Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 153792294
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153792294 myopalladin [Homo sapiens]
(1320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153792294 myopalladin [Homo sapiens] 2664 0.0
gi|93102361 palladin [Homo sapiens] 578 e-164
gi|209693444 myotilin isoform b [Homo sapiens] 248 2e-65
gi|5803106 myotilin isoform a [Homo sapiens] 248 2e-65
gi|110349721 titin isoform novex-3 [Homo sapiens] 223 9e-58
gi|110349719 titin isoform N2-A [Homo sapiens] 223 9e-58
gi|110349717 titin isoform novex-2 [Homo sapiens] 223 9e-58
gi|110349713 titin isoform novex-1 [Homo sapiens] 223 9e-58
gi|110349715 titin isoform N2-B [Homo sapiens] 223 9e-58
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens] 141 4e-33
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 141 4e-33
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 131 4e-30
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 131 4e-30
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 113 1e-24
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 113 1e-24
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 113 1e-24
gi|157785645 SPEG complex locus [Homo sapiens] 112 3e-24
gi|118572606 hemicentin 1 [Homo sapiens] 109 2e-23
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 108 3e-23
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 108 4e-23
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 108 4e-23
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 105 2e-22
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 105 3e-22
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 102 3e-21
gi|224994173 roundabout 1 isoform d [Homo sapiens] 100 7e-21
gi|224994171 roundabout 1 isoform c [Homo sapiens] 100 7e-21
gi|19743806 roundabout 1 isoform b [Homo sapiens] 100 7e-21
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 100 7e-21
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 100 7e-21
gi|4506569 roundabout 1 isoform a [Homo sapiens] 100 7e-21
>gi|153792294 myopalladin [Homo sapiens]
Length = 1320
Score = 2664 bits (6904), Expect = 0.0
Identities = 1320/1320 (100%), Positives = 1320/1320 (100%)
Query: 1 MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDL 60
MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDL
Sbjct: 1 MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDL 60
Query: 61 PDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQD 120
PDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQD
Sbjct: 61 PDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQD 120
Query: 121 NPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKN 180
NPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKN
Sbjct: 121 NPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKN 180
Query: 181 HKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQ 240
HKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQ
Sbjct: 181 HKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQ 240
Query: 241 AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV 300
AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV
Sbjct: 241 AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV 300
Query: 301 RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG
Sbjct: 301 RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
Query: 361 VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT
Sbjct: 361 VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
Query: 421 NYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
NYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD
Sbjct: 421 NYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN 540
FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN
Sbjct: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN 540
Query: 541 NGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHF 600
NGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHF
Sbjct: 541 NGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHF 600
Query: 601 NLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDS 660
NLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDS
Sbjct: 601 NLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDS 660
Query: 661 TQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSL 720
TQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSL
Sbjct: 661 TQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSL 720
Query: 721 ARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSI 780
ARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSI
Sbjct: 721 ARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSI 780
Query: 781 QNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAI 840
QNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAI
Sbjct: 781 QNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAI 840
Query: 841 PPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQ 900
PPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQ
Sbjct: 841 PPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQ 900
Query: 901 QEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGS 960
QEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGS
Sbjct: 901 QEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGS 960
Query: 961 PVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIM 1020
PVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIM
Sbjct: 961 PVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIM 1020
Query: 1021 AANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPG 1080
AANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPG
Sbjct: 1021 AANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPG 1080
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD
Sbjct: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP
Sbjct: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
Query: 1201 PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR
Sbjct: 1201 PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
Query: 1261 LDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL 1320
LDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL
Sbjct: 1261 LDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL 1320
>gi|93102361 palladin [Homo sapiens]
Length = 1106
Score = 578 bits (1489), Expect = e-164
Identities = 349/901 (38%), Positives = 492/901 (54%), Gaps = 128/901 (14%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
AAP F + L++ +EG V ECRV G P+P+V W+ EG + ++PD +I
Sbjct: 269 AAPRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQI-------HC 321
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTN 552
E ++ TL+IAE F +D+G +TC A+N G+ ++ A++ + G S+ S + + +
Sbjct: 322 EGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEG---ASSTDSDSESLAFKS 378
Query: 553 LAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEAS 612
A PQ + ++ + L + + P+ +
Sbjct: 379 RAGAMPQAQ---------------------------KKTTSVSLTIGSSSPKTGVTTAVI 411
Query: 613 SEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLL 672
V + P S+ R +G T PPV K +L +T + + QV++
Sbjct: 412 QPLSVPVQQVHSPTSYLCRPDGTTTAYF---------PPVFTK-ELQNTAVAE--GQVVV 459
Query: 673 EQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNT 732
+ +++ PP + F + +S P K+ + S A P+
Sbjct: 460 LECRVRGAPPLQVQWFRQGSEIQDS---PDFRILQKKPR-------STAEPEEI---CTL 506
Query: 733 TAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNE------PLP 786
A P + +FT S+ T S L+V+ + + S + N P P
Sbjct: 507 VIAETFPEDAGIFTCSARNDYGSAT-STAQLVVTSANTENCSYESMGESNNDHFQHFPPP 565
Query: 787 PGPTEPTPPPFTFSIPSGNQFQ-------PRCVSPIPVSPTSRIQNPV-------AFLSS 832
P E + PS Q R + + R N V ++
Sbjct: 566 PPILETSSLELASKKPSEIQQVNNPELGLSRAALQMQFNAAERETNGVHPSRGVNGLING 625
Query: 833 VLPSLPAIPPTNAMGLPRSAP----SMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLG 888
S ++P + P P + P G KK +++ + +D+ I+ TK+AVI+DL
Sbjct: 626 KANSNKSLPTPAVLLSPTKEPPPLLAKPKLGFPKKASRTARIASDEEIQGTKDAVIQDLE 685
Query: 889 KKITFSDVRPNQ-----------------------------------QEYKISSFEQRLM 913
+K+ F + N QEYK+SS EQRL+
Sbjct: 686 RKLRFKEDLLNNGQPRLTYEERMARRLLGADSATVFNIQEPEEETANQEYKVSSCEQRLI 745
Query: 914 NEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPV 973
+EIE+RLER+PVDES DE+Q+ ++P +AP F+ +LKH+++ EG PVTFTC++ G P
Sbjct: 746 SEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPK 805
Query: 974 PKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGH 1033
PK+YWFKDGKQIS +++H ++R+ DGTCSLH ++T DDDGNYTIMAANPQGRISC+G
Sbjct: 806 PKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANPQGRISCTGR 865
Query: 1034 LMVQSLPIRSRLTSAGQSH------RGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEG 1087
LMVQ++ R R + H R RSR + EP+QERFFRPHFLQAPGD+ EG
Sbjct: 866 LMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEG 925
Query: 1088 RLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCI 1147
+LCR+DCKVSGLP P+L+W L+G+PV PD++HKMLVRE GVHSL+I+P+T RDAG Y CI
Sbjct: 926 KLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCI 985
Query: 1148 ATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKK 1207
ATN+ GQNSFSLEL V AKE K PV +EKLQN GV +G+PVRLECRV+G+PPP +WKK
Sbjct: 986 ATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKK 1045
Query: 1208 DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQW 1267
+NE++ + +R+SMHQD GY CLLIQ A K DAGWYT+SAKNEAGIVSCTARLD+Y
Sbjct: 1046 ENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYISR 1105
Query: 1268 H 1268
H
Sbjct: 1106 H 1106
Score = 341 bits (874), Expect = 3e-93
Identities = 256/688 (37%), Positives = 337/688 (48%), Gaps = 104/688 (15%)
Query: 38 SSNPCHFGSPSGAAEGGGGQDDLPDLSAFLSQEELDESVNLARLAINYDPLEKADETQAR 97
SS+ + S S E D P LSAFLSQEE+++S++LAR AI E D +
Sbjct: 5 SSHESFYDSLSDMQEESKNTDFFPGLSAFLSQEEINKSLDLARRAIADSETEDFDSEKEI 64
Query: 98 KRL------------SPDQMKHSPNLSFEPNFCQDNPRSPTSSKE-----SPQEAK---- 136
++ S + K + S P + P P + K+ SP +
Sbjct: 65 SQIFSTSPASLCEHPSHKETKLGEHASRRPQDNRSTPVQPLAEKQTKSISSPVSKRKPAM 124
Query: 137 -----RPQYC----------SETQSKKV---------------FLNKAADFIEELSSLFK 166
RP Y ++T S V +KAA+ IEEL+S+FK
Sbjct: 125 SPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQRKGGPQSQLCDKAANLIEELTSIFK 184
Query: 167 SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNH 226
+ + P E+SS S + + S + A
Sbjct: 185 AAKPRNRSPNG----------------ESSSPDSGYLSPKNQPSALLSASAS------QS 222
Query: 227 ALEQQEAKRREAEQAASEAAGGDT----TPGSSPSSLYYEEPLGQP--PRFTQKLRSREV 280
+E Q RE + + D P + S L P PRF QKLRS+EV
Sbjct: 223 PMEDQGEMEREVKSPGARHCYQDNQDLAVPHNRKSHPQPHSALHFPAAPRFIQKLRSQEV 282
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAGNLHSLTIAEAFEEDTGRY 339
EG+RV L+C V G P P+VRW+CEGKEL N+PDI I + G+LH+L IAEAFE+DTGRY
Sbjct: 283 AEGSRVYLECRVTGNPTPRVRWFCEGKELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRY 342
Query: 340 SCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVP 399
+C A+N G+D+TSAE++IEG SS+DS+ + + P + S I + P
Sbjct: 343 TCLATNPSGSDTTSAEVFIEGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSP 402
Query: 400 QA--QHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA-APVFTKMLQNLSASEGQLVVFEC 456
+ V QP +QQ SPT+YL DG PVFTK LQN + +EGQ+VV EC
Sbjct: 403 KTGVTTAVIQPLSVPVQQVHSPTSYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLEC 462
Query: 457 RVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
RV+GAP +V+W+R+G+ I+DSPDFRILQKKPRS AEPEEICTLVIAE F ED+G FTC+
Sbjct: 463 RVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCS 522
Query: 517 ASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKP 576
A N YG+ +S AQL V + N S S + N P PP E S+E K
Sbjct: 523 ARNDYGSATSTAQLVVTSAN--TENCSYESMGESNNDHFQHFPPPPPILETSSLELASKK 580
Query: 577 KLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQA 636
E VN N SR L++ FN E + GV +R NG+A
Sbjct: 581 PSEIQQVN-NPELGLSRAALQMQFNAAERETN-------GVHPSR-----GVNGLINGKA 627
Query: 637 TKT---PEPS---SPVKEPPPVLAKPKL 658
P P+ SP KEPPP+LAKPKL
Sbjct: 628 NSNKSLPTPAVLLSPTKEPPPLLAKPKL 655
Score = 87.0 bits (214), Expect = 1e-16
Identities = 85/335 (25%), Positives = 131/335 (39%), Gaps = 75/335 (22%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQA---GN 322
G P F KL+ ++ EG V C V G P P++ W+ +GK++ D + +Q G
Sbjct: 774 GMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGT 833
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV--------------------S 362
T A ++D G Y+ A+N G S + + ++ V S
Sbjct: 834 CSLHTTASTLDDD-GNYTIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRS 892
Query: 363 SSDSEGDPNKEEMNRIQKPNEVSSP----------------------PTTSAVI--PPAV 398
S GD N+ R +P+ + +P P S + P
Sbjct: 893 RSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVR 952
Query: 399 PQAQH-----------LVAQP---RVATIQQCQSPTNYLQGLDGKPIIAA-------PVF 437
P + H L+ +P R A I C + Q ++ A PVF
Sbjct: 953 PDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVF 1012
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
+ LQN ++G V ECRV G P P++ W +E + S D + + I
Sbjct: 1013 IEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGY-----I 1067
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
C L+I ED+G +T +A N+ G VS A+L V
Sbjct: 1068 C-LLIQGATKEDAGWYTVSAKNEAGIVSCTARLDV 1101
Score = 71.6 bits (174), Expect = 5e-12
Identities = 59/223 (26%), Positives = 94/223 (42%), Gaps = 38/223 (17%)
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET-GVHSLLIDPLTQRDAGTY 1144
EG C+V+G P P++ W +G+ + P + H + R+ G SL T D G Y
Sbjct: 790 EGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNY 849
Query: 1145 KCIATNKTGQNSFSLELSVVA----------------------------------KEVKK 1170
+A N G+ S + L V A +E
Sbjct: 850 TIMAANPQGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFF 909
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYA 1229
P L+ + V EG R++C+V G+P P W+ D + + P + ++ + ++ G
Sbjct: 910 RPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVREN--GVH 967
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIP 1272
L+I+P DAG YT A N AG S + L + A+ H+ P
Sbjct: 968 SLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPP 1010
Score = 58.5 bits (140), Expect = 4e-08
Identities = 37/97 (38%), Positives = 56/97 (57%), Gaps = 6/97 (6%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD---IHIVQAGNL 323
+PP F +KL++ V +G V+L+C V+G+PPPQ+ W E + L +S D +H G +
Sbjct: 1008 KPPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYI 1067
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSA--EIYI 358
L I A +ED G Y+ A N G S +A ++YI
Sbjct: 1068 -CLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVYI 1103
>gi|209693444 myotilin isoform b [Homo sapiens]
Length = 314
Score = 248 bits (634), Expect = 2e-65
Identities = 130/311 (41%), Positives = 192/311 (61%), Gaps = 17/311 (5%)
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071
DD G A + Q S L V + +RSR TS G + D++ +QE+F+
Sbjct: 19 DDSG-----AQDSQQHNSEHARLQVPTSQVRSRSTSRGDVN---------DQDAIQEKFY 64
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131
P F+Q P +M EGR CR+D KVSGLP P+++W LNG+ V D HKM+V E G+HSL
Sbjct: 65 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 124
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
+ + + DAG Y C+A N+ G+ +F+++L V+AKE K+AP+ + K Q+ V EG V+L
Sbjct: 125 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 184
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
EC++ +PPP +WK++NE + +RIS++QD TG LLI+ K DAGWYT+SA NE
Sbjct: 185 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 244
Query: 1252 AGIVSCTARLDIYAQWHHQIPPP--MSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSC 1309
AG+ +C RLD+ A+ + +P P + VRP+ S+Y +L KGL++ AF+ E
Sbjct: 245 AGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNP-EGEFQRLA 303
Query: 1310 SSRSVVESDEL 1320
+ + ES+EL
Sbjct: 304 AQSGLYESEEL 314
Score = 75.9 bits (185), Expect = 2e-13
Identities = 60/233 (25%), Positives = 97/233 (41%), Gaps = 30/233 (12%)
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
K P F + ++ + EG K+ G+P P V W+ +G+ + + H KM G
Sbjct: 62 KFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLH-KMIVSEKG 120
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
SL E + D G Y +A N G + + L V +
Sbjct: 121 LHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLA---------------------- 158
Query: 1061 RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHK 1120
+E P F+ P EG +L+C++S +PPP+L W N + V +
Sbjct: 159 ------KEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRI 212
Query: 1121 MLVRE-TGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP 1172
L ++ TG +LLI + ++DAG Y A N+ G + + L V A+ + P
Sbjct: 213 SLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLP 265
Score = 61.2 bits (147), Expect = 6e-09
Identities = 43/170 (25%), Positives = 72/170 (42%), Gaps = 4/170 (2%)
Query: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQL 288
+Q ++ + S+ T+ G +E PPRF Q + + EG ++
Sbjct: 27 QQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKF-YPPRFIQVPENMSIDEGRFCRM 85
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIH--IVQAGNLHSLTIAEAFEEDTGRYSCFASNI 346
D V G+P P V WY G+ ++ S D+H IV LHSL D G Y+C A N
Sbjct: 86 DFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 144
Query: 347 YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP 396
G + + ++ + + K + ++ + + V SA+ PP
Sbjct: 145 AGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 194
Score = 57.8 bits (138), Expect = 7e-08
Identities = 31/114 (27%), Positives = 55/114 (48%)
Query: 927 ESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQIS 986
E+ +Q D + AP+F + + +V EG V C+I IP PK++W ++ + +
Sbjct: 147 EATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQ 206
Query: 987 KRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ + ++ G +L I+ D G YT+ A N G +C+ L V + P
Sbjct: 207 FNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARP 260
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 7/102 (6%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F ++ +N+S EG+ + +V G P+P V WY G ++ S D + +
Sbjct: 66 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLH------KMIVSE 118
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ + +L+ V A D+G + C A N+ G + QL V E
Sbjct: 119 KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 160
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP+F Q+ EG V EC++ P PK+ W R +++ + D L +
Sbjct: 164 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV- 222
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV--RGNEDL 538
TL+I +V +D+G +T +A N+ G + +L V R N+ L
Sbjct: 223 -----TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTL 264
Score = 42.0 bits (97), Expect = 0.004
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT- 327
P F K +S++V EG V+L+C + IPPP++ W + ++ + D + N +T
Sbjct: 165 PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTL 224
Query: 328 -IAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
I + ++D G Y+ A N G + + +
Sbjct: 225 LIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 254
>gi|5803106 myotilin isoform a [Homo sapiens]
Length = 498
Score = 248 bits (634), Expect = 2e-65
Identities = 130/311 (41%), Positives = 192/311 (61%), Gaps = 17/311 (5%)
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071
DD G A + Q S L V + +RSR TS G + D++ +QE+F+
Sbjct: 203 DDSG-----AQDSQQHNSEHARLQVPTSQVRSRSTSRGDVN---------DQDAIQEKFY 248
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131
P F+Q P +M EGR CR+D KVSGLP P+++W LNG+ V D HKM+V E G+HSL
Sbjct: 249 PPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSL 308
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
+ + + DAG Y C+A N+ G+ +F+++L V+AKE K+AP+ + K Q+ V EG V+L
Sbjct: 309 IFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKL 368
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
EC++ +PPP +WK++NE + +RIS++QD TG LLI+ K DAGWYT+SA NE
Sbjct: 369 ECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNE 428
Query: 1252 AGIVSCTARLDIYAQWHHQIPPP--MSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSC 1309
AG+ +C RLD+ A+ + +P P + VRP+ S+Y +L KGL++ AF+ E
Sbjct: 429 AGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNP-EGEFQRLA 487
Query: 1310 SSRSVVESDEL 1320
+ + ES+EL
Sbjct: 488 AQSGLYESEEL 498
Score = 100 bits (250), Expect = 7e-21
Identities = 110/498 (22%), Positives = 190/498 (38%), Gaps = 93/498 (18%)
Query: 718 FSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGG 777
F+ RPK+F S N + + P + SS + + S +
Sbjct: 2 FNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSH 61
Query: 778 LSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSL 837
+++ + P P + +P T+ Q+P +FLSS+LPS
Sbjct: 62 ITMSSSAFPASPQQHAGS-----------------NPGQRVTTTYNQSPASFLSSILPSQ 104
Query: 838 PAIPPTNAMGLPRSAPSMPSQGLAKK--NTKSPQPVN--------DDNIRETKNAVIRDL 887
P N+ +P + S Q A + N K Q N D I+ +K A+I+DL
Sbjct: 105 PDY---NSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDL 161
Query: 888 GKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEI------QHD------ 935
+K+ D + +++ +E+++ + V ++ D+ QH+
Sbjct: 162 ERKLKCKDTLLHNGNQRLT-YEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARL 220
Query: 936 EIPTG--------------------KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPK 975
++PT K P F + ++ + EG K+ G+P P
Sbjct: 221 QVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPD 280
Query: 976 VYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLM 1035
V W+ +G+ + + H KM G SL E + D G Y +A N G + + L
Sbjct: 281 VSWYLNGRTVQSDDLH-KMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLD 339
Query: 1036 VQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCK 1095
V + +E P F+ P EG +L+C+
Sbjct: 340 VLA----------------------------KEHKRAPMFIYKPQSKKVLEGDSVKLECQ 371
Query: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRE-TGVHSLLIDPLTQRDAGTYKCIATNKTGQ 1154
+S +PPP+L W N + V + L ++ TG +LLI + ++DAG Y A N+ G
Sbjct: 372 ISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGV 431
Query: 1155 NSFSLELSVVAKEVKKAP 1172
+ + L V A+ + P
Sbjct: 432 TTCNTRLDVTARPNQTLP 449
Score = 61.2 bits (147), Expect = 6e-09
Identities = 43/170 (25%), Positives = 72/170 (42%), Gaps = 4/170 (2%)
Query: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQL 288
+Q ++ + S+ T+ G +E PPRF Q + + EG ++
Sbjct: 211 QQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKF-YPPRFIQVPENMSIDEGRFCRM 269
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIH--IVQAGNLHSLTIAEAFEEDTGRYSCFASNI 346
D V G+P P V WY G+ ++ S D+H IV LHSL D G Y+C A N
Sbjct: 270 DFKVSGLPAPDVSWYLNGRTVQ-SDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNR 328
Query: 347 YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP 396
G + + ++ + + K + ++ + + V SA+ PP
Sbjct: 329 AGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPP 378
Score = 52.8 bits (125), Expect = 2e-06
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 7/102 (6%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F ++ +N+S EG+ + +V G P+P V WY G ++ S D + +
Sbjct: 250 PRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQ-SDDLH------KMIVSE 302
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ + +L+ V A D+G + C A N+ G + QL V E
Sbjct: 303 KGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKE 344
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 8/107 (7%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP+F Q+ EG V EC++ P PK+ W R +++ + D L +
Sbjct: 348 APMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRV- 406
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV--RGNEDL 538
TL+I +V +D+G +T +A N+ G + +L V R N+ L
Sbjct: 407 -----TLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTL 448
Score = 42.0 bits (97), Expect = 0.004
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 2/90 (2%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT- 327
P F K +S++V EG V+L+C + IPPP++ W + ++ + D + N +T
Sbjct: 349 PMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTL 408
Query: 328 -IAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
I + ++D G Y+ A N G + + +
Sbjct: 409 LIKDVNKKDAGWYTVSAVNEAGVTTCNTRL 438
>gi|110349721 titin isoform novex-3 [Homo sapiens]
Length = 5604
Score = 223 bits (568), Expect = 9e-58
Identities = 144/450 (32%), Positives = 227/450 (50%), Gaps = 47/450 (10%)
Query: 878 ETKNAVIRD-LGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD- 935
E + A+IR + K QE+ ISSFE+RL+ EIE+R+ +T ++E +E +
Sbjct: 1219 EKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEK 1278
Query: 936 ---EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
+I + + FD R+K++R+ EG VTF CK+ G P+PK+ W+KDGK+I K E
Sbjct: 1279 MAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRI-KHGERY 1337
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL------------- 1039
+M DG SL I +D+G YT A+N +G CSG L V+
Sbjct: 1338 QMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLE 1397
Query: 1040 ----------------PIR--------SRLTSAGQSHRGRS---RVQERDKEPLQERFFR 1072
PIR +R++ A S S R++E D+ L ER ++
Sbjct: 1398 PVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL-ERLYK 1456
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F+ P EG+ R D KV G P PE W +GQ ++ D +HK++++E G SL+
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I P T D+G + +A N+ G++S S+ L+V A E + P+ +EKL+N + EG + ++
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1576
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
R G P P W K+++ I + + T G A L I D+ WYT +A N+A
Sbjct: 1577 VRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKA 1636
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS 1282
G + ++++ ++ P + P G+
Sbjct: 1637 GRDTTRCKVNVEVEFAEPEPERKLIIPRGT 1666
Score = 105 bits (262), Expect = 3e-22
Identities = 78/264 (29%), Positives = 111/264 (42%), Gaps = 35/264 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L++ V EG V L+C + G P P V WY E ++E+S D I + L
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 1001
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I EAF ED+GR++C A N GT STS + ++ + E
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE-------------------- 1041
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKP-IIAAPVFTKMLQNLSA 446
T+AV + + V V + G P I PV K++
Sbjct: 1042 --TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV----- 1094
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG VVF C+V G P P V W + G + +++ K C LVI+ F
Sbjct: 1095 -EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGE------CKLVISMTF 1147
Query: 507 AEDSGCFTCTASNKYGTVSSIAQL 530
A+D+G +T NK+G S+ A L
Sbjct: 1148 ADDAGEYTIVVRNKHGETSASASL 1171
Score = 100 bits (249), Expect = 9e-21
Identities = 97/368 (26%), Positives = 142/368 (38%), Gaps = 77/368 (20%)
Query: 173 IRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQE 232
+R R+ K +E Q V++ + D+ + + I R V +E++
Sbjct: 3147 VRIRSIKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYV---VERRI 3202
Query: 233 AKRREAEQAASEAAGGDTTPGSSPSS--LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+ +E S+A G + SS LY P +PP+ Q+L+ V G +
Sbjct: 3203 HRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAP--EPPQVLQELQPVTVQSGKPARFCA 3260
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
++ G P P++ WY E + L + G ++L + EAF ED Y+C A N YG
Sbjct: 3261 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVA 3320
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRV 410
+TSA + +E EV SP V PPA+
Sbjct: 3321 TTSASLSVE---------------------VPEVVSPDQEMPVYPPAI------------ 3347
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYR 470
LQ+ SEGQ F+CRV G KV WY
Sbjct: 3348 ---------------------------ITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYS 3379
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+ I+ S FR M + E+ L IAE + ED G +T ASN G VSS A L
Sbjct: 3380 KDKKIKPSRFFR--------MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3431
Query: 531 HVRGNEDL 538
+ E +
Sbjct: 3432 SLEAPESI 3439
Score = 94.0 bits (232), Expect = 9e-19
Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 37/255 (14%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + L+ V EGS TF I G PVP+V WF+DG+ IS DG
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + T + G Y++ A N G+ + + L+V++ +
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-----------------------ET 101
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
P P+F+Q M +G RL +V+G+P P + + +G + + +
Sbjct: 102 AP-------PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQ-IS 153
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE---VKKAPVILEKLQN 1180
+E ++SLLI D+GTY ATN G+ + + EL V +E KK I+ Q
Sbjct: 154 QEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ- 212
Query: 1181 CGVPEGHPVRLECRV 1195
+ E R+E ++
Sbjct: 213 --ISESRQTRIEKKI 225
Score = 91.7 bits (226), Expect = 4e-18
Identities = 58/165 (35%), Positives = 88/165 (53%), Gaps = 12/165 (7%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F Q+L+S V +G++V+L V GIP P V++Y +G E+++S D I Q G+L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL 162
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG--------VSSSDSEGDPNKEEMNRIQ 379
IAEA+ ED+G YS A+N G +++AE+ ++G + S ++ RI+
Sbjct: 163 IAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIE 222
Query: 380 KPNE----VSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
K E S T VI A Q PR+ + +SPT
Sbjct: 223 KKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSPT 267
Score = 89.7 bits (221), Expect = 2e-17
Identities = 79/306 (25%), Positives = 130/306 (42%), Gaps = 33/306 (10%)
Query: 865 TKSPQPV------NDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEF 918
T SPQ + ++ +++E + V K +T + P+ + I S + N ++
Sbjct: 5304 TPSPQEIVLEVELSEKDVKEFEKQV-----KIVTVPEFTPDHKSM-IVSLDVLPFNFVDP 5357
Query: 919 RLERTPVDESDDEIQHD--EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKV 976
++ ++ + +I + E+P + I PI D F++ E S F C ++GIP P+V
Sbjct: 5358 NMDSREGEDKELKIDLEVFEMPP-RFIMPICD-----FKIPENSDAVFKCSVIGIPTPEV 5411
Query: 977 YWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMV 1036
W+K+ I N + E G+ +L I + D Y A N G C G L +
Sbjct: 5412 KWYKEYMCIEPDNIKYVISEE-KGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTM 5470
Query: 1037 QSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFR-------PHFLQAPGDMVAHEGRL 1089
I + + + + K + FF P F++ D A G
Sbjct: 5471 GDSEIFAVIAKKSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPPRFIKGISDCYAPIGTA 5530
Query: 1090 CRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE--TGVHSLLIDPLTQRDAGTYKCI 1147
C V G P P + W +G+ V + V E TG H+L I L + D G Y+C+
Sbjct: 5531 AYFQCLVRGSPRPTVYWYKDGKLV---QGRRFTVEESGTGFHNLFITSLVKSDEGEYRCV 5587
Query: 1148 ATNKTG 1153
ATNK+G
Sbjct: 5588 ATNKSG 5593
Score = 88.6 bits (218), Expect = 4e-17
Identities = 101/387 (26%), Positives = 143/387 (36%), Gaps = 79/387 (20%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F K +K +V E F C+ V P V W KD +++ + + K+++E L I
Sbjct: 3060 FRKHIKDIKVLEKKRAMFECE-VSEPDITVQWMKDDQEL-QITDRIKIQKE-KYVHRLLI 3116
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR--------- 1057
ST D G YT++A G +S + L V+ +R R + R
Sbjct: 3117 PSTRMSDAGKYTVVAG---GNVS-TAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNE 3172
Query: 1058 -----------------VQERDKEPLQERFFR---------------------------- 1072
VQER K ++ R R
Sbjct: 3173 DDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLY 3232
Query: 1073 ------PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P LQ + G+ R +SG P P+++W Q + K L +
Sbjct: 3233 VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL-HDG 3291
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA--------PVILEKL 1178
++LL+ DA Y C A N G + S LSV EV P I+ L
Sbjct: 3292 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3351
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ EG P R +CRV G V ++ KD + P R++ +DT L I A
Sbjct: 3352 QDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ---LEIAEAYP 3408
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYA 1265
D G YT A N G VS TA L + A
Sbjct: 3409 EDEGTYTFVASNAVGQVSSTANLSLEA 3435
Score = 86.7 bits (213), Expect = 1e-16
Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 9/202 (4%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR-ETGVHSL 1131
P F Q +V EG + +SG P PE++W +GQ + + + G L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I +T+ ++G Y ATN +GQ + + EL V A+ P +++LQ+ V +G VRL
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAP--PNFVQRLQSMTVRQGSQVRL 123
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ RV G+P PV + +D I + + +IS D LLI A D+G Y+++A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYS---LLIAEAYPEDSGTYSVNATN 180
Query: 1251 EAGIVSCTARLDIYAQWHHQIP 1272
G + TA ++ Q ++P
Sbjct: 181 SVGRATSTA--ELLVQGEEEVP 200
Score = 86.3 bits (212), Expect = 2e-16
Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 21/273 (7%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--DIHIVQAGNLHSLTI 328
F ++++ + EG V C + G P P++ WY +GK +++ + +Q G SL I
Sbjct: 1293 FDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRA-SLRI 1351
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEG-DPNKEEMNRIQ--KPNEVS 385
ED G Y+ FASNI G S ++Y+E + + P E ++RI+ P VS
Sbjct: 1352 PVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1411
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI--IAAPVFTKMLQN 443
P + P + A+ A+ A + SP L+ D + + PVF +
Sbjct: 1412 RSPIRMS--PARMSPARMSPARMSPARM----SPGRRLEETDESQLERLYKPVFVLKPVS 1465
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
EGQ F+ +V G P P+ W+ +G I + +++ K+ + +L+I
Sbjct: 1466 FKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-------SLIIV 1518
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
DSG +T A N+ G S L V E
Sbjct: 1519 PATPSDSGEWTVVAQNRAGRSSISVILTVEAVE 1551
Score = 85.1 bits (209), Expect = 4e-16
Identities = 102/468 (21%), Positives = 177/468 (37%), Gaps = 95/468 (20%)
Query: 163 SLFKSHSSKRIRPRACKNHKSKLES--QNKVMQENSSSFSDLSERRERSSVP-------I 213
SL K H I + +LE N + E+S+ +++ E+ E P
Sbjct: 3817 SLPKDHLYGEILVNENTQARGQLEEIMANTTIGESSTYITNVCEKEEVYETPENVSQAIT 3876
Query: 214 PIPADTRDNEVNHALEQQEAKRR-------EAEQAASEAAGGDTTPGSSPSSLYYEE--- 263
P +++ VN ++ A R E + +AS T + ++E
Sbjct: 3877 PHASESFGTLVNVEESEEIASERIKKDDLRELQLSASTRIDEFKTEQKEENMRFFENSFR 3936
Query: 264 --PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG 321
P PP F Q++ S+EV EG C G P P V WY + + + I
Sbjct: 3937 KRPQRCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLE 3996
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDP---------NK 372
N LT++ ++ G +C N YGT T++ + ++ D + +
Sbjct: 3997 NYSILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQKHDVKAHKVPVFHDYLDEE 4056
Query: 373 EEMNRIQKPNEVSSPPT------------TSAVIPPA-------------------VPQA 401
EE+ + + + P T+ +PP+ +P+
Sbjct: 4057 EELALVFDQAKGAHPSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVEIQVTAATPIPEQ 4116
Query: 402 --------QHLVAQPRVATIQQC-QSPTN---YLQGLDGKPIIAAPVFTKMLQNLSASEG 449
Q +P+ Q QSP + +L + +P + +M ++ EG
Sbjct: 4117 DKESKEVFQTEELEPKAMPQDQVTQSPKHRFVFLSDITNEP---PKMLQEMPKHARCREG 4173
Query: 450 QLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI-CT--LVIAEVF 506
++ EC + G P P V W++ G L++ + F+ EE+ C+ L I +V
Sbjct: 4174 DSIILECLISGEPQPVVTWFQNGVLLKQNQKFQF-----------EEVNCSHQLYIKDVN 4222
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHV-----RGNEDLSNNGSLHSANS 549
++DSG + C A N G V S++ L V R N N G ++ S
Sbjct: 4223 SQDSGKYKCVAENNSGAVESVSDLTVEPVTYRENSQFENIGEIYGKYS 4270
Score = 85.1 bits (209), Expect = 4e-16
Identities = 182/904 (20%), Positives = 307/904 (33%), Gaps = 197/904 (21%)
Query: 485 QKKPRSMAEPEEICTLV--IAEVFAEDSGC---FTCTASNKYGTVSSIAQLHVRGNEDLS 539
++KP + E EE CTL +A +D G T + G V LH +
Sbjct: 4772 EEKPLGVGEMEEECTLEPELAAFPKQDGGTQEYTDATLEDHRGDVQEADTLHRQ------ 4825
Query: 540 NNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVH 599
S + L E Q +P ++ + K + NE S+ G +
Sbjct: 4826 -----LSLSQCFPLLMTEEQQNPGEQISTNIHASGEEKCYEEVQVQNEASFSTLEGEMIE 4880
Query: 600 F----NLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAK 655
N+P+ D EA ++ Q + PE + ++ ++
Sbjct: 4881 TSFSQNIPKLD-------EAHTTEAAESETSLTQYLLAAGKREVPE-TKDTRDQAKLVQS 4932
Query: 656 PKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSS 715
+ S +++++ + E + + P +++ + + Q P S
Sbjct: 4933 ESITSMEVEEVTFNTVYEYYNQKQESLGRPLSPESDISIGVGSTTSEEISELDQFYTPPS 4992
Query: 716 QTFSLARPK----YFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQ 771
PK YF PS T +++ V S+ + S S +
Sbjct: 4993 SVEYFESPKSPDLYFNPSDITKQSSIHSGGETVERYSTPLGEVAERYSTPS--EGEVGER 5050
Query: 772 TKSPGGLSIQNEPLPPGPT---EPTPPPFT---FSIPSGNQFQPRCVSPIPVSPTSRIQN 825
+P G +++ PPG T TPP T +S P G + R +P P R
Sbjct: 5051 YSTPPGETLERYSTPPGETLERYSTPPGETLERYSTPPGETLE-RYSTP-PGETLERYST 5108
Query: 826 PVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIR 885
P P A+ S+P+ G P P +
Sbjct: 5109 P---------------PGEAL----ERYSIPTGG--------PNPTG----------TFK 5131
Query: 886 DLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAP 945
KI D PN+ Y + E+R +R + E + +E+P P
Sbjct: 5132 TYPSKIEREDGTPNEHFY--TPTEERGSAYEIWRSDSFGTPNEAIEPKDNEMP------P 5183
Query: 946 IFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLH 1005
F + L +V E + + F ++ G+PVP V W+++ K + + +E KM R G+ CSL
Sbjct: 5184 SFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRN-KSLLEPDERIKMERVGN-VCSLE 5241
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHL-------MVQSLP---IRSRLTSAGQSHRGR 1055
I + + G Y A N G ++ V +LP + H
Sbjct: 5242 ISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHTTS 5301
Query: 1056 SR------------VQERDKEPLQERF-------FRP--------------HFLQAPGDM 1082
SR + E+D + +++ F P +F+ D
Sbjct: 5302 SRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLPFNFVDPNMDS 5361
Query: 1083 VAHEGRLCRLDCKVSGLPP----------------------------PELTWLLNGQPVL 1114
E + ++D +V +PP PE+ W +
Sbjct: 5362 REGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIE 5421
Query: 1115 PDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--------NSFSLELSVVAK 1166
PD ++ E G H+L I + D+ TY+C A N G+ S +V+AK
Sbjct: 5422 PDNIKYVISEEKGSHTLKIRNVCLSDSATYRCRAVNCVGEAICRGFLTMGDSEIFAVIAK 5481
Query: 1167 E---------------------------VKKAPVILEKLQNCGVPEGHPVRLECRVIGMP 1199
+ V+ P ++ + +C P G +C V G P
Sbjct: 5482 KSKVTLSSLMEELVLKSNYTDSFFEFQVVEGPPRFIKGISDCYAPIGTAAYFQCLVRGSP 5541
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTA 1259
P YW KD + + R ++ + TG+ L I KSD G Y A N++G+ A
Sbjct: 5542 RPTVYWYKDGKLV--QGRRFTVEESGTGFHNLFITSLVKSDEGEYRCVATNKSGMAESFA 5599
Query: 1260 RLDI 1263
L +
Sbjct: 5600 ALTL 5603
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/385 (25%), Positives = 159/385 (41%), Gaps = 73/385 (18%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GT 1001
+ P+F ++LK+ + EGS + + G P P + W K+ I +++ K+R EG G
Sbjct: 1554 VKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS-DIIVPHKYPKIRIEGTKGE 1612
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRIS--CSGHLMVQSL---PIRSRLTSAGQSHRGRS 1056
+L I+ST S D YT A N GR + C ++ V+ P R + G ++R +
Sbjct: 1613 AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRG-TYRAKE 1671
Query: 1057 RVQERDKEPLQERFFRPHFLQAPGDMVAHEG-------------RLCRL-----DCKVSG 1098
+ + EPL R+ + + + GD+ E RL R +C+++
Sbjct: 1672 -IAAPELEPLHLRYGQEQWEE--GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTP 1728
Query: 1099 LPPPELT--WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNS 1156
+ P + WL +G+P L A+ ++ E G SL RD+G C ATNK G +
Sbjct: 1729 IGDPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDH 1787
Query: 1157 FSLELSV--------------------------------------VAKEVKKAPVILEKL 1178
S L V ++ K+ P I+
Sbjct: 1788 TSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYP 1847
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ V EG R CRV G P P W + + I ++ R + D Y L I K
Sbjct: 1848 EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK-RFRVRYDGIHY--LDIVDCKS 1904
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDI 1263
D G ++A+N G++ +L+I
Sbjct: 1905 YDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 84.7 bits (208), Expect = 5e-16
Identities = 67/235 (28%), Positives = 97/235 (41%), Gaps = 16/235 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKI--VGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
P F K+L R+ P F C++ +G P V W DGK + N +M E G C
Sbjct: 1703 PFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANR-LRMINEF-GYC 1760
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL S D G T A N G S L+V+ + + +G R++E +
Sbjct: 1761 SLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELE 1820
Query: 1063 KEPL----------QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ Q+ +P + P + EG R C+V+G P P++ W LNGQ
Sbjct: 1821 RMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ- 1879
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
L S + VR G+H L I D G K A N G ++L + +E
Sbjct: 1880 -LIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRE 1933
Score = 84.3 bits (207), Expect = 7e-16
Identities = 76/282 (26%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 261 YEEPLGQPPRFTQKLRSREVPEGTRVQLDCIV--VGIPPPQVRWYCEGKELENSPDIHIV 318
Y++ Q P F +KL S + +C + +G P V W +GK LE + + ++
Sbjct: 1695 YDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI 1754
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--SDSEGDPNKEEMN 376
SL A+ D+G +C A+N YGTD TSA + ++ S +S+ ++ +
Sbjct: 1755 NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQ 1814
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ-QCQSPTNYLQGLDGKPIIAAP 435
RI++ + + H A V T Q + Q P I+ P
Sbjct: 1815 RIEE-----------------LERMAHEGALTGVTTDQKEKQKP----------DIVLYP 1847
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
++L EG+ F CRV G P PKV WY G LI S FR+ +
Sbjct: 1848 EPVRVL------EGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV---------RYD 1892
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
I L I + + D+G TA N G + +L ++ ED
Sbjct: 1893 GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRED 1934
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/120 (39%), Positives = 64/120 (53%), Gaps = 8/120 (6%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
+ P L+N++ EG+ V EC + G PSP V WYRE IE S DF+I +
Sbjct: 940 VTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ----- 994
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTT 551
I L+I E FAEDSG FTC+A N+ GTVS+ L V+ +E+ + + TT
Sbjct: 995 ---SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTT 1051
Score = 79.0 bits (193), Expect = 3e-14
Identities = 93/374 (24%), Positives = 153/374 (40%), Gaps = 67/374 (17%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
A P F + LQ+++ +G V + RV G P+P V++YR+G I+ S DF+I Q+
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQE------ 155
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED--------LSNNGSL 544
++ +L+IAE + EDSG ++ A+N G +S A+L V+G E+ + + +
Sbjct: 156 --GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213
Query: 545 HSANST------------TNLAAIE------PQPSPPHSEPPSVEQPPKPKLE-----GV 581
+ T ++A +E PH PP + PPKPK +
Sbjct: 214 SESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRI--PPKPKSRSPTPPSI 271
Query: 582 LVNHNEPRSSSRIGLR------VHFNLPEDDKGSEASSEAGVVTT--RQTRPDSFQERFN 633
R S +R H P S A + T+ R R +
Sbjct: 272 AAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQ 331
Query: 634 GQATKT-PEPSSPVKEPPPVLAKPKLDS-----TQLQQLHNQVLLE-QHQLQNPPP-SSP 685
T PE P K+ V + + + T Q+ + E ++ +Q S
Sbjct: 332 ASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGA 391
Query: 686 KEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVF 745
S++ S A AV T +K+VK + ++ ++A T A +A PV
Sbjct: 392 AGAAASVSASASYAAEAVATGAKEVKQDADKSAAVA--------TVVAAVDMARVREPV- 442
Query: 746 TLSSTPQTIQRTVS 759
+S+ QT QRT +
Sbjct: 443 -ISAVEQTAQRTTT 455
Score = 78.2 bits (191), Expect = 5e-14
Identities = 63/231 (27%), Positives = 93/231 (40%), Gaps = 16/231 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P LK+ V EG VT C I G P P V W+++ QI + G L
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDF--QITFQSGIARL 1000
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ--------SLPIRSRLTSAGQSHRGRS 1056
I ++D G +T A N G +S S +L VQ + + + T+ +
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060
Query: 1057 RVQERDKEPLQERF-----FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQ 1111
V D +E+ P+F+ P EG C+V G P P + W +G
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120
Query: 1112 PVLPDASHKMLV-RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P+ +K+ ++TG L+I DAG Y + NK G+ S S L
Sbjct: 1121 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 78.2 bits (191), Expect = 5e-14
Identities = 63/248 (25%), Positives = 108/248 (43%), Gaps = 42/248 (16%)
Query: 957 TEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGN 1016
+EG P F C++ G + KV W+ K+I K + +M + D T L I +D+G
Sbjct: 3357 SEGQPARFQCRVSGTDL-KVSWYSKDKKI-KPSRFFRMTQFED-TYQLEIAEAYPEDEGT 3413
Query: 1017 YTIMAANPQGRISCSGHLMV------------QSLPIRSR-LTSAGQSHRGRSRVQER-- 1061
YT +A+N G++S + +L + Q + + + L S G+S ++
Sbjct: 3414 YTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELFSEGESEHSERDTRDAFS 3473
Query: 1062 DKEPLQER-------------------FFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPP 1102
D E + + +F+P F Q EG C++ P P
Sbjct: 3474 DSEDIDHKSMAAKRYASRISSTSSWPEYFKPSFTQKLTFKYVLEGEPVVFTCRLIACPTP 3533
Query: 1103 ELTWLLNGQPVLPDASHKMLVRETGVH----SLLIDPLTQRDAGTYKCIATNKTGQNSFS 1158
E+TW N +P+ P +++ E+ +H SL I + RD+G+Y+ +A N G +
Sbjct: 3534 EMTWFHNNRPI-PTGLRRIIKAESDLHHHSSSLEIKRVQDRDSGSYRLLAINSEGSAEST 3592
Query: 1159 LELSVVAK 1166
L V+ K
Sbjct: 3593 ASLLVIQK 3600
Score = 77.8 bits (190), Expect = 6e-14
Identities = 70/281 (24%), Positives = 114/281 (40%), Gaps = 35/281 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSL 326
P F +KL++ + EG+R+++ G P P + W + P I I +L
Sbjct: 1556 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1615
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I +D+ Y+ A N G D+T ++ +E V ++ E
Sbjct: 1616 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE-VEFAEPE------------------- 1655
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-LDGKPIIAAPVFTKMLQNLS 445
P +IP +A+ + A P + + + +G L K P F K L +L
Sbjct: 1656 -PERKLIIPRGTYRAKEIAA-PELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1713
Query: 446 ASEGQLVVFECRVK--GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
FECR+ G P+ VEW +G +E + R++ + C+L
Sbjct: 1714 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFG--------YCSLDYG 1765
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSL 544
++ DSG TC A+NKYGT + A L V+ + L L
Sbjct: 1766 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQL 1806
Score = 76.6 bits (187), Expect = 1e-13
Identities = 72/269 (26%), Positives = 108/269 (40%), Gaps = 19/269 (7%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L+ EG + C V G +V WY + K+++ S + Q + + L
Sbjct: 3344 PPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLE 3402
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNR----IQKPNE 383
IAEA+ ED G Y+ ASN G S++A + +E S E + EM + +E
Sbjct: 3403 IAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELFSEGESE 3462
Query: 384 VSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQN 443
S T A + + A+ + I S Y + P FT+ L
Sbjct: 3463 HSERDTRDAFSDSEDIDHKSMAAKRYASRISSTSSWPEYFK----------PSFTQKLTF 3512
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
EG+ VVF CR+ P+P++ W+ I R + K + +L I
Sbjct: 3513 KYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTG--LRRIIKAESDLHHHSS--SLEIK 3568
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
V DSG + A N G+ S A L V
Sbjct: 3569 RVQDRDSGSYRLLAINSEGSAESTASLLV 3597
Score = 73.9 bits (180), Expect = 9e-13
Identities = 74/287 (25%), Positives = 110/287 (38%), Gaps = 40/287 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F + L R+V E T + V G+P P V+WY LE I + + GN+ SL
Sbjct: 5182 PPSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLEPDERIKMERVGNVCSLE 5241
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYI----EGVSSSD--------SEGDPNKEEM 375
I+ + + G Y C A NI G + A + I E V + E D
Sbjct: 5242 ISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEERVVALPPPVTHQHVMEFDLEHTTS 5301
Query: 376 NRIQKPNEVSSPPTTS-------------AVIPPAVPQAQHLVAQPRVATIQQCQSPTNY 422
+R P E+ S +P P + ++ V +
Sbjct: 5302 SRTPSPQEIVLEVELSEKDVKEFEKQVKIVTVPEFTPDHKSMIVSLDVLPFNFVDPNMDS 5361
Query: 423 LQG------LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIE 476
+G +D + P F + + E VF+C V G P+P+V+WY+E IE
Sbjct: 5362 REGEDKELKIDLEVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIE 5421
Query: 477 -DSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
D+ + I ++K TL I V DS + C A N G
Sbjct: 5422 PDNIKYVISEEKGSH--------TLKIRNVCLSDSATYRCRAVNCVG 5460
Score = 73.2 bits (178), Expect = 2e-12
Identities = 68/270 (25%), Positives = 107/270 (39%), Gaps = 44/270 (16%)
Query: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAG 321
E PPRF + ++PE + C V+GIP P+V+WY E +E +++ +
Sbjct: 5374 EVFEMPPRFIMPICDFKIPENSDAVFKCSVIGIPTPEVKWYKEYMCIEPDNIKYVISEEK 5433
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP 381
H+L I D+ Y C A N G E G + GD E I K
Sbjct: 5434 GSHTLKIRNVCLSDSATYRCRAVNCVG------EAICRGFLTM---GD--SEIFAVIAKK 5482
Query: 382 NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-LDGKPIIAAPVFTKM 440
++V T S+++ V + +NY + + + P F K
Sbjct: 5483 SKV----TLSSLMEELVLK-------------------SNYTDSFFEFQVVEGPPRFIKG 5519
Query: 441 LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTL 500
+ + A G F+C V+G+P P V WY++G L++ ++ L
Sbjct: 5520 ISDCYAPIGTAAYFQCLVRGSPRPTVYWYKDGKLVQG--------RRFTVEESGTGFHNL 5571
Query: 501 VIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
I + D G + C A+NK G S A L
Sbjct: 5572 FITSLVKSDEGEYRCVATNKSGMAESFAAL 5601
Score = 68.6 bits (166), Expect = 4e-11
Identities = 76/309 (24%), Positives = 132/309 (42%), Gaps = 42/309 (13%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S ++LY E + F + ++ +V E R +C V P V+W + +EL+ +
Sbjct: 3046 TSTATLYVE---ARHIEFRKHIKDIKVLEKKRAMFEC-EVSEPDITVQWMKDDQELQITD 3101
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
