +   + +  D      WL +  +KL + SV +         ++ L
Sbjct: 3537 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3596

Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
            R LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++  
Sbjct: 3597 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3654

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
                  +   R +    +++  WL   E E +S  T+        + Q+   ++KK  + 
Sbjct: 3655 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3714

Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
              A  D + EV +   E++      +R G +    +   RY+ +   + ++++ ++  I 
Sbjct: 3715 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3771

Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
              ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     +   
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3826

Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
            ++    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +F 
Sbjct: 3827 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3886

Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
            +  + L  W+ E Q I+     P +E    + Q  +++ L++ +  H+P +  + + G  
Sbjct: 3887 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3946

Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
            LLEL   +  ++++K     + Y  +    K+   +L+  +     ++ ++ ++ + L +
Sbjct: 3947 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4006

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
            +  RL  P  + ++ +E I +Q++ +K +  ++   +     L+ +G+ +I +       
Sbjct: 4007 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4065

Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
              A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T++
Sbjct: 4066 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4118

Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
              Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +  
Sbjct: 4119 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4176

Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
               VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L +M
Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236

Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
                ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   + L
Sbjct: 4237 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4294

Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
             +    W  L  +  N   + E  L     +   ++ +  +L               +  
Sbjct: 4295 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4354

Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
            A+ +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  + 
Sbjct: 4355 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4414

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            +  +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H+ 
Sbjct: 4415 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4474

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
            +C+  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  L 
Sbjct: 4475 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4534

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
            +AL+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++ +
Sbjct: 4535 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4594

Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
            +  L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F E
Sbjct: 4595 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4654

Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
             + K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+++
Sbjct: 4655 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714

Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     L 
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4774

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
             +E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R   
Sbjct: 4775 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4832

Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
              W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+  
Sbjct: 4833 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4889

Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
                LP +E      +  +      L++    L + T   + +     P +    +H I 
Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4949

Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
              +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + + 
Sbjct: 4950 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 5004

Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
            I +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD     
Sbjct: 5005 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5063

Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
              R   ++L    SQ Q             ++ QV+  A       ND L+  +EL + A
Sbjct: 5064 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5123

Query: 5020 GNGLDV 5025
                D+
Sbjct: 5124 NFDFDI 5129



 Score =  340 bits (873), Expect = 3e-92
 Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)

Query: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1198

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
            K++ + L   +L     AE+ +K +  K    E+V   +  ++N +S +        E  
Sbjct: 1199 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1255

Query: 551  KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
            + F   E        ++ ++ K   E  +  D   E+A+ +++       +W+N+ V++ 
Sbjct: 1256 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1308

Query: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
            +    LE +  +   Y +T   L  W++  E        NQ EN+K    + N    +  
Sbjct: 1309 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1368

Query: 657  HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
               M  +     +   E  S  +K   L       +++ + +     VK+       D +
Sbjct: 1369 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1425

Query: 710  KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
             +E+ D     +A  T     +++ ++ +  ++K L ++ + +E+       + K + K 
Sbjct: 1426 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1481

Query: 770  AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
               I+K  +  ++ GK  F+      E+++  KE  S  L   Q  L             
Sbjct: 1482 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1541

Query: 819  ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
            ELEKQ+ +  +S   +        +E+Q+S   K + + +   Q+  K+ L         
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601

Query: 871  ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
                        +I  G+  ++K+ +    L+  D     + +A++    ++ +K+ G+ 
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1660

Query: 919  -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
                 K  +E           +L  K E+S+ EL+KV+  A +E  E+    ++L    T
Sbjct: 1661 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1720

Query: 965  EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
            +  + LD      +L   D+ ++    + +Q +++     H Q  D       + E   +
Sbjct: 1721 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1772

Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
            LL   +D +    + + +E   +  ++ K       EKII +H+ V  + +    L EK+
Sbjct: 1773 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1824

Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
             Q +  EE   K  ++  +++        L E    +  T+  L E+ +K+  DYT    
Sbjct: 1825 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1876

Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
            EF  W+  +E +L+ ++  A D      ++KR      + ++ +G+      S  +VL  
Sbjct: 1877 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1936

Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
              S         + +    +   KL  +     +L S+   + +N  D V   +  +++ 
Sbjct: 1937 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1996

Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
              L++G +  +  A K L +E +    + L    ++TK +  +    Q  + + ++    
Sbjct: 1997 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2055

Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
            L D     L     ++ TLD        L +S   +  ++Q+TL +    +   + ++ +
Sbjct: 2056 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2115

Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
            +    SS +      L+ ++L+  +S  +   ++ + R  SI    E  VK+  E    P
Sbjct: 2116 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2173

Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
                 LQ + K +  +  +     +E +  ME +KTK + F +  E L  ++  K + L 
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2233

Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
             ++     +      ++ +  E       +  L    +  +      + A +  K   + 
Sbjct: 2234 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2293

Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
            +  +E+ +  +  +  +     Q   F+  ++ ++  + E                    
Sbjct: 2294 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2353

Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
             ED   +  K      E  KV    + LC  + ++++   A +A  S   V+N +     
Sbjct: 2354 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2413

Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
                       S  ++   +   YED+    K++   L   L+  Q+ ++E S+ + WL+
Sbjct: 2414 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2473

Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
            +    A+  +      D  A + +VE        L+  V        KL +L E      
Sbjct: 2474 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2533

Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
                 K M   L ++D +W++L Q+   R   L+       QF  +      W+   +L 
Sbjct: 2534 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2590

Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
            +S L   S           ++ I+  + A TR   +         + S+ GE  SL+G +
Sbjct: 2591 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2648

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
             K       +    L G+  D     ++A     + Q  L  L+                
Sbjct: 2649 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2708

Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
                    + L++   +   ++Q ++ ++   ++ ++ S L++++   A + ++ LE   
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2767

Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
             S   +  KA+ H+     +   S  A++ Q        Q  L TK+ E +        L
Sbjct: 2768 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2822

Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
             VL+   +D K+  + L +   + E+T  E      + +   + ALQ +L       D  
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2882

Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
            N      E++L    +KA +  ++     P +D+  N LE      D  +        + 
Sbjct: 2883 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2942

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
            + +   Q  G+++L+    N   +V +     V +   S+I     + +Q        E+
Sbjct: 2943 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3002

Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
            +   F + +     +K ++   ++ LD   S G    S                     +
Sbjct: 3003 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3062

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
            L K  + D  +  +D + T D  L V E + +    L   +      L T+ +  G   N
Sbjct: 3063 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3121

Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
             + +M    +  D+ L       R  E L++ +  +K    +LE L +  ++  +  K +
Sbjct: 3122 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3181

Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
                ET PDL  I+ DL    +   ++ + A+       A+  QVE  I  +  +++K++
Sbjct: 3182 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3234

Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
            E    L    ++E  +             L   K  QKE    LQ +Q +++   + L  
Sbjct: 3235 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3294

Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
               K  S   + L   +  +  + + +++  ++  A LQE+L     F ++++    W +
Sbjct: 3295 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3352

Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
              +         + + KV++A++ + + +   + D +S ++ + +EG+ +          
Sbjct: 3353 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412

Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
             I +Q++  +  ++A L +     + L+  +     F +    LN W+  +E+R  N E 
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472

Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
            +G     + E+       ++++      L + ++  +SL  LS R      E     Q  
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3526

Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
               SQ+   +  +   +  +    Q AL   +   E    +  W+  + D+L+       
Sbjct: 3527 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3584

Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
            S + L K+ S++    +DILL K      ++ A+  G + L+ +  +   +IQ +LE +K
Sbjct: 3585 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3640

Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
              + DI   S     TLE  +           +L  W++ V+ ++          E   Q
Sbjct: 3641 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3700

Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
             Q   KE      + +++L    + + AL  L+  ++RE  EK   E            +
Sbjct: 3701 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3751

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            +  +     +K+ +++  +     +  A      W+   +++L    D+  +   T  +L
Sbjct: 3752 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3811

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
               K    + EI   +         ++  +   SG ++M    +  +   K+  D V + 
Sbjct: 3812 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3860

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
               +  + S+  L  +     V Q  +  E+    L      ++ L     + E + +  
Sbjct: 3861 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3920

Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
             + +++ + + + +P  + +     +L   S       G+   + ++Y   + L  Q  +
Sbjct: 3921 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3974

Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
              + +   L +   ++   F   +     +  +  +  +    +S  ++KI+E +SE++N
Sbjct: 3975 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4033

Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
                +  +    E L      ++ +         AK +Q K+      W+N H+ + ++E
Sbjct: 4034 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093

Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
            + L ++    + F      +   +  T+  + +  +   D    +++Q+  +++ EEI  
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4153

Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
             + +L+ +     +L    G+      +  + +L+S + +L+   K+++ +L+  +    
Sbjct: 4154 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4213

Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
            Q+  G++ + DW+  A   L S     +D   +  +  +L+   S   +++I+M+ +  +
Sbjct: 4214 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4273

Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
             E +L+  + E    T+Q  L  +K +W SL    I  + +LEGAL     +Q  + +  
Sbjct: 4274 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4333

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
             W+   E  L+E +    + +     L K  +L  +VL++ S +E +   G  + E    
Sbjct: 4334 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4393

Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
                  Q +L+ L +R++ + E+ ++   + +  +R  + +  +++  + WL   +  L 
Sbjct: 4394 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4453

Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
                L G   T +  L    E+       +    S++   + ++      AE   D+ + 
Sbjct: 4454 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4513

Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
            +L++ W++ + +L+E +T+    +N         Q    WL  AE+ ++  +R      T
Sbjct: 4514 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4573

Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
               Q+ + K +  EV ++R+++ E+      +   S     +  +     + SR++ ++ 
Sbjct: 4574 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4633

Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
            +++E+ + L++  +  ++   + S   +W   + K+  +   +A   DK+ T     +L 
Sbjct: 4634 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4688

Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
              +   K +   HS+  +    G R++K       + L+  + D + +L++   T+    
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4745

Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
             +    LE+ L  + +F+D  +AL  W+   +  L   +    ++      +  +K+ Q+
Sbjct: 4746 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4805

Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
             +     SV++++     L+E  +D +  +K ++ +L + ++ +C++       LEA ++
Sbjct: 4806 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4865

Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
              E+++S +  + +WL +    L    V PD  +  +L T+  Q   HK  M+++     
Sbjct: 4866 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4920

Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
             LN     GDT++  C       +K  +       +  +  + + A++  Q L   L   
Sbjct: 4921 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4976

Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
            +++Q+ L+   AWL   +  L    +  +      ++++  +AL  + +T+++
Sbjct: 4977 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 5024



 Score =  320 bits (819), Expect = 5e-86
 Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
            HQQ    + ++  D  +   ++Q   G    +  +E+   +     L +S ER+E+   V
Sbjct: 1034 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1093

Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
                   +R    R E  ++ ++R +    +    HE     +  E L  ELE+ K+   
Sbjct: 1094 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1150

Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
               +I  + E    +A+     P  +  L    +++  QV  +  T  + +KT+ +V   
Sbjct: 1151 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1209

Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
                 +  +     + E+E    A+    + ++  IS +K    E++ K      LE+E 
Sbjct: 1210 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1265

Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
            Q     S   F T  E                        +I  +L  +   G+ L+ + 
Sbjct: 1266 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1325

Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
                 L+  I       Q+ E   RKIQ++  E    LA  +          ++ Q  MD
Sbjct: 1326 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1378

Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
             CQ   E  S+ +  +            +  +  V R      A  + Q++ D+    + 
Sbjct: 1379 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1434

Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
            R TAL  L+  +        +RLE+E  S     +    KA   +  +S   +   + E 
Sbjct: 1435 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1494

Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
                    + +S     +K  QL E+L ++         +L L +  ++  D      + 
Sbjct: 1495 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1539

Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
             N L+  V   Q+   LL S S+     L E QT+ ++ + + ++   R +++  +++  
Sbjct: 1540 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1595

Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
               L   +  L     +G  E   +  G  E            +++ Q     L + +Q 
Sbjct: 1596 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1638

Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
             A +L+ +++     + E    +++ +  LIE+ LN+A    + L    E +   LD ++
Sbjct: 1639 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1698

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
            + A         ++ T   A   QL     +I+NLL                        
Sbjct: 1699 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1750

Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
            GT   E D     K A  ++ E    LL++  D +  T +E L +  ++   Q  ++ +Q
Sbjct: 1751 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1806

Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
             +  + + +     L+ + + ++ ++     ++ + +  L+V ++          +L H 
Sbjct: 1807 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1863

Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
             Q +         E+++      + LEN    A  +    T +K Q+        H+   
Sbjct: 1864 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1921

Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
                    DL   T  G  +L   K     D   V T          +V  KL+   DR 
Sbjct: 1922 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1968

Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
            R   S  +       D++      E  S   +  +    +    HL            R 
Sbjct: 1969 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2028

Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
             E  K  + ++ ++ + +E+L      L +   +L     D+Q    D++ + E   +  
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2088

Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
                  L+    +S  V+  ++++  W   VE SL    Q   N T   + + K   +++
Sbjct: 2089 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2148

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            ++  +QS+I++  E +         +   SL   M  L  +    S    +T A ++E  
Sbjct: 2149 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2208

Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
             K    E++ E  + FL  K  A    D  G   V E   + +Q       + +  L+ +
Sbjct: 2209 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2266

Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
                + + +H      + + E+    +++F+       + K+A+  C  +L +F+   + 
Sbjct: 2267 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2326

Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
            L  WI E  ++       F  E+LG+S +   +       K  E+ KV    + L  L++
Sbjct: 2327 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386

Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
            A     +++  +   G +L+ EG     E    ++ LTS           +++L  + K+
Sbjct: 2387 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2446

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
            K+      L + +  +E   +M  W++ +       + T    DT   +    Q+     
Sbjct: 2447 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2503

Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
             E E+K N+  + + +  L    +E     +       L  +   W ++   ++  Q  L
Sbjct: 2504 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2563

Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
            E   +    +   + QL+QW+   +  +    PL   P +         +Q +L E    
Sbjct: 2564 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2621

Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
                 +L A  + +  +  ED S +   +E+L   TQ  D +T    ++   +++ +   
Sbjct: 2622 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2681

Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
              Y   +   +D L     +L     +S    A  ++L    K+K+ I  + ++I  ++ 
Sbjct: 2682 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2740

Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
            +  E L+  VK+       E +  E+ + L    K ++D   + ++ +++L S  A S Q
Sbjct: 2741 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2793

Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
                     +Q    F A L T  ++          L +LE    D +        Q  +
Sbjct: 2794 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2845

Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
                 AE     LK+Q +E       L+T         K+            + +E  L+
Sbjct: 2846 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2894

Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
            +   KA +  +Q      W+   +    +   C D  +  + ++   SLQK + +     
Sbjct: 2895 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2954

Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
            E   +  N +LS  E+   ++T E    IQ KV    E        LH K+  LEN+  +
Sbjct: 2955 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 3006

Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
             K+F EVS E  +      E++ +H+S   L       +    LQ+  + +   + Q++ 
Sbjct: 3007 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3063

Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
             K  AQ L    + SK       +V  ++ ++  LS    EK S L+  +     F   I
Sbjct: 3064 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123

Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
            +E+     +    LDS      D   L  +         KLEAL++         KM++ 
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3183

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
              E     TSP+ +  I++ L+++      LL      + Q+EG + +   +   +++FS
Sbjct: 3184 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3237

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
              +   E +         E       L   K+   EE+       + +   G G+     
Sbjct: 3238 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3297

Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
              T     + +L D+  R++ + ++  +   + ++ +     +Q  L++   W+   +E 
Sbjct: 3298 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3357

Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
            +        +    +  +++ + LQ    + ++ +  +    E +  +  P  + + L+ 
Sbjct: 3358 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3417

Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
            L      W+A  ++      Q   +    +   +  + ++EWL T E+++       +  
Sbjct: 3418 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3477

Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
            +  E Q+ Q K   +++  +   + +  +  Q +       D+  V S++        + 
Sbjct: 3478 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3537

Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
             + +     LL Q L   K F E+E++ +           +W    H     ++  +   
Sbjct: 3538 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3584

Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
             T  + K+   L VL +D+      +  A   G   +K     E   ++ ++     + K
Sbjct: 3585 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3644

Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
            ++T        TLE+ L LA+      + L  W+ + +  L   E   ++  E      +
Sbjct: 3645 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3704

Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
             K L++   +++  + S+ E   ALLELV       L+  + +    Y+ +     + V 
Sbjct: 3705 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3764

Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
             ++A +   + ++        W+ +   +L++   +     +T + QL   K    EI  
Sbjct: 3765 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3823

Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
             +D +++L   G  ++  C++  +  +K+ +   L+    +Y  IC      Y  LE   
Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3879

Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
                   +T ++   WL+  Q  +   P P L       + +  R  QE+ R   +L+  
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3932

Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
                 +   KT  + ++ +     +I++K V A  L   + +IK    +  + L +A   
Sbjct: 3933 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 3989

Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
                    DQ L++++R    L        E+   +  +S+ K+    ++  Q    T+ 
Sbjct: 3990 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4049

Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
            ++  ++  +    +     K +    DQ + +    + L  +RE    D+    +   C 
Sbjct: 4050 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4109

Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
            ++  +   K T ++      D E   +    +K+   A +  +  I+ L+++        
Sbjct: 4110 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4165

Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
             ++I      DK +VK+    L   W  L    K +I      ++     Q   Q + +W
Sbjct: 4166 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4225

Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
             +     +A                E LKQ       Q + M+ L   +EL     LLK 
Sbjct: 4226 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4280

Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
            + +++D+            +Q  L + +   + L + +  R+  L  AL    QF  A+ 
Sbjct: 4281 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4330

Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
            +  + +   E  +  ++ +   P  +  ++      Q  +  +Q+ V  +   G +L++ 
Sbjct: 4331 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4390

Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
               +E S +  KL+ L   + +VL+K   R Q+L+  L   K F  + +    WL   + 
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450

Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
                   L         QL  +  +       E    +L + GQ +L    +   + + +
Sbjct: 4451 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4510

Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
             +N L  ++  +     ++  K++EA+    E+ + ++     L++ E Q L ++  P+ 
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4568

Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
            L ++  L   D  +   +EV    E + EL++     +   Q        + ++ + + +
Sbjct: 4569 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628

Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
             ++ ++  +R   L+D    A Q HE   K+ + LE   KS+  E    N+    +T  A
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688

Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
            + K     L   HS+  +   +G  LK  T   +D           K    +   + +  
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4739

Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
             +     E   + E  ++ S  F   +   +DWL RV+ +L+   PV+ D++L  +   I
Sbjct: 4740 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4797

Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
               +  Q+E+      + AL    +E    +++  S+ ++  + ELS     +     ++
Sbjct: 4798 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4856

Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
            Q  L     Q + ++ V  A  +WL +A++ L+  G   D E A   L   H EF    +
Sbjct: 4857 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4916

Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
            +  + L +  ++  T+  +  P             +   E+ +A  +   QR++      
Sbjct: 4917 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4976

Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
             A+ +LL+   A  QW +     K +E + + + + +  ++E   F    T    + ++ 
Sbjct: 4977 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036

Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
               +K   +  +S    I  L++         AS L  +G+     T +  +  +  +W 
Sbjct: 5037 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5096

Query: 5194 RLRAVAQDQEKILEDAVD 5211
            ++  +A ++ + L DA+D
Sbjct: 5097 QVWLLALERRRKLNDALD 5114



 Score =  318 bits (815), Expect = 1e-85
 Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)

Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
            V+    W+D M+  L+ +E   ++L    + L   K ++  +  + S L+  ++    MT
Sbjct: 637  VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 695

Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
                  L+L   ++ +R   + AK   T   +   L  LH    R      +WL +++E+
Sbjct: 696  ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 750

Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
               Y   E + +       H   +R+L + + +    Q +   +L       P+ +    
Sbjct: 751  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 807

Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
             RA    +  W     Q  +  + E    F              ++  ++L+  ++ +  
Sbjct: 808  YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 859

Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
            +    R S+    E  + +  +  EE+  Y+  +  +  +A+ I+     NS    + + 
Sbjct: 860  KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 919

Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
              +    Y+ + + + +  + +        + ++ S   +E+ + S        +K   +
Sbjct: 920  PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 979

Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
            +A +I++       + + TL     + +K +   H L+      R     ++K +  GE 
Sbjct: 980  LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1034

Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
            ++    L+    D +E  +E       +   LEK +++ K++             YQE+L
Sbjct: 1035 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1081

Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
               E  + E       +S+ ++++  + + E   ++ +R      +  E++  + +   L
Sbjct: 1082 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1141

Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
            K ++++L+ D   + +  +E  FS  A         SEL  V + + Q   MS   +  D
Sbjct: 1142 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1198

Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
             L+T +L     Q A      +   + EE A   D+ NN++    TL  Q    +  K +
Sbjct: 1199 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1255

Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
            Q  HA L+       AI     + Y+  + +   H  + D L   + W +  VQ D    
Sbjct: 1256 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1310

Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
                L   E I K +K++R        ++             V+TT + IQ+ +    +T
Sbjct: 1311 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1355

Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
            +  +L Q + L     EI+  +S++    + A+Q    +K    EL+    + MV   + 
Sbjct: 1356 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1410

Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
               K +  Q+S + II++   L  +     +  +  L  Q++     S     + E+ L+
Sbjct: 1411 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1465

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
              +  H       V   K   +W     S+   T    E   K   + Q  K + E++  
Sbjct: 1466 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1512

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            +K+++ E L      L K      ++   +LE  +K       T  E  N++   F E +
Sbjct: 1513 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1562

Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
            +  +E Q +    +++    +  Q        IC  L   +     LI   +  M   G 
Sbjct: 1563 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1619

Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
             E +  Q                   +++ L K +    Q L  V + T    +   + +
Sbjct: 1620 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1661

Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
             +E   L+   +++    C+  Q +LK  Q++        +EL K VT     E EK   
Sbjct: 1662 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1711

Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
            + +L+E ++  +++L       K S R     K ++ +   HF+E        + D+   
Sbjct: 1712 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1771

Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
             L + D+         N + +     A+++ I+ Q        ++  + L++ GQ + P 
Sbjct: 1772 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1831

Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
              E     L + +  L   +   +A ++ K    + +QE +        E+   ++ + Q
Sbjct: 1832 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1887

Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
             L  LEA    ++ + T L       E+ +S +   R I      + EA    +++  G 
Sbjct: 1888 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947

Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
              T    +    K+ H    +  L  +     + L+D    YQ +E     L   L++ +
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007

Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
               SK   E +  + K     L+   +L G +    +    LK+    L D    L P A
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2066

Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
                +  +    G  + L+ ++ E   + +  + +S+  Q  +   LDW+  V++ L   
Sbjct: 2067 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2126

Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
              + LN   +Q+ I K  + ++++      +NA++ K K+         ++ L+  + +L
Sbjct: 2127 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2186

Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
            S    +     +   A + E+ ++ + +  + +    +LE   Q L ++   G DV    
Sbjct: 2187 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2244

Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              L  +M+  ++E   H  +LE LHSL+  +     P+ K  + +K  +L  + + M   
Sbjct: 2245 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2302

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
               + + +  C  Q   +Q   + +   + +T KK+      F       S E  +KL E
Sbjct: 2303 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2362

Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
              +L                  +S V +  + I A++   + L  E T  +  +   ++ 
Sbjct: 2363 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2422

Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
            +T++ +  T +    +D   +L+D + E     +K++KA E    M+  LQ         
Sbjct: 2423 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2482

Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
             + P  +  +A K    T +E + +F  EL+Q  + +  L+ +   +L++   P   E P
Sbjct: 2483 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2536

Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
               Q +T +  +   + +      + +++   +    +T    +K W+ E +     LG 
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2596

Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
             +I+   ++ Q +++QILL E    +   E++    +    G+ +    + SL      Q
Sbjct: 2597 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2652

Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
            LA V      +  Q+ D+   ++Q+   S     Q Q L + L+  L+ L  K  + +  
Sbjct: 2653 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2708

Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
             T    + ++L+       E+    ++             L +   L   L++++  + +
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2768

Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
              +   ++AEN +  L  A +   ++ +M      W++  K         N +  +  + 
Sbjct: 2769 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2822

Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
             + ++L+++ K+    L A +   +   +    E  +  +   G E   L+  +     N
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2878

Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
                 K +K+ E +LK+   +LE+A           L  KEQ+   + L   ++  +  +
Sbjct: 2879 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2921

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
            + ++ C       E+ +A L        LQ+E    QH  + +       +++    +  
Sbjct: 2922 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2972

Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
            E    E K L Q ++    ++  K     N+       QE+  +  R  + A++     +
Sbjct: 2973 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3032

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
             + S     K LTM       L  +     LA+              GT D+  ++    
Sbjct: 3033 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3092

Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
              H ++      +C  L + +      + T  E+ S  A       S +PV     ++ +
Sbjct: 3093 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3152

Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
                  A+ + L A     D A        + E   P L       L  L +    L + 
Sbjct: 3153 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3211

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
               ++  +   ++R +++   L+  S     I L+ +E  E  + P   E++    Q  M
Sbjct: 3212 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3266

Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
             ++   ++EI  LQ        L + L+  + ++   +   L+  L  +  R  T+  K 
Sbjct: 3267 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3323

Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
            + +   L+E L   L   R + AL+        L SW++ T+  +     P  E   ++A
Sbjct: 3324 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3373

Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
            Q         L+D +   VE+                KV  L +LS+ +     L  KA 
Sbjct: 3374 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3433

Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
            T++         R+L+G  +  Q+  H+  + LN   T  EK   + +   TQ+  ++E 
Sbjct: 3434 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3483

Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
            +AQ +          +   K L Q ++  +SL + ++SR ++ ++Q           E  
Sbjct: 3484 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3538

Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
              +  + ++L Q L     K   ED++  M W   +H        Q++ST+    Q + L
Sbjct: 3539 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3596

Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
               QE +L  + N    LL+G+ L K      +   +   L+ +   +++++  S    +
Sbjct: 3597 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655

Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
               Q++ L ++L+       TWLD VE  L  +    L  EE        + L K+ K  
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3715

Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
               +D + N  S A  E        G  + V ED       R  L+   + Q+  ++   
Sbjct: 3716 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3769

Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
            + +                          +  F+Q    ++  I + E  L       +E
Sbjct: 3770 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3803

Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
              +   +LQV++    E+ + +D+ D+L+       +  ++    ++K + ++ L++   
Sbjct: 3804 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3863

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
            + +   E+            E  Q L+++  E ++ L     LTET  + IIS       
Sbjct: 3864 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3904

Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
                +L A A             LEY  ET       QQE  RQL           L+ E
Sbjct: 3905 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3932

Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
            ++  +             +N+  P+L + L  G+   I       ++  +Q+ E      
Sbjct: 3933 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3974

Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
              + K    L+  +   T++  +   ++  L+   +RL    +Q  ++  E+E +++ ++
Sbjct: 3975 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4029

Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
                 S +++    L  ++   G +++       K +    ++ +L ++   W ++ T +
Sbjct: 4030 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4089

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               + KL  L + +L  +      MS I  +++      D     I    + +  +  + 
Sbjct: 4090 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4146

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
             + +I+  Q  +D V    + + S+ + +    DK    + +  +N +W  L     ++I
Sbjct: 4147 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4202

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
              LE  +++  +Y++ +Q +  W +    +L     IG D  +V+  +++ +  +     
Sbjct: 4203 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262

Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
            ++ E+E++      L++   E+     V   L EL   W +L+  +   +  L+  L   
Sbjct: 4263 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4322

Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
               + A D++ ++L      LS  + + G  +A+++++     LQ+D+   + +++    
Sbjct: 4323 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4382

Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
              N L++         L N L+ +N RW N+LE+  ++ Q     L+   + K +  +  
Sbjct: 4383 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4439

Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
               Q   D    LL +       + A +++   ++ C        T K     L + G+Q
Sbjct: 4440 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4495

Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  +   SA + I  D  +L +   ++E  L +++T L+  +     F  SL+    W+ 
Sbjct: 4496 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4555

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
            +AE+ L       S  L T+  +++E K    + +S    +  L++ G  L      +++
Sbjct: 4556 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4614

Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
              ++NL       W  +  +  ER   L     + + F E     ME+L ++E+ L   +
Sbjct: 4615 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4674

Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
            EI+ +   +  Q   H+ FQ  + ++  +  +    G+ L E+  + DD  + +  L+ L
Sbjct: 4675 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4734

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
             ++W  +  ++ +R+  ++  +    ++ +  + L  WL  V    ++    V   +   
Sbjct: 4735 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4793

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
              L D      K F ++ G    +V+A K+    L+       + ++ ++ E+  +W++ 
Sbjct: 4794 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4849

Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
                  ++ +L   L+  E+    +   LE L   ++ L     LPD  + L     + K
Sbjct: 4850 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4909

Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
            E    +     +L + + + DT+ A    D I+ +   + +++ ++EE+       +Q++
Sbjct: 4910 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4969

Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
               L       E  + L  WL   E+ ++     +I + IE++K      + + EE+   
Sbjct: 4970 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5029

Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
            Q +  ++ +  +R A       SH                         ++IE K  +VN
Sbjct: 5030 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5089

Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
                +WQ +  L   R +KL + L  +++L
Sbjct: 5090 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5119



 Score =  298 bits (763), Expect = 2e-79
 Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)

Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
            E+EK  K  E +  DL           S A  S     ++  L      + ++YS    Y
Sbjct: 1137 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1196

Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
                +  N  L++   A+ L++L    L  E A        ENL S ++ + +E      
Sbjct: 1197 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1256

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
             FH+  +EL    A  D + K   + DL+     +K   L  R Q +      ++  L+ 
Sbjct: 1257 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1316

Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
              +    + D     ++ I+ +  T++K+ E    +  +S     +L++ K LVS +   
Sbjct: 1317 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1373

Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
              K+   ++ A Q   T  D    T++ R+M    Q+   + R +    + I+++ +D  
Sbjct: 1374 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1433

Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
            T +   V   T+ I    D L     E+ S  E     + H     EL++  S +     
Sbjct: 1434 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1486

Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
            +TL   +    P   ++    +EI+  +++     + +     K   K+  +E  + E  
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546

Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
            V+T   S      E+ + L       D ++EE            + + +  +E KEK  G
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1594

Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
            +  +L          + +  + +  ++LK     Q+++++  Q  A         T   L
Sbjct: 1595 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1654

Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
                +KL+++   +    L + K K + + ++A+  +K L + +     +  E  AAV++
Sbjct: 1655 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1714

Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
              E   ++   L     + K +E     H+Q I Q      +     S + E +E+   +
Sbjct: 1715 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1773

Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
            L+     +V   GT   N   Q ++    H+ ++ + + +       + + EK     S 
Sbjct: 1774 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1830

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
               EK+ + + EL    E      + +++      ++++KF+A+  + +  L+Q++  L 
Sbjct: 1831 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1890

Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
            + E G          LK Q S  + ++S    L+       + ++  +S  +     V +
Sbjct: 1891 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1950

Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
                    R  + A+    +   +CN++    +  V +Y+ YE     L           
Sbjct: 1951 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1999

Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
                   + +Q  +A  S+H  E +A   K  Q Q+    +      ++ + ++  + V 
Sbjct: 2000 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2047

Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
            +++  AE   D  G LLP  +     +    GR   L   V E             S ++
Sbjct: 2048 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2107

Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
            G         N E S     + P         ++++I   Q ++  +   +A  ++    
Sbjct: 2108 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2165

Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
               E  +P    S  AK+ DL   +    +   E    + E   + + +++  + + T +
Sbjct: 2166 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2225

Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
            E     L+E   PG+         Q    E L  +  + E+  SL +E+ S    +D A 
Sbjct: 2226 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2284

Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
             L   + L+   + M  TI+ K              Q+L + L   ++E  ++  + +  
Sbjct: 2285 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2344

Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
              A++L   L  TK   +       E   +    +   N++  +     A++  +V +  
Sbjct: 2345 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2402

Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
             +L G+    +  E  A K L  +K  + ++     D  L ++    E     S +    
Sbjct: 2403 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2462

Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
             +S  + +WL +   T T+ +Q+            ++Q K  E EL +  + ++ +  + 
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2522

Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
             E+L      E + D  E P         D   QEL         + E+SS         
Sbjct: 2523 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2576

Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
            E+  +++  +++L+ +VL            +++Q Q+L          Y +      G+ 
Sbjct: 2577 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2636

Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
               G+ P+  +  V   L  + Q ++ ++ Q         Q+I    +    + + S  L
Sbjct: 2637 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2695

Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
             D++ +L  + A+    T     NQ++      +   + +K +   +QA  E+     V 
Sbjct: 2696 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2751

Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
            E+ L   L R    +L S   V Q+     + LQ      +  + +        ++  +K
Sbjct: 2752 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2809

Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
                   P++ +++ ++      K+F   +       +K   E  ++             
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2869

Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
             +L+ ++  +D     +  R + L ++L    +Y+  ++ L   ++  Q  +   +  + 
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929

Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
             ++ E  I +L    KE  Q      +L  T    +    + KE  T  +  L+ +   V
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2989

Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
             ++ H +   LE + + +    E  +E  RQL+  +  +    S+G    +   L    T
Sbjct: 2990 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3045

Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
            + Q  + SL   + ++       + L++  S     SD+  Q+  + +   + + ++ ++
Sbjct: 3046 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105

Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
               LET L+    +Q+   ++        D L+        V ++ E ++        F 
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3161

Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
            K+++A  +   +   T   +L  ++   D   ++ +L  +  Q   LL    A +E++  
Sbjct: 3162 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3221

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
              + +L   +  S++  +  L++   + +E      +  + I++ L  +K F+ +    +
Sbjct: 3222 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3278

Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
              KQ  V+++ Q ++Q +++   ++  +       L  +N  W+ L   V ++   L+  
Sbjct: 3279 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3333

Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
            L     +++ ++ L +W  +T+E    Q+    +   V+  +++ + L+ L+  ++  VE
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3393

Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
             I++ G  +    +      ++  L  L   W  L +        L+ +           
Sbjct: 3394 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3453

Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
            + +N +L      L     +      ++ Q+   + L+DD+    + L +  SI  Q LK
Sbjct: 3454 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3512

Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
                   + +  +  + +  W     EI E+  S   LLQ                  + 
Sbjct: 3513 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3569

Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
            +      S +  Q+  T  L K  +   +  +++    Q+ +  LL GL  +K    D +
Sbjct: 3570 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3629

Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
              + +  E +K +      +    A  ++   L L++ L +  + LC     ++  +L Y
Sbjct: 3630 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3688

Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
            ET                ++L+G++ S +      Q R +ELK +     ++   LD LN
Sbjct: 3689 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3723

Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
            E+   L    P   +E   K +   N  + L+S   T++  ++ + +L+ Q F +  +  
Sbjct: 3724 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3783

Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
            + ++ +TE+KL    +I         Q +  + F  E+   + I+  ++  G +++    
Sbjct: 3784 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3843

Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
             +++     KL  +   +  + +   +R   ++       ++ E  E+L  WL E   + 
Sbjct: 3844 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3902

Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
               +  +P P  +  TL  + +   ++   + +   +I  +      LL    G      
Sbjct: 3903 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3953

Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
             E   IQEK+ +A     +++E  KK A  L +         D ++++    +++ + L 
Sbjct: 3954 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012

Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
                 + AE  + KE  +   + + D+ +L  L +TL        A     D  I    +
Sbjct: 4013 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4071

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
             ++++ +   WE +   +  R  ++ + +     F   +  L   +   +  +    D  
Sbjct: 4072 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4131

Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
            I+  + K +++     +EEI   QE    +  +G  L  A  E     ++  + ++N  W
Sbjct: 4132 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4191

Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
              L      R+ KL+E + A  Q    + ++  W+     +LA   PI  D    E +++
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4248

Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
            ++ E ++ + +  +    +  + +  E+LL        +++  ++Q     L   W ++ 
Sbjct: 4249 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4305

Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
               + R+ K+E       +F         WL  +E   +     G      + EL K   
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4365

Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
             Q  V    + +E +NK    L   +  + A +L+  +   NQRW N+ ++     ++L 
Sbjct: 4366 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425

Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
              + Q + F    + +  WLT+ +  L   +        AK +QL    +  +    K E
Sbjct: 4426 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4484

Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
                ++ +G+Q++ +        I+++++ L+   + V                   E  
Sbjct: 4485 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4525

Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
            L++R+ +LE++  L+ + +H+   D +    Q    L+++    L            +D+
Sbjct: 4526 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4573

Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
            +  + D     + ++ S   + +   D+ G   K F  +  V L  +      S  E  +
Sbjct: 4574 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4632

Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
            ++L   G++LDD+R + +Q         E +  S+     EL+ +            +K 
Sbjct: 4633 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4692

Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
            + K LG   S  D+  R    LKE+       + L   +   + + D+W+ +  +++ ++
Sbjct: 4693 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4749

Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
             ++++ L    QF   L ++  WL   E +L + Q +    DI  +   I   K  QK +
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4807

Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
              R + + ++   + E  +    +S  ++ ++ +++ RW+ VC+L    +  L+ AL Q 
Sbjct: 4808 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4867

Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
            + FH + H LL  L   ++  R + ++P D +     L D HK+ M+   +L E +  + 
Sbjct: 4868 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4923

Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
                M   +L           K  + +I  R + +L    +H + L   L    ++Q+L
Sbjct: 4924 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4982



 Score =  290 bits (741), Expect = 6e-77
 Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)

Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
            S L S+ S LE  K   +  E      E+ +KEA  SEI +    K    ++   ++ Q 
Sbjct: 658  SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 713

Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
             KL +T     + ++ +     +F S      +W+ EKE+E  A + S    +  I++ K
Sbjct: 714  AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 767

Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
                  ++E++ K  +I  ++E A+   Q +     AR  I+A    ++     + +  Q
Sbjct: 768  DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 824

Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
            C+E     H+ +   + E     +++     + K A+  K  C  ++  +K+   +QE M
Sbjct: 825  CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 880

Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
            +  + L    S I      A+ ++     N D  ++ +  ++     +Q E  + +  E 
Sbjct: 881  EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 940

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
              A  +  A W+ +    +  +           + E    A+R+  E + Q +  L +E 
Sbjct: 941  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 998

Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
                  VVS     +++ +++ S  +VAS   +K M     +  L  L  R+ D  +   
Sbjct: 999  HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1050

Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
               +  +S V       +L    +V  K +  EL  ++E    +  V    +  + +EV 
Sbjct: 1051 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1102

Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
            + +  L++ +  L + + +    +DLH    +  +  +L +E  ++ +      +   EF
Sbjct: 1103 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1162

Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
                A+ S +      L  + Q +    SM+    D + K +N  L+N +A E A V L 
Sbjct: 1163 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1219

Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
                   Y  K+   E           +  +   I+NL+ T +   SE D    +  A +
Sbjct: 1220 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1262

Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
            D+ ++  K+I D   +T KER       KE   Q +++   V  Q+++ L         L
Sbjct: 1263 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1314

Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
            +   K +      + P +D  I ++E T    +R I ENQ +    +      Q +    
Sbjct: 1315 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1369

Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
             +   SK+ E          T+KD E     +     ++ K   K++ +    S    ++
Sbjct: 1370 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1426

Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
             E   + +   +LV T M   +    D  ++LEE    L        + +    E++ W 
Sbjct: 1427 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1482

Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
            +N              P   + IS+ +   + E+L +  ++     A   +++  +  N+
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1542

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
            L++  K L+   +L F E+  +++L+ ++   +V K   K    +  + ++ +  I    
Sbjct: 1543 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1599

Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
            T+ E  L+   +     +    LKK +  Q+ELQ      +     +      +     E
Sbjct: 1600 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1659

Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
             L +    LI  K +EA     QL  K + S +E L+K  + +++E  E     K   + 
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1718

Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
                           + S+R G    +V+E      Q                N+L++  
Sbjct: 1719 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1778

Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
            DGQ                       S+  AV   TQ  Q L      +LS +    +Q+
Sbjct: 1779 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1838

Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
             + +    ++  L +  K  +       EL  F+  + +   W+ + E+    ENL    
Sbjct: 1839 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1896

Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
              I     ++ + + F         S D +S +G L  ++  G+   +  + CS+     
Sbjct: 1897 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947

Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
             +     +E  R    A     +L      +   +K + D+    E      L      E
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007

Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
               S+     +      ++  +   K  Q   SS +     ++   E L +    ++ + 
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2067

Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
               Q TL+ ++ ++ D  +  N+     E +   +   L  Q GL E    + +++S L 
Sbjct: 2068 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2124

Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
            E      ++ AL  +I+K+  L                    + +T D S   + Q ++K
Sbjct: 2125 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2184

Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
                +F++     KE + K+EE+     ++ +   +   +L +  + L        D + 
Sbjct: 2185 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2244

Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
             +Q       E ++ ++     L  + SL  E+  +   S   L+  +   L   +K+ E
Sbjct: 2245 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2300

Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
            D++ + +    SC E L                   ++ + +  F  +   L ++LE   
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2358

Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             L + W+ +                L+    T  + +     G  +L+  +     TE+ 
Sbjct: 2359 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2417

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
             +    L    +D++  S     L      L L+      N +    Q+ ++      QW
Sbjct: 2418 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2471

Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
            L  +N   T  +    P +   V T +++ + F +E +   +K+  +  K  ELL     
Sbjct: 2472 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2531

Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
              +A   +  +T     W+  +     ++  LE     +  F+     ++ WL + E MV
Sbjct: 2532 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2591

Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
                    D      ++Q++Q +L+E    +PQ  +L    Q +        S R     
Sbjct: 2592 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2651

Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
            +++ ++ ++ +L+    ++   +D+ + +  Q+   ++ L D ++D  + L S    ++ 
Sbjct: 2652 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2711

Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
               ++ +    + +    Q+++ Q+K+     E +      E +   + +QL+ +   + 
Sbjct: 2712 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771

Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
             +          L+ A +    +Q   R F  W+D+ +   N+S    A+L    +++  
Sbjct: 2772 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2831

Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
             K  ++ + + S + E    +G  +      +E    QL+L  ++  +    ++ KE   
Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2891

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
            K ++ +    +Y+  ++    W+ + Q  L++       A   E ++  L+ LQ    + 
Sbjct: 2892 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2950

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
              ++  + +T   ++   + + +   +    +SL Q       +L   +    N+  K +
Sbjct: 2951 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3008

Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
              ++  ++    L+ A+E++    S  ++  SN+    +Q  Q     + + A + +V+ 
Sbjct: 3009 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3063

Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
                AQ+++ E   S   S +  Q   +   +  L  QV E+  FLE ++Q +   ++++
Sbjct: 3064 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3123

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
                  +        ++A      +T+   K+ +T++  LK +E     L ++ +   + 
Sbjct: 3124 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3177

Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
             K +   E        +++++    +Q  +L    +     +E  +   +EF  K K  +
Sbjct: 3178 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3237

Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
              + + +E         ME      QL+ +K  Q+  +   +   + V   G+ L++   
Sbjct: 3238 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3297

Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
              T    L+  +D + + ++ L     +    L+  +     +   L+ +  W++     
Sbjct: 3298 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3356

Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
            LVA     ++  + +  Q+   K +   +   +  +  ++ +G+ +    A   +   K 
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3412

Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
             +   L      + A+ + A+   + LE          +TL+    WL+ ++  L     
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472

Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
                 ++  +Q+   +AL++                       +R   D++ S  D S  
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3532

Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
                  +      + ++Q L  A+   +   E+ +  +E+   L      D   + + ++
Sbjct: 3533 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3592

Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
             SEL        V Q    ++K    QA +N + E + + T  E      ++  +  ++ 
Sbjct: 3593 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3644

Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
            D+ + S ++    E+ LQ  R  H      C  + +V +E  + E   L   +A    + 
Sbjct: 3645 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3704

Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
             + LKK A   +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +
Sbjct: 3705 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761

Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
            K++ +    L      Q+   EL  W  E +  +          D     L        E
Sbjct: 3762 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3820

Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
            +   + ++  L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S
Sbjct: 3821 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3880

Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
               QF     +    + + +  I       L  + + +Q +  +  +  +  ++  +  +
Sbjct: 3881 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3940

Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
               G +L+ E++  E   +  K     ++Y  + +    R   L++ +     F +  D+
Sbjct: 3941 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3999

Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
                L++         ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++   
Sbjct: 4000 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4059

Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
               D       + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ 
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4118

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
            + +  F+R  + P  +        Q+    I +E+ GL E +D  +N   E   + G+P 
Sbjct: 4119 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4176

Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
            +P     +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + +
Sbjct: 4177 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4236

Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
            +      ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +
Sbjct: 4237 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4290

Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
            Q    ELKL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    + 
Sbjct: 4291 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350

Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
             + + I+ E+ K  + Q +V +    + A++    +    +    +++L++ L  L++  
Sbjct: 4351 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4410

Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
             ++ E    R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L
Sbjct: 4411 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4469

Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              HME    F + E+ + S +++   ++A        + + +++Q + +L+ + + +   
Sbjct: 4470 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4525

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
               +   L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EH
Sbjct: 4526 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4581

Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
            K   + VNS  E+I+ L++  + L+          +   + +V  RW ++     ++ + 
Sbjct: 4582 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4641

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            L+DA      F+    K  E +++ +  L           ++ T L  H  F   L  + 
Sbjct: 4642 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4701

Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
            S      +   S+          E+  L  +   + D    +++K  T  GK V+++ K 
Sbjct: 4702 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4752

Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
             E +         + ++  W+     Y   P +  D  +  ++ +++    NH+      
Sbjct: 4753 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4801

Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
                 +K LG  T      S+Q    AL    R+ I+    +    K   QELS + + +
Sbjct: 4802 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4849

Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
                 +  T+L+A                EE       L+E  A  ++ L  +G L    
Sbjct: 4850 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4897

Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
               +  L + H++ +++ E + ++LN+A +  +      + + +  I  WI   +     
Sbjct: 4898 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4957

Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
             +AW    Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E
Sbjct: 4958 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 5008

Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
             EE++ +I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 5009 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5065



 Score =  235 bits (599), Expect = 2e-60
 Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)

Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 620  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 675

Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 676  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 721

Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 722  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 776

Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 777  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 827

Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 828  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 886

Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 887  LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 946

Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 947  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1005

Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 1006 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1059

Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 1060 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1112

Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 1113 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1171

Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 1172 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1226

Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 1227 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1282

Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 1283 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1342

Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 1343 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1400

Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 1401 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1446

Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 1447 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1487

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 1488 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1541

Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601

Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1661

Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 1662 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1716

Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 1717 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1776

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 1777 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1833

Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 1834 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1893

Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 1894 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1953

Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 1954 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2013

Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
              +      +  D    +  L + + LQ   +  Q  +  +  T E   D   S +P   
Sbjct: 2014 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2068

Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
            D  + L+ +   ++     ++E   +    + +   ++    ++ +W+   E  +  + +
Sbjct: 2069 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128

Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
               N    +  + +     +++   +  +  +  + ++ ++ +  ++    QA    L++
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188

Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
            R+        + L +++ L+ +++  E     L ++ +               + ++   
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248

Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
            M     + LE   K +E  HSLLK     G  + K L   +   L K       + KE+ 
Sbjct: 2249 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2300

Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
             T++++   +         F    K+L  WI E  + + +  +P     +    L   K 
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2359

Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
            LQ+      P ++ V   G +L  L+  VT                              
Sbjct: 2360 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2419

Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
                  +K  +  +   Y+DL  + K+ +  L  K+   +    E   + +WL +M+   
Sbjct: 2420 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2479

Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
                  P   +T +++T  +Q                                      K
Sbjct: 2480 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2539

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
             M+ EI      LN L +     + + +++L      +A+LKQ      +   + G    
Sbjct: 2540 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2599

Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
               + +T ++  Q L   LQ+  +R+   +Q  A   A Q  L    + P  R    +Q+
Sbjct: 2600 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2653

Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
                A+ ++  +    L   CD +  A VK+T    Q   +++  KL    N       +
Sbjct: 2654 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2708

Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
                  +   L+ A +  Q +++   +++  +AQ +   +   VK+ +  +A ++  +E 
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2765

Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
            + K  K  E      + HL                   WLD  ++  N            
Sbjct: 2766 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2825

Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
               ++  +D  +T      M                      +++ L    T WD   + 
Sbjct: 2826 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2885

Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
              E      E+L+K                            L   E + +I  LK  ++
Sbjct: 2886 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2945

Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
            +M +H  + +             E+ KE  +   +   Q  D++  ++      LE +  
Sbjct: 2946 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 3004

Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
               +F+E  E ++E +  +  A +Q    D   +Q     +L +    +     LK  + 
Sbjct: 3005 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3062

Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
             A R+  DL      V++ + S   S V    + + Q    L++ + EK  FL    Q  
Sbjct: 3063 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3116

Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
               Q   R++   F E    L     V +  +T +  + ++K +  ++  L A      K
Sbjct: 3117 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3176

Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
                   TE+   +++G    L+ L    + +L +   R +++E  +   + F     + 
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3236

Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
               L++A+     +  +  E+  ++ QL  ++  + Q  E E L    Q     GQ ++ 
Sbjct: 3237 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3294

Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
            S         L   L+ +  ++  +      +  ++QEA+L    +   +E     + + 
Sbjct: 3295 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3354

Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
            E           +  V +A +  Q   + +LD+       V+ + ++ E   +T +P   
Sbjct: 3355 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3411

Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
             K+L  ++L    +  L  + E R   LE  +   Q+  +  + L   L ++  E+  VN
Sbjct: 3412 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3469

Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
             E +  +  KL+   +   +L+D  I   +       +   L  L+  + +  +QS    
Sbjct: 3470 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3529

Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
               W  E++  + +  E + +  C +++     F  +    ++WL  V  +LS     D 
Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3584

Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
            + + + ++  ++++ QE++   LR  N     L+  E  K T   E++   ++  L  + 
Sbjct: 3585 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3640

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
                DI +       TL +     +R +   +    WL+  + ELL      L  E A +
Sbjct: 3641 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3700

Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
                  E         + L+ L+ + + L  L+    +E LE+ VA    R + +S    
Sbjct: 3701 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3760

Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
             +V+ +     +   + +A +  +  + +TEKKL     ++     +   +L   K    
Sbjct: 3761 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3819

Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
             +    + I  L +   ++    ++  K ++ + +  V + +  +  +  ++   LE A 
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3879

Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
                 F    ++    + + Q  +    A       L    E H      + + +  +  
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3939

Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
            + +    +L+     +PGE   + ++  A       ++E VK     + + +        
Sbjct: 3940 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3995

Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
            +I+ +   ++   E L  P   I A++E+++  ++E  N   ++EK+       +++ E+
Sbjct: 3996 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4054

Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
             +        ++S +  +  LD  + I + I   ++E E       EL+   +K   D  
Sbjct: 4055 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4111

Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
            +++  +K   D              V Q +   + + EE+DG   +L  +     + +  
Sbjct: 4112 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4171

Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
             G+  KP+ KK I +L        +  ++R+ KL +A     +Y + L+ +  W++    
Sbjct: 4172 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4227

Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
            +A G +A  S S +       +  +EE K+  S  EA  ++++        E+++ Q   
Sbjct: 4228 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4276

Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
            L ++  E     +     +QD   ++K      E  +   Q  LE A   L   +     
Sbjct: 4277 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4331

Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
            L   L+H + LLSE + +   PK   ++L +  + +  DV+A      A  +        
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4390

Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
               EEAS LQ+         Q  + + EQ +Q++    +  +G H EIED          
Sbjct: 4391 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450

Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
                 KP+     +  + Q++ H E+    +  +E   SL  K + +  +   +      
Sbjct: 4451 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4509

Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
             ++  L E  E ++ +L    +     + +     ++L   +   +  E T +  S    
Sbjct: 4510 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4565

Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
               PS + +T    +++   +   +++ R Q    ++  + +  + F +          L
Sbjct: 4566 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4621

Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
              +Q  WE +   + E+ R+L +A +R +++ ++   +   +E  E  L    E    P+
Sbjct: 4622 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4681

Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
               +Q+A+H+    + L  +  + +  +     L  ++  AD  + L L   L+ L ++ 
Sbjct: 4682 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4738

Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
             TI  K+  ++  LEE L   L   +   ALQ        L  WL   +  L     P  
Sbjct: 4739 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4787

Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
              +D+   L+D      +   K  +  +    +   L+EG   ++D++  +  +++ L  
Sbjct: 4788 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4844

Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
                +      KQ  ++   ++ EE    + A     + EWLA+A  T            
Sbjct: 4845 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4899

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
              ++ + Q KE  ++L E+++ L    + G+ +L
Sbjct: 4900 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4933



 Score =  224 bits (570), Expect = 4e-57
 Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)

Query: 500  LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
            L+K +  EL  +L  L    E  S +  W+ K  +  +  Q        +   + +E +K
Sbjct: 2443 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2502

Query: 552  FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
             FE    Q     Q LK      ++ +    EA    + + E  ++W+ L+      +  
Sbjct: 2503 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2562

Query: 608  LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
            LEE  +N  ++    A L+ WL + E              MLN      +   +      
Sbjct: 2563 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2622

Query: 655  QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
             Q+  +  AG  ++     D  +   +K+QL  +  +W  L  ++       D+      
Sbjct: 2623 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2682

Query: 712  EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
            +Y   + +LS   ++   KLS  L VS     MN +L     + Q+++  ++++ V  A 
Sbjct: 2683 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2742

Query: 762  --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
                  + K  +L  + S Q EG  K       K +  +  ++  C S   ++  S+   
Sbjct: 2743 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2802

Query: 815  IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
              L+  +++    +    K++ + +++ + +  S  L  Q H  ++ +A  EN    L L
Sbjct: 2803 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2858

Query: 872  IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
              +GS+     + L+ +  ++D     +Q+ +     +  ++K   +K+ VET    + K
Sbjct: 2859 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2916

Query: 932  FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
             + +  E++  L  A EG       + L +   + F  ++      N+ L  C+   +++
Sbjct: 2917 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2975

Query: 990  PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
             ++ +  +Q+      +LH +   L+          ++  E  R L   +E   +LD   
Sbjct: 2976 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3032

Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
             L  Q  S K +    +  + +      + ++ L + L   L V     D+ GT  V L+
Sbjct: 3033 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3087

Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
             E  A   ST  + +++   + +   +    F + I    +Q      E    A  G   
Sbjct: 3088 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3147

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
              ++       K+ ET+     +L+ L  ++S + A K    +     +   LV +  ++
Sbjct: 3148 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3198

Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
            E   K  +   D  Q +E      +K  LEE  S  KE            + Q    ++T
Sbjct: 3199 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3257

Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
            E + +   +  +  +++ + +  K++DV    Q + Q+           H +L  + +  
Sbjct: 3258 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3316

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
              L +   ++  ++Q  L    RF+   E+++ ++  T    ++++  S +  + + +++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3375

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
            ++ K   +  +      E + +E  +I     P +K  + +Q   +  + + L +  E  
Sbjct: 3376 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3435

Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
             + +E +      F    E L+ W+T  EK L     + T +S ++ QI+Q K    +I 
Sbjct: 3436 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3495

Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
            +    +       QS     +  +   +++KL   + +  E++E +      +   L   
Sbjct: 3496 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3555

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
            + F E+  ++   ++E  DKL+  + +   +TE         +VLQE  D+    +++  
Sbjct: 3556 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3612

Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
            A+       ++    +  +   +  A++ +Y+DI + + +    LE  L   +RL     
Sbjct: 3613 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3672

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
               TWL++ E +  S E  +       + +++  + L+ E  +  +    L ++  +L  
Sbjct: 3673 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3731

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
            +      + ++  + + +ER+R +   I +++  + + +   QQFD+   +   WI    
Sbjct: 3732 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3791

Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
             +L +  +I +   Q +  L   K    E+   K  +  L     K+ +    E+   ++
Sbjct: 3792 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3851

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
             K +   + ++   Q+   R L L    S + +F +++  L   L +  Q++ +      
Sbjct: 3852 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3910

Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
             E + + +   +  Q  + +      +D +       L++   E          AD L  
Sbjct: 3911 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3970

Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
            +++           EA + +     F D+ +++L+S+E I ER  +        + ++++
Sbjct: 3971 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4027

Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
            +     +  ++   +     LK + +++        KD++ A  V  +++++   W++  
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4086

Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
             L+ E + +   +++L  ++           ++ S ++  + T   I+D ED       +
Sbjct: 4087 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4137

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
            K      ET + +++  Q++LD   + G  L++      K I       + +  +S    
Sbjct: 4138 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4197

Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
            W D  +KLEE M   + ++   D + +  D ++  +   +  M+   ++L+   +  E L
Sbjct: 4198 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4253

Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
            K+F+SE   + + +E L+   +  + L K +    D   ++  LM+ KL  +  +E    
Sbjct: 4254 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310

Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
             +  L+       Q +  ++++  W T  E  L          +  E  L K   +Q ++
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370

Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
             + QS + +  +  N L       E  +L   +  L ++ + V +   + +  L  +L  
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430

Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
             K F   +++ Q+W    +     S    G  +  + +L+    +  +    +    ++ 
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4490

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            Q+GQ + A   K   ++I + I    E++++   +  + K  L++  +    F +  +  
Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4550

Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
              W+ + E+  N  +           + + HKV  F  E+ + RE + +L + G  L  +
Sbjct: 4551 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4606

Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
                 Q+  L   LL S Q+    +++   E+ RS   A +  +   EA   +  W++  
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4666

Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
            +  L          D ++ +L+Q ++     G      +     G     ++S  +    
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726

Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
            +   L  L++ W  I   SV  Q+ LE  +     + +    L  W+  V+ ++      
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786

Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
               +     L+D+ ++   E    T ++  L   +REL E   +D S+     +EL T++
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4846

Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
              +  ++  K  ++E  ++    +   VH   +WL  A++ L     +  D  A +  + 
Sbjct: 4847 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4906

Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
            + KE +   E   + L++  ++   V           +   +  +RA   ++E+ +   +
Sbjct: 4907 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4963

Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
               + L S +A       G +A+ ++ LE   A L+ WA+  T L  K  D+E++     
Sbjct: 4964 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5006

Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
             QEI           E++K+ + E   F  +++     V  + K Y
Sbjct: 5007 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5040



 Score =  210 bits (535), Expect = 4e-53
 Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)

Query: 20  RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
           R+ DE++ VQK+TFTKWIN HL K +    V+DL+ED++DG  L++LLEVLSG  LP E+
Sbjct: 57  RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 114

Query: 80  GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
           GR   R H + N+  AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++ 
Sbjct: 115 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 172

Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
                              V+ E+               +AK+ LL W Q       GI 
Sbjct: 173 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 201

Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
            ++F   WR G  F+++IH  RP+L+D+ TV  +SN  NLE AF +AE ++G+ RLLDPE
Sbjct: 202 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 260

Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
           DVDV  PDEKS++TYV+     +P +     +G   +++   +  + N V    +  R  
Sbjct: 261 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 319

Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
              M       ER      +    L ++Y  FK   +      + K K++  L++     
Sbjct: 320 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 373

Query: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
           G++ L Q       ++      +W            G +   +   E ALR E+   ++ 
Sbjct: 374 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 415

Query: 436 EETANTIQR 444
           ++ AN +QR
Sbjct: 416 QQIANRVQR 424



 Score =  162 bits (411), Expect = 1e-38
 Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)

Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 1038 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1095

Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 1096 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1155

Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 1156 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1200

Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1251

Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 1252 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1311

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 1312 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1371

Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 1372 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1431

Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 1432 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1491

Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 1492 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1551

Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 1552 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1611

Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 1612 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1665

Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 1666 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1725

Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
              W+   ++  +     H                                      + T 
Sbjct: 1726 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1785

Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1845

Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 1846 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1905

Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 1906 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1965

Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2024

Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 2025 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2081

Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 2082 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2141

Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 2142 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2201

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 2202 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2256

Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 2257 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2315

Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 2316 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2373

Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 2374 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2433

Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 2434 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2493

Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553

Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2613

Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 2614 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2673

Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 2674 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2729

Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
                    V     E     DLS  ++    +A  S   EG  +  KD   +    +   
Sbjct: 2730 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2784

Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
             SA  S  Q +Q+ +   A  D++ + Q   + I +K      L   +K + K L   S 
Sbjct: 2785 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2844

Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
              + ++   E+ L + + S    + L     +T      W+    Q   +E ++K++L+K
Sbjct: 2845 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2899

Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
              ++   + ++W W+   +  LE+   ++   D    E  I KLK LQK +D    ++  
Sbjct: 2900 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2956

Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
            +N  +         +   + D    +  + D V   L   +  L++   + + F E+S  
Sbjct: 2957 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3016

Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
                L    E +D   +      SN    +LQ   K L  +KH++    L     QD+  
Sbjct: 3017 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3073

Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
            +   +++GT   +   +V  I      L ++V      LE KL  +   Q  +    S  
Sbjct: 3074 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3130

Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
                DELD+   V    GR     QK
Sbjct: 3131 AEFDDELDSMAPV----GRDAETLQK 3152



 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)

Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
            DL++W   +Q   DR E W     +V   LE  ++   A  EF      +SSLK + +S 
Sbjct: 639  DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 691

Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
                  LK     T   +L R++SQ+  LL N    QE+ H   +    SR A +E++ W
Sbjct: 692  IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 743

Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
            ++      +K+E+ +  +  +   +  + + K +  ++  +    +   +SV +I+ Q +
Sbjct: 744  LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 795

Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
                  +        AM   W  ILQ     +  + E    ++ E+ N+ +    +    
Sbjct: 796  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 853

Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
            +  +++++     +S+         LEDL++   +E E++ Q  + +A +  K + +  +
Sbjct: 854  KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 906

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
                     +T   +  +    +I +    D       +SH+  +  I+    EA     
Sbjct: 907  KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 966

Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
             F +   + EAV +      Q  N+  L  +     +S+  +  + N++ +     V   
Sbjct: 967  CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1026

Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
             T         L  +  R+ + LE+  E Q+ S   + QL        Q Y++  K    
Sbjct: 1027 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1086

Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
              Q++                    EDR    ++    +D   + V   I +   L K L
Sbjct: 1087 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1145

Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
              +KD L  +    E+   Q  A+A+S++ + +  L+  L  + Q      T +   +  
Sbjct: 1146 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1202

Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
                 K+ +A EA +      +  EE +     +  + +ST+++   E+  +   F ++ 
Sbjct: 1203 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1262

Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
             +L +   +   +    KE         ++   L   W  +  Q   R   L+     L 
Sbjct: 1263 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1322

Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
             ++      + W++ +  T++K+      N + L  Q    ++  +E+  +Q    S + 
Sbjct: 1323 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1378

Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
            + Q+  EQ     +D     +T                R ++DSQ +   + R M     
Sbjct: 1379 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1423

Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
              + E   L       V +  Q  +   D ++  E+                        
Sbjct: 1424 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1459

Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
               E +L+ E  E  EK K     L++    ++  LKD EK  K        S E++ T 
Sbjct: 1460 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1513

Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
            K++LS++L      L  H ++M  +E             Q+  L+++ +   S       
Sbjct: 1514 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1561

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
                 L Q Q  +    + +  + + ER  E   + EK + +C+ LTQ E+++  +    
Sbjct: 1562 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1613

Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
              GD  +E        E+L+KD Q        + +  +  L++ GE+L+   KA  E K 
Sbjct: 1614 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1673

Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
            +E + K  ++N + +     L  ++   +K+  E + AV+QL+++   + +L  WL++++
Sbjct: 1674 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1733

Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
              SE A    K ++             S   EE                   Q  LN+Q 
Sbjct: 1734 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1793

Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
            +      ++ I +H   + +  +  +VLL       +  E + +Q+  + L   +    A
Sbjct: 1794 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1852

Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
             S E+++K+  + +   +KF  DY+ FE WL+ SE+      +          +LK+ ++
Sbjct: 1853 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1911

Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
            F   V      L  I     R+             + D++ +   +++ +     R+ +L
Sbjct: 1912 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1971

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
              +   +   LK  + + + +E A   +L  L     + T  +H SE       ++Q ++
Sbjct: 1972 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2029

Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
            ++ KA Q +IS     +E++    E L++    L  A   I++ LD++    +++   V 
Sbjct: 2030 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2089

Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
              ++KL ++ L         R L ++D      L W      SL      P  S+ L   
Sbjct: 2090 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2139

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
            +++ +  E+      +S+++          ++  ++  M    PS     Q   KD   R
Sbjct: 2140 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2189

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             +   S  H    +++ +L   ++      ++ +  + +KT    E+D   K   +L   
Sbjct: 2190 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2248

Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
               S      LEHK   E   SL   ++ H   +  A V+++   L  +    E  +K+ 
Sbjct: 2249 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2306

Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
                    ++   F   + S+ +W+ +T ++                LE  ++L+    +
Sbjct: 2307 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2366

Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
            +T E+Q        L  L  AV      I ++     + + E T  +++E         +
Sbjct: 2367 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2426

Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
            +  ++ ++  ++ +  LL++    L   L + Q   E S  ++  L+ +++   +     
Sbjct: 2427 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2486

Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
            +  D E ++   +Q    + EL ++  +V  L+D   +LL   E  D  EA         
Sbjct: 2487 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2536

Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
            R K +L E+    +EL +L       L+ SS+        +  L  W    EL  S  + 
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2595

Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
            P S    PN   T R +  +     +   P            LS PG   S RG +   L
Sbjct: 2596 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2653

Query: 8746 RA 8747
             A
Sbjct: 2654 AA 2655



 Score = 54.7 bits (130), Expect = 4e-06
 Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)

Query: 366  EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
            E ++Q L   G+ SLD A  + + +    S+L +W  + +KSL + L          E+A
Sbjct: 4629 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4677

Query: 425  LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
                           + I+ +L QHK+  ++  A     H +Y T +  G  +       
Sbjct: 4678 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4721

Query: 479  ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
                   D L ++ +++  +   S        E  L   +F +    L+  L   E +L 
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781

Query: 525  SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
                 +G  + V  L+ N+ +F    K   +   + Q LK++A   +  +GS +++  V 
Sbjct: 4782 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4836

Query: 585  KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
              M E + +W  +     S ++ LE  +   + + + V +L  WL +AE+      +L  
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896

Query: 639  SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
             E+A        K+F + L     +       G+ ++  C       +K  + ++  R+ 
Sbjct: 4897 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956

Query: 692  ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
            E+    KQ+ Q  A  +  +  K+E  + ++    +A T    K  E +      VK LI
Sbjct: 4957 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5016

Query: 747  QD----LEDIEQRVPVMDAQYKIITKT 769
             +    +E++ ++ P +D     +TKT
Sbjct: 5017 AEHQTFMEEMTRKQPDVDK----VTKT 5039



 Score = 33.9 bits (76), Expect = 7.3
 Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
            Q +QL+++      A + +E+  LR  C  V+ +      +  +L +      L+    +
Sbjct: 487  QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 541

Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
                +  S L        SL     SS+++  L+  + S  +   TPA     P      
Sbjct: 542  TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 590

Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
              L  +  S +      E    Q  K   +R  +  S   D +  E +I     + L   
Sbjct: 591  -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 643

Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
            +D+ + Q+ +TE    S  P+      ++K   + + E  SS+      E K+ E + + 
Sbjct: 644  VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 696

Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
            P        +   A  + R E   A+ L+     +++L     F S   +   WL + EE
Sbjct: 697  P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749

Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
            E       E++ D       I + K    EL + +D ++  I S+   + +    +    
Sbjct: 750  E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 802

Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
              ++   + M  +W  +  L +     +++     + F++       L  L++  +RK  
Sbjct: 803  LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 860

Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
                D +     L+D  ++ M+ K ELL+ +  +A+L   +  ++ +    +DC
Sbjct: 861  -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 913



 Score = 33.5 bits (75), Expect = 9.6
 Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)

Query: 375  DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
            D  L LD  L  ++  WD +  +  +   +L+++L         L  +  WLYR E  L 
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781

Query: 427  EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
            E+  V    +   N I       K+L + T    A KR+  E+      +   V   Q++
Sbjct: 4782 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4840

Query: 484  DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
            +++ R+  V + S     ++        EF  + + LL  L  AE  L+   +     ++
Sbjct: 4841 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900

Query: 536  VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
            +  L+  +  F                +K+  E   + + +    + V+   +     T 
Sbjct: 4901 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944

Query: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
              W      +  +R+  EEV++   ++   +AS  A L            AK++    L 
Sbjct: 4945 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4987

Query: 652  HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
             W+Q       A   L +   E++ +++++   L+     + FME     Q D +D++ K
Sbjct: 4988 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5038

Query: 712  EY 713
             Y
Sbjct: 5039 TY 5040


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  372 bits (955), Expect = e-102
 Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)

Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 1325 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1381

Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440

Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
                T    +V    +Y+   G S +R       +SL  E ++  E +K  +        
Sbjct: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1498

Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
             +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D   +
Sbjct: 1499 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552

Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
              E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L  +
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
             ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K   
Sbjct: 1613 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1669

Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
                 EDK  +  K+  +     K  Q ++   Q+ + L   +T                
Sbjct: 1670 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1711

Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
                A++++ E +  +++ +E +T +ENLL     ++K+           +    T  + 
Sbjct: 1712 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1767

Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
            G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+  
Sbjct: 1768 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1827

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
            +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD  
Sbjct: 1828 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1885

Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
               F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+   
Sbjct: 1886 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1945

Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
                        K+ +     ++      A D F+       V+      L  L +  Q 
Sbjct: 1946 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 2002

Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
            +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ + 
Sbjct: 2003 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2061

Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
              A+  L    S    +   + T D + G  E +   +  +  +         + QD  +
Sbjct: 2062 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2121

Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  + 
Sbjct: 2122 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2181

Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
             D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  + 
Sbjct: 2182 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2241

Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
             + T   +  KD  +L               Y Q+    F    KHL    S LK+I S 
Sbjct: 2242 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2287

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
                + +D    ++K  ++S+K +E  D ++      + V S +++++ +        + 
Sbjct: 2288 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2341

Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
            + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   + 
Sbjct: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2400

Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
            TP                AK I  V  G  + +    +T  E+F  +     T +++ + 
Sbjct: 2401 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2442

Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
            + +       L  +KD   EL ++ S +   QE  +++ +        +     T     
Sbjct: 2443 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2501

Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
             EAV     KTQ    +S E    +++ + QE                     L+ KL +
Sbjct: 2502 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2535

Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
            L                + +   T  A   KQ+       +T+ + ++Q   +  +  +Q
Sbjct: 2536 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2572

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
             L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E  
Sbjct: 2573 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2630

Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
              +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A+ 
Sbjct: 2631 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2690

Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
            +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K+ 
Sbjct: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
             A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +  
Sbjct: 2751 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809

Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
               + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        + 
Sbjct: 2810 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2860

Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
            IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + V 
Sbjct: 2861 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2919

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
                W+                    Q  L +IK  +D  E G + +++++SL  E+ Q+
Sbjct: 2920 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2961

Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
                  EL++    +L +  +  ++ V      L   V  +          +  + Q  +
Sbjct: 2962 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019

Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
            +F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R +
Sbjct: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079

Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
            +DL   +    G          + +E++ L  Q  + C   E  LQ         +    
Sbjct: 3080 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3139

Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
             F +F   L +          + +    +   L+K++  ++ ++N      MML+  E  
Sbjct: 3140 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3199

Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
              L+      GI+  + A  +           +E  +E    ++++F    +     L K
Sbjct: 3200 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3253

Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
             E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    +A
Sbjct: 3254 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3307

Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
            +KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D   
Sbjct: 3308 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3367

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
            ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I +
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3427

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
            QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E    +
Sbjct: 3428 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3487

Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
                   + + K L +++++++  L      G  +       +  + Q +L   Q  Y  
Sbjct: 3488 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3547

Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
            IQE++       ++ +   + +  D      WL +  +KL + SV +         ++ L
Sbjct: 3548 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3607

Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
            R LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++  
Sbjct: 3608 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3665

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
                  +   R +    +++  WL   E E +S  T+        + Q+   ++KK  + 
Sbjct: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3725

Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
              A  D + EV +   E++      +R G +    +   RY+ +   + ++++ ++  I 
Sbjct: 3726 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782

Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
              ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     +   
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3837

Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
            ++    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +F 
Sbjct: 3838 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3897

Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
            +  + L  W+ E Q I+     P +E    + Q  +++ L++ +  H+P +  + + G  
Sbjct: 3898 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957

Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
            LLEL   +  ++++K     + Y  +    K+   +L+  +     ++ ++ ++ + L +
Sbjct: 3958 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4017

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
            +  RL  P  + ++ +E I +Q++ +K +  ++   +     L+ +G+ +I +       
Sbjct: 4018 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4076

Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
              A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T++
Sbjct: 4077 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4129

Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
              Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +  
Sbjct: 4130 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4187

Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
               VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L +M
Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247

Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
                ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   + L
Sbjct: 4248 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4305

Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
             +    W  L  +  N   + E  L     +   ++ +  +L               +  
Sbjct: 4306 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4365

Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
            A+ +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  + 
Sbjct: 4366 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4425

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            +  +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H+ 
Sbjct: 4426 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4485

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
            +C+  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  L 
Sbjct: 4486 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4545

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
            +AL+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++ +
Sbjct: 4546 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4605

Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
            +  L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F E
Sbjct: 4606 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665

Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
             + K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+++
Sbjct: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725

Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     L 
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
             +E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R   
Sbjct: 4786 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4843

Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
              W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+  
Sbjct: 4844 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4900

Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
                LP +E      +  +      L++    L + T   + +     P +    +H I 
Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4960

Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
              +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + + 
Sbjct: 4961 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 5015

Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
            I +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD     
Sbjct: 5016 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5074

Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
              R   ++L    SQ Q             ++ QV+  A       ND L+  +EL + A
Sbjct: 5075 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5134

Query: 5020 GNGLDV 5025
                D+
Sbjct: 5135 NFDFDI 5140



 Score =  340 bits (873), Expect = 3e-92
 Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)

Query: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 1152 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1209

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
            K++ + L   +L     AE+ +K +  K    E+V   +  ++N +S +        E  
Sbjct: 1210 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1266

Query: 551  KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
            + F   E        ++ ++ K   E  +  D   E+A+ +++       +W+N+ V++ 
Sbjct: 1267 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1319

Query: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
            +    LE +  +   Y +T   L  W++  E        NQ EN+K    + N    +  
Sbjct: 1320 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1379

Query: 657  HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
               M  +     +   E  S  +K   L       +++ + +     VK+       D +
Sbjct: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1436

Query: 710  KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
             +E+ D     +A  T     +++ ++ +  ++K L ++ + +E+       + K + K 
Sbjct: 1437 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1492

Query: 770  AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
               I+K  +  ++ GK  F+      E+++  KE  S  L   Q  L             
Sbjct: 1493 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552

Query: 819  ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
            ELEKQ+ +  +S   +        +E+Q+S   K + + +   Q+  K+ L         
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612

Query: 871  ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
                        +I  G+  ++K+ +    L+  D     + +A++    ++ +K+ G+ 
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1671

Query: 919  -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
                 K  +E           +L  K E+S+ EL+KV+  A +E  E+    ++L    T
Sbjct: 1672 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1731

Query: 965  EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
            +  + LD      +L   D+ ++    + +Q +++     H Q  D       + E   +
Sbjct: 1732 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1783

Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
            LL   +D +    + + +E   +  ++ K       EKII +H+ V  + +    L EK+
Sbjct: 1784 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1835

Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
             Q +  EE   K  ++  +++        L E    +  T+  L E+ +K+  DYT    
Sbjct: 1836 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1887

Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
            EF  W+  +E +L+ ++  A D      ++KR      + ++ +G+      S  +VL  
Sbjct: 1888 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1947

Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
              S         + +    +   KL  +     +L S+   + +N  D V   +  +++ 
Sbjct: 1948 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2007

Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
              L++G +  +  A K L +E +    + L    ++TK +  +    Q  + + ++    
Sbjct: 2008 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066

Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
            L D     L     ++ TLD        L +S   +  ++Q+TL +    +   + ++ +
Sbjct: 2067 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2126

Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
            +    SS +      L+ ++L+  +S  +   ++ + R  SI    E  VK+  E    P
Sbjct: 2127 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2184

Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
                 LQ + K +  +  +     +E +  ME +KTK + F +  E L  ++  K + L 
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244

Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
             ++     +      ++ +  E       +  L    +  +      + A +  K   + 
Sbjct: 2245 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2304

Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
            +  +E+ +  +  +  +     Q   F+  ++ ++  + E                    
Sbjct: 2305 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2364

Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
             ED   +  K      E  KV    + LC  + ++++   A +A  S   V+N +     
Sbjct: 2365 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2424

Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
                       S  ++   +   YED+    K++   L   L+  Q+ ++E S+ + WL+
Sbjct: 2425 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2484

Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
            +    A+  +      D  A + +VE        L+  V        KL +L E      
Sbjct: 2485 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2544

Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
                 K M   L ++D +W++L Q+   R   L+       QF  +      W+   +L 
Sbjct: 2545 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2601

Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
            +S L   S           ++ I+  + A TR   +         + S+ GE  SL+G +
Sbjct: 2602 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2659

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
             K       +    L G+  D     ++A     + Q  L  L+                
Sbjct: 2660 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2719

Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
                    + L++   +   ++Q ++ ++   ++ ++ S L++++   A + ++ LE   
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2778

Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
             S   +  KA+ H+     +   S  A++ Q        Q  L TK+ E +        L
Sbjct: 2779 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2833

Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
             VL+   +D K+  + L +   + E+T  E      + +   + ALQ +L       D  
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2893

Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
            N      E++L    +KA +  ++     P +D+  N LE      D  +        + 
Sbjct: 2894 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2953

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
            + +   Q  G+++L+    N   +V +     V +   S+I     + +Q        E+
Sbjct: 2954 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3013

Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
            +   F + +     +K ++   ++ LD   S G    S                     +
Sbjct: 3014 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3073

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
            L K  + D  +  +D + T D  L V E + +    L   +      L T+ +  G   N
Sbjct: 3074 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3132

Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
             + +M    +  D+ L       R  E L++ +  +K    +LE L +  ++  +  K +
Sbjct: 3133 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3192

Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
                ET PDL  I+ DL    +   ++ + A+       A+  QVE  I  +  +++K++
Sbjct: 3193 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3245

Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
            E    L    ++E  +             L   K  QKE    LQ +Q +++   + L  
Sbjct: 3246 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3305

Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
               K  S   + L   +  +  + + +++  ++  A LQE+L     F ++++    W +
Sbjct: 3306 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3363

Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
              +         + + KV++A++ + + +   + D +S ++ + +EG+ +          
Sbjct: 3364 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423

Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
             I +Q++  +  ++A L +     + L+  +     F +    LN W+  +E+R  N E 
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483

Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
            +G     + E+       ++++      L + ++  +SL  LS R      E     Q  
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3537

Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
               SQ+   +  +   +  +    Q AL   +   E    +  W+  + D+L+       
Sbjct: 3538 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3595

Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
            S + L K+ S++    +DILL K      ++ A+  G + L+ +  +   +IQ +LE +K
Sbjct: 3596 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3651

Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
              + DI   S     TLE  +           +L  W++ V+ ++          E   Q
Sbjct: 3652 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3711

Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
             Q   KE      + +++L    + + AL  L+  ++RE  EK   E            +
Sbjct: 3712 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3762

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            +  +     +K+ +++  +     +  A      W+   +++L    D+  +   T  +L
Sbjct: 3763 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3822

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
               K    + EI   +         ++  +   SG ++M    +  +   K+  D V + 
Sbjct: 3823 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
               +  + S+  L  +     V Q  +  E+    L      ++ L     + E + +  
Sbjct: 3872 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3931

Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
             + +++ + + + +P  + +     +L   S       G+   + ++Y   + L  Q  +
Sbjct: 3932 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3985

Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
              + +   L +   ++   F   +     +  +  +  +    +S  ++KI+E +SE++N
Sbjct: 3986 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044

Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
                +  +    E L      ++ +         AK +Q K+      W+N H+ + ++E
Sbjct: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104

Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
            + L ++    + F      +   +  T+  + +  +   D    +++Q+  +++ EEI  
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4164

Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
             + +L+ +     +L    G+      +  + +L+S + +L+   K+++ +L+  +    
Sbjct: 4165 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4224

Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
            Q+  G++ + DW+  A   L S     +D   +  +  +L+   S   +++I+M+ +  +
Sbjct: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4284

Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
             E +L+  + E    T+Q  L  +K +W SL    I  + +LEGAL     +Q  + +  
Sbjct: 4285 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4344

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
             W+   E  L+E +    + +     L K  +L  +VL++ S +E +   G  + E    
Sbjct: 4345 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4404

Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
                  Q +L+ L +R++ + E+ ++   + +  +R  + +  +++  + WL   +  L 
Sbjct: 4405 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4464

Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
                L G   T +  L    E+       +    S++   + ++      AE   D+ + 
Sbjct: 4465 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4524

Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
            +L++ W++ + +L+E +T+    +N         Q    WL  AE+ ++  +R      T
Sbjct: 4525 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4584

Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
               Q+ + K +  EV ++R+++ E+      +   S     +  +     + SR++ ++ 
Sbjct: 4585 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4644

Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
            +++E+ + L++  +  ++   + S   +W   + K+  +   +A   DK+ T     +L 
Sbjct: 4645 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4699

Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
              +   K +   HS+  +    G R++K       + L+  + D + +L++   T+    
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4756

Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
             +    LE+ L  + +F+D  +AL  W+   +  L   +    ++      +  +K+ Q+
Sbjct: 4757 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4816

Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
             +     SV++++     L+E  +D +  +K ++ +L + ++ +C++       LEA ++
Sbjct: 4817 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4876

Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
              E+++S +  + +WL +    L    V PD  +  +L T+  Q   HK  M+++     
Sbjct: 4877 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4931

Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
             LN     GDT++  C       +K  +       +  +  + + A++  Q L   L   
Sbjct: 4932 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4987

Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
            +++Q+ L+   AWL   +  L    +  +      ++++  +AL  + +T+++
Sbjct: 4988 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 5035



 Score =  320 bits (819), Expect = 5e-86
 Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
            HQQ    + ++  D  +   ++Q   G    +  +E+   +     L +S ER+E+   V
Sbjct: 1045 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1104

Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
                   +R    R E  ++ ++R +    +    HE     +  E L  ELE+ K+   
Sbjct: 1105 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1161

Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
               +I  + E    +A+     P  +  L    +++  QV  +  T  + +KT+ +V   
Sbjct: 1162 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1220

Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
                 +  +     + E+E    A+    + ++  IS +K    E++ K      LE+E 
Sbjct: 1221 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1276

Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
            Q     S   F T  E                        +I  +L  +   G+ L+ + 
Sbjct: 1277 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1336

Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
                 L+  I       Q+ E   RKIQ++  E    LA  +          ++ Q  MD
Sbjct: 1337 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1389

Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
             CQ   E  S+ +  +            +  +  V R      A  + Q++ D+    + 
Sbjct: 1390 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1445

Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
            R TAL  L+  +        +RLE+E  S     +    KA   +  +S   +   + E 
Sbjct: 1446 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1505

Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
                    + +S     +K  QL E+L ++         +L L +  ++  D      + 
Sbjct: 1506 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1550

Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
             N L+  V   Q+   LL S S+     L E QT+ ++ + + ++   R +++  +++  
Sbjct: 1551 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1606

Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
               L   +  L     +G  E   +  G  E            +++ Q     L + +Q 
Sbjct: 1607 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1649

Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
             A +L+ +++     + E    +++ +  LIE+ LN+A    + L    E +   LD ++
Sbjct: 1650 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1709

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
            + A         ++ T   A   QL     +I+NLL                        
Sbjct: 1710 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1761

Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
            GT   E D     K A  ++ E    LL++  D +  T +E L +  ++   Q  ++ +Q
Sbjct: 1762 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1817

Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
             +  + + +     L+ + + ++ ++     ++ + +  L+V ++          +L H 
Sbjct: 1818 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1874

Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
             Q +         E+++      + LEN    A  +    T +K Q+        H+   
Sbjct: 1875 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1932

Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
                    DL   T  G  +L   K     D   V T          +V  KL+   DR 
Sbjct: 1933 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1979

Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
            R   S  +       D++      E  S   +  +    +    HL            R 
Sbjct: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039

Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
             E  K  + ++ ++ + +E+L      L +   +L     D+Q    D++ + E   +  
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2099

Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
                  L+    +S  V+  ++++  W   VE SL    Q   N T   + + K   +++
Sbjct: 2100 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2159

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            ++  +QS+I++  E +         +   SL   M  L  +    S    +T A ++E  
Sbjct: 2160 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2219

Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
             K    E++ E  + FL  K  A    D  G   V E   + +Q       + +  L+ +
Sbjct: 2220 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2277

Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
                + + +H      + + E+    +++F+       + K+A+  C  +L +F+   + 
Sbjct: 2278 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337

Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
            L  WI E  ++       F  E+LG+S +   +       K  E+ KV    + L  L++
Sbjct: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397

Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
            A     +++  +   G +L+ EG     E    ++ LTS           +++L  + K+
Sbjct: 2398 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2457

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
            K+      L + +  +E   +M  W++ +       + T    DT   +    Q+     
Sbjct: 2458 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2514

Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
             E E+K N+  + + +  L    +E     +       L  +   W ++   ++  Q  L
Sbjct: 2515 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2574

Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
            E   +    +   + QL+QW+   +  +    PL   P +         +Q +L E    
Sbjct: 2575 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2632

Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
                 +L A  + +  +  ED S +   +E+L   TQ  D +T    ++   +++ +   
Sbjct: 2633 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2692

Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
              Y   +   +D L     +L     +S    A  ++L    K+K+ I  + ++I  ++ 
Sbjct: 2693 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2751

Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
            +  E L+  VK+       E +  E+ + L    K ++D   + ++ +++L S  A S Q
Sbjct: 2752 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2804

Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
                     +Q    F A L T  ++          L +LE    D +        Q  +
Sbjct: 2805 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2856

Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
                 AE     LK+Q +E       L+T         K+            + +E  L+
Sbjct: 2857 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2905

Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
            +   KA +  +Q      W+   +    +   C D  +  + ++   SLQK + +     
Sbjct: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965

Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
            E   +  N +LS  E+   ++T E    IQ KV    E        LH K+  LEN+  +
Sbjct: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 3017

Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
             K+F EVS E  +      E++ +H+S   L       +    LQ+  + +   + Q++ 
Sbjct: 3018 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3074

Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
             K  AQ L    + SK       +V  ++ ++  LS    EK S L+  +     F   I
Sbjct: 3075 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134

Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
            +E+     +    LDS      D   L  +         KLEAL++         KM++ 
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3194

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
              E     TSP+ +  I++ L+++      LL      + Q+EG + +   +   +++FS
Sbjct: 3195 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3248

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
              +   E +         E       L   K+   EE+       + +   G G+     
Sbjct: 3249 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3308

Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
              T     + +L D+  R++ + ++  +   + ++ +     +Q  L++   W+   +E 
Sbjct: 3309 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368

Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
            +        +    +  +++ + LQ    + ++ +  +    E +  +  P  + + L+ 
Sbjct: 3369 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3428

Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
            L      W+A  ++      Q   +    +   +  + ++EWL T E+++       +  
Sbjct: 3429 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3488

Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
            +  E Q+ Q K   +++  +   + +  +  Q +       D+  V S++        + 
Sbjct: 3489 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3548

Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
             + +     LL Q L   K F E+E++ +           +W    H     ++  +   
Sbjct: 3549 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3595

Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
             T  + K+   L VL +D+      +  A   G   +K     E   ++ ++     + K
Sbjct: 3596 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3655

Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
            ++T        TLE+ L LA+      + L  W+ + +  L   E   ++  E      +
Sbjct: 3656 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3715

Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
             K L++   +++  + S+ E   ALLELV       L+  + +    Y+ +     + V 
Sbjct: 3716 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3775

Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
             ++A +   + ++        W+ +   +L++   +     +T + QL   K    EI  
Sbjct: 3776 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3834

Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
             +D +++L   G  ++  C++  +  +K+ +   L+    +Y  IC      Y  LE   
Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3890

Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
                   +T ++   WL+  Q  +   P P L       + +  R  QE+ R   +L+  
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3943

Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
                 +   KT  + ++ +     +I++K V A  L   + +IK    +  + L +A   
Sbjct: 3944 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 4000

Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
                    DQ L++++R    L        E+   +  +S+ K+    ++  Q    T+ 
Sbjct: 4001 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4060

Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
            ++  ++  +    +     K +    DQ + +    + L  +RE    D+    +   C 
Sbjct: 4061 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4120

Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
            ++  +   K T ++      D E   +    +K+   A +  +  I+ L+++        
Sbjct: 4121 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4176

Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
             ++I      DK +VK+    L   W  L    K +I      ++     Q   Q + +W
Sbjct: 4177 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4236

Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
             +     +A                E LKQ       Q + M+ L   +EL     LLK 
Sbjct: 4237 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4291

Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
            + +++D+            +Q  L + +   + L + +  R+  L  AL    QF  A+ 
Sbjct: 4292 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341

Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
            +  + +   E  +  ++ +   P  +  ++      Q  +  +Q+ V  +   G +L++ 
Sbjct: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401

Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
               +E S +  KL+ L   + +VL+K   R Q+L+  L   K F  + +    WL   + 
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461

Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
                   L         QL  +  +       E    +L + GQ +L    +   + + +
Sbjct: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521

Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
             +N L  ++  +     ++  K++EA+    E+ + ++     L++ E Q L ++  P+ 
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4579

Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
            L ++  L   D  +   +EV    E + EL++     +   Q        + ++ + + +
Sbjct: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639

Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
             ++ ++  +R   L+D    A Q HE   K+ + LE   KS+  E    N+    +T  A
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699

Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
            + K     L   HS+  +   +G  LK  T   +D           K    +   + +  
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4750

Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
             +     E   + E  ++ S  F   +   +DWL RV+ +L+   PV+ D++L  +   I
Sbjct: 4751 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4808

Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
               +  Q+E+      + AL    +E    +++  S+ ++  + ELS     +     ++
Sbjct: 4809 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4867

Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
            Q  L     Q + ++ V  A  +WL +A++ L+  G   D E A   L   H EF    +
Sbjct: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927

Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
            +  + L +  ++  T+  +  P             +   E+ +A  +   QR++      
Sbjct: 4928 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4987

Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
             A+ +LL+   A  QW +     K +E + + + + +  ++E   F    T    + ++ 
Sbjct: 4988 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047

Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
               +K   +  +S    I  L++         AS L  +G+     T +  +  +  +W 
Sbjct: 5048 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5107

Query: 5194 RLRAVAQDQEKILEDAVD 5211
            ++  +A ++ + L DA+D
Sbjct: 5108 QVWLLALERRRKLNDALD 5125



 Score =  318 bits (815), Expect = 1e-85
 Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)

Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
            V+    W+D M+  L+ +E   ++L    + L   K ++  +  + S L+  ++    MT
Sbjct: 648  VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706

Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
                  L+L   ++ +R   + AK   T   +   L  LH    R      +WL +++E+
Sbjct: 707  ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 761

Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
               Y   E + +       H   +R+L + + +    Q +   +L       P+ +    
Sbjct: 762  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 818

Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
             RA    +  W     Q  +  + E    F              ++  ++L+  ++ +  
Sbjct: 819  YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 870

Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
            +    R S+    E  + +  +  EE+  Y+  +  +  +A+ I+     NS    + + 
Sbjct: 871  KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 930

Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
              +    Y+ + + + +  + +        + ++ S   +E+ + S        +K   +
Sbjct: 931  PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 990

Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
            +A +I++       + + TL     + +K +   H L+      R     ++K +  GE 
Sbjct: 991  LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1045

Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
            ++    L+    D +E  +E       +   LEK +++ K++             YQE+L
Sbjct: 1046 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1092

Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
               E  + E       +S+ ++++  + + E   ++ +R      +  E++  + +   L
Sbjct: 1093 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1152

Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
            K ++++L+ D   + +  +E  FS  A         SEL  V + + Q   MS   +  D
Sbjct: 1153 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1209

Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
             L+T +L     Q A      +   + EE A   D+ NN++    TL  Q    +  K +
Sbjct: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1266

Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
            Q  HA L+       AI     + Y+  + +   H  + D L   + W +  VQ D    
Sbjct: 1267 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1321

Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
                L   E I K +K++R        ++             V+TT + IQ+ +    +T
Sbjct: 1322 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1366

Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
            +  +L Q + L     EI+  +S++    + A+Q    +K    EL+    + MV   + 
Sbjct: 1367 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1421

Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
               K +  Q+S + II++   L  +     +  +  L  Q++     S     + E+ L+
Sbjct: 1422 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1476

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
              +  H       V   K   +W     S+   T    E   K   + Q  K + E++  
Sbjct: 1477 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1523

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            +K+++ E L      L K      ++   +LE  +K       T  E  N++   F E +
Sbjct: 1524 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1573

Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
            +  +E Q +    +++    +  Q        IC  L   +     LI   +  M   G 
Sbjct: 1574 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1630

Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
             E +  Q                   +++ L K +    Q L  V + T    +   + +
Sbjct: 1631 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672

Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
             +E   L+   +++    C+  Q +LK  Q++        +EL K VT     E EK   
Sbjct: 1673 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1722

Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
            + +L+E ++  +++L       K S R     K ++ +   HF+E        + D+   
Sbjct: 1723 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1782

Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
             L + D+         N + +     A+++ I+ Q        ++  + L++ GQ + P 
Sbjct: 1783 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1842

Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
              E     L + +  L   +   +A ++ K    + +QE +        E+   ++ + Q
Sbjct: 1843 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1898

Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
             L  LEA    ++ + T L       E+ +S +   R I      + EA    +++  G 
Sbjct: 1899 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958

Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
              T    +    K+ H    +  L  +     + L+D    YQ +E     L   L++ +
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018

Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
               SK   E +  + K     L+   +L G +    +    LK+    L D    L P A
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2077

Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
                +  +    G  + L+ ++ E   + +  + +S+  Q  +   LDW+  V++ L   
Sbjct: 2078 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2137

Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
              + LN   +Q+ I K  + ++++      +NA++ K K+         ++ L+  + +L
Sbjct: 2138 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2197

Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
            S    +     +   A + E+ ++ + +  + +    +LE   Q L ++   G DV    
Sbjct: 2198 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2255

Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              L  +M+  ++E   H  +LE LHSL+  +     P+ K  + +K  +L  + + M   
Sbjct: 2256 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2313

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
               + + +  C  Q   +Q   + +   + +T KK+      F       S E  +KL E
Sbjct: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2373

Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
              +L                  +S V +  + I A++   + L  E T  +  +   ++ 
Sbjct: 2374 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2433

Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
            +T++ +  T +    +D   +L+D + E     +K++KA E    M+  LQ         
Sbjct: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493

Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
             + P  +  +A K    T +E + +F  EL+Q  + +  L+ +   +L++   P   E P
Sbjct: 2494 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2547

Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
               Q +T +  +   + +      + +++   +    +T    +K W+ E +     LG 
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607

Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
             +I+   ++ Q +++QILL E    +   E++    +    G+ +    + SL      Q
Sbjct: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2663

Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
            LA V      +  Q+ D+   ++Q+   S     Q Q L + L+  L+ L  K  + +  
Sbjct: 2664 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2719

Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
             T    + ++L+       E+    ++             L +   L   L++++  + +
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2779

Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
              +   ++AEN +  L  A +   ++ +M      W++  K         N +  +  + 
Sbjct: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2833

Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
             + ++L+++ K+    L A +   +   +    E  +  +   G E   L+  +     N
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2889

Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
                 K +K+ E +LK+   +LE+A           L  KEQ+   + L   ++  +  +
Sbjct: 2890 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2932

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
            + ++ C       E+ +A L        LQ+E    QH  + +       +++    +  
Sbjct: 2933 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2983

Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
            E    E K L Q ++    ++  K     N+       QE+  +  R  + A++     +
Sbjct: 2984 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3043

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
             + S     K LTM       L  +     LA+              GT D+  ++    
Sbjct: 3044 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3103

Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
              H ++      +C  L + +      + T  E+ S  A       S +PV     ++ +
Sbjct: 3104 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3163

Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
                  A+ + L A     D A        + E   P L       L  L +    L + 
Sbjct: 3164 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3222

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
               ++  +   ++R +++   L+  S     I L+ +E  E  + P   E++    Q  M
Sbjct: 3223 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3277

Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
             ++   ++EI  LQ        L + L+  + ++   +   L+  L  +  R  T+  K 
Sbjct: 3278 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3334

Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
            + +   L+E L   L   R + AL+        L SW++ T+  +     P  E   ++A
Sbjct: 3335 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3384

Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
            Q         L+D +   VE+                KV  L +LS+ +     L  KA 
Sbjct: 3385 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3444

Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
            T++         R+L+G  +  Q+  H+  + LN   T  EK   + +   TQ+  ++E 
Sbjct: 3445 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3494

Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
            +AQ +          +   K L Q ++  +SL + ++SR ++ ++Q           E  
Sbjct: 3495 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3549

Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
              +  + ++L Q L     K   ED++  M W   +H        Q++ST+    Q + L
Sbjct: 3550 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3607

Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
               QE +L  + N    LL+G+ L K      +   +   L+ +   +++++  S    +
Sbjct: 3608 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666

Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
               Q++ L ++L+       TWLD VE  L  +    L  EE        + L K+ K  
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726

Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
               +D + N  S A  E        G  + V ED       R  L+   + Q+  ++   
Sbjct: 3727 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3780

Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
            + +                          +  F+Q    ++  I + E  L       +E
Sbjct: 3781 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3814

Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
              +   +LQV++    E+ + +D+ D+L+       +  ++    ++K + ++ L++   
Sbjct: 3815 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3874

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
            + +   E+            E  Q L+++  E ++ L     LTET  + IIS       
Sbjct: 3875 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3915

Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
                +L A A             LEY  ET       QQE  RQL           L+ E
Sbjct: 3916 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3943

Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
            ++  +             +N+  P+L + L  G+   I       ++  +Q+ E      
Sbjct: 3944 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3985

Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
              + K    L+  +   T++  +   ++  L+   +RL    +Q  ++  E+E +++ ++
Sbjct: 3986 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4040

Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
                 S +++    L  ++   G +++       K +    ++ +L ++   W ++ T +
Sbjct: 4041 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4100

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               + KL  L + +L  +      MS I  +++      D     I    + +  +  + 
Sbjct: 4101 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
             + +I+  Q  +D V    + + S+ + +    DK    + +  +N +W  L     ++I
Sbjct: 4158 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
              LE  +++  +Y++ +Q +  W +    +L     IG D  +V+  +++ +  +     
Sbjct: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273

Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
            ++ E+E++      L++   E+     V   L EL   W +L+  +   +  L+  L   
Sbjct: 4274 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4333

Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
               + A D++ ++L      LS  + + G  +A+++++     LQ+D+   + +++    
Sbjct: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4393

Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
              N L++         L N L+ +N RW N+LE+  ++ Q     L+   + K +  +  
Sbjct: 4394 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4450

Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
               Q   D    LL +       + A +++   ++ C        T K     L + G+Q
Sbjct: 4451 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4506

Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  +   SA + I  D  +L +   ++E  L +++T L+  +     F  SL+    W+ 
Sbjct: 4507 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4566

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
            +AE+ L       S  L T+  +++E K    + +S    +  L++ G  L      +++
Sbjct: 4567 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4625

Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
              ++NL       W  +  +  ER   L     + + F E     ME+L ++E+ L   +
Sbjct: 4626 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4685

Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
            EI+ +   +  Q   H+ FQ  + ++  +  +    G+ L E+  + DD  + +  L+ L
Sbjct: 4686 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4745

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
             ++W  +  ++ +R+  ++  +    ++ +  + L  WL  V    ++    V   +   
Sbjct: 4746 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4804

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
              L D      K F ++ G    +V+A K+    L+       + ++ ++ E+  +W++ 
Sbjct: 4805 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860

Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
                  ++ +L   L+  E+    +   LE L   ++ L     LPD  + L     + K
Sbjct: 4861 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4920

Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
            E    +     +L + + + DT+ A    D I+ +   + +++ ++EE+       +Q++
Sbjct: 4921 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4980

Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
               L       E  + L  WL   E+ ++     +I + IE++K      + + EE+   
Sbjct: 4981 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5040

Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
            Q +  ++ +  +R A       SH                         ++IE K  +VN
Sbjct: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5100

Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
                +WQ +  L   R +KL + L  +++L
Sbjct: 5101 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5130



 Score =  298 bits (763), Expect = 2e-79
 Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)

Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
            E+EK  K  E +  DL           S A  S     ++  L      + ++YS    Y
Sbjct: 1148 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1207

Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
                +  N  L++   A+ L++L    L  E A        ENL S ++ + +E      
Sbjct: 1208 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1267

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
             FH+  +EL    A  D + K   + DL+     +K   L  R Q +      ++  L+ 
Sbjct: 1268 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1327

Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
              +    + D     ++ I+ +  T++K+ E    +  +S     +L++ K LVS +   
Sbjct: 1328 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1384

Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
              K+   ++ A Q   T  D    T++ R+M    Q+   + R +    + I+++ +D  
Sbjct: 1385 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1444

Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
            T +   V   T+ I    D L     E+ S  E     + H     EL++  S +     
Sbjct: 1445 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1497

Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
            +TL   +    P   ++    +EI+  +++     + +     K   K+  +E  + E  
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557

Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
            V+T   S      E+ + L       D ++EE            + + +  +E KEK  G
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1605

Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
            +  +L          + +  + +  ++LK     Q+++++  Q  A         T   L
Sbjct: 1606 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1665

Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
                +KL+++   +    L + K K + + ++A+  +K L + +     +  E  AAV++
Sbjct: 1666 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1725

Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
              E   ++   L     + K +E     H+Q I Q      +     S + E +E+   +
Sbjct: 1726 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1784

Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
            L+     +V   GT   N   Q ++    H+ ++ + + +       + + EK     S 
Sbjct: 1785 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1841

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
               EK+ + + EL    E      + +++      ++++KF+A+  + +  L+Q++  L 
Sbjct: 1842 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1901

Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
            + E G          LK Q S  + ++S    L+       + ++  +S  +     V +
Sbjct: 1902 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1961

Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
                    R  + A+    +   +CN++    +  V +Y+ YE     L           
Sbjct: 1962 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 2010

Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
                   + +Q  +A  S+H  E +A   K  Q Q+    +      ++ + ++  + V 
Sbjct: 2011 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2058

Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
            +++  AE   D  G LLP  +     +    GR   L   V E             S ++
Sbjct: 2059 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118

Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
            G         N E S     + P         ++++I   Q ++  +   +A  ++    
Sbjct: 2119 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2176

Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
               E  +P    S  AK+ DL   +    +   E    + E   + + +++  + + T +
Sbjct: 2177 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236

Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
            E     L+E   PG+         Q    E L  +  + E+  SL +E+ S    +D A 
Sbjct: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2295

Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
             L   + L+   + M  TI+ K              Q+L + L   ++E  ++  + +  
Sbjct: 2296 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2355

Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
              A++L   L  TK   +       E   +    +   N++  +     A++  +V +  
Sbjct: 2356 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2413

Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
             +L G+    +  E  A K L  +K  + ++     D  L ++    E     S +    
Sbjct: 2414 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2473

Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
             +S  + +WL +   T T+ +Q+            ++Q K  E EL +  + ++ +  + 
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2533

Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
             E+L      E + D  E P         D   QEL         + E+SS         
Sbjct: 2534 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2587

Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
            E+  +++  +++L+ +VL            +++Q Q+L          Y +      G+ 
Sbjct: 2588 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2647

Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
               G+ P+  +  V   L  + Q ++ ++ Q         Q+I    +    + + S  L
Sbjct: 2648 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2706

Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
             D++ +L  + A+    T     NQ++      +   + +K +   +QA  E+     V 
Sbjct: 2707 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2762

Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
            E+ L   L R    +L S   V Q+     + LQ      +  + +        ++  +K
Sbjct: 2763 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2820

Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
                   P++ +++ ++      K+F   +       +K   E  ++             
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880

Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
             +L+ ++  +D     +  R + L ++L    +Y+  ++ L   ++  Q  +   +  + 
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940

Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
             ++ E  I +L    KE  Q      +L  T    +    + KE  T  +  L+ +   V
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000

Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
             ++ H +   LE + + +    E  +E  RQL+  +  +    S+G    +   L    T
Sbjct: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3056

Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
            + Q  + SL   + ++       + L++  S     SD+  Q+  + +   + + ++ ++
Sbjct: 3057 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116

Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
               LET L+    +Q+   ++        D L+        V ++ E ++        F 
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3172

Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
            K+++A  +   +   T   +L  ++   D   ++ +L  +  Q   LL    A +E++  
Sbjct: 3173 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3232

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
              + +L   +  S++  +  L++   + +E      +  + I++ L  +K F+ +    +
Sbjct: 3233 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3289

Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
              KQ  V+++ Q ++Q +++   ++  +       L  +N  W+ L   V ++   L+  
Sbjct: 3290 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3344

Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
            L     +++ ++ L +W  +T+E    Q+    +   V+  +++ + L+ L+  ++  VE
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404

Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
             I++ G  +    +      ++  L  L   W  L +        L+ +           
Sbjct: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464

Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
            + +N +L      L     +      ++ Q+   + L+DD+    + L +  SI  Q LK
Sbjct: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3523

Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
                   + +  +  + +  W     EI E+  S   LLQ                  + 
Sbjct: 3524 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3580

Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
            +      S +  Q+  T  L K  +   +  +++    Q+ +  LL GL  +K    D +
Sbjct: 3581 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3640

Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
              + +  E +K +      +    A  ++   L L++ L +  + LC     ++  +L Y
Sbjct: 3641 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3699

Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
            ET                ++L+G++ S +      Q R +ELK +     ++   LD LN
Sbjct: 3700 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3734

Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
            E+   L    P   +E   K +   N  + L+S   T++  ++ + +L+ Q F +  +  
Sbjct: 3735 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3794

Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
            + ++ +TE+KL    +I         Q +  + F  E+   + I+  ++  G +++    
Sbjct: 3795 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3854

Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
             +++     KL  +   +  + +   +R   ++       ++ E  E+L  WL E   + 
Sbjct: 3855 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3913

Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
               +  +P P  +  TL  + +   ++   + +   +I  +      LL    G      
Sbjct: 3914 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3964

Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
             E   IQEK+ +A     +++E  KK A  L +         D ++++    +++ + L 
Sbjct: 3965 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023

Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
                 + AE  + KE  +   + + D+ +L  L +TL        A     D  I    +
Sbjct: 4024 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
             ++++ +   WE +   +  R  ++ + +     F   +  L   +   +  +    D  
Sbjct: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142

Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
            I+  + K +++     +EEI   QE    +  +G  L  A  E     ++  + ++N  W
Sbjct: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202

Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
              L      R+ KL+E + A  Q    + ++  W+     +LA   PI  D    E +++
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4259

Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
            ++ E ++ + +  +    +  + +  E+LL        +++  ++Q     L   W ++ 
Sbjct: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4316

Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
               + R+ K+E       +F         WL  +E   +     G      + EL K   
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4376

Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
             Q  V    + +E +NK    L   +  + A +L+  +   NQRW N+ ++     ++L 
Sbjct: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436

Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
              + Q + F    + +  WLT+ +  L   +        AK +QL    +  +    K E
Sbjct: 4437 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4495

Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
                ++ +G+Q++ +        I+++++ L+   + V                   E  
Sbjct: 4496 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4536

Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
            L++R+ +LE++  L+ + +H+   D +    Q    L+++    L            +D+
Sbjct: 4537 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4584

Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
            +  + D     + ++ S   + +   D+ G   K F  +  V L  +      S  E  +
Sbjct: 4585 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4643

Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
            ++L   G++LDD+R + +Q         E +  S+     EL+ +            +K 
Sbjct: 4644 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4703

Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
            + K LG   S  D+  R    LKE+       + L   +   + + D+W+ +  +++ ++
Sbjct: 4704 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4760

Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
             ++++ L    QF   L ++  WL   E +L + Q +    DI  +   I   K  QK +
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4818

Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
              R + + ++   + E  +    +S  ++ ++ +++ RW+ VC+L    +  L+ AL Q 
Sbjct: 4819 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4878

Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
            + FH + H LL  L   ++  R + ++P D +     L D HK+ M+   +L E +  + 
Sbjct: 4879 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4934

Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
                M   +L           K  + +I  R + +L    +H + L   L    ++Q+L
Sbjct: 4935 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4993



 Score =  290 bits (741), Expect = 6e-77
 Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)

Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
            S L S+ S LE  K   +  E      E+ +KEA  SEI +    K    ++   ++ Q 
Sbjct: 669  SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 724

Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
             KL +T     + ++ +     +F S      +W+ EKE+E  A + S    +  I++ K
Sbjct: 725  AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 778

Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
                  ++E++ K  +I  ++E A+   Q +     AR  I+A    ++     + +  Q
Sbjct: 779  DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 835

Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
            C+E     H+ +   + E     +++     + K A+  K  C  ++  +K+   +QE M
Sbjct: 836  CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 891

Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
            +  + L    S I      A+ ++     N D  ++ +  ++     +Q E  + +  E 
Sbjct: 892  EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 951

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
              A  +  A W+ +    +  +           + E    A+R+  E + Q +  L +E 
Sbjct: 952  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 1009

Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
                  VVS     +++ +++ S  +VAS   +K M     +  L  L  R+ D  +   
Sbjct: 1010 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1061

Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
               +  +S V       +L    +V  K +  EL  ++E    +  V    +  + +EV 
Sbjct: 1062 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1113

Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
            + +  L++ +  L + + +    +DLH    +  +  +L +E  ++ +      +   EF
Sbjct: 1114 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1173

Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
                A+ S +      L  + Q +    SM+    D + K +N  L+N +A E A V L 
Sbjct: 1174 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1230

Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
                   Y  K+   E           +  +   I+NL+ T +   SE D    +  A +
Sbjct: 1231 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1273

Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
            D+ ++  K+I D   +T KER       KE   Q +++   V  Q+++ L         L
Sbjct: 1274 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1325

Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
            +   K +      + P +D  I ++E T    +R I ENQ +    +      Q +    
Sbjct: 1326 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1380

Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
             +   SK+ E          T+KD E     +     ++ K   K++ +    S    ++
Sbjct: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1437

Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
             E   + +   +LV T M   +    D  ++LEE    L        + +    E++ W 
Sbjct: 1438 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1493

Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
            +N              P   + IS+ +   + E+L +  ++     A   +++  +  N+
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1553

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
            L++  K L+   +L F E+  +++L+ ++   +V K   K    +  + ++ +  I    
Sbjct: 1554 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1610

Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
            T+ E  L+   +     +    LKK +  Q+ELQ      +     +      +     E
Sbjct: 1611 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1670

Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
             L +    LI  K +EA     QL  K + S +E L+K  + +++E  E     K   + 
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1729

Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
                           + S+R G    +V+E      Q                N+L++  
Sbjct: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789

Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
            DGQ                       S+  AV   TQ  Q L      +LS +    +Q+
Sbjct: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1849

Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
             + +    ++  L +  K  +       EL  F+  + +   W+ + E+    ENL    
Sbjct: 1850 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1907

Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
              I     ++ + + F         S D +S +G L  ++  G+   +  + CS+     
Sbjct: 1908 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958

Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
             +     +E  R    A     +L      +   +K + D+    E      L      E
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018

Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
               S+     +      ++  +   K  Q   SS +     ++   E L +    ++ + 
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2078

Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
               Q TL+ ++ ++ D  +  N+     E +   +   L  Q GL E    + +++S L 
Sbjct: 2079 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2135

Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
            E      ++ AL  +I+K+  L                    + +T D S   + Q ++K
Sbjct: 2136 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2195

Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
                +F++     KE + K+EE+     ++ +   +   +L +  + L        D + 
Sbjct: 2196 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2255

Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
             +Q       E ++ ++     L  + SL  E+  +   S   L+  +   L   +K+ E
Sbjct: 2256 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2311

Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
            D++ + +    SC E L                   ++ + +  F  +   L ++LE   
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2369

Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             L + W+ +                L+    T  + +     G  +L+  +     TE+ 
Sbjct: 2370 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2428

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
             +    L    +D++  S     L      L L+      N +    Q+ ++      QW
Sbjct: 2429 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2482

Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
            L  +N   T  +    P +   V T +++ + F +E +   +K+  +  K  ELL     
Sbjct: 2483 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2542

Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
              +A   +  +T     W+  +     ++  LE     +  F+     ++ WL + E MV
Sbjct: 2543 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2602

Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
                    D      ++Q++Q +L+E    +PQ  +L    Q +        S R     
Sbjct: 2603 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2662

Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
            +++ ++ ++ +L+    ++   +D+ + +  Q+   ++ L D ++D  + L S    ++ 
Sbjct: 2663 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2722

Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
               ++ +    + +    Q+++ Q+K+     E +      E +   + +QL+ +   + 
Sbjct: 2723 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782

Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
             +          L+ A +    +Q   R F  W+D+ +   N+S    A+L    +++  
Sbjct: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2842

Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
             K  ++ + + S + E    +G  +      +E    QL+L  ++  +    ++ KE   
Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2902

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
            K ++ +    +Y+  ++    W+ + Q  L++       A   E ++  L+ LQ    + 
Sbjct: 2903 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2961

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
              ++  + +T   ++   + + +   +    +SL Q       +L   +    N+  K +
Sbjct: 2962 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019

Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
              ++  ++    L+ A+E++    S  ++  SN+    +Q  Q     + + A + +V+ 
Sbjct: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3074

Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
                AQ+++ E   S   S +  Q   +   +  L  QV E+  FLE ++Q +   ++++
Sbjct: 3075 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3134

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
                  +        ++A      +T+   K+ +T++  LK +E     L ++ +   + 
Sbjct: 3135 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3188

Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
             K +   E        +++++    +Q  +L    +     +E  +   +EF  K K  +
Sbjct: 3189 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3248

Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
              + + +E         ME      QL+ +K  Q+  +   +   + V   G+ L++   
Sbjct: 3249 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3308

Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
              T    L+  +D + + ++ L     +    L+  +     +   L+ +  W++     
Sbjct: 3309 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3367

Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
            LVA     ++  + +  Q+   K +   +   +  +  ++ +G+ +    A   +   K 
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3423

Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
             +   L      + A+ + A+   + LE          +TL+    WL+ ++  L     
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483

Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
                 ++  +Q+   +AL++                       +R   D++ S  D S  
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3543

Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
                  +      + ++Q L  A+   +   E+ +  +E+   L      D   + + ++
Sbjct: 3544 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3603

Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
             SEL        V Q    ++K    QA +N + E + + T  E      ++  +  ++ 
Sbjct: 3604 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3655

Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
            D+ + S ++    E+ LQ  R  H      C  + +V +E  + E   L   +A    + 
Sbjct: 3656 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3715

Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
             + LKK A   +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +
Sbjct: 3716 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772

Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
            K++ +    L      Q+   EL  W  E +  +          D     L        E
Sbjct: 3773 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831

Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
            +   + ++  L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S
Sbjct: 3832 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891

Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
               QF     +    + + +  I       L  + + +Q +  +  +  +  ++  +  +
Sbjct: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951

Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
               G +L+ E++  E   +  K     ++Y  + +    R   L++ +     F +  D+
Sbjct: 3952 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4010

Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
                L++         ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++   
Sbjct: 4011 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4070

Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
               D       + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ 
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4129

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
            + +  F+R  + P  +        Q+    I +E+ GL E +D  +N   E   + G+P 
Sbjct: 4130 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4187

Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
            +P     +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + +
Sbjct: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247

Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
            +      ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +
Sbjct: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4301

Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
            Q    ELKL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    + 
Sbjct: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361

Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
             + + I+ E+ K  + Q +V +    + A++    +    +    +++L++ L  L++  
Sbjct: 4362 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4421

Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
             ++ E    R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L
Sbjct: 4422 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4480

Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              HME    F + E+ + S +++   ++A        + + +++Q + +L+ + + +   
Sbjct: 4481 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4536

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
               +   L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EH
Sbjct: 4537 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4592

Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
            K   + VNS  E+I+ L++  + L+          +   + +V  RW ++     ++ + 
Sbjct: 4593 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4652

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            L+DA      F+    K  E +++ +  L           ++ T L  H  F   L  + 
Sbjct: 4653 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4712

Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
            S      +   S+          E+  L  +   + D    +++K  T  GK V+++ K 
Sbjct: 4713 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4763

Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
             E +         + ++  W+     Y   P +  D  +  ++ +++    NH+      
Sbjct: 4764 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4812

Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
                 +K LG  T      S+Q    AL    R+ I+    +    K   QELS + + +
Sbjct: 4813 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860

Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
                 +  T+L+A                EE       L+E  A  ++ L  +G L    
Sbjct: 4861 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4908

Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
               +  L + H++ +++ E + ++LN+A +  +      + + +  I  WI   +     
Sbjct: 4909 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4968

Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
             +AW    Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E
Sbjct: 4969 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 5019

Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
             EE++ +I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 5020 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5076



 Score =  235 bits (599), Expect = 2e-60
 Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)

Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 631  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 686

Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 687  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 732

Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 733  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 787

Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 788  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 838

Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 839  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897

Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 898  LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 957

Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 958  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1016

Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 1017 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1070

Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 1071 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1123

Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 1124 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1182

Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 1183 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1237

Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 1238 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1293

Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 1294 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353

Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1411

Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 1412 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1457

Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 1458 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 1499 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1552

Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612

Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672

Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 1673 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1727

Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 1728 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1787

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1844

Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 1845 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1904

Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 1905 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1964

Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024

Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
              +      +  D    +  L + + LQ   +  Q  +  +  T E   D   S +P   
Sbjct: 2025 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2079

Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
            D  + L+ +   ++     ++E   +    + +   ++    ++ +W+   E  +  + +
Sbjct: 2080 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139

Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
               N    +  + +     +++   +  +  +  + ++ ++ +  ++    QA    L++
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199

Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
            R+        + L +++ L+ +++  E     L ++ +               + ++   
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259

Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
            M     + LE   K +E  HSLLK     G  + K L   +   L K       + KE+ 
Sbjct: 2260 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2311

Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
             T++++   +         F    K+L  WI E  + + +  +P     +    L   K 
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2370

Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
            LQ+      P ++ V   G +L  L+  VT                              
Sbjct: 2371 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2430

Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
                  +K  +  +   Y+DL  + K+ +  L  K+   +    E   + +WL +M+   
Sbjct: 2431 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2490

Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
                  P   +T +++T  +Q                                      K
Sbjct: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2550

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
             M+ EI      LN L +     + + +++L      +A+LKQ      +   + G    
Sbjct: 2551 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2610

Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
               + +T ++  Q L   LQ+  +R+   +Q  A   A Q  L    + P  R    +Q+
Sbjct: 2611 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2664

Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
                A+ ++  +    L   CD +  A VK+T    Q   +++  KL    N       +
Sbjct: 2665 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2719

Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
                  +   L+ A +  Q +++   +++  +AQ +   +   VK+ +  +A ++  +E 
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2776

Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
            + K  K  E      + HL                   WLD  ++  N            
Sbjct: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2836

Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
               ++  +D  +T      M                      +++ L    T WD   + 
Sbjct: 2837 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2896

Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
              E      E+L+K                            L   E + +I  LK  ++
Sbjct: 2897 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2956

Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
            +M +H  + +             E+ KE  +   +   Q  D++  ++      LE +  
Sbjct: 2957 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 3015

Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
               +F+E  E ++E +  +  A +Q    D   +Q     +L +    +     LK  + 
Sbjct: 3016 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3073

Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
             A R+  DL      V++ + S   S V    + + Q    L++ + EK  FL    Q  
Sbjct: 3074 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127

Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
               Q   R++   F E    L     V +  +T +  + ++K +  ++  L A      K
Sbjct: 3128 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3187

Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
                   TE+   +++G    L+ L    + +L +   R +++E  +   + F     + 
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3247

Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
               L++A+     +  +  E+  ++ QL  ++  + Q  E E L    Q     GQ ++ 
Sbjct: 3248 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3305

Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
            S         L   L+ +  ++  +      +  ++QEA+L    +   +E     + + 
Sbjct: 3306 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3365

Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
            E           +  V +A +  Q   + +LD+       V+ + ++ E   +T +P   
Sbjct: 3366 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3422

Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
             K+L  ++L    +  L  + E R   LE  +   Q+  +  + L   L ++  E+  VN
Sbjct: 3423 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3480

Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
             E +  +  KL+   +   +L+D  I   +       +   L  L+  + +  +QS    
Sbjct: 3481 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540

Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
               W  E++  + +  E + +  C +++     F  +    ++WL  V  +LS     D 
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3595

Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
            + + + ++  ++++ QE++   LR  N     L+  E  K T   E++   ++  L  + 
Sbjct: 3596 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3651

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
                DI +       TL +     +R +   +    WL+  + ELL      L  E A +
Sbjct: 3652 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3711

Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
                  E         + L+ L+ + + L  L+    +E LE+ VA    R + +S    
Sbjct: 3712 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771

Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
             +V+ +     +   + +A +  +  + +TEKKL     ++     +   +L   K    
Sbjct: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3830

Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
             +    + I  L +   ++    ++  K ++ + +  V + +  +  +  ++   LE A 
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3890

Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
                 F    ++    + + Q  +    A       L    E H      + + +  +  
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3950

Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
            + +    +L+     +PGE   + ++  A       ++E VK     + + +        
Sbjct: 3951 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4006

Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
            +I+ +   ++   E L  P   I A++E+++  ++E  N   ++EK+       +++ E+
Sbjct: 4007 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4065

Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
             +        ++S +  +  LD  + I + I   ++E E       EL+   +K   D  
Sbjct: 4066 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4122

Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
            +++  +K   D              V Q +   + + EE+DG   +L  +     + +  
Sbjct: 4123 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4182

Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
             G+  KP+ KK I +L        +  ++R+ KL +A     +Y + L+ +  W++    
Sbjct: 4183 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4238

Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
            +A G +A  S S +       +  +EE K+  S  EA  ++++        E+++ Q   
Sbjct: 4239 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4287

Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
            L ++  E     +     +QD   ++K      E  +   Q  LE A   L   +     
Sbjct: 4288 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342

Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
            L   L+H + LLSE + +   PK   ++L +  + +  DV+A      A  +        
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4401

Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
               EEAS LQ+         Q  + + EQ +Q++    +  +G H EIED          
Sbjct: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461

Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
                 KP+     +  + Q++ H E+    +  +E   SL  K + +  +   +      
Sbjct: 4462 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4520

Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
             ++  L E  E ++ +L    +     + +     ++L   +   +  E T +  S    
Sbjct: 4521 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4576

Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
               PS + +T    +++   +   +++ R Q    ++  + +  + F +          L
Sbjct: 4577 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4632

Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
              +Q  WE +   + E+ R+L +A +R +++ ++   +   +E  E  L    E    P+
Sbjct: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4692

Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
               +Q+A+H+    + L  +  + +  +     L  ++  AD  + L L   L+ L ++ 
Sbjct: 4693 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4749

Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
             TI  K+  ++  LEE L   L   +   ALQ        L  WL   +  L     P  
Sbjct: 4750 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4798

Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
              +D+   L+D      +   K  +  +    +   L+EG   ++D++  +  +++ L  
Sbjct: 4799 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4855

Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
                +      KQ  ++   ++ EE    + A     + EWLA+A  T            
Sbjct: 4856 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4910

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
              ++ + Q KE  ++L E+++ L    + G+ +L
Sbjct: 4911 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944



 Score =  224 bits (570), Expect = 4e-57
 Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)

Query: 500  LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
            L+K +  EL  +L  L    E  S +  W+ K  +  +  Q        +   + +E +K
Sbjct: 2454 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2513

Query: 552  FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
             FE    Q     Q LK      ++ +    EA    + + E  ++W+ L+      +  
Sbjct: 2514 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2573

Query: 608  LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
            LEE  +N  ++    A L+ WL + E              MLN      +   +      
Sbjct: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633

Query: 655  QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
             Q+  +  AG  ++     D  +   +K+QL  +  +W  L  ++       D+      
Sbjct: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693

Query: 712  EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
            +Y   + +LS   ++   KLS  L VS     MN +L     + Q+++  ++++ V  A 
Sbjct: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2753

Query: 762  --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
                  + K  +L  + S Q EG  K       K +  +  ++  C S   ++  S+   
Sbjct: 2754 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2813

Query: 815  IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
              L+  +++    +    K++ + +++ + +  S  L  Q H  ++ +A  EN    L L
Sbjct: 2814 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2869

Query: 872  IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
              +GS+     + L+ +  ++D     +Q+ +     +  ++K   +K+ VET    + K
Sbjct: 2870 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2927

Query: 932  FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
             + +  E++  L  A EG       + L +   + F  ++      N+ L  C+   +++
Sbjct: 2928 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986

Query: 990  PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
             ++ +  +Q+      +LH +   L+          ++  E  R L   +E   +LD   
Sbjct: 2987 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3043

Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
             L  Q  S K +    +  + +      + ++ L + L   L V     D+ GT  V L+
Sbjct: 3044 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3098

Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
             E  A   ST  + +++   + +   +    F + I    +Q      E    A  G   
Sbjct: 3099 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3158

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
              ++       K+ ET+     +L+ L  ++S + A K    +     +   LV +  ++
Sbjct: 3159 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3209

Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
            E   K  +   D  Q +E      +K  LEE  S  KE            + Q    ++T
Sbjct: 3210 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3268

Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
            E + +   +  +  +++ + +  K++DV    Q + Q+           H +L  + +  
Sbjct: 3269 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3327

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
              L +   ++  ++Q  L    RF+   E+++ ++  T    ++++  S +  + + +++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3386

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
            ++ K   +  +      E + +E  +I     P +K  + +Q   +  + + L +  E  
Sbjct: 3387 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3446

Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
             + +E +      F    E L+ W+T  EK L     + T +S ++ QI+Q K    +I 
Sbjct: 3447 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3506

Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
            +    +       QS     +  +   +++KL   + +  E++E +      +   L   
Sbjct: 3507 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3566

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
            + F E+  ++   ++E  DKL+  + +   +TE         +VLQE  D+    +++  
Sbjct: 3567 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3623

Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
            A+       ++    +  +   +  A++ +Y+DI + + +    LE  L   +RL     
Sbjct: 3624 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3683

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
               TWL++ E +  S E  +       + +++  + L+ E  +  +    L ++  +L  
Sbjct: 3684 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3742

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
            +      + ++  + + +ER+R +   I +++  + + +   QQFD+   +   WI    
Sbjct: 3743 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3802

Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
             +L +  +I +   Q +  L   K    E+   K  +  L     K+ +    E+   ++
Sbjct: 3803 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3862

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
             K +   + ++   Q+   R L L    S + +F +++  L   L +  Q++ +      
Sbjct: 3863 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3921

Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
             E + + +   +  Q  + +      +D +       L++   E          AD L  
Sbjct: 3922 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3981

Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
            +++           EA + +     F D+ +++L+S+E I ER  +        + ++++
Sbjct: 3982 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4038

Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
            +     +  ++   +     LK + +++        KD++ A  V  +++++   W++  
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4097

Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
             L+ E + +   +++L  ++           ++ S ++  + T   I+D ED       +
Sbjct: 4098 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4148

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
            K      ET + +++  Q++LD   + G  L++      K I       + +  +S    
Sbjct: 4149 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4208

Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
            W D  +KLEE M   + ++   D + +  D ++  +   +  M+   ++L+   +  E L
Sbjct: 4209 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4264

Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
            K+F+SE   + + +E L+   +  + L K +    D   ++  LM+ KL  +  +E    
Sbjct: 4265 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321

Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
             +  L+       Q +  ++++  W T  E  L          +  E  L K   +Q ++
Sbjct: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381

Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
             + QS + +  +  N L       E  +L   +  L ++ + V +   + +  L  +L  
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441

Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
             K F   +++ Q+W    +     S    G  +  + +L+    +  +    +    ++ 
Sbjct: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            Q+GQ + A   K   ++I + I    E++++   +  + K  L++  +    F +  +  
Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4561

Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
              W+ + E+  N  +           + + HKV  F  E+ + RE + +L + G  L  +
Sbjct: 4562 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4617

Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
                 Q+  L   LL S Q+    +++   E+ RS   A +  +   EA   +  W++  
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677

Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
            +  L          D ++ +L+Q ++     G      +     G     ++S  +    
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737

Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
            +   L  L++ W  I   SV  Q+ LE  +     + +    L  W+  V+ ++      
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797

Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
               +     L+D+ ++   E    T ++  L   +REL E   +D S+     +EL T++
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4857

Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
              +  ++  K  ++E  ++    +   VH   +WL  A++ L     +  D  A +  + 
Sbjct: 4858 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4917

Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
            + KE +   E   + L++  ++   V           +   +  +RA   ++E+ +   +
Sbjct: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4974

Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
               + L S +A       G +A+ ++ LE   A L+ WA+  T L  K  D+E++     
Sbjct: 4975 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5017

Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
             QEI           E++K+ + E   F  +++     V  + K Y
Sbjct: 5018 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5051



 Score =  210 bits (535), Expect = 4e-53
 Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)

Query: 20  RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
           R+ DE++ VQK+TFTKWIN HL K +    V+DL+ED++DG  L++LLEVLSG  LP E+
Sbjct: 68  RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 125

Query: 80  GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
           GR   R H + N+  AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++ 
Sbjct: 126 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 183

Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
                              V+ E+               +AK+ LL W Q       GI 
Sbjct: 184 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 212

Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
            ++F   WR G  F+++IH  RP+L+D+ TV  +SN  NLE AF +AE ++G+ RLLDPE
Sbjct: 213 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 271

Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
           DVDV  PDEKS++TYV+     +P +     +G   +++   +  + N V    +  R  
Sbjct: 272 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 330

Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
              M       ER      +    L ++Y  FK   +      + K K++  L++     
Sbjct: 331 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 384

Query: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
           G++ L Q       ++      +W            G +   +   E ALR E+   ++ 
Sbjct: 385 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 426

Query: 436 EETANTIQR 444
           ++ AN +QR
Sbjct: 427 QQIANRVQR 435



 Score =  162 bits (411), Expect = 1e-38
 Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)

Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 1049 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1106

Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 1107 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1166

Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 1167 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1211

Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1262

Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1322

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 1323 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1382

Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 1383 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1442

Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 1443 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502

Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562

Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1622

Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 1623 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1676

Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 1677 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1736

Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
              W+   ++  +     H                                      + T 
Sbjct: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796

Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856

Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916

Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976

Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2035

Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 2036 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092

Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152

Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2267

Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2326

Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 2327 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384

Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444

Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504

Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564

Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2624

Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 2625 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684

Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 2685 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2740

Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
                    V     E     DLS  ++    +A  S   EG  +  KD   +    +   
Sbjct: 2741 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2795

Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
             SA  S  Q +Q+ +   A  D++ + Q   + I +K      L   +K + K L   S 
Sbjct: 2796 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2855

Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
              + ++   E+ L + + S    + L     +T      W+    Q   +E ++K++L+K
Sbjct: 2856 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2910

Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
              ++   + ++W W+   +  LE+   ++   D    E  I KLK LQK +D    ++  
Sbjct: 2911 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2967

Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
            +N  +         +   + D    +  + D V   L   +  L++   + + F E+S  
Sbjct: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027

Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
                L    E +D   +      SN    +LQ   K L  +KH++    L     QD+  
Sbjct: 3028 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3084

Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
            +   +++GT   +   +V  I      L ++V      LE KL  +   Q  +    S  
Sbjct: 3085 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141

Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
                DELD+   V    GR     QK
Sbjct: 3142 AEFDDELDSMAPV----GRDAETLQK 3163



 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)

Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
            DL++W   +Q   DR E W     +V   LE  ++   A  EF      +SSLK + +S 
Sbjct: 650  DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 702

Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
                  LK     T   +L R++SQ+  LL N    QE+ H   +    SR A +E++ W
Sbjct: 703  IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 754

Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
            ++      +K+E+ +  +  +   +  + + K +  ++  +    +   +SV +I+ Q +
Sbjct: 755  LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 806

Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
                  +        AM   W  ILQ     +  + E    ++ E+ N+ +    +    
Sbjct: 807  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 864

Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
            +  +++++     +S+         LEDL++   +E E++ Q  + +A +  K + +  +
Sbjct: 865  KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 917

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
                     +T   +  +    +I +    D       +SH+  +  I+    EA     
Sbjct: 918  KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 977

Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
             F +   + EAV +      Q  N+  L  +     +S+  +  + N++ +     V   
Sbjct: 978  CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1037

Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
             T         L  +  R+ + LE+  E Q+ S   + QL        Q Y++  K    
Sbjct: 1038 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1097

Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
              Q++                    EDR    ++    +D   + V   I +   L K L
Sbjct: 1098 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1156

Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
              +KD L  +    E+   Q  A+A+S++ + +  L+  L  + Q      T +   +  
Sbjct: 1157 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1213

Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
                 K+ +A EA +      +  EE +     +  + +ST+++   E+  +   F ++ 
Sbjct: 1214 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1273

Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
             +L +   +   +    KE         ++   L   W  +  Q   R   L+     L 
Sbjct: 1274 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1333

Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
             ++      + W++ +  T++K+      N + L  Q    ++  +E+  +Q    S + 
Sbjct: 1334 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1389

Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
            + Q+  EQ     +D     +T                R ++DSQ +   + R M     
Sbjct: 1390 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1434

Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
              + E   L       V +  Q  +   D ++  E+                        
Sbjct: 1435 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1470

Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
               E +L+ E  E  EK K     L++    ++  LKD EK  K        S E++ T 
Sbjct: 1471 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1524

Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
            K++LS++L      L  H ++M  +E             Q+  L+++ +   S       
Sbjct: 1525 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1572

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
                 L Q Q  +    + +  + + ER  E   + EK + +C+ LTQ E+++  +    
Sbjct: 1573 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1624

Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
              GD  +E        E+L+KD Q        + +  +  L++ GE+L+   KA  E K 
Sbjct: 1625 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1684

Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
            +E + K  ++N + +     L  ++   +K+  E + AV+QL+++   + +L  WL++++
Sbjct: 1685 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1744

Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
              SE A    K ++             S   EE                   Q  LN+Q 
Sbjct: 1745 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1804

Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
            +      ++ I +H   + +  +  +VLL       +  E + +Q+  + L   +    A
Sbjct: 1805 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1863

Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
             S E+++K+  + +   +KF  DY+ FE WL+ SE+      +          +LK+ ++
Sbjct: 1864 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1922

Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
            F   V      L  I     R+             + D++ +   +++ +     R+ +L
Sbjct: 1923 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1982

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
              +   +   LK  + + + +E A   +L  L     + T  +H SE       ++Q ++
Sbjct: 1983 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2040

Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
            ++ KA Q +IS     +E++    E L++    L  A   I++ LD++    +++   V 
Sbjct: 2041 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2100

Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
              ++KL ++ L         R L ++D      L W      SL      P  S+ L   
Sbjct: 2101 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2150

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
            +++ +  E+      +S+++          ++  ++  M    PS     Q   KD   R
Sbjct: 2151 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2200

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             +   S  H    +++ +L   ++      ++ +  + +KT    E+D   K   +L   
Sbjct: 2201 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259

Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
               S      LEHK   E   SL   ++ H   +  A V+++   L  +    E  +K+ 
Sbjct: 2260 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2317

Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
                    ++   F   + S+ +W+ +T ++                LE  ++L+    +
Sbjct: 2318 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2377

Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
            +T E+Q        L  L  AV      I ++     + + E T  +++E         +
Sbjct: 2378 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437

Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
            +  ++ ++  ++ +  LL++    L   L + Q   E S  ++  L+ +++   +     
Sbjct: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497

Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
            +  D E ++   +Q    + EL ++  +V  L+D   +LL   E  D  EA         
Sbjct: 2498 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2547

Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
            R K +L E+    +EL +L       L+ SS+        +  L  W    EL  S  + 
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2606

Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
            P S    PN   T R +  +     +   P            LS PG   S RG +   L
Sbjct: 2607 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2664

Query: 8746 RA 8747
             A
Sbjct: 2665 AA 2666



 Score = 54.7 bits (130), Expect = 4e-06
 Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)

Query: 366  EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
            E ++Q L   G+ SLD A  + + +    S+L +W  + +KSL + L          E+A
Sbjct: 4640 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4688

Query: 425  LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
                           + I+ +L QHK+  ++  A     H +Y T +  G  +       
Sbjct: 4689 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4732

Query: 479  ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
                   D L ++ +++  +   S        E  L   +F +    L+  L   E +L 
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792

Query: 525  SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
                 +G  + V  L+ N+ +F    K   +   + Q LK++A   +  +GS +++  V 
Sbjct: 4793 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4847

Query: 585  KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
              M E + +W  +     S ++ LE  +   + + + V +L  WL +AE+      +L  
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907

Query: 639  SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
             E+A        K+F + L     +       G+ ++  C       +K  + ++  R+ 
Sbjct: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967

Query: 692  ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
            E+    KQ+ Q  A  +  +  K+E  + ++    +A T    K  E +      VK LI
Sbjct: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027

Query: 747  QD----LEDIEQRVPVMDAQYKIITKT 769
             +    +E++ ++ P +D     +TKT
Sbjct: 5028 AEHQTFMEEMTRKQPDVDK----VTKT 5050



 Score = 33.9 bits (76), Expect = 7.3
 Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
            Q +QL+++      A + +E+  LR  C  V+ +      +  +L +      L+    +
Sbjct: 498  QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 552

Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
                +  S L        SL     SS+++  L+  + S  +   TPA     P      
Sbjct: 553  TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 601

Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
              L  +  S +      E    Q  K   +R  +  S   D +  E +I     + L   
Sbjct: 602  -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 654

Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
            +D+ + Q+ +TE    S  P+      ++K   + + E  SS+      E K+ E + + 
Sbjct: 655  VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 707

Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
            P        +   A  + R E   A+ L+     +++L     F S   +   WL + EE
Sbjct: 708  P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760

Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
            E       E++ D       I + K    EL + +D ++  I S+   + +    +    
Sbjct: 761  E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 813

Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
              ++   + M  +W  +  L +     +++     + F++       L  L++  +RK  
Sbjct: 814  LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 871

Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
                D +     L+D  ++ M+ K ELL+ +  +A+L   +  ++ +    +DC
Sbjct: 872  -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 924



 Score = 33.5 bits (75), Expect = 9.6
 Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)

Query: 375  DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
            D  L LD  L  ++  WD +  +  +   +L+++L         L  +  WLYR E  L 
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792

Query: 427  EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
            E+  V    +   N I       K+L + T    A KR+  E+      +   V   Q++
Sbjct: 4793 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4851

Query: 484  DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
            +++ R+  V + S     ++        EF  + + LL  L  AE  L+   +     ++
Sbjct: 4852 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911

Query: 536  VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
            +  L+  +  F                +K+  E   + + +    + V+   +     T 
Sbjct: 4912 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955

Query: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
              W      +  +R+  EEV++   ++   +AS  A L            AK++    L 
Sbjct: 4956 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4998

Query: 652  HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
             W+Q       A   L +   E++ +++++   L+     + FME     Q D +D++ K
Sbjct: 4999 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5049

Query: 712  EY 713
             Y
Sbjct: 5050 TY 5051


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  372 bits (955), Expect = e-102
 Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)

Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 1463 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1519

Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1578

Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
                T    +V    +Y+   G S +R       +SL  E ++  E +K  +        
Sbjct: 1579 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1636

Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
             +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D   +
Sbjct: 1637 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1690

Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
              E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L  +
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
             ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K   
Sbjct: 1751 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1807

Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
                 EDK  +  K+  +     K  Q ++   Q+ + L   +T                
Sbjct: 1808 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1849

Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
                A++++ E +  +++ +E +T +ENLL     ++K+           +    T  + 
Sbjct: 1850 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1905

Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
            G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+  
Sbjct: 1906 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1965

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
            +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD  
Sbjct: 1966 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 2023

Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
               F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+   
Sbjct: 2024 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 2083

Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
                        K+ +     ++      A D F+       V+      L  L +  Q 
Sbjct: 2084 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 2140

Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
            +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ + 
Sbjct: 2141 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2199

Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
              A+  L    S    +   + T D + G  E +   +  +  +         + QD  +
Sbjct: 2200 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2259

Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  + 
Sbjct: 2260 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2319

Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
             D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  + 
Sbjct: 2320 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2379

Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
             + T   +  KD  +L               Y Q+    F    KHL    S LK+I S 
Sbjct: 2380 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2425

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
                + +D    ++K  ++S+K +E  D ++      + V S +++++ +        + 
Sbjct: 2426 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2479

Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
            + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   + 
Sbjct: 2480 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2538

Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
            TP                AK I  V  G  + +    +T  E+F  +     T +++ + 
Sbjct: 2539 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2580

Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
            + +       L  +KD   EL ++ S +   QE  +++ +        +     T     
Sbjct: 2581 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2639

Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
             EAV     KTQ    +S E    +++ + QE                     L+ KL +
Sbjct: 2640 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2673

Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
            L                + +   T  A   KQ+       +T+ + ++Q   +  +  +Q
Sbjct: 2674 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2710

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
             L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E  
Sbjct: 2711 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2768

Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
              +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A+ 
Sbjct: 2769 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2828

Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
            +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K+ 
Sbjct: 2829 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2888

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
             A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +  
Sbjct: 2889 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2947

Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
               + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        + 
Sbjct: 2948 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2998

Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
            IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + V 
Sbjct: 2999 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 3057

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
                W+                    Q  L +IK  +D  E G + +++++SL  E+ Q+
Sbjct: 3058 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 3099

Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
                  EL++    +L +  +  ++ V      L   V  +          +  + Q  +
Sbjct: 3100 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3157

Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
            +F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R +
Sbjct: 3158 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3217

Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
            +DL   +    G          + +E++ L  Q  + C   E  LQ         +    
Sbjct: 3218 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3277

Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
             F +F   L +          + +    +   L+K++  ++ ++N      MML+  E  
Sbjct: 3278 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3337

Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
              L+      GI+  + A  +           +E  +E    ++++F    +     L K
Sbjct: 3338 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3391

Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
             E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    +A
Sbjct: 3392 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3445

Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
            +KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D   
Sbjct: 3446 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3505

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
            ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I +
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3565

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
            QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E    +
Sbjct: 3566 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3625

Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
                   + + K L +++++++  L      G  +       +  + Q +L   Q  Y  
Sbjct: 3626 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3685

Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
            IQE++       ++ +   + +  D      WL +  +KL + SV +         ++ L
Sbjct: 3686 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3745

Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
            R LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++  
Sbjct: 3746 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3803

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
                  +   R +    +++  WL   E E +S  T+        + Q+   ++KK  + 
Sbjct: 3804 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3863

Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
              A  D + EV +   E++      +R G +    +   RY+ +   + ++++ ++  I 
Sbjct: 3864 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3920

Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
              ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     +   
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3975

Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
            ++    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +F 
Sbjct: 3976 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 4035

Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
            +  + L  W+ E Q I+     P +E    + Q  +++ L++ +  H+P +  + + G  
Sbjct: 4036 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 4095

Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
            LLEL   +  ++++K     + Y  +    K+   +L+  +     ++ ++ ++ + L +
Sbjct: 4096 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4155

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
            +  RL  P  + ++ +E I +Q++ +K +  ++   +     L+ +G+ +I +       
Sbjct: 4156 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4214

Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
              A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T++
Sbjct: 4215 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4267

Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
              Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +  
Sbjct: 4268 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4325

Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
               VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L +M
Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385

Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
                ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   + L
Sbjct: 4386 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4443

Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
             +    W  L  +  N   + E  L     +   ++ +  +L               +  
Sbjct: 4444 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4503

Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
            A+ +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  + 
Sbjct: 4504 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4563

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            +  +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H+ 
Sbjct: 4564 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4623

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
            +C+  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  L 
Sbjct: 4624 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4683

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
            +AL+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++ +
Sbjct: 4684 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4743

Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
            +  L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F E
Sbjct: 4744 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4803

Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
             + K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+++
Sbjct: 4804 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863

Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     L 
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4923

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
             +E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R   
Sbjct: 4924 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4981

Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
              W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+  
Sbjct: 4982 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 5038

Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
                LP +E      +  +      L++    L + T   + +     P +    +H I 
Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 5098

Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
              +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + + 
Sbjct: 5099 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 5153

Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
            I +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD     
Sbjct: 5154 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5212

Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
              R   ++L    SQ Q             ++ QV+  A       ND L+  +EL + A
Sbjct: 5213 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5272

Query: 5020 GNGLDV 5025
                D+
Sbjct: 5273 NFDFDI 5278



 Score =  340 bits (873), Expect = 3e-92
 Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)

Query: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 1290 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1347

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
            K++ + L   +L     AE+ +K +  K    E+V   +  ++N +S +        E  
Sbjct: 1348 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1404

Query: 551  KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
            + F   E        ++ ++ K   E  +  D   E+A+ +++       +W+N+ V++ 
Sbjct: 1405 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1457

Query: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
            +    LE +  +   Y +T   L  W++  E        NQ EN+K    + N    +  
Sbjct: 1458 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1517

Query: 657  HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
               M  +     +   E  S  +K   L       +++ + +     VK+       D +
Sbjct: 1518 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1574

Query: 710  KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
             +E+ D     +A  T     +++ ++ +  ++K L ++ + +E+       + K + K 
Sbjct: 1575 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1630

Query: 770  AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
               I+K  +  ++ GK  F+      E+++  KE  S  L   Q  L             
Sbjct: 1631 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1690

Query: 819  ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
            ELEKQ+ +  +S   +        +E+Q+S   K + + +   Q+  K+ L         
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750

Query: 871  ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
                        +I  G+  ++K+ +    L+  D     + +A++    ++ +K+ G+ 
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1809

Query: 919  -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
                 K  +E           +L  K E+S+ EL+KV+  A +E  E+    ++L    T
Sbjct: 1810 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1869

Query: 965  EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
            +  + LD      +L   D+ ++    + +Q +++     H Q  D       + E   +
Sbjct: 1870 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1921

Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
            LL   +D +    + + +E   +  ++ K       EKII +H+ V  + +    L EK+
Sbjct: 1922 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1973

Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
             Q +  EE   K  ++  +++        L E    +  T+  L E+ +K+  DYT    
Sbjct: 1974 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 2025

Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
            EF  W+  +E +L+ ++  A D      ++KR      + ++ +G+      S  +VL  
Sbjct: 2026 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 2085

Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
              S         + +    +   KL  +     +L S+   + +N  D V   +  +++ 
Sbjct: 2086 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2145

Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
              L++G +  +  A K L +E +    + L    ++TK +  +    Q  + + ++    
Sbjct: 2146 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2204

Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
            L D     L     ++ TLD        L +S   +  ++Q+TL +    +   + ++ +
Sbjct: 2205 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2264

Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
            +    SS +      L+ ++L+  +S  +   ++ + R  SI    E  VK+  E    P
Sbjct: 2265 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2322

Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
                 LQ + K +  +  +     +E +  ME +KTK + F +  E L  ++  K + L 
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2382

Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
             ++     +      ++ +  E       +  L    +  +      + A +  K   + 
Sbjct: 2383 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2442

Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
            +  +E+ +  +  +  +     Q   F+  ++ ++  + E                    
Sbjct: 2443 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2502

Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
             ED   +  K      E  KV    + LC  + ++++   A +A  S   V+N +     
Sbjct: 2503 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2562

Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
                       S  ++   +   YED+    K++   L   L+  Q+ ++E S+ + WL+
Sbjct: 2563 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2622

Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
            +    A+  +      D  A + +VE        L+  V        KL +L E      
Sbjct: 2623 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2682

Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
                 K M   L ++D +W++L Q+   R   L+       QF  +      W+   +L 
Sbjct: 2683 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2739

Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
            +S L   S           ++ I+  + A TR   +         + S+ GE  SL+G +
Sbjct: 2740 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2797

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
             K       +    L G+  D     ++A     + Q  L  L+                
Sbjct: 2798 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2857

Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
                    + L++   +   ++Q ++ ++   ++ ++ S L++++   A + ++ LE   
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2916

Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
             S   +  KA+ H+     +   S  A++ Q        Q  L TK+ E +        L
Sbjct: 2917 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2971

Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
             VL+   +D K+  + L +   + E+T  E      + +   + ALQ +L       D  
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 3031

Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
            N      E++L    +KA +  ++     P +D+  N LE      D  +        + 
Sbjct: 3032 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 3091

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
            + +   Q  G+++L+    N   +V +     V +   S+I     + +Q        E+
Sbjct: 3092 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3151

Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
            +   F + +     +K ++   ++ LD   S G    S                     +
Sbjct: 3152 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3211

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
            L K  + D  +  +D + T D  L V E + +    L   +      L T+ +  G   N
Sbjct: 3212 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3270

Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
             + +M    +  D+ L       R  E L++ +  +K    +LE L +  ++  +  K +
Sbjct: 3271 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3330

Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
                ET PDL  I+ DL    +   ++ + A+       A+  QVE  I  +  +++K++
Sbjct: 3331 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3383

Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
            E    L    ++E  +             L   K  QKE    LQ +Q +++   + L  
Sbjct: 3384 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3443

Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
               K  S   + L   +  +  + + +++  ++  A LQE+L     F ++++    W +
Sbjct: 3444 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3501

Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
              +         + + KV++A++ + + +   + D +S ++ + +EG+ +          
Sbjct: 3502 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561

Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
             I +Q++  +  ++A L +     + L+  +     F +    LN W+  +E+R  N E 
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621

Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
            +G     + E+       ++++      L + ++  +SL  LS R      E     Q  
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3675

Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
               SQ+   +  +   +  +    Q AL   +   E    +  W+  + D+L+       
Sbjct: 3676 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3733

Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
            S + L K+ S++    +DILL K      ++ A+  G + L+ +  +   +IQ +LE +K
Sbjct: 3734 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3789

Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
              + DI   S     TLE  +           +L  W++ V+ ++          E   Q
Sbjct: 3790 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3849

Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
             Q   KE      + +++L    + + AL  L+  ++RE  EK   E            +
Sbjct: 3850 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3900

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            +  +     +K+ +++  +     +  A      W+   +++L    D+  +   T  +L
Sbjct: 3901 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3960

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
               K    + EI   +         ++  +   SG ++M    +  +   K+  D V + 
Sbjct: 3961 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 4009

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
               +  + S+  L  +     V Q  +  E+    L      ++ L     + E + +  
Sbjct: 4010 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 4069

Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
             + +++ + + + +P  + +     +L   S       G+   + ++Y   + L  Q  +
Sbjct: 4070 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 4123

Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
              + +   L +   ++   F   +     +  +  +  +    +S  ++KI+E +SE++N
Sbjct: 4124 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4182

Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
                +  +    E L      ++ +         AK +Q K+      W+N H+ + ++E
Sbjct: 4183 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242

Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
            + L ++    + F      +   +  T+  + +  +   D    +++Q+  +++ EEI  
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4302

Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
             + +L+ +     +L    G+      +  + +L+S + +L+   K+++ +L+  +    
Sbjct: 4303 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4362

Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
            Q+  G++ + DW+  A   L S     +D   +  +  +L+   S   +++I+M+ +  +
Sbjct: 4363 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4422

Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
             E +L+  + E    T+Q  L  +K +W SL    I  + +LEGAL     +Q  + +  
Sbjct: 4423 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4482

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
             W+   E  L+E +    + +     L K  +L  +VL++ S +E +   G  + E    
Sbjct: 4483 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4542

Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
                  Q +L+ L +R++ + E+ ++   + +  +R  + +  +++  + WL   +  L 
Sbjct: 4543 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4602

Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
                L G   T +  L    E+       +    S++   + ++      AE   D+ + 
Sbjct: 4603 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4662

Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
            +L++ W++ + +L+E +T+    +N         Q    WL  AE+ ++  +R      T
Sbjct: 4663 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4722

Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
               Q+ + K +  EV ++R+++ E+      +   S     +  +     + SR++ ++ 
Sbjct: 4723 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4782

Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
            +++E+ + L++  +  ++   + S   +W   + K+  +   +A   DK+ T     +L 
Sbjct: 4783 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4837

Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
              +   K +   HS+  +    G R++K       + L+  + D + +L++   T+    
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4894

Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
             +    LE+ L  + +F+D  +AL  W+   +  L   +    ++      +  +K+ Q+
Sbjct: 4895 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4954

Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
             +     SV++++     L+E  +D +  +K ++ +L + ++ +C++       LEA ++
Sbjct: 4955 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 5014

Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
              E+++S +  + +WL +    L    V PD  +  +L T+  Q   HK  M+++     
Sbjct: 5015 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 5069

Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
             LN     GDT++  C       +K  +       +  +  + + A++  Q L   L   
Sbjct: 5070 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 5125

Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
            +++Q+ L+   AWL   +  L    +  +      ++++  +AL  + +T+++
Sbjct: 5126 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 5173



 Score =  320 bits (819), Expect = 5e-86
 Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
            HQQ    + ++  D  +   ++Q   G    +  +E+   +     L +S ER+E+   V
Sbjct: 1183 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1242

Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
                   +R    R E  ++ ++R +    +    HE     +  E L  ELE+ K+   
Sbjct: 1243 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1299

Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
               +I  + E    +A+     P  +  L    +++  QV  +  T  + +KT+ +V   
Sbjct: 1300 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1358

Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
                 +  +     + E+E    A+    + ++  IS +K    E++ K      LE+E 
Sbjct: 1359 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1414

Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
            Q     S   F T  E                        +I  +L  +   G+ L+ + 
Sbjct: 1415 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1474

Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
                 L+  I       Q+ E   RKIQ++  E    LA  +          ++ Q  MD
Sbjct: 1475 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1527

Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
             CQ   E  S+ +  +            +  +  V R      A  + Q++ D+    + 
Sbjct: 1528 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1583

Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
            R TAL  L+  +        +RLE+E  S     +    KA   +  +S   +   + E 
Sbjct: 1584 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1643

Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
                    + +S     +K  QL E+L ++         +L L +  ++  D      + 
Sbjct: 1644 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1688

Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
             N L+  V   Q+   LL S S+     L E QT+ ++ + + ++   R +++  +++  
Sbjct: 1689 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1744

Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
               L   +  L     +G  E   +  G  E            +++ Q     L + +Q 
Sbjct: 1745 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1787

Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
             A +L+ +++     + E    +++ +  LIE+ LN+A    + L    E +   LD ++
Sbjct: 1788 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1847

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
            + A         ++ T   A   QL     +I+NLL                        
Sbjct: 1848 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1899

Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
            GT   E D     K A  ++ E    LL++  D +  T +E L +  ++   Q  ++ +Q
Sbjct: 1900 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1955

Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
             +  + + +     L+ + + ++ ++     ++ + +  L+V ++          +L H 
Sbjct: 1956 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 2012

Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
             Q +         E+++      + LEN    A  +    T +K Q+        H+   
Sbjct: 2013 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 2070

Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
                    DL   T  G  +L   K     D   V T          +V  KL+   DR 
Sbjct: 2071 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 2117

Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
            R   S  +       D++      E  S   +  +    +    HL            R 
Sbjct: 2118 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2177

Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
             E  K  + ++ ++ + +E+L      L +   +L     D+Q    D++ + E   +  
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2237

Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
                  L+    +S  V+  ++++  W   VE SL    Q   N T   + + K   +++
Sbjct: 2238 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2297

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            ++  +QS+I++  E +         +   SL   M  L  +    S    +T A ++E  
Sbjct: 2298 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2357

Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
             K    E++ E  + FL  K  A    D  G   V E   + +Q       + +  L+ +
Sbjct: 2358 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2415

Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
                + + +H      + + E+    +++F+       + K+A+  C  +L +F+   + 
Sbjct: 2416 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2475

Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
            L  WI E  ++       F  E+LG+S +   +       K  E+ KV    + L  L++
Sbjct: 2476 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535

Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
            A     +++  +   G +L+ EG     E    ++ LTS           +++L  + K+
Sbjct: 2536 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2595

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
            K+      L + +  +E   +M  W++ +       + T    DT   +    Q+     
Sbjct: 2596 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2652

Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
             E E+K N+  + + +  L    +E     +       L  +   W ++   ++  Q  L
Sbjct: 2653 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2712

Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
            E   +    +   + QL+QW+   +  +    PL   P +         +Q +L E    
Sbjct: 2713 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2770

Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
                 +L A  + +  +  ED S +   +E+L   TQ  D +T    ++   +++ +   
Sbjct: 2771 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2830

Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
              Y   +   +D L     +L     +S    A  ++L    K+K+ I  + ++I  ++ 
Sbjct: 2831 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2889

Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
            +  E L+  VK+       E +  E+ + L    K ++D   + ++ +++L S  A S Q
Sbjct: 2890 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2942

Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
                     +Q    F A L T  ++          L +LE    D +        Q  +
Sbjct: 2943 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2994

Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
                 AE     LK+Q +E       L+T         K+            + +E  L+
Sbjct: 2995 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 3043

Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
            +   KA +  +Q      W+   +    +   C D  +  + ++   SLQK + +     
Sbjct: 3044 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 3103

Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
            E   +  N +LS  E+   ++T E    IQ KV    E        LH K+  LEN+  +
Sbjct: 3104 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 3155

Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
             K+F EVS E  +      E++ +H+S   L       +    LQ+  + +   + Q++ 
Sbjct: 3156 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3212

Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
             K  AQ L    + SK       +V  ++ ++  LS    EK S L+  +     F   I
Sbjct: 3213 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272

Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
            +E+     +    LDS      D   L  +         KLEAL++         KM++ 
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3332

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
              E     TSP+ +  I++ L+++      LL      + Q+EG + +   +   +++FS
Sbjct: 3333 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3386

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
              +   E +         E       L   K+   EE+       + +   G G+     
Sbjct: 3387 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3446

Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
              T     + +L D+  R++ + ++  +   + ++ +     +Q  L++   W+   +E 
Sbjct: 3447 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3506

Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
            +        +    +  +++ + LQ    + ++ +  +    E +  +  P  + + L+ 
Sbjct: 3507 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3566

Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
            L      W+A  ++      Q   +    +   +  + ++EWL T E+++       +  
Sbjct: 3567 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3626

Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
            +  E Q+ Q K   +++  +   + +  +  Q +       D+  V S++        + 
Sbjct: 3627 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3686

Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
             + +     LL Q L   K F E+E++ +           +W    H     ++  +   
Sbjct: 3687 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3733

Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
             T  + K+   L VL +D+      +  A   G   +K     E   ++ ++     + K
Sbjct: 3734 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3793

Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
            ++T        TLE+ L LA+      + L  W+ + +  L   E   ++  E      +
Sbjct: 3794 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3853

Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
             K L++   +++  + S+ E   ALLELV       L+  + +    Y+ +     + V 
Sbjct: 3854 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3913

Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
             ++A +   + ++        W+ +   +L++   +     +T + QL   K    EI  
Sbjct: 3914 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3972

Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
             +D +++L   G  ++  C++  +  +K+ +   L+    +Y  IC      Y  LE   
Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 4028

Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
                   +T ++   WL+  Q  +   P P L       + +  R  QE+ R   +L+  
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 4081

Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
                 +   KT  + ++ +     +I++K V A  L   + +IK    +  + L +A   
Sbjct: 4082 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 4138

Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
                    DQ L++++R    L        E+   +  +S+ K+    ++  Q    T+ 
Sbjct: 4139 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4198

Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
            ++  ++  +    +     K +    DQ + +    + L  +RE    D+    +   C 
Sbjct: 4199 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4258

Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
            ++  +   K T ++      D E   +    +K+   A +  +  I+ L+++        
Sbjct: 4259 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4314

Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
             ++I      DK +VK+    L   W  L    K +I      ++     Q   Q + +W
Sbjct: 4315 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4374

Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
             +     +A                E LKQ       Q + M+ L   +EL     LLK 
Sbjct: 4375 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4429

Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
            + +++D+            +Q  L + +   + L + +  R+  L  AL    QF  A+ 
Sbjct: 4430 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4479

Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
            +  + +   E  +  ++ +   P  +  ++      Q  +  +Q+ V  +   G +L++ 
Sbjct: 4480 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4539

Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
               +E S +  KL+ L   + +VL+K   R Q+L+  L   K F  + +    WL   + 
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599

Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
                   L         QL  +  +       E    +L + GQ +L    +   + + +
Sbjct: 4600 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4659

Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
             +N L  ++  +     ++  K++EA+    E+ + ++     L++ E Q L ++  P+ 
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4717

Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
            L ++  L   D  +   +EV    E + EL++     +   Q        + ++ + + +
Sbjct: 4718 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777

Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
             ++ ++  +R   L+D    A Q HE   K+ + LE   KS+  E    N+    +T  A
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837

Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
            + K     L   HS+  +   +G  LK  T   +D           K    +   + +  
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4888

Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
             +     E   + E  ++ S  F   +   +DWL RV+ +L+   PV+ D++L  +   I
Sbjct: 4889 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4946

Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
               +  Q+E+      + AL    +E    +++  S+ ++  + ELS     +     ++
Sbjct: 4947 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 5005

Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
            Q  L     Q + ++ V  A  +WL +A++ L+  G   D E A   L   H EF    +
Sbjct: 5006 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 5065

Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
            +  + L +  ++  T+  +  P             +   E+ +A  +   QR++      
Sbjct: 5066 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 5125

Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
             A+ +LL+   A  QW +     K +E + + + + +  ++E   F    T    + ++ 
Sbjct: 5126 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185

Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
               +K   +  +S    I  L++         AS L  +G+     T +  +  +  +W 
Sbjct: 5186 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5245

Query: 5194 RLRAVAQDQEKILEDAVD 5211
            ++  +A ++ + L DA+D
Sbjct: 5246 QVWLLALERRRKLNDALD 5263



 Score =  318 bits (815), Expect = 1e-85
 Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)

Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
            V+    W+D M+  L+ +E   ++L    + L   K ++  +  + S L+  ++    MT
Sbjct: 786  VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 844

Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
                  L+L   ++ +R   + AK   T   +   L  LH    R      +WL +++E+
Sbjct: 845  ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 899

Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
               Y   E + +       H   +R+L + + +    Q +   +L       P+ +    
Sbjct: 900  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 956

Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
             RA    +  W     Q  +  + E    F              ++  ++L+  ++ +  
Sbjct: 957  YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 1008

Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
            +    R S+    E  + +  +  EE+  Y+  +  +  +A+ I+     NS    + + 
Sbjct: 1009 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 1068

Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
              +    Y+ + + + +  + +        + ++ S   +E+ + S        +K   +
Sbjct: 1069 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 1128

Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
            +A +I++       + + TL     + +K +   H L+      R     ++K +  GE 
Sbjct: 1129 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1183

Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
            ++    L+    D +E  +E       +   LEK +++ K++             YQE+L
Sbjct: 1184 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1230

Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
               E  + E       +S+ ++++  + + E   ++ +R      +  E++  + +   L
Sbjct: 1231 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1290

Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
            K ++++L+ D   + +  +E  FS  A         SEL  V + + Q   MS   +  D
Sbjct: 1291 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1347

Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
             L+T +L     Q A      +   + EE A   D+ NN++    TL  Q    +  K +
Sbjct: 1348 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1404

Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
            Q  HA L+       AI     + Y+  + +   H  + D L   + W +  VQ D    
Sbjct: 1405 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1459

Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
                L   E I K +K++R        ++             V+TT + IQ+ +    +T
Sbjct: 1460 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1504

Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
            +  +L Q + L     EI+  +S++    + A+Q    +K    EL+    + MV   + 
Sbjct: 1505 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1559

Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
               K +  Q+S + II++   L  +     +  +  L  Q++     S     + E+ L+
Sbjct: 1560 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1614

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
              +  H       V   K   +W     S+   T    E   K   + Q  K + E++  
Sbjct: 1615 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1661

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            +K+++ E L      L K      ++   +LE  +K       T  E  N++   F E +
Sbjct: 1662 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1711

Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
            +  +E Q +    +++    +  Q        IC  L   +     LI   +  M   G 
Sbjct: 1712 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1768

Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
             E +  Q                   +++ L K +    Q L  V + T    +   + +
Sbjct: 1769 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1810

Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
             +E   L+   +++    C+  Q +LK  Q++        +EL K VT     E EK   
Sbjct: 1811 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1860

Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
            + +L+E ++  +++L       K S R     K ++ +   HF+E        + D+   
Sbjct: 1861 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1920

Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
             L + D+         N + +     A+++ I+ Q        ++  + L++ GQ + P 
Sbjct: 1921 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1980

Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
              E     L + +  L   +   +A ++ K    + +QE +        E+   ++ + Q
Sbjct: 1981 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 2036

Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
             L  LEA    ++ + T L       E+ +S +   R I      + EA    +++  G 
Sbjct: 2037 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096

Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
              T    +    K+ H    +  L  +     + L+D    YQ +E     L   L++ +
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156

Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
               SK   E +  + K     L+   +L G +    +    LK+    L D    L P A
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2215

Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
                +  +    G  + L+ ++ E   + +  + +S+  Q  +   LDW+  V++ L   
Sbjct: 2216 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2275

Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
              + LN   +Q+ I K  + ++++      +NA++ K K+         ++ L+  + +L
Sbjct: 2276 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2335

Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
            S    +     +   A + E+ ++ + +  + +    +LE   Q L ++   G DV    
Sbjct: 2336 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2393

Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              L  +M+  ++E   H  +LE LHSL+  +     P+ K  + +K  +L  + + M   
Sbjct: 2394 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2451

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
               + + +  C  Q   +Q   + +   + +T KK+      F       S E  +KL E
Sbjct: 2452 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2511

Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
              +L                  +S V +  + I A++   + L  E T  +  +   ++ 
Sbjct: 2512 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2571

Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
            +T++ +  T +    +D   +L+D + E     +K++KA E    M+  LQ         
Sbjct: 2572 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2631

Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
             + P  +  +A K    T +E + +F  EL+Q  + +  L+ +   +L++   P   E P
Sbjct: 2632 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2685

Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
               Q +T +  +   + +      + +++   +    +T    +K W+ E +     LG 
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2745

Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
             +I+   ++ Q +++QILL E    +   E++    +    G+ +    + SL      Q
Sbjct: 2746 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2801

Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
            LA V      +  Q+ D+   ++Q+   S     Q Q L + L+  L+ L  K  + +  
Sbjct: 2802 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2857

Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
             T    + ++L+       E+    ++             L +   L   L++++  + +
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2917

Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
              +   ++AEN +  L  A +   ++ +M      W++  K         N +  +  + 
Sbjct: 2918 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2971

Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
             + ++L+++ K+    L A +   +   +    E  +  +   G E   L+  +     N
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 3027

Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
                 K +K+ E +LK+   +LE+A           L  KEQ+   + L   ++  +  +
Sbjct: 3028 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 3070

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
            + ++ C       E+ +A L        LQ+E    QH  + +       +++    +  
Sbjct: 3071 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 3121

Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
            E    E K L Q ++    ++  K     N+       QE+  +  R  + A++     +
Sbjct: 3122 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3181

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
             + S     K LTM       L  +     LA+              GT D+  ++    
Sbjct: 3182 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3241

Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
              H ++      +C  L + +      + T  E+ S  A       S +PV     ++ +
Sbjct: 3242 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3301

Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
                  A+ + L A     D A        + E   P L       L  L +    L + 
Sbjct: 3302 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3360

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
               ++  +   ++R +++   L+  S     I L+ +E  E  + P   E++    Q  M
Sbjct: 3361 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3415

Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
             ++   ++EI  LQ        L + L+  + ++   +   L+  L  +  R  T+  K 
Sbjct: 3416 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3472

Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
            + +   L+E L   L   R + AL+        L SW++ T+  +     P  E   ++A
Sbjct: 3473 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3522

Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
            Q         L+D +   VE+                KV  L +LS+ +     L  KA 
Sbjct: 3523 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3582

Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
            T++         R+L+G  +  Q+  H+  + LN   T  EK   + +   TQ+  ++E 
Sbjct: 3583 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3632

Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
            +AQ +          +   K L Q ++  +SL + ++SR ++ ++Q           E  
Sbjct: 3633 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3687

Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
              +  + ++L Q L     K   ED++  M W   +H        Q++ST+    Q + L
Sbjct: 3688 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3745

Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
               QE +L  + N    LL+G+ L K      +   +   L+ +   +++++  S    +
Sbjct: 3746 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804

Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
               Q++ L ++L+       TWLD VE  L  +    L  EE        + L K+ K  
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3864

Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
               +D + N  S A  E        G  + V ED       R  L+   + Q+  ++   
Sbjct: 3865 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3918

Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
            + +                          +  F+Q    ++  I + E  L       +E
Sbjct: 3919 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3952

Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
              +   +LQV++    E+ + +D+ D+L+       +  ++    ++K + ++ L++   
Sbjct: 3953 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 4012

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
            + +   E+            E  Q L+++  E ++ L     LTET  + IIS       
Sbjct: 4013 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 4053

Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
                +L A A             LEY  ET       QQE  RQL           L+ E
Sbjct: 4054 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 4081

Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
            ++  +             +N+  P+L + L  G+   I       ++  +Q+ E      
Sbjct: 4082 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 4123

Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
              + K    L+  +   T++  +   ++  L+   +RL    +Q  ++  E+E +++ ++
Sbjct: 4124 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4178

Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
                 S +++    L  ++   G +++       K +    ++ +L ++   W ++ T +
Sbjct: 4179 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4238

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               + KL  L + +L  +      MS I  +++      D     I    + +  +  + 
Sbjct: 4239 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4295

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
             + +I+  Q  +D V    + + S+ + +    DK    + +  +N +W  L     ++I
Sbjct: 4296 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4351

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
              LE  +++  +Y++ +Q +  W +    +L     IG D  +V+  +++ +  +     
Sbjct: 4352 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411

Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
            ++ E+E++      L++   E+     V   L EL   W +L+  +   +  L+  L   
Sbjct: 4412 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4471

Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
               + A D++ ++L      LS  + + G  +A+++++     LQ+D+   + +++    
Sbjct: 4472 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4531

Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
              N L++         L N L+ +N RW N+LE+  ++ Q     L+   + K +  +  
Sbjct: 4532 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4588

Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
               Q   D    LL +       + A +++   ++ C        T K     L + G+Q
Sbjct: 4589 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4644

Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  +   SA + I  D  +L +   ++E  L +++T L+  +     F  SL+    W+ 
Sbjct: 4645 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4704

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
            +AE+ L       S  L T+  +++E K    + +S    +  L++ G  L      +++
Sbjct: 4705 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4763

Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
              ++NL       W  +  +  ER   L     + + F E     ME+L ++E+ L   +
Sbjct: 4764 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4823

Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
            EI+ +   +  Q   H+ FQ  + ++  +  +    G+ L E+  + DD  + +  L+ L
Sbjct: 4824 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4883

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
             ++W  +  ++ +R+  ++  +    ++ +  + L  WL  V    ++    V   +   
Sbjct: 4884 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4942

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
              L D      K F ++ G    +V+A K+    L+       + ++ ++ E+  +W++ 
Sbjct: 4943 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4998

Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
                  ++ +L   L+  E+    +   LE L   ++ L     LPD  + L     + K
Sbjct: 4999 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 5058

Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
            E    +     +L + + + DT+ A    D I+ +   + +++ ++EE+       +Q++
Sbjct: 5059 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 5118

Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
               L       E  + L  WL   E+ ++     +I + IE++K      + + EE+   
Sbjct: 5119 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5178

Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
            Q +  ++ +  +R A       SH                         ++IE K  +VN
Sbjct: 5179 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5238

Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
                +WQ +  L   R +KL + L  +++L
Sbjct: 5239 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5268



 Score =  298 bits (763), Expect = 2e-79
 Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)

Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
            E+EK  K  E +  DL           S A  S     ++  L      + ++YS    Y
Sbjct: 1286 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1345

Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
                +  N  L++   A+ L++L    L  E A        ENL S ++ + +E      
Sbjct: 1346 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1405

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
             FH+  +EL    A  D + K   + DL+     +K   L  R Q +      ++  L+ 
Sbjct: 1406 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1465

Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
              +    + D     ++ I+ +  T++K+ E    +  +S     +L++ K LVS +   
Sbjct: 1466 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1522

Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
              K+   ++ A Q   T  D    T++ R+M    Q+   + R +    + I+++ +D  
Sbjct: 1523 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1582

Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
            T +   V   T+ I    D L     E+ S  E     + H     EL++  S +     
Sbjct: 1583 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1635

Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
            +TL   +    P   ++    +EI+  +++     + +     K   K+  +E  + E  
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695

Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
            V+T   S      E+ + L       D ++EE            + + +  +E KEK  G
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1743

Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
            +  +L          + +  + +  ++LK     Q+++++  Q  A         T   L
Sbjct: 1744 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1803

Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
                +KL+++   +    L + K K + + ++A+  +K L + +     +  E  AAV++
Sbjct: 1804 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1863

Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
              E   ++   L     + K +E     H+Q I Q      +     S + E +E+   +
Sbjct: 1864 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1922

Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
            L+     +V   GT   N   Q ++    H+ ++ + + +       + + EK     S 
Sbjct: 1923 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1979

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
               EK+ + + EL    E      + +++      ++++KF+A+  + +  L+Q++  L 
Sbjct: 1980 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 2039

Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
            + E G          LK Q S  + ++S    L+       + ++  +S  +     V +
Sbjct: 2040 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 2099

Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
                    R  + A+    +   +CN++    +  V +Y+ YE     L           
Sbjct: 2100 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 2148

Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
                   + +Q  +A  S+H  E +A   K  Q Q+    +      ++ + ++  + V 
Sbjct: 2149 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2196

Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
            +++  AE   D  G LLP  +     +    GR   L   V E             S ++
Sbjct: 2197 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2256

Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
            G         N E S     + P         ++++I   Q ++  +   +A  ++    
Sbjct: 2257 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2314

Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
               E  +P    S  AK+ DL   +    +   E    + E   + + +++  + + T +
Sbjct: 2315 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2374

Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
            E     L+E   PG+         Q    E L  +  + E+  SL +E+ S    +D A 
Sbjct: 2375 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2433

Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
             L   + L+   + M  TI+ K              Q+L + L   ++E  ++  + +  
Sbjct: 2434 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2493

Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
              A++L   L  TK   +       E   +    +   N++  +     A++  +V +  
Sbjct: 2494 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2551

Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
             +L G+    +  E  A K L  +K  + ++     D  L ++    E     S +    
Sbjct: 2552 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2611

Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
             +S  + +WL +   T T+ +Q+            ++Q K  E EL +  + ++ +  + 
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2671

Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
             E+L      E + D  E P         D   QEL         + E+SS         
Sbjct: 2672 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2725

Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
            E+  +++  +++L+ +VL            +++Q Q+L          Y +      G+ 
Sbjct: 2726 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2785

Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
               G+ P+  +  V   L  + Q ++ ++ Q         Q+I    +    + + S  L
Sbjct: 2786 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2844

Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
             D++ +L  + A+    T     NQ++      +   + +K +   +QA  E+     V 
Sbjct: 2845 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2900

Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
            E+ L   L R    +L S   V Q+     + LQ      +  + +        ++  +K
Sbjct: 2901 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2958

Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
                   P++ +++ ++      K+F   +       +K   E  ++             
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 3018

Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
             +L+ ++  +D     +  R + L ++L    +Y+  ++ L   ++  Q  +   +  + 
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078

Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
             ++ E  I +L    KE  Q      +L  T    +    + KE  T  +  L+ +   V
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3138

Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
             ++ H +   LE + + +    E  +E  RQL+  +  +    S+G    +   L    T
Sbjct: 3139 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3194

Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
            + Q  + SL   + ++       + L++  S     SD+  Q+  + +   + + ++ ++
Sbjct: 3195 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254

Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
               LET L+    +Q+   ++        D L+        V ++ E ++        F 
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3310

Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
            K+++A  +   +   T   +L  ++   D   ++ +L  +  Q   LL    A +E++  
Sbjct: 3311 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3370

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
              + +L   +  S++  +  L++   + +E      +  + I++ L  +K F+ +    +
Sbjct: 3371 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3427

Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
              KQ  V+++ Q ++Q +++   ++  +       L  +N  W+ L   V ++   L+  
Sbjct: 3428 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3482

Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
            L     +++ ++ L +W  +T+E    Q+    +   V+  +++ + L+ L+  ++  VE
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3542

Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
             I++ G  +    +      ++  L  L   W  L +        L+ +           
Sbjct: 3543 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3602

Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
            + +N +L      L     +      ++ Q+   + L+DD+    + L +  SI  Q LK
Sbjct: 3603 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3661

Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
                   + +  +  + +  W     EI E+  S   LLQ                  + 
Sbjct: 3662 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3718

Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
            +      S +  Q+  T  L K  +   +  +++    Q+ +  LL GL  +K    D +
Sbjct: 3719 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3778

Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
              + +  E +K +      +    A  ++   L L++ L +  + LC     ++  +L Y
Sbjct: 3779 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3837

Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
            ET                ++L+G++ S +      Q R +ELK +     ++   LD LN
Sbjct: 3838 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3872

Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
            E+   L    P   +E   K +   N  + L+S   T++  ++ + +L+ Q F +  +  
Sbjct: 3873 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3932

Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
            + ++ +TE+KL    +I         Q +  + F  E+   + I+  ++  G +++    
Sbjct: 3933 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3992

Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
             +++     KL  +   +  + +   +R   ++       ++ E  E+L  WL E   + 
Sbjct: 3993 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 4051

Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
               +  +P P  +  TL  + +   ++   + +   +I  +      LL    G      
Sbjct: 4052 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 4102

Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
             E   IQEK+ +A     +++E  KK A  L +         D ++++    +++ + L 
Sbjct: 4103 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161

Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
                 + AE  + KE  +   + + D+ +L  L +TL        A     D  I    +
Sbjct: 4162 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4220

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
             ++++ +   WE +   +  R  ++ + +     F   +  L   +   +  +    D  
Sbjct: 4221 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4280

Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
            I+  + K +++     +EEI   QE    +  +G  L  A  E     ++  + ++N  W
Sbjct: 4281 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4340

Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
              L      R+ KL+E + A  Q    + ++  W+     +LA   PI  D    E +++
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4397

Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
            ++ E ++ + +  +    +  + +  E+LL        +++  ++Q     L   W ++ 
Sbjct: 4398 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4454

Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
               + R+ K+E       +F         WL  +E   +     G      + EL K   
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4514

Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
             Q  V    + +E +NK    L   +  + A +L+  +   NQRW N+ ++     ++L 
Sbjct: 4515 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574

Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
              + Q + F    + +  WLT+ +  L   +        AK +QL    +  +    K E
Sbjct: 4575 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4633

Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
                ++ +G+Q++ +        I+++++ L+   + V                   E  
Sbjct: 4634 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4674

Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
            L++R+ +LE++  L+ + +H+   D +    Q    L+++    L            +D+
Sbjct: 4675 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4722

Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
            +  + D     + ++ S   + +   D+ G   K F  +  V L  +      S  E  +
Sbjct: 4723 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4781

Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
            ++L   G++LDD+R + +Q         E +  S+     EL+ +            +K 
Sbjct: 4782 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4841

Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
            + K LG   S  D+  R    LKE+       + L   +   + + D+W+ +  +++ ++
Sbjct: 4842 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4898

Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
             ++++ L    QF   L ++  WL   E +L + Q +    DI  +   I   K  QK +
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4956

Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
              R + + ++   + E  +    +S  ++ ++ +++ RW+ VC+L    +  L+ AL Q 
Sbjct: 4957 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 5016

Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
            + FH + H LL  L   ++  R + ++P D +     L D HK+ M+   +L E +  + 
Sbjct: 5017 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 5072

Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
                M   +L           K  + +I  R + +L    +H + L   L    ++Q+L
Sbjct: 5073 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 5131



 Score =  290 bits (741), Expect = 6e-77
 Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)

Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
            S L S+ S LE  K   +  E      E+ +KEA  SEI +    K    ++   ++ Q 
Sbjct: 807  SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 862

Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
             KL +T     + ++ +     +F S      +W+ EKE+E  A + S    +  I++ K
Sbjct: 863  AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 916

Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
                  ++E++ K  +I  ++E A+   Q +     AR  I+A    ++     + +  Q
Sbjct: 917  DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 973

Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
            C+E     H+ +   + E     +++     + K A+  K  C  ++  +K+   +QE M
Sbjct: 974  CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 1029

Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
            +  + L    S I      A+ ++     N D  ++ +  ++     +Q E  + +  E 
Sbjct: 1030 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 1089

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
              A  +  A W+ +    +  +           + E    A+R+  E + Q +  L +E 
Sbjct: 1090 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 1147

Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
                  VVS     +++ +++ S  +VAS   +K M     +  L  L  R+ D  +   
Sbjct: 1148 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1199

Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
               +  +S V       +L    +V  K +  EL  ++E    +  V    +  + +EV 
Sbjct: 1200 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1251

Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
            + +  L++ +  L + + +    +DLH    +  +  +L +E  ++ +      +   EF
Sbjct: 1252 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1311

Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
                A+ S +      L  + Q +    SM+    D + K +N  L+N +A E A V L 
Sbjct: 1312 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1368

Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
                   Y  K+   E           +  +   I+NL+ T +   SE D    +  A +
Sbjct: 1369 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1411

Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
            D+ ++  K+I D   +T KER       KE   Q +++   V  Q+++ L         L
Sbjct: 1412 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1463

Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
            +   K +      + P +D  I ++E T    +R I ENQ +    +      Q +    
Sbjct: 1464 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1518

Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
             +   SK+ E          T+KD E     +     ++ K   K++ +    S    ++
Sbjct: 1519 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1575

Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
             E   + +   +LV T M   +    D  ++LEE    L        + +    E++ W 
Sbjct: 1576 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1631

Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
            +N              P   + IS+ +   + E+L +  ++     A   +++  +  N+
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1691

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
            L++  K L+   +L F E+  +++L+ ++   +V K   K    +  + ++ +  I    
Sbjct: 1692 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1748

Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
            T+ E  L+   +     +    LKK +  Q+ELQ      +     +      +     E
Sbjct: 1749 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1808

Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
             L +    LI  K +EA     QL  K + S +E L+K  + +++E  E     K   + 
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1867

Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
                           + S+R G    +V+E      Q                N+L++  
Sbjct: 1868 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1927

Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
            DGQ                       S+  AV   TQ  Q L      +LS +    +Q+
Sbjct: 1928 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1987

Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
             + +    ++  L +  K  +       EL  F+  + +   W+ + E+    ENL    
Sbjct: 1988 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 2045

Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
              I     ++ + + F         S D +S +G L  ++  G+   +  + CS+     
Sbjct: 2046 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096

Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
             +     +E  R    A     +L      +   +K + D+    E      L      E
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156

Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
               S+     +      ++  +   K  Q   SS +     ++   E L +    ++ + 
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2216

Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
               Q TL+ ++ ++ D  +  N+     E +   +   L  Q GL E    + +++S L 
Sbjct: 2217 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2273

Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
            E      ++ AL  +I+K+  L                    + +T D S   + Q ++K
Sbjct: 2274 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2333

Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
                +F++     KE + K+EE+     ++ +   +   +L +  + L        D + 
Sbjct: 2334 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2393

Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
             +Q       E ++ ++     L  + SL  E+  +   S   L+  +   L   +K+ E
Sbjct: 2394 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2449

Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
            D++ + +    SC E L                   ++ + +  F  +   L ++LE   
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2507

Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             L + W+ +                L+    T  + +     G  +L+  +     TE+ 
Sbjct: 2508 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2566

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
             +    L    +D++  S     L      L L+      N +    Q+ ++      QW
Sbjct: 2567 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2620

Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
            L  +N   T  +    P +   V T +++ + F +E +   +K+  +  K  ELL     
Sbjct: 2621 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2680

Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
              +A   +  +T     W+  +     ++  LE     +  F+     ++ WL + E MV
Sbjct: 2681 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2740

Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
                    D      ++Q++Q +L+E    +PQ  +L    Q +        S R     
Sbjct: 2741 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2800

Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
            +++ ++ ++ +L+    ++   +D+ + +  Q+   ++ L D ++D  + L S    ++ 
Sbjct: 2801 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2860

Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
               ++ +    + +    Q+++ Q+K+     E +      E +   + +QL+ +   + 
Sbjct: 2861 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920

Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
             +          L+ A +    +Q   R F  W+D+ +   N+S    A+L    +++  
Sbjct: 2921 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2980

Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
             K  ++ + + S + E    +G  +      +E    QL+L  ++  +    ++ KE   
Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 3040

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
            K ++ +    +Y+  ++    W+ + Q  L++       A   E ++  L+ LQ    + 
Sbjct: 3041 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 3099

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
              ++  + +T   ++   + + +   +    +SL Q       +L   +    N+  K +
Sbjct: 3100 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3157

Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
              ++  ++    L+ A+E++    S  ++  SN+    +Q  Q     + + A + +V+ 
Sbjct: 3158 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3212

Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
                AQ+++ E   S   S +  Q   +   +  L  QV E+  FLE ++Q +   ++++
Sbjct: 3213 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3272

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
                  +        ++A      +T+   K+ +T++  LK +E     L ++ +   + 
Sbjct: 3273 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3326

Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
             K +   E        +++++    +Q  +L    +     +E  +   +EF  K K  +
Sbjct: 3327 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3386

Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
              + + +E         ME      QL+ +K  Q+  +   +   + V   G+ L++   
Sbjct: 3387 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3446

Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
              T    L+  +D + + ++ L     +    L+  +     +   L+ +  W++     
Sbjct: 3447 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3505

Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
            LVA     ++  + +  Q+   K +   +   +  +  ++ +G+ +    A   +   K 
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3561

Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
             +   L      + A+ + A+   + LE          +TL+    WL+ ++  L     
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621

Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
                 ++  +Q+   +AL++                       +R   D++ S  D S  
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3681

Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
                  +      + ++Q L  A+   +   E+ +  +E+   L      D   + + ++
Sbjct: 3682 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3741

Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
             SEL        V Q    ++K    QA +N + E + + T  E      ++  +  ++ 
Sbjct: 3742 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3793

Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
            D+ + S ++    E+ LQ  R  H      C  + +V +E  + E   L   +A    + 
Sbjct: 3794 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3853

Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
             + LKK A   +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +
Sbjct: 3854 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910

Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
            K++ +    L      Q+   EL  W  E +  +          D     L        E
Sbjct: 3911 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3969

Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
            +   + ++  L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S
Sbjct: 3970 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 4029

Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
               QF     +    + + +  I       L  + + +Q +  +  +  +  ++  +  +
Sbjct: 4030 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 4089

Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
               G +L+ E++  E   +  K     ++Y  + +    R   L++ +     F +  D+
Sbjct: 4090 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4148

Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
                L++         ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++   
Sbjct: 4149 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4208

Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
               D       + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ 
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4267

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
            + +  F+R  + P  +        Q+    I +E+ GL E +D  +N   E   + G+P 
Sbjct: 4268 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4325

Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
            +P     +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + +
Sbjct: 4326 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4385

Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
            +      ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +
Sbjct: 4386 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4439

Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
            Q    ELKL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    + 
Sbjct: 4440 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499

Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
             + + I+ E+ K  + Q +V +    + A++    +    +    +++L++ L  L++  
Sbjct: 4500 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4559

Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
             ++ E    R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L
Sbjct: 4560 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4618

Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              HME    F + E+ + S +++   ++A        + + +++Q + +L+ + + +   
Sbjct: 4619 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4674

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
               +   L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EH
Sbjct: 4675 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4730

Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
            K   + VNS  E+I+ L++  + L+          +   + +V  RW ++     ++ + 
Sbjct: 4731 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4790

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            L+DA      F+    K  E +++ +  L           ++ T L  H  F   L  + 
Sbjct: 4791 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4850

Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
            S      +   S+          E+  L  +   + D    +++K  T  GK V+++ K 
Sbjct: 4851 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4901

Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
             E +         + ++  W+     Y   P +  D  +  ++ +++    NH+      
Sbjct: 4902 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4950

Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
                 +K LG  T      S+Q    AL    R+ I+    +    K   QELS + + +
Sbjct: 4951 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4998

Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
                 +  T+L+A                EE       L+E  A  ++ L  +G L    
Sbjct: 4999 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 5046

Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
               +  L + H++ +++ E + ++LN+A +  +      + + +  I  WI   +     
Sbjct: 5047 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 5106

Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
             +AW    Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E
Sbjct: 5107 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 5157

Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
             EE++ +I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 5158 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5214



 Score =  235 bits (599), Expect = 2e-60
 Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)

Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 769  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 824

Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 825  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 870

Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 871  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 925

Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 926  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 976

Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 977  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 1035

Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 1036 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 1095

Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 1096 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1154

Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 1155 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1208

Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 1209 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1261

Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 1262 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1320

Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 1321 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1375

Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 1376 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1431

Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 1432 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1491

Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 1492 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1549

Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 1550 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1595

Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 1596 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1636

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 1637 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1690

Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750

Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1810

Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 1811 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1865

Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 1866 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1925

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 1926 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1982

Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 1983 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 2042

Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 2043 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 2102

Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 2103 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2162

Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
              +      +  D    +  L + + LQ   +  Q  +  +  T E   D   S +P   
Sbjct: 2163 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2217

Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
            D  + L+ +   ++     ++E   +    + +   ++    ++ +W+   E  +  + +
Sbjct: 2218 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277

Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
               N    +  + +     +++   +  +  +  + ++ ++ +  ++    QA    L++
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337

Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
            R+        + L +++ L+ +++  E     L ++ +               + ++   
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397

Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
            M     + LE   K +E  HSLLK     G  + K L   +   L K       + KE+ 
Sbjct: 2398 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2449

Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
             T++++   +         F    K+L  WI E  + + +  +P     +    L   K 
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2508

Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
            LQ+      P ++ V   G +L  L+  VT                              
Sbjct: 2509 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2568

Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
                  +K  +  +   Y+DL  + K+ +  L  K+   +    E   + +WL +M+   
Sbjct: 2569 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2628

Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
                  P   +T +++T  +Q                                      K
Sbjct: 2629 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2688

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
             M+ EI      LN L +     + + +++L      +A+LKQ      +   + G    
Sbjct: 2689 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2748

Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
               + +T ++  Q L   LQ+  +R+   +Q  A   A Q  L    + P  R    +Q+
Sbjct: 2749 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2802

Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
                A+ ++  +    L   CD +  A VK+T    Q   +++  KL    N       +
Sbjct: 2803 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2857

Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
                  +   L+ A +  Q +++   +++  +AQ +   +   VK+ +  +A ++  +E 
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2914

Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
            + K  K  E      + HL                   WLD  ++  N            
Sbjct: 2915 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2974

Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
               ++  +D  +T      M                      +++ L    T WD   + 
Sbjct: 2975 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 3034

Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
              E      E+L+K                            L   E + +I  LK  ++
Sbjct: 3035 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 3094

Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
            +M +H  + +             E+ KE  +   +   Q  D++  ++      LE +  
Sbjct: 3095 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 3153

Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
               +F+E  E ++E +  +  A +Q    D   +Q     +L +    +     LK  + 
Sbjct: 3154 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3211

Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
             A R+  DL      V++ + S   S V    + + Q    L++ + EK  FL    Q  
Sbjct: 3212 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3265

Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
               Q   R++   F E    L     V +  +T +  + ++K +  ++  L A      K
Sbjct: 3266 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3325

Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
                   TE+   +++G    L+ L    + +L +   R +++E  +   + F     + 
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3385

Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
               L++A+     +  +  E+  ++ QL  ++  + Q  E E L    Q     GQ ++ 
Sbjct: 3386 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3443

Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
            S         L   L+ +  ++  +      +  ++QEA+L    +   +E     + + 
Sbjct: 3444 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3503

Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
            E           +  V +A +  Q   + +LD+       V+ + ++ E   +T +P   
Sbjct: 3504 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3560

Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
             K+L  ++L    +  L  + E R   LE  +   Q+  +  + L   L ++  E+  VN
Sbjct: 3561 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3618

Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
             E +  +  KL+   +   +L+D  I   +       +   L  L+  + +  +QS    
Sbjct: 3619 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3678

Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
               W  E++  + +  E + +  C +++     F  +    ++WL  V  +LS     D 
Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3733

Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
            + + + ++  ++++ QE++   LR  N     L+  E  K T   E++   ++  L  + 
Sbjct: 3734 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3789

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
                DI +       TL +     +R +   +    WL+  + ELL      L  E A +
Sbjct: 3790 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3849

Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
                  E         + L+ L+ + + L  L+    +E LE+ VA    R + +S    
Sbjct: 3850 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3909

Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
             +V+ +     +   + +A +  +  + +TEKKL     ++     +   +L   K    
Sbjct: 3910 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3968

Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
             +    + I  L +   ++    ++  K ++ + +  V + +  +  +  ++   LE A 
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 4028

Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
                 F    ++    + + Q  +    A       L    E H      + + +  +  
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 4088

Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
            + +    +L+     +PGE   + ++  A       ++E VK     + + +        
Sbjct: 4089 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4144

Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
            +I+ +   ++   E L  P   I A++E+++  ++E  N   ++EK+       +++ E+
Sbjct: 4145 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4203

Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
             +        ++S +  +  LD  + I + I   ++E E       EL+   +K   D  
Sbjct: 4204 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4260

Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
            +++  +K   D              V Q +   + + EE+DG   +L  +     + +  
Sbjct: 4261 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4320

Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
             G+  KP+ KK I +L        +  ++R+ KL +A     +Y + L+ +  W++    
Sbjct: 4321 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4376

Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
            +A G +A  S S +       +  +EE K+  S  EA  ++++        E+++ Q   
Sbjct: 4377 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4425

Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
            L ++  E     +     +QD   ++K      E  +   Q  LE A   L   +     
Sbjct: 4426 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4480

Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
            L   L+H + LLSE + +   PK   ++L +  + +  DV+A      A  +        
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4539

Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
               EEAS LQ+         Q  + + EQ +Q++    +  +G H EIED          
Sbjct: 4540 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599

Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
                 KP+     +  + Q++ H E+    +  +E   SL  K + +  +   +      
Sbjct: 4600 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4658

Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
             ++  L E  E ++ +L    +     + +     ++L   +   +  E T +  S    
Sbjct: 4659 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4714

Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
               PS + +T    +++   +   +++ R Q    ++  + +  + F +          L
Sbjct: 4715 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4770

Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
              +Q  WE +   + E+ R+L +A +R +++ ++   +   +E  E  L    E    P+
Sbjct: 4771 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4830

Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
               +Q+A+H+    + L  +  + +  +     L  ++  AD  + L L   L+ L ++ 
Sbjct: 4831 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4887

Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
             TI  K+  ++  LEE L   L   +   ALQ        L  WL   +  L     P  
Sbjct: 4888 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4936

Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
              +D+   L+D      +   K  +  +    +   L+EG   ++D++  +  +++ L  
Sbjct: 4937 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4993

Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
                +      KQ  ++   ++ EE    + A     + EWLA+A  T            
Sbjct: 4994 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 5048

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
              ++ + Q KE  ++L E+++ L    + G+ +L
Sbjct: 5049 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 5082



 Score =  224 bits (570), Expect = 4e-57
 Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)

Query: 500  LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
            L+K +  EL  +L  L    E  S +  W+ K  +  +  Q        +   + +E +K
Sbjct: 2592 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2651

Query: 552  FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
             FE    Q     Q LK      ++ +    EA    + + E  ++W+ L+      +  
Sbjct: 2652 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2711

Query: 608  LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
            LEE  +N  ++    A L+ WL + E              MLN      +   +      
Sbjct: 2712 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2771

Query: 655  QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
             Q+  +  AG  ++     D  +   +K+QL  +  +W  L  ++       D+      
Sbjct: 2772 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2831

Query: 712  EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
            +Y   + +LS   ++   KLS  L VS     MN +L     + Q+++  ++++ V  A 
Sbjct: 2832 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2891

Query: 762  --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
                  + K  +L  + S Q EG  K       K +  +  ++  C S   ++  S+   
Sbjct: 2892 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2951

Query: 815  IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
              L+  +++    +    K++ + +++ + +  S  L  Q H  ++ +A  EN    L L
Sbjct: 2952 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 3007

Query: 872  IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
              +GS+     + L+ +  ++D     +Q+ +     +  ++K   +K+ VET    + K
Sbjct: 3008 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 3065

Query: 932  FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
             + +  E++  L  A EG       + L +   + F  ++      N+ L  C+   +++
Sbjct: 3066 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 3124

Query: 990  PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
             ++ +  +Q+      +LH +   L+          ++  E  R L   +E   +LD   
Sbjct: 3125 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3181

Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
             L  Q  S K +    +  + +      + ++ L + L   L V     D+ GT  V L+
Sbjct: 3182 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3236

Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
             E  A   ST  + +++   + +   +    F + I    +Q      E    A  G   
Sbjct: 3237 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3296

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
              ++       K+ ET+     +L+ L  ++S + A K    +     +   LV +  ++
Sbjct: 3297 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3347

Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
            E   K  +   D  Q +E      +K  LEE  S  KE            + Q    ++T
Sbjct: 3348 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3406

Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
            E + +   +  +  +++ + +  K++DV    Q + Q+           H +L  + +  
Sbjct: 3407 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3465

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
              L +   ++  ++Q  L    RF+   E+++ ++  T    ++++  S +  + + +++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3524

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
            ++ K   +  +      E + +E  +I     P +K  + +Q   +  + + L +  E  
Sbjct: 3525 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3584

Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
             + +E +      F    E L+ W+T  EK L     + T +S ++ QI+Q K    +I 
Sbjct: 3585 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3644

Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
            +    +       QS     +  +   +++KL   + +  E++E +      +   L   
Sbjct: 3645 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3704

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
            + F E+  ++   ++E  DKL+  + +   +TE         +VLQE  D+    +++  
Sbjct: 3705 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3761

Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
            A+       ++    +  +   +  A++ +Y+DI + + +    LE  L   +RL     
Sbjct: 3762 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3821

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
               TWL++ E +  S E  +       + +++  + L+ E  +  +    L ++  +L  
Sbjct: 3822 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3880

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
            +      + ++  + + +ER+R +   I +++  + + +   QQFD+   +   WI    
Sbjct: 3881 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3940

Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
             +L +  +I +   Q +  L   K    E+   K  +  L     K+ +    E+   ++
Sbjct: 3941 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 4000

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
             K +   + ++   Q+   R L L    S + +F +++  L   L +  Q++ +      
Sbjct: 4001 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 4059

Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
             E + + +   +  Q  + +      +D +       L++   E          AD L  
Sbjct: 4060 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 4119

Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
            +++           EA + +     F D+ +++L+S+E I ER  +        + ++++
Sbjct: 4120 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4176

Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
            +     +  ++   +     LK + +++        KD++ A  V  +++++   W++  
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4235

Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
             L+ E + +   +++L  ++           ++ S ++  + T   I+D ED       +
Sbjct: 4236 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4286

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
            K      ET + +++  Q++LD   + G  L++      K I       + +  +S    
Sbjct: 4287 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4346

Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
            W D  +KLEE M   + ++   D + +  D ++  +   +  M+   ++L+   +  E L
Sbjct: 4347 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4402

Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
            K+F+SE   + + +E L+   +  + L K +    D   ++  LM+ KL  +  +E    
Sbjct: 4403 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459

Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
             +  L+       Q +  ++++  W T  E  L          +  E  L K   +Q ++
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519

Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
             + QS + +  +  N L       E  +L   +  L ++ + V +   + +  L  +L  
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579

Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
             K F   +++ Q+W    +     S    G  +  + +L+    +  +    +    ++ 
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4639

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            Q+GQ + A   K   ++I + I    E++++   +  + K  L++  +    F +  +  
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4699

Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
              W+ + E+  N  +           + + HKV  F  E+ + RE + +L + G  L  +
Sbjct: 4700 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4755

Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
                 Q+  L   LL S Q+    +++   E+ RS   A +  +   EA   +  W++  
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4815

Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
            +  L          D ++ +L+Q ++     G      +     G     ++S  +    
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875

Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
            +   L  L++ W  I   SV  Q+ LE  +     + +    L  W+  V+ ++      
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935

Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
               +     L+D+ ++   E    T ++  L   +REL E   +D S+     +EL T++
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4995

Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
              +  ++  K  ++E  ++    +   VH   +WL  A++ L     +  D  A +  + 
Sbjct: 4996 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 5055

Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
            + KE +   E   + L++  ++   V           +   +  +RA   ++E+ +   +
Sbjct: 5056 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 5112

Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
               + L S +A       G +A+ ++ LE   A L+ WA+  T L  K  D+E++     
Sbjct: 5113 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5155

Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
             QEI           E++K+ + E   F  +++     V  + K Y
Sbjct: 5156 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5189



 Score =  210 bits (535), Expect = 4e-53
 Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)

Query: 20  RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
           R+ DE++ VQK+TFTKWIN HL K +    V+DL+ED++DG  L++LLEVLSG  LP E+
Sbjct: 206 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 263

Query: 80  GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
           GR   R H + N+  AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++ 
Sbjct: 264 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 321

Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
                              V+ E+               +AK+ LL W Q       GI 
Sbjct: 322 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 350

Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
            ++F   WR G  F+++IH  RP+L+D+ TV  +SN  NLE AF +AE ++G+ RLLDPE
Sbjct: 351 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 409

Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
           DVDV  PDEKS++TYV+     +P +     +G   +++   +  + N V    +  R  
Sbjct: 410 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 468

Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
              M       ER      +    L ++Y  FK   +      + K K++  L++     
Sbjct: 469 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 522

Query: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
           G++ L Q       ++      +W            G +   +   E ALR E+   ++ 
Sbjct: 523 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 564

Query: 436 EETANTIQR 444
           ++ AN +QR
Sbjct: 565 QQIANRVQR 573



 Score =  162 bits (411), Expect = 1e-38
 Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)

Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 1187 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1244

Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 1245 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1304

Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 1305 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1349

Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1400

Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 1401 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1460

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 1461 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1520

Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 1521 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1580

Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 1581 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1640

Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 1641 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1700

Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 1701 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1760

Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 1761 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1814

Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 1815 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1874

Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
              W+   ++  +     H                                      + T 
Sbjct: 1875 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1934

Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1994

Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 1995 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 2054

Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 2055 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 2114

Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2173

Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 2174 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2230

Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 2231 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2290

Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 2291 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2350

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 2351 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2405

Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 2406 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2464

Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 2465 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2522

Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 2523 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2582

Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 2583 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2642

Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702

Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2762

Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 2763 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2822

Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 2823 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2878

Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
                    V     E     DLS  ++    +A  S   EG  +  KD   +    +   
Sbjct: 2879 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2933

Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
             SA  S  Q +Q+ +   A  D++ + Q   + I +K      L   +K + K L   S 
Sbjct: 2934 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2993

Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
              + ++   E+ L + + S    + L     +T      W+    Q   +E ++K++L+K
Sbjct: 2994 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 3048

Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
              ++   + ++W W+   +  LE+   ++   D    E  I KLK LQK +D    ++  
Sbjct: 3049 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 3105

Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
            +N  +         +   + D    +  + D V   L   +  L++   + + F E+S  
Sbjct: 3106 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3165

Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
                L    E +D   +      SN    +LQ   K L  +KH++    L     QD+  
Sbjct: 3166 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3222

Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
            +   +++GT   +   +V  I      L ++V      LE KL  +   Q  +    S  
Sbjct: 3223 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3279

Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
                DELD+   V    GR     QK
Sbjct: 3280 AEFDDELDSMAPV----GRDAETLQK 3301



 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)

Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
            DL++W   +Q   DR E W     +V   LE  ++   A  EF      +SSLK + +S 
Sbjct: 788  DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 840

Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
                  LK     T   +L R++SQ+  LL N    QE+ H   +    SR A +E++ W
Sbjct: 841  IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 892

Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
            ++      +K+E+ +  +  +   +  + + K +  ++  +    +   +SV +I+ Q +
Sbjct: 893  LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 944

Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
                  +        AM   W  ILQ     +  + E    ++ E+ N+ +    +    
Sbjct: 945  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 1002

Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
            +  +++++     +S+         LEDL++   +E E++ Q  + +A +  K + +  +
Sbjct: 1003 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 1055

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
                     +T   +  +    +I +    D       +SH+  +  I+    EA     
Sbjct: 1056 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 1115

Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
             F +   + EAV +      Q  N+  L  +     +S+  +  + N++ +     V   
Sbjct: 1116 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 1175

Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
             T         L  +  R+ + LE+  E Q+ S   + QL        Q Y++  K    
Sbjct: 1176 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1235

Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
              Q++                    EDR    ++    +D   + V   I +   L K L
Sbjct: 1236 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1294

Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
              +KD L  +    E+   Q  A+A+S++ + +  L+  L  + Q      T +   +  
Sbjct: 1295 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1351

Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
                 K+ +A EA +      +  EE +     +  + +ST+++   E+  +   F ++ 
Sbjct: 1352 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1411

Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
             +L +   +   +    KE         ++   L   W  +  Q   R   L+     L 
Sbjct: 1412 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1471

Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
             ++      + W++ +  T++K+      N + L  Q    ++  +E+  +Q    S + 
Sbjct: 1472 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1527

Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
            + Q+  EQ     +D     +T                R ++DSQ +   + R M     
Sbjct: 1528 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1572

Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
              + E   L       V +  Q  +   D ++  E+                        
Sbjct: 1573 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1608

Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
               E +L+ E  E  EK K     L++    ++  LKD EK  K        S E++ T 
Sbjct: 1609 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1662

Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
            K++LS++L      L  H ++M  +E             Q+  L+++ +   S       
Sbjct: 1663 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1710

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
                 L Q Q  +    + +  + + ER  E   + EK + +C+ LTQ E+++  +    
Sbjct: 1711 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1762

Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
              GD  +E        E+L+KD Q        + +  +  L++ GE+L+   KA  E K 
Sbjct: 1763 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1822

Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
            +E + K  ++N + +     L  ++   +K+  E + AV+QL+++   + +L  WL++++
Sbjct: 1823 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1882

Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
              SE A    K ++             S   EE                   Q  LN+Q 
Sbjct: 1883 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1942

Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
            +      ++ I +H   + +  +  +VLL       +  E + +Q+  + L   +    A
Sbjct: 1943 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 2001

Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
             S E+++K+  + +   +KF  DY+ FE WL+ SE+      +          +LK+ ++
Sbjct: 2002 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 2060

Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
            F   V      L  I     R+             + D++ +   +++ +     R+ +L
Sbjct: 2061 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 2120

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
              +   +   LK  + + + +E A   +L  L     + T  +H SE       ++Q ++
Sbjct: 2121 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2178

Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
            ++ KA Q +IS     +E++    E L++    L  A   I++ LD++    +++   V 
Sbjct: 2179 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2238

Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
              ++KL ++ L         R L ++D      L W      SL      P  S+ L   
Sbjct: 2239 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2288

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
            +++ +  E+      +S+++          ++  ++  M    PS     Q   KD   R
Sbjct: 2289 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2338

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             +   S  H    +++ +L   ++      ++ +  + +KT    E+D   K   +L   
Sbjct: 2339 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2397

Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
               S      LEHK   E   SL   ++ H   +  A V+++   L  +    E  +K+ 
Sbjct: 2398 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2455

Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
                    ++   F   + S+ +W+ +T ++                LE  ++L+    +
Sbjct: 2456 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2515

Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
            +T E+Q        L  L  AV      I ++     + + E T  +++E         +
Sbjct: 2516 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2575

Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
            +  ++ ++  ++ +  LL++    L   L + Q   E S  ++  L+ +++   +     
Sbjct: 2576 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2635

Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
            +  D E ++   +Q    + EL ++  +V  L+D   +LL   E  D  EA         
Sbjct: 2636 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2685

Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
            R K +L E+    +EL +L       L+ SS+        +  L  W    EL  S  + 
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2744

Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
            P S    PN   T R +  +     +   P            LS PG   S RG +   L
Sbjct: 2745 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2802

Query: 8746 RA 8747
             A
Sbjct: 2803 AA 2804



 Score = 54.7 bits (130), Expect = 4e-06
 Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)

Query: 366  EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
            E ++Q L   G+ SLD A  + + +    S+L +W  + +KSL + L          E+A
Sbjct: 4778 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4826

Query: 425  LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
                           + I+ +L QHK+  ++  A     H +Y T +  G  +       
Sbjct: 4827 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4870

Query: 479  ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
                   D L ++ +++  +   S        E  L   +F +    L+  L   E +L 
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930

Query: 525  SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
                 +G  + V  L+ N+ +F    K   +   + Q LK++A   +  +GS +++  V 
Sbjct: 4931 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4985

Query: 585  KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
              M E + +W  +     S ++ LE  +   + + + V +L  WL +AE+      +L  
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045

Query: 639  SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
             E+A        K+F + L     +       G+ ++  C       +K  + ++  R+ 
Sbjct: 5046 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105

Query: 692  ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
            E+    KQ+ Q  A  +  +  K+E  + ++    +A T    K  E +      VK LI
Sbjct: 5106 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5165

Query: 747  QD----LEDIEQRVPVMDAQYKIITKT 769
             +    +E++ ++ P +D     +TKT
Sbjct: 5166 AEHQTFMEEMTRKQPDVDK----VTKT 5188



 Score = 33.9 bits (76), Expect = 7.3
 Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
            Q +QL+++      A + +E+  LR  C  V+ +      +  +L +      L+    +
Sbjct: 636  QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 690

Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
                +  S L        SL     SS+++  L+  + S  +   TPA     P      
Sbjct: 691  TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 739

Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
              L  +  S +      E    Q  K   +R  +  S   D +  E +I     + L   
Sbjct: 740  -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 792

Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
            +D+ + Q+ +TE    S  P+      ++K   + + E  SS+      E K+ E + + 
Sbjct: 793  VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 845

Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
            P        +   A  + R E   A+ L+     +++L     F S   +   WL + EE
Sbjct: 846  P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898

Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
            E       E++ D       I + K    EL + +D ++  I S+   + +    +    
Sbjct: 899  E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 951

Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
              ++   + M  +W  +  L +     +++     + F++       L  L++  +RK  
Sbjct: 952  LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 1009

Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
                D +     L+D  ++ M+ K ELL+ +  +A+L   +  ++ +    +DC
Sbjct: 1010 -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 1062



 Score = 33.5 bits (75), Expect = 9.6
 Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)

Query: 375  DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
            D  L LD  L  ++  WD +  +  +   +L+++L         L  +  WLYR E  L 
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930

Query: 427  EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
            E+  V    +   N I       K+L + T    A KR+  E+      +   V   Q++
Sbjct: 4931 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4989

Query: 484  DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
            +++ R+  V + S     ++        EF  + + LL  L  AE  L+   +     ++
Sbjct: 4990 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049

Query: 536  VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
            +  L+  +  F                +K+  E   + + +    + V+   +     T 
Sbjct: 5050 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093

Query: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
              W      +  +R+  EEV++   ++   +AS  A L            AK++    L 
Sbjct: 5094 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 5136

Query: 652  HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
             W+Q       A   L +   E++ +++++   L+     + FME     Q D +D++ K
Sbjct: 5137 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5187

Query: 712  EY 713
             Y
Sbjct: 5188 TY 5189


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  372 bits (955), Expect = e-102
 Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)

Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1341

Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400

Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
                T    +V    +Y+   G S +R       +SL  E ++  E +K  +        
Sbjct: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1458

Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
             +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D   +
Sbjct: 1459 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512

Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
              E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L  +
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
             ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K   
Sbjct: 1573 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1629

Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
                 EDK  +  K+  +     K  Q ++   Q+ + L   +T                
Sbjct: 1630 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1671

Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
                A++++ E +  +++ +E +T +ENLL     ++K+           +    T  + 
Sbjct: 1672 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1727

Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
            G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+  
Sbjct: 1728 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1787

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
            +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD  
Sbjct: 1788 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1845

Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
               F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+   
Sbjct: 1846 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1905

Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
                        K+ +     ++      A D F+       V+      L  L +  Q 
Sbjct: 1906 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1962

Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
            +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ + 
Sbjct: 1963 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2021

Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
              A+  L    S    +   + T D + G  E +   +  +  +         + QD  +
Sbjct: 2022 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2081

Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  + 
Sbjct: 2082 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2141

Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
             D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  + 
Sbjct: 2142 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2201

Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
             + T   +  KD  +L               Y Q+    F    KHL    S LK+I S 
Sbjct: 2202 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2247

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
                + +D    ++K  ++S+K +E  D ++      + V S +++++ +        + 
Sbjct: 2248 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2301

Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
            + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   + 
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2360

Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
            TP                AK I  V  G  + +    +T  E+F  +     T +++ + 
Sbjct: 2361 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2402

Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
            + +       L  +KD   EL ++ S +   QE  +++ +        +     T     
Sbjct: 2403 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2461

Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
             EAV     KTQ    +S E    +++ + QE                     L+ KL +
Sbjct: 2462 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2495

Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
            L                + +   T  A   KQ+       +T+ + ++Q   +  +  +Q
Sbjct: 2496 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2532

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
             L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E  
Sbjct: 2533 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2590

Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
              +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A+ 
Sbjct: 2591 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2650

Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
            +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K+ 
Sbjct: 2651 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2710

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
             A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +  
Sbjct: 2711 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769

Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
               + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        + 
Sbjct: 2770 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2820

Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
            IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + V 
Sbjct: 2821 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2879

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
                W+                    Q  L +IK  +D  E G + +++++SL  E+ Q+
Sbjct: 2880 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2921

Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
                  EL++    +L +  +  ++ V      L   V  +          +  + Q  +
Sbjct: 2922 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2979

Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
            +F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R +
Sbjct: 2980 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3039

Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
            +DL   +    G          + +E++ L  Q  + C   E  LQ         +    
Sbjct: 3040 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3099

Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
             F +F   L +          + +    +   L+K++  ++ ++N      MML+  E  
Sbjct: 3100 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3159

Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
              L+      GI+  + A  +           +E  +E    ++++F    +     L K
Sbjct: 3160 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3213

Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
             E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    +A
Sbjct: 3214 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3267

Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
            +KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D   
Sbjct: 3268 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3327

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
            ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I +
Sbjct: 3328 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3387

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
            QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E    +
Sbjct: 3388 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3447

Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
                   + + K L +++++++  L      G  +       +  + Q +L   Q  Y  
Sbjct: 3448 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3507

Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
            IQE++       ++ +   + +  D      WL +  +KL + SV +         ++ L
Sbjct: 3508 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3567

Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
            R LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++  
Sbjct: 3568 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3625

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
                  +   R +    +++  WL   E E +S  T+        + Q+   ++KK  + 
Sbjct: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3685

Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
              A  D + EV +   E++      +R G +    +   RY+ +   + ++++ ++  I 
Sbjct: 3686 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3742

Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
              ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     +   
Sbjct: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3797

Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
            ++    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +F 
Sbjct: 3798 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3857

Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
            +  + L  W+ E Q I+     P +E    + Q  +++ L++ +  H+P +  + + G  
Sbjct: 3858 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917

Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
            LLEL   +  ++++K     + Y  +    K+   +L+  +     ++ ++ ++ + L +
Sbjct: 3918 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3977

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
            +  RL  P  + ++ +E I +Q++ +K +  ++   +     L+ +G+ +I +       
Sbjct: 3978 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4036

Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
              A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T++
Sbjct: 4037 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 4089

Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
              Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +  
Sbjct: 4090 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 4147

Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
               VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L +M
Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207

Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
                ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   + L
Sbjct: 4208 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4265

Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
             +    W  L  +  N   + E  L     +   ++ +  +L               +  
Sbjct: 4266 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4325

Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
            A+ +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  + 
Sbjct: 4326 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4385

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            +  +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H+ 
Sbjct: 4386 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4445

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
            +C+  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  L 
Sbjct: 4446 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4505

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
            +AL+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++ +
Sbjct: 4506 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4565

Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
            +  L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F E
Sbjct: 4566 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625

Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
             + K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+++
Sbjct: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685

Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     L 
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
             +E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R   
Sbjct: 4746 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4803

Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
              W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+  
Sbjct: 4804 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4860

Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
                LP +E      +  +      L++    L + T   + +     P +    +H I 
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4920

Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
              +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + + 
Sbjct: 4921 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 4975

Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
            I +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD     
Sbjct: 4976 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 5034

Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
              R   ++L    SQ Q             ++ QV+  A       ND L+  +EL + A
Sbjct: 5035 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 5094

Query: 5020 GNGLDV 5025
                D+
Sbjct: 5095 NFDFDI 5100



 Score =  340 bits (873), Expect = 3e-92
 Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)

Query: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 1112 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1169

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
            K++ + L   +L     AE+ +K +  K    E+V   +  ++N +S +        E  
Sbjct: 1170 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1226

Query: 551  KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
            + F   E        ++ ++ K   E  +  D   E+A+ +++       +W+N+ V++ 
Sbjct: 1227 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1279

Query: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
            +    LE +  +   Y +T   L  W++  E        NQ EN+K    + N    +  
Sbjct: 1280 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1339

Query: 657  HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
               M  +     +   E  S  +K   L       +++ + +     VK+       D +
Sbjct: 1340 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1396

Query: 710  KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
             +E+ D     +A  T     +++ ++ +  ++K L ++ + +E+       + K + K 
Sbjct: 1397 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1452

Query: 770  AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
               I+K  +  ++ GK  F+      E+++  KE  S  L   Q  L             
Sbjct: 1453 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512

Query: 819  ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
            ELEKQ+ +  +S   +        +E+Q+S   K + + +   Q+  K+ L         
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572

Query: 871  ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
                        +I  G+  ++K+ +    L+  D     + +A++    ++ +K+ G+ 
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1631

Query: 919  -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
                 K  +E           +L  K E+S+ EL+KV+  A +E  E+    ++L    T
Sbjct: 1632 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1691

Query: 965  EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
            +  + LD      +L   D+ ++    + +Q +++     H Q  D       + E   +
Sbjct: 1692 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1743

Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
            LL   +D +    + + +E   +  ++ K       EKII +H+ V  + +    L EK+
Sbjct: 1744 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1795

Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
             Q +  EE   K  ++  +++        L E    +  T+  L E+ +K+  DYT    
Sbjct: 1796 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1847

Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
            EF  W+  +E +L+ ++  A D      ++KR      + ++ +G+      S  +VL  
Sbjct: 1848 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1907

Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
              S         + +    +   KL  +     +L S+   + +N  D V   +  +++ 
Sbjct: 1908 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1967

Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
              L++G +  +  A K L +E +    + L    ++TK +  +    Q  + + ++    
Sbjct: 1968 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026

Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
            L D     L     ++ TLD        L +S   +  ++Q+TL +    +   + ++ +
Sbjct: 2027 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2086

Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
            +    SS +      L+ ++L+  +S  +   ++ + R  SI    E  VK+  E    P
Sbjct: 2087 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2144

Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
                 LQ + K +  +  +     +E +  ME +KTK + F +  E L  ++  K + L 
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204

Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
             ++     +      ++ +  E       +  L    +  +      + A +  K   + 
Sbjct: 2205 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2264

Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
            +  +E+ +  +  +  +     Q   F+  ++ ++  + E                    
Sbjct: 2265 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2324

Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
             ED   +  K      E  KV    + LC  + ++++   A +A  S   V+N +     
Sbjct: 2325 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2384

Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
                       S  ++   +   YED+    K++   L   L+  Q+ ++E S+ + WL+
Sbjct: 2385 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2444

Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
            +    A+  +      D  A + +VE        L+  V        KL +L E      
Sbjct: 2445 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2504

Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
                 K M   L ++D +W++L Q+   R   L+       QF  +      W+   +L 
Sbjct: 2505 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2561

Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
            +S L   S           ++ I+  + A TR   +         + S+ GE  SL+G +
Sbjct: 2562 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2619

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
             K       +    L G+  D     ++A     + Q  L  L+                
Sbjct: 2620 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2679

Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
                    + L++   +   ++Q ++ ++   ++ ++ S L++++   A + ++ LE   
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2738

Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
             S   +  KA+ H+     +   S  A++ Q        Q  L TK+ E +        L
Sbjct: 2739 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2793

Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
             VL+   +D K+  + L +   + E+T  E      + +   + ALQ +L       D  
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2853

Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
            N      E++L    +KA +  ++     P +D+  N LE      D  +        + 
Sbjct: 2854 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2913

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
            + +   Q  G+++L+    N   +V +     V +   S+I     + +Q        E+
Sbjct: 2914 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2973

Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
            +   F + +     +K ++   ++ LD   S G    S                     +
Sbjct: 2974 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3033

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
            L K  + D  +  +D + T D  L V E + +    L   +      L T+ +  G   N
Sbjct: 3034 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 3092

Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
             + +M    +  D+ L       R  E L++ +  +K    +LE L +  ++  +  K +
Sbjct: 3093 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 3152

Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
                ET PDL  I+ DL    +   ++ + A+       A+  QVE  I  +  +++K++
Sbjct: 3153 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 3205

Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
            E    L    ++E  +             L   K  QKE    LQ +Q +++   + L  
Sbjct: 3206 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 3265

Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
               K  S   + L   +  +  + + +++  ++  A LQE+L     F ++++    W +
Sbjct: 3266 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 3323

Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
              +         + + KV++A++ + + +   + D +S ++ + +EG+ +          
Sbjct: 3324 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383

Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
             I +Q++  +  ++A L +     + L+  +     F +    LN W+  +E+R  N E 
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443

Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
            +G     + E+       ++++      L + ++  +SL  LS R      E     Q  
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3497

Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
               SQ+   +  +   +  +    Q AL   +   E    +  W+  + D+L+       
Sbjct: 3498 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3555

Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
            S + L K+ S++    +DILL K      ++ A+  G + L+ +  +   +IQ +LE +K
Sbjct: 3556 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3611

Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
              + DI   S     TLE  +           +L  W++ V+ ++          E   Q
Sbjct: 3612 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3671

Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
             Q   KE      + +++L    + + AL  L+  ++RE  EK   E            +
Sbjct: 3672 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3722

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            +  +     +K+ +++  +     +  A      W+   +++L    D+  +   T  +L
Sbjct: 3723 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3782

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
               K    + EI   +         ++  +   SG ++M    +  +   K+  D V + 
Sbjct: 3783 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
               +  + S+  L  +     V Q  +  E+    L      ++ L     + E + +  
Sbjct: 3832 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3891

Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
             + +++ + + + +P  + +     +L   S       G+   + ++Y   + L  Q  +
Sbjct: 3892 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3945

Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
              + +   L +   ++   F   +     +  +  +  +    +S  ++KI+E +SE++N
Sbjct: 3946 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004

Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
                +  +    E L      ++ +         AK +Q K+      W+N H+ + ++E
Sbjct: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064

Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
            + L ++    + F      +   +  T+  + +  +   D    +++Q+  +++ EEI  
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 4124

Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
             + +L+ +     +L    G+      +  + +L+S + +L+   K+++ +L+  +    
Sbjct: 4125 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 4184

Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
            Q+  G++ + DW+  A   L S     +D   +  +  +L+   S   +++I+M+ +  +
Sbjct: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4244

Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
             E +L+  + E    T+Q  L  +K +W SL    I  + +LEGAL     +Q  + +  
Sbjct: 4245 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 4304

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
             W+   E  L+E +    + +     L K  +L  +VL++ S +E +   G  + E    
Sbjct: 4305 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4364

Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
                  Q +L+ L +R++ + E+ ++   + +  +R  + +  +++  + WL   +  L 
Sbjct: 4365 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4424

Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
                L G   T +  L    E+       +    S++   + ++      AE   D+ + 
Sbjct: 4425 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4484

Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
            +L++ W++ + +L+E +T+    +N         Q    WL  AE+ ++  +R      T
Sbjct: 4485 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4544

Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
               Q+ + K +  EV ++R+++ E+      +   S     +  +     + SR++ ++ 
Sbjct: 4545 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4604

Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
            +++E+ + L++  +  ++   + S   +W   + K+  +   +A   DK+ T     +L 
Sbjct: 4605 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4659

Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
              +   K +   HS+  +    G R++K       + L+  + D + +L++   T+    
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4716

Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
             +    LE+ L  + +F+D  +AL  W+   +  L   +    ++      +  +K+ Q+
Sbjct: 4717 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4776

Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
             +     SV++++     L+E  +D +  +K ++ +L + ++ +C++       LEA ++
Sbjct: 4777 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4836

Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
              E+++S +  + +WL +    L    V PD  +  +L T+  Q   HK  M+++     
Sbjct: 4837 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4891

Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
             LN     GDT++  C       +K  +       +  +  + + A++  Q L   L   
Sbjct: 4892 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4947

Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
            +++Q+ L+   AWL   +  L    +  +      ++++  +AL  + +T+++
Sbjct: 4948 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 4995



 Score =  320 bits (819), Expect = 5e-86
 Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
            HQQ    + ++  D  +   ++Q   G    +  +E+   +     L +S ER+E+   V
Sbjct: 1005 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1064

Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
                   +R    R E  ++ ++R +    +    HE     +  E L  ELE+ K+   
Sbjct: 1065 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1121

Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
               +I  + E    +A+     P  +  L    +++  QV  +  T  + +KT+ +V   
Sbjct: 1122 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1180

Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
                 +  +     + E+E    A+    + ++  IS +K    E++ K      LE+E 
Sbjct: 1181 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1236

Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
            Q     S   F T  E                        +I  +L  +   G+ L+ + 
Sbjct: 1237 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1296

Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
                 L+  I       Q+ E   RKIQ++  E    LA  +          ++ Q  MD
Sbjct: 1297 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1349

Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
             CQ   E  S+ +  +            +  +  V R      A  + Q++ D+    + 
Sbjct: 1350 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1405

Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
            R TAL  L+  +        +RLE+E  S     +    KA   +  +S   +   + E 
Sbjct: 1406 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1465

Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
                    + +S     +K  QL E+L ++         +L L +  ++  D      + 
Sbjct: 1466 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1510

Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
             N L+  V   Q+   LL S S+     L E QT+ ++ + + ++   R +++  +++  
Sbjct: 1511 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1566

Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
               L   +  L     +G  E   +  G  E            +++ Q     L + +Q 
Sbjct: 1567 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1609

Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
             A +L+ +++     + E    +++ +  LIE+ LN+A    + L    E +   LD ++
Sbjct: 1610 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1669

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
            + A         ++ T   A   QL     +I+NLL                        
Sbjct: 1670 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1721

Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
            GT   E D     K A  ++ E    LL++  D +  T +E L +  ++   Q  ++ +Q
Sbjct: 1722 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1777

Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
             +  + + +     L+ + + ++ ++     ++ + +  L+V ++          +L H 
Sbjct: 1778 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1834

Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
             Q +         E+++      + LEN    A  +    T +K Q+        H+   
Sbjct: 1835 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1892

Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
                    DL   T  G  +L   K     D   V T          +V  KL+   DR 
Sbjct: 1893 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1939

Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
            R   S  +       D++      E  S   +  +    +    HL            R 
Sbjct: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999

Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
             E  K  + ++ ++ + +E+L      L +   +L     D+Q    D++ + E   +  
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2059

Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
                  L+    +S  V+  ++++  W   VE SL    Q   N T   + + K   +++
Sbjct: 2060 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2119

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            ++  +QS+I++  E +         +   SL   M  L  +    S    +T A ++E  
Sbjct: 2120 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2179

Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
             K    E++ E  + FL  K  A    D  G   V E   + +Q       + +  L+ +
Sbjct: 2180 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 2237

Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
                + + +H      + + E+    +++F+       + K+A+  C  +L +F+   + 
Sbjct: 2238 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297

Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
            L  WI E  ++       F  E+LG+S +   +       K  E+ KV    + L  L++
Sbjct: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357

Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
            A     +++  +   G +L+ EG     E    ++ LTS           +++L  + K+
Sbjct: 2358 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2417

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
            K+      L + +  +E   +M  W++ +       + T    DT   +    Q+     
Sbjct: 2418 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2474

Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
             E E+K N+  + + +  L    +E     +       L  +   W ++   ++  Q  L
Sbjct: 2475 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2534

Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
            E   +    +   + QL+QW+   +  +    PL   P +         +Q +L E    
Sbjct: 2535 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2592

Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
                 +L A  + +  +  ED S +   +E+L   TQ  D +T    ++   +++ +   
Sbjct: 2593 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2652

Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
              Y   +   +D L     +L     +S    A  ++L    K+K+ I  + ++I  ++ 
Sbjct: 2653 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2711

Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
            +  E L+  VK+       E +  E+ + L    K ++D   + ++ +++L S  A S Q
Sbjct: 2712 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2764

Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
                     +Q    F A L T  ++          L +LE    D +        Q  +
Sbjct: 2765 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2816

Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
                 AE     LK+Q +E       L+T         K+            + +E  L+
Sbjct: 2817 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2865

Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
            +   KA +  +Q      W+   +    +   C D  +  + ++   SLQK + +     
Sbjct: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925

Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
            E   +  N +LS  E+   ++T E    IQ KV    E        LH K+  LEN+  +
Sbjct: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 2977

Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
             K+F EVS E  +      E++ +H+S   L       +    LQ+  + +   + Q++ 
Sbjct: 2978 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 3034

Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
             K  AQ L    + SK       +V  ++ ++  LS    EK S L+  +     F   I
Sbjct: 3035 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094

Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
            +E+     +    LDS      D   L  +         KLEAL++         KM++ 
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3154

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
              E     TSP+ +  I++ L+++      LL      + Q+EG + +   +   +++FS
Sbjct: 3155 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3208

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
              +   E +         E       L   K+   EE+       + +   G G+     
Sbjct: 3209 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3268

Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
              T     + +L D+  R++ + ++  +   + ++ +     +Q  L++   W+   +E 
Sbjct: 3269 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328

Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
            +        +    +  +++ + LQ    + ++ +  +    E +  +  P  + + L+ 
Sbjct: 3329 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3388

Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
            L      W+A  ++      Q   +    +   +  + ++EWL T E+++       +  
Sbjct: 3389 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3448

Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
            +  E Q+ Q K   +++  +   + +  +  Q +       D+  V S++        + 
Sbjct: 3449 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3508

Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
             + +     LL Q L   K F E+E++ +           +W    H     ++  +   
Sbjct: 3509 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3555

Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
             T  + K+   L VL +D+      +  A   G   +K     E   ++ ++     + K
Sbjct: 3556 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3615

Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
            ++T        TLE+ L LA+      + L  W+ + +  L   E   ++  E      +
Sbjct: 3616 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3675

Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
             K L++   +++  + S+ E   ALLELV       L+  + +    Y+ +     + V 
Sbjct: 3676 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3735

Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
             ++A +   + ++        W+ +   +L++   +     +T + QL   K    EI  
Sbjct: 3736 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3794

Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
             +D +++L   G  ++  C++  +  +K+ +   L+    +Y  IC      Y  LE   
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3850

Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
                   +T ++   WL+  Q  +   P P L       + +  R  QE+ R   +L+  
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3903

Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
                 +   KT  + ++ +     +I++K V A  L   + +IK    +  + L +A   
Sbjct: 3904 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 3960

Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
                    DQ L++++R    L        E+   +  +S+ K+    ++  Q    T+ 
Sbjct: 3961 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4020

Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
            ++  ++  +    +     K +    DQ + +    + L  +RE    D+    +   C 
Sbjct: 4021 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4080

Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
            ++  +   K T ++      D E   +    +K+   A +  +  I+ L+++        
Sbjct: 4081 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4136

Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
             ++I      DK +VK+    L   W  L    K +I      ++     Q   Q + +W
Sbjct: 4137 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4196

Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
             +     +A                E LKQ       Q + M+ L   +EL     LLK 
Sbjct: 4197 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 4251

Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
            + +++D+            +Q  L + +   + L + +  R+  L  AL    QF  A+ 
Sbjct: 4252 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301

Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
            +  + +   E  +  ++ +   P  +  ++      Q  +  +Q+ V  +   G +L++ 
Sbjct: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361

Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
               +E S +  KL+ L   + +VL+K   R Q+L+  L   K F  + +    WL   + 
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421

Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
                   L         QL  +  +       E    +L + GQ +L    +   + + +
Sbjct: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481

Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
             +N L  ++  +     ++  K++EA+    E+ + ++     L++ E Q L ++  P+ 
Sbjct: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4539

Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
            L ++  L   D  +   +EV    E + EL++     +   Q        + ++ + + +
Sbjct: 4540 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599

Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
             ++ ++  +R   L+D    A Q HE   K+ + LE   KS+  E    N+    +T  A
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659

Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
            + K     L   HS+  +   +G  LK  T   +D           K    +   + +  
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4710

Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
             +     E   + E  ++ S  F   +   +DWL RV+ +L+   PV+ D++L  +   I
Sbjct: 4711 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4768

Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
               +  Q+E+      + AL    +E    +++  S+ ++  + ELS     +     ++
Sbjct: 4769 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4827

Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
            Q  L     Q + ++ V  A  +WL +A++ L+  G   D E A   L   H EF    +
Sbjct: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887

Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
            +  + L +  ++  T+  +  P             +   E+ +A  +   QR++      
Sbjct: 4888 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4947

Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
             A+ +LL+   A  QW +     K +E + + + + +  ++E   F    T    + ++ 
Sbjct: 4948 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007

Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
               +K   +  +S    I  L++         AS L  +G+     T +  +  +  +W 
Sbjct: 5008 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 5067

Query: 5194 RLRAVAQDQEKILEDAVD 5211
            ++  +A ++ + L DA+D
Sbjct: 5068 QVWLLALERRRKLNDALD 5085



 Score =  318 bits (815), Expect = 1e-85
 Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)

Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
            V+    W+D M+  L+ +E   ++L    + L   K ++  +  + S L+  ++    MT
Sbjct: 608  VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666

Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
                  L+L   ++ +R   + AK   T   +   L  LH    R      +WL +++E+
Sbjct: 667  ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 721

Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
               Y   E + +       H   +R+L + + +    Q +   +L       P+ +    
Sbjct: 722  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 778

Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
             RA    +  W     Q  +  + E    F              ++  ++L+  ++ +  
Sbjct: 779  YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 830

Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
            +    R S+    E  + +  +  EE+  Y+  +  +  +A+ I+     NS    + + 
Sbjct: 831  KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 890

Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
              +    Y+ + + + +  + +        + ++ S   +E+ + S        +K   +
Sbjct: 891  PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 950

Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
            +A +I++       + + TL     + +K +   H L+      R     ++K +  GE 
Sbjct: 951  LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1005

Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
            ++    L+    D +E  +E       +   LEK +++ K++             YQE+L
Sbjct: 1006 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1052

Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
               E  + E       +S+ ++++  + + E   ++ +R      +  E++  + +   L
Sbjct: 1053 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1112

Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
            K ++++L+ D   + +  +E  FS  A         SEL  V + + Q   MS   +  D
Sbjct: 1113 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1169

Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
             L+T +L     Q A      +   + EE A   D+ NN++    TL  Q    +  K +
Sbjct: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1226

Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
            Q  HA L+       AI     + Y+  + +   H  + D L   + W +  VQ D    
Sbjct: 1227 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1281

Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
                L   E I K +K++R        ++             V+TT + IQ+ +    +T
Sbjct: 1282 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1326

Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
            +  +L Q + L     EI+  +S++    + A+Q    +K    EL+    + MV   + 
Sbjct: 1327 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1381

Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
               K +  Q+S + II++   L  +     +  +  L  Q++     S     + E+ L+
Sbjct: 1382 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1436

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
              +  H       V   K   +W     S+   T    E   K   + Q  K + E++  
Sbjct: 1437 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1483

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            +K+++ E L      L K      ++   +LE  +K       T  E  N++   F E +
Sbjct: 1484 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1533

Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
            +  +E Q +    +++    +  Q        IC  L   +     LI   +  M   G 
Sbjct: 1534 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1590

Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
             E +  Q                   +++ L K +    Q L  V + T    +   + +
Sbjct: 1591 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632

Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
             +E   L+   +++    C+  Q +LK  Q++        +EL K VT     E EK   
Sbjct: 1633 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1682

Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
            + +L+E ++  +++L       K S R     K ++ +   HF+E        + D+   
Sbjct: 1683 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1742

Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
             L + D+         N + +     A+++ I+ Q        ++  + L++ GQ + P 
Sbjct: 1743 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1802

Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
              E     L + +  L   +   +A ++ K    + +QE +        E+   ++ + Q
Sbjct: 1803 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1858

Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
             L  LEA    ++ + T L       E+ +S +   R I      + EA    +++  G 
Sbjct: 1859 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918

Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
              T    +    K+ H    +  L  +     + L+D    YQ +E     L   L++ +
Sbjct: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978

Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
               SK   E +  + K     L+   +L G +    +    LK+    L D    L P A
Sbjct: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2037

Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
                +  +    G  + L+ ++ E   + +  + +S+  Q  +   LDW+  V++ L   
Sbjct: 2038 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2097

Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
              + LN   +Q+ I K  + ++++      +NA++ K K+         ++ L+  + +L
Sbjct: 2098 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2157

Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
            S    +     +   A + E+ ++ + +  + +    +LE   Q L ++   G DV    
Sbjct: 2158 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2215

Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              L  +M+  ++E   H  +LE LHSL+  +     P+ K  + +K  +L  + + M   
Sbjct: 2216 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2273

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
               + + +  C  Q   +Q   + +   + +T KK+      F       S E  +KL E
Sbjct: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2333

Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
              +L                  +S V +  + I A++   + L  E T  +  +   ++ 
Sbjct: 2334 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2393

Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
            +T++ +  T +    +D   +L+D + E     +K++KA E    M+  LQ         
Sbjct: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453

Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
             + P  +  +A K    T +E + +F  EL+Q  + +  L+ +   +L++   P   E P
Sbjct: 2454 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2507

Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
               Q +T +  +   + +      + +++   +    +T    +K W+ E +     LG 
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567

Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
             +I+   ++ Q +++QILL E    +   E++    +    G+ +    + SL      Q
Sbjct: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2623

Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
            LA V      +  Q+ D+   ++Q+   S     Q Q L + L+  L+ L  K  + +  
Sbjct: 2624 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2679

Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
             T    + ++L+       E+    ++             L +   L   L++++  + +
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2739

Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
              +   ++AEN +  L  A +   ++ +M      W++  K         N +  +  + 
Sbjct: 2740 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2793

Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
             + ++L+++ K+    L A +   +   +    E  +  +   G E   L+  +     N
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2849

Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
                 K +K+ E +LK+   +LE+A           L  KEQ+   + L   ++  +  +
Sbjct: 2850 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2892

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
            + ++ C       E+ +A L        LQ+E    QH  + +       +++    +  
Sbjct: 2893 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2943

Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
            E    E K L Q ++    ++  K     N+       QE+  +  R  + A++     +
Sbjct: 2944 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3003

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
             + S     K LTM       L  +     LA+              GT D+  ++    
Sbjct: 3004 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3063

Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
              H ++      +C  L + +      + T  E+ S  A       S +PV     ++ +
Sbjct: 3064 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3123

Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
                  A+ + L A     D A        + E   P L       L  L +    L + 
Sbjct: 3124 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3182

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
               ++  +   ++R +++   L+  S     I L+ +E  E  + P   E++    Q  M
Sbjct: 3183 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3237

Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
             ++   ++EI  LQ        L + L+  + ++   +   L+  L  +  R  T+  K 
Sbjct: 3238 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3294

Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
            + +   L+E L   L   R + AL+        L SW++ T+  +     P  E   ++A
Sbjct: 3295 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3344

Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
            Q         L+D +   VE+                KV  L +LS+ +     L  KA 
Sbjct: 3345 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3404

Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
            T++         R+L+G  +  Q+  H+  + LN   T  EK   + +   TQ+  ++E 
Sbjct: 3405 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3454

Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
            +AQ +          +   K L Q ++  +SL + ++SR ++ ++Q           E  
Sbjct: 3455 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3509

Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
              +  + ++L Q L     K   ED++  M W   +H        Q++ST+    Q + L
Sbjct: 3510 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3567

Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
               QE +L  + N    LL+G+ L K      +   +   L+ +   +++++  S    +
Sbjct: 3568 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626

Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
               Q++ L ++L+       TWLD VE  L  +    L  EE        + L K+ K  
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686

Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
               +D + N  S A  E        G  + V ED       R  L+   + Q+  ++   
Sbjct: 3687 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3740

Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
            + +                          +  F+Q    ++  I + E  L       +E
Sbjct: 3741 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3774

Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
              +   +LQV++    E+ + +D+ D+L+       +  ++    ++K + ++ L++   
Sbjct: 3775 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3834

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
            + +   E+            E  Q L+++  E ++ L     LTET  + IIS       
Sbjct: 3835 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3875

Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
                +L A A             LEY  ET       QQE  RQL           L+ E
Sbjct: 3876 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3903

Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
            ++  +             +N+  P+L + L  G+   I       ++  +Q+ E      
Sbjct: 3904 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3945

Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
              + K    L+  +   T++  +   ++  L+   +RL    +Q  ++  E+E +++ ++
Sbjct: 3946 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4000

Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
                 S +++    L  ++   G +++       K +    ++ +L ++   W ++ T +
Sbjct: 4001 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4060

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               + KL  L + +L  +      MS I  +++      D     I    + +  +  + 
Sbjct: 4061 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4117

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
             + +I+  Q  +D V    + + S+ + +    DK    + +  +N +W  L     ++I
Sbjct: 4118 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
              LE  +++  +Y++ +Q +  W +    +L     IG D  +V+  +++ +  +     
Sbjct: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233

Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
            ++ E+E++      L++   E+     V   L EL   W +L+  +   +  L+  L   
Sbjct: 4234 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4293

Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
               + A D++ ++L      LS  + + G  +A+++++     LQ+D+   + +++    
Sbjct: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4353

Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
              N L++         L N L+ +N RW N+LE+  ++ Q     L+   + K +  +  
Sbjct: 4354 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4410

Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
               Q   D    LL +       + A +++   ++ C        T K     L + G+Q
Sbjct: 4411 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4466

Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  +   SA + I  D  +L +   ++E  L +++T L+  +     F  SL+    W+ 
Sbjct: 4467 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4526

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
            +AE+ L       S  L T+  +++E K    + +S    +  L++ G  L      +++
Sbjct: 4527 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4585

Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
              ++NL       W  +  +  ER   L     + + F E     ME+L ++E+ L   +
Sbjct: 4586 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4645

Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
            EI+ +   +  Q   H+ FQ  + ++  +  +    G+ L E+  + DD  + +  L+ L
Sbjct: 4646 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4705

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
             ++W  +  ++ +R+  ++  +    ++ +  + L  WL  V    ++    V   +   
Sbjct: 4706 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4764

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
              L D      K F ++ G    +V+A K+    L+       + ++ ++ E+  +W++ 
Sbjct: 4765 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4820

Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
                  ++ +L   L+  E+    +   LE L   ++ L     LPD  + L     + K
Sbjct: 4821 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4880

Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
            E    +     +L + + + DT+ A    D I+ +   + +++ ++EE+       +Q++
Sbjct: 4881 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4940

Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
               L       E  + L  WL   E+ ++     +I + IE++K      + + EE+   
Sbjct: 4941 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5000

Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
            Q +  ++ +  +R A       SH                         ++IE K  +VN
Sbjct: 5001 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5060

Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
                +WQ +  L   R +KL + L  +++L
Sbjct: 5061 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5090



 Score =  298 bits (763), Expect = 2e-79
 Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)

Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
            E+EK  K  E +  DL           S A  S     ++  L      + ++YS    Y
Sbjct: 1108 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1167

Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
                +  N  L++   A+ L++L    L  E A        ENL S ++ + +E      
Sbjct: 1168 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1227

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
             FH+  +EL    A  D + K   + DL+     +K   L  R Q +      ++  L+ 
Sbjct: 1228 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1287

Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
              +    + D     ++ I+ +  T++K+ E    +  +S     +L++ K LVS +   
Sbjct: 1288 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1344

Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
              K+   ++ A Q   T  D    T++ R+M    Q+   + R +    + I+++ +D  
Sbjct: 1345 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1404

Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
            T +   V   T+ I    D L     E+ S  E     + H     EL++  S +     
Sbjct: 1405 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1457

Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
            +TL   +    P   ++    +EI+  +++     + +     K   K+  +E  + E  
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517

Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
            V+T   S      E+ + L       D ++EE            + + +  +E KEK  G
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1565

Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
            +  +L          + +  + +  ++LK     Q+++++  Q  A         T   L
Sbjct: 1566 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1625

Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
                +KL+++   +    L + K K + + ++A+  +K L + +     +  E  AAV++
Sbjct: 1626 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1685

Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
              E   ++   L     + K +E     H+Q I Q      +     S + E +E+   +
Sbjct: 1686 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1744

Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
            L+     +V   GT   N   Q ++    H+ ++ + + +       + + EK     S 
Sbjct: 1745 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1801

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
               EK+ + + EL    E      + +++      ++++KF+A+  + +  L+Q++  L 
Sbjct: 1802 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1861

Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
            + E G          LK Q S  + ++S    L+       + ++  +S  +     V +
Sbjct: 1862 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1921

Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
                    R  + A+    +   +CN++    +  V +Y+ YE     L           
Sbjct: 1922 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1970

Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
                   + +Q  +A  S+H  E +A   K  Q Q+    +      ++ + ++  + V 
Sbjct: 1971 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2018

Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
            +++  AE   D  G LLP  +     +    GR   L   V E             S ++
Sbjct: 2019 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2078

Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
            G         N E S     + P         ++++I   Q ++  +   +A  ++    
Sbjct: 2079 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2136

Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
               E  +P    S  AK+ DL   +    +   E    + E   + + +++  + + T +
Sbjct: 2137 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196

Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
            E     L+E   PG+         Q    E L  +  + E+  SL +E+ S    +D A 
Sbjct: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2255

Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
             L   + L+   + M  TI+ K              Q+L + L   ++E  ++  + +  
Sbjct: 2256 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2315

Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
              A++L   L  TK   +       E   +    +   N++  +     A++  +V +  
Sbjct: 2316 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2373

Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
             +L G+    +  E  A K L  +K  + ++     D  L ++    E     S +    
Sbjct: 2374 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2433

Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
             +S  + +WL +   T T+ +Q+            ++Q K  E EL +  + ++ +  + 
Sbjct: 2434 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2493

Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
             E+L      E + D  E P         D   QEL         + E+SS         
Sbjct: 2494 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2547

Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
            E+  +++  +++L+ +VL            +++Q Q+L          Y +      G+ 
Sbjct: 2548 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2607

Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
               G+ P+  +  V   L  + Q ++ ++ Q         Q+I    +    + + S  L
Sbjct: 2608 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2666

Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
             D++ +L  + A+    T     NQ++      +   + +K +   +QA  E+     V 
Sbjct: 2667 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2722

Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
            E+ L   L R    +L S   V Q+     + LQ      +  + +        ++  +K
Sbjct: 2723 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2780

Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
                   P++ +++ ++      K+F   +       +K   E  ++             
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840

Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
             +L+ ++  +D     +  R + L ++L    +Y+  ++ L   ++  Q  +   +  + 
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900

Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
             ++ E  I +L    KE  Q      +L  T    +    + KE  T  +  L+ +   V
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2960

Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
             ++ H +   LE + + +    E  +E  RQL+  +  +    S+G    +   L    T
Sbjct: 2961 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3016

Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
            + Q  + SL   + ++       + L++  S     SD+  Q+  + +   + + ++ ++
Sbjct: 3017 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076

Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
               LET L+    +Q+   ++        D L+        V ++ E ++        F 
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3132

Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
            K+++A  +   +   T   +L  ++   D   ++ +L  +  Q   LL    A +E++  
Sbjct: 3133 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3192

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
              + +L   +  S++  +  L++   + +E      +  + I++ L  +K F+ +    +
Sbjct: 3193 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3249

Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
              KQ  V+++ Q ++Q +++   ++  +       L  +N  W+ L   V ++   L+  
Sbjct: 3250 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3304

Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
            L     +++ ++ L +W  +T+E    Q+    +   V+  +++ + L+ L+  ++  VE
Sbjct: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364

Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
             I++ G  +    +      ++  L  L   W  L +        L+ +           
Sbjct: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424

Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
            + +N +L      L     +      ++ Q+   + L+DD+    + L +  SI  Q LK
Sbjct: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3483

Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
                   + +  +  + +  W     EI E+  S   LLQ                  + 
Sbjct: 3484 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540

Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
            +      S +  Q+  T  L K  +   +  +++    Q+ +  LL GL  +K    D +
Sbjct: 3541 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600

Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
              + +  E +K +      +    A  ++   L L++ L +  + LC     ++  +L Y
Sbjct: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3659

Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
            ET                ++L+G++ S +      Q R +ELK +     ++   LD LN
Sbjct: 3660 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3694

Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
            E+   L    P   +E   K +   N  + L+S   T++  ++ + +L+ Q F +  +  
Sbjct: 3695 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3754

Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
            + ++ +TE+KL    +I         Q +  + F  E+   + I+  ++  G +++    
Sbjct: 3755 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3814

Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
             +++     KL  +   +  + +   +R   ++       ++ E  E+L  WL E   + 
Sbjct: 3815 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3873

Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
               +  +P P  +  TL  + +   ++   + +   +I  +      LL    G      
Sbjct: 3874 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3924

Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
             E   IQEK+ +A     +++E  KK A  L +         D ++++    +++ + L 
Sbjct: 3925 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983

Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
                 + AE  + KE  +   + + D+ +L  L +TL        A     D  I    +
Sbjct: 3984 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
             ++++ +   WE +   +  R  ++ + +     F   +  L   +   +  +    D  
Sbjct: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102

Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
            I+  + K +++     +EEI   QE    +  +G  L  A  E     ++  + ++N  W
Sbjct: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162

Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
              L      R+ KL+E + A  Q    + ++  W+     +LA   PI  D    E +++
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4219

Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
            ++ E ++ + +  +    +  + +  E+LL        +++  ++Q     L   W ++ 
Sbjct: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4276

Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
               + R+ K+E       +F         WL  +E   +     G      + EL K   
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4336

Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
             Q  V    + +E +NK    L   +  + A +L+  +   NQRW N+ ++     ++L 
Sbjct: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396

Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
              + Q + F    + +  WLT+ +  L   +        AK +QL    +  +    K E
Sbjct: 4397 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4455

Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
                ++ +G+Q++ +        I+++++ L+   + V                   E  
Sbjct: 4456 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4496

Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
            L++R+ +LE++  L+ + +H+   D +    Q    L+++    L            +D+
Sbjct: 4497 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4544

Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
            +  + D     + ++ S   + +   D+ G   K F  +  V L  +      S  E  +
Sbjct: 4545 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4603

Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
            ++L   G++LDD+R + +Q         E +  S+     EL+ +            +K 
Sbjct: 4604 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4663

Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
            + K LG   S  D+  R    LKE+       + L   +   + + D+W+ +  +++ ++
Sbjct: 4664 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4720

Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
             ++++ L    QF   L ++  WL   E +L + Q +    DI  +   I   K  QK +
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4778

Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
              R + + ++   + E  +    +S  ++ ++ +++ RW+ VC+L    +  L+ AL Q 
Sbjct: 4779 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4838

Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
            + FH + H LL  L   ++  R + ++P D +     L D HK+ M+   +L E +  + 
Sbjct: 4839 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4894

Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
                M   +L           K  + +I  R + +L    +H + L   L    ++Q+L
Sbjct: 4895 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4953



 Score =  290 bits (741), Expect = 6e-77
 Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)

Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
            S L S+ S LE  K   +  E      E+ +KEA  SEI +    K    ++   ++ Q 
Sbjct: 629  SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 684

Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
             KL +T     + ++ +     +F S      +W+ EKE+E  A + S    +  I++ K
Sbjct: 685  AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 738

Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
                  ++E++ K  +I  ++E A+   Q +     AR  I+A    ++     + +  Q
Sbjct: 739  DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 795

Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
            C+E     H+ +   + E     +++     + K A+  K  C  ++  +K+   +QE M
Sbjct: 796  CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 851

Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
            +  + L    S I      A+ ++     N D  ++ +  ++     +Q E  + +  E 
Sbjct: 852  EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 911

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
              A  +  A W+ +    +  +           + E    A+R+  E + Q +  L +E 
Sbjct: 912  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 969

Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
                  VVS     +++ +++ S  +VAS   +K M     +  L  L  R+ D  +   
Sbjct: 970  HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1021

Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
               +  +S V       +L    +V  K +  EL  ++E    +  V    +  + +EV 
Sbjct: 1022 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1073

Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
            + +  L++ +  L + + +    +DLH    +  +  +L +E  ++ +      +   EF
Sbjct: 1074 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1133

Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
                A+ S +      L  + Q +    SM+    D + K +N  L+N +A E A V L 
Sbjct: 1134 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1190

Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
                   Y  K+   E           +  +   I+NL+ T +   SE D    +  A +
Sbjct: 1191 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1233

Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
            D+ ++  K+I D   +T KER       KE   Q +++   V  Q+++ L         L
Sbjct: 1234 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1285

Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
            +   K +      + P +D  I ++E T    +R I ENQ +    +      Q +    
Sbjct: 1286 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1340

Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
             +   SK+ E          T+KD E     +     ++ K   K++ +    S    ++
Sbjct: 1341 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1397

Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
             E   + +   +LV T M   +    D  ++LEE    L        + +    E++ W 
Sbjct: 1398 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1453

Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
            +N              P   + IS+ +   + E+L +  ++     A   +++  +  N+
Sbjct: 1454 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1513

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
            L++  K L+   +L F E+  +++L+ ++   +V K   K    +  + ++ +  I    
Sbjct: 1514 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1570

Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
            T+ E  L+   +     +    LKK +  Q+ELQ      +     +      +     E
Sbjct: 1571 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1630

Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
             L +    LI  K +EA     QL  K + S +E L+K  + +++E  E     K   + 
Sbjct: 1631 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1689

Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
                           + S+R G    +V+E      Q                N+L++  
Sbjct: 1690 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1749

Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
            DGQ                       S+  AV   TQ  Q L      +LS +    +Q+
Sbjct: 1750 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1809

Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
             + +    ++  L +  K  +       EL  F+  + +   W+ + E+    ENL    
Sbjct: 1810 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1867

Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
              I     ++ + + F         S D +S +G L  ++  G+   +  + CS+     
Sbjct: 1868 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918

Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
             +     +E  R    A     +L      +   +K + D+    E      L      E
Sbjct: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978

Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
               S+     +      ++  +   K  Q   SS +     ++   E L +    ++ + 
Sbjct: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2038

Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
               Q TL+ ++ ++ D  +  N+     E +   +   L  Q GL E    + +++S L 
Sbjct: 2039 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2095

Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
            E      ++ AL  +I+K+  L                    + +T D S   + Q ++K
Sbjct: 2096 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2155

Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
                +F++     KE + K+EE+     ++ +   +   +L +  + L        D + 
Sbjct: 2156 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2215

Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
             +Q       E ++ ++     L  + SL  E+  +   S   L+  +   L   +K+ E
Sbjct: 2216 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2271

Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
            D++ + +    SC E L                   ++ + +  F  +   L ++LE   
Sbjct: 2272 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2329

Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             L + W+ +                L+    T  + +     G  +L+  +     TE+ 
Sbjct: 2330 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2388

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
             +    L    +D++  S     L      L L+      N +    Q+ ++      QW
Sbjct: 2389 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2442

Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
            L  +N   T  +    P +   V T +++ + F +E +   +K+  +  K  ELL     
Sbjct: 2443 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2502

Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
              +A   +  +T     W+  +     ++  LE     +  F+     ++ WL + E MV
Sbjct: 2503 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2562

Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
                    D      ++Q++Q +L+E    +PQ  +L    Q +        S R     
Sbjct: 2563 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2622

Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
            +++ ++ ++ +L+    ++   +D+ + +  Q+   ++ L D ++D  + L S    ++ 
Sbjct: 2623 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2682

Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
               ++ +    + +    Q+++ Q+K+     E +      E +   + +QL+ +   + 
Sbjct: 2683 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742

Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
             +          L+ A +    +Q   R F  W+D+ +   N+S    A+L    +++  
Sbjct: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2802

Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
             K  ++ + + S + E    +G  +      +E    QL+L  ++  +    ++ KE   
Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2862

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
            K ++ +    +Y+  ++    W+ + Q  L++       A   E ++  L+ LQ    + 
Sbjct: 2863 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2921

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
              ++  + +T   ++   + + +   +    +SL Q       +L   +    N+  K +
Sbjct: 2922 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2979

Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
              ++  ++    L+ A+E++    S  ++  SN+    +Q  Q     + + A + +V+ 
Sbjct: 2980 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 3034

Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
                AQ+++ E   S   S +  Q   +   +  L  QV E+  FLE ++Q +   ++++
Sbjct: 3035 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 3094

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
                  +        ++A      +T+   K+ +T++  LK +E     L ++ +   + 
Sbjct: 3095 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 3148

Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
             K +   E        +++++    +Q  +L    +     +E  +   +EF  K K  +
Sbjct: 3149 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 3208

Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
              + + +E         ME      QL+ +K  Q+  +   +   + V   G+ L++   
Sbjct: 3209 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 3268

Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
              T    L+  +D + + ++ L     +    L+  +     +   L+ +  W++     
Sbjct: 3269 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3327

Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
            LVA     ++  + +  Q+   K +   +   +  +  ++ +G+ +    A   +   K 
Sbjct: 3328 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3383

Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
             +   L      + A+ + A+   + LE          +TL+    WL+ ++  L     
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443

Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
                 ++  +Q+   +AL++                       +R   D++ S  D S  
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3503

Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
                  +      + ++Q L  A+   +   E+ +  +E+   L      D   + + ++
Sbjct: 3504 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3563

Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
             SEL        V Q    ++K    QA +N + E + + T  E      ++  +  ++ 
Sbjct: 3564 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3615

Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
            D+ + S ++    E+ LQ  R  H      C  + +V +E  + E   L   +A    + 
Sbjct: 3616 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3675

Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
             + LKK A   +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +
Sbjct: 3676 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732

Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
            K++ +    L      Q+   EL  W  E +  +          D     L        E
Sbjct: 3733 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791

Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
            +   + ++  L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S
Sbjct: 3792 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851

Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
               QF     +    + + +  I       L  + + +Q +  +  +  +  ++  +  +
Sbjct: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911

Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
               G +L+ E++  E   +  K     ++Y  + +    R   L++ +     F +  D+
Sbjct: 3912 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3970

Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
                L++         ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++   
Sbjct: 3971 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4030

Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
               D       + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ 
Sbjct: 4031 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 4089

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
            + +  F+R  + P  +        Q+    I +E+ GL E +D  +N   E   + G+P 
Sbjct: 4090 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 4147

Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
            +P     +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + +
Sbjct: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207

Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
            +      ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +
Sbjct: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 4261

Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
            Q    ELKL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    + 
Sbjct: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321

Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
             + + I+ E+ K  + Q +V +    + A++    +    +    +++L++ L  L++  
Sbjct: 4322 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4381

Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
             ++ E    R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L
Sbjct: 4382 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4440

Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              HME    F + E+ + S +++   ++A        + + +++Q + +L+ + + +   
Sbjct: 4441 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4496

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
               +   L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EH
Sbjct: 4497 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4552

Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
            K   + VNS  E+I+ L++  + L+          +   + +V  RW ++     ++ + 
Sbjct: 4553 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4612

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            L+DA      F+    K  E +++ +  L           ++ T L  H  F   L  + 
Sbjct: 4613 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4672

Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
            S      +   S+          E+  L  +   + D    +++K  T  GK V+++ K 
Sbjct: 4673 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4723

Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
             E +         + ++  W+     Y   P +  D  +  ++ +++    NH+      
Sbjct: 4724 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4772

Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
                 +K LG  T      S+Q    AL    R+ I+    +    K   QELS + + +
Sbjct: 4773 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4820

Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
                 +  T+L+A                EE       L+E  A  ++ L  +G L    
Sbjct: 4821 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4868

Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
               +  L + H++ +++ E + ++LN+A +  +      + + +  I  WI   +     
Sbjct: 4869 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4928

Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
             +AW    Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E
Sbjct: 4929 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 4979

Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
             EE++ +I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 4980 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5036



 Score =  235 bits (599), Expect = 2e-60
 Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)

Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 591  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 646

Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 647  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 692

Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 693  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 747

Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 748  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 798

Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 799  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857

Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 858  LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 917

Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 918  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 976

Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 977  VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1030

Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 1031 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1083

Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 1084 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1142

Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 1143 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1197

Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 1198 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1253

Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 1254 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313

Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1371

Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 1372 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1417

Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 1418 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 1459 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1512

Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572

Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632

Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 1633 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1687

Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 1688 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1747

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1804

Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 1805 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1864

Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 1865 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1924

Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 1925 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984

Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
              +      +  D    +  L + + LQ   +  Q  +  +  T E   D   S +P   
Sbjct: 1985 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2039

Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
            D  + L+ +   ++     ++E   +    + +   ++    ++ +W+   E  +  + +
Sbjct: 2040 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099

Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
               N    +  + +     +++   +  +  +  + ++ ++ +  ++    QA    L++
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159

Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
            R+        + L +++ L+ +++  E     L ++ +               + ++   
Sbjct: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219

Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
            M     + LE   K +E  HSLLK     G  + K L   +   L K       + KE+ 
Sbjct: 2220 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2271

Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
             T++++   +         F    K+L  WI E  + + +  +P     +    L   K 
Sbjct: 2272 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2330

Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
            LQ+      P ++ V   G +L  L+  VT                              
Sbjct: 2331 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2390

Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
                  +K  +  +   Y+DL  + K+ +  L  K+   +    E   + +WL +M+   
Sbjct: 2391 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2450

Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
                  P   +T +++T  +Q                                      K
Sbjct: 2451 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2510

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
             M+ EI      LN L +     + + +++L      +A+LKQ      +   + G    
Sbjct: 2511 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2570

Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
               + +T ++  Q L   LQ+  +R+   +Q  A   A Q  L    + P  R    +Q+
Sbjct: 2571 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2624

Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
                A+ ++  +    L   CD +  A VK+T    Q   +++  KL    N       +
Sbjct: 2625 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2679

Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
                  +   L+ A +  Q +++   +++  +AQ +   +   VK+ +  +A ++  +E 
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2736

Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
            + K  K  E      + HL                   WLD  ++  N            
Sbjct: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2796

Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
               ++  +D  +T      M                      +++ L    T WD   + 
Sbjct: 2797 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2856

Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
              E      E+L+K                            L   E + +I  LK  ++
Sbjct: 2857 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2916

Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
            +M +H  + +             E+ KE  +   +   Q  D++  ++      LE +  
Sbjct: 2917 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 2975

Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
               +F+E  E ++E +  +  A +Q    D   +Q     +L +    +     LK  + 
Sbjct: 2976 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 3033

Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
             A R+  DL      V++ + S   S V    + + Q    L++ + EK  FL    Q  
Sbjct: 3034 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087

Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
               Q   R++   F E    L     V +  +T +  + ++K +  ++  L A      K
Sbjct: 3088 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3147

Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
                   TE+   +++G    L+ L    + +L +   R +++E  +   + F     + 
Sbjct: 3148 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3207

Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
               L++A+     +  +  E+  ++ QL  ++  + Q  E E L    Q     GQ ++ 
Sbjct: 3208 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 3265

Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
            S         L   L+ +  ++  +      +  ++QEA+L    +   +E     + + 
Sbjct: 3266 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3325

Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
            E           +  V +A +  Q   + +LD+       V+ + ++ E   +T +P   
Sbjct: 3326 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3382

Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
             K+L  ++L    +  L  + E R   LE  +   Q+  +  + L   L ++  E+  VN
Sbjct: 3383 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3440

Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
             E +  +  KL+   +   +L+D  I   +       +   L  L+  + +  +QS    
Sbjct: 3441 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500

Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
               W  E++  + +  E + +  C +++     F  +    ++WL  V  +LS     D 
Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3555

Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
            + + + ++  ++++ QE++   LR  N     L+  E  K T   E++   ++  L  + 
Sbjct: 3556 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3611

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
                DI +       TL +     +R +   +    WL+  + ELL      L  E A +
Sbjct: 3612 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3671

Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
                  E         + L+ L+ + + L  L+    +E LE+ VA    R + +S    
Sbjct: 3672 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731

Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
             +V+ +     +   + +A +  +  + +TEKKL     ++     +   +L   K    
Sbjct: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3790

Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
             +    + I  L +   ++    ++  K ++ + +  V + +  +  +  ++   LE A 
Sbjct: 3791 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3850

Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
                 F    ++    + + Q  +    A       L    E H      + + +  +  
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3910

Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
            + +    +L+     +PGE   + ++  A       ++E VK     + + +        
Sbjct: 3911 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3966

Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
            +I+ +   ++   E L  P   I A++E+++  ++E  N   ++EK+       +++ E+
Sbjct: 3967 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4025

Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
             +        ++S +  +  LD  + I + I   ++E E       EL+   +K   D  
Sbjct: 4026 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 4082

Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
            +++  +K   D              V Q +   + + EE+DG   +L  +     + +  
Sbjct: 4083 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4142

Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
             G+  KP+ KK I +L        +  ++R+ KL +A     +Y + L+ +  W++    
Sbjct: 4143 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 4198

Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
            +A G +A  S S +       +  +EE K+  S  EA  ++++        E+++ Q   
Sbjct: 4199 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 4247

Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
            L ++  E     +     +QD   ++K      E  +   Q  LE A   L   +     
Sbjct: 4248 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302

Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
            L   L+H + LLSE + +   PK   ++L +  + +  DV+A      A  +        
Sbjct: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4361

Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
               EEAS LQ+         Q  + + EQ +Q++    +  +G H EIED          
Sbjct: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421

Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
                 KP+     +  + Q++ H E+    +  +E   SL  K + +  +   +      
Sbjct: 4422 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4480

Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
             ++  L E  E ++ +L    +     + +     ++L   +   +  E T +  S    
Sbjct: 4481 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4536

Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
               PS + +T    +++   +   +++ R Q    ++  + +  + F +          L
Sbjct: 4537 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4592

Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
              +Q  WE +   + E+ R+L +A +R +++ ++   +   +E  E  L    E    P+
Sbjct: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4652

Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
               +Q+A+H+    + L  +  + +  +     L  ++  AD  + L L   L+ L ++ 
Sbjct: 4653 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4709

Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
             TI  K+  ++  LEE L   L   +   ALQ        L  WL   +  L     P  
Sbjct: 4710 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4758

Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
              +D+   L+D      +   K  +  +    +   L+EG   ++D++  +  +++ L  
Sbjct: 4759 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4815

Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
                +      KQ  ++   ++ EE    + A     + EWLA+A  T            
Sbjct: 4816 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4870

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
              ++ + Q KE  ++L E+++ L    + G+ +L
Sbjct: 4871 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4904



 Score =  224 bits (570), Expect = 4e-57
 Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)

Query: 500  LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
            L+K +  EL  +L  L    E  S +  W+ K  +  +  Q        +   + +E +K
Sbjct: 2414 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2473

Query: 552  FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
             FE    Q     Q LK      ++ +    EA    + + E  ++W+ L+      +  
Sbjct: 2474 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2533

Query: 608  LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
            LEE  +N  ++    A L+ WL + E              MLN      +   +      
Sbjct: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593

Query: 655  QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
             Q+  +  AG  ++     D  +   +K+QL  +  +W  L  ++       D+      
Sbjct: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653

Query: 712  EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
            +Y   + +LS   ++   KLS  L VS     MN +L     + Q+++  ++++ V  A 
Sbjct: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2713

Query: 762  --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
                  + K  +L  + S Q EG  K       K +  +  ++  C S   ++  S+   
Sbjct: 2714 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2773

Query: 815  IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
              L+  +++    +    K++ + +++ + +  S  L  Q H  ++ +A  EN    L L
Sbjct: 2774 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2829

Query: 872  IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
              +GS+     + L+ +  ++D     +Q+ +     +  ++K   +K+ VET    + K
Sbjct: 2830 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2887

Query: 932  FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
             + +  E++  L  A EG       + L +   + F  ++      N+ L  C+   +++
Sbjct: 2888 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946

Query: 990  PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
             ++ +  +Q+      +LH +   L+          ++  E  R L   +E   +LD   
Sbjct: 2947 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3003

Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
             L  Q  S K +    +  + +      + ++ L + L   L V     D+ GT  V L+
Sbjct: 3004 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3058

Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
             E  A   ST  + +++   + +   +    F + I    +Q      E    A  G   
Sbjct: 3059 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3118

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
              ++       K+ ET+     +L+ L  ++S + A K    +     +   LV +  ++
Sbjct: 3119 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3169

Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
            E   K  +   D  Q +E      +K  LEE  S  KE            + Q    ++T
Sbjct: 3170 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3228

Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
            E + +   +  +  +++ + +  K++DV    Q + Q+           H +L  + +  
Sbjct: 3229 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3287

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
              L +   ++  ++Q  L    RF+   E+++ ++  T    ++++  S +  + + +++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3346

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
            ++ K   +  +      E + +E  +I     P +K  + +Q   +  + + L +  E  
Sbjct: 3347 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3406

Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
             + +E +      F    E L+ W+T  EK L     + T +S ++ QI+Q K    +I 
Sbjct: 3407 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3466

Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
            +    +       QS     +  +   +++KL   + +  E++E +      +   L   
Sbjct: 3467 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3526

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
            + F E+  ++   ++E  DKL+  + +   +TE         +VLQE  D+    +++  
Sbjct: 3527 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3583

Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
            A+       ++    +  +   +  A++ +Y+DI + + +    LE  L   +RL     
Sbjct: 3584 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3643

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
               TWL++ E +  S E  +       + +++  + L+ E  +  +    L ++  +L  
Sbjct: 3644 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3702

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
            +      + ++  + + +ER+R +   I +++  + + +   QQFD+   +   WI    
Sbjct: 3703 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3762

Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
             +L +  +I +   Q +  L   K    E+   K  +  L     K+ +    E+   ++
Sbjct: 3763 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3822

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
             K +   + ++   Q+   R L L    S + +F +++  L   L +  Q++ +      
Sbjct: 3823 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3881

Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
             E + + +   +  Q  + +      +D +       L++   E          AD L  
Sbjct: 3882 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3941

Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
            +++           EA + +     F D+ +++L+S+E I ER  +        + ++++
Sbjct: 3942 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3998

Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
            +     +  ++   +     LK + +++        KD++ A  V  +++++   W++  
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4057

Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
             L+ E + +   +++L  ++           ++ S ++  + T   I+D ED       +
Sbjct: 4058 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4108

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
            K      ET + +++  Q++LD   + G  L++      K I       + +  +S    
Sbjct: 4109 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4168

Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
            W D  +KLEE M   + ++   D + +  D ++  +   +  M+   ++L+   +  E L
Sbjct: 4169 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4224

Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
            K+F+SE   + + +E L+   +  + L K +    D   ++  LM+ KL  +  +E    
Sbjct: 4225 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281

Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
             +  L+       Q +  ++++  W T  E  L          +  E  L K   +Q ++
Sbjct: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341

Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
             + QS + +  +  N L       E  +L   +  L ++ + V +   + +  L  +L  
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401

Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
             K F   +++ Q+W    +     S    G  +  + +L+    +  +    +    ++ 
Sbjct: 4402 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4461

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            Q+GQ + A   K   ++I + I    E++++   +  + K  L++  +    F +  +  
Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4521

Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
              W+ + E+  N  +           + + HKV  F  E+ + RE + +L + G  L  +
Sbjct: 4522 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4577

Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
                 Q+  L   LL S Q+    +++   E+ RS   A +  +   EA   +  W++  
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637

Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
            +  L          D ++ +L+Q ++     G      +     G     ++S  +    
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697

Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
            +   L  L++ W  I   SV  Q+ LE  +     + +    L  W+  V+ ++      
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757

Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
               +     L+D+ ++   E    T ++  L   +REL E   +D S+     +EL T++
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4817

Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
              +  ++  K  ++E  ++    +   VH   +WL  A++ L     +  D  A +  + 
Sbjct: 4818 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4877

Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
            + KE +   E   + L++  ++   V           +   +  +RA   ++E+ +   +
Sbjct: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4934

Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
               + L S +A       G +A+ ++ LE   A L+ WA+  T L  K  D+E++     
Sbjct: 4935 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 4977

Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
             QEI           E++K+ + E   F  +++     V  + K Y
Sbjct: 4978 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5011



 Score =  213 bits (543), Expect = 5e-54
 Identities = 145/433 (33%), Positives = 223/433 (51%), Gaps = 65/433 (15%)

Query: 16  NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75
           +V++R +DE++ VQK+TFTKWIN HL K +    V+DL+ED++DG  L++LLEVLSG  L
Sbjct: 24  DVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTL 81

Query: 76  PCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 135
           P E+GR   R H + N+  AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI
Sbjct: 82  PREKGRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQI 139

Query: 136 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 195
            ++                    V+ E+               +AK+ LL W Q      
Sbjct: 140 SDIH-------------------VTGESEDM------------SAKERLLLWTQQATEGY 168

Query: 196 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRL 255
            GI  ++F   WR G  F+++IH  RP+L+D+ TV  +SN  NLE AF +AE ++G+ RL
Sbjct: 169 AGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRL 227

Query: 256 LDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKRE 315
           LDPEDVDV  PDEKS++TYV+     +P +     +G   +++   +  + N V    + 
Sbjct: 228 LDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQW 286

Query: 316 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQP 371
            R     M       ER      +    L ++Y  FK   +      + K K++  L++ 
Sbjct: 287 IRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEI 340

Query: 372 LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 431
               G++ L Q       ++      +W            G +   +   E ALR E+  
Sbjct: 341 WIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVER 382

Query: 432 QQVHEETANTIQR 444
            ++ ++ AN +QR
Sbjct: 383 LEMLQQIANRVQR 395



 Score =  162 bits (411), Expect = 1e-38
 Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)

Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 1009 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1066

Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 1067 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1126

Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 1127 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1171

Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1222

Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1282

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 1283 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1342

Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 1343 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1402

Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 1403 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462

Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522

Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1582

Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 1583 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1636

Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 1637 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1696

Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
              W+   ++  +     H                                      + T 
Sbjct: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756

Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816

Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876

Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936

Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1995

Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 1996 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052

Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112

Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2227

Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 2228 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2286

Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 2287 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344

Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404

Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464

Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524

Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2584

Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 2585 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644

Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 2645 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700

Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
                    V     E     DLS  ++    +A  S   EG  +  KD   +    +   
Sbjct: 2701 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2755

Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
             SA  S  Q +Q+ +   A  D++ + Q   + I +K      L   +K + K L   S 
Sbjct: 2756 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2815

Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
              + ++   E+ L + + S    + L     +T      W+    Q   +E ++K++L+K
Sbjct: 2816 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2870

Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
              ++   + ++W W+   +  LE+   ++   D    E  I KLK LQK +D    ++  
Sbjct: 2871 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2927

Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
            +N  +         +   + D    +  + D V   L   +  L++   + + F E+S  
Sbjct: 2928 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987

Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
                L    E +D   +      SN    +LQ   K L  +KH++    L     QD+  
Sbjct: 2988 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3044

Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
            +   +++GT   +   +V  I      L ++V      LE KL  +   Q  +    S  
Sbjct: 3045 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101

Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
                DELD+   V    GR     QK
Sbjct: 3102 AEFDDELDSMAPV----GRDAETLQK 3123



 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)

Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
            DL++W   +Q   DR E W     +V   LE  ++   A  EF      +SSLK + +S 
Sbjct: 610  DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 662

Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
                  LK     T   +L R++SQ+  LL N    QE+ H   +    SR A +E++ W
Sbjct: 663  IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 714

Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
            ++      +K+E+ +  +  +   +  + + K +  ++  +    +   +SV +I+ Q +
Sbjct: 715  LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 766

Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
                  +        AM   W  ILQ     +  + E    ++ E+ N+ +    +    
Sbjct: 767  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 824

Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
            +  +++++     +S+         LEDL++   +E E++ Q  + +A +  K + +  +
Sbjct: 825  KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 877

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
                     +T   +  +    +I +    D       +SH+  +  I+    EA     
Sbjct: 878  KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 937

Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
             F +   + EAV +      Q  N+  L  +     +S+  +  + N++ +     V   
Sbjct: 938  CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 997

Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
             T         L  +  R+ + LE+  E Q+ S   + QL        Q Y++  K    
Sbjct: 998  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1057

Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
              Q++                    EDR    ++    +D   + V   I +   L K L
Sbjct: 1058 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 1116

Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
              +KD L  +    E+   Q  A+A+S++ + +  L+  L  + Q      T +   +  
Sbjct: 1117 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 1173

Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
                 K+ +A EA +      +  EE +     +  + +ST+++   E+  +   F ++ 
Sbjct: 1174 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1233

Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
             +L +   +   +    KE         ++   L   W  +  Q   R   L+     L 
Sbjct: 1234 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 1293

Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
             ++      + W++ +  T++K+      N + L  Q    ++  +E+  +Q    S + 
Sbjct: 1294 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1349

Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
            + Q+  EQ     +D     +T                R ++DSQ +   + R M     
Sbjct: 1350 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1394

Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
              + E   L       V +  Q  +   D ++  E+                        
Sbjct: 1395 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1430

Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
               E +L+ E  E  EK K     L++    ++  LKD EK  K        S E++ T 
Sbjct: 1431 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1484

Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
            K++LS++L      L  H ++M  +E             Q+  L+++ +   S       
Sbjct: 1485 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1532

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
                 L Q Q  +    + +  + + ER  E   + EK + +C+ LTQ E+++  +    
Sbjct: 1533 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1584

Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
              GD  +E        E+L+KD Q        + +  +  L++ GE+L+   KA  E K 
Sbjct: 1585 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1644

Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
            +E + K  ++N + +     L  ++   +K+  E + AV+QL+++   + +L  WL++++
Sbjct: 1645 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1704

Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
              SE A    K ++             S   EE                   Q  LN+Q 
Sbjct: 1705 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1764

Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
            +      ++ I +H   + +  +  +VLL       +  E + +Q+  + L   +    A
Sbjct: 1765 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1823

Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
             S E+++K+  + +   +KF  DY+ FE WL+ SE+      +          +LK+ ++
Sbjct: 1824 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1882

Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
            F   V      L  I     R+             + D++ +   +++ +     R+ +L
Sbjct: 1883 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1942

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
              +   +   LK  + + + +E A   +L  L     + T  +H SE       ++Q ++
Sbjct: 1943 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 2000

Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
            ++ KA Q +IS     +E++    E L++    L  A   I++ LD++    +++   V 
Sbjct: 2001 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2060

Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
              ++KL ++ L         R L ++D      L W      SL      P  S+ L   
Sbjct: 2061 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 2110

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
            +++ +  E+      +S+++          ++  ++  M    PS     Q   KD   R
Sbjct: 2111 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 2160

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             +   S  H    +++ +L   ++      ++ +  + +KT    E+D   K   +L   
Sbjct: 2161 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219

Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
               S      LEHK   E   SL   ++ H   +  A V+++   L  +    E  +K+ 
Sbjct: 2220 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 2277

Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
                    ++   F   + S+ +W+ +T ++                LE  ++L+    +
Sbjct: 2278 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2337

Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
            +T E+Q        L  L  AV      I ++     + + E T  +++E         +
Sbjct: 2338 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397

Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
            +  ++ ++  ++ +  LL++    L   L + Q   E S  ++  L+ +++   +     
Sbjct: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457

Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
            +  D E ++   +Q    + EL ++  +V  L+D   +LL   E  D  EA         
Sbjct: 2458 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2507

Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
            R K +L E+    +EL +L       L+ SS+        +  L  W    EL  S  + 
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2566

Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
            P S    PN   T R +  +     +   P            LS PG   S RG +   L
Sbjct: 2567 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2624

Query: 8746 RA 8747
             A
Sbjct: 2625 AA 2626



 Score = 54.7 bits (130), Expect = 4e-06
 Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)

Query: 366  EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
            E ++Q L   G+ SLD A  + + +    S+L +W  + +KSL + L          E+A
Sbjct: 4600 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4648

Query: 425  LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
                           + I+ +L QHK+  ++  A     H +Y T +  G  +       
Sbjct: 4649 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4692

Query: 479  ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
                   D L ++ +++  +   S        E  L   +F +    L+  L   E +L 
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752

Query: 525  SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
                 +G  + V  L+ N+ +F    K   +   + Q LK++A   +  +GS +++  V 
Sbjct: 4753 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4807

Query: 585  KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
              M E + +W  +     S ++ LE  +   + + + V +L  WL +AE+      +L  
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867

Query: 639  SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
             E+A        K+F + L     +       G+ ++  C       +K  + ++  R+ 
Sbjct: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927

Query: 692  ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
            E+    KQ+ Q  A  +  +  K+E  + ++    +A T    K  E +      VK LI
Sbjct: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987

Query: 747  QD----LEDIEQRVPVMDAQYKIITKT 769
             +    +E++ ++ P +D     +TKT
Sbjct: 4988 AEHQTFMEEMTRKQPDVDK----VTKT 5010



 Score = 33.9 bits (76), Expect = 7.3
 Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
            Q +QL+++      A + +E+  LR  C  V+ +      +  +L +      L+    +
Sbjct: 458  QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 512

Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
                +  S L        SL     SS+++  L+  + S  +   TPA     P      
Sbjct: 513  TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 561

Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
              L  +  S +      E    Q  K   +R  +  S   D +  E +I     + L   
Sbjct: 562  -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 614

Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
            +D+ + Q+ +TE    S  P+      ++K   + + E  SS+      E K+ E + + 
Sbjct: 615  VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 667

Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
            P        +   A  + R E   A+ L+     +++L     F S   +   WL + EE
Sbjct: 668  P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
            E       E++ D       I + K    EL + +D ++  I S+   + +    +    
Sbjct: 721  E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 773

Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
              ++   + M  +W  +  L +     +++     + F++       L  L++  +RK  
Sbjct: 774  LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 831

Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
                D +     L+D  ++ M+ K ELL+ +  +A+L   +  ++ +    +DC
Sbjct: 832  -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 884



 Score = 33.5 bits (75), Expect = 9.6
 Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)

Query: 375  DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
            D  L LD  L  ++  WD +  +  +   +L+++L         L  +  WLYR E  L 
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752

Query: 427  EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
            E+  V    +   N I       K+L + T    A KR+  E+      +   V   Q++
Sbjct: 4753 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4811

Query: 484  DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
            +++ R+  V + S     ++        EF  + + LL  L  AE  L+   +     ++
Sbjct: 4812 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871

Query: 536  VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
            +  L+  +  F                +K+  E   + + +    + V+   +     T 
Sbjct: 4872 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915

Query: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
              W      +  +R+  EEV++   ++   +AS  A L            AK++    L 
Sbjct: 4916 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4958

Query: 652  HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
             W+Q       A   L +   E++ +++++   L+     + FME     Q D +D++ K
Sbjct: 4959 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5009

Query: 712  EY 713
             Y
Sbjct: 5010 TY 5011


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  372 bits (955), Expect = e-102
 Identities = 717/4026 (17%), Positives = 1587/4026 (39%), Gaps = 438/4026 (10%)

Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 959  LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1015

Query: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074

Query: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1398
                T    +V    +Y+   G S +R       +SL  E ++  E +K  +        
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1132

Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1453
             +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D   +
Sbjct: 1133 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186

Query: 1454 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1506
              E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L  +
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1566
             ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K   
Sbjct: 1247 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1303

Query: 1567 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1626
                 EDK  +  K+  +     K  Q ++   Q+ + L   +T                
Sbjct: 1304 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1345

Query: 1627 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1673
                A++++ E +  +++ +E +T +ENLL     ++K+           +    T  + 
Sbjct: 1346 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1401

Query: 1674 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1713
            G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+  
Sbjct: 1402 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1461

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
            +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD  
Sbjct: 1462 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1519

Query: 1774 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1828
               F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+   
Sbjct: 1520 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1579

Query: 1829 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
                        K+ +     ++      A D F+       V+      L  L +  Q 
Sbjct: 1580 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1636

Query: 1877 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1930
            +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ + 
Sbjct: 1637 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 1695

Query: 1931 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1988
              A+  L    S    +   + T D + G  E +   +  +  +         + QD  +
Sbjct: 1696 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 1755

Query: 1989 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2048
            E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  + 
Sbjct: 1756 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 1815

Query: 2049 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
             D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  + 
Sbjct: 1816 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 1875

Query: 2108 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2162
             + T   +  KD  +L               Y Q+    F    KHL    S LK+I S 
Sbjct: 1876 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 1921

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2216
                + +D    ++K  ++S+K +E  D ++      + V S +++++ +        + 
Sbjct: 1922 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 1975

Query: 2217 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2269
            + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   + 
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2034

Query: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2328
            TP                AK I  V  G  + +    +T  E+F  +     T +++ + 
Sbjct: 2035 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2076

Query: 2329 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
            + +       L  +KD   EL ++ S +   QE  +++ +        +     T     
Sbjct: 2077 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2135

Query: 2389 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2448
             EAV     KTQ    +S E    +++ + QE                     L+ KL +
Sbjct: 2136 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2169

Query: 2449 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2508
            L                + +   T  A   KQ+       +T+ + ++Q   +  +  +Q
Sbjct: 2170 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2206

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
             L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E  
Sbjct: 2207 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2264

Query: 2569 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2624
              +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A+ 
Sbjct: 2265 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2324

Query: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2682
            +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K+ 
Sbjct: 2325 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2384

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
             A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +  
Sbjct: 2385 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2443

Query: 2743 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2793
               + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        + 
Sbjct: 2444 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2494

Query: 2794 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
            IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + V 
Sbjct: 2495 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2553

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
                W+                    Q  L +IK  +D  E G + +++++SL  E+ Q+
Sbjct: 2554 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2595

Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
                  EL++    +L +  +  ++ V      L   V  +          +  + Q  +
Sbjct: 2596 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2653

Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
            +F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R +
Sbjct: 2654 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 2713

Query: 3031 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3071
            +DL   +    G          + +E++ L  Q  + C   E  LQ         +    
Sbjct: 2714 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 2773

Query: 3072 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3131
             F +F   L +          + +    +   L+K++  ++ ++N      MML+  E  
Sbjct: 2774 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 2833

Query: 3132 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3191
              L+      GI+  + A  +           +E  +E    ++++F    +     L K
Sbjct: 2834 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 2887

Query: 3192 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3246
             E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    +A
Sbjct: 2888 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 2941

Query: 3247 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
            +KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D   
Sbjct: 2942 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3001

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
            ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I +
Sbjct: 3002 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3061

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
            QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E    +
Sbjct: 3062 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3121

Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3475
                   + + K L +++++++  L      G  +       +  + Q +L   Q  Y  
Sbjct: 3122 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3181

Query: 3476 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3532
            IQE++       ++ +   + +  D      WL +  +KL + SV +         ++ L
Sbjct: 3182 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3241

Query: 3533 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
            R LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++  
Sbjct: 3242 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3299

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWHEE 3647
                  +   R +    +++  WL   E E +S  T+        + Q+   ++KK  + 
Sbjct: 3300 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3359

Query: 3648 VTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
              A  D + EV +   E++      +R G +    +   RY+ +   + ++++ ++  I 
Sbjct: 3360 NKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3416

Query: 3706 SLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
              ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     +   
Sbjct: 3417 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKD 3471

Query: 3763 LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3822
            ++    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +F 
Sbjct: 3472 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3531

Query: 3823 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
            +  + L  W+ E Q I+     P +E    + Q  +++ L++ +  H+P +  + + G  
Sbjct: 3532 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3591

Query: 3883 LLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
            LLEL   +  ++++K     + Y  +    K+   +L+  +     ++ ++ ++ + L +
Sbjct: 3592 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3651

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC------ 3994
            +  RL  P  + ++ +E I +Q++ +K +  ++   +     L+ +G+ +I +       
Sbjct: 3652 IVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 3710

Query: 3995 --ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQ 4046
              A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T++
Sbjct: 3711 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIK 3763

Query: 4047 QCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLS 4100
              Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +  
Sbjct: 3764 DTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPD 3821

Query: 4101 NASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM 4156
               VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L +M
Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881

Query: 4157 KRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHL 4214
                ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   + L
Sbjct: 3882 SPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 3939

Query: 4215 NDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4271
             +    W  L  +  N   + E  L     +   ++ +  +L               +  
Sbjct: 3940 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 3999

Query: 4272 AVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLE 4329
            A+ +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  + 
Sbjct: 4000 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4059

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            +  +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H+ 
Sbjct: 4060 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4119

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
            +C+  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  L 
Sbjct: 4120 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4179

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNE 4509
            +AL+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++ +
Sbjct: 4180 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4239

Query: 4510 VTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE 4569
            +  L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F E
Sbjct: 4240 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4299

Query: 4570 DFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTI 4629
             + K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+++
Sbjct: 4300 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359

Query: 4630 LPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     L 
Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4419

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTG 4744
             +E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R   
Sbjct: 4420 RVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4477

Query: 4745 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
              W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+  
Sbjct: 4478 S-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLR 4534

Query: 4805 NEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4859
                LP +E      +  +      L++    L + T   + +     P +    +H I 
Sbjct: 4535 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4594

Query: 4860 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4919
              +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + + 
Sbjct: 4595 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEV 4649

Query: 4920 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4979
            I +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD     
Sbjct: 4650 IPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAG 4708

Query: 4980 ALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLA 5019
              R   ++L    SQ Q             ++ QV+  A       ND L+  +EL + A
Sbjct: 4709 RKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFA 4768

Query: 5020 GNGLDV 5025
                D+
Sbjct: 4769 NFDFDI 4774



 Score =  340 bits (873), Expect = 3e-92
 Identities = 720/4013 (17%), Positives = 1591/4013 (39%), Gaps = 492/4013 (12%)

Query: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
            K++ + L   +L     AE+ +K +  K    E+V   +  ++N +S +        E  
Sbjct: 844  KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 551  KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
            + F   E        ++ ++ K   E  +  D   E+A+ +++       +W+N+ V++ 
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 953

Query: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
            +    LE +  +   Y +T   L  W++  E        NQ EN+K    + N    +  
Sbjct: 954  NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013

Query: 657  HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
               M  +     +   E  S  +K   L       +++ + +     VK+       D +
Sbjct: 1014 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1070

Query: 710  KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
             +E+ D     +A  T     +++ ++ +  ++K L ++ + +E+       + K + K 
Sbjct: 1071 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1126

Query: 770  AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
               I+K  +  ++ GK  F+      E+++  KE  S  L   Q  L             
Sbjct: 1127 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186

Query: 819  ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
            ELEKQ+ +  +S   +        +E+Q+S   K + + +   Q+  K+ L         
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246

Query: 871  ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
                        +I  G+  ++K+ +    L+  D     + +A++    ++ +K+ G+ 
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1305

Query: 919  -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
                 K  +E           +L  K E+S+ EL+KV+  A +E  E+    ++L    T
Sbjct: 1306 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1365

Query: 965  EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
            +  + LD      +L   D+ ++    + +Q +++     H Q  D       + E   +
Sbjct: 1366 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1417

Query: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
            LL   +D +    + + +E   +  ++ K       EKII +H+ V  + +    L EK+
Sbjct: 1418 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1469

Query: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
             Q +  EE   K  ++  +++        L E    +  T+  L E+ +K+  DYT    
Sbjct: 1470 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1521

Query: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
            EF  W+  +E +L+ ++  A D      ++KR      + ++ +G+      S  +VL  
Sbjct: 1522 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1581

Query: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
              S         + +    +   KL  +     +L S+   + +N  D V   +  +++ 
Sbjct: 1582 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1641

Query: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
              L++G +  +  A K L +E +    + L    ++TK +  +    Q  + + ++    
Sbjct: 1642 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 1700

Query: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
            L D     L     ++ TLD        L +S   +  ++Q+TL +    +   + ++ +
Sbjct: 1701 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 1760

Query: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
            +    SS +      L+ ++L+  +S  +   ++ + R  SI    E  VK+  E    P
Sbjct: 1761 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 1818

Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
                 LQ + K +  +  +     +E +  ME +KTK + F +  E L  ++  K + L 
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 1878

Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
             ++     +      ++ +  E       +  L    +  +      + A +  K   + 
Sbjct: 1879 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 1938

Query: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
            +  +E+ +  +  +  +     Q   F+  ++ ++  + E                    
Sbjct: 1939 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 1998

Query: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
             ED   +  K      E  KV    + LC  + ++++   A +A  S   V+N +     
Sbjct: 1999 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2058

Query: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
                       S  ++   +   YED+    K++   L   L+  Q+ ++E S+ + WL+
Sbjct: 2059 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2118

Query: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
            +    A+  +      D  A + +VE        L+  V        KL +L E      
Sbjct: 2119 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2178

Query: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLF 1784
                 K M   L ++D +W++L Q+   R   L+       QF  +      W+   +L 
Sbjct: 2179 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2235

Query: 1785 LSELQTTS-----------EISIMDHQVALTRHKDH------AAEVESKKGELQSLQGHL 1827
            +S L   S           ++ I+  + A TR   +         + S+ GE  SL+G +
Sbjct: 2236 VSVLGPLSIDPNMLNTQRQQVQILLQEFA-TRKPQYEQLTAAGQGILSRPGEDPSLRG-I 2293

Query: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA---------------- 1871
             K       +    L G+  D     ++A     + Q  L  L+                
Sbjct: 2294 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2353

Query: 1872 --------EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAA 1923
                    + L++   +   ++Q ++ ++   ++ ++ S L++++   A + ++ LE   
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGIL 2412

Query: 1924 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD-------AL 1976
             S   +  KA+ H+     +   S  A++ Q        Q  L TK+ E +        L
Sbjct: 2413 KSFKDVEQKAENHV-----QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2467

Query: 1977 AVLKKAFQDQKE--ELLKSIEDIEERTDKE------RLKEPTRQALQQRLRVFNQLEDEL 2028
             VL+   +D K+  + L +   + E+T  E      + +   + ALQ +L       D  
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2527

Query: 2029 N----SHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE---VTWDDTK--------RL 2073
            N      E++L    +KA +  ++     P +D+  N LE      D  +        + 
Sbjct: 2528 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2587

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSK-----VLENASSVIVTRTTIKDQ--------ED 2120
            + +   Q  G+++L+    N   +V +     V +   S+I     + +Q        E+
Sbjct: 2588 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2647

Query: 2121 LKWAFSKHE----TAKNKMNYKQKDLDNFTSKGKHLLS---------------------E 2155
            +   F + +     +K ++   ++ LD   S G    S                     +
Sbjct: 2648 MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 2707

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
            L K  + D  +  +D + T D  L V E + +    L   +      L T+ +  G   N
Sbjct: 2708 LAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQN 2766

Query: 2216 CVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2268
             + +M    +  D+ L       R  E L++ +  +K    +LE L +  ++  +  K +
Sbjct: 2767 TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM 2826

Query: 2269 ----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVE 2324
                ET PDL  I+ DL    +   ++ + A+       A+  QVE  I  +  +++K++
Sbjct: 2827 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTIKRLEEFYSKLK 2879

Query: 2325 E---SLMNCAQNETCEA------------LKKVKDIQKE----LQSQQSNISSTQENLNS 2365
            E    L    ++E  +             L   K  QKE    LQ +Q +++   + L  
Sbjct: 2880 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQ 2939

Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFL 2423
               K  S   + L   +  +  + + +++  ++  A LQE+L     F ++++    W +
Sbjct: 2940 SAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMV 2997

Query: 2424 GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2483
              +         + + KV++A++ + + +   + D +S ++ + +EG+ +          
Sbjct: 2998 DTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057

Query: 2484 SIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTEN 2542
             I +Q++  +  ++A L +     + L+  +     F +    LN W+  +E+R  N E 
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117

Query: 2543 LGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEG 2595
            +G     + E+       ++++      L + ++  +SL  LS R      E     Q  
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR------EDKDMVQSK 3171

Query: 2596 RLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
               SQ+   +  +   +  +    Q AL   +   E    +  W+  + D+L+       
Sbjct: 3172 LDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDY 3229

Query: 2656 SKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLK 2711
            S + L K+ S++    +DILL K      ++ A+  G + L+ +  +   +IQ +LE +K
Sbjct: 3230 STEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3285

Query: 2712 EVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI----------EHPLQ 2761
              + DI   S     TLE  +           +L  W++ V+ ++          E   Q
Sbjct: 3286 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3345

Query: 2762 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESFKDTAQEELKTQ 2820
             Q   KE      + +++L    + + AL  L+  ++RE  EK   E            +
Sbjct: 3346 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED---------NER 3396

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            +  +     +K+ +++  +     +  A      W+   +++L    D+  +   T  +L
Sbjct: 3397 YRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQL 3456

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
               K    + EI   +         ++  +   SG ++M    +  +   K+  D V + 
Sbjct: 3457 QVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3505

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD-EEIVECW 2999
               +  + S+  L  +     V Q  +  E+    L      ++ L     + E + +  
Sbjct: 3506 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3565

Query: 3000 HKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY---NCLCLQASK 3056
             + +++ + + + +P  + +     +L   S       G+   + ++Y   + L  Q  +
Sbjct: 3566 EEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLYSQIKE 3619

Query: 3057 GCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3116
              + +   L +   ++   F   +     +  +  +  +    +S  ++KI+E +SE++N
Sbjct: 3620 DVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 3678

Query: 3117 GQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDWKNFHSNLHQKE 3165
                +  +    E L      ++ +         AK +Q K+      W+N H+ + ++E
Sbjct: 3679 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738

Query: 3166 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHC 3225
            + L ++    + F      +   +  T+  + +  +   D    +++Q+  +++ EEI  
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDG 3798

Query: 3226 YEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHN 3283
             + +L+ +     +L    G+      +  + +L+S + +L+   K+++ +L+  +    
Sbjct: 3799 LQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAV 3858

Query: 3284 QFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
            Q+  G++ + DW+  A   L S     +D   +  +  +L+   S   +++I+M+ +  +
Sbjct: 3859 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ 3918

Query: 3344 GESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
             E +L+  + E    T+Q  L  +K +W SL    I  + +LEGAL     +Q  + +  
Sbjct: 3919 AELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELL 3978

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYV- 3461
             W+   E  L+E +    + +     L K  +L  +VL++ S +E +   G  + E    
Sbjct: 3979 AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAG 4038

Query: 3462 -----TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD 3516
                  Q +L+ L +R++ + E+ ++   + +  +R  + +  +++  + WL   +  L 
Sbjct: 4039 EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL 4098

Query: 3517 QYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALE 3573
                L G   T +  L    E+       +    S++   + ++      AE   D+ + 
Sbjct: 4099 ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN 4158

Query: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
            +L++ W++ + +L+E +T+    +N         Q    WL  AE+ ++  +R      T
Sbjct: 4159 NLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT 4218

Query: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLL 3691
               Q+ + K +  EV ++R+++ E+      +   S     +  +     + SR++ ++ 
Sbjct: 4219 VLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQ 4278

Query: 3692 QVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLK 3748
            +++E+ + L++  +  ++   + S   +W   + K+  +   +A   DK+ T     +L 
Sbjct: 4279 RLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKT-----QLA 4333

Query: 3749 TLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV---- 3804
              +   K +   HS+  +    G R++K       + L+  + D + +L++   T+    
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSELRDKWDTICGKS 4390

Query: 3805 RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQ 3864
             +    LE+ L  + +F+D  +AL  W+   +  L   +    ++      +  +K+ Q+
Sbjct: 4391 VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQK 4450

Query: 3865 TVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVK 3922
             +     SV++++     L+E  +D +  +K ++ +L + ++ +C++       LEA ++
Sbjct: 4451 ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALR 4510

Query: 3923 DHEDYNSELQEVEKWLLQMSGRL----VAPDLLETSSLETITQQLAHHKAMMEEIAGFED 3978
              E+++S +  + +WL +    L    V PD  +  +L T+  Q   HK  M+++     
Sbjct: 4511 QAEEFHSVVHALLEWLAEAEQTLRFHGVLPD--DEDALRTLIDQ---HKEFMKKLEEKRA 4565

Query: 3979 RLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKH 4038
             LN     GDT++  C       +K  +       +  +  + + A++  Q L   L   
Sbjct: 4566 ELNKATTMGDTVLAICHPDSITTIKHWITI----IRARFEEVLAWAKQHQQRLASALAGL 4621

Query: 4039 VSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4091
            +++Q+ L+   AWL   +  L    +  +      ++++  +AL  + +T+++
Sbjct: 4622 IAKQELLEALLAWLQWAETTLTDKDKEVIP-----QEIEEVKALIAEHQTFME 4669



 Score =  320 bits (819), Expect = 5e-86
 Identities = 790/4278 (18%), Positives = 1616/4278 (37%), Gaps = 541/4278 (12%)

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1337
            HQQ    + ++  D  +   ++Q   G    +  +E+   +     L +S ER+E+   V
Sbjct: 679  HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 738

Query: 1338 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1387
                   +R    R E  ++ ++R +    +    HE     +  E L  ELE+ K+   
Sbjct: 739  YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 795

Query: 1388 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1447
               +I  + E    +A+     P  +  L    +++  QV  +  T  + +KT+ +V   
Sbjct: 796  DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 854

Query: 1448 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1507
                 +  +     + E+E    A+    + ++  IS +K    E++ K      LE+E 
Sbjct: 855  TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 910

Query: 1508 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1540
            Q     S   F T  E                        +I  +L  +   G+ L+ + 
Sbjct: 911  QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 970

Query: 1541 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
                 L+  I       Q+ E   RKIQ++  E    LA  +          ++ Q  MD
Sbjct: 971  DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1023

Query: 1598 LCQAL-ESLSSAITAFS-----------ASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1645
             CQ   E  S+ +  +            +  +  V R      A  + Q++ D+    + 
Sbjct: 1024 ECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL----RT 1079

Query: 1646 RQTALENLLAHW--------QRLEKELSSFLTWLERGEAKASSPEMDIS-ADRVKVEGEL 1696
            R TAL  L+  +        +RLE+E  S     +    KA   +  +S   +   + E 
Sbjct: 1080 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1139

Query: 1697 QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKR 1756
                    + +S     +K  QL E+L ++         +L L +  ++  D      + 
Sbjct: 1140 AGKPPFSKQKISSEEISTKKEQLSEALQTI---------QLFLAKHGDKMTD------EE 1184

Query: 1757 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESK 1816
             N L+  V   Q+   LL S S+     L E QT+ ++ + + ++   R +++  +++  
Sbjct: 1185 RNELEKQVKTLQESYNLLFSESL---KQLQESQTSGDVKV-EEKIVAERQQEYKEKLQGI 1240

Query: 1817 KGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1876
               L   +  L     +G  E   +  G  E            +++ Q     L + +Q 
Sbjct: 1241 CDLLTQTENRL-----IGHQEAFMIGDGTVE------------LKKYQSKQEELQKDMQG 1283

Query: 1877 HA-SLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKAL----ESAAVSLDGIL 1930
             A +L+ +++     + E    +++ +  LIE+ LN+A    + L    E +   LD ++
Sbjct: 1284 SAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1343

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL------------------------ 1966
            + A         ++ T   A   QL     +I+NLL                        
Sbjct: 1344 TTA--------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1395

Query: 1967 GTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2023
            GT   E D     K A  ++ E    LL++  D +  T +E L +  ++   Q  ++ +Q
Sbjct: 1396 GTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1451

Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT-------KRLIHE 2076
             +  + + +     L+ + + ++ ++     ++ + +  L+V ++          +L H 
Sbjct: 1452 HQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTHS 1508

Query: 2077 NQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRTTIKDQEDLKWAFSKHETAK 2132
             Q +         E+++      + LEN    A  +    T +K Q+        H+   
Sbjct: 1509 LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG-- 1566

Query: 2133 NKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRL 2192
                    DL   T  G  +L   K     D   V T          +V  KL+   DR 
Sbjct: 1567 --------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHR-----EVQRKLDHATDRF 1613

Query: 2193 RVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISNLDNHL------------RA 2233
            R   S  +       D++      E  S   +  +    +    HL            R 
Sbjct: 1614 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1673

Query: 2234 EELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEIT 2292
             E  K  + ++ ++ + +E+L      L +   +L     D+Q    D++ + E   +  
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 1733

Query: 2293 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ---NETC--EALKKVKDIQK 2347
                  L+    +S  V+  ++++  W   VE SL    Q   N T   + + K   +++
Sbjct: 1734 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 1793

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            ++  +QS+I++  E +         +   SL   M  L  +    S    +T A ++E  
Sbjct: 1794 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 1853

Query: 2408 EK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
             K    E++ E  + FL  K  A    D  G   V E   + +Q       + +  L+ +
Sbjct: 1854 TKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY-MQESTSEFLEHKKHLEVL 1911

Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
                + + +H      + + E+    +++F+       + K+A+  C  +L +F+   + 
Sbjct: 1912 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 1971

Query: 2527 LNLWIHEMEER-------FNTENLGESKQHIPE-------KKNEVHKVE---MFLGELLA 2569
            L  WI E  ++       F  E+LG+S +   +       K  E+ KV    + L  L++
Sbjct: 1972 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2031

Query: 2570 A----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-----------HQNLLRMTKE 2614
            A     +++  +   G +L+ EG     E    ++ LTS           +++L  + K+
Sbjct: 2032 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2091

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
            K+      L + +  +E   +M  W++ +       + T    DT   +    Q+     
Sbjct: 2092 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQN---KS 2148

Query: 2675 GEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLETLKEVWADIMSSSVHAQSTL 2728
             E E+K N+  + + +  L    +E     +       L  +   W ++   ++  Q  L
Sbjct: 2149 FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL 2208

Query: 2729 ESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDH 2786
            E   +    +   + QL+QW+   +  +    PL   P +         +Q +L E    
Sbjct: 2209 EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN--TQRQQVQILLQEFATR 2266

Query: 2787 TRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDIMT-VAKEKMRKVEEIVKDH 2842
                 +L A  + +  +  ED S +   +E+L   TQ  D +T    ++   +++ +   
Sbjct: 2267 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2326

Query: 2843 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---KIKELI--DSREIGASRL 2897
              Y   +   +D L     +L     +S    A  ++L    K+K+ I  + ++I  ++ 
Sbjct: 2327 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQ- 2385

Query: 2898 SRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2956
            +  E L+  VK+       E +  E+ + L    K ++D   + ++ +++L S  A S Q
Sbjct: 2386 ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQ 2438

Query: 2957 EFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLEGKNTDEEIVECWHKGQEIL 3006
                     +Q    F A L T  ++          L +LE    D +        Q  +
Sbjct: 2439 --------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2490

Query: 3007 DALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
                 AE     LK+Q +E       L+T         K+            + +E  L+
Sbjct: 2491 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV-----------KERENKLK 2539

Query: 3067 QRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNISEVST--SLQK-IQEFLSES 3114
            +   KA +  +Q      W+   +    +   C D  +  + ++   SLQK + +     
Sbjct: 2540 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2599

Query: 3115 ENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ 3174
            E   +  N +LS  E+   ++T E    IQ KV    E        LH K+  LEN+  +
Sbjct: 2600 ELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-------LHSKKFCLENMTQK 2651

Query: 3175 MKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNR 3232
             K+F EVS E  +      E++ +H+S   L       +    LQ+  + +   + Q++ 
Sbjct: 2652 FKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYLTMLQTQQKSLQALKHQVDL 2708

Query: 3233 LKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3289
             K  AQ L    + SK       +V  ++ ++  LS    EK S L+  +     F   I
Sbjct: 2709 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768

Query: 3290 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKLEALLSVKQEKEIQMKMIVT 3342
            +E+     +    LDS      D   L  +         KLEAL++         KM++ 
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 2828

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
              E     TSP+ +  I++ L+++      LL      + Q+EG + +   +   +++FS
Sbjct: 2829 TEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 2882

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSYSSLLETIEVKGAGM----- 3456
              +   E +         E       L   K+   EE+       + +   G G+     
Sbjct: 2883 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 2942

Query: 3457 --TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEK 3514
              T     + +L D+  R++ + ++  +   + ++ +     +Q  L++   W+   +E 
Sbjct: 2943 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3002

Query: 3515 LDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES 3574
            +        +    +  +++ + LQ    + ++ +  +    E +  +  P  + + L+ 
Sbjct: 3003 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQ 3062

Query: 3575 LR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNR 3631
            L      W+A  ++      Q   +    +   +  + ++EWL T E+++       +  
Sbjct: 3063 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3122

Query: 3632 ATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------DESHVNSRMG------CQA 3679
            +  E Q+ Q K   +++  +   + +  +  Q +       D+  V S++        + 
Sbjct: 3123 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3182

Query: 3680 TQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3738
             + +     LL Q L   K F E+E++ +           +W    H     ++  +   
Sbjct: 3183 QEKSHSRSELLQQALCNAKIFGEDEVELM-----------NWLNEVHDKLSKLS--VQDY 3229

Query: 3739 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3798
             T  + K+   L VL +D+      +  A   G   +K     E   ++ ++     + K
Sbjct: 3230 STEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3289

Query: 3799 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3858
            ++T        TLE+ L LA+      + L  W+ + +  L   E   ++  E      +
Sbjct: 3290 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3349

Query: 3859 YKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKIDQLQSDYQDLCSIGKEHVF 3915
             K L++   +++  + S+ E   ALLELV       L+  + +    Y+ +     + V 
Sbjct: 3350 PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVE 3409

Query: 3916 SLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAG 3975
             ++A +   + ++        W+ +   +L++   +     +T + QL   K    EI  
Sbjct: 3410 EIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3468

Query: 3976 FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHEL 4035
             +D +++L   G  ++  C++  +  +K+ +   L+    +Y  IC      Y  LE   
Sbjct: 3469 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----NYDTICQINSERYLQLERAQ 3524

Query: 4036 QKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS 4095
                   +T ++   WL+  Q  +   P P L       + +  R  QE+ R   +L+  
Sbjct: 3525 SLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EYETLRQQQEEHRQLRELIAE 3577

Query: 4096 MCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--- 4149
                 +   KT  + ++ +     +I++K V A  L   + +IK    +  + L +A   
Sbjct: 3578 HKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YSQIKEDVKKRAVALDEAISQ 3634

Query: 4150 --------DQQLQNMKRRHSEL--------ELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
                    DQ L++++R    L        E+   +  +S+ K+    ++  Q    T+ 
Sbjct: 3635 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 3694

Query: 4194 EKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCLQREE---DLQRTRDYHDCM 4246
            ++  ++  +    +     K +    DQ + +    + L  +RE    D+    +   C 
Sbjct: 3695 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 3754

Query: 4247 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ------ 4300
            ++  +   K T ++      D E   +    +K+   A +  +  I+ L+++        
Sbjct: 3755 HMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 3810

Query: 4301 -KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4359
             ++I      DK +VK+    L   W  L    K +I      ++     Q   Q + +W
Sbjct: 3811 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 3870

Query: 4360 AEEQQPNIA----------------EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4403
             +     +A                E LKQ       Q + M+ L   +EL     LLK 
Sbjct: 3871 VDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAEL-----LLKK 3925

Query: 4404 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4463
            + +++D+            +Q  L + +   + L + +  R+  L  AL    QF  A+ 
Sbjct: 3926 VTEESDK----------HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 3975

Query: 4464 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE 4523
            +  + +   E  +  ++ +   P  +  ++      Q  +  +Q+ V  +   G +L++ 
Sbjct: 3976 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4035

Query: 4524 VTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI 4583
               +E S +  KL+ L   + +VL+K   R Q+L+  L   K F  + +    WL   + 
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095

Query: 4584 VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSE 4643
                   L         QL  +  +       E    +L + GQ +L    +   + + +
Sbjct: 4096 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4155

Query: 4644 KLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD 4703
             +N L  ++  +     ++  K++EA+    E+ + ++     L++ E Q L ++  P+ 
Sbjct: 4156 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE-QTLNVASRPS- 4213

Query: 4704 LAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ----PDKMLHLVTLY 4759
            L ++  L   D  +   +EV    E + EL++     +   Q        + ++ + + +
Sbjct: 4214 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273

Query: 4760 HRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKSVKEEQSKVNE----ETLPA 4811
             ++ ++  +R   L+D    A Q HE   K+ + LE   KS+  E    N+    +T  A
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4333

Query: 4812 EEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELK 4866
            + K     L   HS+  +   +G  LK  T   +D           K    +   + +  
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---------KLDDMLSELRDKWD 4384

Query: 4867 LLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG--PVYLDLNLQDIQEEI 4924
             +     E   + E  ++ S  F   +   +DWL RV+ +L+   PV+ D++L  +   I
Sbjct: 4385 TICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDL--VMNLI 4442

Query: 4925 RKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4984
               +  Q+E+      + AL    +E    +++  S+ ++  + ELS     +     ++
Sbjct: 4443 DNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKVQMQELSTRWETVCALSISK 4501

Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL-KSHMEFFSTED 5043
            Q  L     Q + ++ V  A  +WL +A++ L+  G   D E A   L   H EF    +
Sbjct: 4502 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4561

Query: 5044 QFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQKVASLELRSQRMSRDSG-- 5090
            +  + L +  ++  T+  +  P             +   E+ +A  +   QR++      
Sbjct: 4562 EKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL 4621

Query: 5091 -AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLSE---FSLLKTSSSHEAEEK 5141
             A+ +LL+   A  QW +     K +E + + + + +  ++E   F    T    + ++ 
Sbjct: 4622 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681

Query: 5142 LSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGNDASKATLSRSMTTVWQRWT 5193
               +K   +  +S    I  L++         AS L  +G+     T +  +  +  +W 
Sbjct: 4682 TKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQ 4741

Query: 5194 RLRAVAQDQEKILEDAVD 5211
            ++  +A ++ + L DA+D
Sbjct: 4742 QVWLLALERRRKLNDALD 4759



 Score =  318 bits (815), Expect = 1e-85
 Identities = 900/4830 (18%), Positives = 1875/4830 (38%), Gaps = 684/4830 (14%)

Query: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
            V+    W+D M+  L+ +E   ++L    + L   K ++  +  + S L+  ++    MT
Sbjct: 282  VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340

Query: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
                  L+L   ++ +R   + AK   T   +   L  LH    R      +WL +++E+
Sbjct: 341  ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 395

Query: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
               Y   E + +       H   +R+L + + +    Q +   +L       P+ +    
Sbjct: 396  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 452

Query: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
             RA    +  W     Q  +  + E    F              ++  ++L+  ++ +  
Sbjct: 453  YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 504

Query: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
            +    R S+    E  + +  +  EE+  Y+  +  +  +A+ I+     NS    + + 
Sbjct: 505  KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 564

Query: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
              +    Y+ + + + +  + +        + ++ S   +E+ + S        +K   +
Sbjct: 565  PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 624

Query: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
            +A +I++       + + TL     + +K +   H L+      R     ++K +  GE 
Sbjct: 625  LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 679

Query: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
            ++    L+    D +E  +E       +   LEK +++ K++             YQE+L
Sbjct: 680  QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 726

Query: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
               E  + E       +S+ ++++  + + E   ++ +R      +  E++  + +   L
Sbjct: 727  KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 786

Query: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
            K ++++L+ D   + +  +E  FS  A         SEL  V + + Q   MS   +  D
Sbjct: 787  KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 843

Query: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
             L+T +L     Q A      +   + EE A   D+ NN++    TL  Q    +  K +
Sbjct: 844  KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 900

Query: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
            Q  HA L+       AI     + Y+  + +   H  + D L   + W +  VQ D    
Sbjct: 901  QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 955

Query: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
                L   E I K +K++R        ++             V+TT + IQ+ +    +T
Sbjct: 956  ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1000

Query: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
            +  +L Q + L     EI+  +S++    + A+Q    +K    EL+    + MV   + 
Sbjct: 1001 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1055

Query: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
               K +  Q+S + II++   L  +     +  +  L  Q++     S     + E+ L+
Sbjct: 1056 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1110

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
              +  H       V   K   +W     S+   T    E   K   + Q  K + E++  
Sbjct: 1111 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1157

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            +K+++ E L      L K      ++   +LE  +K       T  E  N++   F E +
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1207

Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
            +  +E Q +    +++    +  Q        IC  L   +     LI   +  M   G 
Sbjct: 1208 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1264

Query: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
             E +  Q                   +++ L K +    Q L  V + T    +   + +
Sbjct: 1265 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1306

Query: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
             +E   L+   +++    C+  Q +LK  Q++        +EL K VT     E EK   
Sbjct: 1307 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1356

Query: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
            + +L+E ++  +++L       K S R     K ++ +   HF+E        + D+   
Sbjct: 1357 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1416

Query: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
             L + D+         N + +     A+++ I+ Q        ++  + L++ GQ + P 
Sbjct: 1417 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1476

Query: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
              E     L + +  L   +   +A ++ K    + +QE +        E+   ++ + Q
Sbjct: 1477 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1532

Query: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
             L  LEA    ++ + T L       E+ +S +   R I      + EA    +++  G 
Sbjct: 1533 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1592

Query: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
              T    +    K+ H    +  L  +     + L+D    YQ +E     L   L++ +
Sbjct: 1593 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1652

Query: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
               SK   E +  + K     L+   +L G +    +    LK+    L D    L P A
Sbjct: 1653 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 1711

Query: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
                +  +    G  + L+ ++ E   + +  + +S+  Q  +   LDW+  V++ L   
Sbjct: 1712 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 1771

Query: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
              + LN   +Q+ I K  + ++++      +NA++ K K+         ++ L+  + +L
Sbjct: 1772 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 1831

Query: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
            S    +     +   A + E+ ++ + +  + +    +LE   Q L ++   G DV    
Sbjct: 1832 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 1889

Query: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              L  +M+  ++E   H  +LE LHSL+  +     P+ K  + +K  +L  + + M   
Sbjct: 1890 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 1947

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
               + + +  C  Q   +Q   + +   + +T KK+      F       S E  +KL E
Sbjct: 1948 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2007

Query: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
              +L                  +S V +  + I A++   + L  E T  +  +   ++ 
Sbjct: 2008 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2067

Query: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
            +T++ +  T +    +D   +L+D + E     +K++KA E    M+  LQ         
Sbjct: 2068 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2127

Query: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
             + P  +  +A K    T +E + +F  EL+Q  + +  L+ +   +L++   P   E P
Sbjct: 2128 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2181

Query: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
               Q +T +  +   + +      + +++   +    +T    +K W+ E +     LG 
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2241

Query: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
             +I+   ++ Q +++QILL E    +   E++    +    G+ +    + SL      Q
Sbjct: 2242 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2297

Query: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
            LA V      +  Q+ D+   ++Q+   S     Q Q L + L+  L+ L  K  + +  
Sbjct: 2298 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2353

Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
             T    + ++L+       E+    ++             L +   L   L++++  + +
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2413

Query: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
              +   ++AEN +  L  A +   ++ +M      W++  K         N +  +  + 
Sbjct: 2414 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2467

Query: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
             + ++L+++ K+    L A +   +   +    E  +  +   G E   L+  +     N
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2523

Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
                 K +K+ E +LK+   +LE+A           L  KEQ+   + L   ++  +  +
Sbjct: 2524 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2566

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
            + ++ C       E+ +A L        LQ+E    QH  + +       +++    +  
Sbjct: 2567 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2617

Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
            E    E K L Q ++    ++  K     N+       QE+  +  R  + A++     +
Sbjct: 2618 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 2677

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
             + S     K LTM       L  +     LA+              GT D+  ++    
Sbjct: 2678 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 2737

Query: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
              H ++      +C  L + +      + T  E+ S  A       S +PV     ++ +
Sbjct: 2738 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 2797

Query: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
                  A+ + L A     D A        + E   P L       L  L +    L + 
Sbjct: 2798 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 2856

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
               ++  +   ++R +++   L+  S     I L+ +E  E  + P   E++    Q  M
Sbjct: 2857 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 2911

Query: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
             ++   ++EI  LQ        L + L+  + ++   +   L+  L  +  R  T+  K 
Sbjct: 2912 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 2968

Query: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
            + +   L+E L   L   R + AL+        L SW++ T+  +     P  E   ++A
Sbjct: 2969 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3018

Query: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
            Q         L+D +   VE+                KV  L +LS+ +     L  KA 
Sbjct: 3019 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3078

Query: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
            T++         R+L+G  +  Q+  H+  + LN   T  EK   + +   TQ+  ++E 
Sbjct: 3079 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3128

Query: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
            +AQ +          +   K L Q ++  +SL + ++SR ++ ++Q           E  
Sbjct: 3129 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3183

Query: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
              +  + ++L Q L     K   ED++  M W   +H        Q++ST+    Q + L
Sbjct: 3184 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3241

Query: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
               QE +L  + N    LL+G+ L K      +   +   L+ +   +++++  S    +
Sbjct: 3242 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300

Query: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
               Q++ L ++L+       TWLD VE  L  +    L  EE        + L K+ K  
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3360

Query: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
               +D + N  S A  E        G  + V ED       R  L+   + Q+  ++   
Sbjct: 3361 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3414

Query: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
            + +                          +  F+Q    ++  I + E  L       +E
Sbjct: 3415 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3448

Query: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
              +   +LQV++    E+ + +D+ D+L+       +  ++    ++K + ++ L++   
Sbjct: 3449 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3508

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
            + +   E+            E  Q L+++  E ++ L     LTET  + IIS       
Sbjct: 3509 ICQINSERYL--------QLERAQSLVNQFWETYEELWPW--LTET--QSIIS------- 3549

Query: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
                +L A A             LEY  ET       QQE  RQL           L+ E
Sbjct: 3550 ----QLPAPA-------------LEY--ETL----RQQQEEHRQLRE---------LIAE 3577

Query: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
            ++  +             +N+  P+L + L  G+   I       ++  +Q+ E      
Sbjct: 3578 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3619

Query: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
              + K    L+  +   T++  +   ++  L+   +RL    +Q  ++  E+E +++ ++
Sbjct: 3620 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 3674

Query: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
                 S +++    L  ++   G +++       K +    ++ +L ++   W ++ T +
Sbjct: 3675 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 3734

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               + KL  L + +L  +      MS I  +++      D     I    + +  +  + 
Sbjct: 3735 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 3791

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
             + +I+  Q  +D V    + + S+ + +    DK    + +  +N +W  L     ++I
Sbjct: 3792 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 3847

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
              LE  +++  +Y++ +Q +  W +    +L     IG D  +V+  +++ +  +     
Sbjct: 3848 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 3907

Query: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
            ++ E+E++      L++   E+     V   L EL   W +L+  +   +  L+  L   
Sbjct: 3908 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 3967

Query: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
               + A D++ ++L      LS  + + G  +A+++++     LQ+D+   + +++    
Sbjct: 3968 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4027

Query: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
              N L++         L N L+ +N RW N+LE+  ++ Q     L+   + K +  +  
Sbjct: 4028 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4084

Query: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
               Q   D    LL +       + A +++   ++ C        T K     L + G+Q
Sbjct: 4085 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4140

Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  +   SA + I  D  +L +   ++E  L +++T L+  +     F  SL+    W+ 
Sbjct: 4141 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4200

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
            +AE+ L       S  L T+  +++E K    + +S    +  L++ G  L      +++
Sbjct: 4201 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4259

Query: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
              ++NL       W  +  +  ER   L     + + F E     ME+L ++E+ L   +
Sbjct: 4260 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4319

Query: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
            EI+ +   +  Q   H+ FQ  + ++  +  +    G+ L E+  + DD  + +  L+ L
Sbjct: 4320 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4379

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
             ++W  +  ++ +R+  ++  +    ++ +  + L  WL  V    ++    V   +   
Sbjct: 4380 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4438

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
              L D      K F ++ G    +V+A K+    L+       + ++ ++ E+  +W++ 
Sbjct: 4439 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4494

Query: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
                  ++ +L   L+  E+    +   LE L   ++ L     LPD  + L     + K
Sbjct: 4495 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4554

Query: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
            E    +     +L + + + DT+ A    D I+ +   + +++ ++EE+       +Q++
Sbjct: 4555 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4614

Query: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
               L       E  + L  WL   E+ ++     +I + IE++K      + + EE+   
Sbjct: 4615 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 4674

Query: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
            Q +  ++ +  +R A       SH                         ++IE K  +VN
Sbjct: 4675 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 4734

Query: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
                +WQ +  L   R +KL + L  +++L
Sbjct: 4735 LLVSKWQQVWLLALERRRKLNDALDRLEEL 4764



 Score =  298 bits (763), Expect = 2e-79
 Identities = 728/4019 (18%), Positives = 1555/4019 (38%), Gaps = 470/4019 (11%)

Query: 4948 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4998
            E+EK  K  E +  DL           S A  S     ++  L      + ++YS    Y
Sbjct: 782  EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841

Query: 4999 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 5043
                +  N  L++   A+ L++L    L  E A        ENL S ++ + +E      
Sbjct: 842  IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5097
             FH+  +EL    A  D + K   + DL+     +K   L  R Q +      ++  L+ 
Sbjct: 902  VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961

Query: 5098 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5155
              +    + D     ++ I+ +  T++K+ E    +  +S     +L++ K LVS +   
Sbjct: 962  IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1018

Query: 5156 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5213
              K+   ++ A Q   T  D    T++ R+M    Q+   + R +    + I+++ +D  
Sbjct: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1078

Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
            T +   V   T+ I    D L     E+ S  E     + H     EL++  S +     
Sbjct: 1079 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1131

Query: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5327
            +TL   +    P   ++    +EI+  +++     + +     K   K+  +E  + E  
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1191

Query: 5328 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5387
            V+T   S      E+ + L       D ++EE            + + +  +E KEK  G
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1239

Query: 5388 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5430
            +  +L          + +  + +  ++LK     Q+++++  Q  A         T   L
Sbjct: 1240 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1299

Query: 5431 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5485
                +KL+++   +    L + K K + + ++A+  +K L + +     +  E  AAV++
Sbjct: 1300 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1359

Query: 5486 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5539
              E   ++   L     + K +E     H+Q I Q      +     S + E +E+   +
Sbjct: 1360 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1418

Query: 5540 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5596
            L+     +V   GT   N   Q ++    H+ ++ + + +       + + EK     S 
Sbjct: 1419 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1475

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
               EK+ + + EL    E      + +++      ++++KF+A+  + +  L+Q++  L 
Sbjct: 1476 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1535

Query: 5657 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5705
            + E G          LK Q S  + ++S    L+       + ++  +S  +     V +
Sbjct: 1536 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1595

Query: 5706 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5761
                    R  + A+    +   +CN++    +  V +Y+ YE     L           
Sbjct: 1596 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1644

Query: 5762 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5819
                   + +Q  +A  S+H  E +A   K  Q Q+    +      ++ + ++  + V 
Sbjct: 1645 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 1692

Query: 5820 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5867
            +++  AE   D  G LLP  +     +    GR   L   V E             S ++
Sbjct: 1693 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 1752

Query: 5868 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5919
            G         N E S     + P         ++++I   Q ++  +   +A  ++    
Sbjct: 1753 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 1810

Query: 5920 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5979
               E  +P    S  AK+ DL   +    +   E    + E   + + +++  + + T +
Sbjct: 1811 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 1870

Query: 5980 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 6039
            E     L+E   PG+         Q    E L  +  + E+  SL +E+ S    +D A 
Sbjct: 1871 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 1929

Query: 6040 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6089
             L   + L+   + M  TI+ K              Q+L + L   ++E  ++  + +  
Sbjct: 1930 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 1989

Query: 6090 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6149
              A++L   L  TK   +       E   +    +   N++  +     A++  +V +  
Sbjct: 1990 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2047

Query: 6150 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6206
             +L G+    +  E  A K L  +K  + ++     D  L ++    E     S +    
Sbjct: 2048 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2107

Query: 6207 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6255
             +S  + +WL +   T T+ +Q+            ++Q K  E EL +  + ++ +  + 
Sbjct: 2108 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2167

Query: 6256 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6299
             E+L      E + D  E P         D   QEL         + E+SS         
Sbjct: 2168 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2221

Query: 6300 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6337
            E+  +++  +++L+ +VL            +++Q Q+L          Y +      G+ 
Sbjct: 2222 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2281

Query: 6338 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6394
               G+ P+  +  V   L  + Q ++ ++ Q         Q+I    +    + + S  L
Sbjct: 2282 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2340

Query: 6395 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6454
             D++ +L  + A+    T     NQ++      +   + +K +   +QA  E+     V 
Sbjct: 2341 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2396

Query: 6455 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
            E+ L   L R    +L S   V Q+     + LQ      +  + +        ++  +K
Sbjct: 2397 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2454

Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6558
                   P++ +++ ++      K+F   +       +K   E  ++             
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2514

Query: 6559 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6617
             +L+ ++  +D     +  R + L ++L    +Y+  ++ L   ++  Q  +   +  + 
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2574

Query: 6618 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6673
             ++ E  I +L    KE  Q      +L  T    +    + KE  T  +  L+ +   V
Sbjct: 2575 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2634

Query: 6674 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6730
             ++ H +   LE + + +    E  +E  RQL+  +  +    S+G    +   L    T
Sbjct: 2635 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 2690

Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6786
            + Q  + SL   + ++       + L++  S     SD+  Q+  + +   + + ++ ++
Sbjct: 2691 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 2750

Query: 6787 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6846
               LET L+    +Q+   ++        D L+        V ++ E ++        F 
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 2806

Query: 6847 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
            K+++A  +   +   T   +L  ++   D   ++ +L  +  Q   LL    A +E++  
Sbjct: 2807 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 2866

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6960
              + +L   +  S++  +  L++   + +E      +  + I++ L  +K F+ +    +
Sbjct: 2867 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 2923

Query: 6961 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 7020
              KQ  V+++ Q ++Q +++   ++  +       L  +N  W+ L   V ++   L+  
Sbjct: 2924 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 2978

Query: 7021 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
            L     +++ ++ L +W  +T+E    Q+    +   V+  +++ + L+ L+  ++  VE
Sbjct: 2979 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3038

Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
             I++ G  +    +      ++  L  L   W  L +        L+ +           
Sbjct: 3039 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3098

Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7199
            + +N +L      L     +      ++ Q+   + L+DD+    + L +  SI  Q LK
Sbjct: 3099 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3157

Query: 7200 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7245
                   + +  +  + +  W     EI E+  S   LLQ                  + 
Sbjct: 3158 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3214

Query: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7300
            +      S +  Q+  T  L K  +   +  +++    Q+ +  LL GL  +K    D +
Sbjct: 3215 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3274

Query: 7301 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7354
              + +  E +K +      +    A  ++   L L++ L +  + LC     ++  +L Y
Sbjct: 3275 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3333

Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
            ET                ++L+G++ S +      Q R +ELK +     ++   LD LN
Sbjct: 3334 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3368

Query: 7415 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7468
            E+   L    P   +E   K +   N  + L+S   T++  ++ + +L+ Q F +  +  
Sbjct: 3369 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3428

Query: 7469 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7526
            + ++ +TE+KL    +I         Q +  + F  E+   + I+  ++  G +++    
Sbjct: 3429 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3488

Query: 7527 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
             +++     KL  +   +  + +   +R   ++       ++ E  E+L  WL E   + 
Sbjct: 3489 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3547

Query: 7587 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
               +  +P P  +  TL  + +   ++   + +   +I  +      LL    G      
Sbjct: 3548 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3598

Query: 7645 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7701
             E   IQEK+ +A     +++E  KK A  L +         D ++++    +++ + L 
Sbjct: 3599 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3657

Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7750
                 + AE  + KE  +   + + D+ +L  L +TL        A     D  I    +
Sbjct: 3658 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 3716

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7810
             ++++ +   WE +   +  R  ++ + +     F   +  L   +   +  +    D  
Sbjct: 3717 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 3776

Query: 7811 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
            I+  + K +++     +EEI   QE    +  +G  L  A  E     ++  + ++N  W
Sbjct: 3777 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 3836

Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7924
              L      R+ KL+E + A  Q    + ++  W+     +LA   PI  D    E +++
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 3893

Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
            ++ E ++ + +  +    +  + +  E+LL        +++  ++Q     L   W ++ 
Sbjct: 3894 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 3950

Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
               + R+ K+E       +F         WL  +E   +     G      + EL K   
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4010

Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
             Q  V    + +E +NK    L   +  + A +L+  +   NQRW N+ ++     ++L 
Sbjct: 4011 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4070

Query: 8105 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8164
              + Q + F    + +  WLT+ +  L   +        AK +QL    +  +    K E
Sbjct: 4071 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4129

Query: 8165 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8221
                ++ +G+Q++ +        I+++++ L+   + V                   E  
Sbjct: 4130 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4170

Query: 8222 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8280
            L++R+ +LE++  L+ + +H+   D +    Q    L+++    L            +D+
Sbjct: 4171 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4218

Query: 8281 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD-----HSALESQI 8335
            +  + D     + ++ S   + +   D+ G   K F  +  V L  +      S  E  +
Sbjct: 4219 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4277

Query: 8336 RQL---GKALDDSRFQIQQ--------TENIIRSKTPTGPELDTS------------YKG 8372
            ++L   G++LDD+R + +Q         E +  S+     EL+ +            +K 
Sbjct: 4278 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4337

Query: 8373 YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 8432
            + K LG   S  D+  R    LKE+       + L   +   + + D+W+ +  +++ ++
Sbjct: 4338 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVERQ 4394

Query: 8433 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8492
             ++++ L    QF   L ++  WL   E +L + Q +    DI  +   I   K  QK +
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKEL 4452

Query: 8493 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
              R + + ++   + E  +    +S  ++ ++ +++ RW+ VC+L    +  L+ AL Q 
Sbjct: 4453 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4512

Query: 8553 QGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
            + FH + H LL  L   ++  R + ++P D +     L D HK+ M+   +L E +  + 
Sbjct: 4513 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELN 4568

Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
                M   +L           K  + +I  R + +L    +H + L   L    ++Q+L
Sbjct: 4569 KATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4627



 Score =  290 bits (741), Expect = 6e-77
 Identities = 817/4617 (17%), Positives = 1774/4617 (38%), Gaps = 529/4617 (11%)

Query: 1370 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1427
            S L S+ S LE  K   +  E      E+ +KEA  SEI +    K    ++   ++ Q 
Sbjct: 303  SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 358

Query: 1428 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1487
             KL +T     + ++ +     +F S      +W+ EKE+E  A + S    +  I++ K
Sbjct: 359  AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 412

Query: 1488 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1541
                  ++E++ K  +I  ++E A+   Q +     AR  I+A    ++     + +  Q
Sbjct: 413  DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 469

Query: 1542 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1596
            C+E     H+ +   + E     +++     + K A+  K  C  ++  +K+   +QE M
Sbjct: 470  CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 525

Query: 1597 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1646
            +  + L    S I      A+ ++     N D  ++ +  ++     +Q E  + +  E 
Sbjct: 526  EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1705
              A  +  A W+ +    +  +           + E    A+R+  E + Q +  L +E 
Sbjct: 586  VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 643

Query: 1706 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1754
                  VVS     +++ +++ S  +VAS   +K M     +  L  L  R+ D  +   
Sbjct: 644  HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 695

Query: 1755 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1814
               +  +S V       +L    +V  K +  EL  ++E    +  V    +  + +EV 
Sbjct: 696  ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 747

Query: 1815 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1873
            + +  L++ +  L + + +    +DLH    +  +  +L +E  ++ +      +   EF
Sbjct: 748  NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 807

Query: 1874 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
                A+ S +      L  + Q +    SM+    D + K +N  L+N +A E A V L 
Sbjct: 808  FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 864

Query: 1928 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1984
                   Y  K+   E           +  +   I+NL+ T +   SE D    +  A +
Sbjct: 865  -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907

Query: 1985 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2038
            D+ ++  K+I D   +T KER       KE   Q +++   V  Q+++ L         L
Sbjct: 908  DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 959

Query: 2039 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2094
            +   K +      + P +D  I ++E T    +R I ENQ +    +      Q +    
Sbjct: 960  EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1014

Query: 2095 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
             +   SK+ E          T+KD E     +     ++ K   K++ +    S    ++
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1071

Query: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
             E   + +   +LV T M   +    D  ++LEE    L        + +    E++ W 
Sbjct: 1072 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1127

Query: 2214 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2260
            +N              P   + IS+ +   + E+L +  ++     A   +++  +  N+
Sbjct: 1128 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1187

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
            L++  K L+   +L F E+  +++L+ ++   +V K   K    +  + ++ +  I    
Sbjct: 1188 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1244

Query: 2321 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
            T+ E  L+   +     +    LKK +  Q+ELQ      +     +      +     E
Sbjct: 1245 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1304

Query: 2377 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2430
             L +    LI  K +EA     QL  K + S +E L+K  + +++E  E     K   + 
Sbjct: 1305 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1363

Query: 2431 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2457
                           + S+R G    +V+E      Q                N+L++  
Sbjct: 1364 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1423

Query: 2458 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2487
            DGQ                       S+  AV   TQ  Q L      +LS +    +Q+
Sbjct: 1424 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1483

Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
             + +    ++  L +  K  +       EL  F+  + +   W+ + E+    ENL    
Sbjct: 1484 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1541

Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2605
              I     ++ + + F         S D +S +G L  ++  G+   +  + CS+     
Sbjct: 1542 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1592

Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2661
             +     +E  R    A     +L      +   +K + D+    E      L      E
Sbjct: 1593 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1652

Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
               S+     +      ++  +   K  Q   SS +     ++   E L +    ++ + 
Sbjct: 1653 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 1712

Query: 2722 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
               Q TL+ ++ ++ D  +  N+     E +   +   L  Q GL E    + +++S L 
Sbjct: 1713 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 1769

Query: 2782 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2818
            E      ++ AL  +I+K+  L                    + +T D S   + Q ++K
Sbjct: 1770 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 1829

Query: 2819 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2874
                +F++     KE + K+EE+     ++ +   +   +L +  + L        D + 
Sbjct: 1830 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 1889

Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
             +Q       E ++ ++     L  + SL  E+  +   S   L+  +   L   +K+ E
Sbjct: 1890 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 1945

Query: 2935 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2973
            D++ + +    SC E L                   ++ + +  F  +   L ++LE   
Sbjct: 1946 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2003

Query: 2974 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             L + W+ +                L+    T  + +     G  +L+  +     TE+ 
Sbjct: 2004 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2062

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
             +    L    +D++  S     L      L L+      N +    Q+ ++      QW
Sbjct: 2063 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2116

Query: 3080 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3136
            L  +N   T  +    P +   V T +++ + F +E +   +K+  +  K  ELL     
Sbjct: 2117 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2176

Query: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
              +A   +  +T     W+  +     ++  LE     +  F+     ++ WL + E MV
Sbjct: 2177 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2236

Query: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3252
                    D      ++Q++Q +L+E    +PQ  +L    Q +        S R     
Sbjct: 2237 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2296

Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
            +++ ++ ++ +L+    ++   +D+ + +  Q+   ++ L D ++D  + L S    ++ 
Sbjct: 2297 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2356

Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3371
               ++ +    + +    Q+++ Q+K+     E +      E +   + +QL+ +   + 
Sbjct: 2357 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2416

Query: 3372 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3431
             +          L+ A +    +Q   R F  W+D+ +   N+S    A+L    +++  
Sbjct: 2417 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2476

Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3485
             K  ++ + + S + E    +G  +      +E    QL+L  ++  +    ++ KE   
Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2536

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEG 3545
            K ++ +    +Y+  ++    W+ + Q  L++       A   E ++  L+ LQ    + 
Sbjct: 2537 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQH 2595

Query: 3546 QALLNSVLHTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLR 3601
              ++  + +T   ++   + + +   +    +SL Q       +L   +    N+  K +
Sbjct: 2596 FGMVELLNNTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2653

Query: 3602 LMEQKFQQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEE 3657
              ++  ++    L+ A+E++    S  ++  SN+    +Q  Q     + + A + +V+ 
Sbjct: 2654 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDL 2708

Query: 3658 VGARAQEILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
                AQ+++ E   S   S +  Q   +   +  L  QV E+  FLE ++Q +   ++++
Sbjct: 2709 AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI 2768

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3774
                  +        ++A      +T+   K+ +T++  LK +E     L ++ +   + 
Sbjct: 2769 REMFSQFAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKT 2822

Query: 3775 VKYLEEGEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
             K +   E        +++++    +Q  +L    +     +E  +   +EF  K K  +
Sbjct: 2823 CKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFS 2882

Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQ 3888
              + + +E         ME      QL+ +K  Q+  +   +   + V   G+ L++   
Sbjct: 2883 ILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAA 2942

Query: 3889 DVT----LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGR 3944
              T    L+  +D + + ++ L     +    L+  +     +   L+ +  W++     
Sbjct: 2943 KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-E 3001

Query: 3945 LVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ 4004
            LVA     ++  + +  Q+   K +   +   +  +  ++ +G+ +    A   +   K 
Sbjct: 3002 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKV 3057

Query: 4005 NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 4064
             +   L      + A+ + A+   + LE          +TL+    WL+ ++  L     
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117

Query: 4065 PPLSRAEAIKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNA 4102
                 ++  +Q+   +AL++                       +R   D++ S  D S  
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQV 3177

Query: 4103 SVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRR 4159
                  +      + ++Q L  A+   +   E+ +  +E+   L      D   + + ++
Sbjct: 3178 WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ 3237

Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
             SEL        V Q    ++K    QA +N + E + + T  E      ++  +  ++ 
Sbjct: 3238 QSELR-------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYK 3289

Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVH 4274
            D+ + S ++    E+ LQ  R  H      C  + +V +E  + E   L   +A    + 
Sbjct: 3290 DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR 3349

Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
             + LKK A   +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +
Sbjct: 3350 PKELKKEA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3406

Query: 4335 KIQ-VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4393
            K++ +    L      Q+   EL  W  E +  +          D     L        E
Sbjct: 3407 KVEEIDAAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3465

Query: 4394 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4453
            +   + ++  L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S
Sbjct: 3466 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3525

Query: 4454 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4513
               QF     +    + + +  I       L  + + +Q +  +  +  +  ++  +  +
Sbjct: 3526 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3585

Query: 4514 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4573
               G +L+ E++  E   +  K     ++Y  + +    R   L++ +     F +  D+
Sbjct: 3586 NKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3644

Query: 4574 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
                L++         ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++   
Sbjct: 3645 ILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 3704

Query: 4634 NEVDHSY----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLS 4688
               D       + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ 
Sbjct: 3705 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIK 3763

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPW 4747
            + +  F+R  + P  +        Q+    I +E+ GL E +D  +N   E   + G+P 
Sbjct: 3764 DTQ-DFIRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD 3821

Query: 4748 QP---DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4804
            +P     +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + +
Sbjct: 3822 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 3881

Query: 4805 NE-----ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQI 4858
            +      ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +
Sbjct: 3882 SPIGTDLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTV 3935

Query: 4859 QSWQGELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLD 4914
            Q    ELKL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    + 
Sbjct: 3936 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 3995

Query: 4915 LNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD 4974
             + + I+ E+ K  + Q +V +    + A++    +    +    +++L++ L  L++  
Sbjct: 3996 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4055

Query: 4975 GDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENL 5032
             ++ E    R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L
Sbjct: 4056 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQL 4114

Query: 5033 KSHME----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
              HME    F + E+ + S +++   ++A        + + +++Q + +L+ + + +   
Sbjct: 4115 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETK 4170

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEH 5145
               +   L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EH
Sbjct: 4171 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEH 4226

Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
            K   + VNS  E+I+ L++  + L+          +   + +V  RW ++     ++ + 
Sbjct: 4227 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4286

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            L+DA      F+    K  E +++ +  L           ++ T L  H  F   L  + 
Sbjct: 4287 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4346

Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKD 5324
            S      +   S+          E+  L  +   + D    +++K  T  GK V+++ K 
Sbjct: 4347 SVYDTTNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKL 4397

Query: 5325 REMV------ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKM 5377
             E +         + ++  W+     Y   P +  D  +  ++ +++    NH+      
Sbjct: 4398 EEALLFSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK------ 4446

Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
                 +K LG  T      S+Q    AL    R+ I+    +    K   QELS + + +
Sbjct: 4447 ---AFQKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4494

Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
                 +  T+L+A                EE       L+E  A  ++ L  +G L    
Sbjct: 4495 CALSISKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD- 4542

Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHG 5552
               +  L + H++ +++ E + ++LN+A +  +      + + +  I  WI   +     
Sbjct: 4543 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4602

Query: 5553 TIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRE 5612
             +AW    Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E
Sbjct: 4603 VLAWAKQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---E 4653

Query: 5613 TEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
             EE++ +I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 4654 IEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 4710



 Score =  235 bits (599), Expect = 2e-60
 Identities = 796/4534 (17%), Positives = 1666/4534 (36%), Gaps = 676/4534 (14%)

Query: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 265  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 320

Query: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 321  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 366

Query: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 367  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 421

Query: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 422  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 472

Query: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 473  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531

Query: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 532  LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 591

Query: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 592  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 650

Query: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 651  VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 704

Query: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 705  GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 757

Query: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 816

Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 817  VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 871

Query: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 927

Query: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 928  DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987

Query: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 988  RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1045

Query: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 1046 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1091

Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 1092 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1132

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 1133 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1186

Query: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246

Query: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1306

Query: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 1307 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1361

Query: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 1362 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1421

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 1422 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1478

Query: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 1479 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1538

Query: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 1539 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1598

Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 1599 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1658

Query: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
              +      +  D    +  L + + LQ   +  Q  +  +  T E   D   S +P   
Sbjct: 1659 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 1713

Query: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
            D  + L+ +   ++     ++E   +    + +   ++    ++ +W+   E  +  + +
Sbjct: 1714 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 1773

Query: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
               N    +  + +     +++   +  +  +  + ++ ++ +  ++    QA    L++
Sbjct: 1774 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 1833

Query: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
            R+        + L +++ L+ +++  E     L ++ +               + ++   
Sbjct: 1834 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 1893

Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
            M     + LE   K +E  HSLLK     G  + K L   +   L K       + KE+ 
Sbjct: 1894 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 1945

Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
             T++++   +         F    K+L  WI E  + + +  +P     +    L   K 
Sbjct: 1946 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2004

Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
            LQ+      P ++ V   G +L  L+  VT                              
Sbjct: 2005 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2064

Query: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
                  +K  +  +   Y+DL  + K+ +  L  K+   +    E   + +WL +M+   
Sbjct: 2065 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2124

Query: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
                  P   +T +++T  +Q                                      K
Sbjct: 2125 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2184

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
             M+ EI      LN L +     + + +++L      +A+LKQ      +   + G    
Sbjct: 2185 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2244

Query: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
               + +T ++  Q L   LQ+  +R+   +Q  A   A Q  L    + P  R    +Q+
Sbjct: 2245 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2298

Query: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
                A+ ++  +    L   CD +  A VK+T    Q   +++  KL    N       +
Sbjct: 2299 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2353

Query: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
                  +   L+ A +  Q +++   +++  +AQ +   +   VK+ +  +A ++  +E 
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2410

Query: 4196 VNKLTKKEESPEHKEINHLN----------------DQWLDLCRQSNN------------ 4227
            + K  K  E      + HL                   WLD  ++  N            
Sbjct: 2411 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL 2470

Query: 4228 -LCLQREEDLQRTRDYHDCM--------------------NVVEVFLEKFTTEWDNLARS 4266
               ++  +D  +T      M                      +++ L    T WD   + 
Sbjct: 2471 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2530

Query: 4267 DAESTAVHLEALKK--------------------------LALALQERKYAIEDLKDQKQ 4300
              E      E+L+K                            L   E + +I  LK  ++
Sbjct: 2531 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK 2590

Query: 4301 KMIEHLNLDDK------------ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4348
            +M +H  + +             E+ KE  +   +   Q  D++  ++      LE +  
Sbjct: 2591 EMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT- 2649

Query: 4349 VQSRFQELMEWAEEQQPNIAEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIK 4406
               +F+E  E ++E +  +  A +Q    D   +Q     +L +    +     LK  + 
Sbjct: 2650 --QKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVD 2707

Query: 4407 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4466
             A R+  DL      V++ + S   S V    + + Q    L++ + EK  FL    Q  
Sbjct: 2708 LAKRLAQDL------VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 2761

Query: 4467 SQIQQHERKI--MFREHICLLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMK 4522
               Q   R++   F E    L     V +  +T +  + ++K +  ++  L A      K
Sbjct: 2762 GHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANK 2821

Query: 4523 E-----VTEQEKSEVLG---KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4574
                   TE+   +++G    L+ L    + +L +   R +++E  +   + F     + 
Sbjct: 2822 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 2881

Query: 4575 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILP 4631
               L++A+     +  +  E+  ++ QL  ++  + Q  E E L    Q     GQ ++ 
Sbjct: 2882 SILLQKAEEHEESQGPVGMETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQ 2939

Query: 4632 S-LNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4690
            S         L   L+ +  ++  +      +  ++QEA+L    +   +E     + + 
Sbjct: 2940 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 2999

Query: 4691 EAQFLRMSKVPTDLAVEEA-LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQP 4749
            E           +  V +A +  Q   + +LD+       V+ + ++ E   +T +P   
Sbjct: 3000 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADK 3056

Query: 4750 DKMLHLVTL----YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4805
             K+L  ++L    +  L  + E R   LE  +   Q+  +  + L   L ++  E+  VN
Sbjct: 3057 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVN 3114

Query: 4806 EETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS---- 4860
             E +  +  KL+   +   +L+D  I   +       +   L  L+  + +  +QS    
Sbjct: 3115 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3174

Query: 4861 ---WQGELKLLTSAIGETVTE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL 4915
               W  E++  + +  E + +  C +++     F  +    ++WL  V  +LS     D 
Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDY 3229

Query: 4916 NLQDIQEEIRKIQIHQEEVQSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELS 4971
            + + + ++  ++++ QE++   LR  N     L+  E  K T   E++   ++  L  + 
Sbjct: 3230 STEGLWKQQSELRVLQEDI--LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIK 3285

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEE 5030
                DI +       TL +     +R +   +    WL+  + ELL      L  E A +
Sbjct: 3286 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3345

Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSG 5090
                  E         + L+ L+ + + L  L+    +E LE+ VA    R + +S    
Sbjct: 3346 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3405

Query: 5091 AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVS 5150
             +V+ +     +   + +A +  +  + +TEKKL     ++     +   +L   K    
Sbjct: 3406 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTM 3464

Query: 5151 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5210
             +    + I  L +   ++    ++  K ++ + +  V + +  +  +  ++   LE A 
Sbjct: 3465 EILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3524

Query: 5211 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5270
                 F    ++    + + Q  +    A       L    E H      + + +  +  
Sbjct: 3525 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3584

Query: 5271 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5330
            + +    +L+     +PGE   + ++  A       ++E VK     + + +        
Sbjct: 3585 MNKTGPQLLE----LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3640

Query: 5331 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEK 5384
            +I+ +   ++   E L  P   I A++E+++  ++E  N   ++EK+       +++ E+
Sbjct: 3641 KIDQILESLERIVERLRQPP-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEE 3699

Query: 5385 YLGLYTILPSELSLQLAEVALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
             +        ++S +  +  LD  + I + I   ++E E       EL+   +K   D  
Sbjct: 3700 MIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHM 3756

Query: 5443 TILTKLKAKTD-------------NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ 5489
            +++  +K   D              V Q +   + + EE+DG   +L  +     + +  
Sbjct: 3757 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 3816

Query: 5490 NGQLGKPLAKK-IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 5548
             G+  KP+ KK I +L        +  ++R+ KL +A     +Y + L+ +  W++    
Sbjct: 3817 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD---- 3872

Query: 5549 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
            +A G +A  S S +       +  +EE K+  S  EA  ++++        E+++ Q   
Sbjct: 3873 IAGGKLA--SMSPIGTDLETVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAEL 3921

Query: 5609 LGRETEELRQMIKIRLQNLQDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLS 5664
            L ++  E     +     +QD   ++K      E  +   Q  LE A   L   +     
Sbjct: 3922 LLKKVTE-----ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 3976

Query: 5665 LKEQLSHRQHLLSEMESL--KPKVQAVQLCQSALRIPEDVVASLPLCHAALR-------- 5714
            L   L+H + LLSE + +   PK   ++L +  + +  DV+A      A  +        
Sbjct: 3977 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIES 4035

Query: 5715 -LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------- 5763
               EEAS LQ+         Q  + + EQ +Q++    +  +G H EIED          
Sbjct: 4036 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095

Query: 5764 -----KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5818
                 KP+     +  + Q++ H E+    +  +E   SL  K + +  +   +      
Sbjct: 4096 HLLASKPLG-GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4154

Query: 5819 TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA 5878
             ++  L E  E ++ +L    +     + +     ++L   +   +  E T +  S    
Sbjct: 4155 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS---- 4210

Query: 5879 CRSPSPVANTDA-SVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 5937
               PS + +T    +++   +   +++ R Q    ++  + +  + F +          L
Sbjct: 4211 --RPSLILDTVLFQIDEHKVFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLL 4266

Query: 5938 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5997
              +Q  WE +   + E+ R+L +A +R +++ ++   +   +E  E  L    E    P+
Sbjct: 4267 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPD 4326

Query: 5998 ---SQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
               +Q+A+H+    + L  +  + +  +     L  ++  AD  + L L   L+ L ++ 
Sbjct: 4327 KIKTQLAQHKE-FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKW 4383

Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
             TI  K+  ++  LEE L   L   +   ALQ        L  WL   +  L     P  
Sbjct: 4384 DTICGKSVERQNKLEEAL---LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVH 4432

Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
              +D+   L+D      +   K  +  +    +   L+EG   ++D++  +  +++ L  
Sbjct: 4433 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELST 4489

Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQ 6225
                +      KQ  ++   ++ EE    + A     + EWLA+A  T            
Sbjct: 4490 RWETVCALSISKQTRLEAALRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDED 4544

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
              ++ + Q KE  ++L E+++ L    + G+ +L
Sbjct: 4545 ALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4578



 Score =  224 bits (570), Expect = 4e-57
 Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)

Query: 500  LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 551
            L+K +  EL  +L  L    E  S +  W+ K  +  +  Q        +   + +E +K
Sbjct: 2088 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2147

Query: 552  FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
             FE    Q     Q LK      ++ +    EA    + + E  ++W+ L+      +  
Sbjct: 2148 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2207

Query: 608  LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 654
            LEE  +N  ++    A L+ WL + E              MLN      +   +      
Sbjct: 2208 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2267

Query: 655  QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 711
             Q+  +  AG  ++     D  +   +K+QL  +  +W  L  ++       D+      
Sbjct: 2268 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2327

Query: 712  EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 761
            +Y   + +LS   ++   KLS  L VS     MN +L     + Q+++  ++++ V  A 
Sbjct: 2328 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2387

Query: 762  --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 814
                  + K  +L  + S Q EG  K       K +  +  ++  C S   ++  S+   
Sbjct: 2388 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2447

Query: 815  IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 871
              L+  +++    +    K++ + +++ + +  S  L  Q H  ++ +A  EN    L L
Sbjct: 2448 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2503

Query: 872  IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 931
              +GS+     + L+ +  ++D     +Q+ +     +  ++K   +K+ VET    + K
Sbjct: 2504 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2561

Query: 932  FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 989
             + +  E++  L  A EG       + L +   + F  ++      N+ L  C+   +++
Sbjct: 2562 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2620

Query: 990  PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1046
             ++ +  +Q+      +LH +   L+          ++  E  R L   +E   +LD   
Sbjct: 2621 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 2677

Query: 1047 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1106
             L  Q  S K +    +  + +      + ++ L + L   L V     D+ GT  V L+
Sbjct: 2678 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 2732

Query: 1107 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1164
             E  A   ST  + +++   + +   +    F + I    +Q      E    A  G   
Sbjct: 2733 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 2792

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
              ++       K+ ET+     +L+ L  ++S + A K    +     +   LV +  ++
Sbjct: 2793 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 2843

Query: 1225 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1265
            E   K  +   D  Q +E      +K  LEE  S  KE            + Q    ++T
Sbjct: 2844 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 2902

Query: 1266 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1321
            E + +   +  +  +++ + +  K++DV    Q + Q+           H +L  + +  
Sbjct: 2903 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 2961

Query: 1322 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1379
              L +   ++  ++Q  L    RF+   E+++ ++  T    ++++  S +  + + +++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3020

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1437
            ++ K   +  +      E + +E  +I     P +K  + +Q   +  + + L +  E  
Sbjct: 3021 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3080

Query: 1438 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1494
             + +E +      F    E L+ W+T  EK L     + T +S ++ QI+Q K    +I 
Sbjct: 3081 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3140

Query: 1495 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1554
            +    +       QS     +  +   +++KL   + +  E++E +      +   L   
Sbjct: 3141 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3200

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1607
            + F E+  ++   ++E  DKL+  + +   +TE         +VLQE  D+    +++  
Sbjct: 3201 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3257

Query: 1608 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1665
            A+       ++    +  +   +  A++ +Y+DI + + +    LE  L   +RL     
Sbjct: 3258 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3317

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
               TWL++ E +  S E  +       + +++  + L+ E  +  +    L ++  +L  
Sbjct: 3318 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3376

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1785
            +      + ++  + + +ER+R +   I +++  + + +   QQFD+   +   WI    
Sbjct: 3377 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3436

Query: 1786 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
             +L +  +I +   Q +  L   K    E+   K  +  L     K+ +    E+   ++
Sbjct: 3437 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3496

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
             K +   + ++   Q+   R L L    S + +F +++  L   L +  Q++ +      
Sbjct: 3497 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3555

Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1957
             E + + +   +  Q  + +      +D +       L++   E          AD L  
Sbjct: 3556 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3615

Query: 1958 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2017
            +++           EA + +     F D+ +++L+S+E I ER  +        + ++++
Sbjct: 3616 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3672

Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2071
            +     +  ++   +     LK + +++        KD++ A  V  +++++   W++  
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 3731

Query: 2072 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2121
             L+ E + +   +++L  ++           ++ S ++  + T   I+D ED       +
Sbjct: 3732 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 3782

Query: 2122 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2177
            K      ET + +++  Q++LD   + G  L++      K I       + +  +S    
Sbjct: 3783 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 3842

Query: 2178 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2237
            W D  +KLEE M   + ++   D + +  D ++  +   +  M+   ++L+   +  E L
Sbjct: 3843 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 3898

Query: 2238 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2294
            K+F+SE   + + +E L+   +  + L K +    D   ++  LM+ KL  +  +E    
Sbjct: 3899 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955

Query: 2295 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2349
             +  L+       Q +  ++++  W T  E  L          +  E  L K   +Q ++
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015

Query: 2350 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2408
             + QS + +  +  N L       E  +L   +  L ++ + V +   + +  L  +L  
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075

Query: 2409 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
             K F   +++ Q+W    +     S    G  +  + +L+    +  +    +    ++ 
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4135

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            Q+GQ + A   K   ++I + I    E++++   +  + K  L++  +    F +  +  
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4195

Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
              W+ + E+  N  +           + + HKV  F  E+ + RE + +L + G  L  +
Sbjct: 4196 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4251

