Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 154275767
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
(1762 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 3697 0.0
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 1360 0.0
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 1129 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 330 6e-90
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 309 1e-83
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 292 2e-78
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 286 9e-77
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 279 2e-74
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 275 2e-73
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 275 3e-73
gi|145309328 papilin [Homo sapiens] 265 2e-70
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 257 6e-68
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 248 5e-65
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 248 5e-65
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 248 5e-65
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 243 2e-63
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 233 1e-60
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 230 8e-60
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 218 5e-56
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 214 5e-55
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 213 2e-54
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 213 2e-54
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 202 3e-51
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 193 1e-48
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 179 2e-44
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 177 8e-44
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 167 1e-40
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 159 3e-38
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 156 2e-37
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 154 7e-37
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 3697 bits (9588), Expect = 0.0
Identities = 1762/1762 (100%), Positives = 1762/1762 (100%)
Query: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
Sbjct: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
Query: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
Sbjct: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
Query: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
Sbjct: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
Query: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
Sbjct: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
Query: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
Sbjct: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
Query: 541 GTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFG 600
GTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFG
Sbjct: 541 GTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFG 600
Query: 601 GLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKS 660
GLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKS
Sbjct: 601 GLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKS 660
Query: 661 CNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV 720
CNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV
Sbjct: 661 CNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV 720
Query: 721 QACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQ 780
QACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQ
Sbjct: 721 QACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQ 780
Query: 781 QACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSS 840
QACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSS
Sbjct: 781 QACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSS 840
Query: 841 IRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCP 900
IRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCP
Sbjct: 841 IRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCP 900
Query: 901 ARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKL 960
ARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKL
Sbjct: 901 ARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKL 960
Query: 961 IGGNRKLVARPLSPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSR 1020
IGGNRKLVARPLSPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSR
Sbjct: 961 IGGNRKLVARPLSPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSR 1020
Query: 1021 YDDLVSRLLEQGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDD 1080
YDDLVSRLLEQGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDD
Sbjct: 1021 YDDLVSRLLEQGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDD 1080
Query: 1081 ILGNLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSG 1140
ILGNLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSG
Sbjct: 1081 ILGNLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSG 1140
Query: 1141 FSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLL 1200
FSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLL
Sbjct: 1141 FSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLL 1200
Query: 1201 HCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDS 1260
HCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDS
Sbjct: 1201 HCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDS 1260
Query: 1261 VSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTW 1320
VSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTW
Sbjct: 1261 VSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTW 1320
Query: 1321 FRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQL 1380
FRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQL
Sbjct: 1321 FRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQL 1380
Query: 1381 EDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTA 1440
EDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTA
Sbjct: 1381 EDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTA 1440
Query: 1441 TGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCS 1500
TGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCS
Sbjct: 1441 TGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCS 1500
Query: 1501 ASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRS 1560
ASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRS
Sbjct: 1501 ASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRS 1560
Query: 1561 CGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNG 1620
CGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNG
Sbjct: 1561 CGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNG 1620
Query: 1621 PCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTA 1680
PCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTA
Sbjct: 1621 PCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTA 1680
Query: 1681 TCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKV 1740
TCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKV
Sbjct: 1681 TCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKV 1740
Query: 1741 KQLKLCQLSQFKSRCCGTCGKA 1762
KQLKLCQLSQFKSRCCGTCGKA
Sbjct: 1741 KQLKLCQLSQFKSRCCGTCGKA 1762
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 1360 bits (3521), Expect = 0.0
Identities = 728/1756 (41%), Positives = 982/1756 (55%), Gaps = 149/1756 (8%)
Query: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDC 81
+SR RS+ED+DG WDAWG WS+CSRTCGGGASYSLRRCL+ ++CEG+NIRY+TCSN DC
Sbjct: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDC 123
Query: 82 PPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
PP+A DFRAQQCSA+NDV++ G +YEWLP NDP PC+LKC A+G LVVELAPKVLDG
Sbjct: 124 PPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDG 183
Query: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
TRC T+SLDMCISG+CQ VGCD QLGS KEDNCGVC GDGSTCRLVRGQ KS +S K
Sbjct: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
Query: 202 DDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPD 261
++ V+A+P GSR +R+ +KGP HL++E+KTLQG+KGE+S +S G FLV+N++V+FQ+ +
Sbjct: 244 EENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSE 303
Query: 262 KEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTS 321
++ ++ GPL ADFI K R + + DS VQF FYQPI H+WR+TDFFPC+ TCGGGYQL S
Sbjct: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNS 363
Query: 322 AECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWE 381
AEC D+R RVV D YCHYYPEN+KPKPKL+EC++DPCP+SDG+K+IMPYD + PLPRWE
Sbjct: 364 AECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWE 423
Query: 382 ATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWL 441
PWTACS SCGGGIQ R+ CVEE + G + VEEWKCMY PK + Q CN+FDCPKW+
Sbjct: 424 HNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWI 483
Query: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
A EWS CTVTCG+GLRYRVVLCI+HRG H GGC+P+ K HIKEEC++P PCYKPKEK PV
Sbjct: 484 AMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPV 543
Query: 502 EAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVAD 561
EAKLPW KQAQELEE +EEP+FIPE WSAC+ TCG G QVR V+C+VLL+F+Q+ +
Sbjct: 544 EAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETE 603
Query: 562 LPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSE 621
LP +ECEGPK ++R C C + +P + +D + YDWEY GFT C+
Sbjct: 604 LPEEECEGPKLPTERPCLLEAC-----DESPASRELDIPLPEDSETTYDWEYAGFTPCTA 658
Query: 622 SCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLT 681
+C GG QEA+ CL+ QT++ ++LC RPP + ++CN +PCP RW +G W PCS T
Sbjct: 659 TCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSAT 718
Query: 682 CGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCS 741
CGVG+QTRDV+C H ET +E CR KP +QACN+F+CPP W+ +WQ CS
Sbjct: 719 CGVGIQTRDVYCLH-----PGETPAPPEE-CRDEKPHALQACNQFDCPPGWHIEEWQQCS 772
Query: 742 RTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECS 801
RTCGGG Q R V C+Q + DGSFL L + C K + ++C + DCP + DW++CS
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
Query: 802 TSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR-PGRPSTK-- 858
SCG G Q R +C+++ G ++ +C LP +R C + C++ TK
Sbjct: 833 VSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLG 892
Query: 859 -HSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCPARRVRKPLITWEKDGQH 917
P I + ++VYIQTR +++++ +G AYLLP T+V+++CP RR +K LI WEKDG+
Sbjct: 893 EQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRC 952
Query: 918 LISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKLIGGNRKLVARPLSPRSE 977
L +S + + G LKIH L D GVY C AG A+E V+KLIG + +L+ARP
Sbjct: 953 LQNSKRLGITKSGSLKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARP------ 1006
Query: 978 EEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSRYDDLVSRLLEQGGWPGE 1037
A R+ + H N + K + N DD +S G
Sbjct: 1007 ----ALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFLRALLGH 1062
Query: 1038 LLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDDILGNLSQQPE--ELRDL 1095
+ + N+ ++ E + ++M T Q D+++ N+SQ E E+ D
Sbjct: 1063 C-----SNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQ--FDELIRNMSQLMETGEVSDD 1115
Query: 1096 YSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSGFSSSLRTSSTGDAGG 1155
+ L+ QL E+ ++ H + R P + G + S+ SS G
Sbjct: 1116 LASQLIYQLVAELAKAQPTHM-------QWRGIQEETPPAAQLRGETGSVSQSSHAKNSG 1168
Query: 1156 GSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRPTISWA 1215
+ P ++R+ + + +G TV + T + + C+ I T +W
Sbjct: 1169 KLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWT 1228
Query: 1216 RNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKT 1275
++G +Q S +I+L +QI P + G Y C+ N LG D S +V A P++ +
Sbjct: 1229 KDGTLLQPSVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILS 1288
Query: 1276 SRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTWFRNKSKL-GSPHHLH 1334
+ E ++V +G ++ G NVTI C V GVP+ +TW + L G+ L
Sbjct: 1289 VERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGNVSLLF 1348
Query: 1335 EGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQLEDIRA----LLAAT 1390
GSLLL NVS ++G Y C A N G+ ++ L +L+ +++ ++ +L AT
Sbjct: 1349 NGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQAT 1408
Query: 1391 G--PNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHIL 1448
N P + +PGN W H + H+
Sbjct: 1409 NTRTNSNDPTGEPPPQEPFWEPGN-----------------WSH-------CSATCGHLG 1444
Query: 1449 AAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCG---- 1504
A Q Q +G E C + + ++ W + CS SCG
Sbjct: 1445 ARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYH 1504
Query: 1505 NRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGG 1564
+R V R + V+P CA K RP R+ C V W R C G
Sbjct: 1505 SRQVTCKRTKANGTVQVVSPRACAPKDRP------LGRKPCFGHPCV-QWEPGNR-CPGR 1556
Query: 1565 VQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC-VEWAFSSWGQCNGPCI 1623
R V Q+ + S+D KRP + C C V W W C C
Sbjct: 1557 CMGRAVRMQQRHTA--CQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAAC- 1613
Query: 1624 GPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCG 1683
Q R+V C + + C +PV+ ++C + + WR L C C
Sbjct: 1614 --GRGFQSRKVDC-------IHTRSC----KPVAKRHCVQKKKPISWRHCLGPSCDRDC- 1659
Query: 1684 NYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKVKQL 1743
DTT YC VK L
Sbjct: 1660 -----------------------------------------------TDTTHYCMFVKHL 1672
Query: 1744 KLCQLSQFKSRCCGTC 1759
LC L ++K RCC +C
Sbjct: 1673 NLCSLDRYKQRCCQSC 1688
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 1129 bits (2919), Expect = 0.0
Identities = 525/525 (100%), Positives = 525/525 (100%)
Query: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
Sbjct: 1 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC 60
Query: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
Sbjct: 61 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS 120
Query: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
Sbjct: 121 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG 180
Query: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
Sbjct: 181 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS 240
Query: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
Sbjct: 241 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR 300
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP 480
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS 525
HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPS 525
Score = 101 bits (251), Expect = 7e-21
Identities = 56/170 (32%), Positives = 79/170 (46%), Gaps = 26/170 (15%)
Query: 608 LYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLC---VTSRRPPQLLKSCNLD 664
++ W F CS +CGGG Q C + ++ + C + +P L+ CNLD
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
Query: 665 PCPA-----------------RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVIL 707
PCPA RWE W+ CS +CG G+Q+R V C + ++ V
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSC---VEEDIQGHVTS 414
Query: 708 ADE--LCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
+E PK Q CN F+C P W +W PC+ TCG G++ R VLC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 94.4 bits (233), Expect = 9e-19
Identities = 56/175 (32%), Positives = 74/175 (42%), Gaps = 31/175 (17%)
Query: 665 PCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR------QPKPS 718
P RW + PCS TCG G Q C L S ++AD+ C +PKP
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNR-----VVADQYCHYYPENIKPKPK 350
Query: 719 TVQACNRFNCP-----------------PAWYPAQWQPCSRTCGGGVQKREVLCKQRMAD 761
+Q CN CP P W W CS +CGGG+Q R V C +
Sbjct: 351 -LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQ 409
Query: 762 GSFLELPETFCS-ASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
G + E C K Q C DCP +WL +W+ C+ +CG+G + R +C
Sbjct: 410 GHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 83.2 bits (204), Expect = 2e-15
Identities = 62/180 (34%), Positives = 86/180 (47%), Gaps = 28/180 (15%)
Query: 523 EPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPID---ECEGPKPASQRACY 579
E F P C+ TCG G Q+ C L S ++ VAD E PKP Q C
Sbjct: 303 ETDFFP-----CSATCGGGYQLTSAECYDLRS-NRVVADQYCHYYPENIKPKPKLQE-CN 355
Query: 580 AGPCSGEIPEFNPDETDGLFGGLQDFD---ELYDWEYEGFTKCSESCGGGVQEAVVSCLN 636
PC +DG + + +D L WE +T CS SCGGG+Q VSC+
Sbjct: 356 LDPCPA---------SDG-YKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVE 405
Query: 637 KQTR---EPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFC 693
+ + EE C+ + + P + + CN+ CP +W +WSPC++TCG GL+ R V C
Sbjct: 406 EDIQGHVTSVEEWKCMYTPKMP-IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 76.3 bits (186), Expect = 3e-13
Identities = 54/193 (27%), Positives = 77/193 (39%), Gaps = 29/193 (15%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPAHC---AGKVRPAVQPIACNRRDC 1545
W CSA+CG G Q C L ++ V +C ++P + CN C
Sbjct: 301 WRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 1546 PS-----------------RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDM 1588
P+ RW T W+AC+ SCGGG+Q+R V+C + G T V
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 1589 CTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQ 1648
C K P+ Q CN C +W W C C +++R V C G + +
Sbjct: 420 CMYTPKMPI-AQPCNIFDCPKWLAQEWSPCTVTC---GQGLRYRVVLCIDHRG--MHTGG 473
Query: 1649 CSALPRPVSTQNC 1661
CS +P + C
Sbjct: 474 CSPKTKPHIKEEC 486
Score = 59.7 bits (143), Expect = 2e-08
Identities = 42/142 (29%), Positives = 55/142 (38%), Gaps = 25/142 (17%)
Query: 732 WYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLELPETFCSASKPACQQACKKD 786
W + PCS TCGGG Q C + +AD PE KP Q+ C D
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENI--KPKPKLQE-CNLD 357
Query: 787 DCPSE-----------------WLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNS 829
CP+ W + WT CS+SCG G Q+R+ C + G T V
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEE 417
Query: 830 TLCPPLPFSSSIRPCMLATCAR 851
C P +PC + C +
Sbjct: 418 WKCMYTPKMPIAQPCNIFDCPK 439
Score = 58.2 bits (139), Expect = 7e-08
Identities = 51/201 (25%), Positives = 74/201 (36%), Gaps = 31/201 (15%)
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
RW T + C+ +CGGG Q C L+++ + + K Q CN C
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 1608 ------------------VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD---GITLPS 1646
W + W C+ C G +Q R V C D +T
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG---GIQSRAVSCVEEDIQGHVTSVE 416
Query: 1647 E-QCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPE 1705
E +C P+ Q C C W W+ CT TCG G + R V C+ ++ +
Sbjct: 417 EWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQ-GLRYRVVLCI---DHRGMHT 471
Query: 1706 HLCSWGPRPANWQRCNI-TPC 1725
CS +P + C + TPC
Sbjct: 472 GGCSPKTKPHIKEECIVPTPC 492
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 330 bits (847), Expect = 6e-90
Identities = 278/980 (28%), Positives = 390/980 (39%), Gaps = 216/980 (22%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAG 86
+G W W P+S CSRTCGGG + RRC + C GR +++R+C+ CP
Sbjct: 556 NGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ 615
Query: 87 DFRAQQCS----AHNDVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLD 140
DFR +QCS H D+ WLP + + C L CQ GT L V D
Sbjct: 616 DFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVED 675
Query: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
GT C TE+ D+C+ G C GCDH L S+ K D CGVC GD S+C+ + G + S+
Sbjct: 676 GTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFN---SSHY 732
Query: 201 SDDTVVAIPYGSRHIRL----VLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 256
+ VV IP G+ ++ + PD YL +G + G FL+ S +
Sbjct: 733 GYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEG-----NFLFNGNFLLSTSKKEI 787
Query: 257 QKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI----FYQPIIH------RWRETDF 306
+ ++ +G A + N + +Q + Y P +H +D
Sbjct: 788 NVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
Query: 307 FP---------CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
F C+ C G Q + C + VV+D+ C + P P Q CN D
Sbjct: 848 FTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLP---LPSFVTQSCNTD 903
Query: 358 -------------PCPASDGYKQI----MPYDLYH------------------------- 375
GY+ + M Y ++
Sbjct: 904 CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHG 963
Query: 376 --PLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCN 433
RW + W+ CS SCGGG +SR C+ GH + E C ++ + CN
Sbjct: 964 NCVFTRWHYSEWSQCSRSCGGGERSRESYCMNN--FGHRLADNE--CQELSRV-TRENCN 1018
Query: 434 IFDCPKWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPHIKEECIVPT 490
F CP W A EWS C VTCG+G + R V C +DH + G C+ TKP C
Sbjct: 1019 EFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLSPC---- 1072
Query: 491 PCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQ 550
EL A+ P W CT TCG G Q+R V+C
Sbjct: 1073 ----------------------ELHTCASWQVGP------WGPCTTTCGHGYQMRDVKCV 1104
Query: 551 VLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELY 609
L + A L EC E +P+ +++C PCS + ET L L ++
Sbjct: 1105 NEL----ASAVLEDTECHEASRPSDRQSCVLTPCS----FISKLETALLPTVL--IKKMA 1154
Query: 610 DWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPAR 669
W + +T CS SCG G Q VSC + R A+E+ C RP ++ PC
Sbjct: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALDR-IADESYCAHLPRPAEIWDC--FTPC-GE 1210
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELC-RQPKPSTVQACNRFNC 728
W+ G WSPCS +CG G TR V C MN + + C + +P Q C+ C
Sbjct: 1211 WQAGDWSPCSASCGHGKTTRQVLC-------MNYHQPIDENYCDPEVRPLMEQECSLAAC 1263
Query: 729 PPA-----------------------------------------WYPAQWQPCSRTCGGG 747
PPA W W CS +C GG
Sbjct: 1264 PPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGG 1323
Query: 748 VQKREVLCKQRMADGSFLELPETFC-SASKPACQQACKKDDCPSEWLLSDWTECSTSCGE 806
+Q R V+C+ + ++C +ASKP Q C CP +W +W ECS +CG
Sbjct: 1324 LQHRAVVCQDENGQSA------SYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGG 1376
Query: 807 GTQTRSAICR----KMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPH 862
G ++R IC+ ++L+ +VN PP + C A + P T S
Sbjct: 1377 GIKSRLVICQFPNGQILEDHNCEIVNK---PPSVIQCHMHACP-ADVSWHQEPWTSCSAS 1432
Query: 863 IAAARK---VYIQTRRQRKL 879
RK V+ + QRKL
Sbjct: 1433 CGKGRKYREVFCIDQFQRKL 1452
Score = 228 bits (581), Expect = 4e-59
Identities = 157/527 (29%), Positives = 237/527 (44%), Gaps = 82/527 (15%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ + PC+ TCG GYQ+ +C + ++ V+ D CH E +P + Q C L PC
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECH---EASRPSDR-QSCVLTPCS 1135
Query: 361 -ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
S ++P L + +W WT CS SCG G Q+R VSC D + +E
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIA--DESY 1191
Query: 420 CMYTPKMPIAQPCNIFDC----PKWLAQEWSPCTVTCGQGLRYRVVLCID-HRGMHTGGC 474
C + P+ P I+DC +W A +WSPC+ +CG G R VLC++ H+ + C
Sbjct: 1192 CAHLPR-----PAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
Query: 475 SPKTKPHIKEECIVPT--PCYKPKEKLPVE------AKLPWFKQAQELEEGAAVSEEPS- 525
P+ +P +++EC + P + PV+ LP Q+LE+ PS
Sbjct: 1247 DPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPL---TQKLEDNENQVVHPSV 1303
Query: 526 ----FIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAG 581
+ W +C+ +C G Q R V CQ S S D KP + C G
Sbjct: 1304 RGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDA------ASKPPELQQCGPG 1357
Query: 582 PCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE 641
PC W Y + +CS++CGGG++ +V C +
Sbjct: 1358 PCP-------------------------QWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQ 1391
Query: 642 PAEENLCVTSRRPPQLLKSCNLDPCPA--RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSR 699
E++ C +PP +++ C++ CPA W W+ CS +CG G + R+VFC R
Sbjct: 1392 ILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQR 1450
Query: 700 EMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRM 759
++ +T + KP T +AC C P+W W CS TCG GVQ+R+V C+ +
Sbjct: 1451 KLEDT-----NCSQVQKPPTHKACRSVRC-PSWKANSWNECSVTCGSGVQQRDVYCRLKG 1504
Query: 760 ADGSFLELPETFCSAS-KPACQQACKKDDC-PSEWLLSDWTECSTSC 804
++ E C S +P Q+ C DC + + CSTSC
Sbjct: 1505 VG----QVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSC 1547
Score = 200 bits (509), Expect = 9e-51
Identities = 169/622 (27%), Positives = 244/622 (39%), Gaps = 131/622 (21%)
Query: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
+ RW +++ CS +CGGG + + C + +R+ AD C + + CN
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRL-ADNECQELSRVTR-----ENCNE 1019
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
CP+ W A+ W+ C +CG G + R V C Q +V +
Sbjct: 1020 FSCPS------------------WAASEWSECLVTCGKGTKQRQVWC-----QLNVDHLS 1056
Query: 417 EWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGG 473
+ C + K PC + C W W PCT TCG G + R V C++ +
Sbjct: 1057 DGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTE 1116
Query: 474 CSPKTKPHIKEECIV--------------PTPCYKPKEK------LPVEAKLPWFKQAQE 513
C ++P ++ C++ PT K + P QA+
Sbjct: 1117 CHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARY 1176
Query: 514 L-----------EEGAAVSEEPSFIPEA-----------WSACTVTCGVGTQVRIVRCQV 551
+ E A P+ I + WS C+ +CG G R V C
Sbjct: 1177 VSCRDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLC-- 1234
Query: 552 LLSFSQSVADLPIDE--CEGP-KPASQRACYAGPC---------SGEIPEFNPDETDGLF 599
+++ Q PIDE C+ +P ++ C C S P + L
Sbjct: 1235 -MNYHQ-----PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLT 1288
Query: 600 GGLQDFDELY--------DWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTS 651
L+D + W + CS SC GG+Q V C Q + C +
Sbjct: 1289 QKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC---QDENGQSASYCDAA 1345
Query: 652 RRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADEL 711
+PP+L + C PCP +W G W CS TCG G+++R V C + IL D
Sbjct: 1346 SKPPEL-QQCGPGPCP-QWNYGNWGECSQTCGGGIKSRLVIC------QFPNGQILEDHN 1397
Query: 712 CR-QPKPSTVQACNRFNCPP--AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELP 768
C KP +V C+ CP +W+ W CS +CG G + REV C D +L
Sbjct: 1398 CEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFC----IDQFQRKLE 1453
Query: 769 ETFCS-ASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV 827
+T CS KP +AC+ CPS W + W ECS +CG G Q R CR LK G+ VV
Sbjct: 1454 DTNCSQVQKPPTHKACRSVRCPS-WKANSWNECSVTCGSGVQQRDVYCR--LK-GVGQVV 1509
Query: 828 NSTLCPPLPFSSSIRPCMLATC 849
+C S RPC C
Sbjct: 1510 EE-MC-----DQSTRPCSQRRC 1525
Score = 156 bits (395), Expect = 1e-37
Identities = 131/502 (26%), Positives = 191/502 (38%), Gaps = 106/502 (21%)
Query: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
++WR + CS++C GG Q + C D Q Y KP P+LQ+C P
Sbjct: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENG------QSASYCDAASKP-PELQQCGPGP 1358
Query: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
CP +W W CS +CGGGI+SR V C + Q +E+
Sbjct: 1359 CP------------------QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ----ILEDH 1396
Query: 419 KCMYTPKMPIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCIDH--RGMHTGG 473
C K P C++ CP W + W+ C+ +CG+G +YR V CID R +
Sbjct: 1397 NCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN 1456
Query: 474 CSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSA 533
CS KP + C C PS+ +W+
Sbjct: 1457 CSQVQKPPTHKACR-SVRC-------------------------------PSWKANSWNE 1484
Query: 534 CTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFNP 592
C+VTCG G Q R V C++ + V + + C+ +P SQR C++ C
Sbjct: 1485 CSVTCGSGVQQRDVYCRL-----KGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH------ 1533
Query: 593 DETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSR 652
G++ G CS SC + C + Q R+ E + S
Sbjct: 1534 -------KGME----------RGRLNCSTSCERKDSHQRMECTDNQIRQVNE--IVYNSS 1574
Query: 653 RPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET----VILA 708
K+C PC S C+ CG + R +C+ + S + ++ I+
Sbjct: 1575 TISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVY 1634
Query: 709 DELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELP 768
E P Q N W +W CS TCG G+ KR+V C + S L L
Sbjct: 1635 QECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCL- 1693
Query: 769 ETFCSASKPACQQACKKDDCPS 790
+ KP Q+ C +DC S
Sbjct: 1694 ----NHLKPGAQKKCYANDCKS 1711
Score = 119 bits (299), Expect = 2e-26
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 20/241 (8%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNS------TEVNPAHCAGKVRPAVQPIACNRRD 1544
W V + CS+ CG +G + + C+ S +V+ +C +++P Q + C+
Sbjct: 908 WHVIGKSECSSQCG-QGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQEL-CHGNC 965
Query: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
+RW + WS C+RSCGGG ++R C + ++++ C ++++ V + CN+
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCM----NNFGHRLADNECQELSR--VTRENCNE 1019
Query: 1605 QLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSE 1664
C WA S W +C C + RQV+CQ L C++ +P S C
Sbjct: 1020 FSCPSWAASEWSECLVTC---GKGTKQRQVWCQLNVD-HLSDGFCNSSTKPESLSPCELH 1075
Query: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
C+ W+V W CT TCG +G+Q R V+CV+ + + + C RP++ Q C +TP
Sbjct: 1076 TCA-SWQVGPWGPCTTTCG-HGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTP 1133
Query: 1725 C 1725
C
Sbjct: 1134 C 1134
Score = 104 bits (259), Expect = 9e-22
Identities = 77/307 (25%), Positives = 117/307 (38%), Gaps = 77/307 (25%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCP---- 1546
W + CSASCG+ G ++ C+ ++ +C +VRP ++ C+ CP
Sbjct: 1211 WQAGDWSPCSASCGH-GKTTRQVLCMNYHQPIDENYCDPEVRPLMEQ-ECSLAACPPAHS 1268
Query: 1547 -------------------------------------SRWMVTSWSACTRSCGGGVQTRR 1569
++W W +C+ SC GG+Q R
Sbjct: 1269 HFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRA 1328
Query: 1570 VTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAV 1629
V CQ S A +P + Q C C +W + +WG+C+ C G +
Sbjct: 1329 VVCQDENGQSAS-------YCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGG---GI 1378
Query: 1630 QHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC--SVHWRVSLWTLCTATCGNYGF 1687
+ R V CQ +G L C + +P S C AC V W WT C+A+CG G
Sbjct: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK-GR 1437
Query: 1688 QSRRVECV----------------HARTNKAVPEHLC-SWGPRPANWQRCNITPCENMEC 1730
+ R V C+ T+KA C SW + +W C++T ++
Sbjct: 1438 KYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSW--KANSWNECSVTCGSGVQQ 1495
Query: 1731 RDTTRYC 1737
RD YC
Sbjct: 1496 RDV--YC 1500
Score = 100 bits (250), Expect = 1e-20
Identities = 76/300 (25%), Positives = 124/300 (41%), Gaps = 55/300 (18%)
Query: 1446 HILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGN 1505
H LA + +++ ++ + EFSC + W+ + C +CG
Sbjct: 999 HRLADNECQELSRVTRENCNEFSCPS-------------------WAASEWSECLVTCG- 1038
Query: 1506 RGVQQPRLRCLLNSTEVNPAHCAGKVRP-AVQPIACNRRDCPSRWMVTSWSACTRSCGGG 1564
+G +Q ++ C LN ++ C +P ++ P C C S W V W CT +CG G
Sbjct: 1039 KGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSP--CELHTCAS-WQVGPWGPCTTTCGHG 1095
Query: 1565 VQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC----------------- 1607
Q R V C + +++ V D A RP D Q+C C
Sbjct: 1096 YQMRDVKC----VNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIK 1151
Query: 1608 --VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
+W SW C+ C Q R V C+ C+ LPRP +C++
Sbjct: 1152 KMAQWRHGSWTPCSVSC---GRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTP- 1207
Query: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
C W+ W+ C+A+CG +G +R+V C++ ++ + E+ C RP Q C++ C
Sbjct: 1208 CG-EWQAGDWSPCSASCG-HGKTTRQVLCMN--YHQPIDENYCDPEVRPLMEQECSLAAC 1263
Score = 96.7 bits (239), Expect = 2e-19
Identities = 63/238 (26%), Positives = 104/238 (43%), Gaps = 18/238 (7%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W +CS+SC G+Q + C + + + ++C +P + C CP +W
Sbjct: 1308 WRTGPWGSCSSSCSG-GLQHRAVVCQDENGQ-SASYCDAASKPP-ELQQCGPGPCP-QWN 1363
Query: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC--- 1607
+W C+++CGGG+++R V CQ + D ++ +P C+ C
Sbjct: 1364 YGNWGECSQTCGGGIKSRLVICQFPNGQ-----ILEDHNCEIVNKPPSVIQCHMHACPAD 1418
Query: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACS 1667
V W W C+ C ++R+VFC + L CS + +P + + C S C
Sbjct: 1419 VSWHQEPWTSCSASC---GKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP 1475
Query: 1668 VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
W+ + W C+ TCG+ G Q R V C + V E +C RP + +RC C
Sbjct: 1476 -SWKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVV-EEMCDQSTRPCSQRRCWSQDC 1530
Score = 94.4 bits (233), Expect = 9e-19
Identities = 74/261 (28%), Positives = 97/261 (37%), Gaps = 34/261 (13%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W + CS SCG G ++ R +N+ A + V CN CPS W
Sbjct: 970 WHYSEWSQCSRSCG--GGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPS-WA 1026
Query: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEW 1610
+ WS C +CG G + R+V CQ L +S N + +P C C W
Sbjct: 1027 ASEWSECLVTCGKGTKQRQVWCQ-LNVDHLSDGFCNS-----STKPESLSPCELHTCASW 1080
Query: 1611 AFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPSEQCSALPRPVSTQNCWSEACS-- 1667
WG C C + Q R V C L +C RP Q+C CS
Sbjct: 1081 QVGPWGPCTTTCGHGY---QMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
Query: 1668 ----------------VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
WR WT C+ +CG G Q+R V C A ++ E C+
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSCRDA-LDRIADESYCAHL 1195
Query: 1712 PRPANWQRCNITPCENMECRD 1732
PRPA C TPC + D