I I + +H L I D G+Y+ A G + ++A++++EG D K+
Sbjct: 3102 RIKIQKEKYVHRLLIPSTRMSDAGKYTVVA----GGNVSTAKLFVEG---RDVRIRSIKK 3154
Query: 374 EMNRIQKPNEVSSPPTTSAVIPP-----------AVPQAQHLVAQPRV------ATIQQC 416
E+ I+K V + V + V + R+ T Q
Sbjct: 3155 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSD 3214
Query: 417 QSPTNYLQGLDGKPI---IAAPVFTKMLQNL---SASEGQLVVFECRVKGAPSPKVEWYR 470
++ G + + + AP ++LQ L + G+ F + G P PK+ WY+
Sbjct: 3215 AGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYK 3274
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
E L+ S F K + + + +E TL++ E F ED+ +TC A N YG ++ A L
Sbjct: 3275 EEQLL--STGF-----KCKFLHDGQEY-TLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3326
Query: 531 HVRGNEDLS 539
V E +S
Sbjct: 3327 SVEVPEVVS 3335
Score = 66.6 bits (161), Expect = 1e-10
Identities = 86/381 (22%), Positives = 144/381 (37%), Gaps = 77/381 (20%)
Query: 697 SNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQR 756
S A A+ T K++ A SS K + T P+ P F + TP T +
Sbjct: 833 SIAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYK- 891
Query: 757 TVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIP 816
S V+ K G+SI T T F + G + +
Sbjct: 892 ---------SEAGVEVKKEVGVSI---------TGTTVREERFEVLHGREAK-------- 925
Query: 817 VSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPR------------------SAPSMP-- 856
V+ T+R+ PV +P PPT GL +P++
Sbjct: 926 VTETARVPAPV--------EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 977
Query: 857 ----------------SQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT--FSDVRP 898
G+A+ + + +D+ R T +AV + G T + V+
Sbjct: 978 REDYQIESSIDFQITFQSGIARLMIR--EAFAEDSGRFTCSAV-NEAGTVSTSCYLAVQV 1034
Query: 899 NQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVT 957
+++ E + ++ ++ E + +E V +D + ++ G+ AP F + ++
Sbjct: 1035 SEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV 1094
Query: 958 EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
EG V F C++ G P P VYW K G ++ + + G C L I T +DD G Y
Sbjct: 1095 EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEY 1154
Query: 1018 TIMAANPQGRISCSGHLMVQS 1038
TI+ N G S S L+ ++
Sbjct: 1155 TIVVRNKHGETSASASLLEEA 1175
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 1052 HRGRSRVQE--RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
H ++V E R P++ P + ++ EG L+C +SG P P +TW
Sbjct: 920 HGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRE 979
Query: 1110 GQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEV 1168
+ ++ ++G+ L+I D+G + C A N+ G S S L+V V++E
Sbjct: 980 DYQIESSIDFQITF-QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF 1038
Query: 1169 KK----------------------------------------APVILEKLQNCGVPEGHP 1188
+K AP + K + EG
Sbjct: 1039 EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGS 1098
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCT---RERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
V C+V G P P YWKK +P T R ++S ++ TG L+I DAG YT
Sbjct: 1099 VVFGCQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQ-TGECKLVISMTFADDAGEYT 1155
Query: 1246 LSAKNEAGIVSCTARL 1261
+ +N+ G S +A L
Sbjct: 1156 IVVRNKHGETSASASL 1171
Score = 64.7 bits (156), Expect = 6e-10
Identities = 62/220 (28%), Positives = 89/220 (40%), Gaps = 26/220 (11%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
+ L+ V G P F I G P PK+ W+K+ +Q+ CK +G L IE+
Sbjct: 3243 QELQPVTVQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEA 3301
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
+D YT A N G + S L V+ + S P QE
Sbjct: 3302 FP-EDAAVYTCEAKNDYGVATTSASLSVEVPEVVS---------------------PDQE 3339
Query: 1069 RFFRPHFLQAP-GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P + P D V EG+ R C+VSG +++W + + P +M E
Sbjct: 3340 MPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFED- 3397
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
+ L I D GTY +A+N GQ S + LS+ A E
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPE 3437
Score = 63.5 bits (153), Expect = 1e-09
Identities = 62/255 (24%), Positives = 104/255 (40%), Gaps = 44/255 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP +R++ V +GS F ++VG P P+ W+K+G +I +R++ D C
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI-ERSDRIYWYWPEDNVCE 2135
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I T++D + + A N G S L+VQ+ + +
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLIT-------------------- 2175
Query: 1064 EPLQERFFRPHFLQAPGDMVAHE-GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F Q D+VA E + +C+ S P ++ W +G V ++M
Sbjct: 2176 -----------FTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDGMEVHEGDKYRM- 2222
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQN 1180
+ VH L I + DA Y C+ + AK + + V+ +++LQ+
Sbjct: 2223 HSDRKVHFLSILTIDTSDAEDYSCVLVEDE-------NVKTTAKLIVEGAVVEFVKELQD 2275
Query: 1181 CGVPEGHPVRLECRV 1195
VPE + LEC V
Sbjct: 2276 IEVPESYSGELECIV 2290
Score = 60.8 bits (146), Expect = 8e-09
Identities = 81/357 (22%), Positives = 127/357 (35%), Gaps = 67/357 (18%)
Query: 266 GQP--PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV---QA 320
G+P P F K +++ EG V C V G P P V W G L + Q
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQT 1136
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG----VSSSDSEGDPNKEEMN 376
G L I+ F +D G Y+ N +G S SA + E + S E +
Sbjct: 1137 GEC-KLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTA 1195
Query: 377 RIQKPNEVSSPP-----------------------TTSAVIPPAVPQAQHLVAQPRVATI 413
+Q+P + P + V+ V + ++ I
Sbjct: 1196 FVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLI 1255
Query: 414 QQCQ-----SPTNYLQGLDGKPIIAAPV---------FTKMLQNLSASEGQLVVFECRVK 459
++ + + L DG+ +A + F ++N EG V F C++
Sbjct: 1256 KEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMS 1315
Query: 460 GAPSPKVEWYREGTLIEDSPDFRI--LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
G P PK+ WY++G I+ +++ LQ S+ P V ED G +T A
Sbjct: 1316 GYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIP---------VVLPEDEGIYTAFA 1366
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
SN G +L+V L + T + +EP P SV + P
Sbjct: 1367 SNIKGNAICSGKLYVEPAAPL---------GAPTYIPTLEPVSRIRSLSPRSVSRSP 1414
Score = 60.8 bits (146), Expect = 8e-09
Identities = 85/347 (24%), Positives = 134/347 (38%), Gaps = 61/347 (17%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
RV EG F C++ G P PKV W+ +G+ I K + R DG L I S D
Sbjct: 1851 RVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK---RFRVRYDGIHYLDIVDCKSYDT 1907
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G + A NP+G I L +Q Q RS V R EP RP
Sbjct: 1908 GEVKVTAENPEGVIEHKVKLEIQ------------QREDFRS-VLRRAPEP------RPE 1948
Query: 1075 F-LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV----LPDASHKMLVR----- 1124
F + PG + + + ++D V E+ L + + +P+ S ++ +
Sbjct: 1949 FHVHEPGKL---QFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRT 2005
Query: 1125 ETGVHSLLID---PLTQRDAGTYKCIATNKTGQNSFSLELS-----VVAKEVK------- 1169
E G + + ++D + + K ++ EL+ +A+E K
Sbjct: 2006 EEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFK 2065
Query: 1170 ----------KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+AP I E++Q+ V +G RV+G P P W K+ I +RI
Sbjct: 2066 PDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRI 2124
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ L+I+ D+ + A N AG S A L + A+
Sbjct: 2125 YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2171
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT ++ P + AP + +Q+ + +G F RV G P P+ EWY+ G IE S
Sbjct: 2062 PTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERS 2121
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
RI P + +C LVI +V AEDS A N G SS A L V+ + +
Sbjct: 2122 D--RIYWYWPE-----DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLI 2174
Query: 539 SNNGSLHS--ANSTTNLAAIEPQPSPP 563
+ L A +A E + S P
Sbjct: 2175 TFTQELQDVVAKEKDTMATFECETSEP 2201
Score = 57.8 bits (138), Expect = 7e-08
Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F +RL+ V +GS V ++ GIP P V +++DG +I + ++ +EGD SL
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDF-QISQEGD-LYSL 161
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ---SLPIRSRLTSAGQSHRGRSRVQER 1061
I +D G Y++ A N GR + + L+VQ +P + T + SR Q R
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESR-QTR 220
Query: 1062 DKEPLQERF 1070
++ ++ F
Sbjct: 221 IEKKIEAHF 229
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 2/95 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENS--PDIHIVQAGNLH 324
Q P FTQ L+S V EG+ + + G P P+V W+ +G+ + S P + I +
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
LTI + ++GRYS A+N G +++AE+ ++
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98
Score = 55.1 bits (131), Expect = 4e-07
Identities = 64/280 (22%), Positives = 107/280 (38%), Gaps = 33/280 (11%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T+ +++ EVPE +C V P + W G E+E S IV G LH L I
Sbjct: 2885 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNT 2943
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
ED+ Y+ + G D SA + + + + D N EE + I V+ +
Sbjct: 2944 STEDSAEYTF----VCGNDQVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISY 2999
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-------LDGKPIIAAPV-------- 436
+ V Q R + + N G + GK A +
Sbjct: 3000 KWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIE 3059
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
F K ++++ E + +FEC V P V+W ++ ++ + +I ++K
Sbjct: 3060 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEK--------Y 3110
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ L+I D+G +T A T A+L V G +
Sbjct: 3111 VHRLLIPSTRMSDAGKYTVVAGGNVST----AKLFVEGRD 3146
Score = 55.1 bits (131), Expect = 4e-07
Identities = 35/130 (26%), Positives = 61/130 (46%), Gaps = 8/130 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD---GT 1001
P F ++L V EG PV FTC+++ P P++ WF + + I ++ E D +
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRI-IKAESDLHHHS 3562
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMV----QSLPIRSRLTSAGQSHRGRSR 1057
SL I+ D G+Y ++A N +G + L+V Q L A ++H
Sbjct: 3563 SSLEIKRVQDRDSGSYRLLAINSEGSAESTASLLVIQKGQDEKYLEFLKRAERTHENVEA 3622
Query: 1058 VQERDKEPLQ 1067
+ ER ++ ++
Sbjct: 3623 LVERGEDRIK 3632
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACL 1231
P ++ L+N V EG V LEC + G P P W +++ I + + Q +G A L
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ--SGIARL 1000
Query: 1232 LIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+I+ A D+G +T SA NEAG VS + L +
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 54.3 bits (129), Expect = 8e-07
Identities = 78/382 (20%), Positives = 141/382 (36%), Gaps = 55/382 (14%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS--PDFRILQKKPRSM 491
AP FT+ LQ++ EG FE + G P P+V W+R+G +I S P +I R+
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA- 63
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN------NGSLH 545
L I V +SG ++ A+N G +S A+L V+ N + ++
Sbjct: 64 -------KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVR 116
Query: 546 SANSTTNLAAIEPQPSPP---HSEPPSVEQ------PPKPKLEGVLVNHNEPRSSSRIGL 596
+ + P+P + + ++ + L +L+ P S +
Sbjct: 117 QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 597 RVHFNLPEDDKGSE----------------ASSEAGVVTTRQTRPD-SFQERFNGQATKT 639
++ +E S A + +RQTR + + F+ ++ T
Sbjct: 177 NATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT 236
Query: 640 PE--------PSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFS 691
E P K PP + KPK S + + L + Q PS + P
Sbjct: 237 VEMVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQ----SPSPIRHSPSP 292
Query: 692 MTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTP 751
+ + + P V + S + +S S+ P + +T AT P P +
Sbjct: 293 VRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVAT-GPEVPPPWKQEGYV 351
Query: 752 QTIQRTVSKESLLVSHPSVQTK 773
+ +E+ L + ++T+
Sbjct: 352 ASSSEAEMRETTLTTSTQIRTE 373
Score = 53.9 bits (128), Expect = 1e-06
Identities = 58/245 (23%), Positives = 92/245 (37%), Gaps = 41/245 (16%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+P P F + +++ EG F C +G P P V WY I + +F I
Sbjct: 3938 RPQRCPPSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFII----- 3992
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSA- 547
E L ++ V ++ G TC N+YGTV + + L V+ + ++ H
Sbjct: 3993 ---HSLENYSILTLSSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAKQ--KHDVKAHKVP 4047
Query: 548 ------NSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSS--------R 593
+ LA + Q H PS+ Q + L + N P S
Sbjct: 4048 VFHDYLDEEEELALVFDQAKGAH---PSMSQEGQTNLHLLKTNPPVPPSGDTELLSFPVE 4104
Query: 594 IGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEP-----SSPVKE 648
I + +PE DK S+ V T + P + + Q T++P+ S E
Sbjct: 4105 IQVTAATPIPEQDKESKE-----VFQTEELEPKAMPQ---DQVTQSPKHRFVFLSDITNE 4156
Query: 649 PPPVL 653
PP +L
Sbjct: 4157 PPKML 4161
Score = 52.8 bits (125), Expect = 2e-06
Identities = 39/130 (30%), Positives = 59/130 (45%), Gaps = 7/130 (5%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
KH R EG + C I G P P V WF++G + K+N+ + E + + L+I+ S
Sbjct: 4166 KHARCREGDSIILECLISGEPQPVVTWFQNG-VLLKQNQKFQF-EEVNCSHQLYIKDVNS 4223
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIR--SRLTSAGQSHRGRSRVQERDKEPLQER 1069
D G Y +A N G + L V+ + R S+ + G+ + SR Q+ Q
Sbjct: 4224 QDSGKYKCVAENNSGAVESVSDLTVEPVTYRENSQFENIGEIYGKYSRDQQLQD---QGE 4280
Query: 1070 FFRPHFLQAP 1079
R HF P
Sbjct: 4281 SVRAHFYDYP 4290
Score = 52.4 bits (124), Expect = 3e-06
Identities = 71/307 (23%), Positives = 109/307 (35%), Gaps = 63/307 (20%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K LK+ VTE FT ++ V V W K+G + + NE + +G SL I++
Sbjct: 2711 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGV-VLESNEKYAISVKGT-IYSLRIKN 2768
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
D+ Y GR+ S L V+++ I
Sbjct: 2769 CAIVDESVYGFRL----GRLGASARLHVETVKI--------------------------- 2797
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ P D+ A E + VS P + W + P H+ LV E V
Sbjct: 2798 -------IKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHR-LVSERKV 2848
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
H L++ ++ DAG Y + GQ +L V + K ++N VPE
Sbjct: 2849 HKLMLQNISPSDAGEYTAV----VGQLECKAKLFVETLHITKT------MKNIEVPETKT 2898
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQPAKKSDAGWY 1244
EC V P + K E + +I +HQ L+I D+ Y
Sbjct: 2899 ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQ-------LIIMNTSTEDSAEY 2951
Query: 1245 TLSAKNE 1251
T N+
Sbjct: 2952 TFVCGND 2958
Score = 51.6 bits (122), Expect = 5e-06
Identities = 49/181 (27%), Positives = 73/181 (40%), Gaps = 29/181 (16%)
Query: 1008 STTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG----QSHRGRSRVQERDK 1063
S + + N ++ NP + SG + S P+ ++T+A Q + Q +
Sbjct: 4072 SMSQEGQTNLHLLKTNPP--VPPSGDTELLSFPVEIQVTAATPIPEQDKESKEVFQTEEL 4129
Query: 1064 EPL-----------QERFF--------RPHFLQA-PGDMVAHEGRLCRLDCKVSGLPPPE 1103
EP + RF P LQ P EG L+C +SG P P
Sbjct: 4130 EPKAMPQDQVTQSPKHRFVFLSDITNEPPKMLQEMPKHARCREGDSIILECLISGEPQPV 4189
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGV-HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELS 1162
+TW NG VL + K E H L I + +D+G YKC+A N +G +L+
Sbjct: 4190 VTWFQNG--VLLKQNQKFQFEEVNCSHQLYIKDVNSQDSGKYKCVAENNSGAVESVSDLT 4247
Query: 1163 V 1163
V
Sbjct: 4248 V 4248
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/295 (24%), Positives = 113/295 (38%), Gaps = 55/295 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDD 1013
+V EG V K+ V V W KDG+++ + H + ++ L IE T +D
Sbjct: 2366 KVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRVHIVIDKQSH---MLLIEDMTKED 2421
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
GNY+ P +S SG + V S+ + + L
Sbjct: 2422 AGNYSFTI--PALGLSTSGRVSVYSVDVITPLK--------------------------- 2452
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
D+ EG L+CKVS + W LN + + PD + +V+ T L+I
Sbjct: 2453 -------DVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT-KQRLVI 2504
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ D G YK I G+ + LSV +++K I+ L++ E V E
Sbjct: 2505 NRTHASDEGPYKLI----VGRVETNCNLSV--EKIK----IIRGLRDLTCTETQNVVFEV 2554
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+ V + KD E P ++ +I H L + K D G YT A
Sbjct: 2555 ELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYK---LTVLNMMKDDEGKYTFYA 2606
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 54/300 (18%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K +K+ V E +F C++ VP + W K+G +I + +E K+ +G L I +
Sbjct: 2886 KTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEI-EMSEKFKIVVQGK-LHQLIIMN 2942
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
T+++D YT + N Q S L V + I S L +E+D +
Sbjct: 2943 TSTEDSAEYTFVCGNDQ----VSATLTVTPIMITSMLKDI--------NAEEKDTITFEV 2990
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
V +EG WL NG + +M ++
Sbjct: 2991 -------------TVNYEG--------------ISYKWLKNGVEIKSTDKCQMRTKKL-T 3022
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
HSL I + DA Y +A G+ + + L V A+ ++ + +++ V E
Sbjct: 3023 HSLNIRNVHFGDAADYTFVA----GKATSTATLYVEARHIE----FRKHIKDIKVLEKKR 3074
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
EC V P W KD++ + T +RI + ++ + LLI + SDAG YT+ A
Sbjct: 3075 AMFECEV-SEPDITVQWMKDDQELQIT-DRIKIQKEKYVHR-LLIPSTRMSDAGKYTVVA 3131
Score = 48.9 bits (115), Expect = 3e-05
Identities = 42/185 (22%), Positives = 74/185 (40%), Gaps = 13/185 (7%)
Query: 187 SQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRR---------- 236
+ KV +E+ S R E + + + + + E+ K +
Sbjct: 1986 THEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKEL 2045
Query: 237 -EAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
E E+ A G T P P + P + P+ ++++S+ V +G+ VVG
Sbjct: 2046 TEEEKKALAEEGKITIPTFKPDKIELS-PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGK 2104
Query: 296 PPPQVRWYCEGKELENSPDIH-IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P+ WY G ++E S I+ N+ L I + ED+ A NI G S+ A
Sbjct: 2105 PDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHA 2164
Query: 355 EIYIE 359
+ ++
Sbjct: 2165 FLLVQ 2169
Score = 48.1 bits (113), Expect = 5e-05
Identities = 65/338 (19%), Positives = 113/338 (33%), Gaps = 52/338 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F + ++ V EG F C G P P V W+ + I + E +L
Sbjct: 3944 PSFLQEIESQEVYEGDSCNFVCHFQGYPQPIVTWYNNDMPIPRNQNFIIHSLENYSILTL 4003
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
S ++G+ T + N G + + L V++
Sbjct: 4004 --SSVHHQNEGSITCVLFNQYGTVKTTSMLKVKAK------------------------- 4036
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPP-------ELTWLLNGQPVLPDA 1117
Q+ + H + D + E L + + G P L L PV P
Sbjct: 4037 --QKHDVKAHKVPVFHDYLDEEEELALVFDQAKGAHPSMSQEGQTNLHLLKTNPPVPPSG 4094
Query: 1118 SHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLE------------LSVVA 1165
++L + P+ ++D + + T + + + LS +
Sbjct: 4095 DTELLSFPVEIQVTAATPIPEQDKESKEVFQTEELEPKAMPQDQVTQSPKHRFVFLSDIT 4154
Query: 1166 KEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDT 1225
E K + K C EG + LEC + G P PV W + N + ++ +
Sbjct: 4155 NEPPKMLQEMPKHARCR--EGDSIILECLISGEPQPVVTWFQ-NGVLLKQNQKFQFEEVN 4211
Query: 1226 TGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+ L I+ D+G Y A+N +G V + L +
Sbjct: 4212 CSHQ-LYIKDVNSQDSGKYKCVAENNSGAVESVSDLTV 4248
Score = 47.8 bits (112), Expect = 7e-05
Identities = 61/274 (22%), Positives = 105/274 (38%), Gaps = 66/274 (24%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVY----------------WFKDGKQISKRNEHCKMRREGD 999
+ EG+ V F ++ I VP+ Y W+ + ++ ++ R G
Sbjct: 2261 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGR 2320
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+L ++ T +D G Y+ + + +C L ++ PI
Sbjct: 2321 Q--NLTVKDVTKEDQGEYSFVIDGK--KTTCK--LKMKPRPIA----------------- 2357
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP-DAS 1118
LQ D EG + +L+ KVS L E W+ +GQ V P D
Sbjct: 2358 ---------------ILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRV 2401
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
H ++ +++ H LLI+ +T+ DAG Y +L LS + + ++ L
Sbjct: 2402 HIVIDKQS--HMLLIEDMTKEDAGNYSFTIP--------ALGLSTSGRVSVYSVDVITPL 2451
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
++ V EG LEC+V W ++E I
Sbjct: 2452 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI 2485
Score = 47.8 bits (112), Expect = 7e-05
Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 8/103 (7%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F + L E + F V+G P P V+WYR +L+E PD RI M
Sbjct: 5183 PSFIEPLTKRKVYENTTLGFIVEVEGLPVPGVKWYRNKSLLE--PDERI------KMERV 5234
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
+C+L I+ + + G + C A N G S A + + E+
Sbjct: 5235 GNVCSLEISNIQKGEGGEYMCHAVNIIGEAKSFANVDIMPQEE 5277
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/137 (25%), Positives = 50/137 (36%), Gaps = 14/137 (10%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E L++ E R A + A D P + Y EP+ V E
Sbjct: 1808 EGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPV-------------RVLE 1854
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G + C V G P P+V WY G+ + S + G +H L I + DTG
Sbjct: 1855 GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IHYLDIVDCKSYDTGEVKVT 1913
Query: 343 ASNIYGTDSTSAEIYIE 359
A N G ++ I+
Sbjct: 1914 AENPEGVIEHKVKLEIQ 1930
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/97 (29%), Positives = 45/97 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP + LQ+ V EG E + G P P W +D + I + + G A
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
L I K+++G Y+L A N +G + TA L + A+
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE 100
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P Q L ++V EG VQL+ + V + + W +G+E++ S +HIV H L
Sbjct: 2354 RPIAILQGLSDQKVCEGDIVQLE-VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2412
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I + +ED G YS F G STS + + V D N E + +VS
Sbjct: 2413 LIEDMTKEDAGNYS-FTIPALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSV 2470
Query: 387 PPTTS 391
P TS
Sbjct: 2471 PDVTS 2475
Score = 44.3 bits (103), Expect = 8e-04
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSLT 327
P F K S + EG + D VVG P P+ W+ +G+++ N +V + SL
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
I A D+G ++ A N G S S + +E V
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1550
Score = 44.3 bits (103), Expect = 8e-04
Identities = 31/92 (33%), Positives = 40/92 (43%), Gaps = 2/92 (2%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY--A 1229
P +KL V EG PV CR+I P P W +N IP RI + + +
Sbjct: 3504 PSFTQKLTFKYVLEGEPVVFTCRLIACPTPEMTWFHNNRPIPTGLRRIIKAESDLHHHSS 3563
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
L I+ + D+G Y L A N G TA L
Sbjct: 3564 SLEIKRVQDRDSGSYRLLAINSEGSAESTASL 3595
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/201 (21%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
V W + KE++ S I G ++ LT+ ++D G+Y+ +A G + TS ++ +
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYA----GENMTSGKLTVA 2618
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSP-------------PTTSAVIPPAVPQAQHL-V 405
G + S D E EV++P P T+ + + + L +
Sbjct: 2619 GGAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 2678
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
A ++ I + K + A K L+NL+ +E Q VF +
Sbjct: 2679 AATKLDDIGEYTYKV-ATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKG 2737
Query: 466 VEWYREGTLIEDSPDFRILQK 486
V+W + G ++E + + I K
Sbjct: 2738 VQWIKNGVVLESNEKYAISVK 2758
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/211 (22%), Positives = 78/211 (36%), Gaps = 18/211 (8%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V EGT+ L+C V V+WY ++++ + + G L I
Sbjct: 2451 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHAS 2510
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPT----- 389
D G Y I G T+ + +E + D E + E+S
Sbjct: 2511 DEGPYKL----IVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2566
Query: 390 -TSAVIPPAVP---QAQHLVAQPRVAT-IQQCQSPTNYLQG---LDGKPIIAAPVFTKML 441
I P+ +A + + V ++ + + G GK +A +K L
Sbjct: 2567 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPL 2626
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
+ + +E Q VFEC V P K EW R+G
Sbjct: 2627 TDQTVAESQEAVFECEVAN-PDSKGEWLRDG 2656
Score = 40.4 bits (93), Expect = 0.011
Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 26/236 (11%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV--RWYCEGKELENSPDIHIVQAGNL 323
G F ++L+ EVPE +L+CIV P + +WY EL+++ I
Sbjct: 2264 GAVVEFVKELQDIEVPESYSGELECIV---SPENIEGKWYHNDVELKSNGKYTITSRRGR 2320
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAE----IYIEGVSSSD-SEGDPNKEEMN-- 376
+LT+ + +ED G YS T + ++G+S EGD + E+
Sbjct: 2321 QNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVS 2380
Query: 377 -------RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--D 427
++ EV VI Q+ L+ + S T GL
Sbjct: 2381 LESVEGVWMKDGQEVQPSDRVHIVID---KQSHMLLIEDMTKEDAGNYSFTIPALGLSTS 2437
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
G+ + + L++++ EG V EC+V V+WY I+ PD R+
Sbjct: 2438 GRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIK--PDDRV 2491
Score = 38.9 bits (89), Expect = 0.033
Identities = 62/298 (20%), Positives = 114/298 (38%), Gaps = 61/298 (20%)
Query: 951 LKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
LK V EG+ CK+ V V W+ + +QI K ++ + +G L I T
Sbjct: 2451 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI-KPDDRVQAIVKGTKQ-RLVINRTH 2508
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
+ D+G Y ++ GR+ + +L V+ + I
Sbjct: 2509 ASDEGPYKLIV----GRVETNCNLSVEKIKI----------------------------- 2535
Query: 1071 FRPHFLQAPGDMVAHEGR--LCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ D+ E + + ++ SG+ ++ W + + P + +K + +
Sbjct: 2536 -----IRGLRDLTCTETQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYK-IEAHGKI 2586
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
+ L + + + D G Y T G+N S +L+V + K L + V E
Sbjct: 2587 YKLTVLNMMKDDEGKY----TFYAGENMTSGKLTVAGGAISK------PLTDQTVAESQE 2636
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY-ACLLIQPAKKSDAGWYT 1245
EC V P W +D + +P T ++ ++ G+ L+I K D G YT
Sbjct: 2637 AVFECEVAN-PDSKGEWLRDGKHLPLTN---NIRSESDGHKRRLIIAATKLDDIGEYT 2690
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 11/99 (11%)
Query: 437 FTKMLQNLSASEGQ-LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
FT+ LQ++ A E + FEC P KV+WY++G + + +R+ S +
Sbjct: 2176 FTQELQDVVAKEKDTMATFECETS-EPFVKVKWYKDGMEVHEGDKYRM-----HSDRKVH 2229
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ L I AED C N V + A+L V G
Sbjct: 2230 FLSILTIDTSDAEDYSCVLVEDEN----VKTTAKLIVEG 2264
Score = 34.3 bits (77), Expect = 0.81
Identities = 67/299 (22%), Positives = 109/299 (36%), Gaps = 33/299 (11%)
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-GTRVQLDCIVVGIP 296
AE +AS G + S + Q FTQ+L+ E T +C P
Sbjct: 2143 AEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFEC-ETSEP 2201
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
+V+WY +G E+ + +H L+I D YSC T+A++
Sbjct: 2202 FVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENV-KTTAKL 2260
Query: 357 YIEGV------SSSDSE-GDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPR 409
+EG D E + E+ I P + + V ++ + R
Sbjct: 2261 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDV--ELKSNGKYTITSRR 2318
Query: 410 VATIQQCQSPTNYLQG-----LDGK----PIIAAPVFTKMLQNLS---ASEGQLVVFECR 457
+ T QG +DGK + P +LQ LS EG +V E +
Sbjct: 2319 GRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVK 2378
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
V S + W ++G ++ S I+ K M L+I ++ ED+G ++ T
Sbjct: 2379 V-SLESVEGVWMKDGQEVQPSDRVHIVIDKQSHM--------LLIEDMTKEDAGNYSFT 2428
Score = 33.1 bits (74), Expect = 1.8
Identities = 27/107 (25%), Positives = 38/107 (35%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
DK L P + +G +V G P PE W NG +
Sbjct: 2067 DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYW 2126
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV 1168
E V L+I +T D+ + A N G+ S L V AK++
Sbjct: 2127 YWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQL 2173
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
++ L + V E +C V P + W +GK L + +I G+ L IA
Sbjct: 2623 SKPLTDQTVAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAAT 2681
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
+D G Y+ + T TSA++ +E V
Sbjct: 2682 KLDDIGEYTYKVA----TSKTSAKLKVEAV 2707
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 223 bits (568), Expect = 9e-58
Identities = 144/450 (32%), Positives = 227/450 (50%), Gaps = 47/450 (10%)
Query: 878 ETKNAVIRD-LGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD- 935
E + A+IR + K QE+ ISSFE+RL+ EIE+R+ +T ++E +E +
Sbjct: 1219 EKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEK 1278
Query: 936 ---EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
+I + + FD R+K++R+ EG VTF CK+ G P+PK+ W+KDGK+I K E
Sbjct: 1279 MAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRI-KHGERY 1337
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL------------- 1039
+M DG SL I +D+G YT A+N +G CSG L V+
Sbjct: 1338 QMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLE 1397
Query: 1040 ----------------PIR--------SRLTSAGQSHRGRS---RVQERDKEPLQERFFR 1072
PIR +R++ A S S R++E D+ L ER ++
Sbjct: 1398 PVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL-ERLYK 1456
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F+ P EG+ R D KV G P PE W +GQ ++ D +HK++++E G SL+
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I P T D+G + +A N+ G++S S+ L+V A E + P+ +EKL+N + EG + ++
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1576
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
R G P P W K+++ I + + T G A L I D+ WYT +A N+A
Sbjct: 1577 VRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKA 1636
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS 1282
G + ++++ ++ P + P G+
Sbjct: 1637 GRDTTRCKVNVEVEFAEPEPERKLIIPRGT 1666
Score = 115 bits (288), Expect = 3e-25
Identities = 93/341 (27%), Positives = 143/341 (41%), Gaps = 45/341 (13%)
Query: 927 ESDDEIQHD----EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDG 982
E+ + I H+ EI AP+ ++++ V G FTC+I P + WFK G
Sbjct: 3434 EAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAG 3493
Query: 983 KQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIR 1042
++I + ++ C +R SL I T D G YT A+N G +SC+ L V
Sbjct: 3494 REIYE-SDKCSIR-SSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEA--- 3548
Query: 1043 SRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPP 1102
+ P FL P + G+ + C V+G P
Sbjct: 3549 ----------------------------YPPTFLSRPKSLTTFVGKAAKFICTVTGTPVI 3580
Query: 1103 ELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELS 1162
E W +G + P + ++ E H L + LT +D G Y C A+NK G + EL
Sbjct: 3581 ETIWQKDGAALSPSPNWRISDAENK-HILELSNLTIQDRGVYSCKASNKFGADICQAELI 3639
Query: 1163 VVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
++ K P +++L+ V LEC+V W KD + +P ++
Sbjct: 3640 IIDK-----PHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICF 3694
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+D A L I AK D+G Y +A NEAG SC+A + +
Sbjct: 3695 EDKI--ATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTV 3733
Score = 111 bits (277), Expect = 5e-24
Identities = 91/322 (28%), Positives = 141/322 (43%), Gaps = 17/322 (5%)
Query: 950 RLKHFRVTEGSPVTFTCKIVGIPVP-KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
++ H EG V + CKI +V W+ +Q+ + +E ++ E DG L+++
Sbjct: 31573 QIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQL-ENSEKYEITYE-DGVAILYVKD 31630
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER-DKEPLQ 1067
T DDG Y N G S L V+ + R R +++ R D L
Sbjct: 31631 ITKLDDGTYRCKVVNDYGEDSSYAELFVKGV----REVYDYYCRRTMKKIKRRTDTMRLL 31686
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET- 1126
ER P F + A+ G R ++ P P +TW +GQ + P + K E+
Sbjct: 31687 ER--PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 31744
Query: 1127 -GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNC 1181
G++ L I+ +T D Y +A NK G++S +L+V + P+ L N
Sbjct: 31745 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 31804
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
EG V E RV G+PPP W+KD + + +H+ YA L I+ D
Sbjct: 31805 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYA-LHIRDTLPEDT 31863
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G+Y ++A N AG SC A L +
Sbjct: 31864 GYYRVTATNTAGSTSCQAHLQV 31885
Score = 108 bits (270), Expect = 3e-23
Identities = 94/340 (27%), Positives = 149/340 (43%), Gaps = 49/340 (14%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F ++LK T G PVT TC++ G +V W++DG + R++ D
Sbjct: 6173 LPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDG--VLLRDDENLQTSFVDNVA 6230
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I T G Y+ A+NP G S S +RLT+
Sbjct: 6231 TLKILQTDLSHSGQYSCSASNPLGTASSS-----------ARLTA--------------- 6264
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
+EP + FF D++A G +C V+G P +TW + + + P ++ +
Sbjct: 6265 REPKKSPFF--DIKPVSIDVIA--GESADFECHVTGAQPMRITWSKDNKEIRPGGNYTIT 6320
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
H L I + + D+G Y C ATN G++ S +LS VK+ P ++KL+
Sbjct: 6321 CVGNTPH-LRILKVGKGDSGQYTCQATNDVGKDMCSAQLS-----VKEPPKFVKKLEASK 6374
Query: 1183 V-PEGHPVRLECRVIGMPP-PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
V +G ++LEC++ G P V +++ D+E + +S A L I A D
Sbjct: 6375 VAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSF---INSVALLTINEASAED 6431
Query: 1241 AGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
+G Y A N G SC+ L + A PP + +PS
Sbjct: 6432 SGDYICEAHNGVGDASCSTALTVKA------PPVFTQKPS 6465
Score = 107 bits (267), Expect = 8e-23
Identities = 104/390 (26%), Positives = 158/390 (40%), Gaps = 73/390 (18%)
Query: 888 GKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEI--PTGK---- 941
GK++T + +YKIS F N++ L+ V SD + E+ P GK
Sbjct: 7623 GKELT------SDNKYKISFF-----NKVS-GLKIINVAPSDSGVYSFEVQNPVGKDSCT 7670
Query: 942 --------CIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCK 993
+ P F ++LK GS V CK+ G P V WF +G +IS ++
Sbjct: 7671 ASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKY-- 7728
Query: 994 MRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHR 1053
D TC+L + D G+YT +A N G CS L V
Sbjct: 7729 QTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTV----------------- 7771
Query: 1054 GRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV 1113
+EP P F+Q P M G V G PP ++W +
Sbjct: 7772 ---------REP-------PSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSEL 7815
Query: 1114 LPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV 1173
+P + + ++ L D T + +G Y CI +N+ G+ S + L + KAP
Sbjct: 7816 VPGDRCNVSLEDSVAELELFDVDTSQ-SGEYTCIVSNEAGKASCTTHLYI------KAPA 7868
Query: 1174 -ILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACL 1231
+++L + + +G P+ LE G PP WKK+ + P R I+ T A L
Sbjct: 7869 KFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNIT---TTEKSAIL 7925
Query: 1232 LIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
I + DAG Y +N +G SC+A++
Sbjct: 7926 EIPSSTVEDAGQYNCYIENASGKDSCSAQI 7955
Score = 105 bits (262), Expect = 3e-22
Identities = 78/264 (29%), Positives = 111/264 (42%), Gaps = 35/264 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L++ V EG V L+C + G P P V WY E ++E+S D I + L
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 1001
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I EAF ED+GR++C A N GT STS + ++ + E
Sbjct: 1002 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE-------------------- 1041
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKP-IIAAPVFTKMLQNLSA 446
T+AV + + V V + G P I PV K++
Sbjct: 1042 --TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV----- 1094
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG VVF C+V G P P V W + G + +++ K C LVI+ F
Sbjct: 1095 -EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGE------CKLVISMTF 1147
Query: 507 AEDSGCFTCTASNKYGTVSSIAQL 530
A+D+G +T NK+G S+ A L
Sbjct: 1148 ADDAGEYTIVVRNKHGETSASASL 1171
Score = 102 bits (255), Expect = 2e-21
Identities = 88/323 (27%), Positives = 139/323 (43%), Gaps = 40/323 (12%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F ++L+ + T G PV F C I G V W+KDGK + ++ D T
Sbjct: 8055 LPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPL--KDSPNVQTSFLDNTA 8112
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L+I T G Y+ A NP G S S L++
Sbjct: 8113 TLNIFKTDRSLAGQYSCTATNPIGSASSSARLIL-------------------------- 8146
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
E FF AP D V G +C V+G P +++W + + + +++
Sbjct: 8147 TEGKNPPFF--DIRLAPVDAVV--GESADFECHVTGTQPIKVSWAKDSREIRSGGKYQIS 8202
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL-QNC 1181
E H L + + + D+G Y C A N+ G++S + +L++ KE P ++L +
Sbjct: 8203 YLENSAH-LTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNI--KERLIPPSFTKRLSETV 8259
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDN-ETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
EG+ +LE RV G P W K+N E P + I+ +T L ++ A +D
Sbjct: 8260 EETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNT---LVLQVRKAGMND 8316
Query: 1241 AGWYTLSAKNEAGIVSCTARLDI 1263
AG YT N+AG CT+ + I
Sbjct: 8317 AGLYTCKVSNDAGSALCTSSIVI 8339
Score = 102 bits (254), Expect = 2e-21
Identities = 90/325 (27%), Positives = 127/325 (39%), Gaps = 46/325 (14%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
VT+G P T K G WFKDG++++ +++ D L I ST D G
Sbjct: 4590 VTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKY--KISVTDTVSILKIISTEKKDSG 4647
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT N GR SC + V L I P F
Sbjct: 4648 EYTFEVQNDVGRSSCKARINVLDLIIP------------------------------PSF 4677
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
+ M + +G L+C V+G P + W + Q + +K + L I
Sbjct: 4678 TKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAF-LEISQ 4736
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
L D+GTY C ATNK G N S L+ VK+ P +EK Q+ V V+L+ V
Sbjct: 4737 LEGTDSGTYTCSATNKAGHNQCSGHLT-----VKEPPYFVEKPQSQDVNPNTRVQLKALV 4791
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G P W KDN+ + R DT+ L + AK +D+G Y N+ G
Sbjct: 4792 GGTAPMTIKWFKDNKELHSGAARSVWKDDTS--TSLELFAAKATDSGTYICQLSNDVGTA 4849
Query: 1256 SCTARLDIYAQWHHQIPPPMSVRPS 1280
+ A L + + PP +PS
Sbjct: 4850 TSKATLFV------KEPPQFIKKPS 4868
Score = 102 bits (253), Expect = 3e-21
Identities = 83/312 (26%), Positives = 126/312 (40%), Gaps = 42/312 (13%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+VT G T C + G P WFKDGK+++ N++ + L I + D
Sbjct: 7596 KVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKY--KISFFNKVSGLKIINVAPSDS 7653
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G Y+ NP G+ SC+ L V +R P
Sbjct: 7654 GVYSFEVQNPVGKDSCTASLQVS------------------------------DRTVPPS 7683
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
F + + G ++CKV G PP ++W G + ++ + + +L ++
Sbjct: 7684 FTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTC-ALTVN 7742
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECR 1194
L + D+G Y CIATN G + S L+ V++ P ++K V G V
Sbjct: 7743 MLEESDSGDYTCIATNMAGSDECSAPLT-----VREPPSFVQKPDPMDVLTGTNVTFTSI 7797
Query: 1195 VIGMPP-PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
V G PP V ++K +E +P R +S+ A L + S +G YT NEAG
Sbjct: 7798 VKGTPPFSVSWFKGSSELVPGDRCNVSLEDSV---AELELFDVDTSQSGEYTCIVSNEAG 7854
Query: 1254 IVSCTARLDIYA 1265
SCT L I A
Sbjct: 7855 KASCTTHLYIKA 7866
Score = 100 bits (250), Expect = 7e-21
Identities = 83/305 (27%), Positives = 126/305 (41%), Gaps = 47/305 (15%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G TF C+I G P +V W+ DG +I+ +H DG + I ++ G Y
Sbjct: 4876 GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFI--DGLATFQISGARVENSGTYV 4933
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
A N G SCS L V KEP P F++
Sbjct: 4934 CEARNDAGTASCSIELKV--------------------------KEP-------PTFIRE 4960
Query: 1079 --PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPL 1136
P ++V + L+C+V+G PP E+TWL N + + + + R V +L I
Sbjct: 4961 LKPVEVVKYSD--VELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDR-VSVFNLHITKC 5017
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
D G Y+CI +N+ G S S ++ +K+ P ++K++N + V
Sbjct: 5018 DPSDTGEYQCIVSNEGGSCSCSTRVA-----LKEPPSFIKKIENTTTVLKSSATFQSTVA 5072
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVS 1256
G PP W KD++ + D+ A L I+ +G YT AKNE+G+
Sbjct: 5073 GSPPISITWLKDDQILDEDDNVYISFVDSV--ATLQIRSVDNGHSGRYTCQAKNESGVER 5130
Query: 1257 CTARL 1261
C A L
Sbjct: 5131 CYAFL 5135
Score = 100 bits (249), Expect = 9e-21
Identities = 97/368 (26%), Positives = 142/368 (38%), Gaps = 77/368 (20%)
Query: 173 IRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQE 232
+R R+ K +E Q V++ + D+ + + I R V +E++
Sbjct: 3147 VRIRSIKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYV---VERRI 3202
Query: 233 AKRREAEQAASEAAGGDTTPGSSPSS--LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+ +E S+A G + SS LY P +PP+ Q+L+ V G +
Sbjct: 3203 HRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAP--EPPQVLQELQPVTVQSGKPARFCA 3260
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
++ G P P++ WY E + L + G ++L + EAF ED Y+C A N YG
Sbjct: 3261 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVA 3320
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRV 410
+TSA + +E EV SP V PPA+
Sbjct: 3321 TTSASLSVE---------------------VPEVVSPDQEMPVYPPAI------------ 3347
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYR 470
LQ+ SEGQ F+CRV G KV WY
Sbjct: 3348 ---------------------------ITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYS 3379
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+ I+ S FR M + E+ L IAE + ED G +T ASN G VSS A L
Sbjct: 3380 KDKKIKPSRFFR--------MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3431
Query: 531 HVRGNEDL 538
+ E +
Sbjct: 3432 SLEAPESI 3439
Score = 99.8 bits (247), Expect = 2e-20
Identities = 90/334 (26%), Positives = 132/334 (39%), Gaps = 45/334 (13%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F KRL F V GSP+ G P V W KD IS+ +E C + T L I
Sbjct: 6929 FVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQ-SERCSITMTEKSTI-LEI 6986
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
+T +D Y+ + N G+ C + V EP
Sbjct: 6987 LESTIEDYAQYSCLIENEAGQDICEALVSVL--------------------------EP- 7019
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P+F++ + A G L CKV G P ++W + ++KM +
Sbjct: 7020 ------PYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNN 7073
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
V SL+I+ + D G Y C A N G + S L + A+ K P KL++ G
Sbjct: 7074 -VASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKAR--KLPPFFARKLKDVHETLG 7130
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD-TTGYACLLIQPAKKSDAGWYT 1245
PV ECR+ G P W KD + ++ ++ A L I +S G Y
Sbjct: 7131 FPVAFECRINGSEPLQVSWYKDGVLL---KDDANLQTSFVHNVATLQILQTDQSHIGQYN 7187
Query: 1246 LSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
SA N G S +A+L + H++PP ++P
Sbjct: 7188 CSASNPLGTASSSAKLILS---EHEVPPFFDLKP 7218
Score = 99.0 bits (245), Expect = 3e-20
Identities = 89/318 (27%), Positives = 128/318 (40%), Gaps = 48/318 (15%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
+P FD + V G F C + G ++ W KD K+I + + G+ T
Sbjct: 6270 SPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYT-ITCVGN-TPH 6327
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I D G YT A N G+ CS L V K
Sbjct: 6328 LRILKVGKGDSGQYTCQATNDVGKDMCSAQLSV--------------------------K 6361
Query: 1064 EPLQERFFRPHFLQA-PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
EP P F++ VA +G +L+CK+SG P +++W N + + M
Sbjct: 6362 EP-------PKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMS 6414
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
+ V L I+ + D+G Y C A N G S S L+V K PV +K G
Sbjct: 6415 FINS-VALLTINEASAEDSGDYICEAHNGVGDASCSTALTV-----KAPPVFTQKPSPVG 6468
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTR--ERISMHQDTTGYACLLIQPAKKSD 1240
+G V L+C + G PP W KD + + ++ + S H DT+ L I + SD
Sbjct: 6469 ALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTS----LHILNLEASD 6524
Query: 1241 AGWYTLSAKNEAGIVSCT 1258
G Y A NE G +C+
Sbjct: 6525 VGEYHCKATNEVGSDTCS 6542
Score = 98.2 bits (243), Expect = 5e-20
Identities = 98/346 (28%), Positives = 139/346 (40%), Gaps = 46/346 (13%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
+ L+ V G P F I G P PK+ W+K+ +Q+ CK +G L IE+
Sbjct: 3243 QELQPVTVQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEA 3301
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
+D YT A N G + S L V+ + S P QE
Sbjct: 3302 FP-EDAAVYTCEAKNDYGVATTSASLSVEVPEVVS---------------------PDQE 3339
Query: 1069 RFFRPHFLQAP-GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P + P D V EG+ R C+VSG +++W + + P +M E
Sbjct: 3340 MPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFED- 3397
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE--------------VKKAPV 1173
+ L I D GTY +A+N GQ S + LS+ A E +K APV
Sbjct: 3398 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPV 3457
Query: 1174 ILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLI 1233
I K++ V GH + C + P F W K I ++ S+ + + + L I
Sbjct: 3458 IKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREI-YESDKCSI-RSSKYISSLEI 3515
Query: 1234 QPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
+ D G YT A NE G VSCTA L + + PP RP
Sbjct: 3516 LRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAY----PPTFLSRP 3557
Score = 97.4 bits (241), Expect = 8e-20
Identities = 87/323 (26%), Positives = 135/323 (41%), Gaps = 49/323 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVT-FTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG-DGTC 1002
P F K+L+ R+ + T + CKI G P KV W+KD +I E K R D
Sbjct: 7305 PRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQ---ESSKFRMSFVDSVA 7361
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L + + + +D G+YT A N G S S L V
Sbjct: 7362 VLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKV-------------------------- 7395
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
KEP P F + P + +G L+C++ G PP ++W + + + +K++
Sbjct: 7396 KEP-------PIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIM 7448
Query: 1123 VRE--TGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQN 1180
T +H L +D D G Y+C ATN G ++ V + +K P ++KL +
Sbjct: 7449 SENFLTSIHILNVD---AADIGEYQCKATNDVGSDT-----CVGSIALKAPPRFVKKLSD 7500
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
G V+L+ + G P W KD I + I + + A L + ++
Sbjct: 7501 ISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISY-SENIATLQFSRVEPAN 7559
Query: 1241 AGWYTLSAKNEAGIVSCTARLDI 1263
AG YT KN+AG+ C A L +
Sbjct: 7560 AGKYTCQIKNDAGMQECFATLSV 7582
Score = 96.7 bits (239), Expect = 1e-19
Identities = 83/333 (24%), Positives = 136/333 (40%), Gaps = 48/333 (14%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F ++ V G+ VTFT + G P V WFK ++ + C + E D L
Sbjct: 7775 PSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVP-GDRCNVSLE-DSVAEL 7832
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ + G YT + +N G+ SC+ HL + K
Sbjct: 7833 ELFDVDTSQSGEYTCIVSNEAGKASCTTHLYI--------------------------KA 7866
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P + F++ D +G+ L+ +G PP +TW NG V P +
Sbjct: 7867 PAK-------FVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTT 7919
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
E L I T DAG Y C N +G++S S ++ ++ + P +++L+ V
Sbjct: 7920 EKSA-ILEIPSSTVEDAGQYNCYIENASGKDSCSAQILIL-----EPPYFVKQLEPVKVS 7973
Query: 1185 EGHPVRLECRVIGMPP-PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G L+C++ G P V ++K D + P T ++ + A L+ +D+G
Sbjct: 7974 VGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNV---ATLVFNQVDINDSGE 8030
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
Y A+N G VS + L + Q ++PP S
Sbjct: 8031 YICKAENSVGEVSASTFLTVQEQ---KLPPSFS 8060
Score = 96.3 bits (238), Expect = 2e-19
Identities = 87/323 (26%), Positives = 124/323 (38%), Gaps = 46/323 (14%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P F K+LK +GS + C + G + WFKD ++IS +E K D T
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISA-SEKYKFSFH-DNTA 4730
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L I D G YT A N G CSGHL V
Sbjct: 4731 FLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTV-------------------------- 4764
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
KEP P+F++ P + +L V G P + W + + + A+ +
Sbjct: 4765 KEP-------PYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVW 4817
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
+T SL + D+GTY C +N G + L V K+ P ++K
Sbjct: 4818 KDDTST-SLELFAAKATDSGTYICQLSNDVGTATSKATLFV-----KEPPQFIKKPSPVL 4871
Query: 1183 V-PEGHPVRLECRVIGMPPPVFYWKKD-NETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
V G EC++ G P W D NE + IS G A I A+ +
Sbjct: 4872 VLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISF---IDGLATFQISGARVEN 4928
Query: 1241 AGWYTLSAKNEAGIVSCTARLDI 1263
+G Y A+N+AG SC+ L +
Sbjct: 4929 SGTYVCEARNDAGTASCSIELKV 4951
Score = 96.3 bits (238), Expect = 2e-19
Identities = 86/321 (26%), Positives = 125/321 (38%), Gaps = 40/321 (12%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P FD RL G F C + G KV W KD ++I ++ E + L
Sbjct: 8153 PFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLE--NSAHL 8210
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ D G YT A N G+ SC+ L +
Sbjct: 8211 TVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNI---------------------------- 8242
Query: 1065 PLQERFFRPHFLQAPGDMVAH-EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
+ER P F + + V EG +L+ +V+G P + W N + P ++ ++
Sbjct: 8243 --KERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITF 8300
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGV 1183