Query: 2588 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2643
                 Q+  L   LL S Q+    +++   E+ RS   A +  +   EA   +  W++  
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4311

Query: 2644 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2702
            +  L          D ++ +L+Q ++     G      +     G     ++S  +    
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371

Query: 2703 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2762
            +   L  L++ W  I   SV  Q+ LE  +     + +    L  W+  V+ ++      
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431

Query: 2763 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2821
               +     L+D+ ++   E    T ++  L   +REL E   +D S+     +EL T++
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4491

Query: 2822 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
              +  ++  K  ++E  ++    +   VH   +WL  A++ L     +  D  A +  + 
Sbjct: 4492 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4551

Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
            + KE +   E   + L++  ++   V           +   +  +RA   ++E+ +   +
Sbjct: 4552 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4608

Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
               + L S +A       G +A+ ++ LE   A L+ WA+  T L  K  D+E++     
Sbjct: 4609 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 4651

Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
             QEI           E++K+ + E   F  +++     V  + K Y
Sbjct: 4652 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 4685



 Score =  162 bits (411), Expect = 1e-38
 Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)

Query: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 683  LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 740

Query: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 741  LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 800

Query: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 801  TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 896

Query: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956

Query: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1016

Query: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076

Query: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1136

Query: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 1137 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196

Query: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1256

Query: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 1257 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1310

Query: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 1311 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1370

Query: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
              W+   ++  +     H                                      + T 
Sbjct: 1371 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1430

Query: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 1431 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1490

Query: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550

Query: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 1551 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1610

Query: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 1611 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1669

Query: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 1670 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 1726

Query: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 1727 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 1786

Query: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 1787 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 1846

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 1847 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 1901

Query: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 1902 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 1960

Query: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 1961 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2018

Query: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 2019 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2078

Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 2079 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2138

Query: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 2139 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2198

Query: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 2199 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2258

Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 2259 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2318

Query: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 2319 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2374

Query: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
                    V     E     DLS  ++    +A  S   EG  +  KD   +    +   
Sbjct: 2375 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2429

Query: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
             SA  S  Q +Q+ +   A  D++ + Q   + I +K      L   +K + K L   S 
Sbjct: 2430 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2489

Query: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
              + ++   E+ L + + S    + L     +T      W+    Q   +E ++K++L+K
Sbjct: 2490 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2544

Query: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
              ++   + ++W W+   +  LE+   ++   D    E  I KLK LQK +D    ++  
Sbjct: 2545 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2601

Query: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
            +N  +         +   + D    +  + D V   L   +  L++   + + F E+S  
Sbjct: 2602 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2661

Query: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
                L    E +D   +      SN    +LQ   K L  +KH++    L     QD+  
Sbjct: 2662 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 2718

Query: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
            +   +++GT   +   +V  I      L ++V      LE KL  +   Q  +    S  
Sbjct: 2719 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 2775

Query: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
                DELD+   V    GR     QK
Sbjct: 2776 AEFDDELDSMAPV----GRDAETLQK 2797



 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 415/2162 (19%), Positives = 824/2162 (38%), Gaps = 365/2162 (16%)

Query: 6806 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6862
            DL++W   +Q   DR E W     +V   LE  ++   A  EF      +SSLK + +S 
Sbjct: 284  DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 336

Query: 6863 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6922
                  LK     T   +L R++SQ+  LL N    QE+ H   +    SR A +E++ W
Sbjct: 337  IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 388

Query: 6923 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
            ++      +K+E+ +  +  +   +  + + K +  ++  +    +   +SV +I+ Q +
Sbjct: 389  LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 440

Query: 6983 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 7041
                  +        AM   W  ILQ     +  + E    ++ E+ N+ +    +    
Sbjct: 441  LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 498

Query: 7042 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7099
            +  +++++     +S+         LEDL++   +E E++ Q  + +A +  K + +  +
Sbjct: 499  KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 551

Query: 7100 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7154
                     +T   +  +    +I +    D       +SH+  +  I+    EA     
Sbjct: 552  KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 611

Query: 7155 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7208
             F +   + EAV +      Q  N+  L  +     +S+  +  + N++ +     V   
Sbjct: 612  CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 671

Query: 7209 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7253
             T         L  +  R+ + LE+  E Q+ S   + QL        Q Y++  K    
Sbjct: 672  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731

Query: 7254 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7293
              Q++                    EDR    ++    +D   + V   I +   L K L
Sbjct: 732  EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 790

Query: 7294 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
              +KD L  +    E+   Q  A+A+S++ + +  L+  L  + Q      T +   +  
Sbjct: 791  ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 847

Query: 7354 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7407
                 K+ +A EA +      +  EE +     +  + +ST+++   E+  +   F ++ 
Sbjct: 848  VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907

Query: 7408 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7456
             +L +   +   +    KE         ++   L   W  +  Q   R   L+     L 
Sbjct: 908  DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 967

Query: 7457 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7516
             ++      + W++ +  T++K+      N + L  Q    ++  +E+  +Q    S + 
Sbjct: 968  YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1023

Query: 7517 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
            + Q+  EQ     +D     +T                R ++DSQ +   + R M     
Sbjct: 1024 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1068

Query: 7577 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7636
              + E   L       V +  Q  +   D ++  E+                        
Sbjct: 1069 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1104

Query: 7637 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7692
               E +L+ E  E  EK K     L++    ++  LKD EK  K        S E++ T 
Sbjct: 1105 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1158

Query: 7693 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7750
            K++LS++L      L  H ++M  +E             Q+  L+++ +   S       
Sbjct: 1159 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1206

Query: 7751 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7806
                 L Q Q  +    + +  + + ER  E   + EK + +C+ LTQ E+++  +    
Sbjct: 1207 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1258

Query: 7807 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7852
              GD  +E        E+L+KD Q        + +  +  L++ GE+L+   KA  E K 
Sbjct: 1259 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1318

Query: 7853 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7905
            +E + K  ++N + +     L  ++   +K+  E + AV+QL+++   + +L  WL++++
Sbjct: 1319 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1378

Query: 7906 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7930
              SE A    K ++             S   EE                   Q  LN+Q 
Sbjct: 1379 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1438

Query: 7931 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7985
            +      ++ I +H   + +  +  +VLL       +  E + +Q+  + L   +    A
Sbjct: 1439 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1497

Query: 7986 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
             S E+++K+  + +   +KF  DY+ FE WL+ SE+      +          +LK+ ++
Sbjct: 1498 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1556

Query: 8045 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8092
            F   V      L  I     R+             + D++ +   +++ +     R+ +L
Sbjct: 1557 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1616

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8146
              +   +   LK  + + + +E A   +L  L     + T  +H SE       ++Q ++
Sbjct: 1617 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 1674

Query: 8147 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8204
            ++ KA Q +IS     +E++    E L++    L  A   I++ LD++    +++   V 
Sbjct: 1675 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 1734

Query: 8205 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS----PQPSSNLSLS 8260
              ++KL ++ L         R L ++D      L W      SL      P  S+ L   
Sbjct: 1735 ERNEKL-QITL--------TRSLSVQDGLD-EMLDWMGNVESSLKEQGQVPLNSTALQDI 1784

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD-KDFYLR 8319
            +++ +  E+      +S+++          ++  ++  M    PS     Q   KD   R
Sbjct: 1785 ISKNIMLEQDIAGRQSSINA----------MNEKVKKFMETTDPSTASSLQAKMKDLSAR 1834

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             +   S  H    +++ +L   ++      ++ +  + +KT    E+D   K   +L   
Sbjct: 1835 FSEA-SHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 1893

Query: 8380 CSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
               S      LEHK   E   SL   ++ H   +  A V+++   L  +    E  +K+ 
Sbjct: 1894 MQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEK 1951

Query: 8439 -------LQKWQQFNSDLNSIWAWLGDTEEE----------------LEQLQRLELSTDI 8475
                    ++   F   + S+ +W+ +T ++                LE  ++L+    +
Sbjct: 1952 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSL 2011

Query: 8476 QTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPEFTQADSKE------SRDL 8520
            +T E+Q        L  L  AV      I ++     + + E T  +++E         +
Sbjct: 2012 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2071

Query: 8521 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 8580
            +  ++ ++  ++ +  LL++    L   L + Q   E S  ++  L+ +++   +     
Sbjct: 2072 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2131

Query: 8581 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGN 8640
            +  D E ++   +Q    + EL ++  +V  L+D   +LL   E  D  EA         
Sbjct: 2132 APTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL--EENPDTPEAP-------- 2181

Query: 8641 RLKLLLKEVSRHIKELEKL-------LDVSSS--------QQDLSSWSSADELDTSGSVS 8685
            R K +L E+    +EL +L       L+ SS+        +  L  W    EL  S  + 
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS-VLG 2240

Query: 8686 PTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVL 8745
            P S    PN   T R +  +     +   P            LS PG   S RG +   L
Sbjct: 2241 PLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2298

Query: 8746 RA 8747
             A
Sbjct: 2299 AA 2300



 Score = 54.7 bits (130), Expect = 4e-06
 Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)

Query: 366  EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
            E ++Q L   G+ SLD A  + + +    S+L +W  + +KSL + L          E+A
Sbjct: 4274 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4322

Query: 425  LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
                           + I+ +L QHK+  ++  A     H +Y T +  G  +       
Sbjct: 4323 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4366

Query: 479  ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
                   D L ++ +++  +   S        E  L   +F +    L+  L   E +L 
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426

Query: 525  SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
                 +G  + V  L+ N+ +F    K   +   + Q LK++A   +  +GS +++  V 
Sbjct: 4427 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4481

Query: 585  KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
              M E + +W  +     S ++ LE  +   + + + V +L  WL +AE+      +L  
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541

Query: 639  SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
             E+A        K+F + L     +       G+ ++  C       +K  + ++  R+ 
Sbjct: 4542 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601

Query: 692  ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
            E+    KQ+ Q  A  +  +  K+E  + ++    +A T    K  E +      VK LI
Sbjct: 4602 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4661

Query: 747  QD----LEDIEQRVPVMDAQYKIITKT 769
             +    +E++ ++ P +D     +TKT
Sbjct: 4662 AEHQTFMEEMTRKQPDVDK----VTKT 4684



 Score = 33.9 bits (76), Expect = 7.3
 Identities = 90/474 (18%), Positives = 181/474 (38%), Gaps = 61/474 (12%)

Query: 8169 QGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELE 8228
            Q +QL+++      A + +E+  LR  C  V+ +      +  +L +      L+    +
Sbjct: 132  QADQLVQR-----VAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQ 186

Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
                +  S L        SL     SS+++  L+  + S  +   TPA     P      
Sbjct: 187  TLHPSLTSGL------TQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS----- 235

Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG--DHSALESQI-----RQLGKA 8341
              L  +  S +      E    Q  K   +R  +  S   D +  E +I     + L   
Sbjct: 236  -GLVPNFSSGV------EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 288

Query: 8342 LDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL 8401
            +D+ + Q+ +TE    S  P+      ++K   + + E  SS+      E K+ E + + 
Sbjct: 289  VDEMQVQLDRTE--WGSDLPSVESHLENHKNVHRAIEEFESSLK-----EAKISEIQMTA 341

Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEE 8461
            P        +   A  + R E   A+ L+     +++L     F S   +   WL + EE
Sbjct: 342  P-------LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 8462 ELEQLQRLELSTDIQTIELQIKKLK----ELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
            E       E++ D       I + K    EL + +D ++  I S+   + +    +    
Sbjct: 395  E-------EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPAR 447

Query: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHG--LLLMLENIDRRKNE 8575
              ++   + M  +W  +  L +     +++     + F++       L  L++  +RK  
Sbjct: 448  LTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK-- 505

Query: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEGTDC 8628
                D +     L+D  ++ M+ K ELL+ +  +A+L   +  ++ +    +DC
Sbjct: 506  -YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDC 558



 Score = 33.5 bits (75), Expect = 9.6
 Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)

Query: 375  DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
            D  L LD  L  ++  WD +  +  +   +L+++L         L  +  WLYR E  L 
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426

Query: 427  EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
            E+  V    +   N I       K+L + T    A KR+  E+      +   V   Q++
Sbjct: 4427 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4485

Query: 484  DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
            +++ R+  V + S     ++        EF  + + LL  L  AE  L+   +     ++
Sbjct: 4486 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545

Query: 536  VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
            +  L+  +  F                +K+  E   + + +    + V+   +     T 
Sbjct: 4546 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4589

Query: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
              W      +  +R+  EEV++   ++   +AS  A L            AK++    L 
Sbjct: 4590 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4632

Query: 652  HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
             W+Q       A   L +   E++ +++++   L+     + FME     Q D +D++ K
Sbjct: 4633 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 4683

Query: 712  EY 713
             Y
Sbjct: 4684 TY 4685


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  354 bits (909), Expect = 2e-96
 Identities = 725/4074 (17%), Positives = 1609/4074 (39%), Gaps = 457/4074 (11%)

Query: 1895 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1954
            N++   E +  ++DL    Q    L++ ++  D  L ++       SS    + R+  + 
Sbjct: 1087 NALRIAEQEHTQEDLQ---QLRSDLDAVSMKCDSFLHQSP------SSSSVPTLRSELNL 1137

Query: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014
            L  +++ +  L     ++   + V+ ++ QD   ELL  ++  E +  +E +      AL
Sbjct: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDA--ELL--VKGYEIKLSQEEVVLADLSAL 1193

Query: 2015 QQRLRVFNQLEDELNSHEHELCWLKD---KAKQIAQKDVAFAPEVDREINR-------LE 2064
            +           ++         L +   KAK +A++     PE + ++ R       L+
Sbjct: 1194 EAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253

Query: 2065 VTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWA 2124
              W      +   Q +   + +++ +Y+     + K +E          T   QE +K  
Sbjct: 1254 ERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEE---------TTAQQEMMKPG 1304

Query: 2125 FSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK 2184
             ++     ++   +Q  L     + +  L + +K  S  +S +  D E  +  +    E 
Sbjct: 1305 QAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF-SQQYSTIVKDYELQLMTYKAFVES 1363

Query: 2185 LEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRA-EELLKEFESE 2243
             +++  + R  LS  D +     ++       V    +++  + + LR  EE  K  E E
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE 1423

Query: 2244 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2303
             +    +++EL   V+ L   T+   T  +               KE T++ K  L+   
Sbjct: 1424 KQEHVEKVKELLGWVSTLARNTQGKATSSE--------------TKESTDIEKAILEQ-- 1467

Query: 2304 AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL 2363
                  +    ++TT   +V E++           +   K   K  + ++  IS   E L
Sbjct: 1468 ------QVLSEELTTKKEQVSEAIKT-------SQIFLAKHGHKLSEKEKKQIS---EQL 1511

Query: 2364 NSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL 2423
            N+L + YH     S  +         +  SQL  +T+    +  +    + +++   W  
Sbjct: 1512 NALNKAYHDLCDGSANQLQ-------QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVG 1564

Query: 2424 GAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT-------QEGQTLY 2474
             A+ A      RT   D   L+    DL+++ D + +  +    V        +E QT  
Sbjct: 1565 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT-- 1622

Query: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2534
              LS + +++++E++ +A E+++A  ++    ++ L++  +     E +  K        
Sbjct: 1623 -KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA------- 1674

Query: 2535 EERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRGQLLSEEGH- 2589
                  + L E+K+ I    + V  V    G+LL     +++LS    ++G L + +G+ 
Sbjct: 1675 -----AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729

Query: 2590 GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------EALEEALQSM 2636
            G  Q      + C  +   HQ LL   +  +   +S Q  L +H      E  +   Q +
Sbjct: 1730 GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKL 1789

Query: 2637 WFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL------------------------ 2671
                +     LA +E+ L    TL+  L + +QD                          
Sbjct: 1790 GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPE 1849

Query: 2672 ----LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------VIQTQLETL 2710
                L+K +G    ++   KG+             + +S KEG+       +++ +L+  
Sbjct: 1850 TLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 1909

Query: 2711 KEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP----QPG- 2765
             E +  + S      S L  ++ Q++ +    + L+ WM++ +  +E  L       PG 
Sbjct: 1910 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 1969

Query: 2766 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQEELKTQFNDI 2824
            L+E+      LQ  L+E +     L ++     E+  E   D        + + + F  +
Sbjct: 1970 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2029

Query: 2825 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS--- 2881
                 E+   +++ +       +++      +   ++ L      S  S   Q+ L+   
Sbjct: 2030 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2089

Query: 2882 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2941
            K+K+ I  ++        + +   E   +TTA+        +Q   A+  Q  + +   Q
Sbjct: 2090 KLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQRFEQLCLQQ 2142

Query: 2942 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3001
               E+ + ++    + F     +L+Q +E  S +L +         G   D++I   + +
Sbjct: 2143 QEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPDQDITHFFQQ 2193

Query: 3002 GQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQ 3059
             QE+   ++  +   + L+  + EL  C F+ DL  +  +V  L K++  L     +  +
Sbjct: 2194 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2253

Query: 3060 NKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENG 3117
            +     +Q   FRK  R FQ+WL   + +     +   +  E+   ++ ++  L +  + 
Sbjct: 2254 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASK 2312

Query: 3118 QHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN---------- 3160
               +  +  KG  L  L+ +  A   Q K       V ++      +H+           
Sbjct: 2313 GTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDM 2372

Query: 3161 -------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3207
                         LH+++ +L+ +  +M++    A  +  WL   E+++   S      P
Sbjct: 2373 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL--KSMDAMSSP 2430

Query: 3208 AK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFRHRVSQLSSQ 3260
             K    + + +  ++ L E+    P++ ++KE    L   +     +++++    +L+S+
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR 2490

Query: 3261 YLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT 3320
            +   + +T  +  +L+   +    F     +L+ W+ +   M+      + D ++L+++ 
Sbjct: 2491 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQK 2550

Query: 3321 LKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDMWASLLSAGI 3378
             +++ +L   + +  Q + +    + +L       + T  +Q++LQS+   W  L     
Sbjct: 2551 QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN 2610

Query: 3379 RCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAELRDKTTMLGK 3431
               SQ++ A+ K T YQ+ ++  S  + ++   L+       + E    +L + + +   
Sbjct: 2611 SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD 2670

Query: 3432 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQERAKEAVTKSE 3488
             + L+ EV    +L + + V    + E Y+    +  L+ +    + +++ A + + + +
Sbjct: 2671 LEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727

Query: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3548
              +   Q++Q+       WL  +Q +  +   +       ++ L++ +E Q    +    
Sbjct: 2728 AALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGS 2787

Query: 3549 LNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNNVVNKLRLME 3604
               ++   E ++ S  P  E R L++    L+  W+    + ++ +++  + + K +  +
Sbjct: 2788 YEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847

Query: 3605 QKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQE 3664
               + +  W++  + K+S   R   +    E  L + K    EV   R  +E + + A  
Sbjct: 2848 WHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906

Query: 3665 ILDESHVNSR-MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
            +++ S  +   +  +   +     A+  +       L+ +  SLEE    L  + + + +
Sbjct: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEE-------LQAKTGSLEEMTQRLREFQESFKN 2959

Query: 3724 THKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLE 3779
              K  +    +++  D +       K L+ L    + ++     +   R   +  V+   
Sbjct: 2960 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP 3019

Query: 3780 EG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEI 3838
            +G +A +L  +     ++  E+   V    + +E  L    +F  + + +   +A+  + 
Sbjct: 3020 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDE 3079

Query: 3839 L-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT 3891
            L          +  + ++ + +  L+K   L+  + + E   + + E+ E  L+L+    
Sbjct: 3080 LDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLG--- 3135

Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
            LK +++ L      L   GK     LE  +   ED+  +L+ +       +    A   +
Sbjct: 3136 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND-ATTAAEEAEALQWV 3194

Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQ 4011
              + +E I QQLA  K   +E      +++ LQMK   + G     +Q+  K      L+
Sbjct: 3195 VGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3248

Query: 4012 GTKDSYSAICST-----AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 4066
               +  +A  +T     AQR+ Q L+  L      QD L+   +WL+  + +L  + +PP
Sbjct: 3249 HDMEEINARWNTLNKKVAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPP 3306

Query: 4067 LSRAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQ 4112
             +  + +K Q++  + LQ   +  +  +D+L            + D    + +  + + +
Sbjct: 3307 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESR 3366

Query: 4113 QTE---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMK 4157
             TE         + +E  LV A+   +  E I    S     L +++       ++Q   
Sbjct: 3367 WTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI 3426

Query: 4158 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4217
             RH  LE +I +N  + V   VK  QS  +  +   + V  L++K +S + +  + + D+
Sbjct: 3427 IRHKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR 3482

Query: 4218 WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4277
                CR++  L    ++ L   R + +    V  +L +   +  ++   D +   +H + 
Sbjct: 3483 ---CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH 3535

Query: 4278 LKKLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRK 4335
               LAL   +  RK  ++      Q +++    ++  L++E+   ++ R+  +     + 
Sbjct: 3536 ADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKA 3595

Query: 4336 IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELE 4395
            ++      +     QS ++EL  W  E +  +A +  QSP  +           +  E+ 
Sbjct: 3596 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655

Query: 4396 AKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEK 4455
              +++L ++ + +  ++  +    R+ + K +SDA      +SD +GQR   ++ A+   
Sbjct: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715

Query: 4456 TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWA 4515
             Q+  A     + + + +RK+M    I L  D  + Q++  K+    +  +++ +  L++
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS 3775

Query: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
               E+     E++K+ +  K + L   Y+++    S R   LE+  V    F E +++  
Sbjct: 3776 HRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835

Query: 4576 HWLKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4633
             W+++  A I   P   + +E  +L  Q  + + + E   E++  +  L + G   L  L
Sbjct: 3836 PWIEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKEL 3892

Query: 4634 NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSEL 4690
            N  +   + EK       +  I    + +   + EA+       E+   IE   ++L  L
Sbjct: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952

Query: 4691 EAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ- 4748
             ++      +P ++  + E +S        L+++    EA+    ++  G RS G     
Sbjct: 3953 SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDL 4011

Query: 4749 -----PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSK 4803
                  DK+  +V  +  +K + E+R     D     +  EK    +   L ++K+ Q  
Sbjct: 4012 AAKEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDI 4068

Query: 4804 VNEETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQ 4857
            V++   P       +++++   ++          L+ + I   DL          + R  
Sbjct: 4069 VHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128

Query: 4858 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDL 4915
            I       + L     E + + E  M  ++ +Q  +    DWL    +K     PV  DL
Sbjct: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4188

Query: 4916 N-LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELS 4971
            N ++D   E++  K++++Q++++     M  L+H+ +    KA +    D +   L EL 
Sbjct: 4189 NTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELK 4243

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVES 5027
             L  ++ E +  RQ  L        ++    +    WL   +ELL     ++G   D + 
Sbjct: 4244 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKV 4300

Query: 5028 AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRM 5085
             E  L  H          H    ++ +  AT++ + K  G E LE      +  LRS R+
Sbjct: 4301 IEVELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RL 4348

Query: 5086 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------H 5136
               +     +LQ+   +    Q   ++     ++ E  L E + +++  S          
Sbjct: 4349 EAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4408

Query: 5137 EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRL 5195
             A E+L  H  L S + +  E    L +K   +  + +D+ S +   +S+  + Q+W  +
Sbjct: 4409 TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVV 4468

Query: 5196 RAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHD 5255
             +  ++++  LE+A++  T F N +++    +   +  L  +S        +L+ +E H 
Sbjct: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528

Query: 5256 TF----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
             F          ++EL+Q  + L  L Q+   +L             +   + ++Q R  
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWE 4575

Query: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLT 5365
             + ++    G+ +    K  +        +  W+++ + +L +  +EI    +++++ L+
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLS 4634

Query: 5366 EATNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQ 5414
            +    ++ +           +     KEK     T+LP + S +L     +++ + D + 
Sbjct: 4635 KHKEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVC 4688

Query: 5415 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKV 5464
             K  E +     +   S Q     + L   L K++ +           D V+      KV
Sbjct: 4689 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 4748

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
              +EL      +  L  + ++ +E +      +  ++ +L+       + + ++ S+L Q
Sbjct: 4749 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 4808

Query: 5525 AASHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID- 5580
            A    E + + + ++L+W+ +A + L       +    L+     H+  ++  E K +D 
Sbjct: 4809 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 4868

Query: 5581 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5640
            +   AM E +  +    C   +   +  +    EE+    K   Q L+ A  ++      
Sbjct: 4869 NSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL 4928

Query: 5641 LKKLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5689
            L++L A ++ A+ TL   +   +      +K  ++  Q  + EM   +P V  V
Sbjct: 4929 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982



 Score =  325 bits (834), Expect = 9e-88
 Identities = 863/4928 (17%), Positives = 1892/4928 (38%), Gaps = 646/4928 (13%)

Query: 2151 HLLSE--LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2208
            HL +E   K  HSS  S  +  M  T  + + +S   +E   R    L  W + +  + E
Sbjct: 547  HLKAEPLTKATHSSSTSWFRKPM--TRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604

Query: 2209 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLK----EL 2264
               W N+               L + EL  E +  +      +EEL S V + +    ++
Sbjct: 605  RAEWGND---------------LPSVELQLETQQHIHTS---VEELGSSVKEARLYEGKM 646

Query: 2265 TKNLETPPDLQFIEADLMQKLEHAK-EITEVAKGTLKDFTAQSTQVEKFINDITT---WF 2320
            ++N  T        A+ + KLE    ++ E +   ++   +    + KF++  T    W 
Sbjct: 647  SQNFHTS------YAETLGKLETQYCKLKETSSFRMRHLQS----LHKFVSRATAELIWL 696

Query: 2321 TKVEESLM--NCAQNETCEALKK--VKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
             + EE  +  + + N +  + K+    ++  EL+ +Q    S Q+    L  + H A+ +
Sbjct: 697  NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK-Q 755

Query: 2377 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKE--SS 2433
            ++      +  + + + QLC   +  ++E+     F    +E + +    + + K   S 
Sbjct: 756  TVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSC 815

Query: 2434 DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYA-------HLSKQIVSSIQ 2486
            D       LE  L D  +  + +   +S + ++    +T+         H+ K  +S   
Sbjct: 816  DHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTIS--- 872

Query: 2487 EQITKANEEFQAFLKQCLKDKQALQDCA--------SELGSFEDQHRKLNLWIHEMEERF 2538
              +    +  Q  +  C  D+  L+D +        S  G+         L     ++  
Sbjct: 873  --VKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAI 930

Query: 2539 N-TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRL 2597
                 + +S Q +    +++H     L      R+ LD L Q   L        G+  ++
Sbjct: 931  EMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLD-LVQTWNLEKLRSSAPGECHQI 989

Query: 2598 CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSK 2657
               L   +++ L+ +++   S   ++ +   LEE +++     KA    L  +      +
Sbjct: 990  MKNLQAHYEDFLQDSRD---SVLFSVADRLRLEEEVEAC----KARFQHLMKSMENEDKE 1042

Query: 2658 DTLEKR-LSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2716
            +T+ K  +S++++I L   E E ++   I    Q+L SS  +            ++ W D
Sbjct: 1043 ETVAKMYISELKNIRLRLEEYEQRVVKRI----QSLASSRTD------------RDAWQD 1086

Query: 2717 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHL 2776
                    + T E +            QL   +++V  K +  L   P       L   L
Sbjct: 1087 NALRIAEQEHTQEDL-----------QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135

Query: 2777 QSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE 2836
             ++L E  DH   L  +         KT D   +     EL  +  +I           E
Sbjct: 1136 -NLLVEKMDHVYGLSTVYLNKL----KTVDVIVRSIQDAELLVKGYEIKL-------SQE 1183

Query: 2837 EIVKDHLMYLDAVHEFTDWLHSAKEELHRW-SDMSGDSSATQKKLSKIKELIDSREIGAS 2895
            E+V   L  L+A      W       L  W SD+   +S      S + E I   ++ A 
Sbjct: 1184 EVVLADLSALEA-----HW-----STLRHWLSDVKDKNSV----FSVLDEEIAKAKVVAE 1229

Query: 2896 RLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2955
            ++SR   L PE                      D +++++   Q Q     +++Q+ + +
Sbjct: 1230 QMSR---LTPE-------------------RNLDLERYQEKGSQLQERWHRVIAQLEIRQ 1267

Query: 2956 QEFSGQVAQLEQALEQFSALLK----TWAQQLTLLEGKNTDEEIVECWHKGQEILDALQK 3011
             E       L         L+K    T AQQ  +  G+  D  ++      Q  L A   
Sbjct: 1268 SELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFA--- 1324

Query: 3012 AEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNC--LCLQASKGCQNKEQILQQRF 3069
                 E  +++L++  +FS+  ST       ++K+Y    +  +A    Q K    ++R 
Sbjct: 1325 ---EIERNQTKLDQCQKFSQQYST-------IVKDYELQLMTYKAFVESQQKSPGKRRRM 1374

Query: 3070 RKAFRDFQQWLVNAKIT-TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3128
              +     Q  ++ +   TA      Q++  +S +L++++E   E    + K   +    
Sbjct: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE--EEKVVEEEKQEHVEKVK 1432

Query: 3129 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3188
            ELL  + T   A+  Q K T+++             E A+   ++  ++     E + + 
Sbjct: 1433 ELLGWVSTL--ARNTQGKATSSETKEST------DIEKAILEQQVLSEELTTKKEQVSEA 1484

Query: 3189 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASK 3248
            +  ++  + +  ++L        E++K Q           QLN L +    L +G A   
Sbjct: 1485 IKTSQIFLAKHGHKL-------SEKEKKQ--------ISEQLNALNKAYHDLCDGSA--- 1526

Query: 3249 SFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCH 3308
               +++ QL SQ   L++ T++K      +  + N     +++L  W+  A   L  +  
Sbjct: 1527 ---NQLQQLQSQ---LAHQTEQKT-----LQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575

Query: 3309 PTS--DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNT----SPEGIPTIQQQ 3362
             T+  D S L      L+ L    Q +      +V   E  ++      SP  +  ++++
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635

Query: 3363 LQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAEL 3422
            L   K+ + +L       + +LE A++          Q           L E++++   L
Sbjct: 1636 LHQAKEQYEALQEETRVAQKELEEAVTS-------ALQQETEKSKAAKELAENKKKIDAL 1688

Query: 3423 RDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKE 3482
             D  T +G +     ++L+    +E  ++ GA + +  +      D  + Y  + +  ++
Sbjct: 1689 LDWVTSVGSS---GGQLLTNLPGME--QLSGASLEKGAL------DTTDGYMGVNQAPEK 1737

Query: 3483 AVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHC 3542
               + E +   HQE     + F +     Q  LDQ        H H  T  + Q LQ   
Sbjct: 1738 LDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ--------HGHNLTPEEQQMLQQKL 1789

Query: 3543 AEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRL 3602
             E +   ++ L   E         AE + +++L+ + Q +                    
Sbjct: 1790 GELKEQYSTSLAQSE---------AELKQVQTLQDELQKFL------------------- 1821

Query: 3603 MEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARA 3662
              Q  ++ + WL+ +E+++    +  S+  T    L +   + E+V +++ ++  V    
Sbjct: 1822 --QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879

Query: 3663 QEILD----------ESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESES 3712
            Q++LD           S + + +  +    T RY AL  +       L   +    + ++
Sbjct: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939

Query: 3713 SLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGE 3772
            S  S   W  +   N + + +     D  ++ ++L T + L +++ + H +     +K  
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE-HQVPVEKLQKVA 1998

Query: 3773 RAVKYLEEGEA---ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
            R +  +E   A     +++     +   + L+ ++ +    L+K +  ++   +  ++L 
Sbjct: 1999 RDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058

Query: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQD 3889
            Q I E ++ L   +   +     +  L+    L+Q +   + S+++ RE     +E    
Sbjct: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118

Query: 3890 VT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946
             T   L+ K+ ++   ++ LC   +E   SL+  +   E +     ++++++   S R++
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKS-RML 2177

Query: 3947 APDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNV 4006
            A        +    QQ+      ME+     D L +L     T +  C   L     Q+ 
Sbjct: 2178 ASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TELSSCGFALDLCQHQD- 2232

Query: 4007 HAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 4066
               +Q  +  ++ +  T +   +      ++    +  ++  Q WL   +  + P+ +  
Sbjct: 2233 --RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETS 2289

Query: 4067 LSRAEAIKQVKHFRALQE----QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL 4122
            +S  E  KQ++H ++L +    +     ++ C    L N  ++ TA D Q    +I   +
Sbjct: 2290 MSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2349

Query: 4123 VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKL 4182
              +     G+   K L +E+   + D                +N+    +  V      L
Sbjct: 2350 GSSVGSVNGYHTCKDL-TEIQCDMSD----------------VNLKYEKLGGV------L 2386

Query: 4183 QSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY 4242
              +Q S+  I+ ++ ++        HKE N +  QWL+            +E++ ++ D 
Sbjct: 2387 HERQESLQAILNRMEEV--------HKEANSVL-QWLE-----------SKEEVLKSMDA 2426

Query: 4243 HDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKM 4302
                   E              ++ AES    L  L++ +  +Q+ K A+  L      +
Sbjct: 2427 MSSPTKTET------------VKAQAESNKAFLAELEQNSPKIQKVKEALAGL------L 2468

Query: 4303 IEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEE 4362
            + + N  + E  K+    L  RW +  ++   + +    +   L   Q+   +L  W  E
Sbjct: 2469 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 2528

Query: 4363 QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMA---DLGLNE 4419
            ++  +      S  P+M          +  E EA++   + L + A  ++    D+ L+ 
Sbjct: 2529 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 2588

Query: 4420 RQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFR 4479
             QV ++  S  Q  V  L+D +  R   +++A+ + TQ+   +   + +++   +++  +
Sbjct: 2589 SQVQKELQSINQKWVE-LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647

Query: 4480 EHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQE 4538
              I   P+ V +Q++     ++ L+   +EV        EL   + EQ  K E+  +L+ 
Sbjct: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707

Query: 4539 LQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSEL 4598
            +      +    + R+  L+  L S + F++ FD+   WL            +  +   L
Sbjct: 2708 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 2767

Query: 4599 HTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-LSEKLNALPRQFNVIVA 4657
             +QL + +   +   ++      +   G+++L S+   +    L  +L  L   +  +  
Sbjct: 2768 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 2827

Query: 4658 LAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR 4717
               D+  ++++ +   ++Y   +E     + + +A+   +      + +E +L      +
Sbjct: 2828 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS---K 2884

Query: 4718 AILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ---RVSLLE 4774
            A+L+EV      ++ LN   +   ++ +  +         +   +   TE+   +   LE
Sbjct: 2885 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLE 2944

Query: 4775 DTTSAYQEHEKMCQQLERQLKSVKEE---------QSKVNEETLPAEEKLKMYHSLAGSL 4825
            + T   +E ++  + +E++++  K +         Q+  N+      EKL+    +  +L
Sbjct: 2945 EMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL----EKLRAQQEVLQAL 3000

Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
            +     L+  T  L + AP  D     +  HQ +  Q E   +   +       E+++  
Sbjct: 3001 EPQVDYLRNFTQGLVEDAP--DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3058

Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALS 4945
               F   +      L  +  EL G   +  +   +Q +I  +++   ++      + A  
Sbjct: 3059 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3118

Query: 4946 HKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAA 5005
             + +    +   L    L+  L  L++  G + E  + RQ  L     + + +Y+  +  
Sbjct: 3119 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGL 3178

Query: 5006 NDWLEDAQELLQLAGN-GLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
            ND    A+E   L    G +VE   + L     F   + D     L++++ L      LI
Sbjct: 3179 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLG---QGLI 3235

Query: 5064 KPTGKE----DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND 5119
            +  GK+     LE  +  +  R   +++    ++  LQ        +Q A E ++  + D
Sbjct: 3236 QSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD 3295

Query: 5120 TEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA 5179
            TE+ ++      ++     + ++ E K L  +++     +  L+ +  ++ ++   A + 
Sbjct: 3296 TEELIAN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3354

Query: 5180 TLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSA 5239
             ++  + ++  RWT L + A  ++K LED +     F+   +  ++ +   + KL  S  
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414

Query: 5240 EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQEI 5297
                 A++   +  H     ++E   + +    +  Q+LS L      +P E+  L ++I
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT-----SPAEQGVLSEKI 3469

Query: 5298 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE----- 5352
             ++Q R   +Q++      L+ Q L +  +       V  W+ E ++ L +  ++     
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529

Query: 5353 -IDAQLEELQILLTEATNHRQNIE---KMAEEQKEKYLGLYTILPSE----LSLQLAEVA 5404
             +  Q  +   L  E  N ++N++   K  +   ++  G   +L  E    +  + A++ 
Sbjct: 3530 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 3589

Query: 5405 L-DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQK 5463
            +   K    ++   +   + ++T +EL+  ++++ ++L T   +     + + Q +  QK
Sbjct: 3590 VTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQ-SPTGEQIPQFQQRQK 3648

Query: 5464 VLGEE-------LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAE 5516
             L +E       LD  N    E+  A+ + +    + G  L K +    E ++       
Sbjct: 3649 ELKKEVMEHRLVLDTVN----EVSRALLELVPWRAREG--LDKLVSDANEQYKLVSDTIG 3702

Query: 5517 NRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAHGTIAWNSASQLREQYILHQTLLE 5574
             R+ +++ A    ++Y +  +  L W+   K K++A G I      +L +     Q  ++
Sbjct: 3703 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI------RLEQDQTTAQLQVQ 3756

Query: 5575 ESKEID--SELEAMTEKLQYLTSVY--CTEK----MSQQVAELGRETEELRQMIKIRLQN 5626
            ++  ID     ++M E   + + ++  C E+    + ++   L ++ E +  +   R   
Sbjct: 3757 KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYAR 3816

Query: 5627 LQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEVGRLSLKEQLSHRQHLLSEMESLK 5683
            L+ A   + +F    ++L   +E+ +A    L SP +    L++Q    + L   +   K
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHK 3876

Query: 5684 PKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ- 5742
            P +  +      L+        + +     + +   ++++    Q+   +  AV Q  Q 
Sbjct: 3877 PHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQI 3935

Query: 5743 --YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 5800
              +  +++ + + +E     +   P+  + + +++  IS ++    +++  Q    +L  
Sbjct: 3936 TEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 3995

Query: 5801 KCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDGELLPTPSAHPSVVMMTAGRCHTL 5856
            + + L  +++ A   L   E++   +      ED+             V+ +     + +
Sbjct: 3996 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM 4055

Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
             + +T     +    ++ SP               ++  I   Q  +AE ++ +   +H 
Sbjct: 4056 AALLTTIKDTQDIVHDLESP--------------GIDPSIIKQQVEAAETIKEETDGLHE 4101

Query: 5917 STS-----ASQEFYEPGL--EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQ 5969
                     +   +  G   +P     + ++  +WE L     E+   L +A++   +YQ
Sbjct: 4102 ELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQ 4161

Query: 5970 DSLQSISTKMEAIELKLSESPEPG---RSPESQMAEHQALMDEILMLQDEINELQSSLAE 6026
            D+LQ++   ++   +KL   P  G    + + Q+ E +    E+   Q E+ +L     E
Sbjct: 4162 DTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-GE 4220

Query: 6027 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQ 6086
             ++ ++   D  ++  ++  LT L      +  K + ++  LE  L           AL 
Sbjct: 4221 LMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL----------LALG 4268

Query: 6087 RYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD---CQNMLVEIEQKVVALSEL 6143
            +++   +EL SWL  T+  LD       +P  +E +L      +N ++  +  V  +++ 
Sbjct: 4269 QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4328

Query: 6144 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE--ESD 6201
                 N LLE  A   D+A  L  +L  +      + +   +++  +Q T Q+ +   S+
Sbjct: 4329 G----NELLESSA--GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSE 4382

Query: 6202 VDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL 6259
            ++    +   ++  L+ ++ T    +  +  L    EL  +L  ++     +  +G  +L
Sbjct: 4383 IEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML 4442

Query: 6260 IQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSAEDQMRM--KWESLHQEF------ 6306
            +    + +     +   +L Q+       ME  KS  E+ + +  ++++  QEF      
Sbjct: 4443 LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTL 4502

Query: 6307 --------STKQKLLQNVLEQEQEQVLYSRP-----NRLL----SGVPLYKGDVPTQDKS 6349
                    S    +L  VL Q +E  +++       ++++    +G  L K     QD  
Sbjct: 4503 AEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQL-KFLSQKQDVV 4561

Query: 6350 AVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATA 6406
             + +LL  +   +E+V   S + G +   +    ++ ++       WL+D E  L     
Sbjct: 4562 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 4621

Query: 6407 LL--PEETETCLFNQEILAKDIKEMSEEMD---------KNKNLFSQAFPENGDNRDVIE 6455
            +   P++ +  L   +   K +       D         K K L     PE+    D   
Sbjct: 4622 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL----LPEDSQKLD--- 4674

Query: 6456 DTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVF 6515
                  LG +      V  +  + + +L++ L F         +L D  Y +  +LA   
Sbjct: 4675 ----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE-- 4728

Query: 6516 EQPVAEQIEAIQQAEDGLKEFD------AGIIELKRRGDKLQVEQPS------MQELSKL 6563
            +QPV   ++ +    D  K F        G +++ +R  +  +E           +L +L
Sbjct: 4729 DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQEL 4788

Query: 6564 QDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEI 6623
               +D +  +  S++S L Q L     +   +  L + L   ++ +   +  +    E +
Sbjct: 4789 STRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEAL 4847

Query: 6624 QQLLDKHKEYFQGLESHMI-----------------------------LTETLFRKIISF 6654
            Q L+D HKE+ + +E   +                             +    F +++++
Sbjct: 4848 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 4907

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSH---LDEDQQELSRQLEVVESS 6711
            A Q + +  T L    S ++  A      L +I   W+    +  DQ+ + + ++ V++ 
Sbjct: 4908 AKQHQQRLETAL----SELVANAELLEELLAWI--QWAETTLIQRDQEPIPQNIDRVKAL 4961

Query: 6712 IPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLIS--------I 6760
            I       E   R    +DR+T     K+    + P + +    G++ L          +
Sbjct: 4962 IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPIL 5021

Query: 6761 SCSDLES-QLNQLGECW-------LSNTNKMSKELHRLETILKHWTRYQSE--SADLIHW 6810
            S S+ ++ ++NQL   W       L    K++  L RLE  LK +  +  +      + W
Sbjct: 5022 SQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE-LKEFANFDFDVWRKKYMRW 5080

Query: 6811 LQSAKDRL 6818
            +   K R+
Sbjct: 5081 MNHKKSRV 5088



 Score =  317 bits (813), Expect = 3e-85
 Identities = 820/4346 (18%), Positives = 1669/4346 (38%), Gaps = 589/4346 (13%)

Query: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR-- 4564
            + EV    A+ + LMK +  ++K E + K+      Y S L+    RL+E E+ +V R  
Sbjct: 1019 EEEVEACKARFQHLMKSMENEDKEETVAKM------YISELKNIRLRLEEYEQRVVKRIQ 1072

Query: 4565 --KHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQLAKYQNILEQSPEYENLL 4619
                 + D D    W   A  +   E    +L    S+L     K  + L QSP   ++ 
Sbjct: 1073 SLASSRTDRDA---WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSV- 1128

Query: 4620 LTLQRTGQTILPSLN----EVDHSY--LSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4673
                    T+   LN    ++DH Y   +  LN L +  +VIV         +Q+A L  
Sbjct: 1129 -------PTLRSELNLLVEKMDHVYGLSTVYLNKL-KTVDVIVR-------SIQDAELLV 1173

Query: 4674 KEYA---SLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAV 4730
            K Y    S  E+    LS LEA +  +    +D+  + ++       ++LDE     + V
Sbjct: 1174 KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVF------SVLDEEIAKAKVV 1227

Query: 4731 DELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4790
             E   +    R+       +K   L   +HR+  Q E R S LE       ++      L
Sbjct: 1228 AEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTL 1287

Query: 4791 ERQLKSVKEEQSKVN----EETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP-- 4844
             + ++    +Q  +     E++    E+L    +L   ++ +   L +     +  +   
Sbjct: 1288 IKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIV 1347

Query: 4845 ---HLDPLAYEKARHQIQSWQGELKLLTS---AIGETVTECESRMVQSIDFQTEMSRSL- 4897
                L  + Y+      Q   G+ + + S   AI +   +  +R    +   T+  + + 
Sbjct: 1348 KDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS 1407

Query: 4898 DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4957
            D LRR++ E           + + EE +  Q H E+V+  L  ++ L+   + K T ++ 
Sbjct: 1408 DALRRLEEE-----------EKVVEEEK--QEHVEKVKELLGWVSTLARNTQGKATSSET 1454

Query: 4958 LISADLEHSLAELSELDGD-------IQEALRTRQATLT---------EIYSQCQRYYQV 5001
              S D+E ++ E   L  +       + EA++T Q  L          E     ++   +
Sbjct: 1455 KESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNAL 1514

Query: 5002 FQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDP 5061
             +A +D  + +   LQ   + L  ++ ++ L+        ++  H  LE+L S V   + 
Sbjct: 1515 NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQ------QNTCHQQLEDLCSWVGQAER 1568

Query: 5062 LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTE 5121
             +        +Q +++L+ ++Q   +D   Q D+  R T+    +    +++   M + +
Sbjct: 1569 ALAGHQGRTTQQDLSALQ-KNQSDLKD--LQDDIQNRATS----FATVVKDIEGFMEENQ 1621

Query: 5122 KKLSEFSLL----KTSSSHEAEEKLSEH---------KALVSVVNSFHEKIVALEEKASQ 5168
             KLS   L     K   + E  E L E          +A+ S +    EK  A +E A  
Sbjct: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
             +K   DA    ++   ++  Q  T L  + Q     LE    + T     V +A E +D
Sbjct: 1682 KKKI--DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 1739

Query: 5229 QLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPG 5288
            +  + +         KA    LL     F+L  +  Q+ L           Q G   TP 
Sbjct: 1740 KQCEMM---------KARHQELLSQQQNFILATQSAQAFLD----------QHGHNLTPE 1780

Query: 5289 EEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN 5348
            E+  L Q++                 G+L +Q        E ++  V+    E +++L +
Sbjct: 1781 EQQMLQQKL-----------------GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQD 1823

Query: 5349 PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LAEVAL- 5405
                     +E +  L  +    +N+ K     +         LPS L  Q   +E  + 
Sbjct: 1824 H--------KEFESWLERSEKELENMHKGGSSPET--------LPSLLKRQGSFSEDVIS 1867

Query: 5406 ---DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ 5462
               DL+       K+ ++E S    +E S +I  L KD      KLK  T+      +  
Sbjct: 1868 HKGDLRFVTISGQKVLDMENSFKEGKEPS-EIGNLVKD------KLKDATERYTALHSKC 1920

Query: 5463 KVLGEEL--------------DGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH 5508
              LG  L              D   + +   +A V+K L         + ++    T+  
Sbjct: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980

Query: 5509 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA--KVLAHGTIAWNSAS-QLREQ 5565
            Q+ + + +  + KL + A  + E         + +++    +L+H    + S S  L E+
Sbjct: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH----FQSLSYSLAER 2036

Query: 5566 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 5625
              L Q  + +S+ +   LE++ + +  +          +QV+ L      +++ +   ++
Sbjct: 2037 SSLLQKAIAQSQSVQESLESLLQSIGEVEQ----NLEGKQVSSLSSGV--IQEALATNMK 2090

Query: 5626 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS-----LKEQLSHRQHLLSEME 5680
              QD A+     EA  + +   +E A +T  +   G+L+      ++    +Q   S ++
Sbjct: 2091 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2150

Query: 5681 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 5740
             L P+ +  +     L+                +  E  SR+              +   
Sbjct: 2151 KLLPQAEMFEHLSGKLQ----------------QFMENKSRM--------------LASG 2180

Query: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS---------RHEELAQKI--- 5788
             Q +Q++ H  Q I+  + E+ED+      ++ L  ++S         +H++  Q +   
Sbjct: 2181 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240

Query: 5789 -----KGYQEQIASLNSKCKMLTMKAKHA-TMLLTVTEVEGLAEGTE-DLDGELLPTPSA 5841
                 K  +E+    +S  + L    K   T    + E EG    TE  +  + L     
Sbjct: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300

Query: 5842 HPSVVMMTAGRCHTLLSPVT-EESGEEGTNSEISSPPAC-RSPSPVANTDASVNQDIAYY 5899
            H   ++       TL+  +  + +  E    EI++P +  ++ S + +  +SV     Y+
Sbjct: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360

Query: 5900 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5959
                   +Q D                          + D+   +E L  V+ E+Q +L 
Sbjct: 2361 TCKDLTEIQCD--------------------------MSDVNLKYEKLGGVLHERQESLQ 2394

Query: 5960 EALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQ 6014
              L R ++      S+   +E+ E  L       SP    + ++Q   ++A + E+    
Sbjct: 2395 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2454

Query: 6015 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
             +I +++ +LA  LV+     +      +Q  L    ER + + +               
Sbjct: 2455 PKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----------- 2503

Query: 6075 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6134
            QLEE     A   ++    +L  WL+  +  +        +P  + AQ    Q ML E E
Sbjct: 2504 QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561

Query: 6135 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLN 6189
             +     +L+   + +L  G         Q+  +L+ +    +EL   L+ +     Q  
Sbjct: 2562 ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 2620

Query: 6190 MQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAE 6243
            ++ T  ++   D+        Q   VQ  ++       QQ + + + + +LEQ   E+ E
Sbjct: 2621 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKE 2680

Query: 6244 QKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAE 6292
             ++L   ++   GE+ L       ++  A    G    A ++ + L   L    +     
Sbjct: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740

Query: 6293 DQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLS 6334
            D++R   +    +       S K + LQ+ L++ +E            +V+ +    LL 
Sbjct: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL 2800

Query: 6335 GVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSA 6389
             VP      P ++K  + + L  L   +EE+S ++  A RQS     +   QK    V  
Sbjct: 2801 SVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVED 2852

Query: 6390 TSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 6448
               W++D + ++  +   L P + E+ L   + +  ++++    ++   +        + 
Sbjct: 2853 LVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE 2912

Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII- 6507
             + D I D    +   +  +   +  +   ++E  Q++  FQ   K +   +   K+ + 
Sbjct: 2913 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 2972

Query: 6508 ------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQ 6554
                   Q  +N   + +  Q E +Q  E   D L+ F  G++E    G      L   +
Sbjct: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3032

Query: 6555 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6614
             + QE  +++   +   +++ ++  G+ Q      +    L DL D L+ G   +  D  
Sbjct: 3033 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTD 3091

Query: 6615 IIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMA 6668
             + S  E+++  L+K       +E+      HM+  E     +    +++E +    L  
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNK 3145

Query: 6669 QASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 6725
            Q   + +R   R  +LE  L   E +    +   + +   E  E+    VG   E  ++ 
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205

Query: 6726 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTN 6781
            +    ++Q  K  ++  Q KL QV   G+ L+ S         LE  + ++   W +   
Sbjct: 3206 LADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263

Query: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6841
            K+++ + +L+  L H  ++Q     L+ WL   ++ +      S     E ++V+  +  
Sbjct: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQE 3319

Query: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQE 6900
                 + +D + +    + + G ++ +  ++ D   +  +L  ++S+WT+LL+   A Q+
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379

Query: 6901 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKI 6958
            +L  + +           +  ++S+ E  +   E      +G +   I + + ++K  + 
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEE 3434

Query: 6959 DINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
            DI      V     + QS+  ++S   +   S+K D      ++   +  +Q     K  
Sbjct: 3435 DIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAA 3488

Query: 7016 LLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 7074
            LL+  L +   + E+ V+ L    E ++K      +   Q  +     D   L + I  +
Sbjct: 3489 LLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR 3548

Query: 7075 EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSS 7134
            +K V++  +NG AL++    +   ++   L  +   +A++     +    L+      + 
Sbjct: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608

Query: 7135 HKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKF 7190
             +  ++++  +L E    L+     +G       Q+   Q  Q +L+K+       L   
Sbjct: 3609 FQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664

Query: 7191 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7250
              ++  LL+       E L   + + N ++  + + I +++    A +Q  Q+Y+    Q
Sbjct: 3665 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----Q 3720

Query: 7251 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7310
             A         T   L A     +  D+    +Q        +   KDS+  L     ++
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780

Query: 7311 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7370
                     + +Q    SL Q   A+     ++   L+   +    F ++ E L  WI E
Sbjct: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840

Query: 7371 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE--- 7426
               ++  Q PS + D   ++++ EE++      +   P +D+L ++G +L  LN +E   
Sbjct: 3841 TRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899

Query: 7427 -IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE 7482
              ++ Q     ++ I  +  +R   L   + Q      F +K E  +E L     +L + 
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959

Query: 7483 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLK 7536
              I      + E    ++    E+   Q    ++   G+ L+ + Q  D+D    E   K
Sbjct: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019

Query: 7537 LTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
            L  +   W+ +  RA++R      +++   + W     +   ++     V  L   G+  
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079

Query: 7593 VPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 7648
              I  Q   A T+ +E     +E  F+R  G+          L+ +     +  ++  + 
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSID 4130

Query: 7649 EIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRT 7691
            E+   W++ +   +E+ +KL   ++    ++   + + D L+               L T
Sbjct: 4131 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4190

Query: 7692 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7751
             K +L++ + +   E++ +Q+  ++L +          +L L K T        D  I+ 
Sbjct: 4191 VKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIR 4236

Query: 7752 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NG 7807
            E +  L+  WE L  +++ R+ ++   L     F    +EL  WLT  E  +      +G
Sbjct: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296

Query: 7808 DILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRW 7866
            D  + E +E  K    +   +A +  ++ + + G  L ++S    AS +  +L  +N  W
Sbjct: 4297 DPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4355

Query: 7867 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQR 7924
            + +L     R ++L+ TL   Q     +      L  +ES+L+  KP        E  + 
Sbjct: 4356 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETARE 4412

Query: 7925 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7984
            +L+   EL   ++        +L+   ++L   D   + ++ +   Q+   L+++W  + 
Sbjct: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVS 4469

Query: 7985 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 8044
            +   ER+ K+EE   L  +F +    F +WL  +E++    S   +I      ++++ + 
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 4529

Query: 8045 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8104
            F  +V+    Q+  +++   +L   ++      +K ++     RW+ + +R     R L 
Sbjct: 4530 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 4589

Query: 8105 HFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNK 8162
                + ++F  A   ++ WL + +  L + +E  ++ D ++ ++ + K FQ+ +      
Sbjct: 4590 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPV 4649

Query: 8163 IEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLPLPDDEH 8220
             +  I  G  L EK+  P D+  ++  L E+R     V G+ VER HK    L       
Sbjct: 4650 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 4709

Query: 8221 DLSDRELE---------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSG 8271
            D     ++          ED     DL       D+    Q          Q L+  RSG
Sbjct: 4710 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK--RSG 4767

Query: 8272 RD-----------TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE---------EGQ 8311
            R+               +  +   WD    LS   +S + +AL   +          E  
Sbjct: 4768 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 4827

Query: 8312 DDKDFYLRGAVGLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRSKTPTGP 8364
             + +  LR    L  D  AL+S I   ++  K +++ R  +       E I+       P
Sbjct: 4828 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL---AVCHP 4884

Query: 8365 ELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTAGVIDRW 8421
            +  T+ K ++ ++           R E  L   K+ ++ L         ET  + ++   
Sbjct: 4885 DCITTIKHWITIIR---------ARFEEVLTWAKQHQQRL---------ETALSELVANA 4926

Query: 8422 ELLQAQALSKELRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8480
            ELL+      +      +Q+ Q+    +++ + A + + +  +E++ R +   D  T   
Sbjct: 4927 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 4986

Query: 8481 QIKKLKEL------QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRV 8534
            + K ++        +     RK++        P  +Q+++K       R++Q++ RW +V
Sbjct: 4987 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLSARWQQV 5041

Query: 8535 CSLLEEWRGLLQDALMQCQGFHEMSH 8560
              L  E +  L DAL + +   E ++
Sbjct: 5042 WLLALERQRKLNDALDRLEELKEFAN 5067



 Score =  295 bits (754), Expect = 2e-78
 Identities = 808/4676 (17%), Positives = 1776/4676 (37%), Gaps = 536/4676 (11%)

Query: 1121 EDPDKWKDYTSRFSEFSSWIS------------TNETQLKGIKGEAIDTANHGEVKRAVE 1168
            E   +W++Y SR      WI              N  +LK +  + I   +  E +   +
Sbjct: 311  EVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI---HFKETEILAK 367

Query: 1169 EIRNGVTKRGETL--SWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALV 1218
            E   G  +    L   W++     L +    N+ +++  +L          L  + + L 
Sbjct: 368  EREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE 427

Query: 1219 TLLSEVEKMLSNFGDCVQYKEIVKNSLE---ELISGSKEVQEQAEKIL---DTENLFEAQ 1272
             LL    K+ +   +C +   + KN+L+     +   + VQ +++ I+   + E L    
Sbjct: 428  LLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQL 487

Query: 1273 QLLL-----HHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKL--ESTLDGLE 1325
            Q+ L      +  + + ++ +   +Q ++   +     L  +GH    +L   STL    
Sbjct: 488  QVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTH 547

Query: 1326 RSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL--SFSSLESLSSELEQTK 1383
               E   +    +   W R    +  +V         + RF+    S +E +  +LE+  
Sbjct: 548  LKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA- 606

Query: 1384 EFSKRTESIAVQAENLVK-EASEIPLGPQNKQLLQQQAK-------SIKEQVKKLEDTLE 1435
            E+     S+ +Q E       S   LG   K+    + K       S  E + KLE    
Sbjct: 607  EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE---T 663

Query: 1436 EDIKTMEMVKTKWDHFGSNFETLS------VWITEKEKELNALETS--SSAMDMQISQIK 1487
            +  K  E    +  H  S  + +S      +W+ EKE+E  A + S  +S +  + +   
Sbjct: 664  QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFS 723

Query: 1488 VTIQEIESKLSSIVGLEEEAQSF------AQFVTTGESARIKAKLTQIRRYGEELREHAQ 1541
                E+E K      L++ A+        A+      SA ++++L  +++    + +H +
Sbjct: 724  ELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVK 783

Query: 1542 CLEGT-ILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1600
              E T      S  ++ E  LR +Q S+     K        +S +    +LQ+ MD  +
Sbjct: 784  --ENTAYFQFFSDARELESFLRNLQDSI-----KRKYSCDHNTSLSRLEDLLQDSMDEKE 836

Query: 1601 ALESLSSAITAFSASARKVV-------------------------------NRDSCVQEA 1629
             L    S++ +    ++ +V                                 D CV E 
Sbjct: 837  QLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLED 896

Query: 1630 AALQQQY-----------------------EDILRRAKERQTALENLLAHWQRLEKELSS 1666
             + + ++                       +D +  A   + + + ++A W +L     S
Sbjct: 897  NSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKS 956

Query: 1667 FLTW--------------LERGEAKASSPEMDIS----------------------ADRV 1690
             ++W              LE+  + A      I                       ADR+
Sbjct: 957  LISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRL 1016

Query: 1691 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1750
            ++E E++  +A    ++      S   + KE   +     ++K ++L LE+ ++R     
Sbjct: 1017 RLEEEVEACKARFQHLMK-----SMENEDKEETVAKMYISELKNIRLRLEEYEQR----- 1066

Query: 1751 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD-H 1809
              + KRI  L S   +   + +  L  +          Q  S++  +  +     H+   
Sbjct: 1067 --VVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124

Query: 1810 AAEVESKKGELQSL---QGHLAKLGS--LGRAEDLHLLQGKAEDCFQLFEEASQVVERRQ 1864
            ++ V + + EL  L     H+  L +  L + + + ++    +D   L +     + + +
Sbjct: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEE 1184

Query: 1865 LALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAV 1924
            + L+ L+  L++H S    LR     V+  NS+     + I K    A Q ++      +
Sbjct: 1185 VVLADLSA-LEAHWS---TLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240

Query: 1925 SLD-----GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVL 1979
             L+     G   + ++H  I   E R S   +  ++ G+       L     E  A   +
Sbjct: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEM 1300

Query: 1980 KKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLK 2039
             K  Q +   +L   E + ++T      E  +  L Q  +   Q    +  +E +L   K
Sbjct: 1301 MKPGQAEDSRVLS--EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358

Query: 2040 ----------DKAKQIAQKDVAFAPE-----------VDREINRLEVTWDDTKRLIHENQ 2078
                       K +++     A   E           V      ++   D  +RL  E +
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418

Query: 2079 GQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2138
                   + + + + L   VS +  N      T +  K+  D++ A  + +    ++  K
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGK-ATSSETKESTDIEKAILEQQVLSEELTTK 1477

Query: 2139 QKDLDN-------FTSKGKHLLSEL-KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2190
            ++ +         F +K  H LSE  KK  S   + +        D   +  ++L+  + 
Sbjct: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537

Query: 2191 RLRVSLSIWDDVLSTRDEIE---GWSNNCVPQMA--------ENISNLDNHLRAEELLKE 2239
                  ++     +   ++E    W       +A        +++S L  +   +  LK+
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN---QSDLKD 1594

Query: 2240 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ---KLEHAKEITEVAK 2296
             + +++N+A     +   +    E  +   +P +L  +   L Q   + E  +E T VA+
Sbjct: 1595 LQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQ 1654

Query: 2297 GTLKDFTAQSTQVE--------------KFINDITTWFTKVEES----LMN--------- 2329
              L++    + Q E              K I+ +  W T V  S    L N         
Sbjct: 1655 KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSG 1714

Query: 2330 --------------CAQNETCEALKKVKDIQK----ELQSQQSN-ISSTQENLNSLCRKY 2370
                             N+  E L K  ++ K    EL SQQ N I +TQ     L +  
Sbjct: 1715 ASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 1774

Query: 2371 H--SAELESLGRAMTGLIKKHEAVSQLCSKTQ----ASLQESLEKHFSESMQEFQEWFLG 2424
            H  + E + + +   G +K+  + S   S+ +     +LQ+ L+K F +  +EF+ W   
Sbjct: 1775 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQDHKEFESWLER 1833

Query: 2425 AKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY--------AH 2476
            ++   +         + L + L    +  + V   +  L  VT  GQ +           
Sbjct: 1834 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 1893

Query: 2477 LSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME- 2535
               +I + +++++  A E + A   +C +    L     +   F++    L  W+   E 
Sbjct: 1894 EPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEA 1953

Query: 2536 --ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ 2593
              E+  ++ +      + E+     +++  L E     E L K+++   ++  EG  A  
Sbjct: 1954 NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DIMEIEGEPAPD 2011

Query: 2594 EGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACA 2650
               +      +L+  Q+L     E+    Q A+ + ++++E+L+S+   +  ++  L   
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071

Query: 2651 E-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQ 2706
            + S+L S   ++ L   +   QDI   K   E    M      + + +++     V+Q +
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV----TRFMETADSTTAAVLQGK 2127

Query: 2707 LETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGL 2766
            L  + + +  +       +S+L+ ++ Q   +     +L+Q+ME+  + +    QP   +
Sbjct: 2128 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDI 2187

Query: 2767 KEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMT 2826
               F  +  L   + + +++   L  L+ +        +    +D  Q  L+  F ++  
Sbjct: 2188 THFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ-NLRKDFTELQK 2246

Query: 2827 VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKEL 2886
              KE+ +      +    +   V  F  WL   +  +   ++ S  +   +K++  +K L
Sbjct: 2247 TVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETSMSAKELEKQIEHLKSL 2305

Query: 2887 IDS--------REIGASRLSR----VESLAPEVKQNT------------------TASGC 2916
            +D          EI     S     +E  AP+ +  T                  T    
Sbjct: 2306 LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL 2365

Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
              +  +M  +   +++    + + Q  L+ ++++M    +E   +   + Q LE    +L
Sbjct: 2366 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM----EEVHKEANSVLQWLESKEEVL 2421

Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
            K+    +  +      E +       +  L  L++  P+ + +K  L  L      L TY
Sbjct: 2422 KS----MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL------LVTY 2471

Query: 3037 SGKVSG-----LIKEYNCLCLQASKGCQNKEQILQQR------FRKAFRDFQQWLVNAKI 3085
                       + +E N    +A++    +++ L++       F+ A    + WL+  ++
Sbjct: 2472 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKEL 2531

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESE--NGQHKLNMMLSKGELLSTLLTKEKAKGI 3143
                   +  + + ++   Q++Q  L E E    QH+     ++G L            +
Sbjct: 2532 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 2591

Query: 3144 QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT----EKMVHES 3199
            Q ++ +  + W      L+ + S ++   ++   ++   E +QD   K     +++  +S
Sbjct: 2592 QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQ---ELLQDLSEKVRAVGQRLSVQS 2648

Query: 3200 SNRLYDLPAKRR--EQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQL 3257
            +        K++  E  +++S LE++     +   L ++   L   Q      + R+  +
Sbjct: 2649 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 2708

Query: 3258 SSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLD 3317
            +     L +L  ++++RL   +A   QF     EL+ W+ D        C  ++    L 
Sbjct: 2709 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 2768

Query: 3318 SRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP-EGIPTIQQQLQSVKDMWASLLSA 3376
            S+  + E       +     ++IV  GES+L +  P E   T+Q QL  +K+ W  L   
Sbjct: 2769 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 2828

Query: 3377 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLN 3436
                +S+L+  + K   YQ  V     W++  +A ++E       ++ ++++L    +LN
Sbjct: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888

Query: 3437 EEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKL 3490
             EV    SLLE +       +  +   E  +   E   + +   A+ E  +      E++
Sbjct: 2889 -EVEKRRSLLEILNSAADILINSSEADEDGIRD-EKAGINQNMDAVTEELQAKTGSLEEM 2946

Query: 3491 VRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLN 3550
             +  +E+Q   K  E  +   + +L+ +  L   A ++    ++L++L+      QAL  
Sbjct: 2947 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN----KNLEKLRAQQEVLQALEP 3002

Query: 3551 SVLHTRE--DVIPSGIPQAEDRA-----LESLRQDWQAYQHRLSETRTQFNNVVNKLRLM 3603
             V + R     +    P   D +      E  +Q++   + R++       N +  +   
Sbjct: 3003 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3062

Query: 3604 EQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQ 3663
              + +++   L   ++++        +  + + Q+  ++ +  ++   + ++E   A  +
Sbjct: 3063 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3122

Query: 3664 EILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
             +L+E      +G     L    +AL  Q     K  E      E+ E +L    D+Y  
Sbjct: 3123 HMLEEEGTLDLLG-----LKRELEALNKQC---GKLTERGKARQEQLELTLGRVEDFYRK 3174

Query: 3724 THKNFKNVATKIDKVDTV--MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG 3781
              K   +  T  ++ + +  ++G +++ +   L D +          +   + V  L +G
Sbjct: 3175 L-KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3233

Query: 3782 EAERLRKE-----IHDHMEQLKELTSTVRKE----HMTLEKGLHLAKEFSDKCKALTQWI 3832
              +   K+     +   ME++    +T+ K+       L++ L    +F D  + L  W+
Sbjct: 3234 LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWL 3293

Query: 3833 AEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL---LELVQD 3889
            A+ +E++   + P  E    KAQ+ + K LQ+ +   + +V  ++ +G  +    EL   
Sbjct: 3294 ADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADR 3353

Query: 3890 VTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPD 3949
              +  +++ L+S + +L S        LE  +   + ++   + +  +L     +L   +
Sbjct: 3354 EKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE 3413

Query: 3950 LLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAH 4009
             + T + + I QQ+  HKA+ E+I      ++     G +L    +   Q  L + + + 
Sbjct: 3414 PVGTQTAK-IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSL 3472

Query: 4010 LQGTKDSYSAICSTAQRMYQSLEHEL---QKHVSRQDTLQQCQAWLSAV------QPDLE 4060
                 +     C  A  + Q+L +     +  V   + L + +  LS+V      Q  L 
Sbjct: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 3532

Query: 4061 PSPQPPLSRAEAI--------KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQ 4112
                  L+  E I        + +K+ +AL +Q  T  ++L     L    +KT   DI 
Sbjct: 3533 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT-TGEEVLLIQEKLD--GIKTRYADIT 3589

Query: 4113 QTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMV 4172
             T     + L QA+ L     + +    EL  +L++ +++L     +    E       +
Sbjct: 3590 VTSSKALRTLEQARQLA---TKFQSTYEELTGWLREVEEELATSGGQSPTGE------QI 3640

Query: 4173 SQVKDFVKKLQSKQASVNTIIEKVNKLTK--------KEESPEHKEINHLNDQWLDLCRQ 4224
             Q +   K+L+ +      +++ VN++++        +      K ++  N+Q+  +   
Sbjct: 3641 PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDT 3700

Query: 4225 SNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLA--RSDAESTAVHLEALKKLA 4282
                  + +  +QR++ Y    +    ++ +   +   L   R + + T   L+  K  +
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760

Query: 4283 LALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTN 4342
            + +   K ++++L   + ++      + K +++E+T  L Q++  +  L   +       
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSER----YAR 3816

Query: 4343 LEELNVVQSRF----QELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
            LE   V+ ++F    +EL  W EE +  IA    Q P P       +DH  +  + E  +
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIA----QLPSP------AIDHEQLRQQQEEMR 3866

Query: 4399 MLLKSLIKDADRV---------MADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
             L +S+ +    +         + +L   E +++++    A++    + + V QR   L+
Sbjct: 3867 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC----KSAQASLKT 4505
            +A+S+ TQ      +    ++  E          L+P +V K ++ C    KSA   L+ 
Sbjct: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK-IRECISDNKSATVELEK 3985

Query: 4506 YQNEVTGLWAQGRELMKEVTEQEK----SEVLGKLQELQSVYDSVLQKCSHRLQELEKNL 4561
             Q     L  +G EL+      +K     E+  KL ++   ++ +  +   R  +    L
Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045

Query: 4562 VSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLT 4621
               + F  D       +K    +     +   + S +  Q+   + I E++      L  
Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105

Query: 4622 LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE 4681
            ++  G  ++ +  E +   + + ++ +   +  +    K++  K+++A+ A  +Y   ++
Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQ 4165

Query: 4682 LTTQSLSELEAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQK---- 4736
                 L     +   M  V TDL  V++ L+     +    EV      +++LN +    
Sbjct: 4166 AMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV---EVYQQQIEMEKLNHQGELM 4222

Query: 4737 -KEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK 4795
             K+    T +    + +  L  L+  L  +   R   LE    A  + +   ++L   L 
Sbjct: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282

Query: 4796 SVKE---EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4852
              +E    Q  ++ +    E +L  +H L   +      ++ V     +L          
Sbjct: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS 4342

Query: 4853 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4912
              R ++++     + +     E   + +S + Q+  F +E+   L  L R++++LS    
Sbjct: 4343 SLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKP 4402

Query: 4913 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELIS-ADLEHSLAELS 4971
                 +  +E++        ++++     N L  K +       +  S +  E S+A L 
Sbjct: 4403 TGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE 4462

Query: 4972 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG-NGLDVESAEE 5030
            +    +   +  R++ L E  +    +    Q   +WL  A++ L +A    L + +   
Sbjct: 4463 QKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLS 4522

Query: 5031 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRM---SR 5087
             ++ H  F +  +     + EL      L  L +      ++  + S++ R +++   S 
Sbjct: 4523 QIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 4582

Query: 5088 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKA 5147
            + G  +D  ++   Q+H+   A +++I+ + D E  L +  L  ++   + + +LS+HK 
Sbjct: 4583 ERGRSLDDARKRAKQFHE---AWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKHKE 4638

Query: 5148 LVSVVNSFHEKI-VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5206
                +          +    +  EKT        L   +  V  +W  +   + +++  L
Sbjct: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKL 4698

Query: 5207 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQS 5266
            E+A+     F + ++   + + +++ +L            ++ L++ H  F  EL ++  
Sbjct: 4699 EEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTG 4758

Query: 5267 ALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5326
             + +L++    ++++    T   +  L QE++   D    +    ++    ++Q LK  E
Sbjct: 4759 TVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRWDTVCKLSVSKQSR---LEQALKQAE 4814

Query: 5327 MVETQINSVKCWVQETKEYLGNPTIEIDAQL-EELQILLTEATNHRQNIEKMAEEQ 5381
            +    ++ +  W+ E ++     T+     L ++ + L +    H++ ++K+ E++
Sbjct: 4815 VFRDTVHMLLEWLSEAEQ-----TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR 4865



 Score =  293 bits (749), Expect = 7e-78
 Identities = 761/4237 (17%), Positives = 1608/4237 (37%), Gaps = 493/4237 (11%)

Query: 576  SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKM 635
            ++E A  V +   +  A W  L V  +S+ S        W+     +  +Q W  + EK+
Sbjct: 929  AIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQTW--NLEKL 978

Query: 636  LNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFM 695
             + +        +NL    +     +   + L    D +    L++++     R++ L  
Sbjct: 979  RSSAPGECHQIMKNLQAHYEDFL-QDSRDSVLFSVADRL---RLEEEVEACKARFQHLMK 1034

Query: 696  EVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQR 755
                      M+   KE T   + +S       K +   LE     V   IQ L      
Sbjct: 1035 S---------MENEDKEETVAKMYISEL-----KNIRLRLEEYEQRVVKRIQSLASSRTD 1080

Query: 756  VPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS-PLLYESQQLL 814
                      I +  H  T+E  Q+   ++ A   K    L +     S P L     LL
Sbjct: 1081 RDAWQDNALRIAEQEH--TQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLL 1138

Query: 815  IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEK 874
            +   +    +++ Y  L K+ + + V+ R  Q + L  + ++  L+ +E     L+ +E 
Sbjct: 1139 VEKMDHVYGLSTVY--LNKL-KTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195

Query: 875  GSQSVQKFVTLSNVL-KHFDQTRLQRQIADIHVAFQSMVKKTG----DWKKHVETNSRLM 929
               +++ +  LS+V  K+   + L  +IA   V  + M + T     D +++ E  S+L 
Sbjct: 1196 HWSTLRHW--LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253

Query: 930  KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 989
            +++    A+LE    I Q  LE     +E+L          D R  +  L    E T   
Sbjct: 1254 ERWHRVIAQLE----IRQSELESI---QEVLG---------DYRACHGTLIKWIEETTAQ 1297

Query: 990  PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLM 1049
             E  + G  E  R L +Q                   ++    A +E  +T+LD+  K  
Sbjct: 1298 QEMMKPGQAEDSRVLSEQLS-----------------QQTALFAEIERNQTKLDQCQKFS 1340

Query: 1050 PQEGSEKIIKEHRV------FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHV 1103
             Q  +  I+K++ +       F +       ++R  L     +     D    T  T  V
Sbjct: 1341 QQYST--IVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMD--LRTRYTALV 1396

Query: 1104 TLKELRAAIDSTYRKLMEDPDKW-----KDYTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
            TL        S   + +E+ +K      +++  +  E   W+ST     +G K  + +T 
Sbjct: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG-KATSSETK 1455

Query: 1159 NHGEVKRAVEEIR----NGVTKRGETLSWLKSRLKVLTEVS---SENEAQKQGDELAKLS 1211
               ++++A+ E +       TK+ +    +K+    L +     SE E ++  ++L  L+
Sbjct: 1456 ESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN 1515

Query: 1212 SSFKALVT-LLSEVEKMLSNFGDCVQYKEIVK--NSLEELISGSKEVQEQAEKILDTENL 1268
             ++  L     ++++++ S      + K + K  N+  + +        QAE+ L     
Sbjct: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575

Query: 1269 FEAQQLLLHHQQKTKRISAKKRDVQQQ---IAQAQQGEGGLPDRGHEEL--RKLESTLDG 1323
               QQ L   Q+    +   + D+Q +    A   +   G  +    +L  R+L +  + 
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635

Query: 1324 LERSRERQE----------RRIQVTLRKWERFETNKETVVRYLFQT-------------- 1359
            L +++E+ E          + ++  +    + ET K    + L +               
Sbjct: 1636 LHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSV 1695

Query: 1360 GSSHERFLS-FSSLESLSS----------------------ELEQTKEFSK-RTESIAVQ 1395
            GSS  + L+    +E LS                       +L++  E  K R + +  Q
Sbjct: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 1755

Query: 1396 AENLVKEASEIP---------LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
             +N +                L P+ +Q+LQQ+   +KEQ        E ++K ++ ++ 
Sbjct: 1756 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815

Query: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK--------VTIQEIESKLS 1498
            +   F  + +    W+   EKEL  +    S+ +   S +K        V   + + +  
Sbjct: 1816 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875

Query: 1499 SIVGLE--EEAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLE-----GTILGH 1550
            +I G +  +   SF +     E    +K KL         L  H++C         +LG 
Sbjct: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL--HSKCTRLGSHLNMLLGQ 1933

Query: 1551 LSQQQKFEENLRKIQQSVSE-----FEDKLAVPIKICSSATETYKVLQEHMDLCQA-LES 1604
              Q Q   ++L+   Q+          D +A    +      T K LQE +   Q  +E 
Sbjct: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 1993

Query: 1605 LSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
            L            +       VQE   ++   ++ +     ER + L+  +A  Q +++ 
Sbjct: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053

Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
            L S L  +   E      ++   +  V ++  L     L+ ++  Q S      ++    
Sbjct: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGV-IQEALATNMKLKQDIARQKSSLEATREMVTRF 2112

Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1781
               A      +++  L ++ +R+  L     ++ + L+ ++ + + F+ L      ++  
Sbjct: 2113 METADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN 2172

Query: 1782 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDL 1839
              ++  S  Q   +I+    Q+     ++   E+E ++  L +L+  + +L S G A DL
Sbjct: 2173 KSRMLASGNQPDQDITHFFQQI-----QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2227

Query: 1840 HLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
               Q + ++  + F E  + V+ R+   S   E L     L    ++  +  E   S+  
Sbjct: 2228 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK--ETEGSIPP 2285

Query: 1900 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKI---GSSEQRTSCRATADQLC 1956
             E+ +  K+L   +++ K+L      LD   SK     +I   G+S +      TA    
Sbjct: 2286 TETSMSAKELEKQIEHLKSL------LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQ 2339

Query: 1957 GEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQ 2015
            G+   I   +G+     +     K        E+   + D+  + +K   +    +++LQ
Sbjct: 2340 GKTGSILPSVGSSVGSVNGYHTCK-----DLTEIQCDMSDVNLKYEKLGGVLHERQESLQ 2394

Query: 2016 QRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIH 2075
              L    ++  E NS    L WL+ K + +   D   +P    +   ++   +  K  + 
Sbjct: 2395 AILNRMEEVHKEANS---VLQWLESKEEVLKSMDAMSSP---TKTETVKAQAESNKAFLA 2448

Query: 2076 ENQGQCC-------GLIDLMREYQNLKSAVS--KVLENASS--VIVTRTTIKDQEDLK-- 2122
            E +            L  L+  Y N + A +  K+ E  +S     T  T+  Q  L+  
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508

Query: 2123 ----------------WAFSKH----------------ETAKNKMNYKQKDLDNFTSKGK 2150
                            W   K                    K ++ +  K+ +    + +
Sbjct: 2509 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE 2568

Query: 2151 HLLSELKKIHS--SDFSL----VKTDMESTVDKWLDVSEKL---EENMDRLRVSLSIWDD 2201
             L    + I +   D SL    V+ +++S   KW+++++KL      +D+  V  + + +
Sbjct: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 2628

Query: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2261
            +L    E        V Q     S +     A +   E  SE+++    LE+L  +V + 
Sbjct: 2629 LLQDLSE----KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEA 2681

Query: 2262 KELTKNLETPPDLQFIEADLMQKLEHA-------KEITEVAKGTLKDFTAQSTQVEKFIN 2314
            + L   L      Q+++ +L ++LE         +++       L+   A + Q ++  +
Sbjct: 2682 QTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFD 2741

Query: 2315 DITTWF-TKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-----NSLCR 2368
            ++ TW   K  +   NC  +   E L+      +E Q   +  S + E +     + L  
Sbjct: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801

Query: 2369 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAK 2426
                 E  +L   +  L    E +S+  +  Q+ L++ ++K   +   +++   W    K
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861

Query: 2427 AAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQ 2486
            A   E    T D   LE+ L   + +L+ V   +S L+ +      L  + S+     I+
Sbjct: 2862 AKMSELR-VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL-INSSEADEDGIR 2919

Query: 2487 EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT-ENLGE 2545
            ++    N+   A  ++      +L++    L  F++  + +   +   + +    + LG 
Sbjct: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG- 2978

Query: 2546 SKQHIPEKKNEVHKVEMFLGELLAARE-SLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS 2604
              Q    K  E  + +    E+L A E  +D L    Q L E+        +L  Q   +
Sbjct: 2979 -SQACSNKNLEKLRAQQ---EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034

Query: 2605 HQNLLRMTKEKLRSCQVALQEHEALEE---ALQSMWFWVKAIQDRLACAESTLGSKDTLE 2661
             Q  L + +     C +   + E + +    ++ M+  +  + D L    +     D+L+
Sbjct: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094

Query: 2662 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQTQLETLKEVWADI 2717
               SQI+D+ L   +  V L + I   E   R   +E   +    ++ +LE L +    +
Sbjct: 3095 ---SQIEDVRLFLNKIHV-LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150

Query: 2718 MSSSVHAQSTLESVISQWNDYVERKNQLE------------QWMESVDQKIEHPLQPQPG 2765
                   Q  LE  + +  D+  +   L             QW+   + +I +       
Sbjct: 3151 TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3210

Query: 2766 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2825
            + +K   +D LQ  L +     + L +   K  ++     D        EE+  ++N + 
Sbjct: 3211 MFQK-EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLN 3262

Query: 2826 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK--- 2882
                +++ +++E +     + DA+     WL   +E +      S +    + ++ +   
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322

Query: 2883 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2942
            ++ L+D R+   + +  +++    + Q+   +  E +  ++++L + W +        Q 
Sbjct: 3323 LQRLLDDRK---ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379

Query: 2943 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG 3002
             LE++   + L++        Q  +  E  S  L    ++L   E   T         K 
Sbjct: 3380 QLEDI---LVLAK--------QFHETAEPISDFLSVTEKKLANSEPVGTQTA------KI 3422

Query: 3003 QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS-----GKVSGLIKEYNCLCLQASKG 3057
            Q+ +   +  E   E+  + +++  +  + LS+ +     G +S  I        +    
Sbjct: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482

Query: 3058 CQNKEQILQQRFRKAFR------DFQQWL--VNAKITTAKCFDIPQNI--SEVSTSLQKI 3107
            C  K  +L Q    A        +   WL  V  K+++    D  Q++   + +  L   
Sbjct: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 3542

Query: 3108 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3167
            +E ++  +N    ++  +  G+ L    T E+   IQ K+   K  + +      +    
Sbjct: 3543 EEIVNRKKN----VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598

Query: 3168 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3227
            LE  +     F+ + E +  WL + E+ +  S  +        + QQ+ + + +E+  + 
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658

Query: 3228 PQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3285
              L+ + E ++ L E     A +     VS  + QY  +S+   ++V  +D  +    Q+
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718

Query: 3286 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK--QEKEIQMKMIVTR 3343
                     W+ +    L +   P   +    +  L+++   S+   + K+   ++   R
Sbjct: 3719 EQAADAELAWVAETKRKLMA-LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777

Query: 3344 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3403
             E +      E    +Q++ +S+   + ++        ++LE A      + +   + S 
Sbjct: 3778 SE-IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836

Query: 3404 WMD---SMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI-----EVKGAG 3455
            W++   ++ A L      H +LR +     + + L E +  +   ++ +     ++K   
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQE---EMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893

Query: 3456 MTEHYVTQLELQDLQERYRAIQERAK-------EAVTKSEKLVRLHQEYQRDLKAFEVWL 3508
              E  + + + Q  +  Y  I+E  +       EAV++S ++   H + +  L+  E   
Sbjct: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE--- 3950

Query: 3509 GQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
                 +L    ++  +       + D +   V   + Q    ++    E++I       +
Sbjct: 3951 -NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009

Query: 3569 DRALESLRQD-------WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK- 3620
            D A + ++         W+  + R  E   +F +V   L L E+ +  +   L T ++  
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV---LELAEKFWYDMAALLTTIKDTQ 4066

Query: 3621 ----------VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESH 3670
                      + P   +Q   A + I+        EE     +E+E +     +++    
Sbjct: 4067 DIVHDLESPGIDPSIIKQQVEAAETIK--------EETDGLHEELEFIRILGADLIFACG 4118

Query: 3671 VNSRMGCQAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGST---H 3725
               +   + +  ++ + ++ L     E+++ LE+ +Q+  + + +L +  DW  +T    
Sbjct: 4119 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4178

Query: 3726 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAV-KYLEEGEAE 3784
                 V T ++ V   +   K   +EV  + +E     ++    +GE  + K  +E + +
Sbjct: 4179 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRD 4233

Query: 3785 RLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
             +R+ + +     + L   +      LE  L    +F    + L  W+   +E+L     
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV---QDVTLKDKIDQLQS 3901
               +    + +L+K+  L+  VL+H+ +V++V + G  LLE        +L+ +++ +  
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4353

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSL-ETIT 3960
             ++ +    +E    L++ ++  + ++SE+++    L +M  +L A     T  L ET  
Sbjct: 4354 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK--PTGGLPETAR 4411

Query: 3961 QQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 4020
            +QL  H  +  ++   E+  N L  KG  ++    D       +   A L+     +  +
Sbjct: 4412 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE---QKWHVV 4468

Query: 4021 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4080
             S  +     LE  L      Q++LQ+   WL+  +  L  +  P L     + Q++  +
Sbjct: 4469 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528

Query: 4081 ALQEQARTYLDLLCSMCDLSN-----------ASVKTTAKDIQ-QTEQTIEQKLVQAQNL 4128
                +   + D +  +    N             +K     +Q + E+ +++ + + ++L
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588

Query: 4129 TQGWEEIKHLK---SELWIYLQDADQQLQNMKRRHSELELNIAQNMV----SQVKDFVKK 4181
                +  K       +L  +L+DA+  L       SELE++   + +    S+ K+F K 
Sbjct: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLSKHKEFQKT 4642

Query: 4182 LQSKQASVNTIIEKVNKLTKKEESPEHKE-----INHLNDQWLDLCRQSNNLCLQREEDL 4236
            L  KQ   +T I     L +K   PE  +     +  + D+W  +C +S     + EE L
Sbjct: 4643 LGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL 4702

Query: 4237 QRTRDYHDCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIED 4294
              +  + D +  +  +L K   +   D     D +     ++A K     L +R   ++ 
Sbjct: 4703 LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQV 4762

Query: 4295 LKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQ 4354
            LK   +++IE+ + DD   VK Q   L  RW  +  L   K       L++  V +    
Sbjct: 4763 LKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 4821

Query: 4355 ELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4414
             L+EW  E +  +          +  Q+L+  H     ++E K++ + S +   + ++A 
Sbjct: 4822 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 4881

Query: 4415 LGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER 4474
               +    I+  ++  ++    +     Q ++ L  ALSE       + +  + IQ  E 
Sbjct: 4882 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAET 4941

Query: 4475 KIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
             ++ R+      + + + +   K+  A  +T+  E+T
Sbjct: 4942 TLIQRDQ-----EPIPQNIDRVKALIAEHQTFMEEMT 4973



 Score =  277 bits (708), Expect = 4e-73
 Identities = 782/4130 (18%), Positives = 1624/4130 (39%), Gaps = 503/4130 (12%)

Query: 4751 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4810
            +M HL +L+  + R T + + L E      +E E++         ++  +++  +E T+ 
Sbjct: 675  RMRHLQSLHKFVSRATAELIWLNE------KEEEELAYDWSDNNSNISAKRNYFSELTME 728

Query: 4811 AEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTS 4870
             EEK  ++ SL    QD        T  L  L  H      E     +QS    +K L  
Sbjct: 729  LEEKQDVFRSL----QD--------TAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCL 776

Query: 4871 AIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQ 4928
             + + V E  +       F ++      +LR ++  +      D N  L  +++ ++   
Sbjct: 777  CVEQHVKENTAYF----QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSM 832

Query: 4929 IHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD-GDIQEALRTRQAT 4987
              +E++  S   + +L  + K             L+++++  +  D   I+  +      
Sbjct: 833  DEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDEC 892

Query: 4988 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 5047
            + E  SQ  ++  +    N+ +  +   L    N   +E A    +S+ +  +   Q H 
Sbjct: 893  VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952

Query: 5048 NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY- 5106
            N + L S       L       DL Q     +LRS       G    +++   A + D+ 
Sbjct: 953  NTKSLISWNYLRKDL-------DLVQTWNLEKLRSSA----PGECHQIMKNLQAHYEDFL 1001

Query: 5107 QKAREEVIELMNDTEKKLSEFSLLKTSSSH---EAEEKLSEHKALVSVVNSFHEKIVALE 5163
            Q +R+ V+  + D  +   E    K    H     E +  E       ++      + LE
Sbjct: 1002 QDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061

Query: 5164 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5223
            E   ++ K     +    SR+    WQ    LR   Q+  +      ++     + +   
Sbjct: 1062 EYEQRVVKRIQSLAS---SRTDRDAWQD-NALRIAEQEHTQ------EDLQQLRSDLDAV 1111

Query: 5224 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML---- 5279
            +   D    + P SS+    ++EL  L+E  D  V  L    S + + + +T+ ++    
Sbjct: 1112 SMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD-HVYGL----STVYLNKLKTVDVIVRSI 1166

Query: 5280 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5339
            QD      G E  L QE   + D  L+  E   +  +    ++KD+  V + ++      
Sbjct: 1167 QDAELLVKGYEIKLSQEEVVLAD--LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224

Query: 5340 QETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE------EQKEKYLGLYTILP 5393
            +   E +   T E +  LE  Q   ++       +    E      E  ++ LG Y    
Sbjct: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284

Query: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI----------------QKL 5437
              L   + E     ++      K  + E S+  S++LS+Q                 QK 
Sbjct: 1285 GTLIKWIEETTAQQEMM-----KPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF 1339

Query: 5438 AKDLTTILT--KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5495
            ++  +TI+   +L+  T      ++ QK  G+        L   DA  Q+F++       
Sbjct: 1340 SQQYSTIVKDYELQLMTYKAF-VESQQKSPGKR----RRMLSSSDAITQEFMD------- 1387

Query: 5496 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE----YNEMLELILKWIEKAKVLAH 5551
             L  +   L  L  Q ++   + L +L +    +EE    + E ++ +L W+     LA 
Sbjct: 1388 -LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVS---TLAR 1443

Query: 5552 GTIAWNSASQLREQYILHQTLLEE---SKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5608
             T    ++S+ +E   + + +LE+   S+E+ ++ E ++E ++  TS     K   +++E
Sbjct: 1444 NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK--TSQIFLAKHGHKLSE 1501

Query: 5609 LGRE--TEELRQMIKIRLQNLQDAAKDMKKFEAEL--KKLQAALEQAQATLTSPEVGRLS 5664
              ++  +E+L  + K        +A  +++ +++L  +  Q  L++ Q T         S
Sbjct: 1502 KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCS 1561

Query: 5665 LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH 5724
               Q + R     +  + +  + A+Q  QS L+  +D + +     A +    E    ++
Sbjct: 1562 WVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620

Query: 5725 TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEEL 5784
                    + A   +  Q +++ + LQ+    A +E+E+    TS +Q+   +    +EL
Sbjct: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKEL 1678

Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPS 5844
            A+  K        +++    +T        LLT         G E L G  L   +   +
Sbjct: 1679 AENKK-------KIDALLDWVTSVGSSGGQLLTNLP------GMEQLSGASLEKGALDTT 1725

Query: 5845 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5904
                                G  G N         ++P  +   D       A +Q L +
Sbjct: 1726 -------------------DGYMGVN---------QAPEKL---DKQCEMMKARHQELLS 1754

Query: 5905 ERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5957
            ++     A     T ++Q F +       P  +     KLG+L+  + T       + + 
Sbjct: 1755 QQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 1809

Query: 5958 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILMLQ 6014
            +    +  QK+    +   + +E  E +L    + G SPE   S +    +  ++++  +
Sbjct: 1810 VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869

Query: 6015 DEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRMKASGKRQLLEE 6070
             ++  +  S  + L  E+   +  E   +    +  L    ER + +  K +     L  
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR----LGS 1925

Query: 6071 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQN 6128
             LN  L +  Q      ++  AD L +W+ + +A ++  LS     +P  ++ QL   + 
Sbjct: 1926 HLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979

Query: 6129 MLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRRLKGSLLELQRA 6182
            +  E+ +  V + +L  V  + + +EG+      H ++  + +    + L  SL E + +
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE-RSS 2038

Query: 6183 LHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---QSSLQQQKELEQ 6239
            L  K +    + QE  ES       QS G  E   + +   +      Q +L    +L+Q
Sbjct: 2039 LLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2093

Query: 6240 ELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
            ++A QKS L   R + +R  E     +AA   G   E      Q    + EK S+  ++ 
Sbjct: 2094 DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLD 6356
             + E + +  S K   LQ  +E +                 L  G+ P QD +     + 
Sbjct: 2154 PQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPDQDITHFFQQIQ 2195

Query: 6357 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 6416
             LN   E+        +++++   + L   +S+    LD  + +  V   L  + TE   
Sbjct: 2196 ELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN-LRKDFTELQK 2246

Query: 6417 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6476
              +E   KD     E++D+ + L           +  +++T G      S+  +  +   
Sbjct: 2247 TVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------SIPPTETSMSA 2292

Query: 6477 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6536
             +++++++ + +  +D     T + +     +       E  + E      Q + G    
Sbjct: 2293 KELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAPDSQGKTGSILP 2347

Query: 6537 DAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERAL 6595
              G       G     +   +Q ++S +   Y++L  ++  R+  L   L    +  +  
Sbjct: 2348 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407

Query: 6596 QDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH----MILTETLFRK 6650
              +   LE+ +E +     +   +K E ++   + +K +   LE +      + E L   
Sbjct: 2408 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2467

Query: 6651 IISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---DEDQQELSRQLE 6706
            ++++   +E +   ++  + ++  +RA +  V  +  LE + SHL      + +L   L 
Sbjct: 2468 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527

Query: 6707 VVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-----ISIS 6761
              E  +  +G +  + + L  +    Q +       + +  Q+ +  + +L     +S+S
Sbjct: 2528 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 2587

Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
             S ++ +L  + + W+  T+K++    +++  +   T+YQ    DL   +++   RL   
Sbjct: 2588 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647

Query: 6822 TQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQLLR---LKKVDT 6874
            +    Q   V Q+LE   +  +   +   EV +AQ+      +  G Q L+    K+++T
Sbjct: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707

Query: 6875 ATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 6934
              L   L  ++    D +  + A      Q Q           E+ +W+   ++   K  
Sbjct: 2708 VAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWLDDKQSQQAK-- 2756

Query: 6935 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQDVESKRSDKTD 6991
             N   S   + +   LQ+ + F+  +N    + + +    +S+L +S    E KR+    
Sbjct: 2757 -NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRT---- 2810

Query: 6992 FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRI 7051
               QL  +   W+ L     ++   L+  ++   +Y+ +V+ L  W E  + ++ +    
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870

Query: 7052 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI----------VM 7101
             D   ++++L   + + + ++ +   +E +      LI + + D   I          + 
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930

Query: 7102 STLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINSYLMEARYSLSR 7155
            +   EL     +L+ M  +L+   +S  +     + + H++  FD + S     + +L +
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK-NLEK 2989

Query: 7156 FRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 7215
             R     L+A++ QVD L+N    L +        GS  +QLL +      E L     E
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQEFL-----E 3040

Query: 7216 VNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQCASTVQQQEDR 7261
            V  R N+   ++E   E + Q    + +++ +  D            +   S   Q ED 
Sbjct: 3041 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3100

Query: 7262 TNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               L K    K DI   E      +C  +L+  GT+ D L    EL    KQ    +   
Sbjct: 3101 RLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEALNKQCGKLTERG 3154

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE-EILQGQD 7379
              + +QL L+  L  +E    K +     G+ D  T A+  EAL+ W+V  E EI+  Q 
Sbjct: 3155 KARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVVGTEVEIINQQ- 3205

Query: 7380 PSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWS 7438
                +D    Q E+++ L+ ++ + + +   L  +   G    +   E   M+ +N  W+
Sbjct: 3206 ---LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HDMEEINARWN 3259

Query: 7439 LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRA 7496
             ++ +  +R ++LQ  LL    F +  E  + +L  TE+ +A +   S  Y+ +  Q + 
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319

Query: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7556
             +L Q  +  R+  +  +  +G R+ +  ++ DR++   +L  L ++W  ++ +A  R+ 
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379

Query: 7557 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVF 7614
             ++  +   +++ E AE +  +L   S        S P+  Q A+     ++ K  E+  
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436

Query: 7615 LRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWKSASMRLEEQKK 7666
                      V+ G Q L S  S AE         +LQA  +EIQ++    +  L++   
Sbjct: 3437 ENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495

Query: 7667 KLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAEQM-RCKELENA 7720
                  +D  +    +A+  +KL     + FK+ +       H  L+ E + R K ++ A
Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555

Query: 7721 VGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 7780
            + +        +LLK T     + +++ ++ E+++ ++ ++ ++    S   + + +   
Sbjct: 3556 IKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604

Query: 7781 EWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAIAQENKIQLQQM 7839
                F    +EL  WL ++E +++ +G      E I + ++  +E      E+++ L  +
Sbjct: 3605 LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664

Query: 7840 GERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7895
             E +++A  E    +A E ++  +   N++++ + D I  RV ++   +   QQ ++   
Sbjct: 3665 NE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723

Query: 7896 SLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVL 7953
            +   W+A  + +L    PI  +    ++   +L  Q+    DI +H   +  + +    +
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780

Query: 7954 LHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 8013
               C     + +   +Q+ T +L +++  I  ++ ER  ++E    L  +F + Y     
Sbjct: 3781 FGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836

Query: 8014 WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 8073
            W++ +    A   S  + +   +++ ++    +  + E    ++ + K   +L   N  +
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896

Query: 8074 SACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILVWLTEMD- 8128
                  +MV E  Q+ +N+  ++   +R+    L   + Q  +     D I   L  ++ 
Sbjct: 3897 G-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951

Query: 8129 ---------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8179
                     L    ++   EC     I   K+   E+       E +  +GE+LI +S+ 
Sbjct: 3952 LSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006

Query: 8180 LD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8235
             D    A  I+++LD++  + +++  R E                   +RE++  D   L
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------EREIKFLDVLEL 4047

Query: 8236 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8295
            ++  W+D +A  L + + + ++   L  P       +    + ++I  E D    L  +L
Sbjct: 4048 AEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETD---GLHEEL 4103

Query: 8296 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI 8355
            E             G+ +K    +    ++     L    ++  + L+D+     Q ++ 
Sbjct: 4104 EFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDT 4163

Query: 8356 IRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 8405
            +++          K  T P + T        L E       V+  + +++ E+ +  G +
Sbjct: 4164 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQIEMEKLNHQGEL 4221

Query: 8406 NLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8456
             L     +T   I R         WE L  +   ++ +++  L    QF   L  + +WL
Sbjct: 4222 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4281

Query: 8457 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-K 8515
              TEE L+  +   +S D + IE+++ K   L+  V   +A + ++N    E  ++ +  
Sbjct: 4282 THTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGD 4339

Query: 8516 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 8575
            ++  L+ RL  MN  W+ V    EE    LQ  L Q QGFH      LL L  ++ + + 
Sbjct: 4340 DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA 4399

Query: 8576 IVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMSCQLLVNAEGTD 8627
              P         E L  H +   Q+K      ++LL+    +   +D S       +   
Sbjct: 4400 SKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4459

Query: 8628 CLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8677
             LE  +K HV+ ++++   +  S+  + L    +  +S Q+  +W +  E
Sbjct: 4460 LLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLAE 4504



 Score =  276 bits (706), Expect = 6e-73
 Identities = 853/4660 (18%), Positives = 1774/4660 (38%), Gaps = 700/4660 (15%)

Query: 3706 SLEESESSLSSYSDWYGSTHKNFK-NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
            S+EE  SS+     + G   +NF  + A  + K++T     K +T    ++ ++  H  +
Sbjct: 628  SVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLK-ETSSFRMRHLQSLHKFV 686

Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDK 3824
              A  +    + +L E E E L  +  D+   +    +   +  M LE+   + +   D 
Sbjct: 687  SRATAE----LIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742

Query: 3825 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
                    AE   + + P +  +E Y    Q S+ + ++Q  L  E  VK    +  A  
Sbjct: 743  --------AELLSLENHPAKQTVEAYSAAVQ-SQLQWMKQLCLCVEQHVK----ENTAYF 789

Query: 3885 ELVQDVT-LKDKIDQLQSDYQDLCSIGKEHVFS-LEAKVKDHEDYNSELQEVEKWLLQMS 3942
            +   D   L+  +  LQ   +   S       S LE  ++D  D   +L + +  +  + 
Sbjct: 790  QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLV 849

Query: 3943 GRLVAPDLLETSSLETITQQLAHHKAMME-----------EIAGFEDRLNNLQMKGDTLI 3991
            GR      L+  S + + +     KA+ +           +    ED     + K  +  
Sbjct: 850  GRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPT 909

Query: 3992 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQ---SLEHELQKHVSRQDTLQQC 4048
            G      +A +           KD+   + S  ++ YQ   +L H+L  HV+ +  +   
Sbjct: 910  GN-----EAMVPSVCFLIPPPNKDAIE-MASRVEQSYQKVMALWHQL--HVNTKSLI--- 958

Query: 4049 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4108
             +W + ++ DL+      L +  +    +  + ++     Y D L    D    SV  + 
Sbjct: 959  -SW-NYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRD----SVLFSV 1012

Query: 4109 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIA 4168
             D  + E+ +E    + Q+L +  E     ++   +Y+ +    L+N++ R  E E    
Sbjct: 1013 ADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE----LKNIRLRLEEYE---- 1064

Query: 4169 QNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE----INHLNDQWLDLCRQ 4224
            Q +V +++        + A  +  +    +   +E+  + +     ++   D +L     
Sbjct: 1065 QRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124

Query: 4225 SNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARS--DAE-----------ST 4271
            S+++   R E             +  V+L K  T  D + RS  DAE             
Sbjct: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV-DVIVRSIQDAELLVKGYEIKLSQE 1183

Query: 4272 AVHLEALKKLALALQERKYAIEDLKD--------------------QKQKMIEHLNLDDK 4311
             V L  L  L       ++ + D+KD                    Q  ++    NLD  
Sbjct: 1184 EVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLD-L 1242

Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE----LMEWAEE----- 4362
            E  +E+ S L++RW +    +  ++++  + LE +  V   ++     L++W EE     
Sbjct: 1243 ERYQEKGSQLQERWHR----VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQ 1298

Query: 4363 --------------------QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLK 4402
                                Q    AE  +     D  Q     +  I  + E + M  K
Sbjct: 1299 EMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358

Query: 4403 SLIKDADRVMADLG--LNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLM 4460
            + ++   +        L+    I +   D ++    L  L  Q  KY++ AL    +   
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418

Query: 4461 AVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
             V +   + Q+H  K+         + R          +K+    + A    +    E+T
Sbjct: 1419 VVEE---EKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELT 1475

Query: 4512 GLWAQGRELMK-----------EVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4560
                Q  E +K           +++E+EK ++  +L  L   Y  +    +++LQ+L+  
Sbjct: 1476 TKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ 1535

Query: 4561 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4620
            L  +   K                      L  + +  H QL   +++     + E  L 
Sbjct: 1536 LAHQTEQK---------------------TLQKQQNTCHQQL---EDLCSWVGQAERALA 1571

Query: 4621 TLQ-RTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD--KFYKVQEAILARKEYA 4677
              Q RT Q  L +L + + S L +  + +  +      + KD   F +  +  L+ +E  
Sbjct: 1572 GHQGRTTQQDLSALQK-NQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELT 1630

Query: 4678 SLIELTTQSLSELEA--QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQ 4735
            +L E   Q+  + EA  +  R+++   + AV  AL  +        E+A   + +D L  
Sbjct: 1631 ALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLD 1690

Query: 4736 KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK 4795
                  S+G      ++L  +    +L   + ++ +L  DTT  Y    +  ++L++Q +
Sbjct: 1691 WVTSVGSSG-----GQLLTNLPGMEQLSGASLEKGAL--DTTDGYMGVNQAPEKLDKQCE 1743

Query: 4796 SVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKAR 4855
             +K      ++E L  ++   +    A +  D          H  +L P        + +
Sbjct: 1744 MMKAR----HQELLSQQQNFILATQSAQAFLDQ---------HGHNLTP--------EEQ 1782

Query: 4856 HQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD-------WLRRVKAELS 4908
              +Q   GELK   S    ++ + E+ + Q    Q E+ + L        WL R + EL 
Sbjct: 1783 QMLQQKLGELKEQYST---SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELE 1839

Query: 4909 GPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLA 4968
                   + + +   +++     E+V         +SHK   +F         D+E+S  
Sbjct: 1840 NMHKGGSSPETLPSLLKRQGSFSEDV---------ISHKGDLRFVTISGQKVLDMENSFK 1890

Query: 4969 E---LSELDGDIQEALRTRQATLTEIYSQCQRY----------YQVFQAANDWLEDAQEL 5015
            E    SE+   +++ L+      T ++S+C R           Y  FQ + D L+   + 
Sbjct: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950

Query: 5016 LQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED----- 5070
             +     L  ++   +     E  +T  Q    L E    V  L  + +   + +     
Sbjct: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010

Query: 5071 ----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSE 5126
                +++   S+    Q +S     +  LLQ+  AQ    Q++ E +++ + + E+ L E
Sbjct: 2011 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNL-E 2069

Query: 5127 FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMT 5186
               + + SS   +E L+ +  L   +      + A  E  ++  +T +  + A L   + 
Sbjct: 2070 GKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLA 2129

Query: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246
             V QR+ +L    Q++E  L+  + +   F +   K  + ++     L   +       +
Sbjct: 2130 EVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQ---D 2186

Query: 5247 LLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLN 5306
            +    +      LE+E QQ  L  L      +   G A           ++   QDR  N
Sbjct: 2187 ITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFA----------LDLCQHQDRVQN 2236

Query: 5307 MQEKVKTNGKLVKQELKDREMVETQINSVKC-------WVQETKEYLGNPTI------EI 5353
            +++      K VK+  KD    + Q++  +        W++ET+  +  PT       E+
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIP-PTETSMSAKEL 2295

Query: 5354 DAQLEELQILLTE--------------ATNHRQNIEKMAEEQKEKYLGLYTILPSELSL- 5398
            + Q+E L+ LL +               T+    I ++     +   G  +ILPS  S  
Sbjct: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG--SILPSVGSSV 2353

Query: 5399 ----------QLAEVALDLKIRDQIQDKIKEVEQSKATS-QELSRQIQKLAKDLTTILTK 5447
                       L E+  D+   +   +K+  V   +  S Q +  +++++ K+  ++L  
Sbjct: 2354 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2413

Query: 5448 LKAK---------------TDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ--N 5490
            L++K               T+ V       K    EL+  + K+ ++  A+   L    N
Sbjct: 2414 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN 2473

Query: 5491 GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK--- 5547
             Q  +   K   +L    ++       R  +L ++ASHL  +      +  W+ + +   
Sbjct: 2474 SQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMM 2533

Query: 5548 -VLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEK 5601
             VL   +I  N  +  ++Q    Q +L+E +    + E + E  Q + +        T +
Sbjct: 2534 GVLGPLSIDPNMLNAQKQQV---QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 2590

Query: 5602 MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAA-------LEQAQAT 5654
            + +++  + ++  EL   +  R   +  A     +++  L+ L          L    A 
Sbjct: 2591 VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAI 2650

Query: 5655 LTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ-LCQS-ALRIPEDVVASLPLCHAA 5712
             T PE    ++K+QL     + S++E L  +V+  Q LC   ++ I E  +         
Sbjct: 2651 STQPE----AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD----ELK 2702

Query: 5713 LRLQEEASRLQ---HTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5769
             RL+  A  LQ     A  + N +QAA+   +Q++Q    L+  ++    +       ++
Sbjct: 2703 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 2762

Query: 5770 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5829
             ++ LQ+Q+  +EE       +Q+ +   +   +++   A+  ++LL+V       E   
Sbjct: 2763 KLERLQSQLQENEE-------FQKSLNQHSGSYEVIV--AEGESLLLSVPP----GEEKR 2809

Query: 5830 DLDGELLPTPSAHPSVVMMTAGRCHTL----------------LSPVTEESGEEGTNSEI 5873
             L  +L+   +    +   TA R   L                L P  E+   + +   +
Sbjct: 2810 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 2869

Query: 5874 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA 5933
            +  P  +  S +  + A +N+     +  S   +   AA I  ++S   E  E G+    
Sbjct: 2870 TLDPV-QLESSLLRSKAMLNE---VEKRRSLLEILNSAADILINSS---EADEDGIRDEK 2922

Query: 5934 TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI--ELKLSESPE 5991
                  + ++ + +   +  K  +L E  +R +++Q+S ++I  K+E    +L++ ++  
Sbjct: 2923 AG----INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978

Query: 5992 PGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLA 6051
                    + + +A  + +  L+ +++ L+ +  + LV ++ +   A QL  Q+   V  
Sbjct: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLR-NFTQGLVEDAPDGSDASQLLHQA--EVAQ 3035

Query: 6052 ERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALS 6111
            +    ++ + +    ++E KL          + + ++ C   E+ S L      LD   +
Sbjct: 3036 QEFLEVKQRVNSGCVMMENKL----------EGIGQFHCRVREMFSQLADLDDELDGMGA 3085

Query: 6112 PPKEPMDMEAQLMDCQNML-------VEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQ 6164
              ++   +++Q+ D +  L       ++IE        +      L L G     +   +
Sbjct: 3086 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3145

Query: 6165 LAGKL-RRLKGSLLELQRALHD--------KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
              GKL  R K    +L+  L          K LN   TA E+ E+   +  T+   + + 
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205

Query: 6216 LAQARTTWTQQ---RQSSLQQ---------------------QKELEQELAEQKSLLRSV 6251
            LA  +    +Q    Q  LQQ                     + ++E+  A   +L + V
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265

Query: 6252 ASRGEEILIQHSAAETSGDAGEKPDVLSQELG--MEGEKSSAEDQMRMKWESLHQEFSTK 6309
            A R  ++       E     G+  D L   L    + E+  A  +       + +    +
Sbjct: 3266 AQRIAQL------QEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319

Query: 6310 QKLLQNVLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSS 6367
            QKLLQ +L+  +  V  L +   R+     L        D+  +T  L+ L   + E+ S
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAEL-------ADREKITGQLESLESRWTELLS 3372

Query: 6368 QSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAK 6424
            ++   ++Q    + L ++ ++     S +L   E++L  +    P  T+T    Q+I+  
Sbjct: 3373 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE---PVGTQTAKIQQQIIRH 3429

Query: 6425 DIKEMSEEMDKNKNLFSQAFP--------ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6476
              K + E+++ +     QA           +   + V+ + +  L  R S +     ++ 
Sbjct: 3430 --KALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKA 3487

Query: 6477 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6536
              + + L     F  D   +   LA+    +  KL++VF +   + +   Q A+      
Sbjct: 3488 ALLDQALSNARLFGEDEVEVLNWLAE----VEDKLSSVFVKDFKQDVLHRQHADH--LAL 3541

Query: 6537 DAGIIELKRRGD------KLQVEQPSMQELSKLQD-------MYDELMMIIGSRRSGLNQ 6583
            +  I+  K+  D      +  ++Q + +E+  +Q+        Y ++ +        L Q
Sbjct: 3542 NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQ 3601

Query: 6584 NLTLKSQYERALQDLADLLETGQEKMA--GDQKIIVSSKEEIQQLLDKHKEYFQGLESHM 6641
               L ++++   ++L   L   +E++A  G Q     + E+I Q   + KE  + +  H 
Sbjct: 3602 ARQLATKFQSTYEELTGWLREVEEELATSGGQS---PTGEQIPQFQQRQKELKKEVMEHR 3658

Query: 6642 ILTET---LFRKIISFAVQKETQFHTELMAQAS------------------AVLKRAHK- 6679
            ++ +T   + R ++     +  +   +L++ A+                  A ++R+ + 
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718

Query: 6680 ---RGVELEYILETWSHLDE------DQQELSRQLEVVESSIPSVGLVEENEDRLIDRI- 6729
                  EL ++ ET   L        +Q + + QL+V ++    +   +++ D L     
Sbjct: 3719 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 3778

Query: 6730 ----TLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ---LNQLGEC------W 6776
                T  +  K+ L E    L Q   +   LL S   + LE     +NQ  E       W
Sbjct: 3779 EIFGTCGEEQKTVLQEKTESLIQQY-EAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837

Query: 6777 LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDR----LEFWTQQSVTVPQEL 6832
            +  T  +  +L       +   + Q E   L   +   K      L+   Q     P+E 
Sbjct: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 3897

Query: 6833 EMVRDHL----NAFLEFSKEVDAQSSLKSSVLSTGNQLLRL-KKVD--TATLRSELSRID 6885
            EMV +      N + +  +EV  ++      +S   Q+     K++    TL +  SR+ 
Sbjct: 3898 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL- 3956

Query: 6886 SQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--- 6942
                 +   IPA  +K+ +   D   ++ A  E+       E + ++ E+ I  S G   
Sbjct: 3957 ----RMPPLIPAEVDKIRECISD---NKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009

Query: 6943 ---YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQ------------------- 6980
                K I + L +   F  DI  +    +     VL+++ +                   
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4069

Query: 6981 -DVESKRSDKTDFAEQLGAMNKSWQILQGL-----------------------------V 7010
             D+ES   D +   +Q+ A     +   GL                             +
Sbjct: 4070 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129

Query: 7011 TEKIQLLEGLLESWSE--------------YENNVQCLKTWFETQEKRLKQQHRIG-DQA 7055
             E     E L ++W E              Y++ +Q +  W +    +L     +G D  
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189

Query: 7056 SVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVS-SIVMSTLRELGQTWANL 7114
            +V++ L + ++ +  +  ++ E+EK+   G  +++   ++    I+   L EL   W NL
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4249

Query: 7115 DHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQ 7174
               +   +  L+  L      + A +++ S+L      L   R ++G  + ++V++    
Sbjct: 4250 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4309

Query: 7175 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7234
             L++D+   + +++      N+LL+        +L + L+ +N  W ++L++  E+ Q  
Sbjct: 4310 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4369

Query: 7235 KALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLG 7294
            ++ LQ  Q +    +     + + E + +         + A +++ T +    +L   L 
Sbjct: 4370 QSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM----ELYSQLK 4425

Query: 7295 TVKDSLFFLHELGE-QLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7353
              +++   L + G   L  + D+ + S  +     L Q    +   + ++++ L+  +  
Sbjct: 4426 AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNL 4485

Query: 7354 YETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRL 7413
               F  SL+    W+  AE+ L    P  S  L+T+  ++EE K    + ++    +  L
Sbjct: 4486 ATEFQNSLQEFINWLTLAEQSLNIASPP-SLILNTVLSQIEEHKVFANEVNAHRDQIIEL 4544

Query: 7414 NELGYRLPL--NDKEIKRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCET 7467
            ++ G +L      +++  ++NL       W  +  ++ ER   L     + + F E  + 
Sbjct: 4545 DQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKK 4604

Query: 7468 WMEFLVQTEQKL--AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 7525
             +++L   E  L   +EIS +   +  Q   H+ FQ  +  +Q +  + I  G+ L E+ 
Sbjct: 4605 LIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKT 4664

Query: 7526 QV-DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 7584
             + +D  + +  L  + ++W  V  ++ +R+  ++  +    ++ +  + L  WL +V  
Sbjct: 4665 LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE- 4723

Query: 7585 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
              ++    V   L     L D  +  +K   ++ G+  +   +G++L+ ++       ++
Sbjct: 4724 PQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT-TWVK 4782

Query: 7645 AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL--SQSLPD 7702
             +L E+  +W +       ++ +L   LK  E     +   LE L   ++ L    +LPD
Sbjct: 4783 GQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPD 4842

Query: 7703 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE 7762
              E L +     KE    V     D+     + + + A    D I+ +   + +++ ++E
Sbjct: 4843 DTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFE 4902

Query: 7763 ELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK--- 7819
            E+       +Q++   L+E    +E  +EL  W+   E+ + Q     I + I+++K   
Sbjct: 4903 EVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALI 4962

Query: 7820 ---KDYQEEIAIAQENKIQLQQMGERL------AKASHESKA-----------------S 7853
               + + EE+   Q +  ++ +  +R       A    +S++                 S
Sbjct: 4963 AEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILS 5022

Query: 7854 EIEYKLGKVND---RWQHLLDLIAARVKKLKETLVAVQQL 7890
            + E K  ++N    RWQ +  L   R +KL + L  +++L
Sbjct: 5023 QSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062



 Score =  274 bits (701), Expect = 2e-72
 Identities = 711/3993 (17%), Positives = 1533/3993 (38%), Gaps = 498/3993 (12%)

Query: 4917 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4976
            L D++++     +  EE+  +  +   +S     + T  + L     +   ++L E    
Sbjct: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMS-----RLTPERNLDLERYQEKGSQLQERWHR 1258

Query: 4977 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--AQELLQLAGNGLDVESAEENLKS 5034
            +   L  RQ+ L  I      Y         W+E+  AQ+ +   G   D     E L  
Sbjct: 1259 VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQ 1318

Query: 5035 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5094
                F+  ++  + L++          ++K     D E ++ + +   +   +  G +  
Sbjct: 1319 QTALFAEIERNQTKLDQCQKFSQQYSTIVK-----DYELQLMTYKAFVESQQKSPGKRRR 1373

Query: 5095 LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS 5154
            +L    A   ++   R     L+  T + +   S        +A  +L E + +V     
Sbjct: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS--------DALRRLEEEEKVVEEEKQ 1425

Query: 5155 FH-EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5213
             H EK+  L    S L +  N   KAT S +  +     T +     +Q+ + E+   + 
Sbjct: 1426 EHVEKVKELLGWVSTLAR--NTQGKATSSETKES-----TDIEKAILEQQVLSEELTTKK 1478

Query: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE--YHDTFVLELEQQQSALGML 5271
               +  +K +   + +   KL  S  EK   +E L  L   YHD       Q Q     L
Sbjct: 1479 EQVSEAIKTSQIFLAKHGHKL--SEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536

Query: 5272 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5331
              QT          T  ++   +       +R L   +     G+  +Q+L   +  ++ 
Sbjct: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-----GRTTQQDLSALQKNQSD 1591

Query: 5332 INSVKCWVQETKEYLGNPTIEIDAQLEELQILLT--EATNHRQNIEKMAEEQKEKYLGLY 5389
            +  ++  +Q           +I+  +EE Q  L+  E T  R+ + +  E+        Y
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ--------Y 1643

Query: 5390 TILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLK 5449
              L  E   ++A+  L+  +   +Q   +E E+SKA     ++++ +  K +  +L  + 
Sbjct: 1644 EALQEET--RVAQKELEEAVTSALQ---QETEKSKA-----AKELAENKKKIDALLDWVT 1693

Query: 5450 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQ 5509
            +   +  Q  T+   + E+L G + +   LD     ++  N Q  + L K+   +   HQ
Sbjct: 1694 SVGSSGGQLLTNLPGM-EQLSGASLEKGALDTT-DGYMGVN-QAPEKLDKQCEMMKARHQ 1750

Query: 5510 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILH 5569
            + + Q +N +     A + L++                   HG                H
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQ-------------------HG----------------H 1775

Query: 5570 QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQD 5629
                EE + +  +L  + E  QY TS+  +E   +QV  L  E              LQ 
Sbjct: 1776 NLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQK 1819

Query: 5630 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV--- 5686
              +D K+FE+ L++ +  LE      +SPE     LK Q S  + ++S    L+      
Sbjct: 1820 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQ 5745
            Q V   +++ +  ++      L    L+   E     H+   +    +   + QY Q++ 
Sbjct: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939

Query: 5746 EMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK 5803
                LQ  ++     +E        S+   LQ Q++  ++L +++  +Q  +  L    +
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999

Query: 5804 MLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVMMTAGRCHTLLSPVTE 5862
                          + E+EG          E   +  +H  S+    A R   L   + +
Sbjct: 2000 -------------DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQ 2046

Query: 5863 -ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
             +S +E   S + S       +      +S++  +      +  +L+ D A+   S  A+
Sbjct: 2047 SQSVQESLESLLQSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT 2105

Query: 5922 QEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS 5974
            +E     +E   S TA     KL ++ + +E L     EK+ +L + L + + ++     
Sbjct: 2106 REMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH---- 2161

Query: 5975 ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE 6034
            +S K++      S     G  P+  +      + E+ +  ++  E   +L E LV+E   
Sbjct: 2162 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELSS 2220

Query: 6035 ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADE 6094
               A  L          +R+  +R   +  ++ ++E+  D    Q Q   L  +R     
Sbjct: 2221 CGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVRT 2271

Query: 6095 LDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN--- 6147
               WL  T+ ++     PP E      ++E Q+   +++L +   K   + E++      
Sbjct: 2272 FQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2326

Query: 6148 ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQGTAQEKEESDVDLTA 6206
            ENL++E    T  +++   G +    GS +      H  K L    T  + + SDV+L  
Sbjct: 2327 ENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL----TEIQCDMSDVNLKY 2379

Query: 6207 TQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRSVASRGEEILIQHSA- 6264
             +  GV             +RQ SLQ     +E+   E  S+L+ + S+ EE+L    A 
Sbjct: 2380 EKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQWLESK-EEVLKSMDAM 2427

Query: 6265 -----AETSGDAGEKPDVLSQELGMEGEK-------------SSAEDQMRMKWESLHQEF 6306
                  ET     E       EL     K             +    Q    W+ + +E 
Sbjct: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL 2487

Query: 6307 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 6366
            +++ +    V    Q Q+  S  +         +      +K  +  +L  L+     + 
Sbjct: 2488 NSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS-----ID 2542

Query: 6367 SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI 6426
                 A++Q +    K ++        L++  + +      +   T       + + +  
Sbjct: 2543 PNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKW 2602

Query: 6427 KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLDSVVNQRCHQMKERLQ 6484
             E++++++   +   QA  ++   +++++D    +  +G+   + S ++ +   +K++L+
Sbjct: 2603 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 2662

Query: 6485 QILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EAIQQAEDGLKEFDAGI 6540
            +    ++DL+ L   + + + +  +    + EQ + +++    E +     GL++  A  
Sbjct: 2663 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA-- 2720

Query: 6541 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
                   D++   Q ++    + Q M+DEL   +  ++S   +N  + ++ ER    L +
Sbjct: 2721 -------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQE 2773

Query: 6601 LLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQK 6658
              E  +   + +G  ++IV+  E +   +   +E             TL  +++      
Sbjct: 2774 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE-----------KRTLQNQLV------ 2816

Query: 6659 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLV 6718
            E + H E +++ +A                +  S L +  Q+  +    VE  +P +   
Sbjct: 2817 ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQKYQWHVEDLVPWIEDC 2860

Query: 6719 EENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKRLLISISCSD---LES 6767
            +     L   +D + L   L   K+ LNE + +  L ++L+    +LI+ S +D   +  
Sbjct: 2861 KAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD 2920

Query: 6768 QLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ--QS 6825
            +   + +   + T ++  +   LE + +    +Q    ++   ++ AK +LE +      
Sbjct: 2921 EKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ 2980

Query: 6826 VTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGNQLLRLKKVDTATLRS 6879
                + LE +R           +VD   +    ++      S  +QLL   +V       
Sbjct: 2981 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3040

Query: 6880 ELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV--IQKDEDNI 6937
               R++S           ++ KL  +       R   S++      ++ +  I +D D++
Sbjct: 3041 VKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3093

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
            ++ I  + +  +L K    K+DI   +     + +          E    D      +L 
Sbjct: 3094 QSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE----------EEGTLDLLGLKRELE 3141

Query: 6998 AMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 7057
            A+NK    L      + + LE  L    ++   ++ L       E+    Q  +G +  +
Sbjct: 3142 ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI 3201

Query: 7058 QNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKEDVSSIVMS-TLRELGQ 7109
             N     Q L D    ++++V+ ++      NGL   LIQ+  +D     +   + E+  
Sbjct: 3202 IN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256

Query: 7110 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7169
             W  L+  V Q    L+  L      + A + + S+L +    ++  +  +   + V+ Q
Sbjct: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQ 3316

Query: 7170 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7229
            +   + LQ  L+ ++ ++    +   ++ +       E +T  L+ +  RW  LL + A 
Sbjct: 3317 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3376

Query: 7230 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 7289
            + +  + +L L +++ + ++  +  +   E +        T       ++        D+
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436

Query: 7290 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 7349
                  V  ++    ++G+ L      +    +     SL      ++   C++   L  
Sbjct: 3437 ENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQ 3492

Query: 7350 GVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SDLSTIQERMEELKGQM 7400
             + +   F +    +  W+ E E+ L         QD  H   +D   + E +   K  +
Sbjct: 3493 ALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV 3552

Query: 7401 LKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT 7460
             +       L +    G  + L  +++  ++      ++ SS+      + +    + Q+
Sbjct: 3553 DQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611

Query: 7461 FLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELFQAEMFSRQQILHSII 7515
              E+   W+    + E++LA   SG      EQ     QR  EL + E+   + +L ++ 
Sbjct: 3612 TYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL-KKEVMEHRLVLDTVN 3665

Query: 7516 IDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKL 7575
               + LLE      R+  +  ++  + Q++ V     QR   ID+ I++ Q+Y + A+  
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE 3725

Query: 7576 RKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQGSYILTVEAGKQLLL 7633
              W+ E     M+ LG  PI L+Q +T    +VQ    +  +R + S         ++  
Sbjct: 3726 LAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG 3782

Query: 7634 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKDWEKCEKGIADSLEKL 7689
            +     +  LQ +   + +++++ S+   E+  +L      + + WE  E+ ++  +E+ 
Sbjct: 3783 TCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE-LSPWIEET 3841

Query: 7690 RTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI 7749
            R    +L     DH E+L  +Q   ++L  ++      + +L  +   L   ++ ++  +
Sbjct: 3842 RALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNPEEGEM 3899

Query: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKELCEWLTQMESKVSQN 7806
            + E+ +  +  + ++  ++  R   + E +++      F +K + + E L  + S++   
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959

Query: 7807 GDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAKASH----ESKASEIE 7856
               LI   ++K+++   + + A  +  K+Q     L++ GE L   S     +  A EI+
Sbjct: 3960 P--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4017

Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7916
             KL ++   W+ +      R  K  + L   ++   +M++L T +   +      IV+D 
Sbjct: 4018 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD-----IVHDL 4072

Query: 7917 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNL 7976
             +       + +Q E    I++ + G+   L    +L  D      + E   ++++   +
Sbjct: 4073 ESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 4132

Query: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK 8036
            +  W N+     ER  K+E+  +   ++ D      DWL ++          G      K
Sbjct: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192

Query: 8037 EELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLKQMVHEGNQRWDNLQK 8094
            ++L + + F+ +V++   ++E +N Q   + ++  + TD    +++ + E    W+NL +
Sbjct: 4193 DQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLTELKHLWENLGE 4251

Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD---VQAKIKQLKA 8151
            ++     +L+  +    +F+ A + ++ WLT  + +L + +     D   ++ ++ +   
Sbjct: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPKVIEVELAKHHV 4310

Query: 8152 FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--------------EELDELRRYCQ 8197
             + ++  +   +E +   G +L+E S   DA+ +               ++ +E  +  Q
Sbjct: 4311 LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ 4370

Query: 8198 EVFGRVERYHKK----LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8253
                + + +H +    L+ L   + +   S     L ++A    L  H      L + + 
Sbjct: 4371 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR-EQLDTHMELYSQLKAKEE 4429

Query: 8254 SSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 8309
            + N  L   + +   R    SG  T  SV  +  +W        + +S +  AL    E 
Sbjct: 4430 TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4489

Query: 8310 GQDDKDFY-------------------LRGAVGLSGDH-------SALESQIRQLGKALD 8343
                ++F                    L   +    +H       +A   QI +L +  +
Sbjct: 4490 QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 4549

Query: 8344 DSRFQIQQT----------------ENIIRSKTPTGPELDTSYK-------GYMKLLG-- 8378
              +F  Q+                 E +++     G  LD + K        + KL+   
Sbjct: 4550 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWL 4609

Query: 8379 -----------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI--------- 8418
                       E S+  D +K    K KE +++L G   ++ T  +T   +         
Sbjct: 4610 EDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 4669

Query: 8419 ------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQL 8466
                        D+W+ +  +++ ++ ++++ L    QF   L ++  WL   E +L + 
Sbjct: 4670 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAED 4729

Query: 8467 QRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 8526
            Q +    D+    +   K+   QK +  R   +  +     E  +    ++  ++ +L +
Sbjct: 4730 QPVHGDLDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 4787

Query: 8527 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLD 8584
            ++ RWD VC L    +  L+ AL Q + F +  H LL  L   ++  R    +P D+   
Sbjct: 4788 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA- 4846

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLK 8643
             + L D HK+ M+   ++ E ++ V S   M  ++++     DC+   K  + +I  R +
Sbjct: 4847 LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITIIRARFE 4902

Query: 8644 LLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8672
             +L    +H + LE  L   V++++  ++L +W
Sbjct: 4903 EVLTWAKQHQQRLETALSELVANAELLEELLAW 4935



 Score =  269 bits (688), Expect = 8e-71
 Identities = 836/4731 (17%), Positives = 1777/4731 (37%), Gaps = 681/4731 (14%)

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK--ML 1228
            +N  T   ETL  L+++   L E SS      Q   L K  S   A +  L+E E+  + 
Sbjct: 648  QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQS--LHKFVSRATAELIWLNEKEEEELA 705

Query: 1229 SNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAK 1288
             ++ D        +N   EL    +E Q+    + DT     A+ L L +    + + A 
Sbjct: 706  YDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT-----AELLSLENHPAKQTVEAY 760

Query: 1289 KRDVQQQIAQAQQ---------GEGGLPDRGHEELRKLESTLDGLERSRERQ-------- 1331
               VQ Q+   +Q          E     +   + R+LES L  L+ S +R+        
Sbjct: 761  SAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820

Query: 1332 ----ERRIQVTLRKWERFETNKETVVRYLFQTGS-------SHERFLSFS-SLESLSSEL 1379
                E  +Q ++ + E+   +K +V   + ++ +       S +  L  + S++++    
Sbjct: 821  LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYR 880

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEIPLG-------------PQNKQLLQQQAKSIKEQ 1426
            +      K  E +        K     P G             P NK  ++  ++  +  
Sbjct: 881  QIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY 940

Query: 1427 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1486
             K +    +  + T  ++   W++   + + +  W  EK +     E      ++Q    
Sbjct: 941  QKVMALWHQLHVNTKSLIS--WNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998

Query: 1487 KVTIQEIESKLSSIVG---LEEEAQS----FAQFVTTGESAR-----IKAKLTQIRRYGE 1534
                   +S L S+     LEEE ++    F   + + E+        K  +++++    
Sbjct: 999  DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRL 1058

Query: 1535 ELREHAQCLEGTILG----------------HLSQQQKFEENLRKIQQSVSEFEDKLAVP 1578
             L E+ Q +   I                   +++Q+  +E+L++++  +     K    
Sbjct: 1059 RLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF 1118

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED 1638
            +    S++    +  E   L + ++ +    T +    + V      +Q+A  L + YE 
Sbjct: 1119 LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEI 1178

Query: 1639 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1698
             L + +     L  L AHW  L   LS                          V+ +  +
Sbjct: 1179 KLSQEEVVLADLSALEAHWSTLRHWLSD-------------------------VKDKNSV 1213

Query: 1699 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP---QIINK 1755
               L  E+       +K++  + S  +     D++  +    QL ERW  +    +I   
Sbjct: 1214 FSVLDEEIAK-----AKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268

Query: 1756 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
             +  +Q V+ +++     L+    WI+      +TT++  +M              + E 
Sbjct: 1269 ELESIQEVLGDYRACHGTLIK---WIE------ETTAQQEMMK-----------PGQAED 1308

Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQ 1875
             +   + L    A    + R       Q K + C +  ++ S +V+  +L L     F++
Sbjct: 1309 SRVLSEQLSQQTALFAEIERN------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE 1362

Query: 1876 SHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY 1935
            S     G  R++  +           SD I ++  D      AL +        +S A  
Sbjct: 1363 SQQKSPGKRRRMLSS-----------SDAITQEFMDLRTRYTALVTLTTQHVKYISDALR 1411

Query: 1936 HLKIGSSEQRTSCRATADQLCGEVERIQNLLG-----TKQSEADALAVLKKAFQDQKEEL 1990
             L+    E+    +   ++    VE+++ LLG      + ++  A +   K   D ++ +
Sbjct: 1412 RLE----EEE---KVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464

Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDV 2050
            L+     EE T K   KE   +A++   ++F      L  H H+L    +K K+      
Sbjct: 1465 LEQQVLSEELTTK---KEQVSEAIKTS-QIF------LAKHGHKL---SEKEKK------ 1505

Query: 2051 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2110
                ++  ++N L   + D           C G  +   + Q L+S ++   E  +    
Sbjct: 1506 ----QISEQLNALNKAYHDL----------CDGSAN---QLQQLQSQLAHQTEQKTLQKQ 1548

Query: 2111 TRTTIKDQEDL-KWAF-SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
              T  +  EDL  W   ++   A ++    Q+DL           S L+K + SD   ++
Sbjct: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-----------SALQK-NQSDLKDLQ 1596

Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
             D+++    +  V + +E  M+  +  LS   ++ + R+++         Q  E    L 
Sbjct: 1597 DDIQNRATSFATVVKDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQ 1647

Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEH 2287
               R  +  KE E  V +   +  E      +L E  K ++   D +  + +   Q L +
Sbjct: 1648 EETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 1705

Query: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
               + +++  +L+     +T     +N       +  E L     ++ CE +K      +
Sbjct: 1706 LPGMEQLSGASLEKGALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQ 1750

Query: 2348 ELQSQQSN-ISSTQENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA--- 2401
            EL SQQ N I +TQ     L +  H+   E + + +   G +K+  + S   S+ +    
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810

Query: 2402 -SLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
             +LQ+ L+K F +  +EF+ W   ++   +         + L + L    +  + V   +
Sbjct: 1811 QTLQDELQK-FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869

Query: 2461 SKLDAVTQEGQTLY--------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2512
              L  VT  GQ +              +I + +++++  A E + A   +C +    L  
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 1929

Query: 2513 CASELGSFEDQHRKLNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2569
               +   F++    L  W+   E   E+  ++ +      + E+     +++  L E   
Sbjct: 1930 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQV 1989

Query: 2570 ARESLDKLSQRGQLLSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626
              E L K+++   ++  EG  A     +      +L+  Q+L     E+    Q A+ + 
Sbjct: 1990 PVEKLQKVAR--DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQS 2047

Query: 2627 EALEEALQSMWFWVKAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLN 2682
            ++++E+L+S+   +  ++  L   + S+L S   ++ L   +   QDI   K   E    
Sbjct: 2048 QSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATRE 2107

Query: 2683 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2742
            M      + + +++     V+Q +L  + + +  +       +S+L+ ++ Q   +    
Sbjct: 2108 MVT----RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163

Query: 2743 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE 2802
             +L+Q+ME+  + +    QP   +   F  +  L   + + +++   L  L+ +      
Sbjct: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGF 2223

Query: 2803 KTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEE 2862
              +    +D  Q  L+  F ++    KE+ +      +    +   V  F  WL   +  
Sbjct: 2224 ALDLCQHQDRVQN-LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2282

Query: 2863 LHRWSDMSGDSSATQKKLSKIKELIDS--------REIGASRLSR----VESLAPEVKQN 2910
            +   ++ S  +   +K++  +K L+D          EI     S     +E  AP+ +  
Sbjct: 2283 IPP-TETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGK 2341

Query: 2911 T-----------------------TASGCEL-------------MHTEMQALRA------ 2928
            T                       T   C++             +H   ++L+A      
Sbjct: 2342 TGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2401

Query: 2929 ----------DWKQWEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQAL 2969
                       W + ++ V ++   + +      V   A S + F  ++ Q    +++  
Sbjct: 2402 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2461

Query: 2970 EQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL------ 3023
            E  + LL T+         K   EE+   W +  E+  A Q+   + E+  S L      
Sbjct: 2462 EALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAA 2518

Query: 3024 -NELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVN 3082
             ++L  +  +     G +  L  + N L  Q     + + Q + + F    +  +Q    
Sbjct: 2519 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEA 2573

Query: 3083 AKITTAKCFDIPQNISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTL 3134
            A+       D+  + S+V   LQ I     E   +  +   +++  + K     ELL  L
Sbjct: 2574 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 2633

Query: 3135 LTKEKAKG----IQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VS 3181
              K +A G    +Q+ ++   E  K       +  S LE L  ++K+ +         + 
Sbjct: 2634 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 2693

Query: 3182 AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY------- 3226
             + ++D L K  + V      L DL A R  +        Q+ Q + +E+  +       
Sbjct: 2694 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753

Query: 3227 -------EPQLNRLKEKAQQLWEGQAA---------------------------SKSFRH 3252
                     +L RL+ + Q+  E Q +                            ++ ++
Sbjct: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813

Query: 3253 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3312
            ++ +L + +  LS  T ++ SRL   + +  ++   +++L  W+ D    + S    T D
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLD 2872

Query: 3313 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWAS 3372
               L+S  L+ +A+L+ + EK   +  I+     +L N+S       +     ++D  A 
Sbjct: 2873 PVQLESSLLRSKAMLN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAG 2924

Query: 3373 LLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKA 3432
            +         +L+            +R+F     ++E  + E  +   E+ D       +
Sbjct: 2925 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACS 2983

Query: 3433 KLLNEEVLSYSSLLETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQE 3478
                E++ +   +L+ +E +         G+ E      +   L       Q+ +  +++
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043

Query: 3479 RAKEAVTKSE-KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ- 3536
            R        E KL  + Q + R  + F   L    ++LD    +  D  + ++ + D++ 
Sbjct: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRL 3102

Query: 3537 ------ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
                   L++     +A    +L     +   G+     R LE+L +       R    +
Sbjct: 3103 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK----RELEALNKQCGKLTERGKARQ 3158

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWH-EEVT 3649
             Q    + ++    +K + +++    AEE  + +    +       QL   K +  E+V 
Sbjct: 3159 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3218

Query: 3650 AYRDEVEEVGARAQEILDESHVN---SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQS 3706
              + ++++V    Q ++  +  +     +     ++ +R+  L  +V ++I  L+E +  
Sbjct: 3219 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3278

Query: 3707 LEESESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSL 3763
              + + +L     W   T +   N K  + +   V   +  +KL  L+ LL D +    +
Sbjct: 3279 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDM 3336

Query: 3764 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3823
            L++   +G R  +  E  + E++  ++     +  EL S        LE  L LAK+F +
Sbjct: 3337 LQA---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393

Query: 3824 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3883
              + ++ +++  ++ L   E    +  + + Q+ ++K+L++ + +H   V    + G++L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453

Query: 3884 LELVQDV---TLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
              L        L +KID LQ+ Y ++          L+  + +   +  +  EV  WL +
Sbjct: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 3513

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 4000
            +  +L +   ++    + + +Q A H A+ EEI   +  ++     G  L+ Q       
Sbjct: 3514 VEDKLSSV-FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVL 3572

Query: 4001 KLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLE 4060
             +++     L G K  Y+ I  T+ +  ++LE   Q     Q T ++   WL  V+ +L 
Sbjct: 3573 LIQEK----LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 3628

Query: 4061 PSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQ 4120
             S      ++   +Q+  F+  Q++ +  +     + D  N   +   + +    +    
Sbjct: 3629 TSG----GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLD 3684

Query: 4121 KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK 4180
            KLV   N     E+ K +   +   + + D  +Q  ++     +  +A   V++ K  + 
Sbjct: 3685 KLVSDAN-----EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLM 3737

Query: 4181 -----KLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-E 4234
                 +L+  Q +    ++K   +          E+     +    C +     LQ + E
Sbjct: 3738 ALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 3797

Query: 4235 DLQRTRDYHDCMNV--------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQ 4286
             L +  +    +N          +V + +F   ++ L+    E+ A+ +  L   A+  +
Sbjct: 3798 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHE 3856

Query: 4287 ERKYAIEDLKDQKQKMIEH----------------LNLDDKELVKEQTSHLEQRWFQLED 4330
            + +   E+++  ++ + EH                LN ++ E+V+E+    E  + Q+++
Sbjct: 3857 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 3916

Query: 4331 LIKRK---IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNL 4383
             ++++   +  +V+   ++     + + ++E  E    N++  L+  P      D  +  
Sbjct: 3917 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIREC 3972

Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQ 4443
            + D+ +   ELE  Q   ++L +  + ++      ++ +  K + D    +    + +  
Sbjct: 3973 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA 4032

Query: 4444 RR-----KYLNKA-LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
            R      K+L+   L+EK  + MA    T  I+  +  +   E   + P  + +QV+  +
Sbjct: 4033 RAEEREIKFLDVLELAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090

Query: 4498 SAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQEL 4557
            + +        E+  +   G +L+    E EK EV   + E+ + ++++ +    RL++L
Sbjct: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150

Query: 4558 EKNLVSRKHFKEDFDKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSP 4613
            E  + +   +++       WL    I   T P +   +N   +   ++ +++  + +Q  
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4210

Query: 4614 EYENLLLTLQRTGQTILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILA 4672
            E E L       G+ +L  + +E D   + E L  L   +  +      + +K++ A+LA
Sbjct: 4211 EMEKL----NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266

Query: 4673 RKEYASLIE-----LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SLQ 4713
              ++   +E     LT T+ L +           +E +  +   +  D+   +A   ++ 
Sbjct: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326

Query: 4714 DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL 4773
                 +L+  AG     D+ +  +    +  Q W+        ++  + + + +Q  S L
Sbjct: 4327 KAGNELLESSAG-----DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQSTL 4373

Query: 4774 EDTTSAYQEHEKMCQQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGI 4830
            +     + E E    +L R   QL + K             +  +++Y  L    +    
Sbjct: 4374 QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQ 4433

Query: 4831 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4890
            +L +  + L       D  +  K    +   + +  +++S + E  ++ E  +  + +FQ
Sbjct: 4434 LLDKGRLML---LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4490

Query: 4891 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4950
              +   ++WL   +  L+      L L  +  +I + ++   EV +    +  L     +
Sbjct: 4491 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 4550

Query: 4951 -KFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWL 5009
             KF   K+ +       ++  S  +  +Q ++  R  +L +   + +++++ ++   DWL
Sbjct: 4551 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWL 4609

Query: 5010 EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKE 5069
            EDA                E +L S +E  +  D+    L +      TL       GK 
Sbjct: 4610 EDA----------------ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK- 4646

Query: 5070 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
               Q V    +R+ R  ++           T    D QK    +   + +   K      
Sbjct: 4647 ---QPVYDTTIRTGRALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVCG 4689

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
                  H+ EE L      +  + +  + +  +E + ++ +    D            V+
Sbjct: 4690 KSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF 4749

Query: 5190 Q-----RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASK 5244
            Q     R   ++ + +   +++E++ D+ T    ++++ +   D +  KL  S   +  +
Sbjct: 4750 QKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQ 4808

Query: 5245 AELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRC 5304
            A L     + DT  + LE    A     +QTL     GA P   E   L   I   ++  
Sbjct: 4809 A-LKQAEVFRDTVHMLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEFM 4858

Query: 5305 LNMQEK-VKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQIL 5363
              ++EK V  N  +   E+         I ++K W+          TI I A+ EE+   
Sbjct: 4859 KKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV--- 4904

Query: 5364 LTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQS 5423
            LT A  H+Q +E    E       L  +L     +Q AE  L  + ++ I   I  V+  
Sbjct: 4905 LTWAKQHQQRLETALSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKAL 4961

Query: 5424 KATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAV 5483
             A  Q    ++ +   D+  +    K K      A   +K       G    L +     
Sbjct: 4962 IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPP 5017

Query: 5484 QKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5534
               L Q+    +    +I +L+   QQ    A  R  KLN A   LEE  E
Sbjct: 5018 MPILSQS----EAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064



 Score =  266 bits (679), Expect = 9e-70
 Identities = 795/4586 (17%), Positives = 1743/4586 (38%), Gaps = 602/4586 (13%)

Query: 2207 DEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEE-LHSKVNDLKELT 2265
            D  E W    + +M E   +L   +   ELL +  ++++N AL  EE L    N L+   
Sbjct: 400  DVEEEWGKLII-EMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADA 458

Query: 2266 KNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2325
             +LE+   +Q  E+D++  ++  + +    +  L+    ++      + ++     ++++
Sbjct: 459  AHLESGQPVQ-CESDVIMYIQECEGLIRQLQVDLQILRDENYYQ---LEELAFRVMRLQD 514

Query: 2326 SLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL 2385
             L+   + E     +K      EL    S +++T      L +  HS+      + MT  
Sbjct: 515  ELVTL-RLECTNLYRKGHFTSLELVPP-STLTTTHLKAEPLTKATHSSSTSWFRKPMT-- 570

Query: 2386 IKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              + E V+   S+ + +L+   E   + E MQ              E ++   D   +E 
Sbjct: 571  --RAELVAISSSEDEGNLRFVYELLSWVEEMQ-----------MKLERAEWGNDLPSVEL 617

Query: 2445 KLHDLQNILDSVSD-GQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQC 2503
            +L   Q+I  SV + G S  +A   EG+     +S+   +S  E + K   ++    +  
Sbjct: 618  QLETQQHIHTSVEELGSSVKEARLYEGK-----MSQNFHTSYAETLGKLETQYCKLKETS 672

Query: 2504 LKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMF 2563
                + LQ     L  F  +     +W++E EE     +  ++  +I  K+N   ++ M 
Sbjct: 673  SFRMRHLQS----LHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTM- 727

Query: 2564 LGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVAL 2623
              EL   ++    L    +LLS E H A Q     S  +   Q+ L+  K+     +  +
Sbjct: 728  --ELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAV---QSQLQWMKQLCLCVEQHV 782

Query: 2624 QEHEA----------LEEALQSMWFWVK----------------AIQDRLACAESTLGSK 2657
            +E+ A          LE  L+++   +K                 +QD +   E  + SK
Sbjct: 783  KENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSK 842

Query: 2658 DTLEKRLSQIQDIL---------LMKGEGEVK-------LNMAIGKGEQALRSSNKE--- 2698
             ++   + + + I+         ++K    VK       + + I K ++ +   N +   
Sbjct: 843  SSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTK 902

Query: 2699 --------GQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQW-- 2748
                     + ++ +    +     D +  +   + + + V++ W+        L  W  
Sbjct: 903  WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962

Query: 2749 -MESVD----QKIEHPLQPQPGLKEKFV--LLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
              + +D      +E      PG   + +  L  H +  L ++ D       L + +  L 
Sbjct: 963  LRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSV-----LFSVADRLR 1017

Query: 2802 EKTEDESFKDTAQEELKTQFNDIM--TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSA 2859
             + E E+ K   Q  +K+  N+    TVAK  + +++ I      Y   V +    L S+
Sbjct: 1018 LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASS 1077

Query: 2860 KEELHRWSDMS---GDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
            + +   W D +    +   TQ+ L +++  +D+  +              + Q+ ++S  
Sbjct: 1078 RTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF---------LHQSPSSSSV 1128

Query: 2917 ELMHTEMQAL--RADWKQWEDSVF----QTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
              + +E+  L  + D      +V+    +T   +   +    L  + +  +++Q E  L 
Sbjct: 1129 PTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLA 1188

Query: 2971 QFSALLKTWA---QQLTLLEGKNT-----DEEIVEC---------------------WHK 3001
              SAL   W+     L+ ++ KN+     DEEI +                        K
Sbjct: 1189 DLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEK 1248

Query: 3002 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNK 3061
            G ++ +   +   + E  +S+L  +     D     G +   I+E          G    
Sbjct: 1249 GSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAED 1308

Query: 3062 EQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEV----STSLQKIQEFLSESENG 3117
             ++L ++  +    F + +   +    +C    Q  S +       L   + F+   +  
Sbjct: 1309 SRVLSEQLSQQTALFAE-IERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKS 1367

Query: 3118 QHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKD 3177
              K   MLS  + ++      + +   A VT   +  K     L + E   E  K+  ++
Sbjct: 1368 PGKRRRMLSSSDAITQEFMDLRTR-YTALVTLTTQHVKYISDALRRLE---EEEKVVEEE 1423

Query: 3178 FEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKE-- 3235
             +   E +++ L     +   +  +     ++ +E   ++  + E      +L   KE  
Sbjct: 1424 KQEHVEKVKELLGWVSTLARNTQGKA--TSSETKESTDIEKAILEQQVLSEELTTKKEQV 1481

Query: 3236 ----KAQQLWEGQAASKSFRHRVSQLSSQYLALS----NLTKEKVSRLDRIVA------- 3280
                K  Q++  +   K       Q+S Q  AL+    +L     ++L ++ +       
Sbjct: 1482 SEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTE 1541

Query: 3281 ------EHNQFSLGIKELQDWMTDAIHMLDSYCHPTS--DKSVLDSRTLKLEALLSVKQE 3332
                  + N     +++L  W+  A   L  +   T+  D S L      L+ L    Q 
Sbjct: 1542 QKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 1601

Query: 3333 KEIQMKMIVTRGESVLQNT----SPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE--- 3385
            +      +V   E  ++      SP  +  ++++L   K+ + +L       + +LE   
Sbjct: 1602 RATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 1661

Query: 3386 -GALSKWTSYQDGVRQFS----------GWMDSMEA-------NLNESER---------- 3417
              AL + T      ++ +           W+ S+ +       NL   E+          
Sbjct: 1662 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 1721

Query: 3418 -----------QHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT--E 3458
                       Q  E  DK   + KA+   LL+++   +L+  S    ++  G  +T  E
Sbjct: 1722 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781

Query: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3518
              + Q +L +L+E+Y     +++  + + + L    Q++ +D K FE WL + +++L+  
Sbjct: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841

Query: 3519 -----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQA 3567
                       S+L+      E  +    +L+     GQ +L+     +E   PS I   
Sbjct: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 1901

Query: 3568 EDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP--RT 3625
                L+   + + A   + +   +  N ++ +    +     +  W++  E  V      
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961

Query: 3626 RRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSRMGC 3677
               S+    + QL   K+  EE+  ++  VE++   A++I+        D  HV      
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE---- 2017

Query: 3678 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3737
                + S +Q+L   + E+   L++ I   +  + SL S     G   +N +    ++  
Sbjct: 2018 TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE--GKQVSS 2075

Query: 3738 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3797
            + + ++ + L T   L +D+ +  S L++ RE   R ++  +   A  L+ ++ +  ++ 
Sbjct: 2076 LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF 2135

Query: 3798 KELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLS 3857
            ++L    +++  +L+K L  A+ F      L Q++     +L    +P  ++     Q+ 
Sbjct: 2136 EQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQ 2195

Query: 3858 ----KYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEH 3913
                + +  Q+ + + E  V  +   G A L+L Q    +D++  L+ D+ +L    KE 
Sbjct: 2196 ELNLEMEDQQENLDTLEHLVTELSSCGFA-LDLCQH---QDRVQNLRKDFTELQKTVKER 2251

Query: 3914 VFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEI 3973
                 +  +  +++   ++  +KWL +  G +  P    + S + + +Q+ H K+++++ 
Sbjct: 2252 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKELEKQIEHLKSLLDDW 2309

Query: 3974 AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI------------- 4020
            A     +  +  KG +L     +      +    + L     S  ++             
Sbjct: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369

Query: 4021 --CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIK---- 4074
               S     Y+ L   L +   RQ++LQ     +  V  +     Q   S+ E +K    
Sbjct: 2370 CDMSDVNLKYEKLGGVLHE---RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDA 2426

Query: 4075 -----QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNL- 4128
                 + +  +A  E  + +L           A ++  +  IQ+ ++ +   LV   N  
Sbjct: 2427 MSSPTKTETVKAQAESNKAFL-----------AELEQNSPKIQKVKEALAGLLVTYPNSQ 2475

Query: 4129 -TQGWEEIKHLKSELW-----------IYLQDADQQLQNMKRRHSELE------------ 4164
              + W++I+   +  W             L+++   L   +   S+L             
Sbjct: 2476 EAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGV 2535

Query: 4165 ---LNIAQNMVS----QVKDFVKKLQSKQASVNTIIEKVNKL------TKKEESPEHKEI 4211
               L+I  NM++    QV+  +K+ ++++     + E    +           S   KE+
Sbjct: 2536 LGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 2595

Query: 4212 NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA--- 4268
              +N +W++L  + N+   Q ++ + ++  Y +   +++   EK       L+   A   
Sbjct: 2596 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE---LLQDLSEKVRAVGQRLSVQSAIST 2652

Query: 4269 --ESTAVHLEALKKLALALQERKYAIED---LKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4323
              E+    LE   ++   L++  + +++   L D+   +I    L D+   + +T  L  
Sbjct: 2653 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 2712

Query: 4324 RWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNL 4383
            +   LEDL   +I      L      Q  F EL  W +++Q   A+    S   +  Q+ 
Sbjct: 2713 Q--GLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770

Query: 4384 LMDHLAICSELEAKQMLLKSLIKDADRVMADLGL-NERQVIQKALSDAQSHVNCLSDLVG 4442
            L ++      L       + ++ + + ++  +    E++ +Q  L + ++H   LS    
Sbjct: 2771 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTA 2830

Query: 4443 QRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKS---- 4498
             R+  L   + +  ++   V      I+  + K M    + L P  +   +   K+    
Sbjct: 2831 DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAK-MSELRVTLDPVQLESSLLRSKAMLNE 2889

Query: 4499 --AQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKL----QELQSVYDSVLQKCSH 4552
               + SL    N    +     E  ++    EK+ +   +    +ELQ+   S L++ + 
Sbjct: 2890 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS-LEEMTQ 2948

Query: 4553 RLQE-------LEKNLVSRKHFKEDFD----KACHWLKQADIVTFPEINLMNESSELHTQ 4601
            RL+E       +EK +   KH  E FD    +AC   K  + +   +  L     ++   
Sbjct: 2949 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS-NKNLEKLRAQQEVLQALEPQVDYL 3007

Query: 4602 LAKYQNILEQSP---EYENLLLTLQRTGQTILPSLNEVDHS--YLSEKLNALPRQFNVIV 4656
                Q ++E +P   +   LL   +   Q  L     V+     +  KL  +  QF+  V
Sbjct: 3008 RNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI-GQFHCRV 3066

Query: 4657 ALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKV---PTDLAVEEALSLQ 4713
               ++ F ++ +         ++   T    S++E   L ++K+     D+   EA    
Sbjct: 3067 ---REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3119

Query: 4714 DGCRAILDE-----VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHL---VTLYHRLKRQ 4765
              CR +L+E     + GL   ++ LN++       G+  Q    L L      Y +LK  
Sbjct: 3120 -ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG- 3177

Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV----NEETLPAEEKLKMYHSL 4821
                   L D T+A +E E +   +  +++ + ++ +       E+  P + KL+  + L
Sbjct: 3178 -------LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGL 3230

Query: 4822 A-GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE 4880
              G +Q +G                      +   H ++        L   + + + + +
Sbjct: 3231 GQGLIQSAG-----------------KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273

Query: 4881 SRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRI 4940
              ++    FQ  +   L WL   +  ++         + ++ +I++ ++ Q  +      
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333

Query: 4941 MNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQR 4997
            ++ L   E  +  ++ EL  AD E    +L  L+    E L     RQ  L +I    ++
Sbjct: 3334 VDML-QAEGGRIAQSAEL--ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3390

Query: 4998 YYQVFQAANDWLE-DAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLV 5056
            +++  +  +D+L    ++L      G      ++ +  H    + E+   ++  ++H  V
Sbjct: 3391 FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHK---ALEEDIENHATDVHQAV 3447

Query: 5057 ---ATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEV 5113
                +L  L  P  +  L +K+ SL+ R   +      +  LL +  +    + +   EV
Sbjct: 3448 KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEV 3507

Query: 5114 IELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTG 5173
            +  + + E KLS    +K         + ++H AL       +E+IV  ++   Q  K G
Sbjct: 3508 LNWLAEVEDKLSSV-FVKDFKQDVLHRQHADHLAL-------NEEIVNRKKNVDQAIKNG 3559

Query: 5174 NDASKATLSRSMTTVWQ-------RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5226
                K T    +  + +       R+  +   +    + LE A    T F +  ++ T  
Sbjct: 3560 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 3619

Query: 5227 IDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPT 5286
            + +++++L  S  +  +  ++    +       E+ + +  L  + + + ++L+    P 
Sbjct: 3620 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLE--LVPW 3677

Query: 5287 PGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKE-- 5344
               E  L + ++   ++   + + +      +   ++  +  E   ++   WV ETK   
Sbjct: 3678 RARE-GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 3736

Query: 5345 -YLGNPTIEID---AQLEELQILLTEATNHRQNIEKMAEEQKEKY----LGLYTILPSEL 5396
              LG   +E D   AQL+  +    +   H+ +++++   + E +        T+L  + 
Sbjct: 3737 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 3796

Query: 5397 SLQLAEVALDLKIRDQIQDKIKE----VEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5452
               + +      +  +   +++     V Q   T +ELS  I++  + L   L       
Sbjct: 3797 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE-TRALIAQLPSPAIDH 3855

Query: 5453 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5512
            + + Q + + + L E +      + +L     +  E N + G+ + +K  K   ++ Q  
Sbjct: 3856 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK 3915

Query: 5513 RQAENRLSKLNQAAS---HLEEYNEMLELILKWIEK-AKVLAHGTIAWNSASQLREQYIL 5568
             +   R   L++A S    + E+++ +E +L+ +E  +  L    +      ++RE    
Sbjct: 3916 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 3975

Query: 5569 HQTLLEESKEIDSELEAMTEKLQYL-------TSVYCTEKMSQQVAELGRETEELRQMIK 5621
            +++   E +++    EA+  + + L             +++  ++ ++    E+++   +
Sbjct: 3976 NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4035

Query: 5622 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQ---ATLTSPEVGRLSLKEQLSHRQHLLSE 5678
             R     D  +  +KF  ++  L   ++  Q     L SP +    +K+Q+   + +  E
Sbjct: 4036 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4095

Query: 5679 MESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVV 5738
             + L  +++ +++  + L           +  +   +      L  T  ++   ++ A+ 
Sbjct: 4096 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4155

Query: 5739 QYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQI--A 5796
               QY+  ++ +   ++    ++   P   +++  ++ Q++  +E   K++ YQ+QI   
Sbjct: 4156 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQIEME 4213

Query: 5797 SLNSKCKMLTMKAKHAT----MLLTVTEV--------EGLAEGTEDLDGELLPTPSAHPS 5844
             LN + +++  KA   T    +   +TE+        E +A     L+G LL       +
Sbjct: 4214 KLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHA 4273

Query: 5845 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5904
            +  + +   HT          EE  +++           P++     +  ++A +  L  
Sbjct: 4274 LEELMSWLTHT----------EELLDAQ----------RPISGDPKVIEVELAKHHVLKN 4313

Query: 5905 ERLQTDAAKIHPSTSASQEFYEPGLEPSAT---AKLGDLQRSWETLKNVISEKQRTLYEA 5961
            + L    A +     A  E  E      A+   ++L  + + WE++     E+++ L   
Sbjct: 4314 DVL-AHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQST 4372

Query: 5962 LERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQDEIN 6018
            L++ Q +   ++    ++  +E +LS S   G  PE+   Q+  H  L  ++   ++  N
Sbjct: 4373 LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYN 4432

Query: 6019 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEE 6078
            +L       L+S     D       + ++ +L ++   +  K   ++  LEE LN   E 
Sbjct: 4433 QLLDKGRLMLLSRD---DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4489

Query: 6079 QRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
            Q   Q          E  +WL   + +L+ A SPP          +    +L +IE+  V
Sbjct: 4490 QNSLQ----------EFINWLTLAEQSLNIA-SPPS---------LILNTVLSQIEEHKV 4529

Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL--KGSLLELQRALHDKQLNMQGTAQE 6196
              +E++ H + ++         E +Q   +L+ L  K  ++ ++  L   Q   +   Q 
Sbjct: 4530 FANEVNAHRDQII---------ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580

Query: 6197 KEESDVDLTATQSPGVQEWLAQAR-TTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRG 6255
              E    L   +    Q   A  +   W +  +S L    + E E++     ++   S+ 
Sbjct: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL----DSELEISNDPDKIKLQLSKH 4636

Query: 6256 EEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED----QMRMKWESLHQEFSTKQK 6311
            +E        +   D   +     +E  +  E S   D    ++R KW+++  +   +Q 
Sbjct: 4637 KEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQH 4696

Query: 6312 LLQNVL--EQEQEQVLYSRPNRLLSGVPLYKGDVPTQ-DKSAVTSLLDGLNQAFEEVSSQ 6368
             L+  L    +    L +  + L    P    D P   D   V +L+D  ++ F++   +
Sbjct: 4697 KLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDA-HKVFQKELGK 4755

Query: 6369 SGGAKRQSIHLEQKLYDGVSATSTWL 6394
              G  +      ++L +     +TW+
Sbjct: 4756 RTGTVQVLKRSGRELIENSRDDTTWV 4781



 Score =  223 bits (568), Expect = 7e-57
 Identities = 733/3955 (18%), Positives = 1495/3955 (37%), Gaps = 630/3955 (15%)

Query: 4919 DIQEEIRKIQIHQEEVQSSLR-----------IMNALSHKE---KEKFTKAKELISADLE 4964
            D++EE  K+ I   E + SLR           I N + +     +EK T AK  + AD  
Sbjct: 400  DVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAA 459

Query: 4965 H-SLAELSELDGDIQEALRTRQATLTEIYSQCQ-----RYYQVFQAANDWLEDAQELLQL 5018
            H    +  + + D+   ++  +  + ++    Q      YYQ+ + A   +    EL+ L
Sbjct: 460  HLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTL 519

Query: 5019 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL 5078
                  +E      K H  F S E    S L   H     L      +      + +   
Sbjct: 520  R-----LECTNLYRKGH--FTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRA 572

Query: 5079 ELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND---TEKKLSEFSLLKTS-- 5133
            EL +   S D G    + +  +  W +  + + E  E  ND    E +L     + TS  
Sbjct: 573  ELVAISSSEDEGNLRFVYELLS--WVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE 630

Query: 5134 --SSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQR 5191
               S   E +L E K   +   S+ E +  LE +  +L++T +                 
Sbjct: 631  ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSS----------------- 673

Query: 5192 WTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5251
              R+R + Q   K +  A  E    N K ++  E+     D     SA++          
Sbjct: 674  -FRMRHL-QSLHKFVSRATAELIWLNEKEEE--ELAYDWSDNNSNISAKR---------- 719

Query: 5252 EYHDTFVLELEQQQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQ-EITAMQDRCLNMQ 5308
             Y     +ELE++Q     L+   + LS+    A  T       +Q ++  M+  CL ++
Sbjct: 720  NYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVE 779

Query: 5309 EKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEAT 5368
            + VK N     Q   D   +E+ + +++  ++  ++Y    + + +  L  L+ LL ++ 
Sbjct: 780  QHVKENTAYF-QFFSDARELESFLRNLQDSIK--RKY----SCDHNTSLSRLEDLLQDSM 832

Query: 5369 NHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQ 5428
            + ++ +     + K     L                               V +SK   Q
Sbjct: 833  DEKEQLI----QSKSSVASL-------------------------------VGRSKTIVQ 857

Query: 5429 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLE 5488
               R    + K+  ++      +   +   K D+ VL +       K++      +  + 
Sbjct: 858  LKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVIS-PTGNEAMVP 916

Query: 5489 QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEM---LELILKW-IE 5544
                L  P  K   ++    +Q+ ++      +L+     L  +N +   L+L+  W +E
Sbjct: 917  SVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLE 976

Query: 5545 KAKVLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS 5603
            K +  A G        Q+ +    H +  L++S+  DS L ++ ++L+    V   +   
Sbjct: 977  KLRSSAPG-----ECHQIMKNLQAHYEDFLQDSR--DSVLFSVADRLRLEEEVEACKARF 1029

Query: 5604 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL 5663
            Q + +     ++   + K+ +  L++    ++++E  + K   +L  ++    + +   L
Sbjct: 1030 QHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089

Query: 5664 SLKEQLSHRQHLLSEMESLKPKVQAVQL-CQSALRIPEDVVASLPLCHAALRLQEEASRL 5722
             + EQ    +H   +++ L+  + AV + C S L                   Q  +S  
Sbjct: 1090 RIAEQ----EHTQEDLQQLRSDLDAVSMKCDSFLH------------------QSPSSSS 1127

Query: 5723 QHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHE 5782
              T   + N++           ++M H+  L      +++   V   +IQ+ +  +  +E
Sbjct: 1128 VPTLRSELNLLV----------EKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYE 1177

Query: 5783 ELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH 5842
                 IK  QE++   +    +  ++A  +T+   +++V+        LD E+       
Sbjct: 1178 -----IKLSQEEVVLAD----LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVA 1228

Query: 5843 PSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQAL 5902
              +  +T  R   L     E   E+G+  +              +   S+ + +  Y+A 
Sbjct: 1229 EQMSRLTPERNLDL-----ERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283

Query: 5903 SAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEK---QRTLY 5959
                +     K    T+A QE  +PG    +                V+SE+   Q  L+
Sbjct: 1284 HGTLI-----KWIEETTAQQEMMKPGQAEDS---------------RVLSEQLSQQTALF 1323

Query: 5960 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 6019
              +ER Q   D  Q  S +   I           +  E Q+  ++A ++         ++
Sbjct: 1324 AEIERNQTKLDQCQKFSQQYSTIV----------KDYELQLMTYKAFVE---------SQ 1364

Query: 6020 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6079
             +S      +  S +A   E + L++  T L    +      S   + LEE      EE+
Sbjct: 1365 QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE------EEK 1418

Query: 6080 RQEQALQRYRCEADELDSWL--LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKV 6137
              E+  Q +  +  EL  W+  L+         S  KE  D+E  +++ Q +  E+  K 
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKK 1478

Query: 6138 VALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK 6197
              +SE ++    + L    H   E E+     +++   L  L +A HD            
Sbjct: 1479 EQVSE-AIKTSQIFLAKHGHKLSEKEK-----KQISEQLNALNKAYHDL----------- 1521

Query: 6198 EESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQ-QQKELEQELAEQKSLLRSVASRGE 6256
                 D +A Q   +Q  LA       Q  Q +LQ QQ    Q+L +    L S   + E
Sbjct: 1522 ----CDGSANQLQQLQSQLAH------QTEQKTLQKQQNTCHQQLED----LCSWVGQAE 1567

Query: 6257 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6316
              L  H    T  D       LS     + +    +D ++ +  S    F+T  K ++  
Sbjct: 1568 RALAGHQGRTTQQD-------LSALQKNQSDLKDLQDDIQNRATS----FATVVKDIEGF 1616

Query: 6317 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6376
            +E+ Q ++    P  L                   T+L + L+QA E+       A ++ 
Sbjct: 1617 MEENQTKL---SPREL-------------------TALREKLHQAKEQYE-----ALQEE 1649

Query: 6377 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6436
              + QK             ++EE +   T+ L +ETE     +   AK++ E  +++D  
Sbjct: 1650 TRVAQK-------------ELEEAV---TSALQQETE-----KSKAAKELAENKKKIDAL 1688

Query: 6437 KNLFSQAFPENGD---NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKER 6482
             +  +      G    N   +E   G  L  G L   D    VNQ       +C  MK R
Sbjct: 1689 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 1748

Query: 6483 LQQILNFQNDLKVLFTS----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
             Q++L+ Q +  +   S    L  + + +  +   + +Q + E  E   Q    L + +A
Sbjct: 1749 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEA 1805

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6598
             + +++   D+LQ     +Q+  + +   +     + +   G +   TL S  +R     
Sbjct: 1806 ELKQVQTLQDELQ---KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS 1862

Query: 6599 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQK 6658
             D++        GD + +  S    Q++LD    + +G E   I    L +  +  A ++
Sbjct: 1863 EDVISH-----KGDLRFVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATER 1912

Query: 6659 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--G 6716
             T  H+           +  + G  L  +L  +         L   ++  E+++  +   
Sbjct: 1913 YTALHS-----------KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961

Query: 6717 LVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-ISISCSDLESQLNQLGEC 6775
             V  +   L +++   + L+  L E+Q  + ++    + ++ I    +     + +  + 
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE-- 6833
             LS+   +S  L    ++L+            I   QS ++ LE   Q    V Q LE  
Sbjct: 2022 ILSHFQSLSYSLAERSSLLQK----------AIAQSQSVQESLESLLQSIGEVEQNLEGK 2071

Query: 6834 --------MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRID 6885
                    ++++ L   ++  +++  Q   KSS+ +T   + R  +   +T  + L    
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQG-- 2126

Query: 6886 SQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA 6945
                     +  V ++  QL + +     ++ +++    + E++  K +  ++N     A
Sbjct: 2127 --------KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2178

Query: 6946 --------IHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                    I  + Q+ +   +++  +Q  +D +   V ++SS           D  + L 
Sbjct: 2179 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL- 2237

Query: 6998 AMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 7057
               K +  LQ  V E+ +      E   E+   V+  + W +  E  +           +
Sbjct: 2238 --RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295

Query: 7058 QNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHM 7117
            +  ++  + L D   +K   VE+I   G +L         +++M       Q        
Sbjct: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSL--------ENLIMEITAPDSQ-------- 2339

Query: 7118 VGQLKILLKSVLDQWSSHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQV 7168
             G+   +L SV     S       +N Y     L E +  +S    ++  L G L   Q 
Sbjct: 2340 -GKTGSILPSVGSSVGS-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391

Query: 7169 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLE 7225
             +  + N  +++ K+  S+ ++     ++LK      + T T T+K   E N  +   LE
Sbjct: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451

Query: 7226 EIAEQLQSSKALL----------QLWQRYKDYSKQCASTVQQQED----RTNELLKAATN 7271
            + + ++Q  K  L          Q  + +K   ++  S  ++  +    R  +L ++A++
Sbjct: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511

Query: 7272 K---DIADDEVATWIQDCNDLLKGLGTV----------KDSLFFLHELGEQLKQQVD--- 7315
                  A+ ++  W+ +   ++  LG +          K  + F+ +  E  +QQ +   
Sbjct: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571

Query: 7316 -------------ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362
                         + + S +Q +  S++Q    L   L  + + +   ++    + + L+
Sbjct: 2572 EAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 2631

Query: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN-------- 7414
             L   +    + L  Q        S I  + E +K Q+ + S +  DL++L+        
Sbjct: 2632 DLSEKVRAVGQRLSVQ--------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 2683

Query: 7415 ---ELGYRLP---LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKC 7465
               EL   +    L D+  KR++ +      +     +R ++LQ+ L   Q F    ++ 
Sbjct: 2684 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 2743

Query: 7466 ETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL-EQ 7524
             TW++   Q++Q     IS   + L  Q + +E FQ  +         I+ +G+ LL   
Sbjct: 2744 RTWLDDK-QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 2802

Query: 7525 GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 7584
               +++     +L  L N W+ + ++   R+  +   +++ Q+Y+   E L  W +E   
Sbjct: 2803 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCK 2861

Query: 7585 LPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7644
              MS L     P+Q   +L        +V  R+  S +  + +   +L+++    E  ++
Sbjct: 2862 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIR 2919

Query: 7645 AELAEIQ-------EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS 7697
             E A I        E+ ++ +  LEE  ++L    + ++  EK +  +  +L  F    S
Sbjct: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 2979

Query: 7698 QSLPDHH-EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7756
            Q+  + + E+L A+Q   + LE  V  +  + TQ  L++D         D S L  + E+
Sbjct: 2980 QACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQ-GLVEDAPDG----SDASQLLHQAEV 3033

Query: 7757 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI------- 7809
             Q+++ E+  +++     +  +L     F  + +E+   L  ++ ++   G I       
Sbjct: 3034 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3093

Query: 7810 --------LIEEMIEKLKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHE 7849
                    L    I  LK D +   A     + +E        K +L+ + ++  K +  
Sbjct: 3094 QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTER 3153

Query: 7850 SKA--SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE 7907
             KA   ++E  LG+V D ++ L        K L +   A ++ +     + T +  I  +
Sbjct: 3154 GKARQEQLELTLGRVEDFYRKL--------KGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205

Query: 7908 LAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD 7967
            LA   ++     + +Q KL +   L + + + S G             DCD    + + +
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAG------------KDCDVQGLEHDME 3252

Query: 7968 SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 8027
             I       + RW  +     +R  +++E      KF D       WL  +E   A    
Sbjct: 3253 EI-------NARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKP 3305

Query: 8028 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQ 8087
                Y V K ++++ +  QR + +    ++++  +  R+A+         +   +     
Sbjct: 3306 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3365

Query: 8088 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAK 8145
            RW  L  +  +  ++L+  +   ++F    + I  +L+  + +L N E        +Q +
Sbjct: 3366 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3425

Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
            I + KA +++I  +   + Q +  G+ L   + P +  ++ E++D L+    E+  R  R
Sbjct: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485

Query: 8206 YHKKL------IRLPLPDDEHDLSDRELELED---SAALSDLHW---HDRSADSLLSPQP 8253
                L       RL   +DE ++ +   E+ED   S  + D      H + AD L   + 
Sbjct: 3486 KAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 3544

Query: 8254 SSNLSLSLAQPLRSERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 8311
              N   ++ Q +++ ++   + T   V  I  + D       D+    S+AL + ++  Q
Sbjct: 3545 IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604

Query: 8312 DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK 8371
                F           +  L   +R++ + L  S  Q    E I        P+     K
Sbjct: 3605 LATKF--------QSTYEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQK 3648

Query: 8372 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8431
               K + E    +D+V  +   L E    L  +      +   +   ++++L+      +
Sbjct: 3649 ELKKEVMEHRLVLDTVNEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQR 3704

Query: 8432 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8491
               +   +Q+ QQ+    ++  AW+ +T+ +L  L  + L  D  T +LQ++K   +   
Sbjct: 3705 VDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-I 3763

Query: 8492 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8551
            + H+ ++    +  S  F     ++   LQ++   +  +++ +  L  E    L+ A + 
Sbjct: 3764 IRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVL 3823

Query: 8552 CQGFHEMSHGLLLMLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVA 8610
               F E    L   +E     +  I  + S  +D E L+   +++ Q++  + E +  + 
Sbjct: 3824 VNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 3880

Query: 8611 SLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
             L  +  QL  +N E  + +E  EK     N    + +EV +    L++ +  S+
Sbjct: 3881 KLLKIGPQLKELNPEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 3933



 Score =  218 bits (556), Expect = 2e-55
 Identities = 155/450 (34%), Positives = 233/450 (51%), Gaps = 70/450 (15%)

Query: 20  RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
           R+ DE++ VQK+TFTKW+N HL K +    ++DL+ED++DG  L++LLEVLSG KLP E+
Sbjct: 71  RVADERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREK 128

Query: 80  GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
           GR   R H + N+  AL FL+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++ 
Sbjct: 129 GRM--RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI- 185

Query: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
                              +S E+    +K K            LL W Q      TGI+
Sbjct: 186 ------------------YISGESGDMSAKEK------------LLLWTQKVTAGYTGIK 215

Query: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
             +F   W  G  F+++IH  RP+LVD+E V+ +SNRENLE AF +AE  LG+ RLLD E
Sbjct: 216 CTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAE-RLGVTRLLDAE 274

Query: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
           DVDV  PDEKS++TYV+     +P +     +G    E+   +  + + V +        
Sbjct: 275 DVDVPSPDEKSVITYVSSIYDAFPKVPEGG-EGISATEVDSRWQEYQSRVDS-------- 325

Query: 320 FKEMKVWIEQFERDLTRAQMVESNLQDK--YQSFKHFR----VQYEMKRKQIEHLIQPLH 373
              +  WI+Q    ++     ++ ++ K  Y  + HF+    +  E ++ +IE L + L 
Sbjct: 326 ---LIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLE 382

Query: 374 ---RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSL-PAPLGTIGAWLYRAEVALREEI 429
                G++ L Q       +    +L    ++ +KSL PA        + R E+ L+   
Sbjct: 383 VWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPA--------VERLELLLQIAN 434