Sbjct: 1196 PRPAEIWDC-FTPCGEWQAGD 1215
Score = 92.8 bits (229), Expect = 3e-18
Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 27/279 (9%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPS--R 1548
W+ CS +CG G++ + C + ++ H V I C+ CP+
Sbjct: 1362 WNYGNWGECSQTCGG-GIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVS 1420
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W W++C+ SCG G + R V C + + C+QV K P +AC C
Sbjct: 1421 WHQEPWTSCSASCGKGRKYREVFC----IDQFQRKLEDTNCSQVQKPPTH-KACRSVRCP 1475
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSV 1668
W +SW +C+ C VQ R V+C+ + + E C RP S + CWS+ C
Sbjct: 1476 SWKANSWNECSVTCGS---GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQ 1532
Query: 1669 HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC--- 1725
H + L +T +R+EC + + V E + + + C PC
Sbjct: 1533 HKGMERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEIVYNSSTISLTSKNCRNPPCNYI 1591
Query: 1726 ----ENMEC--------RDTTRYCEKVKQLKLCQLSQFK 1752
++ +C R YC ++ K +L + +
Sbjct: 1592 VVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLR 1630
Score = 73.9 bits (180), Expect = 1e-12
Identities = 70/277 (25%), Positives = 117/277 (42%), Gaps = 27/277 (9%)
Query: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLN-STEVNPAHCAGKVRPAVQPIACNRRDCP 1546
D W + +CSASCG +G + + C+ ++ +C+ +P AC CP
Sbjct: 1418 DVSWHQEPWTSCSASCG-KGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHK-ACRSVRCP 1475
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
S W SW+ C+ +CG GVQ R V C +LK G V +MC Q + RP + C Q
Sbjct: 1476 S-WKANSWNECSVTCGSGVQQRDVYC-RLKGVG---QVVEEMCDQ-STRPCSQRRCWSQD 1529
Query: 1607 CVEWAFSSWGQ--CNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSE 1664
CV+ G+ C+ C H+++ C + ++ ++++NC +
Sbjct: 1530 CVQHKGMERGRLNCSTSC---ERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNP 1586
Query: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
C+ + + C CG + ++ R C + K H RP +Q C + P
Sbjct: 1587 PCNYIVVTADSSQCANNCG-FSYRQRITYCTEIPSTKKHKLHRL----RPIVYQECPVVP 1641
Query: 1725 CENM-ECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCG 1760
+ +C ++ + K K S+C TCG
Sbjct: 1642 SSQVYQCINSCLHLATWKVGKW-------SKCSVTCG 1671
Score = 56.6 bits (135), Expect = 2e-07
Identities = 63/253 (24%), Positives = 96/253 (37%), Gaps = 34/253 (13%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNST-EVNPAHCAGKVRPAVQPIACNRRDCPS-R 1548
W + CS +CG+ GVQQ + C L +V C RP Q C +DC +
Sbjct: 1477 WKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQR-RCWSQDCVQHK 1534
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
M C+ SC +R+ C + ++ V N + + CN V
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNY--IV 1592
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPR--PVSTQNCWSEAC 1666
A SS QC C + + R +C +PS + L R P+ Q C
Sbjct: 1593 VTADSS--QCANNC---GFSYRQRITYCTE-----IPSTKKHKLHRLRPIVYQECPVVPS 1642
Query: 1667 S------------VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRP 1714
S W+V W+ C+ TCG G R+V+C+ T + LC +P
Sbjct: 1643 SQVYQCINSCLHLATWKVGKWSKCSVTCG-IGIMKRQVKCI---TKHGLSSDLCLNHLKP 1698
Query: 1715 ANWQRCNITPCEN 1727
++C C++
Sbjct: 1699 GAQKKCYANDCKS 1711
Score = 49.3 bits (116), Expect = 3e-05
Identities = 83/370 (22%), Positives = 125/370 (33%), Gaps = 55/370 (14%)
Query: 39 WGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHND 98
+G W ECS+TCGGG L C + G+ + C V+ PP C A D
Sbjct: 1364 YGNWGECSQTCGGGIKSRLVIC---QFPNGQILEDHNCEIVNKPPSVIQCHMHACPA--D 1418
Query: 99 VKHHGQFYEWLPVSNDPDNPCSLKCQAKG----TTLVVELAPKVLDGTRCYTESLDMCIS 154
V H +P CS C KG ++ + L+ T C ++
Sbjct: 1419 VSWH----------QEPWTSCSASC-GKGRKYREVFCIDQFQRKLEDTNC-SQVQKPPTH 1466
Query: 155 GLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRH 214
C+ V C ++ E C V G G R V + K + P R
Sbjct: 1467 KACRSVRCPSWKANSWNE--CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRR 1524
Query: 215 IRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTAD 274
+Q E + T S + D +I R +
Sbjct: 1525 C-----------WSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEI--- 1569
Query: 275 FIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
+ NS + T + P + D C+ CG Y+ C ++ S +
Sbjct: 1570 ----VYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTK--- 1622
Query: 335 DQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG 394
+ ++P QEC + P+S Y+ I H L W+ W+ CS +CG
Sbjct: 1623 ----KHKLHRLRP-IVYQECPV--VPSSQVYQCI--NSCLH-LATWKVGKWSKCSVTCGI 1672
Query: 395 GIQSRAVSCV 404
GI R V C+
Sbjct: 1673 GIMKRQVKCI 1682
Score = 37.4 bits (85), Expect = 0.13
Identities = 38/167 (22%), Positives = 60/167 (35%), Gaps = 19/167 (11%)
Query: 667 PARWEIGKWSP---CSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQAC 723
P E G W P CS TCG G+++ C+ R + + ++C
Sbjct: 554 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCV--------GRRMKFRSC 605
Query: 724 NRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQAC 783
N +CP + + CS G + + R LP +K C+ C
Sbjct: 606 NTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRW-------LPRYSGIGTKDRCKLYC 658
Query: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNST 830
+ +LL D E T CG T + + + G V+NS+
Sbjct: 659 QVAGTNYFYLLKDMVEDGTPCGTETHD-ICVQGQCMAAGCDHVLNSS 704
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 309 bits (792), Expect = 1e-83
Identities = 249/901 (27%), Positives = 372/901 (41%), Gaps = 193/901 (21%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPPEAG 86
DG W +W P+ CSRTCGGG ++R C K C GR +++++C+ C +
Sbjct: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKR 647
Query: 87 DFRAQQCSAHNDVKHHG-----QFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVL 139
DFR +QC AH D KH W+P + + C L C+ G T +L +V+
Sbjct: 648 DFRDEQC-AHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVI 706
Query: 140 DGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
DGT C ++ D+C+ GLC+ GCDH L S + D CGVC GD S+C+ V G + +
Sbjct: 707 DGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN---TVH 763
Query: 200 KSDDTVVAIPYGSRHIRLVL-----KGPDHLYLETKTLQGTKGENSLSSTGTFLV----- 249
+TVV IP G+ +I + + D YL L +KGE L+ G F+V
Sbjct: 764 YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL---ALSSSKGEFLLN--GNFVVTMAKR 818
Query: 250 ----DNSSVDFQKFPDK-EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQPIIHR--- 300
N+ V++ E + + + ++++ + G + V++ F PI +
Sbjct: 819 EIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQ 878
Query: 301 --WR-ETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPE-NIKPKPKLQECNL 356
W + CS C G + C V+DQ C P+ +P +C+L
Sbjct: 879 FYWNSHGPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDL 937
Query: 357 -------DPCPASD--GYKQIMPYDLY---------------------HPLPR------- 379
C A GY+ + D+Y HP P
Sbjct: 938 RWHVASRSECSAQCGLGYRTL---DIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSG 994
Query: 380 ------WEATPWTACSSSCGGGIQSRAVSCV--EEDIQGHVTSVEEWKCMYTPKMPIAQP 431
W + WT CS SC GG Q R CV D+ +++ KC + K+ I Q
Sbjct: 995 ECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV------LDDSKCTHQEKVTI-QR 1047
Query: 432 CNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC-IDHRGMHTGGCSPKTKPHIKEECIVPT 490
C+ F CP+W + +WS C VTCG+G ++R V C ++ C P+TKP + C P
Sbjct: 1048 CSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQP- 1106
Query: 491 PCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQ 550
E S+ W C+VTCG G Q+R V+C
Sbjct: 1107 -------------------------------ECASWQAGPWGQCSVTCGQGYQLRAVKC- 1134
Query: 551 VLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELY 609
++ SV D ++C +P + C C P P+ + +
Sbjct: 1135 -IIGTYMSVVD--DNDCNAATRPTDTQDCELPSC--HPPPAAPETRRSTYSAPRT----- 1184
Query: 610 DWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPAR 669
W + +T CS +CG G + VSC + A+E+ C T R P + C++ PC +
Sbjct: 1185 QWRFGSWTPCSATCGKGTRMRYVSC-RDENGSVADESACATLPR-PVAKEECSVTPC-GQ 1241
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
W+ WS CS+TCG G TR V C + ++ VI E + P T Q C+ CP
Sbjct: 1242 WKALDWSSCSVTCGQGRATRQVMCVN-----YSDHVIDRSECDQDYIPETDQDCSMSPCP 1296
Query: 730 P---------------------------------AWYPAQWQPCSRTCGGGVQKREVLCK 756
W W CS TC GG Q+R V+C+
Sbjct: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
Query: 757 QRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
KP Q+AC+ CP +W +W EC+ CG G +TR +C+
Sbjct: 1357 DENG-----YTANDCVERIKPDEQRACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQ 1410
Query: 817 K 817
+
Sbjct: 1411 R 1411
Score = 229 bits (583), Expect = 2e-59
Identities = 157/534 (29%), Positives = 238/534 (44%), Gaps = 69/534 (12%)
Query: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPK-LQE 353
QP W+ + CS TCG GYQL + +C VV D C N +P Q+
Sbjct: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-----NAATRPTDTQD 1159
Query: 354 CNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT 413
C L C + P +W WT CS++CG G + R VSC +E+ G V
Sbjct: 1160 CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEN--GSVA 1217
Query: 414 SVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHT 471
+E C P+ + C++ C +W A +WS C+VTCGQG R V+C+++ +
Sbjct: 1218 --DESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDR 1275
Query: 472 GGCSPKTKPHIKEEC-IVPTPCYKPKEKLPVEAKLPW----FKQAQELEEGAAVSEEPSF 526
C P ++C + P P P L A+ P+ ++ V +
Sbjct: 1276 SECDQDYIPETDQDCSMSPCPQRTPDSGL---AQHPFQNEDYRPRSASPSRTHVLGGNQW 1332
Query: 527 IPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGE 586
W AC+ TC G+Q R+V CQ ++ + D E KP QRAC +GPC
Sbjct: 1333 RTGPWGACSSTCAGGSQRRVVVCQDENGYTAN------DCVERIKPDEQRACESGPCP-- 1384
Query: 587 IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN 646
W Y + +C++ CGGG++ +V C + E +
Sbjct: 1385 -----------------------QWAYGNWGECTKLCGGGIRTRLVVC-QRSNGERFPDL 1420
Query: 647 LCVTSRRPPQLLKSCNLDPCP--ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
C +PP + CN CP A W G WS CS++CG G + R+V+C ++++ +
Sbjct: 1421 SCEILDKPPD-REQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYC---MAKDGSH- 1475
Query: 705 VILADELCRQ-PKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGS 763
L + C+ KP + C C P W W CS +CG GVQ+R V C+ G+
Sbjct: 1476 --LESDYCKHLAKPHGHRKCRGGRC-PKWKAGAWSQCSVSCGRGVQQRHVGCQ----IGT 1528
Query: 764 FLELPETFCSA-SKPACQQACKKDDCP-SEWLLSDWTECSTSCGEGTQTRSAIC 815
ET C+ ++P ++ C+ CP W +W EC+ +CGEG++ R +C
Sbjct: 1529 HKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVC 1582
Score = 194 bits (492), Expect = 8e-49
Identities = 202/840 (24%), Positives = 291/840 (34%), Gaps = 168/840 (20%)
Query: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS--------SKSCEGRNIRY 73
S+R S E G W + W+ECS++C GG C++ SK +
Sbjct: 987 SNREKCSGECNTGGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTI 1045
Query: 74 RTCSNVDCPP-EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV 132
+ CS CP ++GD+ + KH W D N + K T++
Sbjct: 1046 QRCSEFPCPQWKSGDWSECLVTCGKGHKHR---QVWCQFGEDRLNDRMCDPETKPTSMQT 1102
Query: 133 ELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY 192
P+ C S G C V G G R V+
Sbjct: 1103 CQQPE--------------CASWQAGPWG------------QCSVTCGQGYQLRAVKCII 1136
Query: 193 KSQLSATKSDDTVVAI-PYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDN 251
+ +S +D A P ++ L P ET+ T+
Sbjct: 1137 GTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRR-------------STYSAPR 1183
Query: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH---------RWR 302
+ F + G + N AD + +P+ +W+
Sbjct: 1184 TQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWK 1243
Query: 303 ETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCH--YYPENIKPKPKLQECNLDPCP 360
D+ CS TCG G C + S+ V+ C Y PE Q+C++ PCP
Sbjct: 1244 ALDWSSCSVTCGQGRATRQVMCVNY-SDHVIDRSECDQDYIPETD------QDCSMSPCP 1296
Query: 361 --ASDGYKQIMPYDLYHPLPR--------------WEATPWTACSSSCGGGIQSRAVSCV 404
D P+ PR W PW ACSS+C GG Q R V C
Sbjct: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
Query: 405 EEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCI 464
+E+ G+ + C+ K + C CP+W W CT CG G+R R+V+C
Sbjct: 1357 DEN--GYTAN----DCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQ 1410
Query: 465 DHRGMHTG--GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSE 522
G C KP +E+C AA S
Sbjct: 1411 RSNGERFPDLSCEILDKPPDREQC-----------------------NTHACPHDAAWST 1447
Query: 523 EPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPASQRACYAG 581
P WS+C+V+CG G + R V C ++ + L D C+ KP R C G
Sbjct: 1448 GP------WSSCSVSCGRGHKQRNVYCM-----AKDGSHLESDYCKHLAKPHGHRKCRGG 1496
Query: 582 PCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE 641
C W+ +++CS SCG GVQ+ V C T +
Sbjct: 1497 RCP-------------------------KWKAGAWSQCSVSCGRGVQQRHVGC-QIGTHK 1530
Query: 642 PAEENLCVTSRRPPQLLKSCNLDPCPA-RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSRE 700
A E C RP + + C CP W +W C+ TCG G + R V C +
Sbjct: 1531 IARETECNPYTRP-ESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCV-----D 1584
Query: 701 MNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMA 760
N+ + +P ++C+ C W +W CS TCG G ++R V C +
Sbjct: 1585 DNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT 1644
Query: 761 DGSFLELPETF---CSASKPACQQACKKDDCP--SEWLLSDWTECSTSCGEGTQTRSAIC 815
E C ++P C DCP + W + +W CS SCG G RS C
Sbjct: 1645 GKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQC 1704
Score = 129 bits (324), Expect = 3e-29
Identities = 118/477 (24%), Positives = 192/477 (40%), Gaps = 109/477 (22%)
Query: 404 VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK---WLAQ-EWSPCTVTCGQGLRYR 459
+E+++ V SV + +Y P + + I D P+ W + W C+ C QG R R
Sbjct: 845 IEQELLLQVLSVGK---LYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKR 900
Query: 460 VVLCI---DHRGMHTGGCSPKTKP-HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELE 515
++C D + C +P HI E C + L W ++
Sbjct: 901 KLVCTRESDQLTVSDQRCDRLPQPGHITEPC-------------GTDCDLRWHVASR--- 944
Query: 516 EGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPAS 574
S C+ CG+G + + C + C PKP++
Sbjct: 945 ----------------SECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN 988
Query: 575 QRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC 634
+ C +G C+ GG W Y +T+CS+SC GG Q C
Sbjct: 989 REKC-SGECNT--------------GG---------WRYSAWTECSKSCDGGTQRRRAIC 1024
Query: 635 LNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS 694
+N + + +++ C + ++ C+ PCP +W+ G WS C +TCG G + R V+C
Sbjct: 1025 VNTRN-DVLDDSKCTHQEKVT--IQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWCQ 1080
Query: 695 HLLSREMNETVILADELCR-QPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREV 753
R L D +C + KP+++Q C + C +W W CS TCG G Q R V
Sbjct: 1081 FGEDR-------LNDRMCDPETKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQGYQLRAV 1132
Query: 754 LCKQRMADGSFLEL-PETFCSAS-KPACQQACKKDDCP-----------------SEWLL 794
C G+++ + + C+A+ +P Q C+ C ++W
Sbjct: 1133 KC----IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRF 1188
Query: 795 SDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR 851
WT CS +CG+GT+ R CR + G +V + + C LP + C + C +
Sbjct: 1189 GSWTPCSATCGKGTRMRYVSCRD--ENG--SVADESACATLPRPVAKEECSVTPCGQ 1241
Score = 127 bits (318), Expect = 1e-28
Identities = 159/690 (23%), Positives = 240/690 (34%), Gaps = 126/690 (18%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCL-----SSKSCEGRNIRYRTCSNVDC-------PP 83
W A GPW +CS TCG G +C+ S N R DC PP
Sbjct: 1111 WQA-GPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPP 1169
Query: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV----ELAPKVL 139
A + R SA + +F W PCS C KGT + + V
Sbjct: 1170 AAPETRRSTYSAP---RTQWRFGSW--------TPCSATC-GKGTRMRYVSCRDENGSVA 1217
Query: 140 DGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
D + C T + C + C + +C V G G R V S
Sbjct: 1218 DESACATLPRPVAKEE-CSVTPCGQW--KALDWSSCSVTCGQGRATRQVMCVNYSDHVID 1274
Query: 200 KSDDTVVAIPYGSRHIRLV---LKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 256
+S+ IP + + + PD + S S + T ++ +
Sbjct: 1275 RSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRT 1334
Query: 257 QKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR---------WRETDFF 307
+ G + + N +A+ V+ I +P R W ++
Sbjct: 1335 GPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERI--KPDEQRACESGPCPQWAYGNWG 1392
Query: 308 PCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQ 367
C+ CGGG + C RSN +++ E + P ++CN CP
Sbjct: 1393 ECTKLCGGGIRTRLVVCQ--RSN---GERFPDLSCEILDKPPDREQCNTHACPHDAA--- 1444
Query: 368 IMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMP 427
W PW++CS SCG G + R V C+ +D + +E C + K
Sbjct: 1445 ------------WSTGPWSSCSVSCGRGHKQRNVYCMAKD----GSHLESDYCKHLAKPH 1488
Query: 428 IAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCI--DHRGMHTGGCSPKTKPHIKEE 485
+ C CPKW A WS C+V+CG+G++ R V C H+ C+P T+P + +
Sbjct: 1489 GHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERD 1548
Query: 486 CIVP---------------------------TPCYKPKEKLPVEAKLPWFKQAQELEEGA 518
C P C + A+ K+ + E +
Sbjct: 1549 CQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCS 1608
Query: 519 AVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSV--ADLPIDECEGPKPASQR 576
E +I WS C+VTCG G + R+V C + + ++ + C G +P S
Sbjct: 1609 LQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH 1668
Query: 577 ACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLN 636
CY L+D W + CS SCG GV + V CL
Sbjct: 1669 PCY----------------------LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL- 1705
Query: 637 KQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
T E +LC T +P + N+ C
Sbjct: 1706 --TNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Score = 115 bits (289), Expect = 3e-25
Identities = 70/238 (29%), Positives = 106/238 (44%), Gaps = 18/238 (7%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W CS++C G Q R+ + C +++P Q AC CP +W
Sbjct: 1332 WRTGPWGACSSTCA--GGSQRRVVVCQDENGYTANDCVERIKPDEQR-ACESGPCP-QWA 1387
Query: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC--- 1607
+W CT+ CGGG++TR V CQ+ ++G P D+ ++ +P D + CN C
Sbjct: 1388 YGNWGECTKLCGGGIRTRLVVCQR--SNGERFP---DLSCEILDKPPDREQCNTHACPHD 1442
Query: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACS 1667
W+ W C+ C H + R V+C +DG L S+ C L +P + C C
Sbjct: 1443 AAWSTGPWSSCSVSCGRGH---KQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCP 1499
Query: 1668 VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
W+ W+ C+ +CG G Q R V C T+K E C+ RP + + C C
Sbjct: 1500 -KWKAGAWSQCSVSCGR-GVQQRHVGC-QIGTHKIARETECNPYTRPESERDCQGPRC 1554
Score = 113 bits (283), Expect = 1e-24
Identities = 78/285 (27%), Positives = 117/285 (41%), Gaps = 31/285 (10%)
Query: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLNST------EVNPAHCAGKVRPAVQPIACN 1541
D W V + CSA CG G + + C S +V+ C+ +P+ N
Sbjct: 936 DLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPS------N 988
Query: 1542 RRDCPSR-----WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP 1596
R C W ++W+ C++SC GG Q RR C + + + + CT K
Sbjct: 989 REKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTR----NDVLDDSKCTHQEK-- 1042
Query: 1597 VDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPV 1656
V Q C++ C +W W +C C H +HRQV+CQ + L C +P
Sbjct: 1043 VTIQRCSEFPCPQWKSGDWSECLVTCGKGH---KHRQVWCQFGED-RLNDRMCDPETKPT 1098
Query: 1657 STQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPAN 1716
S Q C C+ W+ W C+ TCG G+Q R V+C+ V ++ C+ RP +
Sbjct: 1099 SMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNAATRPTD 1156
Query: 1717 WQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Q C + C TR + + + C TCGK
Sbjct: 1157 TQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSW-TPCSATCGK 1200
Score = 107 bits (268), Expect = 8e-23
Identities = 74/261 (28%), Positives = 103/261 (39%), Gaps = 34/261 (13%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEV-NPAHCAGKVRPAVQPIACNRRDCPSRW 1549
W CS SC G Q+ R C+ +V + + C + + +Q C+ CP +W
Sbjct: 1001 WRYSAWTECSKSCDG-GTQRRRAICVNTRNDVLDDSKCTHQEKVTIQ--RCSEFPCP-QW 1056
Query: 1550 MVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVE 1609
WS C +CG G + R+V CQ ND +P Q C Q C
Sbjct: 1057 KSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPETKPTSMQTCQQPECAS 1110
Query: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSE-QCSALPRPVSTQNCWSEAC-- 1666
W WGQC+ C Q R V C +++ + C+A RP TQ+C +C
Sbjct: 1111 WQAGPWGQCSVTC---GQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHP 1167
Query: 1667 ---------------SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
WR WT C+ATCG G + R V C E C+
Sbjct: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSC-RDENGSVADESACATL 1225
Query: 1712 PRPANWQRCNITPCENMECRD 1732
PRP + C++TPC + D
Sbjct: 1226 PRPVAKEECSVTPCGQWKALD 1246
Score = 105 bits (262), Expect = 4e-22
Identities = 68/253 (26%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W + C +CG +G + ++ C +N C + +P C + +C S W
Sbjct: 1056 WKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQ-TCQQPECAS-WQ 1112
Query: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC--- 1607
W C+ +CG G Q R V C G V +D A RP DTQ C C
Sbjct: 1113 AGPWGQCSVTCGQGYQLRAVKC----IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
Query: 1608 ---------------VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSAL 1652
+W F SW C+ C + R V C+ +G C+ L
Sbjct: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATC---GKGTRMRYVSCRDENGSVADESACATL 1225
Query: 1653 PRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGP 1712
PRPV+ + C C W+ W+ C+ TCG G +R+V CV+ ++ + C
Sbjct: 1226 PRPVAKEECSVTPCG-QWKALDWSSCSVTCGQ-GRATRQVMCVN-YSDHVIDRSECDQDY 1282
Query: 1713 RPANWQRCNITPC 1725
P Q C+++PC
Sbjct: 1283 IPETDQDCSMSPC 1295
Score = 105 bits (261), Expect = 5e-22
Identities = 79/266 (29%), Positives = 114/266 (42%), Gaps = 32/266 (12%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEV-NPAHCAGKVRPAVQPIACNRRDCPS-R 1548
W + CS SCG RGVQQ + C + + ++ C RP + C CP
Sbjct: 1501 WKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESER-DCQGPRCPLYT 1558
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC- 1607
W W CT++CG G + R+V C V C V+KRPVD ++C+ Q C
Sbjct: 1559 WRAEEWQECTKTCGEGSRYRKVVC----VDDNKNEVHGARC-DVSKRPVDRESCSLQPCE 1613
Query: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQT----RDGITLPSEQCSALP--RPVSTQNC 1661
W W +C+ C + R V C ++ + P +P S C
Sbjct: 1614 YVWITGEWSECSVTC---GKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
Query: 1662 WSEACSVH--WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQR 1719
+ C V WRV W C+ +CG G R V+C+ TN+ P HLC +P +
Sbjct: 1671 YLRDCPVSATWRVGNWGSCSVSCG-VGVMQRSVQCL---TNEDQPSHLCHTDLKPEERKT 1726
Query: 1720 C-NITPCENMECRDTTRYCEKVKQLK 1744
C N+ CE + C++VK+LK
Sbjct: 1727 CRNVYNCE------LPQNCKEVKRLK 1746
Score = 95.5 bits (236), Expect = 4e-19
Identities = 73/300 (24%), Positives = 117/300 (39%), Gaps = 51/300 (17%)
Query: 1462 GSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE 1521
GS + S A V ++ S+ W ++D ++CS +CG +G ++ C+ S
Sbjct: 1214 GSVADESACATLPRPVAKEECSVTPCGQWKALD-WSSCSVTCG-QGRATRQVMCVNYSDH 1271
Query: 1522 V-NPAHCAGKVRPAVQPIACNRRDCPSR-------------------------------- 1548
V + + C P C+ CP R
Sbjct: 1272 VIDRSECDQDYIPETDQ-DCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGN 1330
Query: 1549 -WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
W W AC+ +C GG Q R V CQ +ND ++ +P + +AC C
Sbjct: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQDENGY-----TANDCVERI--KPDEQRACESGPC 1383
Query: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC- 1666
+WA+ +WG+C C G ++ R V CQ +G P C L +P + C + AC
Sbjct: 1384 PQWAYGNWGECTKLCGG---GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
Query: 1667 -SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
W W+ C+ +CG G + R V C+ A+ + C +P ++C C
Sbjct: 1441 HDAAWSTGPWSSCSVSCGR-GHKQRNVYCM-AKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
Score = 94.7 bits (234), Expect = 7e-19
Identities = 67/247 (27%), Positives = 102/247 (41%), Gaps = 17/247 (6%)
Query: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLL-NSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
D WS ++CS SCG RG +Q + C+ + + + +C +P C CP
Sbjct: 1442 DAAWSTGPWSSCSVSCG-RGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHR-KCRGGRCP 1499
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST-PVSNDMCTQVAKRPVDTQACNQQ 1605
+W +WS C+ SCG GVQ R V CQ I T ++ + RP + C
Sbjct: 1500 -KWKAGAWSQCSVSCGRGVQQRHVGCQ------IGTHKIARETECNPYTRPESERDCQGP 1552
Query: 1606 LC--VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
C W W +C C ++R+V C + + +C RPV ++C
Sbjct: 1553 RCPLYTWRAEEWQECTKTC---GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
Query: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
+ C W W+ C+ TCG G++ R V C T K E+ Q ++
Sbjct: 1610 QPCEYVWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH 1668
Query: 1724 PCENMEC 1730
PC +C
Sbjct: 1669 PCYLRDC 1675
Score = 80.1 bits (196), Expect = 2e-14
Identities = 55/210 (26%), Positives = 82/210 (39%), Gaps = 39/210 (18%)
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNL 356
++ WR ++ C+ TCG G + C D N V H ++ +P +E C+L
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV------HGARCDVSKRPVDRESCSL 1609
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
PC W W+ CS +CG G + R VSC E T E
Sbjct: 1610 QPCEYV-----------------WITGEWSECSVTCGKGYKQRLVSCSEI-----YTGKE 1647
Query: 417 EWKCMYTPKM-------PIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
++ Y + P PC + DCP W W C+V+CG G+ R V C+ +
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
Query: 467 RGMHTGGCSPKTKPHIKEECIVPTPCYKPK 496
+ C KP ++ C C P+
Sbjct: 1708 EDQPSHLCHTDLKPEERKTCRNVYNCELPQ 1737
Score = 71.6 bits (174), Expect = 6e-12
Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 34/213 (15%)
Query: 1554 WSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFS 1613
W AC++ C G + R++ C + VS+ C ++ + T+ C + W +
Sbjct: 887 WQACSKPCQGE-RKRKLVCTR---ESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVA 942
Query: 1614 SWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQ-----CSALPRPVSTQNCWSEACSV 1668
S +C+ C L + ++C + +E+ CS+ P+P + + C E +
Sbjct: 943 SRSECSAQC---GLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTG 999
Query: 1669 HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENM 1728
WR S WT C+ +C G Q RR CV+ R N + + C+ + QRC+ PC
Sbjct: 1000 GWRYSAWTECSKSCDG-GTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPCPQW 1056
Query: 1729 ECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
+ D S C TCGK
Sbjct: 1057 KSGDW-------------------SECLVTCGK 1070
Score = 53.9 bits (128), Expect = 1e-06
Identities = 33/103 (32%), Positives = 47/103 (45%), Gaps = 13/103 (12%)
Query: 1480 QKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCL--------LNSTEVNPAHCAGKV 1531
+ SL +Y W + CS +CG +G +Q + C + +C G
Sbjct: 1605 ESCSLQPCEYVWITGEWSECSVTCG-KGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ 1663
Query: 1532 RPAVQPIACNRRDCP--SRWMVTSWSACTRSCGGGVQTRRVTC 1572
P+V P C RDCP + W V +W +C+ SCG GV R V C
Sbjct: 1664 PPSVHP--CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQC 1704
Score = 38.1 bits (87), Expect = 0.076
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 23/101 (22%)
Query: 566 ECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG 625
ECE K C P ++P TDG +G + F CS +CGG
Sbjct: 565 ECEPGKHCKYGFCV--PKEMDVPV-----TDGSWGS-----------WSPFGTCSRTCGG 606
Query: 626 GVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
G++ A+ C + + + CV R KSCN +PC
Sbjct: 607 GIKTAIRECNRPEPKNGGK--YCVGRR---MKFKSCNTEPC 642
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 292 bits (748), Expect = 2e-78
Identities = 195/594 (32%), Positives = 268/594 (45%), Gaps = 98/594 (16%)
Query: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPP 83
E DG W W PW +CSRTCGGG S S R C + K C G R+R+C+ DCPP
Sbjct: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPP 603
Query: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
+ DFR QCS + + G+FY+W CSL C A+G E A V+DGT
Sbjct: 604 GSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
Query: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDD 203
C +++D+C+SG C+ VGCD LGS ++ED C VC GDGS C + G + S S +
Sbjct: 664 CRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVF-SPASPGAGYE 722
Query: 204 TVVAIPYGSRHI----------RLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSS 253
VV IP GS HI L LKG D L + L GT + L GT +
Sbjct: 723 DVVWIPKGSVHIFIQDLNLSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGT------T 775
Query: 254 VDFQKFPDK-EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------HRWRETDF 306
++ PD+ + L GP+ A IV + + + +++ F PI + W +
Sbjct: 776 FQLRQGPDQVQSLEALGPINASLIVMVL-ARTELPALRYRFNAPIARDSLPPYSWHYAPW 834
Query: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNLDPCPASDGY 365
CSA C GG Q+ + EC + + VA YC + + PK Q CN +PCP
Sbjct: 835 TKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSK----LPKRQRACNTEPCP----- 885
Query: 366 KQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
P W W+ CS SC G++SR+V C ++++ C P+
Sbjct: 886 ------------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPR 932
Query: 426 MPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLC--IDHRG-MHTGGCSPKTKPH 481
P+ + C+ C P+W A +WS CT +CG GLR+RVVLC DHR + CSP KP
Sbjct: 933 PPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP 992
Query: 482 IKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVG 541
C + + P ++ W C+ CGVG
Sbjct: 993 ATMRCNL--------RRCP----------------------PARWVAGEWGECSAQCGVG 1022
Query: 542 TQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEIPEFNPDE 594
+ R VRC S EC E +P + + C A C P P+E
Sbjct: 1023 QRQRSVRC-------TSHTGQASHECTEALRPPTTQQCEA-KCDSPTPGDGPEE 1068
Score = 163 bits (412), Expect = 2e-39
Identities = 79/209 (37%), Positives = 106/209 (50%), Gaps = 7/209 (3%)
Query: 609 YDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
Y W Y +TKCS C GG Q V C N+ + C + P+ ++CN +PCP
Sbjct: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Query: 669 RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNC 728
W +G WS CS +C G+++R V C +S E L D C QP+P ++AC+ C
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAA--EEKALDDSACPQPRPPVLEACHGPTC 944
Query: 729 PPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDD 787
PP W W C+ +CG G++ R VLCK AD LP CS A+KP C
Sbjct: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHR-ATLPPAHCSPAAKPPATMRCNLRR 1001
Query: 788 C-PSEWLLSDWTECSTSCGEGTQTRSAIC 815
C P+ W+ +W ECS CG G + RS C
Sbjct: 1002 CPPARWVAGEWGECSAQCGVGQRQRSVRC 1030
Score = 150 bits (378), Expect = 1e-35
Identities = 96/283 (33%), Positives = 133/283 (46%), Gaps = 21/283 (7%)
Query: 1489 YWWSVDRLATCSASC-GNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Y W CSA C G VQ R L+S+ V P +C+ + + ACN CP
Sbjct: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
W+V +WS C+RSC GV++R V CQ+ ++ + + C Q RP +AC+ C
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ--PRPPVLEACHGPTC 944
Query: 1608 -VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD-GITLPSEQCSALPRPVSTQNCWSEA 1665
EWA W +C C GP L +HR V C++ D TLP CS +P +T C
Sbjct: 945 PPEWAALDWSECTPSC-GPGL--RHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRR 1001
Query: 1666 C-SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI-- 1722
C W W C+A CG G + R V C + T +A H C+ RP Q+C
Sbjct: 1002 CPPARWVAGEWGECSAQCG-VGQRQRSVRCT-SHTGQA--SHECTEALRPPTTQQCEAKC 1057
Query: 1723 ---TPCEN-MECRDTTR--YCEKVKQLKLCQLSQFKSRCCGTC 1759
TP + EC+D + YC V + + C + F+ CC TC
Sbjct: 1058 DSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 111 bits (277), Expect = 7e-24
Identities = 59/185 (31%), Positives = 85/185 (45%), Gaps = 15/185 (8%)
Query: 667 PARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELC--RQPKPSTVQACN 724
P W W+ CS C G Q + V C + L ++ +A C P +ACN
Sbjct: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQL-----DSSAVAPHYCSAHSKLPKRQRACN 880
Query: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
CPP W W CSR+C GV+ R V+C++R++ L ++ C +P +AC
Sbjct: 881 TEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACH 940
Query: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPC 844
CP EW DW+EC+ SCG G + R +C+ S +TL PP S + +P
Sbjct: 941 GPTCPPEWAALDWSECTPSCGPGLRHRVVLCK-------SADHRATL-PPAHCSPAAKPP 992
Query: 845 MLATC 849
C
Sbjct: 993 ATMRC 997
Score = 104 bits (259), Expect = 9e-22
Identities = 74/257 (28%), Positives = 101/257 (39%), Gaps = 37/257 (14%)
Query: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
W+ C+ C G+QV+ V C+ L S +VA P QRAC PC
Sbjct: 834 WTKCSAQCAGGSQVQAVECRNQLD-SSAVAP-HYCSAHSKLPKRQRACNTEPCPP----- 886
Query: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQT--REPAEENLC 648
DW ++ CS SC GV+ V C + + E A ++
Sbjct: 887 -------------------DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSA 927
Query: 649 VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILA 708
RPP +L++C+ CP W WS C+ +CG GL+ R V C + + L
Sbjct: 928 CPQPRPP-VLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLC-----KSADHRATLP 981
Query: 709 DELCRQP-KPSTVQACNRFNCPPA-WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
C KP CN CPPA W +W CS CG G ++R V C S E
Sbjct: 982 PAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASH-E 1040
Query: 767 LPETFCSASKPACQQAC 783
E + C+ C
Sbjct: 1041 CTEALRPPTTQQCEAKC 1057