+ + L + DAG Y C +N G S S+V KE KK PV + L V
Sbjct: 8301 KNNTL-VLQVRKAGMNDAGLYTCKVSNDAG--SALCTSSIVIKEPKKPPVFDQHLTPVTV 8357
Query: 1184 PEGHPVRLECRVIGMPPPVFYW-KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
EG V+L C V G P W K E P R S +G A L ++ K+D+G
Sbjct: 8358 SEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSF---ASGTAVLELRDVAKADSG 8414
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
Y A N AG + +++ I
Sbjct: 8415 DYVCKASNVAGSDTTKSKVTI 8435
Score = 95.9 bits (237), Expect = 2e-19
Identities = 88/329 (26%), Positives = 132/329 (40%), Gaps = 46/329 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F + LK V + S V C++ G P +V W K+ ++I ++ R +L
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVS--VFNL 5012
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
HI D G Y + +N G SCS + + KE
Sbjct: 5013 HITKCDPSDTGEYQCIVSNEGGSCSCSTRVAL--------------------------KE 5046
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P P F++ + V+G PP +TWL + Q +L + + +
Sbjct: 5047 P-------PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQ-ILDEDDNVYISF 5098
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V +L I + +G Y C A N++G +E V++ I+EK ++ V
Sbjct: 5099 VDSVATLQIRSVDNGHSGRYTCQAKNESG-----VERCYAFLLVQEPAQIVEKAKSVDVT 5153
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
E P+ LEC V G P W KD + I +R SM + A IQ K D+G Y
Sbjct: 5154 EKDPMTLECVVAGTPELKVKWLKDGKQIVPSR-YFSMSFE-NNVASFRIQSVMKQDSGQY 5211
Query: 1245 TLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
T +N+ G SC A L + Q IPP
Sbjct: 5212 TFKVENDFGSSSCDAYLRVLDQ---NIPP 5237
Score = 95.5 bits (236), Expect = 3e-19
Identities = 92/340 (27%), Positives = 142/340 (41%), Gaps = 54/340 (15%)
Query: 945 PIFDKRLKHFRVT-EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG-DGTC 1002
P F K+L+ +V +G + CKI G P KV WF++ ++ +E K +
Sbjct: 6364 PKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSEL---HESWKYNMSFINSVA 6420
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L I +++D G+Y A N G SCS L V++ P+
Sbjct: 6421 LLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPV--------------------- 6459
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F Q P + A +G L C++SG PP E+ W+ + + V K+
Sbjct: 6460 ------------FTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKIT 6507
Query: 1123 VR--ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQN 1180
+ +T +H L L D G Y C ATN+ G ++ S + + K+ P ++KL +
Sbjct: 6508 SKHFDTSLHIL---NLEASDVGEYHCKATNEVGSDTCSCSV-----KFKEPPRFVKKLSD 6559
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE--RISMHQDTTGYACLLIQPAKK 1238
G V L V G P W KD + E RIS A L + +
Sbjct: 6560 TSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISF---IDNIATLQLGSPEA 6616
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYAQWH-HQIPPPMSV 1277
S++G Y KN+AG+ C+A L + + P PM+V
Sbjct: 6617 SNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTV 6656
Score = 95.1 bits (235), Expect = 4e-19
Identities = 112/442 (25%), Positives = 170/442 (38%), Gaps = 71/442 (16%)
Query: 818 SPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIR 877
S T ++ P +F+ V PS +P +A + S Q KN K N +
Sbjct: 3728 SATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMY 3787
Query: 878 ETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEI 937
+ I D+ +DV+ S+ +N++ D EI E
Sbjct: 3788 FVNSEAILDI------TDVKVEDS----GSYSCEAVNDVGS-------DSCSTEIVIKEP 3830
Query: 938 PTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE 997
P+ F K L+ + G+ C++ G ++ WFKD KQI ++ ++ +
Sbjct: 3831 PS-------FIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKY-RLFSQ 3882
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSG-HLMVQSLPIRSRLTSAGQSHRGRS 1056
C L I S S D G Y + AN G+ C HL+
Sbjct: 3883 KSLVC-LEIFSFNSADVGEYECVVANEVGKCGCMATHLL--------------------- 3920
Query: 1057 RVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD 1116
KEP P F++ D++A G+ L V G P +TW + GQ V+ +
Sbjct: 3921 ------KEP-------PTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTW-MKGQEVIRE 3966
Query: 1117 ASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILE 1176
+ GV L+I + G Y C+A N+ G + SV VK+ I+E
Sbjct: 3967 DGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS-----QTSVGELIVKEPAKIIE 4021
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQP 1235
+ + V G P LE V G P W KD + +++ RIS + A L
Sbjct: 4022 RAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNV---AQLKFYS 4078
Query: 1236 AKKSDAGWYTLSAKNEAGIVSC 1257
A+ D+G YT NE G SC
Sbjct: 4079 AELHDSGQYTFEISNEVGSSSC 4100
Score = 94.7 bits (234), Expect = 5e-19
Identities = 85/323 (26%), Positives = 131/323 (40%), Gaps = 43/323 (13%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F ++LK T G PV F C+I G +V W+KDG + +++
Sbjct: 7114 LPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDG--VLLKDDANLQTSFVHNVA 7171
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I T G Y A+NP G S S L+
Sbjct: 7172 TLQILQTDQSHIGQYNCSASNPLGTASSSAKLI--------------------------- 7204
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
L E P F P + G C V+G P ++TW + + + P ++KM
Sbjct: 7205 ---LSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMT 7261
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
+ E +L + + + DAG Y C A+N G++S S +L V++ P ++KL+
Sbjct: 7262 LVE-NTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLG-----VQEPPRFIKKLEPSR 7315
Query: 1183 -VPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSD 1240
V + R EC++ G P W KD I ++ R+S A L + D
Sbjct: 7316 IVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSF---VDSVAVLEMHNLSVED 7372
Query: 1241 AGWYTLSAKNEAGIVSCTARLDI 1263
+G YT A N AG S + L +
Sbjct: 7373 SGDYTCEAHNAAGSASSSTSLKV 7395
Score = 94.4 bits (233), Expect = 7e-19
Identities = 85/320 (26%), Positives = 128/320 (40%), Gaps = 45/320 (14%)
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
+ + P F +RLK+ G+ CK+ G V WF + +I ++ D
Sbjct: 5796 RAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKY--QTTFSDN 5853
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
C+L + S S D GNYT +AAN G C L VQ
Sbjct: 5854 VCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQ----------------------- 5890
Query: 1061 RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHK 1120
EP P F++ P + G+ + G PP ++ W + ++
Sbjct: 5891 ---EP-------PSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCN 5940
Query: 1121 MLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQN 1180
+ +T V L + + +G Y C+ +N GQ S + L V K+ L++L +
Sbjct: 5941 IYFEDT-VAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFV-----KEPAAFLKRLSD 5994
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKS 1239
V G + LE G P WKKD I T E+ ++ TT C+L I + K
Sbjct: 5995 HSVEPGKSIILESTYTGTLPISVTWKKDGFNI-TTSEKCNI--VTTEKTCILEILNSTKR 6051
Query: 1240 DAGWYTLSAKNEAGIVSCTA 1259
DAG Y+ +NEAG C A
Sbjct: 6052 DAGQYSCEIENEAGRDVCGA 6071
Score = 94.4 bits (233), Expect = 7e-19
Identities = 92/337 (27%), Positives = 130/337 (38%), Gaps = 42/337 (12%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F K+L+ +V+ G + C++ G P V W+K ++ + R T L
Sbjct: 7961 PYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVAT--L 8018
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+D G Y A N G +S S L VQ
Sbjct: 8019 VFNQVDINDSGEYICKAENSVGEVSASTFLTVQ--------------------------- 8051
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
E+ P F + D+ G DC +SG P ++W +G+P L D+ +
Sbjct: 8052 ---EQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKP-LKDSPNVQTSF 8107
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
+L I + AG Y C ATN G S S L + E K P +L
Sbjct: 8108 LDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARL--ILTEGKNPPFFDIRLAPVDAV 8165
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKSDAGW 1243
G EC V G P W KD+ I + +IS +++ A L + K D+G
Sbjct: 8166 VGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENS---AHLTVLKVDKGDSGQ 8222
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
YT A NE G SCTA+L+I IPP + R S
Sbjct: 8223 YTCYAVNEVGKDSCTAQLNIK---ERLIPPSFTKRLS 8256
Score = 94.0 bits (232), Expect = 9e-19
Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 37/255 (14%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + L+ V EGS TF I G PVP+V WF+DG+ IS DG
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + T + G Y++ A N G+ + + L+V++ +
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-----------------------ET 101
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
P P+F+Q M +G RL +V+G+P P + + +G + + +
Sbjct: 102 AP-------PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQ-IS 153
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE---VKKAPVILEKLQN 1180
+E ++SLLI D+GTY ATN G+ + + EL V +E KK I+ Q
Sbjct: 154 QEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ- 212
Query: 1181 CGVPEGHPVRLECRV 1195
+ E R+E ++
Sbjct: 213 --ISESRQTRIEKKI 225
Score = 94.0 bits (232), Expect = 9e-19
Identities = 90/319 (28%), Positives = 124/319 (38%), Gaps = 46/319 (14%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
IAP F K L++ CKI G +V WFKDGK+I+ + + EG T
Sbjct: 4111 IAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEG--TA 4168
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL I +D GN+T A N G SG L+VQ
Sbjct: 4169 SLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQ------------------------- 4203
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
EP P F+ PG G L G P + W G L +
Sbjct: 4204 -EP-------PSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWF-KGNKELVSGGSCYI 4254
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
+E SL + + D+GTY C +N G S L VK+ +EKL+
Sbjct: 4255 TKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLF-----VKEPATFVEKLEPSQ 4309
Query: 1183 -VPEGHPVRLECRVIGMPPPVFYW-KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
+ +G +L C+V G PP W D E ++ R+S + T A L + D
Sbjct: 4310 LLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVEST---AVLRLTDVGIED 4366
Query: 1241 AGWYTLSAKNEAGIVSCTA 1259
+G Y A+NEAG C++
Sbjct: 4367 SGEYMCEAQNEAGSDHCSS 4385
Score = 93.2 bits (230), Expect = 1e-18
Identities = 83/323 (25%), Positives = 137/323 (42%), Gaps = 45/323 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F + L+H G P T CK+ G P ++ W+K+ ++ + KM+ + + SL
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAY-KMQFKNN-VASL 7077
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I D G Y+ A N G ++ S L++++
Sbjct: 7078 VINKVDHSDVGEYSCKADNSVGAVASSAVLVIKA-------------------------- 7111
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
R P F + D+ G +C+++G P +++W +G + DA+ ++
Sbjct: 7112 ----RKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDAN----LQ 7163
Query: 1125 ETGVHSLLIDPLTQRDA---GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
+ VH++ + Q D G Y C A+N G S S +L + EV P K +
Sbjct: 7164 TSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVP--PFFDLKPVSV 7221
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSD 1240
+ G +C V G P W KDN I P ++++ ++T A L + K D
Sbjct: 7222 DLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENT---ATLTVLKVGKGD 7278
Query: 1241 AGWYTLSAKNEAGIVSCTARLDI 1263
AG YT A N AG SC+A+L +
Sbjct: 7279 AGQYTCYASNIAGKDSCSAQLGV 7301
Score = 92.0 bits (227), Expect = 3e-18
Identities = 86/341 (25%), Positives = 132/341 (38%), Gaps = 54/341 (15%)
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
+ + P F ++LK G+ V C++ G V WF+DG +I C+ +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVS-GPKCQSSFS-EN 6794
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
C+L++ D G YT +AAN G CS L VQ
Sbjct: 6795 VCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQ----------------------- 6831
Query: 1061 RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHK 1120
EP P F Q P + G + G PP ++ W + ++P S
Sbjct: 6832 ---EP-------PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCN 6881
Query: 1121 MLVRE--TGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
+ + + T + + PL ++G Y C+ TN G S + L V K+ +++L
Sbjct: 6882 ISLEDFVTELELFEVQPL---ESGDYSCLVTNDAGSASCTTHLFV-----KEPATFVKRL 6933
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ V G P+ LE G PP W KD E + ER S+ T L I +
Sbjct: 6934 ADFSVETGSPIVLEATYTGTPPISVSWIKD-EYLISQSERCSITM-TEKSTILEILESTI 6991
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
D Y+ +NEAG C A + + + PP + P
Sbjct: 6992 EDYAQYSCLIENEAGQDICEALVSV-------LEPPYFIEP 7025
Score = 91.7 bits (226), Expect = 4e-18
Identities = 58/165 (35%), Positives = 88/165 (53%), Gaps = 12/165 (7%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F Q+L+S V +G++V+L V GIP P V++Y +G E+++S D I Q G+L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL 162
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG--------VSSSDSEGDPNKEEMNRIQ 379
IAEA+ ED+G YS A+N G +++AE+ ++G + S ++ RI+
Sbjct: 163 IAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIE 222
Query: 380 KPNE----VSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
K E S T VI A Q PR+ + +SPT
Sbjct: 223 KKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSPT 267
Score = 90.5 bits (223), Expect = 1e-17
Identities = 78/318 (24%), Positives = 126/318 (39%), Gaps = 44/318 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F ++ + V + V + G + WFKD K++ + + + D + SL
Sbjct: 4768 PYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKEL--HSGAARSVWKDDTSTSL 4825
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ + + D G Y +N G + L V KE
Sbjct: 4826 ELFAAKATDSGTYICQLSNDVGTATSKATLFV--------------------------KE 4859
Query: 1065 PLQERFFRPHFLQAPGD-MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
P P F++ P +V G+ +C+++G P ++W L+G + H +
Sbjct: 4860 P-------PQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISF 4912
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGV 1183
+ G+ + I ++GTY C A N G S S+EL +VK+ P + +L+ V
Sbjct: 4913 ID-GLATFQISGARVENSGTYVCEARNDAGTASCSIEL-----KVKEPPTFIRELKPVEV 4966
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
+ V LEC V G PP W K+N I +++ D L I SD G
Sbjct: 4967 VKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTL--TDRVSVFNLHITKCDPSDTGE 5024
Query: 1244 YTLSAKNEAGIVSCTARL 1261
Y NE G SC+ R+
Sbjct: 5025 YQCIVSNEGGSCSCSTRV 5042
Score = 90.5 bits (223), Expect = 1e-17
Identities = 91/376 (24%), Positives = 143/376 (38%), Gaps = 70/376 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V EG F+C G PVP V W + G+ +S H + T I S + D+G
Sbjct: 32572 VYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKST--FEISSVQASDEG 32629
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG---QSHRGRSRVQERDKEPLQERFFR 1072
NY+++ N +G+ L +Q + + ++ +S R + E K P + +
Sbjct: 32630 NYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPE 32689
Query: 1073 PHFLQA---------PGDMVAH-----------------EGRLCRLDCKV--SGLPPPEL 1104
P +A P + V H + +L C V S L E+
Sbjct: 32690 PSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEV 32749
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL----- 1159
TW +G+ + + + G + L I+ LT+ D G Y C + + G + +L
Sbjct: 32750 TWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQ 32809
Query: 1160 -----------------------ELSVVAKEVKKA-------PVILEKLQNCGVPEGHPV 1189
E +V K KA PVI+ LQ+ V
Sbjct: 32810 AFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVA 32869
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+ + G P P W KD + I + + +D G+ L I SD+G YT + K
Sbjct: 32870 KFAVKATGEPRPTAIWTKDGKAI-TQGGKYKLSEDKGGF-FLEIHKTDTSDSGLYTCTVK 32927
Query: 1250 NEAGIVSCTARLDIYA 1265
N AG VS + +L I A
Sbjct: 32928 NSAGSVSSSCKLTIKA 32943
Score = 90.1 bits (222), Expect = 1e-17
Identities = 75/313 (23%), Positives = 130/313 (41%), Gaps = 47/313 (15%)
Query: 945 PIFDKRLKHFRVTE-GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
P F K+L+ ++ + G CKI G P +V WF++ ++ +++ D
Sbjct: 5423 PKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKY--RMTFIDSVAV 5480
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
+ + + +++D G++ A NP G SCS ++V K
Sbjct: 5481 IQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIV--------------------------K 5514
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
EP P F P + + L+C++SG PP E+ W + + + +K+
Sbjct: 5515 EP-------PVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIAS 5567
Query: 1124 RE--TGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
+ T +H L +D D G Y C A N+ G ++ V ++K+ P + KL +
Sbjct: 5568 KNFHTSIHILNVDT---SDIGEYHCKAQNEVGSDT-----CVCTVKLKEPPRFVSKLNSL 5619
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V G P L+ + G P W K+ E + E I + A L A+ ++A
Sbjct: 5620 TVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRI-TFVENVATLQFAKAEPANA 5678
Query: 1242 GWYTLSAKNEAGI 1254
G Y KN+ G+
Sbjct: 5679 GKYICQIKNDGGM 5691
Score = 89.7 bits (221), Expect = 2e-17
Identities = 74/320 (23%), Positives = 128/320 (40%), Gaps = 44/320 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
PIF K+ +G+ V C++ G P V W+KD +++ ++ K+ E T S+
Sbjct: 7399 PIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKY-KIMSENFLT-SI 7456
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
HI + + D G Y A N G +C G + +++
Sbjct: 7457 HILNVDAADIGEYQCKATNDVGSDTCVGSIALKA-------------------------- 7490
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P F++ D+ G+ +L + G P + W + ++ ++ + +
Sbjct: 7491 -------PPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISY 7543
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
+ +L + +AG Y C N G LSV+ + I+EK ++ V
Sbjct: 7544 SENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVL-----EPATIVEKPESIKVT 7598
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPC-TRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G LEC V G P W KD + + + +IS +G + + P SD+G
Sbjct: 7599 TGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAP---SDSGV 7655
Query: 1244 YTLSAKNEAGIVSCTARLDI 1263
Y+ +N G SCTA L +
Sbjct: 7656 YSFEVQNPVGKDSCTASLQV 7675
Score = 89.4 bits (220), Expect = 2e-17
Identities = 70/308 (22%), Positives = 131/308 (42%), Gaps = 43/308 (13%)
Query: 259 LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV 318
L + L P F + RS+ + EG V C + G P P++ W+ + S ++ I
Sbjct: 33124 LTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSIS 33183
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI---------------EGVSS 363
++ N++SL I A D+G+Y+ A N G S +A + + G +S
Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTS 33243
Query: 364 SDSEGDPNKEEMNRIQKPNEVSSPPTTSA----VIPPAVPQAQHLVAQPR---------- 409
+M+ ++ SS ++SA + A AQ + +
Sbjct: 33244 LQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSF 33303
Query: 410 --VATIQQCQSPTNYL--QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
++ + Q +S T+ + G+ G P P + ++S EG+++ C G P+P+
Sbjct: 33304 MGISNMTQLESSTSKMLKAGIRGIP----PKIEALPSDISIDEGKVLTVACAFTGEPTPE 33359
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
V W G I R + +++ TL+I +V +D G +T + N++G+ S
Sbjct: 33360 VTWSCGGRKIHSQEQGRF------HIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 33413
Query: 526 SIAQLHVR 533
+ +H+R
Sbjct: 33414 ATVNIHIR 33421
Score = 88.6 bits (218), Expect = 4e-17
Identities = 101/387 (26%), Positives = 143/387 (36%), Gaps = 79/387 (20%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F K +K +V E F C+ V P V W KD +++ + + K+++E L I
Sbjct: 3060 FRKHIKDIKVLEKKRAMFECE-VSEPDITVQWMKDDQEL-QITDRIKIQKE-KYVHRLLI 3116
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR--------- 1057
ST D G YT++A G +S + L V+ +R R + R
Sbjct: 3117 PSTRMSDAGKYTVVAG---GNVS-TAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNE 3172
Query: 1058 -----------------VQERDKEPLQERFFR---------------------------- 1072
VQER K ++ R R
Sbjct: 3173 DDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLY 3232
Query: 1073 ------PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P LQ + G+ R +SG P P+++W Q + K L +
Sbjct: 3233 VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL-HDG 3291
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA--------PVILEKL 1178
++LL+ DA Y C A N G + S LSV EV P I+ L
Sbjct: 3292 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3351
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ EG P R +CRV G V ++ KD + P R++ +DT L I A
Sbjct: 3352 QDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ---LEIAEAYP 3408
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYA 1265
D G YT A N G VS TA L + A
Sbjct: 3409 EDEGTYTFVASNAVGQVSSTANLSLEA 3435
Score = 88.2 bits (217), Expect = 5e-17
Identities = 85/310 (27%), Positives = 124/310 (40%), Gaps = 46/310 (14%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V GS V G + WFK K++ C + +E + SL + + D G
Sbjct: 4217 VLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGS-CYITKEALES-SLELYLVKTSDSG 4274
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQ-ERFFRPH 1074
YT +N G + CS +L V KEP P
Sbjct: 4275 TYTCKVSNVAGGVECSANLFV--------------------------KEPATFVEKLEPS 4308
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM-LVRETGVHSLLI 1133
L GD +L CKV+G PP ++TW N + + + H+M V T V L +
Sbjct: 4309 QLLKKGDAT-------QLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAV--LRL 4359
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ D+G Y C A N+ G + S S+V VK++P ++ + V + + V L
Sbjct: 4360 TDVGIEDSGEYMCEAQNEAGSDHCS---SIVI--VKESPYFTKEFKPIEVLKEYDVMLLA 4414
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
V G PP W KDN + R+ + QD L I +DAG Y NE G
Sbjct: 4415 EVAGTPPFEITWFKDNTILRSGRKYKTFIQD--HLVSLQILKFVAADAGEYQCRVTNEVG 4472
Query: 1254 IVSCTARLDI 1263
C+AR+ +
Sbjct: 4473 SSICSARVTL 4482
Score = 87.8 bits (216), Expect = 6e-17
Identities = 85/318 (26%), Positives = 127/318 (39%), Gaps = 48/318 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F K L+ + V C++ V W KDG+++ ++ K+ E D +L
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDY-KICFE-DKIATL 3701
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I D G Y A+N G SCS + V+ P S V++ D
Sbjct: 3702 EIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPP---------------SFVKKVD-- 3744
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P +L PG+ RL CK+ G P ++TW N + + S VR
Sbjct: 3745 --------PSYLMLPGESA-------RLHCKLKGSPVIQVTWFKNNK----ELSESNTVR 3785
Query: 1125 ETGVHSLLIDPLTQ---RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
V+S I +T D+G+Y C A N G +S S E+ + K+ P ++ L+
Sbjct: 3786 MYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVI-----KEPPSFIKTLEPA 3840
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
+ G L+C V G P W KD + I +++ Q + CL I +D
Sbjct: 3841 DIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKS--LVCLEIFSFNSADV 3898
Query: 1242 GWYTLSAKNEAGIVSCTA 1259
G Y NE G C A
Sbjct: 3899 GEYECVVANEVGKCGCMA 3916
Score = 87.8 bits (216), Expect = 6e-17
Identities = 75/290 (25%), Positives = 125/290 (43%), Gaps = 32/290 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F +KL+ G V +C + G P QV WY +G L++ ++ N+ +L
Sbjct: 7115 PPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQ 7174
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYI-----------EGVSSSDSEGDPNKEEMN 376
I + + G+Y+C ASN GT S+SA++ + + VS + G+ + +
Sbjct: 7175 ILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCH 7234
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP-----TNYLQGLDGKPI 431
+ + I P LV T+ + T Y + GK
Sbjct: 7235 VTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDS 7294
Query: 432 IAA-------PVFTKMLQ-NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
+A P F K L+ + + + +EC++ G+P KV WY++ T I++S FR
Sbjct: 7295 CSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFR- 7353
Query: 484 LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
M+ + + L + + EDSG +TC A N G+ SS L V+
Sbjct: 7354 -------MSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK 7396
Score = 87.8 bits (216), Expect = 6e-17
Identities = 63/213 (29%), Positives = 86/213 (40%), Gaps = 25/213 (11%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GTCSLHIESTTSDDDGNY 1017
G V F I P P V W+K G++I + K E D G L I S T+DDD Y
Sbjct: 31704 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 31763
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
T++A N G SC L V P P + RP F +
Sbjct: 31764 TVVARNKYGEDSCKAKLTVTLHP------------------------PPTDSTLRPMFKR 31799
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
+ EG+ + +VSG+PPP L W +GQP+ + +++ ++L I
Sbjct: 31800 LLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTL 31859
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK 1170
D G Y+ ATN G S L V KK
Sbjct: 31860 PEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 31892
Score = 87.4 bits (215), Expect = 8e-17
Identities = 80/323 (24%), Positives = 122/323 (37%), Gaps = 60/323 (18%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
+R + +VT G P T + G P K W+KDG+ + ++ + + L S
Sbjct: 4021 ERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFK--NNVAQLKFYS 4078
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
D G YT +N G SC V +
Sbjct: 4079 AELHDSGQYTFEISNEVGSSSCETTFTVL------------------------------D 4108
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
R P F + ++ + CRLDCK++G P ++W +G+ + +++ E G
Sbjct: 4109 RDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE-GT 4167
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
SL I + DAG + C ATN G S L V++ P + K + V G
Sbjct: 4168 ASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALI-----VQEPPSFVTKPGSKDVLPGSA 4222
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA----------KK 1238
V L+ G P W K N+ + +G +C + + A K
Sbjct: 4223 VCLKSTFQGSTPLTIRWFKGNKEL------------VSGGSCYITKEALESSLELYLVKT 4270
Query: 1239 SDAGWYTLSAKNEAGIVSCTARL 1261
SD+G YT N AG V C+A L
Sbjct: 4271 SDSGTYTCKVSNVAGGVECSANL 4293
Score = 87.4 bits (215), Expect = 8e-17
Identities = 80/324 (24%), Positives = 125/324 (38%), Gaps = 44/324 (13%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P FD + + G TF C + G K+ W KD ++I + KM + T
Sbjct: 7210 VPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNY-KMTLV-ENTA 7267
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L + D G YT A+N G+ SCS L VQ P
Sbjct: 7268 TLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPP---------------------- 7305
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
RF + + + + R +CK+ G P ++ W + + + +M
Sbjct: 7306 ------RFIK----KLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMS 7355
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
++ V L + L+ D+G Y C A N G S S L +VK+ P+ +K
Sbjct: 7356 FVDS-VAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSL-----KVKEPPIFRKKPHPIE 7409
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDA 1241
+G V LEC + G PP W KD + ++ +I T L + A D
Sbjct: 7410 TLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAA---DI 7466
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYA 1265
G Y A N+ G +C + + A
Sbjct: 7467 GEYQCKATNDVGSDTCVGSIALKA 7490
Score = 86.7 bits (213), Expect = 1e-16
Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 9/202 (4%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR-ETGVHSL 1131
P F Q +V EG + +SG P PE++W +GQ + + + G L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I +T+ ++G Y ATN +GQ + + EL V A+ P +++LQ+ V +G VRL
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAP--PNFVQRLQSMTVRQGSQVRL 123
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ RV G+P PV + +D I + + +IS D LLI A D+G Y+++A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYS---LLIAEAYPEDSGTYSVNATN 180
Query: 1251 EAGIVSCTARLDIYAQWHHQIP 1272
G + TA ++ Q ++P
Sbjct: 181 SVGRATSTA--ELLVQGEEEVP 200
Score = 86.7 bits (213), Expect = 1e-16
Identities = 81/321 (25%), Positives = 126/321 (39%), Gaps = 46/321 (14%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P F K+L GS + CK+ G WFKDGK+IS ++ + E +
Sbjct: 5235 IPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHER--SV 5292
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL + + +D NYT +N G +CSG L V
Sbjct: 5293 SLEVNNLELEDTANYTCKVSNVAGDDACSGILTV-------------------------- 5326
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
KEP P FL PG A + G PP ++ W + ++ + K
Sbjct: 5327 KEP-------PSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELV--SGPKCF 5377
Query: 1123 VRETGVHSLL-IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
+ G S L + + G Y C TN G +S + L V + P ++KL+
Sbjct: 5378 IGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVT-----EPPKFVKKLEAS 5432
Query: 1182 G-VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
V G RLEC++ G P W ++ +P + + D+ A + + D
Sbjct: 5433 KIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSV--AVIQMNNLSTED 5490
Query: 1241 AGWYTLSAKNEAGIVSCTARL 1261
+G + A+N AG SC+ ++
Sbjct: 5491 SGDFICEAQNPAGSTSCSTKV 5511
Score = 86.7 bits (213), Expect = 1e-16
Identities = 81/329 (24%), Positives = 128/329 (38%), Gaps = 46/329 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F K + V G VTFT I G P KV WF+ +++ K + C + E D L
Sbjct: 5893 PSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVK-GDRCNIYFE-DTVAEL 5950
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ + G YT + +N G+ SC+ L V KE
Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAGQASCTTRLFV--------------------------KE 5984
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P FL+ D G+ L+ +G P +TW +G + ++
Sbjct: 5985 PAA-------FLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTT 6037
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
E +++ T+RDAG Y C N+ G++ +S + + P + +L+
Sbjct: 6038 EKTCILEILNS-TKRDAGQYSCEIENEAGRDVCGALVSTL-----EPPYFVTELEPLEAA 6091
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G V L+C+V G P W K + + T E + T A L+ +D+G Y
Sbjct: 6092 VGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYF--TNNVATLVFNKVNINDSGEY 6149
Query: 1245 TLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
T A+N G S ++ Q+PP
Sbjct: 6150 TCKAENSIGTASSKT---VFRIQERQLPP 6175
Score = 86.7 bits (213), Expect = 1e-16
Identities = 70/290 (24%), Positives = 114/290 (39%), Gaps = 34/290 (11%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP F QK +V GT V IV G PP V W+ EL ++ ++ L
Sbjct: 7773 EPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAEL 7832
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--------SDSEGDP-------- 370
+ + +G Y+C SN G S + +YI+ + S +G P
Sbjct: 7833 ELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFT 7892
Query: 371 NKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKP 430
++ K N ++ P+ I A + + +T++ Y++ GK
Sbjct: 7893 GTPPISVTWKKNGINVTPSQRCNITTTEKSA---ILEIPSSTVEDAGQYNCYIENASGKD 7949
Query: 431 -------IIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
I+ P F K L+ + S G +C++ G P V WY+ T + + ++
Sbjct: 7950 SCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYK- 8008
Query: 484 LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
M + TLV +V DSG + C A N G VS+ L V+
Sbjct: 8009 -------MHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051
Score = 86.3 bits (212), Expect = 2e-16
Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 21/273 (7%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--DIHIVQAGNLHSLTI 328
F ++++ + EG V C + G P P++ WY +GK +++ + +Q G SL I
Sbjct: 1293 FDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRA-SLRI 1351
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEG-DPNKEEMNRIQ--KPNEVS 385
ED G Y+ FASNI G S ++Y+E + + P E ++RI+ P VS
Sbjct: 1352 PVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1411
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI--IAAPVFTKMLQN 443
P + P + A+ A+ A + SP L+ D + + PVF +
Sbjct: 1412 RSPIRMS--PARMSPARMSPARMSPARM----SPGRRLEETDESQLERLYKPVFVLKPVS 1465
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
EGQ F+ +V G P P+ W+ +G I + +++ K+ + +L+I
Sbjct: 1466 FKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-------SLIIV 1518
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
DSG +T A N+ G S L V E
Sbjct: 1519 PATPSDSGEWTVVAQNRAGRSSISVILTVEAVE 1551
Score = 85.9 bits (211), Expect = 2e-16
Identities = 83/296 (28%), Positives = 127/296 (42%), Gaps = 44/296 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F ++L+ E G V L C + G P QV WY +G L + ++ N+ +L
Sbjct: 6174 PPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLK 6233
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIY-----------IEGVS-------SSDSEGD 369
I + +G+YSC ASN GT S+SA + I+ VS S+D E
Sbjct: 6234 ILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECH 6293
Query: 370 PNKEEMNRI--QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLD 427
+ RI K N+ P + V HL R+ + + S Q +
Sbjct: 6294 VTGAQPMRITWSKDNKEIRPGGNYTI--TCVGNTPHL----RILKVGKGDSGQYTCQATN 6347
Query: 428 --GKPIIAA-------PVFTKMLQ-NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIED 477
GK + +A P F K L+ + A +G+ + EC++ G+P KV W+R + + +
Sbjct: 6348 DVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHE 6407
Query: 478 SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
S + +M+ + L I E AEDSG + C A N G S L V+
Sbjct: 6408 SWKY--------NMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVK 6455
Score = 85.9 bits (211), Expect = 2e-16
Identities = 76/307 (24%), Positives = 119/307 (38%), Gaps = 42/307 (13%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
VT G+P C + G P WFKDG+++S ++H + SL I D G
Sbjct: 6656 VTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFI--NKVASLKIPCAEMSDKG 6713
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ N G+ +C+ + V +R P F
Sbjct: 6714 LYSFEVKNSVGKSNCTVSVHVS------------------------------DRIVPPSF 6743
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++ D+ A G L+C+VSG P + W +G ++ + E V +L +
Sbjct: 6744 IRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSE-NVCTLNLSL 6802
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
L D G Y C+A N G + S L+ V++ P + + V G + +
Sbjct: 6803 LEPSDTGIYTCVAANVAGSDECSAVLT-----VQEPPSFEQTPDSVEVLPGMSLTFTSVI 6857
Query: 1196 IGMPP-PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G PP V ++K E +P IS+ T +QP + D Y+ N+AG
Sbjct: 6858 RGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGD---YSCLVTNDAGS 6914
Query: 1255 VSCTARL 1261
SCT L
Sbjct: 6915 ASCTTHL 6921
Score = 85.1 bits (209), Expect = 4e-16
Identities = 98/451 (21%), Positives = 166/451 (36%), Gaps = 60/451 (13%)
Query: 193 QENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTP 252
QE + + R +V P + + V + KR ++ + + A T
Sbjct: 32642 QEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTET 32701
Query: 253 GSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG--IPPPQVRWYCEGKELE 310
+P+ P+ PP+ TQ L++ E + L C+V + +V WY +GK+L+
Sbjct: 32702 KPTPTEKVQHLPVSAPPKITQFLKAEASKEIAK--LTCVVESSVLRAKEVTWYKDGKKLK 32759
Query: 311 NSPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGD 369
+ A + L I E D G Y C S GT T+ + + S
Sbjct: 32760 ENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH---- 32815
Query: 370 PNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK 429
E++++I + + T S V P+A +
Sbjct: 32816 ---EKVSKISETKKSDQKTTESTVTRKTEPKAP--------------------------E 32846
Query: 430 PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
PI + PV LQ+ + S + F + G P P W ++G I +++ + K
Sbjct: 32847 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGG 32906
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANS 549
E I + DSG +TCT N G+VSS +L ++ +D S
Sbjct: 32907 FFLE--------IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTE-----AQKVS 32953
Query: 550 TTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFN---LPEDD 606
T + I PQ E S + L + +E +S ++ L+ + + E+
Sbjct: 32954 TQKTSEITPQKKAVVQEEIS-----QKALRSEEIKMSEAKSQEKLALKEEASKVLISEEV 33008
Query: 607 KGSEASS-EAGVVTTRQTRPDSFQERFNGQA 636
K S A+S E +V T+ E A
Sbjct: 33009 KKSAATSLEKSIVHEEITKTSQASEEVRTHA 33039
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/385 (25%), Positives = 159/385 (41%), Gaps = 73/385 (18%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GT 1001
+ P+F ++LK+ + EGS + + G P P + W K+ I +++ K+R EG G
Sbjct: 1554 VKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS-DIIVPHKYPKIRIEGTKGE 1612
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRIS--CSGHLMVQSL---PIRSRLTSAGQSHRGRS 1056
+L I+ST S D YT A N GR + C ++ V+ P R + G ++R +
Sbjct: 1613 AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRG-TYRAKE 1671
Query: 1057 RVQERDKEPLQERFFRPHFLQAPGDMVAHEG-------------RLCRL-----DCKVSG 1098
+ + EPL R+ + + + GD+ E RL R +C+++
Sbjct: 1672 -IAAPELEPLHLRYGQEQWEE--GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTP 1728
Query: 1099 LPPPELT--WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNS 1156
+ P + WL +G+P L A+ ++ E G SL RD+G C ATNK G +
Sbjct: 1729 IGDPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDH 1787
Query: 1157 FSLELSV--------------------------------------VAKEVKKAPVILEKL 1178
S L V ++ K+ P I+
Sbjct: 1788 TSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYP 1847
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ V EG R CRV G P P W + + I ++ R + D Y L I K
Sbjct: 1848 EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK-RFRVRYDGIHY--LDIVDCKS 1904
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDI 1263
D G ++A+N G++ +L+I
Sbjct: 1905 YDTGEVKVTAENPEGVIEHKVKLEI 1929
Score = 84.7 bits (208), Expect = 5e-16
Identities = 67/235 (28%), Positives = 97/235 (41%), Gaps = 16/235 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKI--VGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
P F K+L R+ P F C++ +G P V W DGK + N +M E G C
Sbjct: 1703 PFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANR-LRMINEF-GYC 1760
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL S D G T A N G S L+V+ + + +G R++E +
Sbjct: 1761 SLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELE 1820
Query: 1063 KEPL----------QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ Q+ +P + P + EG R C+V+G P P++ W LNGQ
Sbjct: 1821 RMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ- 1879
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
L S + VR G+H L I D G K A N G ++L + +E
Sbjct: 1880 -LIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRE 1933
Score = 84.3 bits (207), Expect = 7e-16
Identities = 76/282 (26%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 261 YEEPLGQPPRFTQKLRSREVPEGTRVQLDCIV--VGIPPPQVRWYCEGKELENSPDIHIV 318
Y++ Q P F +KL S + +C + +G P V W +GK LE + + ++
Sbjct: 1695 YDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI 1754
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--SDSEGDPNKEEMN 376
SL A+ D+G +C A+N YGTD TSA + ++ S +S+ ++ +
Sbjct: 1755 NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQ 1814
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ-QCQSPTNYLQGLDGKPIIAAP 435
RI++ + + H A V T Q + Q P I+ P
Sbjct: 1815 RIEE-----------------LERMAHEGALTGVTTDQKEKQKP----------DIVLYP 1847
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
++L EG+ F CRV G P PKV WY G LI S FR+ +
Sbjct: 1848 EPVRVL------EGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV---------RYD 1892
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
I L I + + D+G TA N G + +L ++ ED
Sbjct: 1893 GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRED 1934
Score = 84.3 bits (207), Expect = 7e-16
Identities = 81/336 (24%), Positives = 130/336 (38%), Gaps = 48/336 (14%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F K++++ S TF + G P + W KD QI +++ + D +L
Sbjct: 5048 PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDD-QILDEDDNVYISFV-DSVATL 5105
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I S + G YT A N G C L+VQ Q V +K+
Sbjct: 5106 QIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQE---------PAQIVEKAKSVDVTEKD 5156
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P+ L+C V+G P ++ WL +G+ ++P M
Sbjct: 5157 PMT------------------------LECVVAGTPELKVKWLKDGKQIVPSRYFSMSF- 5191
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
E V S I + ++D+G Y N G +S L V+ + + P +KL
Sbjct: 5192 ENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNI--PPSFTKKLTKMDKV 5249
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKSDAGW 1243
G + +EC+V G P W KD + I + + R+ H+ + L + + D
Sbjct: 5250 LGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVS---LEVNNLELEDTAN 5306
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
YT N AG +C+ L + + PP V+P
Sbjct: 5307 YTCKVSNVAGDDACSGILTV------KEPPSFLVKP 5336
Score = 84.0 bits (206), Expect = 9e-16
Identities = 77/306 (25%), Positives = 119/306 (38%), Gaps = 40/306 (13%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
VT G T CK+ G P V W+KDGK ++ +H + SL I S D G
Sbjct: 5715 VTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKH--KFSFYNKISSLRILSVERQDAG 5772
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT N G+ SC+ + V +R P F
Sbjct: 5773 TYTFQVQNNVGKSSCTAVVDVS------------------------------DRAVPPSF 5802
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
+ + G C L+CKV+G P + W ++ A ++ + V +L ++
Sbjct: 5803 TRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDN-VCTLQLNS 5861
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
L D G Y C+A N G + L+V ++ P +++ + V G V +
Sbjct: 5862 LDSSDMGNYTCVAANVAGSDECRAVLTV-----QEPPSFVKEPEPLEVLPGKNVTFTSVI 5916
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G PP W + + +R +++ + T A L + S +G YT N AG
Sbjct: 5917 RGTPPFKVNWFRGAREL-VKGDRCNIYFEDT-VAELELFNIDISQSGEYTCVVSNNAGQA 5974
Query: 1256 SCTARL 1261
SCT RL
Sbjct: 5975 SCTTRL 5980
Score = 83.6 bits (205), Expect = 1e-15
Identities = 85/320 (26%), Positives = 121/320 (37%), Gaps = 39/320 (12%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F L+ G V+ C++ G P V W+K ++ E+ T L
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVAT--L 6136
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+D G YT A N G S S+ R
Sbjct: 6137 VFNKVNINDSGEYTCKAENSIGTAS--------------------------SKTVFR--- 6167
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
+QER P F + D+ G L C+++G P ++ W +G +L D +
Sbjct: 6168 -IQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDG-VLLRDDENLQTSF 6225
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V +L I +G Y C A+N G S S L+ A+E KK+P K + V
Sbjct: 6226 VDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLT--AREPKKSPFFDIKPVSIDVI 6283
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G EC V G P W KDN+ I P I+ +T L I K D+G
Sbjct: 6284 AGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPH---LRILKVGKGDSGQ 6340
Query: 1244 YTLSAKNEAGIVSCTARLDI 1263
YT A N+ G C+A+L +
Sbjct: 6341 YTCQATNDVGKDMCSAQLSV 6360
Score = 83.6 bits (205), Expect = 1e-15
Identities = 78/283 (27%), Positives = 117/283 (41%), Gaps = 28/283 (9%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP FT+KL+ G+ V ++C V G PP V W+ EG E+ + N +LT
Sbjct: 7681 PPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALT 7740
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDP------NKEEMNRIQK- 380
+ E D+G Y+C A+N+ G+D SA + + S + DP I K
Sbjct: 7741 VNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKG 7800
Query: 381 --PNEVSSPPTTSAVIP--PAVPQAQHLVAQPRVATIQQCQSP--TNYLQGLDGKP---- 430
P VS +S ++P + VA+ + + QS T + GK
Sbjct: 7801 TPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTT 7860
Query: 431 --IIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
I AP F K L + S +G+ ++ E G P V W + G I +P R
Sbjct: 7861 HLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNG--INVTPSQRC---- 7914
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
++ E+ L I ED+G + C N G S AQ+
Sbjct: 7915 --NITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQI 7955
Score = 83.2 bits (204), Expect = 2e-15
Identities = 76/320 (23%), Positives = 127/320 (39%), Gaps = 44/320 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F R K G F C + G PV + W KDG +S + + L
Sbjct: 3551 PTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNW--RISDAENKHIL 3608
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ + T D G Y+ A+N G C L++
Sbjct: 3609 ELSNLTIQDRGVYSCKASNKFGADICQAELIIID-------------------------- 3642
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
+PHF++ + + + L+C+V +TW +GQ + P +K+
Sbjct: 3643 -------KPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICF- 3694
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
E + +L I +D+GTY C A+N+ G +S S ++V ++ P ++K+ +
Sbjct: 3695 EDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTV-----REPPSFVKKVDPSYLM 3749
Query: 1185 -EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G RL C++ G P W K+N+ + + M+ A L I K D+G
Sbjct: 3750 LPGESARLHCKLKGSPVIQVTWFKNNKELS-ESNTVRMYF-VNSEAILDITDVKVEDSGS 3807
Query: 1244 YTLSAKNEAGIVSCTARLDI 1263
Y+ A N+ G SC+ + I
Sbjct: 3808 YSCEAVNDVGSDSCSTEIVI 3827
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/120 (39%), Positives = 64/120 (53%), Gaps = 8/120 (6%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
+ P L+N++ EG+ V EC + G PSP V WYRE IE S DF+I +
Sbjct: 940 VTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ----- 994
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTT 551
I L+I E FAEDSG FTC+A N+ GTVS+ L V+ +E+ + + TT
Sbjct: 995 ---SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTT 1051
Score = 82.8 bits (203), Expect = 2e-15
Identities = 82/316 (25%), Positives = 129/316 (40%), Gaps = 31/316 (9%)
Query: 957 TEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGN 1016
+EG P F C++ G + KV W+ K+I K + +M + D T L I +D+G
Sbjct: 3357 SEGQPARFQCRVSGTDL-KVSWYSKDKKI-KPSRFFRMTQFED-TYQLEIAEAYPEDEGT 3413
Query: 1017 YTIMAANPQGRISCSGHLMVQSLP--IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
YT +A+N G++S + +L +++ + R+ + + V +R EPL+
Sbjct: 3414 YTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVAL---- 3469
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
G L + C++ P W G+ + S K +R + S L
Sbjct: 3470 ------------GHLAKFTCEIQSAPNVRFQWFKAGREIYE--SDKCSIRSSKYISSLEI 3515
Query: 1135 PLTQR-DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
TQ D G Y C A+N+ G S + L+V P L + ++ G + C
Sbjct: 3516 LRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAY---PPTFLSRPKSLTTFVGKAAKFIC 3572
Query: 1194 RVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
V G P W+KD + P RIS D L + D G Y+ A N+
Sbjct: 3573 TVTGTPVIETIWQKDGAALSPSPNWRIS---DAENKHILELSNLTIQDRGVYSCKASNKF 3629
Query: 1253 GIVSCTARLDIYAQWH 1268
G C A L I + H
Sbjct: 3630 GADICQAELIIIDKPH 3645
Score = 82.0 bits (201), Expect = 3e-15
Identities = 79/338 (23%), Positives = 131/338 (38%), Gaps = 46/338 (13%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L PR T ++RS VP G + V P +V+WY G EL+ S IH +
Sbjct: 32370 LDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVL 32429
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN-- 382
+L I + +D+G Y +N G S A + + G + EE+ R P
Sbjct: 32430 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT 32489
Query: 383 -----EVSSPPTTSAV-IPPAVPQAQHLVAQPR--VATIQQCQSPTNYLQGLDGKPI--- 431
VSS TS + +V + + + + R +++ + S L+ K +
Sbjct: 32490 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 32549
Query: 432 ---------IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+AA + TK ++++ EG+ F C G P P V W R+G ++ S +
Sbjct: 32550 STTRKIKTTLAARILTKP-RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ 32608
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ K +S T I+ V A D G ++ N G ++
Sbjct: 32609 VTTTKYKS--------TFEISSVQASDEGNYSVVVENS------------EGKQEAEFTL 32648
Query: 543 SLHSANSTTNLAAIEPQ---PSPPHSEPPSVEQPPKPK 577
++ A T P+ P P P +V+ P + K
Sbjct: 32649 TIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 32686
Score = 81.6 bits (200), Expect = 4e-15
Identities = 69/301 (22%), Positives = 129/301 (42%), Gaps = 50/301 (16%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP F Q S EV G + ++ G PP +V+W+ +EL +I + L
Sbjct: 6832 EPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTEL 6891
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--------SDSEGDPNKEEMNRI 378
+ E ++G YSC +N G+ S + ++++ ++ S G P +
Sbjct: 6892 ELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVETGSPI------V 6945
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT----------NYLQ---- 424
+ +PP + + I + ++L++Q +I + T +Y Q
Sbjct: 6946 LEATYTGTPPISVSWI-----KDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCL 7000
Query: 425 --GLDGKPIIAA-------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLI 475
G+ I A P F + L+++ A G+ +C+V G P ++ WY+E T +
Sbjct: 7001 IENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKL 7060
Query: 476 EDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGN 535
+P +++ K + +LVI +V D G ++C A N G V+S A L ++
Sbjct: 7061 RSAPAYKMQFK--------NNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKAR 7112
Query: 536 E 536
+
Sbjct: 7113 K 7113
Score = 80.5 bits (197), Expect = 1e-14
Identities = 83/336 (24%), Positives = 126/336 (37%), Gaps = 47/336 (13%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F K+L G V + G V W KD ++ + +E+ ++ D +L
Sbjct: 6551 PRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFI-DNIATL 6609
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ S + + G Y N G CS L V E
Sbjct: 6610 QLGSPEASNSGKYICQIKNDAGMRECSAVLTVL--------------------------E 6643
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P + ++ P M G L+C V+G P W +G+ + D+ H +
Sbjct: 6644 PAR-------IIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFI 6696
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V SL I D G Y N G+++ ++ + V + V P + KL++
Sbjct: 6697 NK-VASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVP--PSFIRKLKDVNAI 6753
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKD-NETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G V LECRV G P W +D NE + + + S ++ L++P SD G
Sbjct: 6754 LGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEP---SDTGI 6810
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
YT A N AG C+A L + Q PP P
Sbjct: 6811 YTCVAANVAGSDECSAVLTV------QEPPSFEQTP 6840
Score = 79.7 bits (195), Expect = 2e-14
Identities = 76/321 (23%), Positives = 122/321 (38%), Gaps = 45/321 (14%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