Query: 430 TVQQVHEETANTIQRKLEQHKDLLQNTDAH 459
            +Q      A   + KL   K+ LQ   AH
Sbjct: 435 KIQ----NGALNCEEKLTLAKNTLQADAAH 460



 Score =  199 bits (505), Expect = 1e-49
 Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)

Query: 503  MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
            +++LE K  +L  +    S  K+        E+V+   ++  +F+      EQ     Q 
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2459

Query: 563  LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 622
            +K+     +    + +EAEN  K   E  ++W   +    + +  LEE  S+   +    
Sbjct: 2460 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 2519

Query: 623  ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 669
            + L+ WL + E              MLN  +   +   +      QQH  +N+A   ++ 
Sbjct: 2520 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579

Query: 670  TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 726
               +  + +  ++++L  +N +W EL  ++  + +Q D+      +Y + +  LS     
Sbjct: 2580 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 2639

Query: 727  AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 780
              ++LS    +S     VK  +++  +I   +  +D + K    +  + + LI ++  ++
Sbjct: 2640 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 2699

Query: 781  EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
            E K+   T    +  L++            L  +QQ     +EL   +        K   
Sbjct: 2700 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 2759

Query: 837  IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
            I   LER  QS     ++ Q+ L   ++      ++ +G         L +V    ++  
Sbjct: 2760 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 2810

Query: 897  LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 954
            LQ Q+ ++   ++ + KKT D +  ++   +  +K++    +L   +   +  + E    
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870

Query: 955  -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1007
             DP +L   L R     +++++R   + L+  +   DIL    E ++ G+++    +++ 
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928

Query: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
               +  E       L+   E  + L   +E    ++++      EG+    K     F  
Sbjct: 2929 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 2976

Query: 1068 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1103
             G      K L+ +      L   +P            V D P                 
Sbjct: 2977 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3036

Query: 1104 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1163
               E++  ++S    +    +    +  R  E  S ++  + +L G+     DT     +
Sbjct: 3037 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3093

Query: 1164 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1223
            +  +E++R         L   K  +  L   +SE E +   +E   L      L+ L  E
Sbjct: 3094 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3139

Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1275
            +E +    G   +  +  +  LE  +   ++   + + + D     E  + L        
Sbjct: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199

Query: 1276 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1322
             + +QQ       +K  V     + QQ    G+G +   G +        ++ ++ +  +
Sbjct: 3200 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3259

Query: 1323 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1380
             L +   ++  ++Q  L    +F+   E ++ +L  T    ++++  S +  + + ++++
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3318

Query: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1438
            + K   +  +      + L  E   I    +  +++ +  Q +S++ +  +L        
Sbjct: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378

Query: 1439 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1495
            K +E +      F    E +S +++  EK+L   E   T ++ +  QI + K   ++IE+
Sbjct: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438

Query: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1554
              + +    +  QS +   +  E   +  K+  ++    E+++   C +  +L   LS  
Sbjct: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3497

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1610
            + F E+  ++   ++E EDKL+            ++   +H+ L + +    +++  AI 
Sbjct: 3498 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 3557

Query: 1611 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1665
               A  ++    +  +  ++   ++ +Y DI   + +    LE    L   +Q   +EL+
Sbjct: 3558 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 3617

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
             +L  +E  E  A+S     + +++    + Q  + L+ EV+        + ++  +L  
Sbjct: 3618 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 3673

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1781
            +      + +   +   +E+++ +   I +R++ + + +   QQ+++   +   W+    
Sbjct: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 3733

Query: 1782 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1833
                    + L + QTT+++ +     + + RHKD   E+ S + E+          G+ 
Sbjct: 3734 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 3784

Query: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1889
            G  E   +LQ K E   Q +E  S +   R   L      + +F +++  LS  + + R 
Sbjct: 3785 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843

Query: 1890 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1947
             +    S   +   L ++   +  Q  +++      +D +L        L     E    
Sbjct: 3844 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902

Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
                A+ +  +++           EA + +     F D+ E +L+++E++  R     L 
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962

Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2061
                  +++ +        EL   +     LK + +++      A KD+A A E+  +++
Sbjct: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4021

Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2120
            ++   W+D K    E + +   +++L  ++    +A+   +++   ++    +   D   
Sbjct: 4022 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4081

Query: 2121 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2180
            +K      ET K + +   ++L+     G  L+    +    +   V+  ++   + W +
Sbjct: 4082 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4138

Query: 2181 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2234
            +++  +E +++L  ++        T   +  W +N V      P +  +++ + + L   
Sbjct: 4139 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4197

Query: 2235 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2287
              +KEF+ EV  + + +E+L+        K  D  +     E   +L+ +  +L +K+ H
Sbjct: 4198 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4255

Query: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2342
             +   E A   L  F       +  + ++ +W T  EE L     ++         L K 
Sbjct: 4256 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4308

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
              ++ ++ + Q+ + +  +  N L       +  SL   +  + +  E+V Q   + +  
Sbjct: 4309 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368

Query: 2403 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
            LQ +L+  + F   +++F       ++    S    G  +    +L     +   +   +
Sbjct: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4428

Query: 2461 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2519
               + +  +G+  L +       S  ++ +    +++     +  + K  L++  +    
Sbjct: 4429 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4488

Query: 2520 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
            F++  ++   W+   E+  N  +      +    + E HKV  F  E+ A R+ + +L Q
Sbjct: 4489 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 4546

Query: 2580 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2632
             G   + LS++     Q+  L   LL S Q+    +++ + E+ RS   A +  +   EA
Sbjct: 4547 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 4601

Query: 2633 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2692
             + +  W++  +  L          D ++ +LS+ ++     G  +   +  I  G +AL
Sbjct: 4602 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 4660

Query: 2693 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
            +      E  + +   L  +++ W  +   SV  Q  LE  +     +++    L  W+ 
Sbjct: 4661 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 4720

Query: 2751 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2810
             V+ ++         L     L+D  +    E    T  +  L    REL E + D++  
Sbjct: 4721 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 4780

Query: 2811 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
               Q +EL T+++ +  ++  K  ++E+ +K   ++ D VH   +WL  A++ L     +
Sbjct: 4781 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 4840

Query: 2870 SGDSSATQKKLSKIKELIDSRE 2891
              D+ A Q  +   KE +   E
Sbjct: 4841 PDDTEALQSLIDTHKEFMKKVE 4862



 Score =  154 bits (389), Expect = 4e-36
 Identities = 445/2581 (17%), Positives = 976/2581 (37%), Gaps = 297/2581 (11%)

Query: 344  LQDKYQSFKHFRVQYEMKRKQIEHLIQP----LHRDGKLSLDQALVK-------QSWDRV 392
            L  + Q  +    ++E +R+Q E L +     L   G +SL  + V+       Q W  +
Sbjct: 2546 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 2605

Query: 393  TSRLFDWHIQLDKSL--PAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHK 450
            T +L     Q+D+++        +   L     A+ + ++VQ         ++++LE+  
Sbjct: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665

Query: 451  DLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKY 510
            ++  + +       E         + +    L+D  ++      T  L L  +E L    
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR---LETVALPLQGLEDLAADR 2722

Query: 511  --RLLSLLVLAES------KLKSWIIKYGRRES--------VEQLLQNYVSFIENSKFFE 554
              RL + L   +       +L++W+     +++        +E+L        E  K   
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782

Query: 555  QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 614
            Q+  +Y+++    E  + +    EE   +   + E    W  LS +    +S L++ +  
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842

Query: 615  WDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEM 674
              +Y   V  L  W+ED +        AK    R     +Q  +++  +   L E     
Sbjct: 2843 AQKYQWHVEDLVPWIEDCK--------AKMSELRVTLDPVQLESSLLRSKAMLNEV---- 2890

Query: 675  VSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEP 734
               + ++ LL +     ++ +     ++ADE D ++ E       + A   E   K    
Sbjct: 2891 ---EKRRSLLEILNSAADILI---NSSEADE-DGIRDEKAGINQNMDAVTEELQAKTG-- 2941

Query: 735  LEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKE 794
                          LE++ QR+      +K I K           E  K        L  
Sbjct: 2942 -------------SLEEMTQRLREFQESFKNIEKKV---------EGAKHQLEIFDALGS 2979

Query: 795  QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQ- 853
            Q    K      L   Q++L  LE     + +F   L      +      + +S L  Q 
Sbjct: 2980 QACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGL------VEDAPDGSDASQLLHQA 3031

Query: 854  --KHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSM 911
                QE L  ++       ++E   + + +F        H     +  Q+AD+      M
Sbjct: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQF--------HCRVREMFSQLADLDDELDGM 3083

Query: 912  ---VKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
                + T   +  +E     + K    + ++E      +  LEE+G  + L  +      
Sbjct: 3084 GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK------ 3137

Query: 969  QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEK 1028
                R L A  K C +LT+   +  Q+ L+  + ++   ++ L+G     L       E+
Sbjct: 3138 ----RELEALNKQCGKLTE-RGKARQEQLELTLGRVEDFYRKLKG-----LNDATTAAEE 3187

Query: 1029 NRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKL 1088
               L  V     E+     +  Q    K+ ++ +V      P  +  +++  + +  ++ 
Sbjct: 3188 AEALQWVVGTEVEI-----INQQLADFKMFQKEQV-----DPLQMKLQQVNGLGQGLIQS 3237

Query: 1089 PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS-------SWIS 1141
              +D   D  G  H  ++E+ A  ++  +K+ +   + ++      +F        SW++
Sbjct: 3238 AGKD--CDVQGLEH-DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294

Query: 1142 TNETQLKGIKGEAIDTANHGEVKRAVEE---IRNGVTKRGETLSWLKSRLKVLTEVSSEN 1198
              E   + I  +   +A +  VK  ++E   ++  +  R  T+  L++    + + +   
Sbjct: 3295 DTE---ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351

Query: 1199 EAQKQGDELAKLSSSFKALVTLLSEVEKMLSN-------FGDCVQYKEIVKNSLEELISG 1251
            + +K   +L  L S +  L++  +  +K L +       F +  +      +  E+ ++ 
Sbjct: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3411

Query: 1252 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQ--QIAQAQQGEGGLPDR 1309
            S+ V  Q  KI         QQ ++ H+   + I     DV Q  +I Q+        ++
Sbjct: 3412 SEPVGTQTAKI---------QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3462

Query: 1310 G--HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL 1367
            G   E++  L++    ++    R+   +   L     F  ++  V+ +L +     E  L
Sbjct: 3463 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV----EDKL 3518

Query: 1368 SFSSLESLSSEL--EQTKEFSKRTESIAVQAENL---VKEASEIPLGPQNKQ--LLQQQA 1420
            S   ++    ++   Q  +     E I  + +N+   +K    +      ++  L+Q++ 
Sbjct: 3519 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578

Query: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
              IK +   +  T  + ++T+E  +     F S +E L+ W+ E E+EL A     S   
Sbjct: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL-ATSGGQSPTG 3637

Query: 1481 MQISQIKVTIQEIESKLSS----IVGLEEEAQSFAQFV----TTGESARIKAKLTQIRRY 1532
             QI Q +   +E++ ++      +  + E +++  + V      G    +     Q +  
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697

Query: 1533 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV--PIKICSSATETYK 1590
             + + +    ++  I     + Q++E+        V+E + KL    PI++    T    
Sbjct: 3698 SDTIGQRVDEIDAAI----QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 3753

Query: 1591 VLQE--------HMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRR 1642
             +Q+        H D    L S  S I       +K V +    ++  +L QQYE I   
Sbjct: 3754 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ----EKTESLIQQYEAISLL 3809

Query: 1643 AKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA-DRVKVEGELQLIQA 1701
              ER   LE       +  +       W+E  E +A   ++   A D  ++  + + ++ 
Sbjct: 3810 NSERYARLERAQVLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQ 3867

Query: 1702 LQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
            L+  +        KLL++   L  + + ++ +M++   ++ +  +  + + + +R   L 
Sbjct: 3868 LRESIAEHKPHIDKLLKIGPQLKEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926

Query: 1762 SVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV---------ALTRHKDHAAE 1812
              V++  Q  E    F   I+  L  L+  S    M   +          ++ +K    E
Sbjct: 3927 EAVSQSTQITE----FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE 3982

Query: 1813 VESKKGELQSLQGHLAKLGSLGRAEDLHL----LQGKAEDCFQLFEEASQVVERRQLALS 1868
            +E  +   ++L+    +L    +  D  L    +Q K +     +E+     E R++   
Sbjct: 3983 LEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042

Query: 1869 HLAEFLQSH-ASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1927
             + E  +     ++ +L  ++ T +  + +   ES  I+  +    Q  +A E+     D
Sbjct: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDL---ESPGIDPSI--IKQQVEAAETIKEETD 4097

Query: 1928 GILSKAQYHLKIGS-------SEQRTSCRATADQLCGE--------VERIQNLLGTKQSE 1972
            G+  + ++   +G+         ++   R + D++            ER++ L    Q+ 
Sbjct: 4098 GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAA 4157

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVF-NQLEDELNSH 2031
                  L+  F      ++K        TD   +K+   +  + ++ V+  Q+E E  +H
Sbjct: 4158 VQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNH 4217

Query: 2032 EHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2091
            + EL  +  KA     +D+   P     +  L+  W++    I   Q +  G +  + ++
Sbjct: 4218 QGEL--MLKKATDETDRDIIREP-----LTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270

Query: 2092 QNLKSAVSKVLENASSVIVTRTTIK-DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGK 2150
            Q+    +   L +   ++  +  I  D + ++   +KH   KN +   Q  ++     G 
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330

Query: 2151 HLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE 2210
             L   L+     D S +++ +E+    W  V +K EE   +L+          ST  + +
Sbjct: 4331 EL---LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ----------STLQQAQ 4377

Query: 2211 GWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLET 2270
            G+ +     + E ++ +++ L A +         + +     EL+S++   +E    L  
Sbjct: 4378 GFHSEIEDFLLE-LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLD 4436

Query: 2271 PPDLQFIEAD--------------LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2316
               L  +  D              L QK        E  K  L++    +T+ +  + + 
Sbjct: 4437 KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496

Query: 2317 TTWFTKVEESLMNCAQ------NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
              W T  E+SL N A       N     +++ K    E+ + +  I    +  N L    
Sbjct: 4497 INWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555

Query: 2371 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWFLGAKAA 2428
               ++  +   +  +  + E V Q   +   SL ++ +  K F E+ ++  +W   A++ 
Sbjct: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH 4615

Query: 2429 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAH-LSKQIVSSIQE 2487
                 + + D   ++ +L   +    ++   Q   D   + G+ L    L  +    +  
Sbjct: 4616 LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN 4675

Query: 2488 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2547
             + +  +++     + ++ +  L++     G F D  + L  W++++E +   +      
Sbjct: 4676 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 4735

Query: 2548 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHG--AGQEGRLCSQLLTSH 2605
              +     + HKV  F  EL     ++  L + G+ L E         +G+L  +L T  
Sbjct: 4736 LDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRW 4792

Query: 2606 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLS 2665
              + +++  K    + AL++ E   + +  +  W+   +  L    +     + L+  + 
Sbjct: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 4852

Query: 2666 QIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQ 2725
              ++ +    E  V +N A+  GE  L   + +    I+  +  ++  + ++++ +   Q
Sbjct: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912

Query: 2726 STLESVISQWNDYVERKNQLEQWME----SVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2781
              LE+ +S+     E   +L  W++    ++ Q+ + P+ PQ   + K ++ +H Q+ + 
Sbjct: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI-PQNIDRVKALIAEH-QTFME 4970

Query: 2782 E 2782
            E
Sbjct: 4971 E 4971



 Score =  128 bits (322), Expect = 2e-28
 Identities = 348/1922 (18%), Positives = 741/1922 (38%), Gaps = 191/1922 (9%)

Query: 481  QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 538
            Q   + ER        EL L ++E    K + L+    A  E++   W++     E + Q
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3204

Query: 539  LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 598
             L ++  F +     +  ++  Q +    +  +++ G   + + +   M E  A+W  L+
Sbjct: 3205 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3262

Query: 599  VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF---------RN 649
             +V    + L+E + +  ++ + +  L +WL D E+++   +    ++          + 
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322

Query: 650  LPHWIQQHTAMNDA----GNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVK-QYAQAD 704
            L   +    A  D     G  + ++ +      +  QL  L  RW EL  +   +  Q +
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382

Query: 705  EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 758
            ++  + K++ +    +S F +   KKL+    V     K+  Q +      EDIE     
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442

Query: 759  MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 816
            +    KI    + L    SP E+G  +   +  L+ + +++++  C    L +  Q L  
Sbjct: 3443 VHQAVKIGQSLSSLT---SPAEQGV-LSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3496

Query: 817  LEELEKQMTSFYDSLGKINE-IITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 872
                 +      + L ++ + + +V  ++ +   L +Q H + LA  E   N KK +   
Sbjct: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 3555

Query: 873  EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 932
             K  Q++ K  T   VL       +Q ++  I   +  +   +    + +E   +L  KF
Sbjct: 3556 IKNGQALLKQTTGEEVLL------IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 3609

Query: 933  EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 983
            + +  EL   LR  +E L   G          +  +R  E   ++ +   VL+   +   
Sbjct: 3610 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 3669

Query: 984  ELTDILPEQEQQGLQEAVRKLHKQWK---------------DLQGEAPYHLL---HLKID 1025
             L +++P + ++GL + V   ++Q+K                +Q    Y       L   
Sbjct: 3670 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729

Query: 1026 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1078
             E  R L ++   R E D+ T +L  Q+     I  H+    +   H       C E++ 
Sbjct: 3730 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 3789

Query: 1079 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST-YRKLMEDPDKWKDYTSRFSEFS 1137
             +++E    L              +   E  + ++S  Y +L         +   + E S
Sbjct: 3790 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835

Query: 1138 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1196
             WI      +  +   AID   H ++++  EE+R       E    +   LK+  ++   
Sbjct: 3836 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892

Query: 1197 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1248
                    E + QK  +  A++    +     L E     +   +     E +  +LE L
Sbjct: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952

Query: 1249 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
             S  +    +  + +KI   E + + +   +  ++      A KR  ++ I ++Q  +  
Sbjct: 3953 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4010

Query: 1306 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1354
            L  +   ++L ++    + ++   E +E +    L   E+F         T K+T  +V 
Sbjct: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4070

Query: 1355 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1414
             L   G   +  +    +E+  +  E+T    +  E I +   +L+    E       K 
Sbjct: 4071 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128

Query: 1415 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1468
            +       +   K+ KE+++KLED ++  ++  + ++  +D   +    L          
Sbjct: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4180

Query: 1469 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1526
            +  + T  + +  Q++++K    E+  +   +  L  + +   +   T E+ R  I+  L
Sbjct: 4181 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4239

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
            T+++   E L E     +  + G L    +F+  L ++   ++  E+ L     I     
Sbjct: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299

Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1640
                 L +H  L   + +  + +   + +  +++      +  S      A+ Q +E +L
Sbjct: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359

Query: 1641 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1700
            ++ +ER+  L++ L   Q    E+  FL  L R E++ S+ +          E +L    
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4418

Query: 1701 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1757
             L +++ ++   Y++LL   +    + S+DD       +  +  L+++W  +   + +R 
Sbjct: 4419 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476

Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1815
            + L+  +    +F   L  F  W+ L    L   S  S++ + V   +  HK  A EV +
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536

Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1871
             + ++  L     +L  L + +D+ L++         +E+  Q  +ER R L  A     
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596

Query: 1872 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1931
            +F ++   L   L      +++   ++ N+ D I+  L+   +  K L       D  + 
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655

Query: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1987
              +  LK  +     S +   D   GEV ++   + G    +Q + +   +    F D  
Sbjct: 4656 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712

Query: 1988 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2047
            + L+  +  +E +  +++        +   +      + EL      +  LK   +++ +
Sbjct: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772

Query: 2048 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
                    V  ++  L   WD   +L    Q +    +     +++    + + L  A  
Sbjct: 4773 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832

Query: 2108 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2166
             +  R  + D  E L+     H+    K+  K+ D+++  + G+ +L+     H    + 
Sbjct: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 4889

Query: 2167 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2222
            +K  +     ++ +V    +++  RL  +LS         +E+  W        + +  E
Sbjct: 4890 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949

Query: 2223 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2276
             I  N+D   R + L+ E ++        +EE+  K  D+  +T     KN+E P    F
Sbjct: 4950 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 4998

Query: 2277 IE 2278
            IE
Sbjct: 4999 IE 5000



 Score =  117 bits (293), Expect = 5e-25
 Identities = 399/2277 (17%), Positives = 882/2277 (38%), Gaps = 342/2277 (15%)

Query: 6587 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLL------DKH----KEYFQG 6636
            L++ YE  LQD  D +          ++ + + K   Q L+      DK     K Y   
Sbjct: 993  LQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE 1052

Query: 6637 LESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDE 6696
            L++  +  E   ++++   +Q      T+  A     L+ A +             H  E
Sbjct: 1053 LKNIRLRLEEYEQRVVK-RIQSLASSRTDRDAWQDNALRIAEQE------------HTQE 1099

Query: 6697 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6756
            D Q+L   L+ V     S      +   +         L+S LN    K+  V       
Sbjct: 1100 DLQQLRSDLDAVSMKCDSFLHQSPSSSSV-------PTLRSELNLLVEKMDHVYGLSTVY 1152

Query: 6757 LISISCSDLESQLNQLGECWLSNTN-KMSKELHRLETILKHWTRYQSESADLIHWLQSAK 6815
            L  +   D+  +  Q  E  +     K+S+E    E +L   +  ++  + L HWL   K
Sbjct: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQE----EVVLADLSALEAHWSTLRHWLSDVK 1208

Query: 6816 DRLEFWT--------------QQSVTVPQ---ELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
            D+   ++              Q S   P+   +LE  ++  +   E    V AQ  ++ S
Sbjct: 1209 DKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268

Query: 6859 VLSTGNQLLR---------LKKVDTATLRSE------------LSRIDSQWTDLLTNIPA 6897
             L +  ++L          +K ++  T + E            LS   SQ T L   I  
Sbjct: 1269 ELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER 1328

Query: 6898 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFK 6957
             Q KL Q Q                 S   + I KD +     + YKA  E  QK  G +
Sbjct: 1329 NQTKLDQCQK---------------FSQQYSTIVKDYE--LQLMTYKAFVESQQKSPGKR 1371

Query: 6958 IDI--NCKQLTVDFVN-----QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 7010
              +  +   +T +F++      +++ +++Q V+         ++ L  + +  ++++   
Sbjct: 1372 RRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKY-------ISDALRRLEEEEKVVEEEK 1424

Query: 7011 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 7070
             E ++ ++ LL   S    N Q   T  ET+E              ++ A+ + Q L + 
Sbjct: 1425 QEHVEKVKELLGWVSTLARNTQGKATSSETKES-----------TDIEKAILEQQVLSEE 1473

Query: 7071 IKAKEKEVEK--------IEQNGLALIQNKKEDVSS-----------IVMSTLRELGQTW 7111
            +  K+++V +        + ++G  L + +K+ +S            +   +  +L Q  
Sbjct: 1474 LTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ 1533

Query: 7112 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQ 7169
            + L H   Q     K++  Q ++     + + S++ +A  +L+  + R     L A+Q  
Sbjct: 1534 SQLAHQTEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN 1588

Query: 7170 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7229
              +L++LQDD++ +  S           ++E    ++      L+E        L +  E
Sbjct: 1589 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKE 1641

Query: 7230 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 7289
            Q ++ +   ++ Q  K+  +   S +QQ+ +++    + A NK   D  +        D 
Sbjct: 1642 QYEALQEETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DW 1691

Query: 7290 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 7349
            +  +G+    L       EQL        A       + ++Q    L++     +   Q 
Sbjct: 1692 VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 1751

Query: 7350 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 7409
             +   + F  + ++ +A++ +    L  ++         +Q+++ ELK Q          
Sbjct: 1752 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY--------- 1796

Query: 7410 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWM 7469
                      L  ++ E+K++Q L                +LQ FL  H+ F    E+W+
Sbjct: 1797 -------STSLAQSEAELKQVQTLQ--------------DELQKFLQDHKEF----ESWL 1831

Query: 7470 EFLVQTEQKLAVEISGNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 7524
            E   ++E++L     G         LL++Q +   F  ++ S +  L  + I GQ++L+ 
Sbjct: 1832 E---RSEKELENMHKGGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDM 1885

Query: 7525 GQV-----DDRDEFNL---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7576
                    +  +  NL   KL   + ++  +  +  +    ++  + Q+ +++  A+ L+
Sbjct: 1886 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 1945

Query: 7577 KWL----VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL 7632
             W+      V  L    + S P  LQ+   L    Q +E++   Q     L   A   + 
Sbjct: 1946 AWMQACEANVEKLLSDTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIME 2003

Query: 7633 LSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 7691
            +  +   +   +Q     I   ++S S  L E+   L   +   +  ++ +   L+ +  
Sbjct: 2004 IEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063

Query: 7692 FK-----KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
             +     K++S       +E  A  M+ K+            + L   ++ ++ ++   D
Sbjct: 2064 VEQNLEGKQVSSLSSGVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETAD 2117

Query: 7747 ---ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 7803
                ++L  ++  + +++E+LC Q   +   + + L +  +F   + +L +++ + +S++
Sbjct: 2118 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRM 2176

Query: 7804 SQNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGK 7861
              +G+   +++    ++  +   E+   QEN   L+ +   L+         + + ++  
Sbjct: 2177 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236

Query: 7862 VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 7921
            +   +  L   +  R K        + +  K + + + WL   E  +  P    S +++E
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKE 2294

Query: 7922 IQRKLNEQQELQRD-------IEKHSTGVASVLNLC-EVLLHDCDACA------------ 7961
            +++++   + L  D       +E+ +    S+ NL  E+   D                 
Sbjct: 2295 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2354

Query: 7962 ------TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
                  T  +   IQ    +++ ++  +  +  ER+  ++      ++   + +    WL
Sbjct: 2355 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2414

Query: 8016 KSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRT 8072
            +S E    +    SS       K + +  +AF  ++ +   +++ + +    L      +
Sbjct: 2415 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNS 2474

Query: 8073 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL- 8131
              A + K++  E N RW+   +   +  R+L+        F+ A   +  WL E +L + 
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534

Query: 8132 --------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 8183
                     N+ +  +  VQ  +K+ +A +Q+    H ++ +  AQG         L  +
Sbjct: 2535 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTS 2589

Query: 8184 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDR 8243
             +++EL  + +   E+  ++     ++ +  +   ++    ++L  +  A    L     
Sbjct: 2590 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL----- 2644

Query: 8244 SADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRD 8294
            S  S +S QP +    L     +RS+        ++     D + +     Y   +L + 
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704

Query: 8295 LESAMSRALPSED-EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTE 8353
            LE+    ALP +  E+   D+   L+ A+  +     +  ++R     LDD   Q QQ +
Sbjct: 2705 LETV---ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW---LDDK--QSQQAK 2756

Query: 8354 NI-IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8412
            N  I +K           + + K L + S S + +      L     S+P      + + 
Sbjct: 2757 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGEEKRTLQN 2813

Query: 8413 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 8472
            Q   + + WE L  +   ++ R+K  +QK Q++   +  +  W+ D + ++ +L+   ++
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR---VT 2870

Query: 8473 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 8532
             D   +E  + + K +   V+ R++++  +N  +     +   +   ++D  + +N   D
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930

Query: 8533 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHH 8592
             V   L+   G L++   + + F E    +    + ++  K+++   D+ L ++   + +
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGSQACSNKN 2986

Query: 8593 KQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLKLLLKEVS 8650
             + ++ + E+L++ + +V  L++ +  L+ +A +G+D  +   +  V       + + V+
Sbjct: 2987 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3046

Query: 8651 RHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQ 8696
                 +E  L           ++ S   DL      DELD  G++    GR T + Q
Sbjct: 3047 SGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI----GRDTDSLQ 3094



 Score = 49.7 bits (117), Expect = 1e-04
 Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)

Query: 296  DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 352
            +E L     F NS+Q F             W+   E+ L  A    ++ + +  + +  K
Sbjct: 4480 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 4528

Query: 353  HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 403
             F  +    R QI  L Q  ++   LS  Q +V         +  W++V  R  +    L
Sbjct: 4529 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 4588

Query: 404  D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 457
            D      K        +  WL  AE  L  E+ +    ++    I+ +L +HK+  +   
Sbjct: 4589 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 4644

Query: 458  AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 501
              +  +    RT R++    + P+        L ++ +++  V   S        E  L 
Sbjct: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 4704

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
              +F++    L+  L   E +L      +G  + V  L+  +  F    K   +   T Q
Sbjct: 4705 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 4761

Query: 562  ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 621
            +LK++    +  + S ++   V   + E + +W  +     S +S LE+ +   + + +T
Sbjct: 4762 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 4819

Query: 622  VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 665
            V  L  WL +AE+ L       + +E      +  K+F + +    ++   +N A   G 
Sbjct: 4820 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 4876

Query: 666  FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 720
             ++  C       +K  + ++  R+ E+    KQ+ Q       E+    +   + +  +
Sbjct: 4877 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 4936

Query: 721  SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 772
                T   ++  EP+  +   VK LI +    +E++ ++ P +D   K   +      H 
Sbjct: 4937 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 4996

Query: 773  ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 828
               E  +  G++  +  +     +    E  +P + +     QQ+ +   E ++++    
Sbjct: 4997 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5056

Query: 829  DSLGKINE 836
            D L ++ E
Sbjct: 5057 DRLEELKE 5064



 Score = 34.3 bits (77), Expect = 5.6
 Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)

Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
            +L  ++  L   EE   +L+R E   D+ ++ELQ++  + +  +V+   + +    L   
Sbjct: 585  NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641

Query: 8508 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 8567
                 + K S++     ++  G+ +     L+E        L     F   +   L+ L 
Sbjct: 642  ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697

Query: 8568 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 8626
              +  +      D+N +    +++  +L     EL E Q    SLQD +  L L N    
Sbjct: 698  EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754

Query: 8627 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 8672
              +EA    V      +K L   V +H+KE        S  ++L S+
Sbjct: 755  QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  340 bits (871), Expect = 5e-92
 Identities = 667/3723 (17%), Positives = 1479/3723 (39%), Gaps = 418/3723 (11%)

Query: 2260 DLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTW 2319
            D K L K+L +  D          +L H +   E+ K  + +   Q TQ+E  + D+  W
Sbjct: 1887 DAKNLQKSLSSVSDTW------NSRLLHFQNAVEIEKTKVLN---QHTQLEGRLQDLRAW 1937

Query: 2320 FTKVEESLMNCAQNETCEA------LKKVKDIQKELQSQQSN-----------ISSTQEN 2362
                   L +   N   +       L++ +D+++ +  +++            IS   ++
Sbjct: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997

Query: 2363 LNSLCRKYHSAELESLGRAMTGLIKKHEA-VSQLCSKTQASLQESLEKHFS-------ES 2414
            L+    +     L  L R+   ++++  A V  L    Q   QE+L K          + 
Sbjct: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ 2057

Query: 2415 MQEFQEWFLGAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT----- 2467
            +++   W   A+ A      RT   D   L+    DL+++ D + +  +    V      
Sbjct: 2058 LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 2117

Query: 2468 --QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHR 2525
              +E QT    LS + +++++E++ +A E+++A  ++    ++ L++  +     E +  
Sbjct: 2118 FMEENQT---KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 2174

Query: 2526 KLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRG 2581
            K              + L E+K+ I    + V  V    G+LL     +++LS    ++G
Sbjct: 2175 KA------------AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222

Query: 2582 QLLSEEGH-GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------E 2627
             L + +G+ G  Q      + C  +   HQ LL   +  +   +S Q  L +H      E
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282

Query: 2628 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL--------------- 2671
              +   Q +    +     LA +E+ L    TL+  L + +QD                 
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342

Query: 2672 -------------LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------ 2701
                         L+K +G    ++   KG+             + +S KEG+       
Sbjct: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402

Query: 2702 VIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ 2761
            +++ +L+   E +  + S      S L  ++ Q++ +    + L+ WM++ +  +E  L 
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462

Query: 2762 P----QPG-LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQE 2815
                  PG L+E+      LQ  L+E +     L ++     E+  E   D        +
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522

Query: 2816 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSA 2875
             + + F  +     E+   +++ +       +++      +   ++ L      S  S  
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582

Query: 2876 TQKKLS---KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ 2932
             Q+ L+   K+K+ I  ++        + +   E   +TTA+        +Q   A+  Q
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQ 2635

Query: 2933 WEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD 2992
              + +   Q   E+ + ++    + F     +L+Q +E  S +L +         G   D
Sbjct: 2636 RFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPD 2686

Query: 2993 EEIVECWHKGQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCL 3050
            ++I   + + QE+   ++  +   + L+  + EL  C F+ DL  +  +V  L K++  L
Sbjct: 2687 QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTEL 2746

Query: 3051 CLQASKGCQNKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQ 3108
                 +  ++     +Q   FRK  R FQ+WL   + +     +   +  E+   ++ ++
Sbjct: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLK 2805

Query: 3109 EFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN- 3160
              L +  +    +  +  KG  L  L+ +  A   Q K       V ++      +H+  
Sbjct: 2806 SLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCK 2865

Query: 3161 ----------------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHE 3198
                                  LH+++ +L+ +  +M++    A  +  WL   E+++  
Sbjct: 2866 DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL-- 2923

Query: 3199 SSNRLYDLPAK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFR 3251
             S      P K    + + +  ++ L E+    P++ ++KE    L   +     +++++
Sbjct: 2924 KSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWK 2983

Query: 3252 HRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTS 3311
                +L+S++   + +T  +  +L+   +    F     +L+ W+ +   M+      + 
Sbjct: 2984 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043

Query: 3312 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDM 3369
            D ++L+++  +++ +L   + +  Q + +    + +L       + T  +Q++LQS+   
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQK 3103

Query: 3370 WASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAEL 3422
            W  L        SQ++ A+ K T YQ+ ++  S  + ++   L+       + E    +L
Sbjct: 3104 WVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQL 3163

Query: 3423 RDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQER 3479
             + + +    + L+ EV    +L + + V    + E Y+    +  L+ +    + +++ 
Sbjct: 3164 EETSEIRSDLEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDL 3220

Query: 3480 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3539
            A + + + +  +   Q++Q+       WL  +Q +  +   +       ++ L++ +E Q
Sbjct: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 3280

Query: 3540 VHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNN 3595
                +       ++   E ++ S  P  E R L++    L+  W+    + ++ +++  +
Sbjct: 3281 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKD 3340

Query: 3596 VVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
             + K +  +   + +  W++  + K+S   R   +    E  L + K    EV   R  +
Sbjct: 3341 CMQKAQKYQWHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLL 3399

Query: 3656 EEVGARAQEILDESHVNSR-MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
            E + + A  +++ S  +   +  +   +     A+  +       L+ +  SLEE    L
Sbjct: 3400 EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEE-------LQAKTGSLEEMTQRL 3452

Query: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREK 3770
              + + + +  K  +    +++  D +       K L+ L    + ++     +   R  
Sbjct: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512

Query: 3771 GERAVKYLEEG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
             +  V+   +G +A +L  +     ++  E+   V    + +E  L    +F  + + + 
Sbjct: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572

Query: 3830 QWIAEYQEIL-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
              +A+  + L          +  + ++ + +  L+K   L+  + + E   + + E+ E 
Sbjct: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EG 3631

Query: 3883 LLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMS 3942
             L+L+    LK +++ L      L   GK     LE  +   ED+  +L+ +       +
Sbjct: 3632 TLDLLG---LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND-ATTAA 3687

Query: 3943 GRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKL 4002
                A   +  + +E I QQLA  K   +E      +++ LQMK   + G     +Q+  
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQSAG 3741

Query: 4003 KQNVHAHLQGTKDSYSAICST-----AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 4057
            K      L+   +  +A  +T     AQR+ Q L+  L      QD L+   +WL+  + 
Sbjct: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE- 3799

Query: 4058 DLEPSPQPPLSRAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNAS 4103
            +L  + +PP +  + +K Q++  + LQ   +  +  +D+L            + D    +
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859

Query: 4104 VKTTAKDIQQTE---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ--- 4151
             +  + + + TE         + +E  LV A+   +  E I    S     L +++    
Sbjct: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919

Query: 4152 ---QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH 4208
               ++Q    RH  LE +I +N  + V   VK  QS  +  +   + V  L++K +S + 
Sbjct: 3920 QTAKIQQQIIRHKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQA 3976

Query: 4209 KEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4268
            +  + + D+    CR++  L    ++ L   R + +    V  +L +   +  ++   D 
Sbjct: 3977 R-YSEIQDR---CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028

Query: 4269 ESTAVHLEALKKLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWF 4326
            +   +H +    LAL   +  RK  ++      Q +++    ++  L++E+   ++ R+ 
Sbjct: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 4088

Query: 4327 QLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4386
             +     + ++      +     QS ++EL  W  E +  +A +  QSP  +        
Sbjct: 4089 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQR 4148

Query: 4387 HLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRK 4446
               +  E+   +++L ++ + +  ++  +    R+ + K +SDA      +SD +GQR  
Sbjct: 4149 QKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208

Query: 4447 YLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTY 4506
             ++ A+    Q+  A     + + + +RK+M    I L  D  + Q++  K+    +  +
Sbjct: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268

Query: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            ++ +  L++   E+     E++K+ +  K + L   Y+++    S R   LE+  V    
Sbjct: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328

Query: 4567 FKEDFDKACHWLKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQR 4624
            F E +++   W+++  A I   P   + +E  +L  Q  + + + E   E++  +  L +
Sbjct: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLK 4386

Query: 4625 TGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIE 4681
             G   L  LN  +   + EK       +  I    + +   + EA+       E+   IE
Sbjct: 4387 IGPQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 4445

Query: 4682 LTTQSLSELEAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
               ++L  L ++      +P ++  + E +S        L+++    EA+    ++  G 
Sbjct: 4446 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG- 4504

Query: 4741 RSTGQPWQ------PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4794
            RS G           DK+  +V  +  +K + E+R     D     +  EK    +   L
Sbjct: 4505 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALL 4561

Query: 4795 KSVKEEQSKVNEETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
             ++K+ Q  V++   P       +++++   ++          L+ + I   DL      
Sbjct: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4621

Query: 4849 LAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAE 4906
                + R  I       + L     E + + E  M  ++ +Q  +    DWL    +K  
Sbjct: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681

Query: 4907 LSGPVYLDLN-LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD- 4962
               PV  DLN ++D   E++  K++++Q++++     M  L+H+ +    KA +    D 
Sbjct: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDI 4736

Query: 4963 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----L 5018
            +   L EL  L  ++ E +  RQ  L        ++    +    WL   +ELL     +
Sbjct: 4737 IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI 4796

Query: 5019 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA-- 5076
            +G   D +  E  L  H          H    ++ +  AT++ + K  G E LE      
Sbjct: 4797 SG---DPKVIEVELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDD 4842

Query: 5077 SLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS- 5135
            +  LRS R+   +     +LQ+   +    Q   ++     ++ E  L E + +++  S 
Sbjct: 4843 ASSLRS-RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA 4901

Query: 5136 --------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMT 5186
                      A E+L  H  L S + +  E    L +K   +  + +D+ S +   +S+ 
Sbjct: 4902 SKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4961

Query: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246
             + Q+W  + +  ++++  LE+A++  T F N +++    +   +  L  +S        
Sbjct: 4962 LLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNT 5021

Query: 5247 LLTLLEYHDTF----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
            +L+ +E H  F          ++EL+Q  + L  L Q+   +L             +   
Sbjct: 5022 VLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNL 5068

Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
            + ++Q R   + ++    G+ +    K  +        +  W+++ + +L +  +EI   
Sbjct: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISND 5127

Query: 5357 LEELQILLTEATNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALD 5406
             +++++ L++    ++ +           +     KEK     T+LP + S +L     +
Sbjct: 5128 PDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGE 5181

Query: 5407 LKIR-DQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNV 5455
            ++ + D +  K  E +     +   S Q     + L   L K++ +           D V
Sbjct: 5182 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 5241

Query: 5456 VQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQA 5515
            +      KV  +EL      +  L  + ++ +E +      +  ++ +L+       + +
Sbjct: 5242 MNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 5301

Query: 5516 ENRLSKLNQAASHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE 5574
             ++ S+L QA    E + + + ++L+W+ +A + L       +    L+     H+  ++
Sbjct: 5302 VSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMK 5361

Query: 5575 --ESKEID-SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA 5631
              E K +D +   AM E +  +    C   +   +  +    EE+    K   Q L+ A 
Sbjct: 5362 KVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL 5421

Query: 5632 KDMKKFEAELKKLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKV 5686
             ++      L++L A ++ A+ TL   +   +      +K  ++  Q  + EM   +P V
Sbjct: 5422 SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDV 5481

Query: 5687 QAV 5689
              V
Sbjct: 5482 DRV 5484



 Score =  310 bits (794), Expect = 4e-83
 Identities = 678/3931 (17%), Positives = 1530/3931 (38%), Gaps = 460/3931 (11%)

Query: 3129 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH-QKESALENLKI--QMKDFEVSAEPI 3185
            +LL  L  ++ AK +Q  +++  + W +    LH Q    +E  K+  Q    E   + +
Sbjct: 1879 QLLKAL--EKDAKNLQKSLSSVSDTWNS--RLLHFQNAVEIEKTKVLNQHTQLEGRLQDL 1934

Query: 3186 QDWLSKTEKMVH-ESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL--------KEK 3236
            + W+     +++ + SN   D+ +     Q+ + + + +   + QL+ L         E 
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEH 1994

Query: 3237 AQQLWEGQ---------AASKSFRHRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHNQF 3285
            AQ L   Q            +SF+  + Q ++Q  AL    +  E+ + +  +  + N  
Sbjct: 1995 AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC 2054

Query: 3286 SLGIKELQDWMTDAIHMLDSYCHPTS--DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
               +++L  W+  A   L  +   T+  D S L      L+ L    Q +      +V  
Sbjct: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD 2114

Query: 3344 GESVLQNT----SPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3399
             E  ++      SP  +  ++++L   K+ + +L       + +LE A++          
Sbjct: 2115 IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTS-------AL 2167

Query: 3400 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEH 3459
            Q           L E++++   L D  T +G +     ++L+    +E  ++ GA + + 
Sbjct: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSS---GGQLLTNLPGME--QLSGASLEKG 2222

Query: 3460 YVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYS 3519
             +      D  + Y  + +  ++   + E +   HQE     + F +     Q  LDQ  
Sbjct: 2223 AL------DTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ-- 2274

Query: 3520 VLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDW 3579
                  H H  T  + Q LQ    E +   ++ L   E         AE + +++L+ + 
Sbjct: 2275 ------HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSE---------AELKQVQTLQDEL 2319

Query: 3580 QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLH 3639
            Q +                      Q  ++ + WL+ +E+++    +  S+  T    L 
Sbjct: 2320 QKFL---------------------QDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 2358

Query: 3640 QMKKWHEEVTAYRDEVEEVGARAQEILD----------ESHVNSRMGCQATQLTSRYQAL 3689
            +   + E+V +++ ++  V    Q++LD           S + + +  +    T RY AL
Sbjct: 2359 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 2418

Query: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
              +       L   +    + ++S  S   W  +   N + + +     D  ++ ++L T
Sbjct: 2419 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 2478

Query: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA---ERLRKEIHDHMEQLKELTSTVRK 3806
             + L +++ + H +     +K  R +  +E   A     +++     +   + L+ ++ +
Sbjct: 2479 TKQLQEELAE-HQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537

Query: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTV 3866
                L+K +  ++   +  ++L Q I E ++ L   +   +     +  L+    L+Q +
Sbjct: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597

Query: 3867 LSHEPSVKSVREKGEALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKD 3923
               + S+++ RE     +E     T   L+ K+ ++   ++ LC   +E   SL+  +  
Sbjct: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2657

Query: 3924 HEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNL 3983
             E +     ++++++   S R++A        +    QQ+      ME+     D L +L
Sbjct: 2658 AEMFEHLSGKLQQFMENKS-RMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHL 2716

Query: 3984 QMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQD 4043
                 T +  C   L     Q+    +Q  +  ++ +  T +   +      ++    + 
Sbjct: 2717 V----TELSSCGFALDLCQHQD---RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK 2769

Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QARTYLDLLCSMCDL 4099
             ++  Q WL   +  + P+ +  +S  E  KQ++H ++L +    +     ++ C    L
Sbjct: 2770 LVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2828

Query: 4100 SNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRR 4159
             N  ++ TA D Q    +I   +  +     G+   K L +E+   + D           
Sbjct: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDMSD----------- 2876

Query: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
                 +N+    +  V      L  +Q S+  I+ ++ ++        HKE N +  QWL
Sbjct: 2877 -----VNLKYEKLGGV------LHERQESLQAILNRMEEV--------HKEANSVL-QWL 2916

Query: 4220 DLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALK 4279
            +            +E++ ++ D        E              ++ AES    L  L+
Sbjct: 2917 E-----------SKEEVLKSMDAMSSPTKTET------------VKAQAESNKAFLAELE 2953

Query: 4280 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVS 4339
            + +  +Q+ K A+  L      ++ + N  + E  K+    L  RW +  ++   + +  
Sbjct: 2954 QNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQL 3007

Query: 4340 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4399
              +   L   Q+   +L  W  E++  +      S  P+M          +  E EA++ 
Sbjct: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQ 3067

Query: 4400 LLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT 4456
              + L + A  ++    D+ L+  QV ++  S  Q  V  L+D +  R   +++A+ + T
Sbjct: 3068 QHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNSRSSQIDQAIVKST 3126

Query: 4457 QFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQ 4516
            Q+   +   + +++   +++  +  I   P+ V +Q++     ++ L+   +EV      
Sbjct: 3127 QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTL 3186

Query: 4517 GRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
              EL   + EQ  K E+  +L+ +      +    + R+  L+  L S + F++ FD+  
Sbjct: 3187 CDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELR 3246

Query: 4576 HWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNE 4635
             WL            +  +   L +QL + +   +   ++      +   G+++L S+  
Sbjct: 3247 TWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306

Query: 4636 VDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQF 4694
             +    L  +L  L   +  +     D+  ++++ +   ++Y   +E     + + +A+ 
Sbjct: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM 3366

Query: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4754
              +      + +E +L      +A+L+EV      ++ LN   +   ++ +  +      
Sbjct: 3367 SELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDE 3423

Query: 4755 LVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE---------QS 4802
               +   +   TE+   +   LE+ T   +E ++  + +E++++  K +         Q+
Sbjct: 3424 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQA 3483

Query: 4803 KVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQ 4862
              N+      EKL+    +  +L+     L+  T  L + AP  D     +  HQ +  Q
Sbjct: 3484 CSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGSDASQLLHQAEVAQ 3537

Query: 4863 GELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE 4922
             E   +   +       E+++     F   +      L  +  EL G   +  +   +Q 
Sbjct: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597

Query: 4923 EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALR 4982
            +I  +++   ++      + A   + +    +   L    L+  L  L++  G + E  +
Sbjct: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3657

Query: 4983 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESAEENLKSHMEFFST 5041
             RQ  L     + + +Y+  +  ND    A+E   L    G +VE   + L     F   
Sbjct: 3658 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKE 3717

Query: 5042 E-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQRMSRDSGAQVDLL 5096
            + D     L++++ L      LI+  GK+     LE  +  +  R   +++    ++  L
Sbjct: 3718 QVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL 3774

Query: 5097 QRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFH 5156
            Q        +Q A E ++  + DTE+ ++      ++     + ++ E K L  +++   
Sbjct: 3775 QEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3833

Query: 5157 EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGF 5216
              +  L+ +  ++ ++   A +  ++  + ++  RWT L + A  ++K LED +     F
Sbjct: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893

Query: 5217 NNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ--Q 5274
            +   +  ++ +   + KL  S       A++   +  H     ++E   + +    +  Q
Sbjct: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953

Query: 5275 TLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINS 5334
            +LS L      +P E+  L ++I ++Q R   +Q++      L+ Q L +  +       
Sbjct: 3954 SLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008

Query: 5335 VKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE---KMAEEQKEKY 5385
            V  W+ E ++ L +  ++      +  Q  +   L  E  N ++N++   K  +   ++ 
Sbjct: 4009 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 4068

Query: 5386 LGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKD 5440
             G   +L  E    +  + A++ +   K    ++   +   + ++T +EL+  ++++ ++
Sbjct: 4069 TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 4128

Query: 5441 LTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELDAAVQKFLEQNGQL 5493
            L T   +     + + Q +  QK L +E       LD  N    E+  A+ + +    + 
Sbjct: 4129 LATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVSRALLELVPWRARE 4183

Query: 5494 GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAH 5551
            G  L K +    E ++        R+ +++ A    ++Y +  +  L W+   K K++A 
Sbjct: 4184 G--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241

Query: 5552 GTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--CTEK----MS 5603
            G I      +L +     Q  ++++  ID     ++M E   + + ++  C E+    + 
Sbjct: 4242 GPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ 4295

Query: 5604 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEV 5660
            ++   L ++ E +  +   R   L+ A   + +F    ++L   +E+ +A    L SP +
Sbjct: 4296 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 4355

Query: 5661 GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEAS 5720
                L++Q    + L   +   KP +  +      L+        + +     + +   +
Sbjct: 4356 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYA 4414

Query: 5721 RLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQ 5777
            +++    Q+   +  AV Q  Q   +  +++ + + +E     +   P+  + + +++  
Sbjct: 4415 QIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIREC 4474

Query: 5778 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDG 5833
            IS ++    +++  Q    +L  + + L  +++ A   L   E++   +      ED+  
Sbjct: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA 4534

Query: 5834 ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVN 5893
                       V+ +     + + + +T     +    ++ SP               ++
Sbjct: 4535 RAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP--------------GID 4580

Query: 5894 QDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWET 5946
              I   Q  +AE ++ +   +H          +   +  G   +P     + ++  +WE 
Sbjct: 4581 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640

Query: 5947 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEH 6003
            L     E+   L +A++   +YQD+LQ++   ++   +KL   P  G    + + Q+ E 
Sbjct: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEM 4700

Query: 6004 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASG 6063
            +    E+   Q E+ +L     E ++ ++   D  ++  ++  LT L      +  K + 
Sbjct: 4701 KEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAH 4757

Query: 6064 KRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQL 6123
            ++  LE  L           AL +++   +EL SWL  T+  LD       +P  +E +L
Sbjct: 4758 RQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4807

Query: 6124 MD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180
                  +N ++  +  V  +++      N LLE  A   D+A  L  +L  +      + 
Sbjct: 4808 AKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEAMNQCWESVL 4861

Query: 6181 RALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKE 6236
            +   +++  +Q T Q+ +   S+++    +   ++  L+ ++ T    +  +  L    E
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921

Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSA 6291
            L  +L  ++     +  +G  +L+    + +     +   +L Q+       ME  KS  
Sbjct: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4981

Query: 6292 EDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLYSRP-----N 6330
            E+ + +  ++++  QEF              S    +L  VL Q +E  +++       +
Sbjct: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041

Query: 6331 RLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKL 6383
            +++    +G  L K     QD   + +LL  +   +E+V   S + G +   +    ++ 
Sbjct: 5042 QIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100

Query: 6384 YDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMD------- 6434
            ++       WL+D E  L     +   P++ +  L   +   K +       D       
Sbjct: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGR 5160

Query: 6435 --KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6492
              K K L     PE+    D         LG +      V  +  + + +L++ L F   
Sbjct: 5161 ALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209

Query: 6493 LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRR 6546
                  +L D  Y +  +LA   +QPV   ++ +    D  K F        G +++ +R
Sbjct: 5210 FMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267

Query: 6547 GDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
              +  +E           +L +L   +D +  +  S++S L Q L     +   +  L +
Sbjct: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327

Query: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI------------------ 6642
             L   ++ +   +  +    E +Q L+D HKE+ + +E   +                  
Sbjct: 5328 WLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 5386

Query: 6643 -----------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW 6691
                       +    F +++++A Q + +  T L    S ++  A      L +I   W
Sbjct: 5387 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEELLAWI--QW 5440

Query: 6692 SH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPK 6745
            +    +  DQ+ + + ++ V++ I       E   R    +DR+T     K+    + P 
Sbjct: 5441 AETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPF 5500

Query: 6746 LYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNTNKMSKELHR 6789
            + +    G++ L          +S S+ ++ ++NQL   W       L    K++  L R
Sbjct: 5501 IEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDR 5560

Query: 6790 LETILKHWTRYQSE--SADLIHWLQSAKDRL 6818
            LE  LK +  +  +      + W+   K R+
Sbjct: 5561 LEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5590



 Score =  297 bits (760), Expect = 4e-79
 Identities = 724/3946 (18%), Positives = 1524/3946 (38%), Gaps = 472/3946 (11%)

Query: 4897 LDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-------VQSSLRIMNALSHKEK 4949
            L  LR ++        L+LNL ++Q+ + + ++ + E       V   L  +N +   + 
Sbjct: 1814 LSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQP 1873

Query: 4950 EK----FTKAKELISADLEHSLAELSELDGD----IQEALRTRQATLTEIYSQCQRYYQV 5001
            ++      KA E  + +L+ SL+ +S+         Q A+   +  +   ++Q +   Q 
Sbjct: 1874 QEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD 1933

Query: 5002 FQAANDWLEDAQELLQLAGNG--LDVESAEENLKSHMEFFSTEDQFHSNLE----ELHSL 5055
             +A   W+ +   +L   G+   +DV+S    L+ + +      +  + L+    ++   
Sbjct: 1934 LRA---WVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFF 1990

Query: 5056 VATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIE 5115
            ++     + P     + + +  L+   Q +   + AQVD LQ      H  Q  +E +++
Sbjct: 1991 ISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG-----HLQQMEQEALVK 2045

Query: 5116 LMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
             +   +    +      S   +AE  L+ H+   +      + + AL++  S L+   +D
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTT-----QQDLSALQKNQSDLKDLQDD 2100

Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
                        +  R T    V +D E  +E+         N+ K +   +  L++KL 
Sbjct: 2101 ------------IQNRATSFATVVKDIEGFMEE---------NQTKLSPRELTALREKLH 2139

Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
             +  +  +  E        +T V + E +++    L+Q+T             E+    +
Sbjct: 2140 QAKEQYEALQE--------ETRVAQKELEEAVTSALQQET-------------EKSKAAK 2178

Query: 5296 EITAMQ---DRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLG--NPT 5350
            E+   +   D  L+    V ++G  +   L   E + +  +  K  +  T  Y+G     
Sbjct: 2179 ELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL-SGASLEKGALDTTDGYMGVNQAP 2237

Query: 5351 IEIDAQLEEL----QILLTEATN--------------HRQNIEKMAEEQKEKYLGLYTIL 5392
             ++D Q E +    Q LL++  N              H  N+    ++  ++ LG    L
Sbjct: 2238 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGE---L 2294

Query: 5393 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5452
              + S  LA+   +LK    +QD++++  Q     +E    +++  K+L   + K  +  
Sbjct: 2295 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDH---KEFESWLERSEKELEN-MHKGGSSP 2350

Query: 5453 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5512
            + +      Q    E++      L  +  + QK L+      +   K+  ++  L +  +
Sbjct: 2351 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE--GKEPSEIGNLVKDKL 2408

Query: 5513 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5572
            + A  R + L+   + L  +   L ++L    + +  A    AW  A +   + +L  T+
Sbjct: 2409 KDATERYTALHSKCTRLGSH---LNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTV 2465

Query: 5573 LEESKEIDSELEAMTEKLQ-----YLTSVYCTEKMSQQVAELG-------RETEELRQMI 5620
              +   +  +L A T++LQ     +   V   +K+++ + E+        R  +E    I
Sbjct: 2466 ASDPGVLQEQL-ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI 2524

Query: 5621 KIRLQNL-----------QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---LK 5666
                Q+L           Q A    +  +  L+ L  ++ + +  L   +V  LS   ++
Sbjct: 2525 LSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ 2584

Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
            E L+    L  ++   K  ++A +   +      D   +  L     +L E + R +   
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG---KLAEVSQRFEQLC 2641

Query: 5727 IQQC---NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEE 5783
            +QQ    + ++  + Q E +E     LQQ +E   R +        +I     QI   +E
Sbjct: 2642 LQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI---QE 2698

Query: 5784 LAQKIKGYQEQIASLN------SKC-----------KMLTMKAKHATMLLTVTEVEGLAE 5826
            L  +++  QE + +L       S C           ++  ++     +  TV E E  A 
Sbjct: 2699 LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS 2758

Query: 5827 GTEDLDGELLPTPSAHPSVVMMTAGRC---HTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
              ++   E           +  T G      T +S    E   E   S +    +  +  
Sbjct: 2759 SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV 2818

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS----QEFYEPGLEPSATAKLGD 5939
               N   +  +++     ++A   Q     I PS  +S      ++           + D
Sbjct: 2819 EEINCKGTSLENLI--MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSD 2876

Query: 5940 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGR 5994
            +   +E L  V+ E+Q +L   L R ++      S+   +E+ E  L       SP    
Sbjct: 2877 VNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE 2936

Query: 5995 SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
            + ++Q   ++A + E+     +I +++ +LA  LV+     +      +Q  L    ER 
Sbjct: 2937 TVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERA 2996

Query: 6055 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6114
            + + +               QLEE     A   ++    +L  WL+  +  +        
Sbjct: 2997 TEVTVARQR-----------QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSI 3043

Query: 6115 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6174
            +P  + AQ    Q ML E E +     +L+   + +L  G         Q+  +L+ +  
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQ 3102

Query: 6175 SLLELQRALHDK-----QLNMQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQ 6226
              +EL   L+ +     Q  ++ T  ++   D+        Q   VQ  ++       QQ
Sbjct: 3103 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQ 3162

Query: 6227 RQSSLQQQKELEQ---ELAEQKSLLRSVASR-GEEIL-------IQHSAAETSGD---AG 6272
             + + + + +LEQ   E+ E ++L   ++   GE+ L       ++  A    G    A 
Sbjct: 3163 LEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA 3222

Query: 6273 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQE------FSTKQKLLQNVLEQEQE---- 6322
            ++ + L   L    +     D++R   +    +       S K + LQ+ L++ +E    
Sbjct: 3223 DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKS 3282

Query: 6323 --------QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
                    +V+ +    LL  VP      P ++K  + + L  L   +EE+S ++  A R
Sbjct: 3283 LNQHSGSYEVIVAEGESLLLSVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADR 3334

Query: 6375 QS-----IHLEQKLYDGVSATSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKE 6428
            QS     +   QK    V     W++D + ++  +   L P + E+ L   + +  ++++
Sbjct: 3335 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK 3394

Query: 6429 MSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN 6488
                ++   +        +  + D I D    +   +  +   +  +   ++E  Q++  
Sbjct: 3395 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 3454

Query: 6489 FQNDLKVLFTSLADNKYII-------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDA 6538
            FQ   K +   +   K+ +        Q  +N   + +  Q E +Q  E   D L+ F  
Sbjct: 3455 FQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQ 3514

Query: 6539 GIIELKRRGDK----LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERA 6594
            G++E    G      L   + + QE  +++   +   +++ ++  G+ Q      +    
Sbjct: 3515 GLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQ 3574

Query: 6595 LQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLF 6648
            L DL D L+ G   +  D   + S  E+++  L+K       +E+      HM+  E   
Sbjct: 3575 LADLDDELD-GMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL 3633

Query: 6649 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQL 6705
              +    +++E +    L  Q   + +R   R  +LE  L   E +    +   + +   
Sbjct: 3634 DLL---GLKRELE---ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3687

Query: 6706 EVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS---- 6761
            E  E+    VG   E  ++ +    ++Q  K  ++  Q KL QV   G+ L+ S      
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCD 3745

Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
               LE  + ++   W +   K+++ + +L+  L H  ++Q     L+ WL   ++ +   
Sbjct: 3746 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805

Query: 6822 TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSE 6880
               S     E ++V+  +       + +D + +    + + G ++ +  ++ D   +  +
Sbjct: 3806 KPPSA----EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861

Query: 6881 LSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 6940
            L  ++S+WT+LL+   A Q++L  + +           +  ++S+ E  +   E      
Sbjct: 3862 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP----- 3916

Query: 6941 IGYKA--IHEYLQKYKGFKIDINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQ 6995
            +G +   I + + ++K  + DI      V     + QS+  ++S   +   S+K D    
Sbjct: 3917 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID---- 3972

Query: 6996 LGAMNKSWQILQGLVTEKIQLLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQ 7054
              ++   +  +Q     K  LL+  L +   + E+ V+ L    E ++K      +   Q
Sbjct: 3973 --SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030

Query: 7055 ASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANL 7114
              +     D   L + I  ++K V++  +NG AL++    +   ++   L  +   +A++
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 4090

Query: 7115 DHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQ 7174
                 +    L+      +  +  ++++  +L E    L+     +G       Q+   Q
Sbjct: 4091 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQ 4146

Query: 7175 NLQDDLEKQERS----LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQ 7230
              Q +L+K+       L     ++  LL+       E L   + + N ++  + + I ++
Sbjct: 4147 QRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQR 4206

Query: 7231 LQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL 7290
            +    A +Q  Q+Y+    Q A         T   L A     +  D+    +Q      
Sbjct: 4207 VDEIDAAIQRSQQYE----QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262

Query: 7291 KGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG 7350
              +   KDS+  L     ++         + +Q    SL Q   A+     ++   L+  
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322

Query: 7351 VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL 7410
             +    F ++ E L  WI E   ++  Q PS + D   ++++ EE++      +   P +
Sbjct: 4323 QVLVNQFWETYEELSPWIEETRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 4381

Query: 7411 DRLNELGYRLP-LNDKE----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FL 7462
            D+L ++G +L  LN +E     ++ Q     ++ I  +  +R   L   + Q      F 
Sbjct: 4382 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 4441

Query: 7463 EKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQR 7520
            +K E  +E L     +L +   I      + E    ++    E+   Q    ++   G+ 
Sbjct: 4442 DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 4501

Query: 7521 LLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMA 7572
            L+ + Q  D+D    E   KL  +   W+ +  RA++R      +++   + W     + 
Sbjct: 4502 LIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALL 4561

Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAG 7628
              ++     V  L   G+    I  Q   A T+ +E     +E  F+R  G+        
Sbjct: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA-------- 4613

Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADS 7685
              L+ +     +  ++  + E+   W++ +   +E+ +KL   ++    ++   + + D 
Sbjct: 4614 -DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672

Query: 7686 LEK--------------LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7731
            L+               L T K +L++ + +   E++ +Q+  ++L +          +L
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GEL 4723

Query: 7732 SLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKE 7791
             L K T        D  I+ E +  L+  WE L  +++ R+ ++   L     F    +E
Sbjct: 4724 MLKKAT-----DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEE 4778

Query: 7792 LCEWLTQMESKVSQ----NGDILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKA 7846
            L  WLT  E  +      +GD  + E +E  K    +   +A +  ++ + + G  L ++
Sbjct: 4779 LMSWLTHTEELLDAQRPISGDPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837

Query: 7847 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7906
            S    AS +  +L  +N  W+ +L     R ++L+ TL   Q     +      L  +ES
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897

Query: 7907 ELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 7964
            +L+  KP        E  + +L+   EL   ++        +L+   ++L   D   + +
Sbjct: 4898 QLSASKPT---GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4954

Query: 7965 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 8024
            + +   Q+   L+++W  + +   ER+ K+EE   L  +F +    F +WL  +E++   
Sbjct: 4955 KTE---QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011

Query: 8025 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8084
             S   +I      ++++ + F  +V+    Q+  +++   +L   ++      +K ++  
Sbjct: 5012 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVS 5071

Query: 8085 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-V 8142
               RW+ + +R     R L     + ++F  A   ++ WL + +  L + +E  ++ D +
Sbjct: 5072 VQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 5131

Query: 8143 QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFG 8201
            + ++ + K FQ+ +       +  I  G  L EK+  P D+  ++  L E+R     V G
Sbjct: 5132 KLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCG 5191

Query: 8202 R-VERYHKKLIRLPLPDDEHDLSDRELE---------LEDSAALSDLHWHDRSADSLLSP 8251
            + VER HK    L       D     ++          ED     DL       D+    
Sbjct: 5192 KSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF 5251

Query: 8252 QPSSNLSLSLAQPLRSERSGRD-----------TPASVDSIPLEWDHDYDLSRDLESAMS 8300
            Q          Q L+  RSGR+               +  +   WD    LS   +S + 
Sbjct: 5252 QKELGKRTGTVQVLK--RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309

Query: 8301 RALPSEDE---------EGQDDKDFYLRGAVGLSGDHSALESQI---RQLGKALDDSRFQ 8348
            +AL   +          E   + +  LR    L  D  AL+S I   ++  K +++ R  
Sbjct: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVD 5369

Query: 8349 IQQT----ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESL 8401
            +       E I+       P+  T+ K ++ ++           R E  L   K+ ++ L
Sbjct: 5370 VNSAVAMGEVIL---AVCHPDCITTIKHWITIIR---------ARFEEVLTWAKQHQQRL 5417

Query: 8402 PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ-FNSDLNSIWAWLGDTE 8460
                     ET  + ++   ELL+      +      +Q+ Q+    +++ + A + + +
Sbjct: 5418 ---------ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQ 5468

Query: 8461 EELEQLQRLELSTDIQTIELQIKKLKEL------QKAVDHRKAIILSINLCSPEFTQADS 8514
              +E++ R +   D  T   + K ++        +     RK++        P  +Q+++
Sbjct: 5469 TFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEA 5528

Query: 8515 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSH 8560
            K       R++Q++ RW +V  L  E +  L DAL + +   E ++
Sbjct: 5529 K-----NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN 5569



 Score =  280 bits (715), Expect = 6e-74
 Identities = 668/3713 (17%), Positives = 1409/3713 (37%), Gaps = 408/3713 (10%)

Query: 736  EVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE----EGKEMFATMSK 791
            E+   ++ L +Q  ED++Q +    AQ   +         E  Q+    + ++M   +++
Sbjct: 1953 EIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNE 2012

Query: 792  LKEQLTKVKECYSPLLYESQQLLIPLEE------LEKQMTSFYDSLGKINEIITVLEREA 845
            L+     + E  +  +   Q  L  +E+      L+KQ  + +  L  +   +   ER A
Sbjct: 2013 LQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER-A 2071

Query: 846  QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF-----------DQ 894
             +    +   Q+L A Q+N      L +        F T+   ++ F           + 
Sbjct: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131

Query: 895  TRLQRQIADIHVAFQSMVKKTGDWKKHVE--TNSRLMKKFEESRAELEKVLRIAQEGLEE 952
            T L+ ++      ++++ ++T   +K +E    S L ++ E+S+A        A+E  E 
Sbjct: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA--------AKELAEN 2183

Query: 953  KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQ-------QGLQEAVRKLH 1005
            K   + LL   T   S   Q + N  L   ++L+    E+          G+ +A  KL 
Sbjct: 2184 KKKIDALLDWVTSVGSSGGQLLTN--LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241

Query: 1006 KQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1065
            KQ                              C     R  +L+ Q+ +  +  +    F
Sbjct: 2242 KQ------------------------------CEMMKARHQELLSQQQNFILATQSAQAF 2271

Query: 1066 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1125
             D+  H+L  +  Q++++   +L  ++    +       LK+++   D   +K ++D   
Sbjct: 2272 LDQHGHNLTPEEQQMLQQKLGEL--KEQYSTSLAQSEAELKQVQTLQDEL-QKFLQD--- 2325

Query: 1126 WKDYTSRFSEFSSWISTNETQLKGI-KGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1184
                     EF SW+  +E +L+ + KG +        +KR      + ++ +G+     
Sbjct: 2326 -------HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378

Query: 1185 KSRLKVLTEVSSENEAQKQGDELA-----KLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1239
             S  KVL   +S  E  K+  E+      KL  + +    L S+  ++ S+    +    
Sbjct: 2379 ISGQKVLDMENSFKEG-KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 2437

Query: 1240 IVKNSLEELISGSKEVQEQAEKIL-DT---------ENLFEAQQL---LLHHQQKTKRIS 1286
              +NS + L +  +  +   EK+L DT         E L   +QL   L  HQ   +++ 
Sbjct: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497

Query: 1287 AKKRDVQQQIAQAQQGEGGLPDRGH--EELRKLESTLDGLERSRERQERRIQVTLRKWER 1344
               RD+ +      +GE   PD  H  E    + S    L  S   +   +Q  + + + 
Sbjct: 2498 KVARDIME-----IEGEPA-PDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2551

Query: 1345 FETNKETVVRYLFQTGSSHE--RFLSFSS---LESLSSELEQTKEFSKRTESIAVQAENL 1399
             + + E++++ + +   + E  +  S SS    E+L++ ++  ++ +++  S+    E +
Sbjct: 2552 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2611

Query: 1400 VK-----EASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSN 1454
             +     +++   +       + Q+ + +  Q ++ E +L++ +   EM           
Sbjct: 2612 TRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEM----------- 2660

Query: 1455 FETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV 1514
            FE LS  + +  +  + +  S +  D  I+     IQE+  ++      +E   +    V
Sbjct: 2661 FEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED---QQENLDTLEHLV 2717

Query: 1515 TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDK 1574
            T   S      L Q +   + LR+    L+ T+          +E L + ++ V  F+  
Sbjct: 2718 TELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKW 2777

Query: 1575 L------AVPIKICSSATETYKVLQEHMDLCQ-----------------ALESLSSAITA 1611
            L        P +   SA E  K ++    L                   +LE+L   ITA
Sbjct: 2778 LKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2837

Query: 1612 -------------FSASARKVVNRDSCVQ------EAAALQQQYEDILRRAKERQTALEN 1652
                           +S   V    +C        + + +  +YE +     ERQ +L+ 
Sbjct: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897

Query: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
            +L   + + KE +S L WLE  E    S  MD  +   K E      ++ +  +      
Sbjct: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKS--MDAMSSPTKTETVKAQAESNKAFLAELEQN 2955

Query: 1713 YSKLLQLKES----LFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1768
              K+ ++KE+    L +  +  + +  K   E+L+ RW    ++   R   L+   +   
Sbjct: 2956 SPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLA 3015

Query: 1769 QFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLA 1828
             F         W+      +     +SI  + +   + +      E +    Q  Q + A
Sbjct: 3016 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEA 3075

Query: 1829 KLGSLGRAEDLHLLQGKAEDCFQ-LFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
              G L    D+ L   + +   Q + ++  ++ ++     S + + +        +L+ L
Sbjct: 3076 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 3135

Query: 1888 RQTVEATNSMNKNESDLIEKD--LNDALQNAKALESAAVSLDGILSKAQ-----YHLKIG 1940
             + V A       +S +  +   +   L+    + S    LD  + +AQ       + IG
Sbjct: 3136 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 3195

Query: 1941 SSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEER 2000
                +   +   + +   ++ +++L   + +   A     + FQ   +EL   ++D + +
Sbjct: 3196 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255

Query: 2001 TDKERLKEPTRQALQQRLRVFNQLEDELNSH--EHELCWLKDKAKQIAQKDVAFAPEVDR 2058
              K        + LQ +L+   + +  LN H   +E+   + ++  ++         +  
Sbjct: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 3315

Query: 2059 EINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ-NLKSAVSKVLENASSVIVTRTTIKD 2117
            ++  L+  W++  +   + Q +    +   ++YQ +++  V  + +  + +   R T+ D
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-D 3374

Query: 2118 QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS---SDFSLVKTDMEST 2174
               L+ +  + +   N++  ++  L+   S    L++  +        + + +  +M++ 
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434

Query: 2175 VDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE 2234
             ++    +  LEE   RLR      +   +   ++EG         A++   + + L ++
Sbjct: 3435 TEELQAKTGSLEEMTQRLR---EFQESFKNIEKKVEG---------AKHQLEIFDALGSQ 3482

Query: 2235 ELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEITE 2293
                +   +++ +   L+ L  +V+ L+  T+ L E  PD     +D  Q L  A+   +
Sbjct: 3483 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQ 3538

Query: 2294 VAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQ 2353
                  +   +    +E  +  I  +  +V E     A  +  + L  +  I ++  S Q
Sbjct: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD--DELDGMGAIGRDTDSLQ 3596

Query: 2354 SNISSTQENLNSL-------------CRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2400
            S I   +  LN +             CR  H  E E     + GL ++ EA+++ C K  
Sbjct: 3597 SQIEDVRLFLNKIHVLKLDIEASEAECR--HMLEEEGT-LDLLGLKRELEALNKQCGKLT 3653

Query: 2401 ---ASLQESLEKHFSESMQEFQEWFLG---AKAAAKESSDRT----GDSKVLEAKLHDLQ 2450
                + QE LE      +++F     G   A  AA+E+         + +++  +L D +
Sbjct: 3654 ERGKARQEQLELTLGR-VEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3712

Query: 2451 NI-LDSVSDGQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQ 2508
                + V   Q KL  V   GQ L     K   V  ++  + + N  +    K+  +   
Sbjct: 3713 MFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA 3772

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
             LQ+     G F+D    L  W+ + EE         + Q  P  + +V K ++   +LL
Sbjct: 3773 QLQEALLHCGKFQDALEPLLSWLADTEELI-------ANQKPPSAEYKVVKAQIQEQKLL 3825

Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCS-QLLTSHQNLLRMTKEKLRSCQVALQEHE 2627
              +  LD       +L  EG    Q   L   + +T     L     +L S   A Q+  
Sbjct: 3826 --QRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ- 3882

Query: 2628 ALEEAL---QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE------ 2678
             LE+ L   +      + I D L+  E  L + + +  + ++IQ  ++     E      
Sbjct: 3883 -LEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941

Query: 2679 -VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWND 2737
               ++ A+  G+     ++   Q V+  ++++L+  +++I        + L+  +S    
Sbjct: 3942 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL 4001

Query: 2738 YVERKNQLEQWMESVDQKIEHPLQ---PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
            + E + ++  W+  V+ K+         Q  L  +    DHL ++  E  +  + + + I
Sbjct: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHA--DHL-ALNEEIVNRKKNVDQAI 4058

Query: 2795 AKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
               + L ++T  E      QE+L   KT++ DI   + + +R +E+  +    +     E
Sbjct: 4059 KNGQALLKQTTGEEVL-LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 4117

Query: 2852 FTDWLHSAKEELHRWSDMSGDSSAT-------QKKLSKIKELIDSREIGASRLSRVESLA 2904
             T WL   +EEL      SG  S T       Q++  ++K+ +    +    ++ V    
Sbjct: 4118 LTGWLREVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 4173

Query: 2905 PEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ 2964
             E+       G + + ++       +K   D++ Q    ++  + +    EQ    ++A 
Sbjct: 4174 LELVPWRAREGLDKLVSD---ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 4230

Query: 2965 LEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE--DLKSQ 3022
            + +   +  AL     +Q         D+   +   +    +D ++  +   E    +S+
Sbjct: 4231 VAETKRKLMALGPIRLEQ---------DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 4281

Query: 3023 LNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKE--QILQQRFRKAFRDFQQWL 3080
            +   C      +    K   LI++Y  + L  S+     E  Q+L  +F + + +   W+
Sbjct: 4282 IFGTCG-EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWI 4340

Query: 3081 VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN-GQHK--LNMMLSKGELLSTLLTK 3137
               +   A+   +P    +     Q+ +E     E+  +HK  ++ +L  G  L   L  
Sbjct: 4341 EETRALIAQ---LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNP 4396

Query: 3138 EKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVH 3197
            E+ + ++ K   A+  +      + Q+  AL+    Q        + I+  L   E +  
Sbjct: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL-- 4454

Query: 3198 ESSNRLYDLPAKRREQQKL-------QSVLEEIHCYEPQLNRLKEKAQQL------WEGQ 3244
              S+RL   P    E  K+       +S   E+   +P    LK + ++L       +  
Sbjct: 4455 --SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512

Query: 3245 AASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLD 3304
             A+K  + ++ Q+   +  +    +E+  +   ++    +F   +  L   + D   ++ 
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572

Query: 3305 SYCHPTSDKSVLDSRTLKLEALLSVKQEKE---IQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
                P  D S++     ++EA  ++K+E +    +++ I   G  ++        P +++
Sbjct: 4573 DLESPGIDPSIIKQ---QVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3421
             +  + + W +L         +LE A+     YQD ++    W+D+    L        +
Sbjct: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689

Query: 3422 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM-------TEHYVTQLELQDLQERYR 3474
            L      L + K    EV      +E +  +G  M       T+  + +  L +L+  + 
Sbjct: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749

Query: 3475 AIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRD 3534
             + E+      K E  +    ++Q  L+    WL   +E LD    + GD    E  L  
Sbjct: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4809

Query: 3535 LQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA------LESLRQDWQAYQHRLSE 3588
               L+      QA + +V     +++ S    A D A      LE++ Q W++   +  E
Sbjct: 4810 HHVLKNDVLAHQATVETVNKAGNELLES---SAGDDASSLRSRLEAMNQCWESVLQKTEE 4866

Query: 3589 TRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV 3648
               Q  + + + +    + +     L   E ++S          T   QL    + + ++
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926

Query: 3649 TAYRDEVEEVGARAQEIL---DESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ 3705
             A  +   ++  + + +L   D+S   S+       L  ++  +  ++ E+   LEE + 
Sbjct: 4927 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4986

Query: 3706 SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3765
               E ++SL  + +W     ++    +     ++TV+   +++  +V   ++      + 
Sbjct: 4987 LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVL--SQIEEHKVFANEVNAHRDQII 5044

Query: 3766 SAREKGERAVKYLEEGEAERLRKEIHDHME-QLKELTSTVRKEHMTLEKGLHLAKEFSDK 3824
               + G + +K+L + +   L K +   ++ + +++     +   +L+     AK+F + 
Sbjct: 5045 ELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103

Query: 3825 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3884
             K L  W+ + +  L    E   +  + K QLSK+K  Q+T+   +P   +    G AL 
Sbjct: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALK 5163

Query: 3885 ELVQDVTLKDKIDQLQSDYQD----LCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ 3940
            E         K+D    + +D    +C    E    LE  +     +   LQ +  WL +
Sbjct: 5164 EKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYK 5223

Query: 3941 MSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 4000
            +  +L A D      L+ +   +  HK   +E+      +  L+  G  LI    D    
Sbjct: 5224 VEPQL-AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282

Query: 4001 KLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLS------- 4053
                 V   LQ     +  +C  +      LE  L++    +DT+     WLS       
Sbjct: 5283 -----VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337

Query: 4054 ---AVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCD------------ 4098
               A+  D E       +  E +K+V+  R     A    +++ ++C             
Sbjct: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397

Query: 4099 ---LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQN 4155
                    V T AK  QQ  +T   +LV    L +          EL  ++Q A+  L  
Sbjct: 5398 IIRARFEEVLTWAKQHQQRLETALSELVANAELLE----------ELLAWIQWAETTLIQ 5447

Query: 4156 MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH 4208
              +      ++  + ++++ + F++++  KQ  V+ + +      +K   P H
Sbjct: 5448 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIEPTH 5497



 Score =  264 bits (675), Expect = 3e-69
 Identities = 712/3997 (17%), Positives = 1515/3997 (37%), Gaps = 541/3997 (13%)

Query: 1856 ASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQN 1915
            A+Q V  RQL L H  E L S+ SL      LR     T  +   E +L E  L D L  
Sbjct: 1793 ATQNVFTRQLCLEH-DEKLVSYLSL------LRNIEMRTKQIQPLELNLAE--LQDLLCQ 1843

Query: 1916 AKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADA 1975
            AK LE     L  ++S+                         E+E +  ++ ++  E  A
Sbjct: 1844 AKVLERELKDLTTLVSQ-------------------------ELECVNQIIISQPQEVPA 1878

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
               L KA +   + L KS+  + + T   RL         ++ +V NQ   +L     +L
Sbjct: 1879 Q--LLKALEKDAKNLQKSLSSVSD-TWNSRLLHFQNAVEIEKTKVLNQ-HTQLEGRLQDL 1934

Query: 2036 -CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI--------- 2085
              W+ +K   +  K      +VD  +N     ++D K+ + E + Q   L          
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVD-SLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISE 1993

Query: 2086 -----------DLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2134
                        ++R    L+ +   +LE  ++ +        Q + +      +  +N 
Sbjct: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT 2053

Query: 2135 MNYKQKDLDNFTSKGKHLL------------SELKKIHSSDFSLVKTDMESTVDKWLDVS 2182
             + + +DL ++  + +  L            S L+K + SD   ++ D+++    +  V 
Sbjct: 2054 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQSDLKDLQDDIQNRATSFATVV 2112

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFES 2242
            + +E  M+  +  LS   ++ + R+++         Q  E    L    R  +  KE E 
Sbjct: 2113 KDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQEETRVAQ--KELEE 2161

Query: 2243 EVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEHAKEITEVAKGTLKD 2301
             V +   +  E      +L E  K ++   D +  + +   Q L +   + +++  +L+ 
Sbjct: 2162 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 2221

Query: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSN-ISSTQ 2360
                +T     +N       +  E L     ++ CE +K      +EL SQQ N I +TQ
Sbjct: 2222 GALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQELLSQQQNFILATQ 2266

Query: 2361 ENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA----SLQESLEKHFSES 2414
                 L +  H+   E + + +   G +K+  + S   S+ +     +LQ+ L+K F + 
Sbjct: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQD 2325

Query: 2415 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
             +EF+ W   ++   +         + L + L    +  + V   +  L  VT  GQ + 
Sbjct: 2326 HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL 2385

Query: 2475 --------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
                         +I + +++++  A E + A   +C +    L     +   F++    
Sbjct: 2386 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 2445

Query: 2527 LNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL 2583
            L  W+   E   E+  ++ +      + E+     +++  L E     E L K+++   +
Sbjct: 2446 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DI 2503

Query: 2584 LSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640
            +  EG  A     +      +L+  Q+L     E+    Q A+ + ++++E+L+S+   +
Sbjct: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563

Query: 2641 KAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2696
              ++  L   + S+L S   ++ L   +   QDI   K   E    M      + + +++
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT----RFMETAD 2619

Query: 2697 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
                 V+Q +L  + + +  +       +S+L+ ++ Q   +     +L+Q+ME+  + +
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679

Query: 2757 EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEE 2816
                QP   +   F  +  L   + + +++   L  L+ +        +    +D  Q  
Sbjct: 2680 ASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN- 2738

Query: 2817 LKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSAT 2876
            L+  F ++    KE+ +      +    +   V  F  WL   +  +   ++ S  +   
Sbjct: 2739 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETSMSAKEL 2797

Query: 2877 QKKLSKIKELIDS--------REIGASRLSR----VESLAPEVKQNT------------- 2911
            +K++  +K L+D          EI     S     +E  AP+ +  T             
Sbjct: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857

Query: 2912 ----------TASGCEL-------------MHTEMQALRA----------------DWKQ 2932
                      T   C++             +H   ++L+A                 W +
Sbjct: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917

Query: 2933 WEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQALEQFSALLKTWAQQL 2983
             ++ V ++   + +      V   A S + F  ++ Q    +++  E  + LL T+    
Sbjct: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977

Query: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL-------NELCRFSRDLSTY 3036
                 K   EE+   W +  E+  A Q+   + E+  S L       ++L  +  +    
Sbjct: 2978 EAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAAESQLRPWLMEKELM 3034

Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
             G +  L  + N L  Q     + + Q + + F    +  +Q    A+       D+  +
Sbjct: 3035 MGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089

Query: 3097 ISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTLLTKEKAKG----IQ 3144
             S+V   LQ I     E   +  +   +++  + K     ELL  L  K +A G    +Q
Sbjct: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149

Query: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VSAEPIQDWLSKTEKM 3195
            + ++   E  K       +  S LE L  ++K+ +         +  + ++D L K  + 
Sbjct: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209

Query: 3196 VHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY--------------EPQLNRL 3233
            V      L DL A R  +        Q+ Q + +E+  +                +L RL
Sbjct: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269

Query: 3234 KEKAQQLWEGQAA---------------------------SKSFRHRVSQLSSQYLALSN 3266
            + + Q+  E Q +                            ++ ++++ +L + +  LS 
Sbjct: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329

Query: 3267 LTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEAL 3326
             T ++ SRL   + +  ++   +++L  W+ D    + S    T D   L+S  L+ +A+
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLLRSKAM 3388

Query: 3327 LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            L+ + EK   +  I+     +L N+S       +     ++D  A +         +L+ 
Sbjct: 3389 LN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAGINQNMDAVTEELQA 3440

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLL 3446
                       +R+F     ++E  + E  +   E+ D       +    E++ +   +L
Sbjct: 3441 KTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499

Query: 3447 ETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQERAKEAVTKSE-KLV 3491
            + +E +         G+ E      +   L       Q+ +  +++R        E KL 
Sbjct: 3500 QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE 3559

Query: 3492 RLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ-------ELQVHCAE 3544
             + Q + R  + F   L    ++LD    +  D  + ++ + D++        L++    
Sbjct: 3560 GIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3618

Query: 3545 GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLME 3604
             +A    +L     +   G+     R LE+L +       R    + Q    + ++    
Sbjct: 3619 SEAECRHMLEEEGTLDLLGLK----RELEALNKQCGKLTERGKARQEQLELTLGRVEDFY 3674

Query: 3605 QKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWH-EEVTAYRDEVEEVGARAQ 3663
            +K + +++    AEE  + +    +       QL   K +  E+V   + ++++V    Q
Sbjct: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734

Query: 3664 EILDESHVN---SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720
             ++  +  +     +     ++ +R+  L  +V ++I  L+E +    + + +L     W
Sbjct: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSW 3794

Query: 3721 YGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKY 3777
               T +   N K  + +   V   +  +KL  L+ LL D +    +L++   +G R  + 
Sbjct: 3795 LADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDMLQA---EGGRIAQS 3849

Query: 3778 LEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3837
             E  + E++  ++     +  EL S        LE  L LAK+F +  + ++ +++  ++
Sbjct: 3850 AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEK 3909

Query: 3838 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV---TLKD 3894
             L   E    +  + + Q+ ++K+L++ + +H   V    + G++L  L        L +
Sbjct: 3910 KLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSE 3969

Query: 3895 KIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETS 3954
            KID LQ+ Y ++          L+  + +   +  +  EV  WL ++  +L +   ++  
Sbjct: 3970 KIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-FVKDF 4028

Query: 3955 SLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTK 4014
              + + +Q A H A+ EEI   +  ++     G  L+ Q        +++     L G K
Sbjct: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK----LDGIK 4084

Query: 4015 DSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIK 4074
              Y+ I  T+ +  ++LE   Q     Q T ++   WL  V+ +L  S      ++   +
Sbjct: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG----GQSPTGE 4140

Query: 4075 QVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEE 4134
            Q+  F+  Q++ +  +     + D  N   +   + +    +    KLV   N     E+
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN-----EQ 4195

Query: 4135 IKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK-----KLQSKQASV 4189
             K +   +   + + D  +Q  ++     +  +A   V++ K  +      +L+  Q + 
Sbjct: 4196 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLMALGPIRLEQDQTTA 4253

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-EDLQRTRDYHDCMNV 4248
               ++K   +          E+     +    C +     LQ + E L +  +    +N 
Sbjct: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313

Query: 4249 --------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4300
                     +V + +F   ++ L+    E+ A+ +  L   A+  ++ +   E+++  ++
Sbjct: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLRE 4372

Query: 4301 KMIEH----------------LNLDDKELVKEQTSHLEQRWFQLEDLIKRK---IQVSVT 4341
             + EH                LN ++ E+V+E+    E  + Q+++ ++++   +  +V+
Sbjct: 4373 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVS 4432

Query: 4342 NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNLLMDHLAICSELEAK 4397
               ++     + + ++E  E    N++  L+  P      D  +  + D+ +   ELE  
Sbjct: 4433 QSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL 4488

Query: 4398 QMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRR-----KYLNKA- 4451
            Q   ++L +  + ++      ++ +  K + D    +    + +  R      K+L+   
Sbjct: 4489 QPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLE 4548

Query: 4452 LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4511
            L+EK  + MA    T  I+  +  +   E   + P  + +QV+  ++ +        E+ 
Sbjct: 4549 LAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELE 4606

Query: 4512 GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4571
             +   G +L+    E EK EV   + E+ + ++++ +    RL++LE  + +   +++  
Sbjct: 4607 FIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTL 4666

Query: 4572 DKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSPEYENLLLTLQRTGQ 4627
                 WL    I   T P +   +N   +   ++ +++  + +Q  E E L       G+
Sbjct: 4667 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL----NHQGE 4722

Query: 4628 TILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE----- 4681
             +L  + +E D   + E L  L   +  +      + +K++ A+LA  ++   +E     
Sbjct: 4723 LMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSW 4782

Query: 4682 LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SLQDGCRAILDEVAGLG 4727
            LT T+ L +           +E +  +   +  D+   +A   ++      +L+  AG  
Sbjct: 4783 LTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-- 4840

Query: 4728 EAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMC 4787
               D+ +  +    +  Q W+        ++  + + + +Q  S L+     + E E   
Sbjct: 4841 ---DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQSTLQQAQGFHSEIEDFL 4889

Query: 4788 QQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP 4844
             +L R   QL + K             +  +++Y  L    +    +L +  + L     
Sbjct: 4890 LELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML---LS 4946

Query: 4845 HLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVK 4904
              D  +  K    +   + +  +++S + E  ++ E  +  + +FQ  +   ++WL   +
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006

Query: 4905 AELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELISADL 4963
              L+      L L  +  +I + ++   EV +    +  L     + KF   K+ +    
Sbjct: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066

Query: 4964 EHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGL 5023
               ++  S  +  +Q ++  R  +L +   + +++++ ++   DWLEDA           
Sbjct: 5067 NLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWLEDA----------- 5114

Query: 5024 DVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQ 5083
                 E +L S +E  +  D+    L +      TL       GK    Q V    +R+ 
Sbjct: 5115 -----ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK----QPVYDTTIRTG 5159

Query: 5084 RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLS 5143
            R  ++           T    D QK    +   + +   K            H+ EE L 
Sbjct: 5160 RALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205

Query: 5144 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQ-----RWTRLRAV 5198
                 +  + +  + +  +E + ++ +    D            V+Q     R   ++ +
Sbjct: 5206 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 5265

Query: 5199 AQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV 5258
             +   +++E++ D+ T    ++++ +   D +  KL  S   +  +A L     + DT  
Sbjct: 5266 KRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQA-LKQAEVFRDTVH 5323

Query: 5259 LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEK-VKTNGKL 5317
            + LE    A     +QTL     GA P   E   L   I   ++    ++EK V  N  +
Sbjct: 5324 MLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEFMKKVEEKRVDVNSAV 5374

Query: 5318 VKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM 5377
               E+         I ++K W+          TI I A+ EE+   LT A  H+Q +E  
Sbjct: 5375 AMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV---LTWAKQHQQRLETA 5420

Query: 5378 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5437
              E       L  +L     +Q AE  L  + ++ I   I  V+   A  Q    ++ + 
Sbjct: 5421 LSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 5477

Query: 5438 AKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPL 5497
              D+  +    K K      A   +K       G    L +        L Q+    +  
Sbjct: 5478 QPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPPMPILSQS----EAK 5529

Query: 5498 AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5534
              +I +L+   QQ    A  R  KLN A   LEE  E
Sbjct: 5530 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566



 Score =  264 bits (674), Expect = 3e-69
 Identities = 655/3421 (19%), Positives = 1371/3421 (40%), Gaps = 381/3421 (11%)

Query: 5419 EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKL-M 5477
            E ++   +   L R I+   K +  +   L    D + QAK    VL  EL    + +  
Sbjct: 1805 EHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAK----VLERELKDLTTLVSQ 1860

Query: 5478 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 5537
            EL+   Q  + Q  ++   L K + K  +  Q+++    +  +      S L  +   +E
Sbjct: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914

Query: 5538 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 5597
                 IEK KVL   T        LR  ++ ++ L+  SK  +SE++  +  L       
Sbjct: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968

Query: 5598 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 5655
              + M+++ A+L     +++  I    Q+L     + M +   EL++  Q  LEQ  A +
Sbjct: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028

Query: 5656 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 5715
             + + G L   EQ +  + L  +  +   +++   LC S +   E  +A     H     
Sbjct: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080

Query: 5716 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 5775
            Q++ S LQ       ++      +   +   +K ++  +E    ++  + + T+  ++L 
Sbjct: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139

Query: 5776 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 5834
                ++E L ++ +  Q+++  ++ S  +  T K+K A         + LAE  + +D  
Sbjct: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190

Query: 5835 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 5893
            L    S   S      G+  T L  + + SG       + +       +      D    
Sbjct: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245

Query: 5894 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 5946
               A +Q L +++     A     T ++Q F +       P  +     KLG+L+  + T
Sbjct: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300

Query: 5947 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 6003
                   + + +    +  QK+    +   + +E  E +L    + G SPE   S +   
Sbjct: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360

Query: 6004 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 6059
             +  ++++  + ++  +  S  + L  E+   +  E   +    +  L    ER + +  
Sbjct: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420

Query: 6060 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 6117
            K +     L   LN  L +  Q      ++  AD L +W+ + +A ++  LS     +P 
Sbjct: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470

Query: 6118 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 6171
             ++ QL   + +  E+ +  V + +L  V  + + +EG+      H ++  + +    + 
Sbjct: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530

Query: 6172 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 6228
            L  SL E + +L  K +    + QE  ES       QS G  E   + +   +      Q
Sbjct: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584

Query: 6229 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
             +L    +L+Q++A QKS L   R + +R  E     +AA   G   E      Q    +
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK S+  ++  + E + +  S K   LQ  +E +                 L  G+ P 
Sbjct: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            QD +     +  LN   E+        +++++   + L   +S+    LD  + +  V  
Sbjct: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738

Query: 6406 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6465
             L  + TE     +E   KD     E++D+ + L           +  +++T G      
Sbjct: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783

Query: 6466 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 6525
            S+  +  +    +++++++ + +  +D     T + +     +       E  + E    
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838

Query: 6526 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 6584
              Q + G      G       G     +   +Q ++S +   Y++L  ++  R+  L   
Sbjct: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898

Query: 6585 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 6640
            L    +  +    +   LE+ +E +     +   +K E ++   + +K +   LE +   
Sbjct: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958

Query: 6641 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 6695
               + E L   ++++   +E +   ++  + ++  +RA +  V  +  LE + SHL    
Sbjct: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018

Query: 6696 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6755
              + +L   L   E  +  +G +  + + L  +    Q +       + +  Q+ +  + 
Sbjct: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078

Query: 6756 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6810
            +L     +S+S S ++ +L  + + W+  T+K++    +++  +   T+YQ    DL   
Sbjct: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138

Query: 6811 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 6866
            +++   RL   +    Q   V Q+LE   +  +   +   EV +AQ+      +  G Q 
Sbjct: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198

Query: 6867 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 6923
            L+    K+++T  L   L  ++    D +  + A      Q Q           E+ +W+
Sbjct: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249

Query: 6924 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 6980
               ++   K   N   S   + +   LQ+ + F+  +N    + + +    +S+L +S  
Sbjct: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305

Query: 6981 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 7040
              E KR+       QL  +   W+ L     ++   L+  ++   +Y+ +V+ L  W E 
Sbjct: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361

Query: 7041 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 7099
             + ++ +     D   ++++L   + + + ++ +   +E +      LI + + D   I 
Sbjct: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421

Query: 7100 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 7144
                     + +   EL     +L+ M  +L+   +S  +     + + H++  FD + S
Sbjct: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481

Query: 7145 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7204
                 + +L + R     L+A++ QVD L+N    L +        GS  +QLL +    
Sbjct: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536

Query: 7205 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 7250
              E L     EV  R N+   ++E   E + Q    + +++ +  D            + 
Sbjct: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591

Query: 7251 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
              S   Q ED    L K    K DI   E      +C  +L+  GT+ D L    EL   
Sbjct: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645

Query: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
             KQ    +     + +QL L+  L  +E    K +     G+ D  T A+  EAL+ W+V
Sbjct: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697

Query: 7370 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7427
              E EI+  Q     +D    Q E+++ L+ ++ + + +   L  +   G    +   E 
Sbjct: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750

Query: 7428 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 7485
              M+ +N  W+ ++ +  +R ++LQ  LL    F +  E  + +L  TE+ +A +   S 
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810

Query: 7486 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7545
             Y+ +  Q +  +L Q  +  R+  +  +  +G R+ +  ++ DR++   +L  L ++W 
Sbjct: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870

Query: 7546 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7605
             ++ +A  R+  ++  +   +++ E AE +  +L   S        S P+  Q A+    
Sbjct: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927

Query: 7606 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 7655
             ++ K  E+            V+ G Q L S  S AE         +LQA  +EIQ++  
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986

Query: 7656 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 7710
              +  L++         +D  +    +A+  +KL     + FK+ +       H  L+ E
Sbjct: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046

Query: 7711 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7769
             + R K ++ A+ +        +LLK T     + +++ ++ E+++ ++ ++ ++    S
Sbjct: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 7828
               + + +       F    +EL  WL ++E +++ +G      E I + ++  +E    
Sbjct: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155

Query: 7829 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 7884
              E+++ L  + E +++A  E    +A E ++  +   N++++ + D I  RV ++   +
Sbjct: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214

Query: 7885 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7942
               QQ ++   +   W+A  + +L    PI  +    ++   +L  Q+    DI +H   
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271

Query: 7943 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 8002
            +  + +    +   C     + +   +Q+ T +L +++  I  ++ ER  ++E    L  
Sbjct: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327

Query: 8003 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
            +F + Y     W++ +    A   S  + +   +++ ++    +  + E    ++ + K 
Sbjct: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387

Query: 8063 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 8118
              +L   N  +      +MV E  Q+ +N+  ++   +R+    L   + Q  +     D
Sbjct: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442

Query: 8119 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 8168
             I   L  ++          L    ++   EC     I   K+   E+       E +  
Sbjct: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497

Query: 8169 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 8224
            +GE+LI +S+  D    A  I+++LD++  + +++  R E                   +
Sbjct: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538

Query: 8225 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 8284
            RE++  D   L++  W+D +A  L + + + ++   L  P       +    + ++I  E
Sbjct: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597

Query: 8285 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDD 8344
             D    L  +LE             G+ +K    +    ++     L    ++  + L+D
Sbjct: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654

Query: 8345 SRFQIQQTENIIRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
            +     Q ++ +++          K  T P + T        L E       V+  + ++
Sbjct: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQI 4712

Query: 8395 KEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQF 8445
            + E+ +  G + L     +T   I R         WE L  +   ++ +++  L    QF
Sbjct: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
               L  + +WL  TEE L+  +   +S D + IE+++ K   L+  V   +A + ++N  
Sbjct: 4773 QHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830

Query: 8506 SPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 8564
              E  ++ +  ++  L+ RL  MN  W+ V    EE    LQ  L Q QGFH      LL
Sbjct: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890

Query: 8565 MLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMS 8616
             L  ++ + +   P         E L  H +   Q+K      ++LL+    +   +D S
Sbjct: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950

Query: 8617 CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSAD 8676
                   +    LE  +K HV+ ++++   +  S+  + L    +  +S Q+  +W +  
Sbjct: 4951 GSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLA 5005

Query: 8677 E 8677
            E
Sbjct: 5006 E 5006



 Score =  259 bits (663), Expect = 6e-68
 Identities = 719/3921 (18%), Positives = 1514/3921 (38%), Gaps = 571/3921 (14%)

Query: 4366 NIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ---- 4421
            NI    KQ  P ++    L D L     LE +   L +L+      +  + +++ Q    
Sbjct: 1819 NIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPA 1878

Query: 4422 ----VIQKALSDAQSHVNCLSDLVGQRRKYLNKALS-EKTQFLMAVFQATSQIQQHERKI 4476
                 ++K   + Q  ++ +SD    R  +   A+  EKT+ L    Q   ++Q     +
Sbjct: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWV 1938

Query: 4477 MFRE-----------------HICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4519
              +                  ++CL   +  KQ    + AQ     +  +         E
Sbjct: 1939 GNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFI-----SE 1993

Query: 4520 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4579
              ++++ Q+  ++L  L ELQ  +  +L++ + ++  L+ +L                ++
Sbjct: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ--------------ME 2039

Query: 4580 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQ-RTGQTILPSLNEVDH 4638
            Q  +V      L  + +  H QL   +++     + E  L   Q RT Q  L +L + + 
Sbjct: 2040 QEALVK----TLQKQQNTCHQQL---EDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQ 2091

Query: 4639 SYLSEKLNALPRQFNVIVALAKD--KFYKVQEAILARKEYASLIELTTQSLSELEA--QF 4694
            S L +  + +  +      + KD   F +  +  L+ +E  +L E   Q+  + EA  + 
Sbjct: 2092 SDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEE 2151

Query: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4754
             R+++   + AV  AL  +        E+A   + +D L        S+G      ++L 
Sbjct: 2152 TRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG-----GQLLT 2206

Query: 4755 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4814
             +    +L   + ++ +L  DTT  Y    +  ++L++Q + +K      ++E L  ++ 
Sbjct: 2207 NLPGMEQLSGASLEKGAL--DTTDGYMGVNQAPEKLDKQCEMMKAR----HQELLSQQQN 2260

Query: 4815 LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4874
              +    A +  D          H  +L P        + +  +Q   GELK   S    
Sbjct: 2261 FILATQSAQAFLDQ---------HGHNLTP--------EEQQMLQQKLGELKEQYST--- 2300

Query: 4875 TVTECESRMVQSIDFQTEMSRSLD-------WLRRVKAELSGPVYLDLNLQDIQEEIRKI 4927
            ++ + E+ + Q    Q E+ + L        WL R + EL        + + +   +++ 
Sbjct: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360

Query: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE---LSELDGDIQEALRTR 4984
                E+V         +SHK   +F         D+E+S  E    SE+   +++ L+  
Sbjct: 2361 GSFSEDV---------ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 2411

Query: 4985 QATLTEIYSQCQRY----------YQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKS 5034
                T ++S+C R           Y  FQ + D L+   +  +     L  ++   +   
Sbjct: 2412 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 2471

Query: 5035 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED---------LEQKVASLELRSQRM 5085
              E  +T  Q    L E    V  L  + +   + +         +++   S+    Q +
Sbjct: 2472 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2531

Query: 5086 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEH 5145
            S     +  LLQ+  AQ    Q++ E +++ + + E+ L E   + + SS   +E L+ +
Sbjct: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATN 2590

Query: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              L   +      + A  E  ++  +T +  + A L   +  V QR+ +L    Q++E  
Sbjct: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            L+  + +   F +   K  + ++     L   +       ++    +      LE+E QQ
Sbjct: 2651 LKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQ---DITHFFQQIQELNLEMEDQQ 2707

Query: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDR 5325
              L  L      +   G A           ++   QDR  N+++      K VK+  KD 
Sbjct: 2708 ENLDTLEHLVTELSSCGFA----------LDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757

Query: 5326 EMVETQINSVKC-------WVQETKEYLGNPTI------EIDAQLEELQILLTE------ 5366
               + Q++  +        W++ET+  +  PT       E++ Q+E L+ LL +      
Sbjct: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGT 2816

Query: 5367 --------ATNHRQNIEKMAEEQKEKYLGLYTILPSELSL-----------QLAEVALDL 5407
                     T+    I ++     +   G  +ILPS  S             L E+  D+
Sbjct: 2817 LVEEINCKGTSLENLIMEITAPDSQGKTG--SILPSVGSSVGSVNGYHTCKDLTEIQCDM 2874

Query: 5408 KIRDQIQDKIKEVEQSKATS-QELSRQIQKLAKDLTTILTKLKAK--------------- 5451
               +   +K+  V   +  S Q +  +++++ K+  ++L  L++K               
Sbjct: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934

Query: 5452 TDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ--NGQLGKPLAKKIGKLTELHQ 5509
            T+ V       K    EL+  + K+ ++  A+   L    N Q  +   K   +L    +
Sbjct: 2935 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2994

Query: 5510 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----VLAHGTIAWNSASQLREQ 5565
            +       R  +L ++ASHL  +      +  W+ + +    VL   +I  N  +  ++Q
Sbjct: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 3054

Query: 5566 YILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEELRQMI 5620
                Q +L+E +    + E + E  Q + +        T ++ +++  + ++  EL   +
Sbjct: 3055 V---QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 3111

Query: 5621 KIRLQNLQDAAKDMKKFEAELKKLQAA-------LEQAQATLTSPEVGRLSLKEQLSHRQ 5673
              R   +  A     +++  L+ L          L    A  T PE    ++K+QL    
Sbjct: 3112 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE----AVKQQLEETS 3167

Query: 5674 HLLSEMESLKPKVQAVQ-LCQS-ALRIPEDVVASLPLCHAALRLQEEASRLQ---HTAIQ 5728
             + S++E L  +V+  Q LC   ++ I E  +          RL+  A  LQ     A  
Sbjct: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD----ELKKRLETVALPLQGLEDLAAD 3223

Query: 5729 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 5788
            + N +QAA+   +Q++Q    L+  ++    +       ++ ++ LQ+Q+  +EE     
Sbjct: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEE----- 3278

Query: 5789 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 5848
              +Q+ +   +   +++   A+  ++LL+V       E    L  +L+   +    +   
Sbjct: 3279 --FQKSLNQHSGSYEVIV--AEGESLLLSVPP----GEEKRTLQNQLVELKNHWEELSKK 3330

Query: 5849 TAGRCHTL----------------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 5892
            TA R   L                L P  E+   + +   ++  P  +  S +  + A +
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAML 3389

Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 5952
            N+     +  S   +   AA I  ++S   E  E G+          + ++ + +   + 
Sbjct: 3390 NE---VEKRRSLLEILNSAADILINSS---EADEDGIRDEKAG----INQNMDAVTEELQ 3439

Query: 5953 EKQRTLYEALERQQKYQDSLQSISTKMEAI--ELKLSESPEPGRSPESQMAEHQALMDEI 6010
             K  +L E  +R +++Q+S ++I  K+E    +L++ ++          + + +A  + +
Sbjct: 3440 AKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499

Query: 6011 LMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEE 6070
              L+ +++ L+ +  + LV ++ +   A QL  Q+   V  +    ++ + +    ++E 
Sbjct: 3500 QALEPQVDYLR-NFTQGLVEDAPDGSDASQLLHQA--EVAQQEFLEVKQRVNSGCVMMEN 3556

Query: 6071 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNML 6130
            KL          + + ++ C   E+ S L      LD   +  ++   +++Q+ D +  L
Sbjct: 3557 KL----------EGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3606

Query: 6131 -------VEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL-RRLKGSLLELQRA 6182
                   ++IE        +      L L G     +   +  GKL  R K    +L+  
Sbjct: 3607 NKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELT 3666

Query: 6183 LHD--------KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ---RQSSL 6231
            L          K LN   TA E+ E+   +  T+   + + LA  +    +Q    Q  L
Sbjct: 3667 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKL 3726

Query: 6232 QQ---------------------QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGD 6270
            QQ                     + ++E+  A   +L + VA R  ++       E    
Sbjct: 3727 QQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL------QEALLH 3780

Query: 6271 AGEKPDVLSQELG--MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV--LY 6326
             G+  D L   L    + E+  A  +       + +    +QKLLQ +L+  +  V  L 
Sbjct: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840

Query: 6327 SRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIHLEQKL 6383
            +   R+     L        D+  +T  L+ L   + E+ S++   ++Q    + L ++ 
Sbjct: 3841 AEGGRIAQSAEL-------ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893

Query: 6384 YDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA 6443
            ++     S +L   E++L  +    P  T+T    Q+I+    K + E+++ +     QA
Sbjct: 3894 HETAEPISDFLSVTEKKLANSE---PVGTQTAKIQQQIIRH--KALEEDIENHATDVHQA 3948

Query: 6444 FP--------ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 6495
                       +   + V+ + +  L  R S +     ++   + + L     F  D   
Sbjct: 3949 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008

Query: 6496 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD------K 6549
            +   LA+    +  KL++VF +   + +   Q A+      +  I+  K+  D      +
Sbjct: 4009 VLNWLAE----VEDKLSSVFVKDFKQDVLHRQHADH--LALNEEIVNRKKNVDQAIKNGQ 4062

Query: 6550 LQVEQPSMQELSKLQD-------MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLL 6602
              ++Q + +E+  +Q+        Y ++ +        L Q   L ++++   ++L   L
Sbjct: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122

Query: 6603 ETGQEKMA--GDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTET---LFRKIISFAVQ 6657
               +E++A  G Q     + E+I Q   + KE  + +  H ++ +T   + R ++     
Sbjct: 4123 REVEEELATSGGQS---PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179

Query: 6658 KETQFHTELMAQAS------------------AVLKRAHK----RGVELEYILETWSHLD 6695
            +  +   +L++ A+                  A ++R+ +       EL ++ ET   L 
Sbjct: 4180 RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLM 4239

Query: 6696 E------DQQELSRQLEVVESSIPSVGLVEENEDRLIDRI-----TLYQHLKSSLNEYQP 6744
                   +Q + + QL+V ++    +   +++ D L         T  +  K+ L E   
Sbjct: 4240 ALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 4299

Query: 6745 KLYQVLDDGKRLLISISCSDLESQ---LNQLGEC------WLSNTNKMSKELHRLETILK 6795
             L Q   +   LL S   + LE     +NQ  E       W+  T  +  +L       +
Sbjct: 4300 SLIQQY-EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358

Query: 6796 HWTRYQSESADLIHWLQSAKDR----LEFWTQQSVTVPQELEMVRDHL----NAFLEFSK 6847
               + Q E   L   +   K      L+   Q     P+E EMV +      N + +  +
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418

Query: 6848 EVDAQSSLKSSVLSTGNQLLRL-KKVD--TATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6904
            EV  ++      +S   Q+     K++    TL +  SR+      +   IPA  +K+ +
Sbjct: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL-----RMPPLIPAEVDKIRE 4473

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG------YKAIHEYLQKYKGFKI 6958
               D   ++ A  E+       E + ++ E+ I  S G       K I + L +   F  
Sbjct: 4474 CISD---NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWE 4530

Query: 6959 DINCKQLTVDFVNQSVLQISSQ--------------------DVESKRSDKTDFAEQLGA 6998
            DI  +    +     VL+++ +                    D+ES   D +   +Q+ A
Sbjct: 4531 DIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEA 4590

Query: 6999 MNKSWQILQGL-----------------------------VTEKIQLLEGLLESWSE--- 7026
                 +   GL                             + E     E L ++W E   
Sbjct: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650

Query: 7027 -----------YENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKAK 7074
                       Y++ +Q +  W +    +L     +G D  +V++ L + ++ +  +  +
Sbjct: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQ 4710

Query: 7075 EKEVEKIEQNGLALIQNKKEDVS-SIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 7133
            + E+EK+   G  +++   ++    I+   L EL   W NL   +   +  L+  L    
Sbjct: 4711 QIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALG 4770

Query: 7134 SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 7193
              + A +++ S+L      L   R ++G  + ++V++     L++D+   + +++     
Sbjct: 4771 QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830

Query: 7194 TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS 7253
             N+LL+        +L + L+ +N  W ++L++  E+ Q  ++ LQ  Q +    +    
Sbjct: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890

Query: 7254 TVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGE-QLKQ 7312
             + + E + +         + A +++ T +    +L   L   +++   L + G   L  
Sbjct: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHM----ELYSQLKAKEETYNQLLDKGRLMLLS 4946

Query: 7313 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 7372
            + D+ + S  +     L Q    +   + ++++ L+  +     F  SL+    W+  AE
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006

Query: 7373 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRM 7430
            + L    P  S  L+T+  ++EE K    + ++    +  L++ G +L      +++  +
Sbjct: 5007 QSLNIASPP-SLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLI 5065

Query: 7431 QNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEIS 7484
            +NL       W  +  ++ ER   L     + + F E  +  +++L   E  L   +EIS
Sbjct: 5066 KNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS 5125

Query: 7485 GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQ 7543
             +   +  Q   H+ FQ  +  +Q +  + I  G+ L E+  + +D  + +  L  + ++
Sbjct: 5126 NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDK 5185

Query: 7544 WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL 7603
            W  V  ++ +R+  ++  +    ++ +  + L  WL +V    ++    V   L     L
Sbjct: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE-PQLAEDQPVHGDLDLVMNL 5244

Query: 7604 FDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE 7663
             D  +  +K   ++ G+  +   +G++L+ ++       ++ +L E+  +W +       
Sbjct: 5245 MDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVS 5303

Query: 7664 QKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL--SQSLPDHHEELHAEQMRCKELENAV 7721
            ++ +L   LK  E     +   LE L   ++ L    +LPD  E L +     KE    V
Sbjct: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363

Query: 7722 GSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNE 7781
                 D+     + + + A    D I+ +   + +++ ++EE+       +Q++   L+E
Sbjct: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423

Query: 7782 WAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQ 7835
                +E  +EL  W+   E+ + Q     I + I+++K      + + EE+   Q +  +
Sbjct: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483

Query: 7836 LQQMGERL------AKASHESKA-----------------SEIEYKLGKVND---RWQHL 7869
            + +  +R       A    +S++                 S+ E K  ++N    RWQ +
Sbjct: 5484 VTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQV 5543

Query: 7870 LDLIAARVKKLKETLVAVQQL 7890
              L   R +KL + L  +++L
Sbjct: 5544 WLLALERQRKLNDALDRLEEL 5564



 Score =  259 bits (662), Expect = 8e-68
 Identities = 674/3768 (17%), Positives = 1459/3768 (38%), Gaps = 469/3768 (12%)

Query: 5161 ALEEKASQLEKTGNDASKATLSRSM----------TTVWQRWTRLRAVAQDQEKILEDAV 5210
            ALE+ A  L+K+ +  S    SR +          T V  + T+L    QD        +
Sbjct: 1883 ALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD--------L 1934

Query: 5211 DEWTGFNNKV---KKATEMID--------QLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259
              W G  N +   K +   ID        Q  + L    AE+  KA+L  L      F+ 
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER--KAQLDALAFDIQFFIS 1992

Query: 5260 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5319
            E  Q  S      +Q L +L +              ++ A+Q     M+++      LVK
Sbjct: 1993 EHAQDLSP--QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA-----LVK 2045

Query: 5320 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5379
               K +     Q+  +  WV + +  L         Q    Q  L+    ++ +++ + +
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGH------QGRTTQQDLSALQKNQSDLKDLQD 2099

Query: 5380 EQKEKYLGLYTILPS-ELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLA 5438
            + + +     T++   E  ++  +  L  +    +++K+ + ++     QE +R  QK  
Sbjct: 2100 DIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKEL 2159

Query: 5439 KDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLA 5498
            ++  T          + +Q +T++    +EL     K+     A+  ++   G  G  L 
Sbjct: 2160 EEAVT----------SALQQETEKSKAAKELAENKKKI----DALLDWVTSVGSSGGQLL 2205

Query: 5499 KKIGKLTELHQQTIRQAE----NRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI 5554
              +  + +L   ++ +      +    +NQA   L++  EM++   +  E      +  +
Sbjct: 2206 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA--RHQELLSQQQNFIL 2263

Query: 5555 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETE 5614
            A  SA    +Q+  H    EE + +  +L  + E  QY TS+  +E   +QV  L  E  
Sbjct: 2264 ATQSAQAFLDQHG-HNLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE-- 2318

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 5674
                        LQ   +D K+FE+ L++ +  LE      +SPE     LK Q S  + 
Sbjct: 2319 ------------LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 2366

Query: 5675 LLSEMESLKPKV---QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCN 5731
            ++S    L+      Q V   +++ +  ++      L    L+   E     H+   +  
Sbjct: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426

Query: 5732 I-MQAAVVQYEQYEQEMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKI 5788
              +   + QY Q++     LQ  ++     +E        S+   LQ Q++  ++L +++
Sbjct: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486

Query: 5789 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVM 5847
              +Q  +  L    +              + E+EG          E   +  +H  S+  
Sbjct: 2487 AEHQVPVEKLQKVAR-------------DIMEIEGEPAPDHRHVQETTDSILSHFQSLSY 2533

Query: 5848 MTAGRCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAER 5906
              A R   L   + + +S +E   S + S       +      +S++  +      +  +
Sbjct: 2534 SLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMK 2592

Query: 5907 LQTDAAKIHPSTSASQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLY 5959
            L+ D A+   S  A++E     +E   S TA     KL ++ + +E L     EK+ +L 
Sbjct: 2593 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2652

Query: 5960 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 6019
            + L + + ++     +S K++      S     G  P+  +      + E+ +  ++  E
Sbjct: 2653 KLLPQAEMFEH----LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQE 2708

Query: 6020 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6079
               +L E LV+E      A  L          +R+  +R   +  ++ ++E+  D    Q
Sbjct: 2709 NLDTL-EHLVTELSSCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQ 2761

Query: 6080 RQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQ 6135
             Q   L  +R        WL  T+ ++     PP E      ++E Q+   +++L +   
Sbjct: 2762 EQ---LDEFRKLVRTFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWAS 2813

Query: 6136 KVVALSELSVHN---ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQ 6191
            K   + E++      ENL++E    T  +++   G +    GS +      H  K L   
Sbjct: 2814 KGTLVEEINCKGTSLENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL--- 2867

Query: 6192 GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRS 6250
             T  + + SDV+L   +  GV             +RQ SLQ     +E+   E  S+L+ 
Sbjct: 2868 -TEIQCDMSDVNLKYEKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQW 2915

Query: 6251 VASRGEEILIQHSA------AETSGDAGEKPDVLSQELGMEGEK-------------SSA 6291
            + S+ EE+L    A       ET     E       EL     K             +  
Sbjct: 2916 LESK-EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2974

Query: 6292 EDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
              Q    W+ + +E +++ +    V    Q Q+  S  +         +      +K  +
Sbjct: 2975 NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM 3034

Query: 6352 TSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEE 6411
              +L  L+     +      A++Q +    K ++        L++  + +      +   
Sbjct: 3035 MGVLGPLS-----IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089

Query: 6412 TETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLD 6469
            T       + + +   E++++++   +   QA  ++   +++++D    +  +G+   + 
Sbjct: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149

Query: 6470 SVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EA 6525
            S ++ +   +K++L++    ++DL+ L   + + + +  +    + EQ + +++    E 
Sbjct: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209

Query: 6526 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNL 6585
            +     GL++  A         D++   Q ++    + Q M+DEL   +  ++S   +N 
Sbjct: 3210 VALPLQGLEDLAA---------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260

Query: 6586 TLKSQYERALQDLADLLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMIL 6643
             + ++ ER    L +  E  +   + +G  ++IV+  E +   +   +E           
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE----------- 3309

Query: 6644 TETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR 6703
              TL  +++      E + H E +++ +A                +  S L +  Q+  +
Sbjct: 3310 KRTLQNQLV------ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQK 3347

Query: 6704 QLEVVESSIPSVGLVEENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKR 6755
                VE  +P +   +     L   +D + L   L   K+ LNE + +  L ++L+    
Sbjct: 3348 YQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407

Query: 6756 LLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6812
            +LI+ S +D   +  +   + +   + T ++  +   LE + +    +Q    ++   ++
Sbjct: 3408 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 3467

Query: 6813 SAKDRLEFWTQ--QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGN 6864
             AK +LE +          + LE +R           +VD   +    ++      S  +
Sbjct: 3468 GAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDAS 3527

Query: 6865 QLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS 6924
            QLL   +V          R++S           ++ KL  +       R   S++     
Sbjct: 3528 QLLHQAEVAQQEFLEVKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580

Query: 6925 LMENV--IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6982
             ++ +  I +D D++++ I  + +  +L K    K+DI   +     + +          
Sbjct: 3581 ELDGMGAIGRDTDSLQSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE---------- 3628

Query: 6983 ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 7042
            E    D      +L A+NK    L      + + LE  L    ++   ++ L       E
Sbjct: 3629 EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAE 3688

Query: 7043 KRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKED 7095
            +    Q  +G +  + N     Q L D    ++++V+ ++      NGL   LIQ+  +D
Sbjct: 3689 EAEALQWVVGTEVEIIN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKD 3743

Query: 7096 VSSIVMS-TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7154
                 +   + E+   W  L+  V Q    L+  L      + A + + S+L +    ++
Sbjct: 3744 CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3803

Query: 7155 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7214
              +  +   + V+ Q+   + LQ  L+ ++ ++    +   ++ +       E +T  L+
Sbjct: 3804 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLE 3863

Query: 7215 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7274
             +  RW  LL + A + +  + +L L +++ + ++  +  +   E +        T    
Sbjct: 3864 SLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3923

Query: 7275 ADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 7334
               ++        D+      V  ++    ++G+ L      +    +     SL     
Sbjct: 3924 IQQQIIRHKALEEDIENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979

Query: 7335 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SD 7385
             ++   C++   L   + +   F +    +  W+ E E+ L         QD  H   +D
Sbjct: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039

Query: 7386 LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTT 7445
               + E +   K  + +       L +    G  + L  +++  ++      ++ SS+  
Sbjct: 4040 HLALNEEIVNRKKNVDQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKAL 4098

Query: 7446 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELF 7500
                + +    + Q+  E+   W+    + E++LA   SG      EQ     QR  EL 
Sbjct: 4099 RTLEQARQLATKFQSTYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL- 4152

Query: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
            + E+   + +L ++    + LLE      R+  +  ++  + Q++ V     QR   ID+
Sbjct: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 4212

Query: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQ 7618
             I++ Q+Y + A+    W+ E     M+ LG  PI L+Q +T    +VQ    +  +R +
Sbjct: 4213 AIQRSQQYEQAADAELAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHK 4269

Query: 7619 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKD 7674
             S         ++  +     +  LQ +   + +++++ S+   E+  +L      + + 
Sbjct: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329

Query: 7675 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLL 7734
            WE  E+ ++  +E+ R    +L     DH E+L  +Q   ++L  ++      + +L  +
Sbjct: 4330 WETYEE-LSPWIEETRALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387

Query: 7735 KDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKE 7791
               L   ++ ++  ++ E+ +  +  + ++  ++  R   + E +++      F +K + 
Sbjct: 4388 GPQLKE-LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 4446

Query: 7792 LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAK 7845
            + E L  + S++      LI   ++K+++   + + A  +  K+Q     L++ GE L  
Sbjct: 4447 MLETLENLSSRLRMPP--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG 4504

Query: 7846 ASH----ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 7901
             S     +  A EI+ KL ++   W+ +      R  K  + L   ++   +M++L T +
Sbjct: 4505 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTI 4564

Query: 7902 AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
               +      IV+D  +       + +Q E    I++ + G+   L    +L  D     
Sbjct: 4565 KDTQD-----IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619

Query: 7962 TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 8021
             + E   ++++   ++  W N+     ER  K+E+  +   ++ D      DWL ++   
Sbjct: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4679

Query: 8022 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLK 8079
                   G      K++L + + F+ +V++   ++E +N Q   + ++  + TD    ++
Sbjct: 4680 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IR 4738

Query: 8080 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 8139
            + + E    W+NL +++     +L+  +    +F+ A + ++ WLT  + +L + +    
Sbjct: 4739 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPIS 4797

Query: 8140 CD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---------- 8186
             D   ++ ++ +    + ++  +   +E +   G +L+E S   DA+ +           
Sbjct: 4798 GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4857

Query: 8187 ----EELDELRRYCQEVFGRVERYHKK----LIRLPLPDDEHDLSDRELELEDSAALSDL 8238
                ++ +E  +  Q    + + +H +    L+ L   + +   S     L ++A    L
Sbjct: 4858 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR-EQL 4916

Query: 8239 HWHDRSADSLLSPQPSSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRD 8294
              H      L + + + N  L   + +   R    SG  T  SV  +  +W        +
Sbjct: 4917 DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEE 4976

Query: 8295 LESAMSRALPSEDEEGQDDKDFY-------------------LRGAVGLSGDH------- 8328
             +S +  AL    E     ++F                    L   +    +H       
Sbjct: 4977 RKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV 5036

Query: 8329 SALESQIRQLGKALDDSRFQIQQT----------------ENIIRSKTPTGPELDTSYK- 8371
            +A   QI +L +  +  +F  Q+                 E +++     G  LD + K 
Sbjct: 5037 NAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKR 5096

Query: 8372 ------GYMKLLG-------------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8412
                   + KL+              E S+  D +K    K KE +++L G   ++ T  
Sbjct: 5097 AKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156

Query: 8413 QTAGVI---------------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNS 8451
            +T   +                     D+W+ +  +++ ++ ++++ L    QF   L +
Sbjct: 5157 RTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQA 5216

Query: 8452 IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ 8511
            +  WL   E +L + Q +    D+    +   K+   QK +  R   +  +     E  +
Sbjct: 5217 LVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIE 5274

Query: 8512 ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 8571
                ++  ++ +L +++ RWD VC L    +  L+ AL Q + F +  H LL  L   ++
Sbjct: 5275 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 5334

Query: 8572 --RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCL 8629
              R    +P D+    + L D HK+ M+   ++ E ++ V S   M  ++++     DC+
Sbjct: 5335 TLRFRGALPDDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCI 5389

Query: 8630 EA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8672
               K  + +I  R + +L    +H + LE  L   V++++  ++L +W
Sbjct: 5390 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 5437



 Score =  225 bits (573), Expect = 2e-57
 Identities = 563/3336 (16%), Positives = 1277/3336 (38%), Gaps = 328/3336 (9%)

Query: 307  NSVQNFKREDRVIFKEMKVWIEQFERDLTRAQM--VESNLQDKYQSFKHFRVQYEMKRKQ 364
            + +QN       + K+++ ++E+ +  L+  ++  +   L    + ++  + +  + +K+
Sbjct: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKE 2158

Query: 365  IEHLI-QPLHRDGKLSLDQALVKQSWDRVTSRLFDWHI-------QLDKSLPAPLGTIGA 416
            +E  +   L ++ + S     + ++  ++ + L DW         QL  +LP      GA
Sbjct: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDA-LLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217

Query: 417  WLYRAEVALREE-ITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGI 475
             L +  +   +  + V Q  E+     +    +H++LL        A          +G 
Sbjct: 2218 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 2277

Query: 476  PVPPDQ-------LEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAE 520
             + P++       L ++ E++    + SE  L +++        FL+      S L  +E
Sbjct: 2278 NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE 2337

Query: 521  SKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA 580
             +L++        E++  LL+   SF E+      ++   + +  + +  +  + S +E 
Sbjct: 2338 KELENMHKGGSSPETLPSLLKRQGSFSED---VISHKGDLRFVTISGQKVLDMENSFKEG 2394

Query: 581  ENVMKFMN-------ETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAE 633
            +   +  N       + T ++  L  +   + S L  ++  + ++ N+  SLQAW++  E
Sbjct: 2395 KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE 2454

Query: 634  KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWREL 693
              +   E    D   + P  +Q+  A         +  +E+    +  + L    R    
Sbjct: 2455 ANV---EKLLSDTVASDPGVLQEQLATTK------QLQEELAEHQVPVEKLQKVAR---D 2502

Query: 694  FMEVKQYAQADEMDRMKKEYTDCVV----TLSAFATEAHKKLSEPLEVSFM---NVKLLI 746
             ME++     D   R  +E TD ++    +LS    E    L + +  S     +++ L+
Sbjct: 2503 IMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560

Query: 747  QDLEDIEQRVP-----------VMDAQYKIITKTAHLITKESPQEEGKEMF--------- 786
            Q + ++EQ +            + +A    +     +  ++S  E  +EM          
Sbjct: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2620

Query: 787  ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLER--- 843
             T + L+ +L +V + +  L  + Q+    L++L  Q   F    GK+ + +    R   
Sbjct: 2621 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2680

Query: 844  ----EAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ----- 894
                  Q    F Q+ QEL    E+ ++ L  +E     +       ++ +H D+     
Sbjct: 2681 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR 2740

Query: 895  ---TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFE---------ESRAELEKV 942
               T LQ+ + +      S  ++  +++K V T  + +K+ E          S  ELEK 
Sbjct: 2741 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2800

Query: 943  LRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF------------------------ 978
            +   +  L++      L+       + L+  ++                           
Sbjct: 2801 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2860

Query: 979  LKACDELTDILPEQEQQGL--QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKN-----RF 1031
               C +LT+I  +     L  ++    LH++ + LQ      +L+   +V K      ++
Sbjct: 2861 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA-----ILNRMEEVHKEANSVLQW 2915

Query: 1032 LASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVR 1091
            L S EE    +D  +     E  +   + ++ F ++   +     ++Q ++E    L V 
Sbjct: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQN---SPKIQKVKEALAGLLVT 2972

Query: 1092 DPVRDTPGTCHVTLKELRAAID-------STYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1144
             P            +EL +  +       +  R+L E       + +  S+   W+   E
Sbjct: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032

Query: 1145 TQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLK-VLT---EVS-SENE 1199
              +  +   +ID       K+ V+ +      R +    L    + +LT   +VS S ++
Sbjct: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092

Query: 1200 AQKQGDELAKLSSSFKALVTLLSEVEKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQ 1258
             QK   EL  ++  +  L   L+     +        QY+E++++  E++ +  + +  Q
Sbjct: 3093 VQK---ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149

Query: 1259 AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ---------GEGGLPDR 1309
            +   + T+     QQL     ++T  I +    +  ++ +AQ          GE  L D 
Sbjct: 3150 S--AISTQPEAVKQQL-----EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202

Query: 1310 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1369
              + L  +   L GLE     +  R+Q  L   ++F+   + +  +L    S   +    
Sbjct: 3203 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 3262

Query: 1370 SS-LESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLG---PQNKQLLQQQAKSIKE 1425
            S+ LE L S+L++ +EF K     +   E +V E   + L     + K+ LQ Q   +K 
Sbjct: 3263 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 3322

Query: 1426 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1485
              ++L     +    ++    K   +  + E L  WI + + +++ L  +   + ++ S 
Sbjct: 3323 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 3382

Query: 1486 I--KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL 1543
            +  K  + E+E + S +  L   A          E   I+ +   I +  + + E  Q  
Sbjct: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDG-IRDEKAGINQNMDAVTEELQAK 3441

Query: 1544 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSA--TETYKVLQEHMDLCQA 1601
             G++     + ++F+E+ + I++ V   + +L +   + S A   +  + L+   ++ QA
Sbjct: 3442 TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA 3501

Query: 1602 LESLSSAITAFS----ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLL--- 1654
            LE     +  F+      A    +    + +A   QQ++ ++ +R       +EN L   
Sbjct: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561

Query: 1655 AHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGE---LQLIQALQNEVVSQAS 1711
              +    +E+ S L  L+       +   D  + + ++E     L  I  L+ ++ +  +
Sbjct: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA 3621

Query: 1712 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
                +L+ + +L  +  K +++ +     +L ER +   + +   +  ++    + +  +
Sbjct: 3622 ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681

Query: 1772 ELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLG 1831
            +   +      L   +    +E+ I++ Q+A  +          +K ++  LQ  L ++ 
Sbjct: 3682 DATTAAEEAEAL---QWVVGTEVEIINQQLADFK--------MFQKEQVDPLQMKLQQVN 3730

Query: 1832 SLGRAEDLHLLQGKAEDC----------------FQLFEEASQVVERRQLALSHLAEFLQ 1875
             LG+     L+Q   +DC                  L ++ +Q + + Q AL H  +F  
Sbjct: 3731 GLGQG----LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF-- 3784

Query: 1876 SHASLSGILRQLRQTVE--ATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKA 1933
               +L  +L  L  T E  A       E  +++  + +     + L+    ++D + ++ 
Sbjct: 3785 -QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843

Query: 1934 QYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKS 1993
                +      R       + L      + +    +Q + + + VL K F +  E +   
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903

Query: 1994 IEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFA 2053
            +   E++             +QQ++     LE+++ +H  ++     +A +I Q   +  
Sbjct: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV----HQAVKIGQSLSSLT 3959

Query: 2054 PEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM-----------REYQNLKSAVSKVL 2102
               ++ +  L    D  +    E Q +CC    L+            +   + + +++V 
Sbjct: 3960 SPAEQGV--LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017

Query: 2103 ENASSVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
            +  SSV V     KD  Q+ L    + H     ++  ++K++D     G+ L   LK+  
Sbjct: 4018 DKLSSVFV-----KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTT 4069

Query: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
              +  L++  ++    ++ D++    + +  L  +  +     ST +E+ GW    + ++
Sbjct: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW----LREV 4125

Query: 2221 AENISNLDNHLRAEELLKEF---ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFI 2277
             E ++         E + +F   + E+K + +    +   VN++      L      + +
Sbjct: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185

Query: 2278 EADLMQKLEHAKEITEVAKGTLKDFTA---QSTQVEKFINDITTWFTKVEESLM-----N 2329
            +  +    E  K +++     + +  A   +S Q E+  +    W  + +  LM      
Sbjct: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245

Query: 2330 CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKH 2389
              Q++T   L+  K    ++   + ++     + + +       +   L      LI+++
Sbjct: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305

Query: 2390 EAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2447
            EA+S L S+  A L+ +  L   F E+ +E   W    +A   +      D + L  +  
Sbjct: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 4365

Query: 2448 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2507
            +++ + +S+++ +  +D + + G  L   L+ +    ++E+  KA   +    ++  +  
Sbjct: 4366 EMRQLRESIAEHKPHIDKLLKIGPQL-KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424

Query: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGEL 2567
             AL +  S+     + H K+   +  +      ENL    +  P    EV K+   + + 
Sbjct: 4425 LALDEAVSQSTQITEFHDKIEPMLETL------ENLSSRLRMPPLIPAEVDKIRECISDN 4478

Query: 2568 LAARESLDK-------LSQRGQLLSEEGHGAGQE------GRLCSQLLTSHQNLLRMTKE 2614
             +A   L+K       L +RG+ L     GA ++           Q++   +++    +E
Sbjct: 4479 KSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4538

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
            +       L+  E     + ++   +K  QD +   ES  G   ++ K+  +  + +  +
Sbjct: 4539 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP-GIDPSIIKQQVEAAETIKEE 4597

Query: 2675 GEG-EVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVIS 2733
             +G   +L      G   + +  +  +  ++  ++ +   W ++  +       LE  + 
Sbjct: 4598 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4657

Query: 2734 QWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL 2793
                Y +    +  W+++   K+         L      L+ ++    E       + +L
Sbjct: 4658 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL 4717

Query: 2794 IAKSRELYEKTEDESFKDTAQE---ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
              +   + +K  DE+ +D  +E   ELK  + ++      +  K+E  +     +  A+ 
Sbjct: 4718 NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
            E   WL   +E L     +SGD    + +L+K   L +      + +  V     E+ ++
Sbjct: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837

Query: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
            +       + + ++A+   W+       + +  L++ + Q      E    + +L +   
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897

Query: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
            Q SA   T     T  E  +T  E           L +  KA+  T +       L   S
Sbjct: 4898 QLSASKPTGGLPETAREQLDTHME-----------LYSQLKAKEETYNQLLDKGRLMLLS 4946

Query: 3031 RDLSTYSGK----VSGLIKEYNCLCLQASKGCQNKEQILQ--QRFRKAFRDFQQWLVNAK 3084
            RD S    K    V+ L ++++ +  +  +     E+ L     F+ + ++F  WL  A+
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006

Query: 3085 ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQ 3144
             +          ++ V + +++ + F +E    + ++  +   G  L  L  K+    I+
Sbjct: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066

Query: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEK------MVHE 3198
              + + +  W+       ++  +L++ + + K F  + + + DWL   E        +  
Sbjct: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126

Query: 3199 SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLS 3258
              +++    +K +E QK     + ++    +  R  ++   L E      +F   + ++ 
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF---LGEVR 5183

Query: 3259 SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML--DSYCHPTSDKSVL 3316
             ++  +   + E+  +L+  +    QF   ++ L DW+      L  D   H   D   L
Sbjct: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD---L 5240

Query: 3317 DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA 3376
                +    +   +  K      ++ R    L   S +    ++ QLQ +   W ++   
Sbjct: 5241 VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKL 5300

Query: 3377 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
             +  +S+LE AL +   ++D V     W+   E  L
Sbjct: 5301 SVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336



 Score =  209 bits (533), Expect = 7e-53
 Identities = 571/3042 (18%), Positives = 1168/3042 (38%), Gaps = 431/3042 (14%)

Query: 5882 PSPVANTDAS----VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFY-EPGLEPSATAK 5936
            PS ++ TD S      Q+  Y  +    + +    +I  S    ++ Y E   +P+   K
Sbjct: 1566 PSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLK 1625

Query: 5937 LGDLQRSWETLKNV----ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5992
            L ++  S    K V     S+++   ++  +   K   +L+S     E    K  E   P
Sbjct: 1626 LEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANP 1685

Query: 5993 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQ---------LAL 6043
                   +A  +A   E ++ Q     L S L E+L     + +   Q         L  
Sbjct: 1686 N------VAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLET 1739

Query: 6044 QSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL----------------EEQRQEQ-ALQ 6086
                TV     S ++ + + + +L E   ++Q                 E  R  Q    
Sbjct: 1740 SEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFT 1799

Query: 6087 RYRC-EADE-LDSWL-LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK---VVAL 6140
            R  C E DE L S+L L     + T    P E    E Q + CQ  ++E E K    +  
Sbjct: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859

Query: 6141 SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEES 6200
             EL   N+ ++ + +       + L    + L+ SL  +    + + L+ Q  A E E++
Sbjct: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN-AVEIEKT 1918

Query: 6201 DVDLTATQSPG----VQEWLAQARTTWTQQRQSS----------LQQQKELEQELAEQKS 6246
             V    TQ  G    ++ W+         +  +S          LQQ ++L+Q +AE+K+
Sbjct: 1919 KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA 1978

Query: 6247 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG----EKSSAE-DQMRMKWES 6301
             L ++A   +  + +H A + S     +   L  EL        E+++A+ D ++   + 
Sbjct: 1979 QLDALAFDIQFFISEH-AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ 2037

Query: 6302 LHQEFSTKQ-KLLQNVLEQEQEQVL--YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGL 6358
            + QE   K  +  QN   Q+ E +     +  R L+G   ++G    QD SA+      L
Sbjct: 2038 MEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG---HQGRTTQQDLSALQKNQSDL 2094

Query: 6359 NQAFEEVSSQSGG-------------------------AKRQSIHLEQKLYDGV-SATST 6392
                +++ +++                           A R+ +H  ++ Y+ +   T  
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154

Query: 6393 WLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD--- 6449
               ++EE     T+ L +ETE     +   AK++ E  +++D   +  +      G    
Sbjct: 2155 AQKELEE---AVTSALQQETE-----KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206

Query: 6450 NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKERLQQILNFQNDLKVLFT 6498
            N   +E   G  L  G L   D    VNQ       +C  MK R Q++L+ Q +  +   
Sbjct: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQ 2266

Query: 6499 S----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ 6554
            S    L  + + +  +   + +Q + E  E   Q    L + +A + +++   D+L   Q
Sbjct: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEAELKQVQTLQDEL---Q 2320

Query: 6555 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6614
              +Q+  + +   +     + +   G +   TL S  +R      D++        GD +
Sbjct: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI-----SHKGDLR 2375

Query: 6615 IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 6674
             +  S    Q++LD    + +G E   I    L +  +  A ++ T  H+          
Sbjct: 2376 FVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATERYTALHS---------- 2420

Query: 6675 KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--GLVEENEDRLIDRITLY 6732
             +  + G  L  +L  +         L   ++  E+++  +    V  +   L +++   
Sbjct: 2421 -KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479

Query: 6733 QHLKSSLNEYQ---PKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHR 6789
            + L+  L E+Q    KL +V  D   + I    +     + +  +  LS+   +S  L  
Sbjct: 2480 KQLQEELAEHQVPVEKLQKVARD--IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537

Query: 6790 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE----------MVRDHL 6839
              ++L+            I   QS ++ LE   Q    V Q LE          ++++ L
Sbjct: 2538 RSSLLQ----------KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEAL 2587

Query: 6840 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 6899
               ++  +++  Q   KSS+ +T   + R  +   +T  + L             +  V 
Sbjct: 2588 ATNMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQ----------GKLAEVS 2634

Query: 6900 EKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--------IHEYLQ 6951
            ++  QL + +     ++ +++    + E++  K +  ++N     A        I  + Q
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQ 2694

Query: 6952 KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT 7011
            + +   +++  +Q  +D +   V ++SS        D     +++  + K +  LQ  V 
Sbjct: 2695 QIQELNLEMEDQQENLDTLEHLVTELSSCGF---ALDLCQHQDRVQNLRKDFTELQKTVK 2751

Query: 7012 EKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLI 7071
            E+ +      E   E+   V+  + W +  E  +           ++  ++  + L D  
Sbjct: 2752 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2811

Query: 7072 KAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQ 7131
             +K   VE+I   G +L         +++M       Q         G+   +L SV   
Sbjct: 2812 ASKGTLVEEINCKGTSL--------ENLIMEITAPDSQ---------GKTGSILPSVGSS 2854

Query: 7132 WSSHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQVQVDNLQNLQDDLEK 7182
              S       +N Y     L E +  +S    ++  L G L   Q  +  + N  +++ K
Sbjct: 2855 VGS-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2907

Query: 7183 QERSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLEEIAEQLQSSK-ALL 7238
            +  S+ ++     ++LK      + T T T+K   E N  +   LE+ + ++Q  K AL 
Sbjct: 2908 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2967

Query: 7239 QLWQRYKDYS-----KQCASTVQQQEDRTNELLKAATNK-----------DIADDEVATW 7282
             L   Y +       K+    +  + +R  E+  A   +             A+ ++  W
Sbjct: 2968 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 3027

Query: 7283 IQDCNDLLKG-----------LGTVKDSLFFLHELGEQLKQQVD---------------- 7315
            + +  +L+ G           L   K  + F+ +  E  +QQ +                
Sbjct: 3028 LME-KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086

Query: 7316 ASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL 7375
            + + S +Q +  S++Q    L   L  + + +   ++    + + L+ L   +    + L
Sbjct: 3087 SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 3146

Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRL-----------NELGYRLP--- 7421
              Q        S I  + E +K Q+ + S +  DL++L           +EL   +    
Sbjct: 3147 SVQ--------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198

Query: 7422 LNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL---QHQTFLEKCETWMEFLVQTEQK 7478
            L D+  KR++ +      +     +R ++LQ+ L    Q Q   ++  TW++   Q++Q 
Sbjct: 3199 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD-KQSQQA 3257

Query: 7479 LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKL 7537
                IS   + L  Q + +E FQ  +         I+ +G+  LL     +++     +L
Sbjct: 3258 KNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQL 3317

Query: 7538 TLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPL 7597
              L N W+ + ++   R+  +   +++ Q+Y+   E L  W +E     MS L     P+
Sbjct: 3318 VELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCKAKMSELRVTLDPV 3376

Query: 7598 QQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ------ 7651
            Q   +L        +V  R+  S +  + +   +L+++    E  ++ E A I       
Sbjct: 3377 QLESSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434

Query: 7652 -EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EELHA 7709
             E+ ++ +  LEE  ++L    + ++  EK +  +  +L  F    SQ+  + + E+L A
Sbjct: 3435 TEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA 3494

Query: 7710 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7769
            +Q   + LE  V  +  + TQ  L++D         D S L  + E+ Q+++ E+  +++
Sbjct: 3495 QQEVLQALEPQV-DYLRNFTQ-GLVEDA----PDGSDASQLLHQAEVAQQEFLEVKQRVN 3548

Query: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI---------------LIEEM 7814
                 +  +L     F  + +E+   L  ++ ++   G I               L    
Sbjct: 3549 SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNK 3608

Query: 7815 IEKLKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHESKA--SEIEYKLG 7860
            I  LK D +   A     + +E        K +L+ + ++  K +   KA   ++E  LG
Sbjct: 3609 IHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668

Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
            +V D ++        ++K L +   A ++ +     + T +  I  +LA   ++     +
Sbjct: 3669 RVEDFYR--------KLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720

Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
             +Q KL +   L + +                      +   D +   ++     ++ RW
Sbjct: 3721 PLQMKLQQVNGLGQGL--------------------IQSAGKDCDVQGLEHDMEEINARW 3760

Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELK 8040
              +     +R  +++E      KF D       WL  +E   A        Y V K +++
Sbjct: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820

Query: 8041 KFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSIL 8100
            + +  QR + +    ++++  +  R+A+         +   +     RW  L  +  +  
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880

Query: 8101 RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SECDVQAKIKQLKAFQQEISL 8158
            ++L+  +   ++F    + I  +L+  + +L N E        +Q +I + KA +++I  
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940

Query: 8159 NHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL------IR 8212
            +   + Q +  G+ L   + P +  ++ E++D L+    E+  R  R    L       R
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000

Query: 8213 LPLPDDEHDLSDRELELED---SAALSDLH---WHDRSADSLLSPQPSSNLSLSLAQPLR 8266
            L   +DE ++ +   E+ED   S  + D      H + AD L   +   N   ++ Q ++
Sbjct: 4001 L-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059

Query: 8267 SERS--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 8324
            + ++   + T   V  I  + D       D+    S+AL + ++  Q         A   
Sbjct: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ--------LATKF 4111

Query: 8325 SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI 8384
               +  L   +R++ + L  S  Q    E I        P+     K   K + E    +
Sbjct: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQKELKKEVMEHRLVL 4163

Query: 8385 DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 8444
            D+V  +   L E    L  +      +   +   ++++L+      +   +   +Q+ QQ
Sbjct: 4164 DTVNEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219

Query: 8445 FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINL 8504
            +    ++  AW+ +T+ +L  L  + L  D  T +LQ++K   +   + H+ ++    + 
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSH 4278

Query: 8505 CSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 8564
             S  F     ++   LQ++   +  +++ +  L  E    L+ A +    F E    L  
Sbjct: 4279 RSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 4338

Query: 8565 MLENIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VN 8622
             +E     +  I  + S  +D E L+   +++ Q++  + E +  +  L  +  QL  +N
Sbjct: 4339 WIE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395

Query: 8623 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
             E  + +E  EK     N    + +EV +    L++ +  S+
Sbjct: 4396 PEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 4435



 Score =  199 bits (505), Expect = 1e-49
 Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)

Query: 503  MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
            +++LE K  +L  +    S  K+        E+V+   ++  +F+      EQ     Q 
Sbjct: 2913 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2961

Query: 563  LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 622
            +K+     +    + +EAEN  K   E  ++W   +    + +  LEE  S+   +    
Sbjct: 2962 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 3021

Query: 623  ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 669
            + L+ WL + E              MLN  +   +   +      QQH  +N+A   ++ 
Sbjct: 3022 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 3081

Query: 670  TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 726
               +  + +  ++++L  +N +W EL  ++  + +Q D+      +Y + +  LS     
Sbjct: 3082 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 3141

Query: 727  AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 780
              ++LS    +S     VK  +++  +I   +  +D + K    +  + + LI ++  ++
Sbjct: 3142 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201

Query: 781  EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
            E K+   T    +  L++            L  +QQ     +EL   +        K   
Sbjct: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 3261

Query: 837  IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
            I   LER  QS     ++ Q+ L   ++      ++ +G         L +V    ++  
Sbjct: 3262 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 3312

Query: 897  LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 954
            LQ Q+ ++   ++ + KKT D +  ++   +  +K++    +L   +   +  + E    
Sbjct: 3313 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 3372

Query: 955  -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1007
             DP +L   L R     +++++R   + L+  +   DIL    E ++ G+++    +++ 
Sbjct: 3373 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 3430

Query: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
               +  E       L+   E  + L   +E    ++++      EG+    K     F  
Sbjct: 3431 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 3478

Query: 1068 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1103
             G      K L+ +      L   +P            V D P                 
Sbjct: 3479 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3538

Query: 1104 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1163
               E++  ++S    +    +    +  R  E  S ++  + +L G+     DT     +
Sbjct: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3595

Query: 1164 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1223
            +  +E++R         L   K  +  L   +SE E +   +E   L      L+ L  E
Sbjct: 3596 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3641

Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1275
            +E +    G   +  +  +  LE  +   ++   + + + D     E  + L        
Sbjct: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701

Query: 1276 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1322
             + +QQ       +K  V     + QQ    G+G +   G +        ++ ++ +  +
Sbjct: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761

Query: 1323 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1380
             L +   ++  ++Q  L    +F+   E ++ +L  T    ++++  S +  + + ++++
Sbjct: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3820

Query: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1438
            + K   +  +      + L  E   I    +  +++ +  Q +S++ +  +L        
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880

Query: 1439 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1495
            K +E +      F    E +S +++  EK+L   E   T ++ +  QI + K   ++IE+
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940

Query: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1554
              + +    +  QS +   +  E   +  K+  ++    E+++   C +  +L   LS  
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3999

Query: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1610
            + F E+  ++   ++E EDKL+            ++   +H+ L + +    +++  AI 
Sbjct: 4000 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059

Query: 1611 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1665
               A  ++    +  +  ++   ++ +Y DI   + +    LE    L   +Q   +EL+
Sbjct: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 4119

Query: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
             +L  +E  E  A+S     + +++    + Q  + L+ EV+        + ++  +L  
Sbjct: 4120 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 4175

Query: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1781
            +      + +   +   +E+++ +   I +R++ + + +   QQ+++   +   W+    
Sbjct: 4176 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 4235

Query: 1782 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1833
                    + L + QTT+++ +     + + RHKD   E+ S + E+          G+ 
Sbjct: 4236 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 4286

Query: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1889
            G  E   +LQ K E   Q +E  S +   R   L      + +F +++  LS  + + R 
Sbjct: 4287 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345

Query: 1890 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1947
             +    S   +   L ++   +  Q  +++      +D +L        L     E    
Sbjct: 4346 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 4404

Query: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
                A+ +  +++           EA + +     F D+ E +L+++E++  R     L 
Sbjct: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464

Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2061
                  +++ +        EL   +     LK + +++      A KD+A A E+  +++
Sbjct: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4523

Query: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2120
            ++   W+D K    E + +   +++L  ++    +A+   +++   ++    +   D   
Sbjct: 4524 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4583

Query: 2121 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2180
            +K      ET K + +   ++L+     G  L+    +    +   V+  ++   + W +
Sbjct: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4640

Query: 2181 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2234
            +++  +E +++L  ++        T   +  W +N V      P +  +++ + + L   
Sbjct: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4699

Query: 2235 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2287
              +KEF+ EV  + + +E+L+        K  D  +     E   +L+ +  +L +K+ H
Sbjct: 4700 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757

Query: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2342
             +   E A   L  F       +  + ++ +W T  EE L     ++         L K 
Sbjct: 4758 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
              ++ ++ + Q+ + +  +  N L       +  SL   +  + +  E+V Q   + +  
Sbjct: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870

Query: 2403 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
            LQ +L+  + F   +++F       ++    S    G  +    +L     +   +   +
Sbjct: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930

Query: 2461 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2519
               + +  +G+  L +       S  ++ +    +++     +  + K  L++  +    
Sbjct: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4990

Query: 2520 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
            F++  ++   W+   E+  N  +      +    + E HKV  F  E+ A R+ + +L Q
Sbjct: 4991 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 5048

Query: 2580 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2632
             G   + LS++     Q+  L   LL S Q+    +++ + E+ RS   A +  +   EA
Sbjct: 5049 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103

Query: 2633 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2692
             + +  W++  +  L          D ++ +LS+ ++     G  +   +  I  G +AL
Sbjct: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 5162

Query: 2693 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
            +      E  + +   L  +++ W  +   SV  Q  LE  +     +++    L  W+ 
Sbjct: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222

Query: 2751 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2810
             V+ ++         L     L+D  +    E    T  +  L    REL E + D++  
Sbjct: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282

Query: 2811 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
               Q +EL T+++ +  ++  K  ++E+ +K   ++ D VH   +WL  A++ L     +
Sbjct: 5283 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 5342

Query: 2870 SGDSSATQKKLSKIKELIDSRE 2891
              D+ A Q  +   KE +   E
Sbjct: 5343 PDDTEALQSLIDTHKEFMKKVE 5364



 Score =  187 bits (475), Expect = 4e-46
 Identities = 548/3186 (17%), Positives = 1207/3186 (37%), Gaps = 458/3186 (14%)

Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED-KPVATSNIQELQAQISRHEELAQKIKGY 5791
            +Q  + Q +  E+E+K L  L+    +E+E    +  S  QE+ AQ+ +   L +  K  
Sbjct: 1837 LQDLLCQAKVLERELKDLTTLVS---QELECVNQIIISQPQEVPAQLLK--ALEKDAKNL 1891

Query: 5792 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5851
            Q+ ++S++       +  ++A   + + + + L + T+ L+G L          +    G
Sbjct: 1892 QKSLSSVSDTWNSRLLHFQNA---VEIEKTKVLNQHTQ-LEGRLQD--------LRAWVG 1939

Query: 5852 RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA 5911
              + +L+        +G+NSEI           V + +  + Q     Q ++  + Q DA
Sbjct: 1940 NKNLILN-------SKGSNSEID----------VDSLNLCLQQYEDLKQPMAERKAQLDA 1982

Query: 5912 AKIHPSTSASQEFYE--PGLEPSATAKLGDLQRSWETLKNVISEK------------QRT 5957
                     S+   +  P         L +LQRS++ +    + +            Q  
Sbjct: 1983 LAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042

Query: 5958 LYEALERQQKY-QDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 6016
            L + L++QQ      L+ + + +   E  L+     GR+ +  ++  Q    ++  LQD+
Sbjct: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAG--HQGRTTQQDLSALQKNQSDLKDLQDD 2100

Query: 6017 INELQSSLA------EELVSES-CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 6069
            I    +S A      E  + E+  +  P E  AL+  L    E+   ++ +    ++ LE
Sbjct: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160

Query: 6070 EKLNDQLEEQRQE----QALQRYRCEADELDSWLLST----------------------- 6102
            E +   L+++ ++    + L   + + D L  W+ S                        
Sbjct: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220

Query: 6103 KATLDTA-----LSPPKEPMDMEAQLMDCQNM-LVEIEQKVVALSE-----LSVHNENLL 6151
            K  LDT      ++   E +D + ++M  ++  L+  +Q  +  ++     L  H  NL 
Sbjct: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL- 2279

Query: 6152 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 6211
                  T +E + L  KL  LK        A  + +L    T Q++ +  +         
Sbjct: 2280 ------TPEEQQMLQQKLGELKEQY-STSLAQSEAELKQVQTLQDELQKFLQ----DHKE 2328

Query: 6212 VQEWLAQARTTWTQQRQ---------SSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
             + WL ++        +         S L++Q    +++   K  LR V   G+++L   
Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388

Query: 6263 SAAETSGDAGEKPDVLSQELGMEGEKSSA--------EDQMRMKWESLHQEFSTK----- 6309
            ++ +   +  E  +++  +L    E+ +A           + M     HQ  ++      
Sbjct: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448

Query: 6310 ---------QKLLQNVL-------------------EQEQEQVLYSRPNRLLSGVPLYKG 6341
                     +KLL + +                   E  + QV   +  ++   +   +G
Sbjct: 2449 WMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG 2508

Query: 6342 DVPTQDKSAVTSLLDGLNQAFEEVS---SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 6398
            + P  D   V    D +   F+ +S   ++     +++I   Q + + + +    + +VE
Sbjct: 2509 E-PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567

Query: 6399 ERLF--VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIED 6456
            + L     ++L     +  L     L +DI      ++  + + ++ F E  D+      
Sbjct: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR-FMETADST----- 2621

Query: 6457 TLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFE 6516
            T   L G+L+ +     Q C Q +E+       ++ LK L       ++  L      F 
Sbjct: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEH--LSGKLQQFM 2672

Query: 6517 QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGS 6576
            +  +  + +  Q +  +  F   I EL      L++E    + L  L+ +  EL      
Sbjct: 2673 ENKSRMLASGNQPDQDITHFFQQIQELN-----LEMED-QQENLDTLEHLVTEL------ 2720

Query: 6577 RRSGLNQNLTLKSQYERAL---QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 6633
              S     L L    +R     +D  +L +T +E+   D        +E ++L+   +++
Sbjct: 2721 --SSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK-DASSCQEQLDEFRKLVRTFQKW 2777

Query: 6634 FQGLESHMILTETLFRKIISFAVQKETQFHTELM---AQASAVLKRAHKRGVELEYILET 6690
             +  E  +  TET    + +  ++K+ +    L+   A    +++  + +G  LE ++  
Sbjct: 2778 LKETEGSIPPTET---SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME 2834

Query: 6691 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVL 6750
             +  D   +          S +PSVG         +  +  Y H    L E Q  +    
Sbjct: 2835 ITAPDSQGK--------TGSILPSVG-------SSVGSVNGY-HTCKDLTEIQCDM---- 2874

Query: 6751 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6810
                        SD+  +  +LG         +   L+R+E + K       E+  ++ W
Sbjct: 2875 ------------SDVNLKYEKLGGVLHERQESLQAILNRMEEVHK-------EANSVLQW 2915

Query: 6811 LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL- 6869
            L+S ++ L+  +  +++ P + E V+    +   F  E++  S     V      LL   
Sbjct: 2916 LESKEEVLK--SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2973

Query: 6870 -KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 6928
                +    +     ++S+W        A Q +L +        + A S++  W+     
Sbjct: 2974 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM---- 3029

Query: 6929 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 6988
                +++ +   +G  +I   +   +  ++    K+          L  ++Q + +   D
Sbjct: 3030 ----EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085

Query: 6989 ----KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 7044
                 +   ++L ++N+ W  L   +  +   ++  +   ++Y+  +Q L        +R
Sbjct: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145

Query: 7045 LKQQHRIGDQA-SVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVM 7101
            L  Q  I  Q  +V+  L++  ++   ++  + EV++ +   + L+++  ++  +   + 
Sbjct: 3146 LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY-LKDELK 3204

Query: 7102 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTG 7161
              L  +      L+ +       L++ L      +  FD++ ++L + +   ++   ++ 
Sbjct: 3205 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 3264

Query: 7162 SLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE--TLTNTLKEVNMR 7219
             LE +Q Q+   +  Q  L +   S +   +    LL    PP  E  TL N L E+   
Sbjct: 3265 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV-PPGEEKRTLQNQLVELKNH 3323

Query: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADD-- 7277
            W  L ++ A++    K  +Q  Q+Y+ + +     ++  + + +EL        +     
Sbjct: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383

Query: 7278 ---EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 7334
                +   ++    LL+ L +  D L    E  E             I+ ++  ++Q++ 
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADED-----------GIRDEKAGINQNMD 3432

Query: 7335 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERME 7394
            A+ + L  +  SL+        F +S + +E  +  A+  L+  D   S   S   + +E
Sbjct: 3433 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN--KNLE 3490

Query: 7395 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSF 7454
            +L+ Q     ++ P +D L                 +N  +     +   ++    L   
Sbjct: 3491 KLRAQQEVLQALEPQVDYL-----------------RNFTQGLVEDAPDGSDASQLLHQA 3533

Query: 7455 LLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILH 7512
             +  Q FLE  +      V  E KL  E  G +       R  E+F   A++      + 
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKL--EGIGQFHC-----RVREMFSQLADLDDELDGMG 3586

Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLS---NQWQGVIRRAQQRRGIID---------- 7559
            +I  D   L  Q Q++D   F  K+ +L       +   R   +  G +D          
Sbjct: 3587 AIGRDTDSL--QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644

Query: 7560 -----SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVF 7614
                  ++ +  + R+   +L    VE  Y  + GL       ++A  L   V  + ++ 
Sbjct: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704

Query: 7615 LRQQGSYILTVEA---------------GKQLLLSADSGAEA-ALQAELAEIQEKWKSAS 7658
             +Q   + +  +                G+ L+ SA    +   L+ ++ EI  +W + +
Sbjct: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764

Query: 7659 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKE 7716
             ++ ++  +L   L    K +  +   L  L   ++ ++   P    ++ + A+    K 
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824

Query: 7717 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 7776
            L+  +      +  L      ++      D   +  ++E L+ +W EL  + + R++Q+ 
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884

Query: 7777 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQE 7831
            + L     F E  + + ++L+  E K++ +  +      I++ I +  K  +E+I     
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR-HKALEEDIENHAT 3943

Query: 7832 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7891
            +  Q  ++G+ L+  +  ++   +  K+  +  R+  + D    +   L + L   +   
Sbjct: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003

Query: 7892 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 7951
            ++   +  WLA +E +L+   V D    + + R+  +   L  +I      V   +   +
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDF-KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062

Query: 7952 VLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF 8011
             LL       T  E   IQ+    +  R+ +I   S +    +E+  +L  KF   Y   
Sbjct: 4063 ALLKQ----TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL 4118

Query: 8012 EDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR 8071
              WL+  E   A             +  ++ +  +++V E    L+ +N+  R L     
Sbjct: 4119 TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178

Query: 8072 TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL 8131
              +   L ++V + N+++  +   +   +  +   I + +++E A D+ L W+ E   +L
Sbjct: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238

Query: 8132 TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 8191
                                    ++L   ++EQ     +  ++K+  +D    ++ +DE
Sbjct: 4239 ------------------------MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274

Query: 8192 LRRYCQEVFGRVERYHKKLIRLPLPD--DEHDL-----SDRELELEDSAALSDLHWHDRS 8244
            L  +  E+FG      K +++        +++      S+R   LE +  L +  W    
Sbjct: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334

Query: 8245 ADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP 8304
                LSP      +L    P         +PA +D   L    +    R L  +++   P
Sbjct: 4335 E---LSPWIEETRALIAQLP---------SPA-IDHEQLRQQQEE--MRQLRESIAEHKP 4379

Query: 8305 SED--------------EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 8350
              D              EEG+  ++ Y +        ++ ++ ++RQ   ALD++  Q  
Sbjct: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKA----ENMYAQIKEEVRQRALALDEAVSQST 4435

Query: 8351 Q-------------TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE---HKL 8394
            Q             T   + S+    P +        + + +  S+   +++L+     L
Sbjct: 4436 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 4495

Query: 8395 KEEEESLPGFVNLHSTETQTAGVIDR-------WELLQAQALSKELRMKQNLQKWQQFNS 8447
            K   E L G       +     + D+       WE ++A+A  +E++    L+  ++F  
Sbjct: 4496 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4555

Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
            D+ ++   + DT++ +  L+   +   I  I+ Q++  + +++  D     +  I +   
Sbjct: 4556 DMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGA 4613

Query: 8508 EFTQA-DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
            +   A    E  +++  + +MN  W+ +    +E    L+DA+     + +    +   L
Sbjct: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673

Query: 8567 ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA-EG 8625
            +N   +   + P+ ++L+   ++D   ++ + K E+ + Q+ +  L      +L  A + 
Sbjct: 4674 DNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDE 4731

Query: 8626 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE--LD 8679
            TD    +E +  + +  + L ++++    +LE  L        + ++L SW +  E  LD
Sbjct: 4732 TDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4791

Query: 8680 TSGSVS 8685
                +S
Sbjct: 4792 AQRPIS 4797



 Score =  128 bits (322), Expect = 2e-28
 Identities = 348/1922 (18%), Positives = 743/1922 (38%), Gaps = 191/1922 (9%)

Query: 481  QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 538
            Q   + ER        EL L ++E    K + L+    A  E++   W++     E + Q
Sbjct: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3706

Query: 539  LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 598
             L ++  F +     +  ++  Q +    +  +++ G   + + +   M E  A+W  L+
Sbjct: 3707 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764

Query: 599  VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDF---------FRN 649
             +V    + L+E + +  ++ + +  L +WL D E+++   +    ++          + 
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824

Query: 650  LPHWIQQHTAMND----AGNFLIETCDEMVSRDLKQQLLLLNGRWRELFME-VKQYAQAD 704
            L   +    A  D     G  + ++ +      +  QL  L  RW EL  +   +  Q +
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884

Query: 705  EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 758
            ++  + K++ +    +S F +   KKL+    V     K+  Q +      EDIE     
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944

Query: 759  MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 816
            +    KI    + L    SP E+G  +   +  L+ + +++++  C    L +  Q L  
Sbjct: 3945 VHQAVKIGQSLSSL---TSPAEQG-VLSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3998

Query: 817  LEELEKQMTSFYDSLGKI-NEIITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 872
                 +      + L ++ +++ +V  ++ +   L +Q H + LA  E   N KK +   
Sbjct: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 4057

Query: 873  EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 932
             K  Q++ K  T   VL       +Q ++  I   +  +   +    + +E   +L  KF
Sbjct: 4058 IKNGQALLKQTTGEEVL------LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 4111

Query: 933  EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 983
            + +  EL   LR  +E L   G          +  +R  E   ++ +   VL+   +   
Sbjct: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 4171

Query: 984  ELTDILPEQEQQGLQEAVRKLHKQWK---DLQGEAPYHL---------------LHLKID 1025
             L +++P + ++GL + V   ++Q+K   D  G+    +                 L   
Sbjct: 4172 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 4231

Query: 1026 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1078
             E  R L ++   R E D+ T +L  Q+     I  H+    +   H       C E++ 
Sbjct: 4232 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 4291

Query: 1079 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-TYRKLMEDPDKWKDYTSRFSEFS 1137
             +++E    L              +   E  + ++S  Y +L         +   + E S
Sbjct: 4292 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 4337

Query: 1138 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1196
             WI      +  +   AID   H ++++  EE+R       E    +   LK+  ++   
Sbjct: 4338 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 4394

Query: 1197 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1248
                    E + QK  +  A++    +     L E     +   +     E +  +LE L
Sbjct: 4395 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 4454

Query: 1249 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
             S  +    +  + +KI   E + + +   +  ++      A KR  ++ I ++Q  +  
Sbjct: 4455 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512

Query: 1306 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1354
            L  +   ++L ++    + ++   E +E +    L   E+F         T K+T  +V 
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572

Query: 1355 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1414
             L   G   +  +    +E+  +  E+T    +  E I +   +L+    E       K 
Sbjct: 4573 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4630

Query: 1415 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1468
            +       +   K+ KE+++KLED ++  ++  + ++  +D   +    L          
Sbjct: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4682

Query: 1469 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1526
            +  + T  + +  Q++++K    E+  +   +  L  + +   +   T E+ R  I+  L
Sbjct: 4683 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4741

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
            T+++   E L E     +  + G L    +F+  L ++   ++  E+ L     I     
Sbjct: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801

Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1640
                 L +H  L   + +  + +   + +  +++      +  S      A+ Q +E +L
Sbjct: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861

Query: 1641 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1700
            ++ +ER+  L++ L   Q    E+  FL  L R E++ S+ +          E +L    
Sbjct: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4920

Query: 1701 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1757
             L +++ ++   Y++LL   +    + S+DD       +  +  L+++W  +   + +R 
Sbjct: 4921 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4978

Query: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1815
            + L+  +    +F   L  F  W+ L    L   S  S++ + V   +  HK  A EV +
Sbjct: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038

Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1871
             + ++  L     +L  L + +D+ L++         +E+  Q  +ER R L  A     
Sbjct: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098

Query: 1872 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1931
            +F ++   L   L      +++   ++ N+ D I+  L+   +  K L       D  + 
Sbjct: 5099 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157

Query: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1987
              +  LK  +     S +   D   GEV ++   + G    +Q + +   +    F D  
Sbjct: 5158 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214

Query: 1988 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2047
            + L+  +  +E +  +++        +   +      + EL      +  LK   +++ +
Sbjct: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 5274

Query: 2048 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
                    V  ++  L   WD   +L    Q +    +     +++    + + L  A  
Sbjct: 5275 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 5334

Query: 2108 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2166
             +  R  + D  E L+     H+    K+  K+ D+++  + G+ +L+     H    + 
Sbjct: 5335 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 5391

Query: 2167 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2222
            +K  +     ++ +V    +++  RL  +LS         +E+  W        + +  E
Sbjct: 5392 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 5451

Query: 2223 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2276
             I  N+D   R + L+ E ++        +EE+  K  D+  +T     KN+E P    F
Sbjct: 5452 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 5500

Query: 2277 IE 2278
            IE
Sbjct: 5501 IE 5502



 Score =  117 bits (292), Expect = 7e-25
 Identities = 325/1902 (17%), Positives = 768/1902 (40%), Gaps = 237/1902 (12%)

Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT------VDFVN 6971
            +++S++SL+ N+  + +      +    + + L + K  + ++  K LT      ++ VN
Sbjct: 1809 KLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLEREL--KDLTTLVSQELECVN 1866

Query: 6972 QSVL----QISSQDVESKRSDKTDFAEQLGAMNKSW--QILQGLVTEKIQLLEGLLESWS 7025
            Q ++    ++ +Q +++   D  +  + L +++ +W  ++L      +I+  + +L   +
Sbjct: 1867 QIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK-VLNQHT 1925

Query: 7026 EYENNVQCLKTWFETQEKRL--KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
            + E  +Q L+ W   +   L  K  +   D  S+   L+  +DL+  +  ++ +++ +  
Sbjct: 1926 QLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985

Query: 7084 NGLALIQNKKEDVSSI----VMSTLRELG--------QTWANLDHMVGQLK-----ILLK 7126
            +    I    +D+S      ++  L EL         QT A +D + G L+      L+K
Sbjct: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045

Query: 7127 SVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 7184
            ++  Q ++     + + S++ +A  +L+  + R     L A+Q    +L++LQDD++ + 
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRA 2105

Query: 7185 RSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY 7244
             S           ++E    ++      L+E        L +  EQ ++ +   ++ Q  
Sbjct: 2106 TSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKEQYEALQEETRVAQ-- 2156

Query: 7245 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 7304
            K+  +   S +QQ+ +++    + A NK   D  +        D +  +G+    L    
Sbjct: 2157 KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DWVTSVGSSGGQLLTNL 2208

Query: 7305 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 7364
               EQL        A       + ++Q    L++     +   Q  +   + F  + ++ 
Sbjct: 2209 PGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSA 2268

Query: 7365 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLND 7424
            +A++ +    L  ++         +Q+++ ELK Q                    L  ++
Sbjct: 2269 QAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY----------------STSLAQSE 2306

Query: 7425 KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEIS 7484
             E+K++Q L                +LQ FL  H+ F    E+W+E   ++E++L     
Sbjct: 2307 AELKQVQTLQ--------------DELQKFLQDHKEF----ESWLE---RSEKELENMHK 2345

Query: 7485 GNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-----DDRDEFN 7534
            G         LL++Q +   F  ++ S +  L  + I GQ++L+         +  +  N
Sbjct: 2346 GGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402

Query: 7535 L---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL----VEVSYLPM 7587
            L   KL   + ++  +  +  +    ++  + Q+ +++  A+ L+ W+      V  L  
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462

Query: 7588 SGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAE 7646
              + S P  LQ+   L    Q +E++   Q     L   A   + +  +   +   +Q  
Sbjct: 2463 DTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520

Query: 7647 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK-----KKLSQSLP 7701
               I   ++S S  L E+   L   +   +  ++ +   L+ +   +     K++S    
Sbjct: 2521 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2580

Query: 7702 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD---ISILNERVELLQ 7758
               +E  A  M+ K+            + L   ++ ++ ++   D    ++L  ++  + 
Sbjct: 2581 GVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2634

Query: 7759 RQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL 7818
            +++E+LC Q   +   + + L +  +F   + +L +++ + +S++  +G+   +++    
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRMLASGNQPDQDITHFF 2693

Query: 7819 KK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7876
            ++  +   E+   QEN   L+ +   L+         + + ++  +   +  L   +  R
Sbjct: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2753

Query: 7877 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRD- 7935
             K        + +  K + + + WL   E  +  P    S +++E+++++   + L  D 
Sbjct: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKELEKQIEHLKSLLDDW 2811

Query: 7936 ------IEKHSTGVASVLNLC-EVLLHDCDACA------------------TDAECDSIQ 7970
                  +E+ +    S+ NL  E+   D                       T  +   IQ
Sbjct: 2812 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871

Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT--AAFPSSS 8028
                +++ ++  +  +  ER+  ++      ++   + +    WL+S E    +    SS
Sbjct: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2931

Query: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRTDSACSLKQMVHEGNQ 8087
                   K + +  +AF  ++ +   +++ + +    L      +  A + K++  E N 
Sbjct: 2932 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2991

Query: 8088 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL---------TNIEHFS 8138
            RW+   +   +  R+L+        F+ A   +  WL E +L +          N+ +  
Sbjct: 2992 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051

Query: 8139 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8198
            +  VQ  +K+ +A +Q+    H ++ +  AQG         L  + +++EL  + +   E
Sbjct: 3052 KQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTSQVQKELQSINQKWVE 3106

Query: 8199 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS-NL 8257
            +  ++     ++ +  +   ++    ++L  +  A    L     S  S +S QP +   
Sbjct: 3107 LTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-----SVQSAISTQPEAVKQ 3161

Query: 8258 SLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRDLESAMSRALPSED-E 8308
             L     +RS+        ++     D + +     Y   +L + LE+    ALP +  E
Sbjct: 3162 QLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV---ALPLQGLE 3218

Query: 8309 EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI-IRSKTPTGPELD 8367
            +   D+   L+ A+  +     +  ++R     LDD   Q QQ +N  I +K        
Sbjct: 3219 DLAADRINRLQAALASTQQFQQMFDELRTW---LDDK--QSQQAKNCPISAKLERLQSQL 3273

Query: 8368 TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ 8427
               + + K L + S S + +      L     S+P      + + Q   + + WE L  +
Sbjct: 3274 QENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGEEKRTLQNQLVELKNHWEELSKK 3330

Query: 8428 ALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKE 8487
               ++ R+K  +QK Q++   +  +  W+ D + ++ +L+   ++ D   +E  + + K 
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKA 3387

Query: 8488 LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD 8547
            +   V+ R++++  +N  +     +   +   ++D  + +N   D V   L+   G L++
Sbjct: 3388 MLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447

Query: 8548 ALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES-Q 8606
               + + F E    +    + ++  K+++   D+ L ++   + + + ++ + E+L++ +
Sbjct: 3448 MTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALE 3503

Query: 8607 LRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----- 8660
             +V  L++ +  L+ +A +G+D  +   +  V       + + V+     +E  L     
Sbjct: 3504 PQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQ 3563

Query: 8661 ------DVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQ 8696
                  ++ S   DL      DELD  G++    GR T + Q
Sbjct: 3564 FHCRVREMFSQLADLD-----DELDGMGAI----GRDTDSLQ 3596



 Score = 49.7 bits (117), Expect = 1e-04
 Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)

Query: 296  DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 352
            +E L     F NS+Q F             W+   E+ L  A    ++ + +  + +  K
Sbjct: 4982 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030

Query: 353  HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 403
             F  +    R QI  L Q  ++   LS  Q +V         +  W++V  R  +    L
Sbjct: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090

Query: 404  D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 457
            D      K        +  WL  AE  L  E+ +    ++    I+ +L +HK+  +   
Sbjct: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 5146

Query: 458  AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 501
              +  +    RT R++    + P+        L ++ +++  V   S        E  L 
Sbjct: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 5206

Query: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
              +F++    L+  L   E +L      +G  + V  L+  +  F    K   +   T Q
Sbjct: 5207 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 5263

Query: 562  ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 621
            +LK++    +  + S ++   V   + E + +W  +     S +S LE+ +   + + +T
Sbjct: 5264 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321

Query: 622  VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 665
            V  L  WL +AE+ L       + +E      +  K+F + +    ++   +N A   G 
Sbjct: 5322 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 5378

Query: 666  FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 720
             ++  C       +K  + ++  R+ E+    KQ+ Q       E+    +   + +  +
Sbjct: 5379 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 5438

Query: 721  SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 772
                T   ++  EP+  +   VK LI +    +E++ ++ P +D   K   +      H 
Sbjct: 5439 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 5498

Query: 773  ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 828
               E  +  G++  +  +     +    E  +P + +     QQ+ +   E ++++    
Sbjct: 5499 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5558

Query: 829  DSLGKINE 836
            D L ++ E
Sbjct: 5559 DRLEELKE 5566


>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform 4
            [Homo sapiens]
          Length = 556

 Score =  337 bits (863), Expect = 4e-91
 Identities = 228/594 (38%), Positives = 315/594 (53%), Gaps = 65/594 (10%)

Query: 8229 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8288
            +ED   +    W  R      S +PSS  SL        ERSG +TP SVDSIPLEWDH 
Sbjct: 1    MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56

Query: 8289 YDLS------RDLESAMSRALPSEDEEGQDDKDFYLR---GAVGLSGDHSALESQIRQLG 8339
             D+        D E     AL   D E  ++ + YL+     +  S   S  +     + 
Sbjct: 57   GDVGGSSSHEEDEEGPYYSAL--SDVEIPENPEAYLKMTTKTLKASSGKSISDGHSWHVP 114

Query: 8340 KALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKE 8396
             +        +Q E   R+  P  P   T YK   G + L        +  + L    ++
Sbjct: 115  DSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQ 173