Score = 94.4 bits (233), Expect = 9e-19
Identities = 72/285 (25%), Positives = 109/285 (38%), Gaps = 61/285 (21%)
Query: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKL 499
W W+ C+ C G + + V C + + + P C
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVEC---------------RNQLDSSAVAPHYC------- 866
Query: 500 PVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSV 559
+KLP ++A E P ++ WS C+ +C G + R V CQ +S ++
Sbjct: 867 SAHSKLPKRQRACNTEPCP-----PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEK 921
Query: 560 ADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKC 619
A L C P+P AC+ C E W +++C
Sbjct: 922 A-LDDSACPQPRPPVLEACHGPTCPPE------------------------WAALDWSEC 956
Query: 620 SESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP-ARWEIGKWSPC 678
+ SCG G++ VV C + R C + +PP ++ CNL CP ARW G+W C
Sbjct: 957 TPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMR-CNLRRCPPARWVAGEWGEC 1015
Query: 679 SLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQAC 723
S CGVG + R V C+ + T + E +P T Q C
Sbjct: 1016 SAQCGVGQRQRSVRCT-------SHTGQASHECTEALRPPTTQQC 1053
Score = 89.4 bits (220), Expect = 3e-17
Identities = 55/185 (29%), Positives = 75/185 (40%), Gaps = 13/185 (7%)
Query: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
P W W+ C+ C GG Q + V C+ S P C+ +K P +ACN +
Sbjct: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAP---HYCSAHSKLPKRQRACNTE 882
Query: 1606 LC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR----DGITLPSEQCSALPRPVSTQN 1660
C +W +W C+ C V+ R V CQ R + L C PRP +
Sbjct: 883 PCPPDWVVGNWSLCSRSC---DAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEA 938
Query: 1661 CWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRC 1720
C C W W+ CT +CG G + R V C A +P CS +P RC
Sbjct: 939 CHGPTCPPEWAALDWSECTPSCGP-GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
Query: 1721 NITPC 1725
N+ C
Sbjct: 998 NLRRC 1002
Score = 38.1 bits (87), Expect = 0.076
Identities = 31/122 (25%), Positives = 45/122 (36%), Gaps = 17/122 (13%)
Query: 679 SLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP-------- 730
S C G +++C +R + ++ A+ Q C + C P
Sbjct: 487 SRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGV 546
Query: 731 --AWYP-AQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
AW P W CSRTCGGGV R D + +C + ++C DD
Sbjct: 547 DGAWGPWTPWGDCSRTCGGGVSS-----SSRHCDSPRPTIGGKYCLGERRR-HRSCNTDD 600
Query: 788 CP 789
CP
Sbjct: 601 CP 602
Score = 35.4 bits (80), Expect = 0.49
Identities = 48/188 (25%), Positives = 59/188 (31%), Gaps = 58/188 (30%)
Query: 619 CSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA---------- 668
CS +CGGGV + C R C+ RR +SCN D CP
Sbjct: 559 CSRTCGGGVSSSSRHC--DSPRPTIGGKYCLGERRRH---RSCNTDDCPPGSQDFREVQC 613
Query: 669 --------RWEIGKW--------SPCSLTC---GVGLQTRDVFCSHLLSREMNETVILAD 709
R + KW CSLTC G T ++
Sbjct: 614 SEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTE------------RAAAVVDG 661
Query: 710 ELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPE 769
CR P TV C C + C R G + RE C+ DGS E E
Sbjct: 662 TPCR---PDTVDICVSGEC-------KHVGCDRVLGSDL--REDKCRVCGGDGSACETIE 709
Query: 770 TFCSASKP 777
S + P
Sbjct: 710 GVFSPASP 717
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 286 bits (733), Expect = 9e-77
Identities = 183/578 (31%), Positives = 266/578 (46%), Gaps = 99/578 (17%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W W W ECSRTCGGG S SLR C S K C G RYR+C+ CP +
Sbjct: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
Query: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
DFR +QC+ +++ G++Y W P + PC+L C A+G E AP V+DGT+C
Sbjct: 618 DFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA 677
Query: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
+SLD+CI+G C+ VGCD+ LGS +ED C VC GDGSTC + G + L + VV
Sbjct: 678 DSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYME-VV 736
Query: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG----TKGENSLSSTGTFLVDNSSVDFQKFPDK 262
IP GS HI + Y+ K+ +G G ++ F V ++ +++ D+
Sbjct: 737 QIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDE 795
Query: 263 -EILRMAGPLTADFI-----------------VKIRNSGSADSTVQFIFYQPIIHRWRET 304
E L GP + + I V I +GS D+ V F W
Sbjct: 796 PESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGF--------TWNHQ 847
Query: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
+ CSATC GG Q C L N +V + YC P++ KP + CN +PCP
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCD--PDS-KPPENQRACNTEPCP---- 900
Query: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTP 424
P W W CS +C GG+++RAV C+ + +++ C+ T
Sbjct: 901 -------------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-TH 946
Query: 425 KMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCID---HRGMHTGGCSPKTKP 480
+ +PCN C P+W+A +WS CT CG G ++R+VLC + C ++KP
Sbjct: 947 RPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKP 1006
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
++ C + + P P ++ W C+ CG+
Sbjct: 1007 PVRIRCSL--------------GRCP----------------PPRWVTGDWGQCSAQCGL 1036
Query: 541 GTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRAC 578
G Q+R V+C LS++ + D E +P S + C
Sbjct: 1037 GQQMRTVQC---LSYTGQASS---DCLETVRPPSMQQC 1068
Score = 150 bits (379), Expect = 1e-35
Identities = 74/217 (34%), Positives = 103/217 (47%), Gaps = 7/217 (3%)
Query: 601 GLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKS 660
G D + + W ++ +++CS +C GGVQ V C + N C +PP+ ++
Sbjct: 834 GSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRA 893
Query: 661 CNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV 720
CN +PCP W IG W CS TC G++TR V C + ET+ + C +P
Sbjct: 894 CNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSG--CLTHRPVEK 951
Query: 721 QACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKPAC 779
+ CN +CPP W W C+ CG G + R VLCK +F P C SKP
Sbjct: 952 EPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTF---PAAQCPEESKPPV 1008
Query: 780 QQACKKDDC-PSEWLLSDWTECSTSCGEGTQTRSAIC 815
+ C C P W+ DW +CS CG G Q R+ C
Sbjct: 1009 RIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC 1045
Score = 137 bits (346), Expect = 7e-32
Identities = 90/283 (31%), Positives = 134/283 (47%), Gaps = 22/283 (7%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
+ W+ + CSA+C GVQ+ + C L +++ V +C +P ACN CP
Sbjct: 842 FTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
W + W C+++C GG++TR V C ++ G S + D + RPV+ + CN Q
Sbjct: 901 PEWFIGDWLECSKTCDGGMRTRAVLC--IRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS 958
Query: 1607 C-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD-GITLPSEQCSALPRPVSTQNCWSE 1664
C +W W +C C GP +HR V C++ D T P+ QC +P C
Sbjct: 959 CPPQWVALDWSECTPKC-GP--GFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLG 1015
Query: 1665 AC-SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQ----R 1719
C W W C+A CG G Q R V+C+ + T +A + C RP + Q +
Sbjct: 1016 RCPPPRWVTGDWGQCSAQCG-LGQQMRTVQCL-SYTGQASSD--CLETVRPPSMQQCESK 1071
Query: 1720 CNITPCENM-ECRDTTR--YCEKVKQLKLCQLSQFKSRCCGTC 1759
C+ TP N EC+D + YC V + K C + F+ CC TC
Sbjct: 1072 CDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
Score = 115 bits (289), Expect = 3e-25
Identities = 57/185 (30%), Positives = 85/185 (45%), Gaps = 10/185 (5%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPK--PSTVQACNRFN 727
W WS CS TC G+Q ++V C L ++ I+ + C P +ACN
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRL-----DDNSIVQNNYCDPDSKPPENQRACNTEP 898
Query: 728 CPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
CPP W+ W CS+TC GG++ R VLC +++ L + C +P ++ C
Sbjct: 899 CPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS 958
Query: 788 CPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLA 847
CP +W+ DW+EC+ CG G + R +C+ + LS + CP C L
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCK---SSDLSKTFPAAQCPEESKPPVRIRCSLG 1015
Query: 848 TCARP 852
C P
Sbjct: 1016 RCPPP 1020
Score = 101 bits (252), Expect = 6e-21
Identities = 78/276 (28%), Positives = 111/276 (40%), Gaps = 43/276 (15%)
Query: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
+ WS C+ TC G Q + V C+ L S+ + + P +QRAC PC E
Sbjct: 847 QPWSECSATCAGGVQRQEVVCKRL--DDNSIVQNNYCDPDSKPPENQRACNTEPCPPE-- 902
Query: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK---QTREPAEE 645
W + +CS++C GG++ V C+ K E +
Sbjct: 903 ----------------------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDY 940
Query: 646 NLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETV 705
+ C+T R P + CN CP +W WS C+ CG G + R V C S ++++T
Sbjct: 941 SGCLTHR--PVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCK---SSDLSKT- 994
Query: 706 ILADELCRQPKPSTVQACNRFNC-PPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSF 764
A + + KP C+ C PP W W CS CG G Q R V C S
Sbjct: 995 FPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS- 1053
Query: 765 LELPETFCSASKPACQQACKKDDCPSEWLLSDWTEC 800
+ ET S C+ C D P +S+ EC
Sbjct: 1054 SDCLETVRPPSMQQCESKC--DSTP----ISNTEEC 1083
Score = 38.5 bits (88), Expect = 0.058
Identities = 21/72 (29%), Positives = 28/72 (38%), Gaps = 2/72 (2%)
Query: 1655 PVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRP 1714
P++ W W+ C+ATC G Q + V C N V + C +P
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKP 887
Query: 1715 ANWQR-CNITPC 1725
QR CN PC
Sbjct: 888 PENQRACNTEPC 899
Score = 37.0 bits (84), Expect = 0.17
Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 20/91 (21%)
Query: 578 CYAGPCSGEIPEFN-PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLN 636
CY G C +P P DG +G W G +CS +CGGGV ++ C
Sbjct: 542 CYQGDC---VPFGTWPQSIDGGWG---------PWSLWG--ECSRTCGGGVSSSLRHC-- 585
Query: 637 KQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
C+ R+ +SCN DPCP
Sbjct: 586 DSPAPSGGGKYCLGERK---RYRSCNTDPCP 613
Score = 36.6 bits (83), Expect = 0.22
Identities = 30/127 (23%), Positives = 47/127 (37%), Gaps = 17/127 (13%)
Query: 674 KWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP--- 730
++ S C G R+++C +R + ++ A+ Q C + +C P
Sbjct: 493 QYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGT 552
Query: 731 -------AWYP-AQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQA 782
W P + W CSRTCGGGV C G +C + ++
Sbjct: 553 WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGG-----GKYCLGERKR-YRS 606
Query: 783 CKKDDCP 789
C D CP
Sbjct: 607 CNTDPCP 613
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 279 bits (714), Expect = 2e-74
Identities = 207/666 (31%), Positives = 289/666 (43%), Gaps = 103/666 (15%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
G W W WS CSRTCGGG S+ R C + K CEG + C++ CP ++ D
Sbjct: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646
Query: 88 FRAQQCSAHNDVKHHGQFYEWLPVSNDPDNP-CSLKCQAKGTTLVVELAPKVLDGTRCYT 146
FRA QC+ HN + G+ Y+W P + D C L C A+G L+ KV DGT C
Sbjct: 647 FRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSE 706
Query: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
+S ++CI G+C+ VGCD+ LGS ED CGVCNG+ S C + RG Y ++ T +V
Sbjct: 707 DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY-TKHHHTNQYYHMV 765
Query: 207 AIPYGSRHIRLVLKGPDHLYLETKTL---QGTKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
IP G+R IR+ Y+ + G ++ G + ++ D+++ + +
Sbjct: 766 TIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEP 825
Query: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFP----------CSAT 312
E L GP IV++ G + V + + P + ++ P CS +
Sbjct: 826 ENLIATGPTNETLIVELLFQG-RNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVS 884
Query: 313 CGGGYQLTSAECY-DLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPY 371
CGGG CY DL+ V +C+ +P L C + CP
Sbjct: 885 CGGGQMTVREGCYRDLKFQ--VNMSFCN---PKTRPVTGLVPCKVSACP----------- 928
Query: 372 DLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQP 431
P W W+ACS +CGGG QSR V C + V C P Q
Sbjct: 929 ------PSWSVGNWSACSRTCGGGAQSRPVQCTRR-VHYDSEPVPASLCP-QPAPSSRQA 980
Query: 432 CNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG------MHTGGCSPKTKPHIKE 484
CN C P W A W+ C+ TCG+G R R V C + C+ + KP + E
Sbjct: 981 CNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
Query: 485 ECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQV 544
C++ C+KPK KL W + AWS C+VTC GTQ
Sbjct: 1041 ACLLQR-CHKPK-------KLQW-------------------LVSAWSQCSVTCERGTQK 1073
Query: 545 RIVRCQVLLSFSQSVADLPIDECEG-PKPA--SQRACYAGPCSGEIPEFNPDETDGLFGG 601
R ++C S +L +C PKP+ +RAC PC P P G G
Sbjct: 1074 RFLKCAEKY-VSGKYRELASKKCSHLPKPSLELERACAPLPC----PRHPPFAAAGPSRG 1128
Query: 602 LQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSC 661
W +++C+ SCGGGVQ V CL PA C+ ++P L +C
Sbjct: 1129 --------SWFASPWSQCTASCGGGVQTRSVQCL--AGGRPASG--CLLHQKPSASL-AC 1175
Query: 662 NLDPCP 667
N CP
Sbjct: 1176 NTHFCP 1181
Score = 157 bits (398), Expect = 7e-38
Identities = 90/254 (35%), Positives = 118/254 (46%), Gaps = 14/254 (5%)
Query: 617 TKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWS 676
++CS SCGGG C + + + C RP L C + CP W +G WS
Sbjct: 879 SECSVSCGGGQMTVREGCY-RDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWS 937
Query: 677 PCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQ 736
CS TCG G Q+R V C+ R ++ + LC QP PS+ QACN +CPPAW
Sbjct: 938 ACSRTCGGGAQSRPVQCTR---RVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGP 994
Query: 737 WQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKPACQQACKKDDCPS----E 791
W CS TCG G +KR V CK LP+ C S KP +AC C +
Sbjct: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQ 1054
Query: 792 WLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR 851
WL+S W++CS +C GTQ R C + +G + S C LP +P + A
Sbjct: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP-----KPSLELERAC 1109
Query: 852 PGRPSTKHSPHIAA 865
P +H P AA
Sbjct: 1110 APLPCPRHPPFAAA 1123
Score = 129 bits (324), Expect = 3e-29
Identities = 75/227 (33%), Positives = 101/227 (44%), Gaps = 26/227 (11%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNK--QTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
W ++ CS +CGGG Q V C + EP +LC + P ++CN CP
Sbjct: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC--PQPAPSSRQACNSQSCPP 988
Query: 669 RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACNRFN 727
W G W+ CS TCG G + R V C + +L D +C +PKP +AC
Sbjct: 989 AWSAGPWAECSHTCGKGWRKRAVACKS--TNPSARAQLLPDAVCTSEPKPRMHEACLLQR 1046
Query: 728 CPPA----WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQ-- 780
C W + W CS TC G QKR + C ++ G + EL CS KP+ +
Sbjct: 1047 CHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELE 1106
Query: 781 QACKKDDCP------------SEWLLSDWTECSTSCGEGTQTRSAIC 815
+AC CP W S W++C+ SCG G QTRS C
Sbjct: 1107 RACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
Score = 118 bits (296), Expect = 4e-26
Identities = 77/240 (32%), Positives = 113/240 (47%), Gaps = 22/240 (9%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLN-STEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Y W++ R + CS SCG G R C + +VN + C K RP + C CP
Sbjct: 872 YTWAIVR-SECSVSCGG-GQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPP 929
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
W V +WSAC+R+CGGG Q+R V C + + S PV +C Q A P QACN Q C
Sbjct: 930 SWSVGNWSACSRTCGGGAQSRPVQCTR-RVHYDSEPVPASLCPQPA--PSSRQACNSQSC 986
Query: 1608 -VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD----GITLPSEQCSALPRPVSTQNCW 1662
W+ W +C+ C + R V C++ + LP C++ P+P + C
Sbjct: 987 PPAWSAGPWAECSHTC---GKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACL 1043
Query: 1663 SEAC----SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTN---KAVPEHLCSWGPRPA 1715
+ C + W VS W+ C+ TC G Q R ++C + + + CS P+P+
Sbjct: 1044 LQRCHKPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Score = 117 bits (293), Expect = 1e-25
Identities = 87/303 (28%), Positives = 129/303 (42%), Gaps = 42/303 (13%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLN---STEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
WSV + CS +CG G Q ++C +E PA + P+ + ACN + CP
Sbjct: 931 WSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQ-ACNSQSCPP 988
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
W W+ C+ +CG G + R V C+ S + + + +CT K P +AC Q C
Sbjct: 989 AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPK-PRMHEACLLQRC 1047
Query: 1608 -----VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR----DGITLPSEQCSALPRPVST 1658
++W S+W QC+ C Q R + C + L S++CS LP+P
Sbjct: 1048 HKPKKLQWLVSAWSQCSVTC---ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLE 1104
Query: 1659 --QNCWSEACSVH------------WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVP 1704
+ C C H W S W+ CTA+CG G Q+R V+C+ P
Sbjct: 1105 LERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQCLAGGR----P 1159
Query: 1705 EHLCSWGPRPANWQRCNITPCENME-----CRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
C +P+ CN C E C+D +C V Q +C + +CC TC
Sbjct: 1160 ASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTC 1219
Query: 1760 GKA 1762
K+
Sbjct: 1220 SKS 1222
Score = 110 bits (276), Expect = 9e-24
Identities = 84/290 (28%), Positives = 120/290 (41%), Gaps = 61/290 (21%)
Query: 524 PSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPC 583
PS+ WSAC+ TCG G Q R V+C + + +P C P P+S++AC + C
Sbjct: 929 PSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSE--PVPASLCPQPAPSSRQACNSQSC 986
Query: 584 SGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC--LNKQTRE 641
W + +CS +CG G ++ V+C N R
Sbjct: 987 PPA------------------------WSAGPWAECSHTCGKGWRKRAVACKSTNPSARA 1022
Query: 642 PAEENLCVTSRRPPQLLKSCNLDPC----PARWEIGKWSPCSLTCGVGLQTRDVFCSH-L 696
+ TS P++ ++C L C +W + WS CS+TC G Q R + C+
Sbjct: 1023 QLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKY 1082
Query: 697 LSREMNETVILADELCRQ-PKPSTV--QACNRFNCPP------------AWYPAQWQPCS 741
+S + E LA + C PKPS +AC CP +W+ + W C+
Sbjct: 1083 VSGKYRE---LASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCT 1139
Query: 742 RTCGGGVQKREVLCKQ--RMADGSFLELPETFCSASKPACQQACKKDDCP 789
+CGGGVQ R V C R A G L KP+ AC CP
Sbjct: 1140 ASCGGGVQTRSVQCLAGGRPASGCLLH--------QKPSASLACNTHFCP 1181
Score = 90.9 bits (224), Expect = 1e-17
Identities = 94/365 (25%), Positives = 132/365 (36%), Gaps = 83/365 (22%)
Query: 388 CSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM-PIAQ--PCNIFDCP-KWLAQ 443
CS SCGGG + C D++ V PK P+ PC + CP W
Sbjct: 881 CSVSCGGGQMTVREGCYR-DLKFQVNM-----SFCNPKTRPVTGLVPCKVSACPPSWSVG 934
Query: 444 EWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEA 503
WS C+ TCG G + R V C + H E + + C +P
Sbjct: 935 NWSACSRTCGGGAQSRPVQCT-------------RRVHYDSEPVPASLCPQPA------- 974
Query: 504 KLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLP 563
P +QA + S P++ W+ C+ TCG G + R V C+ +++ LP
Sbjct: 975 --PSSRQACNSQ-----SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL-LP 1026
Query: 564 IDECEG-PKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSES 622
C PKP AC C + W +++CS +
Sbjct: 1027 DAVCTSEPKPRMHEACLLQRCHKP--------------------KKLQWLVSAWSQCSVT 1066
Query: 623 CGGGVQEAVVSCLNKQT----REPAEENLCVTSRRPPQLLKSCNLDPCPAR--------- 669
C G Q+ + C K RE A + + +L ++C PCP
Sbjct: 1067 CERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPS 1126
Query: 670 ---WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRF 726
W WS C+ +CG G+QTR V C L +L KPS ACN
Sbjct: 1127 RGSWFASPWSQCTASCGGGVQTRSVQC--LAGGRPASGCLL------HQKPSASLACNTH 1178
Query: 727 NCPPA 731
CP A
Sbjct: 1179 FCPIA 1183
Score = 39.3 bits (90), Expect = 0.034
Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 8/58 (13%)
Query: 735 AQWQPCSRTCGGGVQKREVLC-KQRMADGSFLELPETFCSASKPACQQACKKDDCPSE 791
+ W PCSRTCGGGV R LC + + G FC S + C CP +
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPSHGG------KFCEGSTRTL-KLCNSQKCPRD 643
Score = 34.7 bits (78), Expect = 0.84
Identities = 23/77 (29%), Positives = 27/77 (35%), Gaps = 31/77 (40%)
Query: 665 PCPARW-EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPS----- 718
P W + WSPCS TCG G+ R LC PKPS
Sbjct: 584 PTHGHWSDWSSWSPCSRTCGGGVSHR-------------------SRLCTNPKPSHGGKF 624
Query: 719 ------TVQACNRFNCP 729
T++ CN CP
Sbjct: 625 CEGSTRTLKLCNSQKCP 641
Score = 34.3 bits (77), Expect = 1.1
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 1552 TSWSACTRSCGGGVQTRRVTCQKLKAS 1578
+SWS C+R+CGGGV R C K S
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPS 619
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 275 bits (704), Expect = 2e-73
Identities = 197/671 (29%), Positives = 293/671 (43%), Gaps = 117/671 (17%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
G W AW WSECSRTCGGG + R C + K C G + Y+ C+ C + D
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649
Query: 88 FRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
FRAQQC+ +N G FY+W P + + ++ C L C+A+ ++ KV DGT C
Sbjct: 650 FRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSP 709
Query: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
D+CI G+C++VGCDH+LGS D CGVC GD STC+ +G Y +Q A + VV
Sbjct: 710 NKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEY-YPVV 768
Query: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
IP G+R I + YL ++L G S+ G F ++ ++Q+ F
Sbjct: 769 LIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRP 828
Query: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------------HRWRETDFFPCS 310
E L GP + +I G + + + + P + + W CS
Sbjct: 829 ERLYAPGPTNETLVFEILMQGK-NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECS 886
Query: 311 ATCGGGYQLTSAECYDLR-SNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM 369
+CGGGY A C LR N V +C KP + + CN CPA
Sbjct: 887 VSCGGGYINVKAIC--LRDQNTQVNSSFC---SAKTKPVTEPKICNAFSCPA-------- 933
Query: 370 PYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKMPI 428
W W+ CS +C GG QSR + CV++ +V C + TP
Sbjct: 934 ---------YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ-- 982
Query: 429 AQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEE 485
Q CN C P+W WS C+ TCG+G+R R +LC + C+ +P ++E
Sbjct: 983 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG 1042
Query: 486 CIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVR 545
C++ + P ++L W + +WS C+ TCG+G + R
Sbjct: 1043 CVL--------GRCPKNSRLQW-------------------VASSWSECSATCGLGVRKR 1075
Query: 546 IVRCQVLLSFSQSVADLPIDECEGPK--------PASQRACYAGPCSGEIPEFNPDETDG 597
++C F + P C K ++RAC A P
Sbjct: 1076 EMKCSE-KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPV-------------- 1120
Query: 598 LFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQL 657
++ + W + +C+ +CGGGVQ V C+ Q P+ C+ ++PP +
Sbjct: 1121 -------YNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--QQGRPSSS--CLLHQKPP-V 1168
Query: 658 LKSCNLDPCPA 668
L++CN + CPA
Sbjct: 1169 LRACNTNFCPA 1179
Score = 150 bits (380), Expect = 8e-36
Identities = 79/204 (38%), Positives = 102/204 (50%), Gaps = 12/204 (5%)
Query: 617 TKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWS 676
++CS SCGGG CL Q + + C +P K CN CPA W G+WS
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQ-VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWS 941
Query: 677 PCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQ 736
CS C G Q+R + C + E V+ LC P+ VQACN CPP W
Sbjct: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVL--HSLCPVSTPTQVQACNSHACPPQWSLGP 999
Query: 737 WQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKPACQQACKKDDCPS----E 791
W CS+TCG GV+KRE+LCK A+ LPE+ C S +P Q+ C CP +
Sbjct: 1000 WSQCSKTCGRGVRKRELLCKGSAAE----TLPESQCTSLPRPELQEGCVLGRCPKNSRLQ 1055
Query: 792 WLLSDWTECSTSCGEGTQTRSAIC 815
W+ S W+ECS +CG G + R C
Sbjct: 1056 WVASSWSECSATCGLGVRKREMKC 1079
Score = 138 bits (348), Expect = 4e-32
Identities = 69/211 (32%), Positives = 106/211 (50%), Gaps = 12/211 (5%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSR 1548
Y WS+ + + CS SCG + + +T+VN + C+ K +P +P CN CP+
Sbjct: 876 YTWSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY 934
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC- 1607
WM WS C+++C GG Q+R++ C + K V + +C P QACN C
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP--VSTPTQVQACNSHACP 992
Query: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC- 1666
+W+ W QC+ C V+ R++ C+ TLP QC++LPRP + C C
Sbjct: 993 PQWSLGPWSQCSKTC---GRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCP 1049
Query: 1667 ---SVHWRVSLWTLCTATCGNYGFQSRRVEC 1694
+ W S W+ C+ATCG G + R ++C
Sbjct: 1050 KNSRLQWVASSWSECSATCG-LGVRKREMKC 1079
Score = 135 bits (341), Expect = 3e-31
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 32/260 (12%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNK---QTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
W ++ CS++C GG Q + C+ K Q E +LC S P +++CN CP
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST--PTQVQACNSHACP 992
Query: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFN 727
+W +G WS CS TCG G++ R++ C + + E+ + P+P + C
Sbjct: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPES-----QCTSLPRPELQEGCVLGR 1047
Query: 728 CPP----AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKP--ACQ 780
CP W + W CS TCG GV+KRE+ C ++ G + PE C + KP +
Sbjct: 1048 CPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLE 1107
Query: 781 QACKKDDCPSE--------WLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC 832
+ C + CP+ W W +C+ +CG G QTRS C + + S +++
Sbjct: 1108 ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQK-- 1165
Query: 833 PPLPFSSSIRPCMLATCARP 852
PP+ +R C C P
Sbjct: 1166 PPV-----LRACNTNFCPAP 1180
Score = 108 bits (271), Expect = 4e-23
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 11/186 (5%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV-QACNRFNC 728
W I + S CS++CG G C + ++N + A + KP T + CN F+C
Sbjct: 878 WSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSFCSA-----KTKPVTEPKICNAFSC 931
Query: 729 PPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDC 788
P W P +W CS+ C GG Q R++ C Q+ + + C S P QAC C
Sbjct: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
Query: 789 PSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLAT 848
P +W L W++CS +CG G + R +C K + + + C LP C+L
Sbjct: 992 PPQWSLGPWSQCSKTCGRGVRKRELLC----KGSAAETLPESQCTSLPRPELQEGCVLGR 1047
Query: 849 CARPGR 854
C + R
Sbjct: 1048 CPKNSR 1053
Score = 76.6 bits (187), Expect = 2e-13
Identities = 55/191 (28%), Positives = 81/191 (42%), Gaps = 23/191 (12%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNP-AHCAGKVRPAVQPIACNRRDCPS-- 1547
WS+ + CS +CG RGV++ L C ++ E P + C RP +Q C CP
Sbjct: 995 WSLGPWSQCSKTCG-RGVRKRELLCKGSAAETLPESQCTSLPRPELQE-GCVLGRCPKNS 1052
Query: 1548 --RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVD-TQACNQ 1604
+W+ +SWS C+ +CG GV+ R + C + G C + K +D + CN+
Sbjct: 1053 RLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNR 1112
Query: 1605 QLC---------VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRP 1655
+ C W W QC C G VQ R V C + PS C +P
Sbjct: 1113 RACPAHPVYNMVAGWYSLPWQQCTVTCGG---GVQTRSVHCVQQG---RPSSSCLLHQKP 1166
Query: 1656 VSTQNCWSEAC 1666
+ C + C
Sbjct: 1167 PVLRACNTNFC 1177
Score = 36.6 bits (83), Expect = 0.22
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W + C+ TCGGG Q S C ++ R + H P P L+ CN + CP
Sbjct: 1127 WYSLPWQQCTVTCGGGVQTRSVHC--VQQGRPSSSCLLHQKP------PVLRACNTNFCP 1178
Query: 361 ASD 363
A +
Sbjct: 1179 APE 1181
Score = 33.5 bits (75), Expect = 1.9
Identities = 14/25 (56%), Positives = 18/25 (72%), Gaps = 2/25 (8%)
Query: 731 AWYPAQWQPCSRTCGGGVQKREVLC 755
AW ++W CSRTCGGGV+ +E C
Sbjct: 594 AW--SKWSECSRTCGGGVKFQERHC 616
Score = 33.1 bits (74), Expect = 2.5
Identities = 31/114 (27%), Positives = 46/114 (40%), Gaps = 17/114 (14%)
Query: 596 DGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCL---------NKQTREPAEEN 646
D L G + D D W++ K C G + + L + AE
Sbjct: 508 DKLPGQIYDADTQCKWQFGAKAKL---CSLGFVKDICKSLWCHRVGHRCETKFMPAAEGT 564
Query: 647 LCVTSR--RPPQLLKSCNLDPCP--ARWEI-GKWSPCSLTCGVGLQTRDVFCSH 695
+C S R Q +K L P P +W KWS CS TCG G++ ++ C++
Sbjct: 565 VCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNN 618
Score = 31.6 bits (70), Expect = 7.1
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 9/76 (11%)
Query: 1547 SRWMVTSWSACTRSCGGGV--QTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACN- 1603
S W + WS C+R+CGGGV Q R K + G+ P S+ + P + + +
Sbjct: 593 SAW--SKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDF 650
Query: 1604 -QQLCVEW---AFSSW 1615
Q C E+ F W
Sbjct: 651 RAQQCAEYNSKPFRGW 666
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 275 bits (703), Expect = 3e-73
Identities = 181/594 (30%), Positives = 269/594 (45%), Gaps = 100/594 (16%)
Query: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC----LSSKSCEGRNIRYRTCS 77
+SRT+ E L W WS CSRTC G S R+C ++ C G +YR C
Sbjct: 626 TSRTSAPEH----LAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE 681
Query: 78 NVDCPPEAGDFRAQQCSAHN----DVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVE 133
N CP FR QC A++ KH +W V D + PC+L C G +
Sbjct: 682 NPPCPAGLPGFRDWQCQAYSVRTSSPKH---ILQWQAVL-DEEKPCALFCSPVGKEQPIL 737
Query: 134 LAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
L+ KV+DGT C + LD+C +G CQ VGCD LGS +ED+CGVCNG+G +C++++G +
Sbjct: 738 LSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFN 797
Query: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTL--QGTKGENSLSSTGTFLVDN 251
A + V+ IP G+R I++V + P H YL + Q + + +G F +
Sbjct: 798 HTRGAGYVE--VLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAG 855
Query: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPI-------------- 297
++V + + E + GP TA + + + + + + P
Sbjct: 856 TTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEP 915
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV--VADQYCHYYPENIKPKPKLQECN 355
+ W T + C ATCGGG + T+ C + S + V ++ C Y KP+P++++CN
Sbjct: 916 LFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT---KPEPQIRKCN 972
Query: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
PC RW T WT CS +CG G+QSR V+C ++ G +
Sbjct: 973 EQPCQT-----------------RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRA 1015
Query: 416 EEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
E C+ PK AQ C DC W A WS C+V CG+G+R+R V C + R C
Sbjct: 1016 RERDCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKK----C 1070
Query: 475 SPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSAC 534
T+P E+C + CY + WS C
Sbjct: 1071 VLSTRPREAEDCEDYSKCYVWRMG-------------------------------DWSKC 1099
Query: 535 TVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEI 587
++TCG G Q R+++C + +EC KPA+ R C+ PC+ +I
Sbjct: 1100 SITCGKGMQSRVIQCM------HKITGRHGNECFSSEKPAAYRPCHLQPCNEKI 1147
Score = 142 bits (359), Expect = 2e-33
Identities = 82/264 (31%), Positives = 123/264 (46%), Gaps = 22/264 (8%)
Query: 606 DELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPA--EENLCVTSRRPPQLLKSCNL 663
+ L+ W + + C +CGGG ++ VSC ++ + + C +P ++ CN
Sbjct: 914 EPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNE 973
Query: 664 DPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADEL-CRQPKPSTVQA 722
PC RW + +W+PCS TCG G+Q+R V C+ LS N T+I A E C PKP++ Q
Sbjct: 974 QPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS---NGTLIRARERDCIGPKPASAQR 1030
Query: 723 CNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQ 781
C +C W W CS CG G++ R V C P C S +P +
Sbjct: 1031 CEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN----------PRKKCVLSTRPREAE 1080
Query: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
C+ W + DW++CS +CG+G Q+R C + T + C ++
Sbjct: 1081 DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKI-----TGRHGNECFSSEKPAAY 1135
Query: 842 RPCMLATCARPGRPSTKHSPHIAA 865
RPC L C +T SP +AA
Sbjct: 1136 RPCHLQPCNEKINVNTITSPRLAA 1159
Score = 139 bits (349), Expect = 3e-32
Identities = 83/294 (28%), Positives = 134/294 (45%), Gaps = 38/294 (12%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLL----NSTEVNPAHCAGKVRPAVQPIACNRRD 1544
+ W+ C A+CG G ++ + C N + V+ C +P Q CN +
Sbjct: 917 FMWTHTSWEDCDATCGG-GERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQP 975
Query: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
C +RWM+T W+ C+R+CG G+Q+R+V C + ++G C + +P Q C
Sbjct: 976 CQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC--IGPKPASAQRCEG 1033
Query: 1605 QLCVE-WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
Q C+ W W +C+ C ++HR V C T P ++C RP ++C
Sbjct: 1034 QDCMTVWEAGVWSECSVKC---GKGIRHRTVRC------TNPRKKCVLSTRPREAEDCED 1084
Query: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
+ WR+ W+ C+ TCG G QSR ++C+H T + E C +PA ++ C++
Sbjct: 1085 YSKCYVWRMGDWSKCSITCGK-GMQSRVIQCMHKITGRHGNE--CFSSEKPAAYRPCHLQ 1141
Query: 1724 PC-ENMECRDTTR-----------------YCEKVKQLKLCQLSQFKSRCCGTC 1759
PC E + T YC +++ LCQ ++ RCC TC
Sbjct: 1142 PCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
Score = 107 bits (268), Expect = 8e-23
Identities = 88/313 (28%), Positives = 129/313 (41%), Gaps = 74/313 (23%)
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
DP P + K PL W T W C ++CGGG + VSC + + +++ V+
Sbjct: 902 DPLPENQSSKAP------EPLFMWTHTSWEDCDATCGGGERKTTVSCTKI-MSKNISIVD 954
Query: 417 EWKCMYTPKM-PIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
KC Y K P + CN C +W+ EW+PC+ TCG+G++ R V C T