+P F K K V + V ++ G P ++ WFKD + ++ + D S
Sbjct: 4392 SPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQ--DHLVS 4449
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + D G Y N G CS + + +
Sbjct: 4450 LQILKFVAADAGEYQCRVTNEVGSSICSARVTL--------------------------R 4483
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
EP P F++ + G + G P +TWL + + D + +M
Sbjct: 4484 EP-------PSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTF 4536
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGV 1183
E V SL + + + G Y C A N G S LSV K+ I E+ + V
Sbjct: 4537 -ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSV-----KEPATITEEAVSIDV 4590
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPC-TRERISMHQDTTGYACLLIQPAKKSDAG 1242
+G P L+ + G W KD + + ++ +IS+ T + L I +K D+G
Sbjct: 4591 TQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISV---TDTVSILKIISTEKKDSG 4647
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
YT +N+ G SC AR+++
Sbjct: 4648 EYTFEVQNDVGRSSCKARINV 4668
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/289 (23%), Positives = 112/289 (38%), Gaps = 46/289 (15%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP F ++ EV G V ++ G PP +V W+ +EL +I + L
Sbjct: 5891 EPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAEL 5950
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS-----SDSEGDPNKE-------- 373
+ +G Y+C SN G S + ++++ ++ SD +P K
Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYT 6010
Query: 374 --------------EMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP 419
+ +K N V++ T I L + R A C+
Sbjct: 6011 GTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEI---------LNSTKRDAGQYSCEIE 6061
Query: 420 TNYLQGLDGKPI--IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIED 477
+ + G + + P F L+ L A+ G V +C+V G P V WY+ T +
Sbjct: 6062 NEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRP 6121
Query: 478 SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSS 526
+P++R + TLV +V DSG +TC A N GT SS
Sbjct: 6122 TPEYRTY--------FTNNVATLVFNKVNINDSGEYTCKAENSIGTASS 6162
Score = 79.0 bits (193), Expect = 3e-14
Identities = 93/374 (24%), Positives = 153/374 (40%), Gaps = 67/374 (17%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
A P F + LQ+++ +G V + RV G P+P V++YR+G I+ S DF+I Q+
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQE------ 155
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED--------LSNNGSL 544
++ +L+IAE + EDSG ++ A+N G +S A+L V+G E+ + + +
Sbjct: 156 --GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213
Query: 545 HSANST------------TNLAAIE------PQPSPPHSEPPSVEQPPKPKLE-----GV 581
+ T ++A +E PH PP + PPKPK +
Sbjct: 214 SESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRI--PPKPKSRSPTPPSI 271
Query: 582 LVNHNEPRSSSRIGLR------VHFNLPEDDKGSEASSEAGVVTT--RQTRPDSFQERFN 633
R S +R H P S A + T+ R R +
Sbjct: 272 AAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQ 331
Query: 634 GQATKT-PEPSSPVKEPPPVLAKPKLDS-----TQLQQLHNQVLLE-QHQLQNPPP-SSP 685
T PE P K+ V + + + T Q+ + E ++ +Q S
Sbjct: 332 ASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGA 391
Query: 686 KEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVF 745
S++ S A AV T +K+VK + ++ ++A T A +A PV
Sbjct: 392 AGAAASVSASASYAAEAVATGAKEVKQDADKSAAVA--------TVVAAVDMARVREPV- 442
Query: 746 TLSSTPQTIQRTVS 759
+S+ QT QRT +
Sbjct: 443 -ISAVEQTAQRTTT 455
Score = 79.0 bits (193), Expect = 3e-14
Identities = 77/306 (25%), Positives = 119/306 (38%), Gaps = 46/306 (15%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
S V F + G P K+ WFKD ++ C + EG T L++ S + G YT
Sbjct: 5345 STVEFKAILKGTPPFKIKWFKDDVELVS-GPKCFIGLEGS-TSFLNLYSVDASKTGQYTC 5402
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
N G SC+ L+V P + A +
Sbjct: 5403 HVTNDVGSDSCTTMLLVTEPPKFVKKLEASK----------------------------- 5433
Query: 1080 GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
+ G RL+CK++G P + W N + LP + + V + ++ L+
Sbjct: 5434 ---IVKAGDSSRLECKIAGSPEIRVVWFRN-EHELPASDKYRMTFIDSVAVIQMNNLSTE 5489
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
D+G + C A N G S S ++ V V P I+E L+N V LEC + G
Sbjct: 5490 DSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNA------EVSLECELSGT 5543
Query: 1199 PPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSC 1257
PP W KD + +++ +I+ T L + SD G Y A+NE G +C
Sbjct: 5544 PPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVD---TSDIGEYHCKAQNEVGSDTC 5600
Query: 1258 TARLDI 1263
+ +
Sbjct: 5601 VCTVKL 5606
Score = 78.6 bits (192), Expect = 4e-14
Identities = 85/366 (23%), Positives = 128/366 (34%), Gaps = 56/366 (15%)
Query: 925 VDESDDEIQH----DEIPTGKCIA-------PIFDKRLKHFRVTEGSPVTFTCKIVGIPV 973
VD SD H +E+ + C+ P F +L V G P I G
Sbjct: 5579 VDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQP 5638
Query: 974 PKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGH 1033
V W K+ +++ + +E+ ++ + +L + G Y N G
Sbjct: 5639 IFVQWLKEKEEVIRESENIRITFV-ENVATLQFAKAEPANAGKYICQIKNDGGMRENMAT 5697
Query: 1034 LMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLD 1093
LMV + ++ G M G C L+
Sbjct: 5698 LMVLEPAV---------------------------------IVEKAGPMTVTVGETCTLE 5724
Query: 1094 CKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTG 1153
CKV+G P + W +G+ + HK + SL I + ++DAGTY N G
Sbjct: 5725 CKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNK-ISSLRILSVERQDAGTYTFQVQNNVG 5783
Query: 1154 QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIP 1213
++S + + V + V P +L+N G G LEC+V G P W + I
Sbjct: 5784 KSSCTAVVDVSDRAV--PPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIV 5841
Query: 1214 CTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
+ + D L + SD G YT A N AG C A L + Q PP
Sbjct: 5842 SGAKYQTTFSDNV--CTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTV------QEPP 5893
Query: 1274 PMSVRP 1279
P
Sbjct: 5894 SFVKEP 5899
Score = 78.2 bits (191), Expect = 5e-14
Identities = 63/231 (27%), Positives = 93/231 (40%), Gaps = 16/231 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P LK+ V EG VT C I G P P V W+++ QI + G L
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDF--QITFQSGIARL 1000
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ--------SLPIRSRLTSAGQSHRGRS 1056
I ++D G +T A N G +S S +L VQ + + + T+ +
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060
Query: 1057 RVQERDKEPLQERF-----FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQ 1111
V D +E+ P+F+ P EG C+V G P P + W +G
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120
Query: 1112 PVLPDASHKMLV-RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P+ +K+ ++TG L+I DAG Y + NK G+ S S L
Sbjct: 1121 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 77.8 bits (190), Expect = 6e-14
Identities = 70/281 (24%), Positives = 114/281 (40%), Gaps = 35/281 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSL 326
P F +KL++ + EG+R+++ G P P + W + P I I +L
Sbjct: 1556 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1615
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I +D+ Y+ A N G D+T ++ +E V ++ E
Sbjct: 1616 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE-VEFAEPE------------------- 1655
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-LDGKPIIAAPVFTKMLQNLS 445
P +IP +A+ + A P + + + +G L K P F K L +L
Sbjct: 1656 -PERKLIIPRGTYRAKEIAA-PELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1713
Query: 446 ASEGQLVVFECRVK--GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
FECR+ G P+ VEW +G +E + R++ + C+L
Sbjct: 1714 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFG--------YCSLDYG 1765
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSL 544
++ DSG TC A+NKYGT + A L V+ + L L
Sbjct: 1766 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQL 1806
Score = 76.3 bits (186), Expect = 2e-13
Identities = 70/296 (23%), Positives = 123/296 (41%), Gaps = 28/296 (9%)
Query: 257 SSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIH 316
+S E + +PP F ++L+ EV + + V+L+C V G PP +V W +E+ +S
Sbjct: 4943 ASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYT 5002
Query: 317 IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--SDSEGDPNKEE 374
+ ++ +L I + DTG Y C SN G+ S S + ++ S E +
Sbjct: 5003 LTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLK 5062
Query: 375 MNRIQKPNEVSSPPTTSAVIPP----AVPQAQHLVAQPRVATIQ------------QCQS 418
+ + SPP + + ++ VAT+Q CQ+
Sbjct: 5063 SSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQA 5122
Query: 419 PT-NYLQGLDGKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIE 476
+ ++ ++ P + +++ +E + EC V G P KV+W ++G I
Sbjct: 5123 KNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIV 5182
Query: 477 DSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
S F SM+ + + I V +DSG +T N +G+ S A L V
Sbjct: 5183 PSRYF--------SMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV 5230
Score = 75.9 bits (185), Expect = 2e-13
Identities = 68/287 (23%), Positives = 111/287 (38%), Gaps = 29/287 (10%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP FT+KL+ + +G+ + L+CIV G P ++W+ + +E+ S N L
Sbjct: 4674 PPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLE 4733
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEI-------YIEGVSSSDSE-----------GD 369
I++ D+G Y+C A+N G + S + ++E S D G
Sbjct: 4734 ISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGG 4793
Query: 370 PNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK 429
+ + E+ S S + A+ + CQ +
Sbjct: 4794 TAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKA 4853
Query: 430 PIIA--APVFTKMLQN-LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
+ P F K L GQ FEC++ G P +V WY +G + +QK
Sbjct: 4854 TLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGN------EITAIQK 4907
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
S + + T I+ E+SG + C A N GT S +L V+
Sbjct: 4908 HGISFI--DGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVK 4952
Score = 75.5 bits (184), Expect = 3e-13
Identities = 68/265 (25%), Positives = 100/265 (37%), Gaps = 63/265 (23%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L+ EG + C V G +V WY + K+++ S + Q + + L
Sbjct: 3344 PPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLE 3402
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
IAEA+ ED G Y+ ASN G S++A + +E S E + EM E+ +
Sbjct: 3403 IAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEM-------EMKAA 3455
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSAS 447
P I P L +
Sbjct: 3456 PVIKRKIEP-----------------------------------------------LEVA 3468
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
G L F C ++ AP+ + +W++ G I +S I K I +L I
Sbjct: 3469 LGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSK--------YISSLEILRTQV 3520
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHV 532
D G +TC ASN+YG+VS A L V
Sbjct: 3521 VDCGEYTCKASNEYGSVSCTATLTV 3545
Score = 75.1 bits (183), Expect = 4e-13
Identities = 80/347 (23%), Positives = 125/347 (36%), Gaps = 70/347 (20%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H L A E + A+ G DT GS L PPRF +KL G
Sbjct: 7457 HILNVDAADIGEYQCKATNDVGSDTCVGSIA--------LKAPPRFVKKLSDISTVVGKE 7508
Query: 286 VQLDCIVVGIPPPQVRWYCE-GKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
VQL + G P V W+ + G+ + S +I I + N+ +L + + G+Y+C
Sbjct: 7509 VQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIK 7568
Query: 345 NIYGT---------------------------DSTSAEIYIEGVSSSDSEGDPNKEEM-- 375
N G D+ + E + G ++ + +E+
Sbjct: 7569 NDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTS 7628
Query: 376 ---------NRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL 426
N++ ++ P+ S V V Q+ V + Q T
Sbjct: 7629 DNKYKISFFNKVSGLKIINVAPSDSGVYSFEV---QNPVGKDSCTASLQVSDRT------ 7679
Query: 427 DGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
P FT+ L+ + G VV EC+V G+P V W+ EG I ++
Sbjct: 7680 ------VPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQ---- 7729
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ C L + + DSG +TC A+N G+ A L VR
Sbjct: 7730 ----TTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVR 7772
Score = 75.1 bits (183), Expect = 4e-13
Identities = 70/297 (23%), Positives = 126/297 (42%), Gaps = 43/297 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F +L + G +C V G P +V W + +E+ + I N LT
Sbjct: 8152 PPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLT 8211
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE------------GVSSSDSEGDPNKEEM 375
+ + + D+G+Y+C+A N G DS +A++ I+ + ++EG+ K E
Sbjct: 8212 VLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLE- 8270
Query: 376 NRI--QKP-------NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL 426
R+ +P N + PT++ I + LV Q R A + T +
Sbjct: 8271 GRVAGSQPITVAWYKNNIEIQPTSNCEI---TFKNNTLVLQVRKAGMNDAGLYTCKVSND 8327
Query: 427 DGKPIIAA----------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIE 476
G + + PVF + L ++ SEG+ V C V+G+ +++W + G I+
Sbjct: 8328 AGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIK 8387
Query: 477 DSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
S S + L + +V DSG + C ASN G+ ++ +++ ++
Sbjct: 8388 PSDRC--------SFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIK 8436
Score = 75.1 bits (183), Expect = 4e-13
Identities = 83/355 (23%), Positives = 139/355 (39%), Gaps = 50/355 (14%)
Query: 820 TSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNT--KSPQPVNDDNIR 877
T I +P+ S V+ P P AP P+ K++ + +P D
Sbjct: 30803 TFGISDPLEVSSVVIIKSPFEKP--------GAPGKPTITAVTKDSCVVAWKPPASDGGA 30854
Query: 878 ETKNAVIRDLGKK------ITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDE 931
+ +N + KK +T ++R + + + + + L E + E + E
Sbjct: 30855 KIRNYYLEKREKKQNKWISVTTEEIR--ETVFSVKNLIEGLEYEFRVKCENLGGESEWSE 30912
Query: 932 IQHDEIPTGKCI--APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRN 989
I P AP F + L++ V S T CK+ G P P V W++ GK+I
Sbjct: 30913 ISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 30972
Query: 990 EHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG 1049
+++ G L I S T DD Y + A N G +S + L V+ +P + L
Sbjct: 30973 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHL---- 31027
Query: 1050 QSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
P L+ G + A G + + SG P P +TW
Sbjct: 31028 -----------------------PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITW-QK 31063
Query: 1110 GQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
GQ ++ + H ++ SL+ + + ++DAG Y A N+ G + ++EL V
Sbjct: 31064 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 31118
Score = 74.3 bits (181), Expect = 7e-13
Identities = 64/238 (26%), Positives = 107/238 (44%), Gaps = 37/238 (15%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP K +K G +C+IVG P+P + W++ GK++ + ++ KM +G T +
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKY-KMSSDG-RTHT 30589
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L + + +D+G YT +A N G + S L++Q+ P Q H G
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP---------QFHPG--------- 30631
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
PL+E+++ G RL G P P +TW +GQ +L + S + +
Sbjct: 30632 YPLKEKYY------------GAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQN-SENITI 30677
Query: 1124 RETGVHSLLIDPLTQR--DAGTYKCIATNKTGQNSFSLELSVVAKEVK-KAPVILEKL 1178
T ++ L+ QR AG YK +N G L++ + K K P+++E L
Sbjct: 30678 ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 30735
Score = 74.3 bits (181), Expect = 7e-13
Identities = 79/326 (24%), Positives = 123/326 (37%), Gaps = 44/326 (13%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + + + EG V FTC+I G P P++ WFK+ IS + R S
Sbjct: 33133 APAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR--NVYS 33190
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL---PIRSRL--TSAGQSHRGRSRV 1058
L I + + D G YTI A N +G+ S + LMV L P R + TS S +G
Sbjct: 33191 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSS 33250
Query: 1059 QE-RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA 1117
Q + QE F + M + K + + ++ +
Sbjct: 33251 QSVQMSASKQEASFSSFSSSSASSMT---------EMKFASMSAQSMS-----------S 33290
Query: 1118 SHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEK 1177
+ V + + I +TQ ++ T K + G + +++ P
Sbjct: 33291 MQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG----------IPPKIEALP----- 33335
Query: 1178 LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAK 1237
+ + EG + + C G P P W I + ++T L+I +
Sbjct: 33336 -SDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 33394
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
K D G YTLS NE G S T + I
Sbjct: 33395 KQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 73.9 bits (180), Expect = 9e-13
Identities = 78/336 (23%), Positives = 129/336 (38%), Gaps = 48/336 (14%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H L + + E A+ G DT S+ ++EP PRF +KL G
Sbjct: 6516 HILNLEASDVGEYHCKATNEVGSDTCS----CSVKFKEP----PRFVKKLSDTSTLIGDA 6567
Query: 286 VQLDCIVVGIPPPQVRWYCE-GKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
V+L IV G P V W + G+ + S + I N+ +L + ++G+Y C
Sbjct: 6568 VELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIK 6627
Query: 345 NIYGTDSTSA---------------------------EIYIEGVSSSDSEGDPNKEEMNR 377
N G SA E + G ++ + E++
Sbjct: 6628 NDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSA 6687
Query: 378 IQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVF 437
K + S IP A + L + ++ +N + I P F
Sbjct: 6688 DSKHHITFINKVASLKIPCAEMSDKGLYS----FEVKNSVGKSNCTVSVHVSDRIVPPSF 6743
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
+ L++++A G VV ECRV G+ V W+++G I P + + E +
Sbjct: 6744 IRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQ--------SSFSENV 6795
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
CTL ++ + D+G +TC A+N G+ A L V+
Sbjct: 6796 CTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQ 6831
Score = 73.9 bits (180), Expect = 9e-13
Identities = 79/334 (23%), Positives = 129/334 (38%), Gaps = 45/334 (13%)
Query: 941 KCIAPIFDKRLKH-FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD 999
+ I P F KRL TEG+ ++ G V W+K+ +I + +C++ + +
Sbjct: 8245 RLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS-NCEITFKNN 8303
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
T L + +D G YT +N G C+ +++
Sbjct: 8304 -TLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVI----------------------- 8339
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASH 1119
KEP + F H + EG +L C V G P + WL G+ + P +
Sbjct: 8340 ---KEPKKPPVFDQHLTP----VTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKP-SDR 8391
Query: 1120 KMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-----VAKEVKKAPV- 1173
+G L + + + D+G Y C A+N G ++ ++++ VA KKA V
Sbjct: 8392 CSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVD 8451
Query: 1174 ----ILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+ + Q+ V E +V G P P W K R+ +HQ A
Sbjct: 8452 GRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQ-KGDEA 8510
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L I+ K+D+G Y A NE G + L +
Sbjct: 8511 KLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544
Score = 73.9 bits (180), Expect = 9e-13
Identities = 57/210 (27%), Positives = 90/210 (42%), Gaps = 8/210 (3%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA-SHKMLVRETGVHSL 1131
PHF + ++ L CKV+G P P + W G+ ++ D +++ + G H L
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 30987
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
+I +T DA Y+ ATN+ G S + L V P LE + G V +
Sbjct: 30988 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 31047
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ G P PV W+K + I + + + + ++ DAG+Y + AKN
Sbjct: 31048 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 31106
Query: 1252 AGIVSCTARLDIYAQWHHQIP-PPMSVRPS 1280
GI T LD+ +P PP V+ S
Sbjct: 31107 FGIDQKTVELDV-----ADVPDPPRGVKVS 31131
Score = 73.2 bits (178), Expect = 2e-12
Identities = 61/287 (21%), Positives = 117/287 (40%), Gaps = 29/287 (10%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F K S ++ G C V G P ++ W + +E+ + + N +LT
Sbjct: 7211 PPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLT 7270
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK----EEMNRIQ---- 379
+ + + D G+Y+C+ASNI G DS SA++ ++ + +P++ +E R +
Sbjct: 7271 VLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIG 7330
Query: 380 -KPN------------EVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL 426
P + SS S V AV + +L + + +
Sbjct: 7331 GSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSS 7390
Query: 427 DGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
+ P+F K + +G V EC ++G P V WY++ + ++I+ +
Sbjct: 7391 TSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSE 7450
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ ++ I V A D G + C A+N G+ + + + ++
Sbjct: 7451 --------NFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALK 7489
Score = 72.8 bits (177), Expect = 2e-12
Identities = 64/237 (27%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
M +EG+ L ++G ++ W+LNG + ++ V + +L I + RD
Sbjct: 33048 MSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 33104
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPP 1201
G CI+ K G +L++ +KE+ AP + + ++ + EG V C + G P P
Sbjct: 33105 GILTCISKTKEGIVKCQYDLTL-SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 33163
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
W K+N I + +S+ + Y+ L I+ A SD+G YT+ AKN G S TA L
Sbjct: 33164 EIEWFKNNLPISIS-SNVSISRSRNVYS-LEIRNASVSDSGKYTIKAKNFRGQCSATASL 33221
Query: 1262 DIYAQWHHQIPPPMSVRPSG--SRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVE 1316
+ + + +R SG S GS +S+ + + ++ + S S+ S+ E
Sbjct: 33222 -MVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTE 33277
Score = 72.0 bits (175), Expect = 4e-12
Identities = 65/289 (22%), Positives = 120/289 (41%), Gaps = 33/289 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F + +S G + C V G P + W +G L SP+ I A N H L
Sbjct: 3550 PPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILE 3609
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNR-------IQK 380
++ +D G YSC ASN +G D AE+ I E +P + +N+ + +
Sbjct: 3610 LSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDE 3669
Query: 381 PNEVS-SPPTTSAVIPPAVPQAQHLVAQPRVATIQ----QCQSPTNYLQGLDGK------ 429
+V+ + +PP + + + ++AT++ + + Y+ +
Sbjct: 3670 DRKVTVTWSKDGQKLPPG--KDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSC 3727
Query: 430 ----PIIAAPVFTKMLQ-NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P F K + + G+ C++KG+P +V W++ + +S R+
Sbjct: 3728 SATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMY 3787
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
++ L I +V EDSG ++C A N G+ S ++ ++
Sbjct: 3788 FVNSEAI--------LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIK 3828
Score = 72.0 bits (175), Expect = 4e-12
Identities = 71/294 (24%), Positives = 117/294 (39%), Gaps = 37/294 (12%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F+++LR + G V DC + G P V WY +GK L++SP++ N +L
Sbjct: 8056 PPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLN 8115
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSA-------------EIYIEGVSSSDSEGDPNKEE 374
I + G+YSC A+N G+ S+SA +I + V + E +
Sbjct: 8116 IFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECH 8175
Query: 375 MNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP----TNYLQGLDGKP 430
+ Q P +VS + + Q +L + ++ + T Y GK
Sbjct: 8176 VTGTQ-PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKD 8234
Query: 431 IIAA----------PVFTKML-QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
A P FTK L + + +EG E RV G+ V WY+ I+ +
Sbjct: 8235 SCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTS 8294
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ I K L + + D+G +TC SN G+ + + ++
Sbjct: 8295 NCEITFK--------NNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIK 8340
Score = 71.6 bits (174), Expect = 5e-12
Identities = 67/300 (22%), Positives = 115/300 (38%), Gaps = 55/300 (18%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP FT+KL + G+ + ++C V G P +W+ +GKE+ S +V SL
Sbjct: 5236 PPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLE 5295
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
+ EDT Y+C SN+ G D+ S + + KE + + KP +
Sbjct: 5296 VNNLELEDTANYTCKVSNVAGDDACSGILTV-------------KEPPSFLVKPGRQQAI 5342
Query: 388 PTTS----AVIPPAVP-------QAQHLVAQPRVATIQQCQSPTNYLQGLDGKP------ 430
P ++ A++ P LV+ P+ + + L +D
Sbjct: 5343 PDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTC 5402
Query: 431 ----------------IIAAPVFTKMLQ-NLSASEGQLVVFECRVKGAPSPKVEWYREGT 473
+ P F K L+ + G EC++ G+P +V W+R
Sbjct: 5403 HVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEH 5462
Query: 474 LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ S +R M + + + + + EDSG F C A N G+ S ++ V+
Sbjct: 5463 ELPASDKYR--------MTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVK 5514
Score = 71.2 bits (173), Expect = 6e-12
Identities = 65/289 (22%), Positives = 119/289 (41%), Gaps = 31/289 (10%)
Query: 267 QPPRFTQKL-RSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
+PP F K R + +P+ T V+ I+ G PP +++W+ + EL + P I G+
Sbjct: 5328 EPPSFLVKPGRQQAIPDST-VEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSF 5386
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDS-------TSAEIYIEGVSSSD--SEGDPNKEEMN 376
L + TG+Y+C +N G+DS T +++ + +S GD ++ E
Sbjct: 5387 LNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECK 5446
Query: 377 RIQKP--------NEVSSPPT----TSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
P NE P + + + AV Q +L + I + Q+P
Sbjct: 5447 IAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTS 5506
Query: 425 GLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ PVF+ + + V EC + G P +V WY++ + S ++I
Sbjct: 5507 CSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIA 5566
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
K + ++ I V D G + C A N+ G+ + + + ++
Sbjct: 5567 SKNFHT--------SIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLK 5607
Score = 70.1 bits (170), Expect = 1e-11
Identities = 68/293 (23%), Positives = 115/293 (39%), Gaps = 31/293 (10%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P F ++L V G+ + L+ G PP V W + + S I L
Sbjct: 6925 EPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTIL 6984
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEI-------YIEGVSSSDSE-GDPNKEEMNRI 378
I E+ ED +YSC N G D A + +IE + ++ G+P +
Sbjct: 6985 EILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVD 7044
Query: 379 QKPNEVSS---PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQ------SPTNYLQGLDGK 429
P S T P Q ++ VA + + N + +
Sbjct: 7045 GTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASS 7104
Query: 430 PIIAA------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
++ P F + L+++ + G V FECR+ G+ +V WY++G L++D + +
Sbjct: 7105 AVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQ- 7163
Query: 484 LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ + TL I + G + C+ASN GT SS A+L + +E
Sbjct: 7164 -------TSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHE 7209
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/115 (32%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 938 PTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE 997
PT + P+F + L + EG V F ++ GIP P + W KDG+ +S + ++ E
Sbjct: 31788 PTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLS-LGPNIEIIHE 31846
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSH 1052
G +LHI T +D G Y + A N G SC HL V+ L + + + + H
Sbjct: 31847 GLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEH 31901
Score = 69.3 bits (168), Expect = 2e-11
Identities = 81/363 (22%), Positives = 133/363 (36%), Gaps = 72/363 (19%)
Query: 218 DTRDNEVNHALEQQEAKRR-EAEQAASEAAGGDTTPGSSPSSLYYEE-------PLGQPP 269
DT E+ A + E A A + + +P S+ +E + P
Sbjct: 3397 DTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAP 3456
Query: 270 RFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIA 329
+K+ EV G + C + P + +W+ G+E+ S I + + SL I
Sbjct: 3457 VIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEIL 3516
Query: 330 EAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPT 389
D G Y+C ASN YG+ S +A + + +E P P +S P +
Sbjct: 3517 RTQVVDCGEYTCKASNEYGSVSCTATLTV-------TEAYP----------PTFLSRPKS 3559
Query: 390 TSAVIPPAVPQAQHLVAQPRVATIQQ------CQSPTNYLQGLDGKP------------- 430
+ + A + P + TI Q SP + + K
Sbjct: 3560 LTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRG 3619
Query: 431 --------------------IIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYR 470
II P F K L+ + ++ + V EC+V V W +
Sbjct: 3620 VYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSK 3679
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+G + D++I + ++I TL I +DSG + CTASN+ G+ S A +
Sbjct: 3680 DGQKLPPGKDYKICFE--------DKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATV 3731
Query: 531 HVR 533
VR
Sbjct: 3732 TVR 3734
Score = 68.6 bits (166), Expect = 4e-11
Identities = 76/309 (24%), Positives = 132/309 (42%), Gaps = 42/309 (13%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S ++LY E + F + ++ +V E R +C V P V+W + +EL+ +
Sbjct: 3046 TSTATLYVE---ARHIEFRKHIKDIKVLEKKRAMFEC-EVSEPDITVQWMKDDQELQITD 3101
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
I I + +H L I D G+Y+ A G + ++A++++EG D K+
Sbjct: 3102 RIKIQKEKYVHRLLIPSTRMSDAGKYTVVA----GGNVSTAKLFVEG---RDVRIRSIKK 3154
Query: 374 EMNRIQKPNEVSSPPTTSAVIPP-----------AVPQAQHLVAQPRV------ATIQQC 416
E+ I+K V + V + V + R+ T Q
Sbjct: 3155 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSD 3214
Query: 417 QSPTNYLQGLDGKPI---IAAPVFTKMLQNL---SASEGQLVVFECRVKGAPSPKVEWYR 470
++ G + + + AP ++LQ L + G+ F + G P PK+ WY+
Sbjct: 3215 AGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYK 3274
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
E L+ S F K + + + +E TL++ E F ED+ +TC A N YG ++ A L
Sbjct: 3275 EEQLL--STGF-----KCKFLHDGQEY-TLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3326
Query: 531 HVRGNEDLS 539
V E +S
Sbjct: 3327 SVEVPEVVS 3335
Score = 68.6 bits (166), Expect = 4e-11
Identities = 64/282 (22%), Positives = 109/282 (38%), Gaps = 42/282 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F +KL+ G V L+C V G P V W+ +G E+ + P + N+ +L
Sbjct: 6740 PPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLN 6799
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-------------- 373
++ DTG Y+C A+N+ G+D SA + ++ S + D +
Sbjct: 6800 LSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRG 6859
Query: 374 ----EMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQC--------QSPTN 421
++ + E+ + + + V + + QP + C S T
Sbjct: 6860 TPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTT 6919
Query: 422 YLQGLDGKPIIAAP-VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
+L + P F K L + S G +V E G P V W ++ +
Sbjct: 6920 HL-------FVKEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKD--------E 6964
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ I Q + S+ E+ L I E ED ++C N+ G
Sbjct: 6965 YLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAG 7006
Score = 68.2 bits (165), Expect = 5e-11
Identities = 70/293 (23%), Positives = 115/293 (39%), Gaps = 32/293 (10%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE-LENSPDIHIVQAGNL 323
L +PPRF KL S V G +L + G P V+W E +E + S +I I N+
Sbjct: 5606 LKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENV 5665
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI-EGVSSSDSEGDPNKEEMNRIQKPN 382
+L A+A + G+Y C N G A + + E + G
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLEC 5725
Query: 383 EVSSPPTTSA-------VIPPAVPQA---QHLVAQPRVATI--QQCQSPTNYLQGLDGKP 430
+V+ P S ++ + + ++ R+ ++ Q + T +Q GK
Sbjct: 5726 KVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKS 5785
Query: 431 IIAA----------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
A P FT+ L+N G + EC+V G+ V W+ E T I
Sbjct: 5786 SCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAK 5845
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
++ + +CTL + + + D G +TC A+N G+ A L V+
Sbjct: 5846 YQ--------TTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQ 5890
Score = 67.4 bits (163), Expect = 9e-11
Identities = 64/287 (22%), Positives = 111/287 (38%), Gaps = 43/287 (14%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP F +K+ S G + G P V W + E+ +I + N+
Sbjct: 4482 LREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVA 4541
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI--------EGVSSSDSEGDP------ 370
SL ++ + G+Y C A N G SA + + E VS ++GDP
Sbjct: 4542 SLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVK 4601
Query: 371 ---NKEEMNRIQKPNE---------VSSPPTTSA---VIPPAVPQAQHLVAQPRVATIQQ 415
KE + K + +S T S + ++
Sbjct: 4602 FSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSS 4661
Query: 416 CQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLI 475
C++ N L +I P FTK L+ + + +G + EC V G+ ++W+++ I
Sbjct: 4662 CKARINVLD------LIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEI 4715
Query: 476 EDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
S ++ + + L I+++ DSG +TC+A+NK G
Sbjct: 4716 SASEKYK--------FSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754
Score = 67.4 bits (163), Expect = 9e-11
Identities = 68/277 (24%), Positives = 106/277 (38%), Gaps = 68/277 (24%)
Query: 257 SSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIH 316
SS+ +EP +PP F Q L V EG VQL C V G P +++W G+E++ S
Sbjct: 8335 SSIVIKEPK-KPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCS 8393
Query: 317 IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMN 376
A L + + + D+G Y C ASN+ G+D+T +++ I+
Sbjct: 8394 FSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIK----------------- 8436
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPV 436
KP + PA +A +DG+
Sbjct: 8437 --DKP-----------AVAPATKKA-----------------------AVDGRLF----- 8455
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE- 495
F Q++ E F +V G P P V+W + +R L + R +
Sbjct: 8456 FVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTK--------GKWRQLNQGGRVFIHQKG 8507
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ L I + DSG + C A N++G + S L V
Sbjct: 8508 DEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQV 8544
Score = 67.0 bits (162), Expect = 1e-10
Identities = 91/396 (22%), Positives = 148/396 (37%), Gaps = 57/396 (14%)
Query: 893 FSDVRPNQQEYKISSFEQRLMNEIE-FRLERTPVDESDDEIQHDEIPTGKCIA------- 944
F D + + K F Q+ + +E F V E + + ++ G C+A
Sbjct: 3865 FKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVGKCG-CMATHLLKEP 3923
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F K++ G VT + G V W K G+++ + + KM +G L
Sbjct: 3924 PTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMK-GQEVIREDGKIKMSFS-NGVAVL 3981
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I G YT +A N G + G L+V KE
Sbjct: 3982 IIPDVQISFGGKYTCLAENEAGSQTSVGELIV--------------------------KE 4015
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P + R +Q G L+ V+G P + W +G+P++ +++ +
Sbjct: 4016 PAKI-IERAELIQVTA------GDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFK 4068
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V L D+G Y +N+ G +S +V+ +++ AP + L+N
Sbjct: 4069 NN-VAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDI--APFFTKPLRNVDSV 4125
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKSDAGW 1243
RL+C++ G P W KD + I + R RI+ G A L I +DAG
Sbjct: 4126 VNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAF---VEGTASLEIIRVDMNDAGN 4182
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
+T A N G + L + Q PP +P
Sbjct: 4183 FTCRATNSVGSKDSSGALIV------QEPPSFVTKP 4212
Score = 66.6 bits (161), Expect = 1e-10
Identities = 86/381 (22%), Positives = 144/381 (37%), Gaps = 77/381 (20%)
Query: 697 SNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQR 756
S A A+ T K++ A SS K + T P+ P F + TP T +
Sbjct: 833 SIAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYK- 891
Query: 757 TVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIP 816
S V+ K G+SI T T F + G + +
Sbjct: 892 ---------SEAGVEVKKEVGVSI---------TGTTVREERFEVLHGREAK-------- 925
Query: 817 VSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPR------------------SAPSMP-- 856
V+ T+R+ PV +P PPT GL +P++
Sbjct: 926 VTETARVPAPV--------EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 977
Query: 857 ----------------SQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT--FSDVRP 898
G+A+ + + +D+ R T +AV + G T + V+
Sbjct: 978 REDYQIESSIDFQITFQSGIARLMIR--EAFAEDSGRFTCSAV-NEAGTVSTSCYLAVQV 1034
Query: 899 NQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVT 957
+++ E + ++ ++ E + +E V +D + ++ G+ AP F + ++
Sbjct: 1035 SEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV 1094
Query: 958 EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
EG V F C++ G P P VYW K G ++ + + G C L I T +DD G Y
Sbjct: 1095 EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEY 1154
Query: 1018 TIMAANPQGRISCSGHLMVQS 1038
TI+ N G S S L+ ++
Sbjct: 1155 TIVVRNKHGETSASASLLEEA 1175
Score = 66.2 bits (160), Expect = 2e-10
Identities = 69/312 (22%), Positives = 112/312 (35%), Gaps = 37/312 (11%)
Query: 242 ASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVR 301
A AAG SS +SL +EP P F +K E +G V L+C + G PP V
Sbjct: 7380 AHNAAGS----ASSSTSLKVKEP----PIFRKKPHPIETLKGADVHLECELQGTPPFHVS 7431
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
WY + +EL + I+ L S+ I D G Y C A+N G+D+ I ++
Sbjct: 7432 WYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAP 7491
Query: 362 SSSDSE-GDPNKEEMNRIQKPNEVSSPPTTSAV------------------IPPAVPQAQ 402
+ D + +Q + S V + Q
Sbjct: 7492 PRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQ 7551
Query: 403 HLVAQPRVATIQQCQ--SPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
+P A CQ + + ++ + +++ + G EC V G
Sbjct: 7552 FSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAG 7611
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P +W+++G + ++I + ++ L I V DSG ++ N
Sbjct: 7612 TPELSTKWFKDGKELTSDNKYKI--------SFFNKVSGLKIINVAPSDSGVYSFEVQNP 7663
Query: 521 YGTVSSIAQLHV 532
G S A L V
Sbjct: 7664 VGKDSCTASLQV 7675
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 243 SEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
+E G + P + S+ + G+ P ++++ G QL C +VG P P ++W
Sbjct: 30507 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 30566
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
Y GKEL S + G H+LT+ +ED G Y+C A+N G TS+++ ++ +
Sbjct: 30567 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ-AT 30625
Query: 363 SSDSEGDPNKEE 374
G P KE+
Sbjct: 30626 PQFHPGYPLKEK 30637
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/113 (32%), Positives = 57/113 (50%), Gaps = 1/113 (0%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-NLHSLT 327
P F + L + E EG V + V GIPPP ++W +G+ L P+I I+ G + ++L
Sbjct: 31795 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 31854
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
I + EDTG Y A+N G+ S A + +E + E +E +QK
Sbjct: 31855 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEHERHVQK 31907
Score = 65.9 bits (159), Expect = 3e-10
Identities = 84/337 (24%), Positives = 126/337 (37%), Gaps = 49/337 (14%)
Query: 228 LEQQEAKRREAEQAASEA---AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGT 284
LE + +R+A Q + E AG D G+ S+L +PP F +L E G
Sbjct: 6043 LEILNSTKRDAGQYSCEIENEAGRDVC-GALVSTL-------EPPYFVTELEPLEAAVGD 6094
Query: 285 RVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
V L C V G P V WY +L +P+ N+ +L + D+G Y+C A
Sbjct: 6095 SVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAE 6154
Query: 345 NIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHL 404
N GT S+ I+ S K+ + P ++ SA I + L
Sbjct: 6155 NSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVL 6214
Query: 405 VAQ---------PRVATIQQCQ-----------SPTNYLQGLDGKPIIAA------PVFT 438
+ VAT++ Q S +N L + A P F
Sbjct: 6215 LRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFD 6274
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI--LQKKPRSMAEPEE 496
++ G+ FEC V GA ++ W ++ I ++ I + P
Sbjct: 6275 IKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPH------- 6327
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I +V DSG +TC A+N G AQL V+
Sbjct: 6328 ---LRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVK 6361
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 1052 HRGRSRVQE--RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
H ++V E R P++ P + ++ EG L+C +SG P P +TW
Sbjct: 920 HGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRE 979
Query: 1110 GQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEV 1168
+ ++ ++G+ L+I D+G + C A N+ G S S L+V V++E
Sbjct: 980 DYQIESSIDFQITF-QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF 1038
Query: 1169 KK----------------------------------------APVILEKLQNCGVPEGHP 1188
+K AP + K + EG
Sbjct: 1039 EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGS 1098
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCT---RERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
V C+V G P P YWKK +P T R ++S ++ TG L+I DAG YT
Sbjct: 1099 VVFGCQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQ-TGECKLVISMTFADDAGEYT 1155
Query: 1246 LSAKNEAGIVSCTARL 1261
+ +N+ G S +A L
Sbjct: 1156 IVVRNKHGETSASASL 1171
Score = 65.5 bits (158), Expect = 3e-10
Identities = 63/268 (23%), Positives = 95/268 (35%), Gaps = 68/268 (25%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP FT L ++ G V+ + P P V WY G++++ N
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIK--------PGDNDK 31737
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
T FE D G Y +++ D + DS K ++ P
Sbjct: 31738 KYT----FESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDS----CKAKLTVTLHP--- 31786
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
PPT S + P+F ++L N
Sbjct: 31787 --PPTDSTL----------------------------------------RPMFKRLLANA 31804
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
EGQ V FE RV G P P ++W ++G + P+ I+ E + L I +
Sbjct: 31805 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIH-------EGLDYYALHIRD 31857
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
ED+G + TA+N G+ S A L V
Sbjct: 31858 TLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 64.7 bits (156), Expect = 6e-10
Identities = 52/211 (24%), Positives = 86/211 (40%), Gaps = 10/211 (4%)
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
+V W+KDGK++ K N H + DGT L I + T D G Y + G +
Sbjct: 32748 EVTWYKDGKKL-KENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQF 32806
Query: 1035 MVQSL-PIRSRLTSAGQSHRGRSRVQE----RDKEPL--QERFFRPHFLQAPGDMVAHEG 1087
M Q+ I +++ ++ + + E R EP + +P + D
Sbjct: 32807 MGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSD 32866
Query: 1088 RLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCI 1147
+ + K +G P P W +G+ + +K L + G L I D+G Y C
Sbjct: 32867 SVAKFAVKATGEPRPTAIWTKDGKAITQGGKYK-LSEDKGGFFLEIHKTDTSDSGLYTCT 32925
Query: 1148 ATNKTGQNSFSLELSVVA-KEVKKAPVILEK 1177
N G S S +L++ A K+ + V +K
Sbjct: 32926 VKNSAGSVSSSCKLTIKAIKDTEAQKVSTQK 32956
Score = 63.5 bits (153), Expect = 1e-09
Identities = 62/255 (24%), Positives = 104/255 (40%), Gaps = 44/255 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP +R++ V +GS F ++VG P P+ W+K+G +I +R++ D C
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI-ERSDRIYWYWPEDNVCE 2135
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I T++D + + A N G S L+VQ+ + +
Sbjct: 2136 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLIT-------------------- 2175
Query: 1064 EPLQERFFRPHFLQAPGDMVAHE-GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F Q D+VA E + +C+ S P ++ W +G V ++M
Sbjct: 2176 -----------FTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDGMEVHEGDKYRM- 2222
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQN 1180
+ VH L I + DA Y C+ + AK + + V+ +++LQ+
Sbjct: 2223 HSDRKVHFLSILTIDTSDAEDYSCVLVEDE-------NVKTTAKLIVEGAVVEFVKELQD 2275
Query: 1181 CGVPEGHPVRLECRV 1195
VPE + LEC V
Sbjct: 2276 IEVPESYSGELECIV 2290
Score = 63.5 bits (153), Expect = 1e-09
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 51/252 (20%)
Query: 282 EGTRVQLDCIVVGIPPP-QVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
EG V+ C + QV WY ++LENS I + L + + + D G Y
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYR 31640
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C N YG DS+ AE++++GV + + M +I++
Sbjct: 31641 CKVVNDYGEDSSYAELFVKGV--REVYDYYCRRTMKKIKR-------------------- 31678
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
R T++ + P P FT L N +A G+ V F +
Sbjct: 31679 --------RTDTMRLLERP---------------PEFTLPLYNKTAYVGENVRFGVTITV 31715
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P P V WY+ G I+ + K + + + L I V +D +T A NK
Sbjct: 31716 HPEPHVTWYKSGQKIKPGDN-----DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 31770
Query: 521 YGTVSSIAQLHV 532
YG S A+L V
Sbjct: 31771 YGEDSCKAKLTV 31782
Score = 63.2 bits (152), Expect = 2e-09
Identities = 73/299 (24%), Positives = 119/299 (39%), Gaps = 52/299 (17%)
Query: 267 QPPRFTQKLR-SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
+PPRF +KL SR V + + +C + G P +V WY + E++ S + ++
Sbjct: 7303 EPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAV 7362
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIY-------------IEGVSSSD------S 366
L + ED+G Y+C A N G+ S+S + IE + +D
Sbjct: 7363 LEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECEL 7422
Query: 367 EGDP--------NKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQS 418
+G P +K E+ +K +S TS I A I + Q
Sbjct: 7423 QGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHI-----------LNVDAADIGEYQC 7471
Query: 419 PTNYLQGLD----GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYRE-GT 473
G D + A P F K L ++S G+ V + ++GA V W+++ G
Sbjct: 7472 KATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGE 7531
Query: 474 LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
++ +S + I + E I TL + V ++G +TC N G A L V
Sbjct: 7532 IVRESDNIWI--------SYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSV 7582
Score = 62.8 bits (151), Expect = 2e-09
Identities = 63/284 (22%), Positives = 110/284 (38%), Gaps = 37/284 (13%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP F +K+ + + V G PP + W + + L+ +++I ++
Sbjct: 5044 LKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVA 5103
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTD--------STSAEIYIEGVSSSDSEGDPNKEEMN 376
+L I +GRY+C A N G + A+I + S +E DP E
Sbjct: 5104 TLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECV 5163
Query: 377 RIQKPN-EVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQ---------------CQS 418
P +V ++P ++ VA R+ ++ + S
Sbjct: 5164 VAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSS 5223
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
YL+ LD P FTK L + G + EC+V G+ +W+++G I S
Sbjct: 5224 CDAYLRVLDQN---IPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTS 5280
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+R++ E +L + + ED+ +TC SN G
Sbjct: 5281 AKYRLVCH--------ERSVSLEVNNLELEDTANYTCKVSNVAG 5316
Score = 62.4 bits (150), Expect = 3e-09
Identities = 63/304 (20%), Positives = 121/304 (39%), Gaps = 31/304 (10%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP F K S++V G+ V L G P +RW+ KEL + +I + SL
Sbjct: 4204 EPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSL 4263
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK--EEMNRIQKPNEV 384
+ D+G Y+C SN+ G SA ++++ ++ + +P++ ++ + Q +V
Sbjct: 4264 ELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKV 4323
Query: 385 SSPP-------TTSAVIPPAVPQAQHLVAQPRVATI----------QQCQSPTNYLQGLD 427
+ P I + V V + C++
Sbjct: 4324 TGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHC 4383
Query: 428 GKPIIA--APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQ 485
+I +P FTK + + + V+ V G P ++ W+++ T++ ++
Sbjct: 4384 SSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFI 4443
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLH 545
+ + + +L I + A D+G + C +N+ G SSI V E S +
Sbjct: 4444 Q--------DHLVSLQILKFVAADAGEYQCRVTNEVG--SSICSARVTLREPPSFIKKIE 4493
Query: 546 SANS 549
S +S
Sbjct: 4494 STSS 4497
Score = 61.6 bits (148), Expect = 5e-09
Identities = 65/293 (22%), Positives = 114/293 (38%), Gaps = 39/293 (13%)
Query: 267 QPPRFTQKLR-SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
+P F +KL S+ + +G QL C V G PP ++ W+ +E++ S + +
Sbjct: 4297 EPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAV 4356
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK--EEMNRIQKPNE 383
L + + ED+G Y C A N G+D S+ + ++ E P + +E + +
Sbjct: 4357 LRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEV 4416
Query: 384 VSSPP----------------TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLD 427
+PP I + Q L A QC+ TN +
Sbjct: 4417 AGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCR-VTNEV---- 4471
Query: 428 GKPIIAA-------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
G I +A P F K +++ S+ G F+ +KG+ V W ++ I + +
Sbjct: 4472 GSSICSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDN 4531
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
R M + +L ++ + + G + C A N G A L V+
Sbjct: 4532 IR--------MTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVK 4576
Score = 60.8 bits (146), Expect = 8e-09
Identities = 81/357 (22%), Positives = 127/357 (35%), Gaps = 67/357 (18%)
Query: 266 GQP--PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV---QA 320
G+P P F K +++ EG V C V G P P V W G L + Q
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQT 1136
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG----VSSSDSEGDPNKEEMN 376
G L I+ F +D G Y+ N +G S SA + E + S E +
Sbjct: 1137 GEC-KLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTA 1195