Query: 8397 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8456
            E+  L G         Q +G  DRWE++QAQ L  +L++KQNLQ   Q NSD+++I  WL
Sbjct: 174  EDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWL 224

Query: 8457 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 8516
              TE ELE L+  +  +DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S E
Sbjct: 225  KKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPE 284

Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG--------------FHEMSHGL 8562
            S +LQ RL Q++  W+     ++ WRG L+ +LMQCQG              FH++S  L
Sbjct: 285  STELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNL 344

Query: 8563 LLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 8622
            LL L +   R+ +    D   D   L +  ++LMQ++ EL+E Q +V  LQ++S  LL+ 
Sbjct: 345  LLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIK 404

Query: 8623 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSG 8682
              G DC+EA+EKVHVI  +LK L ++VS      + L+ +  +Q   S   S DE+D SG
Sbjct: 405  GHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SG 457

Query: 8683 SVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLF 8742
               P +    P R K  R                 R+T+G  ++    PG  R  R FL 
Sbjct: 458  DQPPATSVPAP-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRSFLS 501

Query: 8743 RVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
            RV+RAALPLQLLLLLL+ LACL+P SEEDYSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 502  RVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555



 Score = 40.0 bits (92), Expect = 0.10
 Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)

Query: 5909 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5968
            TD  K  P         E G     T +       WE ++   +++     +  +  Q+ 
Sbjct: 157  TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213

Query: 5969 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 6023
               + +I+T ++  E     LK+++ P   +  E ++   Q ++      +  +  +  S
Sbjct: 214  NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273

Query: 6024 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6083
              E L +ES E+   +    Q +L   A +   +     G RQ L +    +   +    
Sbjct: 274  SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332

Query: 6084 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
              + +   +  L  WL S K     A +    + P+  ++   +LM  +  LVE + +V 
Sbjct: 333  FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392

Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6193
             L E+S    +LL++G      EAE+   K+  ++  L +L+  +    + +QGT
Sbjct: 393  MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441



 Score = 36.2 bits (82), Expect = 1.5
 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)

Query: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7918
            DRW+ +         K+K+ L   QQL+ ++S++ TWL   E+EL     AKP      +
Sbjct: 190  DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242

Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASV 7946
             +EI+ ++   QE+ +  + +   V SV
Sbjct: 243  IQEIELRVKRLQEILKAFDTYKALVVSV 270


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score =  317 bits (811), Expect = 4e-85
 Identities = 628/3216 (19%), Positives = 1229/3216 (38%), Gaps = 521/3216 (16%)

Query: 21   LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
            ++DE+E VQK+TFTKW+N+  +K     + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 1    MEDEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKG 59

Query: 81   RRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTS 140
                R+HA+ N+  AL+ L+   + LVNI STDI DG   + LGL+W IIL++Q++ +  
Sbjct: 60   ST--RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMK 117

Query: 141  NLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEV 200
            N+                             +    Q N++K LL WV+ +      + V
Sbjct: 118  NI-----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNV 148

Query: 201  KDFGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPE 259
             +F  SW  G+A +++IH+ RP+L D  +V   +S  + LE AF IA  +LGI +LLDPE
Sbjct: 149  INFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPE 208

Query: 260  DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
            DVD   PD+KSI+ Y+    +  P     S +  ++ E+LP  P          +E+   
Sbjct: 209  DVDTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQ 259

Query: 320  FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLS 379
                  + +Q    L +     S+ + +++S+ + +  Y              H      
Sbjct: 260  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL----- 314

Query: 380  LDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETA 439
              +A   +S+    S L +  + LD+   A L  + +WL  AE  L+ +  +        
Sbjct: 315  --EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDV 364

Query: 440  NTIQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE 497
              ++ +   H+  + +  AH+     I +  ++ +    +  D+  ++ E+ + ++S  E
Sbjct: 365  EVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWE 424

Query: 498  -LHLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQN 542
             L +  ME     +R+L  L   + K L  W+ K   R             E +++ +Q 
Sbjct: 425  CLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQ 484

Query: 543  YVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVE 600
            +    E+    EQ +V    L     +  ++ G    A  E  +K + +   +W N+   
Sbjct: 485  HKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRW 538

Query: 601  VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 660
                  +L++++  W R         AWL + E  +N+                  HT  
Sbjct: 539  TEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTG 581

Query: 661  NDAGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTD 715
                N ++ +  ++  +  DL   KQ +  L    ++L   +K  +   + +     +  
Sbjct: 582  FKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFAR 641

Query: 716  CVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITK 775
            C              L + LE S   +   +   +    +  VM+    + T+   L+  
Sbjct: 642  C-----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH 690

Query: 776  ES-----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYD 829
                   P  + K      S+++++L   + E +S +      L  P   + ++  +F D
Sbjct: 691  AQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSD 750

Query: 830  SLGKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEK 874
               K+N I          + +    + AL +Q   E +       A ++   + +   + 
Sbjct: 751  LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 810

Query: 875  GSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK---- 930
             S+ +      +N++  ++Q +   Q+      +  +   T      +++  ++ K    
Sbjct: 811  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 870

Query: 931  KFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTD 987
            +    + ++E+ L+I    L+EKG     L      F+   ++V   + A  K    + D
Sbjct: 871  RLSGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 929

Query: 988  ILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-E 1045
             LP    Q    A+R     W   Q E    +  L + D E       +E+   EL   +
Sbjct: 930  TLPPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQ 978

Query: 1046 TKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTL 1105
            + L  Q+     +       S K P  +  K     EE+                     
Sbjct: 979  SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRW 1021

Query: 1106 KELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-K 1164
            K+L + +    +KL E  +K +   +       W++  +  LK    E        E+ K
Sbjct: 1022 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILK 1077

Query: 1165 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1224
            + +++ R  V+     +  ++  L  + E   + + + + +  ++L +  K L T    +
Sbjct: 1078 KQLKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1133

Query: 1225 EKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF--------------- 1269
             + +         KE +K  LE+ +S  K++ E  E +   E  +               
Sbjct: 1134 CQQV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1187

Query: 1270 ---EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLER 1326
               E ++     QQK  ++      V   IAQA       P    E L+K   TL     
Sbjct: 1188 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL----- 1235

Query: 1327 SRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFS 1386
                       T  +W     N +   + L +  +     LS+  LE  +  L + +   
Sbjct: 1236 ----------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKL 1281

Query: 1387 KRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1446
            K TE+I   AE    E SE+    +N   L + ++    Q++ L  TL +     E++  
Sbjct: 1282 KTTENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINE 1334

Query: 1447 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEE 1506
            + + F S +  L      ++K L     S+   +  +  I+ ++  I+ +L++ +  + +
Sbjct: 1335 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1394

Query: 1507 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR-- 1562
            A    Q     E+ +I++ LT      EE+++H Q  E    +L  +   QK  +++   
Sbjct: 1395 AAQMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449

Query: 1563 -KIQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSS 1607
             ++ Q  + FE +L         +K+   A ET  V QE         ++L ++L  + S
Sbjct: 1450 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1509

Query: 1608 AITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLE 1661
             +     + R++V      N     +   AL+  Y ++  +  ER+  LE  L   +++ 
Sbjct: 1510 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1569

Query: 1662 KELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKE 1721
            KE++    WL   + + +     +      ++ E+   +A Q E+  Q      + ++ E
Sbjct: 1570 KEMNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGE 1628

Query: 1722 SLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI 1781
            +L +V  K +  +++  L  L+  W  +     + +N L       + FD+ +   + WI
Sbjct: 1629 ALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1687

Query: 1782 KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHL 1841
                + L  + +      +  L R K   AE+   + ++ S +   A           +L
Sbjct: 1688 IQADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NL 1733

Query: 1842 LQGKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTV 1891
            +  + + C +L E     +  R  A+SH          L E  Q ++ +  +L  L    
Sbjct: 1734 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--A 1791

Query: 1892 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1951
            E    +N  E D   KD+N+   N   ++      D +        +I    +R   +  
Sbjct: 1792 EIQQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIK 1842

Query: 1952 ADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTR 2011
               L  +   +++L   ++ +A  ++     ++ Q ++LLK ++DIE++     L EP  
Sbjct: 1843 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRD 1900

Query: 2012 QALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINRLEVT 2066
            +      R   +++ EL   + EL  ++ +A+ +++   A A E     + +    +E  
Sbjct: 1901 E------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESK 1954

Query: 2067 WDDTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI----- 2115
            +   +RL    IH  + +   ++  D+  E   + S     + + S  ++    +     
Sbjct: 1955 FAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD 2014

Query: 2116 ---KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFSLVKT 2169
               KD EDL   F + E+ KN  +  Q+    +D   SK    L     +         +
Sbjct: 2015 LCAKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2071

Query: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NISNLD 2228
             ++    +W  V++  ++   R   S+  W            W       + +  I    
Sbjct: 2072 QLDF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW 2128

Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIEADLM 2282
             H + +  LKE +  +  +   +  L++   ++ + +         E    L     ++ 
Sbjct: 2129 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2188

Query: 2283 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNETCEA 2338
            ++L   K+  E  K  L +F       ++ +N+   W  + +      L    + +  E 
Sbjct: 2189 KQLSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQLKEK 2241

Query: 2339 LKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKKHEAV 2392
            L++VK + +EL  +Q  +    E      +++        +LE+ L +     IK   A+
Sbjct: 2242 LEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL 2301

Query: 2393 SQLCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQ 2450
             +   + +A +++   LEK   +  ++     L       +       +   +    D+Q
Sbjct: 2302 PEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQ 2358

Query: 2451 NILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQAL 2510
                +V   Q  ++ +  +GQ LY    K     ++ ++   + E++A + + L++ +A 
Sbjct: 2359 ETEIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQELRAK 2415

Query: 2511 Q-DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL- 2568
            Q D A  L +                    T+ +    Q +  K+  + K+EM    +L 
Sbjct: 2416 QPDLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSSLMLE 2460

Query: 2569 ---------AARESLDKLSQRGQLLSEEGHGAG--------------------QEGRLCS 2599
                     A  E  D LS   Q++  +    G                    Q      
Sbjct: 2461 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 2520

Query: 2600 QLLTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWFWVKA 2642
            +L+T+ QNL   T             E++++    +QEH     + L E L+    W++A
Sbjct: 2521 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 2580

Query: 2643 IQDRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKG 2688
             ++    AE  LG              + D ++K++++ + +     + +  +++A    
Sbjct: 2581 KEE----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2636

Query: 2689 EQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQW 2748
             + LR  + +  R +    E +   W  I       ++ LE        +     +   W
Sbjct: 2637 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2696

Query: 2749 MESVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE 2799
            +   +          + E  L+   G+KE   L+   Q +  E E HT   H L   S++
Sbjct: 2697 LTEAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDENSQK 2753

Query: 2800 LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYLDAVH 2850
            +    E        Q  L     D M     ++RK    ++ HL         ++L ++ 
Sbjct: 2754 ILRSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL-SLQ 2807

Query: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRLSRVE 2901
            E   WL    +EL R + + GD  A QK+           K KE +    +   R+   E
Sbjct: 2808 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2867

Query: 2902 --------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQTQSC 2943
                           L PE + QN T       E ++TE + L      W+  + +T   
Sbjct: 2868 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET--- 2924

Query: 2944 LENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2979
            LE L        QE      +L+  L Q   +  +W
Sbjct: 2925 LERL--------QELQEATDELDLKLRQAEVIKGSW 2952



 Score =  215 bits (547), Expect = 2e-54
 Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)

Query: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
            ++ L+ +    Q  + Q++++G      ++   ++    QL   W+     +S+ L+   
Sbjct: 766  FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 816

Query: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
                 W  YQ+      + LQ  +      E W +   T P E   ++  L    +   E
Sbjct: 817  -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 868

Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
            V+  S L+  +     Q + LK+       L ++     + +  + +++ A +++L  + 
Sbjct: 869  VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 927

Query: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
             D LP    +  +S + +W+   E  +   + ++ +   Y+ + + L + +  +  +  +
Sbjct: 928  FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 984

Query: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
            Q  + +++ +V ++S +   E  R  +++F E  G     W+ L   + E  Q LE  + 
Sbjct: 985  QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1040

Query: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
               + +N++Q LK W    +  LK++   +GD   ++  LK C+ L   I+  +  +  +
Sbjct: 1041 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1100

Query: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
             + G  +    + + +S + + L+EL   W ++   V   K  LK  L++  S +    +
Sbjct: 1101 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1160

Query: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
            ++ ++ +A            + + +Q  V+ ++  +++ +++E  ++      N ++ + 
Sbjct: 1161 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1220

Query: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
             P   E L   L+ +   +  L   +  + ++ + +   W     Y ++    + + E +
Sbjct: 1221 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1280

Query: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
                LK   N     +E++  +    +L++     +D+   +  L + L    D      
Sbjct: 1281 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1330

Query: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +++L + +     L +   ++Q  L+  +   +   KSL  ++  +   ++ L     
Sbjct: 1331 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1389

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
            +   D + + +  ++++  +        ++ + N   E   R L   D   K++Q+++  
Sbjct: 1390 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449

Query: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
            + L      ++ +  +  L + +  L++ +  +          A+E     Q +++ Q  
Sbjct: 1450 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1495

Query: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
            H   L+++    + ++   +I  G++++++ Q ++  E + ++T L   +  +  +  +R
Sbjct: 1496 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1554

Query: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
            +  ++  ++  ++ R+    L +WL   ++     S +  +P  L  +   + +   KE 
Sbjct: 1555 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1612

Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
              + +Q  ++ ++    + L +     E  ++ +L+ +   W + + R EE    L    
Sbjct: 1613 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1670

Query: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
            K  E  ++ +         AD+L  L   +KK  Q   D  + L AE     ++   V S
Sbjct: 1671 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1725

Query: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
              D    L   +      +    IS LN R       +  + H++   +  I   L E  
Sbjct: 1726 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1776

Query: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
             F   N ++ + L  +E+++ Q  ++  E+  + + +D +  +        +L Q G+ L
Sbjct: 1777 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1826

Query: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
              + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L 
Sbjct: 1827 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1886

Query: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
             IE +LA  P   D    +EI R+L +++E    + + + G++             D  A
Sbjct: 1887 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1934

Query: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
               E   IQ     L +RWR I    +  RRL         EET  +  +          
Sbjct: 1935 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1989

Query: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
              +L + +     L   E+    P      +    E+L K E   + + + L Q    ++
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2045

Query: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
            +I+ +     +         L++ + + + +W+ + K       R    + +   F    
Sbjct: 2046 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2105

Query: 8118 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
                 WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++
Sbjct: 2106 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2164

Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8234
            S   DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2224

Query: 8235 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8291
            ++ +         L        L    L L Q +  + +    P  V S P+  +    L
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2283

Query: 8292 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 8338
               L+        +SRALP    E Q + +  ++    L      LE Q+  L       
Sbjct: 2284 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2339

Query: 8339 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 8381
                    +   +  F +Q+TE  +++K P   E+            + +   + L + S
Sbjct: 2340 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2399

Query: 8382 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 8440
            S   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L M  +L 
Sbjct: 2400 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2458

Query: 8441 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 8498
                  +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + ++ R+  
Sbjct: 2459 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2518

Query: 8499 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 8552
            +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L+D+    
Sbjct: 2519 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2578

Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
            +   E    L      ++  K     +D+      +Q    +  Q+  +L + Q  V   
Sbjct: 2579 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2632

Query: 8613 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
             D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2633 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2677



 Score =  195 bits (496), Expect = 1e-48
 Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
            +L +    L  ++    ++  W+   E+    +  GE    +   K++ H  E ++ +L 
Sbjct: 325  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 382

Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
            A +  +  + Q G  L   G  +  E       +    NLL    E LR   +  Q   H
Sbjct: 383  AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 438

Query: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
              L     + L+ +  W+   ++R    E      D LE    Q+Q   +++ + E   V
Sbjct: 439  RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 497

Query: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
            ++N           SS       ++ QL+ L + WA+I   +      L+ ++ +W    
Sbjct: 498  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557

Query: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
            E +     W+   +  +        G K++  +L  LQ +    ++ E   +++ +L + 
Sbjct: 558  EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 615

Query: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
             ++L    +++S      ++ +   ++        ++K+E+          +  + +  +
Sbjct: 616  KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 661

Query: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
             + +  L + + M   ++ T ++   +K   +       +  R  ++  E+++       
Sbjct: 662  TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 721

Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
            EL H+ +    A  +  E ++F+ +    +L  ++   E+E + +  +L+ A     AL+
Sbjct: 722  EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 780

Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
            +         EG N D                    +  +E L S+  E C+   +   +
Sbjct: 781  EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 817

Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
                + +I  YN L            Q L+Q    A    + WL     T       P  
Sbjct: 818  LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 854

Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
             + + + L+  ++ ++     Q ++  +      + ++  KEK +G   + A   A    
Sbjct: 855  PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 909

Query: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
            +K   S++  +E  L+ +   +    ++ +   I+ W+  S+T+  + + S   Y++  +
Sbjct: 910  FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 969

Query: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
            R  E Q LQS L+E    ++     +  + +KA         S+ ++    ++  ++  L
Sbjct: 970  RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1024

Query: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
            S+   E   +L+  + +  +    I+ L+ WM +    L        D  +L  +  +  
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1084

Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
             L+S  Q  +  +  +   G+ +     PE    ++ +L+ +   W  +       K  L
Sbjct: 1085 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1144

Query: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
            +G L K  S Q  + +   WM                 D ++  + E +R   E + K  
Sbjct: 1145 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1203

Query: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
               K KLL E V S         +  A        + EL+ L   Y+ +  R        
Sbjct: 1204 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1253

Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
            E++     E    L+    WL + + KL     + G A      L  L+ L  H  +   
Sbjct: 1254 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1313

Query: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
             +  +  T  D     + +  +  LE+    W+         Q  L ++          L
Sbjct: 1314 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371

Query: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
             L+++    +D+ L         A +      + QS+  + EI L +MKK ++   A + 
Sbjct: 1372 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1431

Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
             + ++   AQ+ L +  +  R+  +      R Q   + +L+++K     +++    +  
Sbjct: 1432 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1489

Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
            + S  +   + +K+   V ++++ V        +KT                     G +
Sbjct: 1490 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1520

Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
             V+  +    + L + +        EL + V +    LEK L L+++   +   LT+W+A
Sbjct: 1521 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1580

Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
                 L      +       ++++  K+ Q+ +   +  +KS+ E GEAL  ++  ++  
Sbjct: 1581 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1640

Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
            ++DK+  L S++  + S  +E +  L    K  E ++  +  + KW++Q      A  LL
Sbjct: 1641 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1694

Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
            + S  +   Q+    K +  E+     ++++ + +   L+    DH +       ++L  
Sbjct: 1695 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1754

Query: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
               A     K   ++I         S  Q++ + LE E+Q+ V+ ++     + +   + 
Sbjct: 1755 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1809

Query: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
             D E + +  L R + ++Q    R   E+ R  + +   +    + ++    KD++    
Sbjct: 1810 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1857

Query: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
               Q+  +A  ++  W + K    +L   L D +++L ++     E           ++K
Sbjct: 1858 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1905

Query: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
            +  ++LQ K+  +N +  +   L++                  +E   +  +   LN   
Sbjct: 1906 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1965

Query: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +   R+   + +  +  L+         T   H    ++EV  E+     D L   D E 
Sbjct: 1966 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2022

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
                 E+LK +  +LQ+    I+ +  +K   ++     ++  ++E  S L+ +W ++  
Sbjct: 2023 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2082

Query: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
            + K    +   SV      +     F + +  AE+     Q P   E  K        Q+
Sbjct: 2083 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2142

Query: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
             +     +   L A  ++++ +S   DA  +   LG LN R Q + K LSD +  +    
Sbjct: 2143 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2202

Query: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
            +++ + ++ LN+ +   E+   + ++     + QQ + K+   E + LL +++  +    
Sbjct: 2203 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2255

Query: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
               Q  LK   NE  G       +  E  EQ+K E   KL++    +  V +    +  E
Sbjct: 2256 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2307

Query: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
            +E   K+L   +   ED ++  +    WL     Q +I   P           EI +  +
Sbjct: 2308 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2367

Query: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
              ++   L+K Q++ ++ P  + +   L  L    + +   L E     L  K   L   
Sbjct: 2368 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2422

Query: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
               I A        V + ++ ++   S +E+ +  + E+ A     ++  T+L   + LS
Sbjct: 2423 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2479

Query: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
            L D        + G  E ++E+  K++      +  +P ++  L+T    LK +T     
Sbjct: 2480 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2538

Query: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
                  R+  +++     QEH +   QQL   LK        KEE  +V  +     E  
Sbjct: 2539 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2598

Query: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
            K       ++Q      K++   L     ++D    LA +  R        ++ ++T   
Sbjct: 2599 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2658

Query: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
                 +I + V+E E+ + ++      F  ++ + L WL   +AE +  V  D      L
Sbjct: 2659 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2716

Query: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
             +  + ++++    +++Q  +     + H   E   K  + L  +D    L+  L  ++ 
Sbjct: 2717 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2776

Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
               ++++     ++ L     Q +R +   Q    WL+    EL + A  G D  + ++ 
Sbjct: 2777 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2836

Query: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
               H  F     T++    +  E   +  T  PL    G E L Q+   L  E R+Q ++
Sbjct: 2837 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2893

Query: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
            R    Q + +    ++      D+Q+  +E +E + + ++       KL +  ++K S  
Sbjct: 2894 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2953

Query: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
                      ++ L + KAL   +    E +  + + A QL   G   S   LS ++  +
Sbjct: 2954 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3012

Query: 5189 WQRWTRLRAVAQDQEKILEDA 5209
              RW  L+   +D+ + L +A
Sbjct: 3013 NTRWKLLQVAVEDRVRQLHEA 3033



 Score =  191 bits (486), Expect = 2e-47
 Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6656
            + ++L+ G  K+ G  K+    + E+Q+ ++     ++ L  + M     L R ++    
Sbjct: 388  VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 446

Query: 6657 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6715
            QK  + +  L        K   +  G +LE +          Q++L ++   V S    V
Sbjct: 447  QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 506

Query: 6716 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6761
             +V+E+        L +++ +     +++  +    + +L D          ++ L S  
Sbjct: 507  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566

Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
             S+ E  +N++      + N+M   L +L  +LK     + +S   ++ L+  +D L   
Sbjct: 567  LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 623

Query: 6822 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
              +SVT   E       R   N   +  K     S   ++   +  Q   ++ V T T R
Sbjct: 624  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683

Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6935
             ++    +Q  + L   P   +K  Q+ +D    +     I+E+ SWI+  E V+Q  E 
Sbjct: 684  EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 739

Query: 6936 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6994
             I    G     +  +K    + +   K   +   ++S   +  Q V E   +D    A 
Sbjct: 740  AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797

Query: 6995 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 7046
            +   +N  W     L++E++        +W EY+NN+       Q L+    T E  LK 
Sbjct: 798  E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 847

Query: 7047 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7104
            Q     +  ++++ LK C+D  + +   + ++E+++   +AL +  +    + +  ++  
Sbjct: 848  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 907

Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
                Q ++++     +L+ +  ++      ++     I +++ ++   LS  +L     E
Sbjct: 908  NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965

Query: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
             ++ ++  LQ LQ  L++Q+  L    +   ++ K+    ++    +  +E+  RW  L 
Sbjct: 966  IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025

Query: 7225 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
             ++ E  Q  +  +   ++ +++ +     + + +    E   A  + +I   +    ++
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1081

Query: 7285 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7341
             C  L+  + T++ SL  ++E G+++K + +   AS ++++   L+    H+C   Q + 
Sbjct: 1082 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1138

Query: 7342 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7401
             ++ +L+ G+    +  K L  +  W+ +AEE    +D  + +    +Q+ +EE+K    
Sbjct: 1139 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1197

Query: 7402 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7454
            +       +  L E     +    P+  + +K+ ++ L  ++  + ++   +   L+  +
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257

Query: 7455 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7512
               H+  ++LEK   W+   V+ + K    I G  + + E     +  +  M   +   +
Sbjct: 1258 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1313

Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7572
             I I  Q L + G +D+    N +L   +++W+ +   A +R+ +++  I+  Q   +  
Sbjct: 1314 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371

Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7631
              +++ L               I  Q A  + D+V   +     Q+  S + + E   + 
Sbjct: 1372 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1418

Query: 7632 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
            +   + G EAA Q  L++I   Q+K +  SM+    +K   F        E+ + +S   
Sbjct: 1419 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1469

Query: 7689 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
            L   K  L   ++     E + ++   C  L  ++     ++  +      +      ++
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529

Query: 7747 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7806
               L+ERV  L+  + EL  +++ R+QQ+ + L       ++   L EWL   + ++++ 
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589

Query: 7807 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
                +E M   L       K  Q+EI   + +   + ++GE L K     K + +E KL 
Sbjct: 1590 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1646

Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
             +N  W  +       +  L E    ++  D+N+  +  W+   ++ L           +
Sbjct: 1647 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1695

Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
            E ++K  +Q+E              VL   +  L+D        + DS +    NL    
Sbjct: 1696 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1737

Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 8039
             + C   +E ++                         SE    F + S  I T  A   L
Sbjct: 1738 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1772

Query: 8040 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8094
            K+ E F   + + L  LE      +N +     ++   D+  ++K+++    QR DNLQ+
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1828

Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8154
            R+T                                             + K +++K  QQ
Sbjct: 1829 RITD--------------------------------------------ERKREEIKIKQQ 1844

Query: 8155 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8214
             +   HN ++ + +Q  +         A  I  +  + +R   ++   ++   KKL  LP
Sbjct: 1845 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1896

Query: 8215 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8274
             P DE  + + + EL+      +L+   R A+ L   +  + +++   Q   S+R     
Sbjct: 1897 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1952

Query: 8275 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 8334
                    L +   + +  +    M+  +P E                 +S   S   ++
Sbjct: 1953 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1995

Query: 8335 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
            I  + +AL     +++Q  N         P+L             C+   + + + E  L
Sbjct: 1996 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2030

Query: 8395 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 8434
            K  ++SL    G ++ +HS +T   Q+A  ++R             WE +      ++ R
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2090

Query: 8435 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 8493
              ++++KW++F+ D+     WL + E+ L + Q  E          + K  LKELQ  + 
Sbjct: 2091 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2145

Query: 8494 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
             R+ ++ ++N    E  Q  SK ++  LQ++L  +N RW  VC  L + +  L++     
Sbjct: 2146 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2205

Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
              F    +  +L LE  D   +  +P++   + + L++  +Q+  +  EL   Q  +  L
Sbjct: 2206 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2262

Query: 8613 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 8659
             +    +LV+A    E  D LE K K        +   L     E+   IK+L    +KL
Sbjct: 2263 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2322

Query: 8660 LDVSSSQQDLSSWSS 8674
             D+      L  W S
Sbjct: 2323 EDLEEQLNHLLLWLS 2337



 Score =  187 bits (474), Expect = 5e-46
 Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)

Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
            E     ++  L   WE L+    EKQ  L+  L + Q +    L    TK E    K+ E
Sbjct: 409  ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 468

Query: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
             P        + Q+ +H+ L +++   Q  +N L   +   +V +    D A   AL+  
Sbjct: 469  EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 524

Query: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
            L VL +R + I      +  LL++ L   L+ QR  +EQ L           +WL   + 
Sbjct: 525  LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 572

Query: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
             ++   +   K+  +M + L     +  ++E+K  ++ +L    ++LL  L+ K+ T+  
Sbjct: 573  AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 632

Query: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
               L    R       +L+ S  ++ +A+   Q ++ Q T  E     V    T+   + 
Sbjct: 633  EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 688

Query: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
            +   +       Q++  +    E+ + L    + L S  +R E +L              
Sbjct: 689  KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 748

Query: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
                     I+   AE      DA      L +++  EG  +     A +Q+  +W    
Sbjct: 749  SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 808

Query: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
            Q  S +   L+   N++      Q+ EQ+  +  N L   +       PT  KS +    
Sbjct: 809  QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 866

Query: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
               + L GL    E +  QS   K +              + H +Q   D          
Sbjct: 867  DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 926

Query: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
                         +SA  TW+   E +L +    +   E  E  L   + L   ++E   
Sbjct: 927  IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 986

Query: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
             +        + +K   S+   +     + IE       GR   L S + + C +++E++
Sbjct: 987  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1039

Query: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
             ++   QN ++ L   +A+    + ++   + +  +  +Q++  +     ++     +  
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1099

Query: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
            +   G K++ E +P        EL +L   +D +   + +R+  L   L      ++ L 
Sbjct: 1100 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1159

Query: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
            ++ + +   +E+   ++     + +E+Q+ ++   + KE  Q  E+ + +LTE++   I 
Sbjct: 1160 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1218

Query: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
                    A++KE +    L      +  R + +   LE +   W  L    ++ ++ L 
Sbjct: 1219 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1275

Query: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
             VE  + +     G  EE  + L     L +H + + N+ +  L Q L DG         
Sbjct: 1276 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1325

Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
              ++  +N+  E + S   ++ +E  R + +L+   +   E+   +H +Q   + L F  
Sbjct: 1326 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1382

Query: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
            +Q          +  +PQE + ++  L +     +E+   +  K +     +Q+ +  KK
Sbjct: 1383 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1442

Query: 6872 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6914
            +   +++  L +  + +   L            ++PA++ K  + ++ +    H      
Sbjct: 1443 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1502

Query: 6915 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6956
            ++SEV S + ++      ++QK + +N K             N +G K      Q  K  
Sbjct: 1503 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1562

Query: 6957 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6986
            K+    ++             ++   +S ++               + +++E ++     
Sbjct: 1563 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1622

Query: 6987 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
                           +T   ++L  +N +W  +     E + LL    +    ++ NV  
Sbjct: 1623 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1682

Query: 7034 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7086
            +  W    +  L +  +           K  Q  ED++K  + E       V+       
Sbjct: 1683 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1731

Query: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7144
             L+ N+ +    +V   + EL   +A + H +  G+  I LK +    S  +   + + +
Sbjct: 1732 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1791

Query: 7145 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7198
                   L E  ++        G+++ +  + DNLQ    D  K+E        I  QLL
Sbjct: 1792 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1846

Query: 7199 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7258
            +  H        N LK++  +      EI+ Q          W +YK  +      +   
Sbjct: 1847 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1888

Query: 7259 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7318
            E +   L +    + I             ++ + L   K+ L  +    E L +     A
Sbjct: 1889 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1933

Query: 7319 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7358
            A A++  Q+ LS+    +E    +            ++ ++     D          T+ 
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1993

Query: 7359 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7416
              +  +   ++E E++L   D       DL   +E ++ +K  + + S     +      
Sbjct: 1994 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053

Query: 7417 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
              +     + +K  + L++    W  ++    +R  +    + + + F    + + ++L 
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113

Query: 7474 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7532
            + EQ L   +I  N++H   +    EL Q  +  RQ ++ ++   G+ +++Q    D   
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2172

Query: 7533 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
               KL  L+ +WQ V ++   R+  ++ Q      ++    +   WL E        + S
Sbjct: 2173 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2227

Query: 7593 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7647
            +P+     QQ +   ++V+   +    +QG      E G  +L+SA    E    L+ +L
Sbjct: 2228 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2287

Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7704
             +   +W   S  L E++ ++   +KD  + EK + D  E+L      LS     L  ++
Sbjct: 2288 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2347

Query: 7705 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7762
            +         +E E AV +   D+ +  +L      Y        +  ++E L  +W+  
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2405

Query: 7763 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7784
              L  +L  ++  +   L                     E A+                 
Sbjct: 2406 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2465

Query: 7785 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7838
             F+    EL +WL+ ++  +       GD+  I EMI K K   Q+     ++ + QL++
Sbjct: 2466 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2521

Query: 7839 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7887
            +    + L  K S++   + I  ++ ++ ++W  + + +  R ++L E        L A 
Sbjct: 2522 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2581

Query: 7888 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7947
            ++ ++ +   R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    
Sbjct: 2582 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2633

Query: 7948 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
            +L   LL D  A  T      +   T N++  WR+I     ER   +EET RL Q+F  D
Sbjct: 2634 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2689

Query: 8008 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
              +F  WL  +E TA               S GV     KE +K+++  Q ++       
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2744

Query: 8057 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
              +++  +++ R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    
Sbjct: 2745 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2804

Query: 8116 ARDSILVWLTEMDLQLT 8132
            +   +LVWL   D +L+
Sbjct: 2805 SLQELLVWLQLKDDELS 2821



 Score =  179 bits (453), Expect = 1e-43
 Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)

Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
            +L E+     +YQ +L+ + + + + E  L    E     E    Q   H+  M ++   
Sbjct: 325  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 384

Query: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
            Q  +  +   L  +L+    +    E+  +Q  + +L  R   +R+ +  K+  L   L 
Sbjct: 385  QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442

Query: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
            D      Q Q L+       EL+ WL  T+         P  P   D++ Q+   + +  
Sbjct: 443  DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 490

Query: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
            ++EQ+ V ++ L+    V +E+      A  +++ + L  +              L+  L
Sbjct: 491  DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 550

Query: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
            L+ QR L ++Q        EKE++   +  T      E L            SSLQ+   
Sbjct: 551  LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 597

Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
            L+ +L ++K  +  + S  +++L        +                  +K+ A  D  
Sbjct: 598  LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 639

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
               W++L Q+       L+    Q  + V  ++P+   + V      V T+++  V    
Sbjct: 640  ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 688

Query: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
                 A EE+       KRQ      + ++L   ++   +W+   E  L        +  
Sbjct: 689  ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 737

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
            E  +F +E    D+KE    +++ K          +  +QA  E   N  V  D++    
Sbjct: 738  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797

Query: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
             +L+   S   + C  + ERL        I+ F N L+ L   T+ A+N ++ +Q     
Sbjct: 798  EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 853

Query: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
                +  Q++  +   + L      I  LK +   L+ +      L        + + ++
Sbjct: 854  EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913

Query: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
               + +R   L    +     +Y+  +  +   ++  + K++       D +I+     E
Sbjct: 914  FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
            +Q L    +E   GL       + + +K  S   +K      E+  +    +S +++   
Sbjct: 974  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033

Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
            K   ++  + +  +H+   ++ ++     ++   P++G    + + L  ++   + L S 
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1089

Query: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
            +   QP L  V + G+++         S LE++L +L   W     ++      L+  L+
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1149

Query: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
                 Q + +++  W+  A++  E+  +      P EL+   + +    E +++ +A+  
Sbjct: 1150 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1207

Query: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
            L +   S  + + +   V    L+ EL  + + +  L T +    + L ++         
Sbjct: 1208 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1265

Query: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
             + +   W++ +E  + K  +NI    G + I E L   +      N  + + D  NQ  
Sbjct: 1266 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1314

Query: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
            ++I +Q +           E+L   N  W+ L      + +LLE  ++S  E E ++  +
Sbjct: 1315 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1374

Query: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
            +      +K+L     I D+       ++ Q ++  + + E  +E+++++          
Sbjct: 1375 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1432

Query: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
               + + Q K +DVS         L Q  AN +  + + K++L                 
Sbjct: 1433 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1471

Query: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
                 E +  L      +   E VQ Q+++  NL   L + +  ++       Q++++  
Sbjct: 1472 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1526

Query: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
                + L   +  + + +N L  ++ E+ Q  +  L+L ++ +   K+     +      
Sbjct: 1527 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1583

Query: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
             EL K +  + +    D EVA W +      K +   K  L  + E+GE LK  +     
Sbjct: 1584 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1637

Query: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
              +  D+LSL         +  ++  +L   +L+Y    ETF ++++ +  WI++A+ +L
Sbjct: 1638 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1694

Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
                    S+    Q++ + LK    + + + P +D   +    L  N  +  R      
Sbjct: 1695 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1748

Query: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
            +  LN  ++ IS +  T + S     L Q  + ++K    +E  +Q    L  E      
Sbjct: 1749 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1806

Query: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
               +    +E    E+  R   L   I D ++         R+E  +K  LL  +   + 
Sbjct: 1807 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1854

Query: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
                QRR        QW +Y+  A+ L K L ++       L S+P P        DE +
Sbjct: 1855 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1903

Query: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
             KE     Q+    L     +   LS D GA  A++    ++ ++W+    +   Q ++L
Sbjct: 1904 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1961

Query: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
             F          ++   E     I+       T    +SQ+L +  + L+A  +  K+ E
Sbjct: 1962 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2021

Query: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
            +      ++ +  D L Q S   D +     +A  SA  +    L E +  L  QWE++ 
Sbjct: 2022 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2081

Query: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
                 R+ +    + +W  F    K   +WLT+ E  + +     I E  E  K     K
Sbjct: 2082 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2138

Query: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
            + Q+ I   Q     L   GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L
Sbjct: 2139 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2198

Query: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
            +E    + +  ++++    WL   ++  + P+  +    ++++ KL + + L  ++    
Sbjct: 2199 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2256

Query: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
             G+   LN     VL+    A  +  E D ++   +  + +W  +     E++ +IE   
Sbjct: 2257 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312

Query: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
             +  +L +K  D   +      WL              +   F      I   AK+    
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372

Query: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
                       E    +  +R++ +  ++ + +N+  + L R  + D A  L  +     
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2431

Query: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
            Q    + + V    T+I +      L   +    +F  A   +  WL+ +D  ++   + 
Sbjct: 2432 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491

Query: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
                 D+   I + KA  Q++     ++E++I   + L  K+   +A  II + ++ ++ 
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551

Query: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
               EV   ++   ++L  +     +   +  E E     A + L        ++ + Q  
Sbjct: 2552 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2611

Query: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
               +  LA+ LR                 +W  + D++ DL   + R   ++D       
Sbjct: 2612 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2654

Query: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
             ++    +      +S   +ALE   R L +  LD  +F     + + T N+++  T   
Sbjct: 2655 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2714

Query: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
              L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   +
Sbjct: 2715 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2774

Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
              +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   
Sbjct: 2775 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2832

Query: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
            ++ Q    +  ++ +  ++ +I+S       F      E                     
Sbjct: 2833 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2892

Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
            +R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K   
Sbjct: 2893 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2952

Query: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
             P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2953 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2994



 Score =  179 bits (453), Expect = 1e-43
 Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)

Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
            RYQ+   +++ WL SA+D L    Q    +  ++E+V+D  +    +  ++ A      +
Sbjct: 335  RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 390

Query: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
            +L  G++L+   +L + +   ++ +++ ++S+W  L       Q  LH++ MD       
Sbjct: 391  ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 448

Query: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
            + E+  W++  E   +K E+        + +   +Q++K  + D+  +Q+ V+ +   V+
Sbjct: 449  LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 507

Query: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
             +   D  S         EQL  +   W  +     ++  LL+ +L  W           
Sbjct: 508  VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 564

Query: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7090
             W   +E  + + H  G  DQ  + ++L+    L+  ++ K++ + K+   +Q+ L+ ++
Sbjct: 565  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 624

Query: 7091 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7121
            NK                              +S  V +T   L QT     +  +  + 
Sbjct: 625  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 684

Query: 7122 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
            +IL+K   ++          ++  D     +++  + E    ++R   +  S E A+  +
Sbjct: 685  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 744

Query: 7170 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7218
              N  +L++ +   ER   +KF           ++  Q++ E      +++    +++N 
Sbjct: 745  EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 802

Query: 7219 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7275
            RW    + ++E+L         W  Y++      + +QQ E  T      LK        
Sbjct: 803  RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 854

Query: 7276 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7335
               + + ++ C D +  L  ++  +  L      LK++        + +D ++ + H   
Sbjct: 855  PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 912

Query: 7336 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7393
            +   +  ++  LQ     L    + +++ A+  W+ ++E  L     S  +D   +++R+
Sbjct: 913  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 971

Query: 7394 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7447
             EL+            L  L+    E+  + P  ++ K     + +   W  +SSQ  E 
Sbjct: 972  GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1031

Query: 7448 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7505
              KL+  + + +      +T  +++ + +  L  E    G+ + L +Q +   L  +++ 
Sbjct: 1032 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1091

Query: 7506 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7565
            + Q  L+S+   GQ++  + + +       +L  L+ QW  + ++   R+  +   + + 
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151

Query: 7566 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7623
               ++   ++ +W+   E  YL        P  LQ+A    +E++  ++   +++    L
Sbjct: 1152 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1208

Query: 7624 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7683
              E+   ++  A   A+ AL+ EL  +   ++    RL  + K L  +   W +    + 
Sbjct: 1209 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1268

Query: 7684 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7741
             + + L    FK K ++++P   EE+         LEN +    D+  Q+ +L  TL+  
Sbjct: 1269 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1325

Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
               D++  +NE +E    +W EL H+ ++RRQ++ E+  + A  +EK+  L         
Sbjct: 1326 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1373

Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7856
                     I+E +  + K     IA    +K+   QM +   K      SHE    E++
Sbjct: 1374 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1420

Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7910
             K  +  +  Q +L  I    KKL++  +  +   K       +   +  L  ++  L  
Sbjct: 1421 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1479

Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
             +   S   E +Q +LN    L + + +  + V  V+     ++              + 
Sbjct: 1480 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1534

Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8030
            +    L   +  + A   ER+ ++E+  +L +K   + +   +WL +++      S+   
Sbjct: 1535 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1594

Query: 8031 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8085
            + +    E+   +A Q+++ +    L+ I +    L      +E   +   SL       
Sbjct: 1595 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1648

Query: 8086 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8145
            N  W  +  R    L  L  +    E F+   D I  W+ + D  L   E       +  
Sbjct: 1649 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1708

Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
            +K+LKA   +I     K++    Q   L+         ++E ++ EL      +  R++ 
Sbjct: 1709 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1765

Query: 8206 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 8260
                +    L     D    L   E E++    L +  ++ D + D+  + +       +
Sbjct: 1766 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1825

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 8319
            L Q +  ER   +       +  +    ++  +DL S    +AL    +  Q     Y R
Sbjct: 1826 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1876

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             A  L      +E ++  L +  D+ +  I++ +  ++ K      +    +G  +  G 
Sbjct: 1877 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1933

Query: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439
              +   +  +L  + +E E     F  L+  +  T  V +   ++  + +  E+    + 
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1991

Query: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499
                 + +++  +   L + E+ L        + D + +  Q + LK ++ ++      I
Sbjct: 1992 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2044

Query: 8500 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 8556
              I+       Q+ +   R  LQ+ LSQ++ +W++V  + ++ +G    ++ + + FH  
Sbjct: 2045 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2104

Query: 8557 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 8615
             ++ +  L   E   R+      I  N +    + + K+L      + + Q  V +L   
Sbjct: 2105 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2157

Query: 8616 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 8674
              +++  +  TD    +EK+  +  R + + K++S   K LE+  ++ S  Q+DL+ +  
Sbjct: 2158 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2217

Query: 8675 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 8702
              +E D   S+    G+    ++K  + K
Sbjct: 2218 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2246



 Score =  179 bits (453), Expect = 1e-43
 Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)

Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
            H+ ++++L   Q  +G + Q    ++  G   +  EE  + +++  +  R  CL +    
Sbjct: 374  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 432

Query: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
            K +N   V  +L+++++ E     +  W+ +T+E      +E +    +L+ L  +   H
Sbjct: 433  KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 485

Query: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
            +   E + +EQ +   L    ++  E S   A  AL+ +++   D+  +  +  E     
Sbjct: 486  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545

Query: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
             Q++  + Q+L ++       L  K D V +  T       E+     KL  L A ++K 
Sbjct: 546  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 604

Query: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
                        + +GKL  L Q  +   +N+ S   +  + L+ +    + +++ +EK 
Sbjct: 605  ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 652

Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
                       S +Q+ +     Q  L +           T  ++ +T+V   E++  + 
Sbjct: 653  -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 690

Query: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
            A+     EEL      + + +   ++  K+ + ++ +L + + +++A L SPE      +
Sbjct: 691  AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 745

Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
               S  +  ++ +E  + K +  +  Q A R  + +V  +      A  +++ + +L   
Sbjct: 746  GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803

Query: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
             I+ C ++   +  ++Y+     +  +++ L+Q+   A   ++ +P   S    +++Q+ 
Sbjct: 804  WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 863

Query: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
              ++   ++ G Q QI  L  K + + +K K               +G   LD + +   
Sbjct: 864  ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 907

Query: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
            +    V      R   L      L P+  +       + +       S   ++ TD  + 
Sbjct: 908  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967

Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
             Q +   QAL +   +  +   + ST+  +   +   E S    ++  +++  W+ L + 
Sbjct: 968  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1027

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
            + E  + L E + + +K Q+ +Q++   M  +++ L E  P  G S   + Q+ + + L+
Sbjct: 1028 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1087

Query: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
             +I  +Q  +N +     +++ +E   A+P     L++ L  L  +   +  +   +++ 
Sbjct: 1088 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143

Query: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
            L+  L   +  Q+    +  +  +A+E      +   T   L  A+   K   +   Q  
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203

Query: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6184
                +L E    V+A +   V  E L  E +  T +  + L  +L     +L E+    H
Sbjct: 1204 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1261

Query: 6185 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6243
            +    ++   +   E +  L  T++ PG  E                     E+ + L  
Sbjct: 1262 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1300

Query: 6244 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6303
             ++L+R       +I I    A+T  D G   +++++EL          +    +W  LH
Sbjct: 1301 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1347

Query: 6304 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6353
            +E   +QKLL+  ++  QE        Q   +  ++ L+     K D     Q+   + S
Sbjct: 1348 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1407

Query: 6354 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6405
             L     + EE+   + G +        I + QK    VS          + E+RL  + 
Sbjct: 1408 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1467

Query: 6406 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6448
             +L E        ET    QE+          L K + E+  E++       Q    +  
Sbjct: 1468 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1527

Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6508
            +N   +++ +  L    + L + V +R  Q+++ L+     + ++ VL   LA     + 
Sbjct: 1528 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1587

Query: 6509 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
            ++ A   E   +     +   +   KE +   + LK      +V +     L K + + +
Sbjct: 1588 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1642

Query: 6569 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6611
            + + ++ S      S   + L L  +Y++ ++               AD L    EK   
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702

Query: 6612 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6669
             QK  ++   K E+  +  K         + M       RK++   +       +EL  +
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1755

Query: 6670 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6724
             +A+  R    K  + L+        L++   ++ + LE +E+ I   V L EE  N+D 
Sbjct: 1756 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1808

Query: 6725 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6784
              D     + L    +  Q +   + D+ KR  I I    L+++ N L +       K  
Sbjct: 1809 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1865

Query: 6785 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6839
            +  H+       W +Y+ ++ DL+  L   + +L    +     +   + +EL+  ++ L
Sbjct: 1866 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1918

Query: 6840 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
            NA    ++ +    +  +              + S   Q  RL      T+R E   + +
Sbjct: 1919 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1978

Query: 6887 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
            +   L ++ +P+  + E  H  Q        A+ EV   ++  +   +  ED  K     
Sbjct: 1979 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2030

Query: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
            K I + LQ+  G +IDI   + T      + LQ S+  VE     +    E L  ++  W
Sbjct: 2031 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2077

Query: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 7061
            + +  +  ++    +  +E W  +  +++    W    E+ L+  Q     + A  +  L
Sbjct: 2078 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2137

Query: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
            K   +L+D I  ++  V  +   G  +IQ   +  +SI+   L  L   W  +   +   
Sbjct: 2138 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2194

Query: 7122 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7181
            K  L+   +  S  +   ++   +L EA  +++   L  G  + ++ +++ ++ L ++L 
Sbjct: 2195 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2253

Query: 7182 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7235
             ++  L++       +L      P   + L N LK+ N++W      L E+  E     K
Sbjct: 2254 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2313

Query: 7236 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7287
             L QL ++ +D  +Q        S ++ Q +  N+  +     D+ + E+A   +  D  
Sbjct: 2314 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2372

Query: 7288 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7323
            ++L KG    K+          L +L  + K      Q++ A             AS  Q
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2432

Query: 7324 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7381
            +  L ++Q +   E A+ K +  +SL   V     F ++   L  W+   +++++ Q   
Sbjct: 2433 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491

Query: 7382 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7434
               DL  I E + + K  M       P L+ L      L    +++E +     R++ + 
Sbjct: 2492 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2550

Query: 7435 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7494
              W  +      R  +L   L     +LE  E   + L Q   KL     G Y     Q+
Sbjct: 2551 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2610

Query: 7495 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
            +  E  Q     RQ   +  + +    +LL     DD  + ++    ++  W+ + +R  
Sbjct: 2611 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2670

Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7611
            +R   ++   R  Q++    EK   WL E      +    +    ++ R L D    KE 
Sbjct: 2671 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2726

Query: 7612 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7662
             K +   QG        Y    E  +++L S +   +A  LQ  L  +  KW     +  
Sbjct: 2727 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2786

Query: 7663 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7714
              +  L      W++    + + L  L+    +LS+  P            ++H    R 
Sbjct: 2787 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2846

Query: 7715 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7760
             + +  V   T +  ++ L +  L                  A +++ +L ++ E +  +
Sbjct: 2847 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2906

Query: 7761 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7817
            WE+L    +  +++I E L       E   EL   L Q E         GD+LI+ + + 
Sbjct: 2907 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2966

Query: 7818 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
            L+  K  + EIA  +EN   +  +  +L     +     +   L  +N RW+ L   +  
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3025

Query: 7876 RVKKLKE 7882
            RV++L E
Sbjct: 3026 RVRQLHE 3032



 Score =  176 bits (446), Expect = 9e-43
 Identities = 468/2732 (17%), Positives = 1059/2732 (38%), Gaps = 408/2732 (14%)

Query: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
            S E+ +    E+    E + D  +  E   + L  HQ +   I         Q+     G
Sbjct: 349  SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 400

Query: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
             G L +       E++  L S  + L   S E+Q    R+ + L+  +  E N + + + 
Sbjct: 401  TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 459

Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
              +T    E  L    LE L  +++Q K   +  E   V+  +L      V E+S    G
Sbjct: 460  EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 514

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
                  L++Q K + ++   +    E+    ++ +  KW          S W++EKE  +
Sbjct: 515  DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 574

Query: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
            N + T+      +M  S  K+ + + +        LE++ QS  +  +  +      K  
Sbjct: 575  NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 626

Query: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
             + +  E  L   A+C +  +       QK E++  +I Q+V+  +  L          T
Sbjct: 627  SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 669

Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
            +T             +E++++  T      R+ +      +E      Q        K+R
Sbjct: 670  QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 704

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
            Q  +++ +   +RL+ +++   +W+ R EA   SPE  I           + + A++ E 
Sbjct: 705  QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 761

Query: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
              +A  + KL     S  ++  +      +   +K   EQL+ RW +  Q++++R+N+L+
Sbjct: 762  --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 819

Query: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
               +++A   + QQ +++  +   W+K+   +  T SE + +  Q+ +   KD    +  
Sbjct: 820  YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 874

Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
             + +++ L+     L   G+      L          F++    V+ R+  L  + + L 
Sbjct: 875  LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 932

Query: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
              +   ++S I   ++Q  T  +   ++  + +++E+ L +      +L+     L  + 
Sbjct: 933  PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 992

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
            +  +   K   SE     ++  +++ G  +++ + L     + +      +  Q+  + L
Sbjct: 993  TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1052

Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
             K + +++    +E       + L+++L+    L  ++ + +  L  + +  ++I  + +
Sbjct: 1053 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1112

Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
              FA  ++ E+  L   WD   + ++  +    G ++     Q   S + + +  A    
Sbjct: 1113 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1172

Query: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
            + R    K  ++L+ A  + + AK +   K+  +   T     ++++   +       +K
Sbjct: 1173 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1229

Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
             ++E+    +  +  +L      L    + W ++LS  ++   W N    ++   +   +
Sbjct: 1230 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1285

Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
            N     E + E    ++N     E+  +++  L +   +     +L   E +        
Sbjct: 1286 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1345

Query: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
                 V +  L + + QS Q  EK ++ I    T +++ L     ++   A      + +
Sbjct: 1346 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1400

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            E Q  QS+++S + +L  +  K H+   E+  R ++ +    + +  +  K +   + + 
Sbjct: 1401 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1457

Query: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
              +F + +QE +      K        ++ + +V++++L+   N+  S+S+ +S+++ V 
Sbjct: 1458 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1515

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            + G+ +      +    + E++T     +     +  + KQ L+ C         +   L
Sbjct: 1516 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1575

Query: 2528 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2569
              W+     E+ +R   E +          G++ Q   EK+      + +V   L  +L 
Sbjct: 1576 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1635

Query: 2570 ARESL--DKLS------------------------------------------QRGQLLS 2585
             +E+L  DKLS                                          Q   LL 
Sbjct: 1636 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1695

Query: 2586 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2639
            E      Q+     + L +  N +R     T+++  +      +H  + +E  +  +   
Sbjct: 1696 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1755

Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2685
              AI  R+   ++++  K+ LE+  S IQ  LL   E E++  + +              
Sbjct: 1756 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1813

Query: 2686 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2737
            G  ++ L+  +   QR+   +     ++   ++ +  +A   L S        +  QW  
Sbjct: 1814 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1873

Query: 2738 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2791
            Y  + + L + ++ +++K+    +P+   K K +        + L ++  +AE  +    
Sbjct: 1874 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1933

Query: 2792 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
             +  +  ++         +    +  +  F  I TV +E M  + E +   + Y+ + + 
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 1992

Query: 2852 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2905
             T+  H ++     E+L    D+ + D     K+   +K + DS +  + R+  + S   
Sbjct: 1993 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2052

Query: 2906 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
               Q+ T      +   +  L   W++               V++M    Q   G+  + 
Sbjct: 2053 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2094

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3019
             +   +F   +K + Q LT  E      +I E W         +E+ D + + +     L
Sbjct: 2095 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2154

Query: 3020 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3074
             +   E+ + S   D S    K+  L   +  +C Q S   K  + ++ IL + F++   
Sbjct: 2155 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2213

Query: 3075 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3132
            +F  WL  A    +   + P    ++   L++++  + E    Q  L  +   G   L+S
Sbjct: 2214 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2272

Query: 3133 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3185
              ++ E+   ++ K+      W      L +K+  +E        L+ +++D E     +
Sbjct: 2273 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2332

Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
              WLS     +      +Y+ P  +     +Q     +   +P +  +  K Q L++ + 
Sbjct: 2333 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2386

Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3284
            A++  + ++  LSS++ A++ L +E  ++       L  I A   Q              
Sbjct: 2387 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2446

Query: 3285 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
                                F+    EL DW++    ++ S      D   ++   +K +
Sbjct: 2447 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2506

Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3383
            A +   +++  Q++ ++T  +++   TS +   T I  +++ +++ W  +       + Q
Sbjct: 2507 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2566

Query: 3384 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3426
            L   L   ++W   ++   Q  G        W      +D+++  + E+++   +LR   
Sbjct: 2567 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2626

Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
            T +  A  L  ++L   S  +T +V       H +T    +++   +R+I +R  E    
Sbjct: 2627 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2675

Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3523
             E+  RL Q++  DL+ F  WL + +                       E + Q+  L+G
Sbjct: 2676 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2735

Query: 3524 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3583
            +   H     +L E        Q +L S+  + + V+         R L+++   W   +
Sbjct: 2736 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2782

Query: 3584 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS---------PRTRRQS--NRA 3632
             +    R+      ++ + +    Q++  WL+  ++++S         P  ++Q+  +RA
Sbjct: 2783 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA 2842

Query: 3633 TK-EIQLHQ--MKKWHEEVTAYRDE-----VEEVGARAQEILDE---SHVNSRMGCQATQ 3681
             K E++  +  +    E V  +  E     +E++    +E+  E    +V   +  QA +
Sbjct: 2843 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE 2902

Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
            + + ++ L L   +  + ++E ++ L+E + +
Sbjct: 2903 VNTEWEKLNLHSADWQRKIDETLERLQELQEA 2934



 Score =  167 bits (423), Expect = 4e-40
 Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)

Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
            E+  +L  A+  LQ      +++E  + ++     + ++  L + Q  V  I++      
Sbjct: 342  EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 399

Query: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
               KL++ EE+   +++N LN +W       + +QSN   +  +   Q+ ++ +D +   
Sbjct: 400  GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 459

Query: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
            E          +   + + E     LE LK+    +Q+ K   EDL+   Q+ +   +L 
Sbjct: 460  E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 503

Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
               +V +++S  +     LE              E+L V+  R+  +  W E++      
Sbjct: 504  HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 544

Query: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
                         LL D L     L  +Q L  + + + +  +  +     +   + LS 
Sbjct: 545  -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 591

Query: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
             Q      +DL  ++++ + K  S K Q L++  +  S  Q+ E  +   ++     D+ 
Sbjct: 592  LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 646

Query: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
            V K  K+      ++ T Q  +T       E +  VT +E+  V    +EL         
Sbjct: 647  VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 697

Query: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
                + +++  +   RK    D  +   W+ +++ ++  PE  +  +         K   
Sbjct: 698  PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 757

Query: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
            I  +  E    L    R+ Q ++  +     N       SE+LN+   +F  +++   + 
Sbjct: 758  IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 817

Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
                   I    +   L ++TT + + L+ Q    S+ PT  A++  L +   C+  ++ 
Sbjct: 818  LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 871

Query: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
            ++GL   ++ L  +    +  GQ P   D      T + +      +  E+ +  + DT 
Sbjct: 872  LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 931

Query: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
               +  E M       QQ E +L      Q  V +  +  E++L    +L  SLQ+    
Sbjct: 932  PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 987

Query: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
            L  ++  +++++         K + + +  +G  K L+S + E   + E +M +    Q 
Sbjct: 988  LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1047

Query: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
             +     W+  V   L        + + +++++++ ++   ++Q+    +N+++   ++ 
Sbjct: 1048 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1107

Query: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
              +A+   ++ LE  L EL+     + + +  R+  L     +     +     ++W+  
Sbjct: 1108 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1167

Query: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
            A+E  +      + ++ +E  K+  E    +++      ++  L  +++ +I    P  +
Sbjct: 1168 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1225

Query: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
            E L++++ +L    Q +      +   L+   A WH+     E+  + +N+ E     F 
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1280

Query: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
            L  T +     E++SE      V++S    +   E+  +Q+       T        ++ 
Sbjct: 1281 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1334

Query: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
             + T   RW  L   A  ++K+LE ++         +    E +  +  +L    A+K  
Sbjct: 1335 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1394

Query: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
             A++              ++ Q     L    +S L++      G+E    Q + +  D 
Sbjct: 1395 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1438

Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5355
                 + V    +L ++        E ++   K  + E K +L  P +E        + +
Sbjct: 1439 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1492

Query: 5356 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5415
            QL     L    +  +  +E + +  ++      T  P EL  ++  + L     +++  
Sbjct: 1493 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1549

Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5471
            K+ E +Q      +LSR+++K       +LT+  A TD  +  ++  + +   LD     
Sbjct: 1550 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1605

Query: 5472 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5521
                 K +E      K + + G+     LGK       KL+ L+   I    +AE  L+ 
Sbjct: 1606 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1665

Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
            L +   H+E +++ ++ I KWI +A  L   +       Q +E  +  + L  E  +I  
Sbjct: 1666 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1721

Query: 5582 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
            ++++  ++   L +    +C + +  Q++EL      +   IK    ++    K++++F 
Sbjct: 1722 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1779

Query: 5639 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5689
            ++++KL   LE   Q    L   +  +   ++     + LL   ++L+ ++      + +
Sbjct: 1780 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1839

Query: 5690 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5749
            ++ Q  L+   + +  L       + +++A  + H   Q        +   +  E+++  
Sbjct: 1840 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1894

Query: 5750 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5802
            L     ++ I+   RE++ K    + ++  QA+    +  A  ++  Q Q++      + 
Sbjct: 1895 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1953

Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5862
            K    +  +   + TV E E +   TED+  E+   PS + + +        T +S    
Sbjct: 1954 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2004

Query: 5863 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5922
            E         +++P  C              ++I      S+ R+      IH   +A+ 
Sbjct: 2005 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2055

Query: 5923 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5982
            +   P         L  L   WE +  +  ++Q     ++E+ +++   ++  +  +   
Sbjct: 2056 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2115

Query: 5983 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 6036
            E  L ++  P      +  EH      +  LQD I + Q      ++  EE++ +S + D
Sbjct: 2116 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2169

Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
             +    LQ  L  L  R   +  + S +++ LEE          Q+  L  ++ + +E  
Sbjct: 2170 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2216

Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
             WL          L P KE   ++ +L   + ++ E+  +   L +L+     +L+    
Sbjct: 2217 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2275

Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6214
             + +E ++L  KL++     +++ RAL +KQ  ++   ++  + E  ++    Q   +  
Sbjct: 2276 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2334

Query: 6215 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
            WL+  R     + Q  Q      +E E  +  ++  +  + S+G+ +             
Sbjct: 2335 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2382

Query: 6272 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6331
             EKP               A   ++ K E L  E+    +LLQ +  ++ +         
Sbjct: 2383 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2418

Query: 6332 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
            L  G+    G  PTQ  + VT  +     A  ++   S      S+ LE       +   
Sbjct: 2419 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2471

Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
            T L D    L           +  + +Q ++  D+++++E + K K              
Sbjct: 2472 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2511

Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6511
                                + QR  Q++E +    N +N      TS  + + II    
Sbjct: 2512 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2542

Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6571
                     ++IE IQ   D ++E              LQ  +  + E+ K         
Sbjct: 2543 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2572

Query: 6572 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6629
                       Q L  K + E+ L      LE+ +E   G   +    K+  E +QL   
Sbjct: 2573 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2621

Query: 6630 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6689
             +++   ++    L   L R   +   +K       + A   ++ KR  +R   LE   E
Sbjct: 2622 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2678

Query: 6690 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6740
            T   L +   +L + L  +  +  +  ++++   ++RL+       + +  +Q L+  + 
Sbjct: 2679 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2738

Query: 6741 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
             +    + + ++ +++L S+  SD    L+ +L+ +   W     K       LE     
Sbjct: 2739 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2798

Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
            W R      +L+ WLQ   D L     +   +  +   V+   +    F +E+  +  + 
Sbjct: 2799 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2854

Query: 6857 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6895
             S L T    L  + ++                     T  LR +   ++++W  L  + 
Sbjct: 2855 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2914

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               Q K+ +  +++L      ++ +  + L +  + K        +   ++ ++L+K K 
Sbjct: 2915 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2972

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
             + +I   +  V  VN    Q+++  ++    + +   +    +N  W++LQ  V ++++
Sbjct: 2973 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3028

Query: 7016 LL 7017
             L
Sbjct: 3029 QL 3030



 Score =  162 bits (409), Expect = 2e-38
 Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)

Query: 600  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 652
            E +S  S L E   N DRY   +  + +WL  AE  L       N  E  K  F  +  +
Sbjct: 318  EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 377

Query: 653  WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 701
             +         GN L             E    ++++Q+ LLN RW   R   ME +   
Sbjct: 378  MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 437

Query: 702  QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 754
                MD   ++  +    L+       K   EPL     ++K  +Q       DLE  + 
Sbjct: 438  HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 497

Query: 755  RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 797
            RV  +     ++ +++      + +E+ K   + +A + +  E              +LT
Sbjct: 498  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557

Query: 798  KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
            + +  +S  L E +  +  +     K       SL K+  +   LE++ QS        Q
Sbjct: 558  EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 617

Query: 857  ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 899
            +LL+  +N   T                 +  +EK +  + + VT +       QT +  
Sbjct: 618  DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 675

Query: 900  QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
             +  +    Q +VK   +         K+ +  +S + K+ +    EL   +  ++  L+
Sbjct: 676  TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 735

Query: 952  EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 995
                PE  + R    FS L ++V NA           L+        L EQ         
Sbjct: 736  S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 791

Query: 996  GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1052
             +++A  +L+ +W +   L  E    L +    +     L  +E+  T  +   K+ P  
Sbjct: 792  SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 851

Query: 1053 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1111
             SE   IK       D+        RL  ++    +L ++       G   + L     A
Sbjct: 852  PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 905

Query: 1112 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
              + ++++  D    +              Y    S   +W+  +ET+L   +    D  
Sbjct: 906  FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965

Query: 1159 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1218
               +    ++ +++ + ++   L +L + +K +++ +    ++K   E  ++   +K L 
Sbjct: 966  IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025

Query: 1219 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1271
            + L E    +E+ ++       + + +K  + E+      ++E+   + D+E L    + 
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1082

Query: 1272 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1331
             +LL+   Q  +       +  Q+I    + E     R   EL++L +  D + +    +
Sbjct: 1083 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1140

Query: 1332 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1391
            +  ++  L K    + +   +  ++ Q   + E +L          EL++  E  KR + 
Sbjct: 1141 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1197

Query: 1392 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
             A Q E  VK  +E          P  ++ L+++ +++    + L   L    KT+E V 
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257

Query: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1505
              W    S  E  + W+ E E +L   E      +    +I   +  +E+ +        
Sbjct: 1258 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1313

Query: 1506 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
            + +  AQ +T G      I  +L        EL E A   +  +   +   Q+ E++L  
Sbjct: 1314 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373

Query: 1564 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1606
            IQ+S++  + +LA  I              KI S  T    + + +++H    +A + + 
Sbjct: 1374 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1433

Query: 1607 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1663
            S I       + V  +    Q+ A  +Q+ ++   IL   K    ALE      + ++ +
Sbjct: 1434 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1493

Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
            L+  +   +      S  EM I   R       Q++Q  Q E   +              
Sbjct: 1494 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1534

Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
                  + V  +KLH  +L  +  +  Q + K +   + +  E     E       W+  
Sbjct: 1535 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1581

Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
               EL   S +  M   +         A  ++ + E++  + HL  +  +G A  L  + 
Sbjct: 1582 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1634

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1901
            GK E    L E+   ++    +A+ S   E+L         +    Q V+  T  + + +
Sbjct: 1635 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1691

Query: 1902 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1961
            + L E +     Q    L+     L+ I  K        + +Q  +  A     C     
Sbjct: 1692 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1741

Query: 1962 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2019
             + L+  + SE +   A +    +  K  + LK +E     +D ++L EP    +QQ + 
Sbjct: 1742 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1798

Query: 2020 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2073
            +    FN  +D    +E  +  L  +   + Q+  D     E+  +   L+   +  K L
Sbjct: 1799 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1856

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
              + + +   +     +Y+     + K L++    + +    +D+  +K    + +  K 
Sbjct: 1857 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1916

Query: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2177
            ++N  ++  +  +  G  +  E  +I  S                +F+ + T  E T+  
Sbjct: 1917 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1974

Query: 2178 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2236
             + ++E +   +  +    L+    V     E+E   N   P +     + ++  + EE 
Sbjct: 1975 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2029

Query: 2237 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2296
            LK  +  ++  + R++ +HSK    K       TP +   ++  L Q     +++ ++ K
Sbjct: 2030 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2085

Query: 2297 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2350
                 F     +  +F  DI     W T+ E+ L      E  E  K    +K++Q  + 
Sbjct: 2086 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2145

Query: 2351 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2408
             +Q+ + +       + ++    +   L   +  L ++  E   QL   K +   Q+++ 
Sbjct: 2146 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2205

Query: 2409 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2468
              F   + EF  W   A   A    +  G  + L+ KL  ++ +++ +   Q  L  + +
Sbjct: 2206 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2264

Query: 2469 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
             G  +   A +S +    ++ ++ + N        Q +K  +AL +   E+ +       
Sbjct: 2265 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2310

Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
                          ++LG+ ++ + + + +++ + ++L  +    E  ++ +Q G    +
Sbjct: 2311 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2358

Query: 2587 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
            E   A Q  +    ++L+  Q+L +    T+   R  +    E +A+   LQ +    +A
Sbjct: 2359 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2414

Query: 2643 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2700
             Q  LA   +T+G+  T  + ++ +   ++ K     KL M  ++     AL   N+   
Sbjct: 2415 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2472

Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
             +           W  ++   + +Q  +   +   N+ + ++    Q +E          
Sbjct: 2473 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2513

Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
            Q +P L+E      +L++  S  E  T    R+                     E ++ Q
Sbjct: 2514 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2552

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            ++++    + + +++ E++KD   +L+A  E    L  A+ +L  W +      A QKK+
Sbjct: 2553 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2612

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
            ++ K+L        + +     LA ++ ++ +A     +H   + + A W+     V + 
Sbjct: 2613 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2672

Query: 2941 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 2997
            ++ LE    L+ Q  L  ++F   +A L +A E  + +L+   ++  LLE     +E+++
Sbjct: 2673 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2728

Query: 2998 CWHKGQEILDA 3008
             W   Q  ++A
Sbjct: 2729 QWQDLQGEIEA 2739



 Score =  159 bits (402), Expect = 1e-37
 Identities = 533/2914 (18%), Positives = 1109/2914 (38%), Gaps = 456/2914 (15%)

Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
            + ++   R++ A  +   WL++A+ T     +I  ++  V       + ++ +    Q +
Sbjct: 328  ESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGR 387

Query: 3121 LNMMLSKGELL--STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
            +  +L  G  L  +  L++++   +Q ++      W+       +K+S L  + + +++ 
Sbjct: 388  VGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQ 447

Query: 3179 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3236
            ++  + + DWL+KTE+   +        DL   +R+ Q+ + + E++   + ++N L   
Sbjct: 448  KL--KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 505

Query: 3237 AQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEK-------VSRLDRIVAEHNQFSL 3287
               + E  G  A+ +   ++  L  ++  +   T+++       + +  R+  E   FS 
Sbjct: 506  VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 565

Query: 3288 GIKELQDWMT--------DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE--KEIQM 3337
             + E +D +         D   ML S       K+ L+ +   +  L S+KQ+    ++ 
Sbjct: 566  WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 625

Query: 3338 KMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA--GIRCKSQLEGALSKWTSYQ 3395
            K +  + E+ L N +      +Q+  +S   +  ++ +    +   + +E   +  T  Q
Sbjct: 626  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 685

Query: 3396 DGVRQFSGWMDSMEANLNESERQHAELRDKT----TMLGKAKLLNEEVL----------- 3440
              V+     +              +E+R +     T L      +E VL           
Sbjct: 686  ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 745

Query: 3441 -SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQER-------AKEAVTKSEKLVR 3492
             ++S L E +        E +    +LQD     +A+ E+       A      SE+L  
Sbjct: 746  GNFSDLKEKVNAIEREKAEKF---RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS 802

Query: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
               E+ + L     WL  +   +  Y+ L+       TT  +  ++Q         + S 
Sbjct: 803  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQ-QLEQMTTTAENWLKIQPTTPSEPTAIKSQ 861

Query: 3553 LHTREDVIP--SGI-PQAEDRALESL-----------------------RQDWQAYQHRL 3586
            L   +D +   SG+ PQ E   ++S+                       +Q +   Q R 
Sbjct: 862  LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQARE 921

Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
             E +T F+ +   +R  E     +  W++ +E K+S      ++    E +L +++    
Sbjct: 922  KELQTIFDTLP-PMRYQET-MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 979

Query: 3647 EVTAYRDEVEEVGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3704
             +   +  +  +    +E+  +  S ++ +   +  ++  R++ L  Q++E  + LEE++
Sbjct: 980  SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1039

Query: 3705 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
              L + ++ + +   W        K     +   D+ ++ K+LK   +L+ D++     L
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG--DSEILKKQLKQCRLLVSDIQTIQPSL 1097

Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV--RKEHMT--LEKGLHLAKE 3820
             S  E G++     E   A RL  E+ +   Q   +   V  RKE +   LEK + L K+
Sbjct: 1098 NSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKD 1157

Query: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
             S+  + +TQ   EY E     + P     E +  + + K  ++     E  VK + E  
Sbjct: 1158 LSEMHEWMTQAEEEYLERDFEYKTPD----ELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1213

Query: 3881 EALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW 3937
             +++     V    LK +++ L ++YQ LC+       +LE       +  S L++  KW
Sbjct: 1214 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1273

Query: 3938 LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI-GQCAD 3996
            L ++  +L   + +   + E I++ L   + +M      ED  N +++   TL  G   D
Sbjct: 1274 LNEVEFKLKTTENIPGGA-EEISEVLDSLENLMRHS---EDNPNQIRILAQTLTDGGVMD 1329

Query: 3997 HL----------------------QAKLKQNVHAHLQGTKD----------------SYS 4018
             L                      Q  L+Q++ +  +  K                 +Y 
Sbjct: 1330 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1389

Query: 4019 AICSTAQRMYQSLE-------------HELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-- 4063
            A    A +M Q  +              E++KH   ++  Q+  + +   Q  L+     
Sbjct: 1390 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449

Query: 4064 ----QPPLSRAEAIKQVK--------HFRAL------QEQARTYLDLLCSMCDLSNASVK 4105
                Q P +  + +++ K        H  AL      QE  ++ L+  C     S + VK
Sbjct: 1450 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH-CVNLYKSLSEVK 1508

Query: 4106 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RH 4160
            +  + + +T + I QK  Q +N  +  E +  LK   +EL   + +  QQL+   +  R 
Sbjct: 1509 SEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1567

Query: 4161 SELELNIAQNMV----------SQVKDFVKKLQSKQA-----------------SVNTII 4193
               E+N+    +          S V+     L S+ A                 S+  + 
Sbjct: 1568 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1627

Query: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVE 4250
            E +  +  K+E+    +++ LN  W+ +  ++    NL L+ ++ ++      D      
Sbjct: 1628 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD------ 1681

Query: 4251 VFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
              + K+  + D L   S+ +      + LK+L   L + +  ++  +DQ   ++ +    
Sbjct: 1682 -HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1740

Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIA 4368
             ++LV+ Q S L  R+  +   IK  K  + +  LE+ N    +  E +E   +Q  N+ 
Sbjct: 1741 CRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1800

Query: 4369 EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALS 4428
            E        D  +++  D+     EL  +   L+  I D           +R+ I+    
Sbjct: 1801 EE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQ 1844

Query: 4429 DAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD 4488
              Q+  N L DL  QRRK   KAL    Q+     QA   ++  +      + +  LP+ 
Sbjct: 1845 LLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEP 1898

Query: 4489 -----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
                 + +  +  +  +  L   + +  GL   G  +  E T+ + S+   +++   + +
Sbjct: 1899 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 1958

Query: 4544 DSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLM 4592
              +     H ++E           LE + V   +  E    +   L+   ++  P++   
Sbjct: 1959 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CA 2017

Query: 4593 NESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQF 4652
             +  +L  Q    +NI +   +    +  +       L S   V+   L E L+ L  Q+
Sbjct: 2018 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQW 2077

Query: 4653 NVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE---- 4708
              +  + KD+  +   ++   + +   I++  Q L+E E QFLR +++P +    +    
Sbjct: 2078 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWY 2136

Query: 4709 ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ 4768
               LQDG       V  L    +E+ Q+      T      +K+  L   +  + +Q   
Sbjct: 2137 LKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSD 2193

Query: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4828
            R   LE+  +   E ++   +    L+         N  ++P E          G  Q  
Sbjct: 2194 RKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQL 2238

Query: 4829 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4888
               L++V + +E+L     PL  +    Q+    G + +      E   + E+++ Q+  
Sbjct: 2239 KEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2292

Query: 4889 FQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK 4947
               ++SR+L   +  ++A++     L+  L+D++E++  + +    +++ L I N  +  
Sbjct: 2293 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ- 2351

Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQA 5004
                                    E   D+QE   A++ +Q  + EI S+ Q  Y+    
Sbjct: 2352 ------------------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--- 2384

Query: 5005 ANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
                                 + A + +K  +E  S+E    +  L+EL +    L P +
Sbjct: 2385 ---------------------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2423

Query: 5064 KPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
               G    +      Q V + E    ++   S   +++         D+ +A  E+ + +
Sbjct: 2424 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWL 2478

Query: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDA 5176
            +  ++ +    ++      +  E + + KA +  +     ++  L   A  L+ KT N  
Sbjct: 2479 SLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 2537

Query: 5177 SKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5236
            ++  ++  +  +  +W  ++   Q++ + L + + + T +    ++A +++ Q + KL  
Sbjct: 2538 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 2597

Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
                  +   +   +        +L Q Q+ + +     L +L+D +A    ++   +  
Sbjct: 2598 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHM 2653

Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
            IT          E +  + + + + + +RE            ++ET   L     +    
Sbjct: 2654 IT----------ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLD 2689

Query: 5357 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQD 5415
            LE+    LTEA      ++    +++                 L E +  +K +  Q QD
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQD 2732

Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSK 5475
               E+E        L    QK+ + L               +   D  +L   LD  N K
Sbjct: 2733 LQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFK 2777

Query: 5476 LMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5532
              EL      ++  LE +    K L   + +L  +  Q      +R + +      +++ 
Sbjct: 2778 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQ 2836

Query: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKL 5590
            N++     + ++  + +   T+         +     + L +E +E+  E  A  +T  L
Sbjct: 2837 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2896

Query: 5591 QYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK--- 5643
            +       T  EK++   A+  R+ +E  +    RLQ LQ+A    D+K  +AE+ K   
Sbjct: 2897 RKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSW 2952

Query: 5644 ----------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
                      LQ  LE+ +A       G ++ LKE +SH   L  ++ +L      +QL 
Sbjct: 2953 QPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLS 3002

Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
               L   ED+     L   A+   E+  R  H A
Sbjct: 3003 PYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3033



 Score =  157 bits (397), Expect = 4e-37
 Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)

Query: 5520 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5577
            S L ++  +L+ Y   LE +L W+  A+  + A G I+ N    +++Q+  H+  +    
Sbjct: 324  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 379

Query: 5578 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5636
            ++ +    +   LQ  + +  T K+S+       E +E   ++  R + L+ A+ + +  
Sbjct: 380  DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 436

Query: 5637 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5695
                L  LQ   L++    LT  E     ++E+      L  ++E LK +VQ  ++ Q  
Sbjct: 437  LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 491

Query: 5696 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5755
            L   ++ V    L H  + + E +      A+                E+++K L     
Sbjct: 492  LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 533

Query: 5756 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5802
               R  ED+ V   +I    Q L        A +S  E+   KI   G+++Q   L+S  
Sbjct: 534  NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 593

Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5856
            K+  +KA       ++ ++  L +       +LL T   + SV   T        RC   
Sbjct: 594  KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 645

Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
            L    E+S      ++IS       PS    T       +   + +  +  Q +     P
Sbjct: 646  LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 699

Query: 5917 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5976
                 Q   +  +       + +L  SW T    + +     +    ++  + D    + 
Sbjct: 700  PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 752

Query: 5977 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 6036
             K+ AIE + +E                    +   LQD     Q+ L E++V+E   AD
Sbjct: 753  EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 791

Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
              +Q + Q            +  +     QLL E+LN  LE Q    A      +  +L+
Sbjct: 792  SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 835

Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
                + +  L    + P EP  +++QL  C++ +  +      +  L + +  L  +G+ 
Sbjct: 836  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 895

Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6216
                +A+ +A                 H KQ+     A+EKE   +    T  P   +  
Sbjct: 896  PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 939

Query: 6217 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6264
              A  TW QQ ++ L          + +EQ L E ++L  S+  +   +      ++  +
Sbjct: 940  MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 999

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6295
             +   +   K     +E+    +K S+         E+QM                    
Sbjct: 1000 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1059

Query: 6296 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
                + +W +L      K++L Q  L     Q +    N +  G    K +   +  S +
Sbjct: 1060 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1119

Query: 6352 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6406
             + L  LN  ++ +  Q    K   +  +     L   +S    W+   EE         
Sbjct: 1120 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1179

Query: 6407 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6462
              P+E +  +   +   ++ ++   ++    +   ++ +QA P     ++ ++  L  L 
Sbjct: 1180 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1236

Query: 6463 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6506
                 L + +N +C          H++   L++   + N+++    +       A+    
Sbjct: 1237 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1296

Query: 6507 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6564
            +L  L N+    +    QI  + Q        D G+++           +   +EL    
Sbjct: 1297 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1340

Query: 6565 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6624
              + EL      R+  L Q++    + E++L  + + L    +++A      ++ K +  
Sbjct: 1341 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1396

Query: 6625 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6684
            Q+  + ++    L SH I  E + +        +  +    +++Q     K+     ++ 
Sbjct: 1397 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1450

Query: 6685 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6744
              + +  ++ ++  QE    L+ V+  +P++      ++ +  ++    +L  SL+E + 
Sbjct: 1451 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1509

Query: 6745 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6801
            ++  V+  G++++         +L+ ++  L   +     K+++   +LE  LK   + +
Sbjct: 1510 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1569

Query: 6802 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6857
             E   L  WL +        T   +T    +E +  +L++ + + K    E++ Q     
Sbjct: 1570 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1621

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
            S+   G  L  +       +  +LS ++S W  + +        L + Q         + 
Sbjct: 1622 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1681

Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6977
             +  WI   + ++ + E         K   +     K  K ++N  +  VD        +
Sbjct: 1682 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1733

Query: 6978 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 7036
             +   +  R        Q+  +N  +  +   + T K  +    L+   ++ +++Q L  
Sbjct: 1734 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1787

Query: 7037 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7087
              E +        E+   +     ++ +V+  L+   +L+  I  + K  E KI+Q  L 
Sbjct: 1788 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1847

Query: 7088 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7142
               N  +D+ S       E+   W         L   L  +  + +S     D+     I
Sbjct: 1848 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1907

Query: 7143 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7197
            +  L + +  L+  R     L     A+ V+   +Q     L K+ R ++ KF       
Sbjct: 1908 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1962

Query: 7198 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
              + H    ET+    +++ +  + +    + E    S+ALL++ Q              
Sbjct: 1963 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2011

Query: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
                              A D  A   +D     + L  +KDSL       + +  +  A
Sbjct: 2012 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053

Query: 7317 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  SA   +++ L + L  L+    K       +Q      V  +  F   ++    W+ 
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7427
            EAE+ L+      + + +  +  ++EL+  + +  ++   L+   E +  +    D  I 
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2173

Query: 7428 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
             +++ +LN  W  +  Q ++R  +L+   + L + Q  L +   W+E   + +   ++ +
Sbjct: 2174 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2230

Query: 7484 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7540
              G  Q L E+    +L   E+  RQ IL  +   G  +L    +  +++D+   KL   
Sbjct: 2231 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2290

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
            + QW  V R   +++G I++QI+   +  +  E L + L  +          + I  Q  
Sbjct: 2291 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2350

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7660
            +    +VQ  E     +Q      +  G+ L    +  A   ++ +L ++  +WK+ +  
Sbjct: 2351 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2408

Query: 7661 LEEQKKKLAFL--------------------------------------------LKDWE 7676
            L+E + K   L                                            L D+ 
Sbjct: 2409 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2468

Query: 7677 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
            +    + D L  L    K    +   L D +E +  ++   ++LE       + +T    
Sbjct: 2469 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2528

Query: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
            LK+  S   + +  +I+ +R+E +Q QW+E+   L  RRQQ+ E L +   + E  +E  
Sbjct: 2529 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2585

Query: 7794 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7849
            + L Q  +K+   + G   ++ + +K+   K   +++   Q N      +  +L +    
Sbjct: 2586 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2645

Query: 7850 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7909
                ++      +N  W+ +   ++ R   L+ET   +QQ   ++     WL   E+E  
Sbjct: 2646 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2703

Query: 7910 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7962
              ++ D+   E        ++  + + Q+LQ +IE H+    ++    + +L   +  + 
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2762

Query: 7963 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 8022
            DA    +Q+   N++ +W  +   S+  R  +E +   W++          WL+  +   
Sbjct: 2763 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2820

Query: 8023 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 8063
            +  +  G  +   +++     AF+R++                    + L  LE + ++ 
Sbjct: 2821 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2880

Query: 8064 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8122
            R L  E R  +    L++   E N  W+ L        R++   + + +E + A D    
Sbjct: 2881 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2936

Query: 8123 WLTEMDLQLTNIE 8135
               E+DL+L   E
Sbjct: 2937 ---ELDLKLRQAE 2946



 Score =  142 bits (359), Expect = 1e-32
 Identities = 456/2427 (18%), Positives = 928/2427 (38%), Gaps = 370/2427 (15%)

Query: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
            + TKE   QLH    + +++T +     E   +        ++  +     +    S + 
Sbjct: 251  KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 310

Query: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
            +  L+  E   F    +E E+ +L+  +++L     W  S     +      + V+ V  
Sbjct: 311  SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 368

Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
              +  T E  + D+      + +  + G + +   +  E E    E+ + M  L      
Sbjct: 369  -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 425

Query: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
            +R   M  +  LH  L    + K K L  W+ + +E     EE  +  +L + K Q+ ++
Sbjct: 426  LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 485

Query: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
            K LQ+ +   +  V S+            +   A LE                      L
Sbjct: 486  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545

Query: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
            +QD+ LK  ++ + Q  +    S  ++ V  +     KD  +  S LQ       ++EK 
Sbjct: 546  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 604

Query: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
              Q  G+L +   DLL T   +++TQ+    +A ++  A   D L     K    I Q  
Sbjct: 605  KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 661

Query: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
               Q  L Q          ++ + + +  Q + +  + EL        RQ T+       
Sbjct: 662  TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 715

Query: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
                  +  +W++  +  L+ SP+  + R E           AI++ K   FR LQ+ +R
Sbjct: 716  LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 774

Query: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
            +   L+  M +         A  I+Q  + +  + ++   L      W E ++     + 
Sbjct: 775  SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 829

Query: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
             LQ  +Q     +     +  +  E    ++ +   KD V +L   Q  +  +  +   L
Sbjct: 830  QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 889

Query: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
             +K + P   +       NH    + D+  Q+    LQ   D      Y + M+ +  ++
Sbjct: 890  KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 947

Query: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
            ++  T+     L+ +D E     L  L+ L  +LQE++  +  L    ++M +    +  
Sbjct: 948  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1007

Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
               + +   +E RW +L   +    Q     + +L  +Q+  Q L +W  E    + E  
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067

Query: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
                  ++ +  L     + S+++  Q  L S+ +   ++  +        ++  L +  
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1127

Query: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
            +  + +   V  R++ L   L +       + +    + Q E + + R+     PD++ K
Sbjct: 1128 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1187

Query: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
             V+  K A       +A +K     V  + AQ   + +E  ++E       L+ L + Y 
Sbjct: 1188 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1240

Query: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
             +  + + + + LE+            +KA  WL + +       N+   + E+   L  
Sbjct: 1241 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1300

Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
             +N++  S +  N +  L +T           D   + E +N     FN        ++ 
Sbjct: 1301 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1344

Query: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
            ++ E  + R++   L+E + QS  E E              ++E+L+  D   A     A
Sbjct: 1345 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1387

Query: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
             + + VD     +E      Q  Q D   H ++L                      ++H 
Sbjct: 1388 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1423

Query: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
            +  +  +R L  +   Q K+ + ++    K +++   A     LQ+S ++L  V +HL  
Sbjct: 1424 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1477

Query: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
              P L+  + E  +  +QS       L  ++ E  +E E       ++VQ    QTE  +
Sbjct: 1478 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1531

Query: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
             LD   RV A       L L+  ++     K+   +++++  L++   +    KE     
Sbjct: 1532 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1576

Query: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
            + L + D+E  L + S ++G   ++   +   +AT  EI  Q    +   +V +A    L
Sbjct: 1577 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1634

Query: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
               + L++     L  N + V S AEE L   +E+    + F  N++ +   +   D L+
Sbjct: 1635 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1694

Query: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
                  KP  KED+ +++ + EL   R   DS    D      A   D+ +K  E  I  
Sbjct: 1695 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1751

Query: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
            +N     +S    +KT  +     E E+  S+ + L+  + +  ++ V L+E+     K 
Sbjct: 1752 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1807

Query: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILE------------------DA 5209
             N+ ++ T+   +     + QR T  R R   + ++++L+                  + 
Sbjct: 1808 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1867

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
              +W  +  +     + +D ++ KL  S  E   + ++  +         EL++++  L 
Sbjct: 1868 SHQWYQYKRQADDLLKCLDDIEKKL-ASLPEPRDERKIKEIDR-------ELQKKKEELN 1919

Query: 5270 MLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQE 5321
             +R+Q   + +DGAA    PT  +     +EI +   Q R LN  +   V+    +V  E
Sbjct: 1920 AVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE 1979

Query: 5322 LKDREM------VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQ 5372
                E+        T+I  V   + E ++ L  P +   + +   ++ + L     + +Q
Sbjct: 1980 DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQ 2039

Query: 5373 NIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQ 5428
            +  ++     +K   L +  P E + LQ A   LD    K+    +D+    ++S    +
Sbjct: 2040 SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2099

Query: 5429 ELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAA 5482
                 I K+     T   +   KT   +N   AK  +  L E  DG   +   +  L+A 
Sbjct: 2100 RFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNAT 2157

Query: 5483 VQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 5541
             ++ ++Q+ +     L +K+G L    Q+  +Q  +R  +L +  + L E+   L   + 
Sbjct: 2158 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2217

Query: 5542 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSV 5596
            W+E+A  +A   +      QL+E+    + L+EE       L+ + E      +    S 
Sbjct: 2218 WLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISP 2277

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE------- 5649
               +K+  ++ +   +  ++ + +  +   ++   KD+ + E +L+ L+  L        
Sbjct: 2278 EEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2337

Query: 5650 ------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MES 5681
                                Q T  + +  +  ++E LS  QHL  E          +E 
Sbjct: 2338 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2397

Query: 5682 LKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAA 5736
            L  + +AV      LR  + D+   L    A+    + L  +    + TAI +  +  + 
Sbjct: 2398 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSL 2457

Query: 5737 VVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 5793
            +++      + +    L   +    + I+ + V   +++++   I + +   Q ++  + 
Sbjct: 2458 MLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP 2517

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTE 5820
            Q+  L +  + L  K  +      +T+
Sbjct: 2518 QLEELITAAQNLKNKTSNQEARTIITD 2544



 Score =  134 bits (337), Expect = 4e-30
 Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)

Query: 7330 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7389
            SQHL A E       +SL    ++ + +  +LE + +W++ AE+ LQ Q    S+D+  +
Sbjct: 311  SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 367

Query: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7441
            +++    +G M+  ++    +  + +LG +L    K       E++   NL N  W  + 
Sbjct: 368  KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 427

Query: 7442 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7499
              + E+ S L   L+  Q   L++   W+    +  +K+  E  G + + L  Q + H++
Sbjct: 428  VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 487

Query: 7500 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
             Q ++   Q     + H +++  +   +       ++    L +L ++W  + R  + R 
Sbjct: 488  LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 543

Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
             ++   + +WQR  E       WL E                       D V        
Sbjct: 544  VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 582

Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
            + Q   + +++  K  +L AD   +     +L  +++   S +++ +   +K    L ++
Sbjct: 583  KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 639

Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
             +C   +   LEK                           ++  AV +    LTQ +++ 
Sbjct: 640  ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 674

Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
            +T++   + + I        L++   EEL      +++QI        V SE  K L   
Sbjct: 675  ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 719

Query: 7796 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 7847
            +T++ S ++++  +L        +K     D +E++ AI +E   K +  Q   R A+A 
Sbjct: 720  ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 779

Query: 7848 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 7895
             E   +E      I+    ++N RW     L++ R+  L+    ++A    +QQL++  +
Sbjct: 780  VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 839

Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
            +   WL    +  ++P    S   +  + ++N    LQ  IE+        L +  + L 
Sbjct: 840  TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 890

Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
            +        + D +   T +  + + ++ A   E +   +    +  ++ +  S    W+
Sbjct: 891  EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 947

Query: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8075
            + SE   + P  S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +
Sbjct: 948  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1007

Query: 8076 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 8134
               +    E   RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L    
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067

Query: 8135 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8193
                + ++  K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL 
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1127

Query: 8194 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 8248
                  CQ+V+ R E     L + + L  D  ++ +   + E+     D  +        
Sbjct: 1128 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1179

Query: 8249 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8308
               +    L  ++ +  R++   +   A V            L+  + S +++A P   E
Sbjct: 1180 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1226

Query: 8309 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 8354
              + + +     Y      L+G    LE          S + +  K L++  F+++ TEN
Sbjct: 1227 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1286

Query: 8355 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 8414
            I     P G E             E S  +DS   LE+ ++  E++ P  + + +     
Sbjct: 1287 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1324

Query: 8415 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8462
             GV+D            RW  L  +A+ ++  ++Q++Q  Q+              TE+ 
Sbjct: 1325 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1370

Query: 8463 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 8522
            L  +Q      D Q       K+   Q   + +K   +  +L S E +  + K+    ++
Sbjct: 1371 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1427

Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 8579
                      RV S ++  +  LQD  M+ + F + ++    + E+   +D  K  +  +
Sbjct: 1428 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1480

Query: 8580 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 8638
            ++ +++ E++Q      + +   L E +  V  +     Q++   +  +  E  E+V  +
Sbjct: 1481 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1540

Query: 8639 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 8679
                  L  +V+   ++LEK L +S   +     L+ W +A +++
Sbjct: 1541 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585



 Score =  119 bits (298), Expect = 1e-25
 Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)

Query: 521  SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
            S +++W+ +   + S+ QL       +E          S   EQ    Y +     EM  
Sbjct: 941  SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1000

Query: 572  KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
            KA   +  +        E   +W+ LS ++      LEE ++   +  N + +L+ W+ +
Sbjct: 1001 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1058

Query: 632  AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
             +  L +       SE  KK     R L   IQ       ++N+ G  +    +   +  
Sbjct: 1059 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1118

Query: 679  LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
            L+ +L  LN +W  +  +V  YA+ + +    K   +  V+L    +E H+ ++    E 
Sbjct: 1119 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1172

Query: 735  LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
            LE  F       ++  +++++  ++     +A+ K++T++ + +  ++P           
Sbjct: 1173 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1225

Query: 790  SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
              LK++L  +   Y  L          LEE+          L K N+ +  +E       
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1278

Query: 850  LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
             FK K             T   I  G++ + + + +L N+++H +    Q +I    +  
Sbjct: 1279 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1324

Query: 909  QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
              ++ +  +  + +ET +   ++  E     +K+L   ++ ++   + E+ L    E  +
Sbjct: 1325 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1379

Query: 969  QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
             +D++ L A++   D++      QE Q +Q  +      L +  K  QG+     +  +I
Sbjct: 1380 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1436

Query: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
            DV + +          ++  + +L  +  + E+ ++E ++   D+   HL     + +E+
Sbjct: 1437 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1487

Query: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
              V+  +   V       + +L E+++ ++   +        K  E+P +  +  +    
Sbjct: 1488 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1542

Query: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
             ++E  + ++  + QL+  K   +      E+    E +      +TKR   +  + S L
Sbjct: 1543 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1599

Query: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
              +V    +++ E +KQ   L  ++   +AL T+L + E ++ +    +    I V +  
Sbjct: 1600 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1659

Query: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
            EE ++   E Q+  E         T+ + +A  LL   ++K         KR+ A+  D+
Sbjct: 1660 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1719

Query: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
            + ++   +     L     +  RKL        +  E   R   ++     R +T K ++
Sbjct: 1720 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1770

Query: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
             ++ L Q  S  ++ L     E L +E++Q     +   +  +  +N       +  G  
Sbjct: 1771 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1825

Query: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
             +Q +  + K     IK+Q+ + +    +D+++    K      +W  +    + L   +
Sbjct: 1826 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1885

Query: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
             + EK+L +L       + +I +I   +Q+ + +L+++     GL E+  + A    Q  
Sbjct: 1886 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1943

Query: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
             +     I++K  Q RR        +RE    +  E   L        +   +  + Q++
Sbjct: 1944 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2003

Query: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
             E E  L  P        + +K  +   ++  +L+  S  I       TA   SA  V  
Sbjct: 2004 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2062

Query: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
            R    +  + L  Q+E + +  K+RQ   +  +  W+R   ++  F  WL   E      
Sbjct: 2063 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2122

Query: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
            ++  + +  K +  L   + LQ+ +  + +    L    E +   +SK D  +++  L  
Sbjct: 2123 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2179

Query: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
            L+ RW+++ + ++ R   L+       +F   L  F +W    L E    + I +   + 
Sbjct: 2180 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2235

Query: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
               + K+   +V+    EL   QG L +L   G           E+   L+ K +     
Sbjct: 2236 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2293

Query: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
            + + S+ +  +Q  + + + +  Q    L  +  QL   +   + + +N+ ++  +    
Sbjct: 2294 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2352

Query: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
               D  +   A+++    ++ ILSK Q+  K   + Q    +   + L  E + +  LL 
Sbjct: 2353 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2410

Query: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
              +++   LA           + +  +    + + T   +L+ P+   L+   L  FN+ 
Sbjct: 2411 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2470

Query: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
              EL        WL     Q+ +       +++ +IN + +    T + + + + Q   L
Sbjct: 2471 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2519

Query: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
             +L+   QNLK+  S   + A ++I  R                E  +N+ +  Q+ L N
Sbjct: 2520 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2562

Query: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
                 +  L+E+ K             +ST  +WL+  E+ E+ + + R  L  W +   
Sbjct: 2563 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2603

Query: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
            T D I+        Q+A+++    +N+D  N L A +LL+++ ++   K   + E     
Sbjct: 2604 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2661

Query: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
               +H +V++ +   +  ET   LQ    DL + L    E  E     L+D    +T+ E
Sbjct: 2662 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2714

Query: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
            + + D                     E +K+ +D+Q E+++      +  EN   + R  
Sbjct: 2715 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2758

Query: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
              S +   L R +  +  K   + +     ++ L+ S +  K    S+QE   W      
Sbjct: 2759 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2818

Query: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
                   +G    A  K++       + L+ K   + + L++V           L+ + Q
Sbjct: 2819 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878

Query: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            E + L      Q V+  +++Q  + N E++         ++ + +    L   ++   +L
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2938

Query: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
            +L + + E  + + + +G+    I   ++ + KV+   GE+   +E++  ++   + L+ 
Sbjct: 2939 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 2996

Query: 2587 EG 2588
             G
Sbjct: 2997 LG 2998



 Score =  114 bits (286), Expect = 3e-24
 Identities = 347/2017 (17%), Positives = 774/2017 (38%), Gaps = 287/2017 (14%)

Query: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
            Y + L+EV  WLL     L A   + ++ +E +  Q   H+  M ++   + R+ N+   
Sbjct: 336  YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 394

Query: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
            G  LIG        KL ++    +Q   +  ++       A    QS  H +   +  Q 
Sbjct: 395  GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 448

Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
             L++   WL+  +       + PL     +  +QV+  + LQE      DL      +++
Sbjct: 449  -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 501

Query: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
             +      D    +        Q + L   W  I     + W+ LQD   + Q +     
Sbjct: 502  LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 558

Query: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
              E  +    +S+ +D V K+ +      N ++  + KL   +   E K           
Sbjct: 559  --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 605

Query: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
              +QS       ++DL  T          E +L+ F   WDNL +   +STA   +A+  
Sbjct: 606  --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 663

Query: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
               +L +      +  +  ++Q +++H     +EL        ++R   ++  I++++ V
Sbjct: 664  TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 718

Query: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
             +T             EL  W        +EA+ QSP     +  +       S+L+ K 
Sbjct: 719  DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 755

Query: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
              ++    +  R + D   + + ++++ +++  +     +D + Q  + LN       + 
Sbjct: 756  NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 810

Query: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
            LSE+  +L     +    +Q+QQ E+     E+   +       P  +  Q+K CK    
Sbjct: 811  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 870

Query: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
             L   Q ++  L  Q   L ++                  +Q  S+V  + +ELQ+++D+
Sbjct: 871  RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 930

Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
            +                    ++E       W++Q++  ++ P++++  +   +  +L +
Sbjct: 931  L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 973

Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
             Q +     E ++ L  L  T + +     +E+   Y SE    +  ++  + +   +  
Sbjct: 974  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1032

Query: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
             K++E +   ++  + I+   + ++E++  FL+  + P  L   E L  Q   CR ++ +
Sbjct: 1033 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1089

Query: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLVTLYHR---LKRQ 4765
            +  +  +++ +N+  +  ++  +P               Q D M   V  Y R   LK  
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV--YARKEALKGG 1147

Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL 4825
             E+ VSL +D +   + HE M Q  E  L+  ++ + K  +E   A E++K     A   
Sbjct: 1148 LEKTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA--- 1199

Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
            Q     +K +T  +  +     P+A E  + ++++     + L + +       E     
Sbjct: 1200 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1259

Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMN 4942
              +  + + ++  WL  V+ +L     +    ++I E    +  +  H E+  + +RI  
Sbjct: 1260 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI-- 1317

Query: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
                                L  +L +   +D  I E L T  +   E++ +  R  ++ 
Sbjct: 1318 --------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1357

Query: 5003 QAANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 5060
            + +    ++ ++ L L    L    +     +   ++      +      +L S   +L+
Sbjct: 1358 EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLE 1417

Query: 5061 PLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELM 5117
             + K    ++  Q+V S    +Q+  +D   +  L Q+        Q+++   +EV   +
Sbjct: 1418 EMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1477

Query: 5118 NDTEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
               E K  E  ++++  +H     + LSE K+ V +V     +IV  ++  +  E     
Sbjct: 1478 PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE----- 1532

Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
                 L   +T +   +  L A   ++++ LE  +        ++   TE +     +L 
Sbjct: 1533 -----LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1587

Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
              SA +   + L + + +      E+E+Q+  L     ++++ + +      G++  L++
Sbjct: 1588 KRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVE 1642

Query: 5296 E-ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
            + ++ +    + +  + +    L+ +  K  E  +  ++ +  W+ +    L     +  
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702

Query: 5355 AQLEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALD 5406
             Q E+ L+ L  E  + R  ++   ++              L     SEL+ + A ++  
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHR 1762

Query: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KV 5464
            +K   +    +KE+EQ  +              D+  +L  L+A+    V  K +   K 
Sbjct: 1763 IKT-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKD 1807

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
            + E+ +G   +L++    +Q+ +    +  +   K+  +L +     ++   ++  K   
Sbjct: 1808 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKAL 1865

Query: 5525 AASHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE 5582
              SH   +Y    + +LK ++   K LA       S  + R++         + KEID E
Sbjct: 1866 EISHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRE 1910

Query: 5583 LEAMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIR 5623
            L+   E+L  +           +    E    Q+++  RE E            Q+  +R
Sbjct: 1911 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1970

Query: 5624 LQNLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5675
             + +    +DM          +  E+  +  AL + +  L +P++     ++     + L
Sbjct: 1971 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2030

Query: 5676 LSEMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5732
             +  +SL+    ++  +   ++A       V  + L  A  +L  +  ++      +   
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2090

Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEEL 5784
               +V ++ ++  ++K   Q +  A + +    +  +         ++ELQ  I + + +
Sbjct: 2091 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTV 2150

Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
             + +    E+I   +SK     ++ K  ++ L   EV
Sbjct: 2151 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2187



 Score =  108 bits (269), Expect = 3e-22
 Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)

Query: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
            ++  ED++  + L+++  N D    A +EV +W+    D L+  G + + +      F  
Sbjct: 314  LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 373

Query: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
            HE                  LG +L    ++     + +Q     L+     L  A  ++
Sbjct: 374  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 433

Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
            Q++L   ++D +   + L+ L  W+ + EE       +   +   +   +E+LK Q+ + 
Sbjct: 434  QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 485

Query: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
              +  DL+    R+N L + + + D+           ++++ L   W+ I   T +R+  
Sbjct: 486  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545

Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
            LQ  LL+ Q   E+   +  +L + E  +    +  ++            Q EM S  Q 
Sbjct: 546  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 594

Query: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
            L  +  D    LE+ +      ++LK  LLS      +   Q+    +D+  R W     
Sbjct: 595  LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 645

Query: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
            + +KL K   ++S      + +    L Q   +     V  +E++ ++     +      
Sbjct: 646  LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 701

Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
            K+  ++ DS     L  ++ E+   W + S  + +  +   F      + E   +D  EK
Sbjct: 702  KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 754

Query: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
            +   +++ ++                ++L++A  S        +L++  ++  ++AD I 
Sbjct: 755  VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 794

Query: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
              +E+   L  +W E C  LS       ERLN W  +          L Q+E   +   +
Sbjct: 795  QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 843

Query: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
             L I+          + ++ I ++   +L  +  ++ +   +S A +        ++   
Sbjct: 844  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 903

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
                + ++ +   + AR K+L+     +  +   + MS++RTW+   E++L+ P +    
Sbjct: 904  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 962

Query: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
            + E ++++L E Q LQ  +++  +G    L      + +    A        Q     ++
Sbjct: 963  DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1018

Query: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
             RW+ + +  +E   K+EE     +K  +     + W+        E   A   S     
Sbjct: 1019 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1074

Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
             + K++LK+       +      L  +N+  +++  E   + A  L+  + E N +WD++
Sbjct: 1075 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1133

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
             ++V +    LK  + +    +     +  W+T+ + +    + E+ +  ++Q  ++++K
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1193

Query: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
              ++E      K++ +      +I ++ P+    +++EL+ L    Q +  R        
Sbjct: 1194 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1245

Query: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
                       L+ +   LE+  A     WH+     LLS    +N  L+  +     ++
Sbjct: 1246 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1283

Query: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
              + P   + I    D   +L R  E   +  R L     +G    +         +   
Sbjct: 1284 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1343

Query: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
              L  +  +  K L+ S    Q+TE  +     +   +D     Y+    + +      +
Sbjct: 1344 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1403

Query: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
            +++  L   E SL      +  +     V+ + ++  AQ   +++ MK  L QK   F  
Sbjct: 1404 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1461

Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
             L      L + +  L  L+    S + + ++ Q+     L K++   K+ +  +     
Sbjct: 1462 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1519

Query: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
            +  Q    E+ ++L +R++ +   ++ + + + E +  L+  L   +   +  + L   L
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579

Query: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
               D    +++ +  + SNLD+E+
Sbjct: 1580 AATDMELTKRSAVEGMPSNLDSEV 1603



 Score = 65.9 bits (159), Expect = 2e-09
 Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)

Query: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
            PS+  E  +DK F    +   V L    +ALE  +  L  A D  + Q  I     +++ 
Sbjct: 310  PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 369

Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
            +  T       ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++ 
Sbjct: 370  QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 421

Query: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
                    RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L
Sbjct: 422  --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 471

Query: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
              D++ ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  R
Sbjct: 472  GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 531

Query: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
            W  +C   E+   LLQD L++ Q   E        L   +   N+I         E+L  
Sbjct: 532  WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 591

Query: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
              K L  +K +L + +  +  L  +   LL
Sbjct: 592  LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 620



 Score = 49.3 bits (116), Expect = 2e-04
 Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)

Query: 134  QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
            Q++ L   LP  Q +    +     V    P  P ++    K++   K+  L+W++ +  
Sbjct: 2244 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2300

Query: 194  ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
               KQ  IE  +KD G+  +        ++ +   L  +       N+ N E  F + ET
Sbjct: 2301 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2360

Query: 249  ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 299
            E+          V   +PD + I++      K  P        + + S++ +  + +L  
Sbjct: 2361 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2411

Query: 300  ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 321
                     PG  +   S         Q    ++  I K                     
Sbjct: 2412 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2471

Query: 322  -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 376
             E+  W+   ++ +   +++  +L+D  +     K      E +R Q+E LI        
Sbjct: 2472 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2531

Query: 377  KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 424
            K S  +A          ++  WD V   L +   QL++ L         WL   E A   
Sbjct: 2532 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2587

Query: 425  ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 481
                R ++   +    T + IQ+K+ + K L ++     R +       +   + +  D 
Sbjct: 2588 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2643

Query: 482  LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 533
              D   + H ++     S   +H    E    LE  +RLL    L   K  +W+ +    
Sbjct: 2644 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2703

Query: 534  ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 579
             +V Q        +E+SK                E +   Y  L + ++  +++    ++
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2763

Query: 580  AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 639
            A  + + ++    +W  L  +  ++RS LE     W R   ++  L  WL+  +  L++ 
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2823

Query: 640  ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 695
                 DF       +Q+   ++ A    ++T + ++   L+   + L  +      +L+ 
Sbjct: 2824 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878

Query: 696  EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 748
            E ++     +A  + R+ ++  + V T    L+  + +  +K+ E LE         +Q+
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2930

Query: 749  LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 808
            L++    + +   Q ++I        K S Q  G  +  ++    E++  ++   +PL  
Sbjct: 2931 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2980

Query: 809  ESQQLLIPLEELEKQMTSFYDSLGKIN 835
              ++ +  + +L +Q+T+    L   N
Sbjct: 2981 --KENVSHVNDLARQLTTLGIQLSPYN 3005



 Score = 35.4 bits (80), Expect = 2.5
 Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)

Query: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
            ++   WE L    ++ QR + E LER Q+ Q++   +  K+   E+        G     
Sbjct: 2902 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2961

Query: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
             + +H    +AL  EI  L++ ++ + + LA +L +   +  P       STL  L  R 
Sbjct: 2962 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3016

Query: 6055 STIRMKASGKRQLLEEKLND 6074
              +++    + + L E   D
Sbjct: 3017 KLLQVAVEDRVRQLHEAHRD 3036


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score =  315 bits (807), Expect = 1e-84
 Identities = 628/3214 (19%), Positives = 1227/3214 (38%), Gaps = 521/3214 (16%)

Query: 23   DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
            DE+E VQK+TFTKW+N+  +K     + ++LF D++DG +LL LLE L+GQKLP E+G  
Sbjct: 7    DEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65

Query: 83   MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
              R+HA+ N+  AL+ L+   + LVNI STDI DG   + LGL+W IIL++Q++ +  N+
Sbjct: 66   --RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNI 123

Query: 143  PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
                                         +    Q N++K LL WV+ +      + V +
Sbjct: 124  -----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNVIN 154

Query: 203  FGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPEDV 261
            F  SW  G+A +++IH+ RP+L D  +V   +S  + LE AF IA  +LGI +LLDPEDV
Sbjct: 155  FTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDV 214

Query: 262  DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFK 321
            D   PD+KSI+ Y+    +  P     S +  ++ E+LP  P          +E+     
Sbjct: 215  DTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQLH 265

Query: 322  EMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLD 381
                + +Q    L +     S+ + +++S+ + +  Y              H        
Sbjct: 266  HQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL------- 318

Query: 382  QALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANT 441
            +A   +S+    S L +  + LD+   A L  + +WL  AE  L+ +  +          
Sbjct: 319  EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDVEV 370

Query: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE-L 498
            ++ +   H+  + +  AH+     I +  ++ +    +  D+  ++ E+ + ++S  E L
Sbjct: 371  VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL 430

Query: 499  HLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQNYV 544
             +  ME     +R+L  L   + K L  W+ K   R             E +++ +Q + 
Sbjct: 431  RVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHK 490

Query: 545  SFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVEVR 602
               E+    EQ +V    L     +  ++ G    A  E  +K + +   +W N+     
Sbjct: 491  VLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTE 544

Query: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMND 662
                +L++++  W R         AWL + E  +N+                  HT    
Sbjct: 545  DRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTGFK 587

Query: 663  AGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCV 717
              N ++ +  ++  +  DL   KQ +  L    ++L   +K  +   + +     +  C 
Sbjct: 588  DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARC- 646

Query: 718  VTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES 777
                         L + LE S   +   +   +    +  VM+    + T+   L+    
Sbjct: 647  ----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ 696

Query: 778  -----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSL 831
                 P  + K      S+++++L   + E +S +      L  P   + ++  +F D  
Sbjct: 697  EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLK 756

Query: 832  GKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEKGS 876
             K+N I          + +    + AL +Q   E +       A ++   + +   +  S
Sbjct: 757  EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLS 816

Query: 877  QSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK----KF 932
            + +      +N++  ++Q +   Q+      +  +   T      +++  ++ K    + 
Sbjct: 817  ERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRL 876

Query: 933  EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTDIL 989
               + ++E+ L+I    L+EKG     L      F+   ++V   + A  K    + D L
Sbjct: 877  SGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935

Query: 990  PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-ETK 1047
            P    Q    A+R     W   Q E    +  L + D E       +E+   EL   ++ 
Sbjct: 936  PPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQSS 984

Query: 1048 LMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKE 1107
            L  Q+     +       S K P  +  K     EE+                     K+
Sbjct: 985  LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRWKK 1027

Query: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-KRA 1166
            L + +    +KL E  +K +   +       W++  +  LK    E        E+ K+ 
Sbjct: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILKKQ 1083

Query: 1167 VEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK 1226
            +++ R  V+     +  ++  L  + E   + + + + +  ++L +  K L T    + +
Sbjct: 1084 LKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139

Query: 1227 MLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF----------------- 1269
             +         KE +K  LE+ +S  K++ E  E +   E  +                 
Sbjct: 1140 QV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAV 1193

Query: 1270 -EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSR 1328
             E ++     QQK  ++      V   IAQA       P    E L+K   TL       
Sbjct: 1194 EEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL------- 1239

Query: 1329 ERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR 1388
                     T  +W     N +   + L +  +     LS+  LE  +  L + +   K 
Sbjct: 1240 --------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKLKT 1287

Query: 1389 TESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW 1448
            TE+I   AE    E SE+    +N   L + ++    Q++ L  TL +     E++  + 
Sbjct: 1288 TENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINEEL 1340

Query: 1449 DHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQ 1508
            + F S +  L      ++K L     S+   +  +  I+ ++  I+ +L++ +  + +A 
Sbjct: 1341 ETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA 1400

Query: 1509 SFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR---K 1563
               Q     E+ +I++ LT      EE+++H Q  E    +L  +   QK  +++    +
Sbjct: 1401 QMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1455

Query: 1564 IQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSSAI 1609
            + Q  + FE +L         +K+   A ET  V QE         ++L ++L  + S +
Sbjct: 1456 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1515

Query: 1610 TAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
                 + R++V      N     +   AL+  Y ++  +  ER+  LE  L   +++ KE
Sbjct: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575

Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
            ++    WL   + + +     +      ++ E+   +A Q E+  Q      + ++ E+L
Sbjct: 1576 MNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL 1634

Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
             +V  K +  +++  L  L+  W  +     + +N L       + FD+ +   + WI  
Sbjct: 1635 KTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ 1693

Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
              + L  + +      +  L R K   AE+   + ++ S +   A           +L+ 
Sbjct: 1694 ADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NLMA 1739

Query: 1844 GKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTVEA 1893
             + + C +L E     +  R  A+SH          L E  Q ++ +  +L  L    E 
Sbjct: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--AEI 1797

Query: 1894 TNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATAD 1953
               +N  E D   KD+N+   N   ++      D +        +I    +R   +    
Sbjct: 1798 QQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIKQQ 1848

Query: 1954 QLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQA 2013
             L  +   +++L   ++ +A  ++     ++ Q ++LLK ++DIE++     L EP  + 
Sbjct: 1849 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRDE- 1905

Query: 2014 LQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINRLEVTWD 2068
                 R   +++ EL   + EL  ++ +A+ +++   A A E     + +    +E  + 
Sbjct: 1906 -----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1960

Query: 2069 DTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI------- 2115
              +RL    IH  + +   ++  D+  E   + S     + + S  ++    +       
Sbjct: 1961 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 2020

Query: 2116 -KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFSLVKTDM 2171
             KD EDL   F + E+ KN  +  Q+    +D   SK    L     +         + +
Sbjct: 2021 AKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQL 2077

Query: 2172 ESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NISNLDNH 2230
            +    +W  V++  ++   R   S+  W            W       + +  I     H
Sbjct: 2078 DF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEH 2134

Query: 2231 LRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIEADLMQK 2284
             + +  LKE +  +  +   +  L++   ++ + +         E    L     ++ ++
Sbjct: 2135 AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ 2194

Query: 2285 LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNETCEALK 2340
            L   K+  E  K  L +F       ++ +N+   W  + +      L    + +  E L+
Sbjct: 2195 LSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLE 2247

Query: 2341 KVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKKHEAVSQ 2394
            +VK + +EL  +Q  +    E      +++        +LE+ L +     IK   A+ +
Sbjct: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPE 2307

Query: 2395 LCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNI 2452
               + +A +++   LEK   +  ++     L       +       +   +    D+Q  
Sbjct: 2308 KQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQET 2364

Query: 2453 LDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQ- 2511
              +V   Q  ++ +  +GQ LY    K     ++ ++   + E++A + + L++ +A Q 
Sbjct: 2365 EIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQP 2421

Query: 2512 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL--- 2568
            D A  L +                    T+ +    Q +  K+  + K+EM    +L   
Sbjct: 2422 DLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2466

Query: 2569 -------AARESLDKLSQRGQLLSEEGHGAG--------------------QEGRLCSQL 2601
                   A  E  D LS   Q++  +    G                    Q      +L
Sbjct: 2467 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2526

Query: 2602 LTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWFWVKAIQ 2644
            +T+ QNL   T             E++++    +QEH     + L E L+    W++A +
Sbjct: 2527 ITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKE 2586

Query: 2645 DRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQ 2690
            +    AE  LG              + D ++K++++ + +     + +  +++A     +
Sbjct: 2587 E----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALK 2642

Query: 2691 ALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
             LR  + +  R +    E +   W  I       ++ LE        +     +   W+ 
Sbjct: 2643 LLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT 2702

Query: 2751 SVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY 2801
              +          + E  L+   G+KE   L+   Q +  E E HT   H L   S+++ 
Sbjct: 2703 EAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2759

Query: 2802 EKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYLDAVHEF 2852
               E        Q  L     D M     ++RK    ++ HL         ++L ++ E 
Sbjct: 2760 RSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL-SLQEL 2813

Query: 2853 TDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRLSRVE-- 2901
              WL    +EL R + + GD  A QK+           K KE +    +   R+   E  
Sbjct: 2814 LVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP 2873

Query: 2902 ------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQTQSCLE 2945
                         L PE + QN T       E ++TE + L      W+  + +T   LE
Sbjct: 2874 LEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET---LE 2930

Query: 2946 NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2979
             L        QE      +L+  L Q   +  +W
Sbjct: 2931 RL--------QELQEATDELDLKLRQAEVIKGSW 2956



 Score =  215 bits (547), Expect = 2e-54
 Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)

Query: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
            ++ L+ +    Q  + Q++++G      ++   ++    QL   W+     +S+ L+   
Sbjct: 770  FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 820

Query: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
                 W  YQ+      + LQ  +      E W +   T P E   ++  L    +   E
Sbjct: 821  -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 872

Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
            V+  S L+  +     Q + LK+       L ++     + +  + +++ A +++L  + 
Sbjct: 873  VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 931

Query: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
             D LP    +  +S + +W+   E  +   + ++ +   Y+ + + L + +  +  +  +
Sbjct: 932  FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 988

Query: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
            Q  + +++ +V ++S +   E  R  +++F E  G     W+ L   + E  Q LE  + 
Sbjct: 989  QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1044

Query: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
               + +N++Q LK W    +  LK++   +GD   ++  LK C+ L   I+  +  +  +
Sbjct: 1045 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1104

Query: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
             + G  +    + + +S + + L+EL   W ++   V   K  LK  L++  S +    +
Sbjct: 1105 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1164

Query: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
            ++ ++ +A            + + +Q  V+ ++  +++ +++E  ++      N ++ + 
Sbjct: 1165 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1224

Query: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
             P   E L   L+ +   +  L   +  + ++ + +   W     Y ++    + + E +
Sbjct: 1225 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284

Query: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
                LK   N     +E++  +    +L++     +D+   +  L + L    D      
Sbjct: 1285 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1334

Query: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +++L + +     L +   ++Q  L+  +   +   KSL  ++  +   ++ L     
Sbjct: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1393

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
            +   D + + +  ++++  +        ++ + N   E   R L   D   K++Q+++  
Sbjct: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453

Query: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
            + L      ++ +  +  L + +  L++ +  +          A+E     Q +++ Q  
Sbjct: 1454 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1499

Query: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
            H   L+++    + ++   +I  G++++++ Q ++  E + ++T L   +  +  +  +R
Sbjct: 1500 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1558

Query: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
            +  ++  ++  ++ R+    L +WL   ++     S +  +P  L  +   + +   KE 
Sbjct: 1559 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1616

Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
              + +Q  ++ ++    + L +     E  ++ +L+ +   W + + R EE    L    
Sbjct: 1617 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674

Query: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
            K  E  ++ +         AD+L  L   +KK  Q   D  + L AE     ++   V S
Sbjct: 1675 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1729

Query: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
              D    L   +      +    IS LN R       +  + H++   +  I   L E  
Sbjct: 1730 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1780

Query: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
             F   N ++ + L  +E+++ Q  ++  E+  + + +D +  +        +L Q G+ L
Sbjct: 1781 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1830

Query: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
              + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L 
Sbjct: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890

Query: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
             IE +LA  P   D    +EI R+L +++E    + + + G++             D  A
Sbjct: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1938

Query: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
               E   IQ     L +RWR I    +  RRL         EET  +  +          
Sbjct: 1939 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993

Query: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
              +L + +     L   E+    P      +    E+L K E   + + + L Q    ++
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2049

Query: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
            +I+ +     +         L++ + + + +W+ + K       R    + +   F    
Sbjct: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109

Query: 8118 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
                 WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++
Sbjct: 2110 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2168

Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8234
            S   DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2228

Query: 8235 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8291
            ++ +         L        L    L L Q +  + +    P  V S P+  +    L
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2287

Query: 8292 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 8338
               L+        +SRALP    E Q + +  ++    L      LE Q+  L       
Sbjct: 2288 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2343

Query: 8339 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 8381
                    +   +  F +Q+TE  +++K P   E+            + +   + L + S
Sbjct: 2344 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2403

Query: 8382 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 8440
            S   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L M  +L 
Sbjct: 2404 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2462

Query: 8441 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 8498
                  +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + ++ R+  
Sbjct: 2463 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2522

Query: 8499 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 8552
            +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L+D+    
Sbjct: 2523 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2582

Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
            +   E    L      ++  K     +D+      +Q    +  Q+  +L + Q  V   
Sbjct: 2583 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2636

Query: 8613 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
             D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2637 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681



 Score =  195 bits (496), Expect = 1e-48
 Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
            +L +    L  ++    ++  W+   E+    +  GE    +   K++ H  E ++ +L 
Sbjct: 329  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 386

Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
            A +  +  + Q G  L   G  +  E       +    NLL    E LR   +  Q   H
Sbjct: 387  AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 442

Query: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
              L     + L+ +  W+   ++R    E      D LE    Q+Q   +++ + E   V
Sbjct: 443  RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 501

Query: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
            ++N           SS       ++ QL+ L + WA+I   +      L+ ++ +W    
Sbjct: 502  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561

Query: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
            E +     W+   +  +        G K++  +L  LQ +    ++ E   +++ +L + 
Sbjct: 562  EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 619

Query: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
             ++L    +++S      ++ +   ++        ++K+E+          +  + +  +
Sbjct: 620  KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 665

Query: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
             + +  L + + M   ++ T ++   +K   +       +  R  ++  E+++       
Sbjct: 666  TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725

Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
            EL H+ +    A  +  E ++F+ +    +L  ++   E+E + +  +L+ A     AL+
Sbjct: 726  EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784

Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
            +         EG N D                    +  +E L S+  E C+   +   +
Sbjct: 785  EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 821

Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
                + +I  YN L            Q L+Q    A    + WL     T       P  
Sbjct: 822  LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 858

Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
             + + + L+  ++ ++     Q ++  +      + ++  KEK +G   + A   A    
Sbjct: 859  PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 913

Query: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
            +K   S++  +E  L+ +   +    ++ +   I+ W+  S+T+  + + S   Y++  +
Sbjct: 914  FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 973

Query: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
            R  E Q LQS L+E    ++     +  + +KA         S+ ++    ++  ++  L
Sbjct: 974  RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1028

Query: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
            S+   E   +L+  + +  +    I+ L+ WM +    L        D  +L  +  +  
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088

Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
             L+S  Q  +  +  +   G+ +     PE    ++ +L+ +   W  +       K  L
Sbjct: 1089 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1148

Query: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
            +G L K  S Q  + +   WM                 D ++  + E +R   E + K  
Sbjct: 1149 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1207

Query: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
               K KLL E V S         +  A        + EL+ L   Y+ +  R        
Sbjct: 1208 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257

Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
            E++     E    L+    WL + + KL     + G A      L  L+ L  H  +   
Sbjct: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317

Query: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
             +  +  T  D     + +  +  LE+    W+         Q  L ++          L
Sbjct: 1318 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375

Query: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
             L+++    +D+ L         A +      + QS+  + EI L +MKK ++   A + 
Sbjct: 1376 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1435

Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
             + ++   AQ+ L +  +  R+  +      R Q   + +L+++K     +++    +  
Sbjct: 1436 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1493

Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
            + S  +   + +K+   V ++++ V        +KT                     G +
Sbjct: 1494 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1524

Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
             V+  +    + L + +        EL + V +    LEK L L+++   +   LT+W+A
Sbjct: 1525 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1584

Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
                 L      +       ++++  K+ Q+ +   +  +KS+ E GEAL  ++  ++  
Sbjct: 1585 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1644

Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
            ++DK+  L S++  + S  +E +  L    K  E ++  +  + KW++Q      A  LL
Sbjct: 1645 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1698

Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
            + S  +   Q+    K +  E+     ++++ + +   L+    DH +       ++L  
Sbjct: 1699 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1758

Query: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
               A     K   ++I         S  Q++ + LE E+Q+ V+ ++     + +   + 
Sbjct: 1759 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1813

Query: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
             D E + +  L R + ++Q    R   E+ R  + +   +    + ++    KD++    
Sbjct: 1814 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1861

Query: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
               Q+  +A  ++  W + K    +L   L D +++L ++     E           ++K
Sbjct: 1862 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1909

Query: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
            +  ++LQ K+  +N +  +   L++                  +E   +  +   LN   
Sbjct: 1910 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1969

Query: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +   R+   + +  +  L+         T   H    ++EV  E+     D L   D E 
Sbjct: 1970 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2026

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
                 E+LK +  +LQ+    I+ +  +K   ++     ++  ++E  S L+ +W ++  
Sbjct: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086

Query: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
            + K    +   SV      +     F + +  AE+     Q P   E  K        Q+
Sbjct: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2146

Query: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
             +     +   L A  ++++ +S   DA  +   LG LN R Q + K LSD +  +    
Sbjct: 2147 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2206

Query: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
            +++ + ++ LN+ +   E+   + ++     + QQ + K+   E + LL +++  +    
Sbjct: 2207 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2259

Query: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
               Q  LK   NE  G       +  E  EQ+K E   KL++    +  V +    +  E
Sbjct: 2260 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2311

Query: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
            +E   K+L   +   ED ++  +    WL     Q +I   P           EI +  +
Sbjct: 2312 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371

Query: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
              ++   L+K Q++ ++ P  + +   L  L    + +   L E     L  K   L   
Sbjct: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2426

Query: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
               I A        V + ++ ++   S +E+ +  + E+ A     ++  T+L   + LS
Sbjct: 2427 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2483

Query: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
            L D        + G  E ++E+  K++      +  +P ++  L+T    LK +T     
Sbjct: 2484 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2542

Query: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
                  R+  +++     QEH +   QQL   LK        KEE  +V  +     E  
Sbjct: 2543 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2602

Query: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
            K       ++Q      K++   L     ++D    LA +  R        ++ ++T   
Sbjct: 2603 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2662

Query: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
                 +I + V+E E+ + ++      F  ++ + L WL   +AE +  V  D      L
Sbjct: 2663 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2720

Query: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
             +  + ++++    +++Q  +     + H   E   K  + L  +D    L+  L  ++ 
Sbjct: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780

Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
               ++++     ++ L     Q +R +   Q    WL+    EL + A  G D  + ++ 
Sbjct: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2840

Query: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
               H  F     T++    +  E   +  T  PL    G E L Q+   L  E R+Q ++
Sbjct: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2897

Query: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
            R    Q + +    ++      D+Q+  +E +E + + ++       KL +  ++K S  
Sbjct: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2957

Query: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
                      ++ L + KAL   +    E +  + + A QL   G   S   LS ++  +
Sbjct: 2958 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3016

Query: 5189 WQRWTRLRAVAQDQEKILEDA 5209
              RW  L+   +D+ + L +A
Sbjct: 3017 NTRWKLLQVAVEDRVRQLHEA 3037



 Score =  191 bits (486), Expect = 2e-47
 Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6656
            + ++L+ G  K+ G  K+    + E+Q+ ++     ++ L  + M     L R ++    
Sbjct: 392  VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 450

Query: 6657 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6715
            QK  + +  L        K   +  G +LE +          Q++L ++   V S    V
Sbjct: 451  QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 510

Query: 6716 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6761
             +V+E+        L +++ +     +++  +    + +L D          ++ L S  
Sbjct: 511  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570

Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
             S+ E  +N++      + N+M   L +L  +LK     + +S   ++ L+  +D L   
Sbjct: 571  LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 627

Query: 6822 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
              +SVT   E       R   N   +  K     S   ++   +  Q   ++ V T T R
Sbjct: 628  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687

Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6935
             ++    +Q  + L   P   +K  Q+ +D    +     I+E+ SWI+  E V+Q  E 
Sbjct: 688  EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 743

Query: 6936 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6994
             I    G     +  +K    + +   K   +   ++S   +  Q V E   +D    A 
Sbjct: 744  AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801

Query: 6995 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 7046
            +   +N  W     L++E++        +W EY+NN+       Q L+    T E  LK 
Sbjct: 802  E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 851

Query: 7047 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7104
            Q     +  ++++ LK C+D  + +   + ++E+++   +AL +  +    + +  ++  
Sbjct: 852  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 911

Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
                Q ++++     +L+ +  ++      ++     I +++ ++   LS  +L     E
Sbjct: 912  NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969

Query: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
             ++ ++  LQ LQ  L++Q+  L    +   ++ K+    ++    +  +E+  RW  L 
Sbjct: 970  IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029

Query: 7225 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
             ++ E  Q  +  +   ++ +++ +     + + +    E   A  + +I   +    ++
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1085

Query: 7285 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7341
             C  L+  + T++ SL  ++E G+++K + +   AS ++++   L+    H+C   Q + 
Sbjct: 1086 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1142

Query: 7342 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7401
             ++ +L+ G+    +  K L  +  W+ +AEE    +D  + +    +Q+ +EE+K    
Sbjct: 1143 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1201

Query: 7402 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7454
            +       +  L E     +    P+  + +K+ ++ L  ++  + ++   +   L+  +
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261

Query: 7455 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7512
               H+  ++LEK   W+   V+ + K    I G  + + E     +  +  M   +   +
Sbjct: 1262 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1317

Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7572
             I I  Q L + G +D+    N +L   +++W+ +   A +R+ +++  I+  Q   +  
Sbjct: 1318 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375

Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7631
              +++ L               I  Q A  + D+V   +     Q+  S + + E   + 
Sbjct: 1376 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1422

Query: 7632 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
            +   + G EAA Q  L++I   Q+K +  SM+    +K   F        E+ + +S   
Sbjct: 1423 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1473

Query: 7689 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
            L   K  L   ++     E + ++   C  L  ++     ++  +      +      ++
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533

Query: 7747 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7806
               L+ERV  L+  + EL  +++ R+QQ+ + L       ++   L EWL   + ++++ 
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593

Query: 7807 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
                +E M   L       K  Q+EI   + +   + ++GE L K     K + +E KL 
Sbjct: 1594 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1650

Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
             +N  W  +       +  L E    ++  D+N+  +  W+   ++ L           +
Sbjct: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1699

Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
            E ++K  +Q+E              VL   +  L+D        + DS +    NL    
Sbjct: 1700 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1741

Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 8039
             + C   +E ++                         SE    F + S  I T  A   L
Sbjct: 1742 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1776

Query: 8040 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8094
            K+ E F   + + L  LE      +N +     ++   D+  ++K+++    QR DNLQ+
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1832

Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8154
            R+T                                             + K +++K  QQ
Sbjct: 1833 RITD--------------------------------------------ERKREEIKIKQQ 1848

Query: 8155 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8214
             +   HN ++ + +Q  +         A  I  +  + +R   ++   ++   KKL  LP
Sbjct: 1849 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1900

Query: 8215 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8274
             P DE  + + + EL+      +L+   R A+ L   +  + +++   Q   S+R     
Sbjct: 1901 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1956

Query: 8275 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 8334
                    L +   + +  +    M+  +P E                 +S   S   ++
Sbjct: 1957 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 1999

Query: 8335 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
            I  + +AL     +++Q  N         P+L             C+   + + + E  L
Sbjct: 2000 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2034

Query: 8395 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 8434
            K  ++SL    G ++ +HS +T   Q+A  ++R             WE +      ++ R
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2094

Query: 8435 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 8493
              ++++KW++F+ D+     WL + E+ L + Q  E          + K  LKELQ  + 
Sbjct: 2095 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2149

Query: 8494 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
             R+ ++ ++N    E  Q  SK ++  LQ++L  +N RW  VC  L + +  L++     
Sbjct: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209

Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
              F    +  +L LE  D   +  +P++   + + L++  +Q+  +  EL   Q  +  L
Sbjct: 2210 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2266

Query: 8613 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 8659
             +    +LV+A    E  D LE K K        +   L     E+   IK+L    +KL
Sbjct: 2267 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2326

Query: 8660 LDVSSSQQDLSSWSS 8674
             D+      L  W S
Sbjct: 2327 EDLEEQLNHLLLWLS 2341



 Score =  187 bits (474), Expect = 5e-46
 Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)

Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
            E     ++  L   WE L+    EKQ  L+  L + Q +    L    TK E    K+ E
Sbjct: 413  ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 472

Query: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
             P        + Q+ +H+ L +++   Q  +N L   +   +V +    D A   AL+  
Sbjct: 473  EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 528

Query: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
            L VL +R + I      +  LL++ L   L+ QR  +EQ L           +WL   + 
Sbjct: 529  LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 576

Query: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
             ++   +   K+  +M + L     +  ++E+K  ++ +L    ++LL  L+ K+ T+  
Sbjct: 577  AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 636

Query: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
               L    R       +L+ S  ++ +A+   Q ++ Q T  E     V    T+   + 
Sbjct: 637  EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 692

Query: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
            +   +       Q++  +    E+ + L    + L S  +R E +L              
Sbjct: 693  KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752

Query: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
                     I+   AE      DA      L +++  EG  +     A +Q+  +W    
Sbjct: 753  SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 812

Query: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
            Q  S +   L+   N++      Q+ EQ+  +  N L   +       PT  KS +    
Sbjct: 813  QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 870

Query: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
               + L GL    E +  QS   K +              + H +Q   D          
Sbjct: 871  DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 930

Query: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
                         +SA  TW+   E +L +    +   E  E  L   + L   ++E   
Sbjct: 931  IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990

Query: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
             +        + +K   S+   +     + IE       GR   L S + + C +++E++
Sbjct: 991  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1043

Query: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
             ++   QN ++ L   +A+    + ++   + +  +  +Q++  +     ++     +  
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103

Query: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
            +   G K++ E +P        EL +L   +D +   + +R+  L   L      ++ L 
Sbjct: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163

Query: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
            ++ + +   +E+   ++     + +E+Q+ ++   + KE  Q  E+ + +LTE++   I 
Sbjct: 1164 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222

Query: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
                    A++KE +    L      +  R + +   LE +   W  L    ++ ++ L 
Sbjct: 1223 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1279

Query: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
             VE  + +     G  EE  + L     L +H + + N+ +  L Q L DG         
Sbjct: 1280 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1329

Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
              ++  +N+  E + S   ++ +E  R + +L+   +   E+   +H +Q   + L F  
Sbjct: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1386

Query: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
            +Q          +  +PQE + ++  L +     +E+   +  K +     +Q+ +  KK
Sbjct: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446

Query: 6872 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6914
            +   +++  L +  + +   L            ++PA++ K  + ++ +    H      
Sbjct: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1506

Query: 6915 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6956
            ++SEV S + ++      ++QK + +N K             N +G K      Q  K  
Sbjct: 1507 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1566

Query: 6957 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6986
            K+    ++             ++   +S ++               + +++E ++     
Sbjct: 1567 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1626

Query: 6987 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
                           +T   ++L  +N +W  +     E + LL    +    ++ NV  
Sbjct: 1627 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686

Query: 7034 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7086
            +  W    +  L +  +           K  Q  ED++K  + E       V+       
Sbjct: 1687 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1735

Query: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7144
             L+ N+ +    +V   + EL   +A + H +  G+  I LK +    S  +   + + +
Sbjct: 1736 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1795

Query: 7145 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7198
                   L E  ++        G+++ +  + DNLQ    D  K+E        I  QLL
Sbjct: 1796 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1850

Query: 7199 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7258
            +  H        N LK++  +      EI+ Q          W +YK  +      +   
Sbjct: 1851 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1892

Query: 7259 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7318
            E +   L +    + I             ++ + L   K+ L  +    E L +     A
Sbjct: 1893 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1937

Query: 7319 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7358
            A A++  Q+ LS+    +E    +            ++ ++     D          T+ 
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997

Query: 7359 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7416
              +  +   ++E E++L   D       DL   +E ++ +K  + + S     +      
Sbjct: 1998 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057

Query: 7417 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
              +     + +K  + L++    W  ++    +R  +    + + + F    + + ++L 
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117

Query: 7474 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7532
            + EQ L   +I  N++H   +    EL Q  +  RQ ++ ++   G+ +++Q    D   
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2176

Query: 7533 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
               KL  L+ +WQ V ++   R+  ++ Q      ++    +   WL E        + S
Sbjct: 2177 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2231

Query: 7593 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7647
            +P+     QQ +   ++V+   +    +QG      E G  +L+SA    E    L+ +L
Sbjct: 2232 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2291

Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7704
             +   +W   S  L E++ ++   +KD  + EK + D  E+L      LS     L  ++
Sbjct: 2292 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2351

Query: 7705 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7762
            +         +E E AV +   D+ +  +L      Y        +  ++E L  +W+  
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2409

Query: 7763 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7784
              L  +L  ++  +   L                     E A+                 
Sbjct: 2410 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2469

Query: 7785 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7838
             F+    EL +WL+ ++  +       GD+  I EMI K K   Q+     ++ + QL++
Sbjct: 2470 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2525

Query: 7839 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7887
            +    + L  K S++   + I  ++ ++ ++W  + + +  R ++L E        L A 
Sbjct: 2526 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2585

Query: 7888 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7947
            ++ ++ +   R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    
Sbjct: 2586 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2637

Query: 7948 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
            +L   LL D  A  T      +   T N++  WR+I     ER   +EET RL Q+F  D
Sbjct: 2638 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2693

Query: 8008 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
              +F  WL  +E TA               S GV     KE +K+++  Q ++       
Sbjct: 2694 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2748

Query: 8057 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
              +++  +++ R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    
Sbjct: 2749 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2808

Query: 8116 ARDSILVWLTEMDLQLT 8132
            +   +LVWL   D +L+
Sbjct: 2809 SLQELLVWLQLKDDELS 2825



 Score =  179 bits (453), Expect = 1e-43
 Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)

Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
            +L E+     +YQ +L+ + + + + E  L    E     E    Q   H+  M ++   
Sbjct: 329  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 388

Query: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
            Q  +  +   L  +L+    +    E+  +Q  + +L  R   +R+ +  K+  L   L 
Sbjct: 389  QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446

Query: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
            D      Q Q L+       EL+ WL  T+         P  P   D++ Q+   + +  
Sbjct: 447  DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 494

Query: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
            ++EQ+ V ++ L+    V +E+      A  +++ + L  +              L+  L
Sbjct: 495  DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 554

Query: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
            L+ QR L ++Q        EKE++   +  T      E L            SSLQ+   
Sbjct: 555  LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 601

Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
            L+ +L ++K  +  + S  +++L        +                  +K+ A  D  
Sbjct: 602  LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 643

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
               W++L Q+       L+    Q  + V  ++P+   + V      V T+++  V    
Sbjct: 644  ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 692

Query: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
                 A EE+       KRQ      + ++L   ++   +W+   E  L        +  
Sbjct: 693  ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 741

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
            E  +F +E    D+KE    +++ K          +  +QA  E   N  V  D++    
Sbjct: 742  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801

Query: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
             +L+   S   + C  + ERL        I+ F N L+ L   T+ A+N ++ +Q     
Sbjct: 802  EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 857

Query: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
                +  Q++  +   + L      I  LK +   L+ +      L        + + ++
Sbjct: 858  EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917

Query: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
               + +R   L    +     +Y+  +  +   ++  + K++       D +I+     E
Sbjct: 918  FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
            +Q L    +E   GL       + + +K  S   +K      E+  +    +S +++   
Sbjct: 978  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037

Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
            K   ++  + +  +H+   ++ ++     ++   P++G    + + L  ++   + L S 
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1093

Query: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
            +   QP L  V + G+++         S LE++L +L   W     ++      L+  L+
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153

Query: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
                 Q + +++  W+  A++  E+  +      P EL+   + +    E +++ +A+  
Sbjct: 1154 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1211

Query: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
            L +   S  + + +   V    L+ EL  + + +  L T +    + L ++         
Sbjct: 1212 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269

Query: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
             + +   W++ +E  + K  +NI    G + I E L   +      N  + + D  NQ  
Sbjct: 1270 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1318

Query: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
            ++I +Q +           E+L   N  W+ L      + +LLE  ++S  E E ++  +
Sbjct: 1319 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1378

Query: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
            +      +K+L     I D+       ++ Q ++  + + E  +E+++++          
Sbjct: 1379 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1436

Query: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
               + + Q K +DVS         L Q  AN +  + + K++L                 
Sbjct: 1437 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1475

Query: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
                 E +  L      +   E VQ Q+++  NL   L + +  ++       Q++++  
Sbjct: 1476 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530

Query: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
                + L   +  + + +N L  ++ E+ Q  +  L+L ++ +   K+     +      
Sbjct: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1587

Query: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
             EL K +  + +    D EVA W +      K +   K  L  + E+GE LK  +     
Sbjct: 1588 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1641

Query: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
              +  D+LSL         +  ++  +L   +L+Y    ETF ++++ +  WI++A+ +L
Sbjct: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1698

Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
                    S+    Q++ + LK    + + + P +D   +    L  N  +  R      
Sbjct: 1699 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1752

Query: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
            +  LN  ++ IS +  T + S     L Q  + ++K    +E  +Q    L  E      
Sbjct: 1753 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1810

Query: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
               +    +E    E+  R   L   I D ++         R+E  +K  LL  +   + 
Sbjct: 1811 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1858

Query: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
                QRR        QW +Y+  A+ L K L ++       L S+P P        DE +
Sbjct: 1859 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1907

Query: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
             KE     Q+    L     +   LS D GA  A++    ++ ++W+    +   Q ++L
Sbjct: 1908 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1965

Query: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
             F          ++   E     I+       T    +SQ+L +  + L+A  +  K+ E
Sbjct: 1966 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2025

Query: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
            +      ++ +  D L Q S   D +     +A  SA  +    L E +  L  QWE++ 
Sbjct: 2026 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2085

Query: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
                 R+ +    + +W  F    K   +WLT+ E  + +     I E  E  K     K
Sbjct: 2086 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2142

Query: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
            + Q+ I   Q     L   GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L
Sbjct: 2143 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202

Query: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
            +E    + +  ++++    WL   ++  + P+  +    ++++ KL + + L  ++    
Sbjct: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2260

Query: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
             G+   LN     VL+    A  +  E D ++   +  + +W  +     E++ +IE   
Sbjct: 2261 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316

Query: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
             +  +L +K  D   +      WL              +   F      I   AK+    
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376

Query: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
                       E    +  +R++ +  ++ + +N+  + L R  + D A  L  +     
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2435

Query: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
            Q    + + V    T+I +      L   +    +F  A   +  WL+ +D  ++   + 
Sbjct: 2436 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495

Query: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
                 D+   I + KA  Q++     ++E++I   + L  K+   +A  II + ++ ++ 
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555

Query: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
               EV   ++   ++L  +     +   +  E E     A + L        ++ + Q  
Sbjct: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615

Query: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
               +  LA+ LR                 +W  + D++ DL   + R   ++D       
Sbjct: 2616 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658

Query: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
             ++    +      +S   +ALE   R L +  LD  +F     + + T N+++  T   
Sbjct: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2718

Query: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
              L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   +
Sbjct: 2719 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2778

Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
              +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   
Sbjct: 2779 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2836

Query: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
            ++ Q    +  ++ +  ++ +I+S       F      E                     
Sbjct: 2837 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2896

Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
            +R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K   
Sbjct: 2897 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2956

Query: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
             P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2957 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998



 Score =  179 bits (453), Expect = 1e-43
 Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)

Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
            RYQ+   +++ WL SA+D L    Q    +  ++E+V+D  +    +  ++ A      +
Sbjct: 339  RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394

Query: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
            +L  G++L+   +L + +   ++ +++ ++S+W  L       Q  LH++ MD       
Sbjct: 395  ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 452

Query: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
            + E+  W++  E   +K E+        + +   +Q++K  + D+  +Q+ V+ +   V+
Sbjct: 453  LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511

Query: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
             +   D  S         EQL  +   W  +     ++  LL+ +L  W           
Sbjct: 512  VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568

Query: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7090
             W   +E  + + H  G  DQ  + ++L+    L+  ++ K++ + K+   +Q+ L+ ++
Sbjct: 569  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 628

Query: 7091 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7121
            NK                              +S  V +T   L QT     +  +  + 
Sbjct: 629  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688

Query: 7122 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
            +IL+K   ++          ++  D     +++  + E    ++R   +  S E A+  +
Sbjct: 689  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 748

Query: 7170 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7218
              N  +L++ +   ER   +KF           ++  Q++ E      +++    +++N 
Sbjct: 749  EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 806

Query: 7219 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7275
            RW    + ++E+L         W  Y++      + +QQ E  T      LK        
Sbjct: 807  RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 858

Query: 7276 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7335
               + + ++ C D +  L  ++  +  L      LK++        + +D ++ + H   
Sbjct: 859  PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 916

Query: 7336 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7393
            +   +  ++  LQ     L    + +++ A+  W+ ++E  L     S  +D   +++R+
Sbjct: 917  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 975

Query: 7394 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7447
             EL+            L  L+    E+  + P  ++ K     + +   W  +SSQ  E 
Sbjct: 976  GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1035

Query: 7448 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7505
              KL+  + + +      +T  +++ + +  L  E    G+ + L +Q +   L  +++ 
Sbjct: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095

Query: 7506 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7565
            + Q  L+S+   GQ++  + + +       +L  L+ QW  + ++   R+  +   + + 
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155

Query: 7566 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7623
               ++   ++ +W+   E  YL        P  LQ+A    +E++  ++   +++    L
Sbjct: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1212

Query: 7624 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7683
              E+   ++  A   A+ AL+ EL  +   ++    RL  + K L  +   W +    + 
Sbjct: 1213 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1272

Query: 7684 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7741
             + + L    FK K ++++P   EE+         LEN +    D+  Q+ +L  TL+  
Sbjct: 1273 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1329

Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
               D++  +NE +E    +W EL H+ ++RRQ++ E+  + A  +EK+  L         
Sbjct: 1330 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1377

Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7856
                     I+E +  + K     IA    +K+   QM +   K      SHE    E++
Sbjct: 1378 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1424

Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7910
             K  +  +  Q +L  I    KKL++  +  +   K       +   +  L  ++  L  
Sbjct: 1425 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1483

Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
             +   S   E +Q +LN    L + + +  + V  V+     ++              + 
Sbjct: 1484 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1538

Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8030
            +    L   +  + A   ER+ ++E+  +L +K   + +   +WL +++      S+   
Sbjct: 1539 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1598

Query: 8031 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8085
            + +    E+   +A Q+++ +    L+ I +    L      +E   +   SL       
Sbjct: 1599 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1652

Query: 8086 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8145
            N  W  +  R    L  L  +    E F+   D I  W+ + D  L   E       +  
Sbjct: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1712

Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
            +K+LKA   +I     K++    Q   L+         ++E ++ EL      +  R++ 
Sbjct: 1713 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1769

Query: 8206 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 8260
                +    L     D    L   E E++    L +  ++ D + D+  + +       +
Sbjct: 1770 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 8319
            L Q +  ER   +       +  +    ++  +DL S    +AL    +  Q     Y R
Sbjct: 1830 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1880

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             A  L      +E ++  L +  D+ +  I++ +  ++ K      +    +G  +  G 
Sbjct: 1881 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1937

Query: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439
              +   +  +L  + +E E     F  L+  +  T  V +   ++  + +  E+    + 
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1995

Query: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499
                 + +++  +   L + E+ L        + D + +  Q + LK ++ ++      I
Sbjct: 1996 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2048

Query: 8500 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 8556
              I+       Q+ +   R  LQ+ LSQ++ +W++V  + ++ +G    ++ + + FH  
Sbjct: 2049 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2108

Query: 8557 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 8615
             ++ +  L   E   R+      I  N +    + + K+L      + + Q  V +L   
Sbjct: 2109 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2161

Query: 8616 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 8674
              +++  +  TD    +EK+  +  R + + K++S   K LE+  ++ S  Q+DL+ +  
Sbjct: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221

Query: 8675 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 8702
              +E D   S+    G+    ++K  + K
Sbjct: 2222 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2250



 Score =  179 bits (453), Expect = 1e-43
 Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)

Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
            H+ ++++L   Q  +G + Q    ++  G   +  EE  + +++  +  R  CL +    
Sbjct: 378  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 436

Query: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
            K +N   V  +L+++++ E     +  W+ +T+E      +E +    +L+ L  +   H
Sbjct: 437  KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 489

Query: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
            +   E + +EQ +   L    ++  E S   A  AL+ +++   D+  +  +  E     
Sbjct: 490  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549

Query: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
             Q++  + Q+L ++       L  K D V +  T       E+     KL  L A ++K 
Sbjct: 550  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608

Query: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
                        + +GKL  L Q  +   +N+ S   +  + L+ +    + +++ +EK 
Sbjct: 609  ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 656

Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
                       S +Q+ +     Q  L +           T  ++ +T+V   E++  + 
Sbjct: 657  -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 694

Query: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
            A+     EEL      + + +   ++  K+ + ++ +L + + +++A L SPE      +
Sbjct: 695  AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749

Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
               S  +  ++ +E  + K +  +  Q A R  + +V  +      A  +++ + +L   
Sbjct: 750  GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807

Query: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
             I+ C ++   +  ++Y+     +  +++ L+Q+   A   ++ +P   S    +++Q+ 
Sbjct: 808  WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 867

Query: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
              ++   ++ G Q QI  L  K + + +K K               +G   LD + +   
Sbjct: 868  ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 911

Query: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
            +    V      R   L      L P+  +       + +       S   ++ TD  + 
Sbjct: 912  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971

Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
             Q +   QAL +   +  +   + ST+  +   +   E S    ++  +++  W+ L + 
Sbjct: 972  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
            + E  + L E + + +K Q+ +Q++   M  +++ L E  P  G S   + Q+ + + L+
Sbjct: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091

Query: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
             +I  +Q  +N +     +++ +E   A+P     L++ L  L  +   +  +   +++ 
Sbjct: 1092 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147

Query: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
            L+  L   +  Q+    +  +  +A+E      +   T   L  A+   K   +   Q  
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207

Query: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6184
                +L E    V+A +   V  E L  E +  T +  + L  +L     +L E+    H
Sbjct: 1208 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1265

Query: 6185 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6243
            +    ++   +   E +  L  T++ PG  E                     E+ + L  
Sbjct: 1266 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1304

Query: 6244 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6303
             ++L+R       +I I    A+T  D G   +++++EL          +    +W  LH
Sbjct: 1305 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1351

Query: 6304 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6353
            +E   +QKLL+  ++  QE        Q   +  ++ L+     K D     Q+   + S
Sbjct: 1352 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1411

Query: 6354 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6405
             L     + EE+   + G +        I + QK    VS          + E+RL  + 
Sbjct: 1412 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1471

Query: 6406 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6448
             +L E        ET    QE+          L K + E+  E++       Q    +  
Sbjct: 1472 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1531

Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6508
            +N   +++ +  L    + L + V +R  Q+++ L+     + ++ VL   LA     + 
Sbjct: 1532 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1591

Query: 6509 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
            ++ A   E   +     +   +   KE +   + LK      +V +     L K + + +
Sbjct: 1592 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1646

Query: 6569 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6611
            + + ++ S      S   + L L  +Y++ ++               AD L    EK   
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706

Query: 6612 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6669
             QK  ++   K E+  +  K         + M       RK++   +       +EL  +
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1759

Query: 6670 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6724
             +A+  R    K  + L+        L++   ++ + LE +E+ I   V L EE  N+D 
Sbjct: 1760 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1812

Query: 6725 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6784
              D     + L    +  Q +   + D+ KR  I I    L+++ N L +       K  
Sbjct: 1813 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869

Query: 6785 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6839
            +  H+       W +Y+ ++ DL+  L   + +L    +     +   + +EL+  ++ L
Sbjct: 1870 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1922

Query: 6840 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
            NA    ++ +    +  +              + S   Q  RL      T+R E   + +
Sbjct: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982

Query: 6887 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
            +   L ++ +P+  + E  H  Q        A+ EV   ++  +   +  ED  K     
Sbjct: 1983 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2034

Query: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
            K I + LQ+  G +IDI   + T      + LQ S+  VE     +    E L  ++  W
Sbjct: 2035 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2081

Query: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 7061
            + +  +  ++    +  +E W  +  +++    W    E+ L+  Q     + A  +  L
Sbjct: 2082 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2141

Query: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
            K   +L+D I  ++  V  +   G  +IQ   +  +SI+   L  L   W  +   +   
Sbjct: 2142 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2198

Query: 7122 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7181
            K  L+   +  S  +   ++   +L EA  +++   L  G  + ++ +++ ++ L ++L 
Sbjct: 2199 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2257

Query: 7182 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7235
             ++  L++       +L      P   + L N LK+ N++W      L E+  E     K
Sbjct: 2258 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2317

Query: 7236 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7287
             L QL ++ +D  +Q        S ++ Q +  N+  +     D+ + E+A   +  D  
Sbjct: 2318 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2376

Query: 7288 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7323
            ++L KG    K+          L +L  + K      Q++ A             AS  Q
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2436

Query: 7324 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7381
            +  L ++Q +   E A+ K +  +SL   V     F ++   L  W+   +++++ Q   
Sbjct: 2437 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495

Query: 7382 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7434
               DL  I E + + K  M       P L+ L      L    +++E +     R++ + 
Sbjct: 2496 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2554

Query: 7435 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7494
              W  +      R  +L   L     +LE  E   + L Q   KL     G Y     Q+
Sbjct: 2555 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2614

Query: 7495 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
            +  E  Q     RQ   +  + +    +LL     DD  + ++    ++  W+ + +R  
Sbjct: 2615 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2674

Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7611
            +R   ++   R  Q++    EK   WL E      +    +    ++ R L D    KE 
Sbjct: 2675 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2730

Query: 7612 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7662
             K +   QG        Y    E  +++L S +   +A  LQ  L  +  KW     +  
Sbjct: 2731 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2790

Query: 7663 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7714
              +  L      W++    + + L  L+    +LS+  P            ++H    R 
Sbjct: 2791 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2850

Query: 7715 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7760
             + +  V   T +  ++ L +  L                  A +++ +L ++ E +  +
Sbjct: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910

Query: 7761 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7817
            WE+L    +  +++I E L       E   EL   L Q E         GD+LI+ + + 
Sbjct: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970

Query: 7818 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
            L+  K  + EIA  +EN   +  +  +L     +     +   L  +N RW+ L   +  
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3029

Query: 7876 RVKKLKE 7882
            RV++L E
Sbjct: 3030 RVRQLHE 3036



 Score =  176 bits (446), Expect = 9e-43
 Identities = 468/2732 (17%), Positives = 1059/2732 (38%), Gaps = 408/2732 (14%)

Query: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
            S E+ +    E+    E + D  +  E   + L  HQ +   I         Q+     G
Sbjct: 353  SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 404

Query: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
             G L +       E++  L S  + L   S E+Q    R+ + L+  +  E N + + + 
Sbjct: 405  TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 463

Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
              +T    E  L    LE L  +++Q K   +  E   V+  +L      V E+S    G
Sbjct: 464  EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 518

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
                  L++Q K + ++   +    E+    ++ +  KW          S W++EKE  +
Sbjct: 519  DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 578

Query: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
            N + T+      +M  S  K+ + + +        LE++ QS  +  +  +      K  
Sbjct: 579  NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 630

Query: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
             + +  E  L   A+C +  +       QK E++  +I Q+V+  +  L          T
Sbjct: 631  SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 673

Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
            +T             +E++++  T      R+ +      +E      Q        K+R
Sbjct: 674  QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 708

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
            Q  +++ +   +RL+ +++   +W+ R EA   SPE  I           + + A++ E 
Sbjct: 709  QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 765

Query: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
              +A  + KL     S  ++  +      +   +K   EQL+ RW +  Q++++R+N+L+
Sbjct: 766  --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 823

Query: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
               +++A   + QQ +++  +   W+K+   +  T SE + +  Q+ +   KD    +  
Sbjct: 824  YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 878

Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
             + +++ L+     L   G+      L          F++    V+ R+  L  + + L 
Sbjct: 879  LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 936

Query: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
              +   ++S I   ++Q  T  +   ++  + +++E+ L +      +L+     L  + 
Sbjct: 937  PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 996

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
            +  +   K   SE     ++  +++ G  +++ + L     + +      +  Q+  + L
Sbjct: 997  TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1056

Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
             K + +++    +E       + L+++L+    L  ++ + +  L  + +  ++I  + +
Sbjct: 1057 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1116

Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
              FA  ++ E+  L   WD   + ++  +    G ++     Q   S + + +  A    
Sbjct: 1117 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176

Query: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
            + R    K  ++L+ A  + + AK +   K+  +   T     ++++   +       +K
Sbjct: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1233

Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
             ++E+    +  +  +L      L    + W ++LS  ++   W N    ++   +   +
Sbjct: 1234 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1289

Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
            N     E + E    ++N     E+  +++  L +   +     +L   E +        
Sbjct: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349

Query: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
                 V +  L + + QS Q  EK ++ I    T +++ L     ++   A      + +
Sbjct: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1404

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            E Q  QS+++S + +L  +  K H+   E+  R ++ +    + +  +  K +   + + 
Sbjct: 1405 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1461

Query: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
              +F + +QE +      K        ++ + +V++++L+   N+  S+S+ +S+++ V 
Sbjct: 1462 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1519

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            + G+ +      +    + E++T     +     +  + KQ L+ C         +   L
Sbjct: 1520 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1579

Query: 2528 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2569
              W+     E+ +R   E +          G++ Q   EK+      + +V   L  +L 
Sbjct: 1580 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639

Query: 2570 ARESL--DKLS------------------------------------------QRGQLLS 2585
             +E+L  DKLS                                          Q   LL 
Sbjct: 1640 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699

Query: 2586 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2639
            E      Q+     + L +  N +R     T+++  +      +H  + +E  +  +   
Sbjct: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1759

Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2685
              AI  R+   ++++  K+ LE+  S IQ  LL   E E++  + +              
Sbjct: 1760 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1817

Query: 2686 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2737
            G  ++ L+  +   QR+   +     ++   ++ +  +A   L S        +  QW  
Sbjct: 1818 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877

Query: 2738 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2791
            Y  + + L + ++ +++K+    +P+   K K +        + L ++  +AE  +    
Sbjct: 1878 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1937

Query: 2792 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
             +  +  ++         +    +  +  F  I TV +E M  + E +   + Y+ + + 
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 1996

Query: 2852 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2905
             T+  H ++     E+L    D+ + D     K+   +K + DS +  + R+  + S   
Sbjct: 1997 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2056

Query: 2906 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
               Q+ T      +   +  L   W++               V++M    Q   G+  + 
Sbjct: 2057 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2098

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3019
             +   +F   +K + Q LT  E      +I E W         +E+ D + + +     L
Sbjct: 2099 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2158

Query: 3020 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3074
             +   E+ + S   D S    K+  L   +  +C Q S   K  + ++ IL + F++   
Sbjct: 2159 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2217

Query: 3075 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3132
            +F  WL  A    +   + P    ++   L++++  + E    Q  L  +   G   L+S
Sbjct: 2218 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2276

Query: 3133 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3185
              ++ E+   ++ K+      W      L +K+  +E        L+ +++D E     +
Sbjct: 2277 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2336

Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
              WLS     +      +Y+ P  +     +Q     +   +P +  +  K Q L++ + 
Sbjct: 2337 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2390

Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3284
            A++  + ++  LSS++ A++ L +E  ++       L  I A   Q              
Sbjct: 2391 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2450

Query: 3285 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
                                F+    EL DW++    ++ S      D   ++   +K +
Sbjct: 2451 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2510

Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3383
            A +   +++  Q++ ++T  +++   TS +   T I  +++ +++ W  +       + Q
Sbjct: 2511 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2570

Query: 3384 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3426
            L   L   ++W   ++   Q  G        W      +D+++  + E+++   +LR   
Sbjct: 2571 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2630

Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
            T +  A  L  ++L   S  +T +V       H +T    +++   +R+I +R  E    
Sbjct: 2631 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2679

Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3523
             E+  RL Q++  DL+ F  WL + +                       E + Q+  L+G
Sbjct: 2680 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2739

Query: 3524 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3583
            +   H     +L E        Q +L S+  + + V+         R L+++   W   +
Sbjct: 2740 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2786

Query: 3584 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS---------PRTRRQS--NRA 3632
             +    R+      ++ + +    Q++  WL+  ++++S         P  ++Q+  +RA
Sbjct: 2787 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA 2846

Query: 3633 TK-EIQLHQ--MKKWHEEVTAYRDE-----VEEVGARAQEILDE---SHVNSRMGCQATQ 3681
             K E++  +  +    E V  +  E     +E++    +E+  E    +V   +  QA +
Sbjct: 2847 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE 2906

Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
            + + ++ L L   +  + ++E ++ L+E + +
Sbjct: 2907 VNTEWEKLNLHSADWQRKIDETLERLQELQEA 2938



 Score =  167 bits (423), Expect = 4e-40
 Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)

Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
            E+  +L  A+  LQ      +++E  + ++     + ++  L + Q  V  I++      
Sbjct: 346  EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 403

Query: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
               KL++ EE+   +++N LN +W       + +QSN   +  +   Q+ ++ +D +   
Sbjct: 404  GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 463

Query: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
            E          +   + + E     LE LK+    +Q+ K   EDL+   Q+ +   +L 
Sbjct: 464  E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 507

Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
               +V +++S  +     LE              E+L V+  R+  +  W E++      
Sbjct: 508  HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 548

Query: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
                         LL D L     L  +Q L  + + + +  +  +     +   + LS 
Sbjct: 549  -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595

Query: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
             Q      +DL  ++++ + K  S K Q L++  +  S  Q+ E  +   ++     D+ 
Sbjct: 596  LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 650

Query: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
            V K  K+      ++ T Q  +T       E +  VT +E+  V    +EL         
Sbjct: 651  VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 701

Query: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
                + +++  +   RK    D  +   W+ +++ ++  PE  +  +         K   
Sbjct: 702  PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 761

Query: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
            I  +  E    L    R+ Q ++  +     N       SE+LN+   +F  +++   + 
Sbjct: 762  IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 821

Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
                   I    +   L ++TT + + L+ Q    S+ PT  A++  L +   C+  ++ 
Sbjct: 822  LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 875

Query: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
            ++GL   ++ L  +    +  GQ P   D      T + +      +  E+ +  + DT 
Sbjct: 876  LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935

Query: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
               +  E M       QQ E +L      Q  V +  +  E++L    +L  SLQ+    
Sbjct: 936  PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 991

Query: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
            L  ++  +++++         K + + +  +G  K L+S + E   + E +M +    Q 
Sbjct: 992  LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051

Query: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
             +     W+  V   L        + + +++++++ ++   ++Q+    +N+++   ++ 
Sbjct: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111

Query: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
              +A+   ++ LE  L EL+     + + +  R+  L     +     +     ++W+  
Sbjct: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171

Query: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
            A+E  +      + ++ +E  K+  E    +++      ++  L  +++ +I    P  +
Sbjct: 1172 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229

Query: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
            E L++++ +L    Q +      +   L+   A WH+     E+  + +N+ E     F 
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1284

Query: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
            L  T +     E++SE      V++S    +   E+  +Q+       T        ++ 
Sbjct: 1285 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1338

Query: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
             + T   RW  L   A  ++K+LE ++         +    E +  +  +L    A+K  
Sbjct: 1339 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1398

Query: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
             A++              ++ Q     L    +S L++      G+E    Q + +  D 
Sbjct: 1399 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1442

Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5355
                 + V    +L ++        E ++   K  + E K +L  P +E        + +
Sbjct: 1443 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1496

Query: 5356 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5415
            QL     L    +  +  +E + +  ++      T  P EL  ++  + L     +++  
Sbjct: 1497 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1553

Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5471
            K+ E +Q      +LSR+++K       +LT+  A TD  +  ++  + +   LD     
Sbjct: 1554 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1609

Query: 5472 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5521
                 K +E      K + + G+     LGK       KL+ L+   I    +AE  L+ 
Sbjct: 1610 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1669

Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
            L +   H+E +++ ++ I KWI +A  L   +       Q +E  +  + L  E  +I  
Sbjct: 1670 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1725

Query: 5582 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
            ++++  ++   L +    +C + +  Q++EL      +   IK    ++    K++++F 
Sbjct: 1726 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1783

Query: 5639 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5689
            ++++KL   LE   Q    L   +  +   ++     + LL   ++L+ ++      + +
Sbjct: 1784 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1843

Query: 5690 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5749
            ++ Q  L+   + +  L       + +++A  + H   Q        +   +  E+++  
Sbjct: 1844 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1898

Query: 5750 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5802
            L     ++ I+   RE++ K    + ++  QA+    +  A  ++  Q Q++      + 
Sbjct: 1899 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1957

Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5862
            K    +  +   + TV E E +   TED+  E+   PS + + +        T +S    
Sbjct: 1958 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2008

Query: 5863 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5922
            E         +++P  C              ++I      S+ R+      IH   +A+ 
Sbjct: 2009 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2059

Query: 5923 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5982
            +   P         L  L   WE +  +  ++Q     ++E+ +++   ++  +  +   
Sbjct: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2119

Query: 5983 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 6036
            E  L ++  P      +  EH      +  LQD I + Q      ++  EE++ +S + D
Sbjct: 2120 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2173

Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
             +    LQ  L  L  R   +  + S +++ LEE          Q+  L  ++ + +E  
Sbjct: 2174 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2220

Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
             WL          L P KE   ++ +L   + ++ E+  +   L +L+     +L+    
Sbjct: 2221 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2279

Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6214
             + +E ++L  KL++     +++ RAL +KQ  ++   ++  + E  ++    Q   +  
Sbjct: 2280 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2338

Query: 6215 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
            WL+  R     + Q  Q      +E E  +  ++  +  + S+G+ +             
Sbjct: 2339 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2386

Query: 6272 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6331
             EKP               A   ++ K E L  E+    +LLQ +  ++ +         
Sbjct: 2387 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2422

Query: 6332 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
            L  G+    G  PTQ  + VT  +     A  ++   S      S+ LE       +   
Sbjct: 2423 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2475

Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
            T L D    L           +  + +Q ++  D+++++E + K K              
Sbjct: 2476 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2515

Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6511
                                + QR  Q++E +    N +N      TS  + + II    
Sbjct: 2516 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2546

Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6571
                     ++IE IQ   D ++E              LQ  +  + E+ K         
Sbjct: 2547 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2576

Query: 6572 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6629
                       Q L  K + E+ L      LE+ +E   G   +    K+  E +QL   
Sbjct: 2577 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2625

Query: 6630 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6689
             +++   ++    L   L R   +   +K       + A   ++ KR  +R   LE   E
Sbjct: 2626 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2682

Query: 6690 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6740
            T   L +   +L + L  +  +  +  ++++   ++RL+       + +  +Q L+  + 
Sbjct: 2683 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2742

Query: 6741 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
             +    + + ++ +++L S+  SD    L+ +L+ +   W     K       LE     
Sbjct: 2743 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2802

Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
            W R      +L+ WLQ   D L     +   +  +   V+   +    F +E+  +  + 
Sbjct: 2803 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2858

Query: 6857 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6895
             S L T    L  + ++                     T  LR +   ++++W  L  + 
Sbjct: 2859 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2918

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               Q K+ +  +++L      ++ +  + L +  + K        +   ++ ++L+K K 
Sbjct: 2919 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2976

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
             + +I   +  V  VN    Q+++  ++    + +   +    +N  W++LQ  V ++++
Sbjct: 2977 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3032

Query: 7016 LL 7017
             L
Sbjct: 3033 QL 3034



 Score =  162 bits (409), Expect = 2e-38
 Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)

Query: 600  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 652
            E +S  S L E   N DRY   +  + +WL  AE  L       N  E  K  F  +  +
Sbjct: 322  EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 381

Query: 653  WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 701
             +         GN L             E    ++++Q+ LLN RW   R   ME +   
Sbjct: 382  MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 441

Query: 702  QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 754
                MD   ++  +    L+       K   EPL     ++K  +Q       DLE  + 
Sbjct: 442  HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 501

Query: 755  RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 797
            RV  +     ++ +++      + +E+ K   + +A + +  E              +LT
Sbjct: 502  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561

Query: 798  KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
            + +  +S  L E +  +  +     K       SL K+  +   LE++ QS        Q
Sbjct: 562  EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 621

Query: 857  ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 899
            +LL+  +N   T                 +  +EK +  + + VT +       QT +  
Sbjct: 622  DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 679

Query: 900  QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
             +  +    Q +VK   +         K+ +  +S + K+ +    EL   +  ++  L+
Sbjct: 680  TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 739

Query: 952  EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 995
                PE  + R    FS L ++V NA           L+        L EQ         
Sbjct: 740  S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 795

Query: 996  GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1052
             +++A  +L+ +W +   L  E    L +    +     L  +E+  T  +   K+ P  
Sbjct: 796  SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 855

Query: 1053 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1111
             SE   IK       D+        RL  ++    +L ++       G   + L     A
Sbjct: 856  PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 909

Query: 1112 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
              + ++++  D    +              Y    S   +W+  +ET+L   +    D  
Sbjct: 910  FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969

Query: 1159 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1218
               +    ++ +++ + ++   L +L + +K +++ +    ++K   E  ++   +K L 
Sbjct: 970  IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029

Query: 1219 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1271
            + L E    +E+ ++       + + +K  + E+      ++E+   + D+E L    + 
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1086

Query: 1272 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1331
             +LL+   Q  +       +  Q+I    + E     R   EL++L +  D + +    +
Sbjct: 1087 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1144

Query: 1332 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1391
            +  ++  L K    + +   +  ++ Q   + E +L          EL++  E  KR + 
Sbjct: 1145 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1201

Query: 1392 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
             A Q E  VK  +E          P  ++ L+++ +++    + L   L    KT+E V 
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261

Query: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1505
              W    S  E  + W+ E E +L   E      +    +I   +  +E+ +        
Sbjct: 1262 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1317

Query: 1506 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
            + +  AQ +T G      I  +L        EL E A   +  +   +   Q+ E++L  
Sbjct: 1318 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377

Query: 1564 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1606
            IQ+S++  + +LA  I              KI S  T    + + +++H    +A + + 
Sbjct: 1378 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1437

Query: 1607 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1663
            S I       + V  +    Q+ A  +Q+ ++   IL   K    ALE      + ++ +
Sbjct: 1438 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1497

Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
            L+  +   +      S  EM I   R       Q++Q  Q E   +              
Sbjct: 1498 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1538

Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
                  + V  +KLH  +L  +  +  Q + K +   + +  E     E       W+  
Sbjct: 1539 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1585

Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
               EL   S +  M   +         A  ++ + E++  + HL  +  +G A  L  + 
Sbjct: 1586 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1638

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1901
            GK E    L E+   ++    +A+ S   E+L         +    Q V+  T  + + +
Sbjct: 1639 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1695

Query: 1902 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1961
            + L E +     Q    L+     L+ I  K        + +Q  +  A     C     
Sbjct: 1696 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1745

Query: 1962 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2019
             + L+  + SE +   A +    +  K  + LK +E     +D ++L EP    +QQ + 
Sbjct: 1746 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1802

Query: 2020 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2073
            +    FN  +D    +E  +  L  +   + Q+  D     E+  +   L+   +  K L
Sbjct: 1803 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
              + + +   +     +Y+     + K L++    + +    +D+  +K    + +  K 
Sbjct: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1920

Query: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2177
            ++N  ++  +  +  G  +  E  +I  S                +F+ + T  E T+  
Sbjct: 1921 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1978

Query: 2178 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2236
             + ++E +   +  +    L+    V     E+E   N   P +     + ++  + EE 
Sbjct: 1979 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2033

Query: 2237 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2296
            LK  +  ++  + R++ +HSK    K       TP +   ++  L Q     +++ ++ K
Sbjct: 2034 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089

Query: 2297 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2350
                 F     +  +F  DI     W T+ E+ L      E  E  K    +K++Q  + 
Sbjct: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2149

Query: 2351 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2408
             +Q+ + +       + ++    +   L   +  L ++  E   QL   K +   Q+++ 
Sbjct: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209

Query: 2409 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2468
              F   + EF  W   A   A    +  G  + L+ KL  ++ +++ +   Q  L  + +
Sbjct: 2210 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2268

Query: 2469 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
             G  +   A +S +    ++ ++ + N        Q +K  +AL +   E+ +       
Sbjct: 2269 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2314

Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
                          ++LG+ ++ + + + +++ + ++L  +    E  ++ +Q G    +
Sbjct: 2315 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2362

Query: 2587 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
            E   A Q  +    ++L+  Q+L +    T+   R  +    E +A+   LQ +    +A
Sbjct: 2363 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2418

Query: 2643 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2700
             Q  LA   +T+G+  T  + ++ +   ++ K     KL M  ++     AL   N+   
Sbjct: 2419 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2476

Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
             +           W  ++   + +Q  +   +   N+ + ++    Q +E          
Sbjct: 2477 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2517

Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
            Q +P L+E      +L++  S  E  T    R+                     E ++ Q
Sbjct: 2518 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2556

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            ++++    + + +++ E++KD   +L+A  E    L  A+ +L  W +      A QKK+
Sbjct: 2557 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2616

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
            ++ K+L        + +     LA ++ ++ +A     +H   + + A W+     V + 
Sbjct: 2617 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2676

Query: 2941 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 2997
            ++ LE    L+ Q  L  ++F   +A L +A E  + +L+   ++  LLE     +E+++
Sbjct: 2677 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2732

Query: 2998 CWHKGQEILDA 3008
             W   Q  ++A
Sbjct: 2733 QWQDLQGEIEA 2743



 Score =  159 bits (402), Expect = 1e-37
 Identities = 533/2914 (18%), Positives = 1109/2914 (38%), Gaps = 456/2914 (15%)

Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
            + ++   R++ A  +   WL++A+ T     +I  ++  V       + ++ +    Q +
Sbjct: 332  ESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGR 391

Query: 3121 LNMMLSKGELL--STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
            +  +L  G  L  +  L++++   +Q ++      W+       +K+S L  + + +++ 
Sbjct: 392  VGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQ 451

Query: 3179 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3236
            ++  + + DWL+KTE+   +        DL   +R+ Q+ + + E++   + ++N L   
Sbjct: 452  KL--KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509

Query: 3237 AQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEK-------VSRLDRIVAEHNQFSL 3287
               + E  G  A+ +   ++  L  ++  +   T+++       + +  R+  E   FS 
Sbjct: 510  VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 569

Query: 3288 GIKELQDWMT--------DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE--KEIQM 3337
             + E +D +         D   ML S       K+ L+ +   +  L S+KQ+    ++ 
Sbjct: 570  WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629

Query: 3338 KMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA--GIRCKSQLEGALSKWTSYQ 3395
            K +  + E+ L N +      +Q+  +S   +  ++ +    +   + +E   +  T  Q
Sbjct: 630  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 689

Query: 3396 DGVRQFSGWMDSMEANLNESERQHAELRDKT----TMLGKAKLLNEEVL----------- 3440
              V+     +              +E+R +     T L      +E VL           
Sbjct: 690  ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749

Query: 3441 -SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQER-------AKEAVTKSEKLVR 3492
             ++S L E +        E +    +LQD     +A+ E+       A      SE+L  
Sbjct: 750  GNFSDLKEKVNAIEREKAEKF---RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS 806

Query: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
               E+ + L     WL  +   +  Y+ L+       TT  +  ++Q         + S 
Sbjct: 807  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQ-QLEQMTTTAENWLKIQPTTPSEPTAIKSQ 865

Query: 3553 LHTREDVIP--SGI-PQAEDRALESL-----------------------RQDWQAYQHRL 3586
            L   +D +   SG+ PQ E   ++S+                       +Q +   Q R 
Sbjct: 866  LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQARE 925

Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
             E +T F+ +   +R  E     +  W++ +E K+S      ++    E +L +++    
Sbjct: 926  KELQTIFDTLP-PMRYQET-MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 983

Query: 3647 EVTAYRDEVEEVGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3704
             +   +  +  +    +E+  +  S ++ +   +  ++  R++ L  Q++E  + LEE++
Sbjct: 984  SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1043

Query: 3705 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
              L + ++ + +   W        K     +   D+ ++ K+LK   +L+ D++     L
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG--DSEILKKQLKQCRLLVSDIQTIQPSL 1101

Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV--RKEHMT--LEKGLHLAKE 3820
             S  E G++     E   A RL  E+ +   Q   +   V  RKE +   LEK + L K+
Sbjct: 1102 NSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKD 1161