Sbjct: 955 NEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVAC-------TQQL 1007
Query: 475 SPKTKPHIKE-ECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSA 533
S T +E +CI P P AQ E ++ + + WS
Sbjct: 1008 SNGTLIRARERDCIGPKPA-----------------SAQRCEGQDCMTVWEAGV---WSE 1047
Query: 534 CTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPD 593
C+V CG G + R VRC P +C S R A C
Sbjct: 1048 CSVKCGKGIRHRTVRCTN-----------PRKKCV----LSTRPREAEDC---------- 1082
Query: 594 ETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR 653
+D+ + Y W ++KCS +CG G+Q V+ C++K T E C +S +
Sbjct: 1083 ---------EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE--CFSSEK 1131
Query: 654 PPQLLKSCNLDPC 666
P + C+L PC
Sbjct: 1132 -PAAYRPCHLQPC 1143
Score = 36.6 bits (83), Expect = 0.22
Identities = 38/159 (23%), Positives = 55/159 (34%), Gaps = 50/159 (31%)
Query: 645 ENLCVTSRRPPQ------LLKSCNLDPCPARW--------EIGKWSPCSLTCGVGLQTRD 690
E C T PP L K C C +R E WSPCS TC G+ +R+
Sbjct: 598 EKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRE 657
Query: 691 VFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPA------W------------ 732
C L S + C P+ + C CP W
Sbjct: 658 RKCPGLDSEARD---------CNGPR-KQYRICENPPCPAGLPGFRDWQCQAYSVRTSSP 707
Query: 733 -YPAQWQ-------PCSRTCGGGVQKREVLCKQRMADGS 763
+ QWQ PC+ C +++ +L +++ DG+
Sbjct: 708 KHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGT 746
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 265 bits (678), Expect = 2e-70
Identities = 182/603 (30%), Positives = 259/603 (42%), Gaps = 102/603 (16%)
Query: 13 LLFLAFLLLSSRTARSEEDRDGLWDAWGPWSE---CSRTCGGGASYSLRRCLSSK----- 64
LL L LLL+ S D WGPWS+ CSRTCGGG S+ R C S +
Sbjct: 3 LLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGS 62
Query: 65 SCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQ 124
SC G +R+C CP A DFRA+QC+ + + G+ Y WLP + P N C L C
Sbjct: 63 SCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAP-NKCELNCI 121
Query: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
KG + V+DGT C D+C+ G C++VGCDH+L S+ +ED C C GDG+T
Sbjct: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
Query: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSST 244
C V G + + +++ V Y + H + + +L +
Sbjct: 182 CYPVAGTFDAN-DLSRAVKNVRGEYYLNGHWTI------------------EAARALPAA 222
Query: 245 GTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH----- 299
T L + P++ L GP + ++++ S + V + ++ P+
Sbjct: 223 STILHYERGAEGDLAPER--LHARGPTSEPLVIEL-ISQEPNPGVHYEYHLPLRRPSPGF 279
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
W + CSA CGGG+Q C + D C P +P + + CNL PC
Sbjct: 280 SWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQP---RPADR-RSCNLHPC 333
Query: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
P + RW+A PW CS+SCGGG QSR+V C+ D G +VEE +
Sbjct: 334 PET---------------KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAE 378
Query: 420 CMYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSP 476
C P K P Q CN+ C W + W C+V+CG G+R R V C RG +HT CS
Sbjct: 379 CAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSL 438
Query: 477 KTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTV 536
+ +P + E C+ E P+ + W W C+
Sbjct: 439 EDRPPLTEPCV--------HEDCPLLSDQAWH-------------------VGTWGLCSK 471
Query: 537 TCGVGTQVRIVRCQVLLSFSQSVADLPIDEC---EGPKPASQRACYAGPCSGEIPEFNPD 593
+C GT+ R V C + P C + KP C PC +P+ P
Sbjct: 472 SCSSGTRRRQVICAI----------GPPSHCGSLQHSKPVDVEPCNTQPC--HLPQEVPS 519
Query: 594 ETD 596
D
Sbjct: 520 MQD 522
Score = 148 bits (373), Expect = 5e-35
Identities = 150/552 (27%), Positives = 209/552 (37%), Gaps = 75/552 (13%)
Query: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
L P P S K D + P W + W+ CS +CGGG+ R C + G + V
Sbjct: 11 LAPAPGSSAPKVRRQSDTWGP---W--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
Query: 416 EEWKCMYTPKMPIAQPCNIFDCPK----WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT 471
+ + C CP + A++ + QG RYR +
Sbjct: 66 GPARSH--------RSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCE 117
Query: 472 GGCSPKTKPHI---KEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIP 528
C PK + +E + TPC K + V+ EL+ +E +
Sbjct: 118 LNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSS---KQEDKCLR 174
Query: 529 EAWSACTVTCGVGT--------QVRIVRCQVLLSFS---QSVADLPIDE--------CEG 569
T GT V+ VR + L+ ++ LP EG
Sbjct: 175 CGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEG 234
Query: 570 PKPASQRACYAGPCSGEI------PEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESC 623
A +R GP S + E NP L+ + W + ++ CS C
Sbjct: 235 DL-APERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAEC 293
Query: 624 GGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA--RWEIGKWSPCSLT 681
GGG Q +V C P +++C RP +SCNL PCP RW+ G W+PCS +
Sbjct: 294 GGGHQSRLVFCTIDHEAYP--DHMCQRQPRPADR-RSCNLHPCPETKRWKAGPWAPCSAS 350
Query: 682 CGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCS 741
CG G Q+R V+C + E V A+ KP +QACN C AW P W CS
Sbjct: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECS 409
Query: 742 RTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDCP----SEWLLSD 796
+CG GV+KR V C R GS L CS +P + C +DCP W +
Sbjct: 410 VSCGVGVRKRSVTC--RGERGSLLH--TAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGT 465
Query: 797 WTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSS--SIRPCMLATCARPGR 854
W CS SC GT+ R IC + + C L S + PC C P
Sbjct: 466 WGLCSKSCSSGTRRRQVIC---------AIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQE 516
Query: 855 PSTKHSPHIAAA 866
+ H A+
Sbjct: 517 VPSMQDVHTPAS 528
Score = 127 bits (319), Expect = 1e-28
Identities = 83/243 (34%), Positives = 110/243 (45%), Gaps = 20/243 (8%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAH-CAGKVRPAVQPIACNRRDCPS-- 1547
WS + CSA CG G Q RL E P H C + RPA + +CN CP
Sbjct: 281 WSHGSWSDCSAECG--GGHQSRLVFCTIDHEAYPDHMCQRQPRPADRR-SCNLHPCPETK 337
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
RW W+ C+ SCGGG Q+R V C +GI V C + +P QACN Q C
Sbjct: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Query: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACS 1667
W+ WG+C+ C + V+ R V C+ G L + CS RP T+ C E C
Sbjct: 398 AAWSPEPWGECSVSC---GVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCP 454
Query: 1668 V----HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCS-WGPRPANWQRCNI 1722
+ W V W LC+ +C + G + R+V C P H S +P + + CN
Sbjct: 455 LLSDQAWHVGTWGLCSKSCSS-GTRRRQVICA-----IGPPSHCGSLQHSKPVDVEPCNT 508
Query: 1723 TPC 1725
PC
Sbjct: 509 QPC 511
Score = 77.8 bits (190), Expect = 9e-14
Identities = 59/186 (31%), Positives = 87/186 (46%), Gaps = 22/186 (11%)
Query: 1192 ASGTLSVLLHCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCN 1251
AS + + C A G P P I W R+G+ V S R LQPD SL I D GFYTC
Sbjct: 1028 ASPGQRIRMTCRAEGFPPPAIEWQRDGQPVS-SPRHQLQPDGSLVISRVAVEDGGFYTCV 1086
Query: 1252 ATNALGYDSVSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVA 1311
A N D + + + G+ I+ P VTV G T + + C VA
Sbjct: 1087 AFNGQDRDQRWVQLRVLGE--------LTISGLPPTVTVPEGDTARLL--------CVVA 1130
Query: 1312 GVPEAEVTWFRNKSKLGSP-HHLHE---GSLLLTNVSSSDQGLYSCRAANLHGELTESTQ 1367
G + W RN + + H +H+ G+LL+ N+ + D+G Y+C A ++ ST+
Sbjct: 1131 G-ESVNIRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTE 1189
Query: 1368 LLILDP 1373
+ ++ P
Sbjct: 1190 VKVVSP 1195
Score = 74.3 bits (181), Expect = 1e-12
Identities = 94/354 (26%), Positives = 137/354 (38%), Gaps = 75/354 (21%)
Query: 1151 GDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRP 1210
GDAG + H S++ ++S + V L Q A G L V L C P
Sbjct: 866 GDAGSPAPPFH---------SSSYRISLAGVEPSLVQA---ALGQL-VRLSCSDDTAPES 912
Query: 1211 TISWARNGEEVQFSDRILLQPDDSLQILAPVEA-DVGFYTCNATNALGYDSVSIAVTLAG 1269
+W ++G+ + SDR LQ D SL I+ P++A D G Y+C +T G DS I + + G
Sbjct: 913 QAAWQKDGQPIS-SDRHRLQFDGSL-IIHPLQAEDAGTYSCGSTRP-GRDSQKIQLRIIG 969
Query: 1270 KPLVKTSRMTVINTEKPA-VTVDIGS-----------------------------TIKTV 1299
+ S + +P D G +
Sbjct: 970 GDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDAS 1029
Query: 1300 QGVNVTINCQVAGVPEAEVTWFRNKSKLGSPHH--LHEGSLLLTNVSSSDQGLYSCRAAN 1357
G + + C+ G P + W R+ + SP H +GSL+++ V+ D G Y+C A N
Sbjct: 1030 PGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAFN 1089
Query: 1358 LHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLG 1417
QL R L T LP +T P G++A L
Sbjct: 1090 GQDRDQRWVQL---------------RVLGELTISGLPPTVTVP--------EGDTARLL 1126
Query: 1418 CPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSCLA 1471
C + G V NI W G P V A G H G +L + NL +G ++C A
Sbjct: 1127 CVVAGESV-NIRWSRNGLP-VQADGHRVHQSPDGTLL-IYNLRARDEGSYTCSA 1177
Score = 51.6 bits (122), Expect = 7e-06
Identities = 51/207 (24%), Positives = 83/207 (40%), Gaps = 34/207 (16%)
Query: 1294 STIKTVQGVNVTINCQVAGVPEAEVTWFRNKSKLGSPHHL--HEGSLLLTNVSSSDQGLY 1351
S ++ G V ++C PE++ W ++ + S H +GSL++ + + D G Y
Sbjct: 890 SLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAEDAGTY 949
Query: 1352 SCRAANLHGELTESTQLLILDP-------------PQVPTQLEDIRALLAATGP--NLPS 1396
SC + G ++ QL I+ PQ +D A GP +PS
Sbjct: 950 SCGSTR-PGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDF-GQAGAAGPLGAIPS 1007
Query: 1397 VLTSPLGTQLVLD----------PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHH 1446
P +L LD PG + C +G P P I W GQP+ + H
Sbjct: 1008 SHPQP-ANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSS----PRH 1062
Query: 1447 ILAAGQILQVANLSGGSQGEFSCLAQN 1473
L L ++ ++ G ++C+A N
Sbjct: 1063 QLQPDGSLVISRVAVEDGGFYTCVAFN 1089
Score = 40.8 bits (94), Expect = 0.012
Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 12/136 (8%)
Query: 895 VVLRCPARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTC-SAGPAR 953
V L C + W+KDGQ + S H + G L IH L+ DAG Y+C S P R
Sbjct: 900 VRLSCSDDTAPESQAAWQKDGQPISSDRH-RLQFDGSLIIHPLQAEDAGTYSCGSTRPGR 958
Query: 954 --EHFVIKLIGGNRKL-----VARPLSPRSEEEVLAGRKG--GPKEALQTHKHQNGIFSN 1004
+ +++IGG+ + ++R PR + G+ G GP A+ + Q
Sbjct: 959 DSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDF-GQAGAAGPLGAIPSSHPQPANRLR 1017
Query: 1005 GSKAEKRGLAANPGSR 1020
+ + R + A+PG R
Sbjct: 1018 LDQNQPRVVDASPGQR 1033
Score = 40.8 bits (94), Expect = 0.012
Identities = 22/59 (37%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 891 PKTAVVLRCPARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSA 949
P + + C A P I W++DGQ + S H + P G L I R+ D G YTC A
Sbjct: 1030 PGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPRH-QLQPDGSLVISRVAVEDGGFYTCVA 1087
Score = 33.9 bits (76), Expect = 1.4
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTPV 1584
+ WS C+R+CGGGV R C + G S+ V
Sbjct: 33 SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCV 65
Score = 32.0 bits (71), Expect = 5.5
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query: 909 ITWEKDGQHLISSTH-VTVAPFGYLKIHRLKPSDAGVYTCSA 949
I W ++G + + H V +P G L I+ L+ D G YTCSA
Sbjct: 1136 IRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSA 1177
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 257 bits (657), Expect = 6e-68
Identities = 213/763 (27%), Positives = 300/763 (39%), Gaps = 133/763 (17%)
Query: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
Query: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
G++ + + + P + E L GP T I + N G +F
Sbjct: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
Query: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
YQ +I + + N PE ++ +P L
Sbjct: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
Query: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
Query: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
Query: 462 LCIDHRGMHTGGCSPKTKPHIKEECIVPTPC-YKPKEKLPVEAKLPWFKQAQELEEGAAV 520
C G GG S + P C + P+ + +L + E G+
Sbjct: 749 QCRQEFG--GGGSS-----------VPPERCGHLPRPNITQSCQL---RLCGHWEVGS-- 790
Query: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG--PKPASQRAC 578
WS C+V CG G + R VRC + ++ EC P+P S+ AC
Sbjct: 791 ---------PWSQCSVRCGRGQRSRQVRC-----VGNNGDEVSEQECASGPPQPPSREAC 836
Query: 579 YAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK- 637
GPC T F DW +KCS CG G+Q V CL
Sbjct: 837 DMGPC-----------TTAWFHS--------DWS----SKCSAECGTGIQRRSVVCLGSG 873
Query: 638 QTREPAEENL-------CVTSRRPPQLLKSCNLDPCPA--RWEIGKWSPCSLTCGVGLQT 688
P + C T RPP +++C+L PC RW G W CS CG G Q
Sbjct: 874 AALGPGQGEAGAGTGQSCPTGSRPPD-MRACSLGPCERTWRWYTGPWGECSSECGSGTQR 932
Query: 689 RDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGV 748
RD+ C L E N V P+P +Q C C W+ W PCSR+C GG
Sbjct: 933 RDIICVSKLGTEFN--VTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGT 990
Query: 749 QKREVLCKQRMADGSFLELPETFCSASKPACQQACKK---DDC 788
Q REV C S P+ S +P Q C + D C
Sbjct: 991 QTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQC 1033
Score = 154 bits (389), Expect = 7e-37
Identities = 118/460 (25%), Positives = 177/460 (38%), Gaps = 85/460 (18%)
Query: 424 PKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGGCSPKTKP 480
P+ P+ P W S C+ +CG+G+ + LCI + C+ +P
Sbjct: 657 PRTPLGSPAAY-----WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP 711
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
E TPC P + +A E W++C+ +CG
Sbjct: 712 PASPEPCHGTPC-------------PPYWEAGE-----------------WTSCSRSCGP 741
Query: 541 GTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPASQRACYAGPCSGEIPEFNPDETDGLF 599
GTQ R ++C+ F + +P + C P+P ++C C
Sbjct: 742 GTQHRQLQCRQ--EFGGGGSSVPPERCGHLPRPNITQSCQLRLCG--------------- 784
Query: 600 GGLQDFDELYDWEYEG-FTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLL 658
WE +++CS CG G + V C+ E +E+ C + P
Sbjct: 785 ----------HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE-CASGPPQPPSR 833
Query: 659 KSCNLDPCPARWEIGKWSP-CSLTCGVGLQTRDVFC---SHLLSREMNETVILADELCRQ 714
++C++ PC W WS CS CG G+Q R V C L E + C
Sbjct: 834 EACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPT 893
Query: 715 -PKPSTVQACNRFNCPPAW--YPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETF 771
+P ++AC+ C W Y W CS CG G Q+R+++C ++ + P
Sbjct: 894 GSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNC 953
Query: 772 CSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTL 831
+P Q C+ C W + W+ CS SC GTQTR C +T ST
Sbjct: 954 SHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQT------LSTR 1007
Query: 832 CPPLPFSSSIRPCMLATCA-RPG---RPSTKHSPHIAAAR 867
CPP S RPC C+ RP + S+ H P + AR
Sbjct: 1008 CPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQAR 1047
Score = 134 bits (336), Expect = 1e-30
Identities = 89/299 (29%), Positives = 138/299 (46%), Gaps = 27/299 (9%)
Query: 1478 LMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNS-TEVNPAHCAGKVRPAVQ 1536
+ Q L + +W + CS CG RG + ++RC+ N+ EV+ CA
Sbjct: 774 ITQSCQLRLCGHWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
Query: 1537 PIACNRRDCPSRWMVTSWSA-CTRSCGGGVQTRRVTCQKLKAS-----GISTPVSNDMCT 1590
AC+ C + W + WS+ C+ CG G+Q R V C A+ G + + C
Sbjct: 833 REACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
Query: 1591 QVAKRPVDTQACNQQLCVE---WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDG----IT 1643
RP D +AC+ C W WG+C+ C Q R + C ++ G +T
Sbjct: 893 -TGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGS---GTQRRDIICVSKLGTEFNVT 948
Query: 1644 LPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAV 1703
PS CS LPRP + Q C +AC W + W+ C+ +C G Q+R V+C+ TN+ +
Sbjct: 949 SPSN-CSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQG-GTQTREVQCL--STNQTL 1004
Query: 1704 PEHLCSWGPRPANWQRCNITPCENM---ECRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
C RP+ + CN PC +C+D++ +C V Q +LC + + CC +C
Sbjct: 1005 STR-CPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 125 bits (313), Expect = 5e-28
Identities = 83/251 (33%), Positives = 120/251 (47%), Gaps = 21/251 (8%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNST--EVNPAHCAGKVRPAVQPIACNRRDCP 1546
YW V A CSASCG +GV +P C+ + E++ CA RP P C+ CP
Sbjct: 667 YWKRVGHSA-CSASCG-KGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP 724
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
W W++C+RSCG G Q R++ C++ + G + V + C + RP TQ+C +L
Sbjct: 725 PYWEAGEWTSCSRSCGPGTQHRQLQCRQ-EFGGGGSSVPPERCGHL-PRPNITQSCQLRL 782
Query: 1607 CVEWAFSS-WGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQC-SALPRPVSTQNCWSE 1664
C W S W QC+ C + RQV C +G + ++C S P+P S + C
Sbjct: 783 CGHWEVGSPWSQCSVRC---GRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
Query: 1665 ACSVHWRVSLW-TLCTATCGNYGFQSRRVECVHART--------NKAVPEHLCSWGPRPA 1715
C+ W S W + C+A CG G Q R V C+ + A C G RP
Sbjct: 840 PCTTAWFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPP 898
Query: 1716 NWQRCNITPCE 1726
+ + C++ PCE
Sbjct: 899 DMRACSLGPCE 909
Score = 50.8 bits (120), Expect = 1e-05
Identities = 34/111 (30%), Positives = 48/111 (43%), Gaps = 6/111 (5%)
Query: 1632 RQVF-CQTRD-GITLPSEQCSALPRP-VSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQ 1688
R +F C +R+ G L C+A RP S + C C +W WT C+ +CG G Q
Sbjct: 686 RPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGP-GTQ 744
Query: 1689 SRRVECVH--ARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYC 1737
R+++C +VP C PRP Q C + C + E C
Sbjct: 745 HRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQC 795
Score = 42.7 bits (99), Expect = 0.003
Identities = 75/342 (21%), Positives = 123/342 (35%), Gaps = 61/342 (17%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
Query: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV--------ELAPKVLDGTRCYTE 147
H +V P + CS++C + V E++ +
Sbjct: 785 HWEV-------------GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
Query: 148 SLDMCISGLCQIV--------GCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
S + C G C C + G+ ++ + VC G G+ L GQ ++
Sbjct: 832 SREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSV-VCLGSGAA--LGPGQGEAGAGTG 888
Query: 200 KSDDTVVAIPYGSR--HIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQ 257
+S P GSR +R GP T G GE S S G+ +
Sbjct: 889 QS------CPTGSRPPDMRACSLGPCERTWRWYT--GPWGECS-SECGSGTQRRDIICVS 939
Query: 258 KFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGY 317
K + + P + + +Q Q RW T + PCS +C GG
Sbjct: 940 KLGTE--FNVTSPSNCSHLPR-------PPALQPCQGQACQDRWFSTPWSPCSRSCQGGT 990
Query: 318 QLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Q +C L +N+ ++ + P ++P K + CN PC
Sbjct: 991 QTREVQC--LSTNQTLSTR----CPPQLRPSRK-RPCNSQPC 1025
Score = 33.9 bits (76), Expect = 1.4
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
+G+W W W+ CS+ CG G R C
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 33.1 bits (74), Expect = 2.5
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
G W+ PWS+CS CG G RC+ + E
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
Score = 31.6 bits (70), Expect = 7.1
Identities = 13/26 (50%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 732 WYP-AQWQPCSRTCGGGVQKREVLCK 756
W P QW CS+ CG GVQ+R C+
Sbjct: 47 WGPWVQWASCSQPCGVGVQRRSRTCQ 72
Score = 31.2 bits (69), Expect = 9.3
Identities = 11/20 (55%), Positives = 15/20 (75%)
Query: 1554 WSACTRSCGGGVQTRRVTCQ 1573
W++C++ CG GVQ R TCQ
Sbjct: 53 WASCSQPCGVGVQRRSRTCQ 72
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 248 bits (632), Expect = 5e-65
Identities = 221/825 (26%), Positives = 334/825 (40%), Gaps = 149/825 (18%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413
Query: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 472
Query: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRG--- 190
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G
Sbjct: 473 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 532
Query: 191 -----QYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTG 245
+Y + L+ T + +V Y + H L HL + G+ S+S
Sbjct: 533 AGRAREYVTFLTVTPNLTSV----YIANHRPLF----THLAVRIGGRYVVAGKMSISPNT 584
Query: 246 TF--LVDNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQF 291
T+ L+++ V+++ + P E +R+ GPL D +++ R G + F
Sbjct: 585 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITF 644
Query: 292 IFYQPIIHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
++QP + W PCS +CG G + + C D +V C + +P
Sbjct: 645 TYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPP 700
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI 408
+ C L+PCP P W + CS+SCGGG++ R V CVE
Sbjct: 701 AWPEACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--A 741
Query: 409 QGH-VTSVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
QG + ++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 742 QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV 801
Query: 465 DHRGMHTGGCSPKTK--PHIKEECIVPTPC----------YKPKEKLPVEAKLPWFKQAQ 512
G +P T+ + E+ P PC + +A PW
Sbjct: 802 PGA---DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW----G 854
Query: 513 ELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDE--CE-G 569
+ GA + + P A S C+V+CG G C S +P+ E C
Sbjct: 855 SIRTGAQAAH--VWTPAAGS-CSVSCGRGLMELRFLCM------DSALRVPVQEELCGLA 905
Query: 570 PKPASQR-ACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQ 628
KP S+R C A PC W+Y+ CS SCG GV
Sbjct: 906 SKPGSRREVCQAVPCPAR------------------------WQYK-LAACSVSCGRGVV 940
Query: 629 EAVVSCLNKQTREPAEENLCVTSRR---PPQLLKSCNLDPCPARWEIGKWSPCSLTCGVG 685
++ C + EE L T + P+ ++C+L+PCP RW++ PCS +CG+G
Sbjct: 941 RRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLG 1000
Query: 686 LQTRDVFCSHLLSREMNETVILADELCRQ-PKPSTVQACNRFNCPPAWYPAQWQPCSRTC 744
R V C L + + V + + C +P C +C W+ W CS +C
Sbjct: 1001 TARRSVACVQL---DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSC 1057
Query: 745 GGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDC 788
G G+Q+R C A +P FC KP + C C
Sbjct: 1058 GDGIQRRRDTCLGPQAQA---PVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 184 bits (467), Expect = 7e-46
Identities = 142/514 (27%), Positives = 204/514 (39%), Gaps = 73/514 (14%)
Query: 371 YDLYHPLPRWEATPWTA----CSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM 426
+ + P PR +A W A CS SCG G++ SC+++ + V +V+ P
Sbjct: 644 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW 702
Query: 427 PIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKT------K 479
P A C + CP W ++ PC+ +CG GLR R V C++ +G P +
Sbjct: 703 PEA--CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQ 760
Query: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
P + E P PC E VSE S+CT G
Sbjct: 761 PAVALETCNPQPCPARWE----------------------VSEP--------SSCTSAGG 790
Query: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSG-------------E 586
G + C L EGP ++ PC G
Sbjct: 791 AGLALENETCV------PGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 844
Query: 587 IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN 646
E P + G Q + W CS SCG G+ E C++ R P +E
Sbjct: 845 AGEKAPSPWGSIRTGAQ---AAHVWT-PAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE 900
Query: 647 LCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVI 706
LC + +P + C PCPARW+ K + CS++CG G+ R ++C+ + E ++
Sbjct: 901 LCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEIL 959
Query: 707 LADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
L + P+P +AC+ CPP W PCS +CG G +R V C Q + G +E
Sbjct: 960 LDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVE 1018
Query: 767 LPETFCSA-SKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLST 825
+ E C+A +P C DC W + W ECS SCG+G Q R C L
Sbjct: 1019 VDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQA 1075
Query: 826 VVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKH 859
V + C LP ++R C C G +H
Sbjct: 1076 PVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQH 1109
Score = 107 bits (267), Expect = 1e-22
Identities = 69/234 (29%), Positives = 100/234 (42%), Gaps = 12/234 (5%)
Query: 1498 TCSASCGNRGVQQPRLRCLLNSTEVNPAH--CAGKVRPAVQPIACNRRDCPSRWMVTSWS 1555
+CS SCG RG+ + R C+ ++ V C +P + C CP+RW +
Sbjct: 872 SCSVSCG-RGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 929
Query: 1556 ACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV-EWAFSS 1614
AC+ SCG GV R + C + + D Q RP +AC+ + C W S
Sbjct: 930 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 989
Query: 1615 WGQCNGPCIGPHLAVQHRQVFCQTRD---GITLPSEQCSALPRPVSTQNCWSEACSVHWR 1671
G C+ C L R V C D + + C+AL RP ++ C C+ W
Sbjct: 990 LGPCSASC---GLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1046
Query: 1672 VSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
V W C+ +CG+ G Q RR C+ + VP C P+P + C PC
Sbjct: 1047 VGTWMECSVSCGD-GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 82.0 bits (201), Expect = 5e-15
Identities = 54/179 (30%), Positives = 75/179 (41%), Gaps = 13/179 (7%)
Query: 1495 RLATCSASCGNRGVQQPRLRCLLNSTEVN------PAHCAGKVRPAVQPIACNRRDCPSR 1548
+LA CS SCG RGV + L C E + C G RP Q AC+ CP R
Sbjct: 927 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQE-ACSLEPCPPR 984
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W V S C+ SCG G R V C +L G V C + +
Sbjct: 985 WKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEASVPCLIADCTY 1043
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFC-QTRDGITLPSEQCSALPRPVSTQNCWSEAC 1666
W +W +C+ C +Q R+ C + +P++ C LP+PV+ + CW+ C
Sbjct: 1044 RWHVGTWMECSVSCGD---GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 77.4 bits (189), Expect = 1e-13
Identities = 70/274 (25%), Positives = 105/274 (38%), Gaps = 41/274 (14%)
Query: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRD 1544
Q + W+ R CS SCG G++ CL + + V C G +P P AC
Sbjct: 653 QAWVWAAVR-GPCSVSCG-AGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP 710
Query: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP-VDTQACN 1603
CP W V + C+ SCGGG++ R V C + + S + T + C A++P V + CN
Sbjct: 711 CPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKT-LPPARCRAGAQQPAVALETCN 769
Query: 1604 QQLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLP-------SEQCSALPRP 1655
Q C W S C G LA+++ + DG+ P ++ P P
Sbjct: 770 PQPCPARWEVSEPSSCTS-AGGAGLALEN-ETCVPGADGLEAPVTEGPGSVDEKLPAPEP 827
Query: 1656 VSTQNC-------------------WSEACSVHWRVSLWT----LCTATCGNYGFQSRRV 1692
+C W + +WT C+ +CG G R
Sbjct: 828 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGR-GLMELRF 886
Query: 1693 ECVHARTNKAVPEHLCSWGPRPANWQR-CNITPC 1725
C+ + V E LC +P + + C PC
Sbjct: 887 LCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 920
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/138 (36%), Positives = 63/138 (45%), Gaps = 25/138 (18%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLL----NSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
W V L CSASCG G + + C+ EV+ A CA VRP + C DC
Sbjct: 985 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEAS-VPCLIADCT 1042
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
RW V +W C+ SCG G+Q RR TC +A PV D C + K PV + C
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQA---QAPVPADFCQHLPK-PVTVRGC---- 1094
Query: 1607 CVEWAFSSWGQCNGPCIG 1624
WA GPC+G
Sbjct: 1095 ---WA--------GPCVG 1101
Score = 37.0 bits (84), Expect = 0.17
Identities = 36/97 (37%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 1516 LLNSTE--VNPAHCAGKVRPAVQ--PIACNRRDCPSRWMVTSW---SACTRSCGGGVQTR 1568
LL+ TE V G+ R V+ PIA RW +SW S C+RSCGGGV TR
Sbjct: 323 LLDGTECGVEKWCSKGRCRSLVELTPIAAVH----GRW--SSWGPRSPCSRSCGGGVVTR 376
Query: 1569 RVTCQKLK-ASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
R C + A G V D+ ++ +TQAC +
Sbjct: 377 RRQCNNPRPAFGGRACVGADLQAEMC----NTQACEK 409
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 248 bits (632), Expect = 5e-65
Identities = 221/825 (26%), Positives = 334/825 (40%), Gaps = 149/825 (18%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 503
Query: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRG--- 190
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G
Sbjct: 504 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 563
Query: 191 -----QYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTG 245
+Y + L+ T + +V Y + H L HL + G+ S+S
Sbjct: 564 AGRAREYVTFLTVTPNLTSV----YIANHRPLF----THLAVRIGGRYVVAGKMSISPNT 615
Query: 246 TF--LVDNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQF 291
T+ L+++ V+++ + P E +R+ GPL D +++ R G + F
Sbjct: 616 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITF 675
Query: 292 IFYQPIIHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
++QP + W PCS +CG G + + C D +V C + +P
Sbjct: 676 TYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPP 731
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI 408
+ C L+PCP P W + CS+SCGGG++ R V CVE
Sbjct: 732 AWPEACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--A 772
Query: 409 QGH-VTSVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
QG + ++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 773 QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV 832
Query: 465 DHRGMHTGGCSPKTK--PHIKEECIVPTPC----------YKPKEKLPVEAKLPWFKQAQ 512
G +P T+ + E+ P PC + +A PW
Sbjct: 833 PGA---DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW----G 885
Query: 513 ELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDE--CE-G 569
+ GA + + P A S C+V+CG G C S +P+ E C
Sbjct: 886 SIRTGAQAAH--VWTPAAGS-CSVSCGRGLMELRFLCM------DSALRVPVQEELCGLA 936
Query: 570 PKPASQR-ACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQ 628
KP S+R C A PC W+Y+ CS SCG GV
Sbjct: 937 SKPGSRREVCQAVPCPAR------------------------WQYK-LAACSVSCGRGVV 971
Query: 629 EAVVSCLNKQTREPAEENLCVTSRR---PPQLLKSCNLDPCPARWEIGKWSPCSLTCGVG 685
++ C + EE L T + P+ ++C+L+PCP RW++ PCS +CG+G
Sbjct: 972 RRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLG 1031
Query: 686 LQTRDVFCSHLLSREMNETVILADELCRQ-PKPSTVQACNRFNCPPAWYPAQWQPCSRTC 744
R V C L + + V + + C +P C +C W+ W CS +C
Sbjct: 1032 TARRSVACVQL---DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSC 1088
Query: 745 GGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDC 788
G G+Q+R C A +P FC KP + C C
Sbjct: 1089 GDGIQRRRDTCLGPQAQA---PVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 184 bits (467), Expect = 7e-46
Identities = 142/514 (27%), Positives = 204/514 (39%), Gaps = 73/514 (14%)
Query: 371 YDLYHPLPRWEATPWTA----CSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM 426
+ + P PR +A W A CS SCG G++ SC+++ + V +V+ P
Sbjct: 675 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW 733
Query: 427 PIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKT------K 479
P A C + CP W ++ PC+ +CG GLR R V C++ +G P +
Sbjct: 734 PEA--CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQ 791
Query: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
P + E P PC E VSE S+CT G
Sbjct: 792 PAVALETCNPQPCPARWE----------------------VSEP--------SSCTSAGG 821
Query: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSG-------------E 586
G + C L EGP ++ PC G
Sbjct: 822 AGLALENETCV------PGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 875
Query: 587 IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN 646
E P + G Q + W CS SCG G+ E C++ R P +E
Sbjct: 876 AGEKAPSPWGSIRTGAQ---AAHVWT-PAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE 931
Query: 647 LCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVI 706
LC + +P + C PCPARW+ K + CS++CG G+ R ++C+ + E ++
Sbjct: 932 LCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEIL 990
Query: 707 LADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
L + P+P +AC+ CPP W PCS +CG G +R V C Q + G +E
Sbjct: 991 LDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVE 1049
Query: 767 LPETFCSA-SKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLST 825
+ E C+A +P C DC W + W ECS SCG+G Q R C L
Sbjct: 1050 VDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQA 1106
Query: 826 VVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKH 859
V + C LP ++R C C G +H
Sbjct: 1107 PVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQH 1140
Score = 107 bits (267), Expect = 1e-22
Identities = 69/234 (29%), Positives = 100/234 (42%), Gaps = 12/234 (5%)
Query: 1498 TCSASCGNRGVQQPRLRCLLNSTEVNPAH--CAGKVRPAVQPIACNRRDCPSRWMVTSWS 1555
+CS SCG RG+ + R C+ ++ V C +P + C CP+RW +
Sbjct: 903 SCSVSCG-RGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 960
Query: 1556 ACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV-EWAFSS 1614
AC+ SCG GV R + C + + D Q RP +AC+ + C W S
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 1020
Query: 1615 WGQCNGPCIGPHLAVQHRQVFCQTRD---GITLPSEQCSALPRPVSTQNCWSEACSVHWR 1671
G C+ C L R V C D + + C+AL RP ++ C C+ W
Sbjct: 1021 LGPCSASC---GLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1077
Query: 1672 VSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
V W C+ +CG+ G Q RR C+ + VP C P+P + C PC
Sbjct: 1078 VGTWMECSVSCGD-GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 82.0 bits (201), Expect = 5e-15
Identities = 54/179 (30%), Positives = 75/179 (41%), Gaps = 13/179 (7%)
Query: 1495 RLATCSASCGNRGVQQPRLRCLLNSTEVN------PAHCAGKVRPAVQPIACNRRDCPSR 1548
+LA CS SCG RGV + L C E + C G RP Q AC+ CP R
Sbjct: 958 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQE-ACSLEPCPPR 1015
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W V S C+ SCG G R V C +L G V C + +
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEASVPCLIADCTY 1074
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFC-QTRDGITLPSEQCSALPRPVSTQNCWSEAC 1666
W +W +C+ C +Q R+ C + +P++ C LP+PV+ + CW+ C