Query: 377 RIQKPNEVSSPP-----------------------TTSAVIPPAVPQAQHLVAQPRVATI 413
+Q+P + P + V+ V + ++ I
Sbjct: 1196 FVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLI 1255
Query: 414 QQCQ-----SPTNYLQGLDGKPIIAAPV---------FTKMLQNLSASEGQLVVFECRVK 459
++ + + L DG+ +A + F ++N EG V F C++
Sbjct: 1256 KEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMS 1315
Query: 460 GAPSPKVEWYREGTLIEDSPDFRI--LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
G P PK+ WY++G I+ +++ LQ S+ P V ED G +T A
Sbjct: 1316 GYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIP---------VVLPEDEGIYTAFA 1366
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
SN G +L+V L + T + +EP P SV + P
Sbjct: 1367 SNIKGNAICSGKLYVEPAAPL---------GAPTYIPTLEPVSRIRSLSPRSVSRSP 1414
Score = 60.8 bits (146), Expect = 8e-09
Identities = 85/347 (24%), Positives = 134/347 (38%), Gaps = 61/347 (17%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
RV EG F C++ G P PKV W+ +G+ I K + R DG L I S D
Sbjct: 1851 RVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK---RFRVRYDGIHYLDIVDCKSYDT 1907
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G + A NP+G I L +Q Q RS V R EP RP
Sbjct: 1908 GEVKVTAENPEGVIEHKVKLEIQ------------QREDFRS-VLRRAPEP------RPE 1948
Query: 1075 F-LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV----LPDASHKMLVR----- 1124
F + PG + + + ++D V E+ L + + +P+ S ++ +
Sbjct: 1949 FHVHEPGKL---QFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRT 2005
Query: 1125 ETGVHSLLID---PLTQRDAGTYKCIATNKTGQNSFSLELS-----VVAKEVK------- 1169
E G + + ++D + + K ++ EL+ +A+E K
Sbjct: 2006 EEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFK 2065
Query: 1170 ----------KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+AP I E++Q+ V +G RV+G P P W K+ I +RI
Sbjct: 2066 PDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRI 2124
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ L+I+ D+ + A N AG S A L + A+
Sbjct: 2125 YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2171
Score = 60.8 bits (146), Expect = 8e-09
Identities = 82/331 (24%), Positives = 126/331 (38%), Gaps = 67/331 (20%)
Query: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
D+S E+ E PT F + L+ VTE F+C++ V W+++G++I
Sbjct: 12810 DKSVAELLIIEAPTE------FVEHLEDQTVTEFDDAVFSCQL-SREKANVKWYRNGREI 12862
Query: 986 SKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
E K + E DG+ L I+ DD+ Y + + R L V+ +P+
Sbjct: 12863 K---EGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSR----ARLFVEEIPVE-- 12913
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERFFRP--HFLQAPGDMVAHEGRLCRLDCKVSGLPPP 1102
RP L+APG V L +
Sbjct: 12914 -------------------------IIRPPQDILEAPGADVVFLAELNK--------DKV 12940
Query: 1103 ELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELS 1162
E+ WL N V+ H+M+ E +H L I + RD G Y+ IA +K +
Sbjct: 12941 EVQWLRNNMVVVQGDKHQMM-SEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKL----- 12994
Query: 1163 VVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
E+ AP I Q+ V G P+ + P W K+NE P + + I
Sbjct: 12995 ----ELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENE--PLSTKTIDTT 13048
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ T + L AKK D G Y + +N+ G
Sbjct: 13049 AEQTSFRIL---EAKKGDKGRYKIVLQNKHG 13076
Score = 60.5 bits (145), Expect = 1e-08
Identities = 72/290 (24%), Positives = 116/290 (40%), Gaps = 34/290 (11%)
Query: 267 QPPRFTQKLRSREVP-EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
+PP+F +KL + +V +G +QL+C + G P +V W+ EL S ++ ++
Sbjct: 6362 EPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVAL 6421
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDP-NKEEMNRIQKPNEV 384
LTI EA ED+G Y C A N G S S + ++ + P + + + E+
Sbjct: 6422 LTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEI 6481
Query: 385 SSPPTTSAVIPPAVPQ----------AQHLVAQPRVATIQ-------QCQSPTNYLQGLD 427
S P V Q ++H + ++ C++ TN + G D
Sbjct: 6482 SGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKA-TNEV-GSD 6539
Query: 428 ----GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYRE-GTLIEDSPDFR 482
P F K L + S G V V+G V W ++ G +I +S + R
Sbjct: 6540 TCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTR 6599
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
I + + I TL + A +SG + C N G A L V
Sbjct: 6600 I--------SFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTV 6641
Score = 60.5 bits (145), Expect = 1e-08
Identities = 145/725 (20%), Positives = 229/725 (31%), Gaps = 133/725 (18%)
Query: 365 DSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
D+E E R + P+ VSS + S A + A Q S Y +
Sbjct: 32303 DTERRSPTPERTRPRSPSPVSSERSLSRFERSARFDIFSRYESMKAALKTQKTSERKY-E 32361
Query: 425 GLDGKPIIA--APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
L +P AP T +++ GQ F V+ P+ +V+WY G +++S
Sbjct: 32362 VLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH 32421
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ TL I + +DSG + +N G S A L V G +
Sbjct: 32422 Y--------TNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGD------ 32467
Query: 543 SLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNL 602
T A+ P S P + + + SSS ++
Sbjct: 32468 -------YTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTE 32520
Query: 603 PEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQ 662
+ S S + + + S +E+ + KT + +L KP+
Sbjct: 32521 TRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR-------ILTKPR----- 32568
Query: 663 LQQLHNQVLLEQHQLQNPPPSSPKEFPFSM-----TVLNSNAPPAVTTSSKQVKAPSSQT 717
+ + E + + + P VL+++A VTT+ + S
Sbjct: 32569 -----SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 32623
Query: 718 FSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGG 777
+ Y N+ A FTL TIQ+ E + S P V++ P
Sbjct: 32624 QASDEGNYSVVVENSEGKQEAE-----FTL-----TIQKARVTEKAVTSPPRVKSPEPRV 32673
Query: 778 LSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSL 837
S + P P P P+ VSP PT
Sbjct: 32674 KSPEAVKSPKRVKSPEPS------------HPKAVSPTETKPT----------------- 32704
Query: 838 PAIPPTNAMGLPRSAPSMPSQGL---AKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT-- 892
P LP SAP +Q L A K V + ++ K GKK+
Sbjct: 32705 ---PTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKEN 32761
Query: 893 ----FSDVRPNQQEYKISSFEQRLMNEI--------------------EFRLERTPVDES 928
F E KI++ + E F+ V +
Sbjct: 32762 GHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 32821
Query: 929 DDEIQHDEIPTGKCIA--------------PIFDKRLKHFRVTEGSPVTFTCKIVGIPVP 974
+ + D+ T + P+ L+ V+ S F K G P P
Sbjct: 32822 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 32881
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
W KDGK I++ ++ E G L I T + D G YT N G +S S L
Sbjct: 32882 TAIWTKDGKAITQGGKY--KLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 32939
Query: 1035 MVQSL 1039
++++
Sbjct: 32940 TIKAI 32944
Score = 60.1 bits (144), Expect = 1e-08
Identities = 56/275 (20%), Positives = 102/275 (37%), Gaps = 28/275 (10%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP FT++L++ G L+C V G P V W+ E ++ + + N+ +L
Sbjct: 5799 PPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQ 5858
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-------------- 373
+ D G Y+C A+N+ G+D A + ++ S E +P +
Sbjct: 5859 LNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRG 5918
Query: 374 ----EMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ-GLDG 428
++N + E+ + V + + + C N Q
Sbjct: 5919 TPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTT 5978
Query: 429 KPIIAAP-VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
+ + P F K L + S G+ ++ E G V W ++G F I +
Sbjct: 5979 RLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDG--------FNITTSE 6030
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
++ E+ C L I D+G ++C N+ G
Sbjct: 6031 KCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAG 6065
Score = 59.7 bits (143), Expect = 2e-08
Identities = 141/685 (20%), Positives = 238/685 (34%), Gaps = 114/685 (16%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P +FT+++++ V E +C V V WY EL S + G H +
Sbjct: 8832 EPIQFTKRIQNIVVSEHQSATFEC-EVSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYM 8890
Query: 327 TIAEAFEEDTGRYSCFAS-NIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMN--------R 377
TI +D G YS A G ++AE+Y+ P+ + R
Sbjct: 8891 TIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTMPIR 8950
Query: 378 IQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVF 437
P E+ PP + IP +P + P+ + T D K ++A P
Sbjct: 8951 AVPPEEI--PPVVAPPIPLLLPTPEEKKPPPKRIEV------TKKAVKKDAKKVVAKP-- 9000
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLI-EDSPDFRILQKKPRSMAEPEE 496
++ E VK P P TLI +P+ + K AE +
Sbjct: 9001 -----------KEMTPREEIVKKPPPPT-------TLIPAKAPEIIDVSSK----AEEVK 9038
Query: 497 ICTLV-IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAA 555
I T+ EV E + K V ++ + E+ +
Sbjct: 9039 IMTITRKKEVQKEKEAVY-----EKKQAVHKEKRVFIESFEEPYDE-------------- 9079
Query: 556 IEPQPSPPHSEPPSVEQPPKP----KLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKG--- 608
+E +P E P E+P + K+E H E G + D+G
Sbjct: 9080 LEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEE 9139
Query: 609 -SEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLH 667
EA E V+ ++ + ER K PE +P PP V+ KP ++ ++++
Sbjct: 9140 WEEAYQEREVIQVQKEVYEESHER--KVPAKVPEKKAP--PPPKVIKKPVIE--KIEKTS 9193
Query: 668 NQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFF 727
++ E+ Q+ P S K P S P +V A ++ ++ K FF
Sbjct: 9194 RRMEEEKVQVTKVPEVSKKIVPQK----PSRTPVQEEVIEVKVPAVHTKKMVISEEKMFF 9249
Query: 728 PSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPP 787
S +V + P+ + V++E + H ++ + + P P
Sbjct: 9250 ASHTEEEVSV-----------TVPEVQKEIVTEEKI---HVAISKRVEPPPKVPELPEKP 9295
Query: 788 GPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMG 847
P E P P IP + V +P P + PV + P +P
Sbjct: 9296 APEEVAPVP----IPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKP 9351
Query: 848 LPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISS 907
+P +P +AKK P + E + V+ + +KIT R +
Sbjct: 9352 VPEEKIPVP---VAKKKEAPPA-----KVPEVQKGVVTE--EKITIVTQREESPPPAVPE 9401
Query: 908 FEQRLMNEIEFRLERTPVDESDDEI 932
++ + E ER PV ++E+
Sbjct: 9402 IPKKKVPE-----ERKPVPRKEEEV 9421
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT ++ P + AP + +Q+ + +G F RV G P P+ EWY+ G IE S
Sbjct: 2062 PTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERS 2121
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
RI P + +C LVI +V AEDS A N G SS A L V+ + +
Sbjct: 2122 D--RIYWYWPE-----DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLI 2174
Query: 539 SNNGSLHS--ANSTTNLAAIEPQPSPP 563
+ L A +A E + S P
Sbjct: 2175 TFTQELQDVVAKEKDTMATFECETSEP 2201
Score = 59.3 bits (142), Expect = 2e-08
Identities = 68/301 (22%), Positives = 110/301 (36%), Gaps = 49/301 (16%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP F +K+ G V L V G P V W + + I + + +
Sbjct: 3920 LKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVA 3979
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--------SDSEGDPNKEEMN 376
L I + G+Y+C A N G+ ++ E+ ++ + + GDP E
Sbjct: 3980 VLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYT 4039
Query: 377 ------------------------RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVAT 412
RI N V+ SA + + Q+
Sbjct: 4040 VAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDS---GQYTFEISNEVG 4096
Query: 413 IQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
C++ L AP FTK L+N+ + +C++ G+ +V W+++G
Sbjct: 4097 SSSCETTFTVLDR------DIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDG 4150
Query: 473 TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
I S +RI A E +L I V D+G FTC A+N G+ S L V
Sbjct: 4151 KEIAASDRYRI--------AFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIV 4202
Query: 533 R 533
+
Sbjct: 4203 Q 4203
Score = 58.9 bits (141), Expect = 3e-08
Identities = 71/307 (23%), Positives = 116/307 (37%), Gaps = 35/307 (11%)
Query: 249 DTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV-PEGTRVQLDCIVVGIPPPQVRWYCEGK 307
D +S ++L+ +EP P+F +K V G +C + G P +V WY +G
Sbjct: 4845 DVGTATSKATLFVKEP----PQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGN 4900
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIY---------- 357
E+ I L + I+ A E++G Y C A N GT S S E+
Sbjct: 4901 EITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRE 4960
Query: 358 ---IEGVSSSDSE------GDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQP 408
+E V SD E G P E+ ++ E+ S + +V P
Sbjct: 4961 LKPVEVVKYSDVELECEVTGTP-PFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDP 5019
Query: 409 RVATIQQC--QSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKV 466
QC + + P F K ++N + F+ V G+P +
Sbjct: 5020 SDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISI 5079
Query: 467 EWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSS 526
W ++ ++++ + I + + + TL I V SG +TC A N+ G
Sbjct: 5080 TWLKDDQILDEDDNVYI--------SFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERC 5131
Query: 527 IAQLHVR 533
A L V+
Sbjct: 5132 YAFLLVQ 5138
Score = 58.9 bits (141), Expect = 3e-08
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 16/147 (10%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG----VPE 1185
S L++ L + ++ A N+ G++ SL L+VV ++ + P I +L G V
Sbjct: 15353 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 15412
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETI--------PCTRERISMHQDTTGYACLLIQPAK 1237
G PV + V G+P P W K NET+ T+E +S + T L I A
Sbjct: 15413 GEPVHIPADVTGLPMPKIEWSK-NETVIEKPTDALQITKEEVSRSEAKTE---LSIPKAV 15468
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDIY 1264
+ D G YT++A N G V +++Y
Sbjct: 15469 REDKGTYTVTASNRLGSVFRNVHVEVY 15495
Score = 57.8 bits (138), Expect = 7e-08
Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F +RL+ V +GS V ++ GIP P V +++DG +I + ++ +EGD SL
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDF-QISQEGD-LYSL 161
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ---SLPIRSRLTSAGQSHRGRSRVQER 1061
I +D G Y++ A N GR + + L+VQ +P + T + SR Q R
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESR-QTR 220
Query: 1062 DKEPLQERF 1070
++ ++ F
Sbjct: 221 IEKKIEAHF 229
Score = 56.6 bits (135), Expect = 2e-07
Identities = 52/196 (26%), Positives = 80/196 (40%), Gaps = 19/196 (9%)
Query: 849 PRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSF 908
PRS P QG + + +P D R K T S + N E+++ F
Sbjct: 15318 PRSNGGSPIQGYIIEKRRHDKP---DFERVNKRLCP-------TTSFLVENLDEHQMYEF 15367
Query: 909 EQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKI 968
+ +NEI E P + IQ DE+P I R +V G PV +
Sbjct: 15368 RVKAVNEIG---ESEPSLPLNVVIQDDEVPP--TIKLRLSVRGDTIKVKAGEPVHIPADV 15422
Query: 969 VGIPVPKVYWFKDGKQISKRNEHCKMRRE----GDGTCSLHIESTTSDDDGNYTIMAANP 1024
G+P+PK+ W K+ I K + ++ +E + L I +D G YT+ A+N
Sbjct: 15423 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNR 15482
Query: 1025 QGRISCSGHLMVQSLP 1040
G + + H+ V P
Sbjct: 15483 LGSVFRNVHVEVYDRP 15498
Score = 56.6 bits (135), Expect = 2e-07
Identities = 105/539 (19%), Positives = 201/539 (37%), Gaps = 76/539 (14%)
Query: 74 ESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQ 133
+ + A+ P K+ E + + SP+ +K SP P SPT +K +P
Sbjct: 32651 QKARVTEKAVTSPPRVKSPEPRVK---SPEAVK-SPKRVKSPEPSHPKAVSPTETKPTPT 32706
Query: 134 EAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKS-KLESQNKVM 192
E + Q+ + K+ A+ +E++ L S +R + +K K +N
Sbjct: 32707 E--KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHF 32764
Query: 193 QENSSS-------FSDLSERRERSSVPIPIPADTRDNEVN--------HALEQQEAKRRE 237
Q + S+ ++L+E + V I + ++ N ++ ++ +K E
Sbjct: 32765 QFHYSADGTYELKINNLTESDQGEYV-CEISGEGGTSKTNLQFMGQAFKSIHEKVSKISE 32823
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPP 297
+++ + T + P + EP+ P L+ V + + G P
Sbjct: 32824 TKKSDQKTTESTVTRKTEPKA---PEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPR 32880
Query: 298 PQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIY 357
P W +GK + + + L I + D+G Y+C N G+ S+S ++
Sbjct: 32881 PTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLT 32940
Query: 358 IEGVSSSD---------SEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQP 408
I+ + ++ SE P K+ + + E+S S I + ++Q +A
Sbjct: 32941 IKAIKDTEAQKVSTQKTSEITPQKKAVVQ----EEISQKALRSEEIKMSEAKSQEKLALK 32996
Query: 409 RVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ----------------NLSASEGQLV 452
A+ + I TK Q +S +EGQ +
Sbjct: 32997 EEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 33056
Query: 453 VFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGC 512
V + + GA V+W G + +S ++R ++ ++ TL I + D G
Sbjct: 33057 VLKANIAGATD--VKWVLNGVELTNSEEYRY------GVSGSDQ--TLTIKQASHRDEGI 33106
Query: 513 FTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL---------AAIEPQPSP 562
TC + K G V Q + +++LS+ + S + N+ I +PSP
Sbjct: 33107 LTCISKTKEGIVK--CQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 33163
Score = 55.8 bits (133), Expect = 3e-07
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 48/323 (14%)
Query: 59 DLPDLSAFLSQ---EELDESVN-LARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFE 114
+L D AF+SQ + ++E N L I+ +P + E + K P + + ++S
Sbjct: 33129 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEP---SPEIEWFKNNLPISISSNVSISRS 33185
Query: 115 PNFCQDNPRSPTSSKESPQEAKRPQY---CSETQS-----------KKVFLNKAADFIEE 160
N R+ + S K + CS T S ++V L + D
Sbjct: 33186 RNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGD---- 33241
Query: 161 LSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTR 220
+SL S SS+ ++ A K S +SSS S ++E + S
Sbjct: 33242 -TSLQGSFSSQSVQMSASKQEAS-------FSSFSSSSASSMTEMKFASMSA-------- 33285
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
++ + E ++ T SS S + G PP+ +
Sbjct: 33286 -----QSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISI 33340
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD--IHIVQAGNLHSLTIAEAFEEDTGR 338
EG + + C G P P+V W C G+++ + HI +L +L I + ++D G
Sbjct: 33341 DEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGL 33400
Query: 339 YSCFASNIYGTDSTSAEIYIEGV 361
Y+ N +G+DS + I+I +
Sbjct: 33401 YTLSLGNEFGSDSATVNIHIRSI 33423
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 2/95 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENS--PDIHIVQAGNLH 324
Q P FTQ L+S V EG+ + + G P P+V W+ +G+ + S P + I +
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
LTI + ++GRYS A+N G +++AE+ ++
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98
Score = 55.5 bits (132), Expect = 3e-07
Identities = 34/94 (36%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
Query: 267 QPPRFTQKLR-SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS 325
+PP F +K+ S + G +L C + G P QV W+ KEL S + + +
Sbjct: 3735 EPPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAI 3794
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
L I + ED+G YSC A N G+DS S EI I+
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIK 3828
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/149 (28%), Positives = 69/149 (46%), Gaps = 10/149 (6%)
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
HK ++ET ++D + ++ N+ G++ + VV KE + PV+ KL
Sbjct: 18151 HKGSIKET---HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKL 18207
Query: 1179 QNC-GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE---RISMHQDTTGYACLLIQ 1234
V G +RLE V G P P W KD + TR +I D++ ++ +
Sbjct: 18208 SGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS---LT 18264
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
AK+SD G Y ++A N AG A +++
Sbjct: 18265 KAKRSDGGKYVVTATNTAGSFVAYATVNV 18293
Score = 55.1 bits (131), Expect = 4e-07
Identities = 64/280 (22%), Positives = 107/280 (38%), Gaps = 33/280 (11%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T+ +++ EVPE +C V P + W G E+E S IV G LH L I
Sbjct: 2885 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNT 2943
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
ED+ Y+ + G D SA + + + + D N EE + I V+ +
Sbjct: 2944 STEDSAEYTF----VCGNDQVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISY 2999
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-------LDGKPIIAAPV-------- 436
+ V Q R + + N G + GK A +
Sbjct: 3000 KWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIE 3059
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
F K ++++ E + +FEC V P V+W ++ ++ + +I ++K
Sbjct: 3060 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEK--------Y 3110
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ L+I D+G +T A T A+L V G +
Sbjct: 3111 VHRLLIPSTRMSDAGKYTVVAGGNVST----AKLFVEGRD 3146
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACL 1231
P ++ L+N V EG V LEC + G P P W +++ I + + Q +G A L
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ--SGIARL 1000
Query: 1232 LIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+I+ A D+G +T SA NEAG VS + L +
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 1032
Score = 54.3 bits (129), Expect = 8e-07
Identities = 78/382 (20%), Positives = 141/382 (36%), Gaps = 55/382 (14%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS--PDFRILQKKPRSM 491
AP FT+ LQ++ EG FE + G P P+V W+R+G +I S P +I R+
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA- 63
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN------NGSLH 545
L I V +SG ++ A+N G +S A+L V+ N + ++
Sbjct: 64 -------KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVR 116
Query: 546 SANSTTNLAAIEPQPSPP---HSEPPSVEQ------PPKPKLEGVLVNHNEPRSSSRIGL 596
+ + P+P + + ++ + L +L+ P S +
Sbjct: 117 QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 597 RVHFNLPEDDKGSE----------------ASSEAGVVTTRQTRPD-SFQERFNGQATKT 639
++ +E S A + +RQTR + + F+ ++ T
Sbjct: 177 NATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT 236
Query: 640 PE--------PSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFS 691
E P K PP + KPK S + + L + Q PS + P
Sbjct: 237 VEMVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQ----SPSPIRHSPSP 292
Query: 692 MTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTP 751
+ + + P V + S + +S S+ P + +T AT P P +
Sbjct: 293 VRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVAT-GPEVPPPWKQEGYV 351
Query: 752 QTIQRTVSKESLLVSHPSVQTK 773
+ +E+ L + ++T+
Sbjct: 352 ASSSEAEMRETTLTTSTQIRTE 373
Score = 53.1 bits (126), Expect = 2e-06
Identities = 58/284 (20%), Positives = 104/284 (36%), Gaps = 35/284 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F ++L + +V L+C V V W +G++L D I + +L I
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYKICFEDKIATLEI 3703
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE--------------- 373
A +D+G Y C ASN G+ S SA + + S + DP+
Sbjct: 3704 PLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLKG 3763
Query: 374 ----EMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK 429
++ + E+S T + + + C++ +
Sbjct: 3764 SPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823
Query: 430 PIIAA--PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
I+ P F K L+ G + +C V G ++ W+++ I S +R+ +K
Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQK 3883
Query: 488 PRSMAEPEEICTLVIAEVF---AEDSGCFTCTASNKYGTVSSIA 528
+LV E+F + D G + C +N+ G +A
Sbjct: 3884 -----------SLVCLEIFSFNSADVGEYECVVANEVGKCGCMA 3916
Score = 53.1 bits (126), Expect = 2e-06
Identities = 68/307 (22%), Positives = 117/307 (38%), Gaps = 39/307 (12%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H L ++ K +A + A T ++L+ +EP P FT+ L + V EG
Sbjct: 12250 HTLTLRDVKLEDAGEVQLTAKDFKTH-----ANLFVKEP---PVEFTKPLEDQTVEEGAT 12301
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+C V +V+W+ G E+ S IV G + L I + ED Y+C A +
Sbjct: 12302 AVLEC-EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 12360
Query: 346 I--------------YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
+ T ++ + ++ + E ++ + E+
Sbjct: 12361 FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYD 12420
Query: 392 AVIPPAVPQAQHLVAQPRVATIQ---QCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+ AV + LV + + C+ T G+ + VFTK L N+ SE
Sbjct: 12421 IISKGAV---RILVINKCLLDDEAEYSCEVRTARTSGM-LTVLEEEAVFTKNLANIEVSE 12476
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C V P +V WY+ I ++ + IL + + + LVI E
Sbjct: 12477 TDTIKLVCEV-SKPGAEVIWYKGDEEIIETGRYEILTEGRKRI--------LVIQNAHLE 12527
Query: 509 DSGCFTC 515
D+G + C
Sbjct: 12528 DAGNYNC 12534
Score = 53.1 bits (126), Expect = 2e-06
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 4/128 (3%)
Query: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV---PEGTR 285
E E +R E A AA + P S + ++ + +PPR ++ R+V G
Sbjct: 25748 ELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV-EPPRVMMDVKFRDVIVVKAGEV 25806
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
++++ + G P P + W +G E+E I+ N LT+ + DTG+Y N
Sbjct: 25807 LKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKN 25866
Query: 346 IYGTDSTS 353
+ GT S +
Sbjct: 25867 VAGTRSVA 25874
Score = 52.8 bits (125), Expect = 2e-06
Identities = 67/291 (23%), Positives = 102/291 (35%), Gaps = 33/291 (11%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P +K V G L+C V G P V WY +GK L +S + SL
Sbjct: 5702 EPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSL 5761
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I +D G Y+ N G S +A + + + S K + +
Sbjct: 5762 RILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILEC 5821
Query: 387 PPTTSAVIPPA-VPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI-----IAA------ 434
S+ I A + +V+ + T T L LD + +AA
Sbjct: 5822 KVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSD 5881
Query: 435 -----------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
P F K + L G+ V F ++G P KV W+R R
Sbjct: 5882 ECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGA---------RE 5932
Query: 484 LQKKPR-SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L K R ++ + + L + + SG +TC SN G S +L V+
Sbjct: 5933 LVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVK 5983
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG 294
R + E E+ + + +P S + P+ Q P F ++LR+ V + L C V G
Sbjct: 30898 RVKCENLGGESEWSEISEPITPKS---DVPI-QAPHFKEELRNLNVRYQSNATLVCKVTG 30953
Query: 295 IPPPQVRWYCEGKELENSPDIHIVQ--AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P V+WY +GKE+ + +Q G H L IA ++D Y A+N G+ S
Sbjct: 30954 HPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSG 31013
Query: 353 SAEIYIE 359
+A + +E
Sbjct: 31014 TASLEVE 31020
Score = 52.4 bits (124), Expect = 3e-06
Identities = 71/307 (23%), Positives = 109/307 (35%), Gaps = 63/307 (20%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K LK+ VTE FT ++ V V W K+G + + NE + +G SL I++
Sbjct: 2711 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGV-VLESNEKYAISVKGT-IYSLRIKN 2768
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
D+ Y GR+ S L V+++ I
Sbjct: 2769 CAIVDESVYGFRL----GRLGASARLHVETVKI--------------------------- 2797
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ P D+ A E + VS P + W + P H+ LV E V
Sbjct: 2798 -------IKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHR-LVSERKV 2848
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
H L++ ++ DAG Y + GQ +L V + K ++N VPE
Sbjct: 2849 HKLMLQNISPSDAGEYTAV----VGQLECKAKLFVETLHITKT------MKNIEVPETKT 2898
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQPAKKSDAGWY 1244
EC V P + K E + +I +HQ L+I D+ Y
Sbjct: 2899 ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQ-------LIIMNTSTEDSAEY 2951
Query: 1245 TLSAKNE 1251
T N+
Sbjct: 2952 TFVCGND 2958
Score = 52.4 bits (124), Expect = 3e-06
Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 11/138 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRF---TQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
A G++ P P + ++ L +PP R + + G ++L I+ G+P P+V W
Sbjct: 17194 AAGESDPAHVPEPVLVKDRL-EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW 17252
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
E ++ I + G+ L I A ED G YS N G+ + S ++ +
Sbjct: 17253 KKEDRDAPTKARIDVTPVGS--KLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLV---- 17306
Query: 363 SSDSEGDPNKEEMNRIQK 380
D G P E++ I+K
Sbjct: 17307 -LDKPGPPRDLEVSEIRK 17323
Score = 52.4 bits (124), Expect = 3e-06
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVILEKLQN 1180
+V E+ V + ++ L+ ++ A N+ G++ L + V+AK++ P +
Sbjct: 24261 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 24320
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
+ G +++E VIG P P W KD E + T R+++ + T L I+ K D
Sbjct: 24321 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQT-TRVNVEETATS-TVLHIKEGNKDD 24378
Query: 1241 AGWYTLSAKNEAG 1253
G YT++A N AG
Sbjct: 24379 FGKYTVTATNSAG 24391
Score = 52.0 bits (123), Expect = 4e-06
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP K +++++ G+ C++ G P P ++WYR G ++Q + M+
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGK--------ELIQSRKYKMSS 30583
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
TL + ED G +TC A+N+ G V + ++L
Sbjct: 30584 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 30620
Score = 52.0 bits (123), Expect = 4e-06
Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRS 490
I AP F + L+NL+ C+V G P P V+WYR+G +I D +RI + K
Sbjct: 30925 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFK--- 30981
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L+IA V +D+ + A+N+ G+VS A L V
Sbjct: 30982 ----GGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 31019
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/135 (30%), Positives = 66/135 (48%), Gaps = 14/135 (10%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP-------EGHP 1188
LT+ T++ A N+ G+ + S E++VVA++ AP + K G+P E
Sbjct: 19945 LTEGKEYTFRVSAENENGEGTPS-EITVVARDDVVAPDLDLK----GLPDLCYLAKENSN 19999
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
RL+ + G P P WKK + + T R+S+ L++ +KSDAG YT++
Sbjct: 20000 FRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAVN-TTLIVYDCQKSDAGKYTITL 20057
Query: 1249 KNEAGIVSCTARLDI 1263
KN AG T + +
Sbjct: 20058 KNVAGTKEGTISIKV 20072
Score = 51.2 bits (121), Expect = 6e-06
Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 18/187 (9%)
Query: 215 IPAD--TRDNEVNHALEQQEAKRREAEQAAS------EAAGGDTTPGSSPSSLYYEEPLG 266
+P D R N H + Q+E E+ A + +P S PS
Sbjct: 19231 LPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAEN 19290
Query: 267 QPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PPR + + V GT V LD V G P P V W +G L+ + I + NL
Sbjct: 19291 VPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL 19350
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
+L + +D+G Y+ A N G+ S + ++ + D G P ++N++
Sbjct: 19351 CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV-----LDKPGPPASVKINKMYSDRA 19405
Query: 384 VSS--PP 388
+ S PP
Sbjct: 19406 MLSWEPP 19412
Score = 51.2 bits (121), Expect = 6e-06
Identities = 27/87 (31%), Positives = 41/87 (47%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T ++ VP G V+L + G PPP W+ G +L S + + + LTI E
Sbjct: 29742 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET 29801
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYI 358
DTG Y+ N+ GT S + ++ I
Sbjct: 29802 TIRDTGEYTLELKNVTGTTSETIKVII 29828
Score = 50.8 bits (120), Expect = 8e-06
Identities = 92/406 (22%), Positives = 152/406 (37%), Gaps = 92/406 (22%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
K + P + + LQ+++ EGQ C+ P+ K EW+R G RIL+ +
Sbjct: 8739 KLTVIEPAWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNG---------RILKPQG 8788
Query: 489 RSMAEPE-EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSA 547
R E E ++ L IA+V AED G +TC KY + + A+L + +
Sbjct: 8789 RHKTEVEHKVHKLTIADVRAEDQGQYTC----KYEDLETSAELRIEAE-------PIQFT 8837
Query: 548 NSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHF----NLP 603
N+ E Q + E S + +G + + R R H+ N+
Sbjct: 8838 KRIQNIVVSEHQSATFECE-VSFDDAIVTWYKGPTELTESQKYNFRNDGRCHYMTIHNVT 8896
Query: 604 EDDKG-----------SEASSEAGV-VTTRQTR--------PDSFQERFNGQATKTPEPS 643
DD+G EA S A + +TT++ + PDS + P P+
Sbjct: 8897 PDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPDS----------RVPIPT 8946
Query: 644 SPVK-----EPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSN 698
P++ E PPV+A P +LL + + PP PK + + +
Sbjct: 8947 MPIRAVPPEEIPPVVAPP-----------IPLLLPTPEEKKPP---PKRIEVTKKAVKKD 8992
Query: 699 A------PPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSST-P 751
A P +T + VK P P P+ V+ + V ++ T
Sbjct: 8993 AKKVVAKPKEMTPREEIVKKPPP-------PTTLIPAKAPEIIDVSSKAEEVKIMTITRK 9045
Query: 752 QTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPF 797
+ +Q+ KE++ +V + + EP EP PF
Sbjct: 9046 KEVQK--EKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPF 9089
Score = 50.8 bits (120), Expect = 8e-06
Identities = 110/506 (21%), Positives = 175/506 (34%), Gaps = 73/506 (14%)
Query: 555 AIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSE 614
A+ +P P ++ P V P KP LE + + + R PE + E +
Sbjct: 10763 AVPKKPEVPPAKVPEV--PKKPVLE--------EKPAVPVPERAESPPPEVYEEPEEIAP 10812
Query: 615 AGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPP----PVLAKPKLDSTQLQQLHNQV 670
+ + +P E + P P K P PV+ KP ++ ++ +
Sbjct: 10813 EEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKP--EAPPPKEPEPEK 10870
Query: 671 LLEQHQLQN----PPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYF 726
++E+ +L+ PPP+ PKE + A P K + L
Sbjct: 10871 VIEKPKLKPRPPPPPPAPPKE-DVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLK----- 10924
Query: 727 FPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLP 786
P + P P + + ++V ++ P V+ K +
Sbjct: 10925 VPGGEKKVRKLLPERKP----EPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVK------- 10973
Query: 787 PGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAM 846
P P PPP P+ V + V ++ + + + V PAIP
Sbjct: 10974 -KPAVPEPPP------------PKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIP----- 11015
Query: 847 GLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYK-- 904
LP AP + A+ T P PV + + +GKK + + K
Sbjct: 11016 -LP--APEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGP 11072
Query: 905 ISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTG---KCIAPIFDKRLKHFRVTE--- 958
I ++ + IE R S E DE P K + F K +K +TE
Sbjct: 11073 IKGVPKKTPSPIEAE-RRKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEF 11131
Query: 959 -GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLHIESTTSDDDGN 1016
GS F C +V W KDG I + +H R DG LHI D G
Sbjct: 11132 VGSSAIFEC-LVSPSTAITTWMKDGSNIRESPKH---RFIADGKDRKLHIIDVQLSDAGE 11187
Query: 1017 YTIMAANPQGRISCSGHLMVQSLPIR 1042
YT + + + L+V+ LP+R
Sbjct: 11188 YTCVLRLGNKEKTSTAKLVVEELPVR 11213
Score = 50.4 bits (119), Expect = 1e-05
Identities = 58/292 (19%), Positives = 105/292 (35%), Gaps = 54/292 (18%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP F + L ++ GT L C V G P ++ W+ + K++ +S + +L L
Sbjct: 3829 EPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCL 3888
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I D G Y C +N G A + KE ++K +++ +
Sbjct: 3889 EIFSFNSADVGEYECVVANEVGKCGCMATHLL-------------KEPPTFVKKVDDLIA 3935
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAP--------VFT 438
+ + AV ++ + + + +G ++ P +T
Sbjct: 3936 LGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYT 3995
Query: 439 KMLQNLSASE---GQLVV----------------------FECRVKGAPSPKVEWYREGT 473
+ +N + S+ G+L+V E V G P K +WY++G
Sbjct: 3996 CLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGR 4055
Query: 474 LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ S +RI K + L DSG +T SN+ G+ S
Sbjct: 4056 PLVASKKYRISFK--------NNVAQLKFYSAELHDSGQYTFEISNEVGSSS 4099
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 8/89 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
L+ G V + V G P P V W ++GTL++ + + MA +CTL +
Sbjct: 19305 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK--------MAMQRNLCTLELF 19356
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
V +DSG +T TA N G+ S+ +L V
Sbjct: 19357 SVNRKDSGDYTITAENSSGSKSATIKLKV 19385
Score = 50.1 bits (118), Expect = 1e-05
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVR 1190
+I LTQ + ++ +A N+ G++ SL + +VAK++ P + + V G ++
Sbjct: 23189 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 23248
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E + G P P W KD + T RI++ D+ L I+ K D G Y ++ N
Sbjct: 23249 IEVPISGRPKPTITWTKDGLPLKQT-TRINV-TDSLDLTTLSIKETHKDDGGQYGITVAN 23306
Query: 1251 EAG 1253
G
Sbjct: 23307 VVG 23309
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 14/144 (9%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV-----ILEKLQNCGVPEGHPVR 1190
LT+ + T++ +A N G+++ V+ KE P I +KL G ++
Sbjct: 21027 LTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--GDNIK 21084
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E V+G P P WKK ++ + T +R++ T L I +SD+G Y L+A+N
Sbjct: 21085 VEIPVLGRPKPTVTWKKGDQILKQT-QRVNFETTATS-TILNINECVRSDSGPYPLTARN 21142
Query: 1251 EAGIVSCTARLDIYAQWHHQIPPP 1274
G V D+ H IP P
Sbjct: 21143 IVGEVG-----DVITIQVHDIPGP 21161
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/295 (24%), Positives = 113/295 (38%), Gaps = 55/295 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDD 1013
+V EG V K+ V V W KDG+++ + H + ++ L IE T +D
Sbjct: 2366 KVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRVHIVIDKQSH---MLLIEDMTKED 2421
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
GNY+ P +S SG + V S+ + + L
Sbjct: 2422 AGNYSFTI--PALGLSTSGRVSVYSVDVITPLK--------------------------- 2452
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
D+ EG L+CKVS + W LN + + PD + +V+ T L+I
Sbjct: 2453 -------DVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT-KQRLVI 2504
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ D G YK I G+ + LSV +++K I+ L++ E V E
Sbjct: 2505 NRTHASDEGPYKLI----VGRVETNCNLSV--EKIK----IIRGLRDLTCTETQNVVFEV 2554
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+ V + KD E P ++ +I H L + K D G YT A
Sbjct: 2555 ELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYK---LTVLNMMKDDEGKYTFYA 2606
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 54/300 (18%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K +K+ V E +F C++ VP + W K+G +I + +E K+ +G L I +
Sbjct: 2886 KTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEI-EMSEKFKIVVQGK-LHQLIIMN 2942
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
T+++D YT + N Q S L V + I S L +E+D +
Sbjct: 2943 TSTEDSAEYTFVCGNDQ----VSATLTVTPIMITSMLKDI--------NAEEKDTITFEV 2990
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
V +EG WL NG + +M ++
Sbjct: 2991 -------------TVNYEG--------------ISYKWLKNGVEIKSTDKCQMRTKKL-T 3022
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
HSL I + DA Y +A G+ + + L V A+ ++ + +++ V E
Sbjct: 3023 HSLNIRNVHFGDAADYTFVA----GKATSTATLYVEARHIE----FRKHIKDIKVLEKKR 3074
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
EC V P W KD++ + T +RI + ++ + LLI + SDAG YT+ A
Sbjct: 3075 AMFECEV-SEPDITVQWMKDDQELQIT-DRIKIQKEKYVHR-LLIPSTRMSDAGKYTVVA 3131
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/229 (27%), Positives = 91/229 (39%), Gaps = 43/229 (18%)
Query: 844 NAMGLPRSAPSMPSQGLAKKNTKSPQPVND--DNIRETK----NAVIRDLGKKIT----- 892
N+ GL S+PS PS+ + P D D RET N +RD G KI
Sbjct: 27835 NSAGL--SSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE 27892
Query: 893 ------------FSDVRPNQQEYKISSFEQRLMNEIEFRL-ERTPVDESDDEIQHDEI-- 937
F+DV ++ +Y ++ + EFR+ R V Q I
Sbjct: 27893 KRQGNERWVRCNFTDV--SECQYTVTGLSPG--DRYEFRIIARNAVGTISPPSQSSGIIM 27948
Query: 938 PTGKCIAPIFDKRLKHFR---VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKM 994
+ + PI + ++F + G + + G PVP+V WFKDG +I KR M
Sbjct: 27949 TRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR-----M 28003
Query: 995 RREGD---GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
E G+ SL + T D G YT+ A N G + VQ P
Sbjct: 28004 NMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 28052
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 8/126 (6%)
Query: 1143 TYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
+++ A N G + +S ++ + E+ + + + + G +RL V G
Sbjct: 29414 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGR 29473
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
PPPV W K + ++ T Y+ L++ + DAG YT+ A+N++G S T
Sbjct: 29474 PPPVITWSKQGIDLASR----AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSAT 29529
Query: 1259 ARLDIY 1264
+ +Y
Sbjct: 29530 VLVKVY 29535
Score = 48.9 bits (115), Expect = 3e-05
Identities = 42/185 (22%), Positives = 74/185 (40%), Gaps = 13/185 (7%)
Query: 187 SQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRR---------- 236
+ KV +E+ S R E + + + + + E+ K +
Sbjct: 1986 THEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKEL 2045
Query: 237 -EAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
E E+ A G T P P + P + P+ ++++S+ V +G+ VVG
Sbjct: 2046 TEEEKKALAEEGKITIPTFKPDKIELS-PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGK 2104
Query: 296 PPPQVRWYCEGKELENSPDIH-IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P+ WY G ++E S I+ N+ L I + ED+ A NI G S+ A
Sbjct: 2105 PDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHA 2164
Query: 355 EIYIE 359
+ ++
Sbjct: 2165 FLLVQ 2169
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E R E A AAG + P S ++ + + PPR + + ++ V G ++
Sbjct: 22505 EDHRYEFRVIARNAAGVFSEPSESTGAITARDEV-DPPRISMDPKYKDTIVVHAGESFKV 22563
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
D + G P P ++W +EL N+ + I SL++ +A D+G Y A N+ G
Sbjct: 22564 DADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG 22623
Query: 349 TDSTSAEIYI 358
S + + +
Sbjct: 22624 ERSVTVNVKV 22633
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/94 (30%), Positives = 44/94 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP E+L+N V L C+V G P P+ W + + I + + + GY
Sbjct: 30926 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 30985
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L+I DA Y + A N+ G VS TA L++
Sbjct: 30986 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 31019
Score = 48.5 bits (114), Expect = 4e-05
Identities = 101/438 (23%), Positives = 156/438 (35%), Gaps = 100/438 (22%)
Query: 872 NDDNIRETKNAVIRDLGK--KITFSDVRPNQQEYKISSFEQRLMNEIEFRLE-RTPVDES 928
ND + T++ ++D GK ITF D+ I Q + + E + V E
Sbjct: 11964 NDQRLHTTRSVSMQDEGKTHSITFKDL-------SIDDTSQIRVEAMGMSSEAKLTVLEG 12016
Query: 929 DDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKR 988
D P F +L+ + E V C+I P V WFKDGK+I K
Sbjct: 12017 D---------------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEI-KP 12059
Query: 989 NEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ--GRISCSGHLMVQSLPIRSRLT 1046
+++ ++ +G L ++ D G YT + G++ + P+ S
Sbjct: 12060 SKNAVIKADGKKR-MLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEV 12118
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRL-------CRLD------ 1093
++ R + + E D + LQ P + EG++ CRLD
Sbjct: 12119 METETARFETEISEDDIH-ANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVD 12177
Query: 1094 ---------------CKVSGLPPP-----------------------ELTWLLNGQPVLP 1115
+V GL P + W L G+ + P
Sbjct: 12178 FQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEP 12237
Query: 1116 DASHKMLVRETG-VHSLLIDPLTQRDAGTYKCIATN-KTGQNSFSLELSVVAKEVKKAPV 1173
S K++ R G VH+L + + DAG + A + KT N F VK+ PV
Sbjct: 12238 --SDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----------VKEPPV 12285
Query: 1174 ILEK-LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL 1232
K L++ V EG LEC V V ++K E + + I L+
Sbjct: 12286 EFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRK---LV 12342
Query: 1233 IQPAKKSDAGWYTLSAKN 1250
I D YT AK+
Sbjct: 12343 IHDCTPEDIKTYTCDAKD 12360
Score = 48.5 bits (114), Expect = 4e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT KL+ E V L C + P V+W+ +GKE++ S + I G L +
Sbjct: 12018 PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRMLIL 12076
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+A + D G+Y+C GTD TS ++ IE
Sbjct: 12077 KKALKSDIGQYTCDC----GTDKTSGKLDIE 12103
Score = 48.5 bits (114), Expect = 4e-05
Identities = 54/231 (23%), Positives = 91/231 (39%), Gaps = 22/231 (9%)
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG- 360
W +G+ L +PD I + G +HSL + + TG A+N+ + + + G
Sbjct: 12139 WKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGL 12198
Query: 361 ------VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ 414
V+ + E E++ P E VP+++ V + ++
Sbjct: 12199 LRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVK 12258
Query: 415 QCQSPTNYLQGLDGKP-----IIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ L D K + PV FTK L++ + EG V EC V + KV+W
Sbjct: 12259 LEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEV-SRENAKVKW 12317
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASN 519
++ GT IL+ K + + LVI + ED +TC A +
Sbjct: 12318 FKNGT--------EILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 12360
Score = 48.5 bits (114), Expect = 4e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLEL--SVVAKEVKKAPVI---LEKLQNCGVPEG 1186
+I LTQ ++ A N G S E+ + + PVI LE + G
Sbjct: 26828 IISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAG 26887
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
V+L + G P P W KD++ + + ++TT A +LI+ A + ++G Y L
Sbjct: 26888 TSVKLRAGISGKPAPTIEWYKDDKELQTNA--LVCVENTTDLASILIKDADRLNSGCYEL 26945
Query: 1247 SAKNEAGIVSCTARLDI 1263
+N G S T R+ I
Sbjct: 26946 KLRNAMGSASATIRVQI 26962
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ G+ V V G P PK+EW + T+IE D LQ ++ E L I
Sbjct: 15408 IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD--ALQITKEEVSRSEAKTELSIP 15465
Query: 504 EVFAEDSGCFTCTASNKYGTV 524
+ ED G +T TASN+ G+V
Sbjct: 15466 KAVREDKGTYTVTASNRLGSV 15486
Score = 47.8 bits (112), Expect = 7e-05
Identities = 61/274 (22%), Positives = 105/274 (38%), Gaps = 66/274 (24%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVY----------------WFKDGKQISKRNEHCKMRREGD 999
+ EG+ V F ++ I VP+ Y W+ + ++ ++ R G
Sbjct: 2261 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGR 2320
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+L ++ T +D G Y+ + + +C L ++ PI
Sbjct: 2321 Q--NLTVKDVTKEDQGEYSFVIDGK--KTTCK--LKMKPRPIA----------------- 2357
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP-DAS 1118
LQ D EG + +L+ KVS L E W+ +GQ V P D
Sbjct: 2358 ---------------ILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRV 2401
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
H ++ +++ H LLI+ +T+ DAG Y +L LS + + ++ L
Sbjct: 2402 HIVIDKQS--HMLLIEDMTKEDAGNYSFTIP--------ALGLSTSGRVSVYSVDVITPL 2451
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
++ V EG LEC+V W ++E I
Sbjct: 2452 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI 2485
Score = 47.8 bits (112), Expect = 7e-05
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 34/286 (11%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
FT+ L + EV E ++L C V P +V WY +E+ + I+ G L I
Sbjct: 12465 FTKNLANIEVSETDTIKLVC-EVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQN 12523
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
A ED G Y+C + T ++ + +++ + P E+ +K V S
Sbjct: 12524 AHLEDAGNYNCRLPS----SRTDGKVKVHELAA-EFISKPQNLEILEGEKAEFVCSISKE 12578
Query: 391 SAVIP--------------PAVPQAQHLVAQPRVATIQQCQS---PTNYLQGLDGKPIIA 433
S + + + V + AT+Q + + +I
Sbjct: 12579 SFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE 12638
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
L++ E Q VVF C V K +W+R I DS + ILQK
Sbjct: 12639 KLRIVVPLKDTRVKEQQEVVFNCEVN-TEGAKAKWFRNEEAIFDSSKYIILQK------- 12690
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDL 538
+ + TL I + +D + + +N G V S A L V EDL
Sbjct: 12691 -DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE-EEDL 12734
Score = 47.4 bits (111), Expect = 9e-05
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 6/126 (4%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV--AKEVKKAPVILEKLQNCGVPEGH 1187
SL++ L + ++ A N G S E V AKE P IL Q + G
Sbjct: 18857 SLVVTGLKEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQLLPPKILMPEQ-ITIKAGK 18914
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLS 1247
+R+E V G P P WKK + + T +++H+ + + L+I+ + D+G+Y+L+
Sbjct: 18915 KLRIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSS-SILIIKDVTRKDSGYYSLT 18972
Query: 1248 AKNEAG 1253
A+N +G
Sbjct: 18973 AENSSG 18978
Score = 47.4 bits (111), Expect = 9e-05
Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 9/146 (6%)
Query: 900 QQEYKISSFEQRLMNEIEFR-LERTPVDESDDEIQHDEIPT-GKCIAPIFDKRLKH---F 954
Q+EY + E++ + +FR + RT V+ S D + + + P D +
Sbjct: 19248 QEEYTATGLEEKA--QYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLL 19305
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
V G+ V + G P+P V W KDG + K E KM + + C+L + S D
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLL-KPAEGIKMAMQRN-LCTLELFSVNRKDS 19363
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLP 1040
G+YTI A N G S + L V P
Sbjct: 19364 GDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/158 (25%), Positives = 66/158 (41%), Gaps = 27/158 (17%)
Query: 890 KITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDK 949
K+T +DVR Q +E L E R+E P+ F K
Sbjct: 8800 KLTIADVRAEDQGQYTCKYED-LETSAELRIEAEPIQ--------------------FTK 8838
Query: 950 RLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS-LHIES 1008
R+++ V+E TF C+ V V W+K +++ E K DG C + I +
Sbjct: 8839 RIQNIVVSEHQSATFECE-VSFDDAIVTWYKGPTELT---ESQKYNFRNDGRCHYMTIHN 8894
Query: 1009 TTSDDDGNYTIMA-ANPQGRISCSGHLMVQSLPIRSRL 1045
T DD+G Y+++A P+G + L + + I+ L
Sbjct: 8895 VTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLEL 8932
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/137 (25%), Positives = 50/137 (36%), Gaps = 14/137 (10%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E L++ E R A + A D P + Y EP+ V E
Sbjct: 1808 EGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPV-------------RVLE 1854
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G + C V G P P+V WY G+ + S + G +H L I + DTG