Query: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
             S+  + +TQ   EY E     + P     E +  + + K  ++     E  VK + E  
Sbjct: 1162 LSEMHEWMTQAEEEYLERDFEYKTPD----ELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1217

Query: 3881 EALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW 3937
             +++     V    LK +++ L ++YQ LC+       +LE       +  S L++  KW
Sbjct: 1218 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1277

Query: 3938 LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI-GQCAD 3996
            L ++  +L   + +   + E I++ L   + +M      ED  N +++   TL  G   D
Sbjct: 1278 LNEVEFKLKTTENIPGGA-EEISEVLDSLENLMRHS---EDNPNQIRILAQTLTDGGVMD 1333

Query: 3997 HL----------------------QAKLKQNVHAHLQGTKD----------------SYS 4018
             L                      Q  L+Q++ +  +  K                 +Y 
Sbjct: 1334 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1393

Query: 4019 AICSTAQRMYQSLE-------------HELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-- 4063
            A    A +M Q  +              E++KH   ++  Q+  + +   Q  L+     
Sbjct: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453

Query: 4064 ----QPPLSRAEAIKQVK--------HFRAL------QEQARTYLDLLCSMCDLSNASVK 4105
                Q P +  + +++ K        H  AL      QE  ++ L+  C     S + VK
Sbjct: 1454 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH-CVNLYKSLSEVK 1512

Query: 4106 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RH 4160
            +  + + +T + I QK  Q +N  +  E +  LK   +EL   + +  QQL+   +  R 
Sbjct: 1513 SEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571

Query: 4161 SELELNIAQNMV----------SQVKDFVKKLQSKQA-----------------SVNTII 4193
               E+N+    +          S V+     L S+ A                 S+  + 
Sbjct: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1631

Query: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVE 4250
            E +  +  K+E+    +++ LN  W+ +  ++    NL L+ ++ ++      D      
Sbjct: 1632 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD------ 1685

Query: 4251 VFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
              + K+  + D L   S+ +      + LK+L   L + +  ++  +DQ   ++ +    
Sbjct: 1686 -HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744

Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIA 4368
             ++LV+ Q S L  R+  +   IK  K  + +  LE+ N    +  E +E   +Q  N+ 
Sbjct: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1804

Query: 4369 EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALS 4428
            E        D  +++  D+     EL  +   L+  I D           +R+ I+    
Sbjct: 1805 EE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQ 1848

Query: 4429 DAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD 4488
              Q+  N L DL  QRRK   KAL    Q+     QA   ++  +      + +  LP+ 
Sbjct: 1849 LLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEP 1902

Query: 4489 -----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
                 + +  +  +  +  L   + +  GL   G  +  E T+ + S+   +++   + +
Sbjct: 1903 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 1962

Query: 4544 DSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLM 4592
              +     H ++E           LE + V   +  E    +   L+   ++  P++   
Sbjct: 1963 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CA 2021

Query: 4593 NESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQF 4652
             +  +L  Q    +NI +   +    +  +       L S   V+   L E L+ L  Q+
Sbjct: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQW 2081

Query: 4653 NVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE---- 4708
              +  + KD+  +   ++   + +   I++  Q L+E E QFLR +++P +    +    
Sbjct: 2082 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWY 2140

Query: 4709 ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ 4768
               LQDG       V  L    +E+ Q+      T      +K+  L   +  + +Q   
Sbjct: 2141 LKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSD 2197

Query: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4828
            R   LE+  +   E ++   +    L+         N  ++P E          G  Q  
Sbjct: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQL 2242

Query: 4829 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4888
               L++V + +E+L     PL  +    Q+    G + +      E   + E+++ Q+  
Sbjct: 2243 KEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2296

Query: 4889 FQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK 4947
               ++SR+L   +  ++A++     L+  L+D++E++  + +    +++ L I N  +  
Sbjct: 2297 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ- 2355

Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQA 5004
                                    E   D+QE   A++ +Q  + EI S+ Q  Y+    
Sbjct: 2356 ------------------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--- 2388

Query: 5005 ANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
                                 + A + +K  +E  S+E    +  L+EL +    L P +
Sbjct: 2389 ---------------------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2427

Query: 5064 KPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
               G    +      Q V + E    ++   S   +++         D+ +A  E+ + +
Sbjct: 2428 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWL 2482

Query: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDA 5176
            +  ++ +    ++      +  E + + KA +  +     ++  L   A  L+ KT N  
Sbjct: 2483 SLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 2541

Query: 5177 SKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5236
            ++  ++  +  +  +W  ++   Q++ + L + + + T +    ++A +++ Q + KL  
Sbjct: 2542 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 2601

Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
                  +   +   +        +L Q Q+ + +     L +L+D +A    ++   +  
Sbjct: 2602 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHM 2657

Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
            IT          E +  + + + + + +RE            ++ET   L     +    
Sbjct: 2658 IT----------ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLD 2693

Query: 5357 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQD 5415
            LE+    LTEA      ++    +++                 L E +  +K +  Q QD
Sbjct: 2694 LEKFLAWLTEAETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQD 2736

Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSK 5475
               E+E        L    QK+ + L               +   D  +L   LD  N K
Sbjct: 2737 LQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFK 2781

Query: 5476 LMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5532
              EL      ++  LE +    K L   + +L  +  Q      +R + +      +++ 
Sbjct: 2782 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQ 2840

Query: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKL 5590
            N++     + ++  + +   T+         +     + L +E +E+  E  A  +T  L
Sbjct: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2900

Query: 5591 QYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK--- 5643
            +       T  EK++   A+  R+ +E  +    RLQ LQ+A    D+K  +AE+ K   
Sbjct: 2901 RKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSW 2956

Query: 5644 ----------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
                      LQ  LE+ +A       G ++ LKE +SH   L  ++ +L      +QL 
Sbjct: 2957 QPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLS 3006

Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
               L   ED+     L   A+   E+  R  H A
Sbjct: 3007 PYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3037



 Score =  157 bits (397), Expect = 4e-37
 Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)

Query: 5520 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5577
            S L ++  +L+ Y   LE +L W+  A+  + A G I+ N    +++Q+  H+  +    
Sbjct: 328  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 383

Query: 5578 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5636
            ++ +    +   LQ  + +  T K+S+       E +E   ++  R + L+ A+ + +  
Sbjct: 384  DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 440

Query: 5637 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5695
                L  LQ   L++    LT  E     ++E+      L  ++E LK +VQ  ++ Q  
Sbjct: 441  LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 495

Query: 5696 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5755
            L   ++ V    L H  + + E +      A+                E+++K L     
Sbjct: 496  LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 537

Query: 5756 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5802
               R  ED+ V   +I    Q L        A +S  E+   KI   G+++Q   L+S  
Sbjct: 538  NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 597

Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5856
            K+  +KA       ++ ++  L +       +LL T   + SV   T        RC   
Sbjct: 598  KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 649

Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
            L    E+S      ++IS       PS    T       +   + +  +  Q +     P
Sbjct: 650  LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 703

Query: 5917 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5976
                 Q   +  +       + +L  SW T    + +     +    ++  + D    + 
Sbjct: 704  PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 756

Query: 5977 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 6036
             K+ AIE + +E                    +   LQD     Q+ L E++V+E   AD
Sbjct: 757  EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 795

Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
              +Q + Q            +  +     QLL E+LN  LE Q    A      +  +L+
Sbjct: 796  SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 839

Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
                + +  L    + P EP  +++QL  C++ +  +      +  L + +  L  +G+ 
Sbjct: 840  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 899

Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6216
                +A+ +A                 H KQ+     A+EKE   +    T  P   +  
Sbjct: 900  PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 943

Query: 6217 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6264
              A  TW QQ ++ L          + +EQ L E ++L  S+  +   +      ++  +
Sbjct: 944  MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1003

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6295
             +   +   K     +E+    +K S+         E+QM                    
Sbjct: 1004 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1063

Query: 6296 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
                + +W +L      K++L Q  L     Q +    N +  G    K +   +  S +
Sbjct: 1064 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1123

Query: 6352 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6406
             + L  LN  ++ +  Q    K   +  +     L   +S    W+   EE         
Sbjct: 1124 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1183

Query: 6407 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6462
              P+E +  +   +   ++ ++   ++    +   ++ +QA P     ++ ++  L  L 
Sbjct: 1184 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1240

Query: 6463 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6506
                 L + +N +C          H++   L++   + N+++    +       A+    
Sbjct: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300

Query: 6507 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6564
            +L  L N+    +    QI  + Q        D G+++           +   +EL    
Sbjct: 1301 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1344

Query: 6565 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6624
              + EL      R+  L Q++    + E++L  + + L    +++A      ++ K +  
Sbjct: 1345 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1400

Query: 6625 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6684
            Q+  + ++    L SH I  E + +        +  +    +++Q     K+     ++ 
Sbjct: 1401 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1454

Query: 6685 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6744
              + +  ++ ++  QE    L+ V+  +P++      ++ +  ++    +L  SL+E + 
Sbjct: 1455 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513

Query: 6745 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6801
            ++  V+  G++++         +L+ ++  L   +     K+++   +LE  LK   + +
Sbjct: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573

Query: 6802 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6857
             E   L  WL +        T   +T    +E +  +L++ + + K    E++ Q     
Sbjct: 1574 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1625

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
            S+   G  L  +       +  +LS ++S W  + +        L + Q         + 
Sbjct: 1626 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1685

Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6977
             +  WI   + ++ + E         K   +     K  K ++N  +  VD        +
Sbjct: 1686 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1737

Query: 6978 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 7036
             +   +  R        Q+  +N  +  +   + T K  +    L+   ++ +++Q L  
Sbjct: 1738 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1791

Query: 7037 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7087
              E +        E+   +     ++ +V+  L+   +L+  I  + K  E KI+Q  L 
Sbjct: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851

Query: 7088 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7142
               N  +D+ S       E+   W         L   L  +  + +S     D+     I
Sbjct: 1852 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1911

Query: 7143 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7197
            +  L + +  L+  R     L     A+ V+   +Q     L K+ R ++ KF       
Sbjct: 1912 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1966

Query: 7198 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
              + H    ET+    +++ +  + +    + E    S+ALL++ Q              
Sbjct: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2015

Query: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
                              A D  A   +D     + L  +KDSL       + +  +  A
Sbjct: 2016 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057

Query: 7317 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  SA   +++ L + L  L+    K       +Q      V  +  F   ++    W+ 
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7427
            EAE+ L+      + + +  +  ++EL+  + +  ++   L+   E +  +    D  I 
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2177

Query: 7428 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
             +++ +LN  W  +  Q ++R  +L+   + L + Q  L +   W+E   + +   ++ +
Sbjct: 2178 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2234

Query: 7484 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7540
              G  Q L E+    +L   E+  RQ IL  +   G  +L    +  +++D+   KL   
Sbjct: 2235 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
            + QW  V R   +++G I++QI+   +  +  E L + L  +          + I  Q  
Sbjct: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2354

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7660
            +    +VQ  E     +Q      +  G+ L    +  A   ++ +L ++  +WK+ +  
Sbjct: 2355 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2412

Query: 7661 LEEQKKKLAFL--------------------------------------------LKDWE 7676
            L+E + K   L                                            L D+ 
Sbjct: 2413 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2472

Query: 7677 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
            +    + D L  L    K    +   L D +E +  ++   ++LE       + +T    
Sbjct: 2473 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2532

Query: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
            LK+  S   + +  +I+ +R+E +Q QW+E+   L  RRQQ+ E L +   + E  +E  
Sbjct: 2533 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2589

Query: 7794 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7849
            + L Q  +K+   + G   ++ + +K+   K   +++   Q N      +  +L +    
Sbjct: 2590 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2649

Query: 7850 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7909
                ++      +N  W+ +   ++ R   L+ET   +QQ   ++     WL   E+E  
Sbjct: 2650 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2707

Query: 7910 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7962
              ++ D+   E        ++  + + Q+LQ +IE H+    ++    + +L   +  + 
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2766

Query: 7963 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 8022
            DA    +Q+   N++ +W  +   S+  R  +E +   W++          WL+  +   
Sbjct: 2767 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2824

Query: 8023 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 8063
            +  +  G  +   +++     AF+R++                    + L  LE + ++ 
Sbjct: 2825 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2884

Query: 8064 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8122
            R L  E R  +    L++   E N  W+ L        R++   + + +E + A D    
Sbjct: 2885 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2940

Query: 8123 WLTEMDLQLTNIE 8135
               E+DL+L   E
Sbjct: 2941 ---ELDLKLRQAE 2950



 Score =  142 bits (359), Expect = 1e-32
 Identities = 456/2427 (18%), Positives = 928/2427 (38%), Gaps = 370/2427 (15%)

Query: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
            + TKE   QLH    + +++T +     E   +        ++  +     +    S + 
Sbjct: 255  KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 314

Query: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
            +  L+  E   F    +E E+ +L+  +++L     W  S     +      + V+ V  
Sbjct: 315  SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 372

Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
              +  T E  + D+      + +  + G + +   +  E E    E+ + M  L      
Sbjct: 373  -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 429

Query: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
            +R   M  +  LH  L    + K K L  W+ + +E     EE  +  +L + K Q+ ++
Sbjct: 430  LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 489

Query: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
            K LQ+ +   +  V S+            +   A LE                      L
Sbjct: 490  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549

Query: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
            +QD+ LK  ++ + Q  +    S  ++ V  +     KD  +  S LQ       ++EK 
Sbjct: 550  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608

Query: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
              Q  G+L +   DLL T   +++TQ+    +A ++  A   D L     K    I Q  
Sbjct: 609  KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 665

Query: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
               Q  L Q          ++ + + +  Q + +  + EL        RQ T+       
Sbjct: 666  TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719

Query: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
                  +  +W++  +  L+ SP+  + R E           AI++ K   FR LQ+ +R
Sbjct: 720  LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 778

Query: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
            +   L+  M +         A  I+Q  + +  + ++   L      W E ++     + 
Sbjct: 779  SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 833

Query: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
             LQ  +Q     +     +  +  E    ++ +   KD V +L   Q  +  +  +   L
Sbjct: 834  QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 893

Query: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
             +K + P   +       NH    + D+  Q+    LQ   D      Y + M+ +  ++
Sbjct: 894  KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 951

Query: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
            ++  T+     L+ +D E     L  L+ L  +LQE++  +  L    ++M +    +  
Sbjct: 952  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011

Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
               + +   +E RW +L   +    Q     + +L  +Q+  Q L +W  E    + E  
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071

Query: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
                  ++ +  L     + S+++  Q  L S+ +   ++  +        ++  L +  
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131

Query: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
            +  + +   V  R++ L   L +       + +    + Q E + + R+     PD++ K
Sbjct: 1132 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1191

Query: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
             V+  K A       +A +K     V  + AQ   + +E  ++E       L+ L + Y 
Sbjct: 1192 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1244

Query: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
             +  + + + + LE+            +KA  WL + +       N+   + E+   L  
Sbjct: 1245 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1304

Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
             +N++  S +  N +  L +T           D   + E +N     FN        ++ 
Sbjct: 1305 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1348

Query: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
            ++ E  + R++   L+E + QS  E E              ++E+L+  D   A     A
Sbjct: 1349 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1391

Query: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
             + + VD     +E      Q  Q D   H ++L                      ++H 
Sbjct: 1392 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1427

Query: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
            +  +  +R L  +   Q K+ + ++    K +++   A     LQ+S ++L  V +HL  
Sbjct: 1428 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1481

Query: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
              P L+  + E  +  +QS       L  ++ E  +E E       ++VQ    QTE  +
Sbjct: 1482 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1535

Query: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
             LD   RV A       L L+  ++     K+   +++++  L++   +    KE     
Sbjct: 1536 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1580

Query: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
            + L + D+E  L + S ++G   ++   +   +AT  EI  Q    +   +V +A    L
Sbjct: 1581 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1638

Query: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
               + L++     L  N + V S AEE L   +E+    + F  N++ +   +   D L+
Sbjct: 1639 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1698

Query: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
                  KP  KED+ +++ + EL   R   DS    D      A   D+ +K  E  I  
Sbjct: 1699 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1755

Query: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
            +N     +S    +KT  +     E E+  S+ + L+  + +  ++ V L+E+     K 
Sbjct: 1756 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1811

Query: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILE------------------DA 5209
             N+ ++ T+   +     + QR T  R R   + ++++L+                  + 
Sbjct: 1812 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1871

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
              +W  +  +     + +D ++ KL  S  E   + ++  +         EL++++  L 
Sbjct: 1872 SHQWYQYKRQADDLLKCLDDIEKKL-ASLPEPRDERKIKEIDR-------ELQKKKEELN 1923

Query: 5270 MLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQE 5321
             +R+Q   + +DGAA    PT  +     +EI +   Q R LN  +   V+    +V  E
Sbjct: 1924 AVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE 1983

Query: 5322 LKDREM------VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQ 5372
                E+        T+I  V   + E ++ L  P +   + +   ++ + L     + +Q
Sbjct: 1984 DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQ 2043

Query: 5373 NIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQ 5428
            +  ++     +K   L +  P E + LQ A   LD    K+    +D+    ++S    +
Sbjct: 2044 SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2103

Query: 5429 ELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAA 5482
                 I K+     T   +   KT   +N   AK  +  L E  DG   +   +  L+A 
Sbjct: 2104 RFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNAT 2161

Query: 5483 VQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 5541
             ++ ++Q+ +     L +K+G L    Q+  +Q  +R  +L +  + L E+   L   + 
Sbjct: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221

Query: 5542 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSV 5596
            W+E+A  +A   +      QL+E+    + L+EE       L+ + E      +    S 
Sbjct: 2222 WLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISP 2281

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE------- 5649
               +K+  ++ +   +  ++ + +  +   ++   KD+ + E +L+ L+  L        
Sbjct: 2282 EEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2341

Query: 5650 ------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MES 5681
                                Q T  + +  +  ++E LS  QHL  E          +E 
Sbjct: 2342 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2401

Query: 5682 LKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAA 5736
            L  + +AV      LR  + D+   L    A+    + L  +    + TAI +  +  + 
Sbjct: 2402 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSL 2461

Query: 5737 VVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 5793
            +++      + +    L   +    + I+ + V   +++++   I + +   Q ++  + 
Sbjct: 2462 MLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP 2521

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTE 5820
            Q+  L +  + L  K  +      +T+
Sbjct: 2522 QLEELITAAQNLKNKTSNQEARTIITD 2548



 Score =  134 bits (337), Expect = 4e-30
 Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)

Query: 7330 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7389
            SQHL A E       +SL    ++ + +  +LE + +W++ AE+ LQ Q    S+D+  +
Sbjct: 315  SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 371

Query: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7441
            +++    +G M+  ++    +  + +LG +L    K       E++   NL N  W  + 
Sbjct: 372  KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 431

Query: 7442 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7499
              + E+ S L   L+  Q   L++   W+    +  +K+  E  G + + L  Q + H++
Sbjct: 432  VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491

Query: 7500 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
             Q ++   Q     + H +++  +   +       ++    L +L ++W  + R  + R 
Sbjct: 492  LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 547

Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
             ++   + +WQR  E       WL E                       D V        
Sbjct: 548  VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 586

Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
            + Q   + +++  K  +L AD   +     +L  +++   S +++ +   +K    L ++
Sbjct: 587  KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 643

Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
             +C   +   LEK                           ++  AV +    LTQ +++ 
Sbjct: 644  ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 678

Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
            +T++   + + I        L++   EEL      +++QI        V SE  K L   
Sbjct: 679  ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 723

Query: 7796 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 7847
            +T++ S ++++  +L        +K     D +E++ AI +E   K +  Q   R A+A 
Sbjct: 724  ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 783

Query: 7848 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 7895
             E   +E      I+    ++N RW     L++ R+  L+    ++A    +QQL++  +
Sbjct: 784  VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843

Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
            +   WL    +  ++P    S   +  + ++N    LQ  IE+        L +  + L 
Sbjct: 844  TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 894

Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
            +        + D +   T +  + + ++ A   E +   +    +  ++ +  S    W+
Sbjct: 895  EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 951

Query: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8075
            + SE   + P  S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +
Sbjct: 952  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011

Query: 8076 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 8134
               +    E   RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L    
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071

Query: 8135 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8193
                + ++  K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL 
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131

Query: 8194 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 8248
                  CQ+V+ R E     L + + L  D  ++ +   + E+     D  +        
Sbjct: 1132 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1183

Query: 8249 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8308
               +    L  ++ +  R++   +   A V            L+  + S +++A P   E
Sbjct: 1184 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1230

Query: 8309 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 8354
              + + +     Y      L+G    LE          S + +  K L++  F+++ TEN
Sbjct: 1231 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1290

Query: 8355 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 8414
            I     P G E             E S  +DS   LE+ ++  E++ P  + + +     
Sbjct: 1291 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1328

Query: 8415 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8462
             GV+D            RW  L  +A+ ++  ++Q++Q  Q+              TE+ 
Sbjct: 1329 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1374

Query: 8463 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 8522
            L  +Q      D Q       K+   Q   + +K   +  +L S E +  + K+    ++
Sbjct: 1375 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1431

Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 8579
                      RV S ++  +  LQD  M+ + F + ++    + E+   +D  K  +  +
Sbjct: 1432 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1484

Query: 8580 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 8638
            ++ +++ E++Q      + +   L E +  V  +     Q++   +  +  E  E+V  +
Sbjct: 1485 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1544

Query: 8639 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 8679
                  L  +V+   ++LEK L +S   +     L+ W +A +++
Sbjct: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589



 Score =  119 bits (298), Expect = 1e-25
 Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)

Query: 521  SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
            S +++W+ +   + S+ QL       +E          S   EQ    Y +     EM  
Sbjct: 945  SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1004

Query: 572  KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
            KA   +  +        E   +W+ LS ++      LEE ++   +  N + +L+ W+ +
Sbjct: 1005 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062

Query: 632  AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
             +  L +       SE  KK     R L   IQ       ++N+ G  +    +   +  
Sbjct: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1122

Query: 679  LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
            L+ +L  LN +W  +  +V  YA+ + +    K   +  V+L    +E H+ ++    E 
Sbjct: 1123 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176

Query: 735  LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
            LE  F       ++  +++++  ++     +A+ K++T++ + +  ++P           
Sbjct: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1229

Query: 790  SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
              LK++L  +   Y  L          LEE+          L K N+ +  +E       
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1282

Query: 850  LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
             FK K             T   I  G++ + + + +L N+++H +    Q +I    +  
Sbjct: 1283 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1328

Query: 909  QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
              ++ +  +  + +ET +   ++  E     +K+L   ++ ++   + E+ L    E  +
Sbjct: 1329 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1383

Query: 969  QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
             +D++ L A++   D++      QE Q +Q  +      L +  K  QG+     +  +I
Sbjct: 1384 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440

Query: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
            DV + +          ++  + +L  +  + E+ ++E ++   D+   HL     + +E+
Sbjct: 1441 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1491

Query: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
              V+  +   V       + +L E+++ ++   +        K  E+P +  +  +    
Sbjct: 1492 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1546

Query: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
             ++E  + ++  + QL+  K   +      E+    E +      +TKR   +  + S L
Sbjct: 1547 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1603

Query: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
              +V    +++ E +KQ   L  ++   +AL T+L + E ++ +    +    I V +  
Sbjct: 1604 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1663

Query: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
            EE ++   E Q+  E         T+ + +A  LL   ++K         KR+ A+  D+
Sbjct: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1723

Query: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
            + ++   +     L     +  RKL        +  E   R   ++     R +T K ++
Sbjct: 1724 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1774

Query: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
             ++ L Q  S  ++ L     E L +E++Q     +   +  +  +N       +  G  
Sbjct: 1775 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829

Query: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
             +Q +  + K     IK+Q+ + +    +D+++    K      +W  +    + L   +
Sbjct: 1830 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1889

Query: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
             + EK+L +L       + +I +I   +Q+ + +L+++     GL E+  + A    Q  
Sbjct: 1890 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1947

Query: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
             +     I++K  Q RR        +RE    +  E   L        +   +  + Q++
Sbjct: 1948 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2007

Query: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
             E E  L  P        + +K  +   ++  +L+  S  I       TA   SA  V  
Sbjct: 2008 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2066

Query: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
            R    +  + L  Q+E + +  K+RQ   +  +  W+R   ++  F  WL   E      
Sbjct: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2126

Query: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
            ++  + +  K +  L   + LQ+ +  + +    L    E +   +SK D  +++  L  
Sbjct: 2127 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183

Query: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
            L+ RW+++ + ++ R   L+       +F   L  F +W    L E    + I +   + 
Sbjct: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2239

Query: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
               + K+   +V+    EL   QG L +L   G           E+   L+ K +     
Sbjct: 2240 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2297

Query: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
            + + S+ +  +Q  + + + +  Q    L  +  QL   +   + + +N+ ++  +    
Sbjct: 2298 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2356

Query: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
               D  +   A+++    ++ ILSK Q+  K   + Q    +   + L  E + +  LL 
Sbjct: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2414

Query: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
              +++   LA           + +  +    + + T   +L+ P+   L+   L  FN+ 
Sbjct: 2415 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2474

Query: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
              EL        WL     Q+ +       +++ +IN + +    T + + + + Q   L
Sbjct: 2475 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2523

Query: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
             +L+   QNLK+  S   + A ++I  R                E  +N+ +  Q+ L N
Sbjct: 2524 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2566

Query: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
                 +  L+E+ K             +ST  +WL+  E+ E+ + + R  L  W +   
Sbjct: 2567 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2607

Query: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
            T D I+        Q+A+++    +N+D  N L A +LL+++ ++   K   + E     
Sbjct: 2608 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2665

Query: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
               +H +V++ +   +  ET   LQ    DL + L    E  E     L+D    +T+ E
Sbjct: 2666 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2718

Query: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
            + + D                     E +K+ +D+Q E+++      +  EN   + R  
Sbjct: 2719 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2762

Query: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
              S +   L R +  +  K   + +     ++ L+ S +  K    S+QE   W      
Sbjct: 2763 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2822

Query: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
                   +G    A  K++       + L+ K   + + L++V           L+ + Q
Sbjct: 2823 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882

Query: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            E + L      Q V+  +++Q  + N E++         ++ + +    L   ++   +L
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2942

Query: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
            +L + + E  + + + +G+    I   ++ + KV+   GE+   +E++  ++   + L+ 
Sbjct: 2943 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000

Query: 2587 EG 2588
             G
Sbjct: 3001 LG 3002



 Score =  114 bits (286), Expect = 3e-24
 Identities = 347/2017 (17%), Positives = 774/2017 (38%), Gaps = 287/2017 (14%)

Query: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
            Y + L+EV  WLL     L A   + ++ +E +  Q   H+  M ++   + R+ N+   
Sbjct: 340  YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 398

Query: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
            G  LIG        KL ++    +Q   +  ++       A    QS  H +   +  Q 
Sbjct: 399  GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 452

Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
             L++   WL+  +       + PL     +  +QV+  + LQE      DL      +++
Sbjct: 453  -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 505

Query: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
             +      D    +        Q + L   W  I     + W+ LQD   + Q +     
Sbjct: 506  LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 562

Query: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
              E  +    +S+ +D V K+ +      N ++  + KL   +   E K           
Sbjct: 563  --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 609

Query: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
              +QS       ++DL  T          E +L+ F   WDNL +   +STA   +A+  
Sbjct: 610  --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667

Query: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
               +L +      +  +  ++Q +++H     +EL        ++R   ++  I++++ V
Sbjct: 668  TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 722

Query: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
             +T             EL  W        +EA+ QSP     +  +       S+L+ K 
Sbjct: 723  DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 759

Query: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
              ++    +  R + D   + + ++++ +++  +     +D + Q  + LN       + 
Sbjct: 760  NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 814

Query: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
            LSE+  +L     +    +Q+QQ E+     E+   +       P  +  Q+K CK    
Sbjct: 815  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874

Query: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
             L   Q ++  L  Q   L ++                  +Q  S+V  + +ELQ+++D+
Sbjct: 875  RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 934

Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
            +                    ++E       W++Q++  ++ P++++  +   +  +L +
Sbjct: 935  L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 977

Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
             Q +     E ++ L  L  T + +     +E+   Y SE    +  ++  + +   +  
Sbjct: 978  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1036

Query: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
             K++E +   ++  + I+   + ++E++  FL+  + P  L   E L  Q   CR ++ +
Sbjct: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1093

Query: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLVTLYHR---LKRQ 4765
            +  +  +++ +N+  +  ++  +P               Q D M   V  Y R   LK  
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV--YARKEALKGG 1151

Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL 4825
             E+ VSL +D +   + HE M Q  E  L+  ++ + K  +E   A E++K     A   
Sbjct: 1152 LEKTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA--- 1203

Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
            Q     +K +T  +  +     P+A E  + ++++     + L + +       E     
Sbjct: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263

Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMN 4942
              +  + + ++  WL  V+ +L     +    ++I E    +  +  H E+  + +RI  
Sbjct: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI-- 1321

Query: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
                                L  +L +   +D  I E L T  +   E++ +  R  ++ 
Sbjct: 1322 --------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1361

Query: 5003 QAANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 5060
            + +    ++ ++ L L    L    +     +   ++      +      +L S   +L+
Sbjct: 1362 EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLE 1421

Query: 5061 PLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELM 5117
             + K    ++  Q+V S    +Q+  +D   +  L Q+        Q+++   +EV   +
Sbjct: 1422 EMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1481

Query: 5118 NDTEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
               E K  E  ++++  +H     + LSE K+ V +V     +IV  ++  +  E     
Sbjct: 1482 PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE----- 1536

Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
                 L   +T +   +  L A   ++++ LE  +        ++   TE +     +L 
Sbjct: 1537 -----LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1591

Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
              SA +   + L + + +      E+E+Q+  L     ++++ + +      G++  L++
Sbjct: 1592 KRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVE 1646

Query: 5296 E-ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
            + ++ +    + +  + +    L+ +  K  E  +  ++ +  W+ +    L     +  
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706

Query: 5355 AQLEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALD 5406
             Q E+ L+ L  E  + R  ++   ++              L     SEL+ + A ++  
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHR 1766

Query: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KV 5464
            +K   +    +KE+EQ  +              D+  +L  L+A+    V  K +   K 
Sbjct: 1767 IKT-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKD 1811

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
            + E+ +G   +L++    +Q+ +    +  +   K+  +L +     ++   ++  K   
Sbjct: 1812 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKAL 1869

Query: 5525 AASHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE 5582
              SH   +Y    + +LK ++   K LA       S  + R++         + KEID E
Sbjct: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRE 1914

Query: 5583 LEAMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIR 5623
            L+   E+L  +           +    E    Q+++  RE E            Q+  +R
Sbjct: 1915 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1974

Query: 5624 LQNLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5675
             + +    +DM          +  E+  +  AL + +  L +P++     ++     + L
Sbjct: 1975 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2034

Query: 5676 LSEMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5732
             +  +SL+    ++  +   ++A       V  + L  A  +L  +  ++      +   
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2094

Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEEL 5784
               +V ++ ++  ++K   Q +  A + +    +  +         ++ELQ  I + + +
Sbjct: 2095 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTV 2154

Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
             + +    E+I   +SK     ++ K  ++ L   EV
Sbjct: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2191



 Score =  108 bits (269), Expect = 3e-22
 Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)

Query: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
            ++  ED++  + L+++  N D    A +EV +W+    D L+  G + + +      F  
Sbjct: 318  LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 377

Query: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
            HE                  LG +L    ++     + +Q     L+     L  A  ++
Sbjct: 378  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 437

Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
            Q++L   ++D +   + L+ L  W+ + EE       +   +   +   +E+LK Q+ + 
Sbjct: 438  QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 489

Query: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
              +  DL+    R+N L + + + D+           ++++ L   W+ I   T +R+  
Sbjct: 490  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549

Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
            LQ  LL+ Q   E+   +  +L + E  +    +  ++            Q EM S  Q 
Sbjct: 550  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 598

Query: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
            L  +  D    LE+ +      ++LK  LLS      +   Q+    +D+  R W     
Sbjct: 599  LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 649

Query: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
            + +KL K   ++S      + +    L Q   +     V  +E++ ++     +      
Sbjct: 650  LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 705

Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
            K+  ++ DS     L  ++ E+   W + S  + +  +   F      + E   +D  EK
Sbjct: 706  KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 758

Query: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
            +   +++ ++                ++L++A  S        +L++  ++  ++AD I 
Sbjct: 759  VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 798

Query: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
              +E+   L  +W E C  LS       ERLN W  +          L Q+E   +   +
Sbjct: 799  QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 847

Query: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
             L I+          + ++ I ++   +L  +  ++ +   +S A +        ++   
Sbjct: 848  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
                + ++ +   + AR K+L+     +  +   + MS++RTW+   E++L+ P +    
Sbjct: 908  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 966

Query: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
            + E ++++L E Q LQ  +++  +G    L      + +    A        Q     ++
Sbjct: 967  DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1022

Query: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
             RW+ + +  +E   K+EE     +K  +     + W+        E   A   S     
Sbjct: 1023 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1078

Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
             + K++LK+       +      L  +N+  +++  E   + A  L+  + E N +WD++
Sbjct: 1079 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1137

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
             ++V +    LK  + +    +     +  W+T+ + +    + E+ +  ++Q  ++++K
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197

Query: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
              ++E      K++ +      +I ++ P+    +++EL+ L    Q +  R        
Sbjct: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1249

Query: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
                       L+ +   LE+  A     WH+     LLS    +N  L+  +     ++
Sbjct: 1250 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1287

Query: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
              + P   + I    D   +L R  E   +  R L     +G    +         +   
Sbjct: 1288 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1347

Query: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
              L  +  +  K L+ S    Q+TE  +     +   +D     Y+    + +      +
Sbjct: 1348 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1407

Query: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
            +++  L   E SL      +  +     V+ + ++  AQ   +++ MK  L QK   F  
Sbjct: 1408 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1465

Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
             L      L + +  L  L+    S + + ++ Q+     L K++   K+ +  +     
Sbjct: 1466 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523

Query: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
            +  Q    E+ ++L +R++ +   ++ + + + E +  L+  L   +   +  + L   L
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583

Query: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
               D    +++ +  + SNLD+E+
Sbjct: 1584 AATDMELTKRSAVEGMPSNLDSEV 1607



 Score = 65.9 bits (159), Expect = 2e-09
 Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)

Query: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
            PS+  E  +DK F    +   V L    +ALE  +  L  A D  + Q  I     +++ 
Sbjct: 314  PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 373

Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
            +  T       ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++ 
Sbjct: 374  QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 425

Query: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
                    RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L
Sbjct: 426  --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 475

Query: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
              D++ ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  R
Sbjct: 476  GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 535

Query: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
            W  +C   E+   LLQD L++ Q   E        L   +   N+I         E+L  
Sbjct: 536  WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595

Query: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
              K L  +K +L + +  +  L  +   LL
Sbjct: 596  LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 624



 Score = 49.3 bits (116), Expect = 2e-04
 Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)

Query: 134  QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
            Q++ L   LP  Q +    +     V    P  P ++    K++   K+  L+W++ +  
Sbjct: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2304

Query: 194  ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
               KQ  IE  +KD G+  +        ++ +   L  +       N+ N E  F + ET
Sbjct: 2305 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2364

Query: 249  ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 299
            E+          V   +PD + I++      K  P        + + S++ +  + +L  
Sbjct: 2365 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2415

Query: 300  ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 321
                     PG  +   S         Q    ++  I K                     
Sbjct: 2416 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2475

Query: 322  -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 376
             E+  W+   ++ +   +++  +L+D  +     K      E +R Q+E LI        
Sbjct: 2476 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2535

Query: 377  KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 424
            K S  +A          ++  WD V   L +   QL++ L         WL   E A   
Sbjct: 2536 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2591

Query: 425  ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 481
                R ++   +    T + IQ+K+ + K L ++     R +       +   + +  D 
Sbjct: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2647

Query: 482  LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 533
              D   + H ++     S   +H    E    LE  +RLL    L   K  +W+ +    
Sbjct: 2648 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707

Query: 534  ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 579
             +V Q        +E+SK                E +   Y  L + ++  +++    ++
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767

Query: 580  AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 639
            A  + + ++    +W  L  +  ++RS LE     W R   ++  L  WL+  +  L++ 
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827

Query: 640  ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 695
                 DF       +Q+   ++ A    ++T + ++   L+   + L  +      +L+ 
Sbjct: 2828 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882

Query: 696  EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 748
            E ++     +A  + R+ ++  + V T    L+  + +  +K+ E LE         +Q+
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2934

Query: 749  LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 808
            L++    + +   Q ++I        K S Q  G  +  ++    E++  ++   +PL  
Sbjct: 2935 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2984

Query: 809  ESQQLLIPLEELEKQMTSFYDSLGKIN 835
              ++ +  + +L +Q+T+    L   N
Sbjct: 2985 --KENVSHVNDLARQLTTLGIQLSPYN 3009



 Score = 35.4 bits (80), Expect = 2.5
 Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)

Query: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
            ++   WE L    ++ QR + E LER Q+ Q++   +  K+   E+        G     
Sbjct: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2965

Query: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
             + +H    +AL  EI  L++ ++ + + LA +L +   +  P       STL  L  R 
Sbjct: 2966 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3020

Query: 6055 STIRMKASGKRQLLEEKLND 6074
              +++    + + L E   D
Sbjct: 3021 KLLQVAVEDRVRQLHEAHRD 3040


>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
          Length = 3685

 Score =  313 bits (801), Expect = 6e-84
 Identities = 627/3213 (19%), Positives = 1226/3213 (38%), Gaps = 521/3213 (16%)

Query: 24   EQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRM 83
            E+E VQK+TFTKW+N+  +K     + ++LF D++DG +LL LLE L+GQKLP E+G   
Sbjct: 12   EREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST- 69

Query: 84   KRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLP 143
             R+HA+ N+  AL+ L+   + LVNI STDI DG   + LGL+W IIL++Q++ +  N+ 
Sbjct: 70   -RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNI- 127

Query: 144  QLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKDF 203
                                        +    Q N++K LL WV+ +      + V +F
Sbjct: 128  ----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNVINF 159

Query: 204  GKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPEDVD 262
              SW  G+A +++IH+ RP+L D  +V   +S  + LE AF IA  +LGI +LLDPEDVD
Sbjct: 160  TTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVD 219

Query: 263  VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKE 322
               PD+KSI+ Y+    +  P     S +  ++ E+LP  P          +E+      
Sbjct: 220  TTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQLHH 270

Query: 323  MKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQ 382
               + +Q    L +     S+ + +++S+ + +  Y              H        +
Sbjct: 271  QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL-------E 323

Query: 383  ALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTI 442
            A   +S+    S L +  + LD+   A L  + +WL  AE  L+ +  +          +
Sbjct: 324  APEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDVEVV 375

Query: 443  QRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE-LH 499
            + +   H+  + +  AH+     I +  ++ +    +  D+  ++ E+ + ++S  E L 
Sbjct: 376  KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435

Query: 500  LMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQNYVS 545
            +  ME     +R+L  L   + K L  W+ K   R             E +++ +Q +  
Sbjct: 436  VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495

Query: 546  FIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVEVRS 603
              E+    EQ +V    L     +  ++ G    A  E  +K + +   +W N+      
Sbjct: 496  LQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTED 549

Query: 604  VRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDA 663
               +L++++  W R         AWL + E  +N+                  HT     
Sbjct: 550  RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTGFKD 592

Query: 664  GNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVV 718
             N ++ +  ++  +  DL   KQ +  L    ++L   +K  +   + +     +  C  
Sbjct: 593  QNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARC-- 650

Query: 719  TLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES- 777
                        L + LE S   +   +   +    +  VM+    + T+   L+     
Sbjct: 651  ---------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQE 701

Query: 778  ----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLG 832
                P  + K      S+++++L   + E +S +      L  P   + ++  +F D   
Sbjct: 702  ELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE 761

Query: 833  KINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEKGSQ 877
            K+N I          + +    + AL +Q   E +       A ++   + +   +  S+
Sbjct: 762  KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSE 821

Query: 878  SVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK----KFE 933
             +      +N++  ++Q +   Q+      +  +   T      +++  ++ K    +  
Sbjct: 822  RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLS 881

Query: 934  ESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTDILP 990
              + ++E+ L+I    L+EKG     L      F+   ++V   + A  K    + D LP
Sbjct: 882  GLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940

Query: 991  EQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-ETKL 1048
                Q    A+R     W   Q E    +  L + D E       +E+   EL   ++ L
Sbjct: 941  PMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQSSL 989

Query: 1049 MPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKEL 1108
              Q+     +       S K P  +  K     EE+                     K+L
Sbjct: 990  QEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRWKKL 1032

Query: 1109 RAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-KRAV 1167
             + +    +KL E  +K +   +       W++  +  LK    E        E+ K+ +
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILKKQL 1088

Query: 1168 EEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKM 1227
            ++ R  V+     +  ++  L  + E   + + + + +  ++L +  K L T    + + 
Sbjct: 1089 KQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQ 1144

Query: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF------------------ 1269
            +         KE +K  LE+ +S  K++ E  E +   E  +                  
Sbjct: 1145 V------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198

Query: 1270 EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRE 1329
            E ++     QQK  ++      V   IAQA       P    E L+K   TL        
Sbjct: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL-------- 1243

Query: 1330 RQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRT 1389
                    T  +W     N +   + L +  +     LS+  LE  +  L + +   K T
Sbjct: 1244 -------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKLKTT 1292

Query: 1390 ESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWD 1449
            E+I   AE    E SE+    +N   L + ++    Q++ L  TL +     E++  + +
Sbjct: 1293 ENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINEELE 1345

Query: 1450 HFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQS 1509
             F S +  L      ++K L     S+   +  +  I+ ++  I+ +L++ +  + +A  
Sbjct: 1346 TFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQ 1405

Query: 1510 FAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR---KI 1564
              Q     E+ +I++ LT      EE+++H Q  E    +L  +   QK  +++    ++
Sbjct: 1406 MPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRL 1460

Query: 1565 QQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSSAIT 1610
             Q  + FE +L         +K+   A ET  V QE         ++L ++L  + S + 
Sbjct: 1461 FQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVE 1520

Query: 1611 AFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1664
                + R++V      N     +   AL+  Y ++  +  ER+  LE  L   +++ KE+
Sbjct: 1521 MVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEM 1580

Query: 1665 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLF 1724
            +    WL   + + +     +      ++ E+   +A Q E+  Q      + ++ E+L 
Sbjct: 1581 NVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALK 1639

Query: 1725 SVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF 1784
            +V  K +  +++  L  L+  W  +     + +N L       + FD+ +   + WI   
Sbjct: 1640 TVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1698

Query: 1785 LSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1844
             + L  + +      +  L R K   AE+   + ++ S +   A           +L+  
Sbjct: 1699 DTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NLMAN 1744

Query: 1845 KAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTVEAT 1894
            + + C +L E     +  R  A+SH          L E  Q ++ +  +L  L    E  
Sbjct: 1745 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--AEIQ 1802

Query: 1895 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1954
              +N  E D   KD+N+   N   ++      D +        +I    +R   +     
Sbjct: 1803 QGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIKQQL 1853

Query: 1955 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2014
            L  +   +++L   ++ +A  ++     ++ Q ++LLK ++DIE++     L EP  +  
Sbjct: 1854 LQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRDE-- 1909

Query: 2015 QQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINRLEVTWDD 2069
                R   +++ EL   + EL  ++ +A+ +++   A A E     + +    +E  +  
Sbjct: 1910 ----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1965

Query: 2070 TKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI-------- 2115
             +RL    IH  + +   ++  D+  E   + S     + + S  ++    +        
Sbjct: 1966 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2025

Query: 2116 KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFSLVKTDME 2172
            KD EDL   F + E+ KN  +  Q+    +D   SK    L     +         + ++
Sbjct: 2026 KDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLD 2082

Query: 2173 STVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NISNLDNHL 2231
                +W  V++  ++   R   S+  W            W       + +  I     H 
Sbjct: 2083 F---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHA 2139

Query: 2232 RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIEADLMQKL 2285
            + +  LKE +  +  +   +  L++   ++ + +         E    L     ++ ++L
Sbjct: 2140 KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2199

Query: 2286 EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNETCEALKK 2341
               K+  E  K  L +F       ++ +N+   W  + +      L    + +  E L++
Sbjct: 2200 SDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ 2252

Query: 2342 VKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKKHEAVSQL 2395
            VK + +EL  +Q  +    E      +++        +LE+ L +     IK   A+ + 
Sbjct: 2253 VKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2312

Query: 2396 CSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
              + +A +++   LEK   +  ++     L       +       +   +    D+Q   
Sbjct: 2313 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETE 2369

Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQ-D 2512
             +V   Q  ++ +  +GQ LY    K     ++ ++   + E++A + + L++ +A Q D
Sbjct: 2370 IAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPD 2426

Query: 2513 CASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL---- 2568
             A  L +                    T+ +    Q +  K+  + K+EM    +L    
Sbjct: 2427 LAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471

Query: 2569 ------AARESLDKLSQRGQLLSEEGHGAG--------------------QEGRLCSQLL 2602
                  A  E  D LS   Q++  +    G                    Q      +L+
Sbjct: 2472 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2531

Query: 2603 TSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWFWVKAIQD 2645
            T+ QNL   T             E++++    +QEH     + L E L+    W++A ++
Sbjct: 2532 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2591

Query: 2646 RLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA 2691
                AE  LG              + D ++K++++ + +     + +  +++A     + 
Sbjct: 2592 ----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKL 2647

Query: 2692 LRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMES 2751
            LR  + +  R +    E +   W  I       ++ LE        +     +   W+  
Sbjct: 2648 LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTE 2707

Query: 2752 VD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE 2802
             +          + E  L+   G+KE   L+   Q +  E E HT   H L   S+++  
Sbjct: 2708 AETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2764

Query: 2803 KTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYLDAVHEFT 2853
              E        Q  L     D M     ++RK    ++ HL         ++L ++ E  
Sbjct: 2765 SLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL-SLQELL 2818

Query: 2854 DWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRLSRVE--- 2901
             WL    +EL R + + GD  A QK+           K KE +    +   R+   E   
Sbjct: 2819 VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL 2878

Query: 2902 -----------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQTQSCLEN 2946
                        L PE + QN T       E ++TE + L      W+  + +T   LE 
Sbjct: 2879 EGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDET---LER 2935

Query: 2947 LVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2979
            L        QE      +L+  L Q   +  +W
Sbjct: 2936 L--------QELQEATDELDLKLRQAEVIKGSW 2960



 Score =  215 bits (547), Expect = 2e-54
 Identities = 374/2029 (18%), Positives = 815/2029 (40%), Gaps = 216/2029 (10%)

Query: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
            ++ L+ +    Q  + Q++++G      ++   ++    QL   W+     +S+ L+   
Sbjct: 774  FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 824

Query: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
                 W  YQ+      + LQ  +      E W +   T P E   ++  L    +   E
Sbjct: 825  -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 876

Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
            V+  S L+  +     Q + LK+       L ++     + +  + +++ A +++L  + 
Sbjct: 877  VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 935

Query: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
             D LP    +  +S + +W+   E  +   + ++ +   Y+ + + L + +  +  +  +
Sbjct: 936  FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 992

Query: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
            Q  + +++ +V ++S +   E  R  +++F E  G     W+ L   + E  Q LE  + 
Sbjct: 993  QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1048

Query: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
               + +N++Q LK W    +  LK++   +GD   ++  LK C+ L   I+  +  +  +
Sbjct: 1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1108

Query: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
             + G  +    + + +S + + L+EL   W ++   V   K  LK  L++  S +    +
Sbjct: 1109 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1168

Query: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
            ++ ++ +A            + + +Q  V+ ++  +++ +++E  ++      N ++ + 
Sbjct: 1169 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1228

Query: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
             P   E L   L+ +   +  L   +  + ++ + +   W     Y ++    + + E +
Sbjct: 1229 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288

Query: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
                LK   N     +E++  +    +L++     +D+   +  L + L    D      
Sbjct: 1289 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1338

Query: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +++L + +     L +   ++Q  L+  +   +   KSL  ++  +   ++ L     
Sbjct: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1397

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
            +   D + + +  ++++  +        ++ + N   E   R L   D   K++Q+++  
Sbjct: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457

Query: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
            + L      ++ +  +  L + +  L++ +  +          A+E     Q +++ Q  
Sbjct: 1458 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1503

Query: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
            H   L+++    + ++   +I  G++++++ Q ++  E + ++T L   +  +  +  +R
Sbjct: 1504 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1562

Query: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
            +  ++  ++  ++ R+    L +WL   ++     S +  +P  L  +   + +   KE 
Sbjct: 1563 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1620

Query: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
              + +Q  ++ ++    + L +     E  ++ +L+ +   W + + R EE    L    
Sbjct: 1621 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1678

Query: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
            K  E  ++ +         AD+L  L   +KK  Q   D  + L AE     ++   V S
Sbjct: 1679 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1733

Query: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
              D    L   +      +    IS LN R       +  + H++   +  I   L E  
Sbjct: 1734 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1784

Query: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
             F   N ++ + L  +E+++ Q  ++  E+  + + +D +  +        +L Q G+ L
Sbjct: 1785 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1834

Query: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
              + + E K  EI+ K   +  +   L DL + R KK  E      Q  +    L   L 
Sbjct: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894

Query: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
             IE +LA  P   D    +EI R+L +++E    + + + G++             D  A
Sbjct: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1942

Query: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
               E   IQ     L +RWR I    +  RRL         EET  +  +          
Sbjct: 1943 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1997

Query: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
              +L + +     L   E+    P      +    E+L K E   + + + L Q    ++
Sbjct: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2053

Query: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
            +I+ +     +         L++ + + + +W+ + K       R    + +   F    
Sbjct: 2054 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2113

Query: 8118 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
                 WLTE + Q        E    AK K  LK  Q  I      +  + A GE++I++
Sbjct: 2114 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2172

Query: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8234
            S   DA+I++E+L  L    QEV  ++    K+L      L + + DL++  L LE++  
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2232

Query: 8235 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8291
            ++ +         L        L    L L Q +  + +    P  V S P+  +    L
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2291

Query: 8292 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL------- 8338
               L+        +SRALP    E Q + +  ++    L      LE Q+  L       
Sbjct: 2292 ENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2347

Query: 8339 -------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGECS 8381
                    +   +  F +Q+TE  +++K P   E+            + +   + L + S
Sbjct: 2348 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2407

Query: 8382 SSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ 8440
            S   +V RL  +L+ ++  L PG   + ++ TQT  ++ +  + +  A+SK L M  +L 
Sbjct: 2408 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSSLM 2466

Query: 8441 KWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRKAI 8498
                  +D N  W  L D    L+Q+ + +  +  D++ I   I K K   + ++ R+  
Sbjct: 2467 LEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ 2526

Query: 8499 ILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALMQC 8552
            +  +   +     +  ++E+R  + DR+ ++  +WD V   L+  R     +L+D+    
Sbjct: 2527 LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWL 2586

Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
            +   E    L      ++  K     +D+      +Q    +  Q+  +L + Q  V   
Sbjct: 2587 EAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVDVA 2640

Query: 8613 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
             D++ +LL +    D      KVH+I   +    + + + + E E  L+
Sbjct: 2641 NDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2685



 Score =  195 bits (496), Expect = 1e-48
 Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)

Query: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
            +L +    L  ++    ++  W+   E+    +  GE    +   K++ H  E ++ +L 
Sbjct: 333  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 390

Query: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
            A +  +  + Q G  L   G  +  E       +    NLL    E LR   +  Q   H
Sbjct: 391  AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 446

Query: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
              L     + L+ +  W+   ++R    E      D LE    Q+Q   +++ + E   V
Sbjct: 447  RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 505

Query: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
            ++N           SS       ++ QL+ L + WA+I   +      L+ ++ +W    
Sbjct: 506  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565

Query: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
            E +     W+   +  +        G K++  +L  LQ +    ++ E   +++ +L + 
Sbjct: 566  EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 623

Query: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
             ++L    +++S      ++ +   ++        ++K+E+          +  + +  +
Sbjct: 624  KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 669

Query: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
             + +  L + + M   ++ T ++   +K   +       +  R  ++  E+++       
Sbjct: 670  TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 729

Query: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
            EL H+ +    A  +  E ++F+ +    +L  ++   E+E + +  +L+ A     AL+
Sbjct: 730  EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 788

Query: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
            +         EG N D                    +  +E L S+  E C+   +   +
Sbjct: 789  EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 825

Query: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
                + +I  YN L            Q L+Q    A    + WL     T       P  
Sbjct: 826  LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 862

Query: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
             + + + L+  ++ ++     Q ++  +      + ++  KEK +G   + A   A    
Sbjct: 863  PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 917

Query: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
            +K   S++  +E  L+ +   +    ++ +   I+ W+  S+T+  + + S   Y++  +
Sbjct: 918  FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 977

Query: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
            R  E Q LQS L+E    ++     +  + +KA         S+ ++    ++  ++  L
Sbjct: 978  RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1032

Query: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
            S+   E   +L+  + +  +    I+ L+ WM +    L        D  +L  +  +  
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092

Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
             L+S  Q  +  +  +   G+ +     PE    ++ +L+ +   W  +       K  L
Sbjct: 1093 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1152

Query: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
            +G L K  S Q  + +   WM                 D ++  + E +R   E + K  
Sbjct: 1153 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1211

Query: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
               K KLL E V S         +  A        + EL+ L   Y+ +  R        
Sbjct: 1212 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261

Query: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
            E++     E    L+    WL + + KL     + G A      L  L+ L  H  +   
Sbjct: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321

Query: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
             +  +  T  D     + +  +  LE+    W+         Q  L ++          L
Sbjct: 1322 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379

Query: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
             L+++    +D+ L         A +      + QS+  + EI L +MKK ++   A + 
Sbjct: 1380 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1439

Query: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
             + ++   AQ+ L +  +  R+  +      R Q   + +L+++K     +++    +  
Sbjct: 1440 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1497

Query: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
            + S  +   + +K+   V ++++ V        +KT                     G +
Sbjct: 1498 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1528

Query: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
             V+  +    + L + +        EL + V +    LEK L L+++   +   LT+W+A
Sbjct: 1529 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1588

Query: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
                 L      +       ++++  K+ Q+ +   +  +KS+ E GEAL  ++  ++  
Sbjct: 1589 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1648

Query: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
            ++DK+  L S++  + S  +E +  L    K  E ++  +  + KW++Q      A  LL
Sbjct: 1649 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1702

Query: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
            + S  +   Q+    K +  E+     ++++ + +   L+    DH +       ++L  
Sbjct: 1703 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1762

Query: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
               A     K   ++I         S  Q++ + LE E+Q+ V+ ++     + +   + 
Sbjct: 1763 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1817

Query: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
             D E + +  L R + ++Q    R   E+ R  + +   +    + ++    KD++    
Sbjct: 1818 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1865

Query: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
               Q+  +A  ++  W + K    +L   L D +++L ++     E           ++K
Sbjct: 1866 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1913

Query: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
            +  ++LQ K+  +N +  +   L++                  +E   +  +   LN   
Sbjct: 1914 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1973

Query: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +   R+   + +  +  L+         T   H    ++EV  E+     D L   D E 
Sbjct: 1974 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2030

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
                 E+LK +  +LQ+    I+ +  +K   ++     ++  ++E  S L+ +W ++  
Sbjct: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090

Query: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
            + K    +   SV      +     F + +  AE+     Q P   E  K        Q+
Sbjct: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2150

Query: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
             +     +   L A  ++++ +S   DA  +   LG LN R Q + K LSD +  +    
Sbjct: 2151 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2210

Query: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
            +++ + ++ LN+ +   E+   + ++     + QQ + K+   E + LL +++  +    
Sbjct: 2211 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2263

Query: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
               Q  LK   NE  G       +  E  EQ+K E   KL++    +  V +    +  E
Sbjct: 2264 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2315

Query: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
            +E   K+L   +   ED ++  +    WL     Q +I   P           EI +  +
Sbjct: 2316 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375

Query: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
              ++   L+K Q++ ++ P  + +   L  L    + +   L E     L  K   L   
Sbjct: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2430

Query: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
               I A        V + ++ ++   S +E+ +  + E+ A     ++  T+L   + LS
Sbjct: 2431 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2487

Query: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
            L D        + G  E ++E+  K++      +  +P ++  L+T    LK +T     
Sbjct: 2488 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2546

Query: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
                  R+  +++     QEH +   QQL   LK        KEE  +V  +     E  
Sbjct: 2547 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2606

Query: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
            K       ++Q      K++   L     ++D    LA +  R        ++ ++T   
Sbjct: 2607 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2666

Query: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
                 +I + V+E E+ + ++      F  ++ + L WL   +AE +  V  D      L
Sbjct: 2667 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2724

Query: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
             +  + ++++    +++Q  +     + H   E   K  + L  +D    L+  L  ++ 
Sbjct: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784

Query: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
               ++++     ++ L     Q +R +   Q    WL+    EL + A  G D  + ++ 
Sbjct: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2844

Query: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
               H  F     T++    +  E   +  T  PL    G E L Q+   L  E R+Q ++
Sbjct: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2901

Query: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
            R    Q + +    ++      D+Q+  +E +E + + ++       KL +  ++K S  
Sbjct: 2902 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2961

Query: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
                      ++ L + KAL   +    E +  + + A QL   G   S   LS ++  +
Sbjct: 2962 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3020

Query: 5189 WQRWTRLRAVAQDQEKILEDA 5209
              RW  L+   +D+ + L +A
Sbjct: 3021 NTRWKLLQVAVEDRVRQLHEA 3041



 Score =  191 bits (486), Expect = 2e-47
 Identities = 412/2175 (18%), Positives = 864/2175 (39%), Gaps = 323/2175 (14%)

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6656
            + ++L+ G  K+ G  K+    + E+Q+ ++     ++ L  + M     L R ++    
Sbjct: 396  VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 454

Query: 6657 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6715
            QK  + +  L        K   +  G +LE +          Q++L ++   V S    V
Sbjct: 455  QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 514

Query: 6716 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6761
             +V+E+        L +++ +     +++  +    + +L D          ++ L S  
Sbjct: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574

Query: 6762 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6821
             S+ E  +N++      + N+M   L +L  +LK     + +S   ++ L+  +D L   
Sbjct: 575  LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 631

Query: 6822 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6878
              +SVT   E       R   N   +  K     S   ++   +  Q   ++ V T T R
Sbjct: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691

Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6935
             ++    +Q  + L   P   +K  Q+ +D    +     I+E+ SWI+  E V+Q  E 
Sbjct: 692  EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 747

Query: 6936 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6994
             I    G     +  +K    + +   K   +   ++S   +  Q V E   +D    A 
Sbjct: 748  AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805

Query: 6995 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 7046
            +   +N  W     L++E++        +W EY+NN+       Q L+    T E  LK 
Sbjct: 806  E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 855

Query: 7047 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7104
            Q     +  ++++ LK C+D  + +   + ++E+++   +AL +  +    + +  ++  
Sbjct: 856  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 915

Query: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
                Q ++++     +L+ +  ++      ++     I +++ ++   LS  +L     E
Sbjct: 916  NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973

Query: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
             ++ ++  LQ LQ  L++Q+  L    +   ++ K+    ++    +  +E+  RW  L 
Sbjct: 974  IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033

Query: 7225 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
             ++ E  Q  +  +   ++ +++ +     + + +    E   A  + +I   +    ++
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1089

Query: 7285 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7341
             C  L+  + T++ SL  ++E G+++K + +   AS ++++   L+    H+C   Q + 
Sbjct: 1090 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1146

Query: 7342 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7401
             ++ +L+ G+    +  K L  +  W+ +AEE    +D  + +    +Q+ +EE+K    
Sbjct: 1147 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1205

Query: 7402 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7454
            +       +  L E     +    P+  + +K+ ++ L  ++  + ++   +   L+  +
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265

Query: 7455 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7512
               H+  ++LEK   W+   V+ + K    I G  + + E     +  +  M   +   +
Sbjct: 1266 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1321

Query: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7572
             I I  Q L + G +D+    N +L   +++W+ +   A +R+ +++  I+  Q   +  
Sbjct: 1322 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379

Query: 7573 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7631
              +++ L               I  Q A  + D+V   +     Q+  S + + E   + 
Sbjct: 1380 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1426

Query: 7632 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
            +   + G EAA Q  L++I   Q+K +  SM+    +K   F        E+ + +S   
Sbjct: 1427 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1477

Query: 7689 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7746
            L   K  L   ++     E + ++   C  L  ++     ++  +      +      ++
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537

Query: 7747 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7806
               L+ERV  L+  + EL  +++ R+QQ+ + L       ++   L EWL   + ++++ 
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597

Query: 7807 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7860
                +E M   L       K  Q+EI   + +   + ++GE L K     K + +E KL 
Sbjct: 1598 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1654

Query: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7920
             +N  W  +       +  L E    ++  D+N+  +  W+   ++ L           +
Sbjct: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1703

Query: 7921 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7980
            E ++K  +Q+E              VL   +  L+D        + DS +    NL    
Sbjct: 1704 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1745

Query: 7981 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 8039
             + C   +E ++                         SE    F + S  I T  A   L
Sbjct: 1746 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1780

Query: 8040 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8094
            K+ E F   + + L  LE      +N +     ++   D+  ++K+++    QR DNLQ+
Sbjct: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1836

Query: 8095 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8154
            R+T                                             + K +++K  QQ
Sbjct: 1837 RITD--------------------------------------------ERKREEIKIKQQ 1852

Query: 8155 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8214
             +   HN ++ + +Q  +         A  I  +  + +R   ++   ++   KKL  LP
Sbjct: 1853 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1904

Query: 8215 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8274
             P DE  + + + EL+      +L+   R A+ L   +  + +++   Q   S+R     
Sbjct: 1905 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1960

Query: 8275 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQ 8334
                    L +   + +  +    M+  +P E                 +S   S   ++
Sbjct: 1961 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-----------------ISYVPSTYLTE 2003

Query: 8335 IRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
            I  + +AL     +++Q  N         P+L             C+   + + + E  L
Sbjct: 2004 ITHVSQAL----LEVEQLLN--------APDL-------------CAKDFEDLFKQEESL 2038

Query: 8395 KEEEESL---PGFVN-LHSTET---QTAGVIDR-------------WELLQAQALSKELR 8434
            K  ++SL    G ++ +HS +T   Q+A  ++R             WE +      ++ R
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2098

Query: 8435 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVD 8493
              ++++KW++F+ D+     WL + E+ L + Q  E          + K  LKELQ  + 
Sbjct: 2099 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIG 2153

Query: 8494 HRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 8552
             R+ ++ ++N    E  Q  SK ++  LQ++L  +N RW  VC  L + +  L++     
Sbjct: 2154 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2213

Query: 8553 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 8612
              F    +  +L LE  D   +  +P++   + + L++  +Q+  +  EL   Q  +  L
Sbjct: 2214 SEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQL 2270

Query: 8613 QDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKL 8659
             +    +LV+A    E  D LE K K        +   L     E+   IK+L    +KL
Sbjct: 2271 NETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKL 2330

Query: 8660 LDVSSSQQDLSSWSS 8674
             D+      L  W S
Sbjct: 2331 EDLEEQLNHLLLWLS 2345



 Score =  187 bits (474), Expect = 5e-46
 Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)

Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
            E     ++  L   WE L+    EKQ  L+  L + Q +    L    TK E    K+ E
Sbjct: 417  ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 476

Query: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
             P        + Q+ +H+ L +++   Q  +N L   +   +V +    D A   AL+  
Sbjct: 477  EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 532

Query: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
            L VL +R + I      +  LL++ L   L+ QR  +EQ L           +WL   + 
Sbjct: 533  LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 580

Query: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
             ++   +   K+  +M + L     +  ++E+K  ++ +L    ++LL  L+ K+ T+  
Sbjct: 581  AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 640

Query: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
               L    R       +L+ S  ++ +A+   Q ++ Q T  E     V    T+   + 
Sbjct: 641  EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 696

Query: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
            +   +       Q++  +    E+ + L    + L S  +R E +L              
Sbjct: 697  KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756

Query: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
                     I+   AE      DA      L +++  EG  +     A +Q+  +W    
Sbjct: 757  SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 816

Query: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
            Q  S +   L+   N++      Q+ EQ+  +  N L   +       PT  KS +    
Sbjct: 817  QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 874

Query: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
               + L GL    E +  QS   K +              + H +Q   D          
Sbjct: 875  DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 934

Query: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
                         +SA  TW+   E +L +    +   E  E  L   + L   ++E   
Sbjct: 935  IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 994

Query: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
             +        + +K   S+   +     + IE       GR   L S + + C +++E++
Sbjct: 995  GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1047

Query: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
             ++   QN ++ L   +A+    + ++   + +  +  +Q++  +     ++     +  
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1107

Query: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
            +   G K++ E +P        EL +L   +D +   + +R+  L   L      ++ L 
Sbjct: 1108 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1167

Query: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
            ++ + +   +E+   ++     + +E+Q+ ++   + KE  Q  E+ + +LTE++   I 
Sbjct: 1168 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226

Query: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
                    A++KE +    L      +  R + +   LE +   W  L    ++ ++ L 
Sbjct: 1227 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1283

Query: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
             VE  + +     G  EE  + L     L +H + + N+ +  L Q L DG         
Sbjct: 1284 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1333

Query: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
              ++  +N+  E + S   ++ +E  R + +L+   +   E+   +H +Q   + L F  
Sbjct: 1334 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1390

Query: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
            +Q          +  +PQE + ++  L +     +E+   +  K +     +Q+ +  KK
Sbjct: 1391 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1450

Query: 6872 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6914
            +   +++  L +  + +   L            ++PA++ K  + ++ +    H      
Sbjct: 1451 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1510

Query: 6915 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6956
            ++SEV S + ++      ++QK + +N K             N +G K      Q  K  
Sbjct: 1511 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1570

Query: 6957 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6986
            K+    ++             ++   +S ++               + +++E ++     
Sbjct: 1571 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1630

Query: 6987 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
                           +T   ++L  +N +W  +     E + LL    +    ++ NV  
Sbjct: 1631 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1690

Query: 7034 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7086
            +  W    +  L +  +           K  Q  ED++K  + E       V+       
Sbjct: 1691 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1739

Query: 7087 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7144
             L+ N+ +    +V   + EL   +A + H +  G+  I LK +    S  +   + + +
Sbjct: 1740 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1799

Query: 7145 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7198
                   L E  ++        G+++ +  + DNLQ    D  K+E        I  QLL
Sbjct: 1800 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1854

Query: 7199 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7258
            +  H        N LK++  +      EI+ Q          W +YK  +      +   
Sbjct: 1855 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1896

Query: 7259 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7318
            E +   L +    + I             ++ + L   K+ L  +    E L +     A
Sbjct: 1897 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1941

Query: 7319 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7358
            A A++  Q+ LS+    +E    +            ++ ++     D          T+ 
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 2001

Query: 7359 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7416
              +  +   ++E E++L   D       DL   +E ++ +K  + + S     +      
Sbjct: 2002 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061

Query: 7417 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7473
              +     + +K  + L++    W  ++    +R  +    + + + F    + + ++L 
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121

Query: 7474 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7532
            + EQ L   +I  N++H   +    EL Q  +  RQ ++ ++   G+ +++Q    D   
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2180

Query: 7533 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
               KL  L+ +WQ V ++   R+  ++ Q      ++    +   WL E        + S
Sbjct: 2181 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2235

Query: 7593 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7647
            +P+     QQ +   ++V+   +    +QG      E G  +L+SA    E    L+ +L
Sbjct: 2236 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2295

Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7704
             +   +W   S  L E++ ++   +KD  + EK + D  E+L      LS     L  ++
Sbjct: 2296 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2355

Query: 7705 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7762
            +         +E E AV +   D+ +  +L      Y        +  ++E L  +W+  
Sbjct: 2356 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2413

Query: 7763 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7784
              L  +L  ++  +   L                     E A+                 
Sbjct: 2414 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2473

Query: 7785 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7838
             F+    EL +WL+ ++  +       GD+  I EMI K K   Q+     ++ + QL++
Sbjct: 2474 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2529

Query: 7839 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7887
            +    + L  K S++   + I  ++ ++ ++W  + + +  R ++L E        L A 
Sbjct: 2530 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2589

Query: 7888 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7947
            ++ ++ +   R   A +ES    P   D+     IQ+K+ E ++L +D+ +  T V    
Sbjct: 2590 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2641

Query: 7948 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 8007
            +L   LL D  A  T      +   T N++  WR+I     ER   +EET RL Q+F  D
Sbjct: 2642 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2697

Query: 8008 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 8056
              +F  WL  +E TA               S GV     KE +K+++  Q ++       
Sbjct: 2698 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2752

Query: 8057 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
              +++  +++ R    +D A  L++ +   N +W  L+K+  +I   L+    Q +    
Sbjct: 2753 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2812

Query: 8116 ARDSILVWLTEMDLQLT 8132
            +   +LVWL   D +L+
Sbjct: 2813 SLQELLVWLQLKDDELS 2829



 Score =  179 bits (453), Expect = 1e-43
 Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)

Query: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
            +L E+     +YQ +L+ + + + + E  L    E     E    Q   H+  M ++   
Sbjct: 333  SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 392

Query: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
            Q  +  +   L  +L+    +    E+  +Q  + +L  R   +R+ +  K+  L   L 
Sbjct: 393  QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450

Query: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
            D      Q Q L+       EL+ WL  T+         P  P   D++ Q+   + +  
Sbjct: 451  DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 498

Query: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
            ++EQ+ V ++ L+    V +E+      A  +++ + L  +              L+  L
Sbjct: 499  DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 558

Query: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
            L+ QR L ++Q        EKE++   +  T      E L            SSLQ+   
Sbjct: 559  LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 605

Query: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
            L+ +L ++K  +  + S  +++L        +                  +K+ A  D  
Sbjct: 606  LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 647

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
               W++L Q+       L+    Q  + V  ++P+   + V      V T+++  V    
Sbjct: 648  ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 696

Query: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
                 A EE+       KRQ      + ++L   ++   +W+   E  L        +  
Sbjct: 697  ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 745

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
            E  +F +E    D+KE    +++ K          +  +QA  E   N  V  D++    
Sbjct: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805

Query: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
             +L+   S   + C  + ERL        I+ F N L+ L   T+ A+N ++ +Q     
Sbjct: 806  EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 861

Query: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
                +  Q++  +   + L      I  LK +   L+ +      L        + + ++
Sbjct: 862  EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921

Query: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
               + +R   L    +     +Y+  +  +   ++  + K++       D +I+     E
Sbjct: 922  FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
            +Q L    +E   GL       + + +K  S   +K      E+  +    +S +++   
Sbjct: 982  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041

Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
            K   ++  + +  +H+   ++ ++     ++   P++G    + + L  ++   + L S 
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1097

Query: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
            +   QP L  V + G+++         S LE++L +L   W     ++      L+  L+
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1157

Query: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
                 Q + +++  W+  A++  E+  +      P EL+   + +    E +++ +A+  
Sbjct: 1158 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1215

Query: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
            L +   S  + + +   V    L+ EL  + + +  L T +    + L ++         
Sbjct: 1216 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1273

Query: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
             + +   W++ +E  + K  +NI    G + I E L   +      N  + + D  NQ  
Sbjct: 1274 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1322

Query: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
            ++I +Q +           E+L   N  W+ L      + +LLE  ++S  E E ++  +
Sbjct: 1323 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1382

Query: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
            +      +K+L     I D+       ++ Q ++  + + E  +E+++++          
Sbjct: 1383 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440

Query: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
               + + Q K +DVS         L Q  AN +  + + K++L                 
Sbjct: 1441 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1479

Query: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
                 E +  L      +   E VQ Q+++  NL   L + +  ++       Q++++  
Sbjct: 1480 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534

Query: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
                + L   +  + + +N L  ++ E+ Q  +  L+L ++ +   K+     +      
Sbjct: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1591

Query: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
             EL K +  + +    D EVA W +      K +   K  L  + E+GE LK  +     
Sbjct: 1592 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1645

Query: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
              +  D+LSL         +  ++  +L   +L+Y    ETF ++++ +  WI++A+ +L
Sbjct: 1646 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1702

Query: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
                    S+    Q++ + LK    + + + P +D   +    L  N  +  R      
Sbjct: 1703 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1756

Query: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
            +  LN  ++ IS +  T + S     L Q  + ++K    +E  +Q    L  E      
Sbjct: 1757 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1814

Query: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
               +    +E    E+  R   L   I D ++         R+E  +K  LL  +   + 
Sbjct: 1815 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1862

Query: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
                QRR        QW +Y+  A+ L K L ++       L S+P P        DE +
Sbjct: 1863 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1911

Query: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
             KE     Q+    L     +   LS D GA  A++    ++ ++W+    +   Q ++L
Sbjct: 1912 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1969

Query: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
             F          ++   E     I+       T    +SQ+L +  + L+A  +  K+ E
Sbjct: 1970 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2029

Query: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
            +      ++ +  D L Q S   D +     +A  SA  +    L E +  L  QWE++ 
Sbjct: 2030 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2089

Query: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
                 R+ +    + +W  F    K   +WLT+ E  + +     I E  E  K     K
Sbjct: 2090 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2146

Query: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
            + Q+ I   Q     L   GE + + S ++ AS ++ KLG +N RWQ +   ++ R K+L
Sbjct: 2147 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2206

Query: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
            +E    + +  ++++    WL   ++  + P+  +    ++++ KL + + L  ++    
Sbjct: 2207 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2264

Query: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
             G+   LN     VL+    A  +  E D ++   +  + +W  +     E++ +IE   
Sbjct: 2265 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320

Query: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
             +  +L +K  D   +      WL              +   F      I   AK+    
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380

Query: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
                       E    +  +R++ +  ++ + +N+  + L R  + D A  L  +     
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2439

Query: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
            Q    + + V    T+I +      L   +    +F  A   +  WL+ +D  ++   + 
Sbjct: 2440 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499

Query: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
                 D+   I + KA  Q++     ++E++I   + L  K+   +A  II + ++ ++ 
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559

Query: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
               EV   ++   ++L  +     +   +  E E     A + L        ++ + Q  
Sbjct: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619

Query: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
               +  LA+ LR                 +W  + D++ DL   + R   ++D       
Sbjct: 2620 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2662

Query: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
             ++    +      +S   +ALE   R L +  LD  +F     + + T N+++  T   
Sbjct: 2663 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2722

Query: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
              L+ S       K +  L GE  +  D    L+   ++   SL G  +    + +   +
Sbjct: 2723 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2782

Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
              +W  L+ ++L+    ++ +  +W++ +  L  +  WL   ++EL +  +  +  D   
Sbjct: 2783 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2840

Query: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
            ++ Q    +  ++ +  ++ +I+S       F      E                     
Sbjct: 2841 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2900

Query: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
            +R L+ +  ++N  W+++     +W+  + + L + Q   E +  L L L   +  K   
Sbjct: 2901 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2960

Query: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
             P+  +L  + LQDH +++  ++ E+   +  V+ + D++ QL
Sbjct: 2961 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002



 Score =  179 bits (453), Expect = 1e-43
 Identities = 362/2009 (18%), Positives = 800/2009 (39%), Gaps = 202/2009 (10%)

Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
            RYQ+   +++ WL SA+D L    Q    +  ++E+V+D  +    +  ++ A      +
Sbjct: 343  RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 398

Query: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
            +L  G++L+   +L + +   ++ +++ ++S+W  L       Q  LH++ MD       
Sbjct: 399  ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 456

Query: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
            + E+  W++  E   +K E+        + +   +Q++K  + D+  +Q+ V+ +   V+
Sbjct: 457  LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515

Query: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
             +   D  S         EQL  +   W  +     ++  LL+ +L  W           
Sbjct: 516  VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572

Query: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7090
             W   +E  + + H  G  DQ  + ++L+    L+  ++ K++ + K+   +Q+ L+ ++
Sbjct: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 632

Query: 7091 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7121
            NK                              +S  V +T   L QT     +  +  + 
Sbjct: 633  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 692

Query: 7122 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
            +IL+K   ++          ++  D     +++  + E    ++R   +  S E A+  +
Sbjct: 693  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 752

Query: 7170 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7218
              N  +L++ +   ER   +KF           ++  Q++ E      +++    +++N 
Sbjct: 753  EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 810

Query: 7219 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7275
            RW    + ++E+L         W  Y++      + +QQ E  T      LK        
Sbjct: 811  RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 862

Query: 7276 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7335
               + + ++ C D +  L  ++  +  L      LK++        + +D ++ + H   
Sbjct: 863  PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 920

Query: 7336 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7393
            +   +  ++  LQ     L    + +++ A+  W+ ++E  L     S  +D   +++R+
Sbjct: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 979

Query: 7394 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7447
             EL+            L  L+    E+  + P  ++ K     + +   W  +SSQ  E 
Sbjct: 980  GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1039

Query: 7448 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7505
              KL+  + + +      +T  +++ + +  L  E    G+ + L +Q +   L  +++ 
Sbjct: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099

Query: 7506 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7565
            + Q  L+S+   GQ++  + + +       +L  L+ QW  + ++   R+  +   + + 
Sbjct: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159

Query: 7566 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7623
               ++   ++ +W+   E  YL        P  LQ+A    +E++  ++   +++    L
Sbjct: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1216

Query: 7624 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7683
              E+   ++  A   A+ AL+ EL  +   ++    RL  + K L  +   W +    + 
Sbjct: 1217 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1276

Query: 7684 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7741
             + + L    FK K ++++P   EE+         LEN +    D+  Q+ +L  TL+  
Sbjct: 1277 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1333

Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
               D++  +NE +E    +W EL H+ ++RRQ++ E+  + A  +EK+  L         
Sbjct: 1334 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1381

Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7856
                     I+E +  + K     IA    +K+   QM +   K      SHE    E++
Sbjct: 1382 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1428

Query: 7857 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7910
             K  +  +  Q +L  I    KKL++  +  +   K       +   +  L  ++  L  
Sbjct: 1429 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1487

Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
             +   S   E +Q +LN    L + + +  + V  V+     ++              + 
Sbjct: 1488 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1542

Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8030
            +    L   +  + A   ER+ ++E+  +L +K   + +   +WL +++      S+   
Sbjct: 1543 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1602

Query: 8031 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8085
            + +    E+   +A Q+++ +    L+ I +    L      +E   +   SL       
Sbjct: 1603 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1656

Query: 8086 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8145
            N  W  +  R    L  L  +    E F+   D I  W+ + D  L   E       +  
Sbjct: 1657 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1716

Query: 8146 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8205
            +K+LKA   +I     K++    Q   L+         ++E ++ EL      +  R++ 
Sbjct: 1717 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1773

Query: 8206 YHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLSLS 8260
                +    L     D    L   E E++    L +  ++ D + D+  + +       +
Sbjct: 1774 GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833

Query: 8261 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAM-SRALPSEDEEGQDDKDFYLR 8319
            L Q +  ER   +       +  +    ++  +DL S    +AL    +  Q     Y R
Sbjct: 1834 LQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKKALEISHQWYQ-----YKR 1884

Query: 8320 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8379
             A  L      +E ++  L +  D+ +  I++ +  ++ K      +    +G  +  G 
Sbjct: 1885 QADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQKKKEELNAVRRQAEGLSED-GA 1941

Query: 8380 CSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL 8439
              +   +  +L  + +E E     F  L+  +  T  V +   ++  + +  E+    + 
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT--VREETMMVMTEDMPLEISYVPST 1999

Query: 8440 QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAII 8499
                 + +++  +   L + E+ L        + D + +  Q + LK ++ ++      I
Sbjct: 2000 -----YLTEITHVSQALLEVEQLLNAPDLC--AKDFEDLFKQEESLKNIKDSLQQSSGRI 2052

Query: 8500 LSINLCSPEFTQADSKESR-DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH-- 8556
              I+       Q+ +   R  LQ+ LSQ++ +W++V  + ++ +G    ++ + + FH  
Sbjct: 2053 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2112

Query: 8557 -EMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 8615
             ++ +  L   E   R+      I  N +    + + K+L      + + Q  V +L   
Sbjct: 2113 IKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNAT 2165

Query: 8616 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS 8674
              +++  +  TD    +EK+  +  R + + K++S   K LE+  ++ S  Q+DL+ +  
Sbjct: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225

Query: 8675 -ADELDTSGSVSPTSGRSTPNRQKTPRGK 8702
              +E D   S+    G+    ++K  + K
Sbjct: 2226 WLEEADNIASIPLEPGKEQQLKEKLEQVK 2254



 Score =  179 bits (453), Expect = 1e-43
 Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)

Query: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
            H+ ++++L   Q  +G + Q    ++  G   +  EE  + +++  +  R  CL +    
Sbjct: 382  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 440

Query: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
            K +N   V  +L+++++ E     +  W+ +T+E      +E +    +L+ L  +   H
Sbjct: 441  KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 493

Query: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
            +   E + +EQ +   L    ++  E S   A  AL+ +++   D+  +  +  E     
Sbjct: 494  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553

Query: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
             Q++  + Q+L ++       L  K D V +  T       E+     KL  L A ++K 
Sbjct: 554  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612

Query: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
                        + +GKL  L Q  +   +N+ S   +  + L+ +    + +++ +EK 
Sbjct: 613  ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 660

Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
                       S +Q+ +     Q  L +           T  ++ +T+V   E++  + 
Sbjct: 661  -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 698

Query: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
            A+     EEL      + + +   ++  K+ + ++ +L + + +++A L SPE      +
Sbjct: 699  AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 753

Query: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
               S  +  ++ +E  + K +  +  Q A R  + +V  +      A  +++ + +L   
Sbjct: 754  GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811

Query: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
             I+ C ++   +  ++Y+     +  +++ L+Q+   A   ++ +P   S    +++Q+ 
Sbjct: 812  WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 871

Query: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
              ++   ++ G Q QI  L  K + + +K K               +G   LD + +   
Sbjct: 872  ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 915

Query: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
            +    V      R   L      L P+  +       + +       S   ++ TD  + 
Sbjct: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975

Query: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
             Q +   QAL +   +  +   + ST+  +   +   E S    ++  +++  W+ L + 
Sbjct: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1035

Query: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
            + E  + L E + + +K Q+ +Q++   M  +++ L E  P  G S   + Q+ + + L+
Sbjct: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1095

Query: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
             +I  +Q  +N +     +++ +E   A+P     L++ L  L  +   +  +   +++ 
Sbjct: 1096 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151

Query: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
            L+  L   +  Q+    +  +  +A+E      +   T   L  A+   K   +   Q  
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211

Query: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6184
                +L E    V+A +   V  E L  E +  T +  + L  +L     +L E+    H
Sbjct: 1212 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1269

Query: 6185 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6243
            +    ++   +   E +  L  T++ PG  E                     E+ + L  
Sbjct: 1270 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1308

Query: 6244 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6303
             ++L+R       +I I    A+T  D G   +++++EL          +    +W  LH
Sbjct: 1309 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1355

Query: 6304 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6353
            +E   +QKLL+  ++  QE        Q   +  ++ L+     K D     Q+   + S
Sbjct: 1356 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1415

Query: 6354 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6405
             L     + EE+   + G +        I + QK    VS          + E+RL  + 
Sbjct: 1416 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1475

Query: 6406 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6448
             +L E        ET    QE+          L K + E+  E++       Q    +  
Sbjct: 1476 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1535

Query: 6449 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6508
            +N   +++ +  L    + L + V +R  Q+++ L+     + ++ VL   LA     + 
Sbjct: 1536 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1595

Query: 6509 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6568
            ++ A   E   +     +   +   KE +   + LK      +V +     L K + + +
Sbjct: 1596 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1650

Query: 6569 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6611
            + + ++ S      S   + L L  +Y++ ++               AD L    EK   
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710

Query: 6612 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6669
             QK  ++   K E+  +  K         + M       RK++   +       +EL  +
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1763

Query: 6670 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6724
             +A+  R    K  + L+        L++   ++ + LE +E+ I   V L EE  N+D 
Sbjct: 1764 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1816

Query: 6725 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6784
              D     + L    +  Q +   + D+ KR  I I    L+++ N L +       K  
Sbjct: 1817 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873

Query: 6785 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6839
            +  H+       W +Y+ ++ DL+  L   + +L    +     +   + +EL+  ++ L
Sbjct: 1874 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1926

Query: 6840 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
            NA    ++ +    +  +              + S   Q  RL      T+R E   + +
Sbjct: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986

Query: 6887 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6943
            +   L ++ +P+  + E  H  Q        A+ EV   ++  +   +  ED  K     
Sbjct: 1987 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2038

Query: 6944 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 7003
            K I + LQ+  G +IDI   + T      + LQ S+  VE     +    E L  ++  W
Sbjct: 2039 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2085

Query: 7004 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 7061
            + +  +  ++    +  +E W  +  +++    W    E+ L+  Q     + A  +  L
Sbjct: 2086 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2145

Query: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
            K   +L+D I  ++  V  +   G  +IQ   +  +SI+   L  L   W  +   +   
Sbjct: 2146 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2202

Query: 7122 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7181
            K  L+   +  S  +   ++   +L EA  +++   L  G  + ++ +++ ++ L ++L 
Sbjct: 2203 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2261

Query: 7182 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7235
             ++  L++       +L      P   + L N LK+ N++W      L E+  E     K
Sbjct: 2262 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2321

Query: 7236 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7287
             L QL ++ +D  +Q        S ++ Q +  N+  +     D+ + E+A   +  D  
Sbjct: 2322 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2380

Query: 7288 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7323
            ++L KG    K+          L +L  + K      Q++ A             AS  Q
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2440

Query: 7324 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7381
            +  L ++Q +   E A+ K +  +SL   V     F ++   L  W+   +++++ Q   
Sbjct: 2441 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499

Query: 7382 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7434
               DL  I E + + K  M       P L+ L      L    +++E +     R++ + 
Sbjct: 2500 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2558

Query: 7435 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7494
              W  +      R  +L   L     +LE  E   + L Q   KL     G Y     Q+
Sbjct: 2559 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2618

Query: 7495 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
            +  E  Q     RQ   +  + +    +LL     DD  + ++    ++  W+ + +R  
Sbjct: 2619 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2678

Query: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7611
            +R   ++   R  Q++    EK   WL E      +    +    ++ R L D    KE 
Sbjct: 2679 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2734

Query: 7612 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7662
             K +   QG        Y    E  +++L S +   +A  LQ  L  +  KW     +  
Sbjct: 2735 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2794

Query: 7663 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7714
              +  L      W++    + + L  L+    +LS+  P            ++H    R 
Sbjct: 2795 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2854

Query: 7715 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7760
             + +  V   T +  ++ L +  L                  A +++ +L ++ E +  +
Sbjct: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914

Query: 7761 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7817
            WE+L    +  +++I E L       E   EL   L Q E         GD+LI+ + + 
Sbjct: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974

Query: 7818 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7875
            L+  K  + EIA  +EN   +  +  +L     +     +   L  +N RW+ L   +  
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3033

Query: 7876 RVKKLKE 7882
            RV++L E
Sbjct: 3034 RVRQLHE 3040



 Score =  176 bits (446), Expect = 9e-43
 Identities = 468/2732 (17%), Positives = 1059/2732 (38%), Gaps = 408/2732 (14%)

Query: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
            S E+ +    E+    E + D  +  E   + L  HQ +   I         Q+     G
Sbjct: 357  SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 408

Query: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
             G L +       E++  L S  + L   S E+Q    R+ + L+  +  E N + + + 
Sbjct: 409  TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 467

Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
              +T    E  L    LE L  +++Q K   +  E   V+  +L      V E+S    G
Sbjct: 468  EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 522

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
                  L++Q K + ++   +    E+    ++ +  KW          S W++EKE  +
Sbjct: 523  DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 582

Query: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
            N + T+      +M  S  K+ + + +        LE++ QS  +  +  +      K  
Sbjct: 583  NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 634

Query: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
             + +  E  L   A+C +  +       QK E++  +I Q+V+  +  L          T
Sbjct: 635  SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 677

Query: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
            +T             +E++++  T      R+ +      +E      Q        K+R
Sbjct: 678  QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 712

Query: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
            Q  +++ +   +RL+ +++   +W+ R EA   SPE  I           + + A++ E 
Sbjct: 713  QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 769

Query: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
              +A  + KL     S  ++  +      +   +K   EQL+ RW +  Q++++R+N+L+
Sbjct: 770  --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 827

Query: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
               +++A   + QQ +++  +   W+K+   +  T SE + +  Q+ +   KD    +  
Sbjct: 828  YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 882

Query: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
             + +++ L+     L   G+      L          F++    V+ R+  L  + + L 
Sbjct: 883  LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940

Query: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
              +   ++S I   ++Q  T  +   ++  + +++E+ L +      +L+     L  + 
Sbjct: 941  PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 1000

Query: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
            +  +   K   SE     ++  +++ G  +++ + L     + +      +  Q+  + L
Sbjct: 1001 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1060

Query: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
             K + +++    +E       + L+++L+    L  ++ + +  L  + +  ++I  + +
Sbjct: 1061 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1120

Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
              FA  ++ E+  L   WD   + ++  +    G ++     Q   S + + +  A    
Sbjct: 1121 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180

Query: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
            + R    K  ++L+ A  + + AK +   K+  +   T     ++++   +       +K
Sbjct: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1237

Query: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
             ++E+    +  +  +L      L    + W ++LS  ++   W N    ++   +   +
Sbjct: 1238 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1293

Query: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
            N     E + E    ++N     E+  +++  L +   +     +L   E +        
Sbjct: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353

Query: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
                 V +  L + + QS Q  EK ++ I    T +++ L     ++   A      + +
Sbjct: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1408

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
            E Q  QS+++S + +L  +  K H+   E+  R ++ +    + +  +  K +   + + 
Sbjct: 1409 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1465

Query: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
              +F + +QE +      K        ++ + +V++++L+   N+  S+S+ +S+++ V 
Sbjct: 1466 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1523

Query: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            + G+ +      +    + E++T     +     +  + KQ L+ C         +   L
Sbjct: 1524 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1583

Query: 2528 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2569
              W+     E+ +R   E +          G++ Q   EK+      + +V   L  +L 
Sbjct: 1584 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1643

Query: 2570 ARESL--DKLS------------------------------------------QRGQLLS 2585
             +E+L  DKLS                                          Q   LL 
Sbjct: 1644 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703

Query: 2586 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2639
            E      Q+     + L +  N +R     T+++  +      +H  + +E  +  +   
Sbjct: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1763

Query: 2640 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2685
              AI  R+   ++++  K+ LE+  S IQ  LL   E E++  + +              
Sbjct: 1764 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1821

Query: 2686 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2737
            G  ++ L+  +   QR+   +     ++   ++ +  +A   L S        +  QW  
Sbjct: 1822 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1881

Query: 2738 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2791
            Y  + + L + ++ +++K+    +P+   K K +        + L ++  +AE  +    
Sbjct: 1882 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1941

Query: 2792 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2851
             +  +  ++         +    +  +  F  I TV +E M  + E +   + Y+ + + 
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 2000

Query: 2852 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2905
             T+  H ++     E+L    D+ + D     K+   +K + DS +  + R+  + S   
Sbjct: 2001 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2060

Query: 2906 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
               Q+ T      +   +  L   W++               V++M    Q   G+  + 
Sbjct: 2061 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2102

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3019
             +   +F   +K + Q LT  E      +I E W         +E+ D + + +     L
Sbjct: 2103 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2162

Query: 3020 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3074
             +   E+ + S   D S    K+  L   +  +C Q S   K  + ++ IL + F++   
Sbjct: 2163 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2221

Query: 3075 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3132
            +F  WL  A    +   + P    ++   L++++  + E    Q  L  +   G   L+S
Sbjct: 2222 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2280

Query: 3133 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3185
              ++ E+   ++ K+      W      L +K+  +E        L+ +++D E     +
Sbjct: 2281 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2340

Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
              WLS     +      +Y+ P  +     +Q     +   +P +  +  K Q L++ + 
Sbjct: 2341 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2394

Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3284
            A++  + ++  LSS++ A++ L +E  ++       L  I A   Q              
Sbjct: 2395 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2454

Query: 3285 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
                                F+    EL DW++    ++ S      D   ++   +K +
Sbjct: 2455 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2514

Query: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3383
            A +   +++  Q++ ++T  +++   TS +   T I  +++ +++ W  +       + Q
Sbjct: 2515 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2574

Query: 3384 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3426
            L   L   ++W   ++   Q  G        W      +D+++  + E+++   +LR   
Sbjct: 2575 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2634

Query: 3427 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3486
            T +  A  L  ++L   S  +T +V       H +T    +++   +R+I +R  E    
Sbjct: 2635 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2683

Query: 3487 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3523
             E+  RL Q++  DL+ F  WL + +                       E + Q+  L+G
Sbjct: 2684 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2743

Query: 3524 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3583
            +   H     +L E        Q +L S+  + + V+         R L+++   W   +
Sbjct: 2744 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2790

Query: 3584 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVS---------PRTRRQS--NRA 3632
             +    R+      ++ + +    Q++  WL+  ++++S         P  ++Q+  +RA
Sbjct: 2791 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA 2850

Query: 3633 TK-EIQLHQ--MKKWHEEVTAYRDE-----VEEVGARAQEILDE---SHVNSRMGCQATQ 3681
             K E++  +  +    E V  +  E     +E++    +E+  E    +V   +  QA +
Sbjct: 2851 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE 2910

Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
            + + ++ L L   +  + ++E ++ L+E + +
Sbjct: 2911 VNTEWEKLNLHSADWQRKIDETLERLQELQEA 2942



 Score =  167 bits (423), Expect = 4e-40
 Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)

Query: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
            E+  +L  A+  LQ      +++E  + ++     + ++  L + Q  V  I++      
Sbjct: 350  EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 407

Query: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
               KL++ EE+   +++N LN +W       + +QSN   +  +   Q+ ++ +D +   
Sbjct: 408  GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 467

Query: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
            E          +   + + E     LE LK+    +Q+ K   EDL+   Q+ +   +L 
Sbjct: 468  E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 511

Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
               +V +++S  +     LE              E+L V+  R+  +  W E++      
Sbjct: 512  HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 552

Query: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
                         LL D L     L  +Q L  + + + +  +  +     +   + LS 
Sbjct: 553  -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599

Query: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
             Q      +DL  ++++ + K  S K Q L++  +  S  Q+ E  +   ++     D+ 
Sbjct: 600  LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 654

Query: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
            V K  K+      ++ T Q  +T       E +  VT +E+  V    +EL         
Sbjct: 655  VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 705

Query: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
                + +++  +   RK    D  +   W+ +++ ++  PE  +  +         K   
Sbjct: 706  PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 765

Query: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
            I  +  E    L    R+ Q ++  +     N       SE+LN+   +F  +++   + 
Sbjct: 766  IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 825

Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
                   I    +   L ++TT + + L+ Q    S+ PT  A++  L +   C+  ++ 
Sbjct: 826  LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 879

Query: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
            ++GL   ++ L  +    +  GQ P   D      T + +      +  E+ +  + DT 
Sbjct: 880  LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 939

Query: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
               +  E M       QQ E +L      Q  V +  +  E++L    +L  SLQ+    
Sbjct: 940  PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 995

Query: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
            L  ++  +++++         K + + +  +G  K L+S + E   + E +M +    Q 
Sbjct: 996  LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1055

Query: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
             +     W+  V   L        + + +++++++ ++   ++Q+    +N+++   ++ 
Sbjct: 1056 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115

Query: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
              +A+   ++ LE  L EL+     + + +  R+  L     +     +     ++W+  
Sbjct: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175

Query: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
            A+E  +      + ++ +E  K+  E    +++      ++  L  +++ +I    P  +
Sbjct: 1176 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233

Query: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
            E L++++ +L    Q +      +   L+   A WH+     E+  + +N+ E     F 
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1288

Query: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
            L  T +     E++SE      V++S    +   E+  +Q+       T        ++ 
Sbjct: 1289 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1342

Query: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
             + T   RW  L   A  ++K+LE ++         +    E +  +  +L    A+K  
Sbjct: 1343 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1402

Query: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5303
             A++              ++ Q     L    +S L++      G+E    Q + +  D 
Sbjct: 1403 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1446

Query: 5304 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5355
                 + V    +L ++        E ++   K  + E K +L  P +E        + +
Sbjct: 1447 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1500

Query: 5356 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5415
            QL     L    +  +  +E + +  ++      T  P EL  ++  + L     +++  
Sbjct: 1501 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1557

Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5471
            K+ E +Q      +LSR+++K       +LT+  A TD  +  ++  + +   LD     
Sbjct: 1558 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1613

Query: 5472 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5521
                 K +E      K + + G+     LGK       KL+ L+   I    +AE  L+ 
Sbjct: 1614 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1673

Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
            L +   H+E +++ ++ I KWI +A  L   +       Q +E  +  + L  E  +I  
Sbjct: 1674 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1729

Query: 5582 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5638
            ++++  ++   L +    +C + +  Q++EL      +   IK    ++    K++++F 
Sbjct: 1730 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1787

Query: 5639 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5689
            ++++KL   LE   Q    L   +  +   ++     + LL   ++L+ ++      + +
Sbjct: 1788 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1847

Query: 5690 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5749
            ++ Q  L+   + +  L       + +++A  + H   Q        +   +  E+++  
Sbjct: 1848 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1902

Query: 5750 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5802
            L     ++ I+   RE++ K    + ++  QA+    +  A  ++  Q Q++      + 
Sbjct: 1903 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1961

Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5862
            K    +  +   + TV E E +   TED+  E+   PS + + +        T +S    
Sbjct: 1962 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2012

Query: 5863 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5922
            E         +++P  C              ++I      S+ R+      IH   +A+ 
Sbjct: 2013 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2063

Query: 5923 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5982
            +   P         L  L   WE +  +  ++Q     ++E+ +++   ++  +  +   
Sbjct: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2123

Query: 5983 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 6036
            E  L ++  P      +  EH      +  LQD I + Q      ++  EE++ +S + D
Sbjct: 2124 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2177

Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
             +    LQ  L  L  R   +  + S +++ LEE          Q+  L  ++ + +E  
Sbjct: 2178 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2224

Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
             WL          L P KE   ++ +L   + ++ E+  +   L +L+     +L+    
Sbjct: 2225 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2283

Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6214
             + +E ++L  KL++     +++ RAL +KQ  ++   ++  + E  ++    Q   +  
Sbjct: 2284 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2342

Query: 6215 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6271
            WL+  R     + Q  Q      +E E  +  ++  +  + S+G+ +             
Sbjct: 2343 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2390

Query: 6272 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6331
             EKP               A   ++ K E L  E+    +LLQ +  ++ +         
Sbjct: 2391 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2426

Query: 6332 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
            L  G+    G  PTQ  + VT  +     A  ++   S      S+ LE       +   
Sbjct: 2427 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2479

Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
            T L D    L           +  + +Q ++  D+++++E + K K              
Sbjct: 2480 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2519

Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6511
                                + QR  Q++E +    N +N      TS  + + II    
Sbjct: 2520 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2550

Query: 6512 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6571
                     ++IE IQ   D ++E              LQ  +  + E+ K         
Sbjct: 2551 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2580

Query: 6572 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6629
                       Q L  K + E+ L      LE+ +E   G   +    K+  E +QL   
Sbjct: 2581 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2629

Query: 6630 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6689
             +++   ++    L   L R   +   +K       + A   ++ KR  +R   LE   E
Sbjct: 2630 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2686

Query: 6690 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6740
            T   L +   +L + L  +  +  +  ++++   ++RL+       + +  +Q L+  + 
Sbjct: 2687 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2746

Query: 6741 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6796
             +    + + ++ +++L S+  SD    L+ +L+ +   W     K       LE     
Sbjct: 2747 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2806

Query: 6797 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6856
            W R      +L+ WLQ   D L     +   +  +   V+   +    F +E+  +  + 
Sbjct: 2807 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2862

Query: 6857 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6895
             S L T    L  + ++                     T  LR +   ++++W  L  + 
Sbjct: 2863 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2922

Query: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
               Q K+ +  +++L      ++ +  + L +  + K        +   ++ ++L+K K 
Sbjct: 2923 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2980

Query: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
             + +I   +  V  VN    Q+++  ++    + +   +    +N  W++LQ  V ++++
Sbjct: 2981 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3036

Query: 7016 LL 7017
             L
Sbjct: 3037 QL 3038



 Score =  162 bits (409), Expect = 2e-38
 Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)

Query: 600  EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 652
            E +S  S L E   N DRY   +  + +WL  AE  L       N  E  K  F  +  +
Sbjct: 326  EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 385

Query: 653  WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 701
             +         GN L             E    ++++Q+ LLN RW   R   ME +   
Sbjct: 386  MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 445

Query: 702  QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 754
                MD   ++  +    L+       K   EPL     ++K  +Q       DLE  + 
Sbjct: 446  HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 505

Query: 755  RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 797
            RV  +     ++ +++      + +E+ K   + +A + +  E              +LT
Sbjct: 506  RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565

Query: 798  KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
            + +  +S  L E +  +  +     K       SL K+  +   LE++ QS        Q
Sbjct: 566  EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 625

Query: 857  ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 899
            +LL+  +N   T                 +  +EK +  + + VT +       QT +  
Sbjct: 626  DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 683

Query: 900  QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
             +  +    Q +VK   +         K+ +  +S + K+ +    EL   +  ++  L+
Sbjct: 684  TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 743

Query: 952  EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 995
                PE  + R    FS L ++V NA           L+        L EQ         
Sbjct: 744  S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 799

Query: 996  GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1052
             +++A  +L+ +W +   L  E    L +    +     L  +E+  T  +   K+ P  
Sbjct: 800  SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 859

Query: 1053 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1111
             SE   IK       D+        RL  ++    +L ++       G   + L     A
Sbjct: 860  PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 913

Query: 1112 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1158
              + ++++  D    +              Y    S   +W+  +ET+L   +    D  
Sbjct: 914  FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973

Query: 1159 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1218
               +    ++ +++ + ++   L +L + +K +++ +    ++K   E  ++   +K L 
Sbjct: 974  IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033

Query: 1219 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1271
            + L E    +E+ ++       + + +K  + E+      ++E+   + D+E L    + 
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1090

Query: 1272 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1331
             +LL+   Q  +       +  Q+I    + E     R   EL++L +  D + +    +
Sbjct: 1091 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1148

Query: 1332 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1391
            +  ++  L K    + +   +  ++ Q   + E +L          EL++  E  KR + 
Sbjct: 1149 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1205

Query: 1392 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1445
             A Q E  VK  +E          P  ++ L+++ +++    + L   L    KT+E V 
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265

Query: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1505
              W    S  E  + W+ E E +L   E      +    +I   +  +E+ +        
Sbjct: 1266 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1321

Query: 1506 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563
            + +  AQ +T G      I  +L        EL E A   +  +   +   Q+ E++L  
Sbjct: 1322 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381

Query: 1564 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1606
            IQ+S++  + +LA  I              KI S  T    + + +++H    +A + + 
Sbjct: 1382 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1441

Query: 1607 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1663
            S I       + V  +    Q+ A  +Q+ ++   IL   K    ALE      + ++ +
Sbjct: 1442 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1501

Query: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
            L+  +   +      S  EM I   R       Q++Q  Q E   +              
Sbjct: 1502 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1542

Query: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
                  + V  +KLH  +L  +  +  Q + K +   + +  E     E       W+  
Sbjct: 1543 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1589

Query: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
               EL   S +  M   +         A  ++ + E++  + HL  +  +G A  L  + 
Sbjct: 1590 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1642

Query: 1844 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1901
            GK E    L E+   ++    +A+ S   E+L         +    Q V+  T  + + +
Sbjct: 1643 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1699

Query: 1902 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1961
            + L E +     Q    L+     L+ I  K        + +Q  +  A     C     
Sbjct: 1700 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1749

Query: 1962 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2019
             + L+  + SE +   A +    +  K  + LK +E     +D ++L EP    +QQ + 
Sbjct: 1750 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1806

Query: 2020 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2073
            +    FN  +D    +E  +  L  +   + Q+  D     E+  +   L+   +  K L
Sbjct: 1807 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1864

Query: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
              + + +   +     +Y+     + K L++    + +    +D+  +K    + +  K 
Sbjct: 1865 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1924

Query: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2177
            ++N  ++  +  +  G  +  E  +I  S                +F+ + T  E T+  
Sbjct: 1925 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1982

Query: 2178 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2236
             + ++E +   +  +    L+    V     E+E   N   P +     + ++  + EE 
Sbjct: 1983 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2037

Query: 2237 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2296
            LK  +  ++  + R++ +HSK    K       TP +   ++  L Q     +++ ++ K
Sbjct: 2038 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2093

Query: 2297 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2350
                 F     +  +F  DI     W T+ E+ L      E  E  K    +K++Q  + 
Sbjct: 2094 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2153

Query: 2351 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2408
             +Q+ + +       + ++    +   L   +  L ++  E   QL   K +   Q+++ 
Sbjct: 2154 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2213

Query: 2409 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2468
              F   + EF  W   A   A    +  G  + L+ KL  ++ +++ +   Q  L  + +
Sbjct: 2214 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2272

Query: 2469 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
             G  +   A +S +    ++ ++ + N        Q +K  +AL +   E+ +       
Sbjct: 2273 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2318

Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
                          ++LG+ ++ + + + +++ + ++L  +    E  ++ +Q G    +
Sbjct: 2319 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2366

Query: 2587 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2642
            E   A Q  +    ++L+  Q+L +    T+   R  +    E +A+   LQ +    +A
Sbjct: 2367 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2422

Query: 2643 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2700
             Q  LA   +T+G+  T  + ++ +   ++ K     KL M  ++     AL   N+   
Sbjct: 2423 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2480

Query: 2701 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2760
             +           W  ++   + +Q  +   +   N+ + ++    Q +E          
Sbjct: 2481 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2521

Query: 2761 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2820
            Q +P L+E      +L++  S  E  T    R+                     E ++ Q
Sbjct: 2522 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2560

Query: 2821 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2880
            ++++    + + +++ E++KD   +L+A  E    L  A+ +L  W +      A QKK+
Sbjct: 2561 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2620

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
            ++ K+L        + +     LA ++ ++ +A     +H   + + A W+     V + 
Sbjct: 2621 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2680

Query: 2941 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 2997
            ++ LE    L+ Q  L  ++F   +A L +A E  + +L+   ++  LLE     +E+++
Sbjct: 2681 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2736

Query: 2998 CWHKGQEILDA 3008
             W   Q  ++A
Sbjct: 2737 QWQDLQGEIEA 2747



 Score =  159 bits (402), Expect = 1e-37
 Identities = 533/2914 (18%), Positives = 1109/2914 (38%), Gaps = 456/2914 (15%)

Query: 3061 KEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3120
            + ++   R++ A  +   WL++A+ T     +I  ++  V       + ++ +    Q +
Sbjct: 336  ESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGR 395

Query: 3121 LNMMLSKGELL--STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
            +  +L  G  L  +  L++++   +Q ++      W+       +K+S L  + + +++ 
Sbjct: 396  VGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQ 455

Query: 3179 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3236
            ++  + + DWL+KTE+   +        DL   +R+ Q+ + + E++   + ++N L   
Sbjct: 456  KL--KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513

Query: 3237 AQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEK-------VSRLDRIVAEHNQFSL 3287
               + E  G  A+ +   ++  L  ++  +   T+++       + +  R+  E   FS 
Sbjct: 514  VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 573

Query: 3288 GIKELQDWMT--------DAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE--KEIQM 3337
             + E +D +         D   ML S       K+ L+ +   +  L S+KQ+    ++ 
Sbjct: 574  WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633

Query: 3338 KMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA--GIRCKSQLEGALSKWTSYQ 3395
            K +  + E+ L N +      +Q+  +S   +  ++ +    +   + +E   +  T  Q
Sbjct: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 693

Query: 3396 DGVRQFSGWMDSMEANLNESERQHAELRDKT----TMLGKAKLLNEEVL----------- 3440
              V+     +              +E+R +     T L      +E VL           
Sbjct: 694  ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 753

Query: 3441 -SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQER-------AKEAVTKSEKLVR 3492
             ++S L E +        E +    +LQD     +A+ E+       A      SE+L  
Sbjct: 754  GNFSDLKEKVNAIEREKAEKF---RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS 810

Query: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
               E+ + L     WL  +   +  Y+ L+       TT  +  ++Q         + S 
Sbjct: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQ-QLEQMTTTAENWLKIQPTTPSEPTAIKSQ 869

Query: 3553 LHTREDVIP--SGI-PQAEDRALESL-----------------------RQDWQAYQHRL 3586
            L   +D +   SG+ PQ E   ++S+                       +Q +   Q R 
Sbjct: 870  LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQARE 929

Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
             E +T F+ +   +R  E     +  W++ +E K+S      ++    E +L +++    
Sbjct: 930  KELQTIFDTLP-PMRYQET-MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 987

Query: 3647 EVTAYRDEVEEVGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3704
             +   +  +  +    +E+  +  S ++ +   +  ++  R++ L  Q++E  + LEE++
Sbjct: 988  SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1047

Query: 3705 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3764
              L + ++ + +   W        K     +   D+ ++ K+LK   +L+ D++     L
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG--DSEILKKQLKQCRLLVSDIQTIQPSL 1105

Query: 3765 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTV--RKEHMT--LEKGLHLAKE 3820
             S  E G++     E   A RL  E+ +   Q   +   V  RKE +   LEK + L K+
Sbjct: 1106 NSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKD 1165

Query: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
             S+  + +TQ   EY E     + P     E +  + + K  ++     E  VK + E  
Sbjct: 1166 LSEMHEWMTQAEEEYLERDFEYKTPD----ELQKAVEEMKRAKEEAQQKEAKVKLLTESV 1221

Query: 3881 EALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW 3937
             +++     V    LK +++ L ++YQ LC+       +LE       +  S L++  KW
Sbjct: 1222 NSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKW 1281

Query: 3938 LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI-GQCAD 3996
            L ++  +L   + +   + E I++ L   + +M      ED  N +++   TL  G   D
Sbjct: 1282 LNEVEFKLKTTENIPGGA-EEISEVLDSLENLMRHS---EDNPNQIRILAQTLTDGGVMD 1337

Query: 3997 HL----------------------QAKLKQNVHAHLQGTKD----------------SYS 4018
             L                      Q  L+Q++ +  +  K                 +Y 
Sbjct: 1338 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1397

Query: 4019 AICSTAQRMYQSLE-------------HELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-- 4063
            A    A +M Q  +              E++KH   ++  Q+  + +   Q  L+     
Sbjct: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457

Query: 4064 ----QPPLSRAEAIKQVK--------HFRAL------QEQARTYLDLLCSMCDLSNASVK 4105
                Q P +  + +++ K        H  AL      QE  ++ L+  C     S + VK
Sbjct: 1458 FRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH-CVNLYKSLSEVK 1516

Query: 4106 TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RH 4160
            +  + + +T + I QK  Q +N  +  E +  LK   +EL   + +  QQL+   +  R 
Sbjct: 1517 SEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575

Query: 4161 SELELNIAQNMV----------SQVKDFVKKLQSKQA-----------------SVNTII 4193
               E+N+    +          S V+     L S+ A                 S+  + 
Sbjct: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1635

Query: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVE 4250
            E +  +  K+E+    +++ LN  W+ +  ++    NL L+ ++ ++      D      
Sbjct: 1636 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD------ 1689

Query: 4251 VFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
              + K+  + D L   S+ +      + LK+L   L + +  ++  +DQ   ++ +    
Sbjct: 1690 -HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1748

Query: 4310 DKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIA 4368
             ++LV+ Q S L  R+  +   IK  K  + +  LE+ N    +  E +E   +Q  N+ 
Sbjct: 1749 CRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1808

Query: 4369 EALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALS 4428
            E        D  +++  D+     EL  +   L+  I D           +R+ I+    
Sbjct: 1809 EE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQ 1852

Query: 4429 DAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD 4488
              Q+  N L DL  QRRK   KAL    Q+     QA   ++  +      + +  LP+ 
Sbjct: 1853 LLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEP 1906

Query: 4489 -----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
                 + +  +  +  +  L   + +  GL   G  +  E T+ + S+   +++   + +
Sbjct: 1907 RDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 1966

Query: 4544 DSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLM 4592
              +     H ++E           LE + V   +  E    +   L+   ++  P++   
Sbjct: 1967 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CA 2025

Query: 4593 NESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQF 4652
             +  +L  Q    +NI +   +    +  +       L S   V+   L E L+ L  Q+
Sbjct: 2026 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQW 2085

Query: 4653 NVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE---- 4708
              +  + KD+  +   ++   + +   I++  Q L+E E QFLR +++P +    +    
Sbjct: 2086 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWY 2144

Query: 4709 ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQ 4768
               LQDG       V  L    +E+ Q+      T      +K+  L   +  + +Q   
Sbjct: 2145 LKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSD 2201

Query: 4769 RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4828
            R   LE+  +   E ++   +    L+         N  ++P E          G  Q  
Sbjct: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQL 2246

Query: 4829 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4888
               L++V + +E+L     PL  +    Q+    G + +      E   + E+++ Q+  
Sbjct: 2247 KEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2300

Query: 4889 FQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK 4947
               ++SR+L   +  ++A++     L+  L+D++E++  + +    +++ L I N  +  
Sbjct: 2301 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ- 2359

Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQA 5004
                                    E   D+QE   A++ +Q  + EI S+ Q  Y+    
Sbjct: 2360 ------------------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--- 2392

Query: 5005 ANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLI 5063
                                 + A + +K  +E  S+E    +  L+EL +    L P +
Sbjct: 2393 ---------------------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2431

Query: 5064 KPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5117
               G    +      Q V + E    ++   S   +++         D+ +A  E+ + +
Sbjct: 2432 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWL 2486

Query: 5118 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDA 5176
            +  ++ +    ++      +  E + + KA +  +     ++  L   A  L+ KT N  
Sbjct: 2487 SLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 2545

Query: 5177 SKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5236
            ++  ++  +  +  +W  ++   Q++ + L + + + T +    ++A +++ Q + KL  
Sbjct: 2546 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 2605

Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
                  +   +   +        +L Q Q+ + +     L +L+D +A    ++   +  
Sbjct: 2606 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHM 2661

Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
            IT          E +  + + + + + +RE            ++ET   L     +    
Sbjct: 2662 IT----------ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLD 2697

Query: 5357 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQD 5415
            LE+    LTEA      ++    +++                 L E +  +K +  Q QD
Sbjct: 2698 LEKFLAWLTEAETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQD 2740

Query: 5416 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSK 5475
               E+E        L    QK+ + L               +   D  +L   LD  N K
Sbjct: 2741 LQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFK 2785

Query: 5476 LMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5532
              EL      ++  LE +    K L   + +L  +  Q      +R + +      +++ 
Sbjct: 2786 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQ 2844

Query: 5533 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKL 5590
            N++     + ++  + +   T+         +     + L +E +E+  E  A  +T  L
Sbjct: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2904

Query: 5591 QYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK--- 5643
            +       T  EK++   A+  R+ +E  +    RLQ LQ+A    D+K  +AE+ K   
Sbjct: 2905 RKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSW 2960

Query: 5644 ----------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
                      LQ  LE+ +A       G ++ LKE +SH   L  ++ +L      +QL 
Sbjct: 2961 QPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLS 3010

Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5726
               L   ED+     L   A+   E+  R  H A
Sbjct: 3011 PYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3041



 Score =  157 bits (397), Expect = 4e-37
 Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)

Query: 5520 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5577
            S L ++  +L+ Y   LE +L W+  A+  + A G I+ N    +++Q+  H+  +    
Sbjct: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 387

Query: 5578 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5636
            ++ +    +   LQ  + +  T K+S+       E +E   ++  R + L+ A+ + +  
Sbjct: 388  DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 444

Query: 5637 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5695
                L  LQ   L++    LT  E     ++E+      L  ++E LK +VQ  ++ Q  
Sbjct: 445  LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 499

Query: 5696 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5755
            L   ++ V    L H  + + E +      A+                E+++K L     
Sbjct: 500  LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 541

Query: 5756 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5802
               R  ED+ V   +I    Q L        A +S  E+   KI   G+++Q   L+S  
Sbjct: 542  NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 601

Query: 5803 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5856
            K+  +KA       ++ ++  L +       +LL T   + SV   T        RC   
Sbjct: 602  KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 653

Query: 5857 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5916
            L    E+S      ++IS       PS    T       +   + +  +  Q +     P
Sbjct: 654  LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 707

Query: 5917 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5976
                 Q   +  +       + +L  SW T    + +     +    ++  + D    + 
Sbjct: 708  PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 760

Query: 5977 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 6036
             K+ AIE + +E                    +   LQD     Q+ L E++V+E   AD
Sbjct: 761  EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 799

Query: 6037 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6096
              +Q + Q            +  +     QLL E+LN  LE Q    A      +  +L+
Sbjct: 800  SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 843

Query: 6097 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6156
                + +  L    + P EP  +++QL  C++ +  +      +  L + +  L  +G+ 
Sbjct: 844  QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 903

Query: 6157 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6216
                +A+ +A                 H KQ+     A+EKE   +    T  P   +  
Sbjct: 904  PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 947

Query: 6217 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6264
              A  TW QQ ++ L          + +EQ L E ++L  S+  +   +      ++  +
Sbjct: 948  MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1007

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6295
             +   +   K     +E+    +K S+         E+QM                    
Sbjct: 1008 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1067

Query: 6296 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6351
                + +W +L      K++L Q  L     Q +    N +  G    K +   +  S +
Sbjct: 1068 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1127

Query: 6352 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6406
             + L  LN  ++ +  Q    K   +  +     L   +S    W+   EE         
Sbjct: 1128 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1187

Query: 6407 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6462
              P+E +  +   +   ++ ++   ++    +   ++ +QA P     ++ ++  L  L 
Sbjct: 1188 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1244

Query: 6463 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6506
                 L + +N +C          H++   L++   + N+++    +       A+    
Sbjct: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304

Query: 6507 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6564
            +L  L N+    +    QI  + Q        D G+++           +   +EL    
Sbjct: 1305 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1348

Query: 6565 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6624
              + EL      R+  L Q++    + E++L  + + L    +++A      ++ K +  
Sbjct: 1349 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1404

Query: 6625 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6684
            Q+  + ++    L SH I  E + +        +  +    +++Q     K+     ++ 
Sbjct: 1405 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1458

Query: 6685 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6744
              + +  ++ ++  QE    L+ V+  +P++      ++ +  ++    +L  SL+E + 
Sbjct: 1459 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517

Query: 6745 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6801
            ++  V+  G++++         +L+ ++  L   +     K+++   +LE  LK   + +
Sbjct: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577

Query: 6802 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6857
             E   L  WL +        T   +T    +E +  +L++ + + K    E++ Q     
Sbjct: 1578 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1629

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
            S+   G  L  +       +  +LS ++S W  + +        L + Q         + 
Sbjct: 1630 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1689

Query: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6977
             +  WI   + ++ + E         K   +     K  K ++N  +  VD        +
Sbjct: 1690 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1741

Query: 6978 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 7036
             +   +  R        Q+  +N  +  +   + T K  +    L+   ++ +++Q L  
Sbjct: 1742 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1795

Query: 7037 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7087
              E +        E+   +     ++ +V+  L+   +L+  I  + K  E KI+Q  L 
Sbjct: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855

Query: 7088 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7142
               N  +D+ S       E+   W         L   L  +  + +S     D+     I
Sbjct: 1856 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1915

Query: 7143 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7197
            +  L + +  L+  R     L     A+ V+   +Q     L K+ R ++ KF       
Sbjct: 1916 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1970

Query: 7198 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7256
              + H    ET+    +++ +  + +    + E    S+ALL++ Q              
Sbjct: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2019

Query: 7257 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7316
                              A D  A   +D     + L  +KDSL       + +  +  A
Sbjct: 2020 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061

Query: 7317 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7369
            +  SA   +++ L + L  L+    K       +Q      V  +  F   ++    W+ 
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121

Query: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7427
            EAE+ L+      + + +  +  ++EL+  + +  ++   L+   E +  +    D  I 
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2181

Query: 7428 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7483
             +++ +LN  W  +  Q ++R  +L+   + L + Q  L +   W+E   + +   ++ +
Sbjct: 2182 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2238

Query: 7484 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7540
              G  Q L E+    +L   E+  RQ IL  +   G  +L    +  +++D+   KL   
Sbjct: 2239 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298

Query: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
            + QW  V R   +++G I++QI+   +  +  E L + L  +          + I  Q  
Sbjct: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2358

Query: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7660
            +    +VQ  E     +Q      +  G+ L    +  A   ++ +L ++  +WK+ +  
Sbjct: 2359 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2416

Query: 7661 LEEQKKKLAFL--------------------------------------------LKDWE 7676
            L+E + K   L                                            L D+ 
Sbjct: 2417 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2476

Query: 7677 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
            +    + D L  L    K    +   L D +E +  ++   ++LE       + +T    
Sbjct: 2477 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2536

Query: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
            LK+  S   + +  +I+ +R+E +Q QW+E+   L  RRQQ+ E L +   + E  +E  
Sbjct: 2537 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2593

Query: 7794 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7849
            + L Q  +K+   + G   ++ + +K+   K   +++   Q N      +  +L +    
Sbjct: 2594 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2653

Query: 7850 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7909
                ++      +N  W+ +   ++ R   L+ET   +QQ   ++     WL   E+E  
Sbjct: 2654 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2711

Query: 7910 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7962
              ++ D+   E        ++  + + Q+LQ +IE H+    ++    + +L   +  + 
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2770

Query: 7963 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 8022
            DA    +Q+   N++ +W  +   S+  R  +E +   W++          WL+  +   
Sbjct: 2771 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2828

Query: 8023 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 8063
            +  +  G  +   +++     AF+R++                    + L  LE + ++ 
Sbjct: 2829 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2888

Query: 8064 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8122
            R L  E R  +    L++   E N  W+ L        R++   + + +E + A D    
Sbjct: 2889 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2944

Query: 8123 WLTEMDLQLTNIE 8135
               E+DL+L   E
Sbjct: 2945 ---ELDLKLRQAE 2954



 Score =  142 bits (359), Expect = 1e-32
 Identities = 456/2427 (18%), Positives = 928/2427 (38%), Gaps = 370/2427 (15%)

Query: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
            + TKE   QLH    + +++T +     E   +        ++  +     +    S + 
Sbjct: 259  KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 318

Query: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
            +  L+  E   F    +E E+ +L+  +++L     W  S     +      + V+ V  
Sbjct: 319  SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 376

Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
              +  T E  + D+      + +  + G + +   +  E E    E+ + M  L      
Sbjct: 377  -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 433

Query: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
            +R   M  +  LH  L    + K K L  W+ + +E     EE  +  +L + K Q+ ++
Sbjct: 434  LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 493

Query: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
            K LQ+ +   +  V S+            +   A LE                      L
Sbjct: 494  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553

Query: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
            +QD+ LK  ++ + Q  +    S  ++ V  +     KD  +  S LQ       ++EK 
Sbjct: 554  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612

Query: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
              Q  G+L +   DLL T   +++TQ+    +A ++  A   D L     K    I Q  
Sbjct: 613  KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 669

Query: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
               Q  L Q          ++ + + +  Q + +  + EL        RQ T+       
Sbjct: 670  TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723

Query: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
                  +  +W++  +  L+ SP+  + R E           AI++ K   FR LQ+ +R
Sbjct: 724  LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 782

Query: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
            +   L+  M +         A  I+Q  + +  + ++   L      W E ++     + 
Sbjct: 783  SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 837

Query: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
             LQ  +Q     +     +  +  E    ++ +   KD V +L   Q  +  +  +   L
Sbjct: 838  QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 897

Query: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
             +K + P   +       NH    + D+  Q+    LQ   D      Y + M+ +  ++
Sbjct: 898  KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 955

Query: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
            ++  T+     L+ +D E     L  L+ L  +LQE++  +  L    ++M +    +  
Sbjct: 956  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015

Query: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
               + +   +E RW +L   +    Q     + +L  +Q+  Q L +W  E    + E  
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075

Query: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
                  ++ +  L     + S+++  Q  L S+ +   ++  +        ++  L +  
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135

Query: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
            +  + +   V  R++ L   L +       + +    + Q E + + R+     PD++ K
Sbjct: 1136 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1195

Query: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
             V+  K A       +A +K     V  + AQ   + +E  ++E       L+ L + Y 
Sbjct: 1196 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1248

Query: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
             +  + + + + LE+            +KA  WL + +       N+   + E+   L  
Sbjct: 1249 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1308

Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
             +N++  S +  N +  L +T           D   + E +N     FN        ++ 
Sbjct: 1309 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1352

Query: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
            ++ E  + R++   L+E + QS  E E              ++E+L+  D   A     A
Sbjct: 1353 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1395

Query: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
             + + VD     +E      Q  Q D   H ++L                      ++H 
Sbjct: 1396 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1431

Query: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
            +  +  +R L  +   Q K+ + ++    K +++   A     LQ+S ++L  V +HL  
Sbjct: 1432 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1485

Query: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
              P L+  + E  +  +QS       L  ++ E  +E E       ++VQ    QTE  +
Sbjct: 1486 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1539

Query: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
             LD   RV A       L L+  ++     K+   +++++  L++   +    KE     
Sbjct: 1540 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1584

Query: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
            + L + D+E  L + S ++G   ++   +   +AT  EI  Q    +   +V +A    L
Sbjct: 1585 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1642

Query: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
               + L++     L  N + V S AEE L   +E+    + F  N++ +   +   D L+
Sbjct: 1643 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1702

Query: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
                  KP  KED+ +++ + EL   R   DS    D      A   D+ +K  E  I  
Sbjct: 1703 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1759

Query: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
            +N     +S    +KT  +     E E+  S+ + L+  + +  ++ V L+E+     K 
Sbjct: 1760 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1815

Query: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILE------------------DA 5209
             N+ ++ T+   +     + QR T  R R   + ++++L+                  + 
Sbjct: 1816 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1875

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
              +W  +  +     + +D ++ KL  S  E   + ++  +         EL++++  L 
Sbjct: 1876 SHQWYQYKRQADDLLKCLDDIEKKL-ASLPEPRDERKIKEIDR-------ELQKKKEELN 1927

Query: 5270 MLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQE 5321
             +R+Q   + +DGAA    PT  +     +EI +   Q R LN  +   V+    +V  E
Sbjct: 1928 AVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTE 1987

Query: 5322 LKDREM------VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQ 5372
                E+        T+I  V   + E ++ L  P +   + +   ++ + L     + +Q
Sbjct: 1988 DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQ 2047

Query: 5373 NIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQ 5428
            +  ++     +K   L +  P E + LQ A   LD    K+    +D+    ++S    +
Sbjct: 2048 SSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2107

Query: 5429 ELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAA 5482
                 I K+     T   +   KT   +N   AK  +  L E  DG   +   +  L+A 
Sbjct: 2108 RFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNAT 2165

Query: 5483 VQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILK 5541
             ++ ++Q+ +     L +K+G L    Q+  +Q  +R  +L +  + L E+   L   + 
Sbjct: 2166 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2225

Query: 5542 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSV 5596
            W+E+A  +A   +      QL+E+    + L+EE       L+ + E      +    S 
Sbjct: 2226 WLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISP 2285

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE------- 5649
               +K+  ++ +   +  ++ + +  +   ++   KD+ + E +L+ L+  L        
Sbjct: 2286 EEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2345

Query: 5650 ------------------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MES 5681
                                Q T  + +  +  ++E LS  QHL  E          +E 
Sbjct: 2346 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2405

Query: 5682 LKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAA 5736
            L  + +AV      LR  + D+   L    A+    + L  +    + TAI +  +  + 
Sbjct: 2406 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSL 2465

Query: 5737 VVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQE 5793
            +++      + +    L   +    + I+ + V   +++++   I + +   Q ++  + 
Sbjct: 2466 MLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP 2525

Query: 5794 QIASLNSKCKMLTMKAKHATMLLTVTE 5820
            Q+  L +  + L  K  +      +T+
Sbjct: 2526 QLEELITAAQNLKNKTSNQEARTIITD 2552



 Score =  134 bits (337), Expect = 4e-30
 Identities = 262/1425 (18%), Positives = 568/1425 (39%), Gaps = 225/1425 (15%)

Query: 7330 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7389
            SQHL A E       +SL    ++ + +  +LE + +W++ AE+ LQ Q    S+D+  +
Sbjct: 319  SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 375

Query: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7441
            +++    +G M+  ++    +  + +LG +L    K       E++   NL N  W  + 
Sbjct: 376  KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435

Query: 7442 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7499
              + E+ S L   L+  Q   L++   W+    +  +K+  E  G + + L  Q + H++
Sbjct: 436  VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495

Query: 7500 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
             Q ++   Q     + H +++  +   +       ++    L +L ++W  + R  + R 
Sbjct: 496  LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 551

Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
             ++   + +WQR  E       WL E                       D V        
Sbjct: 552  VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 590

Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
            + Q   + +++  K  +L AD   +     +L  +++   S +++ +   +K    L ++
Sbjct: 591  KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 647

Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
             +C   +   LEK                           ++  AV +    LTQ +++ 
Sbjct: 648  ARCWDNLVQKLEKSTA------------------------QISQAVTTTQPSLTQTTVM- 682

Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
            +T++   + + I        L++   EEL      +++QI        V SE  K L   
Sbjct: 683  ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 727

Query: 7796 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQEN--KIQLQQMGERLAKAS 7847
            +T++ S ++++  +L        +K     D +E++ AI +E   K +  Q   R A+A 
Sbjct: 728  ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 787

Query: 7848 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKLK--ETLVA----VQQLDKNMS 7895
             E   +E      I+    ++N RW     L++ R+  L+    ++A    +QQL++  +
Sbjct: 788  VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847

Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
            +   WL    +  ++P    S   +  + ++N    LQ  IE+        L +  + L 
Sbjct: 848  TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 898

Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 8015
            +        + D +   T +  + + ++ A   E +   +    +  ++ +  S    W+
Sbjct: 899  EKGQGPMFLDADFVA-FTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 955

Query: 8016 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8075
            + SE   + P  S   Y + ++ L + +A Q  + E  + L  ++   + ++++  ++ +
Sbjct: 956  QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015

Query: 8076 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI- 8134
               +    E   RW  L  ++    ++L+  + +  + +    ++  W+ E+D+ L    
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075

Query: 8135 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8193
                + ++  K +KQ +    +I      +  +   G+++  ++EP  A+ +E EL EL 
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135

Query: 8194 ----RYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 8248
                  CQ+V+ R E     L + + L  D  ++ +   + E+     D  +        
Sbjct: 1136 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-------- 1187

Query: 8249 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8308
               +    L  ++ +  R++   +   A V            L+  + S +++A P   E
Sbjct: 1188 ---KTPDELQKAVEEMKRAKEEAQQKEAKVKL----------LTESVNSVIAQAPPVAQE 1234

Query: 8309 EGQDDKDF----YLRGAVGLSGDHSALE----------SQIRQLGKALDDSRFQIQQTEN 8354
              + + +     Y      L+G    LE          S + +  K L++  F+++ TEN
Sbjct: 1235 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1294

Query: 8355 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQT 8414
            I     P G E             E S  +DS   LE+ ++  E++ P  + + +     
Sbjct: 1295 I-----PGGAE-------------EISEVLDS---LENLMRHSEDN-PNQIRILAQTLTD 1332

Query: 8415 AGVID------------RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8462
             GV+D            RW  L  +A+ ++  ++Q++Q  Q+              TE+ 
Sbjct: 1333 GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE--------------TEKS 1378

Query: 8463 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQD 8522
            L  +Q      D Q       K+   Q   + +K   +  +L S E +  + K+    ++
Sbjct: 1379 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMKKHNQGKE 1435

Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN---IDRRKNEIVPI 8579
                      RV S ++  +  LQD  M+ + F + ++    + E+   +D  K  +  +
Sbjct: 1436 AAQ-------RVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPAL 1488

Query: 8580 DS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVI 8638
            ++ +++ E++Q      + +   L E +  V  +     Q++   +  +  E  E+V  +
Sbjct: 1489 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTAL 1548

Query: 8639 GNRLKLLLKEVSRHIKELEKLLDVSSSQQD----LSSWSSADELD 8679
                  L  +V+   ++LEK L +S   +     L+ W +A +++
Sbjct: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593



 Score =  119 bits (298), Expect = 1e-25
 Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)

Query: 521  SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
            S +++W+ +   + S+ QL       +E          S   EQ    Y +     EM  
Sbjct: 949  SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1008

Query: 572  KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
            KA   +  +        E   +W+ LS ++      LEE ++   +  N + +L+ W+ +
Sbjct: 1009 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066

Query: 632  AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
             +  L +       SE  KK     R L   IQ       ++N+ G  +    +   +  
Sbjct: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1126

Query: 679  LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
            L+ +L  LN +W  +  +V  YA+ + +    K   +  V+L    +E H+ ++    E 
Sbjct: 1127 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180

Query: 735  LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
            LE  F       ++  +++++  ++     +A+ K++T++ + +  ++P           
Sbjct: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1233

Query: 790  SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
              LK++L  +   Y  L          LEE+          L K N+ +  +E       
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1286

Query: 850  LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
             FK K             T   I  G++ + + + +L N+++H +    Q +I    +  
Sbjct: 1287 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1332

Query: 909  QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
              ++ +  +  + +ET +   ++  E     +K+L   ++ ++   + E+ L    E  +
Sbjct: 1333 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1387

Query: 969  QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
             +D++ L A++   D++      QE Q +Q  +      L +  K  QG+     +  +I
Sbjct: 1388 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1444

Query: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
            DV + +          ++  + +L  +  + E+ ++E ++   D+   HL     + +E+
Sbjct: 1445 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1495

Query: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
              V+  +   V       + +L E+++ ++   +        K  E+P +  +  +    
Sbjct: 1496 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1550

Query: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
             ++E  + ++  + QL+  K   +      E+    E +      +TKR   +  + S L
Sbjct: 1551 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1607

Query: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
              +V    +++ E +KQ   L  ++   +AL T+L + E ++ +    +    I V +  
Sbjct: 1608 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1667

Query: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
            EE ++   E Q+  E         T+ + +A  LL   ++K         KR+ A+  D+
Sbjct: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1727

Query: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
            + ++   +     L     +  RKL        +  E   R   ++     R +T K ++
Sbjct: 1728 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1778

Query: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
             ++ L Q  S  ++ L     E L +E++Q     +   +  +  +N       +  G  
Sbjct: 1779 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833

Query: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
             +Q +  + K     IK+Q+ + +    +D+++    K      +W  +    + L   +
Sbjct: 1834 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1893

Query: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
             + EK+L +L       + +I +I   +Q+ + +L+++     GL E+  + A    Q  
Sbjct: 1894 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1951

Query: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
             +     I++K  Q RR        +RE    +  E   L        +   +  + Q++
Sbjct: 1952 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2011

Query: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
             E E  L  P        + +K  +   ++  +L+  S  I       TA   SA  V  
Sbjct: 2012 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2070

Query: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
            R    +  + L  Q+E + +  K+RQ   +  +  W+R   ++  F  WL   E      
Sbjct: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2130

Query: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
            ++  + +  K +  L   + LQ+ +  + +    L    E +   +SK D  +++  L  
Sbjct: 2131 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2187

Query: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
            L+ RW+++ + ++ R   L+       +F   L  F +W    L E    + I +   + 
Sbjct: 2188 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2243

Query: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
               + K+   +V+    EL   QG L +L   G           E+   L+ K +     
Sbjct: 2244 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2301

Query: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
            + + S+ +  +Q  + + + +  Q    L  +  QL   +   + + +N+ ++  +    
Sbjct: 2302 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2360

Query: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
               D  +   A+++    ++ ILSK Q+  K   + Q    +   + L  E + +  LL 
Sbjct: 2361 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2418

Query: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
              +++   LA           + +  +    + + T   +L+ P+   L+   L  FN+ 
Sbjct: 2419 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2478

Query: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
              EL        WL     Q+ +       +++ +IN + +    T + + + + Q   L
Sbjct: 2479 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2527

Query: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
             +L+   QNLK+  S   + A ++I  R                E  +N+ +  Q+ L N
Sbjct: 2528 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2570

Query: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
                 +  L+E+ K             +ST  +WL+  E+ E+ + + R  L  W +   
Sbjct: 2571 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2611

Query: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
            T D I+        Q+A+++    +N+D  N L A +LL+++ ++   K   + E     
Sbjct: 2612 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2669

Query: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
               +H +V++ +   +  ET   LQ    DL + L    E  E     L+D    +T+ E
Sbjct: 2670 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2722

Query: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
            + + D                     E +K+ +D+Q E+++      +  EN   + R  
Sbjct: 2723 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2766

Query: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
              S +   L R +  +  K   + +     ++ L+ S +  K    S+QE   W      
Sbjct: 2767 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2826

Query: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
                   +G    A  K++       + L+ K   + + L++V           L+ + Q
Sbjct: 2827 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2886

Query: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            E + L      Q V+  +++Q  + N E++         ++ + +    L   ++   +L
Sbjct: 2887 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2946

Query: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
            +L + + E  + + + +G+    I   ++ + KV+   GE+   +E++  ++   + L+ 
Sbjct: 2947 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3004

Query: 2587 EG 2588
             G
Sbjct: 3005 LG 3006



 Score =  114 bits (286), Expect = 3e-24
 Identities = 347/2017 (17%), Positives = 774/2017 (38%), Gaps = 287/2017 (14%)

Query: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
            Y + L+EV  WLL     L A   + ++ +E +  Q   H+  M ++   + R+ N+   
Sbjct: 344  YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 402

Query: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
            G  LIG        KL ++    +Q   +  ++       A    QS  H +   +  Q 
Sbjct: 403  GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 456

Query: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
             L++   WL+  +       + PL     +  +QV+  + LQE      DL      +++
Sbjct: 457  -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 509

Query: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
             +      D    +        Q + L   W  I     + W+ LQD   + Q +     
Sbjct: 510  LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 566

Query: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
              E  +    +S+ +D V K+ +      N ++  + KL   +   E K           
Sbjct: 567  --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 613

Query: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
              +QS       ++DL  T          E +L+ F   WDNL +   +STA   +A+  
Sbjct: 614  --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671

Query: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
               +L +      +  +  ++Q +++H     +EL        ++R   ++  I++++ V
Sbjct: 672  TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 726

Query: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
             +T             EL  W        +EA+ QSP     +  +       S+L+ K 
Sbjct: 727  DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 763

Query: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
              ++    +  R + D   + + ++++ +++  +     +D + Q  + LN       + 
Sbjct: 764  NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 818

Query: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
            LSE+  +L     +    +Q+QQ E+     E+   +       P  +  Q+K CK    
Sbjct: 819  LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 878

Query: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
             L   Q ++  L  Q   L ++                  +Q  S+V  + +ELQ+++D+
Sbjct: 879  RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 938

Query: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
            +                    ++E       W++Q++  ++ P++++  +   +  +L +
Sbjct: 939  L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 981

Query: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
             Q +     E ++ L  L  T + +     +E+   Y SE    +  ++  + +   +  
Sbjct: 982  LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1040

Query: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
             K++E +   ++  + I+   + ++E++  FL+  + P  L   E L  Q   CR ++ +
Sbjct: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1097

Query: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLVTLYHR---LKRQ 4765
            +  +  +++ +N+  +  ++  +P               Q D M   V  Y R   LK  
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQV--YARKEALKGG 1155

Query: 4766 TEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL 4825
             E+ VSL +D +   + HE M Q  E  L+  ++ + K  +E   A E++K     A   
Sbjct: 1156 LEKTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA--- 1207

Query: 4826 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4885
            Q     +K +T  +  +     P+A E  + ++++     + L + +       E     
Sbjct: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267

Query: 4886 SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMN 4942
              +  + + ++  WL  V+ +L     +    ++I E    +  +  H E+  + +RI  
Sbjct: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI-- 1325

Query: 4943 ALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVF 5002
                                L  +L +   +D  I E L T  +   E++ +  R  ++ 
Sbjct: 1326 --------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1365

Query: 5003 QAANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 5060
            + +    ++ ++ L L    L    +     +   ++      +      +L S   +L+
Sbjct: 1366 EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLE 1425

Query: 5061 PLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELM 5117
             + K    ++  Q+V S    +Q+  +D   +  L Q+        Q+++   +EV   +
Sbjct: 1426 EMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1485

Query: 5118 NDTEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
               E K  E  ++++  +H     + LSE K+ V +V     +IV  ++  +  E     
Sbjct: 1486 PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE----- 1540

Query: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5235
                 L   +T +   +  L A   ++++ LE  +        ++   TE +     +L 
Sbjct: 1541 -----LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1595

Query: 5236 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5295
              SA +   + L + + +      E+E+Q+  L     ++++ + +      G++  L++
Sbjct: 1596 KRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVE 1650

Query: 5296 E-ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEID 5354
            + ++ +    + +  + +    L+ +  K  E  +  ++ +  W+ +    L     +  
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710

Query: 5355 AQLEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALD 5406
             Q E+ L+ L  E  + R  ++   ++              L     SEL+ + A ++  
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHR 1770

Query: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KV 5464
            +K   +    +KE+EQ  +              D+  +L  L+A+    V  K +   K 
Sbjct: 1771 IKT-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKD 1815

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQ 5524
            + E+ +G   +L++    +Q+ +    +  +   K+  +L +     ++   ++  K   
Sbjct: 1816 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKAL 1873

Query: 5525 AASHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSE 5582
              SH   +Y    + +LK ++   K LA       S  + R++         + KEID E
Sbjct: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRE 1918

Query: 5583 LEAMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIR 5623
            L+   E+L  +           +    E    Q+++  RE E            Q+  +R
Sbjct: 1919 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1978

Query: 5624 LQNLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5675
             + +    +DM          +  E+  +  AL + +  L +P++     ++     + L
Sbjct: 1979 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2038

Query: 5676 LSEMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5732
             +  +SL+    ++  +   ++A       V  + L  A  +L  +  ++      +   
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2098

Query: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEEL 5784
               +V ++ ++  ++K   Q +  A + +    +  +         ++ELQ  I + + +
Sbjct: 2099 FDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTV 2158

Query: 5785 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
             + +    E+I   +SK     ++ K  ++ L   EV
Sbjct: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2195



 Score =  108 bits (269), Expect = 3e-22
 Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)

Query: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
            ++  ED++  + L+++  N D    A +EV +W+    D L+  G + + +      F  
Sbjct: 322  LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 381

Query: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
            HE                  LG +L    ++     + +Q     L+     L  A  ++
Sbjct: 382  HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 441

Query: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
            Q++L   ++D +   + L+ L  W+ + EE       +   +   +   +E+LK Q+ + 
Sbjct: 442  QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 493

Query: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
              +  DL+    R+N L + + + D+           ++++ L   W+ I   T +R+  
Sbjct: 494  KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553

Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
            LQ  LL+ Q   E+   +  +L + E  +    +  ++            Q EM S  Q 
Sbjct: 554  LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 602

Query: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
            L  +  D    LE+ +      ++LK  LLS      +   Q+    +D+  R W     
Sbjct: 603  LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 653

Query: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
            + +KL K   ++S      + +    L Q   +     V  +E++ ++     +      
Sbjct: 654  LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 709

Query: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
            K+  ++ DS     L  ++ E+   W + S  + +  +   F      + E   +D  EK
Sbjct: 710  KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 762

Query: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
            +   +++ ++                ++L++A  S        +L++  ++  ++AD I 
Sbjct: 763  VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 802

Query: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
              +E+   L  +W E C  LS       ERLN W  +          L Q+E   +   +
Sbjct: 803  QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 851

Query: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
             L I+          + ++ I ++   +L  +  ++ +   +S A +        ++   
Sbjct: 852  WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
                + ++ +   + AR K+L+     +  +   + MS++RTW+   E++L+ P +    
Sbjct: 912  VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 970

Query: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
            + E ++++L E Q LQ  +++  +G    L      + +    A        Q     ++
Sbjct: 971  DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1026

Query: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
             RW+ + +  +E   K+EE     +K  +     + W+        E   A   S     
Sbjct: 1027 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1082

Query: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
             + K++LK+       +      L  +N+  +++  E   + A  L+  + E N +WD++
Sbjct: 1083 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1141

Query: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
             ++V +    LK  + +    +     +  W+T+ + +    + E+ +  ++Q  ++++K
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201

Query: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
              ++E      K++ +      +I ++ P+    +++EL+ L    Q +  R        
Sbjct: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1253

Query: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
                       L+ +   LE+  A     WH+     LLS    +N  L+  +     ++
Sbjct: 1254 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1291

Query: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
              + P   + I    D   +L R  E   +  R L     +G    +         +   
Sbjct: 1292 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1351

Query: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
              L  +  +  K L+ S    Q+TE  +     +   +D     Y+    + +      +
Sbjct: 1352 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1411

Query: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
            +++  L   E SL      +  +     V+ + ++  AQ   +++ MK  L QK   F  
Sbjct: 1412 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1469

Query: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
             L      L + +  L  L+    S + + ++ Q+     L K++   K+ +  +     
Sbjct: 1470 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527

Query: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
            +  Q    E+ ++L +R++ +   ++ + + + E +  L+  L   +   +  + L   L
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587

Query: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
               D    +++ +  + SNLD+E+
Sbjct: 1588 AATDMELTKRSAVEGMPSNLDSEV 1611



 Score = 65.9 bits (159), Expect = 2e-09
 Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)

Query: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
            PS+  E  +DK F    +   V L    +ALE  +  L  A D  + Q  I     +++ 
Sbjct: 318  PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 377

Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
            +  T       ++GYM  L      + ++ +L  KL       ++EE  +   +NL ++ 
Sbjct: 378  QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 429

Query: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
                    RWE L+  ++ K+  + + L   Q  N  L  +  WL  TEE   +++   L
Sbjct: 430  --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 479

Query: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
              D++ ++ Q+++ K LQ+ ++  +  + S+ ++       +    +  L+++L  +  R
Sbjct: 480  GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 539

Query: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
            W  +C   E+   LLQD L++ Q   E        L   +   N+I         E+L  
Sbjct: 540  WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599

Query: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
              K L  +K +L + +  +  L  +   LL
Sbjct: 600  LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 628



 Score = 49.3 bits (116), Expect = 2e-04
 Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)

Query: 134  QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
            Q++ L   LP  Q +    +     V    P  P ++    K++   K+  L+W++ +  
Sbjct: 2252 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2308

Query: 194  ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
               KQ  IE  +KD G+  +        ++ +   L  +       N+ N E  F + ET
Sbjct: 2309 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2368

Query: 249  ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 299
            E+          V   +PD + I++      K  P        + + S++ +  + +L  
Sbjct: 2369 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2419

Query: 300  ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 321
                     PG  +   S         Q    ++  I K                     
Sbjct: 2420 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2479

Query: 322  -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 376
             E+  W+   ++ +   +++  +L+D  +     K      E +R Q+E LI        
Sbjct: 2480 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2539

Query: 377  KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 424
            K S  +A          ++  WD V   L +   QL++ L         WL   E A   
Sbjct: 2540 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2595

Query: 425  ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 481
                R ++   +    T + IQ+K+ + K L ++     R +       +   + +  D 
Sbjct: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2651

Query: 482  LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 533
              D   + H ++     S   +H    E    LE  +RLL    L   K  +W+ +    
Sbjct: 2652 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711

Query: 534  ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 579
             +V Q        +E+SK                E +   Y  L + ++  +++    ++
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771

Query: 580  AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 639
            A  + + ++    +W  L  +  ++RS LE     W R   ++  L  WL+  +  L++ 
Sbjct: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831

Query: 640  ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 695
                 DF       +Q+   ++ A    ++T + ++   L+   + L  +      +L+ 
Sbjct: 2832 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2886

Query: 696  EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 748
            E ++     +A  + R+ ++  + V T    L+  + +  +K+ E LE         +Q+
Sbjct: 2887 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2938

Query: 749  LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 808
            L++    + +   Q ++I        K S Q  G  +  ++    E++  ++   +PL  
Sbjct: 2939 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2988

Query: 809  ESQQLLIPLEELEKQMTSFYDSLGKIN 835
              ++ +  + +L +Q+T+    L   N
Sbjct: 2989 --KENVSHVNDLARQLTTLGIQLSPYN 3013



 Score = 35.4 bits (80), Expect = 2.5
 Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)

Query: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
            ++   WE L    ++ QR + E LER Q+ Q++   +  K+   E+        G     
Sbjct: 2910 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2969

Query: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
             + +H    +AL  EI  L++ ++ + + LA +L +   +  P       STL  L  R 
Sbjct: 2970 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3024

Query: 6055 STIRMKASGKRQLLEEKLND 6074
              +++    + + L E   D
Sbjct: 3025 KLLQVAVEDRVRQLHEAHRD 3044


>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform 2
            [Homo sapiens]
          Length = 429

 Score =  309 bits (791), Expect = 9e-83
 Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)

Query: 8357 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 8413
            R+  P  P   T YK   G + L        +  + L    ++E+  L G         Q
Sbjct: 5    RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58

Query: 8414 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 8473
             +G  DRWE++QAQ L  +L++KQNLQ   Q NSD+++I  WL  TE ELE L+  +  +
Sbjct: 59   QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115

Query: 8474 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8533
            DIQ IEL++K+L+E+ KA D  KA+++S+N+ S EF Q +S ES +LQ RL Q++  W+ 
Sbjct: 116  DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175

Query: 8534 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 8579
                ++ WRG L+ +LMQCQG              FH++S  LLL L +   R+ +    
Sbjct: 176  AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235

Query: 8580 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 8639
            D   D   L +  ++LMQ++ EL+E Q +V  LQ++S  LL+   G DC+EA+EKVHVI 
Sbjct: 236  DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295

Query: 8640 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 8699
             +LK L ++VS+ +  L+       +Q   S   S DE+D SG   P +           
Sbjct: 296  KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337

Query: 8700 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 8759
                  S P P       R+T+G  ++    PG  R  R FL RV+RAALPLQLLLLLL+
Sbjct: 338  ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391

Query: 8760 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8796
             LACL+P SEEDYSC  +NNFARSF+PMLRYTNGPPP
Sbjct: 392  LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428



 Score = 41.2 bits (95), Expect = 0.046
 Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)

Query: 5909 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5968
            TD  K  P         E G     T +       WE ++   +++     +  +  Q+ 
Sbjct: 31   TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87

Query: 5969 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 6023
               + +I+T ++  E     LK+++ P   +  E ++   Q ++      +  +  +  S
Sbjct: 88   NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147

Query: 6024 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6083
              E L +ES E+   +    Q +L   A +   +     G RQ L +    +   +    
Sbjct: 148  SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206

Query: 6084 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
              + +   +  L  WL S K     A +    + P+  ++   +LM  +  LVE + +V 
Sbjct: 207  FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266

Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 6195
             L E+S    +LL++G      EAE+   K+  ++  L +L+  +    + +QGT     
Sbjct: 267  MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320

Query: 6196 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6230
                 ++ +S     AT  P  +      RTT  ++   S
Sbjct: 321  PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360



 Score = 36.2 bits (82), Expect = 1.5
 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)

Query: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7918
            DRW+ +         K+K+ L   QQL+ ++S++ TWL   E+EL     AKP      +
Sbjct: 64   DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116

Query: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASV 7946
             +EI+ ++   QE+ +  + +   V SV
Sbjct: 117  IQEIELRVKRLQEILKAFDTYKALVVSV 144


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score =  296 bits (759), Expect = 5e-79
 Identities = 596/3138 (18%), Positives = 1240/3138 (39%), Gaps = 523/3138 (16%)

Query: 13   DIANVMQRLQDEQEIVQKRTFTKWINSHLAKR-KPPMVVDDLFEDMKDGVKLLALLEVLS 71
            + +++++   DE   VQK+TFTKWIN+  +K  KPP  ++D+F D+KDG KLL LLE L+
Sbjct: 17   EFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPP--INDMFTDLKDGRKLLDLLEGLT 74

Query: 72   GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIIL 131
            G  LP E+G    R+HA+ N+   L+ L    ++LVNI  TDI DG   + LGL+W+IIL
Sbjct: 75   GTSLPKERGST--RVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIIL 132

Query: 132  YFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYT 191
            ++Q++++  ++                             ++   Q N++K LL WV+ T
Sbjct: 133  HWQVKDVMKDV-----------------------------MSDLQQTNSEKILLSWVRQT 163

Query: 192  AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 251
                + + V +F  SW  G+AF++V+H  +P+L   + V   S  E LE AF+ A+T LG
Sbjct: 164  TRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLG 223

Query: 252  IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPD-------------------------IH 286
            I +LLDPEDV V  PD+KSI+ Y+    +  P                          I+
Sbjct: 224  IEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAIN 283

Query: 287  NASTDGQEDDEI-LPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQ 345
              ST  +E+ E      PS    V       ++  +E+  W+   E        +  +++
Sbjct: 284  IQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVE 343

Query: 346  ---DKYQSFKHFRVQYEMKRKQIEHLIQ---PLHRDGKLSLD----------------QA 383
               D++ + + F ++    +  +  ++Q    L   G LS +                +A
Sbjct: 344  EVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403

Query: 384  LVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQ 443
            L  +S DR  SRL D  ++L K     L  + AWL   E  +++  T     ++   ++Q
Sbjct: 404  LRVESMDR-QSRLHDVLMELQKK---QLQQLSAWLTLTEERIQKMETCPL--DDDVKSLQ 457

Query: 444  RKLEQHKDLLQNTDAHKRAFHE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTS 496
            + LE+HK L  + +A +   +        +      +   +  DQL+ + ER+  V   +
Sbjct: 458  KLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWT 517

Query: 497  ELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQY 556
            E    +++ + +   L   L+  +  LK+W+ +  + E++ +        ++ S F +Q 
Sbjct: 518  EERWNRLQEINI---LWQELLEEQCLLKAWLTE--KEEALNK--------VQTSNFKDQK 564

Query: 557  EVTYQ-----ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEV 611
            E++       ILK+  EM  +    + E       + +   Q  + S   + + S  EE+
Sbjct: 565  ELSVSVRRLAILKEDMEMKRQTLDQLSE-------IGQDVGQLLDNSKASKKINSDSEEL 617

Query: 612  ISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETC 671
               WD     +      +  A   L  S+  +KD                      +   
Sbjct: 618  TQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLET------------------VRVR 659

Query: 672  DEMVSRDLKQQL-LLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT-LSAFATEAHK 729
            ++ +++  KQ+L      + R++ ++++      + D +  E  + ++   +A  T   K
Sbjct: 660  EQAITKKSKQELPPPPPPKKRQIHVDIE---AKKKFDAISAELLNWILKWKTAIQTTEIK 716

Query: 730  KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
            +  +  + S M  KL   + E   +R+P  D     + +T  ++     ++ GKE   T 
Sbjct: 717  EYMKMQDTSEMKKKLKALEKEQ-RERIPRADE----LNQTGQILV----EQMGKEGLPT- 766

Query: 790  SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
             ++K  L KV   +  +    + L   + +L++ + +++  L ++ ++I   E   + ++
Sbjct: 767  EEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINAYFKQLDELEKVIKTKEEWVKHTS 825

Query: 850  LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQ 909
            + +   Q L + +++C++ LT                              +  +H   +
Sbjct: 826  ISESSRQSLPSLKDSCQRELT-----------------------------NLLGLHPKIE 856

Query: 910  SMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQ 969
                              + + F+      + V    QE +E++       ++H E  ++
Sbjct: 857  MARASCSALMSQPSAPDFVQRGFDSFLGRYQAV----QEAVEDR-------QQHLE--NE 903

Query: 970  LDQRVLNAFLKACDELTDILPEQEQ--QGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVE 1027
            L  +  +A+L+    L D+L + E   Q     +  L K  K LQ +             
Sbjct: 904  LKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTL---------- 953

Query: 1028 KNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD-KGPHH----LCEKRLQLIE 1082
             +  L + +    +L  ETK + +     + K ++  F D +G  +    L  K L L+E
Sbjct: 954  -DEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE 1012

Query: 1083 ELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK--WKDYTSRFSEFSSWI 1140
            E+ + L      R       V  K +    D   ++     D    +    + S F + I
Sbjct: 1013 EIALTL------RAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEI 1066

Query: 1141 STNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEA 1200
             T E+ LK +K   I+T            +R+G     +T  W+++RL          + 
Sbjct: 1067 ETIESSLKNMK--EIET-----------NLRSGPVAGIKT--WVQTRL---------GDY 1102

Query: 1201 QKQGDELAKLSSSFKALVTLLSEVEKMLSNF-GDCVQYKEIVKNSLEELISGSKEVQEQA 1259
            Q Q   L KLS       + LSE ++  +N   D  + +E +  + EE +    E +   
Sbjct: 1103 QTQ---LEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPE 1159

Query: 1260 EKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLES 1319
            E     E +  A++ +L   QK  R+   K +++   A+       +P  G E   +L  
Sbjct: 1160 ELESAVEEMKRAKEDVL---QKEVRVKILKDNIKLLAAK-------VPSGGQELTSELNV 1209

Query: 1320 TLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSEL 1379
             L+  +    R   +       W  +       +  L      H   L  + L +L   +
Sbjct: 1210 VLENYQLLCNRIRGKCHTLEEVWSCW-------IELL------HYLDLETTWLNTLEERM 1256

Query: 1380 EQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIK 1439
            + T+   ++T+++    E+L             + +L+  A + + Q+++L  TL +   
Sbjct: 1257 KSTEVLPEKTDAVNEALESL-------------ESVLRHPADN-RTQIRELGQTLIDGGI 1302

Query: 1440 TMEMVKTKWDHFGSNFETLSVWITEK----EKELNALETSSSAMDMQISQIKVTIQEIES 1495
              +++  K + F S +E LS     K    EK+L  L  +    D  +  ++ ++ E++ 
Sbjct: 1303 LDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRET----DQMLQVLQESLGELDK 1358

Query: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL-----EGTILGH 1550
            +L++ +    +A     F    E+ +I+A+++      EELR + +       E      
Sbjct: 1359 QLTTYLTDRIDA-----FQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413

Query: 1551 LSQQQKFEENLRKIQ------QSVSEFE----------DKLAVPIKICSSATETYKVLQE 1594
             SQ    +  LR++       Q  + FE          D +   + +         V+Q 
Sbjct: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQT 1473

Query: 1595 HMDLC----QALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAK 1644
            H+D C    + L  +   +     + R +V      N     ++  +L+  Y D+  +  
Sbjct: 1474 HLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVT 1533

Query: 1645 ERQTALENLLAHWQRLEKELSSFLTWLERGEA----KASSP----EMDISADRVK-VEGE 1695
            E +  LE      ++++KE +S   WL   E     K++S     ++D      K V  +
Sbjct: 1534 EGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKD 1593

Query: 1696 LQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINK 1755
            L+  +A  N +   ++    L++  E +           ++  L  L+  W  +      
Sbjct: 1594 LEKRKADLNTITESSAALQNLIEGSEPI-----------LEERLCVLNAGWSRVRTWTED 1642

Query: 1756 RINFLQSVVAEHQQFDELLLSFSVWI---KLFLSELQ---TTSEISIMDHQVALTRHKDH 1809
              N L +   + + FD  +   S W+   +  L E++   T+ +  I+   V        
Sbjct: 1643 WCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV-------- 1694

Query: 1810 AAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH 1869
             +E++    ++++++     L +   +    L++ K  +  + FE+ SQ ++  +L ++ 
Sbjct: 1695 -SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIA- 1752

Query: 1870 LAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNAKALESAA 1923
                 Q       +  +  +T    + + K E+D+      +EK L  + ++ K  E +A
Sbjct: 1753 -----QEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESA 1807

Query: 1924 VSLDGILSKAQYHL-KIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALA----- 1977
              ++ +L + +  L +     ++   R     L     +I+  +  +Q +   LA     
Sbjct: 1808 -QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIK-AIPIQQRKMGQLASGIRS 1865

Query: 1978 -VLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC 2036
             +L   +  +  ++L  ++D+E   +   L     +    +      ++D+L+    ++ 
Sbjct: 1866 SLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA 1925

Query: 2037 WLKDKAKQ-IAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             + +K    I +     A ++   + +L   WD   R+  + +G     ++  R++    
Sbjct: 1926 VIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDL 1985

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
            + +++ +  A  ++V         DL+ A    +  +  ++  Q         G  +   
Sbjct: 1986 NDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGI--- 2042

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
            ++K+  +D S +K  +     +W  +  ++++   RL+             DEI  W   
Sbjct: 2043 VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLT- 2101

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQ 2275
                            +AE  +++  +          EL   + +L++LT+ +E      
Sbjct: 2102 ----------------KAEHAMQKRST---------TELGENLQELRDLTQEMEV----- 2131

Query: 2276 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL--MNCAQN 2333
                       HA+++  + +  L+  + +S  + +          K+ ESL  +N   N
Sbjct: 2132 -----------HAEKLKWLNRTELEMLSDKSLSLPE--------RDKISESLRTVNMTWN 2172

Query: 2334 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393
            + C   ++V    KE   + S++S T+   +   +K                +    + S
Sbjct: 2173 KIC---REVPTTLKECIQEPSSVSQTRIAAHPNVQK----------------VVLVSSAS 2213

Query: 2394 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
             +  ++  + + S+     +++ E  +W +      K +    GD + +   +  ++   
Sbjct: 2214 DIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITK 2273

Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHL-SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2512
              +     +LD V    Q L     S  + ++I E++ +   ++          +Q L+D
Sbjct: 2274 ADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLED 2333

Query: 2513 CASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK---NEVHKVEMFLGELLA 2569
               +   ++D   +    + + E R     L ++++    K+   N++   E+  G+ + 
Sbjct: 2334 MIIDSLQWDDHREETEELMRKYEARLYI--LQQARRDPLTKQISDNQILLQELGPGDGIV 2391

Query: 2570 ARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLL-TSHQNLLRMTKEKLRSCQVALQEHEA 2628
               + D + Q+  LL E G    +  +  ++ L TS  NL +   ++  + +   +  +A
Sbjct: 2392 M--AFDNVLQK--LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQA 2447

Query: 2629 LEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKG--------EGEVK 2680
                L++   W++        AE+T+        R + +QD +L +         + E+ 
Sbjct: 2448 SRRDLENFLKWIQE-------AETTVNVLVDASHRENALQDSILARELKQQMQDIQAEID 2500

Query: 2681 LNMAIGKGEQALRS------SNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQ 2734
             +  I K     R        N E   ++Q +L+ + + W D+ + S   ++ LE+   +
Sbjct: 2501 AHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEK 2560

Query: 2735 WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
            WN  +    +L +W+   D++++  +     +    +  DH +++  E ++   ++   +
Sbjct: 2561 WNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAV 2620

Query: 2795 AKSRELYEKTEDESFKDTAQE-ELKTQFNDIMTVAK--EKMRKVEEIVKDHLMYLDAVHE 2851
             ++R        E+ ++  +  + KT+        K  + MRK    VK+    L+AV  
Sbjct: 2621 DQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAV-- 2678

Query: 2852 FTDWLHSAKEELHRWSDMSG---DSSATQKKLSKIKE--------LIDSREIGASRLSRV 2900
             ++W     + L +  D+ G   D  A  K+   ++         LIDS +    ++   
Sbjct: 2679 TSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAF 2738

Query: 2901 -ESLAP---EVKQ----NTTASGCEL-----MHTEMQALRADWKQWEDSVFQTQSCLENL 2947
             E +AP   +VK     ++  S  +L     M  ++  L   WK  + SV      L+  
Sbjct: 2739 REEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEA 2798

Query: 2948 VSQMALSEQEFSGQVAQL 2965
                  S Q F     QL
Sbjct: 2799 HRDFGPSSQHFLSTSVQL 2816



 Score =  160 bits (404), Expect = 7e-38
 Identities = 497/2812 (17%), Positives = 1064/2812 (37%), Gaps = 360/2812 (12%)

Query: 2754 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTR--ALHRLIAKSRELYEKTEDESF-- 2809
            +K+  P      L +K  ++ +L S+           A+  +    R+  ++ E+E+   
Sbjct: 225  EKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI 284

Query: 2810 KDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
            + TA EE      +  +   E    V E+  D   Y  A+ E   WL SA++      D+
Sbjct: 285  QSTAPEE------EHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDI 338

Query: 2870 SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE--LMHTEMQALR 2927
            S D    + + +  +  +       S +  V     ++    T S  E   +  +M  L 
Sbjct: 339  SDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLN 398

Query: 2928 ADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE 2987
            A W+         QS L +++ ++              ++ L+Q SA L    +++  +E
Sbjct: 399  ARWEALRVESMDRQSRLHDVLMELQ-------------KKQLQQLSAWLTLTEERIQKME 445

Query: 2988 GKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
                D+++            +LQK     + L+S          DL     KV+ L    
Sbjct: 446  TCPLDDDV-----------KSLQKLLEEHKSLQS----------DLEAEQVKVNSLT--- 481

Query: 3048 NCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKI 3107
            + + +      ++   IL+ + +K     ++W    + T  +       + E++   Q++
Sbjct: 482  HMVVIVDENSGESATAILEDQLQKL---GERWTAVCRWTEERW----NRLQEINILWQEL 534

Query: 3108 QE-------FLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3160
             E       +L+E E   +K+     K +       KE +  ++ ++   KED +     
Sbjct: 535  LEEQCLLKAWLTEKEEALNKVQTSNFKDQ-------KELSVSVR-RLAILKEDMEMKRQT 586

Query: 3161 LHQKE-------SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ 3213
            L Q           L+N K   K    S E  Q W S  +++  +SSN++    AK    
Sbjct: 587  LDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRL-EDSSNQVTQAVAKLGMS 645

Query: 3214 QKLQ-SVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKV 3272
            Q  Q  +LE +   E  +   K+  Q+L       K   H   +   ++ A+S      +
Sbjct: 646  QIPQKDLLETVRVREQAIT--KKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI 703

Query: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3332
             +         + ++   E++++M               D S +     KL+AL   ++E
Sbjct: 704  LKW--------KTAIQTTEIKEYM------------KMQDTSEMKK---KLKALEKEQRE 740

Query: 3333 KEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDMWASL------LSAGIRCKSQL 3384
            +  +   +   G+ +++    EG+PT  I+  L+ V   W ++      L   I+ +  +
Sbjct: 741  RIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDI 800

Query: 3385 EGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE------LRDKTTMLGKAKLLNEE 3438
                 +    +  ++    W+     +++ES RQ          R+ T +LG    +   
Sbjct: 801  NAYFKQLDELEKVIKTKEEWV--KHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMA 858

Query: 3439 VLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLH--QE 3496
              S S+L+                Q        RY+A+QE  ++     E  ++      
Sbjct: 859  RASCSALMSQPSAPD-------FVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHA 911

Query: 3497 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTR 3556
            Y   LK  +  L   + K      +  D    E  L++ + L       +  L+ +    
Sbjct: 912  YLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEET 971

Query: 3557 EDVIPSGIPQAE---DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEW 3613
            + +  +  P  E    +  + ++  W   +  +S+       +   LR  E     +++W
Sbjct: 972  KALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKW 1031

Query: 3614 LKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVE-----EVGARAQEILD- 3667
            +   ++ +  +   Q + A  + QL Q   +  E+      ++     E   R+  +   
Sbjct: 1032 MDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGI 1091

Query: 3668 ESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKN 3727
            ++ V +R+G   TQL    + L  ++  Q   L E  +     +  L+   +W     + 
Sbjct: 1092 KTWVQTRLGDYQTQL----EKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEE 1147

Query: 3728 FKNVATKI---DKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAE 3784
            +     +    +++++ +   K    +VL K++      +K  ++  +     +  G  +
Sbjct: 1148 YLERDFEYKSPEELESAVEEMKRAKEDVLQKEVR-----VKILKDNIKLLAAKVPSG-GQ 1201

Query: 3785 RLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
             L  E++  +E  + L + +R +  TLE+      E        T W+   +E +   E 
Sbjct: 1202 ELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE- 1260

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKS-VREKGEALLE-LVQDVTLKDKIDQLQSD 3902
                L EK   +++     ++VL H    ++ +RE G+ L++  + D  + +K++   S 
Sbjct: 1261 ---VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSR 1317

Query: 3903 YQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVA--PDLLET----SSL 3956
            Y+DL  + +    SLE +++   + +  LQ +++ L ++  +L     D ++        
Sbjct: 1318 YEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEA 1377

Query: 3957 ETITQQLAHHKAMMEEI-AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            + I  +++ H+  +EE+      +            G   D LQ KL++           
Sbjct: 1378 QKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLRE----------- 1426

Query: 4016 SYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLE----PSPQPPLSRAE 4071
                  ST  +++       QK  + +  +  C+  L  V+ +L         P + +  
Sbjct: 1427 -----VSTKFQLF-------QKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTH 1474

Query: 4072 AIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQ--NLT 4129
              K +K ++ L E              L   +V  T + I Q +QT   K +  Q  +L 
Sbjct: 1475 LDKCMKLYKTLSE------------VKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLK 1522

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL-------ELNIAQNMVSQ-------- 4174
              + ++    +E    L+ A Q  + MK+  + L       E  + Q   S+        
Sbjct: 1523 VLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDT 1582

Query: 4175 ----VKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE---HKEINHLNDQWLDLCRQSNN 4227
                 K+ +K L+ ++A +NTI E    L    E  E    + +  LN  W  +   + +
Sbjct: 1583 EISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTED 1642

Query: 4228 LCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE 4287
             C        +   +   +  +  +L +     D +   + + T+   E +K+L   L +
Sbjct: 1643 WCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEI---EKKPTSKQEEIVKRLVSELDD 1699

Query: 4288 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK-RKIQVSVTNLEEL 4346
                +E+++DQ   ++       +ELV+ + + L + + ++   IK  K+ ++   L + 
Sbjct: 1700 ANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQC 1759

Query: 4347 NVVQSRFQELMEWAE-EQQPNIAEAL-----KQSPPPDMAQNLLMDHLAICSELEAKQML 4400
             V    F+  + +++ E+  N  E +     K     D  + +  +   I   L+  + +
Sbjct: 1760 LVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEM 1819

Query: 4401 LKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEK----- 4455
            L   ++D          N+++ I+  L    +  N +  +  Q+RK    A   +     
Sbjct: 1820 LHQPMED----------NKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLP 1869

Query: 4456 TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWA 4515
            T +L+ + +    +   E  +   E    + +D S Q  + K+ +  L     ++  +  
Sbjct: 1870 TDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHE 1929

Query: 4516 QGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
            +  +++ E +  E  ++   L +L + +D + +  S R    ++ +   + F  D +   
Sbjct: 1930 KQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLT 1989

Query: 4576 HWLKQADIVTF----PEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4631
             W+ +A+ +      P  +L  E + +H Q  +   I    P +      L RTG  I+ 
Sbjct: 1990 QWITEAEELLVDTCAPGGSLDLEKARIHQQELEV-GISSHQPSF----AALNRTGDGIVQ 2044

Query: 4632 SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELE 4691
             L++ D S+L EKL  L ++++ IVA  KD+  +++       +Y   ++     L++ E
Sbjct: 2045 KLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAE 2104

Query: 4692 AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK 4751
                + S   T+L               L E+  L + ++   +K +    T      DK
Sbjct: 2105 HAMQKRS--TTELGEN------------LQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150

Query: 4752 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA 4811
             L L            +R  + E   +      K+C+++   LK   +E S V++  + A
Sbjct: 2151 SLSL-----------PERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAA 2199

Query: 4812 EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSA 4871
               ++    L  S  D       + +     +    P   +K   ++  W   +  +  +
Sbjct: 2200 HPNVQKV-VLVSSASD-------IPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251

Query: 4872 IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP----VYLDLNLQDIQEEIRKI 4927
               TV + E           E+++++  ++  KA+L        Y+    Q+++ +    
Sbjct: 2252 NIVTVGDVE-----------EINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSS 2300

Query: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDG---DIQEALRTR 4984
             +     +   R+ N     + +      EL    LE  + +  + D    + +E +R  
Sbjct: 2301 DMRTAITEKLERVKN-----QWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355

Query: 4985 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEEN-LKSHMEFFSTED 5043
            +A L  I  Q +R           + D Q LLQ  G G  +  A +N L+  +E + ++D
Sbjct: 2356 EARL-YILQQARR-----DPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDD 2409

Query: 5044 QFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5103
                N++E    + T    +K +  +   Q     E R+ + SR          R    +
Sbjct: 2410 T--RNVKETTEYLKTSWINLKQSIAD--RQNALEAEWRTVQASR----------RDLENF 2455

Query: 5104 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALE 5163
              + +  E  + ++ D   +  E +L  +  + E ++++ + +A +   N   + I    
Sbjct: 2456 LKWIQEAETTVNVLVDASHR--ENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNR 2513

Query: 5164 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5223
            +K   ++  GN      L   +  + QRW  L+A +      LE + ++W      +++ 
Sbjct: 2514 QK--MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEEL 2571

Query: 5224 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGA 5283
             + ++   ++L            L    ++      EL++++ ++     Q    L D  
Sbjct: 2572 IKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQP 2631

Query: 5284 APTPGEEPPLMQEITAM--QDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5341
               P E    +Q  T +  ++R   + + ++     VK++ +    V +          E
Sbjct: 2632 IEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALE 2691

Query: 5342 TKEYLGNPTIEIDAQLEELQ-----------ILLTEATNHRQNIEKMAEEQKEKYLGLYT 5390
                L     ++DA ++E +           +L+    +H + I    EE       + T
Sbjct: 2692 KLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKT 2751

Query: 5391 ILPSELSLQLAEVAL--DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKD 5440
            +  ++LS QL+ + L   LK+  Q+ D     +  + +  +  +Q+Q+  +D
Sbjct: 2752 V--NDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRD 2801



 Score =  150 bits (378), Expect = 7e-35
 Identities = 509/2783 (18%), Positives = 1066/2783 (38%), Gaps = 405/2783 (14%)

Query: 1492 EIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILG-- 1549
            ++  K S I+ L    +   Q VT      ++   T  R+Y +E  E A  ++ T     
Sbjct: 236  QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVE---TLPRKYKKECEEEAINIQSTAPEEE 292

Query: 1550 HLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKV-------LQEHMDLCQAL 1602
            H S + +    + ++   +  ++  L   +    SA +T++        ++E  D     
Sbjct: 293  HESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATH 352

Query: 1603 ESLSSAITAFSASARKVVNRDSCV---------------QEAAALQQQYEDILRRAKERQ 1647
            E+    +TA  +S   V+   + +               ++   L  ++E +   + +RQ
Sbjct: 353  EAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQ 412

Query: 1648 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEV 1706
            + L ++L   Q+  K+L     WL   E +    E     D VK ++  L+  ++LQ+++
Sbjct: 413  SRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDL 470

Query: 1707 VSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1766
             ++    + L  +   +   + +    +++  L++L ERW  + +   +R N LQ +   
Sbjct: 471  EAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530

Query: 1767 HQQFDELLLSFSVWI--------KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKG 1818
             Q+  E       W+        K+  S  +   E+S+   ++A+ +      ++E K+ 
Sbjct: 531  WQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKE-----DMEMKRQ 585

Query: 1819 ELQSLQGHLAKLGSL-GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH-LAEFLQS 1876
             L  L      +G L   ++    +   +E+  Q ++   Q +E     ++  +A+   S
Sbjct: 586  TLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMS 645

Query: 1877 HASLSGILRQLRQTVEATNSMNKNE----SDLIEKDLNDALQNAKALESAAVSLDGILSK 1932
                  +L  +R   +A    +K E        ++ ++  ++  K  ++ +  L      
Sbjct: 646  QIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAEL------ 699

Query: 1933 AQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ--DQKEEL 1990
              + LK  ++ Q T           E++    +  T + +    A+ K+  +   + +EL
Sbjct: 700  LNWILKWKTAIQTT-----------EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADEL 748

Query: 1991 LKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2049
             ++ + + E+  KE L  E  +  L++    +  +   L   E ++   +D      Q D
Sbjct: 749  NQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLD 808

Query: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLID-LMREYQNLKSAVSKV-LENAS- 2106
                 E+++ I   E  W     +   ++     L D   RE  NL     K+ +  AS 
Sbjct: 809  -----ELEKVIKTKE-EWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASC 862

Query: 2107 SVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTS--KGKHLLSELKKIHSS 2162
            S ++++ +  D  Q        +++  +  +  +Q+ L+N      G   L  LK +   
Sbjct: 863  SALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKD- 921

Query: 2163 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2222
                V  D E+     L+V   L +    L+           T DEI       + ++AE
Sbjct: 922  ----VLNDSENKAQVSLNVLNDLAKVEKALQEK--------KTLDEILENQKPALHKLAE 969

Query: 2223 NISNLDN--HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD 2280
                L+   H   E+L K+   +V+ K  +L+ L SK               DL  +E  
Sbjct: 970  ETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSK---------------DLHLLE-- 1012

Query: 2281 LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA----QNETC 2336
                        E+A  TL+ F A ST +EK+++ +  +  K + +  + A    Q + C
Sbjct: 1013 ------------EIAL-TLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059