Sbjct: 1075 RWHVGTWMECSVSCGD---GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 77.4 bits (189), Expect = 1e-13
Identities = 70/274 (25%), Positives = 105/274 (38%), Gaps = 41/274 (14%)
Query: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRD 1544
Q + W+ R CS SCG G++ CL + + V C G +P P AC
Sbjct: 684 QAWVWAAVR-GPCSVSCG-AGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP 741
Query: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP-VDTQACN 1603
CP W V + C+ SCGGG++ R V C + + S + T + C A++P V + CN
Sbjct: 742 CPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKT-LPPARCRAGAQQPAVALETCN 800
Query: 1604 QQLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLP-------SEQCSALPRP 1655
Q C W S C G LA+++ + DG+ P ++ P P
Sbjct: 801 PQPCPARWEVSEPSSCTS-AGGAGLALEN-ETCVPGADGLEAPVTEGPGSVDEKLPAPEP 858
Query: 1656 VSTQNC-------------------WSEACSVHWRVSLWT----LCTATCGNYGFQSRRV 1692
+C W + +WT C+ +CG G R
Sbjct: 859 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGR-GLMELRF 917
Query: 1693 ECVHARTNKAVPEHLCSWGPRPANWQR-CNITPC 1725
C+ + V E LC +P + + C PC
Sbjct: 918 LCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/138 (36%), Positives = 63/138 (45%), Gaps = 25/138 (18%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLL----NSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
W V L CSASCG G + + C+ EV+ A CA VRP + C DC
Sbjct: 1016 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEAS-VPCLIADCT 1073
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
RW V +W C+ SCG G+Q RR TC +A PV D C + K PV + C
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQA---QAPVPADFCQHLPK-PVTVRGC---- 1125
Query: 1607 CVEWAFSSWGQCNGPCIG 1624
WA GPC+G
Sbjct: 1126 ---WA--------GPCVG 1132
Score = 37.0 bits (84), Expect = 0.17
Identities = 36/97 (37%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 1516 LLNSTE--VNPAHCAGKVRPAVQ--PIACNRRDCPSRWMVTSW---SACTRSCGGGVQTR 1568
LL+ TE V G+ R V+ PIA RW +SW S C+RSCGGGV TR
Sbjct: 354 LLDGTECGVEKWCSKGRCRSLVELTPIAAVH----GRW--SSWGPRSPCSRSCGGGVVTR 407
Query: 1569 RVTCQKLK-ASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
R C + A G V D+ ++ +TQAC +
Sbjct: 408 RRQCNNPRPAFGGRACVGADLQAEMC----NTQACEK 440
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 248 bits (632), Expect = 5e-65
Identities = 221/825 (26%), Positives = 334/825 (40%), Gaps = 149/825 (18%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 444
Query: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 445 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 503
Query: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRG--- 190
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G
Sbjct: 504 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 563
Query: 191 -----QYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTG 245
+Y + L+ T + +V Y + H L HL + G+ S+S
Sbjct: 564 AGRAREYVTFLTVTPNLTSV----YIANHRPLF----THLAVRIGGRYVVAGKMSISPNT 615
Query: 246 TF--LVDNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQF 291
T+ L+++ V+++ + P E +R+ GPL D +++ R G + F
Sbjct: 616 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITF 675
Query: 292 IFYQPIIHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
++QP + W PCS +CG G + + C D +V C + +P
Sbjct: 676 TYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPP 731
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI 408
+ C L+PCP P W + CS+SCGGG++ R V CVE
Sbjct: 732 AWPEACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--A 772
Query: 409 QGH-VTSVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
QG + ++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 773 QGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV 832
Query: 465 DHRGMHTGGCSPKTK--PHIKEECIVPTPC----------YKPKEKLPVEAKLPWFKQAQ 512
G +P T+ + E+ P PC + +A PW
Sbjct: 833 PGA---DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW----G 885
Query: 513 ELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDE--CE-G 569
+ GA + + P A S C+V+CG G C S +P+ E C
Sbjct: 886 SIRTGAQAAH--VWTPAAGS-CSVSCGRGLMELRFLCM------DSALRVPVQEELCGLA 936
Query: 570 PKPASQR-ACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQ 628
KP S+R C A PC W+Y+ CS SCG GV
Sbjct: 937 SKPGSRREVCQAVPCPAR------------------------WQYK-LAACSVSCGRGVV 971
Query: 629 EAVVSCLNKQTREPAEENLCVTSRR---PPQLLKSCNLDPCPARWEIGKWSPCSLTCGVG 685
++ C + EE L T + P+ ++C+L+PCP RW++ PCS +CG+G
Sbjct: 972 RRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLG 1031
Query: 686 LQTRDVFCSHLLSREMNETVILADELCRQ-PKPSTVQACNRFNCPPAWYPAQWQPCSRTC 744
R V C L + + V + + C +P C +C W+ W CS +C
Sbjct: 1032 TARRSVACVQL---DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSC 1088
Query: 745 GGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDC 788
G G+Q+R C A +P FC KP + C C
Sbjct: 1089 GDGIQRRRDTCLGPQAQA---PVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 187 bits (476), Expect = 6e-47
Identities = 147/521 (28%), Positives = 208/521 (39%), Gaps = 75/521 (14%)
Query: 371 YDLYHPLPRWEATPWTA----CSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM 426
+ + P PR +A W A CS SCG G++ SC+++ + V +V+ P
Sbjct: 675 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW 733
Query: 427 PIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKT------K 479
P A C + CP W ++ PC+ +CG GLR R V C++ +G P +
Sbjct: 734 PEA--CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQ 791
Query: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
P + E P PC E VSE S+CT G
Sbjct: 792 PAVALETCNPQPCPARWE----------------------VSEP--------SSCTSAGG 821
Query: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSG-------------E 586
G + C L EGP ++ PC G
Sbjct: 822 AGLALENETCV------PGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 875
Query: 587 IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN 646
E P + G Q + W CS SCG G+ E C++ R P +E
Sbjct: 876 AGEKAPSPWGSIRTGAQ---AAHVWT-PAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE 931
Query: 647 LCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVI 706
LC + +P + C PCPARW+ K + CS++CG G+ R ++C+ + E ++
Sbjct: 932 LCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEIL 990
Query: 707 LADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
L + P+P +AC+ CPP W PCS +CG G +R V C Q + G +E
Sbjct: 991 LDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVE 1049
Query: 767 LPETFCSA-SKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLST 825
+ E C+A +P C DC W + W ECS SCG+G Q R C L
Sbjct: 1050 VDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQA 1106
Query: 826 VVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAA 866
V + C LP ++R C C G PS PH AA
Sbjct: 1107 PVPADFCQHLPKPVTVRGCWAGPCVGQGTPSL--VPHEEAA 1145
Score = 107 bits (267), Expect = 1e-22
Identities = 69/234 (29%), Positives = 100/234 (42%), Gaps = 12/234 (5%)
Query: 1498 TCSASCGNRGVQQPRLRCLLNSTEVNPAH--CAGKVRPAVQPIACNRRDCPSRWMVTSWS 1555
+CS SCG RG+ + R C+ ++ V C +P + C CP+RW +
Sbjct: 903 SCSVSCG-RGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 960
Query: 1556 ACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV-EWAFSS 1614
AC+ SCG GV R + C + + D Q RP +AC+ + C W S
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 1020
Query: 1615 WGQCNGPCIGPHLAVQHRQVFCQTRD---GITLPSEQCSALPRPVSTQNCWSEACSVHWR 1671
G C+ C L R V C D + + C+AL RP ++ C C+ W
Sbjct: 1021 LGPCSASC---GLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1077
Query: 1672 VSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
V W C+ +CG+ G Q RR C+ + VP C P+P + C PC
Sbjct: 1078 VGTWMECSVSCGD-GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 82.0 bits (201), Expect = 5e-15
Identities = 54/179 (30%), Positives = 75/179 (41%), Gaps = 13/179 (7%)
Query: 1495 RLATCSASCGNRGVQQPRLRCLLNSTEVN------PAHCAGKVRPAVQPIACNRRDCPSR 1548
+LA CS SCG RGV + L C E + C G RP Q AC+ CP R
Sbjct: 958 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQE-ACSLEPCPPR 1015
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W V S C+ SCG G R V C +L G V C + +
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEASVPCLIADCTY 1074
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFC-QTRDGITLPSEQCSALPRPVSTQNCWSEAC 1666
W +W +C+ C +Q R+ C + +P++ C LP+PV+ + CW+ C
Sbjct: 1075 RWHVGTWMECSVSCGD---GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 77.4 bits (189), Expect = 1e-13
Identities = 70/274 (25%), Positives = 105/274 (38%), Gaps = 41/274 (14%)
Query: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRD 1544
Q + W+ R CS SCG G++ CL + + V C G +P P AC
Sbjct: 684 QAWVWAAVR-GPCSVSCG-AGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP 741
Query: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP-VDTQACN 1603
CP W V + C+ SCGGG++ R V C + + S + T + C A++P V + CN
Sbjct: 742 CPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKT-LPPARCRAGAQQPAVALETCN 800
Query: 1604 QQLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLP-------SEQCSALPRP 1655
Q C W S C G LA+++ + DG+ P ++ P P
Sbjct: 801 PQPCPARWEVSEPSSCTS-AGGAGLALEN-ETCVPGADGLEAPVTEGPGSVDEKLPAPEP 858
Query: 1656 VSTQNC-------------------WSEACSVHWRVSLWT----LCTATCGNYGFQSRRV 1692
+C W + +WT C+ +CG G R
Sbjct: 859 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGR-GLMELRF 917
Query: 1693 ECVHARTNKAVPEHLCSWGPRPANWQR-CNITPC 1725
C+ + V E LC +P + + C PC
Sbjct: 918 LCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/138 (36%), Positives = 63/138 (45%), Gaps = 25/138 (18%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLL----NSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
W V L CSASCG G + + C+ EV+ A CA VRP + C DC
Sbjct: 1016 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEAS-VPCLIADCT 1073
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
RW V +W C+ SCG G+Q RR TC +A PV D C + K PV + C
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQA---QAPVPADFCQHLPK-PVTVRGC---- 1125
Query: 1607 CVEWAFSSWGQCNGPCIG 1624
WA GPC+G
Sbjct: 1126 ---WA--------GPCVG 1132
Score = 37.0 bits (84), Expect = 0.17
Identities = 36/97 (37%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 1516 LLNSTE--VNPAHCAGKVRPAVQ--PIACNRRDCPSRWMVTSW---SACTRSCGGGVQTR 1568
LL+ TE V G+ R V+ PIA RW +SW S C+RSCGGGV TR
Sbjct: 354 LLDGTECGVEKWCSKGRCRSLVELTPIAAVH----GRW--SSWGPRSPCSRSCGGGVVTR 407
Query: 1569 RVTCQKLK-ASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
R C + A G V D+ ++ +TQAC +
Sbjct: 408 RRQCNNPRPAFGGRACVGADLQAEMC----NTQACEK 440
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 243 bits (619), Expect = 2e-63
Identities = 174/589 (29%), Positives = 243/589 (41%), Gaps = 127/589 (21%)
Query: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPP 83
E DG W WG WS CSRTCG GA + R+C + C G ++ + C N+ CP
Sbjct: 540 EHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPK 599
Query: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
FR QQC AH+ + + V +D PC L C G + +A +VLDGT
Sbjct: 600 GLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD--KPCELYCSPLGKESPLLVADRVLDGTP 657
Query: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY--------KSQ 195
C D+C+ G CQ +GCD +GS KED CGVC+GDG TC LV+G + K
Sbjct: 658 CGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDS 717
Query: 196 LSATKSDDTVVAIP-----------YGSRHI--RLVLKGPDHLYLETKTLQGTKGENSLS 242
+ + D + +P Y R + ++ KGP L L L + +
Sbjct: 718 GKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIH 777
Query: 243 STGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWR 302
T V N + + Q P+K P + FI W
Sbjct: 778 YEYTVPV-NRTAENQSEPEK-------PQDSLFI------------------------WT 805
Query: 303 ETDFFPCSATCGGGYQLTSAECYDL--RSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
+ + CS CGGG + T C + ++ +V D C P+ +P+P+++ CNL PC
Sbjct: 806 HSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDC---PQASRPEPQVRRCNLHPCQ 862
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
+ RW A PW+ CS++C G Q R V+CV + G + C
Sbjct: 863 S-----------------RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC 905
Query: 421 MYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
P+ Q C DC W A EWS C+ +CG+G+ R V C + +G C T+
Sbjct: 906 P-GPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTR 960
Query: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
P +E C + CY+ K WS C+ TCG
Sbjct: 961 PRAEEACEDYSGCYEWK-------------------------------TGDWSTCSSTCG 989
Query: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPASQRACYAGPCSGEI 587
G Q R+V+C V EC KPA R CY C+ I
Sbjct: 990 KGLQSRVVQCM------HKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
Score = 161 bits (408), Expect = 5e-39
Identities = 90/264 (34%), Positives = 127/264 (48%), Gaps = 22/264 (8%)
Query: 606 DELYDWEYEGFTKCSESCGGGVQEAVVSCLN--KQTREPAEENLCVTSRRPPQLLKSCNL 663
D L+ W + G+ CS CGGG + +VSC +T ++ C + RP ++ CNL
Sbjct: 799 DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
Query: 664 DPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADEL-CRQPKPSTVQA 722
PC +RW G WSPCS TC G Q R+V C + L N T + L C P+P+ VQ+
Sbjct: 859 HPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQL---QNGTHVATRPLYCPGPRPAAVQS 915
Query: 723 CNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQ 781
C +C W ++W CS +CG GV KR V C C AS +P ++
Sbjct: 916 CEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK----------CDASTRPRAEE 965
Query: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
AC+ EW DW+ CS++CG+G Q+R C + T + + CP L +
Sbjct: 966 ACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKV-----TGRHGSECPALSKPAPY 1020
Query: 842 RPCMLATCARPGRPSTKHSPHIAA 865
R C C +T SP +AA
Sbjct: 1021 RQCYQEVCNDRINANTITSPRLAA 1044
Score = 128 bits (322), Expect = 4e-29
Identities = 92/312 (29%), Positives = 132/312 (42%), Gaps = 42/312 (13%)
Query: 1471 AQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTE--VNPAH 1526
A+N++ + SL I W+ CS CG G ++ + C ++N T VN +
Sbjct: 788 AENQSEPEKPQDSLFI----WTHSGWEGCSVQCGG-GERRTIVSCTRIVNKTTTLVNDSD 842
Query: 1527 CAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSN 1586
C RP Q CN C SRW+ WS C+ +C G Q R VTC +G
Sbjct: 843 CPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRP 902
Query: 1587 DMCTQVAKRPVDTQACNQQLCVE-WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLP 1645
C RP Q+C Q C+ W S W QC+ C V R V C G
Sbjct: 903 LYCP--GPRPAAVQSCEGQDCLSIWEASEWSQCSASC---GKGVWKRTVACTNSQG---- 953
Query: 1646 SEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPE 1705
+C A RP + + C + W+ W+ C++TCG G QSR V+C+H T + E
Sbjct: 954 --KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGK-GLQSRVVQCMHKVTGRHGSE 1010
Query: 1706 HLCSWGPRPANWQRCNITPCENMECRDT------------------TRYCEKVKQLKLCQ 1747
C +PA +++C C + +T T YC +++ LCQ
Sbjct: 1011 --CPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQ 1068
Query: 1748 LSQFKSRCCGTC 1759
++ RCC TC
Sbjct: 1069 DMRWYQRCCQTC 1080
Score = 94.7 bits (234), Expect = 7e-19
Identities = 69/262 (26%), Positives = 102/262 (38%), Gaps = 46/262 (17%)
Query: 531 WSACTVTCGVGTQVRIVRC-QVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE 589
W C+V CG G + IV C +++ + V D + P+P +R C PC
Sbjct: 809 WEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRR-CNLHPCQSR--- 864
Query: 590 FNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC---LNKQTREPAEEN 646
W ++ CS +C G Q V+C L T
Sbjct: 865 ---------------------WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPL 903
Query: 647 LCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVI 706
C R P ++SC C + WE +WS CS +CG G+ R V C++ + T
Sbjct: 904 YCPGPR--PAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDAST-- 959
Query: 707 LADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
+P +AC ++ W W CS TCG G+Q R V C ++ E
Sbjct: 960 ---------RPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE 1010
Query: 767 LPETFCSASKPACQQACKKDDC 788
P + SKPA + C ++ C
Sbjct: 1011 CP----ALSKPAPYRQCYQEVC 1028
Score = 92.4 bits (228), Expect = 3e-18
Identities = 84/358 (23%), Positives = 134/358 (37%), Gaps = 84/358 (23%)
Query: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM-PIAQPCNIFDCP 438
W + W CS CGGG + VSC + T V + C + P + CN+ C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRI-VNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
Query: 439 -KWLAQEWSPCTVTCGQGLRYRVVLCIDH--RGMHTGGCSPKTKPHIKEECIVPTPCYKP 495
+W+A WSPC+ TC +G ++R V C+ G H + P Y P
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTH----------------VATRPLYCP 906
Query: 496 KEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSF 555
+ P Q+ E ++ ++ E WS C+ +CG G R V C +
Sbjct: 907 GPR-------PAAVQSCEGQDCLSIWEASE-----WSQCSASCGKGVWKRTVAC----TN 950
Query: 556 SQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEG 615
SQ D +P ++ AC +D+ Y+W+
Sbjct: 951 SQGKCDA------STRPRAEEAC------------------------EDYSGCYEWKTGD 980
Query: 616 FTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKW 675
++ CS +CG G+Q VV C++K T E ++ P + C + C R
Sbjct: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAP---YRQCYQEVCNDRINANTI 1037
Query: 676 SPCSLTCGVGLQTRD---VFCSHLLSREMNETVILADELC-----------RQPKPST 719
+ L TRD V+C + + + + + C RQP P++
Sbjct: 1038 TSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQPPPNS 1095
Score = 36.6 bits (83), Expect = 0.22
Identities = 30/122 (24%), Positives = 43/122 (35%), Gaps = 7/122 (5%)
Query: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCP------PLPF 837
K D W S W CS CG G + C +++ +T+VN + CP P
Sbjct: 796 KPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNK-TTTLVNDSDCPQASRPEPQVR 854
Query: 838 SSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVL 897
++ PC A P P + R+V + Q H P+ A V
Sbjct: 855 RCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQ 914
Query: 898 RC 899
C
Sbjct: 915 SC 916
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 233 bits (594), Expect = 1e-60
Identities = 165/506 (32%), Positives = 224/506 (44%), Gaps = 77/506 (15%)
Query: 28 SEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDC 81
+++ +DG W +W + CSRTCG G + R+C + + C G N Y+ C+ +C
Sbjct: 546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
Query: 82 PPEAGDFRAQQCSAHN------DVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVEL 134
DFRAQQC N + KHH WLP + DP C L CQ+K T V +
Sbjct: 606 QKHFEDFRAQQCQQRNSHFEYQNTKHH-----WLPYEHPDPKKRCHLYCQSKETGDVAYM 660
Query: 135 APKVLDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY- 192
V DGT C Y + +C+ G C VGCD ++GS ED CGVC GD S CR V+G +
Sbjct: 661 KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT 720
Query: 193 --KSQLSATKSDDTVVAIPYGSRHIRLVL-KGPDHLYLETKTLQG---TKGENSLSSTGT 246
+L K D IP G+RH+ + + H+ G G+ + + T
Sbjct: 721 RTPRKLGYLKMFD----IPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRT 776
Query: 247 FLVDNSSVDFQKFPDKEILRMAGPLTADFIVKI---RNSGSADSTVQFIFYQ---PIIH- 299
F+ D+ D E L GPL IV I N + T ++I ++ P I+
Sbjct: 777 FIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINS 836
Query: 300 -----------RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
W + CS CGGG+Q T C N++V +C N KPK
Sbjct: 837 NNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCE---ANKKPK 893
Query: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEED 407
P + CN+ C HPL W A W C+ +CG G Q R V C++
Sbjct: 894 PIRRMCNIQECT--------------HPL--WVAEEWEHCTKTCGSSGYQLRTVRCLQPL 937
Query: 408 IQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
+ G SV CM + +PCN CP +W WS C+VTCG+G R VLC
Sbjct: 938 LDGTNRSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--R 994
Query: 467 RGMHTGGCSPKTKPHIKEECIVPTPC 492
G H G KP C +P PC
Sbjct: 995 AGDHCDG----EKPESVRACQLP-PC 1015
Score = 111 bits (278), Expect = 5e-24
Identities = 60/197 (30%), Positives = 89/197 (45%), Gaps = 15/197 (7%)
Query: 602 LQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSC 661
+Q+ + ++W + +++CS+ CGGG Q C K + + C +++P + + C
Sbjct: 840 IQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMC 899
Query: 662 NLDPCP-ARWEIGKWSPCSLTCG-VGLQTRDVFCSHLLSREMNETVILADELCRQPKPST 719
N+ C W +W C+ TCG G Q R V C L N +V + C +P +
Sbjct: 900 NIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSV--HSKYCMGDRPES 957
Query: 720 VQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPAC 779
+ CNR CP W W CS TCG G + R+VLC R D C KP
Sbjct: 958 RRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--RAGD---------HCDGEKPES 1006
Query: 780 QQACKKDDCPSEWLLSD 796
+AC+ C E L D
Sbjct: 1007 VRACQLPPCNDEPCLGD 1023
Score = 107 bits (267), Expect = 1e-22
Identities = 51/149 (34%), Positives = 74/149 (49%), Gaps = 5/149 (3%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
W + WS CS CG G Q C +M E ++PKP + CN C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFC--EANKKPKPIR-RMCNIQECT 905
Query: 730 -PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
P W +W+ C++TCG G Q R V C Q + DG+ + +C +P ++ C +
Sbjct: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVP 965
Query: 788 CPSEWLLSDWTECSTSCGEGTQTRSAICR 816
CP++W W+ECS +CGEGT+ R +CR
Sbjct: 966 CPAQWKTGPWSECSVTCGEGTEVRQVLCR 994
Score = 87.4 bits (215), Expect = 1e-16
Identities = 56/218 (25%), Positives = 90/218 (41%), Gaps = 19/218 (8%)
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W + SWS C++ CGGG Q + C++ + + V C K + CN Q C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKM---VHRSFCEANKKPKPIRRMCNIQECT 905
Query: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI--TLPSEQCSALPRPVSTQNCWSE 1664
W W C C ++ + DG ++ S+ C RP S + C
Sbjct: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRV 964
Query: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
C W+ W+ C+ TCG G + R+V C +H C G +P + + C + P
Sbjct: 965 PCPAQWKTGPWSECSVTCGE-GTEVRQVLC-------RAGDH-CD-GEKPESVRACQLPP 1014
Query: 1725 CENMEC-RDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
C + C D + +C+ + C + + CC +C K
Sbjct: 1015 CNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSK 1052
Score = 76.6 bits (187), Expect = 2e-13
Identities = 57/204 (27%), Positives = 82/204 (40%), Gaps = 44/204 (21%)
Query: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
++WS C+ CG G Q C+ S ++ V + + PKP +R C C+ +
Sbjct: 852 KSWSQCSKPCGGGFQYTKYGCR-RKSDNKMVHRSFCEANKKPKPI-RRMCNIQECTHPL- 908
Query: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCLNKQ---TREPAE 644
W E + C+++CG G Q V CL T
Sbjct: 909 ----------------------WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVH 946
Query: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
C+ R P+ + CN PCPA+W+ G WS CS+TCG G + R V C
Sbjct: 947 SKYCMGDR--PESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR---------- 994
Query: 705 VILADELCRQPKPSTVQACNRFNC 728
A + C KP +V+AC C
Sbjct: 995 ---AGDHCDGEKPESVRACQLPPC 1015
Score = 67.0 bits (162), Expect = 2e-10
Identities = 41/123 (33%), Positives = 56/123 (45%), Gaps = 10/123 (8%)
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPSEQCSA--LPRPVSTQNCWSEA 1665
EWA SW QC+ PC G Q+ + C+ + D + C A P+P+ E
Sbjct: 848 EWALKSWSQCSKPCGG---GFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
Query: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHA---RTNKAVPEHLCSWGPRPANWQRCNI 1722
W W CT TCG+ G+Q R V C+ TN++V C G RP + + CN
Sbjct: 905 THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNR 963
Query: 1723 TPC 1725
PC
Sbjct: 964 VPC 966
Score = 64.7 bits (156), Expect = 8e-10
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 36/152 (23%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCL---LNSTE--VNPAHCAGKVRPAVQPIACNRRDC 1545
W + C+ +CG+ G Q +RCL L+ T V+ +C G + +P CNR C
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP--CNRVPC 966
Query: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
P++W WS C+ +CG G + R+V C+ + D C ++P +AC
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCR-----------AGDHCD--GEKPESVRACQLP 1013
Query: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQ 1637
C + PC+G + +FCQ
Sbjct: 1014 PCND----------EPCLG------DKSIFCQ 1029
Score = 61.6 bits (148), Expect = 6e-09
Identities = 58/237 (24%), Positives = 86/237 (36%), Gaps = 72/237 (30%)
Query: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPH-IKEECIVPTP 491
D +W + WS C+ CG G +Y C D++ +H C KP I+ C +
Sbjct: 845 DTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNI--- 901
Query: 492 CYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRC- 549
QE P ++ E W CT TCG G Q+R VRC
Sbjct: 902 --------------------QECTH-------PLWVAEEWEHCTKTCGSSGYQLRTVRCL 934
Query: 550 QVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELY 609
Q LL + + C G +P S+R C PC +
Sbjct: 935 QPLLDGTN--RSVHSKYCMGDRPESRRPCNRVPCPAQ----------------------- 969
Query: 610 DWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
W+ +++CS +CG G + V C + C P+ +++C L PC
Sbjct: 970 -WKTGPWSECSVTCGEGTEVRQVLC--------RAGDHC--DGEKPESVRACQLPPC 1015
Score = 37.7 bits (86), Expect = 0.100
Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 2/63 (3%)
Query: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQR-CNI 1722
E + W + W+ C+ CG GFQ + C NK V C +P +R CNI
Sbjct: 843 ELDTFEWALKSWSQCSKPCGG-GFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNI 901
Query: 1723 TPC 1725
C
Sbjct: 902 QEC 904
Score = 34.3 bits (77), Expect = 1.1
Identities = 20/66 (30%), Positives = 28/66 (42%), Gaps = 10/66 (15%)
Query: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC----PPLPFSSSIRPCML 846
EW L W++CS CG G Q CR+ + +V+ + C P P R C +
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSD---NKMVHRSFCEANKKPKPIR---RMCNI 901
Query: 847 ATCARP 852
C P
Sbjct: 902 QECTHP 907
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 230 bits (587), Expect = 8e-60
Identities = 152/486 (31%), Positives = 223/486 (45%), Gaps = 60/486 (12%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W W WS CSR+CG G + R+C + C G R+R C+ CP
Sbjct: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
Query: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
FR QCS + + + GQ + W+PV ND NPC L C+ +L V+DGT CY
Sbjct: 598 SFRHVQCSHFDAMLYKGQLHTWVPVVNDV-NPCELHCRPANEYFAEKLRDAVVDGTPCYQ 656
Query: 147 --ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDT 204
S D+CI+G+C+ VGCD ++ S ED CGVC+G+GSTC V G ++ D
Sbjct: 657 VRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVD-- 714
Query: 205 VVAIPYGSRHIRL--VLKGPDHLYLETKTLQG--TKGENSLSSTGTFLVDNSSVDFQKFP 260
V IP G+R IR+ V + + L L ++ + G ++ G + V ++ + +
Sbjct: 715 VGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRG 774
Query: 261 DKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR--------------WRETDF 306
+ E L GP +++ S + Y+ IHR W +
Sbjct: 775 NWENLTSPGPTKEPVWIQLLFQESNPG----VHYEYTIHREAGGHDEVPPPVFSWHYGPW 830
Query: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYK 366
C+ TCG G Q + C + R V +++C +P + ++C+ PCPA
Sbjct: 831 TKCTVTCGRGVQRQNVYCLE-RQAGPVDEEHCDPLG---RPDDQQRKCSEQPCPA----- 881
Query: 367 QIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
RW A W CSSSCG GG+ RAV C+ +++E C + P+
Sbjct: 882 ------------RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPR 929
Query: 426 MPIAQPCN-IFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIK 483
P PCN CP W WS C+VTCG+G + R VLC + G+ C +P +
Sbjct: 930 PPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV---PCDEAQQPASE 986
Query: 484 EECIVP 489
C +P
Sbjct: 987 VTCSLP 992
Score = 119 bits (297), Expect = 3e-26
Identities = 89/286 (31%), Positives = 127/286 (44%), Gaps = 35/286 (12%)
Query: 1484 LVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIA-CNR 1542
LV+++ W + CS +CG V +P +RC E CA RP QP C+
Sbjct: 1408 LVVRNAGWQAGNWSECSTTCGLGAVWRP-VRCSSGRDE----DCAPAGRP--QPARRCHL 1460
Query: 1543 RDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQAC 1602
R C + W +WS C+RSCGGG R V C + P+ C +P + C
Sbjct: 1461 RPCAT-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDL---RPLRPFHCQPGPAKPPAHRPC 1516
Query: 1603 NQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCW 1662
Q C+ W SSW +C+ C G Q R V C G+ C RP +T+ C
Sbjct: 1517 GAQPCLSWYTSSWRECSEACGGGE---QQRLVTCP-EPGL------CEEALRPNTTRPCN 1566
Query: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEH---LCSWGPRPANWQR 1719
+ C+ W V W C+ CG G Q R V+CV+ +T +PE C P + +
Sbjct: 1567 THPCT-QWVVGPWGQCSGPCGG-GVQRRLVKCVNTQTG--LPEEDSDQCGHEAWPESSRP 1622
Query: 1720 CNITPCENMECRDTTR------YCEKVKQLKLCQLSQFKSRCCGTC 1759
C CE +E R +CE ++ L CQL +++CC +C
Sbjct: 1623 CGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSC 1668
Score = 117 bits (293), Expect = 1e-25
Identities = 62/151 (41%), Positives = 78/151 (51%), Gaps = 6/151 (3%)
Query: 608 LYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
++ W Y +TKC+ +CG GVQ V CL +Q P +E C RP + C+ PCP
Sbjct: 822 VFSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 668 ARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELCRQ-PKPSTVQACNR 725
ARW G+W CS +CG GL R V C + S ++E L C P+P T CNR
Sbjct: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLC--IRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
Query: 726 -FNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
CP W W CS TCG G Q+R VLC
Sbjct: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLC 969
Score = 107 bits (267), Expect = 1e-22
Identities = 76/241 (31%), Positives = 107/241 (44%), Gaps = 29/241 (12%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARW 670
W+ +++CS +CG G V C + + + C + RP Q + C+L PC A W
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRP-QPARRCHLRPC-ATW 1466
Query: 671 EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP 730
G WS CS +CG G RDV C +R++ L C QP P+ A P
Sbjct: 1467 HSGNWSKCSRSCGGGSSVRDVQCVD--TRDLRP---LRPFHC-QPGPAKPPAHRPCGAQP 1520
Query: 731 --AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDC 788
+WY + W+ CS CGGG Q+R V C + P A +P + C C
Sbjct: 1521 CLSWYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNTTRPCNTHPC 1570
Query: 789 PSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLAT 848
++W++ W +CS CG G Q R C +TGL +S C + S RPC
Sbjct: 1571 -TQWVVGPWGQCSGPCGGGVQRRLVKCVN-TQTGLPE-EDSDQCGHEAWPESSRPCGTED 1627
Query: 849 C 849
C
Sbjct: 1628 C 1628
Score = 101 bits (251), Expect = 7e-21
Identities = 56/186 (30%), Positives = 90/186 (48%), Gaps = 21/186 (11%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
W G W+ C++TCG G+Q ++V+C + ++E D L R + C+ CP
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEH--CDPLGRPDDQQ--RKCSEQPCP 880
Query: 730 PAWYPAQWQPCSRTCG-GGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKD- 786
W+ +WQ CS +CG GG+ +R VLC + + L C +P + C +
Sbjct: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHV 940
Query: 787 DCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCML 846
CP+ W + +W++CS +CGEGTQ R+ +C N T +P + +P
Sbjct: 941 PCPATWAVGNWSQCSVTCGEGTQRRNVLC-----------TNDT---GVPCDEAQQPASE 986
Query: 847 ATCARP 852
TC+ P
Sbjct: 987 VTCSLP 992
Score = 99.8 bits (247), Expect = 2e-20
Identities = 74/259 (28%), Positives = 94/259 (36%), Gaps = 51/259 (19%)
Query: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
WS C+ TCG+G R VRC S D P+PA R C+ PC+
Sbjct: 1420 WSECSTTCGLGAVWRPVRCS-------SGRDEDCAPAGRPQPA--RRCHLRPCA------ 1464
Query: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVT 650
W ++KCS SCGGG V C++ + P C
Sbjct: 1465 -------------------TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQP 1505
Query: 651 SRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADE 710
P + C PC W W CS CG G Q R V C
Sbjct: 1506 GPAKPPAHRPCGAQPC-LSWYTSSWRECSEACGGGEQQRLVTCPE-------------PG 1551
Query: 711 LCRQP-KPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPE 769
LC + +P+T + CN C W W CS CGGGVQ+R V C G E +
Sbjct: 1552 LCEEALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQT-GLPEEDSD 1609
Query: 770 TFCSASKPACQQACKKDDC 788
+ P + C +DC
Sbjct: 1610 QCGHEAWPESSRPCGTEDC 1628
Score = 86.3 bits (212), Expect = 2e-16
Identities = 58/187 (31%), Positives = 74/187 (39%), Gaps = 30/187 (16%)
Query: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP-KPSTVQACNRF 726
A W+ G WS CS TCG+G R V CS DE C +P + C+
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSS-----------GRDEDCAPAGRPQPARRCHLR 1461
Query: 727 NCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC--SASKPACQQACK 784
C W+ W CSR+CGGG R+V C + L C +KP + C
Sbjct: 1462 PC-ATWHSGNWSKCSRSCGGGSSVRDVQC---VDTRDLRPLRPFHCQPGPAKPPAHRPCG 1517
Query: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPC 844
C S W S W ECS +CG G Q R C + LC ++ RPC
Sbjct: 1518 AQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE-----------PGLCEEALRPNTTRPC 1565
Query: 845 MLATCAR 851
C +
Sbjct: 1566 NTHPCTQ 1572
Score = 85.9 bits (211), Expect = 3e-16
Identities = 46/165 (27%), Positives = 69/165 (41%), Gaps = 32/165 (19%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W ++ CS +CGGG + +C D R R + +C P KP P + C PC
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQ--PGPAKP-PAHRPCGAQPCL 1522
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
+ W + W CS +CGGG Q R V+C E + C
Sbjct: 1523 S------------------WYTSSWRECSEACGGGEQQRLVTCPEPGL-----------C 1553
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCID 465
+ +PCN C +W+ W C+ CG G++ R+V C++
Sbjct: 1554 EEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
Score = 85.5 bits (210), Expect = 4e-16