Sbjct: 1855 GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IHYLDIVDCKSYDTGEVKVT 1913
Query: 343 ASNIYGTDSTSAEIYIE 359
A N G ++ I+
Sbjct: 1914 AENPEGVIEHKVKLEIQ 1930
Score = 46.6 bits (109), Expect = 2e-04
Identities = 39/134 (29%), Positives = 55/134 (41%), Gaps = 14/134 (10%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H LE +E + Q ++ SS + L P FT KL + E
Sbjct: 11628 HKLEMKEVTLDDISQIKAQV--------KELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 11679
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+ L C V P V+W+ +G+E+ SP I G L I +A +D G Y C
Sbjct: 11680 ITLKCEVSKDVP--VKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDC-- 11735
Query: 346 IYGTDSTSAEIYIE 359
GTD T A + +E
Sbjct: 11736 --GTDKTKANVTVE 11747
Score = 46.6 bits (109), Expect = 2e-04
Identities = 76/301 (25%), Positives = 114/301 (37%), Gaps = 58/301 (19%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLH 1005
F K L+ V EG+ C+ V KV WFK+G +I K K DG L
Sbjct: 12287 FTKPLEDQTVEEGATAVLECE-VSRENAKVKWFKNGTEILKSK---KYEIVADGRVRKLV 12342
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
I T +D YT A + + SC+ +++ P
Sbjct: 12343 IHDCTPEDIKTYTCDAKD--FKTSCNLNVV-----------------------------P 12371
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
F RP D+ E + R +C++S ++ W +G + + ++ +
Sbjct: 12372 PHVEFLRP-----LTDLQVREKEMARFECELS-RENAKVKWFKDGAEIKKGKKYD-IISK 12424
Query: 1126 TGVHSLLIDPLTQRDAGTYKC-IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V L+I+ D Y C + T +T S L+V+ +E V + L N V
Sbjct: 12425 GAVRILVINKCLLDDEAEYSCEVRTART-----SGMLTVLEEEA----VFTKNLANIEVS 12475
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG-YACLLIQPAKKSDAGW 1243
E ++L C V V ++K D E I R I T G L+IQ A DAG
Sbjct: 12476 ETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEIL----TEGRKRILVIQNAHLEDAGN 12531
Query: 1244 Y 1244
Y
Sbjct: 12532 Y 12532
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 8/97 (8%)
Query: 951 LKHF-RVTEGSPVTFTCKIVGIPVPKVYWFK------DGKQISKRNEHCKMRREGDGTCS 1003
LK F V EG+ V KI G+P P + WFK D K+ + H + D TC+
Sbjct: 16122 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN-KLVVDDTCT 16180
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L I + D G YTI A N G S L V P
Sbjct: 16181 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 16217
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ EG V ++KG P P + W++ D+ + +L + ++ CTLVI
Sbjct: 16126 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKE-PVLYDTHVNKLVVDDTCTLVIP 16184
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ D+G +T TA N GT S +L+V G
Sbjct: 16185 QSRRSDTGLYTITAVNNLGTASKEMRLNVLG 16215
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I LT + ++ A N+ G++ L + V+A++++ P + V +++
Sbjct: 25355 ISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKI 25414
Query: 1192 ECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ G P W+KD +T+ TR +S + T L I+ A K D G Y L N
Sbjct: 25415 DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS---LSIKEASKEDVGTYELCVSN 25471
Query: 1251 EAGIVS 1256
AG ++
Sbjct: 25472 SAGSIT 25477
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/97 (29%), Positives = 45/97 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP + LQ+ V EG E + G P P W +D + I + + G A
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
L I K+++G Y+L A N +G + TA L + A+
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE 100
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/98 (26%), Positives = 39/98 (39%), Gaps = 1/98 (1%)
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L P M +EG R C G P P +TWL GQ + A H++ + + I
Sbjct: 32564 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKY-KSTFEISS 32622
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV 1173
+ D G Y + N G+ L++ V + V
Sbjct: 32623 VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAV 32660
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGR 338
V GT V+ I+ G+P P +W +G E++ + + + V+ N S LTI DTG
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIK-TDEHYTVETDNFSSVLTIKNCLRRDTGE 17580
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y SN G+ + + + +
Sbjct: 17581 YQITVSNAAGSKTVAVHLTV 17600
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P Q L ++V EG VQL+ + V + + W +G+E++ S +HIV H L
Sbjct: 2354 RPIAILQGLSDQKVCEGDIVQLE-VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2412
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I + +ED G YS F G STS + + V D N E + +VS
Sbjct: 2413 LIEDMTKEDAGNYS-FTIPALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSV 2470
Query: 387 PPTTS 391
P TS
Sbjct: 2471 PDVTS 2475
Score = 45.1 bits (105), Expect = 5e-04
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 3/122 (2%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I L Q + +++ A N+ G + L + V+AK++ P V G +++
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 22167
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ IG P P W KDN +P + + T + L I+ A + D G Y + N
Sbjct: 22168 DVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNS 22225
Query: 1252 AG 1253
AG
Sbjct: 22226 AG 22227
Score = 45.1 bits (105), Expect = 5e-04
Identities = 22/80 (27%), Positives = 43/80 (53%)
Query: 277 SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT 336
S V G ++++ + G P P + W +G L+ + I++ + +L +L+I E ++D
Sbjct: 23238 SYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDG 23297
Query: 337 GRYSCFASNIYGTDSTSAEI 356
G+Y +N+ G + S EI
Sbjct: 23298 GQYGITVANVVGQKTASIEI 23317
Score = 45.1 bits (105), Expect = 5e-04
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E +R E A AAG + P S + ++ + + PR + + R+ V G +L
Sbjct: 23587 EDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEV-ELPRISMDPKFRDTIVVNAGETFRL 23645
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ V G P P + W KE+E S I L + +A D G+Y ASN+ G
Sbjct: 23646 EADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 23705
Query: 349 TDSTSAEIYI 358
+ S + +
Sbjct: 23706 SKSFPVNVKV 23715
Score = 44.7 bits (104), Expect = 6e-04
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 2/110 (1%)
Query: 931 EIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE 990
EI + + P D V EG ++ +PVP V W KDGK++ K ++
Sbjct: 14373 EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV-KASD 14431
Query: 991 HCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
M+ + + L + + D G YTI N G + S ++ V LP
Sbjct: 14432 RLTMKND-HISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP 14480
Score = 44.7 bits (104), Expect = 6e-04
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K ++ V G+ V F I G+PVP W DG +I K +EH + + + L I++
Sbjct: 17515 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI-KTDEHYTVETDNFSSV-LTIKN 17572
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y I +N G + + HL V +P
Sbjct: 17573 CLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 17604
Score = 44.3 bits (103), Expect = 8e-04
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSLT 327
P F K S + EG + D VVG P P+ W+ +G+++ N +V + SL
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
I A D+G ++ A N G S S + +E V
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1550
Score = 44.3 bits (103), Expect = 8e-04
Identities = 34/136 (25%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 1144 YKCIATNKTG-----QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
++ A N+TG + + S++ + + E AP I +++++ G +L C+++G
Sbjct: 30503 FRVFAENETGLSRPRRTAMSIKTKLTSGE---APGIRKEMKDVTTKLGEAAQLSCQIVGR 30559
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W + + + +R + M D + L + ++ D G YT A NE G V +
Sbjct: 30560 PLPDIKWYRFGKELIQSR-KYKMSSDGRTHT-LTVMTEEQEDEGVYTCIATNEVGEVETS 30617
Query: 1259 ARLDIYA--QWHHQIP 1272
++L + A Q+H P
Sbjct: 30618 SKLLLQATPQFHPGYP 30633
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/201 (21%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
V W + KE++ S I G ++ LT+ ++D G+Y+ +A G + TS ++ +
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYA----GENMTSGKLTVA 2618
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSP-------------PTTSAVIPPAVPQAQHL-V 405
G + S D E EV++P P T+ + + + L +
Sbjct: 2619 GGAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 2678
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
A ++ I + K + A K L+NL+ +E Q VF +
Sbjct: 2679 AATKLDDIGEYTYKV-ATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKG 2737
Query: 466 VEWYREGTLIEDSPDFRILQK 486
V+W + G ++E + + I K
Sbjct: 2738 VQWIKNGVVLESNEKYAISVK 2758
Score = 43.5 bits (101), Expect = 0.001
Identities = 50/228 (21%), Positives = 86/228 (37%), Gaps = 42/228 (18%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P +++ L+ + EG T TC+ +P K WF++G+ + + H K E
Sbjct: 8743 IEPAWERHLQDVTLKEGQTCTMTCQF-SVPNVKSEWFRNGRILKPQGRH-KTEVE-HKVH 8799
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L I ++D G YT + + S L +++ PI+
Sbjct: 8800 KLTIADVRAEDQGQYTCKYED----LETSAELRIEAEPIQ-------------------- 8835
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F + ++V E + +C+VS +TW G L ++
Sbjct: 8836 ------------FTKRIQNIVVSEHQSATFECEVS-FDDAIVTW-YKGPTELTESQKYNF 8881
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIA-TNKTGQNSFSLELSVVAKEVK 1169
+ H + I +T D G Y IA G+ + EL + KE+K
Sbjct: 8882 RNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIK 8929
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/288 (20%), Positives = 109/288 (37%), Gaps = 39/288 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F L +V E + +C V P RW +E+ +++ G HS+
Sbjct: 11839 PLIFITPLSDVKVFEKDEAKFEC-EVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMV 11897
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-----------VSSSDSEGDPNKEEMN 376
I A ED +Y A + + TS ++ IEG V++ + E E++
Sbjct: 11898 IKSAAFEDEAKYMFEAEDKH----TSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELS 11953
Query: 377 ----RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPII 432
R++ TT +V + + + +I G+ + +
Sbjct: 11954 HDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKD--LSIDDTSQIRVEAMGMSSEAKL 12011
Query: 433 AA----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
P FT LQ+ + E V+ +C + A +P V+W+++G I+ S + I
Sbjct: 12012 TVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGK 12070
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ M L++ + D G +TC GT + +L + E
Sbjct: 12071 KRM--------LILKKALKSDIGQYTCDC----GTDKTSGKLDIEDRE 12106
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 31/258 (12%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V G DC + P V WY +GK+LE S + G +H+LT+ + E
Sbjct: 12202 LKDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 12260
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIE--GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSA 392
D G A + T A ++++ V + D EE EVS
Sbjct: 12261 DAGEVQLTAKDF----KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 12316
Query: 393 VIPPAV----PQAQHLVAQPRV--ATIQQCQSPTNYLQGLDGKPI-------IAAP--VF 437
+ +VA RV I C D K + P F
Sbjct: 12317 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEF 12376
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
+ L +L E ++ FEC + + KV+W+++G I+ + I+ K +
Sbjct: 12377 LRPLTDLQVREKEMARFECEL-SRENAKVKWFKDGAEIKKGKKYDIISK--------GAV 12427
Query: 498 CTLVIAEVFAEDSGCFTC 515
LVI + +D ++C
Sbjct: 12428 RILVINKCLLDDEAEYSC 12445
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 5/121 (4%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +T+ ++ R GT V+L + G P P + WY + KEL+ + + + +L S+
Sbjct: 26875 PLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL 26931
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I +A ++G Y N G S SA I ++ + G P + + +K + P
Sbjct: 26932 IKDADRLNSGCYELKLRNAMG--SASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRP 26989
Query: 388 P 388
P
Sbjct: 26990 P 26990
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYK 1145
G RL VSG PPP +TW G D + + ++ T +SLLI D + + DAG Y
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQG----IDLASRAIIDTTESYSLLIVDKVNRYDAGKYT 29516
Query: 1146 CIATNKTGQNSFSLELSV 1163
A N++G+ S ++ + V
Sbjct: 29517 IEAENQSGKKSATVLVKV 29534
Score = 43.1 bits (100), Expect = 0.002
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVILEKLQ---NCGVPEGH 1187
+ LT+ A ++ IA N G S E S + ++ +AP I ++ + G
Sbjct: 21418 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 21477
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G PPP W KD + + T + I + +T L+ + + + D+G YTL
Sbjct: 21478 AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN---LVNKDSTRRDSGAYTL 21534
Query: 1247 SAKNEAG 1253
+A N G
Sbjct: 21535 TATNPGG 21541
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 3/103 (2%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
A G +P S PS + P+ ++ ++ + G +L+ V G PPP + W
Sbjct: 21436 AAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEW 21495
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+GKELE + + I A +L ++ D+G Y+ A+N
Sbjct: 21496 SKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATN 21538
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/211 (22%), Positives = 78/211 (36%), Gaps = 18/211 (8%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V EGT+ L+C V V+WY ++++ + + G L I
Sbjct: 2451 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHAS 2510
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPT----- 389
D G Y I G T+ + +E + D E + E+S
Sbjct: 2511 DEGPYKL----IVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2566
Query: 390 -TSAVIPPAVP---QAQHLVAQPRVAT-IQQCQSPTNYLQG---LDGKPIIAAPVFTKML 441
I P+ +A + + V ++ + + G GK +A +K L
Sbjct: 2567 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPL 2626
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
+ + +E Q VFEC V P K EW R+G
Sbjct: 2627 TDQTVAESQEAVFECEVAN-PDSKGEWLRDG 2656
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD- 1140
+V H G + R+ VSG PPP +TW +N + + +A+ + T + S ++ QR
Sbjct: 16534 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEAT----IETTAISSSMVIKNCQRSH 16589
Query: 1141 AGTYKCIATNKTGQNSFSLELSVV 1164
G Y +A N+ G+ ++ + V+
Sbjct: 16590 QGVYSLLAKNEAGERKKTIIVDVL 16613
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 8/125 (6%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCG----VPEGHPVRLECRVIGM 1198
++ A N G+ L SV+AK++ P + E C V G +R+ RV G
Sbjct: 17877 FRIKAANIVGEGEPRELAESVIAKDILHPPEV-ELDVTCRDVITVRVGQTIRILARVKGR 17935
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W K+ + + +R+ + QD L I+ A ++D G Y +SAKN +G +
Sbjct: 17936 PEPDITWTKEGKVL-VREKRVDLIQDLPRVE-LQIKEAVRADHGKYIISAKNSSGHAQGS 17993
Query: 1259 ARLDI 1263
A +++
Sbjct: 17994 AIVNV 17998
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/90 (21%), Positives = 44/90 (48%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P + + G ++++ V+G P P + W +G+ L+ + +++ + L I
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 24371
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
E ++D G+Y+ A+N GT + + + +
Sbjct: 24372 KEGNKDDFGKYTVTATNSAGTATENLSVIV 24401
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 248 GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVP--EGTRVQLDCIVVGIPPPQVRWYCE 305
G + P + SS+ +EP +P + ++ + G+ +D + G P P+V W E
Sbjct: 28625 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 28684
Query: 306 GKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
L+ + + I + +LT+ ++ D+GRY N G + S + + G
Sbjct: 28685 EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 28739
Score = 42.0 bits (97), Expect = 0.004
Identities = 42/181 (23%), Positives = 75/181 (41%), Gaps = 11/181 (6%)
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
TW+ +G + H+ + +ID + DAG Y C+ + + + +L V
Sbjct: 11150 TWMKDGSNIRESPKHRFIADGKDRKLHIID-VQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208
Query: 1165 AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
V+ + E++ V +G P+ L C + V W+KD + + RI
Sbjct: 11209 ELPVRFVKTLEEEVT---VVKGQPLYLSCELNKERDVV--WRKDGKIVVEKPGRIV--PG 11261
Query: 1225 TTGYA-CLLIQPAKKSDAGWYTLSAKNEAGI--VSCTARLDIYAQWHHQIPPPMSVRPSG 1281
G L I A +DAG YT++ +N + SC +++ W + V+P G
Sbjct: 11262 VIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKG 11321
Query: 1282 S 1282
+
Sbjct: 11322 T 11322
Score = 42.0 bits (97), Expect = 0.004
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 16/165 (9%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E + E A AG + P S ++ ++ P P L + G +
Sbjct: 20340 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLT---IKAGDTI 20396
Query: 287 QLDCI-VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ I ++G P P+ W GK++ S I LTI A +D G Y+ A+N
Sbjct: 20397 VLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATN 20456
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI--QKPNEVSSPP 388
+GT ++ + D G P E++ + +K +PP
Sbjct: 20457 PFGTKVEHVKVTV-----LDVPGPPGPVEISNVSAEKATLTWTPP 20496
Score = 42.0 bits (97), Expect = 0.004
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 2/84 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + G + ++G P P + W KDG+ + K+ + T
Sbjct: 24310 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPL-KQTTRVNVEETATSTV 24368
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
LHI+ DD G YT+ A N G
Sbjct: 24369 -LHIKEGNKDDFGKYTVTATNSAG 24391
Score = 41.6 bits (96), Expect = 0.005
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V G V L+ V G P P WKKD + P +++M ++ L + + D+
Sbjct: 19307 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CTLELFSVNRKDS 19363
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
G YT++A+N +G S T +L + + PP SV+
Sbjct: 19364 GDYTITAENSSGSKSATIKLKVL----DKPGPPASVK 19396
Score = 41.6 bits (96), Expect = 0.005
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
LD V G P P ++W +G + P KM + + + +L + + ++D+G Y A N
Sbjct: 19315 LDATVFGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENS 19373
Query: 1152 TGQNSFSLELSVVAKEVKKAPVILEKL 1178
+G S +++L V+ K A V + K+
Sbjct: 19374 SGSKSATIKLKVLDKPGPPASVKINKM 19400
Score = 41.2 bits (95), Expect = 0.007
Identities = 74/335 (22%), Positives = 131/335 (39%), Gaps = 58/335 (17%)
Query: 922 RTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
R P +D +++ E+ A F + ++ + EG F C I P V W +D
Sbjct: 12535 RLPSSRTDGKVKVHEL------AAEFISKPQNLEILEGEKAEFVCSISKESFP-VQWKRD 12587
Query: 982 GKQISKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHL-MVQSL 1039
K + +++ + DG L ++ T D G Y +M G + HL +++ L
Sbjct: 12588 DKTLESGDKYDVI---ADGKKRVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKL 12640
Query: 1040 PIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGL 1099
I L +RV+E+ QE F +C+V+
Sbjct: 12641 RIVVPLKD--------TRVKEQ-----QEVVF---------------------NCEVN-T 12665
Query: 1100 PPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL 1159
+ W N + + D+S +++++ V++L I D Y TN G+N S
Sbjct: 12666 EGAKAKWFRNEEAIF-DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 12724
Query: 1160 ELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+V +E + I+E L++ E V C+V + W K+ E +P R+
Sbjct: 12725 ANLIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGEEVPFD-NRV 12779
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
S D + L I+ D G Y ++A + +
Sbjct: 12780 SYRVDKYKH-MLTIKDCGFPDEGEYIVTAGQDKSV 12813
Score = 41.2 bits (95), Expect = 0.007
Identities = 29/102 (28%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
+VVAK+ P I + + V EG + + +P P W KD + + + +R++M
Sbjct: 14377 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKAS-DRLTM 14435
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
D A L + + ++DAG YT++ +N+ G S TA +++
Sbjct: 14436 KNDHIS-AHLEVPKSVRADAGIYTITLENKLG--SATASINV 14474
Score = 40.8 bits (94), Expect = 0.009
Identities = 22/79 (27%), Positives = 36/79 (45%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V GT+++L V G P P++ W L+ I I ++TI ++ DTG Y
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Query: 340 SCFASNIYGTDSTSAEIYI 358
A N+ G + E+ +
Sbjct: 13762 IIEAVNVCGRATAVVEVNV 13780
Score = 40.8 bits (94), Expect = 0.009
Identities = 31/136 (22%), Positives = 59/136 (43%), Gaps = 5/136 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
++ L + ++ A N G + S + + P ++ + V EG V +
Sbjct: 16078 VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIV 16137
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQP-AKKSDAGWYTLS 1247
++ G+P P W K P +E + +++ C L+ P +++SD G YT++
Sbjct: 16138 AKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT 16197
Query: 1248 AKNEAGIVSCTARLDI 1263
A N G S RL++
Sbjct: 16198 AVNNLGTASKEMRLNV 16213
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +R+ V G PPP W + T+P + + + T + ++I+ ++S G
Sbjct: 16536 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLP----QEATIETTAISSSMVIKNCQRSHQG 16591
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
Y+L AKNEAG T +D+
Sbjct: 16592 VYSLLAKNEAGERKKTIIVDV 16612
Score = 40.8 bits (94), Expect = 0.009
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 9/126 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E +R E A AAG + P S ++ + + P P++ + V G
Sbjct: 24669 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVI---VVHAGETF 24725
Query: 287 QLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ + G P P V W +GKEL E + + I +L + + D G+Y SN
Sbjct: 24726 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 24785
Query: 346 IYGTDS 351
+ GT S
Sbjct: 24786 VGGTKS 24791
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGN 322
+P + P T +++RE ++++D G P V W +G+ L+ + +++ +
Sbjct: 25394 KPSVELPFHTFNVKARE-----QLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT 25448
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ SL+I EA +ED G Y SN G+ + I +
Sbjct: 25449 VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIV 25484
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGHPVR 1190
L+ D ++ IA N G S + S ++ ++ P++ E + G +R
Sbjct: 27918 LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLR 27977
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMH-QDTTGYACLLIQPAKKSDAGWYTLSAK 1249
++ V G P P W KD I +R++M D G L ++ A + G YT+ AK
Sbjct: 27978 IKALVQGRPVPRVTWFKDGVEI---EKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAK 28034
Query: 1250 NEAGIVSCTARLDI 1263
N +G ++ +
Sbjct: 28035 NASGSAKAEIKVKV 28048
Score = 40.8 bits (94), Expect = 0.009
Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
+ G +++ +V G P P+V W+ +G E+E ++ I SL + +A + G Y
Sbjct: 27970 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 28029
Query: 340 SCFASNIYGTDSTSAEIYIE 359
+ A N G S AEI ++
Sbjct: 28030 TVEAKNASG--SAKAEIKVK 28047
Score = 40.4 bits (93), Expect = 0.011
Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 26/236 (11%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV--RWYCEGKELENSPDIHIVQAGNL 323
G F ++L+ EVPE +L+CIV P + +WY EL+++ I
Sbjct: 2264 GAVVEFVKELQDIEVPESYSGELECIV---SPENIEGKWYHNDVELKSNGKYTITSRRGR 2320
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAE----IYIEGVSSSD-SEGDPNKEEMN-- 376
+LT+ + +ED G YS T + ++G+S EGD + E+
Sbjct: 2321 QNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVS 2380
Query: 377 -------RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--D 427
++ EV VI Q+ L+ + S T GL
Sbjct: 2381 LESVEGVWMKDGQEVQPSDRVHIVID---KQSHMLLIEDMTKEDAGNYSFTIPALGLSTS 2437
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
G+ + + L++++ EG V EC+V V+WY I+ PD R+
Sbjct: 2438 GRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIK--PDDRV 2491
Score = 40.4 bits (93), Expect = 0.011
Identities = 24/97 (24%), Positives = 40/97 (41%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + EG +T C G P P+V W G++I + + D
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 33386
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
+L I D G YT+ N G S + ++ ++S+
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 33423
Score = 40.0 bits (92), Expect = 0.015
Identities = 74/343 (21%), Positives = 115/343 (33%), Gaps = 52/343 (15%)
Query: 558 PQPSPPHSEPPSV--EQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEA 615
P P EPP+ E P K +E + EPR +PE E E
Sbjct: 10456 PTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPT-------KVPEVLPPKEVVPEK 10508
Query: 616 GVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQH 675
V +P++ + +A K P V PPP KP++ T++ ++ + E+
Sbjct: 10509 KVPVPPAKKPEAPPPKVP-EAPKEVVPEKKVPVPPP--KKPEVPPTKVPEVPKAAVPEKK 10565
Query: 676 QLQNPPP---SSPKEFPFS-MTVLNSNAPPAVTTSSKQV---KAPSSQTFSLARPKYFFP 728
+ PP S P E P + V+ PA +V K P + PK P
Sbjct: 10566 VPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEA-------PKEVVP 10618
Query: 729 STNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGL---------- 778
V P P + P+ + V ++ + + P P +
Sbjct: 10619 EKKVP---VPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALE 10675
Query: 779 ----SIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQN------PVA 828
+ EP P P + T PP P + P V+ P P ++ P
Sbjct: 10676 EPPAEVVEEPEPAAPPQVTVPP---KKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEK 10732
Query: 829 FLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPV 871
+ V+P P PP +P+ + KK P V
Sbjct: 10733 KVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKV 10775
Score = 40.0 bits (92), Expect = 0.015
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 10/93 (10%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLL-------NGQPVLPDAS-HKMLVRETGVHSLLI 1133
M EG + K+ G+P P LTW N +PVL D +K++V +T +L+I
Sbjct: 16126 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVI 16183
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
+ D G Y A N G S + L+V+ +
Sbjct: 16184 PQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 16216
Score = 40.0 bits (92), Expect = 0.015
Identities = 34/140 (24%), Positives = 61/140 (43%), Gaps = 8/140 (5%)
Query: 231 QEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+E K+ + AA A G + P + +E L PP+ + G +++++
Sbjct: 18864 KEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQL-LPPKILMP-EQITIKAGKKLRIEA 18920
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
V G P P +W E+ S + + +A + L I + +D+G YS A N GTD
Sbjct: 18921 HVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD 18980
Query: 351 STSAEIYIEGVSSSDSEGDP 370
+ ++ + D+ G P
Sbjct: 18981 TQKIKVVV-----MDAPGPP 18995
Score = 40.0 bits (92), Expect = 0.015
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
++ G RL+ VSG PPP + W +G+ + A ++ + + +L+ T+RD+
Sbjct: 21471 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDS 21529
Query: 1142 GTYKCIATNKTG 1153
G Y ATN G
Sbjct: 21530 GAYTLTATNPGG 21541
Score = 40.0 bits (92), Expect = 0.015
Identities = 23/81 (28%), Positives = 36/81 (44%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F + V G +++D +G P P V W+ + L+ + ++ N LT
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 22206
Query: 328 IAEAFEEDTGRYSCFASNIYG 348
I +A ED G Y +N G
Sbjct: 22207 IKDACREDVGHYVVKLTNSAG 22227
Score = 39.7 bits (91), Expect = 0.019
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 8/110 (7%)
Query: 242 ASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVR 301
A AG T+ G E + +P + ++ +V G L+ V G P + +
Sbjct: 3998 AENEAGSQTSVG--------ELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPK 4049
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDS 351
WY +G+ L S I N+ L A D+G+Y+ SN G+ S
Sbjct: 4050 WYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSS 4099
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 10/121 (8%)
Query: 1139 RDAGTYK--CIATNKTGQNSFS-LELSVVAKEVKKAPVIL---EKLQNCGVPEGHPVRLE 1192
RD TYK +A N G++ + + V+ K+ + P ++ + + G +RL
Sbjct: 17180 RDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLS 17239
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ G+P P WKK++ P T+ RI + T + L I+ A D G Y+L+ +N A
Sbjct: 17240 AIIKGVPFPKVTWKKEDRDAP-TKARIDV---TPVGSKLEIRNAAHEDGGIYSLTVENPA 17295
Query: 1253 G 1253
G
Sbjct: 17296 G 17296
Score = 39.7 bits (91), Expect = 0.019
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
+E+ P L P + G+ R++ V G P P W G+ + +SH + +
Sbjct: 18894 KEQLLPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKAD 18951
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
L+I +T++D+G Y A N +G ++ +++ V+
Sbjct: 18952 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVM 18989
Score = 39.7 bits (91), Expect = 0.019
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
VP G PV L + G PPP W + ER+++ + T A L I+ D G
Sbjct: 29750 VPAGRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTG 29807
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
YTL KN G S T ++ I
Sbjct: 29808 EYTLELKNVTGTTSETIKVII 29828
Score = 39.7 bits (91), Expect = 0.019
Identities = 68/316 (21%), Positives = 110/316 (34%), Gaps = 54/316 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG-DGTC 1002
AP R++ RV G F + P +V W+ +G ++ E K+ G
Sbjct: 32373 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ---ESSKIHYTNTSGVL 32429
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I +DD G Y + N +G S L V + + Q RD
Sbjct: 32430 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYAS------------QRRD 32477
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
+E + F P + V+ + ++ S
Sbjct: 32478 EEVPRSVF--PELTRTEAYAVSSFKKTSEMEASSS------------------------- 32510
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ-NSFSLELSVVAKEVKK--APVILEKLQ 1179
VRE V S + + + + A K+ SLE +++K A IL K +
Sbjct: 32511 VRE--VKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR 32568
Query: 1180 NCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG--YACLLIQPAK 1237
+ V EG R C G P P W + + + + + HQ TT + I +
Sbjct: 32569 SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS----ARHQVTTTKYKSTFEISSVQ 32624
Query: 1238 KSDAGWYTLSAKNEAG 1253
SD G Y++ +N G
Sbjct: 32625 ASDEGNYSVVVENSEG 32640
Score = 39.3 bits (90), Expect = 0.025
Identities = 38/141 (26%), Positives = 57/141 (40%), Gaps = 17/141 (12%)
Query: 242 ASEAAGGDTTPGSSPSSLYYEEPLGQPPR----------FTQKLRSREVPEGTRVQLDCI 291
AS AG DTT ++P P F + +S V E T
Sbjct: 8420 ASNVAGSDTTKSKVTIK---DKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAK 8476
Query: 292 VVGIPPPQVRWYCEGK--ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
V G P P V+W +GK +L + I Q G+ L I + + D+G Y C A N +G
Sbjct: 8477 VGGDPIPNVKW-TKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGE 8535
Query: 350 DSTSAEIYIEGVSSSDS-EGD 369
++ + ++ + EGD
Sbjct: 8536 IESNVNLQVDERKKQEKIEGD 8556
Score = 39.3 bits (90), Expect = 0.025
Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 11/127 (8%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSR---EVPEGTRVQLDCI 291
R A AA E G+T P + EP +PP + + ++ G +++ +
Sbjct: 15075 RVSAVNAAGEGPPGETQP------VTVAEPQ-EPPAVELDVSVKGGIQIMAGKTLRIPAV 15127
Query: 292 VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDS 351
V G P P W E EL+ + I G L I +A +D GRY A+N G+
Sbjct: 15128 VTGRPVPTKVWTKEEGELDKDRVV-IDNVGTKSELIIKDALRKDHGRYVITATNSCGSKF 15186
Query: 352 TSAEIYI 358
+A + +
Sbjct: 15187 AAARVEV 15193
Score = 38.9 bits (89), Expect = 0.033
Identities = 62/298 (20%), Positives = 114/298 (38%), Gaps = 61/298 (20%)
Query: 951 LKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
LK V EG+ CK+ V V W+ + +QI K ++ + +G L I T
Sbjct: 2451 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI-KPDDRVQAIVKGTKQ-RLVINRTH 2508
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
+ D+G Y ++ GR+ + +L V+ + I
Sbjct: 2509 ASDEGPYKLIV----GRVETNCNLSVEKIKI----------------------------- 2535
Query: 1071 FRPHFLQAPGDMVAHEGR--LCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ D+ E + + ++ SG+ ++ W + + P + +K + +
Sbjct: 2536 -----IRGLRDLTCTETQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYK-IEAHGKI 2586
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
+ L + + + D G Y T G+N S +L+V + K L + V E
Sbjct: 2587 YKLTVLNMMKDDEGKY----TFYAGENMTSGKLTVAGGAISK------PLTDQTVAESQE 2636
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY-ACLLIQPAKKSDAGWYT 1245
EC V P W +D + +P T ++ ++ G+ L+I K D G YT
Sbjct: 2637 AVFECEVAN-PDSKGEWLRDGKHLPLTN---NIRSESDGHKRRLIIAATKLDDIGEYT 2690
Score = 38.9 bits (89), Expect = 0.033
Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 40/222 (18%)
Query: 814 PIPVSPTSRIQNPVAFLSSVLPSLPAIPP---------TNAMGLPRSAPSMPSQGLAKKN 864
P SP R ++PV LPS P+ P T A P P G +
Sbjct: 26068 PSETSPLIRAEDPV-----FLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEY 26122
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTP 924
KS DD +T +R G + T S + + F + +N++ P
Sbjct: 26123 KKS-----DDTDWKTSIQSLR--GTEYTISGLTTGAEYV----FRVKSVNKVG---ASDP 26168
Query: 925 VDESDDEIQHDEIPTGKCIAPIFD---KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
D SD +I + P+FD + K V G+ T T G PVP V W K
Sbjct: 26169 SDSSDPQIAKEREEE-----PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKP 26223
Query: 982 GKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAAN 1023
+ R D SL IE+ +D G YT+ N
Sbjct: 26224 DTDLRTR----AYVDTTDSRTSLTIENANRNDSGKYTLTIQN 26261
Score = 38.9 bits (89), Expect = 0.033
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 5/80 (6%)
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS-LLIDPLTQRDAGTY 1144
+G + RL + G P P W GQ D S + ++ + H+ L+I + D+GTY
Sbjct: 30150 QGGVIRLTIPIKGKPFPICKWTKEGQ----DISKRAMIATSETHTELVIKEADRGDSGTY 30205
Query: 1145 KCIATNKTGQNSFSLELSVV 1164
+ NK G+ + +++ V+
Sbjct: 30206 DLVLENKCGKKAVYIKVRVI 30225
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 8/114 (7%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT +Q +D + + K+L L+ G + V G P PK+ W +
Sbjct: 13675 PTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTK-------- 13726
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
D + Q K ++ + T+ I + D+G + A N G +++ +++V
Sbjct: 13727 ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 13780
Score = 38.5 bits (88), Expect = 0.043
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +RL G P P W K + + R +H T ++ L ++ ++DAG
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL---RADIHT-TDSFSTLTVENCNRNDAG 28424
Query: 1243 WYTLSAKNEAGIVSCT 1258
YTL+ +N +G S T
Sbjct: 28425 KYTLTVENNSGSKSIT 28440
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 5/96 (5%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G+ + LD V G P P++ W KEL+ + + G + I D+G+Y+
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLT 29121
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
N GT + S + + DS G K ++R+
Sbjct: 29122 VKNASGTKAVSVMVKV-----LDSPGPCGKLTVSRV 29152
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/154 (21%), Positives = 71/154 (46%), Gaps = 16/154 (10%)
Query: 1144 YKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKL--QNCGVPE-GHPVRLECRVIGMP 1199
++ A N+ G++ S + A ++++ P + + Q+C V + G +R+ + G P
Sbjct: 15779 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 15838
Query: 1200 PPVFYWKKDNETIPCTRERI------SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
P W+ D + ++ + + + + ++I K+S G Y+++AKN+AG
Sbjct: 15839 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 15898
Query: 1254 IVSCTARLDIYAQWHHQIP-PPMSVRPSGSRYGS 1286
+ R+ + +P PP ++ S GS
Sbjct: 15899 QKTANCRVKVM-----DVPGPPKDLKVSDITRGS 15927
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 9/122 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWY-C 304
A G + P ++ + P PP K EV EGT V + + G+P P + W+
Sbjct: 16096 AAGVSKPSATVGPCDCQRP-DMPPSIDLK-EFMEVEEGTNVNIVAKIKGVPFPTLTWFKA 16153
Query: 305 EGKELENSP----DIHI--VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
K+ +N D H+ + + +L I ++ DTG Y+ A N GT S + +
Sbjct: 16154 PPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 16213
Query: 359 EG 360
G
Sbjct: 16214 LG 16215
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/142 (23%), Positives = 65/142 (45%), Gaps = 10/142 (7%)
Query: 1121 MLVRETGVH--SLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVI--- 1174
M TG++ ++ ++ L ++ ++ A NK G + + ++ +E +AP I
Sbjct: 22886 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 22945
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
LE + + G +RL + G P P W K + I ++ T+ + L++
Sbjct: 22946 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI----RDAAIIDVTSSFTSLVLD 23001
Query: 1235 PAKKSDAGWYTLSAKNEAGIVS 1256
+ D+G YTL+ +N +G S
Sbjct: 23002 NVNRYDSGKYTLTLENSSGTKS 23023
Score = 38.1 bits (87), Expect = 0.056
Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 24/126 (19%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRD 1140
+V + G RL+ V G P P + WL + + + S + ++ T +LLI + D
Sbjct: 23635 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEI--EESARCEIKNTDFKALLIVKDAIRID 23692
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL------ECR 1194
G Y A+N G SF PV ++ L G PEG PV++ +C
Sbjct: 23693 GGQYILRASNVAGSKSF--------------PVNVKVLDRPGPPEG-PVQVTGVTSEKCS 23737
Query: 1195 VIGMPP 1200
+ PP
Sbjct: 23738 LTWSPP 23743
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
GR L ++G PPP +W G L ++ + T V L I T RD G Y
Sbjct: 29753 GRPVELVIPIAGRPPPAASWFFAGSK-LRESERVTVETHTKVAKLTIRETTIRDTGEYTL 29811
Query: 1147 IATNKTGQNSFSLELSVVAK 1166
N TG S ++++ ++ K
Sbjct: 29812 ELKNVTGTTSETIKVIILDK 29831
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 448 EGQLVVFECRVKGAP-SPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG V + C+++ S +V WY +E+S + I + + + L + ++
Sbjct: 31581 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYE--------DGVAILYVKDIT 31632
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHVRG 534
D G + C N YG SS A+L V+G
Sbjct: 31633 KLDDGTYRCKVVNDYGEDSSYAELFVKG 31660
Score = 37.7 bits (86), Expect = 0.073
Identities = 63/288 (21%), Positives = 101/288 (35%), Gaps = 38/288 (13%)
Query: 557 EPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAG 616
E P P S PP V + PK + V P+ ++V PE K E E
Sbjct: 10568 EAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKV----PEAPK--EVVPEKK 10621
Query: 617 VVTTRQTRPDSFQERFNGQATKTPE-PSSPVKE---PPPVLAKPKLDSTQLQQLHNQVLL 672
V +P+ TK PE P V E P + KP+ ++ + +V L
Sbjct: 10622 VPVPPPKKPEV-------PPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVAL 10674
Query: 673 EQ---HQLQNPPPSSPKE--FPFSMTVLNSNAPPAVTTSSK--QVKAPSSQTFSLARPKY 725
E+ ++ P P++P + P V AP V + VK P PK
Sbjct: 10675 EEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEV-------PKE 10727
Query: 726 FFPSTNTTAATVAPSSSPVFTLSSTPQTI--QRTVSKESLLVSHPSVQTKSPGGLSIQNE 783
P +P + P+ + ++ V+ P+ + P ++ +
Sbjct: 10728 VVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEK 10787
Query: 784 PLPPGPTE-PTPPPFTFSIPS----GNQFQPRCVSPIPVSPTSRIQNP 826
P P P +PPP + P + P P+PV+ + P
Sbjct: 10788 PAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVP 10835
Score = 37.7 bits (86), Expect = 0.073
Identities = 60/224 (26%), Positives = 88/224 (39%), Gaps = 25/224 (11%)
Query: 157 FIEELSSLFK-SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPI 215
F E L+ L K S SS I+ AC+ K N +++ S +DL + S PI
Sbjct: 17778 FAENLAGLSKPSPSSDPIK--ACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPI 17835
Query: 216 ---------PADTRDNEVNH-ALEQQEAKRREAEQAASE------AAG--GDTTPGSSPS 257
P + N +N L +Q A R +E AA G+ P
Sbjct: 17836 LGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAE 17895
Query: 258 SLYYEEPLGQPPRFTQKLRSREVPE---GTRVQLDCIVVGIPPPQVRWYCEGKELENSPD 314
S+ ++ L PP + R+V G +++ V G P P + W EGK L
Sbjct: 17896 SVIAKDIL-HPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKR 17954
Query: 315 IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ ++Q L I EA D G+Y A N G SA + +
Sbjct: 17955 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 17998
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 8/84 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
GQ + RVKG P P + W +EG ++ ++Q PR L I E
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPR--------VELQIKEAVRA 17974
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
D G + +A N G A ++V
Sbjct: 17975 DHGKYIISAKNSSGHAQGSAIVNV 17998
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ +++ +SG P P +TW +G P L + + + +L I + D G Y
Sbjct: 23244 GQDLKIEVPISGRPKPTITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 23302
Query: 1147 IATNKTGQNSFSLELSVVAK-EVKKAPV 1173
N GQ + S+E+ + K + K PV
Sbjct: 23303 TVANVVGQKTASIEIVTLDKPDPPKGPV 23330
Score = 37.4 bits (85), Expect = 0.096
Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 5/91 (5%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P + + L+ + EG + C +P + W+ G+ L+ +H LTI
Sbjct: 8745 PAWERHLQDVTLKEGQTCTMTC-QFSVPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTI 8803
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
A+ ED G+Y+C ++ TSAE+ IE
Sbjct: 8804 ADVRAEDQGQYTCKYEDL----ETSAELRIE 8830
Score = 37.4 bits (85), Expect = 0.096
Identities = 51/244 (20%), Positives = 86/244 (35%), Gaps = 32/244 (13%)
Query: 638 KTPEPSS---PVKEPPPVLAKPKLDSTQLQQLHNQVLLEQ-----HQLQNPPPSSPKEFP 689
K PE S P K+PP + K ++ ++ ++++E+ + + PP P+ P
Sbjct: 10441 KGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLP 10500
Query: 690 FSMTVLNSNAP--PAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTL 747
V P PA + K P + PK P V P P
Sbjct: 10501 PKEVVPEKKVPVPPAKKPEAPPPKVPEA-------PKEVVPEKKVP---VPPPKKPEVPP 10550
Query: 748 SSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQF 807
+ P+ + V ++ + + P P +P P E P +P+
Sbjct: 10551 TKVPEVPKAAVPEKKVPEAIPPKPESPP-------PEVPEAPKEVVPEK---KVPAAPPK 10600
Query: 808 QPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSA-PSMPSQGLAKKNTK 866
+P V+P+ V + P + P P +PPT +P+ A P +
Sbjct: 10601 KPE-VTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPE 10659
Query: 867 SPQP 870
SP P
Sbjct: 10660 SPPP 10663
Score = 37.4 bits (85), Expect = 0.096
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 17/164 (10%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W+ ++P+ ++K+ E G L Y+ A NK G + S L +
Sbjct: 13338 WIRCNMKLVPELTYKVTGLEKGNKYL------------YRVSAENKAGVSDPSEILGPLT 13385
Query: 1166 KE---VKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+ V+ + V +P+ + G P P W ++ + T +R+ M
Sbjct: 13386 ADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLE-TGDRVKM- 13443
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ + YA L+I P+++SD G YTL +N +S +++ A+
Sbjct: 13444 KTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR 13487
Score = 37.4 bits (85), Expect = 0.096
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDAGWY 1244
G +RL V G PPP W K N + R+RI + +T + L + K DAG Y
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNL---RDRIGLDIKSTDFDTFLRCENVNKYDAGKY 19764
Query: 1245 TLSAKNEAG 1253
L+ +N G
Sbjct: 19765 ILTLENSCG 19773
Score = 37.4 bits (85), Expect = 0.096
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVI-LEKLQNCGV--PEGHPVRLECRVIGMP 1199
++ A N GQ + V AK++ +AP I L+ V G V++ G P
Sbjct: 27240 FRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRP 27299
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
PP W+KD + + + R S+ ++T + L I ++D G Y L+ +N G
Sbjct: 27300 PPTVTWRKDEKNLG-SDARYSI-ENTDSSSLLTIPQVTRNDTGKYILTIENGVG 27351
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 21/140 (15%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEP-----LGQPPRFTQKLRSREVPEGTRVQLD 289
R +A A E+ DTT G P++ EEP +G K G+++++
Sbjct: 15780 RVKAVNEAGESEPSDTT-GEIPATDIQEEPEVFIDIGAQDCLVCKA-------GSQIRIP 15831
Query: 290 CIVVGIPPPQVRWYCEGKE-------LENSP-DIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
++ G P P+ W +GK + + P D + A N + I E TG+YS
Sbjct: 15832 AVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSI 15891
Query: 342 FASNIYGTDSTSAEIYIEGV 361
A N G + + + + V
Sbjct: 15892 TAKNKAGQKTANCRVKVMDV 15911
Score = 37.0 bits (84), Expect = 0.13
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + V G + I G P P + W KDG + K+ + D T
Sbjct: 23228 IEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL-KQTTRINVTDSLDLT- 23285
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+L I+ T DD G Y I AN G+ + S ++ P
Sbjct: 23286 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 23323
Score = 37.0 bits (84), Expect = 0.13
Identities = 45/176 (25%), Positives = 76/176 (43%), Gaps = 12/176 (6%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP-LTQRD 1140
++A G ++ G PPP +TW + + + DA + + T SLL P +T+ D
Sbjct: 27281 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYS--IENTDSSSLLTIPQVTRND 27338
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL--ECRVIGM 1198
G Y N G+ + S V+ +V P +KLQ V G L + G
Sbjct: 27339 TGKYILTIENGVGEP----KSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGG 27394
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
P + Y + + T +S +T + LI ++K+ ++ + A+NE GI
Sbjct: 27395 SPIINYVIEKRDATKRTWSVVSHKCSSTSFK--LIDLSEKTPF-FFRVLAENEIGI 27447
Score = 36.6 bits (83), Expect = 0.16
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 3/85 (3%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G P+ + G P PKV W K G R + D L I ++T DD G
Sbjct: 18618 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLV---DTMAFLVIPNSTRDDSG 18674
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y++ NP G + ++ V P
Sbjct: 18675 KYSLTLVNPAGEKAVFVNVRVLDTP 18699
Score = 36.6 bits (83), Expect = 0.16
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G +++ V G P P ++W+ +G+P+ + ++ V ET ++L I + D G Y
Sbjct: 24326 GEDLKIEIPVIGRPRPNISWVKDGEPL--KQTTRVNVEETATSTVLHIKEGNKDDFGKYT 24383
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
ATN G + +L + V+ K
Sbjct: 24384 VTATNSAGTATENLSVIVLEK 24404
Score = 36.6 bits (83), Expect = 0.16
Identities = 33/131 (25%), Positives = 60/131 (45%), Gaps = 16/131 (12%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG----QNSFSLELSVVAKEVKKAPV-----ILEKLQNCGV 1183
++ L ++ ++ A N G + +FS SV+ KE + P I +L C
Sbjct: 28605 VERLVEKTEYEFRVKAKNDAGYSEPREAFS---SVIIKEPQIEPTADLTGITNQLITCKA 28661
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G P ++ + G P P WK + + T +R+S+ T L ++ + + D+G
Sbjct: 28662 --GSPFTIDVPISGRPAPKVTWKLEEMRLKET-DRVSI-TTTKDRTTLTVKDSMRGDSGR 28717
Query: 1244 YTLSAKNEAGI 1254
Y L+ +N AG+
Sbjct: 28718 YFLTLENTAGV 28728
Score = 36.6 bits (83), Expect = 0.16
Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKK-DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G + L+ V G P P W K D E C E++S+ Q T A +I+ +SD+G Y
Sbjct: 29062 GSDLVLDAAVGGKPEPKIIWTKGDKELDLC--EKVSL-QYTGKRATAVIKFCDRSDSGKY 29118
Query: 1245 TLSAKNEAG 1253
TL+ KN +G
Sbjct: 29119 TLTVKNASG 29127
Score = 36.2 bits (82), Expect = 0.21
Identities = 51/221 (23%), Positives = 85/221 (38%), Gaps = 40/221 (18%)
Query: 853 PSMPSQGLAKKN--TKSPQPVNDDNIRETKNAVI-------RDLGKKITFSDV---RPNQ 900
PS PS+ + K+ K PVN + I T N+V D G KI V +
Sbjct: 17097 PSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 17156
Query: 901 QEYKISSFEQRLMNEIEFRL--------------------ERTPVDESDDEIQHDEIPTG 940
+E++ ++ E ++++ E P + + D +
Sbjct: 17157 EEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPP 17216
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
+ I R +H +V G + + I G+P PKV W K+ R+ K R +
Sbjct: 17217 ELILDANMAREQHIKV--GDTLRLSAIIKGVPFPKVTWKKE-----DRDAPTKARIDVTP 17269
Query: 1001 TCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S L I + +D G Y++ NP G + S ++V P
Sbjct: 17270 VGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 17310
Score = 35.8 bits (81), Expect = 0.28
Identities = 20/83 (24%), Positives = 35/83 (42%), Gaps = 1/83 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V G R + G+P P W +G + D H + + L I +RD
Sbjct: 17520 LVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDT 17578
Query: 1142 GTYKCIATNKTGQNSFSLELSVV 1164
G Y+ +N G + ++ L+V+
Sbjct: 17579 GEYQITVSNAAGSKTVAVHLTVL 17601
Score = 35.8 bits (81), Expect = 0.28
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Query: 968 IVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
I+G P+PK W K GK I R + L I+ T D G YTI A NP G
Sbjct: 20403 ILGKPLPKSSWSKAGKDI--RPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Score = 35.8 bits (81), Expect = 0.28
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGH 1187
+ LT+ ++ IA N G S + + + AK+ + P I + V G
Sbjct: 23582 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 23641
Query: 1188 PVRLECRVIGMPPPVFYW-KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G P P W + D E R I ++T A L+++ A + D G Y L
Sbjct: 23642 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEI---KNTDFKALLIVKDAIRIDGGQYIL 23698
Query: 1247 SAKNEAG 1253
A N AG
Sbjct: 23699 RASNVAG 23705
Score = 35.4 bits (80), Expect = 0.36
Identities = 41/162 (25%), Positives = 70/162 (43%), Gaps = 19/162 (11%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV- 1164
W+ G+PV A KM V TG L + Y+ A N+ G + S +
Sbjct: 13634 WVACGEPV---AETKMEV--TG--------LEEGKWYAYRVKALNRQGASKPSRPTEEIQ 13680
Query: 1165 AKEVKKAPVI---LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
A + ++AP I ++ L V G + L V G P P W K + + + RI++
Sbjct: 13681 AVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDK-RITI 13739
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
++ + + I +K+SD G Y + A N G + +++
Sbjct: 13740 -ENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 13780
Score = 35.4 bits (80), Expect = 0.36
Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G I G P+P + W K +++S N + D SL ++ D G
Sbjct: 22555 VHAGESFKVDADIYGKPIPTIQWIKGDQELS--NTARLEIKSTDFATSLSVKDAVRVDSG 22612
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
NY + A N G S + ++ V P
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/94 (21%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
K ++ P + S GQ + E + G P P + W ++G ++ + +
Sbjct: 23224 KDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINV----- 23278
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ ++ TL I E +D G + T +N G
Sbjct: 23279 ---TDSLDLTTLSIKETHKDDGGQYGITVANVVG 23309
Score = 35.4 bits (80), Expect = 0.36
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 6/111 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRD 1140
+V G + +++ ++G P P ++W +G + A +++ T H+LL + +RD
Sbjct: 25799 IVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII--STDNHTLLTVKDCIRRD 25856