Query: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELES-LGRAMTGLIKKHEAVSQL 2395
             A   V +I+  ++S   N+   + NL S         +++ LG   T L    E +S+ 
Sbjct: 1060 SAF--VNEIET-IESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQL----EKLSKE 1112

Query: 2396 CSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
             +  ++ L ES EK  +  + + E QEW   A+    E        + LE+ + +++   
Sbjct: 1113 IATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAK 1172

Query: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK------ 2507
            + V   + ++  +    + L A    ++ S  QE  ++ N   + +   C + +      
Sbjct: 1173 EDVLQKEVRVKILKDNIKLLAA----KVPSGGQELTSELNVVLENYQLLCNRIRGKCHTL 1228

Query: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHK-VEMFLGE 2566
            + +  C  EL  + D       W++ +EER       +S + +PEK + V++ +E     
Sbjct: 1229 EEVWSCWIELLHYLDLE---TTWLNTLEERM------KSTEVLPEKTDAVNEALESLESV 1279

Query: 2567 LLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626
            L    ++  ++ + GQ L + G              + +++L  + + K  S +  LQ  
Sbjct: 1280 LRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339

Query: 2627 EALEEALQSMWFWVKAIQDRLACAESTLGSKDT-LEKRLSQIQDILLMKGEGEVKLNMAI 2685
               ++ LQ +              + +LG  D  L   L+   D   +  E + K+   I
Sbjct: 1340 RETDQMLQVL--------------QESLGELDKQLTTYLTDRIDAFQVPQEAQ-KIQAEI 1384

Query: 2686 GKGEQALRS--SNKEGQRVIQTQLETLKE-VWADIMSSSVHAQSTLESVISQWNDYVERK 2742
               E  L     N   Q +   +  T +     D++   +   ST   +  +  ++ +R 
Sbjct: 1385 SAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRM 1444

Query: 2743 NQLEQWMESV-------DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
               ++ ++ V       D K   P   Q  L +   L   L  +  E E   +    ++ 
Sbjct: 1445 LDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQ 1504

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDI---MTVAKEKMRKVEEIVKDHLMYLDAVHEF 2852
            K     ++T++    D     LK  +ND+   +T  K+ + +  ++ +   M  +A    
Sbjct: 1505 K-----QQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK--MKKEAA-SL 1556

Query: 2853 TDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTT 2912
            ++WL + + EL + S   G       ++S  K ++   E   + L+ +   +  + QN  
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAAL-QNLI 1615

Query: 2913 ASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQF 2972
                 ++   +  L A W +         + L N  +Q+ +    F G VA +   L Q 
Sbjct: 1616 EGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI----FDGNVAHISTWLYQA 1671

Query: 2973 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQ----LNELCR 3028
             ALL    ++ T     +  EEIV+       ++  L  A  + E+++ Q    +N    
Sbjct: 1672 EALLDEIEKKPT-----SKQEEIVK------RLVSELDDANLQVENVRDQALILMNARGS 1720

Query: 3029 FSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI--T 3086
             SR+L      V   + E N    + S+  ++ + ++ Q          Q LV  +   T
Sbjct: 1721 SSREL------VEPKLAELNRNFEKVSQHIKSAKLLIAQE------PLYQCLVTTETFET 1768

Query: 3087 TAKCFDIPQNISEVSTSLQKIQEFLSESENGQH------KLNMMLSKGE-LLSTLLTKEK 3139
                 D+ +  +++   L+ +++ L  S+  +       ++  +L +GE +L   +   K
Sbjct: 1769 GVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNK 1828

Query: 3140 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES 3199
             + I+ ++             LH + + ++ + IQ +     A  I+  L  T+ +V  +
Sbjct: 1829 KEKIRLQLLL-----------LHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEIN 1877

Query: 3200 SNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAA----------- 3246
               L   D+       +   ++ E+    E  L  +K++  +L E  A            
Sbjct: 1878 KILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILE 1937

Query: 3247 -----SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
                 +   R  ++QL++++  ++ +  ++    DR + E  QF   + +L  W+T+A  
Sbjct: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997

Query: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3361
            +L   C P     +  +R  + E  + +   +      +   G+ ++Q  S      +++
Sbjct: 1998 LLVDTCAPGGSLDLEKARIHQQELEVGISSHQP-SFAALNRTGDGIVQKLSQADGSFLKE 2056

Query: 3362 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSME-----ANLNESE 3416
            +L  +   W ++++     + +L+G   +   Y+  + +   W+   E      +  E  
Sbjct: 2057 KLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELG 2116

Query: 3417 RQHAELRDKTTML----GKAKLLNE---EVLSYSSL-----------LETIEVKGAGMTE 3458
                ELRD T  +     K K LN    E+LS  SL           L T+ +    +  
Sbjct: 2117 ENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICR 2176

Query: 3459 HYVTQLELQDLQERYRAIQER---------------AKEAVTKSEKL--VRLHQEYQRDL 3501
               T L+ + +QE     Q R               A +   +S +   + +  +  + +
Sbjct: 2177 EVPTTLK-ECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTI 2235

Query: 3502 KAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVL----HTRE 3557
                 WL    + L    V  GD      T+  ++  +    +    L+ V     + + 
Sbjct: 2236 TELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN 2295

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTA 3617
                S +  A    LE ++  W   QH +   + Q  +++      +   ++ +E ++  
Sbjct: 2296 KASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355

Query: 3618 EEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3677
            E ++    + + +  TK+I  +Q+    +E+      V       Q++L+E   +     
Sbjct: 2356 EARLYILQQARRDPLTKQISDNQILL--QELGPGDGIVMAFDNVLQKLLEEYGSDDTRNV 2413

Query: 3678 QAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWY--GSTHKNFKNVAT 3733
            + T   L + +  L   + ++   LE E ++++ S   L ++  W     T  N    A+
Sbjct: 2414 KETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDAS 2473

Query: 3734 KIDKV--DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIH 3791
              +    D+++  +  + ++ +  +++  + + KS     ++ VK L   E   + +   
Sbjct: 2474 HRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRL 2533

Query: 3792 DHMEQ----LKELTSTVR-----------KEHMTLE--------KGLHLAKEFS------ 3822
            D M Q    LK  ++++R           +  M+LE        K   L K+        
Sbjct: 2534 DDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVP 2593

Query: 3823 ------DKCKALTQWIAEYQ----------------EILHVPEEPKMELYEKKAQLSKYK 3860
                  D CKAL + + E +                + +  PEEP+  L + K +L+  +
Sbjct: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNL-QSKTELTPEE 2652

Query: 3861 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAK 3920
              Q+   +       V+EK E+L  +  +   + ++D+     +DL    +  +  L+A 
Sbjct: 2653 RAQKIAKAMRKQSSEVKEKWESLNAVTSN--WQKQVDKALEKLRDL----QGAMDDLDAD 2706

Query: 3921 VKDHEDYNSELQEVEKWLLQ---------MSGR-LVAPDLLETSSLETITQQLA----HH 3966
            +K+ E   +  + V   L+          M+ R  +AP   +  ++  ++ QL+    H 
Sbjct: 2707 MKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHP 2766

Query: 3967 KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQR 4026
               M        +L++L M+   L     D    +LKQ   AH      S   + ++ Q 
Sbjct: 2767 SLKMSR------QLDDLNMRWKLLQVSVDD----RLKQLQEAHRDFGPSSQHFLSTSVQL 2816

Query: 4027 MYQ-SLEHELQKHVSRQDTLQQC 4048
             +Q S+ H    +     T   C
Sbjct: 2817 PWQRSISHNKVPYYINHQTQTTC 2839



 Score =  145 bits (365), Expect = 2e-33
 Identities = 489/2680 (18%), Positives = 1038/2680 (38%), Gaps = 361/2680 (13%)

Query: 5952 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMD 6008
            +E   T+ E       YQ +L+ + T + + E    E  +     E    Q A H+A M 
Sbjct: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357

Query: 6009 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 6068
            E+   Q  +  +  +   +L+++   +D  E+  +Q  +T+L  R   +R+++  +    
Sbjct: 358  ELTAHQSSVGSVLQA-GNQLITQGTLSDE-EEFEIQEQMTLLNARWEALRVESMDR---- 411

Query: 6069 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6128
            + +L+D L E +++Q  Q        L +WL  T+  +    + P +         D ++
Sbjct: 412  QSRLHDVLMELQKKQLQQ--------LSAWLTLTEERIQKMETCPLDD--------DVKS 455

Query: 6129 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6188
            +   +E+     S+L    E + +    H     ++ +G          E   A+ + QL
Sbjct: 456  LQKLLEEHKSLQSDLEA--EQVKVNSLTHMVVIVDENSG----------ESATAILEDQL 503

Query: 6189 NMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLL 6248
               G                    + W A  R  WT++R + LQ+   L QEL E++ LL
Sbjct: 504  QKLG--------------------ERWTAVCR--WTEERWNRLQEINILWQELLEEQCLL 541

Query: 6249 RSVASRGEEILIQHSAAETSGDAGEKP--------DVLSQELGMEGEKSSAEDQMRMKWE 6300
            ++  +  EE L   +  +TS    +K          +L +++ M+ +      ++     
Sbjct: 542  KAWLTEKEEAL---NKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVG 598

Query: 6301 SLHQEFSTKQKLLQNVLEQEQE-----QVLYSRPNRLLSGVP-LYKGDVPTQDKSAVTSL 6354
             L       +K+  +  E  Q      Q L    N++   V  L    +P +D      +
Sbjct: 599  QLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRV 658

Query: 6355 LDGLNQAFEEVSSQS----GGAKRQSIHLE---QKLYDGVSATS-TWLDDVEERLFVATA 6406
             +   QA  + S Q        K++ IH++   +K +D +SA    W+  ++ +  + T 
Sbjct: 659  RE---QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI--LKWKTAIQTT 713

Query: 6407 LLPE-----ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL 6461
             + E     +T       + L K+ +E     D+  N   Q   E      +  + +  +
Sbjct: 714  EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADE-LNQTGQILVEQMGKEGLPTEEIKNV 772

Query: 6462 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAE 6521
            L ++S     V+Q    ++ ++Q     Q D+   F  L + + +I  K   V    ++E
Sbjct: 773  LEKVSSEWKNVSQHLEDLERKIQ----LQEDINAYFKQLDELEKVIKTKEEWVKHTSISE 828

Query: 6522 QI-EAIQQAEDGLKEFDAGI------IELKRRGDKLQVEQPSMQEL-----SKLQDMYDE 6569
               +++   +D  +     +      IE+ R      + QPS  +            Y  
Sbjct: 829  SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQA 888

Query: 6570 LMMIIGSRRSGLNQNLTLKSQ----YERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 6625
            +   +  R+  L   L  K Q    Y   L+ L D+L   + K      ++ +   ++++
Sbjct: 889  VQEAVEDRQQHLENEL--KGQPGHAYLETLKTLKDVLNDSENKAQVSLNVL-NDLAKVEK 945

Query: 6626 LLDKHKEYFQGLES-----HMILTET-LFRKIISFAVQK-ETQFHTELMAQASAVLKRAH 6678
             L + K   + LE+     H +  ET    K +   V+K   Q   ++  + + +     
Sbjct: 946  ALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS 1005

Query: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENE---DRLIDRITLY--- 6732
            K    LE I  T    + D   + + ++ V+  +      + ++    R +D+ + +   
Sbjct: 1006 KDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNE 1065

Query: 6733 -QHLKSSLN---EYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 6788
             + ++SSL    E +  L      G +  +     D ++QL +L +   +  +++S+   
Sbjct: 1066 IETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQE 1125

Query: 6789 RLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSK 6847
            +   + K       + A++  W+  A++  E+  +      P+ELE   + +      +K
Sbjct: 1126 KAANLKK-------DLAEMQEWMTQAEE--EYLERDFEYKSPEELESAVEEMKR----AK 1172

Query: 6848 EVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
            E   Q  ++  +L    +LL  K       L SEL+ +   +  L   I      L ++ 
Sbjct: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232

Query: 6907 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID--INCKQ 6964
               +   H +    +W++ +E  ++  E   + +       E L+       D     ++
Sbjct: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRE 1292

Query: 6965 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 7024
            L    ++  +L     D+ S         E+L A N  ++ L  L   K   LE  L+  
Sbjct: 1293 LGQTLIDGGILD----DIIS---------EKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339

Query: 7025 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7084
             E +  +Q L+      +K+L     + D+       ++ Q ++  I A E  +E++ +N
Sbjct: 1340 RETDQMLQVLQESLGELDKQLTTY--LTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397

Query: 7085 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7144
                   + + ++S    T R             G    +L+  L + S+    F K  +
Sbjct: 1398 ------MRSQPLTSPESRTARG------------GSQMDVLQRKLREVSTKFQLFQKPAN 1439

Query: 7145 Y---LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
            +   +++ +  L   +     L+   V  D +Q   D   K  ++L +       ++K  
Sbjct: 1440 FEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTG 1499

Query: 7202 HPPVTETLTNT-------LKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST 7254
               V +  T+        L  + + +N+L  ++ E  Q  +   QL ++ K   K+ AS 
Sbjct: 1500 RHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMK---KEAASL 1556

Query: 7255 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
             +       EL++ +T++ +  D + T I    ++LK L   K  L  + E    L+  +
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGD-LDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615

Query: 7315 DASAASAIQSDQLSLSQHLCALEQALCKQQT-------SLQAGVLDYETFAKSLEALEAW 7367
            + S        +  L + LC L     + +T       +L       E F  ++  +  W
Sbjct: 1616 EGS--------EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTW 1667

Query: 7368 IVEAEEILQGQDPSHSSDLSTIQERM-EELKGQMLKFSSMAPD-LDRLNELGYRLPLNDK 7425
            + +AE +L   +   +S    I +R+  EL    L+  ++    L  +N  G     + +
Sbjct: 1668 LYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGS----SSR 1723

Query: 7426 EI--KRMQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7482
            E+   ++  LNR++  +S    + +    Q  L Q     E  ET + F     +KL  +
Sbjct: 1724 ELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPF--SDLEKLEND 1781

Query: 7483 ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTLLS 7541
            I  N    +E+         +M      +  ++  G+ +L Q   D++ E   L+L LL 
Sbjct: 1782 IE-NMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840

Query: 7542 NQWQGV--IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 7599
             ++  +  I   Q++ G + S IR      +   ++ K L+ +  + +S    + +P + 
Sbjct: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS----LNVP-EL 1895

Query: 7600 ARTLFDEVQFKE------KVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQE 7652
               ++++  F+E      K  L + G  I  +   +  ++   SG EA  ++  L ++  
Sbjct: 1896 NTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNA 1955

Query: 7653 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSL-PDHHEELHAEQ 7711
            KW   +    ++K      +++W +    + D  + +   ++ L  +  P    +L   +
Sbjct: 1956 KWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKAR 2015

Query: 7712 MRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7771
            +  +ELE  + S       L+   D +   +S  D S L E++  L ++W+ +  ++  R
Sbjct: 2016 IHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDR 2075

Query: 7772 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQE 7831
            + ++     +   +  +  E+  WLT+ E  + +     + E +++L +D  +E+ +  E
Sbjct: 2076 QPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVHAE 2134

Query: 7832 -----NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK------- 7879
                 N+ +L+ + ++        K SE    L  VN  W  +   +   +K+       
Sbjct: 2135 KLKWLNRTELEMLSDKSLSLPERDKISE---SLRTVNMTWNKICREVPTTLKECIQEPSS 2191

Query: 7880 LKETLVAVQ-----------------------------QLDKNMSSLRTWLAHIESELAK 7910
            + +T +A                                LDK ++ L  WL  I+  L  
Sbjct: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251

Query: 7911 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7970
             IV    + EEI + ++  +  + D+E+    +  V  L + L +   A ++D    +I 
Sbjct: 2252 NIVTVG-DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN--KASSSDMR-TAIT 2307

Query: 7971 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER-TAAFPSSSG 8029
            +    +  +W         R+ ++E+        + D  +++D  + +E     + +   
Sbjct: 2308 EKLERVKNQWDGTQHGVELRQQQLED-------MIIDSLQWDDHREETEELMRKYEARLY 2360

Query: 8030 VIYTVAKEELKKFEAFQRQVHECLTQ--------LELINKQYRRLARENRTDSACSLKQM 8081
            ++    ++ L K    Q   ++ L Q        +   +   ++L  E  +D   ++K+ 
Sbjct: 2361 ILQQARRDPLTK----QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416

Query: 8082 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--E 8139
                   W NL++ +      L+      +      ++ L W+ E +  +  +   S  E
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476

Query: 8140 CDVQAKI--KQLKAFQQEISLN---HNKIEQIIAQGEQLIEKS--EPLDAAIIEEELDEL 8192
              +Q  I  ++LK   Q+I      HN I + I    Q + K+     +A +++  LD++
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536

Query: 8193 RRYCQEVFGR-----------VERYHKKLIRLPLPDDEHDLSDRELELE-----DSAALS 8236
             +   ++  +            E++++ L+ L       ++ D EL+ +     D  AL 
Sbjct: 2537 NQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQ 2596

Query: 8237 DLHWHDRSADSLLSPQPSSNLS------LSLA-QPLRS-ERSGRDTPASVDSIPLEWDHD 8288
              + H ++    L  +  S L+      + LA QP+ + E   R+  +  +  P      
Sbjct: 2597 LQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTP------ 2650

Query: 8289 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQ 8348
                 +    +++A+  +  E ++  +                  ++R L  A+DD    
Sbjct: 2651 ----EERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDAD 2706

Query: 8349 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 8408
            +++ E++     P G  L  S + +++ +      I  +   + K   +  S    ++LH
Sbjct: 2707 MKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPI-NFKVKTVNDLSSQLSPLDLH 2765

Query: 8409 STETQTAGVID---RWELLQAQALSKELRMKQNLQKWQQF 8445
             +   +  + D   RW+LLQ   +S + R+KQ  +  + F
Sbjct: 2766 PSLKMSRQLDDLNMRWKLLQ---VSVDDRLKQLQEAHRDF 2802



 Score =  142 bits (359), Expect = 1e-32
 Identities = 486/2653 (18%), Positives = 1001/2653 (37%), Gaps = 373/2653 (14%)

Query: 5376 KMAEEQKEKYLGLYTILP--------SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATS 5427
            K  +E +E+ + + +  P        +E    + EV +DL   D  Q  ++EV     ++
Sbjct: 272  KYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDL---DSYQIALEEVLTWLLSA 328

Query: 5428 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFL 5487
            ++  ++   ++ D+  +  +       +++    Q  +G  L   N  + +   + ++  
Sbjct: 329  EDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEF 388

Query: 5488 EQNGQLGKPLAKKIGKLTELHQQTIR-QAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
            E   Q+          L     + +R ++ +R S+L+     L++  + L+ +  W+   
Sbjct: 389  EIQEQM---------TLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWL--- 434

Query: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--------- 5597
              L    I       L +     Q LLEE K + S+LEA   K+  LT +          
Sbjct: 435  -TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGE 493

Query: 5598 -CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5656
              T  +  Q+ +LG     + +  + R   LQ+     ++   E   L+A L + +  L 
Sbjct: 494  SATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALN 553

Query: 5657 SPEVGRLSLKEQLS---HRQHLLSEMESLKPKV--QAVQLCQSALRIPEDVVASLPLCHA 5711
              +      +++LS    R  +L E   +K +   Q  ++ Q   ++ ++  AS  +   
Sbjct: 554  KVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSD 613

Query: 5712 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI 5771
            +  L +    L        N +  AV +    +   K L + +      + ++ +   + 
Sbjct: 614  SEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR-----VREQAITKKSK 668

Query: 5772 QEL-------QAQISRHEELAQKIKGYQEQIAS--LNSKCKMLTMKAKHATMLLTVTEVE 5822
            QEL       + QI    E  +K      ++ +  L  K  + T + K    +   +E++
Sbjct: 669  QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMK 728

Query: 5823 GLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSP 5882
               +  E    E +P            A   +     + E+ G+EG  +E       +  
Sbjct: 729  KKLKALEKEQRERIPR-----------ADELNQTGQILVEQMGKEGLPTEEIKNVLEKVS 777

Query: 5883 SPVANTDA---------SVNQDI-AYYQALSA--ERLQTDAAKI-HPSTSASQEFYEPGL 5929
            S   N             + +DI AY++ L    + ++T    + H S S S     P L
Sbjct: 778  SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837

Query: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ----SISTKMEAIELK 5985
            + S   +L +L      +     E  R    AL  Q    D +Q    S   + +A++  
Sbjct: 838  KDSCQRELTNLLGLHPKI-----EMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEA 892

Query: 5986 LSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 6045
            + +  +   +       H A ++ +  L+D +N+ ++     L   +  A   + L  + 
Sbjct: 893  VEDRQQHLENELKGQPGH-AYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKK 951

Query: 6046 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ---------------------- 6083
            TL  + E       K + + + LE+ ++  +E+  +++                      
Sbjct: 952  TLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLL 1011

Query: 6084 -----ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6138
                  L+ +  ++  ++ W+   K  L    +   +   ++ QL  C   + EIE    
Sbjct: 1012 EEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIES 1071

Query: 6139 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKE 6198
            +L  +     NL     A  K   +   G  +     L +L + +  ++  +  + ++  
Sbjct: 1072 SLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQT---QLEKLSKEIATQKSRLSESQEKAA 1128

Query: 6199 ESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEI 6258
                DL       +QEW+ QA   + + R    +  +ELE  + E K     V  +   +
Sbjct: 1129 NLKKDLAE-----MQEWMTQAEEEYLE-RDFEYKSPEELESAVEEMKRAKEDVLQKEVRV 1182

Query: 6259 -LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQMRMKWESLHQEFSTKQKLLQ-- 6314
             +++ +    +         L+ EL +  E      +++R K  +L + +S   +LL   
Sbjct: 1183 KILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYL 1242

Query: 6315 -------NVLEQEQE--QVLYSRPNRL------LSGVPLYKGDVPTQDKSAVTSLLDG-- 6357
                   N LE+  +  +VL  + + +      L  V  +  D  TQ +    +L+DG  
Sbjct: 1243 DLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGI 1302

Query: 6358 -----------LNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVA-- 6404
                        N  +E++S     A+ + I LE++L   +  T   L  ++E L     
Sbjct: 1303 LDDIISEKLEAFNSRYEDLSHL---AESKQISLEKQL-QVLRETDQMLQVLQESLGELDK 1358

Query: 6405 --TALLPEETETCLFNQEILAKDIKEMSEEM---DKNKNLFSQAF--PEN-----GDNRD 6452
              T  L +  +     QE      +  + E+   +  +N+ SQ    PE+     G   D
Sbjct: 1359 QLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMD 1418

Query: 6453 VIEDTLGCLLGRLSLLDSVVN--QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
            V++  L  +  +  L     N  QR    K  L  +   + +L VL     D        
Sbjct: 1419 VLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGV---KAELHVLDVKDVD-------- 1467

Query: 6511 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSM--QELSKLQDMYD 6568
              +V +  + + ++  +   +   E +  I   +    K Q + P    ++L+ L+ +Y+
Sbjct: 1468 -PDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYN 1526

Query: 6569 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ---------EKMAGDQKIIVSS 6619
            +L   +   +  L +   L  + ++    L++ L   +         E + GD    +S 
Sbjct: 1527 DLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISW 1586

Query: 6620 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6679
             + + + L+K K           +TE+      S A+Q   +    ++ +   VL     
Sbjct: 1587 AKNVLKDLEKRKADLN------TITES------SAALQNLIEGSEPILEERLCVLNAGWS 1634

Query: 6680 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT--------- 6730
            R   +    E W +   + Q    QLE+ + ++  +       + L+D I          
Sbjct: 1635 R---VRTWTEDWCNTLMNHQN---QLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEE 1688

Query: 6731 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRL 6790
            + + L S L++   ++  V D    L+ +   S  E    +L E    N  K+S+ +   
Sbjct: 1689 IVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAEL-NRNFEKVSQHIKSA 1747

Query: 6791 ETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT--VPQELEMVRDHLNAFLEFSKE 6848
            + ++     YQ      +   ++ +  + F   + +   +   L+ V  HL +  E  K 
Sbjct: 1748 KLLIAQEPLYQC-----LVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEK- 1801

Query: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
            +D +S+    VL  G ++L     D     +R +L  + +++  +   IP  Q K+ QL 
Sbjct: 1802 MDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKA-IPIQQRKMGQL- 1859

Query: 6907 MDKLPSRHAISEVMSWISLME-NVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI--NCK 6963
                 +    S ++    L+E N I    D+++ S+    ++  + +   F+ D   N K
Sbjct: 1860 -----ASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIK 1914

Query: 6964 QLTVDFVNQSVLQISSQD----VESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEG 7019
               +D + + +  I  +     +E+   +     + L  +N  W  +  + +++    + 
Sbjct: 1915 D-QLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDR 1973

Query: 7020 LLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7079
             +E W ++  ++  L  W    E+ L      G    ++ A    Q+LE  I + +    
Sbjct: 1974 AMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFA 2033

Query: 7080 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7139
             + + G  ++Q   +   S +   L  L Q W  +   V   +  LK    Q   ++   
Sbjct: 2034 ALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQL 2093

Query: 7140 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL- 7198
            D+I  +L +A +++ +         +     +NLQ L+D  ++ E   +K   +    L 
Sbjct: 2094 DEIICWLTKAEHAMQK--------RSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELE 2145

Query: 7199 ----KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ---------SSKALLQLWQRYK 7245
                K    P  + ++ +L+ VNM WN +  E+   L+         S   +       K
Sbjct: 2146 MLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQK 2205

Query: 7246 DYSKQCASTVQQQEDRTNEL-LKAATNKDIADDEVATWIQDCNDLLKG----LGTVKD-- 7298
                  AS +  Q  RT+E+ + A  +K I   E+A W+   + +LK     +G V++  
Sbjct: 2206 VVLVSSASDIPVQSHRTSEISIPADLDKTIT--ELADWLVLIDQMLKSNIVTVGDVEEIN 2263

Query: 7299 ------------------SLFFLHELGEQLKQQVDASAASAIQSDQLS-LSQHLCALEQA 7339
                               L ++  L + LK +  +S      +++L  +       +  
Sbjct: 2264 KTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHG 2323

Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL----QGQDPSHSSDLSTIQERMEE 7395
            +  +Q  L+  ++D   +    E  E  + + E  L    Q +    +  +S  Q  ++E
Sbjct: 2324 VELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQE 2383

Query: 7396 L---KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 7452
            L    G ++ F ++   L  L E G     N KE    + L   W  +     +R + L+
Sbjct: 2384 LGPGDGIVMAFDNVLQKL--LEEYGSDDTRNVKE--TTEYLKTSWINLKQSIADRQNALE 2439

Query: 7453 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQH--LLEQQRAHEL------FQAEM 7504
            +     Q      E +++++ + E  + V +  +++   L +   A EL       QAE+
Sbjct: 2440 AEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEI 2499

Query: 7505 FSRQQILHSIIIDGQRLLEQ-GQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7563
             +   I  SI  + Q++++  G  ++      +L  ++ +W  +  ++   R  +++   
Sbjct: 2500 DAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAE 2559

Query: 7564 QWQRYREMAEKLRKWL-----VEVSYLPMSG-LGSVPIPLQQARTLFDEVQFKE------ 7611
            +W R     E+L KWL          +P+ G + ++ +     + L  E++ KE      
Sbjct: 2560 KWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNA 2619

Query: 7612 ----KVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKK 7667
                +VFL  Q      +EA ++   +  S  E   +    +I +  +  S  ++E+ + 
Sbjct: 2620 VDQARVFLADQ-----PIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES 2674

Query: 7668 LAFLLKDWEKCEKGIADSLEKLRTFK------------------------KKLSQSLPDH 7703
            L  +  +W   +K +  +LEKLR  +                          L  SL DH
Sbjct: 2675 LNAVTSNW---QKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDH 2731

Query: 7704 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7763
             E++ A +     +   V +  D  +QLS L D   +   +  +  LN R +LLQ   ++
Sbjct: 2732 IEKIMAFREEIAPINFKVKTVNDLSSQLSPL-DLHPSLKMSRQLDDLNMRWKLLQVSVDD 2790

Query: 7764 LCHQLSLRRQQIG 7776
               QL    +  G
Sbjct: 2791 RLKQLQEAHRDFG 2803



 Score =  130 bits (326), Expect = 8e-29
 Identities = 481/2684 (17%), Positives = 1061/2684 (39%), Gaps = 376/2684 (14%)

Query: 3587 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHE 3646
            +ET +    V   L   +   ++V  WL +AE+    +     +    + Q    + +  
Sbjct: 298  AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357

Query: 3647 EVTAYRDEVEEVGARAQEILDESHVNSR----MGCQATQLTSRYQALLLQVLEQIKFLEE 3702
            E+TA++  V  V     +++ +  ++      +  Q T L +R++AL ++ +++   L +
Sbjct: 358  ELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHD 417

Query: 3703 EIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS 3762
             +  L++ +  L   S W   T +       +I K++T  +   +K+L+ LL++ +   S
Sbjct: 418  VLMELQKKQ--LQQLSAWLTLTEE-------RIQKMETCPLDDDVKSLQKLLEEHKSLQS 468

Query: 3763 LLKSAREKGE---RAVKYLEEGEAERLRKEIHDHMEQLKELTSTV----RKEHMTLEKGL 3815
             L++ + K       V  ++E   E     + D +++L E  + V     +    L++  
Sbjct: 469  DLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEIN 528

Query: 3816 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3875
             L +E  ++   L  W+ E +E L+            K Q S +K  ++  +S       
Sbjct: 529  ILWQELLEEQCLLKAWLTEKEEALN------------KVQTSNFKDQKELSVS------- 569

Query: 3876 VREKGEALLELVQDVTLKDK-IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEV 3934
            VR     L  L +D+ +K + +DQL    QD        V  L    K  +  NS+ +E+
Sbjct: 570  VRR----LAILKEDMEMKRQTLDQLSEIGQD--------VGQLLDNSKASKKINSDSEEL 617

Query: 3935 -EKW--LLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI 3991
             ++W  L+Q          LE SS + +TQ +A  K  M +I   +D L  ++++   + 
Sbjct: 618  TQRWDSLVQR---------LEDSSNQ-VTQAVA--KLGMSQIPQ-KDLLETVRVREQAIT 664

Query: 3992 GQCADHLQAK---LKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 4048
             +    L       K+ +H  ++            A++ + ++  EL   + +       
Sbjct: 665  KKSKQELPPPPPPKKRQIHVDIE------------AKKKFDAISAELLNWILK------- 705

Query: 4049 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4108
              W +A+Q       +  +   +  +  K  +AL+++ R  +     +       V+   
Sbjct: 706  --WKTAIQTT---EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG 760

Query: 4109 KDIQQTEQ---TIEQKLVQAQNLTQGWEEIKH---LKSELWIYLQDADQQLQNMKRR--- 4159
            K+   TE+    +E+   + +N++Q  E+++    L+ ++  Y +  D+  + +K +   
Sbjct: 761  KEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEW 820

Query: 4160 --HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKV----NKLTKKEESPEHKEINH 4213
              H+ +  +  Q++ S +KD  ++  +    ++  IE      + L  +  +P+  +   
Sbjct: 821  VKHTSISESSRQSLPS-LKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGF 879

Query: 4214 LNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSD--AEST 4271
              D +L   +        R++ L+              +LE   T  D L  S+  A+ +
Sbjct: 880  --DSFLGRYQAVQEAVEDRQQHLENELKGQPG----HAYLETLKTLKDVLNDSENKAQVS 933

Query: 4272 AVHLEALKKLALALQERKYAIEDLKDQK----------QKMIEHLNLDDKELVKEQTSHL 4321
               L  L K+  ALQE+K   E L++QK          + + ++++ D ++L K++   +
Sbjct: 934  LNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDV 993

Query: 4322 EQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL--KQSPPPDM 4379
            + +W +L+ L+ + + +    LEE+ +    F+      E+    + + L  +Q+   D 
Sbjct: 994  QGKWNKLKVLVSKDLHL----LEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDD 1049

Query: 4380 A--QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCL 4437
            A  Q  L    A  +E+E  +  LK++ +    + +      +  +Q  L D Q+ +  L
Sbjct: 1050 AGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKL 1109

Query: 4438 SDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
            S  +  ++  L+++  +       + +    + Q E + + R+     P+++   V+  K
Sbjct: 1110 SKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMK 1169

Query: 4498 SAQASLKTYQNEVTGLWAQGRELMKEVT---EQEKSEVLGKLQELQSVYDSVLQKCSHRL 4554
             A+  +   +  V  L    + L  +V    ++  SE+   L+  Q + + +  KC H L
Sbjct: 1170 RAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKC-HTL 1228

Query: 4555 QELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPE 4614
            +E+    +   H+    D    WL   +        L  ++  ++  L   +++L    +
Sbjct: 1229 EEVWSCWIELLHY---LDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPAD 1285

Query: 4615 YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARK 4674
                   ++  GQT++     +    +SEKL A   ++  +  LA+ K   +++ +   +
Sbjct: 1286 NRT---QIRELGQTLID--GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLR 1340

Query: 4675 EYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            E   ++++  +SL EL+ Q   ++   TD    +A  +    + I  E++     ++EL 
Sbjct: 1341 ETDQMLQVLQESLGELDKQ---LTTYLTDRI--DAFQVPQEAQKIQAEISAHELTLEELR 1395

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL---- 4790
            +       T    +  +    + +  R  R+   +  L +   + +++    C+++    
Sbjct: 1396 RNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPAN-FEQRMLDCKRVLDGV 1454

Query: 4791 --ERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
              E  +  VK+    V +  L  ++ +K+Y +L+    +   V+K    H+       +P
Sbjct: 1455 KAELHVLDVKDVDPDVIQTHL--DKCMKLYKTLSEVKLEVETVIK-TGRHIVQKQQTDNP 1511

Query: 4849 LAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSL----DWLRRVK 4904
               ++   Q+ S    LK+L + +G  VTE +  + ++     +M +      +WL   +
Sbjct: 1512 KGMDE---QLTS----LKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATE 1564

Query: 4905 AELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-- 4962
             EL      +  L D+  EI   +   ++++     +N ++    E     + LI     
Sbjct: 1565 TELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTIT----ESSAALQNLIEGSEP 1620

Query: 4963 -LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 5021
             LE  L  L+     ++        TL    +Q + +       + WL  A+ LL    +
Sbjct: 1621 ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALL----D 1676

Query: 5022 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5081
             ++ +   +  +      S  D  +  +E +      L      + +E +E K+A L   
Sbjct: 1677 EIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRN 1736

Query: 5082 SQRMSRDSG------AQVDLLQ-RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSS 5134
             +++S+         AQ  L Q   T +  +      ++ +L ND E  L    + K   
Sbjct: 1737 FEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLK--FVEKHLE 1794

Query: 5135 SHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTR 5194
            S + +EK+ E  A +  V         L+     L +   D  K  +   +  +  R+ +
Sbjct: 1795 SSDEDEKMDEESAQIEEV---------LQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNK 1845

Query: 5195 LRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYH 5254
            ++A+   Q K+ + A    +G  + +     +++  +  L     E +     L    Y 
Sbjct: 1846 IKAIPIQQRKMGQLA----SGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYE 1901

Query: 5255 DTFVLE---------LEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5305
            D    E         L++    + ++ ++   ++ + + P   +    + ++ A  DR  
Sbjct: 1902 DFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRIN 1961

Query: 5306 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP-----TIEIDAQLEEL 5360
             M    K       + +++       +N +  W+ E +E L +      +++++      
Sbjct: 1962 RMYSDRK---GCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQ 2018

Query: 5361 QILLTEATNHRQN-----------IEKMAEEQ----KEKYLGL---YTILPSELSLQ--- 5399
            Q L    ++H+ +           ++K+++      KEK  GL   +  + +E+  +   
Sbjct: 2019 QELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPR 2078

Query: 5400 -LAEVALDLKIRDQIQDKI-----KEVEQSKATSQELSRQIQKLAKDLTTIL----TKLK 5449
               E    +K R Q+ + I      E    K ++ EL   +Q+L +DLT  +     KLK
Sbjct: 2079 LKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVHAEKLK 2137

Query: 5450 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF-----------------LEQNGQ 5492
                  ++  +D+ +   E D  +  L  ++    K                  + Q   
Sbjct: 2138 WLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRI 2197

Query: 5493 LGKPLAKK---IGKLTELHQQTIRQAENRL-SKLNQAASHLEEYNEMLELILK------- 5541
               P  +K   +   +++  Q+ R +E  + + L++  + L ++  +++ +LK       
Sbjct: 2198 AAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVG 2257

Query: 5542 -WIEKAKVLAHGTIAWNSASQLREQ----YILHQTLLEESKEIDSELEAMTEKLQYLTSV 5596
               E  K ++   I      Q   Q    + L Q L  ++   D    A+TEKL+ + + 
Sbjct: 2258 DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMR-TAITEKLERVKNQ 2316

Query: 5597 YCTEKMSQQVAELGRETEELRQMIKIRLQ---NLQDAAKDMKKFEAELKKLQAALEQAQA 5653
            +     +Q   EL    ++L  MI   LQ   + ++  + M+K+EA L  LQ A    + 
Sbjct: 2317 W---DGTQHGVEL--RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQA---RRD 2368

Query: 5654 TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAAL 5713
             LT        L ++L     ++   +++  K+           + E    +  L  + +
Sbjct: 2369 PLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKE---TTEYLKTSWI 2425

Query: 5714 RLQEEASRLQHTAIQQCNIMQAAVVQYEQY----EQEMKHLQQLIEGAHRE--IEDKPVA 5767
             L++  +  Q+    +   +QA+    E +    ++    +  L++ +HRE  ++D  +A
Sbjct: 2426 NLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILA 2485

Query: 5768 ---TSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTM---------------KA 5809
                  +Q++QA+I  H ++ + I G ++++       +  TM               KA
Sbjct: 2486 RELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKA 2545

Query: 5810 KHAT--------------MLLTVTE-VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCH 5854
            K A+              +L+++ E ++ L    E+L  + +P     P+ + +    C 
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQ-MPIGGDVPA-LQLQYDHCK 2603

Query: 5855 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 5914
             L   + E+                     V N   +V+Q   +      E  +     +
Sbjct: 2604 ALRRELKEKE------------------YSVLN---AVDQARVFLADQPIEAPEEPRRNL 2642

Query: 5915 HPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS 5974
               T  + E     +  +   +  +++  WE+L  V S  Q+ + +ALE+ +  Q ++  
Sbjct: 2643 QSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDD 2702

Query: 5975 ISTKMEAIELKLSESPEPGRSPESQMA--EHQALMDEILMLQDEINELQSSL--AEELVS 6030
            +       ++K +ES   G  P   +     Q  +++I+  ++EI  +   +    +L S
Sbjct: 2703 LDA-----DMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSS 2757

Query: 6031 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
            +    D    L +   L  L  R   +++    + + L+E   D
Sbjct: 2758 QLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRD 2801



 Score =  121 bits (303), Expect = 3e-26
 Identities = 499/2775 (17%), Positives = 1038/2775 (37%), Gaps = 365/2775 (13%)

Query: 1233 DCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDV 1292
            D   Y+  ++  L  L+S     QEQ +   D E   E +     H+     ++A +  V
Sbjct: 310  DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVE---EVKDQFATHEAFMMELTAHQSSV 366

Query: 1293 QQQIAQAQQ--GEGGLPDRGHEELRKLESTLDGL-----ERSRERQERRIQVTLRKWERF 1345
               +    Q   +G L D    E+++  + L+         S +RQ R   V +      
Sbjct: 367  GSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM------ 420

Query: 1346 ETNKETVVRYLFQTGSSHERFLSFSS------LESLSSELEQTKEFSKRTESIAVQAENL 1399
            E  K+ + +       + ER     +      ++SL   LE+ K      E+  V+  +L
Sbjct: 421  ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL 480

Query: 1400 VKEASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1457
                  +    G     +L+ Q + + E+   +    EE    ++ +   W         
Sbjct: 481  THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540

Query: 1458 LSVWITEKEKELNALETSS----SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQF 1513
            L  W+TEKE+ LN ++TS+      + + + ++ +  +++E K  ++  L E  Q   Q 
Sbjct: 541  LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600

Query: 1514 VTTGESARI----KAKLTQ-----IRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1564
            +   ++++       +LTQ     ++R  +   +  Q +    +  + Q+   E    + 
Sbjct: 601  LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660

Query: 1565 QQSVSEFEDKLAVP----------------------------IKICSSATETYKVLQEHM 1596
            Q    + + +L  P                            I    +A +T ++ +E+M
Sbjct: 661  QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEI-KEYM 719

Query: 1597 DLCQALESLSSAITAFSASARKVVNR-DSCVQEAAALQQQYEDILRRAKERQTALENLLA 1655
             + Q    +   + A     R+ + R D   Q    L +Q        +E +  LE + +
Sbjct: 720  KM-QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSS 778

Query: 1656 HWQ-------------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQAL 1702
             W+             +L+++++++   L+  E    + E  +    +  E   Q + +L
Sbjct: 779  EWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS-ESSRQSLPSL 837

Query: 1703 ----QNEVVSQASFYSKLLQLKESLFSVASKDDVK-MMKLHLEQLDERWRDLPQIINKRI 1757
                Q E+ +    + K+   + S  ++ S+      ++   +    R++ + + +  R 
Sbjct: 838  KDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQ 897

Query: 1758 NFLQSVVAE---HQQFDEL-------------------LLSFSVWIKLFLSELQTTSEIS 1795
              L++ +     H   + L                   +L+    ++  L E +T  EI 
Sbjct: 898  QHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI- 956

Query: 1796 IMDHQVALTRHKDHAAEVESK---------KGELQSLQGHLAKLGSLGRAEDLHLLQGKA 1846
            + + + AL +  +    +E           K E   +QG   KL  L  ++DLHLL+  A
Sbjct: 957  LENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV-SKDLHLLEEIA 1015

Query: 1847 EDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIE 1906
                + FE  S V+E+    +  + +FL    +  G    L++ ++  ++   NE + IE
Sbjct: 1016 LT-LRAFEADSTVIEKW---MDGVKDFLMKQQAAQGDDAGLQRQLDQCSAF-VNEIETIE 1070

Query: 1907 KDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL 1966
              L +  +    L S  V+  GI  K     ++G  + +       ++L  E+   ++ L
Sbjct: 1071 SSLKNMKEIETNLRSGPVA--GI--KTWVQTRLGDYQTQL------EKLSKEIATQKSRL 1120

Query: 1967 GTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLED 2026
               Q +A   A LKK   + +E + ++ E+  ER  + +  E    A+++  R     ++
Sbjct: 1121 SESQEKA---ANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA----KE 1173

Query: 2027 ELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLID 2086
            ++   E  +  LKD  K +A K  +   E+  E+N   V  ++ + L +  +G+C  L +
Sbjct: 1174 DVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELN---VVLENYQLLCNRIRGKCHTLEE 1230

Query: 2087 L------MREYQNLKSAVSKVLENA--SSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2138
            +      +  Y +L++     LE    S+ ++   T    E L       E+ ++ + + 
Sbjct: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL-------ESLESVLRHP 1283

Query: 2139 QKDLDNFTSKGKHLLS----------ELKKIHS--SDFSLVKTDMESTVDKWLDVSEKLE 2186
              +       G+ L+           +L+  +S   D S +    + +++K L V  + +
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETD 1343

Query: 2187 ENMDRLRVSLSIWDDVLST--RDEIEGWSNNCVPQMAENI-SNLDNH-LRAEELLKEFES 2242
            + +  L+ SL   D  L+T   D I+ +    VPQ A+ I + +  H L  EEL +   S
Sbjct: 1344 QMLQVLQESLGELDKQLTTYLTDRIDAFQ---VPQEAQKIQAEISAHELTLEELRRNMRS 1400

Query: 2243 E-VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKD 2301
            + + +   R     S+++ L+   + + T   L    A+  Q++   K + +  K  L  
Sbjct: 1401 QPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHV 1460

Query: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQS-NISSTQ 2360
               +    +     I T   K  + L         E    +K  +  +Q QQ+ N     
Sbjct: 1461 LDVKDVDPDV----IQTHLDKCMK-LYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMD 1515

Query: 2361 ENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQE 2420
            E L SL   Y+      LG  +T   +  E  SQL  K +            +      E
Sbjct: 1516 EQLTSLKVLYND-----LGAQVTEGKQDLERASQLARKMK------------KEAASLSE 1558

Query: 2421 WFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQ 2480
            W    +    + S   G    L+ ++   +N+L  +   ++ L+ +T+    L  +L + 
Sbjct: 1559 WLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQ-NLIEG 1617

Query: 2481 IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT 2540
                ++E++   N  +             L +  ++L  F+     ++ W+++ E     
Sbjct: 1618 SEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEAL--- 1674

Query: 2541 ENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQ 2600
              L E ++    K+ E+  V+  + EL  A   ++ +  +  +L     G+     +  +
Sbjct: 1675 --LDEIEKKPTSKQEEI--VKRLVSELDDANLQVENVRDQALILMN-ARGSSSRELVEPK 1729

Query: 2601 LLTSHQNL-----------LRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLAC 2649
            L   ++N            L + +E L  C V  +  E        +      I++ L  
Sbjct: 1730 LAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFET-GVPFSDLEKLENDIENMLKF 1788

Query: 2650 AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQT 2705
             E  L S D  EK   +   I  +   GE  L+       Q +  + KE  R+    + T
Sbjct: 1789 VEKHLESSDEDEKMDEESAQIEEVLQRGEEMLH-------QPMEDNKKEKIRLQLLLLHT 1841

Query: 2706 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2765
            +   +K +          A     S++    DY+   N++   M+ V+  +  P +    
Sbjct: 1842 RYNKIKAIPIQQRKMGQLASGIRSSLLP--TDYLVEINKILLCMDDVELSLNVP-ELNTA 1898

Query: 2766 LKEKFVLL-DHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDI 2824
            + E F    D L++I  +       L +L  +   ++EK  D   + +  E +  Q  D 
Sbjct: 1899 IYEDFSFQEDSLKNIKDQ-------LDKLGEQIAVIHEKQPDVILEASGPEAI--QIRDT 1949

Query: 2825 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW----SDMSGDSSATQKKL 2880
            +T    K  ++  +  D     D   E     H    +L +W     ++  D+ A    L
Sbjct: 1950 LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSL 2009

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2940
               K  I  +E+     S   S A     N T  G        +  +AD    ++ +   
Sbjct: 2010 DLEKARIHQQELEVGISSHQPSFAA---LNRTGDGIV-----QKLSQADGSFLKEKLAGL 2061

Query: 2941 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3000
                + +V+++   +    G+  Q+ +   Q   ++  W   LT  E         E   
Sbjct: 2062 NQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEII-CW---LTKAEHAMQKRSTTELGE 2117

Query: 3001 KGQEILDALQKAEPRTEDLK----SQLNELCRFSRDLSTYSGKVSGLIKE----YNCLCL 3052
              QE+ D  Q+ E   E LK    ++L  L   S  L     K+S  ++     +N +C 
Sbjct: 2118 NLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERD-KISESLRTVNMTWNKICR 2176

Query: 3053 QAS---KGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKC-----------FDIPQNIS 3098
            +     K C  +   + Q    A  + Q+ ++ +  +                D+ + I+
Sbjct: 2177 EVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTIT 2236

Query: 3099 EVSTSLQKIQEFLSES--------ENGQHKLNMMLSKGEL---------LSTLLTKEKAK 3141
            E++  L  I + L  +        E  +    M ++K +L         + TL    K K
Sbjct: 2237 ELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNK 2296

Query: 3142 GIQAKV-TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESS 3200
               + + TA  E  +   +     +  +E  + Q++D  + +    D   +TE+++ +  
Sbjct: 2297 ASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYE 2356

Query: 3201 NRLYDLPAKRREQ-----QKLQSVLEEIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHR 3253
             RLY L   RR+         Q +L+E+   +  +       Q+L E  G   +++ +  
Sbjct: 2357 ARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416

Query: 3254 VSQLSSQYLALSNLTKEKVSRLDR----IVAEHNQFSLGIKELQDWMTDAIHMLDSYCHP 3309
               L + ++ L     ++ + L+     + A        +K +Q+  T    ++D+    
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476

Query: 3310 TSDKSVLDSRTLKLEAL---LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV 3366
             + +  + +R LK +       +    +I   +   R + V    + E    +Q +L  +
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536

Query: 3367 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT 3426
               W  L +     ++ LE +  KW      + +   W++  +  L +      ++    
Sbjct: 2537 NQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQ 2596

Query: 3427 TMLGKAKLLNEEVLSYS-SLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEA 3483
                  K L  E+     S+L  ++     + +  +   E   ++LQ +     E   + 
Sbjct: 2597 LQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQK 2656

Query: 3484 VTKS--EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVH 3541
            + K+  ++   + ++++        W  Q  + L++   L+G     +  +++ + ++  
Sbjct: 2657 IAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNG 2716

Query: 3542 CAE-GQALLNS-------VLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
                G  L++S       ++  RE++ P          L S         H   +   Q 
Sbjct: 2717 WKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL--HPSLKMSRQL 2774

Query: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQL-HQMKKWHEEVTAYR 3652
            +++  + +L++     VD+ LK  +E          +  +  +QL  Q    H +V  Y 
Sbjct: 2775 DDLNMRWKLLQ---VSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYI 2831

Query: 3653 D--------EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLE--- 3701
            +        +  ++    Q + D ++V       A ++    +AL L +LE     E   
Sbjct: 2832 NHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFK 2891

Query: 3702 -------EEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK--------VDTVMMGK- 3745
                   +++ S+ +  + L++  D     HK+  NV   +D          DT   GK 
Sbjct: 2892 QHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKI 2951

Query: 3746 KLKTLEVLLKDMEKG 3760
            ++++L++ L  + KG
Sbjct: 2952 RVQSLKIGLMSLSKG 2966



 Score =  114 bits (285), Expect = 4e-24
 Identities = 480/2732 (17%), Positives = 1041/2732 (38%), Gaps = 482/2732 (17%)

Query: 6235 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-DVLSQELGMEGEKS---S 6290
            ++ ++E  E+   ++S A   E    +   AET     E   D+ S ++ +E   +   S
Sbjct: 271  RKYKKECEEEAINIQSTAPEEEH---ESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLS 327

Query: 6291 AEDQMRMK------WESLHQEFSTKQKLLQNVL-EQEQEQVLYSRPNRLLSGVPLYKGDV 6343
            AED  + +       E +  +F+T +  +  +   Q     +    N+L++     +G +
Sbjct: 328  AEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLIT-----QGTL 382

Query: 6344 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS------IHLEQKLYDGVSATSTWLDDV 6397
              +++  +   +  LN  +E +  +S    RQS      + L++K    +SA   WL   
Sbjct: 383  SDEEEFEIQEQMTLLNARWEALRVES--MDRQSRLHDVLMELQKKQLQQLSA---WLTLT 437

Query: 6398 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE----NGDNRDV 6453
            EER+        ++ ETC  +      D+K + + ++++K+L S    E    N     V
Sbjct: 438  EERI--------QKMETCPLDD-----DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV 484

Query: 6454 I-------EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI 6506
            +       E     L  +L  L       C   +ER  ++     ++ +L+  L + + +
Sbjct: 485  VIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL----QEINILWQELLEEQCL 540

Query: 6507 ILQKLANVFEQPVAEQIEAIQQAEDG----LKEFDAGIIELKRRGDKLQVEQPSMQELSK 6562
            +   L         E+ EA+ + +       KE    +  L    + +++++ ++ +LS+
Sbjct: 541  LKAWLT--------EKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE 592

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
            +     +L+    + +   + +  L  +++  +Q L D      + +A      +  K+ 
Sbjct: 593  IGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDL 652

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            ++ +  + +   +  +  +       ++ I   ++ + +F        + +LK   K  +
Sbjct: 653  LETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK--WKTAI 710

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESS----IPSVGLVEENEDRLIDRITLYQHLKSS 6738
            +   I E      +D  E+ ++L+ +E      IP    + +    L++++      K  
Sbjct: 711  QTTEIKEYMKM--QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG-----KEG 763

Query: 6739 L--NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK- 6795
            L   E +  L +V  + K   +S    DLE ++ QL E    + N   K+L  LE ++K 
Sbjct: 764  LPTEEIKNVLEKVSSEWKN--VSQHLEDLERKI-QLQE----DINAYFKQLDELEKVIKT 816

Query: 6796 --HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQS 6853
               W ++ S S      L S KD  +      + +  ++EM R   +A +      D   
Sbjct: 817  KEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQ 876

Query: 6854 SLKSSVLSTGNQLLRLKKVDTATLRSELS-RIDSQWTDLLTNIPAV---QEKLHQLQMDK 6909
                S L     +    +     L +EL  +    + + L  +  V    E   Q+ ++ 
Sbjct: 877  RGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV 936

Query: 6910 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 6969
            L     + + +     ++ +++  +          A+H+  ++ K  + +++        
Sbjct: 937  LNDLAKVEKALQEKKTLDEILENQKP---------ALHKLAEETKALEKNVH-------- 979

Query: 6970 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 7029
                       DVE  +  K +F +  G  NK    L+ LV++ + LLE +  +   +E 
Sbjct: 980  ----------PDVE--KLYKQEFDDVQGKWNK----LKVLVSKDLHLLEEIALTLRAFEA 1023

Query: 7030 NVQCLKTWFE-TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7088
            +   ++ W +  ++  +KQQ   GD A +Q  L  C    + I+  E  ++ +++    L
Sbjct: 1024 DSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNL 1083

Query: 7089 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7148
                   + + V + L +       L   +   K  L    ++ ++ K    ++  ++ +
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143

Query: 7149 ARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD-LEKQERS--------------------- 7186
            A            S E ++  V+ ++  ++D L+K+ R                      
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203

Query: 7187 -------LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLE----------EIAE 7229
                   L+ +  + N++  +CH         TL+EV   W  LL            + E
Sbjct: 1204 TSELNVVLENYQLLCNRIRGKCH---------TLEEVWSCWIELLHYLDLETTWLNTLEE 1254

Query: 7230 QLQSSKALLQLWQRYKDYSKQCASTVQQQED---RTNELLKAATNKDIADDEVATWIQDC 7286
            +++S++ L +      +  +   S ++   D   +  EL +   +  I DD ++  ++  
Sbjct: 1255 RMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAF 1314

Query: 7287 NDLLKGLG--------TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE- 7337
            N   + L         +++  L  L E  +Q+ Q +  S     +     L+  + A + 
Sbjct: 1315 NSRYEDLSHLAESKQISLEKQLQVLRET-DQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373

Query: 7338 -QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE--------EILQGQDPSHSSDLST 7388
             Q   K Q  + A  L  E   +++ +      E+         ++LQ +    S+    
Sbjct: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433

Query: 7389 IQ------ERMEELKG---------QMLKFSSMAPD-----LDRLNELGYRLPLNDKEIK 7428
             Q      +RM + K           +L    + PD     LD+  +L   L     E++
Sbjct: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVE 1493

Query: 7429 RMQNLNRHWSLISSQTTER--------------FSKLQSFLLQHQTFLEKCETWMEFLVQ 7474
             +    RH  ++  Q T+               ++ L + + + +  LE+       + +
Sbjct: 1494 TVIKTGRH--IVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKK 1551

Query: 7475 TEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN 7534
                L+  +S     L+++  +  L   ++ +      +++ D    LE+ + D  +   
Sbjct: 1552 EAASLSEWLSATETELVQKSTSEGLL-GDLDTEISWAKNVLKD----LEKRKAD-LNTIT 1605

Query: 7535 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE-VSYLPM--SGLG 7591
                 L N  +G     ++R  ++++    W R R   E     L+   + L +    + 
Sbjct: 1606 ESSAALQNLIEGSEPILEERLCVLNAG---WSRVRTWTEDWCNTLMNHQNQLEIFDGNVA 1662

Query: 7592 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE----L 7647
             +   L QA  L DE++  +K   +Q+       E  K+L+   D   +A LQ E     
Sbjct: 1663 HISTWLYQAEALLDEIE--KKPTSKQE-------EIVKRLVSELD---DANLQVENVRDQ 1710

Query: 7648 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE-E 7706
            A I    + +S R E  + KLA L +++EK  + I  +  KL   ++ L Q L      E
Sbjct: 1711 ALILMNARGSSSR-ELVEPKLAELNRNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETFE 1767

Query: 7707 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE---RVELLQRQWEE 7763
                    ++LEN + +         +LK       S+D+   ++E   ++E + ++ EE
Sbjct: 1768 TGVPFSDLEKLENDIEN---------MLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEE 1818

Query: 7764 LCHQ---------LSLRRQQIGERLNEWAVFSEKNKEL-------------CEWLTQMES 7801
            + HQ         + L+   +  R N+      + +++              ++L ++  
Sbjct: 1819 MLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINK 1878

Query: 7802 KVSQNGDILIEEMIEKLKKDYQEEIAIAQEN----KIQLQQMGERLAKASHESK------ 7851
             +    D+ +   + +L     E+ +  +++    K QL ++GE++A   HE +      
Sbjct: 1879 ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA-VIHEKQPDVILE 1937

Query: 7852 -----ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7906
                 A +I   L ++N +W  +  + + R       +   +Q   +++ L  W+   E 
Sbjct: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997

Query: 7907 ELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7963
                 ++ D+C    S ++++    QQEL+  I  H    A++    + ++       + 
Sbjct: 1998 -----LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL----SQ 2048

Query: 7964 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 8023
            A+   +++    L++RW  I A   +R+ +++   +   K+         WL  +E    
Sbjct: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108

Query: 8024 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL----- 8078
              S+     T   E L++     +++     +L+ +N    R   E  +D + SL     
Sbjct: 2109 KRST-----TELGENLQELRDLTQEMEVHAEKLKWLN----RTELEMLSDKSLSLPERDK 2159

Query: 8079 -KQMVHEGNQRWDNLQKRVTSILRRL-------------KHFIGQREEFETARDSILV-- 8122
              + +   N  W+ + + V + L+                H   Q+    ++   I V  
Sbjct: 2160 ISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219

Query: 8123 ---------------------WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLN 8159
                                 WL  +D  L +NI    + + +   + ++K  + ++   
Sbjct: 2220 HRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQR 2279

Query: 8160 HNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD- 8217
            H +++ +    + L  K+   D    I E+L+ ++         VE   ++L  + +   
Sbjct: 2280 HPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSL 2339

Query: 8218 --DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL---------------S 8260
              D+H     EL  +  A L  L    R     L+ Q S N  L               +
Sbjct: 2340 QWDDHREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVMAFDN 2396

Query: 8261 LAQPLRSERSGRDT---PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8317
            + Q L  E    DT     + + +   W +      D ++A+     +     +D ++F 
Sbjct: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFL 2456

Query: 8318 ---------LRGAVGLSGDHSALESQI--RQLGKALDDSRFQIQQTENIIRSKTPTGPEL 8366
                     +   V  S   +AL+  I  R+L + + D + +I    +I +S       +
Sbjct: 2457 KWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKS-------I 2509

Query: 8367 DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQA 8426
            D + +  +K LG      +    L+H+L +  +                    RW  L+A
Sbjct: 2510 DGNRQKMVKALGNS----EEATMLQHRLDDMNQ--------------------RWNDLKA 2545

Query: 8427 QALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK 8486
            ++ S    ++ + +KW +    L  +  WL   +EEL+  +++ +  D+  ++LQ    K
Sbjct: 2546 KSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK--KQMPIGGDVPALQLQYDHCK 2603

Query: 8487 ELQK-----------AVDHRKAIILSINLCSPEFTQAD-------------SKESRDLQD 8522
             L++           AVD  +  +    + +PE  + +              K ++ ++ 
Sbjct: 2604 ALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRK 2663

Query: 8523 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN 8582
            + S++  +W+ + ++   W+  +  AL + +        L   ++  +  +N   P+  +
Sbjct: 2664 QSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPV-GD 2722

Query: 8583 LDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL 8642
            L  + LQDH +++M  + E+     +V ++ D+S Q L   +    L+   ++  +  R 
Sbjct: 2723 LLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-LSPLDLHPSLKMSRQLDDLNMRW 2781

Query: 8643 KLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 8673
            KLL   V   +K+L++   D   S Q   S S
Sbjct: 2782 KLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTS 2813



 Score = 67.4 bits (163), Expect = 6e-10
 Identities = 198/1080 (18%), Positives = 416/1080 (38%), Gaps = 159/1080 (14%)

Query: 7750 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI 7809
            + E++ LL  +WE L  +   R+ ++ + L E  +  ++ ++L  WLT  E ++ +    
Sbjct: 390  IQEQMTLLNARWEALRVESMDRQSRLHDVLME--LQKKQLQQLSAWLTLTEERIQKMETC 447

Query: 7810 LIEEMIEKLKKDYQEEIAI-----AQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVN 7863
             +++ ++ L+K  +E  ++     A++ K+  L  M   + + S ES  + +E +L K+ 
Sbjct: 448  PLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLG 507

Query: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 7923
            +RW  +      R  +L+E  +  Q+L +    L+ WL   E  L K    +  + +E+ 
Sbjct: 508  ERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELS 567

Query: 7924 RKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS-IQQATRNLDRRWRN 7982
              +     L+ D+E         L+    +  D      +++    I   +  L +RW +
Sbjct: 568  VSVRRLAILKEDMEMKR----QTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDS 623

Query: 7983 ICAMSMERRLKIEETW------RLWQKFLDDYSRFEDWL---KSSERTAAFPSSSGVIYT 8033
            +     +   ++ +        ++ QK L +  R  +     KS +     P        
Sbjct: 624  LVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIH 683

Query: 8034 VAKEELKKFEAFQRQVHECL----TQLELIN-KQYRRLARENRTDSACSLKQMVHEGNQR 8088
            V  E  KKF+A   ++   +    T ++    K+Y ++  ++ ++    LK +  E  +R
Sbjct: 684  VDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKM--QDTSEMKKKLKALEKEQRER 741

Query: 8089 W---DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQ 8143
                D L +    ++ ++       EE +   + +      +   L ++E   +   D+ 
Sbjct: 742  IPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDIN 801

Query: 8144 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 8203
            A  KQL           +++E++I   E+ ++ +   +++   + L  L+  CQ     +
Sbjct: 802  AYFKQL-----------DELEKVIKTKEEWVKHTSISESS--RQSLPSLKDSCQRELTNL 848

Query: 8204 ERYHKK----------LIRLPLPDD----------------EHDLSDRELELEDSAALSD 8237
               H K          L+  P   D                +  + DR+  LE+      
Sbjct: 849  LGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQP 908

Query: 8238 LHWHDRSA----DSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD--YDL 8291
             H +  +     D L   +  + +SL++   L           ++D I LE      + L
Sbjct: 909  GHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI-LENQKPALHKL 967

Query: 8292 SRDLESAMSRALPSED----EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRF 8347
            + + ++      P  +    +E  D +  + +  V +S D   LE +I    +A +    
Sbjct: 968  AEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLE-EIALTLRAFEADST 1026

Query: 8348 QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 8407
             I++  + ++              G  + L +CS+ ++ ++ +E  LK  +E      NL
Sbjct: 1027 VIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE---TNL 1083

Query: 8408 HS---------TETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGD 8458
             S          +T+      + E L  +  +++ R+ ++ +K      DL  +  W+  
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143

Query: 8459 TEEE-LEQLQRLELSTDIQTIELQIKKLKE--LQKAV------DHRKAIILSINLCSPEF 8509
             EEE LE+    +   ++++   ++K+ KE  LQK V      D+ K +   +     E 
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203

Query: 8510 TQADSKESRDLQDRLSQMNGRWDRVCSLLEE-----------------WRGLLQDALMQC 8552
            T   +    + Q   +++ G+    C  LEE                 W   L++ +   
Sbjct: 1204 TSELNVVLENYQLLCNRIRGK----CHTLEEVWSCWIELLHYLDLETTWLNTLEERMKST 1259

Query: 8553 QGFHEMSHGLLLMLENIDR-------RKNEIVPIDSNL-DAEILQDHHKQLMQIKHELLE 8604
            +   E +  +   LE+++         + +I  +   L D  IL D    ++  K E   
Sbjct: 1260 EVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDD----IISEKLEAFN 1315

Query: 8605 SQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
            S+    S    S Q+ +  +     E  + + V+   L  L K+++ ++ +      V  
Sbjct: 1316 SRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQ 1375

Query: 8665 SQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS 8724
              Q + +  SA EL        T      N +  P            ++SP SR+ +GGS
Sbjct: 1376 EAQKIQAEISAHEL--------TLEELRRNMRSQP------------LTSPESRTARGGS 1415



 Score = 46.6 bits (109), Expect = 0.001
 Identities = 59/289 (20%), Positives = 133/289 (46%), Gaps = 32/289 (11%)

Query: 8383 SIDSVKRLE-----HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQ 8437
            +ID+++ +E     +K + EEE+    +N+ ST  +     +  E  +A+  S    +  
Sbjct: 259  TIDAIREVETLPRKYKKECEEEA----INIQSTAPE-----EEHESPRAETPSTVTEVDM 309

Query: 8438 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKA 8497
            +L  +Q     L  +  WL   E+  ++    ++S D++ ++ Q    +     +   ++
Sbjct: 310  DLDSYQ---IALEEVLTWLLSAEDTFQEQD--DISDDVEEVKDQFATHEAFMMELTAHQS 364

Query: 8498 IILSI----NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8553
             + S+    N    + T +D +E  ++Q++++ +N RW+ +     + +  L D LM+ Q
Sbjct: 365  SVGSVLQAGNQLITQGTLSDEEEF-EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQ 423

Query: 8554 --GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA-EILQDHHKQLMQIKHELLESQLRVA 8610
                 ++S  L L  E I  +K E  P+D ++ + + L + HK L   + +L   Q++V 
Sbjct: 424  KKQLQQLSAWLTLTEERI--QKMETCPLDDDVKSLQKLLEEHKSL---QSDLEAEQVKVN 478

Query: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 8659
            SL  M   +  N+  +     ++++  +G R   + +        L+++
Sbjct: 479  SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527


>gi|145580592 nesprin-3 [Homo sapiens]
          Length = 975

 Score =  285 bits (729), Expect = 1e-75
 Identities = 193/751 (25%), Positives = 370/751 (49%), Gaps = 15/751 (1%)

Query: 2624 QEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM 2683
            Q  +  + +++    W+KA+QD+L   ++T G +  LE RL + + I  ++ EG V++++
Sbjct: 4    QPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63

Query: 2684 AIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2743
             +   E  L     + +  I  +L+ +K  W + ++   H  S +E V   W++Y+  ++
Sbjct: 64   VLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARD 123

Query: 2744 QLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK 2803
            +  +W + +   +E  ++ Q GLKEK   L H Q +L   ++    L RL+ ++  L+ +
Sbjct: 124  EFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183

Query: 2804 TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
              D S  + AQ+ +K +++ +   A++++  +E++ ++H  Y   V EF  WL +  E++
Sbjct: 184  IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243

Query: 2864 HRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM 2923
            +     +     TQ +LS ++++      G   L  +E  +  V +NT+  G E +  E+
Sbjct: 244  NGCLGRNCKLPITQ-RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302

Query: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ- 2982
            + +R   ++      + +  L  L+      EQ    Q+ QLE  L +F  +L+  AQ+ 
Sbjct: 303  EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQ----QIKQLEAELSEFRMVLQRLAQEG 358

Query: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
            L       T++E+V  W +      AL   EPR + L++QL EL  F  +L   S  V  
Sbjct: 359  LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418

Query: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
             I+EY  L +++++        L Q F++  +D Q W   A+        +P ++  + T
Sbjct: 419  TIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLHT 477

Query: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
             L +I+  L ES   +  L M+  K +LL  +  +E+A  +  +V  +  D    H++L 
Sbjct: 478  FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537

Query: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE 3222
            Q++S L++L  Q KDF  + EP+Q  L   +  V        DLP K+ +  +LQ + EE
Sbjct: 538  QRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEE 597

Query: 3223 IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEH 3282
                  Q+   +   Q+       + + +H++ QLSS + AL    ++ V R  + V EH
Sbjct: 598  GLDLGAQMEAARPLVQE-------NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEH 650

Query: 3283 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3342
              FS  + EL+ W+      L+++    +     +S+  + E L++   EKE Q+ ++  
Sbjct: 651  CTFSHQLLELRQWIVVTTQKLEAH-RGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASL 3373
            +G  V++ +SPEG   +Q++L+ + + W +L
Sbjct: 710  QGWLVMEKSSPEGAAVVQEELRELAESWRAL 740



 Score =  118 bits (296), Expect = 2e-25
 Identities = 137/687 (19%), Positives = 285/687 (41%), Gaps = 42/687 (6%)

Query: 3283 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3342
            + F   +++ Q WM      L    +    ++ L++R  + E +  ++ E  +++ +++ 
Sbjct: 7    DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66

Query: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
              E++L     +  P I  +L+ +K  W   ++    C S++E     W+ Y     +F 
Sbjct: 67   MAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFY 126

Query: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3462
             W   M   L         L++K   L  A++L   V + + LL+ +  + A +      
Sbjct: 127  RWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD 186

Query: 3463 QLELQDLQER----YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3518
                +D Q+R    Y A++ +A++ V   E++ R H+EYQ  +  F++WL    EK++  
Sbjct: 187  PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVN-- 244

Query: 3519 SVLEGDAHTHET-TLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAED-------- 3569
              L  +     T  L  LQ++      G+  L ++      VI +  P   +        
Sbjct: 245  GCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEE 304

Query: 3570 --RALESLRQDWQAYQHRLS---ETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPR 3624
              + LE LR  W+  + RL     +R  +   + +L     +F+ V +  + A+E + P 
Sbjct: 305  MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQ--RLAQEGLQPA 362

Query: 3625 TRRQSNRATKEIQLHQMKKWHEEVTAYRDE---VEEVGARAQEILDESHVNSRMGCQATQ 3681
             +      T++  +   +++     A   E   V+ + A+ +E++   H    +      
Sbjct: 363  AK----AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418

Query: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
                YQ+L ++          E+   +  +  L     W     +  +  A+     D  
Sbjct: 419  TIQEYQSLKVKSARLRNAAAVEL--WQHFQRPLQDLQLWKALAQRLLEVTAS---LPDLP 473

Query: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
             +   L  +E  L +  +   LL   + K +  +    +  A  L +++   M     L 
Sbjct: 474  SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLH 533

Query: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
            +++ +    L+  L   K+F    + L + + + Q  +   +  + +L  K+AQLS+ + 
Sbjct: 534  NSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593

Query: 3862 LQQTVLSHEPSVKSVREKGEALLELVQD-VTLKDKIDQLQSDYQDLCSIGKEHVFSLEAK 3920
            LQ+  L        +  + EA   LVQ+    + K+DQL SD+Q L    ++ V      
Sbjct: 594  LQEEGL-------DLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQS 646

Query: 3921 VKDHEDYNSELQEVEKWLLQMSGRLVA 3947
            V++H  ++ +L E+ +W++  + +L A
Sbjct: 647  VQEHCTFSHQLLELRQWIVVTTQKLEA 673



 Score = 90.9 bits (224), Expect = 5e-17
 Identities = 184/968 (19%), Positives = 385/968 (39%), Gaps = 104/968 (10%)

Query: 3496 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3555
            ++ R ++  + W+   Q++L      +G     E  L + +++     EG+  ++ VL  
Sbjct: 8    DFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRM 67

Query: 3556 REDVI---PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVV---NKLRLMEQKFQQ 3609
             E ++   P          L+ ++  W+     ++   ++   V    ++  L   +F +
Sbjct: 68   AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
               W +     + P    Q     K+ QL      H +V  +   V+        +L+E+
Sbjct: 128  ---WFQKMMVTLEPHIELQLGLKEKQWQLS-----HAQVLLHN--VDNQAVLLDRLLEEA 177

Query: 3670 -HVNSRMGCQAT------QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYG 3722
              + +R+G  +       ++ + Y A+  +  +++  LE+  +  EE ++ +  +  W  
Sbjct: 178  ASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK 237

Query: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
            +  +       +  K+      ++L TL+ + KD  +G   L++  E+    ++      
Sbjct: 238  AVVEKVNGCLGRNCKLPIT---QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLG 294

Query: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
            AE++  E+ +  + L++L +   +E   L   L     +  + K L   ++E++ +L   
Sbjct: 295  AEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRL 354

Query: 3843 EEPKMELYEKK-------AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT-LKD 3894
             +  ++   K        A   +Y + +  + S EP V  ++ + + L+    ++  L D
Sbjct: 355  AQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSD 414

Query: 3895 KIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW------LLQMSGRLVAP 3948
             +     +YQ L    K       A V+  + +   LQ+++ W      LL+++  L  P
Sbjct: 415  SVIATIQEYQSLKV--KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASL--P 470

Query: 3949 DLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHA 4008
            DL    SL T   Q+   +A + E +  ++ L  LQ+K D LIG         L + V  
Sbjct: 471  DL---PSLHTFLPQI---EAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAG 524

Query: 4009 HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQ----CQAWLSA---VQPDLEP 4061
             ++     ++++     ++ QSL  + +   +  + LQ+     Q  + A   +Q DL P
Sbjct: 525  SMRDRDLLHNSLLQRKSKL-QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDL-P 582

Query: 4062 SPQPPLSRAEAIKQV-KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQ 4120
              Q  LSR + +++      A  E AR     L          +   + D Q  ++++E 
Sbjct: 583  GKQAQLSRLQGLQEEGLDLGAQMEAARP----LVQENPNHQHKMDQLSSDFQALQRSLED 638

Query: 4121 KLVQAQNLTQGWEEIKHLKSEL--WIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
             + + +   Q      H   EL  WI +       Q ++    E     A++  ++ +  
Sbjct: 639  LVDRCRQSVQEHCTFSHQLLELRQWIVV-----TTQKLEAHRGEAGPGDAESQEAEFERL 693

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
            V +   K+A + +++E    L  ++ SPE   +  + ++  +L      L L  E  L  
Sbjct: 694  VAEFPEKEAQL-SLVEAQGWLVMEKSSPEGAAV--VQEELRELAESWRALRLLEESLLSL 750

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVH-LEALKKLALALQERKYAIEDLKD 4297
             R++H  +  +EV   K     +N+ +S      +  +   ++ A  LQE + + ED   
Sbjct: 751  IRNWH--LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQ 808

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
              +   + L +++ +LV                   R I +  +  E+L   +S+ QEL 
Sbjct: 809  LLRNFGQWLQVENSKLV-------------------RIIAMRTSTAEDLRTRKSKLQELE 849

Query: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
                E Q      L+  P    +  L         +L  + ML KS +KD+  ++     
Sbjct: 850  ARVPEGQHLFENLLRLGPARGTSDEL--------EDLRYQWMLYKSKLKDSGHLLTQSSP 901

Query: 4418 NERQVIQK 4425
             E    QK
Sbjct: 902  GEPTGFQK 909



 Score = 72.4 bits (176), Expect = 2e-11
 Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)

Query: 8427 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8481
            QAL + L     R +Q++Q+   F+  L  +  W+  T ++LE  +      D ++ E +
Sbjct: 630  QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689

Query: 8482 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
             ++L      KE Q ++   +  ++ +   SPE      +E R+L +    +    + + 
Sbjct: 690  FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748

Query: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
            SL+  W           Q     S   ++   NI +    I P+D       +  H ++ 
Sbjct: 749  SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793

Query: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
              ++ E         S +D S QLL N      +E  + V +I  R        +R  K 
Sbjct: 794  NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845

Query: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
             E    V   Q         + L   G    TS      R +    K  L   G  ++  
Sbjct: 846  QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898

Query: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 8774
                +  G  +   +    R G G LFR     ALPLQLLLLL + L  L+P+ EED SC
Sbjct: 899  ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953

Query: 8775 ALSNNFARSFHPMLRYTNGPPP 8796
             L+NNFARSF  MLRY NGPPP
Sbjct: 954  TLANNFARSFTLMLRY-NGPPP 974



 Score = 68.9 bits (167), Expect = 2e-10
 Identities = 115/641 (17%), Positives = 250/641 (39%), Gaps = 55/641 (8%)

Query: 2119 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL---------KKIHSSDFSLVKT 2169
            ++ +W  S  +   + ++ +   LD    +   L + +         +K   +++  VK 
Sbjct: 147  KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKA 206

Query: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW-SNNCVPQMAENISNLD 2228
              +  VD    V+ + EE    +     +W  + +  +++ G    NC   + + +S L 
Sbjct: 207  KAQKRVDLLEQVAREHEEYQAGVD-EFQLW--LKAVVEKVNGCLGRNCKLPITQRLSTLQ 263

Query: 2229 NHL----RAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQFIEADLM 2282
            +      R EE L+  E +          L ++    +L+E+ K LE    L   E + +
Sbjct: 264  DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERL 323

Query: 2283 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEAL--- 2339
            + L  ++   E     +K   A+ ++    +  +       +E L   A+  T + L   
Sbjct: 324  RGLLRSRGAWEQQ---IKQLEAELSEFRMVLQRLA------QEGLQPAAKAGTEDELVAH 374

Query: 2340 -KKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSK 2398
             ++    +  L S++  +   Q  L  L    H+  L+ L  ++   I++++++    ++
Sbjct: 375  WRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLKVKSAR 432

Query: 2399 TQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG---DSKVLEAKLHDLQNILDS 2455
             + +    L +HF   +Q+ Q W    KA A+   + T    D   L   L  ++  L  
Sbjct: 433  LRNAAAVELWQHFQRPLQDLQLW----KALAQRLLEVTASLPDLPSLHTFLPQIEAALME 488

Query: 2456 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2515
             S  +  L  +  +   L     ++  +++ EQ+  +  +        L+ K  LQ   +
Sbjct: 489  SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548

Query: 2516 ELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLD 2575
            +   F      L   + +++ R   E     ++ +P K+ ++ +++    E L     ++
Sbjct: 549  QHKDFGAAFEPLQRKLLDLQVRVQAEK--GLQRDLPGKQAQLSRLQGLQEEGLDLGAQME 606

Query: 2576 KLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQS 2635
                  Q      H          QL +  Q L R  ++ +  C+ ++QEH      L  
Sbjct: 607  AARPLVQENPNHQH-------KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659

Query: 2636 MWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSS 2695
            +  W+     +L       G  D  E + ++ + ++    E E +L++   +G   +  S
Sbjct: 660  LRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKS 718

Query: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            + EG  V+Q +L  L E W  +       + +L S+I  W+
Sbjct: 719  SPEGAAVVQEELRELAESWRALRL----LEESLLSLIRNWH 755



 Score = 65.1 bits (157), Expect = 3e-09
 Identities = 163/863 (18%), Positives = 327/863 (37%), Gaps = 97/863 (11%)

Query: 6879 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIK 6938
            + L  I +QW + +T +     ++  + +       A  E   W   M   +   E +I+
Sbjct: 85   ARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTL---EPHIE 141

Query: 6939 NSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGA 6998
              +G K     L   +    +++ + + +D + +    + +     +  D +   +    
Sbjct: 142  LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-----RIGDPSVDEDAQKR 196

Query: 6999 MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQ 7058
            M   +  ++    +++ LLE +     EY+  V   + W +   +++        +  + 
Sbjct: 197  MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPIT 256

Query: 7059 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7118
              L   QD+       E+ +E +E+    +I+N     +  +   L E+ +    L  + 
Sbjct: 257  QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALW 316

Query: 7119 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF-------RLLTGSLEAVQVQVD 7171
             + +  L+ +L    + +    ++ + L E R  L R            G+ + +     
Sbjct: 317  EEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWR 376

Query: 7172 NLQNLQDDLEKQERSLQKFGSITNQLLKECH--PPVTETLTNTLKE--------VNMRWN 7221
                 +  L  +E  + +  +   +L+   H   P+++++  T++E          +R N
Sbjct: 377  RYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLR-N 435

Query: 7222 NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL--LKAATNKDIADDEV 7279
                E+ +  Q     LQLW+       +  +++         L  ++AA  +     E+
Sbjct: 436  AAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKEL 495

Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
             T +Q   DLL G+        F  E    L +QV    A +++   L        L  +
Sbjct: 496  LTMLQLKKDLLIGI--------FGQERATALLEQV----AGSMRDRDL--------LHNS 535

Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERM 7393
            L ++++ LQ+ +  ++ F  + E L+  +      V+AE+ LQ   P   + LS +Q   
Sbjct: 536  LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQ 595

Query: 7394 EELKGQMLKFSSMAPDLDRLNELGYRLPL---NDKEIKRMQNLNRHWSLISSQTTERFSK 7450
            EE              LD   ++    PL   N     +M  L+  +  +     +   +
Sbjct: 596  EE-------------GLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR 642

Query: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAH-ELFQAEMFSRQQ 7509
             +  + +H TF  +     +++V T QKL            E Q A  E   AE   ++ 
Sbjct: 643  CRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEA 702

Query: 7510 ILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYR 7569
             L  +   G  ++E+   +       +L  L+  W+  +R  ++    + S IR W   R
Sbjct: 703  QLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR-ALRLLEES---LLSLIRNWHLQR 758

Query: 7570 EMAEKLRKWLVEVSYLPMSGL---GSVPIPLQQAR-TLFDEVQFKEKVF---LRQQGSYI 7622
               +  +K +V  + +P SG       PIP  + R  L  E +   + F   LR  G + 
Sbjct: 759  MEVDSGKK-MVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQW- 816

Query: 7623 LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKC--EK 7680
            L VE  K + +        A++   AE     KS    LE +  +   L ++  +    +
Sbjct: 817  LQVENSKLVRI-------IAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLRLGPAR 869

Query: 7681 GIADSLEKLR----TFKKKLSQS 7699
            G +D LE LR     +K KL  S
Sbjct: 870  GTSDELEDLRYQWMLYKSKLKDS 892



 Score = 60.5 bits (145), Expect = 7e-08
 Identities = 152/842 (18%), Positives = 315/842 (37%), Gaps = 104/842 (12%)

Query: 2815 EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSS 2874
            +++K Q+ + +T       ++E +      YL A  EF  W       L    ++     
Sbjct: 88   KDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK 147

Query: 2875 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2934
              Q +LS  + L+ + +  A  L R+   A  +         +      + ++A++    
Sbjct: 148  EKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD--EDAQKRMKAEY---- 201

Query: 2935 DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEE 2994
            D+V        +L+ Q+A   +E+   V       ++F   LK   +++    G+N    
Sbjct: 202  DAVKAKAQKRVDLLEQVAREHEEYQAGV-------DEFQLWLKAVVEKVNGCLGRNCKLP 254

Query: 2995 IVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3054
            I +     Q+I     + E   E L+ Q   + R +  L   + K++G ++E   + L+ 
Sbjct: 255  ITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLG--AEKITGELEEMRKV-LEK 311

Query: 3055 SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS-LQKIQEFLSE 3113
             +    +E+   +R R   R    W    K   A+  +    +  ++   LQ   +  +E
Sbjct: 312  LRALWEEEE---ERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTE 368

Query: 3114 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3173
             E   H      ++  L S     ++ +    ++     + K    ++       ++LK+
Sbjct: 369  DELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKV 428

Query: 3174 QMKDFEVSA---------EPIQD---WLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLE 3221
            +      +A          P+QD   W +  ++++  +++ L DLP+      ++++ L 
Sbjct: 429  KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALM 487

Query: 3222 EIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIV 3279
            E    +  L  L+ K   L    GQ  + +   +V+        L N   ++ S+L  ++
Sbjct: 488  ESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLL 547

Query: 3280 AEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKM 3339
            A+H  F    + LQ  + D    + +      D     ++  +L+ L    QE+ + +  
Sbjct: 548  AQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGL----QEEGLDLGA 603

Query: 3340 IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3399
             +     ++Q  +P     + Q     + +  SL     RC+  ++    +  ++   + 
Sbjct: 604  QMEAARPLVQE-NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTFSHQLL 658

Query: 3400 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEH 3459
            +   W+      L E+ R  A   D  +   + + L  E     + L  +E +G  + E 
Sbjct: 659  ELRQWIVVTTQKL-EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEK 717

Query: 3460 Y------VTQLELQDLQERYRAIQ--ERAKEAVTKSEKLVRL------------------ 3493
                   V Q EL++L E +RA++  E +  ++ ++  L R+                  
Sbjct: 718  SSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSG 777

Query: 3494 -------------------------HQEYQRDLKAFEVWLGQEQEKLDQYSVLE-GDAHT 3527
                                     H+++ + L+ F  WL  E  KL +   +    A  
Sbjct: 778  FLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED 837

Query: 3528 HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLS 3587
              T    LQEL+    EGQ       H  E+++  G  +     LE LR  W  Y+ +L 
Sbjct: 838  LRTRKSKLQELEARVPEGQ-------HLFENLLRLGPARGTSDELEDLRYQWMLYKSKLK 890

Query: 3588 ET 3589
            ++
Sbjct: 891  DS 892



 Score = 60.5 bits (145), Expect = 7e-08
 Identities = 159/775 (20%), Positives = 294/775 (37%), Gaps = 146/775 (18%)

Query: 6995 QLGAMNKSWQ-----ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 7049
            QLG   K WQ     +L   V  +  LL+ LLE  +   N                    
Sbjct: 143  QLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-------------------- 182

Query: 7050 RIGDQASVQNALKDCQDLEDLIKAK-EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELG 7108
            RIGD +  ++A K  +   D +KAK +K V+ +EQ                     RE  
Sbjct: 183  RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQ-------------------VAREHE 223

Query: 7109 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 7168
            +  A +D    + ++ LK+V++          K+N  L                   +  
Sbjct: 224  EYQAGVD----EFQLWLKAVVE----------KVNGCLGR------------NCKLPITQ 257

Query: 7169 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNM---RWNNLLE 7225
            ++  LQ++  D  + E SL+     +  +++   P   E +T  L+E+     +   L E
Sbjct: 258  RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317

Query: 7226 EIAEQLQSSKALLQLW-QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
            E  E+L+        W Q+ K    + +      +    E L+ A      D+ VA W +
Sbjct: 318  EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377

Query: 7285 DCN------------DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 7332
                           D L+    +K+ + F H L     + +  S  + IQ  Q SL   
Sbjct: 378  YSATRAALASEEPRVDRLQA--QLKELIVFPHNL-----KPLSDSVIATIQEYQ-SLKVK 429

Query: 7333 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQER 7392
               L  A         A V  ++ F + L+ L+ W   A+ +L+    +   DL ++   
Sbjct: 430  SARLRNA---------AAVELWQHFQRPLQDLQLWKALAQRLLEVT--ASLPDLPSLHTF 478

Query: 7393 MEELKGQMLKFSSMAPDLDRLN-ELGYRLPLNDKE-----IKRMQNLNRHWSLISSQTTE 7446
            + +++  +++ S +   L  L  +    + +  +E     ++++    R   L+ +   +
Sbjct: 479  LPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQ 538

Query: 7447 RFSKLQSFLLQHQTF------LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500
            R SKLQS L QH+ F      L++    ++  VQ E+ L  ++ G    L   Q   E  
Sbjct: 539  RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQE-- 596

Query: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
                         + +  Q    +  V +      K+  LS+ +Q + R  +        
Sbjct: 597  -----------EGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQ 645

Query: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV-PIPLQQARTLFDEV--QFKEKVFLRQ 7617
             +++   +     +LR+W+V  +    +  G   P   +     F+ +  +F EK     
Sbjct: 646  SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK----- 700

Query: 7618 QGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWE 7676
              + +  VEA   L++   S   AA +Q EL E+ E W+  ++RL E+   L  L+++W 
Sbjct: 701  -EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR--ALRLLEE--SLLSLIRNWH 755

Query: 7677 KCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7731
                 +    + + T     S  L +  + +   + R   L+   GS  +D +QL
Sbjct: 756  LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS-HEDFSQL 809



 Score = 58.5 bits (140), Expect = 3e-07
 Identities = 142/799 (17%), Positives = 309/799 (38%), Gaps = 75/799 (9%)

Query: 2411 FSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEG 2470
            F  S+++ Q W    +   + + +  G    LEA+L + + I     +G+ ++D V +  
Sbjct: 9    FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68

Query: 2471 QTLYAHL---SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
            + L A      K  + +  + I    EE   ++  C    + +    SE     D+  + 
Sbjct: 69   EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR- 127

Query: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
              W  +M      E   E +  + EK+ ++   ++ L  +      LD+L +    L   
Sbjct: 128  --WFQKM--MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183

Query: 2588 GHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRL 2647
                  +     ++   +  +    ++++   +   +EHE  +  +     W+KA+ +++
Sbjct: 184  IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243

Query: 2648 ACAESTLG--SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQT 2705
                  LG   K  + +RLS +QDI      GE  L     +    +R+++  G   I  
Sbjct: 244  ---NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300

Query: 2706 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2765
            +LE +++V              LE + + W +  ER   L +   + +Q+I+   Q +  
Sbjct: 301  ELEEMRKV--------------LEKLRALWEEEEERLRGLLRSRGAWEQQIK---QLEAE 343

Query: 2766 LKEKFVLLDHL-QSILSEA-----EDHTRALHRLIAKSRELYEKTEDESFKDTAQ-EELK 2818
            L E  ++L  L Q  L  A     ED   A  R  + +R      E    +  AQ +EL 
Sbjct: 344  LSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI 403

Query: 2819 TQFNDIMTVAKEKMRKVEEI----VKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG--- 2871
               +++  ++   +  ++E     VK   +   A  E         ++L  W  ++    
Sbjct: 404  VFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLL 463

Query: 2872 DSSATQKKLSKIKELIDSREIGASRLSRVESLAP--EVKQNTTAS--GCELMHTEMQALR 2927
            + +A+   L  +   +   E      SR++ L    ++K++      G E     ++ + 
Sbjct: 464  EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVA 523

Query: 2928 ADWKQWE---DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT 2984
               +  +   +S+ Q +S L++L++Q     ++F      L++ L      ++       
Sbjct: 524  GSMRDRDLLHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQR 579

Query: 2985 LLEGKNTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGL 3043
             L GK      +     +G ++   ++ A P  ++  +  +++ + S D       +  L
Sbjct: 580  DLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDL 639

Query: 3044 IKEYNCLCLQA-SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAK--CFDIPQNISEV 3100
            +      C Q+  + C    Q+L+ R         QW+V   +TT K           + 
Sbjct: 640  VDR----CRQSVQEHCTFSHQLLELR---------QWIV---VTTQKLEAHRGEAGPGDA 683

Query: 3101 STSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3160
             +   + +  ++E    + +L+++ ++G L+    + E A  +Q ++    E W+     
Sbjct: 684  ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLL 743

Query: 3161 LHQKESALENLKIQMKDFE 3179
                 S + N  +Q  + +
Sbjct: 744  EESLLSLIRNWHLQRMEVD 762



 Score = 58.2 bits (139), Expect = 4e-07
 Identities = 143/777 (18%), Positives = 288/777 (37%), Gaps = 92/777 (11%)

Query: 2848 AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2907
            +V +   W+ + +++L    +  G  +A + +L + +++      G  R+  V  +A  +
Sbjct: 12   SVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEAL 71

Query: 2908 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEFSGQ 2961
                       +   ++ ++A   QWE++V     C   +       S+  L+  EF   
Sbjct: 72   LACCPGDQKPGILARLKDIKA---QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128

Query: 2962 VAQLEQALE-----QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3016
              ++   LE     Q     K W      +   N D + V        +LD L       
Sbjct: 129  FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAV--------LLDRL------L 174

Query: 3017 EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRKAFR 3074
            E+  S  N +     D S        +  EY+ +  +A K     EQ+ ++   ++    
Sbjct: 175  EEAASLFNRI----GDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230

Query: 3075 DFQQWLV------------NAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3122
            +FQ WL             N K+   +     Q+I++     ++  E L E   G  +  
Sbjct: 231  EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290

Query: 3123 MMLSKGELLSTLLTKEKAKGIQAKVTAA-KEDWKNFHSNLHQK---ESALENLKIQMKDF 3178
              L   ++   L   E+ + +  K+ A  +E+ +     L  +   E  ++ L+ ++ +F
Sbjct: 291  SPLGAEKITGEL---EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEF 347

Query: 3179 EVSAEPI-QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA 3237
             +  + + Q+ L    K   E      +L A  R     ++ L      EP+++RL+ + 
Sbjct: 348  RMVLQRLAQEGLQPAAKAGTED-----ELVAHWRRYSATRAALAS---EEPRVDRLQAQL 399

Query: 3238 QQLWEGQAASKSFRHRVSQLSSQYLALSN---LTKEKVSRLDRIVAEH--NQFSLGIKEL 3292
            ++L         F H +  LS   +A        K K +RL    A      F   +++L
Sbjct: 400  KELIV-------FPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDL 452

Query: 3293 QDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3352
            Q W   A  +L+       D   L +   ++EA L      +  + M+  + + ++    
Sbjct: 453  QLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511

Query: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
             E    + +Q+         L ++ ++ KS+L+  L++   +          +  ++  +
Sbjct: 512  QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571

Query: 3413 NESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQER 3472
               +    +L  K   L + + L EE L   + +E           H   Q ++  L   
Sbjct: 572  QAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628

Query: 3473 YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY--SVLEGDAHTHET 3530
            ++A+Q   ++ V +  + V+ H  +   L     W+    +KL+ +      GDA + E 
Sbjct: 629  FQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEA 688

Query: 3531 TLRDL------QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQA 3581
                L      +E Q+   E Q  L       E   P G    ++  L  L + W+A
Sbjct: 689  EFERLVAEFPEKEAQLSLVEAQGWL-----VMEKSSPEGAAVVQEE-LRELAESWRA 739



 Score = 52.0 bits (123), Expect = 3e-05
 Identities = 143/725 (19%), Positives = 270/725 (37%), Gaps = 93/725 (12%)

Query: 5514 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5573
            +A+ R+  L Q A   EEY   ++    W++      +G +  N    + ++    Q + 
Sbjct: 207  KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIA 266

Query: 5574 EESKEIDSELEAMTEKLQYL---TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5630
            ++    +  LE + E+   +   TS    EK++ ++ E+ +  E+LR + +   + L+  
Sbjct: 267  KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGL 326

Query: 5631 AKDMKKFEAELKKLQAALEQAQATL-------TSPEVGRLSLKEQLSHRQHLLSEMESLK 5683
             +    +E ++K+L+A L + +  L         P     +  E ++H +   +   +L 
Sbjct: 327  LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386

Query: 5684 PKVQAVQLCQSALR----IPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ 5739
             +   V   Q+ L+     P ++    PL  + +   +E   L+   ++   +  AA V+
Sbjct: 387  SEEPRVDRLQAQLKELIVFPHNL---KPLSDSVIATIQEYQSLK---VKSARLRNAAAVE 440

Query: 5740 YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN 5799
              Q+ Q      QL +   + + +   +  ++  L   + + E    +    +E +  L 
Sbjct: 441  LWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500

Query: 5800 SKCKML--TMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------ 5851
             K  +L      + AT LL   +V G     + L   LL   S   S++           
Sbjct: 501  LKKDLLIGIFGQERATALL--EQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558

Query: 5852 -RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910
                 LL        E+G   ++    A                 ++  Q L  E L   
Sbjct: 559  PLQRKLLDLQVRVQAEKGLQRDLPGKQA----------------QLSRLQGLQEEGLDL- 601

Query: 5911 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 5970
             A++  +    QE   P  +        D Q    +L++++   ++++ E      +  +
Sbjct: 602  GAQMEAARPLVQE--NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659

Query: 5971 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEE--- 6027
              Q I    + +E    E+  PG   ESQ AE + L+ E         E Q SL E    
Sbjct: 660  LRQWIVVTTQKLEAHRGEA-GPG-DAESQEAEFERLVAEF-----PEKEAQLSLVEAQGW 712

Query: 6028 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQR 6087
            LV E  ++ P     +Q  L  LAE    +R        LLEE L   +     +     
Sbjct: 713  LVME--KSSPEGAAVVQEELRELAESWRALR--------LLEESLLSLIRNWHLQ----- 757

Query: 6088 YRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSE----- 6142
             R E D     + +        L  P +P+    +     N+L E E      S+     
Sbjct: 758  -RMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR---ANLLQEEEGSHEDFSQLLRNF 813

Query: 6143 ---LSVHNENL--LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM---QGTA 6194
               L V N  L  ++  +  T ++      KL+ L+  + E Q  L +  L +   +GT+
Sbjct: 814  GQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQH-LFENLLRLGPARGTS 872

Query: 6195 QEKEE 6199
             E E+
Sbjct: 873  DELED 877



 Score = 51.2 bits (121), Expect = 4e-05
 Identities = 113/613 (18%), Positives = 226/613 (36%), Gaps = 39/613 (6%)

Query: 7891 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 7948
            D+++   + W+  ++ +L    V D+       ++ +L E +++ +   +    V  VL 
Sbjct: 10   DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66

Query: 7949 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 8008
            + E LL    AC    +   I    +++  +W            +IE  W  W ++L   
Sbjct: 67   MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122

Query: 8009 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 8068
              F  W +    T   P     +    KE+  +    Q  +H    Q  L+++     A 
Sbjct: 123  DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179

Query: 8069 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 8127
              NR       +         +D ++ +    +  L+    + EE++   D   +WL  +
Sbjct: 180  LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239

Query: 8128 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 8186
              ++   +    +  +  ++  L+   ++       +E +  Q   +I  + PL A  I 
Sbjct: 240  VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299

Query: 8187 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8246
             EL+E+R+  +++    E   ++L  L       +   ++LE E S     L    R A 
Sbjct: 300  GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVL---QRLAQ 356

Query: 8247 SLLSPQPSSNLSLSLAQPLRSERSGRDTPAS----VDSIPLEWDHDYDLSRDLESAMSRA 8302
              L P   +     L    R   + R   AS    VD +  +         +L+      
Sbjct: 357  EGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSV 416

Query: 8303 LPS-EDEEGQDDKDFYLRGAVGLS-GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKT 8360
            + + ++ +    K   LR A  +    H     Q  QL KAL     +       + +  
Sbjct: 417  IATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLE-------VTASL 469

Query: 8361 PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET---QTAGV 8417
            P  P L T        L E S     +K L   L+ +++ L G            Q AG 
Sbjct: 470  PDLPSLHTFLPQIEAALMESS----RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGS 525

Query: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
            +   +LL    L ++ +++  L + + F +    +   L D +  ++  + L+   D+  
Sbjct: 526  MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ--RDLPG 583

Query: 8478 IELQIKKLKELQK 8490
             + Q+ +L+ LQ+
Sbjct: 584  KQAQLSRLQGLQE 596



 Score = 47.0 bits (110), Expect = 8e-04
 Identities = 73/378 (19%), Positives = 145/378 (38%), Gaps = 60/378 (15%)

Query: 1632 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1691
            ++ Q+E+ +       + +E +  HW         F  W ++       P +++     +
Sbjct: 90   IKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLE-PHIELQLGLKE 148

Query: 1692 VEGELQLIQALQNEVVSQASFYSKLLQLKESLFS-----VASKDDVKMMKLHLEQLDERW 1746
             + +L   Q L + V +QA    +LL+   SLF+        +D  K MK   + +  + 
Sbjct: 149  KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK- 207

Query: 1747 RDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRH 1806
                    KR++ L+ V  EH+++   +  F +W+                         
Sbjct: 208  ------AQKRVDLLEQVAREHEEYQAGVDEFQLWL------------------------- 236

Query: 1807 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLA 1866
                      K  ++ + G L +   L   + L  LQ  A+D F   EE+ + +E +   
Sbjct: 237  ----------KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKD-FPRGEESLETLEEQSAG 285

Query: 1867 LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSL 1926
            +      L +   ++G L ++R+ +E   ++ + E    E+ L   L++  A E     L
Sbjct: 286  VIRNTSPLGAE-KITGELEEMRKVLEKLRALWEEE----EERLRGLLRSRGAWEQQIKQL 340

Query: 1927 DGILSKAQYHLKIGSSE--QRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ 1984
            +  LS+ +  L+  + E  Q  +   T D+L     R         SE   +  L    Q
Sbjct: 341  EAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRL----Q 396

Query: 1985 DQKEELLKSIEDIEERTD 2002
             Q +EL+    +++  +D
Sbjct: 397  AQLKELIVFPHNLKPLSD 414



 Score = 45.8 bits (107), Expect = 0.002
 Identities = 144/812 (17%), Positives = 323/812 (39%), Gaps = 96/812 (11%)

Query: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
            + F +S+E  +AW+   ++ LQ  D +     + ++ R+ E +    K   + P+     
Sbjct: 7    DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPR-AALEARLWETE----KICQLEPEGRVRV 61

Query: 7415 ELGYRL--------PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 7464
            +L  R+        P + K   + R++++   W    +  T   S+++   L        
Sbjct: 62   DLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLH------- 114

Query: 7465 CETWMEFLVQTE------QKLAVEISGNYQHLLE-QQRAHELFQAEMFSRQQILHSIIID 7517
               W E+L+  +      QK+ V +  + +  L  +++  +L  A++        ++++D
Sbjct: 115  ---WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171

Query: 7518 GQRLLEQG----------QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7567
              RLLE+            VD+  +  +K      ++  V  +AQ+R  +++   R+ + 
Sbjct: 172  --RLLEEAASLFNRIGDPSVDEDAQKRMKA-----EYDAVKAKAQKRVDLLEQVAREHEE 224

Query: 7568 YREMAEKLRKWLVEVSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7626
            Y+   ++ + WL  V       LG +  +P+ Q  +   ++    K F R + S     E
Sbjct: 225  YQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDI---AKDFPRGEESLETLEE 281

Query: 7627 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIA 7683
                ++ +        +  EL E+++  +      EE++++L  LL+    WE+  K + 
Sbjct: 282  QSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLE 341

Query: 7684 DSLEKLRTFKKKLSQ------SLPDHHEELHAEQMRCKELENAVGSWTDDLTQL-SLLKD 7736
              L + R   ++L+Q      +     +EL A   R      A+ S    + +L + LK+
Sbjct: 342  AELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE 401

Query: 7737 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW- 7795
             +   +   ++  L++ V    ++++ L  ++   R +    +  W  F    ++L  W 
Sbjct: 402  LI---VFPHNLKPLSDSVIATIQEYQSL--KVKSARLRNAAAVELWQHFQRPLQDLQLWK 456

Query: 7796 -LTQMESKVSQNGDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7852
             L Q   +V+ +   L  +   + +++    E   + +E    LQ   + L     + +A
Sbjct: 457  ALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRL-KELLTMLQLKKDLLIGIFGQERA 515

Query: 7853 SE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL--AHIESELA 7909
            +  +E   G + DR   L + +  R  KL+  L   +        L+  L    +  +  
Sbjct: 516  TALLEQVAGSMRDR-DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAE 574

Query: 7910 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 7969
            K +  D    +    +L   QE   D+         ++       H  D  ++D +  ++
Sbjct: 575  KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ--AL 632

Query: 7970 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL-KSSERTAAFPSSS 8028
            Q++  +L  R    C  S++              F         W+  ++++  A    +
Sbjct: 633  QRSLEDLVDR----CRQSVQEHC----------TFSHQLLELRQWIVVTTQKLEAHRGEA 678

Query: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 8088
            G     A+ +  +FE    +  E   QL L+  Q   +  ++  + A  +++ + E  + 
Sbjct: 679  GP--GDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAES 736

Query: 8089 WDNLQKRVTSILRRLKHFIGQREEFETARDSI 8120
            W  L+    S+L  ++++  QR E ++ +  +
Sbjct: 737  WRALRLLEESLLSLIRNWHLQRMEVDSGKKMV 768



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 82/429 (19%), Positives = 166/429 (38%), Gaps = 64/429 (14%)

Query: 1403 ASEIPLGPQNKQLLQQQAKSIKEQV-----KKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1457
            A + P G ++ + L++Q+  +         +K+   LEE  K +E ++  W+        
Sbjct: 266  AKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE-------- 317

Query: 1458 LSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV--GLEEEAQSFAQFVT 1515
                  E+E+ L  L  S  A + QI Q++  + E    L  +   GL+  A++  +   
Sbjct: 318  ------EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371

Query: 1516 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSV-SEFEDK 1574
                 R  A  T+     EE R         +   L +   F  NL+ +  SV +  ++ 
Sbjct: 372  VAHWRRYSA--TRAALASEEPRVDR------LQAQLKELIVFPHNLKPLSDSVIATIQEY 423

Query: 1575 LAVPIKIC----SSATETYKVLQEHMDLCQALESLSSAITAFSASA-------------R 1617
             ++ +K      ++A E ++  Q  +   Q  ++L+  +   +AS               
Sbjct: 424  QSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483

Query: 1618 KVVNRDSCVQEAAALQQQYEDILRR--AKERQTALENLLAHWQRLEKELSSFLTWLERGE 1675
              +   S ++E   + Q  +D+L     +ER TAL   +A   R    L + L   +   
Sbjct: 484  AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543

Query: 1676 AKASSPEMDISADRVKVEGEL-------QLIQALQNEVVSQASFYSKLLQLKESLFSVAS 1728
                +   D  A    ++ +L       Q  + LQ ++  + +  S+L  L+E    + +
Sbjct: 544  QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGA 603

Query: 1729 KDDVKMMKLH--------LEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780
            + +     +         ++QL   ++ L + +   ++  +  V EH  F   LL    W
Sbjct: 604  QMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQW 663

Query: 1781 IKLFLSELQ 1789
            I +   +L+
Sbjct: 664  IVVTTQKLE 672



 Score = 43.9 bits (102), Expect = 0.007
 Identities = 127/632 (20%), Positives = 245/632 (38%), Gaps = 101/632 (15%)

Query: 5103 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5162
            W +Y  AR+E           L     L+     E + +LS  + L+  V++    +  L
Sbjct: 115  WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK-EKQWQLSHAQVLLHNVDNQAVLLDRL 173

Query: 5163 -EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVK 5221
             EE AS   + G+ +      + M      +  ++A AQ +  +LE    E   +   V 
Sbjct: 174  LEEAASLFNRIGDPSVDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230

Query: 5222 KATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQD 5281
            +    +  + +K+ G       K  +   L        +  + + +L  L +Q+  ++++
Sbjct: 231  EFQLWLKAVVEKVNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRN 289

Query: 5282 GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5341
             +       P   ++IT   +    + EK++   +      ++ E +   + S   W Q+
Sbjct: 290  TS-------PLGAEKITGELEEMRKVLEKLRALWE------EEEERLRGLLRSRGAWEQQ 336

Query: 5342 TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLA 5401
             K+        ++A+L E +++L      ++ ++  A+   E  L  +       S   A
Sbjct: 337  IKQ--------LEAELSEFRMVLQRLA--QEGLQPAAKAGTEDELVAHW---RRYSATRA 383

Query: 5402 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVV---QA 5458
             +A +    D++Q ++KE                     L      LK  +D+V+   Q 
Sbjct: 384  ALASEEPRVDRLQAQLKE---------------------LIVFPHNLKPLSDSVIATIQE 422

Query: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5518
                KV    L   N+  +EL    Q+ L Q+ QL K LA+++ ++T     ++    + 
Sbjct: 423  YQSLKVKSARLR--NAAAVELWQHFQRPL-QDLQLWKALAQRLLEVTA----SLPDLPSL 475

Query: 5519 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY--------ILHQ 5570
             + L Q  + L E + + EL L  ++  K L  G      A+ L EQ         +LH 
Sbjct: 476  HTFLPQIEAALMESSRLKEL-LTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHN 534

Query: 5571 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 5627
            +LL+   ++ S L                     Q  + G   E L++ +   ++R+Q  
Sbjct: 535  SLLQRKSKLQSLLA--------------------QHKDFGAAFEPLQRKLLDLQVRVQAE 574

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ 5687
            +   +D+   +A+L +LQ   E+        E  R  ++E  +H QH   +M+ L    Q
Sbjct: 575  KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH-QH---KMDQLSSDFQ 630

Query: 5688 AVQLCQSAL--RIPEDVVASLPLCHAALRLQE 5717
            A+Q     L  R  + V       H  L L++
Sbjct: 631  ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQ 662



 Score = 40.4 bits (93), Expect = 0.078
 Identities = 87/448 (19%), Positives = 187/448 (41%), Gaps = 40/448 (8%)

Query: 5346 LGNPTIEIDAQLE---ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5402
            +G+P+++ DAQ     E   +  +A      +E++A E +E   G+      E  L L  
Sbjct: 184  IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV-----DEFQLWLKA 238

Query: 5403 VALDLKIRDQIQDKIK-EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5461
            V    K+   +    K  + Q  +T Q++++   +  + L T    L+ ++  V+  +  
Sbjct: 239  VVE--KVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLET----LEEQSAGVI--RNT 290

Query: 5462 QKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSK 5521
              +  E++ G   ++ ++   ++   E+  +  + L +  G      +Q I+Q E  LS+
Sbjct: 291  SPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAW----EQQIKQLEAELSE 346

Query: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
                   L +  E L+   K   + +++AH    W   S  R      +  ++  +    
Sbjct: 347  FRMVLQRLAQ--EGLQPAAKAGTEDELVAH----WRRYSATRAALASEEPRVDRLQAQLK 400

Query: 5582 ELEAMTEKLQYLT-SVYCTEKMSQQVAELGRETEELRQMIKIRL-QNLQDAAKDMKKFEA 5639
            EL      L+ L+ SV  T    Q+   L  ++  LR    + L Q+ Q   +D++ ++A
Sbjct: 401  ELIVFPHNLKPLSDSVIAT---IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457

Query: 5640 ELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIP 5699
              ++L       + T + P++   SL   L   +  L E   LK  +  +QL +  L   
Sbjct: 458  LAQRL------LEVTASLPDLP--SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509

Query: 5700 EDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHR 5759
                 +  L         +   L ++ +Q+ + +Q+ + Q++ +    + LQ+ +     
Sbjct: 510  FGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569

Query: 5760 EIEDKPVATSNIQELQAQISRHEELAQK 5787
             ++ +     ++   QAQ+SR + L ++
Sbjct: 570  RVQAEKGLQRDLPGKQAQLSRLQGLQEE 597



 Score = 38.5 bits (88), Expect = 0.30
 Identities = 94/549 (17%), Positives = 221/549 (40%), Gaps = 65/549 (11%)

Query: 4876 VTECESRM----VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4931
            +T C SR+    +   ++         W +++   L   + L L L++ Q ++   Q+  
Sbjct: 101  MTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL 160

Query: 4932 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4991
              V +   +++ L  +    F +  +  S D +      +E D     A++ +     ++
Sbjct: 161  HNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMKAEYD-----AVKAKAQKRVDL 214

Query: 4992 YSQCQRYYQVFQAAND----WLEDAQELLQ--LAGN-GLDVESAEENLKSHMEFFSTEDQ 5044
              Q  R ++ +QA  D    WL+   E +   L  N  L +      L+   + F   ++
Sbjct: 215  LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274

Query: 5045 FHSNLEELHS-LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5103
                LEE  + ++    PL       +LE+    LE + + +  +   ++  L R    W
Sbjct: 275  SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLE-KLRALWEEEEERLRGLLRSRGAW 333

Query: 5104 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE---HKALVSVVNSFHEKIV 5160
                K  E  +       ++L++  L   + +   +E ++    + A  + + S   ++ 
Sbjct: 334  EQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVD 393

Query: 5161 ALEEKASQLE------KTGNDASKATLSRSMTTVWQRWTRLRAVA-----QDQEKILEDA 5209
             L+ +  +L       K  +D+  AT+ +   ++  +  RLR  A     Q  ++ L+D 
Sbjct: 394  RLQAQLKELIVFPHNLKPLSDSVIATI-QEYQSLKVKSARLRNAAAVELWQHFQRPLQD- 451

Query: 5210 VDEWTGFNNKVKKATEMIDQLQD------KLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5263
            +  W     ++ + T  +  L        ++  +  E +   ELLT+L+     ++ +  
Sbjct: 452  LQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511

Query: 5264 QQSALGMLRQQTLSM-----LQDGAAPTPGEEPPLMQE-------ITAMQDRCLNMQEKV 5311
            Q+ A  +L Q   SM     L +       +   L+ +          +Q + L++Q +V
Sbjct: 512  QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571

Query: 5312 KTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHR 5371
            +   K ++++L  ++   +++  ++              +++ AQ+E  + L+ E  NH+
Sbjct: 572  QAE-KGLQRDLPGKQAQLSRLQGLQ-----------EEGLDLGAQMEAARPLVQENPNHQ 619

Query: 5372 QNIEKMAEE 5380
              +++++ +
Sbjct: 620  HKMDQLSSD 628



 Score = 33.9 bits (76), Expect = 7.3
 Identities = 123/705 (17%), Positives = 259/705 (36%), Gaps = 79/705 (11%)

Query: 578  EEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN 637
            ++   ++  + +  AQW      +    S +E V  +W  Y         W +  + M+ 
Sbjct: 78   DQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ--KMMVT 135

Query: 638  QSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDE---MVSRDLKQQLLLLN------- 687
               + +         W   H  +      L+   D    ++ R L++   L N       
Sbjct: 136  LEPHIELQLGLKEKQWQLSHAQV------LLHNVDNQAVLLDRLLEEAASLFNRIGDPSV 189

Query: 688  -----GRWRELFMEVKQYAQ--ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFM 740
                  R +  +  VK  AQ   D ++++ +E+ +    +  F       + +       
Sbjct: 190  DEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGR 249

Query: 741  NVKLLI----QDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQL 796
            N KL I      L+DI +  P  +   + + + +  + + +     +++   + ++++ L
Sbjct: 250  NCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVL 309

Query: 797  TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
             K++  +       + LL      E+Q+      L +   ++  L +E    A       
Sbjct: 310  EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369

Query: 857  ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA----FQSMV 912
            EL+A       T   +      V +       L  F      + ++D  +A    +QS+ 
Sbjct: 370  ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLK 427

Query: 913  KKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD- 971
             K+   +        L + F+    +L+    +AQ  LE      +L   HT F  Q++ 
Sbjct: 428  VKSARLRNAAAV--ELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT-FLPQIEA 484

Query: 972  --------QRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1023
                    + +L       D L  I  ++    L E V    +    L          L+
Sbjct: 485  ALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544

Query: 1024 IDVEKNR-FLASVEEC-RTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLI 1081
              + +++ F A+ E   R  LD + ++  ++G ++ +   +   S          RLQ +
Sbjct: 545  SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLS----------RLQGL 594

Query: 1082 EELCVKL-----PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD-------Y 1129
            +E  + L       R  V++ P   H  + +L +   +  R L +  D+ +        +
Sbjct: 595  QEEGLDLGAQMEAARPLVQENPNHQH-KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653

Query: 1130 TSRFSEFSSWISTNETQLKGIKGEA---IDTANHGEVKRAVEEIRNGVTKRGETLSWLKS 1186
            + +  E   WI     +L+  +GEA      +   E +R V E      ++   LS +++
Sbjct: 654  SHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEF----PEKEAQLSLVEA 709

Query: 1187 RLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
            +  ++ E SS   A    +EL +L+ S++AL  L   +  ++ N+
Sbjct: 710  QGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNW 754


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  273 bits (698), Expect = 5e-72
 Identities = 597/2888 (20%), Positives = 1117/2888 (38%), Gaps = 509/2888 (17%)

Query: 12   RDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLS 71
            R I N +  L+DE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLS
Sbjct: 5    RAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLS 62

Query: 72   GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIIL 131
            G  LP E+GR   R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL
Sbjct: 63   GDSLPREKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120

Query: 132  YFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYT 191
            +FQI ++            S  S D                       AK+ LL W Q  
Sbjct: 121  HFQISDI----------QVSGQSEDM---------------------TAKEKLLLWSQRM 149

Query: 192  AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 251
                 G+   +F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG
Sbjct: 150  VEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLG 209

Query: 252  IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 311
            + RLLDPEDVDV +PDEKSI+TYV+      P + +   DG   +E+   +  +   V  
Sbjct: 210  VTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLL 268

Query: 312  F------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFR 355
                         +R     F+E+++   QF    E +L   +  ++  +  YQS +   
Sbjct: 269  LLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAV 328

Query: 356  VQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIG 415
               ++K     H +      GKL +   L ++   R      +   ++   L    G   
Sbjct: 329  QAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCE 387

Query: 416  AWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTD 457
              L +A+  L+ ++ +    +  + A  ++R L++   ++                Q   
Sbjct: 388  EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 447

Query: 458  AHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLEL 508
             ++R +  HE        Y  R   G+  P  Q+         V+  S     ++E   L
Sbjct: 448  MYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTL 500

Query: 509  KYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQY 556
            +Y L  LL   E              L S   + G    + Q ++ + + IE ++  E  
Sbjct: 501  RY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG- 558

Query: 557  EVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML---- 608
                Q+   T   Y    G ++      K +N + A+ R+L    S    + + ++    
Sbjct: 559  ----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNE 612

Query: 609  ---EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWI 654
               EEV  +W DR  N  A  +++      LE  EK + + +NA     R      P   
Sbjct: 613  KEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVE 672

Query: 655  QQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT 714
                A+    +++++ C   +   LK+     N  + + F +V++ A+            
Sbjct: 673  SFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------- 715

Query: 715  DCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLIT 774
                 L        +K S     +   ++ L+QD +D ++++         + K A  + 
Sbjct: 716  -----LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 770

Query: 775  KESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTS 826
            +  P+     M   +         +++  + K  EC         QL+ P +    ++ S
Sbjct: 771  QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLS 821

Query: 827  FYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLS 886
               S   +  +  ++    Q +                 ++ +T +E   Q++   VTL 
Sbjct: 822  SSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLW 861

Query: 887  NVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIA 946
            + L H D   L        +A+QS+ +     +       R +K  EE R  L  +    
Sbjct: 862  HQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHY 911

Query: 947  QEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAV 1001
            Q  L +  D     PE+ L    E+ S             C      L +  +QG QE  
Sbjct: 912  QAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEES 958

Query: 1002 R--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-E 1052
            R  +   + KD  LQ EA      H L L +D E  R      EC   +  + K   + E
Sbjct: 959  RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVE 1012

Query: 1053 GSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAI 1112
            G  K +                  RL    E  + LP   P   T          LR+ +
Sbjct: 1013 GLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSEL 1045

Query: 1113 DSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGE 1162
            + T  KL +       Y  +    S            +  +E QLK  +           
Sbjct: 1046 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1105

Query: 1163 VKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSS 1213
             K +++++R     +  T   L+  L+   EV           + E ++  + +A+L   
Sbjct: 1106 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165

Query: 1214 FKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTEN 1267
            ++A++      ++ L   G  ++Y     + L   +  ++  QEQ      A+     E 
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225

Query: 1268 LFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL--------------------- 1306
            L + Q LL   ++  +++   +R  +Q I   +  E  L                     
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285

Query: 1307 -PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHER 1365
              +   +E   L +    L     +  + I  TLR+ E  E   E       Q     ER
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER 1339

Query: 1366 FLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQA 1420
                  L  + + LE+ ++ ++       QAE   KE       E+    +     QQQ 
Sbjct: 1340 ------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393

Query: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
            +SI+E++++L  + E +I+         +      E     I     +L A E      +
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAE 1450

Query: 1481 MQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELR 1537
             ++  ++   +E E++       +EEA+   + V      + +A++   ++++   E  R
Sbjct: 1451 GELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507

Query: 1538 EHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1597
            E  + L+   L  L  Q   EE  R+++Q+  E   ++ V ++    + E          
Sbjct: 1508 EKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA--------- 1554

Query: 1598 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LE 1651
                   L S   +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E
Sbjct: 1555 ------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606

Query: 1652 NLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQAL 1702
              L  WQ         RL+ E  +    L + EA+    E +  A R    G+ +     
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVR 1663

Query: 1703 QNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQS 1762
            Q E+  Q     + L    +   +A++ ++  ++   EQ +++ + L + + +      +
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723

Query: 1763 VVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE--- 1812
               + Q+ +  L      +++ L+       E ++TSE S    +    R ++ A E   
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783

Query: 1813 ----VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCF 1850
                 E  K + Q  +   A            KL ++G A       ++ L + +AE+  
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-- 1841

Query: 1851 QLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN 1910
               E   ++ E        L E    H   + I  +L Q  +A++S  + +  L+E  L 
Sbjct: 1842 ---ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLR 1896

Query: 1911 DALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGE 1958
               Q  + + +   S +     KA+  L++G           S EQ     A   QL  E
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956

Query: 1959 VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQR 2017
             ER +     ++    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++
Sbjct: 1957 EERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013

Query: 2018 LRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHEN 2077
            L++  +                 K  Q  +K  AFA  V ++   L+ T    + ++ + 
Sbjct: 2014 LQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQL 2057

Query: 2078 QGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2136
            +G+         E +  +  A  +  ++   V       +  E+   A ++ + A  K+ 
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117

Query: 2137 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL 2196
             + +      ++ +      K+   ++    K   E T    L    ++E+ +  LR+ L
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQL 2173

Query: 2197 SIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALR 2250
               D   +  DE          + A   S ++  L     + EEL K +   E +N+AL 
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233

Query: 2251 LEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
            L +   K N  + L +  E    +    A L    + A  + ++A+   +D   Q    E
Sbjct: 2234 LRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAE 2287

Query: 2311 KFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNS 2365
            K + +       V+E+    A+ E  +     A ++ + +Q++ +     ++   +    
Sbjct: 2288 KMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2344

Query: 2366 LCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGA 2425
                    +LE    A    ++  E      S+ QA  +E  ++ F +  +E  E     
Sbjct: 2345 TLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRT 2398

Query: 2426 KAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSS 2484
            + A +E        ++   +  HD + + +++++ + + + + QE + L   L  + + +
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQT 2456

Query: 2485 IQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENL 2543
            +Q++             Q L++ QALQ    SE  S   + R +     ++E+ F  E +
Sbjct: 2457 VQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-V 2502

Query: 2544 GESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLT 2603
             +++Q   E++ +  ++E     L+A+ E     ++R Q  +EEG    QE         
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE--------- 2549

Query: 2604 SHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKR 2663
                L ++ +++ +  ++  +E++ L E LQ +    +A    LA +E    S+    K 
Sbjct: 2550 ---ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKT 2603

Query: 2664 LSQIQDIL 2671
            L   +D L
Sbjct: 2604 LPNGRDAL 2611



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 227  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 286

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 287  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 329

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 330  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 378

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 379  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 436  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 492

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 493  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 549

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 550  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 601

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 602  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 659

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 660  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 717

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 718  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 777

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 778  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 832

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 833  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 892

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 893  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 952

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 953  GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1007

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1008 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1065

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1126 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1246 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1303

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1304 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1359

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1360 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1397

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1442

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1443 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1492

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1493 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1547

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1608 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1648

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1702

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1759

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1812

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1867

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1868 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2028

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2029 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2086 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2203

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2264 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2375

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2376 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2421

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2422 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2462

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2463 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 525  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 579

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 580  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 635

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 636  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 674

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 675  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 713

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 714  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 753

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 754  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 810

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 811  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 863

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 864  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 923

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 924  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 982

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 983  HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1041

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1042 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1089

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1090 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1142

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1143 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1202

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1259

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1376

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1377 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1423

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1424 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1472

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1532

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1588

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1709 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1750

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1751 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1803

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1863

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1923

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2039

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2206

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2207 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2250

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2251 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2309

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2310 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2426

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2427 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2481

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2482 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2583



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1114 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1160

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1161 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1213 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1327

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1503

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1684 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1735

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1793

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 1974 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2022

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2083 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2117

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2118 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2226

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2227 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2286 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2341

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2342 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2384

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2434

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2488

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2489 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2544

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2601

Query: 6406 ALLP 6409
              LP
Sbjct: 2602 KTLP 2605



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1361

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1362 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1418

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1419 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1466

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1467 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1520

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1577

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1814

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1869

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2050 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2209

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2210 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2239

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2300 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2466 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2500

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1126 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1186 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1233

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1234 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1288

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1289 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1341

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1342 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1458 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1568

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1569 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1674

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1675 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1724 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1775

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1836 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1948 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 1999 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2035

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2093

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2131

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2180

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2181 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2237

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2238 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2287

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2288 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2332

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2393 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2446 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2551

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2610

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2611 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2651



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 370  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 426

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 427  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 479

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 480  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 536

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 537  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 591

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 592  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 649

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 650  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 706

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 707  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 766

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 767  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 826

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 827  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 884

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 885  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 940

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 941  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 996

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1050

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1165

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1286 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1341 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1389

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1390 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1508

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1559

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1607

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1658

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1659 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1702

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1703 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1755 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1873 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1925

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1926 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2028

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2029 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2086 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2191

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2192 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2251 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2297

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2298 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2357 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2415

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2416 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2463

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2464 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2519

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2520 E--QERQRLVA 2528



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 983  HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1036

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1095

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1096 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1155 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1199

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1200 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1240

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1241 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1277

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1278 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1331

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1389

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1390 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1424

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1533

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1652

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1700

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1701 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1743

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1744 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1863 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 1979

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2040 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2091

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2145

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2146 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2192

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2193 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2233

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2282

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2283 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2307

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2308 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2365

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2366 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2407

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2408 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2461

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2462 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2507

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2508 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2565 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2593



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1210

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1270

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1387

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1680

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1681 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1729

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1780

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1781 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1820

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1821 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1867

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1868 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1921 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1971

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2025

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2082

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2203 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2260 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2378

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2379 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2429

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2484

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2539

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2540 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2591 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2642

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2643 S-AEELQRLAQGHTTVDELA 2661



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1050 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1103

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1104 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1278

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1458

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1512

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1513 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1566

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1567 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1617

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1618 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1792

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1793 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1847

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1848 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1902

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1942

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2000

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2001 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2353 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2526

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2527 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2583 HRAALAHSEEVTASQVAATKT 2603



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 841  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 892

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 893  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 939

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 940  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 991

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 992  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1048

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1049 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1100

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1155

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1214

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1215 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1240

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1241 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1296

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1297 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1341

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1342 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1392

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1393 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1449

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1450 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1493

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1494 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1667

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1668 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1709

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1828

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1829 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1877

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 1989

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 1990 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2095

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2143

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2197

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2316

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2371

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2432 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2473

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2534 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1120 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1173 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1232

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1233 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1292

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1339

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1394

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1575 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1629 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1682

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1683 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1732 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1787

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1788 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1845

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1846 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1905

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1906 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1959

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 1960 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2013

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2074 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2132

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2133 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2192 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 957  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1004

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1005 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1062

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1121

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1163

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1164 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1219

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1272

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1392

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1511

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1512 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1566

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1567 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1624

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1685 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1795

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1796 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1845

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1846 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1890

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1891 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1923

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2041

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2042 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2084

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2139

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2192

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2253 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2304

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2345

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2346 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2399

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2400 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2441

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2442 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2483

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2484 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2534

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2535 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2569

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2570 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2623

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2624 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2680

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2681 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2711


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  270 bits (691), Expect = 4e-71
 Identities = 599/2898 (20%), Positives = 1121/2898 (38%), Gaps = 511/2898 (17%)

Query: 2    ATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGV 61
            A S G+   P + A +  R+ DE++ VQK+TFTKW+N HL K +    + DL+ED++DG 
Sbjct: 46   AGSNGSVLDPAERAVI--RIADERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGH 101

Query: 62   KLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSI 121
             L++LLEVLSG  LP E+GR   R H + N+  AL +L  R++KLVNI + DIADG P +
Sbjct: 102  NLISLLEVLSGDSLPREKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKL 159

Query: 122  VLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAK 181
             LGL+WTIIL+FQI ++            S  S D                       AK
Sbjct: 160  TLGLIWTIILHFQISDI----------QVSGQSEDM---------------------TAK 188

Query: 182  KALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLED 241
            + LL W Q       G+   +F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ 
Sbjct: 189  EKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQ 248

Query: 242  AFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPG 301
            AF++AE +LG+ RLLDPEDVDV +PDEKSI+TYV+      P + +   DG   +E+   
Sbjct: 249  AFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLR 307

Query: 302  FPSFANSVQNF------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQ 345
            +  +   V               +R     F+E+++   QF    E +L   +  ++  +
Sbjct: 308  WQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSK 367

Query: 346  DKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDK 405
              YQS +      ++K     H +      GKL +   L ++   R      +   ++  
Sbjct: 368  GIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVT 426

Query: 406  SLPAPLGTIGAWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL---------- 453
             L    G     L +A+  L+ ++ +    +  + A  ++R L++   ++          
Sbjct: 427  KLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL 486

Query: 454  ------QNTDAHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSEL 498
                  Q    ++R +  HE        Y  R   G+  P  Q+         V+  S  
Sbjct: 487  KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQ 539

Query: 499  HLMKMEFLELKYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSF 546
               ++E   L+Y L  LL   E              L S   + G    + Q ++ + + 
Sbjct: 540  RRPELEDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 598

Query: 547  IENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVR 602
            IE ++  E      Q+   T   Y    G ++      K +N + A+ R+L    S    
Sbjct: 599  IERARSDEG-----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAA 651

Query: 603  SVRSML-------EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFR 648
            + + ++       EEV  +W DR  N  A  +++      LE  EK + + +NA     R
Sbjct: 652  ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLR 711

Query: 649  N----LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQAD 704
                  P       A+    +++++ C   +   LK+     N  + + F +V++ A+  
Sbjct: 712  EDHPARPTVESFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ 764

Query: 705  EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYK 764
                           L        +K S     +   ++ L+QD +D ++++        
Sbjct: 765  ---------------LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 809

Query: 765  IITKTAHLITKESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIP 816
             + K A  + +  P+     M   +         +++  + K  EC         QL+ P
Sbjct: 810  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGP 860

Query: 817  LEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGS 876
             +    ++ S   S   +  +  ++    Q +                 ++ +T +E   
Sbjct: 861  AQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQH 903

Query: 877  QSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESR 936
            Q++   VTL + L H D   L        +A+QS+ +     +       R +K  EE R
Sbjct: 904  QAL---VTLWHQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQR 950

Query: 937  AELEKVLRIAQEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPE 991
              L  +    Q  L +  D     PE+ L    E+ S             C      L +
Sbjct: 951  QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQ 997

Query: 992  QEQQGLQEAVR--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELD 1043
              +QG QE  R  +   + KD  LQ EA      H L L +D E  R      EC   + 
Sbjct: 998  SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIA 1051

Query: 1044 RETKLMPQ-EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCH 1102
             + K   + EG  K +                  RL    E  + LP   P   T     
Sbjct: 1052 EQQKAQAEVEGLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT----- 1089

Query: 1103 VTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKG 1152
                 LR+ ++ T  KL +       Y  +    S            +  +E QLK  + 
Sbjct: 1090 -----LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144

Query: 1153 EAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQ 1203
                       K +++++R     +  T   L+  L+   EV           + E ++ 
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204

Query: 1204 GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ----- 1258
             + +A+L   ++A++      ++ L   G  ++Y     + L   +  ++  QEQ     
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 1259 -AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------- 1306
             A+     E L + Q LL   ++  +++   +R  +Q I   +  E  L           
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324

Query: 1307 -----------PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
                        +   +E   L +    L     +  + I  TLR+ E  E   E     
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ---- 1380

Query: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGP 1410
              Q     ER      L  + + LE+ ++ ++       QAE   KE       E+    
Sbjct: 1381 --QRAEERER------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432

Query: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
            +     QQQ +SI+E++++L  + E +I+         +      E     I     +L 
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLE 1489

Query: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---T 1527
            A E      + ++  ++   +E E++       +EEA+   + V      + +A++   +
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELAS 1546

Query: 1528 QIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1587
            +++   E  RE  + L+   L  L  Q   EE  R+++Q+  E   ++ V ++    + E
Sbjct: 1547 RVKAEAEAAREKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAE 1602

Query: 1588 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1647
                             L S   +F+    ++    S  +E  A+ Q  E+  RRA+++ 
Sbjct: 1603 A---------------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQA 1645

Query: 1648 TA------LENLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1692
             A       E  L  WQ         RL+ E  +    L + EA+    E +  A R   
Sbjct: 1646 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR--- 1702

Query: 1693 EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQI 1752
             G+ +     Q E+  Q     + L    +   +A++ ++  ++   EQ +++ + L + 
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762

Query: 1753 INKRINFLQSVVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTR 1805
            + +      +   + Q+ +  L      +++ L+       E ++TSE S    +    R
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822

Query: 1806 HKDHAAE-------VESKKGELQSLQGHLA------------KLGSLGRA------EDLH 1840
             ++ A E        E  K + Q  +   A            KL ++G A       ++ 
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882

Query: 1841 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1900
            L + +AE+     E   ++ E        L E    H   + I  +L Q  +A++S  + 
Sbjct: 1883 LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELER 1935

Query: 1901 ESDLIEKDLNDALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSC 1948
            +  L+E  L    Q  + + +   S +     KA+  L++G           S EQ    
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1995

Query: 1949 RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLK 2007
             A   QL  E ER +     ++    +LA  ++A + Q++  L+ +E ++ + ++  RL+
Sbjct: 1996 AARQRQLAAEEERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLR 2052

Query: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTW 2067
            E   Q   ++L++  +                 K  Q  +K  AFA  V ++   L+ T 
Sbjct: 2053 ERAEQESARQLQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTL 2096

Query: 2068 DDTKRLIHENQGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFS 2126
               + ++ + +G+         E +  +  A  +  ++   V       +  E+   A +
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156

Query: 2127 KHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLE 2186
            + + A  K+  + +      ++ +      K+   ++    K   E T    L    ++E
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVE 2212

Query: 2187 ENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EF 2240
            + +  LR+ L   D   +  DE          + A   S ++  L     + EEL K + 
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272

Query: 2241 ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLK 2300
              E +N+AL L +   K N  + L +  E    +    A L    + A  + ++A+   +
Sbjct: 2273 RIEAENRALILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---E 2326

Query: 2301 DFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSN 2355
            D   Q    EK + +       V+E+    A+ E  +     A ++ + +Q++ +     
Sbjct: 2327 DLAQQRALAEKMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2383

Query: 2356 ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESM 2415
            ++   +            +LE    A    ++  E      S+ QA  +E  ++ F +  
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQA 2437

Query: 2416 QEFQEWFLGAKAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
            +E  E     + A +E        ++   +  HD + + +++++ + + + + QE + L 
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL- 2496

Query: 2475 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHE 2533
              L  + + ++Q++             Q L++ QALQ    SE  S   + R +     +
Sbjct: 2497 -QLKSEEMQTVQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542

Query: 2534 MEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ 2593
            +E+ F  E + +++Q   E++ +  ++E     L+A+ E     ++R Q  +EEG    Q
Sbjct: 2543 LEQLFQDE-VAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQ 2597

Query: 2594 EGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST 2653
            E             L ++ +++ +  ++  +E++ L E LQ +    +A    LA +E  
Sbjct: 2598 E------------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEV 2642

Query: 2654 LGSKDTLEKRLSQIQDIL 2671
              S+    K L   +D L
Sbjct: 2643 TASQVAATKTLPNGRDAL 2660



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 276  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 335

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 336  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 378

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 379  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 427

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 428  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 484

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 485  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 541

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 542  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 598

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 599  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 650

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 651  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 708

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 709  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 766

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 767  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 826

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 827  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 881

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 882  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 941

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 942  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1001

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 1002 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1056

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1057 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1114

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1175 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1295 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1352

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1353 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1408

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1409 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1446

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1491

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1492 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1541

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1542 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1596

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1657 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1697

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1751

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1808

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1861

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1916

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1917 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2077

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2078 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2135 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2192

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2313 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2424

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2425 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2470

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2471 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2511

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2512 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 574  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 628

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 629  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 684

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 685  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 723

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 724  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 762

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 763  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 802

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 803  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 859

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 860  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 912

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 913  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 972

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 973  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1031

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1090

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1138

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1139 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1191

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1192 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1251

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1308

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1425

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1426 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1472

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1473 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1521

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1581

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1637

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1758 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1799

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1800 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1852

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1912

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1972

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2088

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2255

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2256 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2299

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2300 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2358

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2359 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2475

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2476 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2530

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2531 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2632



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1163 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1209

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1210 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1262 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1552

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1733 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1784

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1842

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 2023 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2071

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2132 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2166

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2167 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2275

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2276 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2335 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2390

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2391 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2433

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2483

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2537

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2538 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2593

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2650

Query: 6406 ALLP 6409
              LP
Sbjct: 2651 KTLP 2654



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1410

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1411 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1467

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1468 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1515

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1516 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1569

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1626

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1863

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1864 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1918

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2099 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2258

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2259 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2288

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2349 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2515 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2549

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1175 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1235 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1282

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1283 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1337

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1338 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1390

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1391 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1507 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1617

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1618 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1723

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1724 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1772

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1773 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1824

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1884

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1885 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1997 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 2048 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2084

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2142

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2180

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2229

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2230 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2286

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2287 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2336

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2337 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2381

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2442 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2495 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2600

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2601 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2659

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2660 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2700



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 419  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 475

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 476  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 528

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 529  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 585

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 586  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 640

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 641  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 698

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 699  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 755

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 756  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 815

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 816  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 875

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 876  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 933

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 934  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 989

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 990  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1045

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1099

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1214

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1335 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1390 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1438

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1439 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1557

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1608

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1656

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1707

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1708 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1751

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1752 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1804 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1922 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1974

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1975 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2077

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2078 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2135 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2192

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2240

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2241 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2300 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2346

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2347 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2406 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2464

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2465 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2512

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2513 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2568

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2569 E--QERQRLVA 2577



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1085

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1086 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1144

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1145 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1204 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1248

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1249 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1289

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1290 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1326

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1327 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1380

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1438

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1439 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1473

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1582

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1701

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1749

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1750 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1792

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1793 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1912 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2028

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2089 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2140

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2194

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2195 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2241

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2242 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2282

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2331

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2332 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2356

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2357 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2414

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2415 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2456

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2457 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2510

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2511 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2556

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2557 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2614 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2642



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1259

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1319

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1436

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1729

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1730 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1778

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1829

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1830 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1869

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1870 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1916

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1917 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1970 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 2020

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2074

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2131

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2252 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2309 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2427

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2428 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2478

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2533

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2588

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2589 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2640 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2691

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2692 S-AEELQRLAQGHTTVDELA 2710



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1099 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1152

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1153 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1207

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1208 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1267

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1327

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1328 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1507

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1561

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1562 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1615

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1616 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1666

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1667 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1841

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1842 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1896

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1897 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1951

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1991

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2049

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2050 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2402 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2575

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2576 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2632 HRAALAHSEEVTASQVAATKT 2652



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 890  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 941

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 942  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 988

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 989  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1040

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1097

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1098 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1149

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1204

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1263

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1264 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1289

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1290 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1345

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1346 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1390

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1391 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1441

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1442 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1498

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1499 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1542

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1543 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1716

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1758

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1877

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1878 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1926

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2038

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 2039 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2144

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2192

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2246

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2365

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2420

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2481 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2522

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2583 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1169 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1222 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1281

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1282 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1341

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1388

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1443

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1503

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1624 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1678 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1731

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1732 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1781 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1836

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1837 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1894

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1895 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1954

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1955 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 2008

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 2009 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2062

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2123 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2181

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2182 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2241 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 1006 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1053

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1054 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1111

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1170

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1212

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1213 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1268

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1269 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1321

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1441

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1560

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1561 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1615

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1616 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1673

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1734 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1793 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1844

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1845 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1894

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1895 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1939

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1940 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1972

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2090

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2091 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2133

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2188

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2241

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2302 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2353

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2394

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2395 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2448

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2449 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2490

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2491 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2532

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2533 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2583

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2584 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2618

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2619 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2672

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2673 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2729

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2730 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  270 bits (690), Expect = 5e-71
 Identities = 594/2883 (20%), Positives = 1115/2883 (38%), Gaps = 509/2883 (17%)

Query: 17   VMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLP 76
            V ++ +DE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLSG  LP
Sbjct: 18   VREKYKDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLP 75

Query: 77   CEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIE 136
             E+GR   R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL+FQI 
Sbjct: 76   REKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 133

Query: 137  ELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQT 196
            ++            S  S D                       AK+ LL W Q       
Sbjct: 134  DI----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQ 162

Query: 197  GIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLL 256
            G+   +F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG+ RLL
Sbjct: 163  GLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLL 222

Query: 257  DPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF---- 312
            DPEDVDV +PDEKSI+TYV+      P + +   DG   +E+   +  +   V       
Sbjct: 223  DPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWM 281

Query: 313  --------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEM 360
                    +R     F+E+++   QF    E +L   +  ++  +  YQS +      ++
Sbjct: 282  RHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQL 341

Query: 361  KRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYR 420
            K     H +      GKL +   L ++   R      +   ++   L    G     L +
Sbjct: 342  KVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQ 400

Query: 421  AEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRA 462
            A+  L+ ++ +    +  + A  ++R L++   ++                Q    ++R 
Sbjct: 401  ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRV 460

Query: 463  F--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLL 513
            +  HE        Y  R   G+  P  Q+         V+  S     ++E   L+Y L 
Sbjct: 461  YRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQ 512

Query: 514  SLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
             LL   E              L S   + G    + Q ++ + + IE ++  E      Q
Sbjct: 513  DLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----Q 567

Query: 562  ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EE 610
            +   T   Y    G ++      K +N + A+ R+L    S    + + ++       EE
Sbjct: 568  LSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEE 625

Query: 611  VISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTA 659
            V  +W DR  N  A  +++      LE  EK + + +NA     R      P       A
Sbjct: 626  VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAA 685

Query: 660  MNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 719
            +    +++++ C   +   LK+     N  + + F +V++ A+                 
Sbjct: 686  LQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ--------------- 723

Query: 720  LSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQ 779
            L        +K S     +   ++ L+QD +D ++++         + K A  + +  P+
Sbjct: 724  LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPR 783

Query: 780  EEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSL 831
                 M   +         +++  + K  EC         QL+ P +    ++ S   S 
Sbjct: 784  HPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSE 834

Query: 832  GKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKH 891
              +  +  ++    Q +                 ++ +T +E   Q++   VTL + L H
Sbjct: 835  AAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-H 873

Query: 892  FDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 951
             D   L        +A+QS+ +     +       R +K  EE R  L  +    Q  L 
Sbjct: 874  VDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLR 924

Query: 952  EKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KL 1004
            +  D     PE+ L    E+ S             C      L +  +QG QE  R  + 
Sbjct: 925  DSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRC 971

Query: 1005 HKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKI 1057
              + KD  LQ EA      H L L +D E  R      EC   +  + K   + EG  K 
Sbjct: 972  ISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKG 1025

Query: 1058 IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR 1117
            +                  RL    E  + LP   P   T          LR+ ++ T  
Sbjct: 1026 V-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLG 1058

Query: 1118 KLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAV 1167
            KL +       Y  +    S            +  +E QLK  +            K ++
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118

Query: 1168 EEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALV 1218
            +++R     +  T   L+  L+   EV           + E ++  + +A+L   ++A++
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178

Query: 1219 TLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQ 1272
                  ++ L   G  ++Y     + L   +  ++  QEQ      A+     E L + Q
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1238

Query: 1273 QLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRG 1310
             LL   ++  +++   +R  +Q I   +  E  L                       +  
Sbjct: 1239 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESV 1298

Query: 1311 HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFS 1370
             +E   L +    L     +  + I  TLR+ E  E   E       Q     ER     
Sbjct: 1299 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER----- 1347

Query: 1371 SLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKE 1425
             L  + + LE+ ++ ++       QAE   KE       E+    +     QQQ +SI+E
Sbjct: 1348 -LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406

Query: 1426 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1485
            ++++L  + E +I+         +      E     I     +L A E      + ++  
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQA 1463

Query: 1486 IKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQC 1542
            ++   +E E++       +EEA+   + V      + +A++   ++++   E  RE  + 
Sbjct: 1464 LRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520

Query: 1543 LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL 1602
            L+   L  L  Q   EE  R+++Q+  E   ++ V ++    + E               
Sbjct: 1521 LQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA-------------- 1562

Query: 1603 ESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAH 1656
              L S   +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E  L  
Sbjct: 1563 -ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 1657 WQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1707
            WQ         RL+ E  +    L + EA+    E +  A R    G+ +     Q E+ 
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELA 1676

Query: 1708 SQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEH 1767
             Q     + L    +   +A++ ++  ++   EQ +++ + L + + +      +   + 
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736

Query: 1768 QQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------V 1813
            Q+ +  L      +++ L+       E ++TSE S    +    R ++ A E        
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796

Query: 1814 ESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEE 1855
            E  K + Q  +   A            KL ++G A       ++ L + +AE+     E 
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ER 1851

Query: 1856 ASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQN 1915
              ++ E        L E    H   + I  +L Q  +A++S  + +  L+E  L    Q 
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909

Query: 1916 AKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQ 1963
             + + +   S +     KA+  L++G           S EQ     A   QL  E ER +
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969

Query: 1964 NLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFN 2022
                 ++    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++L++  
Sbjct: 1970 R--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026

Query: 2023 QLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCC 2082
            +                 K  Q  +K  AFA  V ++   L+ T    + ++ + +G+  
Sbjct: 2027 E--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAE 2070

Query: 2083 GLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKD 2141
                   E +  +  A  +  ++   V       +  E+   A ++ + A  K+  + + 
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 2142 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDD 2201
                 ++ +      K+   ++    K   E T    L    ++E+ +  LR+ L   D 
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDH 2186

Query: 2202 VLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELH 2255
              +  DE          + A   S ++  L     + EEL K +   E +N+AL L +  
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD-- 2244

Query: 2256 SKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFIND 2315
             K N  + L +  E    +    A L    + A  + ++A+   +D   Q    EK + +
Sbjct: 2245 -KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE 2300

Query: 2316 ITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
                   V+E+    A+ E  +     A ++ + +Q++ +     ++   +         
Sbjct: 2301 ---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357

Query: 2371 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK 2430
               +LE    A    ++  E      S+ QA  +E  ++ F +  +E  E     + A +
Sbjct: 2358 RQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQ 2411

Query: 2431 ESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQI 2489
            E        ++   +  HD + + +++++ + + + + QE + L   L  + + ++Q++ 
Sbjct: 2412 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE- 2468

Query: 2490 TKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQ 2548
                        Q L++ QALQ    SE  S   + R +     ++E+ F  E + +++Q
Sbjct: 2469 ------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQ 2515

Query: 2549 HIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNL 2608
               E++ +  ++E     L+A+ E     ++R Q  +EEG    QE             L
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------EL 2559

Query: 2609 LRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQ 2668
             ++ +++ +  ++  +E++ L E LQ +    +A    LA +E    S+    K L   +
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGR 2616

Query: 2669 DIL 2671
            D L
Sbjct: 2617 DAL 2619



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 235  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 294

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 295  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 337

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 338  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 386

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 387  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 444  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 500

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 501  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 557

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 558  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 609

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 610  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 667

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 668  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 725

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 726  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 785

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 786  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 840

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 841  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 900

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 901  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 960

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 961  GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1015

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1016 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1073

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1134 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1254 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1311

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1312 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1367

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1368 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1405

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1450

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1451 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1500

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1501 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1555

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1616 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1656

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1710

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1767

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1820

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1875

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1876 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2036

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2037 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2094 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2151

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2211

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2272 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2383

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2384 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2429

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2430 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2470

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2471 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 533  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 587

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 588  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 643

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 644  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 682

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 683  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 721

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 722  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 761

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 762  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 818

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 819  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 871

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 872  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 931

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 932  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 990

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 991  HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1049

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1050 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1097

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1098 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1150

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1151 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1210

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1267

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1384

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1385 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1431

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1432 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1480

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1540

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1596

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1717 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1758

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1759 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1811

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1871

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1872 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1931

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2047

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2214

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2215 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2258

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2259 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2317

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2318 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2434

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2435 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2489

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2490 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2591



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1122 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1168

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1169 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1221 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1279

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1335

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1511

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1692 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1743

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1801

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 1982 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2030

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2091 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2125

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2126 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2234

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2235 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2294 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2349

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2350 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2392

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2442

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2496

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2497 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2552

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2609

Query: 6406 ALLP 6409
              LP
Sbjct: 2610 KTLP 2613



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1130

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1369

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1370 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1426

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1427 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1474

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1475 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1528

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1585

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1822

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1877

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2058 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2217

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2218 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2247

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2308 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2474 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2508

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1134 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1194 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1241

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1242 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1296

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1297 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1349

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1350 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1466 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1576

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1577 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1682

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1683 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1731

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1732 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1783

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1844 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1956 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 2007 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2043

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2101

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2139

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2188

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2189 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2245

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2246 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2295

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2296 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2340

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2401 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2454 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2559

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2618

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2619 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2659



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 378  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 434

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 435  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 487

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 488  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 544

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 545  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 599

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 600  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 657

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 658  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 714

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 715  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 774

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 775  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 834

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 835  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 892

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 893  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 948

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 949  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1004

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 1005 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1058

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1173

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1293

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1294 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1349 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1397

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1398 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1516

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1567

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1615

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1666

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1667 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1710

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1711 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1763 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1881 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1933

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1934 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2036

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2037 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2094 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2151

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2199

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2200 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2259 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2305

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2306 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2365 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2423

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2424 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2471

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2472 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2527

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2528 E--QERQRLVA 2536



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 991  HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1044

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1103

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1104 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1163 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1207

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1208 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1248

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1249 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1285

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1286 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1339

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1340 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1397

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1398 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1432

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1541

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1542 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1660

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1708

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1709 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1751

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1752 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1871 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 1987

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2048 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2099

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2153

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2154 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2200

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2201 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2241

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2290

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2291 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2315

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2316 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2373

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2374 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2415

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2416 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2469

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2470 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2515

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2516 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2573 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2601



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1218

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1278

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1395

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1688

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1689 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1737

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1788

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1789 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1828

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1829 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1875

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1876 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1929 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1979

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2033

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2090

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2211 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2268 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2327

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2386

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2387 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2437

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2492

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2547

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2548 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2599 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2650

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2651 S-AEELQRLAQGHTTVDELA 2669



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1058 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1111

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1112 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1166

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1167 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1226

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1286

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1287 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1346

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1466

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1520

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1521 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1574

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1575 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1625

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1626 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1800

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1801 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1855

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1856 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1910

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1950

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2008

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2009 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2361 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2534

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2535 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2591 HRAALAHSEEVTASQVAATKT 2611



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 849  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 900

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 901  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 947

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 948  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 999

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 1000 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1056

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1057 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1108

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1163

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1222

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1223 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1248

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1249 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1304

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1305 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1349

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1350 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1400

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1401 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1457

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1458 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1501

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1502 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1675

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1717

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1836

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1837 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1885

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 1997

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 1998 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2103

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2151

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2205

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2324

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2379

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2440 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2481

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2542 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1128 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1180

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1181 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1240

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1241 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1300

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1347

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1402

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1583 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1637 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1690

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1691 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1740 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1795

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1796 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1853

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1854 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1913

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1914 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1967

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 1968 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2021

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2082 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2140

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2141 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2200 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 965  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1012

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1013 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1070

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1129

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1171

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1172 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1227

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1228 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1280

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1400

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1519

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1520 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1574

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1575 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1632

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1693 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1803

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1804 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1853

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1854 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1898

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1899 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1931

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2049

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2050 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2092

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2147

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2148 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2200

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2261 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2312

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2353

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2354 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2407

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2408 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2449

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2450 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2491

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2492 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2542

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2543 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2577

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2578 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2631

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2632 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2688

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2689 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2719


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  269 bits (688), Expect = 8e-71
 Identities = 594/2878 (20%), Positives = 1112/2878 (38%), Gaps = 509/2878 (17%)

Query: 22   QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGR 81
            QDE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLSG  LP E+GR
Sbjct: 37   QDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94

Query: 82   RMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSN 141
               R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL+FQI ++   
Sbjct: 95   M--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI--- 149

Query: 142  LPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVK 201
                     S  S D                       AK+ LL W Q       G+   
Sbjct: 150  -------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCD 181

Query: 202  DFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDV 261
            +F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG+ RLLDPEDV
Sbjct: 182  NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDV 241

Query: 262  DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF--------- 312
            DV +PDEKSI+TYV+      P + +   DG   +E+   +  +   V            
Sbjct: 242  DVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTA 300

Query: 313  ---KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQI 365
               +R     F+E+++   QF    E +L   +  ++  +  YQS +      ++K    
Sbjct: 301  AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360

Query: 366  EHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVAL 425
             H +      GKL +   L ++   R      +   ++   L    G     L +A+  L
Sbjct: 361  YHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL 419

Query: 426  REEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE 465
            + ++ +    +  + A  ++R L++   ++                Q    ++R +  HE
Sbjct: 420  QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479

Query: 466  -------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVL 518
                    Y  R   G+  P  Q+         V+  S     ++E   L+Y L  LL  
Sbjct: 480  RLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAW 531

Query: 519  AESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQT 566
             E              L S   + G    + Q ++ + + IE ++  E      Q+   T
Sbjct: 532  VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPAT 586

Query: 567  AEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW 615
               Y    G ++      K +N + A+ R+L    S    + + ++       EEV  +W
Sbjct: 587  RGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644

Query: 616  -DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAG 664
             DR  N  A  +++      LE  EK + + +NA     R      P       A+    
Sbjct: 645  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704

Query: 665  NFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFA 724
            +++++ C   +   LK+     N  + + F +V++ A+                 L    
Sbjct: 705  SWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQ 742

Query: 725  TEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKE 784
                +K S     +   ++ L+QD +D ++++         + K A  + +  P+     
Sbjct: 743  EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 802

Query: 785  MFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
            M   +         +++  + K  EC         QL+ P +    ++ S   S   +  
Sbjct: 803  MRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPS 853

Query: 837  IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
            +  ++    Q +                 ++ +T +E   Q++   VTL + L H D   
Sbjct: 854  VCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKS 892

Query: 897  LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD- 955
            L        +A+QS+ +     +       R +K  EE R  L  +    Q  L +  D 
Sbjct: 893  L--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDA 943

Query: 956  ----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWK 1009
                PE+ L    E+ S             C      L +  +QG QE  R  +   + K
Sbjct: 944  GGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELK 990

Query: 1010 D--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHR 1062
            D  LQ EA      H L L +D E  R      EC   +  + K   + EG  K +    
Sbjct: 991  DIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV---- 1040

Query: 1063 VFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMED 1122
                          RL    E  + LP   P   T          LR+ ++ T  KL + 
Sbjct: 1041 -------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQV 1077

Query: 1123 PDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRN 1172
                  Y  +    S            +  +E QLK  +            K +++++R 
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1137

Query: 1173 GVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSE 1223
                +  T   L+  L+   EV           + E ++  + +A+L   ++A++     
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197

Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLH 1277
             ++ L   G  ++Y     + L   +  ++  QEQ      A+     E L + Q LL  
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELR 1315
             ++  +++   +R  +Q I   +  E  L                       +   +E  
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317

Query: 1316 KLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESL 1375
             L +    L     +  + I  TLR+ E  E   E       Q     ER      L  +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEV 1365

Query: 1376 SSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKL 1430
             + LE+ ++ ++       QAE   KE       E+    +     QQQ +SI+E++++L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 1431 EDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTI 1490
              + E +I+         +      E     I     +L A E      + ++  ++   
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 1491 QEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTI 1547
            +E E++       +EEA+   + V      + +A++   ++++   E  RE  + L+   
Sbjct: 1483 EEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-- 1537

Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSS 1607
            L  L  Q   EE  R+++Q+  E   ++ V ++    + E                 L S
Sbjct: 1538 LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQS 1580

Query: 1608 AITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ--- 1658
               +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E  L  WQ   
Sbjct: 1581 KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638

Query: 1659 ------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
                  RL+ E  +    L + EA+    E +  A R    G+ +     Q E+  Q   
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELE 1695

Query: 1713 YSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDE 1772
              + L    +   +A++ ++  ++   EQ +++ + L + + +      +   + Q+ + 
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 1773 LLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKG 1818
             L      +++ L+       E ++TSE S    +    R ++ A E        E  K 
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 1819 ELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVV 1860
            + Q  +   A            KL ++G A       ++ L + +AE+     E   ++ 
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLA 1870

Query: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
            E        L E    H   + I  +L Q  +A++S  + +  L+E  L    Q  + + 
Sbjct: 1871 EDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928

Query: 1921 SAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGT 1968
            +   S +     KA+  L++G           S EQ     A   QL  E ER +     
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EA 1986

Query: 1969 KQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDE 2027
            ++    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++L++  +    
Sbjct: 1987 EERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---- 2041

Query: 2028 LNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDL 2087
                         K  Q  +K  AFA  V ++   L+ T    + ++ + +G+       
Sbjct: 2042 ----------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 2088 MREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFT 2146
              E +  +  A  +  ++   V       +  E+   A ++ + A  K+  + +      
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 2147 SKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTR 2206
            ++ +      K+   ++    K   E T    L    ++E+ +  LR+ L   D   +  
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLL 2205

Query: 2207 DEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVND 2260
            DE          + A   S ++  L     + EEL K +   E +N+AL L +   K N 
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNT 2262

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
             + L +  E    +    A L    + A  + ++A+   +D   Q    EK + +     
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KM 2316

Query: 2321 TKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL 2375
              V+E+    A+ E  +     A ++ + +Q++ +     ++   +            +L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376

Query: 2376 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR 2435
            E    A    ++  E      S+ QA  +E  ++ F +  +E  E     + A +E    
Sbjct: 2377 EMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTL 2430

Query: 2436 TGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANE 2494
                ++   +  HD + + +++++ + + + + QE + L   L  + + ++Q++      
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------ 2482

Query: 2495 EFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK 2553
                   Q L++ QALQ    SE  S   + R +     ++E+ F  E + +++Q   E+
Sbjct: 2483 -------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQ 2534

Query: 2554 KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTK 2613
            + +  ++E     L+A+ E     ++R Q  +EEG    QE             L ++ +
Sbjct: 2535 QRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQ 2578

Query: 2614 EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
            ++ +  ++  +E++ L E LQ +    +A    LA +E    S+    K L   +D L
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2633



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 249  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 308

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 309  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 351

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 352  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 400

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 401  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 458  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 514

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 515  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 571

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 572  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 623

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 624  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 681

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 682  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 739

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 740  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 800  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 854

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 855  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 975  GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1029

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1030 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1268 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1381

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1419

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1464

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1465 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1514

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1515 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1569

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1630 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1670

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1724

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1781

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1834

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1889

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1890 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2050

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2051 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2108 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2286 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2397

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2398 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2443

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2444 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2484

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2485 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 547  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 601

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 602  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 658  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 696

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 697  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 735

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 736  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 775

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 776  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 832

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 833  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 885

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 886  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 945

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 946  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1004

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1063

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1111

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1112 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1281

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1398

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1399 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1445

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1446 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1494

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1610

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1731 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1772

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1773 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1825

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1945

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2061

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2228

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2229 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2272

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2273 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2448

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2449 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2503

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2504 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2605



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1136 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1182

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1183 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1235 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1525

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1706 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1757

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1815

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 1996 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2044

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2105 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2139

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2140 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2248

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2249 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2308 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2363

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2364 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2406

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2456

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2511 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2566

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2623

Query: 6406 ALLP 6409
              LP
Sbjct: 2624 KTLP 2627



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1384 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1441 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1488

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1489 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1542

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1599

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1836

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1891

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2072 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2231

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2232 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2261

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2322 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2488 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2522

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1208 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1255

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1256 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1311 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1363

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1364 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1480 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1590

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1591 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1696

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1697 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1746 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1858 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1970 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 2021 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2057

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2115

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2153

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2202

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2203 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2260 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2309

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2310 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2354

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2415 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2468 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2573

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2632

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2633 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 392  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 448

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 449  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 501

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 502  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 558

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 559  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 613

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 614  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 671

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 672  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 728

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 729  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 789  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 849  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 906

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 907  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 962

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 963  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1018

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1072

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1187

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1308 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1363 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1412 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1581

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1629

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1680

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1681 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1724

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1725 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1777 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1895 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1947

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1948 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2050

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2051 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2108 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2213

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2214 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2273 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2319

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2320 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2437

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2438 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2485

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2541

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2542 E--QERQRLVA 2550



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1058

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1117

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1118 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1177 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1221

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1222 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1262

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1263 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1299

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1300 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1353

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1411

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1412 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1446

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1555

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1674

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1722

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1723 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1765

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1766 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1885 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2001

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2062 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2113

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2167

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2168 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2214

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2215 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2255

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2304

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2305 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2329

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2330 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2387

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2388 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2429

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2430 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2483

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2484 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2529

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2530 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2587 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2615



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1409

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1702

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1703 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1751

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1802

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1803 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1842

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1843 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1889

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1890 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1943 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2047

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2104

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2400

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2401 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2451

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2506

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2561

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2562 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2613 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2664

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2665 S-AEELQRLAQGHTTVDELA 2683



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1125

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1126 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1534

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1535 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1588

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1589 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1639

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1640 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1814

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1870 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1924

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1964

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2022

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2023 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2375 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2548

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2549 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2605 HRAALAHSEEVTASQVAATKT 2625



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 863  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 914

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 915  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 961

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 962  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1013

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1070

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1071 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1177

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1236

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1237 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1262

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1263 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1318

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1319 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1363

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1364 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1414

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1415 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1471

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1472 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1516 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1689

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1731

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1850

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1851 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1899

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2011

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 2012 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2117

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2165

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2219

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2338

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2393

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2454 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2495

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2556 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1142 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1361

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1416

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1597 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1651 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1705 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1754 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1809

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1810 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1867

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1981

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 1982 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2035

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2096 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2155 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2214 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 979  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1026

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1084

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1143

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1185

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1186 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1294

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1534 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1588

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1589 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1646

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1707 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1817

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1818 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1867

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1868 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1912

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1913 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1945

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2063

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2064 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2161

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2214

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2275 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2326

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2367

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2368 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2421

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2422 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2463

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2464 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2505

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2506 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2556

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2557 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2591

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2645

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2702

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  268 bits (686), Expect = 1e-70
 Identities = 594/2882 (20%), Positives = 1114/2882 (38%), Gaps = 509/2882 (17%)

Query: 18   MQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPC 77
            M+ + DE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLSG  LP 
Sbjct: 1    MKIVPDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPR 58

Query: 78   EQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEE 137
            E+GR   R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL+FQI +
Sbjct: 59   EKGRM--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 116

Query: 138  LTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTG 197
            +            S  S D                       AK+ LL W Q       G
Sbjct: 117  I----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQG 145

Query: 198  IEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLD 257
            +   +F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG+ RLLD
Sbjct: 146  LRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205

Query: 258  PEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF----- 312
            PEDVDV +PDEKSI+TYV+      P + +   DG   +E+   +  +   V        
Sbjct: 206  PEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMR 264

Query: 313  -------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMK 361
                   +R     F+E+++   QF    E +L   +  ++  +  YQS +      ++K
Sbjct: 265  HHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLK 324

Query: 362  RKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRA 421
                 H +      GKL +   L ++   R      +   ++   L    G     L +A
Sbjct: 325  VPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQA 383

Query: 422  EVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF 463
            +  L+ ++ +    +  + A  ++R L++   ++                Q    ++R +
Sbjct: 384  DALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY 443

Query: 464  --HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLS 514
              HE        Y  R   G+  P  Q+         V+  S     ++E   L+Y L  
Sbjct: 444  RLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQD 495

Query: 515  LLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
            LL   E              L S   + G    + Q ++ + + IE ++  E      Q+
Sbjct: 496  LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QL 550

Query: 563  LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEV 611
               T   Y    G ++      K +N + A+ R+L    S    + + ++       EEV
Sbjct: 551  SPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEV 608

Query: 612  ISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAM 660
              +W DR  N  A  +++      LE  EK + + +NA     R      P       A+
Sbjct: 609  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAAL 668

Query: 661  NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTL 720
                +++++ C   +   LK+     N  + + F +V++ A+                 L
Sbjct: 669  QTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------L 706

Query: 721  SAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE 780
                    +K S     +   ++ L+QD +D ++++         + K A  + +  P+ 
Sbjct: 707  QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRH 766

Query: 781  EGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLG 832
                M   +         +++  + K  EC         QL+ P +    ++ S   S  
Sbjct: 767  PAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEA 817

Query: 833  KINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF 892
             +  +  ++    Q +                 ++ +T +E   Q++   VTL + L H 
Sbjct: 818  AVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HV 856

Query: 893  DQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEE 952
            D   L        +A+QS+ +     +       R +K  EE R  L  +    Q  L +
Sbjct: 857  DMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRD 907

Query: 953  KGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLH 1005
              D     PE+ L    E+ S             C      L +  +QG QE  R  +  
Sbjct: 908  SQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCI 954

Query: 1006 KQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKII 1058
             + KD  LQ EA      H L L +D E  R      EC   +  + K   + EG  K +
Sbjct: 955  SELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV 1008

Query: 1059 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1118
                              RL    E  + LP   P   T          LR+ ++ T  K
Sbjct: 1009 -----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGK 1041

Query: 1119 LMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVE 1168
            L +       Y  +    S            +  +E QLK  +            K +++
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101

Query: 1169 EIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVT 1219
            ++R     +  T   L+  L+   EV           + E ++  + +A+L   ++A++ 
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLA 1161

Query: 1220 LLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQ 1273
                 ++ L   G  ++Y     + L   +  ++  QEQ      A+     E L + Q 
Sbjct: 1162 QTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1221

Query: 1274 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGH 1311
            LL   ++  +++   +R  +Q I   +  E  L                       +   
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281

Query: 1312 EELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSS 1371
            +E   L +    L     +  + I  TLR+ E  E   E       Q     ER      
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------ 1329

Query: 1372 LESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQ 1426
            L  + + LE+ ++ ++       QAE   KE       E+    +     QQQ +SI+E+
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389

Query: 1427 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1486
            +++L  + E +I+         +      E     I     +L A E      + ++  +
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQAL 1446

Query: 1487 KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCL 1543
            +   +E E++       +EEA+   + V      + +A++   ++++   E  RE  + L
Sbjct: 1447 RARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503

Query: 1544 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE 1603
            +   L  L  Q   EE  R+++Q+  E   ++ V ++    + E                
Sbjct: 1504 QA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA--------------- 1544

Query: 1604 SLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHW 1657
             L S   +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E  L  W
Sbjct: 1545 ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602

Query: 1658 Q---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVS 1708
            Q         RL+ E  +    L + EA+    E +  A R    G+ +     Q E+  
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAE 1659

Query: 1709 QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1768
            Q     + L    +   +A++ ++  ++   EQ +++ + L + + +      +   + Q
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719

Query: 1769 QFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VE 1814
            + +  L      +++ L+       E ++TSE S    +    R ++ A E        E
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779

Query: 1815 SKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEA 1856
              K + Q  +   A            KL ++G A       ++ L + +AE+     E  
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERL 1834

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
             ++ E        L E    H   + I  +L Q  +A++S  + +  L+E  L    Q  
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1892

Query: 1917 KALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQN 1964
            + + +   S +     KA+  L++G           S EQ     A   QL  E ER + 
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952

Query: 1965 LLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQ 2023
                ++    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++L++  +
Sbjct: 1953 --EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2009

Query: 2024 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2083
                             K  Q  +K  AFA  V ++   L+ T    + ++ + +G+   
Sbjct: 2010 --------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEA 2053

Query: 2084 LIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDL 2142
                  E +  +  A  +  ++   V       +  E+   A ++ + A  K+  + +  
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE 2113

Query: 2143 DNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDV 2202
                ++ +      K+   ++    K   E T    L    ++E+ +  LR+ L   D  
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQ 2169

Query: 2203 LSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHS 2256
             +  DE          + A   S ++  L     + EEL K +   E +N+AL L +   
Sbjct: 2170 KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD--- 2226

Query: 2257 KVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2316
            K N  + L +  E    +    A L    + A  + ++A+   +D   Q    EK + + 
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE- 2282

Query: 2317 TTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYH 2371
                  V+E+    A+ E  +     A ++ + +Q++ +     ++   +          
Sbjct: 2283 --KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340

Query: 2372 SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKE 2431
              +LE    A    ++  E      S+ QA  +E  ++ F +  +E  E     + A +E
Sbjct: 2341 QRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQE 2394

Query: 2432 SSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQIT 2490
                    ++   +  HD + + +++++ + + + + QE + L   L  + + ++Q++  
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE-- 2450

Query: 2491 KANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQH 2549
                       Q L++ QALQ    SE  S   + R +     ++E+ F  E + +++Q 
Sbjct: 2451 -----------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQL 2498

Query: 2550 IPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLL 2609
              E++ +  ++E     L+A+ E     ++R Q  +EEG    QE             L 
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQ 2542

Query: 2610 RMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2669
            ++ +++ +  ++  +E++ L E LQ +    +A    LA +E    S+    K L   +D
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRD 2599

Query: 2670 IL 2671
             L
Sbjct: 2600 AL 2601



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 217  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 276

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 277  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 319

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 320  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 368

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 369  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 426  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 482

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 483  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 539

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 540  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 591

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 592  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 649

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 650  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 707

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 708  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 767

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 768  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 822

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 823  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 882

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 883  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 942

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 943  GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 997

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 998  -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1116 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1236 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1293

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1294 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1349

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1350 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1387

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1432

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1433 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1482

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1483 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1537

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1598 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1638

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1692

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1749

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1802

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1857

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1858 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2018

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2019 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2076 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2193

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2254 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2365

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2366 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2411

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2412 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2452

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2453 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 515  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 569

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 570  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 625

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 626  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 664

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 665  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 703

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 704  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 743

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 744  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 800

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 801  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 853

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 854  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 913

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 914  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 972

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 973  HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1031

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1032 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1079

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1080 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1132

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1133 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1192

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1249

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1366

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1367 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1413

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1414 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1462

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1522

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1578

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1699 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1740

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1741 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1793

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1853

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1854 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1913

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2029

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2196

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2197 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2240

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2241 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2299

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2300 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2416

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2417 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2471

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2472 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2573



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1104 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1150

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1151 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1203 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1261

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1317

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1493

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1674 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1725

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1783

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 1964 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2012

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2073 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2107

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2108 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2216

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2217 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2276 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2331

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2332 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2374

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2424

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2478

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2479 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2534

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2591

Query: 6406 ALLP 6409
              LP
Sbjct: 2592 KTLP 2595



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1112

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1351

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1352 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1408

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1409 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1456

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1457 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1510

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1567

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1804

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1859

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2040 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2199

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2200 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2229

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2290 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2456 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2490

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1116 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1176 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1223

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1224 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1278

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1279 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1331

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1332 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1448 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1558

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1559 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1664

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1665 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1714 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1765

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1826 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1938 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 1989 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2025

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2083

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2121

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2170

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2171 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2228 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2277

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2278 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2322

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2383 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2436 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2541

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2600

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2601 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2641



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 360  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 416

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 417  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 469

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 470  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 526

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 527  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 581

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 582  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 639

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 640  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 696

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 697  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 756

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 757  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 816

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 817  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 874

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 875  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 930

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 931  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 986

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 987  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1040

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1155

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1276 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1331 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1379

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1380 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1498

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1549

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1597

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1648

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1649 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1692

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1693 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1745 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1863 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1915

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1916 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2018

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2019 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2076 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2181

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2182 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2241 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2287

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2288 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2347 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2405

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2406 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2453

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2454 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2509

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2510 E--QERQRLVA 2518



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 973  HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1026

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1085

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1086 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1145 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1189

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1190 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1230

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1231 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1267

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1268 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1321

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1379

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1380 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1414

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1523

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1524 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1642

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1690

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1691 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1733

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1734 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1853 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 1969

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2030 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2081

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2135

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2136 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2182

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2183 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2223

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2272

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2273 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2297

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2298 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2355

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2356 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2397

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2398 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2451

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2452 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2497

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2498 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2555 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2583



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1200

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1260

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1377

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1670

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1671 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1719

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1770

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1771 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1810

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1811 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1857

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1858 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1911 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1961

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2015

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2072

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2193 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2250 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2309

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2368

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2369 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2419

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2474

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2529

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2530 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2581 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2632

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2633 S-AEELQRLAQGHTTVDELA 2651



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1040 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1093

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1094 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1268

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1328

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1448

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1502

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1503 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1556

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1557 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1607

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1608 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1782

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1783 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1837

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1838 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1892

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1932

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 1990

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 1991 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2343 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2516

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2517 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2573 HRAALAHSEEVTASQVAATKT 2593



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 831  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 882

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 883  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 929

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 930  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 981

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 982  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1038

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1039 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1145

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1204

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1205 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1230

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1231 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1286

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1287 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1331

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1332 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1382

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1383 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1439

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1440 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1483

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1484 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1657

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1699

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1818

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1819 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1867

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 1979

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 1980 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2085

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2133

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2187

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2306

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2361

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2422 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2463

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2524 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1110 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1162

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1163 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1222

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1223 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1282

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1329

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1384

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1565 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1619 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1672

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1673 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1722 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1777

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1778 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1835

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1836 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1895

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1896 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1949

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 1950 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2003

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2064 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2122

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2123 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2182 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 947  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 994

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 995  QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1052

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1111

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1153

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1154 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1209

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1262

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1501

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1502 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1556

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1557 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1614

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1675 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1785

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1786 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1835

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1836 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1880

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1881 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1913

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2031

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2032 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2074

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2129

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2130 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2182

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2243 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2294

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2335

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2336 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2389

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2390 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2431

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2432 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2473

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2474 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2524

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2525 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2559

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2560 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2613

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2614 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2670

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2671 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2701


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  268 bits (684), Expect = 2e-70
 Identities = 593/2878 (20%), Positives = 1112/2878 (38%), Gaps = 509/2878 (17%)

Query: 22   QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGR 81
            +DE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLSG  LP E+GR
Sbjct: 37   KDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94

Query: 82   RMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSN 141
               R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL+FQI ++   
Sbjct: 95   M--RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI--- 149

Query: 142  LPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVK 201
                     S  S D                       AK+ LL W Q       G+   
Sbjct: 150  -------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCD 181

Query: 202  DFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDV 261
            +F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG+ RLLDPEDV
Sbjct: 182  NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDV 241

Query: 262  DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF--------- 312
            DV +PDEKSI+TYV+      P + +   DG   +E+   +  +   V            
Sbjct: 242  DVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTA 300

Query: 313  ---KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQI 365
               +R     F+E+++   QF    E +L   +  ++  +  YQS +      ++K    
Sbjct: 301  AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360

Query: 366  EHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVAL 425
             H +      GKL +   L ++   R      +   ++   L    G     L +A+  L
Sbjct: 361  YHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL 419

Query: 426  REEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE 465
            + ++ +    +  + A  ++R L++   ++                Q    ++R +  HE
Sbjct: 420  QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479

Query: 466  -------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVL 518
                    Y  R   G+  P  Q+         V+  S     ++E   L+Y L  LL  
Sbjct: 480  RLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAW 531

Query: 519  AESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQT 566
             E              L S   + G    + Q ++ + + IE ++  E      Q+   T
Sbjct: 532  VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPAT 586

Query: 567  AEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW 615
               Y    G ++      K +N + A+ R+L    S    + + ++       EEV  +W
Sbjct: 587  RGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644

Query: 616  -DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAG 664
             DR  N  A  +++      LE  EK + + +NA     R      P       A+    
Sbjct: 645  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704

Query: 665  NFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFA 724
            +++++ C   +   LK+     N  + + F +V++ A+                 L    
Sbjct: 705  SWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQ 742

Query: 725  TEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKE 784
                +K S     +   ++ L+QD +D ++++         + K A  + +  P+     
Sbjct: 743  EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 802

Query: 785  MFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
            M   +         +++  + K  EC         QL+ P +    ++ S   S   +  
Sbjct: 803  MRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPS 853

Query: 837  IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
            +  ++    Q +                 ++ +T +E   Q++   VTL + L H D   
Sbjct: 854  VCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKS 892

Query: 897  LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD- 955
            L        +A+QS+ +     +       R +K  EE R  L  +    Q  L +  D 
Sbjct: 893  L--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDA 943

Query: 956  ----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWK 1009
                PE+ L    E+ S             C      L +  +QG QE  R  +   + K
Sbjct: 944  GGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELK 990

Query: 1010 D--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHR 1062
            D  LQ EA      H L L +D E  R      EC   +  + K   + EG  K +    
Sbjct: 991  DIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV---- 1040

Query: 1063 VFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMED 1122
                          RL    E  + LP   P   T          LR+ ++ T  KL + 
Sbjct: 1041 -------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQV 1077

Query: 1123 PDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRN 1172
                  Y  +    S            +  +E QLK  +            K +++++R 
Sbjct: 1078 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1137

Query: 1173 GVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSE 1223
                +  T   L+  L+   EV           + E ++  + +A+L   ++A++     
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197