Identities = 68/231 (29%), Positives = 93/231 (40%), Gaps = 30/231 (12%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNST-EVNPAHCAGKVRPAVQPIACNRRDCPSRW 1549
W C+ +CG RGVQ+ + CL V+ HC RP Q C+ + CP+RW
Sbjct: 825 WHYGPWTKCTVTCG-RGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
Query: 1550 MVTSWSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL-C 1607
W C+ SCG GG+ R V C + + + C + + P +T CN+ + C
Sbjct: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTET-PCNRHVPC 942
Query: 1608 -VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC 1666
WA +W QC+ C Q R V C G+ C +P S C C
Sbjct: 943 PATWAVGNWSQCSVTC---GEGTQRRNVLCTNDTGV-----PCDEAQQPASEVTCSLPLC 994
Query: 1667 SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA--VPEHLCSWGPRPA 1715
W L T G G S H N+A +P HL PRP+
Sbjct: 995 R-------WPL--GTLGPEG--SGSGSSSHELFNEADFIPHHL---APRPS 1031
Score = 79.7 bits (195), Expect = 2e-14
Identities = 57/191 (29%), Positives = 74/191 (38%), Gaps = 43/191 (22%)
Query: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE--GPKPASQRACYAGPCSGEIP 588
W+ CTVTCG G Q + V C + + + C+ G QR C PC
Sbjct: 830 WTKCTVTCGRGVQRQNVYC-----LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPAR-- 882
Query: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCG-GGVQEAVVSCLNK---QTREPAE 644
W + CS SCG GG+ V C+ + E
Sbjct: 883 ----------------------WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALE 920
Query: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
C RPP PCPA W +G WS CS+TCG G Q R+V C+ N+T
Sbjct: 921 PPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCT-------NDT 973
Query: 705 VILADELCRQP 715
+ DE +QP
Sbjct: 974 GVPCDE-AQQP 983
Score = 79.0 bits (193), Expect = 4e-14
Identities = 69/285 (24%), Positives = 100/285 (35%), Gaps = 73/285 (25%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ ++ CS TCG G C R D+ C P +P+P + C+L PC
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR------DEDCA--PAG-RPQPA-RRCHLRPCA 1464
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
W + W+ CS SCGGG R V CV+ + + + C
Sbjct: 1465 T------------------WHSGNWSKCSRSCGGGSSVRDVQCVD---TRDLRPLRPFHC 1503
Query: 421 MYTP-KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
P K P +PC C W W C+ CG G + R+V C + G C +
Sbjct: 1504 QPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPE-----PGLCEEALR 1558
Query: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
P+ C PC ++ W C+ CG
Sbjct: 1559 PNTTRPCNT-HPC-------------------------------TQWVVGPWGQCSGPCG 1586
Query: 540 VGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPC 583
G Q R+V+C ++ + + D+C P S R C C
Sbjct: 1587 GGVQRRLVKC---VNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 69.7 bits (169), Expect = 2e-11
Identities = 39/121 (32%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 729 PP--AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQ-ACK 784
PP +W+ W C+ TCG GVQ++ V C +R A + E C +P QQ C
Sbjct: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAG----PVDEEHCDPLGRPDDQQRKCS 875
Query: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAI-CRKMLKTGLSTVVNSTLCPPLPFSSSIRP 843
+ CP+ W +W CS+SCG G +R A+ C + + + + C LP + P
Sbjct: 876 EQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETP 935
Query: 844 C 844
C
Sbjct: 936 C 936
Score = 41.2 bits (95), Expect = 0.009
Identities = 39/135 (28%), Positives = 53/135 (39%), Gaps = 35/135 (25%)
Query: 535 TVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE-FNPD 593
T+ C VGT S D +D G + + C +G C +P F P+
Sbjct: 494 TLWCSVGTTCH------------SKLDAAVD---GTRCGENKWCLSGEC---VPVGFRPE 535
Query: 594 ETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR 653
DG + G + ++ CS SCG GVQ A C Q + CV R+
Sbjct: 536 AVDGGWSG-----------WSAWSICSRSCGMGVQSAERQC--TQPTPKYKGRYCVGERK 582
Query: 654 PPQLLKSCNLDPCPA 668
+L CNL CPA
Sbjct: 583 RFRL---CNLQACPA 594
Score = 38.9 bits (89), Expect = 0.045
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 3/57 (5%)
Query: 1670 WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQR-CNITPC 1725
W WT CT TCG G Q + V C+ + EH C RP + QR C+ PC
Sbjct: 825 WHYGPWTKCTVTCGR-GVQRQNVYCLERQAGPVDEEH-CDPLGRPDDQQRKCSEQPC 879
Score = 35.4 bits (80), Expect = 0.49
Identities = 22/62 (35%), Positives = 28/62 (45%), Gaps = 14/62 (22%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQ 91
R+ W A G WSECS TCG GA + RC S + + DC P A+
Sbjct: 1411 RNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGR-------------DEDCAPAGRPQPAR 1456
Query: 92 QC 93
+C
Sbjct: 1457 RC 1458
Score = 35.0 bits (79), Expect = 0.65
Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 11/55 (20%)
Query: 40 GPWSECSRTCGGGASYSLRRCLS---------SKSC--EGRNIRYRTCSNVDCPP 83
GPW +CS CGGG L +C++ S C E R C DC P
Sbjct: 1576 GPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
Score = 33.9 bits (76), Expect = 1.4
Identities = 12/25 (48%), Positives = 19/25 (76%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSK 64
G WS+CSR+CGGG+S +C+ ++
Sbjct: 1469 GNWSKCSRSCGGGSSVRDVQCVDTR 1493
Score = 31.2 bits (69), Expect = 9.3
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 10/57 (17%)
Query: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTP-VSNDMCTQVAKRPVDTQACNQQLC 1607
++WS C+RSCG GVQ+ C + TP C KR + CN Q C
Sbjct: 545 SAWSICSRSCGMGVQSAERQCTQ------PTPKYKGRYCVGERKR---FRLCNLQAC 592
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 218 bits (554), Expect = 5e-56
Identities = 143/469 (30%), Positives = 213/469 (45%), Gaps = 63/469 (13%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEA 85
RDG W AW P+ CSRTCG G + R+C + ++C G ++ CS DCP
Sbjct: 560 RDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSL 619
Query: 86 GDFRAQQCSA------HNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKV 138
DFR +QC H D +HH WLP + D C L C+++ T VV + V
Sbjct: 620 ADFREEQCRQWDLYFEHGDAQHH-----WLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
Query: 139 LDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLS 197
DGTRC Y ++ +C+ G C+ VGCD +GS+ +ED CGVC GD S C++V+G + ++
Sbjct: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTF-TRSP 733
Query: 198 ATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTK----GENSL-SSTGTFLVDNS 252
+ IP G+RH+ + +L K L+ K EN + +S+ TF+
Sbjct: 734 KKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGV 793
Query: 253 SVDFQKFPDKEILRMAGPLTADFIVKIRNSGS--ADSTVQFIFYQ--------------P 296
+++ +E L+ GPL V + G T +++ ++
Sbjct: 794 EWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDS 853
Query: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
+++ W + PCS CGGG Q T C +++V +C KPK + CN
Sbjct: 854 VVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALS---KPKAIRRACNP 910
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSV 415
C P W W CS +CG G+Q R+V C++ SV
Sbjct: 911 QECSQ----------------PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSV 954
Query: 416 EEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
C + + C+ CP +W A WS C+VTCG G + R VLC
Sbjct: 955 HAKHC-NDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC 1002
Score = 113 bits (282), Expect = 2e-24
Identities = 55/150 (36%), Positives = 77/150 (51%), Gaps = 7/150 (4%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQ-ACNRFNC 728
W + KWSPCS CG G Q C L +M A KP ++ ACN C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCA----ALSKPKAIRRACNPQEC 913
Query: 729 P-PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKD 786
P W +W+PCS+TCG G+Q R V C Q + D + + C+ ++P ++AC ++
Sbjct: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRE 973
Query: 787 DCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
CP W W++CS +CG GTQ R +CR
Sbjct: 974 LCPGRWRAGPWSQCSVTCGNGTQERPVLCR 1003
Score = 85.1 bits (209), Expect = 5e-16
Identities = 56/233 (24%), Positives = 87/233 (37%), Gaps = 64/233 (27%)
Query: 439 KWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPHIKEECIVPTPCYKP 495
+W ++WSPC+ CG G ++ C +DH+ +H G C+ +KP P C
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC--- 913
Query: 496 KEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRCQVLLS 554
+P ++ W C+ TCG G QVR VRC +
Sbjct: 914 --------------------------SQPVWVTGEWEPCSQTCGRTGMQVRSVRC-IQPL 946
Query: 555 FSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYE 614
+ + C +P S+RAC C G W
Sbjct: 947 HDNTTRSVHAKHCNDARPESRRACSRELCPGR------------------------WRAG 982
Query: 615 GFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
+++CS +CG G QE V C A+++ + P+ ++C L PCP
Sbjct: 983 PWSQCSVTCGNGTQERPVLC------RTADDSFGICQEERPETARTCRLGPCP 1029
Score = 81.3 bits (199), Expect = 8e-15
Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 14/181 (7%)
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W + WS C++ CGGG Q + C++ + V C ++K +ACN Q C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKM---VHRGFCAALSKPKAIRRACNPQECS 914
Query: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGIT--LPSEQCSALPRPVSTQNCWSE 1664
+ W W C+ C + V+ + D T + ++ C+ RP S + C E
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRE 973
Query: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
C WR W+ C+ TCGN G Q R V C A + + + RP + C + P
Sbjct: 974 LCPGRWRAGPWSQCSVTCGN-GTQERPVLCRTADDSFGICQE-----ERPETARTCRLGP 1027
Query: 1725 C 1725
C
Sbjct: 1028 C 1028
Score = 77.8 bits (190), Expect = 9e-14
Identities = 60/219 (27%), Positives = 83/219 (37%), Gaps = 51/219 (23%)
Query: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDC-- 437
W W+ CS CGGG Q C H + + I + CN +C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRR--LDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
Query: 438 PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDH------RGMHTGGCSPKTKPHIKEECIVPT 490
P W+ EW PC+ TCG+ G++ R V CI R +H C+ +P + C
Sbjct: 916 PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRAC---- 970
Query: 491 PCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQ 550
++EL G + WS C+VTCG GTQ R V C+
Sbjct: 971 --------------------SRELCPGR-------WRAGPWSQCSVTCGNGTQERPVLCR 1003
Query: 551 VLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE 589
AD C+ +P + R C GPC I +
Sbjct: 1004 T--------ADDSFGICQEERPETARTCRLGPCPRNISD 1034
Score = 75.5 bits (184), Expect = 4e-13
Identities = 61/220 (27%), Positives = 87/220 (39%), Gaps = 43/220 (19%)
Query: 514 LEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPA 573
LEE + V E + + WS C+ CG G+Q C+ L PK A
Sbjct: 849 LEEDSVVYE---WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGF-CAALSKPK-A 903
Query: 574 SQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVV 632
+RAC CS + W + CS++CG G+Q V
Sbjct: 904 IRRACNPQECSQPV-----------------------WVTGEWEPCSQTCGRTGMQVRSV 940
Query: 633 SC---LNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTR 689
C L+ T C +R P+ ++C+ + CP RW G WS CS+TCG G Q R
Sbjct: 941 RCIQPLHDNTTRSVHAKHCNDAR--PESRRACSRELCPGRWRAGPWSQCSVTCGNGTQER 998
Query: 690 DVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
V C T + +C++ +P T + C CP
Sbjct: 999 PVLC---------RTADDSFGICQEERPETARTCRLGPCP 1029
Score = 72.8 bits (177), Expect = 3e-12
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 11/157 (7%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCL--LNSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
Y W++ + + CS CG G Q + C L+ V+ CA +P ACN ++C
Sbjct: 856 YEWALKKWSPCSKPCGG-GSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 1547 SR-WMVTSWSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
W+ W C+++CG G+Q R V C + + V C RP +AC++
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA--RPESRRACSR 972
Query: 1605 QLCV-EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD 1640
+LC W W QC+ C Q R V C+T D
Sbjct: 973 ELCPGRWRAGPWSQCSVTCGN---GTQERPVLCRTAD 1006
Score = 56.6 bits (135), Expect = 2e-07
Identities = 45/141 (31%), Positives = 59/141 (41%), Gaps = 26/141 (18%)
Query: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPSEQCSALPRPVSTQN-CWSEAC 1666
EWA W C+ PC G Q + C+ R D + C+AL +P + + C + C
Sbjct: 857 EWALKKWSPCSKPCGG---GSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
Query: 1667 SVH-WRVSLWTLCTATCGNYGFQSRRVEC-----------VHAR-TNKAVPE-------H 1706
S W W C+ TCG G Q R V C VHA+ N A PE
Sbjct: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRE 973
Query: 1707 LCSWGPRPANWQRCNITPCEN 1727
LC R W +C++T C N
Sbjct: 974 LCPGRWRAGPWSQCSVT-CGN 993
Score = 38.5 bits (88), Expect = 0.058
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 4/95 (4%)
Query: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI-R 842
++D EW L W+ CS CG G+Q CR+ L +V+ C L +I R
Sbjct: 850 EEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLD---HKMVHRGFCAALSKPKAIRR 906
Query: 843 PCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQR 877
C C++P + + P + +Q R R
Sbjct: 907 ACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVR 941
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 214 bits (546), Expect = 5e-55
Identities = 145/485 (29%), Positives = 223/485 (45%), Gaps = 54/485 (11%)
Query: 27 RSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVD 80
+ E G W W PWS CSRTCG G + R C K C G RYR C+
Sbjct: 536 KKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHP 595
Query: 81 CPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
C EA FR QCS + V + + Y W P+ N P +PC L C+ ++ V+D
Sbjct: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFN-PAHPCELYCRPIDGQFSEKMLDAVID 654
Query: 141 GTRCYT--ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
GT C+ S ++CI+G+C++VGCD+++ S ED CGVC GDGS+C+ VR +K + +
Sbjct: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
Query: 199 TKSDDTVVAIPYGSRHIRLV-LKGPDHLYLETKTLQGTK----GENSLSSTGTFLVDNSS 253
D + IP G+R IR++ ++G + +L ++ K G + G + + +
Sbjct: 715 GYVD--IGLIPKGARDIRVMEIEGAGN-FLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTV 771
Query: 254 VDFQKFPDKEILRMAGP----LTADFIVKIRNSG-SADSTVQFIFYQPIIHR----WRET 304
+ + D E L GP + + ++ N G + T+Q + + W+
Sbjct: 772 FQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYG 831
Query: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
+ CS TCG G + +A C + +V +C PE +P + ++C+ CP
Sbjct: 832 HWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCD--PET-QPNGRQKKCHEKACP---- 883
Query: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYT 423
PRW A W ACS++CG G + R V C++ + ++ C +
Sbjct: 884 -------------PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHL 929
Query: 424 PKMPIAQPCN-IFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPH 481
K CN CP W WS C+V+CG G+R R V C + H C KP+
Sbjct: 930 LKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN---HDEPCDVTRKPN 986
Query: 482 IKEEC 486
+ C
Sbjct: 987 SRALC 991
Score = 137 bits (345), Expect = 9e-32
Identities = 86/277 (31%), Positives = 126/277 (45%), Gaps = 30/277 (10%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W V + CS +CG G R+ C ST+++ + CA RP C+ R C W
Sbjct: 1317 WIVGNWSECSTTCG-LGAYWRRVEC---STQMD-SDCAAIQRPDPAK-RCHLRPCAG-WK 1369
Query: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEW 1610
V +WS C+R+C GG + R + C + P + P + +CN + C W
Sbjct: 1370 VGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIP--PPLSMSCNPEPCEAW 1427
Query: 1611 AFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHW 1670
W QC+ C G VQ R VFC P C RP ST +C C HW
Sbjct: 1428 QVEPWSQCSRSCGG---GVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLCC-HW 1475
Query: 1671 RVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEH--LCSWGPRPANWQRCNITPCE-- 1726
W LC+ +CG GFQ R V+CV + NK + LC PRP +++CN C+
Sbjct: 1476 ATGNWDLCSTSCGG-GFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKS 1534
Query: 1727 -NMECRD---TTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
++ C + +C+ +K +K C + ++ CC +C
Sbjct: 1535 ADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 108 bits (271), Expect = 4e-23
Identities = 79/269 (29%), Positives = 113/269 (42%), Gaps = 43/269 (15%)
Query: 594 ETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR 653
+ DGL ++ ++Y W+Y +T+CS +CG G++ C+ K+ R + C +
Sbjct: 813 QKDGLDNDVEQ--QMYFWQYGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQ 869
Query: 654 PPQLLKSCNLDPCPARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELC 712
P K C+ CP RW G+W CS TCG G + R V C + + +E + +
Sbjct: 870 PNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLC--IQTMVSDEQALPPTDCQ 927
Query: 713 RQPKPSTVQACNR-FNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETF 771
KP T+ +CNR CP W W CS +CGGGV+ R V C + E
Sbjct: 928 HLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH--------DEPC 979
Query: 772 CSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTL 831
KP + C CPS R++LK T+ N
Sbjct: 980 DVTRKPNSRALCGLQQCPSS------------------------RRVLKPNKGTISNGKN 1015
Query: 832 CP---PLPFSSSIRPCMLATCARPGRPST 857
P P+P +S RP ML T P ST
Sbjct: 1016 PPTLKPVPPPTS-RPRMLTTPTGPESMST 1043
Score = 105 bits (263), Expect = 3e-22
Identities = 71/242 (29%), Positives = 100/242 (41%), Gaps = 26/242 (10%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARW 670
W +++CS +CG G V C + + C +RP K C+L PC A W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPA-KRCHLRPC-AGW 1368
Query: 671 EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP 730
++G WS CS C G + R++ C SR+ + P +CN C
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVD--SRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE- 1425
Query: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPS 790
AW W CSR+CGGGVQ+R V C + D + +P +C + C
Sbjct: 1426 AWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWT-----------KRPTSTMSCNEHLC-C 1473
Query: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTV-VNSTLCPPLPFSSSIRPCMLATC 849
W +W CSTSCG G Q R+ C + G T + LC P + C C
Sbjct: 1474 HWATGNWDLCSTSCGGGFQKRTVQC--VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Query: 850 AR 851
+
Sbjct: 1532 KK 1533
Score = 94.0 bits (232), Expect = 1e-18
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 38/210 (18%)
Query: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
W+ ++ CS C GG+++ +C D R +R + +C + P P CN +PC
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--PPPLSMSCNPEPCE 1425
Query: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
A W+ PW+ CS SCGGG+Q R V C C
Sbjct: 1426 A------------------WQVEPWSQCSRSCGGGVQERGVFC------------PGGLC 1455
Query: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG-----CS 475
+T + CN C W W C+ +CG G + R V C+ G T C
Sbjct: 1456 DWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCD 1515
Query: 476 PKTKPHIKEECIVPTPCYKPKEKLPVEAKL 505
K +P ++C C K + L + KL
Sbjct: 1516 HKPRPPEFKKC-NQQACKKSADLLCTKDKL 1544
Score = 86.7 bits (213), Expect = 2e-16
Identities = 44/148 (29%), Positives = 61/148 (41%), Gaps = 12/148 (8%)
Query: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFN 727
A W +G WS CS TCG+G R V CS + + +P + C+
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQMD----------SDCAAIQRPDPAKRCHLRP 1364
Query: 728 CPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
C W W CSR C GG + RE+ C + F + P +C +
Sbjct: 1365 C-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 788 CPSEWLLSDWTECSTSCGEGTQTRSAIC 815
C + W + W++CS SCG G Q R C
Sbjct: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC 1450
Score = 80.1 bits (196), Expect = 2e-14
Identities = 68/299 (22%), Positives = 100/299 (33%), Gaps = 86/299 (28%)
Query: 375 HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNI 434
H W W+ CS++CG G R V C ++ + C + A+ C++
Sbjct: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVEC---------STQMDSDCAAIQRPDPAKRCHL 1362
Query: 435 FDCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCS--PKTKPHIKEECIVP 489
C W WS C+ C G + R + C+ DHR + C P + C P
Sbjct: 1363 RPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC-NP 1421
Query: 490 TPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRC 549
PC ++ E WS C+ +CG G Q R V C
Sbjct: 1422 EPC-------------------------------EAWQVEPWSQCSRSCGGGVQERGVFC 1450
Query: 550 QVLLSFSQSVADLPIDECEGPK-PASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDEL 608
P C+ K P S +C C
Sbjct: 1451 -------------PGGLCDWTKRPTSTMSCNEHLCC------------------------ 1473
Query: 609 YDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRP-PQLLKSCNLDPC 666
W + CS SCGGG Q+ V C+ + + +++ C+ +P P K CN C
Sbjct: 1474 -HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 72.4 bits (176), Expect = 4e-12
Identities = 52/190 (27%), Positives = 77/190 (40%), Gaps = 15/190 (7%)
Query: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE-VNPAHCAGKVRPAVQPIACNRRDC 1545
Q Y+W CS +CG G+++ C+ V C + +P + C+ + C
Sbjct: 824 QMYFWQYGHWTECSVTCGT-GIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC 882
Query: 1546 PSRWMVTSWSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
P RW W AC+ +CG G + R V C + S D C + K P +CN+
Sbjct: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQHLLK-PKTLLSCNR 940
Query: 1605 Q-LC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCW 1662
LC +W +W +C+ C G V+ R V C E C +P S C
Sbjct: 941 DILCPSDWTVGNWSECSVSCGG---GVRIRSVTCAKNH-----DEPCDVTRKPNSRALCG 992
Query: 1663 SEACSVHWRV 1672
+ C RV
Sbjct: 993 LQQCPSSRRV 1002
Score = 63.9 bits (154), Expect = 1e-09
Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 18/182 (9%)
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W W+ C+ +CG G++ + C K K G+ D TQ R + C+++ C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCDPETQPNGRQ---KKCHEKACP 883
Query: 1609 -EWAFSSWGQCNGPCIGPHLAVQHRQVFC---QTRDGITLPSEQCSALPRPVSTQNCWSE 1664
W W C+ C GPH + R V C D LP C L +P + +C +
Sbjct: 884 PRWWAGEWEACSATC-GPH-GEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRD 941
Query: 1665 A-CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
C W V W+ C+ +CG G + R V C + C +P + C +
Sbjct: 942 ILCPSDWTVGNWSECSVSCGG-GVRIRSVTCAKNH------DEPCDVTRKPNSRALCGLQ 994
Query: 1724 PC 1725
C
Sbjct: 995 QC 996
Score = 63.5 bits (153), Expect = 2e-09
Identities = 56/205 (27%), Positives = 83/205 (40%), Gaps = 46/205 (22%)
Query: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
W+ C+VTCG G + + C + + + + E Q+ C+ C P +
Sbjct: 833 WTECSVTCGTGIRRQTAHC---IKKGRGMVKATFCDPETQPNGRQKKCHEKACP---PRW 886
Query: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCLNKQTREPAEENLCV 649
E WE CS +CG G ++ V C+ QT E+ L
Sbjct: 887 WAGE----------------WE-----ACSATCGPHGEKKRTVLCI--QTMVSDEQALPP 923
Query: 650 TSRR---PPQLLKSCNLDP-CPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETV 705
T + P+ L SCN D CP+ W +G WS CS++CG G++ R V C+
Sbjct: 924 TDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK---------- 973
Query: 706 ILADELCR-QPKPSTVQACNRFNCP 729
DE C KP++ C CP
Sbjct: 974 -NHDEPCDVTRKPNSRALCGLQQCP 997
Score = 60.8 bits (146), Expect = 1e-08
Identities = 36/129 (27%), Positives = 56/129 (43%), Gaps = 12/129 (9%)
Query: 1600 QACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQ 1659
Q N W +W +C+ C L R+V C T+ C+A+ RP +
Sbjct: 1307 QLTNGHGSAHWIVGNWSECSTTC---GLGAYWRRVECSTQ-----MDSDCAAIQRPDPAK 1358
Query: 1660 NCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSW--GPRPANW 1717
C C+ W+V W+ C+ C GF+ R ++CV +R ++ + C + G P
Sbjct: 1359 RCHLRPCA-GWKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLS 1416
Query: 1718 QRCNITPCE 1726
CN PCE
Sbjct: 1417 MSCNPEPCE 1425
Score = 38.1 bits (87), Expect = 0.076
Identities = 49/196 (25%), Positives = 76/196 (38%), Gaps = 40/196 (20%)
Query: 648 CVTSRRPPQLLKSCNLDPCPARWEIGKWSP---CSLTCGVGLQTRDVFCSH--------L 696
C+T + P+ + P W G+WSP CS TCG G+Q+ + C++
Sbjct: 531 CITVGKKPESI--------PGGW--GRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKY 580
Query: 697 LSREMNETVILADELCRQPKPSTVQ-ACNRFNCPP------AWYPA--QWQPCSRTCGGG 747
+ E + CR P+ Q C+ F+ P W+P PC C
Sbjct: 581 CTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYC--- 637
Query: 748 VQKREVLCKQRMADGSFLELPETFCSASKPAC-QQACKKDDCPSEWLLSDWTE--CSTSC 804
+ + ++M D P S+ C CK C E + S+ TE C
Sbjct: 638 -RPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYE-IDSNATEDRCGVCL 695
Query: 805 GEGTQTRSAICRKMLK 820
G+G+ ++ RKM K
Sbjct: 696 GDGSSCQTV--RKMFK 709
Score = 36.2 bits (82), Expect = 0.29
Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 9/61 (14%)
Query: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
+ W++ +W+ECST+CG G R C ST ++S C + + C L C
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSD-CAAIQRPDPAKRCHLRPC 1365
Query: 850 A 850
A
Sbjct: 1366 A 1366
Score = 35.0 bits (79), Expect = 0.65
Identities = 35/135 (25%), Positives = 54/135 (40%), Gaps = 25/135 (18%)
Query: 549 CQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCS--GEIPEFNPDETDGLFGGLQDF 605
CQ L + +D +G + ++ C AG C G+ PE P GG
Sbjct: 496 CQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIP-------GG---- 544
Query: 606 DELYDW-EYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLD 664
W + ++ CS +CG GVQ A C N + + + C R+ +L CN+
Sbjct: 545 -----WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGK--YCTGERKRYRL---CNVH 594
Query: 665 PCPARWEIGKWSPCS 679
PC + + CS
Sbjct: 595 PCRSEAPTFRQMQCS 609
Score = 34.7 bits (78), Expect = 0.84
Identities = 18/62 (29%), Positives = 26/62 (41%)
Query: 38 AWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHN 97
A G W CS +CGGG +C+ S+ + + C + PPE Q C
Sbjct: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
Query: 98 DV 99
D+
Sbjct: 1536 DL 1537
Score = 32.7 bits (73), Expect = 3.2
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 11/54 (20%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCS---------NVDCPPE 84
G WS+CSR C GG +C+ S+ + RN+R C ++ C PE
Sbjct: 1371 GNWSKCSRNCSGGFKIREIQCVDSR--DHRNLRPFHCQFLAGIPPPLSMSCNPE 1422
Score = 32.3 bits (72), Expect = 4.2
Identities = 12/18 (66%), Positives = 15/18 (83%), Gaps = 2/18 (11%)
Query: 37 DAWG--PWSECSRTCGGG 52
+AW PWS+CSR+CGGG
Sbjct: 1425 EAWQVEPWSQCSRSCGGG 1442
Score = 31.6 bits (70), Expect = 7.1
Identities = 27/98 (27%), Positives = 35/98 (35%), Gaps = 14/98 (14%)
Query: 520 VSEEPSFIP------EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPA 573
V ++P IP WS C+ TCG G Q C + C G +
Sbjct: 534 VGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLC------NNPEPKFGGKYCTGER-K 586
Query: 574 SQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDW 611
R C PC E P F + F + +ELY W
Sbjct: 587 RYRLCNVHPCRSEAPTFRQMQCSE-FDTVPYKNELYHW 623
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 213 bits (541), Expect = 2e-54
Identities = 145/499 (29%), Positives = 220/499 (44%), Gaps = 71/499 (14%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEA 85
+DG W +W + CSR+CGGG R C + C G Y+ C++ +CP
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610
Query: 86 GDFRAQQCSAHNDVK-HHGQFYEWLPVSNDPD-NPCSLKCQAKGTTLVVELAPKVLDGTR 143
DFRAQQC+ N H + W+P D D C L CQ+ T VV + V DGTR
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 670
Query: 144 C-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVR---GQYKSQLSAT 199
C Y + +C G C VGCD ++GS +D CGVC GD S CR V+ G+ Q A
Sbjct: 671 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 730
Query: 200 KSDDTVVAIPYGSRHIRL--VLKGPDHLYLETKT----LQGTKGENSLSSTGTFLVDNSS 253
K +V IP G+RHI++ + K P + ++ + + KG+ + S T T +
Sbjct: 731 K----LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAM----G 782
Query: 254 VDFQKFPD--KEILRMAGPLTADFIV----KIRNSGSADSTVQFIFYQPII--------- 298
++++ + KE L+ +GPL + + +++ ++ ++
Sbjct: 783 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 842
Query: 299 ------HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQ 352
+ W + PCS CGGG Q T C R + +V C + +PKP +
Sbjct: 843 LEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRR 899
Query: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGH 411
CN PC P W W ACS SCG G+Q+R + C+ +
Sbjct: 900 RCNQHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCL-LPLSNG 942
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
V K + +PC CP +W WS C+ TCG+G++ R V+C +
Sbjct: 943 THKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC--RTNAN 1000
Query: 471 TGGCSPKTKPHIKEECIVP 489
+ G +P + C +P
Sbjct: 1001 SLGHCEGDRPDTVQVCSLP 1019
Score = 114 bits (284), Expect = 1e-24
Identities = 56/177 (31%), Positives = 88/177 (49%), Gaps = 6/177 (3%)
Query: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
+ Y+W + + CS++CGGG+Q C ++ + +LC +RP + + CN PC
Sbjct: 847 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906
Query: 667 PAR-WEIGKWSPCSLTCG-VGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN 724
W +W CS +CG +G+QTR + C LS ++ ++ + C +P + C
Sbjct: 907 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHK--VMPAKACAGDRPEARRPCL 964
Query: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE--LPETFCSASKPAC 779
R CP W W CS TCG G+Q+R+V+C+ E P+T S PAC
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPAC 1021
Score = 110 bits (275), Expect = 1e-23
Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 11/152 (7%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELC---RQPKPSTVQACNRF 726
W + W+PCS CG G+Q C R + ++ LC ++PKP + CN+
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGC-----RRRRDHHMVQRHLCDHKKRPKPIR-RRCNQH 904
Query: 727 NCP-PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
C P W +W CSR+CG GVQ R + C +++G+ +P C+ +P ++ C
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 964
Query: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
+ CP++W L W++CS +CGEG Q R +CR
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR 996
Score = 92.4 bits (228), Expect = 3e-18
Identities = 58/193 (30%), Positives = 87/193 (45%), Gaps = 18/193 (9%)
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W + SW+ C+++CGGG+Q + C++ + + V +C + + CNQ C
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHM---VQRHLCDHKKRPKPIRRRCNQHPCS 907
Query: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFC----QTRDGITLPSEQCSALPRPVSTQNCW 1662
+ W WG C+ C L VQ R + C +P++ C+ RP + + C
Sbjct: 908 QPVWVTEEWGACSRSC--GKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCL 964
Query: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
C WR+ W+ C+ATCG G Q R+V C RTN H C G RP Q C++
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGE-GIQQRQVVC---RTNANSLGH-CE-GDRPDTVQVCSL 1018
Query: 1723 TPCENMECRDTTR 1735
C T R
Sbjct: 1019 PACGGNHQNSTVR 1031
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/204 (29%), Positives = 80/204 (39%), Gaps = 40/204 (19%)
Query: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
++W+ C+ CG G Q C+ L D + PKP +R C PCS +
Sbjct: 854 KSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHL-CDHKKRPKPIRRR-CNQHPCSQPV- 910
Query: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCL---NKQTREPAE 644
W E + CS SCG GVQ + CL + T +
Sbjct: 911 ----------------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMP 948
Query: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
C R P+ + C PCPA+W +G WS CS TCG G+Q R V C T
Sbjct: 949 AKACAGDR--PEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC---------RT 997
Query: 705 VILADELCRQPKPSTVQACNRFNC 728
+ C +P TVQ C+ C
Sbjct: 998 NANSLGHCEGDRPDTVQVCSLPAC 1021
Score = 77.0 bits (188), Expect = 1e-13
Identities = 70/278 (25%), Positives = 102/278 (36%), Gaps = 36/278 (12%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRDCP 1546
Y W++ A CS +CG G+Q + C V C K RP CN+ C
Sbjct: 849 YEWALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 907
Query: 1547 SR-WMVTSWSACTRSCGG-GVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
W+ W AC+RSCG GVQTR + C ++G + C RP + C +
Sbjct: 908 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC--AGDRPEARRPCLR 965
Query: 1605 QLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
C +W +W QC+ C +Q RQV C+T E RP + Q C
Sbjct: 966 VPCPAQWRLGAWSQCSATC---GEGIQQRQVVCRTNANSLGHCEG----DRPDTVQVCSL 1018
Query: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
AC GN+ + R + T + W P+ N
Sbjct: 1019 PACG---------------GNHQNSTVRADVWELGTPEG------QWVPQSEPLHPINKI 1057
Query: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
D + +C+ + C + + CC +C K
Sbjct: 1058 SSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIK 1095
Score = 69.7 bits (169), Expect = 2e-11
Identities = 60/263 (22%), Positives = 97/263 (36%), Gaps = 80/263 (30%)
Query: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCSPKTKPH-IKEECIVPTP 491
D +W + W+PC+ CG G+++ C DH + C K +P I+ C P
Sbjct: 847 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCN-QHP 905
Query: 492 CYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRCQ 550
C +P ++ E W AC+ +CG +G Q R ++C
Sbjct: 906 C-----------------------------SQPVWVTEEWGACSRSCGKLGVQTRGIQCL 936
Query: 551 VLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYD 610
+ LS + + +P C G +P ++R C PC +
Sbjct: 937 LPLS-NGTHKVMPAKACAGDRPEARRPCLRVPCPAQ------------------------ 971
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPAR- 669
W +++CS +CG G+Q+ V C C R P ++ C+L C
Sbjct: 972 WRLGAWSQCSATCGEGIQQRQVVCRTNAN----SLGHCEGDR--PDTVQVCSLPACGGNH 1025
Query: 670 ---------WEI----GKWSPCS 679
WE+ G+W P S
Sbjct: 1026 QNSTVRADVWELGTPEGQWVPQS 1048
Score = 40.8 bits (94), Expect = 0.012
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 19/113 (16%)
Query: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