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKA-PVILEKL--QNCGVPEGHP 1188
G Y N G S ++ V+ K A P+ + L + C + G P
Sbjct: 25857 TGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRP 25907
Score = 35.4 bits (80), Expect = 0.36
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 4/72 (5%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +G + T I G P P W K+G+ ISKR M + L I+ D G
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKR----AMIATSETHTELVIKEADRGDSG 30203
Query: 1016 NYTIMAANPQGR 1027
Y ++ N G+
Sbjct: 30204 TYDLVLENKCGK 30215
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE-DTGRYSC 341
G+ ++L + +G P P + W+ K L+NS +I I + L + + G+Y
Sbjct: 30643 GSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKV 30702
Query: 342 FASNIYGTDSTSAEIYIE 359
SN++GT ++ I+
Sbjct: 30703 QLSNVFGTVDAILDVEIQ 30720
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 11/99 (11%)
Query: 437 FTKMLQNLSASEGQ-LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
FT+ LQ++ A E + FEC P KV+WY++G + + +R+ S +
Sbjct: 2176 FTQELQDVVAKEKDTMATFECETS-EPFVKVKWYKDGMEVHEGDKYRM-----HSDRKVH 2229
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ L I AED C N V + A+L V G
Sbjct: 2230 FLSILTIDTSDAEDYSCVLVEDEN----VKTTAKLIVEG 2264
Score = 35.0 bits (79), Expect = 0.48
Identities = 40/202 (19%), Positives = 61/202 (30%), Gaps = 6/202 (2%)
Query: 673 EQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQ--VKAPSSQTFSLARPKYFFPST 730
E+ ++ P + PK S ++ PP K+ K P + K P
Sbjct: 10428 EEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEE 10487
Query: 731 NTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPT 790
T P P + + K P V + + P+PP
Sbjct: 10488 PRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPE--APPPKVPEAPKEVVPEKKVPVPPPKK 10545
Query: 791 EPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPS--LPAIPPTNAMGL 848
PP +P + + IP P S V+P +PA PP
Sbjct: 10546 PEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVT 10605
Query: 849 PRSAPSMPSQGLAKKNTKSPQP 870
P P P + + +K P P
Sbjct: 10606 PVKVPEAPKEVVPEKKVPVPPP 10627
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVH-SLLIDPLTQRDA 1141
+A E RL + G P P ++W P+ D ++ V + V+ +L++ + DA
Sbjct: 19993 LAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT--RVSVESSAVNTTLIVYDCQKSDA 20050
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAK 1166
G Y N G ++ + VV K
Sbjct: 20051 GKYTITLKNVAGTKEGTISIKVVGK 20075
Score = 35.0 bits (79), Expect = 0.48
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP---VILEKLQNCGVP 1184
+ ++ L ++ ++ A N G ++ V E + AP + E + V
Sbjct: 20730 ITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVR 20789
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G +R+ + G P P W KDN + + R ++ ++T + L+I + D G +
Sbjct: 20790 AGLSIRIFVPIKGRPAPEVTWTKDNINL---KNRANI-ENTESFTLLIIPECNRYDTGKF 20845
Query: 1245 TLSAKNEAG 1253
++ +N AG
Sbjct: 20846 VMTIENPAG 20854
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/129 (22%), Positives = 47/129 (36%), Gaps = 8/129 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I P++ + D V K + G+ E V G P
Sbjct: 21431 VIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPP 21490
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW ++G +E + I + LV + DSG +T TA+N G
Sbjct: 21491 PTMEWSKDGKELEGTAKLEI--------KIADFSTNLVNKDSTRRDSGAYTLTATNPGGF 21542
Query: 524 VSSIAQLHV 532
I + V
Sbjct: 21543 AKHIFNVKV 21551
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G ++D + G P P + W + G L + + + SL + + D+
Sbjct: 22553 IVVHAGESFKVDADIYGKPIPTIQW-IKGDQELSNTARLEIKSTDFATSLSVKDAVRVDS 22611
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKE-VKKAPVIL 1175
G Y A N G+ S ++ + V+ + + PV++
Sbjct: 22612 GNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI 22646
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +++ + G P PV W KD I R R + T + L ++ + D G
Sbjct: 25801 VKAGEVLKINADIAGRPLPVISWAKDGIEIE-ERARTEI-ISTDNHTLLTVKDCIRRDTG 25858
Query: 1243 WYTLSAKNEAG 1253
Y L+ KN AG
Sbjct: 25859 QYVLTLKNVAG 25869
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 18/106 (16%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIV------------------VGIPPPQVRWYCEGK 307
G+P + ++++++ E + LD + G PPP V W + K
Sbjct: 27251 GEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEK 27310
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
L + I + LTI + DTG+Y N G +S
Sbjct: 27311 NLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSS 27356
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/99 (24%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR- 1139
D++ EG + +P P ++W +G+ V AS ++ ++ + + L P + R
Sbjct: 14395 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV--KASDRLTMKNDHISAHLEVPKSVRA 14452
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVV-----AKEVKKAPV 1173
DAG Y NK G + S+ + V+ K++K + +
Sbjct: 14453 DAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDI 14491
Score = 34.7 bits (78), Expect = 0.62
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 14/144 (9%)
Query: 890 KITFSDVRPNQQEYKIS------SFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCI 943
K FS++ N E+ +S ++E R++ + P + SD D++ K
Sbjct: 21405 KANFSNILEN--EFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIK 21462
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR-REGDGTC 1002
+ K + G + G P P + W KDGK++ K+ + D +
Sbjct: 21463 VDVKFKDTVILKA--GEAFRLEADVSGRPPPTMEWSKDGKELEGT---AKLEIKIADFST 21517
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
+L + +T D G YT+ A NP G
Sbjct: 21518 NLVNKDSTRRDSGAYTLTATNPGG 21541
Score = 34.7 bits (78), Expect = 0.62
Identities = 23/82 (28%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDA 1241
V G +++ + G P P W K ++ + T + +T +A L ++ A + D+
Sbjct: 22555 VHAGESFKVDADIYGKPIPTIQWIKGDQELSNTAR---LEIKSTDFATSLSVKDAVRVDS 22611
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G Y L AKN AG S T + +
Sbjct: 22612 GNYILKAKNVAGERSVTVNVKV 22633
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 2/78 (2%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
K V G PV I G P P WF G ++ + +E + L I TT
Sbjct: 29746 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKL-RESERVTVETH-TKVAKLTIRETTI 29803
Query: 1012 DDDGNYTIMAANPQGRIS 1029
D G YT+ N G S
Sbjct: 29804 RDTGEYTLELKNVTGTTS 29821
Score = 34.3 bits (77), Expect = 0.81
Identities = 67/299 (22%), Positives = 109/299 (36%), Gaps = 33/299 (11%)
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-GTRVQLDCIVVGIP 296
AE +AS G + S + Q FTQ+L+ E T +C P
Sbjct: 2143 AEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFEC-ETSEP 2201
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
+V+WY +G E+ + +H L+I D YSC T+A++
Sbjct: 2202 FVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENV-KTTAKL 2260
Query: 357 YIEGV------SSSDSE-GDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPR 409
+EG D E + E+ I P + + V ++ + R
Sbjct: 2261 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDV--ELKSNGKYTITSRR 2318
Query: 410 VATIQQCQSPTNYLQG-----LDGK----PIIAAPVFTKMLQNLS---ASEGQLVVFECR 457
+ T QG +DGK + P +LQ LS EG +V E +
Sbjct: 2319 GRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVK 2378
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
V S + W ++G ++ S I+ K M L+I ++ ED+G ++ T
Sbjct: 2379 V-SLESVEGVWMKDGQEVQPSDRVHIVIDKQSHM--------LLIEDMTKEDAGNYSFT 2428
Score = 34.3 bits (77), Expect = 0.81
Identities = 28/137 (20%), Positives = 53/137 (38%), Gaps = 9/137 (6%)
Query: 398 VPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECR 457
VP ++ V + R P+ + + K P ++ EG+ +
Sbjct: 14351 VPDKEY-VLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVP 14409
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+ P P V W+++G ++ S R+ K A L + + D+G +T T
Sbjct: 14410 FRAVPVPTVSWHKDGKEVKASD--RLTMKNDHISAH------LEVPKSVRADAGIYTITL 14461
Query: 518 SNKYGTVSSIAQLHVRG 534
NK G+ ++ + V G
Sbjct: 14462 ENKLGSATASINVKVIG 14478
Score = 34.3 bits (77), Expect = 0.81
Identities = 19/82 (23%), Positives = 38/82 (46%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V EG ++ + +P P V W+ +GKE++ S + + L + ++ D G Y
Sbjct: 14398 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Query: 340 SCFASNIYGTDSTSAEIYIEGV 361
+ N G+ + S + + G+
Sbjct: 14458 TITLENKLGSATASINVKVIGL 14479
Score = 34.3 bits (77), Expect = 0.81
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 10/92 (10%)
Query: 268 PPRFTQKLRSR----EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI------HI 317
PP +L R +V G V + V G+P P++ W +E D +
Sbjct: 15394 PPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEV 15453
Query: 318 VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
++ L+I +A ED G Y+ ASN G+
Sbjct: 15454 SRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485
Score = 34.3 bits (77), Expect = 0.81
Identities = 36/153 (23%), Positives = 57/153 (37%), Gaps = 6/153 (3%)
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN--SFSLEL 1161
+ ++L + + + HK+ + L + D Y+ A N GQ SF +
Sbjct: 16749 INYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKP 16808
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
E+ + L+ + G L R G P P W KD + E
Sbjct: 16809 ITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV---LEDDRT 16865
Query: 1222 HQDTTGYACLLIQ-PAKKSDAGWYTLSAKNEAG 1253
H TT L + AK+SD+G Y + +N G
Sbjct: 16866 HIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 16898
Score = 34.3 bits (77), Expect = 0.81
Identities = 21/106 (19%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 428 GKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
G P+I P+ +T++++ + G V + G P+P +EWY++ D +
Sbjct: 26868 GGPVIDLPLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKD--------DKELQTN 26916
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ ++ +++I + +SGC+ N G+ S+ ++ +
Sbjct: 26917 ALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQI 26962
Score = 34.3 bits (77), Expect = 0.81
Identities = 22/65 (33%), Positives = 25/65 (38%), Gaps = 2/65 (3%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
GH V LE G P P W KD +P T L I+ AKK G YT
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 27635
Query: 1246 LSAKN 1250
+ N
Sbjct: 27636 VILDN 27640
Score = 34.3 bits (77), Expect = 0.81
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
AGG P P ++ E L + P + R +E V +G ++L + G P P +W
Sbjct: 30112 AGGPGEPAEVPGTVKVTEML-EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKW 30170
Query: 303 YCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
EG+++ ++ H+ L I EA D+G Y N G + ++ + G
Sbjct: 30171 TKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 30227
Query: 362 SSS 364
+S
Sbjct: 30228 PNS 30230
Score = 34.3 bits (77), Expect = 0.81
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V +G +RL + G P P+ W K+ + I + +M + + L+I+ A + D+G
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDI----SKRAMIATSETHTELVIKEADRGDSG 30203
Query: 1243 WYTLSAKNEAG 1253
Y L +N+ G
Sbjct: 30204 TYDLVLENKCG 30214
Score = 34.3 bits (77), Expect = 0.81
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 5/111 (4%)
Query: 1057 RVQERDKEPL-QERFFRPHFLQAPGDMVAHE---GRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ ER E L Q+ F H + M +H G+ R V P E+ W NG
Sbjct: 32354 KTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVE 32413
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
L ++S +GV +L I D+GTY+ + TN G+ S L V
Sbjct: 32414 -LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDV 32463
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/74 (24%), Positives = 31/74 (41%), Gaps = 1/74 (1%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F + L + V E C + V+WY G+E++ + G++H L
Sbjct: 12822 PTEFVEHLEDQTVTEFDDAVFSC-QLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLI 12880
Query: 328 IAEAFEEDTGRYSC 341
I + +D Y+C
Sbjct: 12881 IKDCRLDDECEYAC 12894
Score = 33.9 bits (76), Expect = 1.1
Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
++D G P + W +GQ L + + + V SL I ++ D GTY+ +N
Sbjct: 25413 KIDVPFKGRPQATVNWRKDGQ-TLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSN 25471
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEKL 1178
G + + + V+ + P+ ++++
Sbjct: 25472 SAGSITVPITIIVLDRPGPPGPIRIDEV 25499
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/63 (28%), Positives = 29/63 (46%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V L+ G P P + W +G L+ S + + N +L+I A +E G+Y+
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 27637
Query: 343 ASN 345
N
Sbjct: 27638 LDN 27640
Score = 33.5 bits (75), Expect = 1.4
Identities = 22/94 (23%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
K+++ L G V F ++G P P +W +G+ I+ + + S+
Sbjct: 17515 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV------- 17567
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L I D+G + T SN G+ + L V
Sbjct: 17568 -LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 17600
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 13/103 (12%)
Query: 428 GKPIIAA-----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
G P+IA P S G+ + E V G P P + W ++G ++
Sbjct: 24300 GVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK------ 24353
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
Q ++ E L I E +D G +T TA+N GT +
Sbjct: 24354 --QTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 24394
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 924 PVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGK 983
P D S DEI A + K V G I G P+P V W KDGK
Sbjct: 24689 PSDSSGAITARDEIDAPN--ASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGK 24746
Query: 984 QISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
++ + +++ T +L ++ D G Y + +N G
Sbjct: 24747 ELEETAARMEIKSTIQKT-TLVVKDCIRTDGGQYILKLSNVGG 24788
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 14/105 (13%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G L+ + G P P++ W +G+ + A+ + +L++ + D
Sbjct: 24717 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 24776
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
G Y +N G K P+ ++ L G PEG
Sbjct: 24777 GQYILKLSNVGG--------------TKSIPITVKVLDRPGPPEG 24807
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G LE + G P P W KD + + T R+ + + T L+++ ++D G
Sbjct: 24719 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGG 24777
Query: 1243 WYTLSAKNEAGIVS 1256
Y L N G S
Sbjct: 24778 QYILKLSNVGGTKS 24791
Score = 33.5 bits (75), Expect = 1.4
Identities = 36/169 (21%), Positives = 67/169 (39%), Gaps = 17/169 (10%)
Query: 873 DDNIRETKNAVIRDLGKKITFSDVRPNQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDE 931
D R NA IR+ + T D++ Q+ +++++ + M+E + +
Sbjct: 29386 DQWYRVHTNATIRNT--EFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEI------EP 29437
Query: 932 IQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEH 991
++ EIP + D K + G+ + + G P P + W K G ++ R
Sbjct: 29438 VERIEIPD----LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR--- 29490
Query: 992 CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ + L ++ D G YTI A N G+ S + + V P
Sbjct: 29491 -AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 29538
Score = 33.1 bits (74), Expect = 1.8
Identities = 27/107 (25%), Positives = 38/107 (35%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
DK L P + +G +V G P PE W NG +
Sbjct: 2067 DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYW 2126
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV 1168
E V L+I +T D+ + A N G+ S L V AK++
Sbjct: 2127 YWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQL 2173
Score = 33.1 bits (74), Expect = 1.8
Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 4/113 (3%)
Query: 917 EFRLERTPVDESDDEIQHDEIPTGKCIA-PIFDKRLKH-FRVTEGSPVTFTCKIVGIPVP 974
EFR++ D ++ +E+ + + P+ D +L V G + + G P P
Sbjct: 18172 EFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFP 18231
Query: 975 KVYWFKDGKQIS-KRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
+V W KD R+ K+ D + + D G Y + A N G
Sbjct: 18232 EVAWTKDKDATDLTRSPRVKIDTRADSS-KFSLTKAKRSDGGKYVVTATNTAG 18283
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 440 MLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT 499
M + ++ G+ + E V G P P +W + + S + + S+
Sbjct: 18904 MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI-------- 18955
Query: 500 LVIAEVFAEDSGCFTCTASNKYGT 523
L+I +V +DSG ++ TA N GT
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENSSGT 18979
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/87 (26%), Positives = 32/87 (36%), Gaps = 8/87 (9%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDG---KQISKRNEHCKMRREGD 999
I P F F V G + +G P P V W KD KQ ++ N +
Sbjct: 22146 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN-----AESTE 22200
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQG 1026
L I+ +D G+Y + N G
Sbjct: 22201 NNSLLTIKDACREDVGHYVVKLTNSAG 22227
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/75 (28%), Positives = 33/75 (44%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V+W + I D+ + +LV+ V DSG +T T
Sbjct: 22966 IKGRPTPEVKWGKVDGEIRDAAIIDV----------TSSFTSLVLDNVNRYDSGKYTLTL 23015
Query: 518 SNKYGTVSSIAQLHV 532
N GT S+ + V
Sbjct: 23016 ENSSGTKSAFVTVRV 23030
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/99 (23%), Positives = 39/99 (39%), Gaps = 5/99 (5%)
Query: 945 PIFDKRLKHFRVTE---GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
P+ D L++ V + G+ V I G P P + W+KD K++ C
Sbjct: 26870 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV--ENTTDL 26927
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S+ I+ + G Y + N G S + + + P
Sbjct: 26928 ASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 26966
Score = 33.1 bits (74), Expect = 1.8
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 15/184 (8%)
Query: 1147 IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWK 1206
+ T KT + + + LS + AP I ++++ VP G R V P W
Sbjct: 32350 LKTQKTSERKYEV-LSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWY 32408
Query: 1207 KDNETIPCTRERISMHQ-DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI-- 1263
+ + +E +H +T+G L I D+G Y N G S A LD+
Sbjct: 32409 HNGVEL---QESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTG 32465
Query: 1264 -----YAQWHHQIPPPMSVRPSGSR---YGSLTSKGLDIFSAFSSMESTMVYSCSSRSVV 1315
YA P SV P +R Y + K A SS+ +R +
Sbjct: 32466 GDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESL 32525
Query: 1316 ESDE 1319
S E
Sbjct: 32526 SSYE 32529
Score = 32.7 bits (73), Expect = 2.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ R+ +V G P P++TW G+ VL L+++ L I + D G Y
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 17981
Query: 1147 IATNKTGQNSFSLELSVV 1164
A N +G S ++V+
Sbjct: 17982 SAKNSSGHAQGSAIVNVL 17999
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVI-----LEKLQNCGVPEG 1186
+ L + ++ A N+ G L+ ++ KE+ + P I + KL V G
Sbjct: 18564 VTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVI--VRAG 18621
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
P+RL V G P P W+K + ++ + DT + L+I + + D+G Y+L
Sbjct: 18622 CPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDL-VDTMAF--LVIPNSTRDDSGKYSL 18678
Query: 1247 SAKNEAG 1253
+ N AG
Sbjct: 18679 TLVNPAG 18685
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 9/81 (11%)
Query: 444 LSASEGQLVVFEC-RVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L+ G +V + G P PK W + G I S +I SM L I
Sbjct: 20388 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSM--------LTI 20439
Query: 503 AEVFAEDSGCFTCTASNKYGT 523
+D+G +T TA+N +GT
Sbjct: 20440 KYATRKDAGEYTITATNPFGT 20460
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 14/127 (11%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++++ V+G P P V W + L+ + ++ L I E D+G Y
Sbjct: 21080 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 21139
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP----AV 398
A NI G I + D G P K +EVSS T + PP V
Sbjct: 21140 ARNIVGEVGDVITIQVH-----DIPGPPTGP-----IKFDEVSSDFVTFSWDPPENDGGV 21189
Query: 399 PQAQHLV 405
P + ++V
Sbjct: 21190 PISNYVV 21196
Score = 32.7 bits (73), Expect = 2.4
Identities = 26/122 (21%), Positives = 46/122 (37%), Gaps = 8/122 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I + T + D + + K + + G+ E V G P
Sbjct: 23595 VIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPL 23654
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW R IE+S I +++ L++ + D G + ASN G+
Sbjct: 23655 PTIEWLRGDKEIEESARCEIKNTDFKAL--------LIVKDAIRIDGGQYILRASNVAGS 23706
Query: 524 VS 525
S
Sbjct: 23707 KS 23708
Score = 32.7 bits (73), Expect = 2.4
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 10/131 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVI---LEKLQNCGVPEGHP 1188
I LT ++ + NK G + S +AKE ++ P+ E + V G
Sbjct: 26144 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 26203
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTT-GYACLLIQPAKKSDAGWYTLS 1247
+ G P P W K P T R + DTT L I+ A ++D+G YTL+
Sbjct: 26204 FTMTVPFRGRPVPNVLWSK-----PDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLT 26258
Query: 1248 AKNEAGIVSCT 1258
+N S T
Sbjct: 26259 IQNVLSAASLT 26269
Score = 32.7 bits (73), Expect = 2.4
Identities = 28/151 (18%), Positives = 56/151 (37%), Gaps = 8/151 (5%)
Query: 383 EVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
+VS T + P ++A+ V TI + + D +
Sbjct: 27907 DVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFD 27966
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L G+ + + V+G P P+V W+++G IE + I + +L +
Sbjct: 27967 GLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST--------SLFV 28018
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ + G +T A N G+ + ++ V+
Sbjct: 28019 RDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 28049
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/94 (25%), Positives = 38/94 (40%), Gaps = 10/94 (10%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ + +G ++ +KG P P +W +EG I K +A E LV
Sbjct: 30144 EGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI----------SKRAMIATSETHTELV 30193
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGN 535
I E DSG + NK G + ++ V G+
Sbjct: 30194 IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 30227
Score = 32.3 bits (72), Expect = 3.1
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 5/81 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G RL + G+P P++TW + DA K + T V S L I D G Y
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAHEDGGIYS 17288
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
N G + S+++ V+ K
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDK 17309
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCE--GKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V G ++L+ V G P P+V W + +L SP + I + ++ +A D G
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 18272
Query: 338 RYSCFASNIYGT 349
+Y A+N G+
Sbjct: 18273 KYVVTATNTAGS 18284
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 7/77 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+ V E ++G P P V W ++G +E++ + + TLV+ +
Sbjct: 24722 GETFVLEADIRGKPIPDVVWSKDGKELEET-------AARMEIKSTIQKTTLVVKDCIRT 24774
Query: 509 DSGCFTCTASNKYGTVS 525
D G + SN GT S
Sbjct: 24775 DGGQYILKLSNVGGTKS 24791
Score = 32.3 bits (72), Expect = 3.1
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 9/120 (7%)
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA-HEGRLCRLDCKVSGLPPPELT 1105
S G G ++ P E R H GD+V G LD V G P P++
Sbjct: 29026 SKGSESTGPVTCRDEYAPPKAELDARLH-----GDLVTIRAGSDLVLDAAVGGKPEPKII 29080
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR-DAGTYKCIATNKTGQNSFSLELSVV 1164
W + + D K+ ++ TG + + R D+G Y N +G + S+ + V+
Sbjct: 29081 WTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVL 29138
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
++ L + V E +C V P + W +GK L + +I G+ L IA
Sbjct: 2623 SKPLTDQTVAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAAT 2681
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
+D G Y+ + T TSA++ +E V
Sbjct: 2682 KLDDIGEYTYKVA----TSKTSAKLKVEAV 2707
Score = 32.0 bits (71), Expect = 4.0
Identities = 61/283 (21%), Positives = 99/283 (34%), Gaps = 48/283 (16%)
Query: 635 QATKTPEPSSPV----KEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPF 690
+ K PE PV KE PP P++ + + +V + + PP+ E P
Sbjct: 9980 EVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPE--EKVPVPVPKKVEAPPAKVPEVPK 10037
Query: 691 SMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAAT----------VAPS 740
PA K+V+AP ++ + PK P V
Sbjct: 10038 KPVPEKKVPVPA----PKKVEAPPAKVPEV--PKKLIPEEKKPTPVPKKVEAPPPKVPKK 10091
Query: 741 SSPVFTLSSTPQTIQ-----RTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPG----PTE 791
PV + PQ + V +E +L V + L + E LP P E
Sbjct: 10092 REPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEE 10151
Query: 792 PTPPPFTFSIPSGNQFQP--------RCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPT 843
PP +P +F P + P+P +P I+ V V+P PP
Sbjct: 10152 EEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVP-APVPEIKKKVTEKKVVIPKKEEAPPA 10210
Query: 844 NAMGLPRSAPS----MPSQG--LAKKNTKSP--QPVNDDNIRE 878
+P+ +P + L + T+ P +P++++ I E
Sbjct: 10211 KVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPE 10253
Score = 32.0 bits (71), Expect = 4.0
Identities = 27/131 (20%), Positives = 52/131 (39%), Gaps = 10/131 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCI 291
EA+RR+ + GG+ P +P + + P +F ++++ + E V I
Sbjct: 11085 EAERRKLRPGS----GGEKPPDEAPFTYQLK---AVPLKFVKEIKDIILTESEFVGSSAI 11137
Query: 292 VVGIPPPQVR---WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ P W +G + SP + G L I + D G Y+C
Sbjct: 11138 FECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNK 11197
Query: 349 TDSTSAEIYIE 359
+++A++ +E
Sbjct: 11198 EKTSTAKLVVE 11208
Score = 32.0 bits (71), Expect = 4.0
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
RL + G P PE+ W + +L D + + + L+ID +T+ D+G Y N
Sbjct: 25126 RLFVTIKGRPEPEVKWE-KAEGILTDRAQIEVT--SSFTMLVIDNVTRFDSGRYNLTLEN 25182
Query: 1151 KTGQ----------NSFSLELSVVAKEVKKAPVIL 1175
+G +S S +++ +EVKK V L
Sbjct: 25183 NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTL 25217
Score = 32.0 bits (71), Expect = 4.0
Identities = 42/197 (21%), Positives = 71/197 (36%), Gaps = 33/197 (16%)
Query: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
KIVG + K +Q ++R C + C + + D + I+A N G
Sbjct: 27885 KIVGYSIEK-------RQGNERWVRCNFTDVSE--CQYTVTGLSPGDRYEFRIIARNAVG 27935
Query: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
IS P +S G ++ + P+ E F P + ++
Sbjct: 27936 TISP---------PSQSS---------GIIMTRDENVPPIVE--FGPEYFDG---LIIKS 27972
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G R+ V G P P +TW +G + + + G SL + T+ G Y
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDGVEI-EKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 28031
Query: 1147 IATNKTGQNSFSLELSV 1163
A N +G +++ V
Sbjct: 28032 EAKNASGSAKAEIKVKV 28048
Score = 32.0 bits (71), Expect = 4.0
Identities = 18/75 (24%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
+D +SG P P++TW L + L + + +L + + D+G Y N
Sbjct: 28667 IDVPISGRPAPKVTWKLE-EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 28725
Query: 1152 TGQNSFSLELSVVAK 1166
G +FS+ + V+ +
Sbjct: 28726 AGVKTFSVTVVVIGR 28740
Score = 31.6 bits (70), Expect = 5.3
Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 8/90 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE-EICTLVI 502
L+ G + E V+G P P+V W ++ +D+ D L + PR + + +
Sbjct: 18211 LTVKAGDTIRLEAGVRGKPFPEVAWTKD----KDATD---LTRSPRVKIDTRADSSKFSL 18263
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ D G + TA+N G+ + A ++V
Sbjct: 18264 TKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V W ++ I K ++ E L+I E D+G F T
Sbjct: 20800 IKGRPAPEVTWTKDN----------INLKNRANIENTESFTLLIIPECNRYDTGKFVMTI 20849
Query: 518 SNKYGTVSSIAQLHV 532
N G S + V
Sbjct: 20850 ENPAGKKSGFVNVRV 20864
Score = 31.6 bits (70), Expect = 5.3
Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 10/101 (9%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P P+V+W + ++ D + LVI V DSG + T
Sbjct: 25131 IKGRPEPEVKWEKAEGILTDRAQIEV----------TSSFTMLVIDNVTRFDSGRYNLTL 25180
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEP 558
N G+ ++ + V + N ++ + + EP
Sbjct: 25181 ENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 25221
Score = 31.6 bits (70), Expect = 5.3
Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 13/97 (13%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
KP + P T N+ A E QL + + KG P V W ++G ++++ + K
Sbjct: 25394 KPSVELPFHTF---NVKARE-QLKI-DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSK- 25447
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ +L I E ED G + SN G+++
Sbjct: 25448 -------TVTSLSIKEASKEDVGTYELCVSNSAGSIT 25477
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 8/81 (9%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
Q ++ G + + G P+PKV W E ++++ I K R+ TL
Sbjct: 28655 QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRT--------TLT 28706
Query: 502 IAEVFAEDSGCFTCTASNKYG 522
+ + DSG + T N G
Sbjct: 28707 VKDSMRGDSGRYFLTLENTAG 28727
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP T I G P PKV W + ++ K + + D T +L ++ + D G Y
Sbjct: 28662 GSPFTIDVPISGRPAPKVTWKLEEMRL-KETDRVSITTTKDRT-TLTVKDSMRGDSGRYF 28719
Query: 1019 IMAANPQG 1026
+ N G
Sbjct: 28720 LTLENTAG 28727
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++L V G PPP + W +G +L + I ++ +L L + + D G+Y+
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--LIVDKVNRYDAGKYTIE 29518
Query: 343 ASNIYGTDSTSAEIYI 358
A N G S + + +
Sbjct: 29519 AENQSGKKSATVLVKV 29534
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/90 (24%), Positives = 39/90 (43%), Gaps = 7/90 (7%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQP--VLPDASHKM---LVRETGVHS--LLID 1134
+V G R+ + G P P+ +W +G+ + D H + ET +S ++I
Sbjct: 15820 LVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIP 15879
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
+ G Y A NK GQ + + + V+
Sbjct: 15880 ECKRSHTGKYSITAKNKAGQKTANCRVKVM 15909
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G + ++ G P P + W K+GK + R + + ++ L I+ D G
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLP-RVELQIKEAVRADHG 17977
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y I A N G S + V P
Sbjct: 17978 KYIISAKNSSGHAQGSAIVNVLDRP 18002
Score = 31.2 bits (69), Expect = 6.9
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 1162 SVVAKEVKKAP-VILEKLQNCG--VPEGHPVRLEC-RVIGMPPPVFYWKKDNETIPCTRE 1217
+++ K+ +AP ++L+ G + G + L ++G P P W K + I
Sbjct: 20366 TIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI--RPS 20423
Query: 1218 RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
I+ T + L I+ A + DAG YT++A N G
Sbjct: 20424 DITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 6/90 (6%)
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+RL + G P P W+K E I R +I + T+ + L+I + D+G Y L+
Sbjct: 25125 LRLFVTIKGRPEPEVKWEKA-EGILTDRAQIEV---TSSFTMLVIDNVTRFDSGRYNLTL 25180
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
+N +G S TA +++ P +++R
Sbjct: 25181 ENNSG--SKTAFVNVRVLDSPSAPVNLTIR 25208
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/84 (26%), Positives = 33/84 (39%), Gaps = 6/84 (7%)
Query: 1076 LQAPGDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS---- 1130
L GD + G + V+GLP P++ W N + + +E S
Sbjct: 15401 LSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT 15460
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTG 1153
L I + D GTY A+N+ G
Sbjct: 15461 ELSIPKAVREDKGTYTVTASNRLG 15484
Score = 30.8 bits (68), Expect = 9.0
Identities = 20/69 (28%), Positives = 27/69 (39%), Gaps = 4/69 (5%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDDDGNY 1017
G T + G P PKV WFKD + + + H K T +L D G Y
Sbjct: 16833 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTT---PATLALEKIKAKRSDSGKY 16889
Query: 1018 TIMAANPQG 1026
++ N G
Sbjct: 16890 CVVVENSTG 16898
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/79 (21%), Positives = 32/79 (40%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
E + +L + G P P V W L + + + +L + + + D G+Y+
Sbjct: 19996 ENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTI 20055
Query: 342 FASNIYGTDSTSAEIYIEG 360
N+ GT + I + G
Sbjct: 20056 TLKNVAGTKEGTISIKVVG 20074
Score = 30.8 bits (68), Expect = 9.0
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYKCIATNKTGQ 1154
+ G P P+ +W G+ + P S + T S+L I T++DAG Y ATN G
Sbjct: 20403 ILGKPLPKSSWSKAGKDIRP--SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGT 20460
Query: 1155 NSFSLELSVVAKEVKKAPV 1173
++++V+ PV
Sbjct: 20461 KVEHVKVTVLDVPGPPGPV 20479
Score = 30.8 bits (68), Expect = 9.0
Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 12/76 (15%)
Query: 458 VKGAPSPKVEWYRE-GTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
+KG P+P+V+W R+ G ++ + S+ L++ V DSG + T
Sbjct: 21884 IKGRPAPEVKWARDHGESLDKA-----------SIESTSSYTLLIVGNVNRFDSGKYILT 21932
Query: 517 ASNKYGTVSSIAQLHV 532
N G+ S+ + V
Sbjct: 21933 VENSSGSKSAFVNVRV 21948
Score = 30.8 bits (68), Expect = 9.0
Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 8/88 (9%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE---GDGTCSLHIESTTSD 1012
V G + I G P+P + W KDG +I +R R E D L ++
Sbjct: 25801 VKAGEVLKINADIAGRPLPVISWAKDGIEIEER-----ARTEIISTDNHTLLTVKDCIRR 25855
Query: 1013 DDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y + N G S + + V P
Sbjct: 25856 DTGQYVLTLKNVAGTRSVAVNCKVLDKP 25883
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/77 (22%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+++ + G P P + W ++G IE+ I+ ++ L + +
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTL--------LTVKDCIRR 25855
Query: 509 DSGCFTCTASNKYGTVS 525
D+G + T N GT S
Sbjct: 25856 DTGQYVLTLKNVAGTRS 25872
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAGNLHSLTIAEAFEEDTGR 338
V G+ +++D + G P P+V +G L+ + + + A NL ++ + E+ D GR
Sbjct: 26488 VRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL-TINLKESVTADAGR 26546
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y A+N GT I +
Sbjct: 26547 YEITAANSSGTTKAFINIVV 26566
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 970 GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRIS 1029
G P P + W KDG + K +E + + + +L I++ + G YT++ N RI+
Sbjct: 27589 GKPKPSISWLKDGLPL-KESEFVRFSKT-ENKITLSIKNAKKEHGGKYTVILDNAVCRIA 27646
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 223 bits (568), Expect = 9e-58
Identities = 144/450 (32%), Positives = 227/450 (50%), Gaps = 47/450 (10%)
Query: 878 ETKNAVIRD-LGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD- 935
E + A+IR + K QE+ ISSFE+RL+ EIE+R+ +T ++E +E +
Sbjct: 1173 EKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEK 1232
Query: 936 ---EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
+I + + FD R+K++R+ EG VTF CK+ G P+PK+ W+KDGK+I K E
Sbjct: 1233 MAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRI-KHGERY 1291
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL------------- 1039
+M DG SL I +D+G YT A+N +G CSG L V+
Sbjct: 1292 QMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLE 1351
Query: 1040 ----------------PIR--------SRLTSAGQSHRGRS---RVQERDKEPLQERFFR 1072
PIR +R++ A S S R++E D+ L ER ++
Sbjct: 1352 PVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL-ERLYK 1410
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F+ P EG+ R D KV G P PE W +GQ ++ D +HK++++E G SL+
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I P T D+G + +A N+ G++S S+ L+V A E + P+ +EKL+N + EG + ++
Sbjct: 1471 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1530
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
R G P P W K+++ I + + T G A L I D+ WYT +A N+A
Sbjct: 1531 VRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKA 1590
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS 1282
G + ++++ ++ P + P G+
Sbjct: 1591 GRDTTRCKVNVEVEFAEPEPERKLIIPRGT 1620
Score = 111 bits (277), Expect = 5e-24
Identities = 91/322 (28%), Positives = 141/322 (43%), Gaps = 17/322 (5%)
Query: 950 RLKHFRVTEGSPVTFTCKIVGIPVP-KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
++ H EG V + CKI +V W+ +Q+ + +E ++ E DG L+++
Sbjct: 25268 QIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQL-ENSEKYEITYE-DGVAILYVKD 25325
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER-DKEPLQ 1067
T DDG Y N G S L V+ + R R +++ R D L
Sbjct: 25326 ITKLDDGTYRCKVVNDYGEDSSYAELFVKGV----REVYDYYCRRTMKKIKRRTDTMRLL 25381
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET- 1126
ER P F + A+ G R ++ P P +TW +GQ + P + K E+
Sbjct: 25382 ER--PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 25439
Query: 1127 -GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNC 1181
G++ L I+ +T D Y +A NK G++S +L+V + P+ L N
Sbjct: 25440 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 25499
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
EG V E RV G+PPP W+KD + + +H+ YA L I+ D
Sbjct: 25500 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYA-LHIRDTLPEDT 25558
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G+Y ++A N AG SC A L +
Sbjct: 25559 GYYRVTATNTAGSTSCQAHLQV 25580
Score = 107 bits (267), Expect = 8e-23
Identities = 229/1099 (20%), Positives = 382/1099 (34%), Gaps = 191/1099 (17%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T+ +++ EVPE +C V P + W G E+E S IV G LH L I
Sbjct: 2839 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNT 2897
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
ED+ Y+ + G D SA + + + + D N EE + I V+ +
Sbjct: 2898 STEDSAEYTF----VCGNDQVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISY 2953
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-------LDGKPIIAAPV-------- 436
+ V Q R + + N G + GK A +
Sbjct: 2954 KWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIE 3013
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
F K ++++ E + +FEC V P V+W ++ ++ + +I ++K
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECEVS-EPDITVQWMKDDQELQITDRIKIQKEK--------Y 3064
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+ L+I D+G +T A T A+L V G + + + + I
Sbjct: 3065 VHRLLIPSTRMSDAGKYTVVAGGNVST----AKLFVEGRD-------VRIRSIKKEVQVI 3113
Query: 557 EPQPSPPHSEPPSVEQPPKPKLEGVLVNHN-EPRSSSRIGLRVHFNLPEDDKGSEASSEA 615
E Q + E + +G+ +N + R + R+H + + S+A
Sbjct: 3114 EKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYT 3173
Query: 616 GVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAK----------------PKLD 659
V ++ + PEP ++E PV + PK+
Sbjct: 3174 FVAGRNRSSVTLY--------VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKIS 3225
Query: 660 STQLQQLHNQVLLEQ--HQLQNPPPSSPKEFPFSMTVLNSNAPP----AVTTSSKQVKAP 713
+ +QL + + H Q + FP V A A T++S V+ P
Sbjct: 3226 WYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVP 3285
Query: 714 SSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTK 773
+ P Y A + P V T P Q VS L VS S K
Sbjct: 3286 EVVSPDQEMPVY-------PPAIITPLQDTV-TSEGQPARFQCRVSGTDLKVSWYSKDKK 3337
Query: 774 SPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSV 833
P F + +Q P + F++S
Sbjct: 3338 IK------------------PSRFFRMTQFEDTYQLEIAEAYPED-----EGTYTFVAS- 3373
Query: 834 LPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITF 893
++ + T + L A S G + + Q V D + + ++ + + K+I
Sbjct: 3374 -NAVGQVSSTANLSLEVQALDRQSSGKDVRESAKSQAVADSSFTKEESKISQ---KEI-- 3427
Query: 894 SDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD-----------------E 936
+ + EY++ FE + I T D ++ H +
Sbjct: 3428 KSFQGSSYEYEVQVFESVSQSSIH-----TAASVQDTQLCHTASLSQIAESTELSKECAK 3482
Query: 937 IPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRR 996
TG+ AP L+ V G F C + V W +G +I + +E K +
Sbjct: 3483 ESTGE--APKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEE-SERLKQSQ 3539
Query: 997 EGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP---------------- 1040
G+ L I + D G Y+ + N G + S L V+ P
Sbjct: 3540 NGN-IQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGAPESILHERIEQEIEMEM 3598
Query: 1041 --IRSRLTSAGQS--HRGR---SRVQER----DKEPLQERFFR-------PHFLQAPGDM 1082
S SA + H S++ E + P+ F P F++ +
Sbjct: 3599 KEFSSSFLSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNA 3658
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAG 1142
G + L V G+P P++ W NG + P A +K V + HSL+I D G
Sbjct: 3659 DISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKF-VFDGDDHSLIILFTKLEDEG 3717
Query: 1143 TYKCIATNKTGQNSFSLEL---------------SVVAKEVKKA-----PVILEKLQNCG 1182
Y C+A+N G+ S L S VAK ++K P L++L+
Sbjct: 3718 EYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIR 3777
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
+G P E V+G P P W K+N+ + CT ++ + G ++ ++ D+G
Sbjct: 3778 CAQGLPAIFEYTVVGEPAPTVTWFKENKQL-CTSVYYTIIHNPNGSGTFIVNDPQREDSG 3836
Query: 1243 WYTLSAKNEAGIVSCTARL 1261
Y A+N G +C A L
Sbjct: 3837 LYICKAENMLGESTCAAEL 3855
Score = 105 bits (262), Expect = 3e-22
Identities = 78/264 (29%), Positives = 111/264 (42%), Gaps = 35/264 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L++ V EG V L+C + G P P V WY E ++E+S D I + L
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 955
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I EAF ED+GR++C A N GT STS + ++ + E
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE-------------------- 995
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKP-IIAAPVFTKMLQNLSA 446
T+AV + + V V + G P I PV K++
Sbjct: 996 --TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV----- 1048
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG VVF C+V G P P V W + G + +++ K C LVI+ F
Sbjct: 1049 -EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGE------CKLVISMTF 1101
Query: 507 AEDSGCFTCTASNKYGTVSSIAQL 530
A+D+G +T NK+G S+ A L
Sbjct: 1102 ADDAGEYTIVVRNKHGETSASASL 1125
Score = 98.6 bits (244), Expect = 4e-20
Identities = 96/360 (26%), Positives = 139/360 (38%), Gaps = 77/360 (21%)
Query: 173 IRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQE 232
+R R+ K +E Q V++ + D+ + + I R V +E++
Sbjct: 3101 VRIRSIKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYV---VERRI 3156
Query: 233 AKRREAEQAASEAAGGDTTPGSSPSS--LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+ +E S+A G + SS LY P +PP+ Q+L+ V G +
Sbjct: 3157 HRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAP--EPPQVLQELQPVTVQSGKPARFCA 3214
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
++ G P P++ WY E + L + G ++L + EAF ED Y+C A N YG
Sbjct: 3215 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVA 3274
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRV 410
+TSA + +E EV SP V PPA+
Sbjct: 3275 TTSASLSVE---------------------VPEVVSPDQEMPVYPPAI------------ 3301
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYR 470
LQ+ SEGQ F+CRV G KV WY
Sbjct: 3302 ---------------------------ITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYS 3333
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+ I+ S FR M + E+ L IAE + ED G +T ASN G VSS A L
Sbjct: 3334 KDKKIKPSRFFR--------MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3385
Score = 98.6 bits (244), Expect = 4e-20
Identities = 106/432 (24%), Positives = 171/432 (39%), Gaps = 60/432 (13%)
Query: 151 LNKAADFIEELSSLFKSHSSKRIRPRACKN---HKSKLESQNKVMQENSSSFSDLSERRE 207
++ A+ E+ +L + S K +R A S + ++K+ Q+ SF S E
Sbjct: 3379 VSSTANLSLEVQALDRQSSGKDVRESAKSQAVADSSFTKEESKISQKEIKSFQGSSYEYE 3438
Query: 208 R------SSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYY 261
S I A +D ++ H + E+ + + E A
Sbjct: 3439 VQVFESVSQSSIHTAASVQDTQLCHTASLSQIA--ESTELSKECA--------------- 3481
Query: 262 EEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG 321
+E G+ P+ L+ V G Q C++ V W EG ++E S + Q G
Sbjct: 3482 KESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESERLKQSQNG 3541
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP 381
N+ LTI D G YSC N G +TSA + +EG P RI++
Sbjct: 3542 NIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEGA--------PESILHERIEQE 3593
Query: 382 NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQ-----CQSPTNYLQGLDGKPIIAAPV 436
E+ +S+ + A + H A+ +++ I + +SP Y D + P+
Sbjct: 3594 IEMEMKEFSSSFL-SAEEEGLH-SAELQLSKINETLELLSESPV-YPTKFDSEKEGTGPI 3650
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
F K + N S G + V G P PK++W+ G L+ S D++ + +
Sbjct: 3651 FIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFV--------FDGD 3702
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV----RGNEDLSNNGSLHSANSTTN 552
+L+I ED G +TC ASN YG A L + G++D ++ A S
Sbjct: 3703 DHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAV--AKSLEK 3760
Query: 553 LAAIEPQPSPPH 564
L P PPH
Sbjct: 3761 LGG----PCPPH 3768
Score = 98.2 bits (243), Expect = 5e-20
Identities = 131/585 (22%), Positives = 217/585 (37%), Gaps = 90/585 (15%)
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
+ E H+ E Q +K E + SE+ T + E G P F +++ + ++
Sbjct: 3609 EEEGLHSAELQLSKINETLELLSESPVYPTK--------FDSEKEGTGPIFIKEVSNADI 3660
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
G L V+GIP P+++W+ G L S D V G+ HSL I ED G Y+
Sbjct: 3661 SMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYT 3720
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C ASN YG SA + I +S EG + E + + K E P
Sbjct: 3721 CMASNDYGKTICSAYLKI----NSKGEGHKDTETESAVAKSLEKLGGP------------ 3764
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
P F K L+ + ++G +FE V G
Sbjct: 3765 --------------------------------CPPHFLKELKPIRCAQGLPAIFEYTVVG 3792
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P+P V W++E + S + I+ P T ++ + EDSG + C A N
Sbjct: 3793 EPAPTVTWFKENKQLCTSVYYTIIH-------NPNGSGTFIVNDPQREDSGLYICKAENM 3845
Query: 521 YGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEG 580
G + A+L V ED + A ST A E P P + P+VE +
Sbjct: 3846 LGESTCAAELLVL-LEDTDMTDTPCKAKSTPE--APEDFPQTP-LKGPAVEALDSEQEIA 3901
Query: 581 VLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSE--------AGVVTTRQTRPDSFQE-- 630
V +++ + K +E SS+ ++ + P+S +E
Sbjct: 3902 TFVKDTILKAALITEENQQLSYEHIAKANELSSQLPLGAQELQSILEQDKLTPESTREFL 3961
Query: 631 RFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPF 690
NG P+KEP P L + S + ++ E+ + Q + K FP
Sbjct: 3962 CINGSI-----HFQPLKEPSPNLQLQIVQSQKTFSKEGILMPEEPETQAVLSDTEKIFPS 4016
Query: 691 SMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSST 750
+M++ N+ + + + S P T+ ++P V +
Sbjct: 4017 AMSIEQINSLTVEPLKTLLAEPEGNYPQSSIEPPMHSYLTSVAEEVLSPKEKTVSDTNRE 4076
Query: 751 PQ-TIQRTVSKESLLVSH-------PSVQTKSPGGLSIQNEPLPP 787
+ T+Q+ ++ +L++S S+Q+ + EPL P
Sbjct: 4077 QRVTLQKQEAQSALILSQSLAEGHVESLQSPDVMISQVNYEPLVP 4121
Score = 94.0 bits (232), Expect = 9e-19
Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 37/255 (14%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + L+ V EGS TF I G PVP+V WF+DG+ IS DG
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + T + G Y++ A N G+ + + L+V++ +
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-----------------------ET 101
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
P P+F+Q M +G RL +V+G+P P + + +G + + +
Sbjct: 102 AP-------PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQ-IS 153
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE---VKKAPVILEKLQN 1180
+E ++SLLI D+GTY ATN G+ + + EL V +E KK I+ Q
Sbjct: 154 QEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ- 212
Query: 1181 CGVPEGHPVRLECRV 1195
+ E R+E ++
Sbjct: 213 --ISESRQTRIEKKI 225
Score = 91.7 bits (226), Expect = 4e-18
Identities = 58/165 (35%), Positives = 88/165 (53%), Gaps = 12/165 (7%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F Q+L+S V +G++V+L V GIP P V++Y +G E+++S D I Q G+L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL 162
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG--------VSSSDSEGDPNKEEMNRIQ 379
IAEA+ ED+G YS A+N G +++AE+ ++G + S ++ RI+
Sbjct: 163 IAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIE 222
Query: 380 KPNE----VSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
K E S T VI A Q PR+ + +SPT
Sbjct: 223 KKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSPT 267
Score = 90.5 bits (223), Expect = 1e-17
Identities = 91/376 (24%), Positives = 143/376 (38%), Gaps = 70/376 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V EG F+C G PVP V W + G+ +S H + T I S + D+G
Sbjct: 26267 VYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKST--FEISSVQASDEG 26324
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG---QSHRGRSRVQERDKEPLQERFFR 1072
NY+++ N +G+ L +Q + + ++ +S R + E K P + +
Sbjct: 26325 NYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPE 26384
Query: 1073 PHFLQA---------PGDMVAH-----------------EGRLCRLDCKV--SGLPPPEL 1104
P +A P + V H + +L C V S L E+
Sbjct: 26385 PSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEV 26444
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL----- 1159
TW +G+ + + + G + L I+ LT+ D G Y C + + G + +L
Sbjct: 26445 TWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQ 26504
Query: 1160 -----------------------ELSVVAKEVKKA-------PVILEKLQNCGVPEGHPV 1189
E +V K KA PVI+ LQ+ V
Sbjct: 26505 AFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVA 26564
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+ + G P P W KD + I + + +D G+ L I SD+G YT + K
Sbjct: 26565 KFAVKATGEPRPTAIWTKDGKAI-TQGGKYKLSEDKGGF-FLEIHKTDTSDSGLYTCTVK 26622
Query: 1250 NEAGIVSCTARLDIYA 1265
N AG VS + +L I A
Sbjct: 26623 NSAGSVSSSCKLTIKA 26638
Score = 89.4 bits (220), Expect = 2e-17
Identities = 70/308 (22%), Positives = 131/308 (42%), Gaps = 43/308 (13%)
Query: 259 LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV 318
L + L P F + RS+ + EG V C + G P P++ W+ + S ++ I
Sbjct: 26819 LTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSIS 26878
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI---------------EGVSS 363
++ N++SL I A D+G+Y+ A N G S +A + + G +S
Sbjct: 26879 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTS 26938
Query: 364 SDSEGDPNKEEMNRIQKPNEVSSPPTTSA----VIPPAVPQAQHLVAQPR---------- 409