Query: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLH 1277
             ++ L   G  ++Y     + L   +  ++  QEQ      A+     E L + Q LL  
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257

Query: 1278 HQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELR 1315
             ++  +++   +R  +Q I   +  E  L                       +   +E  
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317

Query: 1316 KLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESL 1375
             L +    L     +  + I  TLR+ E  E   E       Q     ER      L  +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEV 1365

Query: 1376 SSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKL 1430
             + LE+ ++ ++       QAE   KE       E+    +     QQQ +SI+E++++L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 1431 EDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTI 1490
              + E +I+         +      E     I     +L A E      + ++  ++   
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 1491 QEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTI 1547
            +E E++       +EEA+   + V      + +A++   ++++   E  RE  + L+   
Sbjct: 1483 EEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-- 1537

Query: 1548 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSS 1607
            L  L  Q   EE  R+++Q+  E   ++ V ++    + E                 L S
Sbjct: 1538 LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQS 1580

Query: 1608 AITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ--- 1658
               +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E  L  WQ   
Sbjct: 1581 KRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638

Query: 1659 ------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
                  RL+ E  +    L + EA+    E +  A R    G+ +     Q E+  Q   
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELE 1695

Query: 1713 YSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDE 1772
              + L    +   +A++ ++  ++   EQ +++ + L + + +      +   + Q+ + 
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 1773 LLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKG 1818
             L      +++ L+       E ++TSE S    +    R ++ A E        E  K 
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 1819 ELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVV 1860
            + Q  +   A            KL ++G A       ++ L + +AE+     E   ++ 
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLA 1870

Query: 1861 ERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALE 1920
            E        L E    H   + I  +L Q  +A++S  + +  L+E  L    Q  + + 
Sbjct: 1871 EDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928

Query: 1921 SAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGT 1968
            +   S +     KA+  L++G           S EQ     A   QL  E ER +     
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EA 1986

Query: 1969 KQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDE 2027
            ++    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++L++  +    
Sbjct: 1987 EERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---- 2041

Query: 2028 LNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDL 2087
                         K  Q  +K  AFA  V ++   L+ T    + ++ + +G+       
Sbjct: 2042 ----------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 2088 MREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFT 2146
              E +  +  A  +  ++   V       +  E+   A ++ + A  K+  + +      
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 2147 SKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTR 2206
            ++ +      K+   ++    K   E T    L    ++E+ +  LR+ L   D   +  
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLL 2205

Query: 2207 DEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVND 2260
            DE          + A   S ++  L     + EEL K +   E +N+AL L +   K N 
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNT 2262

Query: 2261 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2320
             + L +  E    +    A L    + A  + ++A+   +D   Q    EK + +     
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KM 2316

Query: 2321 TKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL 2375
              V+E+    A+ E  +     A ++ + +Q++ +     ++   +            +L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376

Query: 2376 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR 2435
            E    A    ++  E      S+ QA  +E  ++ F +  +E  E     + A +E    
Sbjct: 2377 EMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTL 2430

Query: 2436 TGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANE 2494
                ++   +  HD + + +++++ + + + + QE + L   L  + + ++Q++      
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------ 2482

Query: 2495 EFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK 2553
                   Q L++ QALQ    SE  S   + R +     ++E+ F  E + +++Q   E+
Sbjct: 2483 -------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQ 2534

Query: 2554 KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTK 2613
            + +  ++E     L+A+ E     ++R Q  +EEG    QE             L ++ +
Sbjct: 2535 QRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQ 2578

Query: 2614 EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
            ++ +  ++  +E++ L E LQ +    +A    LA +E    S+    K L   +D L
Sbjct: 2579 QRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2633



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 249  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 308

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 309  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 351

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 352  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 400

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 401  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 458  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 514

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 515  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 571

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 572  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 623

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 624  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 681

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 682  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 739

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 740  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 800  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 854

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 855  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 915  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 975  GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1029

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1030 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1268 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1381

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1419

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1464

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1465 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1514

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1515 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1569

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1630 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1670

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1724

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1781

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1834

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1889

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1890 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2050

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2051 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2108 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2286 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2397

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2398 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2443

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2444 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2484

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2485 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 547  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 601

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 602  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 658  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 696

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 697  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 735

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 736  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 775

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 776  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 832

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 833  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 885

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 886  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 945

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 946  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1004

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1063

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1111

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1112 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1281

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1398

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1399 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1445

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1446 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1494

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1554

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1610

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1731 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1772

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1773 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1825

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1885

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1945

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2061

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2228

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2229 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2272

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2273 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2448

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2449 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2503

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2504 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2605



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1136 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1182

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1183 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1235 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1525

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1706 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1757

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1815

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 1996 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2044

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2105 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2139

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2140 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2248

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2249 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2308 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2363

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2364 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2406

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2456

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2511 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2566

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2623

Query: 6406 ALLP 6409
              LP
Sbjct: 2624 KTLP 2627



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1383

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1384 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1441 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1488

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1489 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1542

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1599

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1836

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1891

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2072 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2231

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2232 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2261

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2322 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2488 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2522

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1208 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1255

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1256 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1311 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1363

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1364 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1480 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1590

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1591 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1696

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1697 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1746 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1858 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1970 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 2021 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2057

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2115

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2153

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2202

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2203 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2260 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2309

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2310 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2354

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2415 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2468 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2573

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2632

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2633 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 392  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 448

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 449  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 501

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 502  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 558

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 559  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 613

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 614  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 671

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 672  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 728

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 729  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 789  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 849  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 906

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 907  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 962

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 963  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1018

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1072

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1187

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1308 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1363 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1412 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1581

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1629

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1680

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1681 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1724

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1725 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1777 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1895 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1947

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1948 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2050

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2051 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2108 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2213

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2214 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2273 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2319

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2320 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2379 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2437

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2438 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2485

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2541

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2542 E--QERQRLVA 2550



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1058

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1117

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1118 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1177 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1221

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1222 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1262

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1263 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1299

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1300 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1353

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1411

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1412 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1446

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1555

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1674

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1722

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1723 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1765

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1766 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1885 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2001

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2062 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2113

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2167

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2168 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2214

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2215 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2255

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2304

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2305 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2329

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2330 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2387

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2388 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2429

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2430 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2483

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2484 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2529

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2530 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2587 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2615



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1409

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1702

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1703 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1751

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1802

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1803 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1842

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1843 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1889

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1890 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1943 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1993

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2047

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2104

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2400

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2401 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2451

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2506

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2561

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2562 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2613 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2664

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2665 S-AEELQRLAQGHTTVDELA 2683



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1072 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1125

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1126 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1360

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1534

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1535 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1588

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1589 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1639

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1640 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1814

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1869

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1870 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1924

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1964

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2022

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2023 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2375 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2548

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2549 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2605 HRAALAHSEEVTASQVAATKT 2625



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 863  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 914

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 915  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 961

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 962  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1013

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1070

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1071 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1177

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1236

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1237 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1262

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1263 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1318

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1319 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1363

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1364 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1414

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1415 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1471

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1472 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1516 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1689

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1731

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1850

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1851 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1899

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2011

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 2012 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2117

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2165

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2219

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2338

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2393

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2454 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2495

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2556 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1142 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1361

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1416

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1597 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1651 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1705 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1754 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1809

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1810 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1867

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1981

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 1982 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2035

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2096 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2154

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2155 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2214 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 979  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1026

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1084

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1143

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1185

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1186 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1294

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1534 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1588

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1589 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1646

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1707 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1817

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1818 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1867

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1868 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1912

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1913 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1945

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2063

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2064 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2161

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2214

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2275 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2326

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2367

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2368 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2421

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2422 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2463

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2464 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2505

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2506 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2556

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2557 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2591

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2645

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2702

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  267 bits (683), Expect = 3e-70
 Identities = 593/2877 (20%), Positives = 1111/2877 (38%), Gaps = 509/2877 (17%)

Query: 23   DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
            DE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLSG  LP E+GR 
Sbjct: 42   DERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 99

Query: 83   MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
              R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL+FQI ++    
Sbjct: 100  --RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI---- 153

Query: 143  PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
                    S  S D                       AK+ LL W Q       G+   +
Sbjct: 154  ------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCDN 186

Query: 203  FGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVD 262
            F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG+ RLLDPEDVD
Sbjct: 187  FTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVD 246

Query: 263  VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF---------- 312
            V +PDEKSI+TYV+      P + +   DG   +E+   +  +   V             
Sbjct: 247  VPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTAA 305

Query: 313  --KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIE 366
              +R     F+E+++   QF    E +L   +  ++  +  YQS +      ++K     
Sbjct: 306  FEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 365

Query: 367  HLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALR 426
            H +      GKL +   L ++   R      +   ++   L    G     L +A+  L+
Sbjct: 366  HPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 424

Query: 427  EEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE- 465
             ++ +    +  + A  ++R L++   ++                Q    ++R +  HE 
Sbjct: 425  SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 484

Query: 466  ------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA 519
                   Y  R   G+  P  Q+         V+  S     ++E   L+Y L  LL   
Sbjct: 485  LVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAWV 536

Query: 520  ESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTA 567
            E              L S   + G    + Q ++ + + IE ++  E      Q+   T 
Sbjct: 537  EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPATR 591

Query: 568  EMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW- 615
              Y    G ++      K +N + A+ R+L    S    + + ++       EEV  +W 
Sbjct: 592  GAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWS 649

Query: 616  DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAGN 665
            DR  N  A  +++      LE  EK + + +NA     R      P       A+    +
Sbjct: 650  DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWS 709

Query: 666  FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFAT 725
            ++++ C   +   LK+     N  + + F +V++ A+                 L     
Sbjct: 710  WMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQE 747

Query: 726  EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEM 785
               +K S     +   ++ L+QD +D ++++         + K A  + +  P+     M
Sbjct: 748  ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 807

Query: 786  FATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEI 837
               +         +++  + K  EC         QL+ P +    ++ S   S   +  +
Sbjct: 808  RGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPSV 858

Query: 838  ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRL 897
              ++    Q +                 ++ +T +E   Q++   VTL + L H D   L
Sbjct: 859  CFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKSL 897

Query: 898  QRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD-- 955
                    +A+QS+ +     +       R +K  EE R  L  +    Q  L +  D  
Sbjct: 898  --------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDAG 948

Query: 956  ---PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWKD 1010
               PE+ L    E+ S             C      L +  +QG QE  R  +   + KD
Sbjct: 949  GFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELKD 995

Query: 1011 --LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHRV 1063
              LQ EA      H L L +D E  R      EC   +  + K   + EG  K +     
Sbjct: 996  IRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV----- 1044

Query: 1064 FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDP 1123
                         RL    E  + LP   P   T          LR+ ++ T  KL +  
Sbjct: 1045 ------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQVR 1082

Query: 1124 DKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG 1173
                 Y  +    S            +  +E QLK  +            K +++++R  
Sbjct: 1083 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1142

Query: 1174 VTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSEV 1224
               +  T   L+  L+   EV           + E ++  + +A+L   ++A++      
Sbjct: 1143 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1202

Query: 1225 EKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLHH 1278
            ++ L   G  ++Y     + L   +  ++  QEQ      A+     E L + Q LL   
Sbjct: 1203 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1262

Query: 1279 QQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELRK 1316
            ++  +++   +R  +Q I   +  E  L                       +   +E   
Sbjct: 1263 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1322

Query: 1317 LESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLS 1376
            L +    L     +  + I  TLR+ E  E   E       Q     ER      L  + 
Sbjct: 1323 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEVE 1370

Query: 1377 SELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKLE 1431
            + LE+ ++ ++       QAE   KE       E+    +     QQQ +SI+E++++L 
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430

Query: 1432 DTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQ 1491
             + E +I+         +      E     I     +L A E      + ++  ++   +
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAE 1487

Query: 1492 EIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTIL 1548
            E E++       +EEA+   + V      + +A++   ++++   E  RE  + L+   L
Sbjct: 1488 EAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA--L 1542

Query: 1549 GHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSA 1608
              L  Q   EE  R+++Q+  E   ++ V ++    + E                 L S 
Sbjct: 1543 EELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQSK 1585

Query: 1609 ITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ---- 1658
              +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E  L  WQ    
Sbjct: 1586 RASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1643

Query: 1659 -----RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFY 1713
                 RL+ E  +    L + EA+    E +  A R    G+ +     Q E+  Q    
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEK 1700

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
             + L    +   +A++ ++  ++   EQ +++ + L + + +      +   + Q+ +  
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760

Query: 1774 LLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKGE 1819
            L      +++ L+       E ++TSE S    +    R ++ A E        E  K +
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820

Query: 1820 LQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVVE 1861
             Q  +   A            KL ++G A       ++ L + +AE+     E   ++ E
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLAE 1875

Query: 1862 RRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALES 1921
                    L E    H   + I  +L Q  +A++S  + +  L+E  L    Q  + + +
Sbjct: 1876 DEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933

Query: 1922 AAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGTK 1969
               S +     KA+  L++G           S EQ     A   QL  E ER +     +
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAE 1991

Query: 1970 QSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDEL 2028
            +    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++L++  +     
Sbjct: 1992 ERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE----- 2045

Query: 2029 NSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM 2088
                        K  Q  +K  AFA  V ++   L+ T    + ++ + +G+        
Sbjct: 2046 ---------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094

Query: 2089 REYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTS 2147
             E +  +  A  +  ++   V       +  E+   A ++ + A  K+  + +      +
Sbjct: 2095 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154

Query: 2148 KGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRD 2207
            + +      K+   ++    K   E T    L    ++E+ +  LR+ L   D   +  D
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLLD 2210

Query: 2208 EIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVNDL 2261
            E          + A   S ++  L     + EEL K +   E +N+AL L +   K N  
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNTQ 2267

Query: 2262 KELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFT 2321
            + L +  E    +    A L    + A  + ++A+   +D   Q    EK + +      
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KMQ 2321

Query: 2322 KVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
             V+E+    A+ E  +     A ++ + +Q++ +     ++   +            +LE
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 2377 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2436
                A    ++  E      S+ QA  +E  ++ F +  +E  E     + A +E     
Sbjct: 2382 MSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLV 2435

Query: 2437 GDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEE 2495
               ++   +  HD + + +++++ + + + + QE + L   L  + + ++Q++       
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------- 2486

Query: 2496 FQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK 2554
                  Q L++ QALQ    SE  S   + R +     ++E+ F  E + +++Q   E++
Sbjct: 2487 ------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQQ 2539

Query: 2555 NEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKE 2614
             +  ++E     L+A+ E     ++R Q  +EEG    QE             L ++ ++
Sbjct: 2540 RQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQQ 2583

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
            + +  ++  +E++ L E LQ +    +A    LA +E    S+    K L   +D L
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2637



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 253  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 312

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 313  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 355

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 356  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 404

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 405  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 462  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 518

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 519  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 575

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 576  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 627

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 628  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 685

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 686  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 743

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 744  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 803

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 804  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 858

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 859  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 918

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 919  RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 978

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 979  GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1033

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1034 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1152 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1272 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1329

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1330 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1385

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1386 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1423

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1468

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1469 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1518

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1519 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1573

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1634 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1674

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1728

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1785

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1838

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1893

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 1894 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2054

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2055 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2112 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2229

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2290 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2401

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2402 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2447

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2448 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2488

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2489 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 551  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 605

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 606  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 661

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 662  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 700

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 701  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 739

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 740  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 779

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 780  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 836

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 837  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 889

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 890  LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 949

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 950  FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1008

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 1009 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1067

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1115

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1116 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1168

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1169 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1228

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1285

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1402

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1403 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1449

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1450 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1498

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1558

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1614

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1735 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1776

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1777 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1829

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1889

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 1890 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1949

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2065

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2232

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2233 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2276

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2277 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2335

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2336 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2452

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2453 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2507

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2508 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2609



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1140 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1186

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1187 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1239 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1297

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1353

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1529

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1710 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1761

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1819

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 2000 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2048

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2109 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2143

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2144 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2252

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2253 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2312 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2367

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2368 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2410

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2460

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2514

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2515 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2570

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2627

Query: 6406 ALLP 6409
              LP
Sbjct: 2628 KTLP 2631



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1148

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1387

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1388 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1444

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1445 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1492

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1493 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1546

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1603

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1840

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1895

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2076 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2235

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2236 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2265

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2326 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2492 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2526

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1152 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1212 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1259

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1260 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1314

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1315 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1367

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1368 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1484 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1594

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1595 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1700

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1701 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1750 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1801

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1862 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 1974 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 2025 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2061

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2119

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2157

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2206

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2207 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2264 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2313

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2314 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2358

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2419 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2472 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2577

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2636

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2637 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2677



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 396  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 452

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 453  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 505

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 506  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 562

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 563  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 617

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 618  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 675

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 676  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 732

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 733  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 792

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 793  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 852

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 853  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 910

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 911  RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 966

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 967  HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1022

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 1023 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1076

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1191

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1312 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1367 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1415

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1416 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1534

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1585

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1633

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1684

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1685 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1728

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1729 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1781 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 1899 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 1951

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 1952 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2054

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2055 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2112 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2217

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2218 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2277 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2323

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2324 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2383 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2441

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2442 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2489

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2490 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2545

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2546 E--QERQRLVA 2554



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 1009 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1062

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1121

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1122 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1181 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1225

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1226 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1266

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1267 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1303

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1304 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1357

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1415

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1416 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1450

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1559

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1678

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1726

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1727 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1769

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1770 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 1889 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2005

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2066 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2117

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2171

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2172 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2218

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2219 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2259

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2308

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2309 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2333

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2334 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2391

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2392 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2433

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2434 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2487

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2488 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2533

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2534 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2591 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2619



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1236

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1296

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1413

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1706

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1707 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1755

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1806

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1807 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1846

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1847 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1893

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 1894 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 1947 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1997

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2051

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2108

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2229 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2286 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2345

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2404

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2405 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2455

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2510

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2565

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2566 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2617 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2668

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2669 S-AEELQRLAQGHTTVDELA 2687



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1129

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1130 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1364

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1484

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1538

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1539 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1592

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1593 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1643

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1644 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1818

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1819 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 1873

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 1874 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 1928

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 1968

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2026

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2027 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2379 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2552

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2553 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2609 HRAALAHSEEVTASQVAATKT 2629



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 867  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 918

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 919  RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 965

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 966  ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1017

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1074

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1075 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1126

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1181

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1240

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1241 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1266

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1267 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1322

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1323 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1367

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1368 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1418

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1419 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1475

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1476 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1519

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1520 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1693

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1735

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1854

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1855 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 1903

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2015

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 2016 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2121

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2169

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2223

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2342

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2397

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2458 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2499

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2560 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1146 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1198

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1199 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1258

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1259 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1318

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1365

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1420

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1601 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1655 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1708

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1709 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1758 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1813

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1814 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 1871

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 1872 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1931

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 1932 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 1985

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 1986 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2039

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2100 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2158

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2159 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2218 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 983  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1030

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1031 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1088

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1147

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1189

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1190 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1245

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1298

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1537

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1538 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1592

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1593 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1650

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1711 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1821

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1822 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1871

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 1872 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1916

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 1917 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1949

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2067

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2068 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2110

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2165

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2166 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2218

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2279 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2330

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2371

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2372 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2425

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2426 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2467

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2468 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2509

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2510 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2560

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2561 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2595

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2596 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2649

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2650 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2706

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2707 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2737


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  267 bits (683), Expect = 3e-70
 Identities = 593/2877 (20%), Positives = 1111/2877 (38%), Gaps = 509/2877 (17%)

Query: 23   DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
            DE++ VQK+TFTKW+N HL K +    + DL+ED++DG  L++LLEVLSG  LP E+GR 
Sbjct: 175  DERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 232

Query: 83   MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
              R H + N+  AL +L  R++KLVNI + DIADG P + LGL+WTIIL+FQI ++    
Sbjct: 233  --RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI---- 286

Query: 143  PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
                    S  S D                       AK+ LL W Q       G+   +
Sbjct: 287  ------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGYQGLRCDN 319

Query: 203  FGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVD 262
            F  SWR G  F+++IH  +P L+D+  V  ++N ENL+ AF++AE +LG+ RLLDPEDVD
Sbjct: 320  FTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVD 379

Query: 263  VDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF---------- 312
            V +PDEKSI+TYV+      P + +   DG   +E+   +  +   V             
Sbjct: 380  VPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQWMRHHTAA 438

Query: 313  --KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIE 366
              +R     F+E+++   QF    E +L   +  ++  +  YQS +      ++K     
Sbjct: 439  FEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGY 498

Query: 367  HLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALR 426
            H +      GKL +   L ++   R      +   ++   L    G     L +A+  L+
Sbjct: 499  HPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 557

Query: 427  EEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKRAF--HE- 465
             ++ +    +  + A  ++R L++   ++                Q    ++R +  HE 
Sbjct: 558  SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 617

Query: 466  ------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA 519
                   Y  R   G+  P  Q+         V+  S     ++E   L+Y L  LL   
Sbjct: 618  LVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-LQDLLAWV 669

Query: 520  ESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTA 567
            E              L S   + G    + Q ++ + + IE ++  E      Q+   T 
Sbjct: 670  EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG-----QLSPATR 724

Query: 568  EMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------EEVISNW- 615
              Y    G ++      K +N + A+ R+L    S    + + ++       EEV  +W 
Sbjct: 725  GAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWS 782

Query: 616  DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHTAMNDAGN 665
            DR  N  A  +++      LE  EK + + +NA     R      P       A+    +
Sbjct: 783  DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWS 842

Query: 666  FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFAT 725
            ++++ C   +   LK+     N  + + F +V++ A+                 L     
Sbjct: 843  WMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ---------------LQKLQE 880

Query: 726  EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEM 785
               +K S     +   ++ L+QD +D ++++         + K A  + +  P+     M
Sbjct: 881  ALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPM 940

Query: 786  FATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEI 837
               +         +++  + K  EC         QL+ P +    ++ S   S   +  +
Sbjct: 941  RGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGSEAAVPSV 991

Query: 838  ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRL 897
              ++    Q +                 ++ +T +E   Q++   VTL + L H D   L
Sbjct: 992  CFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL-HVDMKSL 1030

Query: 898  QRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGD-- 955
                    +A+QS+ +     +       R +K  EE R  L  +    Q  L +  D  
Sbjct: 1031 --------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFLRDSQDAG 1081

Query: 956  ---PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--KLHKQWKD 1010
               PE+ L    E+ S             C      L +  +QG QE  R  +   + KD
Sbjct: 1082 GFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQRCISELKD 1128

Query: 1011 --LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEKIIKEHRV 1063
              LQ EA      H L L +D E  R      EC   +  + K   + EG  K +     
Sbjct: 1129 IRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGKGV----- 1177

Query: 1064 FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDP 1123
                         RL    E  + LP   P   T          LR+ ++ T  KL +  
Sbjct: 1178 ------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTLGKLEQVR 1215

Query: 1124 DKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG 1173
                 Y  +    S            +  +E QLK  +            K +++++R  
Sbjct: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1275

Query: 1174 VTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKALVTLLSEV 1224
               +  T   L+  L+   EV           + E ++  + +A+L   ++A++      
Sbjct: 1276 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1335

Query: 1225 EKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEAQQLLLHH 1278
            ++ L   G  ++Y     + L   +  ++  QEQ      A+     E L + Q LL   
Sbjct: 1336 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEI 1395

Query: 1279 QQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDRGHEELRK 1316
            ++  +++   +R  +Q I   +  E  L                       +   +E   
Sbjct: 1396 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD 1455

Query: 1317 LESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLS 1376
            L +    L     +  + I  TLR+ E  E   E       Q     ER      L  + 
Sbjct: 1456 LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER------LAEVE 1503

Query: 1377 SELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIKEQVKKLE 1431
            + LE+ ++ ++       QAE   KE       E+    +     QQQ +SI+E++++L 
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563

Query: 1432 DTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQ 1491
             + E +I+         +      E     I     +L A E      + ++  ++   +
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAE 1620

Query: 1492 EIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTIL 1548
            E E++       +EEA+   + V      + +A++   ++++   E  RE  + L+   L
Sbjct: 1621 EAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA--L 1675

Query: 1549 GHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSA 1608
              L  Q   EE  R+++Q+  E   ++ V ++    + E                 L S 
Sbjct: 1676 EELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA---------------ELQSK 1718

Query: 1609 ITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLAHWQ---- 1658
              +F+    ++    S  +E  A+ Q  E+  RRA+++  A       E  L  WQ    
Sbjct: 1719 RASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1776

Query: 1659 -----RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFY 1713
                 RL+ E  +    L + EA+    E +  A R    G+ +     Q E+  Q    
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEK 1833

Query: 1714 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1773
             + L    +   +A++ ++  ++   EQ +++ + L + + +      +   + Q+ +  
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893

Query: 1774 LLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-------VESKKGE 1819
            L      +++ L+       E ++TSE S    +    R ++ A E        E  K +
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953

Query: 1820 LQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFEEASQVVE 1861
             Q  +   A            KL ++G A       ++ L + +AE+     E   ++ E
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----ERLRRLAE 2008

Query: 1862 RRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALES 1921
                    L E    H   + I  +L Q  +A++S  + +  L+E  L    Q  + + +
Sbjct: 2009 DEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066

Query: 1922 AAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERIQNLLGTK 1969
               S +     KA+  L++G           S EQ     A   QL  E ER +     +
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR--EAE 2124

Query: 1970 QSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDEL 2028
            +    +LA  ++A + Q++  L+ +E ++ + ++  RL+E   Q   ++L++  +     
Sbjct: 2125 ERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE----- 2178

Query: 2029 NSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM 2088
                        K  Q  +K  AFA  V ++   L+ T    + ++ + +G+        
Sbjct: 2179 ---------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227

Query: 2089 REYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTS 2147
             E +  +  A  +  ++   V       +  E+   A ++ + A  K+  + +      +
Sbjct: 2228 EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287

Query: 2148 KGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRD 2207
            + +      K+   ++    K   E T    L    ++E+ +  LR+ L   D   +  D
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETDHQKNLLD 2343

Query: 2208 EIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEELHSKVNDL 2261
            E          + A   S ++  L     + EEL K +   E +N+AL L +   K N  
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD---KDNTQ 2400

Query: 2262 KELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFT 2321
            + L +  E    +    A L    + A  + ++A+   +D   Q    EK + +      
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLKE---KMQ 2454

Query: 2322 KVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2376
             V+E+    A+ E  +     A ++ + +Q++ +     ++   +            +LE
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 2377 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRT 2436
                A    ++  E      S+ QA  +E  ++ F +  +E  E     + A +E     
Sbjct: 2515 MSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELATQEKVTLV 2568

Query: 2437 GDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEE 2495
               ++   +  HD + + +++++ + + + + QE + L   L  + + ++Q++       
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE------- 2619

Query: 2496 FQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK 2554
                  Q L++ QALQ    SE  S   + R +     ++E+ F  E + +++Q   E++
Sbjct: 2620 ------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQQLREEQQ 2672

Query: 2555 NEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKE 2614
             +  ++E     L+A+ E     ++R Q  +EEG    QE             L ++ ++
Sbjct: 2673 RQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ELQQLEQQ 2716

Query: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL 2671
            + +  ++  +E++ L E LQ +    +A    LA +E    S+    K L   +D L
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNGRDAL 2770



 Score =  125 bits (313), Expect = 2e-27
 Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)

Query: 4717 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4771
            ++I+  V+ L +A+  +   ++G R+      WQ  + L L+ L    H      E+R  
Sbjct: 386  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 445

Query: 4772 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4826
                  S+++E E +  Q             K  E  LPA+E  K     +Y SL G++Q
Sbjct: 446  ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 488

Query: 4827 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4886
               +           + P   PL  EK   ++     E +    +  E + EC  R+V  
Sbjct: 489  AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 537

Query: 4887 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4945
            +  Q E     + L +  A L   V L L    + +   +++   ++  S +R++ N + 
Sbjct: 538  L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594

Query: 4946 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4989
                  H + E+  +      + L++   E++L   +   G    A +  Q TL      
Sbjct: 595  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 651

Query: 4990 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 5048
             E+     RY Q   A   W+E+ Q  +  A  G+D+ S E  L SH     + ++F + 
Sbjct: 652  PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 708

Query: 5049 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5108
            +E   S    L P  +   ++ L      L+L+  ++   S A++    R     H +  
Sbjct: 709  IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 760

Query: 5109 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5168
            A  + +  +N+ E++   F     +++  A  K   + AL+  +    +KI  L+    +
Sbjct: 761  AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 818

Query: 5169 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5228
            L +  + A + T+      +  +W+ +  +    E  L++    +  F++ V++A   + 
Sbjct: 819  LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 876

Query: 5229 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5282
            +LQ+ L    S    A+   L  LL+       +L + +  L  L ++  +++Q      
Sbjct: 877  KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 936

Query: 5283 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5335
            A P  G  P L        E+T  + D C  +     ++ K++          E  + SV
Sbjct: 937  AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 991

Query: 5336 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5388
               V    +        ++AQ + L  L  +     +++      +++  L         
Sbjct: 992  CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 1051

Query: 5389 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5422
             T+ P E   +L   E+     +RD                          Q  ++ +EQ
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1111

Query: 5423 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5482
                     R I +L KD+   L   + +T + ++   D++   E    C  ++ E   A
Sbjct: 1112 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1166

Query: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
             Q  +E  G+    L+ +  K+  L + +   A    S+L      LE+   +  + L+ 
Sbjct: 1167 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224

Query: 5543 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5595
            ++   ++  GT     +      QL+E   +  TL  LE +K    +L A  E  Q    
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284

Query: 5596 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5632
                         E++ Q+  E   E E  R+ +               +R + L+   +
Sbjct: 1285 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344

Query: 5633 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5688
             ++ +      L A L+ A    +     P     +++EQL   Q LL E+E    KV+ 
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404

Query: 5689 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5745
             Q   +  +   +D    L L     +L+  AS  +   +Q    +++Q  V     Y +
Sbjct: 1405 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1462

Query: 5746 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
                  ++++ + E   R  E++ +A     E + +++  E   +K    Q Q+A  +++
Sbjct: 1463 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1518

Query: 5802 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5861
             K    +           EV    E   D   +                         + 
Sbjct: 1519 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1556

Query: 5862 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5921
            EE  +   +SE       R       +   + ++I         RLQ +A          
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1601

Query: 5922 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5981
             E    G E       G+LQ      +   ++K++   EA   +++ QD  +S   +   
Sbjct: 1602 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1651

Query: 5982 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 6041
            +EL      E   + E Q A  QAL  E L LQ E  E +  L +  V  + +   A + 
Sbjct: 1652 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1706

Query: 6042 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6093
            A +S    L ++R S     A  +R L EE     +L ++ E + Q+QA  +R R EA+ 
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766

Query: 6094 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6153
            EL+ W L     L   L   +                   +QK +A +E     E    E
Sbjct: 1767 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1807

Query: 6154 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6210
             +A  + +AE+ A + R L    LE QR L       +GTAQ++   E+  + L A    
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1861

Query: 6211 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6264
            G Q  + L +      ++  ++ Q+++ELE EL    AE + LL S A   EE     S 
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1918

Query: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
            +E S    E      +EL  E  +  A  +   +   L +E + +Q+        E E+V
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1971

Query: 6325 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6381
            L  +   +     L  + ++  ++K A    L  L  ++AF+    +   A+ ++     
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 2026

Query: 6382 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6437
                          D+EERL    A L + +++ L  Q+ L +D     +++ EE+   K
Sbjct: 2027 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068

Query: 6438 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6484
              F +A         E G  R   EDTL           R   L +   +R  + +ER+Q
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128

Query: 6485 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6538
            + L  + +     K     +   K  +   ++L    EQ  A Q++  Q+A     + + 
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2187

Query: 6539 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6597
               E        Q EQ   Q L + Q + D+L     + R    +    + Q ER A Q 
Sbjct: 2188 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244

Query: 6598 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6654
               + E  + K + +++    ++ + Q   +K  KE  Q         +   R  +    
Sbjct: 2245 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302

Query: 6655 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6707
             ++K  +F  + + Q + V +      ++LE      + LDE+ Q       E +RQ   
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2362

Query: 6708 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6758
            VE  + SV +  E   +L  RI             + +  L E   K+ QV ++  RL +
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422

Query: 6759 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6817
            +   +   ++L QL E  L+    ++ K L      ++  TR ++E+  L    + A+++
Sbjct: 2423 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479

Query: 6818 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6877
                 +    + Q+L          LE  ++   + S ++  L      LR+ ++  A  
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2534

Query: 6878 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6937
            R+E    D+Q          + EKLH+ ++       A  E ++ +  +E  IQ+ + + 
Sbjct: 2535 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2580

Query: 6938 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6997
                  +AI E L++ K  K+    K          +LQ+ S+++++ +       EQL 
Sbjct: 2581 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2621

Query: 6998 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 7048
             + ++  + Q  ++EK  LL  E  +E         +++ V   +   E Q+++ +Q  Q
Sbjct: 2622 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680

Query: 7049 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
             R    AS++ A +   + E+ ++ K++E++++EQ
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715



 Score =  123 bits (309), Expect = 7e-27
 Identities = 442/2270 (19%), Positives = 867/2270 (38%), Gaps = 352/2270 (15%)

Query: 2438 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2496
            D   +EA+L   + +  S+ + ++K++ A + EGQ     LS     + ++ + + + ++
Sbjct: 684  DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 738

Query: 2497 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2556
               L       ++L+     L SF     K  +W++E EE     +  +   ++  KK  
Sbjct: 739  AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 794

Query: 2557 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2616
               +   + EL    + + +L   G  L  E H A                  R T E  
Sbjct: 795  YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 833

Query: 2617 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2676
            ++             ALQ+ W W+  +     C E+ L       +  S +++      E
Sbjct: 834  QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 872

Query: 2677 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
            G+++      K ++ALR      +    T+LE L +           AQ   E    Q N
Sbjct: 873  GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 912

Query: 2737 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2795
            +Y    + L +  ++V Q K  HP  P  G      + D+ Q    E   H     +L+ 
Sbjct: 913  EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 969

Query: 2796 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2855
             ++  + K    S  + A   +          A+E + ++E     H   +   H+    
Sbjct: 970  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 1022

Query: 2856 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2902
            LH   + L  W  +  D       S AT + L   + ++ + S E+      R       
Sbjct: 1023 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 1082

Query: 2903 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2962
              PE +           H   Q L++  +Q      + Q C+  L       E   +  V
Sbjct: 1083 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1141

Query: 2963 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3019
             +L   L++  A     +   QQ    E +   + +     + +++L AL +  P    L
Sbjct: 1142 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1200

Query: 3020 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3079
            +S+L         + + S      +K  + +     +G Q  E++L        R  ++ 
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1248

Query: 3080 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3135
            L  A+        +P  + E+  +   +++  +++E  Q   + +  +     E+   L 
Sbjct: 1249 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1301

Query: 3136 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3190
             +   + ++      +V    E W+   +    ++  LE L  Q++ +  SA+P+  WL 
Sbjct: 1302 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1361

Query: 3191 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3249
               +   +  +  L D  A R + ++ Q++LEEI  +  ++   +  A+Q      A K 
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1418

Query: 3250 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3307
            +  ++    +Q   +++  K+ KV S  + ++ E+        EL    +  I  +    
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478

Query: 3308 HPTSDKSVL--DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQS 3365
                ++  L    R  + E L  V+   E Q ++     ++  Q  +      +QQ++Q 
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ- 1535

Query: 3366 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3425
                        +R +     A  +  S Q+ ++Q      S EA +    RQ AE  ++
Sbjct: 1536 ---------EEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKARQ-AEAAER 1582

Query: 3426 TTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT 3485
            + +      + EE+      LE  E +  G       + ELQ L+ R    + + ++A  
Sbjct: 1583 SRL-----RIEEEIRVVRLQLEATERQRGG------AEGELQALRARAEEAEAQKRQAQE 1631

Query: 3486 KSEKLVRLHQEYQRDLKAFEVWLG-----------QEQEKLDQYSVLEGDAHTHETTLRD 3534
            ++E+L R  Q+  +  +  EV L            ++Q  L     L   A   E  LR 
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ 1691

Query: 3535 LQ-----ELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSET 3589
             +     ++QV     Q    + L ++         Q E     SL+++  A      E 
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVAVAQLREEA 1747

Query: 3590 RTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEV- 3648
              +        R  E+  ++++ W   A E +  R + +     K +   + +K  EE  
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807

Query: 3649 --TAYRDEVEEVGARAQEILDESHVNSRMGCQAT--------QLTSRYQALLLQVLEQIK 3698
                 R + EE   R +E+ ++     R   + T        Q   R +A   Q  +Q +
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867

Query: 3699 FLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDME 3758
             LEEE+  L+   ++         +T K  + +  ++ KV   M        EVLL    
Sbjct: 1868 LLEEELARLQREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKA 1909

Query: 3759 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA 3818
            +     +S  EK ++ +    E EA R R E+ +   +L+ L    +++    E+    A
Sbjct: 1910 RAEEESRSTSEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAA 1962

Query: 3819 KEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVL 3867
            ++ ++  + L + +A   E   +  E ++ L EK+A+  +            + L++   
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 2022

Query: 3868 SHEPSVK----SVREKGEALLE----LVQDV-----TLKDKIDQLQSDYQDLCSIGKEHV 3914
             H+  ++     +R+  ++ LE    LV+D       ++++I  L++ ++   +   E  
Sbjct: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE 2082

Query: 3915 FSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLA-------HHK 3967
              L     + ED     ++ E    +        +     + E + + LA         K
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142

Query: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 4027
            A +EE+   + ++   +   +    + A  LQ   ++     LQ  + +++      Q+ 
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHA---FAVQQK 2198

Query: 4028 YQSLEHELQKHVSRQDTLQ-QCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRAL---- 4082
             Q L+  LQ+  S  D L+ + +A   A +   E   Q     A++ +QV+    L    
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258

Query: 4083 QEQARTYLDLLCSMCDLSNASVKTTAKDIQQ---------------------TEQTIEQK 4121
            +EQA+       +   L   + +  A+  Q                       EQT+ QK
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318

Query: 4122 LVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
                Q LT      EE  H K+ L       D++LQ +K   +E     A    SQV++ 
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLL-------DEELQRLKAEATE-----AARQRSQVEE- 2365

Query: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
                  +  SV   +E+++KL  + E+ E++ +         + R  +N     +E+ ++
Sbjct: 2366 ------ELFSVRVQMEELSKLKARIEA-ENRAL---------ILRDKDNTQRFLQEEAEK 2409

Query: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSD-AESTAVHLEALKKLALALQER---KYAIED 4294
             +   +    + V  ++       LA  D A+  A+  + LK+   A+QE    K   E 
Sbjct: 2410 MKQVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2468

Query: 4295 LKDQKQKMIEHLN--LDDKELVKEQTSHLEQRWFQ--LEDLIKRKIQVSV------TNLE 4344
            L+ QK+   E      +DKE + +Q +  E + FQ  LE   +R++++S         + 
Sbjct: 2469 LQQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527

Query: 4345 ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI---CSELEAKQMLL 4401
            E++  Q+R +E  +   +Q   I E L ++      +  L+  L I    S+ +A++  L
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--L 2585

Query: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
            +  I + +R    L   E +++Q    + Q+       L+ + +      LSEK   L  
Sbjct: 2586 REAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLL-- 2640

Query: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
              Q    I+Q + K+       L  D+V+K  +  +  Q   +  + E   L A   E  
Sbjct: 2641 --QRERFIEQEKAKLE-----QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693

Query: 4522 KEVTEQE-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            +   E E     K E L +L++ +   + +L + + RL+E +  L+  +H
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQH 2742



 Score =  119 bits (298), Expect = 1e-25
 Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)

Query: 4902 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4960
            R +AE   P +       +++E+R  Q   E +Q          H E++ +  + +E ++
Sbjct: 1273 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1319

Query: 4961 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 5017
              LE   A L++ D         RQ  L ++  Q + Y +       WL+DA   QE +Q
Sbjct: 1320 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371

Query: 5018 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5071
             A    D ++  E L+         ++    +EE           IK       T K  L
Sbjct: 1372 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430

Query: 5072 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5129
            E   +  +    +   +S  Q  VDL       + +      + I+ +++T +++ E   
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1486

Query: 5130 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5189
            L      E  E+L+E +A +       E     + +A +  K      +  + R      
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546

Query: 5190 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5242
                + R++ ++ +++ + +  E      + + A        E I  ++ +L  +  ++ 
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606

Query: 5243 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5301
             ++ EL  L    +    +  Q Q     LR+Q    +QD +      E  L   + A  
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1662

Query: 5302 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5346
            +      R L   E+++   +  ++ L+  E+         +ET   S +  +Q  +   
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722

Query: 5347 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5397
               T +++  L+E  + +       E    +Q   + A E+ E+ L  + +  +E   L 
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782

Query: 5398 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5435
            LQ  EVA    +     +K KE                V Q +   QEL +Q Q      
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842

Query: 5436 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5493
              +LA +   I  +L+A+T+   Q +  +++L EEL        E  AA QK  E   +L
Sbjct: 1843 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1894

Query: 5494 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5550
             K  A+    +       +++   +E    +L   A    E  E    +    E+AK   
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1952

Query: 5551 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5597
               +A   A++ R +           I   T L+   EI   E EA  E+L+ L     +
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012

Query: 5598 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5649
               ++ +Q A+   + EE    LR+     L+     ++D  +  ++ E E+  L+A+ E
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072

Query: 5650 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5707
            +A A     E+  GR+    + + R    +E+E+ + +  A +  +      E V  SL 
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132

Query: 5708 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5763
                    +EEA+R +  A+++   ++A V +     E+ EQE     QL +    E   
Sbjct: 2133 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2181

Query: 5764 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5823
            K +         A   + +EL Q ++  Q  +  L  + +     A+ A       E E 
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241

Query: 5824 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5883
                 +  + E L                         ++S EE   +   +  A     
Sbjct: 2242 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2276

Query: 5884 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5943
              A  +A+        QA   ++   DA        A Q   +          L      
Sbjct: 2277 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334

Query: 5944 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5999
             +  KN++ E+ + L     EA  ++ + ++ L S+  +ME +  KL    E        
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2385

Query: 6000 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 6047
             AE++AL+    D       E  E    +AEE    S  A  A        E LA Q  L
Sbjct: 2386 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444

Query: 6048 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6105
               AE+M   +M+A     R   E +L  Q +E  QEQA +R + + +++   L      
Sbjct: 2445 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2500

Query: 6106 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6165
                L         EA+      M  E E+  + ++E+S          +A  +++A++ 
Sbjct: 2501 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2543

Query: 6166 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6225
              +   +   L   + A  +K   +Q    ++++SD D     +  ++E +A+      +
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2593

Query: 6226 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
            + +  LQQ+ +L Q  +E+   ++      +E L+Q + A       EK  +L +E  +E
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2647

Query: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
             EK+  E Q+     +  Q+   +Q+  Q  +EQE+++++ S      +    ++ +   
Sbjct: 2648 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2703

Query: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
            + K      L+   +  EE+ ++     R+ + L ++ +    A S   ++V      AT
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2760

Query: 6406 ALLP 6409
              LP
Sbjct: 2761 KTLP 2764



 Score =  111 bits (277), Expect = 4e-23
 Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)

Query: 5357 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5408
            LE+L+   L+   T   + + +  EEQ ++   +   LP    ++ SL+      + +  
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281

Query: 5409 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5464
                +RD+++   +  E+ +    E   ++++  + +  +L + +A        + + + 
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341

Query: 5465 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5512
            LG +L         L A +Q    +  Q+   PLA       +L Q+             
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401

Query: 5513 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
                 R A+  ++ +      L  Y   LE +    +K KV +           LR  Y 
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461

Query: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
               TL  +  +  SE     E+ + L      E+  +++AE+    E+ RQ+ +   Q  
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1520

Query: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5686
              A ++ K+ +   +++Q  + + +      +  + S++E+L   RQ   +E+++   + 
Sbjct: 1521 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1577

Query: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5746
            +A +  +S LRI E++          +RLQ EA+  Q    +    +QA   + E+ E +
Sbjct: 1578 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1625

Query: 5747 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5806
             +  Q+  E   R+++D+     + ++ QA++     +  + +  +E+  +L +  + L 
Sbjct: 1626 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1679

Query: 5807 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5841
            ++A+ A   L   EVE                           AE T  L+  L      
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1736

Query: 5842 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5894
            H +V  +              E   E    E+       +     R  +       S+ Q
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796

Query: 5895 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5951
              A  Q   AER      K        +E  E  LE       G  Q+     + +I   
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856

Query: 5952 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5994
                  E+QR L E            A +++Q+ +  L  +  +ME +    + + E  R
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916

Query: 5995 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 6051
            S   +  +  +A       L +E   L++ LAEE   +    E D A Q A      VLA
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1973

Query: 6052 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6106
            E+++ I    R+K   +  L E++  N++L    +++A QR R E           KA +
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 2028

Query: 6107 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6148
            +  L+  ++  D E +     + D      ++E++++AL              EL +   
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088

Query: 6149 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6179
                E    +K++AE  A + R+L                             K +L E+
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6237
            +R     +   +   + ++ES   L   Q    +   A+  A     QQ++  LQQ  + 
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208

Query: 6238 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6295
            EQ + +Q       A R  E       AE +    E+    S+    E E  K SAE+Q 
Sbjct: 2209 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262

Query: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6352
            + + ++       +++  Q    + Q EQ    +     + +  +K   +   + K+ V 
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322

Query: 6353 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
              L  L    EE   Q      +   L+ +  +     S     VEE LF          
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2368

Query: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6472
                         ++   EE+ K K           +NR +I            L D   
Sbjct: 2369 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2398

Query: 6473 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6528
             QR  Q + E+++Q+      L V     A  + +  + LA    + E+ + E+++A+Q+
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458

Query: 6529 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6587
            A             LK   + LQ ++   QE + +LQ+  +++   +     G  + L  
Sbjct: 2459 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507

Query: 6588 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6647
            + Q +  +   A+ L+    +M+  Q     ++E+ Q+   + +E  + L    + T+  
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564

Query: 6648 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6704
               + +  +Q++   H  E + +A A L+R  ++  +   +L+  S   +   Q++L ++
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624

Query: 6705 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6764
             + ++ S  S       +D L+ R    +  K+ L +    L+Q               D
Sbjct: 2625 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2659

Query: 6765 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6818
              ++  QL E       +M +E  RL   ++   R Q E+ + +   Q    +L      
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719

Query: 6819 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6867
              E   +++  + ++L+++ +   A L  S+EV A     +  L  G   L
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770



 Score =  104 bits (259), Expect = 4e-21
 Identities = 346/1790 (19%), Positives = 679/1790 (37%), Gaps = 285/1790 (15%)

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKD 4015
            L+TI+  +   +   E +   E++L   Q    TL    A     K  +      Q T D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284

Query: 4016 SYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEPSPQPPLSR 4069
            +       AQ + + L     E +++    R+   Q  + W + + Q D+       L R
Sbjct: 1285 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344

Query: 4070 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4129
                 Q++++R   +    +L       D      +  A  +  + Q + ++L Q Q L 
Sbjct: 1345 -----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQLRQEQALL 1392

Query: 4130 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV 4189
               EEI+    ++    + A Q +  +K    EL+L   +  +  V    KK + +  S 
Sbjct: 1393 ---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKKPKVQSGSE 1447

Query: 4190 NTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRTRDYHDCMN 4247
            + I E V+  T       + E+  L  Q++    ++    ++ EE L  Q+  +  + + 
Sbjct: 1448 SVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQRAEERERLA 1500

Query: 4248 VVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDLKDQKQKMI 4303
             VE  LEK       LA + A++ A      K+L   +QE    R+ A  D + QK+ + 
Sbjct: 1501 EVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556

Query: 4304 EHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE------ELNVVQ 4350
            E L    +    E      Q    E+   ++E+ I+  ++Q+  T  +      EL  ++
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616

Query: 4351 SRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA-------KQMLLKS 4403
            +R +E  E  + Q    AE L++    D +Q      + + S ++A       KQ  L++
Sbjct: 1617 ARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674

Query: 4404 L------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4457
            L       ++A+R +    +   + +Q AL  AQ      ++L  +R  +     +EKT 
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-----AEKTA 1727

Query: 4458 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ---NEVTGLW 4514
             L    Q     ++H      RE         ++  +  + A+  L+ +Q   NE   L 
Sbjct: 1728 QLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782

Query: 4515 AQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFK 4568
             Q  E+ ++ +      E++K E   + +      +  +++     QELEK         
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK--------- 1833

Query: 4569 EDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQT 4628
                       Q  +        +    EL    A+ +   +Q    E  L  LQR    
Sbjct: 1834 -----------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882

Query: 4629 ILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS 4688
                  E     L  +L  +  +  V++A    K    +E+    ++    +E       
Sbjct: 1883 ATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRLEAEAGRFR 1934

Query: 4689 ELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDELNQKKEGFR 4741
            EL  +  R+  +  +   +  L+ +D  R        + +++A +GEA     + +   +
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994

Query: 4742 STGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4801
                    +K      L    + +  QR  L E       + E+   QL +   S  E Q
Sbjct: 1995 --------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046

Query: 4802 SKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
              + E+TL    +++         +   A    +  + L R+  + ED     +    E 
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106

Query: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLRRVKAELSG 4909
            AR +  + + E +           E E R+ +S+  + E +R    +L+ + R+KA++  
Sbjct: 2107 ARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157

Query: 4910 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4969
               L    +  QE  R++Q+ QE  Q                    K L + +  H+ A 
Sbjct: 2158 ARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAEEKAHAFA- 2194

Query: 4970 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAE 5029
            + + + ++Q+ L+  Q+ L ++  + +   +  + A +    A+   + A +   VE AE
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQSRRQVEEAE 2252

Query: 5030 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDS 5089
               +S  E      Q  +  E+L               +++ EQ+ A       R ++  
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA-------RRAQAE 2290

Query: 5090 GAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV 5149
             A +   Q   A+   ++K  E+ +      E++L+   L    + H+            
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----------- 2339

Query: 5150 SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDA 5209
               N   E++  L+ +A++  +  +   +   S  +        + R  A+++  IL D 
Sbjct: 2340 ---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396

Query: 5210 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5269
             D    F   +++  E + Q+ ++    S      A L  L E       +L QQ++   
Sbjct: 2397 -DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DLAQQRALAE 2446

Query: 5270 MLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5329
             + ++ +  +Q+ A     E   L Q+    Q++   +QE              D+E + 
Sbjct: 2447 KMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE--------------DKEQMA 2491

Query: 5330 TQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNIEKMAEEQK 5382
             Q+       Q T E      +E+ A+ E L++ + E       A    Q   K AEE  
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551

Query: 5383 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5442
            EK      +  +EL+ Q  +V L   +  Q Q    + E+ +    EL R+ +KL ++  
Sbjct: 2552 EK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604

Query: 5443 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NGQLGKPLAK 5499
              L +LK++    VQ    +++L E      S L E D+ +Q  +F+EQ   +L +    
Sbjct: 2605 --LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 5559
            ++ K  +L ++  RQ +    +  +  + +EE         + + + +            
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---------EEL 2710

Query: 5560 SQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQVAELGRETE 5614
             QL +Q    + LL EE++ +  +L+ + E+    L +   V  ++  + +    GR+  
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDA- 2769

Query: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5664
                     L      A+    F+   +K+ A   Q    L++ E+ RL+
Sbjct: 2770 ---------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2810



 Score =  100 bits (248), Expect = 8e-20
 Identities = 442/2351 (18%), Positives = 887/2351 (37%), Gaps = 357/2351 (15%)

Query: 2183 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2236
            E L+  + +L++   + ++ L+  D     ++   +   VPQ A  +  +LD   +A+ +
Sbjct: 529  ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 585

Query: 2237 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2292
            ++   ++V+     +  + E+++ +V  L E    + T       E +L  K   A   T
Sbjct: 586  IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 638

Query: 2293 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2342
            +VA+ TL+    +    +   +++ D+  W   VEE+       E    L  V       
Sbjct: 639  QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 695

Query: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
            + + + ++  ++ I   + +   L      A  + LGR      K   +     SK +  
Sbjct: 696  RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 750

Query: 2403 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2462
              ESL    + + +E    +L  K   +   D +  +  + AK      ++  +   + K
Sbjct: 751  SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 808

Query: 2463 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2514
            +  +   G  L    H ++  V S Q  +     ++   L+ C      LK+  A     
Sbjct: 809  IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 865

Query: 2515 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
            S++   E Q +KL   +   +  +       L +  Q   ++K ++++ +  L  L    
Sbjct: 866  SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925

Query: 2572 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2615
            +++ +L  R       G                   G E +L      SH  +L  +  +
Sbjct: 926  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985

Query: 2616 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2662
                          +  Q A+   EA  +AL ++W  +      L   +S    +D    
Sbjct: 986  AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 1043

Query: 2663 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2721
            R   +     +K E + +   ++    QA LR S   G    + +L   +E      S S
Sbjct: 1044 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 1099

Query: 2722 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2768
             H Q  L+S+             IS+  D    + QLE        ++  PL  +P  +E
Sbjct: 1100 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1155

Query: 2769 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2828
                +   Q   +E E   + + RL A++ ++    E      T + EL+      +T+ 
Sbjct: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1209

Query: 2829 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2880
            K E++R +  I  + L  +  V   T    + L + +E+L     +     +  AT+  L
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269

Query: 2881 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2932
             K++   ++++     L      A EV +       +  H E       W++        
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1324

Query: 2933 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2978
            W+  + QT   Q  LE L  Q+    +      A L+ A           L    A+ + 
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384

Query: 2979 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS 3037
              Q+  LLE  +   E++ EC    ++ ++A++  E +    K+QL  +   ++     S
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444

Query: 3038 GKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNI 3097
            G  S +I+EY  L    S+       +  Q  +      ++     ++   +  +  + +
Sbjct: 1445 GSES-VIQEYVDLRTHYSE----LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499

Query: 3098 SEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNF 3157
            +EV  +L+K           Q +L    ++ +  +    KE  + +Q +V   +E   + 
Sbjct: 1500 AEVEAALEK-----------QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1548

Query: 3158 HSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK-- 3215
                   +  L+ L+ Q  + E+ A+  Q   ++  ++  E   R+  L  +  E+Q+  
Sbjct: 1549 QQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607

Query: 3216 ----LQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALSNLTKE 3270
                LQ++       E Q  + +E+A++L  + Q  S+  R    +L+S+  A +   +E
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1667

Query: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK 3330
            K   L  +     Q     + L+    +    +         +  L++     EA L  K
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQV---------QVALETAQRSAEAELQSK 1718

Query: 3331 Q----EKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
            +    EK  Q++  +      +     E     QQQ ++             R + + E 
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------------RAREEAER 1766

Query: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLN----ESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
             L +W    +   +     + +    +    E+E+Q  E   +    GKA+         
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE--------- 1817

Query: 3443 SSLLETIEVKGAGMTEHYVTQLEL--QDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
                           E  V Q EL  Q+L+++ +  +  A++ +   ++L+RL  E ++ 
Sbjct: 1818 ---------------EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ- 1861

Query: 3501 LKAFEVWLGQEQEKL--DQYSVLEGDAHTHETTLRDLQ-ELQVHCAEGQALLNSVLHTRE 3557
                    G++Q +L  ++ + L+ +A       ++L+ EL    AE + LL S     E
Sbjct: 1862 --------GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913

Query: 3558 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ-------- 3609
            +       +   + LE+    ++      +  R        + +L E+   +        
Sbjct: 1914 E--SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971

Query: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
            + E L    E    +T  +     KE +  ++++  E+    R  +EE  A+ +  ++E 
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031

Query: 3670 HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFK 3729
                R    +     R + L+   L Q + +EEEI +L+ S    ++     G      +
Sbjct: 2032 LAQLRKASDSE--LERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-----GKAELELE 2084

Query: 3730 NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL-EEGEAERLRK 3788
                + +  DT +  K+   LE   +  +      +  RE  ER  K L  E EA R RK
Sbjct: 2085 LGRIRSNAEDT-LRSKEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142

Query: 3789 EIHDHMEQLKELTSTVRKEHMTLE----KGLHLAKEFSDKCKALTQWIAEYQEILHVPEE 3844
               + +E+LK      R+     E    + L LA+E + K                +  E
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------------RLQAE 2187

Query: 3845 PKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA---LLELVQDVTLKDKIDQLQS 3901
             K   +   A   K + LQQT+   +  +  +R + EA     E  ++  ++ + +  QS
Sbjct: 2188 EKAHAF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244

Query: 3902 DYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQ 3961
              Q      +    S E + +      +  +++ K   Q + R    +       +    
Sbjct: 2245 RRQ--VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302

Query: 3962 QLAHHKAMMEEI----AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSY 4017
            ++  HK   E+     A  E  L  L+++ +       DH +  L +     LQ  K   
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDE----ELQRLK--- 2350

Query: 4018 SAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-----VQPDLEPSPQPPLSRAEA 4072
             A  + A R    +E EL     + + L + +A + A     +  D + + +     AE 
Sbjct: 2351 -AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409

Query: 4073 IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGW 4132
            +KQV      +E AR       S+     A ++  A++    ++ + +K+++ +   Q  
Sbjct: 2410 MKQV-----AEEAAR------LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK--MQAV 2456

Query: 4133 EEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ------ 4186
            +E   LK+E  + LQ   +  Q   RR  E +  +AQ +  + + F + L++++      
Sbjct: 2457 QEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515

Query: 4187 -ASVNTIIEKVNKLTKKEESPE------HKEINHLNDQW--LDLCRQSNNLCLQREEDLQ 4237
             A    +  +V ++++ +   E       K+   + ++    +L  Q     +Q  E +Q
Sbjct: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-IQ 2574

Query: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
            R +  HD   + E            +A  + E   +  EA K L L  +E +   ++   
Sbjct: 2575 RQQSDHDAERLREA-----------IAELEREKEKLQQEA-KLLQLKSEEMQTVQQEQLL 2622

Query: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
            Q+ + ++   L +K+ + ++   +EQ   +LE L     Q  V   ++L   Q R Q+ M
Sbjct: 2623 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL----FQDEVAKAQQLREEQQRQQQQM 2678

Query: 4358 EWAEEQQPNIA 4368
            E  +E+Q  +A
Sbjct: 2679 E--QERQRLVA 2687



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 339/1895 (17%), Positives = 734/1895 (38%), Gaps = 322/1895 (16%)

Query: 1799 HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ 1858
            H++ L   K+ A E   +  E Q  Q  +  LG     + +  L  +AE    L  E S 
Sbjct: 1142 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLG-----KGVARLSAEAEKVLAL-PEPSP 1195

Query: 1859 VVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKA 1918
                 +  L      L+   SLS I  +  +T+       +   +++     + L+ A+A
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH-EEQLKEAQA 1254

Query: 1919 LESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG--EV-ERIQNLLGTKQSEADA 1975
            + +    L+   +  +  L+  +  Q+ +  A  D+L G  EV ER+Q   G +  E + 
Sbjct: 1255 VPATLPELEATKASLK-KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313

Query: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
                   ++++  +LL+  + +  +TD   +++   + L ++LR + +  D L +     
Sbjct: 1314 -------WRERVAQLLERWQAVLAQTD---VRQRELEQLGRQLRYYRESADPLGA----- 1358

Query: 2036 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK 2095
             WL+D  ++  Q+ +   P  D +  R ++  +                  L+ E +   
Sbjct: 1359 -WLQDARRR--QEQIQAMPLADSQAVREQLRQEQA----------------LLEEIERHG 1399

Query: 2096 SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSE 2155
              V +    A   I     IKD E                      L  + ++ + + S 
Sbjct: 1400 EKVEECQRFAKQYI---NAIKDYE--------------------LQLVTYKAQLEPVASP 1436

Query: 2156 LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNN 2215
             KK        V++  ES + +++D+     E        +    + L   +E E  +  
Sbjct: 1437 AKK------PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1490

Query: 2216 CVPQMAENISNLDNHLRAEELLKEFESEVKNKALR-LEELHSKVNDLKELTKNLETPPDL 2274
               +  E ++ ++  L  +  L E  ++ K +A R  +EL  ++ +  E+ +  E   D 
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--EVVRREEAAVDA 1548

Query: 2275 QFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNE 2334
            Q  +  + ++L+  ++ +E       +  A++ Q E                    A+  
Sbjct: 1549 QQQKRSIQEELQQLRQSSEA------EIQAKARQAE-------------------AAERS 1583

Query: 2335 TCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAEL---------ESLGRAMTGL 2385
                 ++++ ++ +L++ +      +  L +L  +   AE          E L R +   
Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 2386 I-KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEA 2444
              +K +A  +L S+ +A  + + EK    ++Q  +E  L A+ A +         ++ +A
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQ--RALQALEELRLQAEEAER---------RLRQA 1692

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ---ITKANEEFQAFLK 2501
            ++   + +  ++   Q   +A  Q  +  +A  + Q+  S+QE+   + +  EE +   +
Sbjct: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752

Query: 2502 QCLKDKQALQDCASELGSFE---DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2558
            Q  + ++A ++   EL  ++   ++  +L L   E+ ++ +       KQ   E + E  
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK-EEAEREAR 1811

Query: 2559 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRS 2618
            +      + +  RE  ++  ++ + L+E   G  Q      Q L + Q L+R+  E    
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAE---GTAQ------QRLAAEQELIRLRAET--- 1859

Query: 2619 CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE 2678
             +   Q+ + LEE L  +         R A A +    +  LE  L+++      + E E
Sbjct: 1860 -EQGEQQRQLLEEELARL--------QREAAAATQ--KRQELEAELAKV------RAEME 1902

Query: 2679 VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
            V L  +  + E+  RS++++ ++ ++ +    +E+  +       A+           D 
Sbjct: 1903 VLL-ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961

Query: 2739 VERKNQLE----QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2794
              ++ + E    + + ++ +      + +  LKEK    + L+ +  +     R L    
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021

Query: 2795 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTD 2854
            A+ +   E+   +  +  +  EL+ Q   +    +++ +  EEI+     +  A     +
Sbjct: 2022 AQHKADIEERLAQ-LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080

Query: 2855 W------LHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
                   + S  E+  R  + +   +A Q++L+  +E    R     R+ +  +   E  
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAEEEAA 2138

Query: 2909 QNTTASGCELMHTEM---QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2965
            +   A+  E+   +    +A R   +  ++S  Q Q   E    ++   E+  +  V Q 
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198

Query: 2966 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNE 3025
            EQ L+Q      T  Q+ ++L+    + E        +E  +A  +AE      + Q+ E
Sbjct: 2199 EQELQQ------TLQQEQSVLDQLRGEAEAAR--RAAEEAEEARVQAEREAAQSRRQVEE 2250

Query: 3026 LCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKI 3085
              R  +     +   +        L  +A +    + Q  Q   R      Q+   +A++
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR------QKQAADAEM 2304

Query: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQA 3145
               K F   Q + + +   Q++     + E   H+ N++             E+ + ++A
Sbjct: 2305 EKHKKF-AEQTLRQKAQVEQELTTLRLQLEETDHQKNLL------------DEELQRLKA 2351

Query: 3146 KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYD 3205
            + T A            Q E  L ++++QM++           LSK +  + E+ NR   
Sbjct: 2352 EATEAARQRS-------QVEEELFSVRVQMEE-----------LSKLKARI-EAENRALI 2392

Query: 3206 LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALS 3265
            L  K   Q+ LQ   E++     +  RL   AQ+             R+ QL+ + LA  
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA-----------ARLRQLAEEDLAQQ 2441

Query: 3266 NLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3325
                EK+                +KE                     ++V ++  LK EA
Sbjct: 2442 RALAEKM----------------LKEKM-------------------QAVQEATRLKAEA 2466

Query: 3326 LLSVKQEKEI---QMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS 3382
             L ++Q+KE+   Q + +    E + Q  + E     Q+ L++ +     + +   R K 
Sbjct: 2467 EL-LQQQKELAQEQARRLQEDKEQMAQQLAEE-TQGFQRTLEAERQRQLEMSAEAERLKL 2524

Query: 3383 QLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSY 3442
            +              V + S      E +     +Q  E+ +K   L + +L  +E ++ 
Sbjct: 2525 R--------------VAEMSRAQARAEEDAQRFRKQAEEIGEK---LHRTELATQEKVT- 2566

Query: 3443 SSLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3500
              L++T+E++    ++H   +L   + +L+     +Q+ AK    KSE++  + QE    
Sbjct: 2567 --LVQTLEIQRQ-QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ--- 2620

Query: 3501 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVI 3560
                   L QE + L Q  + E D+        + ++ ++     Q   + V   ++   
Sbjct: 2621 -------LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE----QLFQDEVAKAQQ--- 2666

Query: 3561 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3620
               + + + R  + + Q+ Q     + E R + +     +R  +++ QQ+++  +  EE 
Sbjct: 2667 ---LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723

Query: 3621 VSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
            ++     + N+  +E QL  +++ H    A+ +EV
Sbjct: 2724 LA-----EENQRLRE-QLQLLEEQHRAALAHSEEV 2752



 Score = 85.5 bits (210), Expect = 2e-15
 Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)

Query: 579  EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 638
            E E   + + +   +W+ +  +    +  LE++      Y  +   L AWL+DA +   Q
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1369

Query: 639  SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 689
             +       + +   ++Q  A+    +     +E C           +D + QL+    +
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1429

Query: 690  WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 746
               +    K+       + + +EY D       L+   ++  K +SE L       +L  
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489

Query: 747  QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 804
            Q   +  +R+  ++A  + +     AH   K   + E KE+     +++E++ + +E   
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1546

Query: 805  PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 842
                + + +   L++L            +Q  +   S  +I E I V+            
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606

Query: 843  -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 883
                          EA++     Q+  E L  Q   E+ +K    +E  S+     +   
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666

Query: 884  TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 935
                 L+  ++ RLQ + A+  +  Q+ V++    +  +ET  R  +         F E 
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 936  RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 992
             A+LE+ L+   +A   L E+ +     +   E   +  +R L  +    +E   +  + 
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785

Query: 993  EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1050
            E+   Q+  A  +  KQ ++ + EA       +    + + +   E    EL+++ +L  
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1839

Query: 1051 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1110
                +++  E  +    +      E++ QL+EE   +L  R+    T         + R 
Sbjct: 1840 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1888

Query: 1111 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1170
             +++   K+  + +      +R  E S   ST+E   + ++ EA      G  +   EE 
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1939

Query: 1171 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1230
                           +RL+ L E +       + D   + + + + L   L+ +      
Sbjct: 1940 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1979

Query: 1231 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1290
             G+  + K   + +L+E     KE + +  + L  +  F+ ++L        ++ +  K 
Sbjct: 1980 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 2026

Query: 1291 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1350
            D+++++AQ ++           EL + +  ++   R R + E  I      +E+    K 
Sbjct: 2027 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079

Query: 1351 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1409
             +   L +  S+ E        ++L S+ EQ +  + R   +A + E   +EA E +   
Sbjct: 2080 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 2130

Query: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
               ++   +Q K+  E+V++L+  +EE  +  E  + +      +   L +     +K L
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2184

Query: 1470 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1526
             A E + + A+  +  +++ T+Q+ +S L  + G  E A+  A+     E AR++A  + 
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2241

Query: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1578
             Q RR  EE     Q  E         Q   E        E  R+ Q   +    K A  
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301

Query: 1579 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1634
             ++        + L++   + Q L +L   +            ++    +   EAA  + 
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361

Query: 1635 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1686
            Q E+ L   + +   L  L A   R+E E  + +         +L+    K      + +
Sbjct: 2362 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418

Query: 1687 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1744
               V  +   +L Q  + ++  Q +   K+L+ K      A+  K + ++++   E   E
Sbjct: 2419 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478

Query: 1745 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1796
            + R L         Q+  +   F +++ AE Q+  E+    +  +KL ++E+      + 
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2537

Query: 1797 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1856
             D Q    R +  A E+  K    +     LA    +   + L + + +++   +   EA
Sbjct: 2538 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2588

Query: 1857 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1916
               +ER +  L   A+ LQ  +     ++Q  Q ++ T ++   +S L EKD    LQ  
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2643

Query: 1917 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1972
            + +E     L+ +    ++KAQ  L+     Q+        +L   +E  +     +Q E
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2698

Query: 1973 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2032
            A+           +K+E L+ +E  ++R  +E L     Q L+++L++  +      +H 
Sbjct: 2699 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749

Query: 2033 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2085
             E+      A Q+A        +D    P  + E    E ++D  +R +   + Q  G++
Sbjct: 2750 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2801

Query: 2086 DLMREYQNLKSAVSKVLENA 2105
                E Q L    + V E A
Sbjct: 2802 S-AEELQRLAQGHTTVDELA 2820



 Score = 84.0 bits (206), Expect = 6e-15
 Identities = 301/1641 (18%), Positives = 631/1641 (38%), Gaps = 222/1641 (13%)

Query: 3781 GEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILH 3840
            G+ E++R     ++E+LK ++  +R      E+ L   +E   + +A+   + E      
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRAHEEQLKEAQAVPATLPEL----- 1262

Query: 3841 VPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL-----VQDVTLKDK 3895
              E  K  L + +AQ    ++ Q T  +    ++  +E GE L +      V+    +++
Sbjct: 1263 --EATKASLKKLRAQA---EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317

Query: 3896 IDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSS 3955
            + QL   +Q + +        LE   +    Y      +  WL     R      +  + 
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377

Query: 3956 LETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH------LQAKLK------ 4003
             + + +QL   +A++EEI    +++   Q      I    D+       +A+L+      
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1437

Query: 4004 ---------QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA---- 4050
                     ++V       +  YS + +   +  + +   L++    +   +Q +A    
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497

Query: 4051 WLSAVQPDLEPSPQ----PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKT 4106
             L+ V+  LE   Q       ++A+A ++ K  +   ++     +           S++ 
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557

Query: 4107 TAKDIQQ-TEQTIEQKLVQAQNLTQG----WEEIKHLKSELWIYLQD---ADQQLQNMKR 4158
              + ++Q +E  I+ K  QA+   +      EEI+ ++ +L    +    A+ +LQ ++ 
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1617

Query: 4159 RHSELEL------NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE-- 4210
            R  E E         A+ +  QV+D  +  + +QA V    E  +++  + E+   K+  
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAEV----ELASRVKAEAEAAREKQRA 1671

Query: 4211 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
            +  L +  L        L   R+ +++R R     +   +   E    E  +   S AE 
Sbjct: 1672 LQALEELRLQAEEAERRL---RQAEVERARQVQVALETAQRSAE---AELQSKRASFAEK 1725

Query: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRW-FQLE 4329
            TA       +L  +LQE   A+  L+++ ++  +     + E  +E+     +RW  +  
Sbjct: 1726 TA-------QLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERWQLKAN 1776

Query: 4330 DLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLA 4389
            + ++ ++Q      ++ ++ Q+  ++  E AE +     +A +Q+          ++   
Sbjct: 1777 EALRLRLQAEEV-AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835

Query: 4390 ICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4449
              +E  A+Q L         R   + G  +RQ++++ L+  Q      +    +    L 
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895

Query: 4450 KALSEKTQFLMAVFQATSQIQQHERKI---------MFREHICLLPDDVSKQVKTCKSAQ 4500
            K  +E    L +  +A  + +    K           FRE    L ++ ++     + A+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE----LAEEAARLRALAEEAK 1951

Query: 4501 ASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKC---SHRLQEL 4557
               +  + +     A+   ++      EK   +G+   L++  +  L++    + RL+ L
Sbjct: 1952 RQRQLAEEDAARQRAEAERVL-----AEKLAAIGEATRLKTEAEIALKEKEAENERLRRL 2006

Query: 4558 -EKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYE 4616
             E     R+  +E    A H   +ADI            SEL  Q    ++ L Q  + E
Sbjct: 2007 AEDEAFQRRRLEE--QAAQH---KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE 2061

Query: 4617 NLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4676
              +L L+ + +       E++      + NA                    E  L  KE 
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNA--------------------EDTLRSKEQ 2101

Query: 4677 ASLIELTTQSLSELEAQFLRMS--KVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
            A L     + L+  E +  R +  +V   LA EE  + Q   +A L+EV  L   V+E  
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALEEVERLKAKVEEAR 2159

Query: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLL------EDTTSAYQEHEKMCQ 4788
            + +E         +  + L L     + + Q E++          ++     Q+ + +  
Sbjct: 2160 RLRERAEQ-----ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214

Query: 4789 QLERQLKSVKEEQSKVNEETLPAEEKL---KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4845
            QL  + ++ +    +  E  + AE +    +     A  L+ S     +     +  A  
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274

Query: 4846 LDPLAYEKARHQIQSWQGELKLLTSA---------IGETVTECESRMVQSIDF------Q 4890
            L   A ++A  + Q+ Q  L+   +A           E     ++++ Q +        +
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334

Query: 4891 TEMSRSL--DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRI---MNAL 4944
            T+  ++L  + L+R+KAE +           ++EE+  +++  EE+     RI     AL
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391

Query: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQ-------CQR 4997
              ++K+   +  +  +  ++    E + L    QEA R RQ    ++  Q        + 
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451

Query: 4998 YYQVFQAAN------DWLEDAQELLQLAGNGL--DVESAEENLKSHMEFF--------ST 5041
              Q  Q A       + L+  +EL Q     L  D E   + L    + F          
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511

Query: 5042 EDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGA---QVDLLQR 5098
            + +  +  E L   VA +    +   +ED ++     E   +++ R   A   +V L+Q 
Sbjct: 2512 QLEMSAEAERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570

Query: 5099 CTAQW----HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSH----EAEEKLSEHKAL-- 5148
               Q     HD ++ RE + EL  + EK   E  LL+  S      + E+ L E +AL  
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630

Query: 5149 --VSVVNSFHEKIVALEEKASQLEKTGND-ASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
              +S  +S  ++   +E++ ++LE+   D  +KA   R      ++  + + + Q+++++
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE-----EQQRQQQQMEQERQRL 2685

Query: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
            +    +       +  +A E + + Q++L     ++  + ELL          L+L ++Q
Sbjct: 2686 VASMEEA----RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741

Query: 5266 SALGMLRQQTLSMLQDGAAPT 5286
                +   + ++  Q  A  T
Sbjct: 2742 HRAALAHSEEVTASQVAATKT 2762



 Score = 72.8 bits (177), Expect = 1e-11
 Identities = 375/1971 (19%), Positives = 750/1971 (38%), Gaps = 299/1971 (15%)

Query: 6657 QKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES-SIPSV 6715
            Q+  +  T L AQ  A++   H+  V+++ +L  W       Q L R ++++ S S+ + 
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-AW-------QSLRRDVQLIRSWSLATF 1051

Query: 6716 GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGEC 6775
              ++  E R        Q L S    YQ  L    D G          D      + G C
Sbjct: 1052 RTLKPEEQR--------QALHSLELHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSC 1098

Query: 6776 WLSNTNKMSKELHRLETILKHWTRYQ---SESADLIHWLQSAKDRLEFWTQQSVTVPQEL 6832
                ++   + L  LE   +  +R Q   SE  D+   L++ + R    T   + +P + 
Sbjct: 1099 ----SHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETR----TVHRLRLPLDK 1150

Query: 6833 EMVRDHLNAFLEFSK---EVDAQSSLKSSVLSTGNQLLRLKKVDTA--TLRSELSRIDSQ 6887
            E  R+      E  K   EV+      + + +   ++L L +   A  TLRSEL      
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT--- 1207

Query: 6888 WTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIH 6947
                L  +  V+  L  + ++KL +   IS V+      E V++  E+ +K +    A  
Sbjct: 1208 ----LGKLEQVRS-LSAIYLEKLKT---ISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1259

Query: 6948 EYLQKYKG----FKIDINCKQLTVDFVNQSVL-----------QISSQDVESKRSDKTDF 6992
              L+  K      +     +Q T D +   +            +   +DVE +R     +
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER-----W 1314

Query: 6993 AEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG 7052
             E++  + + WQ +      + + LE L      Y  +   L  W +   +R +Q   + 
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM- 1373

Query: 7053 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 7112
                    L D Q + + ++ ++  +E+IE++G                           
Sbjct: 1374 -------PLADSQAVREQLRQEQALLEEIERHG--------------------------- 1399

Query: 7113 NLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDN 7172
                 V + +   K  ++    +++      + L        + ++ +GS   +Q  VD 
Sbjct: 1400 ---EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVD- 1455

Query: 7173 LQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQ 7232
            L+    +L           ++T+Q +K     ++ETL    +E  +      EE  E+L 
Sbjct: 1456 LRTHYSELT----------TLTSQYIKF----ISETLRRMEEEERLAEQQRAEE-RERLA 1500

Query: 7233 SSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKG 7292
              +A L+   + +  ++  A    Q E    EL +    + +  +E A       D  + 
Sbjct: 1501 EVEAALE---KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV------DAQQQ 1551

Query: 7293 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVL 7352
              ++++ L  L +  E  + Q  A  A A +  +L + + +  +   L  + T  Q G  
Sbjct: 1552 KRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQL--EATERQRGGA 1608

Query: 7353 DYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDR 7412
            + E     L+AL A   EAE           +     QE  E L+ Q+   S      + 
Sbjct: 1609 EGE-----LQALRARAEEAE-----------AQKRQAQEEAERLRRQVQDESQRKRQAEV 1652

Query: 7413 LNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQH----QTFLEKCETW 7468
              EL  R+    +  +  Q   +    +  Q  E   +L+   ++     Q  LE  +  
Sbjct: 1653 --ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710

Query: 7469 MEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQAEMFSRQQI-LHSIIIDGQRLLEQ 7524
             E  +Q+++    E +   +  L+++    A    +AE  ++QQ        + +R LE+
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 7525 GQVDDRDEFNLKLTL--LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEV 7582
             Q+   +   L+L    ++ Q       A++++   + + R+  +  E A + R    E+
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR----EL 1826

Query: 7583 SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
            +   +     +     Q R   ++    E + LR +       E G+Q            
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQ----ELIRLRAE------TEQGEQ--------QRQL 1868

Query: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP- 7701
            L+ ELA +Q +  +A+ + +E + +LA +  + E      A + E+ R+  +K  Q L  
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928

Query: 7702 --DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7759
                  EL  E  R + L            + +  +   +  + A+ ++ + E   L + 
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL-KT 1987

Query: 7760 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7819
            + E    +     +++  RL E   F  +  E        E       DI  EE + +L+
Sbjct: 1988 EAEIALKEKEAENERL-RRLAEDEAFQRRRLE--------EQAAQHKADI--EERLAQLR 2036

Query: 7820 KDYQEEI----AIAQENKIQLQQMGERLA--KASHESKAS---EIEYKLGKVNDRWQHLL 7870
            K    E+     + ++   Q +Q+ E +   KAS E  A+   E+E +LG++    +  L
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096

Query: 7871 ------DLIAARVKKL-----KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                  +L AAR ++L     +    A +++ K++++        E E A+         
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--------EEEAARQRKAALEEV 2148

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRR 7979
            E ++ K+ E + L+   E+ S   A  L L +            A   ++QQ  + L + 
Sbjct: 2149 ERLKAKVEEARRLRERAEQES---ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 7980 WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEEL 8039
             +   ++  + R + E   R  ++        E+    +ER AA             E L
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEA-------EEARVQAEREAAQSRRQ----VEEAERL 2254

Query: 8040 KKFEAFQRQVH-ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
            K+    Q Q   +     E + K+  + A         +L+Q            ++   +
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ------------KQAADA 2302

Query: 8099 ILRRLKHFIGQ--REEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEI 8156
             + + K F  Q  R++ +  ++     LT + LQL   +H     +  ++++LKA   E 
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQE-----LTTLRLQLEETDHQKNL-LDEELQRLKAEATEA 2356

Query: 8157 SLNHNKIEQ----IIAQGEQLIEKSEPLDA---AIIEEELDELRRYCQEVFGRVERYHKK 8209
            +   +++E+    +  Q E+L +    ++A   A+I  + D  +R+ QE   ++++  ++
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416

Query: 8210 LIRLPLPDDE----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
              RL +   E      L++ +L  + + A   L    ++       +  + L L   + L
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL-LQQQKEL 2475

Query: 8266 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8325
              E++ R             +      R LE+   R L    E   + +   LR A  +S
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----EMSAEAERLKLRVAE-MS 2530

Query: 8326 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
               +  E   ++  K  ++   ++ +TE   + K      L+   +           +I 
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590

Query: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
             ++R + KL++E + L     L S E QT         +Q + L +E +  Q     Q F
Sbjct: 2591 ELEREKEKLQQEAKLL----QLKSEEMQT---------VQQEQLLQETQALQ-----QSF 2632

Query: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
             S+ +S+       E+E  +L++L      +  +L+ ++ ++ Q+    R+ ++ S+   
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692

Query: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH 8556
                 +A+    R  Q+ L Q+  +  +   LL E    L++ L   +  H
Sbjct: 2693 RRRQHEAEEGVRRK-QEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742



 Score = 66.6 bits (161), Expect = 1e-09
 Identities = 223/1175 (18%), Positives = 447/1175 (38%), Gaps = 117/1175 (9%)

Query: 7493 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7550
            QQ   +  + E+   Q++       G+RL ++ G+ D + + +  ++  L  +WQ V+ +
Sbjct: 1279 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331

Query: 7551 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7603
               R+  ++   RQ + YRE A+ L  WL        ++  +P++   +V   L+Q + L
Sbjct: 1332 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1391

Query: 7604 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7659
             +E++   EKV    R    YI  ++  +  L++  +  E  A  A+  ++Q   +S   
Sbjct: 1392 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1451

Query: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7719
               + +   + L     +  K I+++L ++               EE  AEQ R +E E 
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1498

Query: 7720 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7777
                      Q  L +    A   A+      E  EL QR  EE+    + ++  QQ   
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1553

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7835
             + E      ++ E        +++ ++   + IEE I   +L+ +  E      E ++Q
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7885
              +     A+A       E E    +V D  Q        +A+RVK       + +  L 
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673

Query: 7886 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7936
            A+++L          L   E E A+ +             E+Q K      +  +L+R +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733

Query: 7937 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7996
            ++    VA +    E            AE +  ++       RW+     ++  RL+ EE
Sbjct: 1734 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787

Query: 7997 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 8053
              +  QK L   +   + E+  + + R       +     +A++EL+K    QRQ+ E  
Sbjct: 1788 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1841

Query: 8054 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8113
             Q        +RLA E        L+    +G Q+   L++ +  + R       +R+E 
Sbjct: 1842 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890

Query: 8114 ETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 8173
            E     +     EM++ L +     E       K  +  + E      ++ +  A+   L
Sbjct: 1891 EAELAKV---RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG-RFRELAEEAARLRAL 1946

Query: 8174 IEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSA 8233
             E+++     + EE+    R   + V         +  RL   + E  L ++E E E   
Sbjct: 1947 AEEAK-RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLR 2004

Query: 8234 ALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD--- 8290
             L++     R      + Q  +++   LAQ  ++  S  +    +    L      +   
Sbjct: 2005 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 2064

Query: 8291 --LSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
              L    E A +     E E G  + + +  LR     S + + LE+  RQ   A ++ R
Sbjct: 2065 LALKASFEKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELEA-ARQRQLAAEEER 2118

Query: 8347 FQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVN 8406
             + ++ E  ++       E     K  ++ +    + ++  +RL  + ++E         
Sbjct: 2119 -RRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----Q 2172

Query: 8407 LHSTETQTAGVIDRWELLQAQAL-SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
            L   +      +   E   A A+  KE  ++Q LQ+ Q     L           EE E+
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232

Query: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF-TQADSKESRDLQDRL 8524
              R++   +      Q+++ + L+++ + +          + +   +A+ + +R  Q   
Sbjct: 2233 -ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQ 2291

Query: 8525 SQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD 8584
            + +  +     + +E+ +   +  L Q     +    L L LE  D +KN +      L 
Sbjct: 2292 AALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350

Query: 8585 AEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
            AE   +  +Q  Q++ EL   ++++  L  +  ++
Sbjct: 2351 AE-ATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384



 Score = 61.2 bits (147), Expect = 4e-08
 Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)

Query: 6120 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
            E++   C + L +I  ++ A    +VH   L L+     K+ A + A ++        E 
Sbjct: 1116 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1163

Query: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6238
            Q+A  + +   +G A+   E++  L   + SP      ++   T  +  Q  ++    + 
Sbjct: 1164 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1221

Query: 6239 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6296
             E  +  SL+       EE+L  H     E        P++ + +  ++  ++ AE Q +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1280

Query: 6297 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6355
              +++L  E    Q++ + + ++  E+                  DV  +  +  V  LL
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1322

Query: 6356 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6412
            +     ++ V +Q+   +R+   L ++L    +       WL D   R     A+   ++
Sbjct: 1323 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1378

Query: 6413 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6469
            +     L  ++ L ++I+   E++++ +    Q         + I+D    L+   + L+
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1431

Query: 6470 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6518
             V +  +  +++   + ++    DL+  ++ L    ++YI         +++   + EQ 
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491

Query: 6519 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6562
             AE+ E + + E  L+                E +A  ++ + + + ++ E+ ++    +
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1551

Query: 6563 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6622
             + + +EL  +  S  + +          ER+   + + +   + ++   ++    ++ E
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611

Query: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6682
            +Q L  + +E            E L R++   + Q++ Q   EL ++  A  + A ++  
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1670

Query: 6683 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6742
             L+ + E     +E ++ L RQ EV  +    V L  E   R  +     Q  ++S  E 
Sbjct: 1671 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1725

Query: 6743 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6802
              +L + L + + + ++    + E +  Q  E   +   +  +EL R +       R + 
Sbjct: 1726 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1783

Query: 6803 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
            ++ ++      A+   E   +++    +     E + VR    A  E  K+         
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843

Query: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
              L+   +L+RL+  +T     +   ++ +   L     A  +K  +L+ +    R  + 
Sbjct: 1844 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902

Query: 6918 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6972
             +++  +  E    +  +K +  ++   G ++ + E   + +    +   ++        
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1954

Query: 6973 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
               Q++ +D   +R++ +   AE+L A+ ++ ++       K +    L E  +E E   
Sbjct: 1955 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 2004

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7090
            +         E    Q+ R+ +QA+   A  D ++ L  L KA + E+E+  Q GL    
Sbjct: 2005 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 2049

Query: 7091 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7150
                     V  TLR+  Q                  V ++  + K +F+K  +   E  
Sbjct: 2050 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 2082

Query: 7151 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7202
              L R R        S E  +++    + L  + E++ R     +QK  +   +  ++  
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142

Query: 7203 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7260
              + E   L   ++E         +E A QLQ ++   Q  +R +   K  A  VQQ+E 
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2200

Query: 7261 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7320
               + L+                Q   D L+G     ++     E  E+ + Q +  AA 
Sbjct: 2201 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2243

Query: 7321 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
            + +  + +      A EQA  + Q    A     E   K  E   A   +AE+    Q  
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2298

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7439
            +  +++   ++  E+   Q  +       L  +L E  ++  L D+E++R++        
Sbjct: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2351

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7499
             +++   + S+++  L   +  +E+       +    + L +    N Q  L+++     
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411

Query: 7500 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7559
              AE  +R  +      +  RL +  + D   +  L   +L  + Q V     Q    + 
Sbjct: 2412 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2463

Query: 7560 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7619
            ++    Q+ +E+A++  + L E                Q A+ L +E Q  ++       
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2504

Query: 7620 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7679
               L  E  +QL +SA++       AE++  Q + +  + R  +Q +++   L    + E
Sbjct: 2505 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2558

Query: 7680 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
                + +  ++T + +  QS  DH     AE++R            + + +L   K+ L 
Sbjct: 2559 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2600

Query: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
                A  + + +E ++ +Q+  E+L  +    +Q            SEK+      L Q 
Sbjct: 2601 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2642

Query: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7859
            E          IE+   KL++ +Q+E+A AQ+ + + Q+  +++ +      AS  E + 
Sbjct: 2643 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2693

Query: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7919
                 R QH  +     V++ +E L   QQL++        LA                +
Sbjct: 2694 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2728

Query: 7920 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7975
            + ++ +L   +E  R    HS  V AS +   + L +  DA    A +AE +       +
Sbjct: 2729 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2782

Query: 7976 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 8031
             D   R + A  ++    L  EE  RL Q    +D+ +R ED     +  +   S +G++
Sbjct: 2783 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2839

Query: 8032 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
                 E+L  + A QRQ+    T L L+  Q
Sbjct: 2840 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2870


>gi|19923599 calmin [Homo sapiens]
          Length = 1002

 Score =  265 bits (678), Expect = 1e-69
 Identities = 166/350 (47%), Positives = 218/350 (62%), Gaps = 19/350 (5%)

Query: 18  MQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPC 77
           +Q LQ E+E VQKRTFT+WIN HL K  PP+ V DLF D++DG  L+ALLEVLSG+ L  
Sbjct: 23  VQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLH 82

Query: 78  EQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEE 137
           E      RI  + NI  ALKFLE   +KLV+I++ +IADG PS+VLGL+W IIL+FQI+E
Sbjct: 83  EYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKE 142

Query: 138 LTSNLPQ---LQSLSSSASSVDSIVSSETPSPPSKRKV--TTKIQGNAKKALLKWVQYTA 192
           LT NL +     SLS  +   DS  SS  P+P ++R V  + K Q  A KALL WVQ   
Sbjct: 143 LTGNLSRNSPSSSLSPGSGGTDS-DSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKT 201

Query: 193 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 252
            K  G+ V+DF  SWRSG+AF +VI AI P LVD++     S RENLE AF+IA+  L I
Sbjct: 202 RKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQDALHI 260

Query: 253 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 312
           PRLL+PED+ VD PDE+SIMTYVAQFL+ +P++   + D  + D+ +P   +F    +  
Sbjct: 261 PRLLEPEDIMVDTPDEQSIMTYVAQFLERFPELE--AEDIFDSDKEVPIESTFVRIKETP 318

Query: 313 KREDRVIFKEMKVWIEQFERDLT------RAQMVESNLQDKYQSFKHFRV 356
             ++  +F    V  E  ER  T           +  + DK +S K FR+
Sbjct: 319 SEQESKVF----VLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRL 364


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score =  244 bits (623), Expect = 3e-63
 Identities = 427/2091 (20%), Positives = 813/2091 (38%), Gaps = 407/2091 (19%)

Query: 19   QRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCE 78
            ++LQDE+E VQK+TFTKW+NSHLA+      + DL+ D++DG  L+ LLEVLSG++LP  
Sbjct: 33   KQLQDEREAVQKKTFTKWVNSHLARVS--CRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90

Query: 79   QGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEEL 138
               RM RIH + N+  AL+FL+ +++ L N+ S DI DG   + LGL+WTIIL FQI++ 
Sbjct: 91   TKGRM-RIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQD- 148

Query: 139  TSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGI 198
                                +S ET     K+        +AK ALL W Q        +
Sbjct: 149  --------------------ISVETEDNKEKK--------SAKDALLLWCQMKTAGYPNV 180

Query: 199  EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDP 258
             + +F  SWR G+AF+++IH  RP+L+D + +K  +   NL++AF +AE  LG+ +LLDP
Sbjct: 181  NIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDP 240

Query: 259  EDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRV 318
            ED+ VD PDEKSI+TYV  +  ++  +   + +G+   ++L         ++ ++     
Sbjct: 241  EDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYES---- 296

Query: 319  IFKEMKVWIEQFERDLTRAQMVES--NLQDKYQSFKHFRVQYE----MKRKQIEHLIQPL 372
            +  ++  WIEQ    L   +   S   +Q + Q+F  +R   +     ++  +E L+  +
Sbjct: 297  LASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTI 356

Query: 373  H-------------RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLY 419
                          R+GKL  D   + ++W+R           L+K+            +
Sbjct: 357  QSKMRANNQKVYMPREGKLISD---INKAWER-----------LEKA-----------EH 391

Query: 420  RAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD-----------------AHKRA 462
              E+ALR E+  Q+  E+ A    RK    +  L                     A K+ 
Sbjct: 392  ERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK- 450

Query: 463  FHEIYRT------RSVNGIPVPPDQLEDMAERFHFVSSTS--------------ELHLMK 502
             HE   T        V  +     +LE  AE +H +   +              EL   +
Sbjct: 451  -HEAIETDIAAYEERVQAVVAVARELE--AENYHDIKRITARKDNVIRLWEYLLELLRAR 507

Query: 503  MEFLELKYRLLSLLV--------LAESKLKSWIIKYGRR-ESVEQLLQNYVSFIE----- 548
             + LE+   L  +          + E K+      YG+    VE LLQ + + +E     
Sbjct: 508  RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKH-TLVEADIGI 566

Query: 549  NSKFFEQYEVTYQILKQTAEMYVKADGSV-EEAENVMKFMNETTAQWRNLSVEVRSVRSM 607
             ++       + Q      E Y   D  V  +    M+F  +   Q   L+ E    R+ 
Sbjct: 567  QAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ---LAAE---RRAR 620

Query: 608  LEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMND----- 662
            LEE    W ++   +A  + W+ + EK+L+  +  K     ++   + +H A  D     
Sbjct: 621  LEESRRLW-KFFWEMAEEEGWIREKEKILSSDDYGKD--LTSVMRLLSKHRAFEDEMSGR 677

Query: 663  AGNF--LIETCDEMV------SRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT 714
            +G+F   I+  ++M+      S  ++++++ +  +W          A  +++  ++K+  
Sbjct: 678  SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW----------ANLEQLSAIRKKRL 727

Query: 715  DCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLIT 774
            +    L  F  +A                      +DI       DA    I K      
Sbjct: 728  EEASLLHQFQADA----------------------DDI-------DAWMLDILKIV---- 754

Query: 775  KESPQEEGKEMFATMSKLKEQLTKVKEC--YSPLL--YESQQLLIPLEELEKQMTSFYDS 830
              S  + G + ++T S +K+     +E   Y P L     Q   +P E  E       D 
Sbjct: 755  --SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESP-----DV 807

Query: 831  LGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLK 890
             G+++ I    +  A+ + L KQ  Q+          TL L +  S++    + +    +
Sbjct: 808  RGRLSGIEERYKEVAELTRLRKQALQD----------TLALYKMFSEADACELWIDEKEQ 857

Query: 891  HFDQTRLQRQIADIHV---AFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQ 947
              +  ++  ++ D+ V    F+S+  +  +    V   +++ ++   S    EK ++  Q
Sbjct: 858  WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 917

Query: 948  EGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQ 1007
            + L  +             F +L  R  +A L A       L   E +       K+ + 
Sbjct: 918  DKLNTRWSQ----------FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIES 967

Query: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
             +DL  +    +   +      R L ++E   ++L +E        +EK+  EH      
Sbjct: 968  TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE--------AEKLESEHP----- 1014

Query: 1068 KGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK 1127
                   ++   ++  L         + D       TLK   A++         +  K +
Sbjct: 1015 -------DQAQAILSRLA-------EISDVWEEMKTTLKNREASLG--------EASKLQ 1052

Query: 1128 DYTSRFSEFSSWISTNETQLKG-------IKGEAIDTANHGEVKRAVEEIRNGVTK---- 1176
             +     +F SW+S  +T +          + E + T  H  +K  ++       K    
Sbjct: 1053 QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLT-QHENIKNEIDNYEEDYQKMRDM 1111

Query: 1177 -----RGET---LSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLL---SEVE 1225
                 +G+T     +L+ RL+ L   +  NE  K  +    L S   A    L    + E
Sbjct: 1112 GEMVTQGQTDAQYMFLRQRLQALD--TGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAE 1169

Query: 1226 KMLSNFGDCVQYKEI-------------------VKNSLEELIS---------------G 1251
              L+N    + + E+                     ++ EE I+                
Sbjct: 1170 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNIN 1229

Query: 1252 SKEVQEQAEKILD--TENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR 1309
            S  +QE+ + I D   +N   A +LL+   +  + +    +D Q+      +      D 
Sbjct: 1230 SDRIQEKVDSIDDRHRKNRETASELLM-RLKDNRDLQKFLQDCQELSLWINEKMLTAQDM 1288

Query: 1310 GHEELRKLES----------------------TLDGLERSRERQERRIQVTLR------K 1341
             ++E R L S                        +G++   E+ E    V  +       
Sbjct: 1289 SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKM 1348

Query: 1342 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE---QTKEFSKRTESIAVQAEN 1398
            WE  E+  +T  + LF    +     S + L+     LE   Q+ ++ K   S+ +  + 
Sbjct: 1349 WEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKK 1408

Query: 1399 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT----LEEDIKTMEMVK--------- 1445
                 +++ +  +  + LQ QA+++ ++ K  ++     L    K ME+++         
Sbjct: 1409 QQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNL 1468

Query: 1446 --TKWDH-FGSNFETLSVWITEKEKELNALETSSSAMDMQ--ISQIKVTIQEIESKLSSI 1500
              +K  H F  + E   +W+ E+     + +   +   +Q  I + +   +EI+     I
Sbjct: 1469 LASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRI 1528

Query: 1501 VGLEEEAQSFAQFVTTGESARIKAKLTQIRRYG----EELREHAQCLEGTILGHLSQQQK 1556
              + E +Q+     ++  +  I+ +L  +++      EE  +  + LE     H +QQ  
Sbjct: 1529 DDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEE---AHRAQQYY 1585

Query: 1557 FEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA 1616
            F+    +   S  E         K   SA     +L++H  L QA+E  +  +   S ++
Sbjct: 1586 FDAAEAEAWMSEQELYMMSEEKAKDEQSAV---SMLKKHQILEQAVEDYAETVHQLSKTS 1642

Query: 1617 RKVVNRDSCVQEAAALQQQ-----YEDILRRAKERQTALENLLAHWQRLEKELSSFLTWL 1671
            R +V       E  +++Q      Y  +   A+ER+  L+     +Q L +E+     W+
Sbjct: 1643 RALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ-LNREVDDLEQWI 1701

Query: 1672 ERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDD 1731
               E  A S E+    + V +  E     A     + Q      +  L + L +    D 
Sbjct: 1702 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER-VDTVNHLADELINSGHSDA 1760

Query: 1732 VKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTT 1791
              + +   + L+E W DL ++I+ R   L +    H+ + +   +  ++ ++     +  
Sbjct: 1761 ATIAEWK-DGLNEAWADLLELIDTRTQILAASYELHKFYHD---AKEIFGRIQDKHKKLP 1816

Query: 1792 SEISIMDHQVALTRHKDHAA---EVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAED 1848
             E+   D     T  + H     ++++   +++ LQ   A+L +    +    +Q +  +
Sbjct: 1817 EELG-RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1875

Query: 1849 CFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1899
              + ++      E R++ L    +  +  + +  ++  +   +    +  K
Sbjct: 1876 VLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEK 1926



 Score =  135 bits (339), Expect = 2e-30
 Identities = 295/1654 (17%), Positives = 650/1654 (39%), Gaps = 170/1654 (10%)

Query: 2967 QALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEIL---DALQKAEPRTEDLKSQL 3023
            Q LE    L K + + L +++  +  + +V     G+ +L   D LQK      D+  Q 
Sbjct: 509  QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 568

Query: 3024 NELC-------RFSRDLSTYSGKVSGLIKE--------YNCLC-LQASKGCQNKEQILQQ 3067
              +        +F+ D   Y      +I++        Y  LC L A +  + +E     
Sbjct: 569  ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 628

Query: 3068 RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK 3127
            +F     + + W +  K       D  ++++ V   L K + F  E           + +
Sbjct: 629  KFFWEMAEEEGW-IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKE 687

Query: 3128 GELLSTLLTKEK--AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI 3185
            GE    ++ +E   ++ I+ ++   +E W N       ++  LE   + +  F+  A+ I
Sbjct: 688  GE---DMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDI 743

Query: 3186 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3245
              W+    K+V  SS+  +D  + +   +K + V EEI  Y P L+ L E+A  L +  A
Sbjct: 744  DAWMLDILKIV-SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHA 802

Query: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFS------LGIKELQDWMTDA 3299
             S   R R+S +  +Y  ++ LT+ +   L   +A +  FS      L I E + W+ + 
Sbjct: 803  ESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM 862

Query: 3300 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3359
                        D  V+  R   LE  ++ +  +   +  I  +    L ++       I
Sbjct: 863  -----QIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEI 913

Query: 3360 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3419
            + Q   +   W+       R K  L  ALS   +Y     +   W+      +  ++   
Sbjct: 914  KAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKSWIREKTKVIESTQDLG 972

Query: 3420 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQ--------LELQDLQE 3471
             +L     +  K   +  ++++  + L  ++ +   +   +  Q         E+ D+ E
Sbjct: 973  NDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1032

Query: 3472 RYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQ----------------EKL 3515
              +   +  + ++ ++ KL    Q++ RDL  F+ WL + Q                + L
Sbjct: 1033 EMKTTLKNREASLGEASKL----QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1088

Query: 3516 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3575
             Q+  ++ +   +E   + ++++     +GQ      +  R+ +      QA D     L
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDA-QYMFLRQRL------QALDTGWNEL 1141

Query: 3576 RQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE 3635
             + W+  Q+ LS++        +  +   +  +Q + +L   +E V   T   +     E
Sbjct: 1142 HKMWENRQNLLSQS--------HAYQQFLRDTKQAEAFLNN-QEYVLAHTEMPTTLEGAE 1192

Query: 3636 IQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNS-RMGCQATQLTSRYQ------A 3688
              + + + +   + A  +++  V    + ++ + ++NS R+  +   +  R++      +
Sbjct: 1193 AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETAS 1252

Query: 3689 LLLQVLEQIKFLEEEIQSLEE-----SESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
             LL  L+  + L++ +Q  +E     +E  L++    Y       +N+ +K  K    M 
Sbjct: 1253 ELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEA----RNLHSKWLKHQAFM- 1307

Query: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
              +L + +  L  +EK    L S + + E  VK    G        +H   E L+  T T
Sbjct: 1308 -AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--------LHKMWEVLESTTQT 1358

Query: 3804 VRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQ 3863
              +      K    A+ F+  C  L +W+   +  +   +  K +L      L K + L+
Sbjct: 1359 KAQRLFDANK----AELFTQSCADLDKWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLE 1413

Query: 3864 QTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQ----LQSDYQDLCSIGKEHVFSLEA 3919
              +   +  ++ ++ + +A   L Q+    D++D     +Q+ + +L     E   +L A
Sbjct: 1414 NQMEVRKKEIEELQSQAQA---LSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1470

Query: 3920 KVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDR 3979
              + H+ +N ++++   W+ +      + D     +L+T+   +  ++ + +EI G + R
Sbjct: 1471 SKEIHQ-FNRDVEDEILWVGERMPLATSTD--HGHNLQTVQLLIKKNQTLQKEIQGHQPR 1527

Query: 3980 LNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE--HELQK 4037
            ++++  +   ++   +      ++Q     L   K  +  +    ++ ++ LE  H  Q+
Sbjct: 1528 IDDIFERSQNIVTDSSSLSAEAIRQ----RLADLKQLWGLLIEETEKRHRRLEEAHRAQQ 1583

Query: 4038 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4097
            +        + +AW+S  Q     S +       A+  +K  + L++    Y + +  + 
Sbjct: 1584 YYF---DAAEAEAWMSE-QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLS 1639

Query: 4098 DLSNASVKTT---AKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWIYLQDADQ 4151
              S A V  +   ++ I   +  +++     ++L +   G  + +H   +L   + D +Q
Sbjct: 1640 KTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQ 1699

Query: 4152 QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV-NTIIEKVNKLTKKEESPEHKE 4210
             +   +      EL      V+ +++  ++      ++    ++ VN L  +  +  H +
Sbjct: 1700 WIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSD 1759

Query: 4211 I-------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL 4263
                    + LN+ W DL    +          +  + YHD   +     +K     + L
Sbjct: 1760 AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEEL 1819

Query: 4264 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNL----DDKELVKEQTS 4319
             R         +E L+++    +    A+     Q Q+    L      D  + ++++ +
Sbjct: 1820 GRDQNT-----VETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKREN 1874

Query: 4320 HLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4379
             + + W  L D  + + +V + +  +     S  ++LM W E+    I +   Q  P D+
Sbjct: 1875 EVLEAWKSLLDACESR-RVRLVDTGDKFRFFSMVRDLMLWMEDV---IRQIEAQEKPRDV 1930

Query: 4380 A--QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCL 4437
            +  + L+ +H  I +E++A+     + I+    ++A       ++ +K L   +     +
Sbjct: 1931 SSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI 1990

Query: 4438 SDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCK 4497
             D    R ++L + + E  QF      A + +   E  +  RE I    D+V K +K  +
Sbjct: 1991 -DKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSRE-IGQSVDEVEKLIKRHE 2047

Query: 4498 SAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSE 4531
            + + S  T+    + L       + EV  Q++ E
Sbjct: 2048 AFEKSAATWDERFSALERLTTLELLEVRRQQEEE 2081



 Score =  124 bits (312), Expect = 3e-27
 Identities = 308/1695 (18%), Positives = 668/1695 (39%), Gaps = 222/1695 (13%)

Query: 6634 FQGLESHMILTETLFRKIISFAVQKETQFHTELM------AQASAVLKRAHKRGVELEYI 6687
            F   E H+ LT+ L  + IS     E    T ++      ++  A+     + G  L+  
Sbjct: 225  FNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNA 284

Query: 6688 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQ---- 6743
            +ET   +++ +   S  LE +E +I     +  N  +  + +   Q    + N Y+    
Sbjct: 285  IETEKMIEKYESLASDLLEWIEQTI-----IILNNRKFANSLVGVQQQLQAFNTYRTVEK 339

Query: 6744 PKLYQVLDDGKRLLISISC------------------SDLESQLNQLGECWLSNTNKMSK 6785
            P  +    + + LL +I                    SD+     +L +        +  
Sbjct: 340  PPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRN 399

Query: 6786 ELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEF 6845
            EL R E + +   R+  ++A    WL S   RL         +P      + H       
Sbjct: 400  ELIRQEKLEQLARRFDRKAAMRETWL-SENQRLVSQDNFGFDLPAVEAATKKHE----AI 454

Query: 6846 SKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ- 6904
              ++ A      +V++   +L      D   + +    +   W  LL  + A +++L   
Sbjct: 455  ETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMN 514

Query: 6905 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQ 6964
            L + K+     +  +M W+  M+ V+   +D  K+ +G   + + LQK+   + DI  + 
Sbjct: 515  LGLQKIFQE--MLYIMDWMDEMK-VLVLSQDYGKHLLG---VEDLLQKHTLVEADIGIQA 568

Query: 6965 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 7024
              V  VN S  + ++     K  D     +++  M   +Q L  L  E+   LE     W
Sbjct: 569  ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 628

Query: 7025 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7084
              +    +  + W   +EK L       D  SV   L   +  ED +  +    E+  + 
Sbjct: 629  KFFWEMAE-EEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKE 687

Query: 7085 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7144
            G  +I  +    S  +   +  + + WANL+    QL  + K  L++ S           
Sbjct: 688  GEDMIAEEHFG-SEKIRERIIYIREQWANLE----QLSAIRKKRLEEASL---------- 732

Query: 7145 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7204
                    L +F+     ++A  + +  + +   D+   E S       T  L+K+ H  
Sbjct: 733  --------LHQFQADADDIDAWMLDILKIVS-SSDVGHDEYS-------TQSLVKK-HKD 775

Query: 7205 VTETLTN---TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
            V E + N   TL  ++ + + L +E AE       L  + +RYK+ ++      Q  +D 
Sbjct: 776  VAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQD- 834

Query: 7262 TNELLKAATNKDIAD---DEVATWIQDCN--DLLKGLGTVK--------------DSLFF 7302
            T  L K  +  D  +   DE   W+ +    + L+ L  ++                +  
Sbjct: 835  TLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAV 894

Query: 7303 LHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362
            ++++  QL      S    I++ Q  L+       + + +++ +L +  L  + +     
Sbjct: 895  VNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQNYHLECN 952

Query: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL 7422
              ++WI E  ++++       +DL+ +     +L G      ++   L  L +   +L  
Sbjct: 953  ETKSWIREKTKVIESTQDL-GNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1011

Query: 7423 NDKE-----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7477
               +     + R+  ++  W  + +    R + L     + Q FL   + +  +L +T+ 
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGE-ASKLQQFLRDLDDFQSWLSRTQT 1070

Query: 7478 KLAVEISGNY----QHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7533
             +A E   N     + LL Q   HE  + E+ + ++    +   G+ ++ QGQ D +  F
Sbjct: 1071 AIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMF 1126

Query: 7534 -NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7592
               +L  L   W  + +  + R+ ++ SQ   +Q++    ++   +L    Y+       
Sbjct: 1127 LRQRLQALDTGWNELHKMWENRQNLL-SQSHAYQQFLRDTKQAEAFLNNQEYVLAHT--E 1183

Query: 7593 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 7652
            +P  L+ A     + +         +      VE G++L+   +  ++  +Q ++  I +
Sbjct: 1184 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR-IQEKVDSIDD 1242

Query: 7653 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE---LHA 7709
            + +    +  E   +L   LKD    +K + D  E      +K+  +    ++E   LH+
Sbjct: 1243 RHR----KNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHS 1298

Query: 7710 EQMRCKELENAVGS---WTDDLTQ--LSLLKDTLSAYISADDISILNERVELLQRQWEEL 7764
            + ++ +     + S   W D + +  + L+ +        +  +++ E++  L + WE L
Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQLISE------KPETEAVVKEKLTGLHKMWEVL 1352

Query: 7765 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKD 7821
                  + Q++ +  N+  +F++   +L +WL  +ES++  +    D+    ++ K ++ 
Sbjct: 1353 ESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQM 1411

Query: 7822 YQEEIAIAQENKIQLQQMGERLAKASHESKAS-EIEYKLGKVNDRWQHLLDLIAARVKKL 7880
             + ++ + ++   +LQ   + L   S E K++ E++ K   V  ++  LL+ +  R    
Sbjct: 1412 LENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNER---- 1464

Query: 7881 KETLVA---VQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7937
            K  L+A   + Q ++++     W+      LA    +   N + +Q  + + Q LQ++I+
Sbjct: 1465 KHNLLASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGH-NLQTVQLLIKKNQTLQKEIQ 1522

Query: 7938 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 7997
             H   +  +    + ++ D  + + +A    I+Q   +L + W  +   + +R  ++EE 
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEA----IRQRLADLKQLWGLLIEETEKRHRRLEEA 1578

Query: 7998 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEE----------LKKFEAFQR 8047
             R  Q++  D +  E W+   E           +Y +++E+          LKK +  ++
Sbjct: 1579 HRA-QQYYFDAAEAEAWMSEQE-----------LYMMSEEKAKDEQSAVSMLKKHQILEQ 1626

Query: 8048 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI 8107
             V +    +  ++K  R L  ++  +S     + +     + D L   +  +    +  +
Sbjct: 1627 AVEDYAETVHQLSKTSRALVADSHPES-----ERISMRQSKVDKLYAGLKDLAEERRGKL 1681

Query: 8108 GQREE-FETAR--DSILVWLTEMDLQLTNIEHFSECDVQAKIKQ-LKAFQQEI-SLNHNK 8162
             +R   F+  R  D +  W+ E ++   + E   + +    +++  + F ++  ++   +
Sbjct: 1682 DERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER 1741

Query: 8163 IEQIIAQGEQLIEKSEPLDAAIIEEELD------------------------ELRRY--- 8195
            ++ +    ++LI      DAA I E  D                        EL ++   
Sbjct: 1742 VDTVNHLADELINSGHS-DAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHD 1800

Query: 8196 CQEVFGRVERYHKKL 8210
             +E+FGR++  HKKL
Sbjct: 1801 AKEIFGRIQDKHKKL 1815



 Score =  124 bits (311), Expect = 4e-27
 Identities = 311/1735 (17%), Positives = 655/1735 (37%), Gaps = 240/1735 (13%)

Query: 1437 DIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL-NALETS-------SSAMDMQISQIKV 1488
            D K++      + H+ S  + L+V      K L NA+ET        S A D+ +  I+ 
Sbjct: 249  DEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDL-LEWIEQ 307

Query: 1489 TIQEIESK--LSSIVGLEEEAQSFAQFVTTGESARIKAK--------------------- 1525
            TI  + ++   +S+VG++++ Q+F  + T  +  +   K                     
Sbjct: 308  TIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV 367

Query: 1526 --------LTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV 1577
                    ++ I +  E L +     E  +   L +Q+K E+  R+  +  +  E  L+ 
Sbjct: 368  YMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE 427

Query: 1578 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1637
              ++ S     +  L       +  E++ + I A+    + VV   +  +E  A  + Y 
Sbjct: 428  NQRLVSQDNFGFD-LPAVEAATKKHEAIETDIAAYEERVQAVV---AVARELEA--ENYH 481

Query: 1638 DILRRAKERQTA-------LENLLAHWQRLE---------KELSSFLTWLERGEAKASSP 1681
            DI R    +          LE L A  QRLE         +E+   + W++  +    S 
Sbjct: 482  DIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQ 541

Query: 1682 E---------------------MDISADRVK-VEGELQLI------------QALQNEVV 1707
            +                     + I A+RV+ V    Q              Q +++ V 
Sbjct: 542  DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 601

Query: 1708 SQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDER-W-RDLPQIIN-----KRINFL 1760
                 Y +L QL         ++  ++ K   E  +E  W R+  +I++     K +  +
Sbjct: 602  HMEFCYQELCQLAAER-RARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSV 660

Query: 1761 QSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGEL 1820
              ++++H+ F++ +   S   +  + E     E  I +      + ++    +  +   L
Sbjct: 661  MRLLSKHRAFEDEMSGRSGHFEQAIKE----GEDMIAEEHFGSEKIRERIIYIREQWANL 716

Query: 1821 QSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA--EFLQSHA 1878
            + L     K   L  A  LH  Q  A+D      +  ++V    +     +    ++ H 
Sbjct: 717  EQLSAIRKK--RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 774

Query: 1879 SLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLK 1938
             ++  +   R T++   ++++  S L ++             + +  + G LS  +   K
Sbjct: 775  DVAEEIANYRPTLD---TLHEQASALPQE------------HAESPDVRGRLSGIEERYK 819

Query: 1939 IGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIE 1998
              +   R   +A  D L          L    SEADA  +    + D+KE+ L +++  E
Sbjct: 820  EVAELTRLRKQALQDTLA---------LYKMFSEADACEL----WIDEKEQWLNNMQIPE 866

Query: 1999 ERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDR 2058
            +  D E         +Q R   F  LE E+N+    +  +   A+Q+         E+  
Sbjct: 867  KLEDLE--------VIQHR---FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915

Query: 2059 EINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQ 2118
            + ++L   W   + L+   +      + +   +       S + E           I+  
Sbjct: 916  QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK-------VIEST 968

Query: 2119 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKI---HSSDFSLVKTDMESTV 2175
            +DL    +     + K+   ++DL    +K   L  E +K+   H      + + +    
Sbjct: 969  QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEIS 1028

Query: 2176 DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-RAE 2234
            D W ++   L+ N +      S     L   D+ + W +     +A    ++ N L  AE
Sbjct: 1029 DVWEEMKTTLK-NREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DMPNTLTEAE 1085

Query: 2235 ELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEV 2294
            +LL + E+ +KN+    EE + K+ D+ E+    +T     F+   L        E+ ++
Sbjct: 1086 KLLTQHEN-IKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKM 1144

Query: 2295 AKGTLKDFTAQSTQVEKFINDIT---TWFTKVEESLMNCAQNETCE----ALKKVKDIQK 2347
             +   ++  +QS   ++F+ D      +    E  L +     T E    A+KK +D   
Sbjct: 1145 WENR-QNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMT 1203

Query: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
             + + +  I++  E    L     +   + +   +  +  +H    +  S+    L+++ 
Sbjct: 1204 TMDANEEKINAVVETGRRLVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR 1262

Query: 2408 E-KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2466
            + + F +  QE   W       A++ S    +++ L +K    Q  +  ++  +  LD +
Sbjct: 1263 DLQKFLQDCQELSLWINEKMLTAQDMS--YDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320

Query: 2467 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
             +EG  L +    +  + ++E++T  ++ ++          Q L D A++   F      
Sbjct: 1321 EKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCAD 1378

Query: 2527 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
            L+ W+H +E +  +++ G+    +      + K +M   ++   ++ +++L  + Q LS+
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSV---NILLKKQQMLENQMEVRKKEIEELQSQAQALSQ 1435

Query: 2587 EGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDR 2646
            EG    +       + T    LL    E+  +   + + H+     ++    WV    +R
Sbjct: 1436 EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ-FNRDVEDEILWVG---ER 1491

Query: 2647 LACAESTLGSKD--TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQ 2704
            +  A ST    +  T++  + + Q +       + +++    + +  +  S+      I+
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551

Query: 2705 TQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQP 2764
             +L  LK++W  ++  +      LE        Y +   + E WM   +Q++    + + 
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA-EAEAWMS--EQELYMMSEEKA 1608

Query: 2765 GLKEKFVLLDHLQSILSEA-EDHTRALHRLIAKSRELYEKTEDESFK-DTAQEELKTQFN 2822
              ++  V +     IL +A ED+   +H+L   SR L   +  ES +    Q ++   + 
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668

Query: 2823 DIMTVAKEKMRKVEEIVKDHLMYLD-AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2881
             +  +A+E+  K++E  +  L  L+  V +   W+ + +E +    ++  D         
Sbjct: 1669 GLKDLAEERRGKLDE--RHRLFQLNREVDDLEQWI-AEREVVAGSHELGQDYEHVTMLQE 1725

Query: 2882 KIKELI-DSREIGASRLSRVESLAPEV-----------------KQNTTASGCELMHTEM 2923
            + +E   D+  IG  R+  V  LA E+                      A   EL+ T  
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785

Query: 2924 QALRADW--------------------KQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA 2963
            Q L A +                    K+  + + + Q+ +E L       E +      
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGT 1845

Query: 2964 QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
            Q+ Q  E  + L   +A      + +  + E++E W   + +LDA +    R  D
Sbjct: 1846 QVRQLQEDAARLQAAYAGD-KADDIQKRENEVLEAW---KSLLDACESRRVRLVD 1896



 Score =  119 bits (299), Expect = 1e-25
 Identities = 310/1823 (17%), Positives = 686/1823 (37%), Gaps = 245/1823 (13%)

Query: 3154 WKNFHSNLHQKESALENLKIQMKDFEVSAEPI-------QDWLSKTEKMVHESSNRLYDL 3206
            W+      H++E AL N  I+ +  E  A          + WLS+ +++V +  N  +DL
Sbjct: 383  WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD-NFGFDL 441

Query: 3207 PAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALS 3265
            PA     +K +++  +I  YE ++  +   A++L  E     K    R   +   +  L 
Sbjct: 442  PAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLL 501

Query: 3266 NLTKEKVSRLDRIVAEHNQFS--LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL 3323
             L + +  RL+  +     F   L I +  D M   +   D   H    + +L   TL +
Sbjct: 502  ELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTL-V 560

Query: 3324 EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQ 3383
            EA + ++ E+   +     +  +  +   P     I+ ++  ++  +  L       +++
Sbjct: 561  EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRAR 620

Query: 3384 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYS 3443
            LE +   W  + + + +  GW+   E  L+ S+    +L     +L K +   +E+   S
Sbjct: 621  LEESRRLWKFFWE-MAEEEGWIREKEKILS-SDDYGKDLTSVMRLLSKHRAFEDEMSGRS 678

Query: 3444 SLLETIEVKGAGM--TEHYVTQL---ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3498
               E    +G  M   EH+ ++     +  ++E++  +++ +     + E+   LHQ +Q
Sbjct: 679  GHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ-FQ 737

Query: 3499 RDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRED 3558
             D    + W+  +  K+   S +  D ++ ++ ++  +++    A  +  L++ LH +  
Sbjct: 738  ADADDIDAWM-LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDT-LHEQAS 795

Query: 3559 VIP-------------SGIPQAEDRALESLR----------------------------- 3576
             +P             SGI +      E  R                             
Sbjct: 796  ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEK 855

Query: 3577 -------------QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQV-------DEWLKT 3616
                         +D +  QHR      + NN  +++ ++ Q  +Q+       ++ +K 
Sbjct: 856  EQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915

Query: 3617 AEEKVSPRTRRQSNRATKE--------------IQLHQMKKWHEEVTAYRDEVEEVG--- 3659
             ++K++ R  +      ++              ++ ++ K W  E T   +  +++G   
Sbjct: 916  QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDL 975

Query: 3660 -----------ARAQEILDESHVNSRMGCQATQLTSRY----QALLLQVLEQIKFLEEEI 3704
                          ++++      S +  +A +L S +    QA+L ++ E     EE  
Sbjct: 976  AGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMK 1035

Query: 3705 QSLEESESSLSSYS---------DWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL-EVLL 3754
             +L+  E+SL   S         D + S     +      D  +T+   +KL T  E + 
Sbjct: 1036 TTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIK 1095

Query: 3755 KDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKG 3814
             +++      +  R+ GE   +   + +   LR+ +        EL          L + 
Sbjct: 1096 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1155

Query: 3815 LHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVK 3874
             H  ++F    K    ++   + +L   E P   L   +A + K +    T+ ++E  + 
Sbjct: 1156 -HAYQQFLRDTKQAEAFLNNQEYVLAHTEMP-TTLEGAEAAIKKQEDFMTTMDANEEKIN 1213

Query: 3875 SVREKGEALLELVQDVTL-KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQE 3933
            +V E G     LV D  +  D+I +      D     +E    L  ++KD+ D    LQ+
Sbjct: 1214 AVVETGR---RLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD 1270

Query: 3934 VEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQ 3993
             ++  L ++ +++    +       +  +   H+A M E+A  ++ L+ ++ +G  LI +
Sbjct: 1271 CQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE 1330

Query: 3994 CADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLS 4053
                 + + +  V   L G    +  + ST Q   Q L  +  K      +      WL 
Sbjct: 1331 -----KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL-FDANKAELFTQSCADLDKWLH 1384

Query: 4054 AVQPDLEPSP--QPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDI 4111
             ++  ++     +   S    +K+ +      E  +  ++ L S     +   K+T  ++
Sbjct: 1385 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST-DEV 1443

Query: 4112 QQTEQTIEQKLVQAQNLTQGWEEIKH---LKSELWIYLQDADQQLQNMKRR--------H 4160
                 T++ K ++   L +   E KH      E+  + +D + ++  +  R        H
Sbjct: 1444 DSKRLTVQTKFME---LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDH 1500

Query: 4161 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINH----LND 4216
                L   Q ++ + +   K++Q  Q  ++ I E+   +     S   + I      L  
Sbjct: 1501 GH-NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQ 1559

Query: 4217 QWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLE 4276
             W  L  ++     + EE  +  + Y D         E+           D +S    L+
Sbjct: 1560 LWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1619

Query: 4277 ALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI 4336
              + L  A+++    +  L    + ++   +  + E +  + S +++ +  L+DL + + 
Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSH-PESERISMRQSKVDKLYAGLKDLAEER- 1677

Query: 4337 QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA 4396
            +  +     L  +     +L +W       IAE    +   ++ Q+   +H+        
Sbjct: 1678 RGKLDERHRLFQLNREVDDLEQW-------IAEREVVAGSHELGQD--YEHVT------- 1721

Query: 4397 KQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA----- 4451
               +L+   ++  R   ++G      +     +  +  +  +  + + +  LN+A     
Sbjct: 1722 ---MLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1778

Query: 4452 --LSEKTQFLMAVFQATSQIQQHERKIMF---REHICLLPDDVSKQVKTCKSAQASLKTY 4506
              +  +TQ L A ++       H+ K +F   ++    LP+++ +   T ++ Q    T+
Sbjct: 1779 ELIDTRTQILAASYELHK--FYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1836

Query: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
            ++++  L  Q R+L ++    + +    K  ++Q   + VL+     L   E     R  
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR---RVR 1893

Query: 4567 FKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTG 4626
              +  DK   +    D++ + E                  +++ Q    E       R  
Sbjct: 1894 LVDTGDKFRFFSMVRDLMLWME------------------DVIRQIEAQEK-----PRDV 1930

Query: 4627 QTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYAS------LI 4680
             ++   +N  +H  +  +++A    F   + L K        ++LARK YAS      L+
Sbjct: 1931 SSVELLMN--NHQGIKAEIDARNDSFTTCIELGK--------SLLARKHYASEEIKEKLL 1980

Query: 4681 ELTTQSLSELE---------AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD 4731
            +LT +    ++            L + +   D +V EA  L         E+    + V+
Sbjct: 1981 QLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVE 2040

Query: 4732 ELNQKKEGFRSTGQPW-QPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4790
            +L ++ E F  +   W +    L  +T    L+ + +Q     +    + +   K+ ++ 
Sbjct: 2041 KLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEA 2100

Query: 4791 ERQLKSVKEEQSKVNEETLPAEE 4813
            E Q +    +  +V++  LPAE+
Sbjct: 2101 ESQQQWDTSKGEQVSQNGLPAEQ 2123



 Score =  117 bits (294), Expect = 4e-25
 Identities = 315/1595 (19%), Positives = 599/1595 (37%), Gaps = 234/1595 (14%)

Query: 7163 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNN 7222
            ++A+ V+   +  + D+  + E+ ++K+ S+ + LL        E +  T+  +N R   
Sbjct: 267  MKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL--------EWIEQTIIILNNR--- 315

Query: 7223 LLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR---TNELLKAATNKDIADDEV 7279
               + A  L   +  LQ +  Y+   K    T +   +    T +    A N+ +     
Sbjct: 316  ---KFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE 372

Query: 7280 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7339
               I D N   + L   +      HE    L+ ++       I+ ++L         + A
Sbjct: 373  GKLISDINKAWERLEKAE------HERELALRNEL-------IRQEKLEQLARRFDRKAA 419

Query: 7340 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7399
            + +   S    ++  + F   L A+EA   + E I         +D++  +ER++ +   
Sbjct: 420  MRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAI--------ETDIAAYEERVQAVV-- 469

Query: 7400 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7459
                 ++A +L+  N    +     +   R  N+ R W  +      R  +L+  L   +
Sbjct: 470  -----AVARELEAENYHDIK-----RITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 519

Query: 7460 TFLEKCET--WMEFLVQTEQKLAVEISGNYQHLLEQQ---RAHELFQAEMFSRQQILHSI 7514
             F E      WM+     E K+ V      +HLL  +   + H L +A++  + + +  +
Sbjct: 520  IFQEMLYIMDWMD-----EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGV 574

Query: 7515 IIDGQRLLEQGQ---VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 7571
                Q+    G+     D      ++  +   +Q + + A +RR  ++   R W+ + EM
Sbjct: 575  NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634

Query: 7572 AEKLRKWLVEVSYLPMSG-----LGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7626
            AE+   W+ E   +  S      L SV   L + R   DE+  +        G +   ++
Sbjct: 635  AEE-EGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRS-------GHFEQAIK 686

Query: 7627 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL--AFLLKDWEKCEKGIAD 7684
             G+ ++     G+E  ++  +  I+E+W +       +KK+L  A LL  ++      AD
Sbjct: 687  EGEDMIAEEHFGSEK-IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQ----ADAD 741

Query: 7685 SLEKLRTFKKKLSQSLPDHHEELHAEQM--RCKELENAVGSWTDDLTQLSLLKDTL-SAY 7741
             ++       K+  S    H+E   + +  + K++   + ++   L  L      L   +
Sbjct: 742  DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEH 801

Query: 7742 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK------ELCEW 7795
              + D+     R+  ++ +++E+     LR+Q + + L  + +FSE +       E  +W
Sbjct: 802  AESPDV---RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQW 858

Query: 7796 LTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEI 7855
            L  M+         +I+   E L+ +   + +        + Q+  +L  + H S+  EI
Sbjct: 859  LNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS----RVAVVNQIARQLMHSGHPSE-KEI 913

Query: 7856 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7915
            + +  K+N RW    +L+  +   L   L ++Q      +  ++W+        K  V +
Sbjct: 914  KAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIRE------KTKVIE 966

Query: 7916 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7975
            S  ++++   L     LQR +    TG+   L   E  L D    A   E +   QA   
Sbjct: 967  S--TQDLGNDLAGVMALQRKL----TGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1020

Query: 7976 LDRR------WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 8029
            L R       W  +      R   + E  +L Q+FL D   F+ WL  ++   A      
Sbjct: 1021 LSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPN 1079

Query: 8030 VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS-LKQMVHEGNQR 8088
             + T A++ L + E  + ++       + + +    +  + +TD+    L+Q +   +  
Sbjct: 1080 TL-TEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYMFLRQRLQALDTG 1137

Query: 8089 WDNLQK------RVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLTNIEHFSE 8139
            W+ L K       + S     + F+    Q E F   ++ +L   TEM   L   E    
Sbjct: 1138 WNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPTTLEGAE---- 1192

Query: 8140 CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 8199
                A IK+ + F   +  N  KI  ++  G +L+     +++  I+E++D +       
Sbjct: 1193 ----AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN-INSDRIQEKVDSI------- 1240

Query: 8200 FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL 8259
                             DD H   +RE   E    L D    +R     L  Q    LSL
Sbjct: 1241 -----------------DDRHR-KNRETASELLMRLKD----NRDLQKFL--QDCQELSL 1276

Query: 8260 SLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLES------AMSRALPSEDE----- 8308
             + + + + +                D  YD +R+L S      A    L S  E     
Sbjct: 1277 WINEKMLTAQ----------------DMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320

Query: 8309 ---------EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIR-S 8358
                     E  + +        GL      LES  +   + L D+      T++     
Sbjct: 1321 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1380

Query: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTA 8415
            K   G E       Y K L   +  +   + LE+++   K+E E L       S E ++ 
Sbjct: 1381 KWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST 1440

Query: 8416 GVIDRWELLQAQALSKEL-----RMKQNL---QKWQQFNSDLNSIWAWLGDTEEELEQLQ 8467
              +D  + L  Q    EL       K NL   ++  QFN D+     W+G   E +    
Sbjct: 1441 DEVDS-KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVG---ERMPLAT 1496

Query: 8468 RLELSTDIQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQ 8526
              +   ++QT++L IKK + LQK +  H+  I           T + S  +  ++ RL+ 
Sbjct: 1497 STDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLAD 1556

Query: 8527 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 8586
            +   W  +    E+    L++A    Q + + +     M E      +E    D      
Sbjct: 1557 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVS 1616

Query: 8587 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV---NAEGTDCLEAKEKVHVIGNRLK 8643
            +L+ H     QI  + +E           + + LV   + E       + KV  +   LK
Sbjct: 1617 MLKKH-----QILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLK 1671

Query: 8644 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8678
             L +E    + E  +L  ++    DL  W +  E+
Sbjct: 1672 DLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV 1706



 Score =  116 bits (290), Expect = 1e-24
 Identities = 371/1932 (19%), Positives = 735/1932 (38%), Gaps = 250/1932 (12%)

Query: 5937 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP 5996
            + D+ ++WE L+    E++  L   L RQ+K +   +    K    E  LSE+       
Sbjct: 376  ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR----- 430

Query: 5997 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 6056
                          L+ QD                + EA   +  A+++ +    ER+  
Sbjct: 431  --------------LVSQDNFG---------FDLPAVEAATKKHEAIETDIAAYEERVQA 467

Query: 6057 IRMKASGKRQLLEEKLND-QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKE 6115
            +   A   R+L  E  +D +    R++  ++ +    + L   L + +  L+  L   K 
Sbjct: 468  VVAVA---RELEAENYHDIKRITARKDNVIRLW----EYLLELLRARRQRLEMNLGLQKI 520

Query: 6116 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL-KG 6174
              +M   +MD  +     E KV+ LS+                 D  + L G    L K 
Sbjct: 521  FQEM-LYIMDWMD-----EMKVLVLSQ-----------------DYGKHLLGVEDLLQKH 557

Query: 6175 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV-------QEWLAQARTTWTQQR 6227
            +L+E    +  +++     + +K  +D +      P V        E+  Q       +R
Sbjct: 558  TLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAER 617

Query: 6228 QSSLQQQKELEQ---ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGM 6284
            ++ L++ + L +   E+AE++  +R      E+IL   S+ +   D      +LS+    
Sbjct: 618  RARLEESRRLWKFFWEMAEEEGWIREK----EKIL---SSDDYGKDLTSVMRLLSKHRAF 670

Query: 6285 EGEKSSA----EDQMRMKWESLHQEFSTKQKLLQNVLE-QEQ----EQVLYSRPNRLLSG 6335
            E E S      E  ++   + + +E    +K+ + ++  +EQ    EQ+   R  RL   
Sbjct: 671  EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 730

Query: 6336 VPLYKGDVPTQDKSA----VTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6391
              L++      D  A    +  ++   +   +E S+QS   K + +  E   Y       
Sbjct: 731  SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPT---- 786

Query: 6392 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6451
              LD + E+   A+AL  E  E+      +    I+E  +E+ +   L  QA        
Sbjct: 787  --LDTLHEQ---ASALPQEHAESPDVRGRL--SGIEERYKEVAELTRLRKQA-------- 831

Query: 6452 DVIEDTLGCLLGRLSLLDSVVNQRCHQ-MKERLQQILNFQNDLKVLFTSLADNKYIILQK 6510
              ++DTL  L    S  D+     C   + E+ Q + N Q   K+    +  +++  L+ 
Sbjct: 832  --LQDTLA-LYKMFSEADA-----CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 883

Query: 6511 LANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDE 6569
              N      A ++  + Q A   +        E+K + DKL       +EL  +    D 
Sbjct: 884  EMN----NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL--VDRKKDA 937

Query: 6570 LMMIIGSRRSGLNQNLTL-----KSQYERALQDLADLLE---TGQEKMAGDQKIIVSSKE 6621
            L+  +  +   L  N T      K++   + QDL + L      Q K+ G ++ +V+ + 
Sbjct: 938  LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 997

Query: 6622 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 6681
            ++  L    KE  +    H    + +  ++   +         ++  +    LK      
Sbjct: 998  KLSDL---QKEAEKLESEHPDQAQAILSRLAEIS---------DVWEEMKTTLKNREASL 1045

Query: 6682 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 6741
             E   + +    LD+ Q  LSR    + S      L E  +      +T ++++K+ ++ 
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEK-----LLTQHENIKNEIDN 1100

Query: 6742 YQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
            Y+    ++ D G+ +    + +    L  +L  L   W    N++ K     + +L    
Sbjct: 1101 YEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW----NELHKMWENRQNLLSQSH 1156

Query: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTV-----PQELEMVRDHLNAFLEFSKEVDAQS 6853
             YQ        +L+  K    F   Q   +     P  LE     +    +F   +DA  
Sbjct: 1157 AYQQ-------FLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANE 1209

Query: 6854 SLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ--MDKLP 6911
               ++V+ TG +L+    +++  ++ ++  ID +      N     E L +L+   D   
Sbjct: 1210 EKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRK---NRETASELLMRLKDNRDLQK 1266

Query: 6912 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 6971
                  E+  WI+  E ++   + +   +   + +H    K++ F  ++   +  +D + 
Sbjct: 1267 FLQDCQELSLWIN--EKMLTAQDMSYDEA---RNLHSKWLKHQAFMAELASNKEWLDKIE 1321

Query: 6972 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 7031
            +  +Q+ S+  E++   K    E+L  ++K W++L+     K Q L    ++   +  + 
Sbjct: 1322 KEGMQLISEKPETEAVVK----EKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSC 1376

Query: 7032 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 7091
              L  W    E +++      D  SV   LK  Q LE+ ++ ++KE+E+++    AL Q 
Sbjct: 1377 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1436

Query: 7092 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL-MEAR 7150
             K   S+  + + R   QT      ++  L     ++L     H+   D  +  L +  R
Sbjct: 1437 GK---STDEVDSKRLTVQT--KFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGER 1491

Query: 7151 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLT 7210
              L+       +L+ VQ+ +   Q LQ +++  +  +      +  ++ +      E + 
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551

Query: 7211 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7270
              L ++   W  L+EE  ++ +  +   +  Q Y D ++  A   +Q+       L   +
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQE-------LYMMS 1604

Query: 7271 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7330
             +   D++ A  +   + +L+    V+D    +H+L +  +  V   A S  +S+++S+ 
Sbjct: 1605 EEKAKDEQSAVSMLKKHQILE--QAVEDYAETVHQLSKTSRALV---ADSHPESERISMR 1659

Query: 7331 QHLCALEQALCKQQTSLQAGVLDYE----TFAKSLEALEAWIVEAEEIL----QGQDPSH 7382
            Q       A  K     + G LD         + ++ LE WI E E +      GQD  H
Sbjct: 1660 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1719

Query: 7383 SSDLSTIQERMEELKGQMLKFSSMAPD-----LDRLNELGYRLPLNDKEIKRMQNLNRHW 7437
               ++ +QER  E             D      D L   G+       E K    LN  W
Sbjct: 1720 ---VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWK--DGLNEAW 1774

Query: 7438 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-QRA 7496
            + +      R   L +    H+ + +  E +    +Q + K   E  G  Q+ +E  QR 
Sbjct: 1775 ADLLELIDTRTQILAASYELHKFYHDAKEIFGR--IQDKHKKLPEELGRDQNTVETLQRM 1832

Query: 7497 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR- 7555
            H  F+ ++ +    +  +  D  RL      D  D+   +   +   W+ ++   + RR 
Sbjct: 1833 HTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRV 1892

Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
             ++D+  +   R+  M   L  W+ +V  +        P  +     L +  Q  +    
Sbjct: 1893 RLVDTGDK--FRFFSMVRDLMLWMEDV--IRQIEAQEKPRDVSSVELLMNNHQGIKAEID 1948

Query: 7616 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7675
             +  S+   +E GK LL      +E  ++ +L ++ EK K    + E++ + L  +L+  
Sbjct: 1949 ARNDSFTTCIELGKSLLARKHYASE-EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVH 2007

Query: 7676 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7735
            +            L       S+ +    +E+     R +  E +  +W +  + L  L 
Sbjct: 2008 QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLT 2067

Query: 7736 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7795
                            E +E+ ++Q EE        R++           SE+ +   +W
Sbjct: 2068 TL--------------ELLEVRRQQEEE-------ERKRRPPSPEPSTKVSEEAESQQQW 2106

Query: 7796 LTQMESKVSQNG 7807
             T    +VSQNG
Sbjct: 2107 DTSKGEQVSQNG 2118



 Score =  112 bits (279), Expect = 2e-23
 Identities = 323/1717 (18%), Positives = 664/1717 (38%), Gaps = 220/1717 (12%)

Query: 6472 VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII-----LQKLANVFEQPVAEQIEAI 6526
            +N    ++ + +  I+++ +++KVL  S    K+++     LQK   V E  +  Q E +
Sbjct: 513  MNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLV-EADIGIQAERV 571

Query: 6527 QQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLT 6586
            +      ++F          G K    Q     ++ ++  Y EL  +   RR+ L ++  
Sbjct: 572  RGVNASAQKFATD-----GEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 626

Query: 6587 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY---FQGLESHM-- 6641
            L   +    ++   + E  +   + D    ++S   + +LL KH+ +     G   H   
Sbjct: 627  LWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS---VMRLLSKHRAFEDEMSGRSGHFEQ 683

Query: 6642 -------ILTETLF--RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWS 6692
                   ++ E  F   KI    +    Q+    + Q SA+ K   KR  E   + +  +
Sbjct: 684  AIKEGEDMIAEEHFGSEKIRERIIYIREQWAN--LEQLSAIRK---KRLEEASLLHQFQA 738

Query: 6693 HLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD 6752
              D+    +   L++V SS   VG  E +   L+ +   ++ +   +  Y+P L  + + 
Sbjct: 739  DADDIDAWMLDILKIVSSS--DVGHDEYSTQSLVKK---HKDVAEEIANYRPTLDTLHEQ 793

Query: 6753 GKRLLISISCS-DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6811
               L    + S D+  +L+ + E +     K   EL RL        +   +    ++ +
Sbjct: 794  ASALPQEHAESPDVRGRLSGIEERY-----KEVAELTRLR-------KQALQDTLALYKM 841

Query: 6812 QSAKDRLEFWTQQ------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6865
             S  D  E W  +      ++ +P++LE +    + F     E++ Q+S  + V     Q
Sbjct: 842  FSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 901

Query: 6866 LLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA-ISEVMSWIS 6924
            L+         ++++  +++++W+     +   ++ L  L    + + H   +E  SWI 
Sbjct: 902  LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSALSIQNYHLECNETKSWIR 959

Query: 6925 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 6984
                VI+  +D   +  G  A+   L   +   + I  K         S LQ  ++ +ES
Sbjct: 960  EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKL--------SDLQKEAEKLES 1011

Query: 6985 KRSDKTD-FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 7043
            +  D+      +L  ++  W+ ++  +  +   L G      ++  ++   ++W    + 
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDLDDFQSWLSRTQT 1070

Query: 7044 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7103
             +  +         +  L   +++++ I   E++ +K+   G  + Q + +     +   
Sbjct: 1071 AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQR 1130

Query: 7104 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL---LT 7160
            L+ L   W  L H + + +  L S    +        +  ++L    Y L+   +   L 
Sbjct: 1131 LQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1189

Query: 7161 GSLEAVQVQVDNLQNLQDDLEKQE------RSLQKFGSITNQLLKEC-------HPPVTE 7207
            G+  A++ Q D +  +  + EK        R L   G+I +  ++E        H    E
Sbjct: 1190 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1249

Query: 7208 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL-- 7265
            T +  L  + ++ N  L++  +  Q     L LW   K  + Q  S  + +   +  L  
Sbjct: 1250 TASELL--MRLKDNRDLQKFLQDCQE----LSLWINEKMLTAQDMSYDEARNLHSKWLKH 1303

Query: 7266 ----LKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
                 + A+NK+  D      +Q  ++  +    VK+ L  LH++ E L+      A   
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1363

Query: 7322 IQSDQLSLSQHLCA-LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
              +++  L    CA L++ L   ++ +Q+     + + K L ++   +++ +++L+ Q  
Sbjct: 1364 FDANKAELFTQSCADLDKWLHGLESQIQS-----DDYGKDLTSVNI-LLKKQQMLENQ-- 1415

Query: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-RHWSL 7439
                 +   ++ +EEL+ Q    S      D ++    RL +  K ++ ++ LN R  +L
Sbjct: 1416 -----MEVRKKEIEELQSQAQALSQEGKSTDEVDSK--RLTVQTKFMELLEPLNERKHNL 1468

Query: 7440 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ----R 7495
            ++S+   +F++           +E    W+       +++ +  S ++ H L+      +
Sbjct: 1469 LASKEIHQFNR----------DVEDEILWVG------ERMPLATSTDHGHNLQTVQLLIK 1512

Query: 7496 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7555
             ++  Q E+   Q  +  I    Q ++        +    +L  L   W  +I   ++R 
Sbjct: 1513 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1572

Query: 7556 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7615
              ++   R  Q Y + AE    W+ E     MS         ++A+     V   +K  +
Sbjct: 1573 RRLEEAHRAQQYYFDAAEA-EAWMSEQELYMMSE--------EKAKDEQSAVSMLKKHQI 1623

Query: 7616 RQQG--SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 7673
             +Q    Y  TV       LS  S      +A +A+   + +  SMR + +  KL   LK
Sbjct: 1624 LEQAVEDYAETVHQ-----LSKTS------RALVADSHPESERISMR-QSKVDKLYAGLK 1671

Query: 7674 DWEKCEKGIADSLEKLRTFKKKL---------------SQSLPDHHEELHAEQMRCKELE 7718
            D  +  +G  D   +L    +++               S  L   +E +   Q R +E  
Sbjct: 1672 DLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA 1731

Query: 7719 NAVGSWTDD-LTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGE 7777
               G+   + +  ++ L D L       D + + E  + L   W +L   +  R Q +  
Sbjct: 1732 RDTGNIGQERVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAA 1790

Query: 7778 RLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIAIAQENKIQ 7835
               E   F    KE+   +     K+ +    D    E ++++   ++ +I        Q
Sbjct: 1791 SY-ELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQ 1849

Query: 7836 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7895
            LQ+   RL  A    KA +I+ +  +V + W+ LLD   +R  +L +T    +     + 
Sbjct: 1850 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VR 1908

Query: 7896 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7955
             L  W+  +  ++         +S E+   +N  Q ++ +I+  +    + + L + LL 
Sbjct: 1909 DLMLWMEDVIRQIEAQEKPRDVSSVEL--LMNNHQGIKAEIDARNDSFTTCIELGKSLL- 1965

Query: 7956 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW-------QKFLDDY 8008
                            A+  +  +   +     E   K E+ W  W        +F  D 
Sbjct: 1966 -----------ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WLRLILEVHQFSRDA 2013

Query: 8009 SRFEDWLKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVH---------ECLTQLE 8057
            S  E WL   E    + SS  +  +V + E  +K+ EAF++            E LT LE
Sbjct: 2014 SVAEAWLLGQE---PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070

Query: 8058 L--INKQYRRLARENRTDSACSLKQMVH--EGNQRWD 8090
            L  + +Q     R+ R  S     ++    E  Q+WD
Sbjct: 2071 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWD 2107



 Score = 99.8 bits (247), Expect = 1e-19
 Identities = 334/1812 (18%), Positives = 714/1812 (39%), Gaps = 232/1812 (12%)

Query: 3684 SRYQALLLQVLEQIKFLEEEIQS---LEESESSLSSYSDWYGST-----HKNFKNVATKI 3735
            S+ +AL ++     K L+  I++   +E+ ES  S   +W   T     ++ F N    +
Sbjct: 265  SKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGV 324

Query: 3736 DKVDTVMMGKKLKTLEVLLKDMEKGHS-----LLKSAREKGERAVKYLEEGEA------- 3783
             +   +      +T+E   K  EKG+       ++S      + V    EG+        
Sbjct: 325  QQ--QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKA 382

Query: 3784 -ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
             ERL K  H+     +EL   +R E +  EK   LA+ F  K      W++E Q ++   
Sbjct: 383  WERLEKAEHE-----RELA--LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-Q 434

Query: 3843 EEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV----RE-KGEALLELVQDVTLKDKID 3897
            +    +L   +A   K+++++  + ++E  V++V    RE + E   ++ +    KD + 
Sbjct: 435  DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVI 494

Query: 3898 QLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLE 3957
            +L            E++  L    +   + N  LQ++ + +L +       D ++   + 
Sbjct: 495  RLW-----------EYLLELLRARRQRLEMNLGLQKIFQEMLYIM------DWMDEMKVL 537

Query: 3958 TITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQ------ 4011
             ++Q    H      + G ED L        TL+ +    +QA+  + V+A  Q      
Sbjct: 538  VLSQDYGKH------LLGVEDLLQK-----HTLV-EADIGIQAERVRGVNASAQKFATDG 585

Query: 4012 -GTKDSYSAICSTAQRMYQSLEHEL-QKHVSRQDTLQQCQA-----WLSAVQPDLEPSPQ 4064
             G K     +        +    EL Q    R+  L++ +      W  A +       +
Sbjct: 586  EGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKE 645

Query: 4065 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE---QTIEQK 4121
              LS  +  K +     L  + R + D +         ++K     I +     + I ++
Sbjct: 646  KILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRER 705

Query: 4122 LVQAQNLTQGWEEIKHLKSE-------LWIYLQDAD----------QQLQNMKRRHSELE 4164
            ++  +      E++  ++ +       L  +  DAD          + + +    H E  
Sbjct: 706  IIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYS 765

Query: 4165 LNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKE-ESPEHK-EINHLNDQWLDLC 4222
                Q++V + KD  +++ + + +++T+ E+ + L ++  ESP+ +  ++ + +++ ++ 
Sbjct: 766  ---TQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVA 822

Query: 4223 RQSNNLCLQREEDLQRTRDYHDCMN---VVEVFLEKFTTEWDNLAR-----SDAESTAVH 4274
                 L   R++ LQ T   +   +     E+++++   +W N  +      D E     
Sbjct: 823  E----LTRLRKQALQDTLALYKMFSEADACELWIDE-KEQWLNNMQIPEKLEDLEVIQHR 877

Query: 4275 LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR 4334
             E+L+   +  Q  + A+ +   Q  + + H     ++ +K Q   L  RW Q  +L+ R
Sbjct: 878  FESLEP-EMNNQASRVAVVN---QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR 933

Query: 4335 KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE- 4393
            K    ++ L   N       E   W  E+   I     Q    D+A  + +       E 
Sbjct: 934  KKDALLSALSIQNY-HLECNETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMER 990

Query: 4394 -LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKAL 4452
             L A +  L  L K+A+++ ++   ++ Q I   L++       +   +  R   L +A 
Sbjct: 991  DLVAIEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEISDVWEEMKTTLKNREASLGEA- 1048

Query: 4453 SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTG 4512
            S+  QFL  +    S + + +  I   +    L +   K +   ++ +  +  Y+ +   
Sbjct: 1049 SKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTE-AEKLLTQHENIKNEIDNYEEDYQK 1107

Query: 4513 LWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH----FK 4568
            +   G  + +  T+ +   +  +LQ L + ++ +     H++ E  +NL+S+ H    F 
Sbjct: 1108 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-----HKMWENRQNLLSQSHAYQQFL 1162

Query: 4569 EDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4627
             D  +A  +L   + ++   E+    E +E    + K ++ +      E  +  +  TG+
Sbjct: 1163 RDTKQAEAFLNNQEYVLAHTEMPTTLEGAE--AAIKKQEDFMTTMDANEEKINAVVETGR 1220

Query: 4628 TILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSL 4687
             ++   N ++   + EK++++  +          K  +    +L R +    ++   Q  
Sbjct: 1221 RLVSDGN-INSDRIQEKVDSIDDRHR--------KNRETASELLMRLKDNRDLQKFLQDC 1271

Query: 4688 SELEAQFLRMSKVPTDLAVEEALSLQDGC---RAILDEVAGLGEAVDELNQKKEGFRSTG 4744
             EL            D++ +EA +L       +A + E+A   E +D++  +KEG +   
Sbjct: 1272 QELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI--EKEGMQLIS 1329

Query: 4745 QPWQPD-----KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKE 4799
            +  + +     K+  L  ++  L+  T+ +   L D   A +   + C  L++ L  ++ 
Sbjct: 1330 EKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLES 1388

Query: 4800 E--QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE-KARH 4856
            +       ++       LK    L   ++    V K+    +E+L      L+ E K+  
Sbjct: 1389 QIQSDDYGKDLTSVNILLKKQQMLENQME----VRKK---EIEELQSQAQALSQEGKSTD 1441

Query: 4857 QIQSWQGELKLLTSAIGETVTECESRMVQSID---FQTEMSRSLDWLRRVKAELSGPVYL 4913
            ++ S +  ++     + E + E +  ++ S +   F  ++   + W+   +  L+     
Sbjct: 1442 EVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGE-RMPLATSTDH 1500

Query: 4914 DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL 4973
              NLQ +Q  I+K Q  Q+E+Q     ++ +  + +   T +  L +  +   LA+L +L
Sbjct: 1501 GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQL 1560

Query: 4974 DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLK 5033
             G + E    R   L E + + Q+YY     A  W+ + +  +       D +SA   LK
Sbjct: 1561 WGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLK 1619

Query: 5034 SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED-----LEQKVASLELRSQRMSRD 5088
             H      E       E +H L  T   L+  +  E       + KV  L    + ++ +
Sbjct: 1620 KHQ---ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEE 1676

Query: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKAL 5148
               ++D   R       +Q  RE     ++D E+ ++E  ++  + SHE  +   EH  +
Sbjct: 1677 RRGKLDERHRL------FQLNRE-----VDDLEQWIAEREVV--AGSHELGQDY-EHVTM 1722

Query: 5149 V---------SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA 5199
            +            N   E++  +   A +L  +G+ +  AT++     + + W  L  + 
Sbjct: 1723 LQERFREFARDTGNIGQERVDTVNHLADELINSGH-SDAATIAEWKDGLNEAWADLLELI 1781

Query: 5200 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259
              + +IL  A  E   F +  K+    I     KLP       +  E  TL   H TF  
Sbjct: 1782 DTRTQILA-ASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVE--TLQRMHTTFEH 1838

Query: 5260 ELEQQQSALGMLRQQTLSMLQ-----DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTN 5314
            +++   + +  L Q+  + LQ     D A      E  +++   ++ D C + + ++   
Sbjct: 1839 DIQALGTQVRQL-QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDT 1897

Query: 5315 GKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-ATNHRQN 5373
            G        D+    + +  +  W+++          +I+AQ +   +   E   N+ Q 
Sbjct: 1898 G--------DKFRFFSMVRDLMLWMEDVIR-------QIEAQEKPRDVSSVELLMNNHQG 1942

Query: 5374 IEKMAEEQKEKY 5385
            I+   + + + +
Sbjct: 1943 IKAEIDARNDSF 1954



 Score = 96.7 bits (239), Expect = 9e-19
 Identities = 320/1743 (18%), Positives = 671/1743 (38%), Gaps = 239/1743 (13%)

Query: 3481 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ------YSVLEGDAHTHETTLRD 3534
            +  + + EKL +L + + R     E WL + Q  + Q         +E     HE    D
Sbjct: 398  RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETD 457

Query: 3535 L----QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3590
            +    + +Q   A  + L     H   D+    I   +D  +      W+ Y   L   R
Sbjct: 458  IAAYEERVQAVVAVARELEAENYH---DI--KRITARKDNVIRL----WE-YLLELLRAR 507

Query: 3591 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKE-IQLHQMKKWHEEVT 3649
             Q   +   L+ + Q+   + +W+   +  V  +   +     ++ +Q H + +   ++ 
Sbjct: 508  RQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVE--ADIG 565

Query: 3650 AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEE 3709
               + V  V A AQ+   +        C    +  R   +     E  +   E    LEE
Sbjct: 566  IQAERVRGVNASAQKFATDG--EGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEE 623

Query: 3710 SESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSARE 3769
            S      +  W  +  + +     KI   D    GK L ++  LL         +     
Sbjct: 624  SRRLWKFF--WEMAEEEGWIREKEKILSSDD--YGKDLTSVMRLLSKHRAFEDEMSGRSG 679

Query: 3770 KGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
              E+A+K     E E +  E H   E+++E    +R++   LE+   + K+  ++   L 
Sbjct: 680  HFEQAIK-----EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLH 734

Query: 3830 QWIAEYQEI---------LHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
            Q+ A+  +I         +    +   + Y  ++ + K+K + + + ++ P++ ++ E+ 
Sbjct: 735  QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA 794

Query: 3881 EAL-LELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSE------LQE 3933
             AL  E  +   ++ ++  ++  Y+++  + +    +L+  +  ++ ++        + E
Sbjct: 795  SALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDE 854

Query: 3934 VEKWL--LQMSGRL------------VAPDLLETSS----LETITQQLAHHKAMME-EIA 3974
             E+WL  +Q+  +L            + P++   +S    +  I +QL H     E EI 
Sbjct: 855  KEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIK 914

Query: 3975 GFEDRLNNLQMKGDTLIGQCADHLQAKLK-QNVHAHLQGTK----DSYSAICST------ 4023
              +D+LN    +   L+ +  D L + L  QN H     TK    +    I ST      
Sbjct: 915  AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGND 974

Query: 4024 ------AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV- 4076
                   QR    +E +L    ++   LQ+    L +  PD     Q  LSR   I  V 
Sbjct: 975  LAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPD---QAQAILSRLAEISDVW 1031

Query: 4077 -------KHFRALQEQARTYLDLLCSMCD----LSNASVKTTAKDIQQTEQTIEQKLVQA 4125
                   K+  A   +A      L  + D    LS       ++D+  T    E+ L Q 
Sbjct: 1032 EEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQH 1091

Query: 4126 QNL---------------------TQG--------------------------WEEIKHL 4138
            +N+                     TQG                          WE  ++L
Sbjct: 1092 ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNL 1151

Query: 4139 KSELWIYLQ------DADQQLQNMK--RRHSELELNI--AQNMVSQVKDFVKKLQSKQAS 4188
             S+   Y Q       A+  L N +    H+E+   +  A+  + + +DF+  + + +  
Sbjct: 1152 LSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEK 1211

Query: 4189 VNTIIEKVNKLTKK---EESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDC 4245
            +N ++E   +L            ++++ ++D+       ++ L ++ +++    +   DC
Sbjct: 1212 INAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDC 1271

Query: 4246 MNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLAL--ALQERKYAIEDLKDQKQKMI 4303
              +     EK  T  D    S  E+  +H + LK  A    L   K  ++ ++ +  ++I
Sbjct: 1272 QELSLWINEKMLTAQD---MSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI 1328

Query: 4304 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4363
                 + + +VKE+ + L + W  LE   + K Q  + +  +  +      +L +W    
Sbjct: 1329 SE-KPETEAVVKEKLTGLHKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGL 1386

Query: 4364 QPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVI 4423
            +  I ++            LL     + +++E ++  ++ L   A + ++  G +  +V 
Sbjct: 1387 ESQI-QSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDEVD 1444

Query: 4424 QKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHIC 4483
             K L+     +  L  L    RK+   A  E  QF   V      + +        +H  
Sbjct: 1445 SKRLTVQTKFMELLEPL--NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1502

Query: 4484 LLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVY 4543
             L   V   +K  ++ Q  ++ +Q  +  ++ + + ++ + +      +  +L +L+ ++
Sbjct: 1503 NL-QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLW 1561

Query: 4544 DSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLA 4603
              ++++   R + LE+   +++++  D  +A  W+ + ++    E    +E S + + L 
Sbjct: 1562 GLLIEETEKRHRRLEEAHRAQQYY-FDAAEAEAWMSEQELYMMSEEKAKDEQSAV-SMLK 1619

Query: 4604 KYQNILEQSPE-YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
            K+Q ILEQ+ E Y   +  L +T + ++   +  +   +S + + + + +  +  LA+++
Sbjct: 1620 KHQ-ILEQAVEDYAETVHQLSKTSRALVAD-SHPESERISMRQSKVDKLYAGLKDLAEER 1677

Query: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAV----EEALSLQDGCRA 4718
              K+ E          L +L  + + +LE        V     +    E    LQ+  R 
Sbjct: 1678 RGKLDER-------HRLFQL-NREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFRE 1729

Query: 4719 ILDEVAGLG-EAVDELNQKKEGFRSTGQ-------PWQPDKMLHLVTLYHRLKRQTEQRV 4770
               +   +G E VD +N   +   ++G         W+         L   +  +T Q +
Sbjct: 1730 FARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT-QIL 1788

Query: 4771 SLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGI 4830
            +   +    Y + +++  +++ + K + EE   +  +    E   +M+ +    +Q  G 
Sbjct: 1789 AASYELHKFYHDAKEIFGRIQDKHKKLPEE---LGRDQNTVETLQRMHTTFEHDIQALGT 1845

Query: 4831 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4890
             ++++    ED A      A +KA   IQ  + E   +  A    +  CESR V+ +D  
Sbjct: 1846 QVRQLQ---EDAARLQAAYAGDKA-DDIQKRENE---VLEAWKSLLDACESRRVRLVDTG 1898

Query: 4891 TE-----MSRSL-----DWLRRVKA-----ELSGPVYLDLNLQDIQEEIRKIQIHQEEVQ 4935
             +     M R L     D +R+++A     ++S    L  N Q I+ E   I    +   
Sbjct: 1899 DKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAE---IDARNDSFT 1955

Query: 4936 SSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQC 4995
            + + +  +L  +        K   S +++  L +L+E   ++ +    R   L  +  + 
Sbjct: 1956 TCIELGKSLLAR--------KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWL-RLILEV 2006

Query: 4996 QRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF---FSTEDQFHSNLEEL 5052
             ++ +    A  WL   +  L     G  V+  E+ +K H  F    +T D+  S LE L
Sbjct: 2007 HQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERL 2066

Query: 5053 HSL 5055
             +L
Sbjct: 2067 TTL 2069



 Score = 95.1 bits (235), Expect = 3e-18
 Identities = 249/1456 (17%), Positives = 575/1456 (39%), Gaps = 166/1456 (11%)

Query: 1258 QAEKILDTEN----LFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR--GH 1311
            + EKIL +++    L    +LL  H+     +S +    +Q I   ++GE  + +   G 
Sbjct: 643  EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAI---KEGEDMIAEEHFGS 699

Query: 1312 EELRK----LESTLDGLERSRERQERRIQVTLRKWERFETNKETV-------VRYLFQTG 1360
            E++R+    +      LE+    +++R++       +F+ + + +       ++ +  + 
Sbjct: 700  EKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSD 758

Query: 1361 SSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQA 1420
              H+ + + S ++      E+   +    +++  QA  L +E +E P        ++++ 
Sbjct: 759  VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERY 818

Query: 1421 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1480
            K + E  +  +  L++ +   +M         S  +   +WI EKE+ LN ++      D
Sbjct: 819  KEVAELTRLRKQALQDTLALYKMF--------SEADACELWIDEKEQWLNNMQIPEKLED 870

Query: 1481 MQISQIKVTIQEIE--SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELRE 1538
            +++ Q +    E E  ++ S +  + + A+         E   IKA+  ++     + RE
Sbjct: 871  LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEK-EIKAQQDKLNTRWSQFRE 929

Query: 1539 HAQCLEGTILGHLSQQQKFEE--------------------------NLRKIQQSVSEFE 1572
                 +  +L  LS Q    E                           +  +Q+ ++  E
Sbjct: 930  LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGME 989

Query: 1573 -DKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAIT-AFSASARKVVNRDSCVQEAA 1630
             D +A+  K+     E  K+  EH D  QA+ S  + I+  +      + NR++ + EA+
Sbjct: 990  RDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS 1049

Query: 1631 ALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRV 1690
             LQQ   D                         L  F +WL R +   +S +M  +    
Sbjct: 1050 KLQQFLRD-------------------------LDDFQSWLSRTQTAIASEDMPNTL--T 1082

Query: 1691 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1750
            + E  L   + ++NE+ +    Y K+  + E +    +      ++  L+ LD  W +L 
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH 1142

Query: 1751 QIINKRINFLQSVVAEHQQF------DELLLSFSVWIKLFLSELQTTSEISIMDHQVALT 1804
            ++   R N L    A +QQF       E  L+   ++ L  +E+ TT E      + A+ 
Sbjct: 1143 KMWENRQNLLSQSHA-YQQFLRDTKQAEAFLNNQEYV-LAHTEMPTTLE----GAEAAIK 1196

Query: 1805 RHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ--GKAEDCFQLFEEASQVVER 1862
            + +D    +++ + ++ ++     +L S G      + +     +D  +   E +  +  
Sbjct: 1197 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1256

Query: 1863 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESA 1922
            R      L +FLQ    LS  + +   T +    M+ +E+    ++L+      +A  + 
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQ---DMSYDEA----RNLHSKWLKHQAFMAE 1309

Query: 1923 AVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKA 1982
              S    L K +       SE+  +     ++L G  +  + L  T Q++A  L    KA
Sbjct: 1310 LASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA 1369

Query: 1983 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2040
              F     +L K +  +E +   +   +    ++   L+    LE+++   + E+  L+ 
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQS 1428

Query: 2041 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2100
            +A+ ++Q+  +   EVD +   ++  + +    ++E +       ++ +  ++++  +  
Sbjct: 1429 QAQALSQEGKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW 1487

Query: 2101 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
            V E       T     + + ++    K++T + ++   Q  +D+   + ++++++   + 
Sbjct: 1488 VGERMPLATSTDHG-HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1546

Query: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
            +        D++      ++ +EK    ++    +   + D      E E W        
Sbjct: 1547 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA----EAEAW-------- 1594

Query: 2221 AENISNLDNHLRAEELLKEFESEV----KNKALR--LEELHSKVNDLKELTKNL--ETPP 2272
               +S  + ++ +EE  K+ +S V    K++ L   +E+    V+ L + ++ L  ++ P
Sbjct: 1595 ---MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1651

Query: 2273 DLQFI---EADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2329
            + + I   ++ + +     K++ E  +G L D   +  Q+ + ++D+  W  + E    +
Sbjct: 1652 ESERISMRQSKVDKLYAGLKDLAEERRGKL-DERHRLFQLNREVDDLEQWIAEREVVAGS 1710

Query: 2330 CAQNETCEALKKVKDIQKELQSQQSNISSTQ-ENLNSLCRKYHS---AELESLGRAMTGL 2385
                +  E +  +++  +E      NI   + + +N L  +  +   ++  ++     GL
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770

Query: 2386 IKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG-DSKVLEA 2444
             +    + +L       L  S E H  +   + +E F   +   K+  +  G D   +E 
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELH--KFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET 1828

Query: 2445 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCL 2504
                       +    +++  + ++   L A  +      IQ++  +  E +++ L  C 
Sbjct: 1829 LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1888

Query: 2505 KDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFL 2564
              +  L D   +   F    R L LW+ ++  +   +          EK  +V  VE+ +
Sbjct: 1889 SRRVRLVDTGDKF-RFFSMVRDLMLWMEDVIRQIEAQ----------EKPRDVSSVELLM 1937

Query: 2565 -------GELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLCSQLLTSHQNLLRMTKEKL 2616
                    E+ A  +S     + G+ L    H A +E      QL    + ++   +++ 
Sbjct: 1938 NNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRW 1997

Query: 2617 RSCQVALQEHEALEEA 2632
               ++ L+ H+   +A
Sbjct: 1998 EWLRLILEVHQFSRDA 2013



 Score = 89.0 bits (219), Expect = 2e-16
 Identities = 328/1871 (17%), Positives = 701/1871 (37%), Gaps = 223/1871 (11%)

Query: 4934 VQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYS 4993
            +QS +R  N     +K    +  +LIS D+  +   L + + + + ALR       ++  
Sbjct: 356  IQSKMRANN-----QKVYMPREGKLIS-DINKAWERLEKAEHERELALRNELIRQEKLEQ 409

Query: 4994 QCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELH 5053
              +R+ +       WL + Q L+     G D+ + E   K H    +    +   ++ + 
Sbjct: 410  LARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVV 469

Query: 5054 SLVATLD-----PLIKPTGKED-----LEQKVASLELRSQRMSRDSGAQVDLLQRC-TAQ 5102
            ++   L+      + + T ++D      E  +  L  R QR+  + G Q    +      
Sbjct: 470  AVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMD 529

Query: 5103 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5162
            W D  K    V+ L  D  K L              E+ L +H  + + +    E++  +
Sbjct: 530  WMDEMK----VLVLSQDYGKHLL-----------GVEDLLQKHTLVEADIGIQAERVRGV 574

Query: 5163 EEKASQLEKTG---NDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5219
               A +    G          +   +  +   +  L  +A ++   LE++   W  F   
Sbjct: 575  NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634

Query: 5220 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML 5279
             ++  E   + ++K+  S         ++ LL  H  F    E + S      +Q +   
Sbjct: 635  AEE--EGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF----EDEMSGRSGHFEQAIKEG 688

Query: 5280 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5339
            +D  A        + + I  ++++  N+ E++    K   +E       +   + +  W+
Sbjct: 689  EDMIAEEHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADADDIDAWM 747

Query: 5340 QE-----TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5394
             +     +   +G+      + +++ + +  E  N+R  ++ + E+         + LP 
Sbjct: 748  LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA--------SALPQ 799

Query: 5395 E-------------LSLQLAEVALDLKIRDQ-IQDKIKEVEQ-SKATSQELSRQIQKLAK 5439
            E             +  +  EVA   ++R Q +QD +   +  S+A + EL   I +  +
Sbjct: 800  EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACEL--WIDEKEQ 857

Query: 5440 DLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAK 5499
             L  +    K +   V+Q + +   L  E++   S++  ++   ++ +       K +  
Sbjct: 858  WLNNMQIPEKLEDLEVIQHRFES--LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915

Query: 5500 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTIAWNS 5558
            +  KL     Q  R+  +R      +A  ++ Y+        WI EK KV+       N 
Sbjct: 916  QQDKLNTRWSQ-FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGND 974

Query: 5559 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS--QQVAELGRETEEL 5616
             + +         +  +   I+++L  + ++ + L S +  +  +   ++AE+    EE+
Sbjct: 975  LAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEM 1034

Query: 5617 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 5676
            +  +K R  +L +A+K +++F  +L   Q+ L + Q  + S +     +   L+  + LL
Sbjct: 1035 KTTLKNREASLGEASK-LQQFLRDLDDFQSWLSRTQTAIASED-----MPNTLTEAEKLL 1088

Query: 5677 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQ------HTAIQQC 5730
            ++ E++K ++   +     +R   ++V         + L++    L       H   +  
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR 1148

Query: 5731 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG 5790
              + +    Y+Q+ ++ K  +  +      +    + T+ ++  +A I + E+    +  
Sbjct: 1149 QNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT-LEGAEAAIKKQEDFMTTMDA 1207

Query: 5791 YQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA 5850
             +E+I ++    + L          +    ++   +  +D   +   T S          
Sbjct: 1208 NEEKINAVVETGRRLVSDGN-----INSDRIQEKVDSIDDRHRKNRETAS---------- 1252

Query: 5851 GRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910
                 LL  + +    +    +      C+  S   N      QD++Y +A +       
Sbjct: 1253 ----ELLMRLKDNRDLQKFLQD------CQELSLWINEKMLTAQDMSYDEARNLHSKWLK 1302

Query: 5911 AAKIHPSTSASQEFYE-------------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5957
                    ++++E+ +             P  E     KL  L + WE L++    K + 
Sbjct: 1303 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQR 1362

Query: 5958 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGR---SPESQMAEHQALMDEILMLQ 6014
            L++A  + + +  S   +   +  +E ++ +S + G+   S    + + Q L +++ + +
Sbjct: 1363 LFDA-NKAELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNILLKKQQMLENQMEVRK 1420

Query: 6015 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6074
             EI ELQS  A+ L  E    D  +       LTV  + M  +      K  LL  K   
Sbjct: 1421 KEIEELQSQ-AQALSQEGKSTDEVD----SKRLTVQTKFMELLEPLNERKHNLLASKEIH 1475

Query: 6075 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6134
            Q     +++ L            W +  +  L T+         ++  +   Q +  EI+
Sbjct: 1476 QFNRDVEDEIL------------W-VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1522

Query: 6135 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 6194
                 + ++   ++N++ +  + + +   Q    L++L G L+E     H ++L     A
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH-RRLEEAHRA 1581

Query: 6195 QEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASR 6254
            Q+      +  A  S      +++ +    Q   S L++ + LEQ + +    +  ++  
Sbjct: 1582 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1641

Query: 6255 GEEILI-QHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLL 6313
               ++   H  +E       K D L       G K  AE++ R K +  H+ F   +++ 
Sbjct: 1642 SRALVADSHPESERISMRQSKVDKL-----YAGLKDLAEER-RGKLDERHRLFQLNREV- 1694

Query: 6314 QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6373
                  + EQ +  R   +++G          QD   VT     L + F E +  +G   
Sbjct: 1695 -----DDLEQWIAER--EVVAG-----SHELGQDYEHVTM----LQERFREFARDTGNIG 1738

Query: 6374 RQSI----HLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 6429
            ++ +    HL  +L +   + +  + + ++ L  A A L E  +T     +ILA      
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDT---RTQILA-----A 1790

Query: 6430 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF 6489
            S E+ K  +   + F    D    + + LG     +  L  +     H ++    Q+   
Sbjct: 1791 SYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1850

Query: 6490 QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK 6549
            Q D   L  + A +K   +QK  N          E ++  +  L   ++  + L   GDK
Sbjct: 1851 QEDAARLQAAYAGDKADDIQKREN----------EVLEAWKSLLDACESRRVRLVDTGDK 1900

Query: 6550 LQVEQPSMQELSKLQDMY-----DELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 6604
             +        +  ++D+       E    + S    +N +  +K++ +         +E 
Sbjct: 1901 FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIEL 1960

Query: 6605 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES-----HMILTETLFRKIISFA---- 6655
            G+  +A         KE++ QL +K KE     E       +IL    F +  S A    
Sbjct: 1961 GKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWL 2020

Query: 6656 VQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR--QLEVVESSIP 6713
            + +E    +  + Q+   +++  KR    E    TW   DE    L R   LE++E    
Sbjct: 2021 LGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATW---DERFSALERLTTLELLE---- 2073

Query: 6714 SVGLVEENEDR 6724
             V   +E E+R
Sbjct: 2074 -VRRQQEEEER 2083



 Score = 86.3 bits (212), Expect = 1e-15
 Identities = 187/959 (19%), Positives = 387/959 (40%), Gaps = 112/959 (11%)

Query: 4889 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRIMNALSHK 4947
            F  EM+    W+R  +  LS   Y   +L  +   + K +  ++E+   S     A+  K
Sbjct: 630  FFWEMAEEEGWIREKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAI--K 686

Query: 4948 EKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAAND 5007
            E E     +   S  +   +  + E   ++++    R+  L E     Q     FQA  D
Sbjct: 687  EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ-----FQADAD 741

Query: 5008 ----WLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
                W+ D  +++  +  G D  S +  +K H +       +   L+ LH   + L    
Sbjct: 742  DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-- 799

Query: 5064 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIEL-MNDTEK 5122
            +     D+  +++ +E R + ++  +  +   LQ   A +  + +A  +  EL +++ E+
Sbjct: 800  EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA--DACELWIDEKEQ 857

Query: 5123 KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLS 5182
             L+   + +     E  +   E  +L   +N+   ++  + + A QL  +G+ + K  + 
Sbjct: 858  WLNNMQIPEKLEDLEVIQHRFE--SLEPEMNNQASRVAVVNQIARQLMHSGHPSEKE-IK 914

Query: 5183 RSMTTVWQRWTRLRAVAQDQEKILEDAVD------EWTGFNNKVKKATEMIDQLQDKLPG 5236
                 +  RW++ R +   ++  L  A+       E     + +++ T++I+  QD L  
Sbjct: 915  AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD-LGN 973

Query: 5237 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
              A   +    LT +E  D   +E +             LS LQ  A     E P   Q 
Sbjct: 974  DLAGVMALQRKLTGME-RDLVAIEAK-------------LSDLQKEAEKLESEHPDQAQA 1019

Query: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET---QINSVKCWVQETKEYLGNPTIEI 5353
            I +      ++ E++KT  K  +  L +   ++     ++  + W+  T+  + +   ++
Sbjct: 1020 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DM 1077

Query: 5354 DAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTILPSELSLQLAEVALDLKIRDQ 5412
               L E + LLT+  N +  I+   E+ QK + +G   +   +   Q   +   L+  D 
Sbjct: 1078 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDT 1136

Query: 5413 IQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5472
              +++ ++ +++      S   Q+  +D  T   +        V A T+     E  +  
Sbjct: 1137 GWNELHKMWENRQNLLSQSHAYQQFLRD--TKQAEAFLNNQEYVLAHTEMPTTLEGAEAA 1194

Query: 5473 NSK----LMELDAAVQKF---------LEQNGQLGKP-LAKKIGKLTELHQQTIRQAENR 5518
              K    +  +DA  +K          L  +G +    + +K+  + + H++    A   
Sbjct: 1195 IKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL 1254

Query: 5519 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEE--- 5575
            L +L       +   +  EL L WI + K+L    ++++ A  L  +++ HQ  + E   
Sbjct: 1255 LMRLKDNRDLQKFLQDCQELSL-WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELAS 1312

Query: 5576 SKEIDSELEAMTEKLQYLTSVYCTEKM-SQQVAELGRETEELRQMIKIRLQNLQDAAKDM 5634
            +KE   ++E   E +Q ++    TE +  +++  L +  E L    + + Q L DA K  
Sbjct: 1313 NKEWLDKIEK--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK-A 1369

Query: 5635 KKFEAELKKLQAALEQAQATLTSPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5692
            + F      L   L   ++ + S + G+   S+   L  +Q L ++ME  K +++ +Q  
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ-- 1427

Query: 5693 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH--- 5749
                               A  L +E         ++  + Q   ++  +   E KH   
Sbjct: 1428 -----------------SQAQALSQEGKSTDEVDSKRLTV-QTKFMELLEPLNERKHNLL 1469

Query: 5750 LQQLIEGAHREIEDK--------PVATS-----NIQELQAQISRHEELAQKIKGYQEQI 5795
              + I   +R++ED+        P+ATS     N+Q +Q  I +++ L ++I+G+Q +I
Sbjct: 1470 ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRI 1528


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 299,997,449
Number of Sequences: 37866
Number of extensions: 13047490
Number of successful extensions: 85755
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 1100
Number of HSP's that attempted gapping in prelim test: 46066
Number of HSP's gapped (non-prelim): 21200
length of query: 8797
length of database: 18,247,518
effective HSP length: 128
effective length of query: 8669
effective length of database: 13,400,670
effective search space: 116170408230
effective search space used: 116170408230
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 75 (33.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.