+G + A + C+ G C + PE +T G GG + + F CS SCGGGV
Sbjct: 525 DGTECAPGKWCFKGHCIWKSPE----QTYGQDGGWSSWTK--------FGSCSRSCGGGV 572
Query: 628 QEAVVSCLNKQTREPA-EENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCS 679
+ SC N PA LC+ P + CN + CP +E + C+
Sbjct: 573 RSRSRSCNNP---SPAYGGRLCL---GPMFEYQVCNSEECPGTYEDFRAQQCA 619
Score = 39.7 bits (91), Expect = 0.026
Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 2/75 (2%)
Query: 1652 LPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
LP S E + W + W C+ CG G Q + C R + V HLC
Sbjct: 833 LPLIGSNNVLLEEMDTYEWALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHK 891
Query: 1712 PRPAN-WQRCNITPC 1725
RP +RCN PC
Sbjct: 892 KRPKPIRRRCNQHPC 906
Score = 37.0 bits (84), Expect = 0.17
Identities = 53/227 (23%), Positives = 77/227 (33%), Gaps = 56/227 (24%)
Query: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEE---------NLCVTSRRPPQL 657
EL Y +C G G Q +CL +T EP ++ C T + PP
Sbjct: 470 ELPGINYSMDEQCRFDFGSGYQ----TCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLD 525
Query: 658 LKSCNLDPCPARW----------------EIGKWSP------CSLTCGVGLQTRDVFCSH 695
C P +W + G WS CS +CG G+++R C+
Sbjct: 526 GTEC----APGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCN- 580
Query: 696 LLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
N + LC P Q CN CP + + Q C+ KR
Sbjct: 581 ------NPSPAYGGRLCLGPM-FEYQVCNSEECPGTYEDFRAQQCA--------KRNSYY 625
Query: 756 KQRMADGSFLEL-PETFCSASKPACQQACKKDDCPSEWLLSDWTECS 801
+ A S++ P+ + CQ A D ++ D T CS
Sbjct: 626 VHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 672
Score = 33.5 bits (75), Expect = 1.9
Identities = 29/108 (26%), Positives = 43/108 (39%), Gaps = 10/108 (9%)
Query: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCP----PLPFSSSIRPCML 846
EW L W CS +CG G Q CR+ +V LC P P R C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR---RRCNQ 903
Query: 847 ATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTA 894
C++P + + + K+ +QTR + L + G ++P A
Sbjct: 904 HPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKA 951
Score = 32.0 bits (71), Expect = 5.5
Identities = 13/26 (50%), Positives = 19/26 (73%), Gaps = 2/26 (7%)
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTC 1572
S W T + +C+RSCGGGV++R +C
Sbjct: 556 SSW--TKFGSCSRSCGGGVRSRSRSC 579
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 213 bits (541), Expect = 2e-54
Identities = 145/499 (29%), Positives = 220/499 (44%), Gaps = 71/499 (14%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEA 85
+DG W +W + CSR+CGGG R C + C G Y+ C++ +CP
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Query: 86 GDFRAQQCSAHNDVK-HHGQFYEWLPVSNDPD-NPCSLKCQAKGTTLVVELAPKVLDGTR 143
DFRAQQC+ N H + W+P D D C L CQ+ T VV + V DGTR
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
Query: 144 C-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVR---GQYKSQLSAT 199
C Y + +C G C VGCD ++GS +D CGVC GD S CR V+ G+ Q A
Sbjct: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
Query: 200 KSDDTVVAIPYGSRHIRL--VLKGPDHLYLETKT----LQGTKGENSLSSTGTFLVDNSS 253
K +V IP G+RHI++ + K P + ++ + + KG+ + S T T +
Sbjct: 734 K----LVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAM----G 785
Query: 254 VDFQKFPD--KEILRMAGPLTADFIV----KIRNSGSADSTVQFIFYQPII--------- 298
++++ + KE L+ +GPL + + +++ ++ ++
Sbjct: 786 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 845
Query: 299 ------HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQ 352
+ W + PCS CGGG Q T C R + +V C + +PKP +
Sbjct: 846 LEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDH---KKRPKPIRR 902
Query: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GIQSRAVSCVEEDIQGH 411
CN PC P W W ACS SCG G+Q+R + C+ +
Sbjct: 903 RCNQHPCSQ----------------PVWVTEEWGACSRSCGKLGVQTRGIQCL-LPLSNG 945
Query: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
V K + +PC CP +W WS C+ TCG+G++ R V+C +
Sbjct: 946 THKVMPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC--RTNAN 1003
Query: 471 TGGCSPKTKPHIKEECIVP 489
+ G +P + C +P
Sbjct: 1004 SLGHCEGDRPDTVQVCSLP 1022
Score = 114 bits (284), Expect = 1e-24
Identities = 56/177 (31%), Positives = 88/177 (49%), Gaps = 6/177 (3%)
Query: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
+ Y+W + + CS++CGGG+Q C ++ + +LC +RP + + CN PC
Sbjct: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
Query: 667 PAR-WEIGKWSPCSLTCG-VGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN 724
W +W CS +CG +G+QTR + C LS ++ ++ + C +P + C
Sbjct: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHK--VMPAKACAGDRPEARRPCL 967
Query: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE--LPETFCSASKPAC 779
R CP W W CS TCG G+Q+R+V+C+ E P+T S PAC
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPAC 1024
Score = 110 bits (275), Expect = 1e-23
Identities = 52/152 (34%), Positives = 81/152 (53%), Gaps = 11/152 (7%)
Query: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELC---RQPKPSTVQACNRF 726
W + W+PCS CG G+Q C R + ++ LC ++PKP + CN+
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGC-----RRRRDHHMVQRHLCDHKKRPKPIR-RRCNQH 907
Query: 727 NCP-PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
C P W +W CSR+CG GVQ R + C +++G+ +P C+ +P ++ C
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
Query: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
+ CP++W L W++CS +CGEG Q R +CR
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR 999
Score = 92.4 bits (228), Expect = 3e-18
Identities = 58/193 (30%), Positives = 87/193 (45%), Gaps = 18/193 (9%)
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W + SW+ C+++CGGG+Q + C++ + + V +C + + CNQ C
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHM---VQRHLCDHKKRPKPIRRRCNQHPCS 910
Query: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFC----QTRDGITLPSEQCSALPRPVSTQNCW 1662
+ W WG C+ C L VQ R + C +P++ C+ RP + + C
Sbjct: 911 QPVWVTEEWGACSRSC--GKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCL 967
Query: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
C WR+ W+ C+ATCG G Q R+V C RTN H C G RP Q C++
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGE-GIQQRQVVC---RTNANSLGH-CE-GDRPDTVQVCSL 1021
Query: 1723 TPCENMECRDTTR 1735
C T R
Sbjct: 1022 PACGGNHQNSTVR 1034
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/204 (29%), Positives = 80/204 (39%), Gaps = 40/204 (19%)
Query: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
++W+ C+ CG G Q C+ L D + PKP +R C PCS +
Sbjct: 857 KSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHL-CDHKKRPKPIRRR-CNQHPCSQPV- 913
Query: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCL---NKQTREPAE 644
W E + CS SCG GVQ + CL + T +
Sbjct: 914 ----------------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMP 951
Query: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
C R P+ + C PCPA+W +G WS CS TCG G+Q R V C T
Sbjct: 952 AKACAGDR--PEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC---------RT 1000
Query: 705 VILADELCRQPKPSTVQACNRFNC 728
+ C +P TVQ C+ C
Sbjct: 1001 NANSLGHCEGDRPDTVQVCSLPAC 1024
Score = 77.0 bits (188), Expect = 1e-13
Identities = 70/278 (25%), Positives = 102/278 (36%), Gaps = 36/278 (12%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRDCP 1546
Y W++ A CS +CG G+Q + C V C K RP CN+ C
Sbjct: 852 YEWALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS 910
Query: 1547 SR-WMVTSWSACTRSCGG-GVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
W+ W AC+RSCG GVQTR + C ++G + C RP + C +
Sbjct: 911 QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC--AGDRPEARRPCLR 968
Query: 1605 QLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
C +W +W QC+ C +Q RQV C+T E RP + Q C
Sbjct: 969 VPCPAQWRLGAWSQCSATC---GEGIQQRQVVCRTNANSLGHCEG----DRPDTVQVCSL 1021
Query: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
AC GN+ + R + T + W P+ N
Sbjct: 1022 PACG---------------GNHQNSTVRADVWELGTPEG------QWVPQSEPLHPINKI 1060
Query: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
D + +C+ + C + + CC +C K
Sbjct: 1061 SSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIK 1098
Score = 69.7 bits (169), Expect = 2e-11
Identities = 60/263 (22%), Positives = 97/263 (36%), Gaps = 80/263 (30%)
Query: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCSPKTKPH-IKEECIVPTP 491
D +W + W+PC+ CG G+++ C DH + C K +P I+ C P
Sbjct: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCN-QHP 908
Query: 492 CYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRCQ 550
C +P ++ E W AC+ +CG +G Q R ++C
Sbjct: 909 C-----------------------------SQPVWVTEEWGACSRSCGKLGVQTRGIQCL 939
Query: 551 VLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYD 610
+ LS + + +P C G +P ++R C PC +
Sbjct: 940 LPLS-NGTHKVMPAKACAGDRPEARRPCLRVPCPAQ------------------------ 974
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPAR- 669
W +++CS +CG G+Q+ V C C R P ++ C+L C
Sbjct: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNAN----SLGHCEGDR--PDTVQVCSLPACGGNH 1028
Query: 670 ---------WEI----GKWSPCS 679
WE+ G+W P S
Sbjct: 1029 QNSTVRADVWELGTPEGQWVPQS 1051
Score = 40.8 bits (94), Expect = 0.012
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 19/113 (16%)
Query: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
+G + A + C+ G C + PE +T G GG + + F CS SCGGGV
Sbjct: 528 DGTECAPGKWCFKGHCIWKSPE----QTYGQDGGWSSWTK--------FGSCSRSCGGGV 575
Query: 628 QEAVVSCLNKQTREPA-EENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCS 679
+ SC N PA LC+ P + CN + CP +E + C+
Sbjct: 576 RSRSRSCNNP---SPAYGGRLCL---GPMFEYQVCNSEECPGTYEDFRAQQCA 622
Score = 39.7 bits (91), Expect = 0.026
Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 2/75 (2%)
Query: 1652 LPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
LP S E + W + W C+ CG G Q + C R + V HLC
Sbjct: 836 LPLIGSNNVLLEEMDTYEWALKSWAPCSKACGG-GIQFTKYGCRRRRDHHMVQRHLCDHK 894
Query: 1712 PRPAN-WQRCNITPC 1725
RP +RCN PC
Sbjct: 895 KRPKPIRRRCNQHPC 909
Score = 37.0 bits (84), Expect = 0.17
Identities = 53/227 (23%), Positives = 77/227 (33%), Gaps = 56/227 (24%)
Query: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEE---------NLCVTSRRPPQL 657
EL Y +C G G Q +CL +T EP ++ C T + PP
Sbjct: 473 ELPGINYSMDEQCRFDFGSGYQ----TCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLD 528
Query: 658 LKSCNLDPCPARW----------------EIGKWSP------CSLTCGVGLQTRDVFCSH 695
C P +W + G WS CS +CG G+++R C+
Sbjct: 529 GTEC----APGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCN- 583
Query: 696 LLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
N + LC P Q CN CP + + Q C+ KR
Sbjct: 584 ------NPSPAYGGRLCLGPM-FEYQVCNSEECPGTYEDFRAQQCA--------KRNSYY 628
Query: 756 KQRMADGSFLEL-PETFCSASKPACQQACKKDDCPSEWLLSDWTECS 801
+ A S++ P+ + CQ A D ++ D T CS
Sbjct: 629 VHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS 675
Score = 33.5 bits (75), Expect = 1.9
Identities = 29/108 (26%), Positives = 43/108 (39%), Gaps = 10/108 (9%)
Query: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCP----PLPFSSSIRPCML 846
EW L W CS +CG G Q CR+ +V LC P P R C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR---RRCNQ 906
Query: 847 ATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTA 894
C++P + + + K+ +QTR + L + G ++P A
Sbjct: 907 HPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKA 954
Score = 32.0 bits (71), Expect = 5.5
Identities = 13/26 (50%), Positives = 19/26 (73%), Gaps = 2/26 (7%)
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTC 1572
S W T + +C+RSCGGGV++R +C
Sbjct: 559 SSW--TKFGSCSRSCGGGVRSRSRSC 582
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 202 bits (513), Expect = 3e-51
Identities = 134/442 (30%), Positives = 197/442 (44%), Gaps = 73/442 (16%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
G W WGPW +CSRTCGGG Y++R C + K CEG+ +RYR+C+ DCP G
Sbjct: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGK 619
Query: 88 -FRAQQCSAHNDVKH----HGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
FR +QC AHN+ G EW+P P + C L CQAKG L PKV+D
Sbjct: 620 TFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVD 679
Query: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
GT C +S +C+ G C GCD + S K D CGVC G+GSTC+ + G S SA
Sbjct: 680 GTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISG---SVTSAKP 736
Query: 201 SDDTVVAIPYGSRHIRLVLKGP-----DHLYLETKTLQGT---KGENSLSSTGTFLVDNS 252
++ IP G+ +I + + + +L K GT G+ +LS+ ++
Sbjct: 737 GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKG 796
Query: 253 SVDFQKFPDK--EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQ----------PIIH 299
V E +R PL +++ G+A +++ ++ P
Sbjct: 797 VVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFS 856
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
W ++ CS +C G+Q EC D+
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQ----------------------------- 887
Query: 360 PASDGYKQIMPYDLY----HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
PAS+ K++ P HP P+W+ W++CS +CG G + R++ C+ D G V S
Sbjct: 888 PASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHD--GGVLSH 945
Query: 416 EEWKCMYTPKMPIAQPCNIFDC 437
E + PK I C + +C
Sbjct: 946 ESCDPLKKPKHFI-DFCTMAEC 966
Score = 71.2 bits (173), Expect = 8e-12
Identities = 40/110 (36%), Positives = 50/110 (45%), Gaps = 9/110 (8%)
Query: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
W W CS SC G Q R V C DI G S +C K +PC CP+
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVEC--RDINGQPAS----ECAKEVKPASTRPCADHPCPQ 911
Query: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKP-HIKEEC 486
W EWS C+ TCG+G + R + C+ H G + C P KP H + C
Sbjct: 912 WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFC 961
Score = 63.5 bits (153), Expect = 2e-09
Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 8/97 (8%)
Query: 659 KSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPS 718
+S N P + W I +W CS +C +G Q R V C R++N A E ++ KP+
Sbjct: 847 ESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC-----RDINGQP--ASECAKEVKPA 899
Query: 719 TVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
+ + C CP W +W CS+TCG G +KR + C
Sbjct: 900 STRPCADHPCPQ-WQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/94 (35%), Positives = 47/94 (50%), Gaps = 11/94 (11%)
Query: 726 FNCPP---AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQ 781
FN P AW +W CS++C G Q+R V C+ P + C+ KPA +
Sbjct: 849 FNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ------PASECAKEVKPASTR 902
Query: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
C CP +W L +W+ CS +CG+G + RS C
Sbjct: 903 PCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 59.7 bits (143), Expect = 2e-08
Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 10/109 (9%)
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
S W++ W C++SC G Q R V C+ + S C + K P T+ C
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE------CAKEVK-PASTRPCADHP 908
Query: 1607 CVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRP 1655
C +W W C+ C + R + C + DG L E C L +P
Sbjct: 909 CPQWQLGEWSSCSKTC---GKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 57.8 bits (138), Expect = 9e-08
Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSC--LNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
W E + +CS+SC G Q +V C +N Q + + S RP C PCP
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRP------CADHPCP- 910
Query: 669 RWEIGKWSPCSLTCGVGLQTRDVFC 693
+W++G+WS CS TCG G + R + C
Sbjct: 911 QWQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 56.6 bits (135), Expect = 2e-07
Identities = 27/86 (31%), Positives = 45/86 (52%), Gaps = 7/86 (8%)
Query: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVH 1669
W WG+C+ C L Q R V C+ +G P+ +C+ +P ST+ C C
Sbjct: 858 WVIEEWGECSKSC---ELGWQRRLVECRDING--QPASECAKEVKPASTRPCADHPCP-Q 911
Query: 1670 WRVSLWTLCTATCGNYGFQSRRVECV 1695
W++ W+ C+ TCG G++ R ++C+
Sbjct: 912 WQLGEWSSCSKTCGK-GYKKRSLKCL 936
Score = 51.6 bits (122), Expect = 7e-06
Identities = 34/149 (22%), Positives = 60/149 (40%), Gaps = 34/149 (22%)
Query: 519 AVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRA 577
A+ +++ E W C+ +C +G Q R+V C + + P EC + KPAS R
Sbjct: 851 AIPTFSAWVIEEWGECSKSCELGWQRRLVEC-------RDINGQPASECAKEVKPASTRP 903
Query: 578 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK 637
C PC W+ ++ CS++CG G ++ + CL+
Sbjct: 904 CADHPCP-------------------------QWQLGEWSSCSKTCGKGYKKRSLKCLSH 938
Query: 638 QTREPAEENLCVTSRRPPQLLKSCNLDPC 666
+ E+ C ++P + C + C
Sbjct: 939 DGGVLSHES-CDPLKKPKHFIDFCTMAEC 966
Score = 38.9 bits (89), Expect = 0.045
Identities = 49/227 (21%), Positives = 76/227 (33%), Gaps = 53/227 (23%)
Query: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPV 501
+Q WSPC+ Y + +D+ EC++ KP+ + +
Sbjct: 440 SQPWSPCSA-------YMITSFLDNG---------------HGECLMD----KPQNPIQL 473
Query: 502 EAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVAD 561
LP + E+ P+A S C+ GT ++ CQ
Sbjct: 474 PGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTK--------- 524
Query: 562 LPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEG-FTKCS 620
+G + C G C + + + D F G W G + CS
Sbjct: 525 -HFPWADGTSCGEGKWCINGKC---VNKTDRKHFDTPFHG--------SWGMWGPWGDCS 572
Query: 621 ESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
+CGGGVQ + C N P +N +SCNL+ CP
Sbjct: 573 RTCGGGVQYTMRECDN-----PVPKNGGKYCEGKRVRYRSCNLEDCP 614
Score = 35.0 bits (79), Expect = 0.65
Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 8/58 (13%)
Query: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCP 789
W P W CSRTCGGGVQ R D + +C K ++C +DCP
Sbjct: 565 WGP--WGDCSRTCGGGVQ-----YTMRECDNPVPKNGGKYCE-GKRVRYRSCNLEDCP 614
Score = 33.9 bits (76), Expect = 1.4
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 6/60 (10%)
Query: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
S W++ +W ECS SC G Q R CR + S C +S RPC C
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE------CAKEVKPASTRPCADHPC 909
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 193 bits (491), Expect = 1e-48
Identities = 144/484 (29%), Positives = 208/484 (42%), Gaps = 73/484 (15%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W W P+ CSRTCGGG + R+C + K CEG ++YR+C+ CP A
Sbjct: 516 DGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSAS 575
Query: 87 --DFRAQQCSAHNDVKHHGQ----FYEWLPVSN--DPDNPCSLKCQAKGTTLVVELAPKV 138
FR +QC A N H W+P + P + C L C+A GT LAPKV
Sbjct: 576 GKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKV 635
Query: 139 LDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
+DGT C +S +C+ G C GCD LGS + D CGVC GD +C+ V G + +
Sbjct: 636 VDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHG 695
Query: 199 TKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQK 258
+ VVAIP G+ I + +G L + L + G F+V S+V+
Sbjct: 696 Y---NFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVV--SAVERDL 750
Query: 259 FPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQ 318
+LR +G +G+A ++Q +PI+ +
Sbjct: 751 VVKGSLLRYSG------------TGTAVESLQAS--RPIL-------------------E 777
Query: 319 LTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM--------P 370
+ E + +Y Y P+ +P+ DP S + ++ P
Sbjct: 778 PLTVEVLSVGKMTPPRVRYSFYLPK--EPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQP 835
Query: 371 YDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQ 430
D P RW A W CS+SCG G+Q RAV C Q V + C + Q
Sbjct: 836 DD--RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-----CDAAHRPVETQ 888
Query: 431 PCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEECIV 488
C CP W WSPC+ +CG+G + R + C+ H G + C+ KP + C++
Sbjct: 889 ACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVL 947
Query: 489 PTPC 492
PC
Sbjct: 948 -RPC 950
Score = 72.0 bits (175), Expect = 5e-12
Identities = 41/121 (33%), Positives = 57/121 (47%), Gaps = 10/121 (8%)
Query: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
P+RW+ SW C+ SCG G+Q R V C+ ++G T + D A RPV+TQAC +
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCR--GSAGQRTVPACD----AAHRPVETQACGEP 893
Query: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
C W S+W C+ C Q R + C G L +QC+ +P C
Sbjct: 894 -CPTWELSAWSPCSKSC---GRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRP 949
Query: 1666 C 1666
C
Sbjct: 950 C 950
Score = 70.1 bits (170), Expect = 2e-11
Identities = 39/92 (42%), Positives = 46/92 (50%), Gaps = 8/92 (8%)
Query: 664 DPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQAC 723
D PARW G W PCS +CG GLQ R V C + TV D R P QAC
Sbjct: 837 DRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQ---RTVPACDAAHR---PVETQAC 890
Query: 724 NRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
C P W + W PCS++CG G Q+R + C
Sbjct: 891 GE-PC-PTWELSAWSPCSKSCGRGFQRRSLKC 920
Score = 68.9 bits (167), Expect = 4e-11
Identities = 40/89 (44%), Positives = 49/89 (55%), Gaps = 9/89 (10%)
Query: 729 PPA-WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQACKKD 786
PPA W W PCS +CG G+QKR V C+ GS + C A+ +P QAC +
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCR-----GSAGQRTVPACDAAHRPVETQAC-GE 892
Query: 787 DCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
CP+ W LS W+ CS SCG G Q RS C
Sbjct: 893 PCPT-WELSAWSPCSKSCGRGFQRRSLKC 920
Score = 63.5 bits (153), Expect = 2e-09
Identities = 40/117 (34%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI-TLPSEQCSALPRPVSTQNCWSEACSV 1668
W SWG C+ C +Q R V C+ G T+P+ C A RPV TQ C E C
Sbjct: 843 WVAGSWGPCSASCGS---GLQKRAVDCRGSAGQRTVPA--CDAAHRPVETQAC-GEPCPT 896
Query: 1669 HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
W +S W+ C+ +CG GFQ R ++CV + + C+ +P C + PC
Sbjct: 897 -WELSAWSPCSKSCGR-GFQRRSLKCV-GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 51.6 bits (122), Expect = 7e-06
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 4/82 (4%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W CSASCG+ G+Q+ + C ++ + C RP V+ AC CP+ W
Sbjct: 843 WVAGSWGPCSASCGS-GLQKRAVDCRGSAGQRTVPACDAAHRP-VETQACG-EPCPT-WE 898
Query: 1551 VTSWSACTRSCGGGVQTRRVTC 1572
+++WS C++SCG G Q R + C
Sbjct: 899 LSAWSPCSKSCGRGFQRRSLKC 920
Score = 50.1 bits (118), Expect = 2e-05
Identities = 48/196 (24%), Positives = 68/196 (34%), Gaps = 42/196 (21%)
Query: 478 TKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEA------W 531
T P ++ +P + K P + + P L V E+P P A W
Sbjct: 790 TPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQV-EQPDDRPPARWVAGSW 848
Query: 532 SACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGP-KPASQRACYAGPCSGEIPEF 590
C+ +CG G Q R V C+ S + C+ +P +AC PC
Sbjct: 849 GPCSASCGSGLQKRAVDCR------GSAGQRTVPACDAAHRPVETQAC-GEPCP------ 895
Query: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVT 650
WE ++ CS+SCG G Q + C+ R A +
Sbjct: 896 -------------------TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQ--CN 934
Query: 651 SRRPPQLLKSCNLDPC 666
R PQ L C L PC
Sbjct: 935 LHRKPQELDFCVLRPC 950
Score = 38.5 bits (88), Expect = 0.058
Identities = 28/101 (27%), Positives = 39/101 (38%), Gaps = 17/101 (16%)
Query: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
+G + C G C E N DG + +++ + CS +CGGGV
Sbjct: 489 DGTSCGEGKLCLKGACV-ERHNLNKHRVDGSWA-----------KWDPYGPCSRTCGGGV 536
Query: 628 QEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
Q A C N P N +SCNL+PCP+
Sbjct: 537 QLARRQCTN-----PTPANGGKYCEGVRVKYRSCNLEPCPS 572
Score = 37.7 bits (86), Expect = 0.100
Identities = 14/31 (45%), Positives = 17/31 (54%)
Query: 786 DDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
D P+ W+ W CS SCG G Q R+ CR
Sbjct: 837 DRPPARWVAGSWGPCSASCGSGLQKRAVDCR 867
Score = 33.1 bits (74), Expect = 2.5
Identities = 23/71 (32%), Positives = 32/71 (45%), Gaps = 13/71 (18%)
Query: 724 NRFNCPPAWYPAQWQP---CSRTCGGGVQKREVLC-KQRMADGSFLELPETFCSASKPAC 779
N+ +W A+W P CSRTCGGGVQ C A+G +C +
Sbjct: 511 NKHRVDGSW--AKWDPYGPCSRTCGGGVQLARRQCTNPTPANGG------KYCEGVR-VK 561
Query: 780 QQACKKDDCPS 790
++C + CPS
Sbjct: 562 YRSCNLEPCPS 572
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 179 bits (455), Expect = 2e-44
Identities = 118/437 (27%), Positives = 187/437 (42%), Gaps = 91/437 (20%)
Query: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
H W++ CS TCG G Q C ++ + YC ++KP P+ + CN+ P
Sbjct: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYC---DSSMKPTPEEEPCNIFP 675
Query: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
CPA W+ W+ CS +CG G+Q R V C + +T V+ +
Sbjct: 676 CPAF-----------------WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLT-VQPY 717
Query: 419 KCMYTPKMPIAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCS 475
+C + K C + C +W + +W+ C+V CG G R R V C+ + G + C+
Sbjct: 718 RCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECN 777
Query: 476 PKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACT 535
K +P+ E C + PC K W F+ E C+
Sbjct: 778 MKLRPNDIENCDM-GPCAK-----------SW------------------FLTEWSERCS 807
Query: 536 VTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDET 595
CG G + R V C + V+ LP++ C +PA C GPC+G++
Sbjct: 808 AECGAGVRTRSVVC-----MTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKV-------- 854
Query: 596 DGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCL--NKQTREPAEENLCVTSRR 653
+W +++CS CG G Q+ V C+ N T E + + C +
Sbjct: 855 --------------EWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK 900
Query: 654 PPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR 713
PP +SC+L PC A+W +WS CS +C G + R+V C +++ + L++
Sbjct: 901 PPS-QQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRC-------LSDDMTLSNLCDP 952
Query: 714 QPKPSTVQACNRFNCPP 730
Q KP ++CN +C P
Sbjct: 953 QLKPEERESCNPQDCVP 969
Score = 145 bits (366), Expect = 3e-34
Identities = 117/417 (28%), Positives = 164/417 (39%), Gaps = 81/417 (19%)
Query: 427 PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG----CSPKTKPHI 482
P QP W + C+ TCG+G +Y + C+ HR H C KP
Sbjct: 608 PAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCV-HRSTHEEAPESYCDSSMKPTP 666
Query: 483 KEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGT 542
+EE PC P F E WS C+ TCG+G
Sbjct: 667 EEEPCNIFPC-------------PAFWDIGE-----------------WSECSKTCGLGM 696
Query: 543 QVRIVRC-QVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGG 601
Q R V C QV + S +V E KP + C CS
Sbjct: 697 QHRQVLCRQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS----------------- 737
Query: 602 LQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSC 661
++ DW T CS CG G + V C++ + ++ C RP + ++C
Sbjct: 738 --EWQIRTDW-----TSCSVPCGVGQRTRDVKCVSN-IGDVVDDEECNMKLRPNDI-ENC 788
Query: 662 NLDPCPARWEIGKWSP-CSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV 720
++ PC W + +WS CS CG G++TR V C N L E C +P+
Sbjct: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCM------TNHVSSLPLEGCGNNRPAEA 842
Query: 721 QACNRFNCPPA--WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKP 777
C+ C W+ W CS CG G Q+REV+C ++ AD +F L + CS KP
Sbjct: 843 TPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNAD-TFEVLDPSECSFLEKP 901
Query: 778 ACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPP 834
QQ+C C ++W ++W+ CS SC G + R C + S LC P
Sbjct: 902 PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLS------DDMTLSNLCDP 952
Score = 124 bits (310), Expect = 1e-27
Identities = 80/273 (29%), Positives = 123/273 (45%), Gaps = 26/273 (9%)
Query: 1498 TCSASCGNRGVQQPRLRCLLNSTEV-NPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSA 1556
+CS CG G + ++C+ N +V + C K+RP C+ C W +T WS
Sbjct: 747 SCSVPCGV-GQRTRDVKCVSNIGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFLTEWSE 804
Query: 1557 -CTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC---VEWAF 1612
C+ CG GV+TR V C S + + RP + C+ C VEW
Sbjct: 805 RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGN------NRPAEATPCDNGPCTGKVEWFA 858
Query: 1613 SSWGQCNGPCIGPHLAVQHRQVFCQTRDGIT---LPSEQCSALPRPVSTQNCWSEACSVH 1669
SW QC+ C Q R+V C ++ T L +CS L +P S Q+C + C
Sbjct: 859 GSWSQCSIECGS---GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
Query: 1670 WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC---E 1726
W + W++C+ +C GF+ R V C+ ++ +LC +P + CN C
Sbjct: 916 WFSTEWSMCSKSCQG-GFRVREVRCL---SDDMTLSNLCDPQLKPEERESCNPQDCVPEV 971
Query: 1727 NMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
+ C+D C V Q +LC + +K+ CC +C
Sbjct: 972 DENCKDKYYNCNVVVQARLCVYNYYKTACCASC 1004
Score = 121 bits (304), Expect = 5e-27
Identities = 67/188 (35%), Positives = 96/188 (51%), Gaps = 2/188 (1%)
Query: 48 TCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYE 107
T G S+S ++ SC G +Y+ C+ CP + R QC+++N+ G+FYE
Sbjct: 273 THGATQSFSQPARSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYE 332
Query: 108 WLPVSNDPDN-PCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQL 166
W P + N C L CQA G V A KV+DGT C +C+SG C+ +GCD L
Sbjct: 333 WEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYL 392
Query: 167 GSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLY 226
GS D CGVC GD + C++V G +K L++ VV IP G+ I + + Y
Sbjct: 393 GSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSL-GYHRVVEIPEGATKINITEMYKSNNY 451
Query: 227 LETKTLQG 234
L ++ G
Sbjct: 452 LALRSRSG 459
Score = 120 bits (302), Expect = 9e-27
Identities = 77/248 (31%), Positives = 123/248 (49%), Gaps = 18/248 (7%)
Query: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNST--EVNPAHCAGKVRPAVQPIACNRRD 1544
+D+ W CS +CG +G Q P RC+ ST E ++C ++P + CN
Sbjct: 617 RDHNWKQLGTTECSTTCG-KGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFP 675
Query: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
CP+ W + WS C+++CG G+Q R+V C+++ A+ S V C Q ++P T C
Sbjct: 676 CPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANR-SLTVQPYRC-QHLEKPETTSTCQL 733
Query: 1605 QLCVEWAF-SSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
++C EW + W C+ PC + + R V C + G + E+C+ RP +NC
Sbjct: 734 KICSEWQIRTDWTSCSVPC---GVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDM 790
Query: 1664 EACSVHWRVSLWT-LCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
C+ W ++ W+ C+A CG G ++R V C+ + ++P C RPA
Sbjct: 791 GPCAKSWFLTEWSERCSAECG-AGVRTRSVVCMTNHVS-SLPLEGCG-NNRPA-----EA 842
Query: 1723 TPCENMEC 1730
TPC+N C
Sbjct: 843 TPCDNGPC 850
Score = 82.4 bits (202), Expect = 4e-15
Identities = 53/193 (27%), Positives = 77/193 (39%), Gaps = 24/193 (12%)
Query: 296 PIIHRWRETDFFP-CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
P W T++ CSA CG G + S C + + + + P P C
Sbjct: 792 PCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATP------C 845
Query: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
+ PC W A W+ CS CG G Q R V CV ++
Sbjct: 846 DNGPCTGK---------------VEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEV- 889
Query: 415 VEEWKCMYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG 473
++ +C + K P Q C++ C KW + EWS C+ +C G R R V C+ +
Sbjct: 890 LDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNL 949
Query: 474 CSPKTKPHIKEEC 486
C P+ KP +E C
Sbjct: 950 CDPQLKPEERESC 962
Score = 64.3 bits (155), Expect = 1e-09
Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 13/122 (10%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTE----VNPAHCAGKVRPAVQPIACNRRDCP 1546
W + CS CG+ G QQ + C+ + + ++P+ C+ +P Q +C+ + C
Sbjct: 856 WFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQ-SCHLKPCG 913
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
++W T WS C++SC GG + R V C +S ++ +P + ++CN Q
Sbjct: 914 AKWFSTEWSMCSKSCQGGFRVREVRC-------LSDDMTLSNLCDPQLKPEERESCNPQD 966
Query: 1607 CV 1608
CV
Sbjct: 967 CV 968
Score = 47.4 bits (111), Expect = 1e-04
Identities = 17/28 (60%), Positives = 19/28 (67%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCL 61
G+W AWGPWS CSR+C GG R CL
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCL 81
Score = 35.0 bits (79), Expect = 0.65
Identities = 17/59 (28%), Positives = 27/59 (45%), Gaps = 1/59 (1%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCS 94
WD G WSECS+TCG G + C + ++ C +++ P + + CS
Sbjct: 680 WDI-GEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
Score = 32.3 bits (72), Expect = 4.2
Identities = 19/53 (35%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPE 84
RD W G +ECS TCG G+ Y + RC+ + E Y S P E
Sbjct: 617 RDHNWKQLGT-TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEE 668
Score = 31.6 bits (70), Expect = 7.1
Identities = 10/21 (47%), Positives = 14/21 (66%)
Query: 384 PWTACSSSCGGGIQSRAVSCV 404
PW+ACS SC GG+ + C+
Sbjct: 61 PWSACSRSCSGGVMEQTRPCL 81
Score = 31.2 bits (69), Expect = 9.3
Identities = 30/118 (25%), Positives = 44/118 (37%), Gaps = 26/118 (22%)
Query: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDV 99
G WS+CS CG G C+ + + CS ++ PP + C A
Sbjct: 859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA---- 914
Query: 100 KHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLC 157
+W + + CS CQ G V E+ RC ++ DM +S LC
Sbjct: 915 -------KWF---STEWSMCSKSCQ--GGFRVREV--------RCLSD--DMTLSNLC 950
Score = 31.2 bits (69), Expect = 9.3
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 7/53 (13%)
Query: 42 WSECSRTCGGGASYSLRRCLS-----SKSCEG--RNIRYRTCSNVDCPPEAGD 87
WS CS++C GG RCLS S C+ + +C+ DC PE +
Sbjct: 921 WSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVDE 973
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 177 bits (449), Expect = 8e-44
Identities = 119/373 (31%), Positives = 167/373 (44%), Gaps = 55/373 (14%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
DG W WGPW ECSRTCGGG +S R C + C GR +Y++C +CPP+
Sbjct: 526 DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
Query: 87 DFRAQQC---SAHNDVKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
FR QQC +A+N G +W+P P + C L C+A+G + KV+DG
Sbjct: 586 SFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
Query: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
T C E+L +C+ G C GCDH + S K D CGVC G G++CR V G S
Sbjct: 646 TLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSG---SLTPTNYG 702
Query: 202 DDTVVAIPYGSRHI---------------RLVLKGPDHLYLETKTLQGTKGENSLSSTGT 246
+ +V IP G+ +I L LK D YL L + E + GT
Sbjct: 703 YNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGT 762
Query: 247 FLVDNSSV-------DFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI------- 292
L + S+ F+ P+ +++ F K++ + + V F
Sbjct: 763 ILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKER 822
Query: 293 ----FYQPIIH-RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKP 347
QP++H +W D+ CS+TCG G+Q + EC D S + A PE+ KP
Sbjct: 823 ATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPEDAKP 881
Query: 348 KPKLQECNLDPCP 360
C CP
Sbjct: 882 ------CESQLCP 888
Score = 44.7 bits (104), Expect = 8e-04
Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 11/55 (20%)
Query: 790 SEWLLSDWTECSTSCGEGTQTR-----------SAICRKMLKTGLSTVVNSTLCP 833
++W+L DW+ECS++CG G Q R SA C K LK + S LCP
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 42.7 bits (99), Expect = 0.003
Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 7/61 (11%)
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
++W++ WS C+ +CG G Q R V C+ SG ++ N A +P D + C QL
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECR--DPSGQASATCNK-----ALKPEDAKPCESQL 886
Query: 1607 C 1607
C
Sbjct: 887 C 887
Score = 42.4 bits (98), Expect = 0.004
Identities = 17/48 (35%), Positives = 25/48 (52%)
Query: 439 KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
+W+ +WS C+ TCG G + R V C D G + C+ KP + C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPC 882
Score = 39.7 bits (91), Expect = 0.026
Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 9/63 (14%)
Query: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP-KPSTVQACNRF 726
A+W +G WS CS TCG G Q R V C + A C + KP + C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--------ASATCNKALKPEDAKPCESQ 885
Query: 727 NCP 729
CP
Sbjct: 886 LCP 888
Score = 39.3 bits (90), Expect = 0.034
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 6/60 (10%)
Query: 379 RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
+W W+ CSS+CG G Q R V C + Q T C K A+PC CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT------CNKALKPEDAKPCESQLCP 888
Score = 39.3 bits (90), Expect = 0.034
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 5/58 (8%)
Query: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCP 789
W W CS TCG G Q+R V C+ S T A KP + C+ CP
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQAS-----ATCNKALKPEDAKPCESQLCP 888
Score = 37.4 bits (85), Expect = 0.13
Identities = 27/91 (29%), Positives = 36/91 (39%), Gaps = 16/91 (17%)
Query: 702 NETVILADELCRQPKPSTVQACNRFNCPPAWYP-AQWQPCSRTCGGGVQKREVLCKQRMA 760
+E L +E +PKP W P W CSRTCGGGVQ CK
Sbjct: 508 SEGSCLPEEEVERPKPVA---------DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEP 558
Query: 761 DGSFLELPETFCSASKPACQQACKKDDCPSE 791
+C + A Q+C ++CP +
Sbjct: 559 QNG-----GRYC-LGRRAKYQSCHTEECPPD 583
Score = 34.3 bits (77), Expect = 1.1
Identities = 22/84 (26%), Positives = 30/84 (35%), Gaps = 5/84 (5%)
Query: 1583 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI 1642
P D Q +K T L +W W +C+ C Q R V C RD
Sbjct: 809 PNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTC---GAGWQRRTVEC--RDPS 863
Query: 1643 TLPSEQCSALPRPVSTQNCWSEAC 1666
S C+ +P + C S+ C
Sbjct: 864 GQASATCNKALKPEDAKPCESQLC 887
Score = 32.3 bits (72), Expect = 4.2
Identities = 21/74 (28%), Positives = 31/74 (41%), Gaps = 9/74 (12%)
Query: 1657 STQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPAN 1716
+T N W + W+ C++TCG G+Q R VEC R C+ +P
Sbjct: 823 ATTNIIQPLLHAQWVLGDWSECSSTCG-AGWQRRTVEC---RDPSGQASATCNKALKPE- 877
Query: 1717 WQRCNITPCENMEC 1730
+ PCE+ C
Sbjct: 878 ----DAKPCESQLC 887
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 167 bits (422), Expect = 1e-40
Identities = 145/546 (26%), Positives = 218/546 (39%), Gaps = 94/546 (17%)
Query: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
Query: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
G++ + + + P + E L GP T I + N G +F
Sbjct: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
Query: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
YQ +I + + N PE ++ +P L
Sbjct: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
Query: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
Query: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
Query: 462 LCIDHRGMHTGGCSPKTKPHIKEECIVPTPC-YKPKEKLPVEAKLPWFKQAQELEEGAAV 520
C G GG S + P C + P+ + +L + E G+
Sbjct: 749 QCRQEFG--GGGSS-----------VPPERCGHLPRPNITQSCQL---RLCGHWEVGS-- 790
Query: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG--PKPASQRAC 578
WS C+V CG G + R VRC + ++ EC P+P S+ AC
Sbjct: 791 ---------PWSQCSVRCGRGQRSRQVRC-----VGNNGDEVSEQECASGPPQPPSREAC 836
Query: 579 YAGPCS 584
GPC+
Sbjct: 837 DMGPCT 842
Score = 115 bits (288), Expect = 4e-25
Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 8/190 (4%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARW 670
W+ G + CS SCG GV + C+++++ E +E C RPP + C+ PCP W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 671 EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP 730
E G+W+ CS +CG G Q R + C + + + P+P+ Q+C C
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGG--GGSSVPPERCGHLPRPNITQSCQLRLCGH 785
Query: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS--KPACQQACKKDDC 788
+ W CS CG G + R+V C D E+ E C++ +P ++AC C
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD----EVSEQECASGPPQPPSREACDMGPC 841
Query: 789 PSEWLLSDWT 798
+ W SDW+
Sbjct: 842 TTAWFHSDWS 851
Score = 105 bits (262), Expect = 4e-22
Identities = 65/192 (33%), Positives = 95/192 (49%), Gaps = 11/192 (5%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNST--EVNPAHCAGKVRPAVQPIACNRRDCP 1546
YW V A CSASCG +GV +P C+ + E++ CA RP P C+ CP
Sbjct: 667 YWKRVGHSA-CSASCG-KGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP 724
Query: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
W W++C+RSCG G Q R++ C++ + G + V + C + RP TQ+C +L
Sbjct: 725 PYWEAGEWTSCSRSCGPGTQHRQLQCRQ-EFGGGGSSVPPERCGHL-PRPNITQSCQLRL 782
Query: 1607 CVEWAFSS-WGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQC-SALPRPVSTQNCWSE 1664
C W S W QC+ C + RQV C +G + ++C S P+P S + C
Sbjct: 783 CGHWEVGSPWSQCSVRC---GRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
Query: 1665 ACSVHWRVSLWT 1676
C+ W S W+
Sbjct: 840 PCTTAWFHSDWS 851
Score = 92.8 bits (229), Expect = 3e-18
Identities = 58/182 (31%), Positives = 84/182 (46%), Gaps = 13/182 (7%)
Query: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
W SAC+ SCG GV C ++ + C A+ P + C+ C
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESG---EELDERSCAAGARPPASPEPCHGTPCP 724
Query: 1609 E-WAFSSWGQCNGPCIGPHLAVQHRQVFCQTR---DGITLPSEQCSALPRPVSTQNCWSE 1664
W W C+ C GP QHRQ+ C+ G ++P E+C LPRP TQ+C
Sbjct: 725 PYWEAGEWTSCSRSC-GP--GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR 781
Query: 1665 ACSVHWRV-SLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
C HW V S W+ C+ CG G +SR+V CV ++ + S P+P + + C++
Sbjct: 782 LCG-HWEVGSPWSQCSVRCGR-GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
Query: 1724 PC 1725
PC
Sbjct: 840 PC 841
Score = 87.4 bits (215), Expect = 1e-16
Identities = 46/148 (31%), Positives = 68/148 (45%), Gaps = 3/148 (2%)
Query: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFN 727
A W+ S CS +CG G+ C +SRE E + P++ + C+
Sbjct: 666 AYWKRVGHSACSASCGKGVWRPIFLC---ISRESGEELDERSCAAGARPPASPEPCHGTP 722
Query: 728 CPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
CPP W +W CSR+CG G Q R++ C+Q G PE +P Q+C+
Sbjct: 723 CPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRL 782
Query: 788 CPSEWLLSDWTECSTSCGEGTQTRSAIC 815
C + S W++CS CG G ++R C
Sbjct: 783 CGHWEVGSPWSQCSVRCGRGQRSRQVRC 810
Score = 73.2 bits (178), Expect = 2e-12
Identities = 61/213 (28%), Positives = 86/213 (40%), Gaps = 43/213 (20%)
Query: 532 SACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE--GPKPASQRACYAGPCSGEIPE 589
SAC+ +CG G I C +S +L C PAS C+ PC P
Sbjct: 674 SACSASCGKGVWRPIFLC----ISRESGEELDERSCAAGARPPASPEPCHGTPC----PP 725
Query: 590 FNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK----QTREPAEE 645
+ WE +T CS SCG G Q + C + + P E
Sbjct: 726 Y--------------------WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
Query: 646 NLCVTSRRPPQLLKSCNLDPCPARWEIGK-WSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
C R P + +SC L C WE+G WS CS+ CG G ++R V C E++E
Sbjct: 766 --CGHLPR-PNITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQ 821
Query: 705 VILADELCRQPKPSTVQACNRFNCPPAWYPAQW 737
+ P+P + +AC+ C AW+ + W
Sbjct: 822 ECASG----PPQPPSREACDMGPCTTAWFHSDW 850
Score = 69.7 bits (169), Expect = 2e-11
Identities = 43/120 (35%), Positives = 53/120 (44%), Gaps = 6/120 (5%)
Query: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASK--PACQQACKKDDCP 789
W CS +CG GV + LC R + EL E C+A PA + C CP
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGE---ELDERSCAAGARPPASPEPCHGTPCP 724
Query: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
W +WT CS SCG GTQ R CR+ G S+V C LP + + C L C
Sbjct: 725 PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER-CGHLPRPNITQSCQLRLC 783
Score = 66.6 bits (161), Expect = 2e-10
Identities = 60/278 (21%), Positives = 102/278 (36%), Gaps = 74/278 (26%)
Query: 424 PKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGGCSPKTKP 480
P+ P+ P W S C+ +CG+G+ + LCI + C+ +P
Sbjct: 657 PRTPLGSPAAY-----WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP 711
Query: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
E TPC P + +A E W++C+ +CG
Sbjct: 712 PASPEPCHGTPC-------------PPYWEAGE-----------------WTSCSRSCGP 741
Query: 541 GTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEIPEFNPDETDGLF 599
GTQ R ++C+ F + +P + C P+P ++C C
Sbjct: 742 GTQHRQLQCR--QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCG--------------- 784
Query: 600 GGLQDFDELYDWEY-EGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLL 658
WE +++CS CG G + V C+ E +E+ C + P
Sbjct: 785 ----------HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE-CASGPPQPPSR 833
Query: 659 KSCNLDPCPARWEIGKWS------PCSLTCGVGLQTRD 690
++C++ PC W WS P +++C +G +D
Sbjct: 834 EACDMGPCTTAWFHSDWSSKVSPEPPAISCILGNHAQD 871
Score = 50.8 bits (120), Expect = 1e-05
Identities = 34/111 (30%), Positives = 48/111 (43%), Gaps = 6/111 (5%)
Query: 1632 RQVF-CQTRD-GITLPSEQCSALPRP-VSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQ 1688
R +F C +R+ G L C+A RP S + C C +W WT C+ +CG G Q
Sbjct: 686 RPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGP-GTQ 744
Query: 1689 SRRVECVH--ARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYC 1737
R+++C +VP C PRP Q C + C + E C
Sbjct: 745 HRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQC 795
Score = 37.4 bits (85), Expect = 0.13
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 2/80 (2%)
Query: 1478 LMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNS-TEVNPAHCAGKVRPAVQ 1536
+ Q L + +W + CS CG RG + ++RC+ N+ EV+ CA
Sbjct: 774 ITQSCQLRLCGHWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
Query: 1537 PIACNRRDCPSRWMVTSWSA 1556
AC+ C + W + WS+
Sbjct: 833 REACDMGPCTTAWFHSDWSS 852
Score = 33.9 bits (76), Expect = 1.4
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
+G+W W W+ CS+ CG G R C
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 33.5 bits (75), Expect = 1.9
Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 15/88 (17%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
Query: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKC 123
H +V P + CS++C
Sbjct: 785 HWEV-------------GSPWSQCSVRC 799
Score = 33.1 bits (74), Expect = 2.5
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
G W+ PWS+CS CG G RC+ + E
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
Score = 31.6 bits (70), Expect = 7.1
Identities = 13/26 (50%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 732 WYP-AQWQPCSRTCGGGVQKREVLCK 756
W P QW CS+ CG GVQ+R C+
Sbjct: 47 WGPWVQWASCSQPCGVGVQRRSRTCQ 72
Score = 31.2 bits (69), Expect = 9.3
Identities = 11/20 (55%), Positives = 15/20 (75%)
Query: 1554 WSACTRSCGGGVQTRRVTCQ 1573
W++C++ CG GVQ R TCQ
Sbjct: 53 WASCSQPCGVGVQRRSRTCQ 72
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 159 bits (401), Expect = 3e-38
Identities = 112/348 (32%), Positives = 158/348 (45%), Gaps = 52/348 (14%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAGD 87
G W +WG W +CSR+CGGG ++ R C + + C G+ YR+CS + CPP
Sbjct: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
Query: 88 FRAQQCSAHN----DVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLDG 141
FR +QC A N D K F EW+P P + C L C+AKGT V +PKV DG
Sbjct: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
Query: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
T C S +C+ G C GCD +GS ++ D CGVC GD S+C + G + + +K
Sbjct: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKK---SKG 744
Query: 202 DDTVVAIPYGSRHIRL-VLKGPDH----LYLETKTLQG---TKGENSLSSTGTFLVDNSS 253
VV IP G+ HI++ K D YL K G G+ +S++ T + N +
Sbjct: 745 YTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGT 804
Query: 254 V----------DFQK----FPDKEILRM-------AGPLTA--DFIVKIRNSGSADSTVQ 290
V DF KEIL + PL F V +++ +S
Sbjct: 805 VMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTS 864
Query: 291 FIFYQPIIH----RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
+ H +W + CS TC G+ + +C D NR +A
Sbjct: 865 HGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQD--GNRKLA 910
Score = 40.0 bits (92), Expect = 0.020
Identities = 33/116 (28%), Positives = 41/116 (35%), Gaps = 15/116 (12%)
Query: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
EG R C G C D+T + W G +CS SCGGGV
Sbjct: 538 EGTPCGKGRICLQGKCV--------DKTKKKYYSTSSHGNWGSWGSWG--QCSRSCGGGV 587
Query: 628 QEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCG 683
Q A C N R C R + +SC+L PCP + + C G
Sbjct: 588 QFAYRHCNNPAPRN--NGRYCTGKR---AIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
Score = 37.0 bits (84), Expect = 0.17
Identities = 15/51 (29%), Positives = 23/51 (45%)
Query: 438 PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIV 488
P+W+ W C+ TC G R V C D GC +P ++C++
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLL 927
Score = 34.3 bits (77), Expect = 1.1
Identities = 12/26 (46%), Positives = 15/26 (57%)
Query: 378 PRWEATPWTACSSSCGGGIQSRAVSC 403
P+W PW ACS +C G +R V C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQC 902
Score = 33.1 bits (74), Expect = 2.5
Identities = 18/63 (28%), Positives = 26/63 (41%), Gaps = 14/63 (22%)
Query: 791 EWLLSDWTECSTSCGEGTQTRSAIC----RKMLKTGLSTVVNSTLCPPLPFSSSIRPCML 846
+W+ W CS +C G TR+ C RK+ K CP S+ + C+L
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG----------CPLSQRPSAFKQCLL 927
Query: 847 ATC 849
C
Sbjct: 928 KKC 930
Score = 33.1 bits (74), Expect = 2.5
Identities = 12/26 (46%), Positives = 16/26 (61%)
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQ 1573
+W+ W AC+R+C G TR V CQ
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQ 903
Score = 31.6 bits (70), Expect = 7.1
Identities = 11/30 (36%), Positives = 17/30 (56%)
Query: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQ 550
+ +P ++ W AC+ TC G R V+CQ
Sbjct: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQCQ 903
Score = 31.2 bits (69), Expect = 9.3
Identities = 38/180 (21%), Positives = 63/180 (35%), Gaps = 25/180 (13%)
Query: 581 GPCSGEIPE---FNPDETDG-LFGGLQDFDELYDWEYE---GFTKCSESCGGGVQEAVVS 633
G C ++P P+E G + Q + + EY G C+ V++ +
Sbjct: 469 GNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMV 528
Query: 634 CLNKQTREPAEEN-------LCVTSRRPPQLLKSCNLDPCPARW-EIGKWSPCSLTCGVG 685
CL K+ PA E +C+ + + K W G W CS +CG G
Sbjct: 529 CLTKKL--PAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGG 586
Query: 686 LQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCG 745
+Q C++ R K + ++C+ CPP + + C G
Sbjct: 587 VQFAYRHCNNPAPRNNGRYC--------TGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNG 638
Score = 31.2 bits (69), Expect = 9.3
Identities = 11/14 (78%), Positives = 12/14 (85%)
Query: 1553 SWSACTRSCGGGVQ 1566
SW C+RSCGGGVQ
Sbjct: 575 SWGQCSRSCGGGVQ 588
Score = 31.2 bits (69), Expect = 9.3
Identities = 12/27 (44%), Positives = 13/27 (48%)
Query: 730 PAWYPAQWQPCSRTCGGGVQKREVLCK 756
P W W CSRTC G R V C+
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQ 903
Score = 31.2 bits (69), Expect = 9.3
Identities = 12/25 (48%), Positives = 13/25 (52%)
Query: 669 RWEIGKWSPCSLTCGVGLQTRDVFC 693
+W G W CS TC G TR V C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQC 902
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 156 bits (394), Expect = 2e-37
Identities = 100/286 (34%), Positives = 141/286 (49%), Gaps = 26/286 (9%)
Query: 34 GLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPP-EAG 86
G W WGPW +CSRTCGGG +S R C K CEGR R+R+C+ DCP A
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSAL 580
Query: 87 DFRAQQCSAHND----VKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
FR +QC+A+N K +W+P P + C L CQA+ L P+V+D
Sbjct: 581 TFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVD 640
Query: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
GT C +S +C+ G C GCD +GS K D C VC GDGS C G ++
Sbjct: 641 GTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFR---KFRY 697
Query: 201 SDDTVVAIPYGSRHIRLVLKG-PDH--LYLETKTLQGT---KGENSLSSTGTFLVDNSSV 254
+ VV IP G+ HI + +G P H +YL K G+ GE +L + T +V +V
Sbjct: 698 GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
Query: 255 DFQ---KFPDKEILRMAGPLTADFIVKIRNSGS-ADSTVQFIFYQP 296
+ E L GPL +++ +G+ D+ +++ F+ P
Sbjct: 758 SLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
Score = 37.0 bits (84), Expect = 0.17
Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 9/68 (13%)
Query: 726 FNCPPA--WYP-AQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQA 782
FN P A W P W CSRTCGGGVQ C + + +C + ++
Sbjct: 515 FNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNG-----GKYCEGRRTRF-RS 568
Query: 783 CKKDDCPS 790
C +DCP+
Sbjct: 569 CNTEDCPT 576
Score = 32.3 bits (72), Expect = 4.2
Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 8/52 (15%)
Query: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
CS TCGGG Q +S +C R +YC + + + CN + CP
Sbjct: 532 CSRTCGGGVQFSSRDC--TRPVPRNGGKYCE------GRRTRFRSCNTEDCP 575
Score = 31.2 bits (69), Expect = 9.3
Identities = 27/103 (26%), Positives = 39/103 (37%), Gaps = 21/103 (20%)
Query: 568 EGPKPASQRACYAGPC--SGEIPEFNPDETDGLFGGLQDFDELYDWEYEG-FTKCSESCG 624
+G +AC G C ++ +FN + G W G + CS +CG
Sbjct: 491 DGTPCGPAQACMGGRCLHMDQLQDFNIPQAGG-------------WGPWGPWGDCSRTCG 537
Query: 625 GGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
GGVQ + C R + C R +SCN + CP
Sbjct: 538 GGVQFSSRDCTRPVPRNGGK--YCEGRR---TRFRSCNTEDCP 575
Score = 31.2 bits (69), Expect = 9.3
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
PW CS +CGGG+Q + C + E + + + CN DCP
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF-------RSCNTEDCP 575
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 154 bits (389), Expect = 7e-37
Identities = 102/386 (26%), Positives = 158/386 (40%), Gaps = 75/386 (19%)
Query: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG--CSPKTKPHIKEECIVPTPCY 493
D +W PC+ TC G+ +C+ + G+ C T+P E C
Sbjct: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
Query: 494 KPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLL 553
+P + +WS C+ TCG G Q R+VRC +L
Sbjct: 623 -----------------------------QPRWETSSWSECSRTCGEGYQFRVVRCWKML 653
Query: 554 S--FSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDW 611
S F SV + E +P ++ C C + W
Sbjct: 654 SPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ------------------------W 689
Query: 612 EYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWE 671
E +++C+ CG + +VV+ + R +E LC + RP K+C PC +W
Sbjct: 690 EMSEWSECTAKCG---ERSVVT---RDIRCSEDEKLCDPNTRPVGE-KNCTGPPCDRQWT 742
Query: 672 IGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACNRFNCPP 730
+ W PCS +CG G R V+C + ++ ++ + C+ + KP + C NCP
Sbjct: 743 VSDWGPCSGSCGQGRTIRHVYC------KTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
Query: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDCP 789
W W+ C+ TCG GV+KR VLC + +A+G C A KP + C + C
Sbjct: 797 HWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC- 854
Query: 790 SEWLLSDWTECSTSCGEGTQTRSAIC 815
+W S W+EC+ +CG G + R C
Sbjct: 855 FKWYTSPWSECTKTCGVGVRMRDVKC 880
Score = 132 bits (332), Expect = 3e-30
Identities = 88/287 (30%), Positives = 131/287 (45%), Gaps = 29/287 (10%)
Query: 36 WDAWGPWSECSRTCGGGASYSLRRCLS----------SKSCEGRNIRYRTCSNVDCPPEA 85
W W W+ CSR+CGGG + R CL +++C G + RY+ C +CPP+
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 86 GDFRAQQCSAHNDVKHHGQFYEWLPVSNDP-----DNPCSLKCQAKGTTLVVELAPKVLD 140
FR +QC + N ++G+ ++W P+ D PC L C +L D
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQR--QLMVPARD 167
Query: 141 GTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
GT C T+ +C+SG C+ +GCD L ST D CG+C GDGS+C V G Y+ +A
Sbjct: 168 GTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG-NAH 226
Query: 200 KSDDTVVAIPYGSRHIRLV--LKGPDHLYLETKT-LQGTKGENSLSSTGTFLVDNSSVDF 256
V IP G+R I++V K D L L + G + S F + + V +
Sbjct: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKNFNIAGTVVKY 286
Query: 257 QKFPDK-----EILRMAGPLTADFIVKI--RNSGSADSTVQFIFYQP 296
++ D E + GP V + +N S T ++ QP
Sbjct: 287 RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
Score = 128 bits (321), Expect = 6e-29
Identities = 83/278 (29%), Positives = 119/278 (42%), Gaps = 36/278 (12%)
Query: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Y W + CSA+C GV C+ + EV+ ++C RP C R+C
Sbjct: 566 YRWKLSSHEPCSATC-TTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
Query: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQV-AKRPVDTQACNQQL 1606
RW +SWS C+R+CG G Q R V C K+ + G + V +D+C A RP + + C
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 1607 C-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
C +W S W +C C +V R + C + + C RPV +NC
Sbjct: 685 CGPQWEMSEWSECTAKC--GERSVVTRDIRCSEDEKL------CDPNTRPVGEKNCTGPP 736
Query: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTN--KAVPEHLCSWGPRPANWQRCNIT 1723
C W VS W C+ +CG Q R + V+ +T+ + VPE C +P I
Sbjct: 737 CDRQWTVSDWGPCSGSCG----QGRTIRHVYCKTSDGRVVPESQCQMETKP-----LAIH 787
Query: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
PC + C L+Q RC TCG+
Sbjct: 788 PCGDKNC-------------PAHWLAQDWERCNTTCGR 812
Score = 122 bits (306), Expect = 3e-27
Identities = 115/440 (26%), Positives = 174/440 (39%), Gaps = 104/440 (23%)
Query: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356
++RW+ + PCSATC G A C +R + V V D YC +P+P + C
Sbjct: 565 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 619
Query: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
C PRWE + W+ CS +CG G Q R V C + G +SV
Sbjct: 620 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
Query: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472
C + + C C P+W EWS CT CG+ + R + C + +
Sbjct: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 719
Query: 473 GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWS 532
C P T+P ++ C P PC + W VS+ W
Sbjct: 720 -CDPNTRPVGEKNCTGP-PCDR-----------QW-----------TVSD--------WG 747
Query: 533 ACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFN 591
C+ +CG G +R V C+ + +P +C+ KP + C C
Sbjct: 748 PCSGSCGQGRTIRHVYCK-----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH----- 797
Query: 592 PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN--LCV 649
W + + +C+ +CG GV++ +V C+ +P + C
Sbjct: 798 -------------------WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
Query: 650 TSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILAD 709
+++PP+ +C PC +W WS C+ TCGVG++ RDV C + + V D
Sbjct: 839 LAKKPPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC-----YQGTDIVRGCD 891
Query: 710 ELCRQPKPSTVQACNRFNCP 729
L KP QAC+ CP
Sbjct: 892 PLV---KPVGRQACDLQPCP 908
Score = 119 bits (299), Expect = 2e-26
Identities = 73/248 (29%), Positives = 104/248 (41%), Gaps = 22/248 (8%)
Query: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
++Y W+ CS +C GV A C+ E +++ C RP + + C C
Sbjct: 564 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGREC 622
Query: 667 PARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP---KPSTVQAC 723
RWE WS CS TCG G Q R V C +LS + +V +LC +P + C
Sbjct: 623 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY--SDLCEAAEAVRPEERKTC 680
Query: 724 NRFNCPPAWYPAQWQPCSRTCG-GGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQ 781
C P W ++W C+ CG V R++ C + E C ++P ++
Sbjct: 681 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEK 730
Query: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
C C +W +SDW CS SCG+G R C KT VV + C +I
Sbjct: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAI 786
Query: 842 RPCMLATC 849
PC C
Sbjct: 787 HPCGDKNC 794
Score = 118 bits (296), Expect = 4e-26
Identities = 76/246 (30%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 611 WEYEGFTKCSESCGGGVQEAVVSC---LNKQTREPAEENLCVTSRRP-PQLLKSCNLDPC 666
WE +++CS +CG G Q VV C L+ +LC + P+ K+C C
Sbjct: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
Query: 667 PARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACN 724
+WE+ +WS C+ CG + TRD+ CS ++LC +P + C
Sbjct: 686 GPQWEMSEWSECTAKCGERSVVTRDIRCSE------------DEKLCDPNTRPVGEKNCT 733
Query: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQAC 783
C W + W PCS +CG G R V CK +DG + PE+ C +KP C
Sbjct: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVV--PESQCQMETKPLAIHPC 789
Query: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC-----PPLPFS 838
+CP+ WL DW C+T+CG G + R +C + L G + C PP +
Sbjct: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEEST 848
Query: 839 SSIRPC 844
RPC
Sbjct: 849 CFERPC 854
Score = 104 bits (260), Expect = 7e-22
Identities = 91/337 (27%), Positives = 129/337 (38%), Gaps = 79/337 (23%)
Query: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348
RW + + CS TCG GYQ C+ + S + Y E ++P+
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383
P+ + C A G + ++ D L P R W +
Sbjct: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 744
Query: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442
W CS SCG G R V C D G V V E +C K PC +CP WLA
Sbjct: 745 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 800
Query: 443 QEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVE 502
Q+W C TCG+G++ R+VLC++ + G KP+ + E
Sbjct: 801 QDWERCNTTCGRGVKKRLVLCME---LANG---------------------KPQTRSGPE 836
Query: 503 AKLPWFKQAQELEEGAAVSEEPSF--IPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVA 560
L A++ E + E P F WS CT TCGVG ++R V+C +
Sbjct: 837 CGL-----AKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
Query: 561 DLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDG 597
L KP ++AC PC E P+ + + G
Sbjct: 892 PLV-------KPVGRQACDLQPCPTEPPDDSCQDQPG 921
Score = 99.0 bits (245), Expect = 4e-20
Identities = 75/283 (26%), Positives = 109/283 (38%), Gaps = 39/283 (13%)
Query: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
W + + C+A CG R V +RC + +P RP + C C +W
Sbjct: 689 WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVGEK-NCTGPPCDRQWT 742
Query: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC-VE 1609
V+ W C+ SCG G R V C+ + G P S Q+ +P+ C + C
Sbjct: 743 VSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQ---CQMETKPLAIHPCGDKNCPAH 797
Query: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFC--------QTRDGITLPSEQCSALPRPVSTQNC 1661
W W +CN C V+ R V C QTR G +C +P C
Sbjct: 798 WLAQDWERCNTTC---GRGVKKRLVLCMELANGKPQTRSG-----PECGLAKKPPEESTC 849
Query: 1662 WSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCN 1721
+ C W S W+ CT TCG G + R V+C + L +P Q C+
Sbjct: 850 FERPC-FKWYTSPWSECTKTCG-VGVRMRDVKCYQGTDIVRGCDPLV----KPVGRQACD 903
Query: 1722 ITPC----ENMECRDTT-RYCEKVKQLKLCQLSQFKSRCCGTC 1759
+ PC + C+D C ++ LC + CC +C
Sbjct: 904 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
Score = 89.4 bits (220), Expect = 3e-17
Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354
P +W +D+ PCS +CG G + C RVV + C ++ KP + C
Sbjct: 736 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 789
Query: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
CPA W A W C+++CG G++ R V C+E G +
Sbjct: 790 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 831
Query: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
+C K P C C KW WS CT TCG G+R R V C + GC
Sbjct: 832 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 890
Query: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497
P KP ++ C + P P P +
Sbjct: 891 DPLVKPVGRQACDLQPCPTEPPDD 914
Score = 88.2 bits (217), Expect = 6e-17
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 13/181 (7%)
Query: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNP-AHCAGKVRP-AVQPIACNRRDC 1545
D W+V CS SCG +G + C + V P + C + +P A+ P C ++C
Sbjct: 738 DRQWTVSDWGPCSGSCG-QGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP--CGDKNC 794
Query: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
P+ W+ W C +CG GV+ R V C +L A+G S C +AK+P + C ++
Sbjct: 795 PAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPEC-GLAKKPPEESTCFER 852
Query: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
C +W S W +C C + V+ R V C I C L +PV Q C +
Sbjct: 853 PCFKWYTSPWSECTKTC---GVGVRMRDVKCYQGTDIV---RGCDPLVKPVGRQACDLQP 906
Query: 1666 C 1666
C
Sbjct: 907 C 907
Score = 74.3 bits (181), Expect = 1e-12
Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 9/123 (7%)
Query: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPA-CQQACKKDDCP 789
W + +PCS TC GV +C + DG +E+ +++C A ++P + C +C
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCVRY--DG--VEVDDSYCDALTRPEPVHEFCAGRECQ 623
Query: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
W S W+ECS +CGEG Q R C KML G + V S LC + ++RP TC
Sbjct: 624 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA---AEAVRPEERKTC 680
Query: 850 ARP 852
P
Sbjct: 681 RNP 683
Score = 43.5 bits (101), Expect = 0.002
Identities = 22/56 (39%), Positives = 30/56 (53%), Gaps = 4/56 (7%)
Query: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
T W+AC+RSCGGGV ++ C + + + P N CT +KR Q C Q C
Sbjct: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGP-GNRTCTGTSKR---YQLCRVQEC 105
Score = 39.7 bits (91), Expect = 0.026
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 381 EATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
E T WTACS SCGGG+ S+ C+++ + V C T K Q C + +CP
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQR-RKSVPGPGNRTCTGTSKR--YQLCRVQECP 106
Score = 37.4 bits (85), Expect = 0.13
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)
Query: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86
WSECSRTCG G + + RC + S CE R +TC N C P+
Sbjct: 631 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 690
Query: 87 DFRAQQCSA 95
+C+A
Sbjct: 691 MSEWSECTA 699
Score = 35.4 bits (80), Expect = 0.49
Identities = 24/80 (30%), Positives = 35/80 (43%), Gaps = 8/80 (10%)
Query: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE---PAEENL 647
N ++ L GG D + E+ +T CS SCGGGV CL ++ + P
Sbjct: 32 NSPTSNSLEGGT-DATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC 90
Query: 648 CVTSRRPPQLLKSCNLDPCP 667
TS+R + C + CP
Sbjct: 91 TGTSKR----YQLCRVQECP 106
Score = 35.0 bits (79), Expect = 0.65
Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 736 QWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSE 791
+W CSR+CGGGV +E C Q+ T SK Q C+ +CP +
Sbjct: 55 KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR--YQLCRVQECPPD 108
Score = 32.3 bits (72), Expect = 4.2
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 41 PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91
PWSEC++TCG G +C + C+ + + + C CP E D Q
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,463,095
Number of Sequences: 37866
Number of extensions: 4071450
Number of successful extensions: 19724
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 184
Number of HSP's that attempted gapping in prelim test: 9595
Number of HSP's gapped (non-prelim): 4857
length of query: 1762
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1646
effective length of database: 13,855,062
effective search space: 22805432052
effective search space used: 22805432052
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.