+M+ ++ SS ++SA + A AQ + +
Sbjct: 26939 LQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSF 26998
Query: 410 --VATIQQCQSPTNYL--QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
++ + Q +S T+ + G+ G P P + ++S EG+++ C G P+P+
Sbjct: 26999 MGISNMTQLESSTSKMLKAGIRGIP----PKIEALPSDISIDEGKVLTVACAFTGEPTPE 27054
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
V W G I R + +++ TL+I +V +D G +T + N++G+ S
Sbjct: 27055 VTWSCGGRKIHSQEQGRF------HIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 27108
Query: 526 SIAQLHVR 533
+ +H+R
Sbjct: 27109 ATVNIHIR 27116
Score = 89.0 bits (219), Expect = 3e-17
Identities = 101/388 (26%), Positives = 143/388 (36%), Gaps = 79/388 (20%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F K +K +V E F C+ V P V W KD +++ + + K+++E L I
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECE-VSEPDITVQWMKDDQEL-QITDRIKIQKE-KYVHRLLI 3070
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR--------- 1057
ST D G YT++A G +S + L V+ +R R + R
Sbjct: 3071 PSTRMSDAGKYTVVAG---GNVS-TAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNE 3126
Query: 1058 -----------------VQERDKEPLQERFFR---------------------------- 1072
VQER K ++ R R
Sbjct: 3127 DDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLY 3186
Query: 1073 ------PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P LQ + G+ R +SG P P+++W Q + K L +
Sbjct: 3187 VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL-HDG 3245
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA--------PVILEKL 1178
++LL+ DA Y C A N G + S LSV EV P I+ L
Sbjct: 3246 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3305
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ EG P R +CRV G V ++ KD + P R++ +DT L I A
Sbjct: 3306 QDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ---LEIAEAYP 3362
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
D G YT A N G VS TA L + Q
Sbjct: 3363 EDEGTYTFVASNAVGQVSSTANLSLEVQ 3390
Score = 87.8 bits (216), Expect = 6e-17
Identities = 61/246 (24%), Positives = 113/246 (45%), Gaps = 14/246 (5%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
PIF K + + ++ G T + ++GIP PK+ WF +G ++ ++ K +GD SL
Sbjct: 3649 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADY-KFVFDGDDH-SL 3706
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T +D+G YT MA+N G+ CS +L ++ S G+ H+ + + +
Sbjct: 3707 IILFTKLEDEGEYTCMASNDYGKTICSAYL---------KINSKGEGHKD-TETESAVAK 3756
Query: 1065 PLQERF--FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
L++ PHFL+ + +G + V G P P +TW + + + ++
Sbjct: 3757 SLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTII 3816
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
G + +++ + D+G Y C A N G+++ + EL V+ ++ +
Sbjct: 3817 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTPE 3876
Query: 1183 VPEGHP 1188
PE P
Sbjct: 3877 APEDFP 3882
Score = 87.8 bits (216), Expect = 6e-17
Identities = 63/213 (29%), Positives = 86/213 (40%), Gaps = 25/213 (11%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GTCSLHIESTTSDDDGNY 1017
G V F I P P V W+K G++I + K E D G L I S T+DDD Y
Sbjct: 25399 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 25458
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
T++A N G SC L V P P + RP F +
Sbjct: 25459 TVVARNKYGEDSCKAKLTVTLHP------------------------PPTDSTLRPMFKR 25494
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
+ EG+ + +VSG+PPP L W +GQP+ + +++ ++L I
Sbjct: 25495 LLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTL 25554
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK 1170
D G Y+ ATN G S L V KK
Sbjct: 25555 PEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 25587
Score = 86.7 bits (213), Expect = 1e-16
Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 9/202 (4%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR-ETGVHSL 1131
P F Q +V EG + +SG P PE++W +GQ + + + G L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I +T+ ++G Y ATN +GQ + + EL V A+ P +++LQ+ V +G VRL
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAP--PNFVQRLQSMTVRQGSQVRL 123
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ RV G+P PV + +D I + + +IS D LLI A D+G Y+++A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYS---LLIAEAYPEDSGTYSVNATN 180
Query: 1251 EAGIVSCTARLDIYAQWHHQIP 1272
G + TA ++ Q ++P
Sbjct: 181 SVGRATSTA--ELLVQGEEEVP 200
Score = 86.3 bits (212), Expect = 2e-16
Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 21/273 (7%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--DIHIVQAGNLHSLTI 328
F ++++ + EG V C + G P P++ WY +GK +++ + +Q G SL I
Sbjct: 1247 FDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRA-SLRI 1305
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEG-DPNKEEMNRIQ--KPNEVS 385
ED G Y+ FASNI G S ++Y+E + + P E ++RI+ P VS
Sbjct: 1306 PVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1365
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI--IAAPVFTKMLQN 443
P + P + A+ A+ A + SP L+ D + + PVF +
Sbjct: 1366 RSPIRMS--PARMSPARMSPARMSPARM----SPGRRLEETDESQLERLYKPVFVLKPVS 1419
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
EGQ F+ +V G P P+ W+ +G I + +++ K+ + +L+I
Sbjct: 1420 FKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-------SLIIV 1472
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
DSG +T A N+ G S L V E
Sbjct: 1473 PATPSDSGEWTVVAQNRAGRSSISVILTVEAVE 1505
Score = 85.1 bits (209), Expect = 4e-16
Identities = 98/451 (21%), Positives = 166/451 (36%), Gaps = 60/451 (13%)
Query: 193 QENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTP 252
QE + + R +V P + + V + KR ++ + + A T
Sbjct: 26337 QEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTET 26396
Query: 253 GSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG--IPPPQVRWYCEGKELE 310
+P+ P+ PP+ TQ L++ E + L C+V + +V WY +GK+L+
Sbjct: 26397 KPTPTEKVQHLPVSAPPKITQFLKAEASKEIAK--LTCVVESSVLRAKEVTWYKDGKKLK 26454
Query: 311 NSPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGD 369
+ A + L I E D G Y C S GT T+ + + S
Sbjct: 26455 ENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH---- 26510
Query: 370 PNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK 429
E++++I + + T S V P+A +
Sbjct: 26511 ---EKVSKISETKKSDQKTTESTVTRKTEPKAP--------------------------E 26541
Query: 430 PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
PI + PV LQ+ + S + F + G P P W ++G I +++ + K
Sbjct: 26542 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGG 26601
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANS 549
E I + DSG +TCT N G+VSS +L ++ +D S
Sbjct: 26602 FFLE--------IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTE-----AQKVS 26648
Query: 550 TTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFN---LPEDD 606
T + I PQ E S + L + +E +S ++ L+ + + E+
Sbjct: 26649 TQKTSEITPQKKAVVQEEIS-----QKALRSEEIKMSEAKSQEKLALKEEASKVLISEEV 26703
Query: 607 KGSEASS-EAGVVTTRQTRPDSFQERFNGQA 636
K S A+S E +V T+ E A
Sbjct: 26704 KKSAATSLEKSIVHEEITKTSQASEEVRTHA 26734
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/385 (25%), Positives = 159/385 (41%), Gaps = 73/385 (18%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GT 1001
+ P+F ++LK+ + EGS + + G P P + W K+ I +++ K+R EG G
Sbjct: 1508 VKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS-DIIVPHKYPKIRIEGTKGE 1566
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRIS--CSGHLMVQSL---PIRSRLTSAGQSHRGRS 1056
+L I+ST S D YT A N GR + C ++ V+ P R + G ++R +
Sbjct: 1567 AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRG-TYRAKE 1625
Query: 1057 RVQERDKEPLQERFFRPHFLQAPGDMVAHEG-------------RLCRL-----DCKVSG 1098
+ + EPL R+ + + + GD+ E RL R +C+++
Sbjct: 1626 -IAAPELEPLHLRYGQEQWEE--GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTP 1682
Query: 1099 LPPPELT--WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNS 1156
+ P + WL +G+P L A+ ++ E G SL RD+G C ATNK G +
Sbjct: 1683 IGDPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDH 1741
Query: 1157 FSLELSV--------------------------------------VAKEVKKAPVILEKL 1178
S L V ++ K+ P I+
Sbjct: 1742 TSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYP 1801
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ V EG R CRV G P P W + + I ++ R + D Y L I K
Sbjct: 1802 EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK-RFRVRYDGIHY--LDIVDCKS 1858
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDI 1263
D G ++A+N G++ +L+I
Sbjct: 1859 YDTGEVKVTAENPEGVIEHKVKLEI 1883
Score = 84.7 bits (208), Expect = 5e-16
Identities = 67/235 (28%), Positives = 97/235 (41%), Gaps = 16/235 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKI--VGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
P F K+L R+ P F C++ +G P V W DGK + N +M E G C
Sbjct: 1657 PFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANR-LRMINEF-GYC 1714
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL S D G T A N G S L+V+ + + +G R++E +
Sbjct: 1715 SLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELE 1774
Query: 1063 KEPL----------QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ Q+ +P + P + EG R C+V+G P P++ W LNGQ
Sbjct: 1775 RMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ- 1833
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
L S + VR G+H L I D G K A N G ++L + +E
Sbjct: 1834 -LIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRE 1887
Score = 84.3 bits (207), Expect = 7e-16
Identities = 76/282 (26%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 261 YEEPLGQPPRFTQKLRSREVPEGTRVQLDCIV--VGIPPPQVRWYCEGKELENSPDIHIV 318
Y++ Q P F +KL S + +C + +G P V W +GK LE + + ++
Sbjct: 1649 YDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI 1708
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--SDSEGDPNKEEMN 376
SL A+ D+G +C A+N YGTD TSA + ++ S +S+ ++ +
Sbjct: 1709 NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQ 1768
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ-QCQSPTNYLQGLDGKPIIAAP 435
RI++ + + H A V T Q + Q P I+ P
Sbjct: 1769 RIEE-----------------LERMAHEGALTGVTTDQKEKQKP----------DIVLYP 1801
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
++L EG+ F CRV G P PKV WY G LI S FR+ +
Sbjct: 1802 EPVRVL------EGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV---------RYD 1846
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
I L I + + D+G TA N G + +L ++ ED
Sbjct: 1847 GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRED 1888
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/120 (39%), Positives = 64/120 (53%), Gaps = 8/120 (6%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
+ P L+N++ EG+ V EC + G PSP V WYRE IE S DF+I +
Sbjct: 894 VTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ----- 948
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTT 551
I L+I E FAEDSG FTC+A N+ GTVS+ L V+ +E+ + + TT
Sbjct: 949 ---SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTT 1005
Score = 82.0 bits (201), Expect = 3e-15
Identities = 79/338 (23%), Positives = 131/338 (38%), Gaps = 46/338 (13%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L PR T ++RS VP G + V P +V+WY G EL+ S IH +
Sbjct: 26065 LDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVL 26124
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN-- 382
+L I + +D+G Y +N G S A + + G + EE+ R P
Sbjct: 26125 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT 26184
Query: 383 -----EVSSPPTTSAV-IPPAVPQAQHLVAQPR--VATIQQCQSPTNYLQGLDGKPI--- 431
VSS TS + +V + + + + R +++ + S L+ K +
Sbjct: 26185 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 26244
Query: 432 ---------IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+AA + TK ++++ EG+ F C G P P V W R+G ++ S +
Sbjct: 26245 STTRKIKTTLAARILTKP-RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ 26303
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ K +S T I+ V A D G ++ N G ++
Sbjct: 26304 VTTTKYKS--------TFEISSVQASDEGNYSVVVENS------------EGKQEAEFTL 26343
Query: 543 SLHSANSTTNLAAIEPQ---PSPPHSEPPSVEQPPKPK 577
++ A T P+ P P P +V+ P + K
Sbjct: 26344 TIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 26381
Score = 79.0 bits (193), Expect = 3e-14
Identities = 93/374 (24%), Positives = 153/374 (40%), Gaps = 67/374 (17%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
A P F + LQ+++ +G V + RV G P+P V++YR+G I+ S DF+I Q+
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQE------ 155
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED--------LSNNGSL 544
++ +L+IAE + EDSG ++ A+N G +S A+L V+G E+ + + +
Sbjct: 156 --GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213
Query: 545 HSANST------------TNLAAIE------PQPSPPHSEPPSVEQPPKPKLE-----GV 581
+ T ++A +E PH PP + PPKPK +
Sbjct: 214 SESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRI--PPKPKSRSPTPPSI 271
Query: 582 LVNHNEPRSSSRIGLR------VHFNLPEDDKGSEASSEAGVVTT--RQTRPDSFQERFN 633
R S +R H P S A + T+ R R +
Sbjct: 272 AAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQ 331
Query: 634 GQATKT-PEPSSPVKEPPPVLAKPKLDS-----TQLQQLHNQVLLE-QHQLQNPPP-SSP 685
T PE P K+ V + + + T Q+ + E ++ +Q S
Sbjct: 332 ASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGA 391
Query: 686 KEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVF 745
S++ S A AV T +K+VK + ++ ++A T A +A PV
Sbjct: 392 AGAAASVSASASYAAEAVATGAKEVKQDADKSAAVA--------TVVAAVDMARVREPV- 442
Query: 746 TLSSTPQTIQRTVS 759
+S+ QT QRT +
Sbjct: 443 -ISAVEQTAQRTTT 455
Score = 78.2 bits (191), Expect = 5e-14
Identities = 63/231 (27%), Positives = 93/231 (40%), Gaps = 16/231 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P LK+ V EG VT C I G P P V W+++ QI + G L
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDF--QITFQSGIARL 954
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ--------SLPIRSRLTSAGQSHRGRS 1056
I ++D G +T A N G +S S +L VQ + + + T+ +
Sbjct: 955 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014
Query: 1057 RVQERDKEPLQERF-----FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQ 1111
V D +E+ P+F+ P EG C+V G P P + W +G
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074
Query: 1112 PVLPDASHKMLV-RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P+ +K+ ++TG L+I DAG Y + NK G+ S S L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 77.8 bits (190), Expect = 6e-14
Identities = 70/281 (24%), Positives = 114/281 (40%), Gaps = 35/281 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSL 326
P F +KL++ + EG+R+++ G P P + W + P I I +L
Sbjct: 1510 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1569
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I +D+ Y+ A N G D+T ++ +E V ++ E
Sbjct: 1570 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE-VEFAEPE------------------- 1609
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-LDGKPIIAAPVFTKMLQNLS 445
P +IP +A+ + A P + + + +G L K P F K L +L
Sbjct: 1610 -PERKLIIPRGTYRAKEIAA-PELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1667
Query: 446 ASEGQLVVFECRVK--GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
FECR+ G P+ VEW +G +E + R++ + C+L
Sbjct: 1668 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFG--------YCSLDYG 1719
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSL 544
++ DSG TC A+NKYGT + A L V+ + L L
Sbjct: 1720 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQL 1760
Score = 75.1 bits (183), Expect = 4e-13
Identities = 83/355 (23%), Positives = 139/355 (39%), Gaps = 50/355 (14%)
Query: 820 TSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNT--KSPQPVNDDNIR 877
T I +P+ S V+ P P AP P+ K++ + +P D
Sbjct: 24498 TFGISDPLEVSSVVIIKSPFEKP--------GAPGKPTITAVTKDSCVVAWKPPASDGGA 24549
Query: 878 ETKNAVIRDLGKK------ITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDE 931
+ +N + KK +T ++R + + + + + L E + E + E
Sbjct: 24550 KIRNYYLEKREKKQNKWISVTTEEIR--ETVFSVKNLIEGLEYEFRVKCENLGGESEWSE 24607
Query: 932 IQHDEIPTGKCI--APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRN 989
I P AP F + L++ V S T CK+ G P P V W++ GK+I
Sbjct: 24608 ISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 24667
Query: 990 EHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG 1049
+++ G L I S T DD Y + A N G +S + L V+ +P + L
Sbjct: 24668 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHL---- 24722
Query: 1050 QSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
P L+ G + A G + + SG P P +TW
Sbjct: 24723 -----------------------PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITW-QK 24758
Query: 1110 GQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
GQ ++ + H ++ SL+ + + ++DAG Y A N+ G + ++EL V
Sbjct: 24759 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 24813
Score = 74.3 bits (181), Expect = 7e-13
Identities = 64/238 (26%), Positives = 107/238 (44%), Gaps = 37/238 (15%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP K +K G +C+IVG P+P + W++ GK++ + ++ KM +G T +
Sbjct: 24227 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKY-KMSSDG-RTHT 24284
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L + + +D+G YT +A N G + S L++Q+ P Q H G
Sbjct: 24285 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP---------QFHPG--------- 24326
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
PL+E+++ G RL G P P +TW +GQ +L + S + +
Sbjct: 24327 YPLKEKYY------------GAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQN-SENITI 24372
Query: 1124 RETGVHSLLIDPLTQR--DAGTYKCIATNKTGQNSFSLELSVVAKEVK-KAPVILEKL 1178
T ++ L+ QR AG YK +N G L++ + K K P+++E L
Sbjct: 24373 ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 24430
Score = 74.3 bits (181), Expect = 7e-13
Identities = 79/326 (24%), Positives = 123/326 (37%), Gaps = 44/326 (13%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + + + EG V FTC+I G P P++ WFK+ IS + R S
Sbjct: 26828 APAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR--NVYS 26885
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL---PIRSRL--TSAGQSHRGRSRV 1058
L I + + D G YTI A N +G+ S + LMV L P R + TS S +G
Sbjct: 26886 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSS 26945
Query: 1059 QE-RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA 1117
Q + QE F + M + K + + ++ +
Sbjct: 26946 QSVQMSASKQEASFSSFSSSSASSMT---------EMKFASMSAQSMS-----------S 26985
Query: 1118 SHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEK 1177
+ V + + I +TQ ++ T K + G + +++ P
Sbjct: 26986 MQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG----------IPPKIEALP----- 27030
Query: 1178 LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAK 1237
+ + EG + + C G P P W I + ++T L+I +
Sbjct: 27031 -SDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 27089
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
K D G YTLS NE G S T + I
Sbjct: 27090 KQDGGLYTLSLGNEFGSDSATVNIHI 27115
Score = 73.9 bits (180), Expect = 9e-13
Identities = 57/210 (27%), Positives = 90/210 (42%), Gaps = 8/210 (3%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA-SHKMLVRETGVHSL 1131
PHF + ++ L CKV+G P P + W G+ ++ D +++ + G H L
Sbjct: 24623 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 24682
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
+I +T DA Y+ ATN+ G S + L V P LE + G V +
Sbjct: 24683 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 24742
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ G P PV W+K + I + + + + ++ DAG+Y + AKN
Sbjct: 24743 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 24801
Query: 1252 AGIVSCTARLDIYAQWHHQIP-PPMSVRPS 1280
GI T LD+ +P PP V+ S
Sbjct: 24802 FGIDQKTVELDV-----ADVPDPPRGVKVS 24826
Score = 72.8 bits (177), Expect = 2e-12
Identities = 64/237 (27%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
M +EG+ L ++G ++ W+LNG + ++ V + +L I + RD
Sbjct: 26743 MSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 26799
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPP 1201
G CI+ K G +L++ +KE+ AP + + ++ + EG V C + G P P
Sbjct: 26800 GILTCISKTKEGIVKCQYDLTL-SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26858
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
W K+N I + +S+ + Y+ L I+ A SD+G YT+ AKN G S TA L
Sbjct: 26859 EIEWFKNNLPISIS-SNVSISRSRNVYS-LEIRNASVSDSGKYTIKAKNFRGQCSATASL 26916
Query: 1262 DIYAQWHHQIPPPMSVRPSG--SRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVE 1316
+ + + +R SG S GS +S+ + + ++ + S S+ S+ E
Sbjct: 26917 -MVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTE 26972
Score = 71.6 bits (174), Expect = 5e-12
Identities = 56/184 (30%), Positives = 86/184 (46%), Gaps = 9/184 (4%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
D V+ EG + L ++ E+ W + V D K L ++ ++L+ID + D
Sbjct: 4443 DTVSEEGDIVHLTTSITNAK--EVNWYFENKLVPSDEKFKCL-QDQNTYTLVIDKVNTED 4499
Query: 1141 -AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMP 1199
G Y C A N +G+ + S +L+VV + APVI K++ V GH + C + P
Sbjct: 4500 HQGEYVCEALNDSGKTATSAKLTVVKRA---APVIKRKIEPLEVALGHLAKFTCEIQSAP 4556
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTA 1259
F W K I ++ S+ + + + L I + D G YT A NE G VSCTA
Sbjct: 4557 NVRFQWFKAGREI-YESDKCSI-RSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 4614
Query: 1260 RLDI 1263
L +
Sbjct: 4615 TLTV 4618
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/115 (32%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 938 PTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE 997
PT + P+F + L + EG V F ++ GIP P + W KDG+ +S + ++ E
Sbjct: 25483 PTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLS-LGPNIEIIHE 25541
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSH 1052
G +LHI T +D G Y + A N G SC HL V+ L + + + + H
Sbjct: 25542 GLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEH 25596
Score = 68.6 bits (166), Expect = 4e-11
Identities = 78/309 (25%), Positives = 135/309 (43%), Gaps = 42/309 (13%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S ++LY E + F + ++ +V E R +C V P V+W + +EL+ +
Sbjct: 3000 TSTATLYVE---ARHIEFRKHIKDIKVLEKKRAMFEC-EVSEPDITVQWMKDDQELQITD 3055
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
I I + +H L I D G+Y+ A G + ++A++++EG D K+
Sbjct: 3056 RIKIQKEKYVHRLLIPSTRMSDAGKYTVVA----GGNVSTAKLFVEG---RDVRIRSIKK 3108
Query: 374 EMNRIQKPN-----EVSSPPTTS------AVIPPAVPQAQHLVAQPRV------ATIQQC 416
E+ I+K EV+ + I V + V + R+ T Q
Sbjct: 3109 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSD 3168
Query: 417 QSPTNYLQGLDGKPI---IAAPVFTKMLQNL---SASEGQLVVFECRVKGAPSPKVEWYR 470
++ G + + + AP ++LQ L + G+ F + G P PK+ WY+
Sbjct: 3169 AGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYK 3228
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
E L+ S F K + + + +E TL++ E F ED+ +TC A N YG ++ A L
Sbjct: 3229 EEQLL--STGF-----KCKFLHDGQEY-TLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3280
Query: 531 HVRGNEDLS 539
V E +S
Sbjct: 3281 SVEVPEVVS 3289
Score = 67.0 bits (162), Expect = 1e-10
Identities = 73/294 (24%), Positives = 112/294 (38%), Gaps = 38/294 (12%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L+ EG + C V G +V WY + K+++ S + Q + + L
Sbjct: 3298 PPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLE 3356
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE----------------GVSSSDSEGDPN 371
IAEA+ ED G Y+ ASN G S++A + +E S + ++
Sbjct: 3357 IAEAYPEDEGTYTFVASNAVGQVSSTANLSLEVQALDRQSSGKDVRESAKSQAVADSSFT 3416
Query: 372 KEEMNRIQKPNEVSSPPTTS-----AVIPPAVPQAQHLVAQPR------VATIQQCQSPT 420
KEE QK E+ S +S V + H A + A++ Q T
Sbjct: 3417 KEESKISQK--EIKSFQGSSYEYEVQVFESVSQSSIHTAASVQDTQLCHTASLSQIAEST 3474
Query: 421 NYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
+ + AP LQ+++ G F C +K V W EG IE+S
Sbjct: 3475 ELSKECAKESTGEAPKIFLHLQDVTVKCGDTAQFLCVLKDDSFIDVTWTHEGAKIEESER 3534
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ ++ I L I V D G ++C N G ++ A L V G
Sbjct: 3535 LK--------QSQNGNIQFLTICNVQLVDQGLYSCIVHNDCGERTTSAVLSVEG 3580
Score = 66.6 bits (161), Expect = 1e-10
Identities = 86/381 (22%), Positives = 144/381 (37%), Gaps = 77/381 (20%)
Query: 697 SNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQR 756
S A A+ T K++ A SS K + T P+ P F + TP T +
Sbjct: 787 SIAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYK- 845
Query: 757 TVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIP 816
S V+ K G+SI T T F + G + +
Sbjct: 846 ---------SEAGVEVKKEVGVSI---------TGTTVREERFEVLHGREAK-------- 879
Query: 817 VSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPR------------------SAPSMP-- 856
V+ T+R+ PV +P PPT GL +P++
Sbjct: 880 VTETARVPAPV--------EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 931
Query: 857 ----------------SQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT--FSDVRP 898
G+A+ + + +D+ R T +AV + G T + V+
Sbjct: 932 REDYQIESSIDFQITFQSGIARLMIR--EAFAEDSGRFTCSAV-NEAGTVSTSCYLAVQV 988
Query: 899 NQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVT 957
+++ E + ++ ++ E + +E V +D + ++ G+ AP F + ++
Sbjct: 989 SEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV 1048
Query: 958 EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
EG V F C++ G P P VYW K G ++ + + G C L I T +DD G Y
Sbjct: 1049 EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEY 1108
Query: 1018 TIMAANPQGRISCSGHLMVQS 1038
TI+ N G S S L+ ++
Sbjct: 1109 TIVVRNKHGETSASASLLEEA 1129
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 243 SEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
+E G + P + S+ + G+ P ++++ G QL C +VG P P ++W
Sbjct: 24202 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 24261
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
Y GKEL S + G H+LT+ +ED G Y+C A+N G TS+++ ++ +
Sbjct: 24262 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ-AT 24320
Query: 363 SSDSEGDPNKEE 374
G P KE+
Sbjct: 24321 PQFHPGYPLKEK 24332
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/113 (32%), Positives = 57/113 (50%), Gaps = 1/113 (0%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-NLHSLT 327
P F + L + E EG V + V GIPPP ++W +G+ L P+I I+ G + ++L
Sbjct: 25490 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25549
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
I + EDTG Y A+N G+ S A + +E + E +E +QK
Sbjct: 25550 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEHERHVQK 25602
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 1052 HRGRSRVQE--RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
H ++V E R P++ P + ++ EG L+C +SG P P +TW
Sbjct: 874 HGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRE 933
Query: 1110 GQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEV 1168
+ ++ ++G+ L+I D+G + C A N+ G S S L+V V++E
Sbjct: 934 DYQIESSIDFQITF-QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF 992
Query: 1169 KK----------------------------------------APVILEKLQNCGVPEGHP 1188
+K AP + K + EG
Sbjct: 993 EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGS 1052
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCT---RERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
V C+V G P P YWKK +P T R ++S ++ TG L+I DAG YT
Sbjct: 1053 VVFGCQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQ-TGECKLVISMTFADDAGEYT 1109
Query: 1246 LSAKNEAGIVSCTARL 1261
+ +N+ G S +A L
Sbjct: 1110 IVVRNKHGETSASASL 1125
Score = 65.5 bits (158), Expect = 3e-10
Identities = 63/268 (23%), Positives = 95/268 (35%), Gaps = 68/268 (25%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP FT L ++ G V+ + P P V WY G++++ N
Sbjct: 25381 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIK--------PGDNDK 25432
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
T FE D G Y +++ D + DS K ++ P
Sbjct: 25433 KYT----FESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDS----CKAKLTVTLHP--- 25481
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
PPT S + P+F ++L N
Sbjct: 25482 --PPTDSTL----------------------------------------RPMFKRLLANA 25499
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
EGQ V FE RV G P P ++W ++G + P+ I+ E + L I +
Sbjct: 25500 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIH-------EGLDYYALHIRD 25552
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
ED+G + TA+N G+ S A L V
Sbjct: 25553 TLPEDTGYYRVTATNTAGSTSCQAHLQV 25580
Score = 64.7 bits (156), Expect = 6e-10
Identities = 52/211 (24%), Positives = 86/211 (40%), Gaps = 10/211 (4%)
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
+V W+KDGK++ K N H + DGT L I + T D G Y + G +
Sbjct: 26443 EVTWYKDGKKL-KENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQF 26501
Query: 1035 MVQSL-PIRSRLTSAGQSHRGRSRVQE----RDKEPL--QERFFRPHFLQAPGDMVAHEG 1087
M Q+ I +++ ++ + + E R EP + +P + D
Sbjct: 26502 MGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSD 26561
Query: 1088 RLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCI 1147
+ + K +G P P W +G+ + +K L + G L I D+G Y C
Sbjct: 26562 SVAKFAVKATGEPRPTAIWTKDGKAITQGGKYK-LSEDKGGFFLEIHKTDTSDSGLYTCT 26620
Query: 1148 ATNKTGQNSFSLELSVVA-KEVKKAPVILEK 1177
N G S S +L++ A K+ + V +K
Sbjct: 26621 VKNSAGSVSSSCKLTIKAIKDTEAQKVSTQK 26651
Score = 63.5 bits (153), Expect = 1e-09
Identities = 62/255 (24%), Positives = 104/255 (40%), Gaps = 44/255 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP +R++ V +GS F ++VG P P+ W+K+G +I +R++ D C
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI-ERSDRIYWYWPEDNVCE 2089
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I T++D + + A N G S L+VQ+ + +
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLIT-------------------- 2129
Query: 1064 EPLQERFFRPHFLQAPGDMVAHE-GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F Q D+VA E + +C+ S P ++ W +G V ++M
Sbjct: 2130 -----------FTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDGMEVHEGDKYRM- 2176
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQN 1180
+ VH L I + DA Y C+ + AK + + V+ +++LQ+
Sbjct: 2177 HSDRKVHFLSILTIDTSDAEDYSCVLVEDE-------NVKTTAKLIVEGAVVEFVKELQD 2229
Query: 1181 CGVPEGHPVRLECRV 1195
VPE + LEC V
Sbjct: 2230 IEVPESYSGELECIV 2244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 51/252 (20%)
Query: 282 EGTRVQLDCIVVGIPPP-QVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
EG V+ C + QV WY ++LENS I + L + + + D G Y
Sbjct: 25276 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYR 25335
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C N YG DS+ AE++++GV + + M +I++
Sbjct: 25336 CKVVNDYGEDSSYAELFVKGV--REVYDYYCRRTMKKIKR-------------------- 25373
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
R T++ + P P FT L N +A G+ V F +
Sbjct: 25374 --------RTDTMRLLERP---------------PEFTLPLYNKTAYVGENVRFGVTITV 25410
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P P V WY+ G I+ + K + + + L I V +D +T A NK
Sbjct: 25411 HPEPHVTWYKSGQKIKPGDN-----DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 25465
Query: 521 YGTVSSIAQLHV 532
YG S A+L V
Sbjct: 25466 YGEDSCKAKLTV 25477
Score = 62.0 bits (149), Expect = 4e-09
Identities = 76/296 (25%), Positives = 112/296 (37%), Gaps = 61/296 (20%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
AAPV + ++ L + G L F C ++ AP+ + +W++ G I +S I K
Sbjct: 4527 AAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSK----- 4581
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTN 552
I +L I D G +TC ASN+YG+VS A L V ++
Sbjct: 4582 ---YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV----------TVPGGEKKVR 4628
Query: 553 LAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEAS 612
E +P P +P+ E V EP+ ++ P E
Sbjct: 4629 KLLPERKPEPKEEVVLKSVLRKRPEEEEPKV---EPKKLEKVKKPAVPEPPPPKPVEEV- 4684
Query: 613 SEAGVVTTRQTRPDSFQERFNGQATKTPE--PSSPVKEPPPVLAKPKLDSTQLQQLHNQV 670
E VT R ER + TK PE P+ P+ P P KPK ++
Sbjct: 4685 -EVPTVTKR--------ERKIPEPTKVPEIKPAIPLPAPEP---KPKPEA---------- 4722
Query: 671 LLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSK--QVKAPSSQTFSLARPK 724
+ + PPP P+ P + AP V K + KAP + A+PK
Sbjct: 4723 ---EVKTIKPPPVEPEPTPIA-------APVTVPVVGKKAEAKAPKEEA---AKPK 4765
Score = 60.8 bits (146), Expect = 8e-09
Identities = 81/357 (22%), Positives = 127/357 (35%), Gaps = 67/357 (18%)
Query: 266 GQP--PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV---QA 320
G+P P F K +++ EG V C V G P P V W G L + Q
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQT 1090
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG----VSSSDSEGDPNKEEMN 376
G L I+ F +D G Y+ N +G S SA + E + S E +
Sbjct: 1091 GEC-KLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTA 1149
Query: 377 RIQKPNEVSSPP-----------------------TTSAVIPPAVPQAQHLVAQPRVATI 413
+Q+P + P + V+ V + ++ I
Sbjct: 1150 FVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLI 1209
Query: 414 QQCQ-----SPTNYLQGLDGKPIIAAPV---------FTKMLQNLSASEGQLVVFECRVK 459
++ + + L DG+ +A + F ++N EG V F C++
Sbjct: 1210 KEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMS 1269
Query: 460 GAPSPKVEWYREGTLIEDSPDFRI--LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
G P PK+ WY++G I+ +++ LQ S+ P V ED G +T A
Sbjct: 1270 GYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIP---------VVLPEDEGIYTAFA 1320
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
SN G +L+V L + T + +EP P SV + P
Sbjct: 1321 SNIKGNAICSGKLYVEPAAPL---------GAPTYIPTLEPVSRIRSLSPRSVSRSP 1368
Score = 60.8 bits (146), Expect = 8e-09
Identities = 85/347 (24%), Positives = 134/347 (38%), Gaps = 61/347 (17%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
RV EG F C++ G P PKV W+ +G+ I K + R DG L I S D
Sbjct: 1805 RVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK---RFRVRYDGIHYLDIVDCKSYDT 1861
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G + A NP+G I L +Q Q RS V R EP RP
Sbjct: 1862 GEVKVTAENPEGVIEHKVKLEIQ------------QREDFRS-VLRRAPEP------RPE 1902
Query: 1075 F-LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV----LPDASHKMLVR----- 1124
F + PG + + + ++D V E+ L + + +P+ S ++ +
Sbjct: 1903 FHVHEPGKL---QFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRT 1959
Query: 1125 ETGVHSLLID---PLTQRDAGTYKCIATNKTGQNSFSLELS-----VVAKEVK------- 1169
E G + + ++D + + K ++ EL+ +A+E K
Sbjct: 1960 EEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFK 2019
Query: 1170 ----------KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+AP I E++Q+ V +G RV+G P P W K+ I +RI
Sbjct: 2020 PDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRI 2078
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ L+I+ D+ + A N AG S A L + A+
Sbjct: 2079 YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2125
Score = 60.8 bits (146), Expect = 8e-09
Identities = 82/331 (24%), Positives = 126/331 (38%), Gaps = 67/331 (20%)
Query: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
D+S E+ E PT F + L+ VTE F+C++ V W+++G++I
Sbjct: 6505 DKSVAELLIIEAPTE------FVEHLEDQTVTEFDDAVFSCQL-SREKANVKWYRNGREI 6557
Query: 986 SKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
E K + E DG+ L I+ DD+ Y + + R L V+ +P+
Sbjct: 6558 K---EGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSR----ARLFVEEIPVE-- 6608
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERFFRP--HFLQAPGDMVAHEGRLCRLDCKVSGLPPP 1102
RP L+APG V L +
Sbjct: 6609 -------------------------IIRPPQDILEAPGADVVFLAELNK--------DKV 6635
Query: 1103 ELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELS 1162
E+ WL N V+ H+M+ E +H L I + RD G Y+ IA +K +
Sbjct: 6636 EVQWLRNNMVVVQGDKHQMM-SEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKL----- 6689
Query: 1163 VVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
E+ AP I Q+ V G P+ + P W K+NE P + + I
Sbjct: 6690 ----ELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENE--PLSTKTIDTT 6743
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ T + L AKK D G Y + +N+ G
Sbjct: 6744 AEQTSFRIL---EAKKGDKGRYKIVLQNKHG 6771
Score = 60.5 bits (145), Expect = 1e-08
Identities = 145/725 (20%), Positives = 229/725 (31%), Gaps = 133/725 (18%)
Query: 365 DSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
D+E E R + P+ VSS + S A + A Q S Y +
Sbjct: 25998 DTERRSPTPERTRPRSPSPVSSERSLSRFERSARFDIFSRYESMKAALKTQKTSERKY-E 26056
Query: 425 GLDGKPIIA--APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
L +P AP T +++ GQ F V+ P+ +V+WY G +++S
Sbjct: 26057 VLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH 26116
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ TL I + +DSG + +N G S A L V G +
Sbjct: 26117 Y--------TNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGD------ 26162
Query: 543 SLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNL 602
T A+ P S P + + + SSS ++
Sbjct: 26163 -------YTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTE 26215
Query: 603 PEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQ 662
+ S S + + + S +E+ + KT + +L KP+
Sbjct: 26216 TRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR-------ILTKPR----- 26263
Query: 663 LQQLHNQVLLEQHQLQNPPPSSPKEFPFSM-----TVLNSNAPPAVTTSSKQVKAPSSQT 717
+ + E + + + P VL+++A VTT+ + S
Sbjct: 26264 -----SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 26318
Query: 718 FSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGG 777
+ Y N+ A FTL TIQ+ E + S P V++ P
Sbjct: 26319 QASDEGNYSVVVENSEGKQEAE-----FTL-----TIQKARVTEKAVTSPPRVKSPEPRV 26368
Query: 778 LSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSL 837
S + P P P P+ VSP PT
Sbjct: 26369 KSPEAVKSPKRVKSPEPS------------HPKAVSPTETKPT----------------- 26399
Query: 838 PAIPPTNAMGLPRSAPSMPSQGL---AKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT-- 892
P LP SAP +Q L A K V + ++ K GKK+
Sbjct: 26400 ---PTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKEN 26456
Query: 893 ----FSDVRPNQQEYKISSFEQRLMNEI--------------------EFRLERTPVDES 928
F E KI++ + E F+ V +
Sbjct: 26457 GHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 26516
Query: 929 DDEIQHDEIPTGKCIA--------------PIFDKRLKHFRVTEGSPVTFTCKIVGIPVP 974
+ + D+ T + P+ L+ V+ S F K G P P
Sbjct: 26517 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 26576
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
W KDGK I++ ++ E G L I T + D G YT N G +S S L
Sbjct: 26577 TAIWTKDGKAITQGGKY--KLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 26634
Query: 1035 MVQSL 1039
++++
Sbjct: 26635 TIKAI 26639
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT ++ P + AP + +Q+ + +G F RV G P P+ EWY+ G IE S
Sbjct: 2016 PTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERS 2075
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
RI P + +C LVI +V AEDS A N G SS A L V+ + +
Sbjct: 2076 D--RIYWYWPE-----DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLI 2128
Query: 539 SNNGSLHS--ANSTTNLAAIEPQPSPP 563
+ L A +A E + S P
Sbjct: 2129 TFTQELQDVVAKEKDTMATFECETSEP 2155
Score = 58.9 bits (141), Expect = 3e-08
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 16/147 (10%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG----VPE 1185
S L++ L + ++ A N+ G++ SL L+VV ++ + P I +L G V
Sbjct: 9048 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 9107
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETI--------PCTRERISMHQDTTGYACLLIQPAK 1237
G PV + V G+P P W K NET+ T+E +S + T L I A
Sbjct: 9108 GEPVHIPADVTGLPMPKIEWSK-NETVIEKPTDALQITKEEVSRSEAKTE---LSIPKAV 9163
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDIY 1264
+ D G YT++A N G V +++Y
Sbjct: 9164 REDKGTYTVTASNRLGSVFRNVHVEVY 9190
Score = 58.2 bits (139), Expect = 5e-08
Identities = 40/128 (31%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
K AP+ ++++ V G FTC+I P + WFK G++I + ++ C + R
Sbjct: 4525 KRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE-SDKCSI-RSSKY 4582
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
SL I T D G YT A+N G +SC+ L V T G + R + E
Sbjct: 4583 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV---------TVPGGEKKVRKLLPE 4633
Query: 1061 RDKEPLQE 1068
R EP +E
Sbjct: 4634 RKPEPKEE 4641
Score = 57.8 bits (138), Expect = 7e-08
Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F +RL+ V +GS V ++ GIP P V +++DG +I + ++ +EGD SL
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDF-QISQEGD-LYSL 161
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ---SLPIRSRLTSAGQSHRGRSRVQER 1061
I +D G Y++ A N GR + + L+VQ +P + T + SR Q R
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESR-QTR 220
Query: 1062 DKEPLQERF 1070
++ ++ F
Sbjct: 221 IEKKIEAHF 229
Score = 56.6 bits (135), Expect = 2e-07
Identities = 52/196 (26%), Positives = 80/196 (40%), Gaps = 19/196 (9%)
Query: 849 PRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSF 908
PRS P QG + + +P D R K T S + N E+++ F
Sbjct: 9013 PRSNGGSPIQGYIIEKRRHDKP---DFERVNKRLCP-------TTSFLVENLDEHQMYEF 9062
Query: 909 EQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKI 968
+ +NEI E P + IQ DE+P I R +V G PV +
Sbjct: 9063 RVKAVNEIG---ESEPSLPLNVVIQDDEVPP--TIKLRLSVRGDTIKVKAGEPVHIPADV 9117
Query: 969 VGIPVPKVYWFKDGKQISKRNEHCKMRRE----GDGTCSLHIESTTSDDDGNYTIMAANP 1024
G+P+PK+ W K+ I K + ++ +E + L I +D G YT+ A+N
Sbjct: 9118 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNR 9177
Query: 1025 QGRISCSGHLMVQSLP 1040
G + + H+ V P
Sbjct: 9178 LGSVFRNVHVEVYDRP 9193
Score = 56.6 bits (135), Expect = 2e-07
Identities = 105/539 (19%), Positives = 201/539 (37%), Gaps = 76/539 (14%)
Query: 74 ESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQ 133
+ + A+ P K+ E + + SP+ +K SP P SPT +K +P
Sbjct: 26346 QKARVTEKAVTSPPRVKSPEPRVK---SPEAVK-SPKRVKSPEPSHPKAVSPTETKPTPT 26401
Query: 134 EAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKS-KLESQNKVM 192
E + Q+ + K+ A+ +E++ L S +R + +K K +N
Sbjct: 26402 E--KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHF 26459
Query: 193 QENSSS-------FSDLSERRERSSVPIPIPADTRDNEVN--------HALEQQEAKRRE 237
Q + S+ ++L+E + V I + ++ N ++ ++ +K E
Sbjct: 26460 QFHYSADGTYELKINNLTESDQGEYV-CEISGEGGTSKTNLQFMGQAFKSIHEKVSKISE 26518
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPP 297
+++ + T + P + EP+ P L+ V + + G P
Sbjct: 26519 TKKSDQKTTESTVTRKTEPKA---PEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPR 26575
Query: 298 PQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIY 357
P W +GK + + + L I + D+G Y+C N G+ S+S ++
Sbjct: 26576 PTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLT 26635
Query: 358 IEGVSSSD---------SEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQP 408
I+ + ++ SE P K+ + + E+S S I + ++Q +A
Sbjct: 26636 IKAIKDTEAQKVSTQKTSEITPQKKAVVQ----EEISQKALRSEEIKMSEAKSQEKLALK 26691
Query: 409 RVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ----------------NLSASEGQLV 452
A+ + I TK Q +S +EGQ +
Sbjct: 26692 EEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 26751
Query: 453 VFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGC 512
V + + GA V+W G + +S ++R ++ ++ TL I + D G
Sbjct: 26752 VLKANIAGATD--VKWVLNGVELTNSEEYRY------GVSGSDQ--TLTIKQASHRDEGI 26801
Query: 513 FTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL---------AAIEPQPSP 562
TC + K G V Q + +++LS+ + S + N+ I +PSP
Sbjct: 26802 LTCISKTKEGIVK--CQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26858
Score = 55.8 bits (133), Expect = 3e-07
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 48/323 (14%)
Query: 59 DLPDLSAFLSQ---EELDESVN-LARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFE 114
+L D AF+SQ + ++E N L I+ +P + E + K P + + ++S
Sbjct: 26824 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEP---SPEIEWFKNNLPISISSNVSISRS 26880
Query: 115 PNFCQDNPRSPTSSKESPQEAKRPQY---CSETQS-----------KKVFLNKAADFIEE 160
N R+ + S K + CS T S ++V L + D
Sbjct: 26881 RNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGD---- 26936
Query: 161 LSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTR 220
+SL S SS+ ++ A K S +SSS S ++E + S
Sbjct: 26937 -TSLQGSFSSQSVQMSASKQEAS-------FSSFSSSSASSMTEMKFASMSA-------- 26980
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
++ + E ++ T SS S + G PP+ +
Sbjct: 26981 -----QSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISI 27035
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD--IHIVQAGNLHSLTIAEAFEEDTGR 338
EG + + C G P P+V W C G+++ + HI +L +L I + ++D G
Sbjct: 27036 DEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGL 27095
Query: 339 YSCFASNIYGTDSTSAEIYIEGV 361
Y+ N +G+DS + I+I +
Sbjct: 27096 YTLSLGNEFGSDSATVNIHIRSI 27118
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 2/95 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENS--PDIHIVQAGNLH 324
Q P FTQ L+S V EG+ + + G P P+V W+ +G+ + S P + I +
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
LTI + ++GRYS A+N G +++AE+ ++
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/149 (28%), Positives = 69/149 (46%), Gaps = 10/149 (6%)
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
HK ++ET ++D + ++ N+ G++ + VV KE + PV+ KL
Sbjct: 11846 HKGSIKET---HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKL 11902
Query: 1179 QNC-GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE---RISMHQDTTGYACLLIQ 1234
V G +RLE V G P P W KD + TR +I D++ ++ +
Sbjct: 11903 SGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS---LT 11959
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
AK+SD G Y ++A N AG A +++
Sbjct: 11960 KAKRSDGGKYVVTATNTAGSFVAYATVNV 11988
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACL 1231
P ++ L+N V EG V LEC + G P P W +++ I + + Q +G A L
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ--SGIARL 954
Query: 1232 LIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+I+ A D+G +T SA NEAG VS + L +
Sbjct: 955 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 986
Score = 54.3 bits (129), Expect = 8e-07
Identities = 78/382 (20%), Positives = 141/382 (36%), Gaps = 55/382 (14%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS--PDFRILQKKPRSM 491
AP FT+ LQ++ EG FE + G P P+V W+R+G +I S P +I R+
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA- 63
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN------NGSLH 545
L I V +SG ++ A+N G +S A+L V+ N + ++
Sbjct: 64 -------KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVR 116
Query: 546 SANSTTNLAAIEPQPSPP---HSEPPSVEQ------PPKPKLEGVLVNHNEPRSSSRIGL 596
+ + P+P + + ++ + L +L+ P S +
Sbjct: 117 QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 597 RVHFNLPEDDKGSE----------------ASSEAGVVTTRQTRPD-SFQERFNGQATKT 639
++ +E S A + +RQTR + + F+ ++ T
Sbjct: 177 NATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT 236
Query: 640 PE--------PSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFS 691
E P K PP + KPK S + + L + Q PS + P
Sbjct: 237 VEMVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQ----SPSPIRHSPSP 292
Query: 692 MTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTP 751
+ + + P V + S + +S S+ P + +T AT P P +
Sbjct: 293 VRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVAT-GPEVPPPWKQEGYV 351
Query: 752 QTIQRTVSKESLLVSHPSVQTK 773
+ +E+ L + ++T+
Sbjct: 352 ASSSEAEMRETTLTTSTQIRTE 373
Score = 53.1 bits (126), Expect = 2e-06
Identities = 68/307 (22%), Positives = 117/307 (38%), Gaps = 39/307 (12%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H L ++ K +A + A T ++L+ +EP P FT+ L + V EG
Sbjct: 5945 HTLTLRDVKLEDAGEVQLTAKDFKTH-----ANLFVKEP---PVEFTKPLEDQTVEEGAT 5996
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+C V +V+W+ G E+ S IV G + L I + ED Y+C A +
Sbjct: 5997 AVLEC-EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 6055
Query: 346 I--------------YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
+ T ++ + ++ + E ++ + E+
Sbjct: 6056 FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYD 6115
Query: 392 AVIPPAVPQAQHLVAQPRVATIQ---QCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+ AV + LV + + C+ T G+ + VFTK L N+ SE
Sbjct: 6116 IISKGAV---RILVINKCLLDDEAEYSCEVRTARTSGM-LTVLEEEAVFTKNLANIEVSE 6171
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C V P +V WY+ I ++ + IL + + + LVI E
Sbjct: 6172 TDTIKLVCEV-SKPGAEVIWYKGDEEIIETGRYEILTEGRKRI--------LVIQNAHLE 6222
Query: 509 DSGCFTC 515
D+G + C
Sbjct: 6223 DAGNYNC 6229
Score = 53.1 bits (126), Expect = 2e-06
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 4/128 (3%)
Query: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV---PEGTR 285
E E +R E A AA + P S + ++ + +PPR ++ R+V G
Sbjct: 19443 ELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV-EPPRVMMDVKFRDVIVVKAGEV 19501
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
++++ + G P P + W +G E+E I+ N LT+ + DTG+Y N
Sbjct: 19502 LKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKN 19561
Query: 346 IYGTDSTS 353
+ GT S +
Sbjct: 19562 VAGTRSVA 19569
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG 294
R + E E+ + + +P S + P+ Q P F ++LR+ V + L C V G
Sbjct: 24593 RVKCENLGGESEWSEISEPITPKS---DVPI-QAPHFKEELRNLNVRYQSNATLVCKVTG 24648
Query: 295 IPPPQVRWYCEGKELENSPDIHIVQ--AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P V+WY +GKE+ + +Q G H L IA ++D Y A+N G+ S
Sbjct: 24649 HPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSG 24708
Query: 353 SAEIYIE 359
+A + +E
Sbjct: 24709 TASLEVE 24715
Score = 52.4 bits (124), Expect = 3e-06
Identities = 71/307 (23%), Positives = 109/307 (35%), Gaps = 63/307 (20%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K LK+ VTE FT ++ V V W K+G + + NE + +G SL I++
Sbjct: 2665 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGV-VLESNEKYAISVKGT-IYSLRIKN 2722
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
D+ Y GR+ S L V+++ I
Sbjct: 2723 CAIVDESVYGFRL----GRLGASARLHVETVKI--------------------------- 2751
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ P D+ A E + VS P + W + P H+ LV E V
Sbjct: 2752 -------IKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHR-LVSERKV 2802
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
H L++ ++ DAG Y + GQ +L V + K ++N VPE
Sbjct: 2803 HKLMLQNISPSDAGEYTAV----VGQLECKAKLFVETLHITKT------MKNIEVPETKT 2852
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQPAKKSDAGWY 1244
EC V P + K E + +I +HQ L+I D+ Y
Sbjct: 2853 ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQ-------LIIMNTSTEDSAEY 2905
Query: 1245 TLSAKNE 1251
T N+
Sbjct: 2906 TFVCGND 2912
Score = 52.4 bits (124), Expect = 3e-06
Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 11/138 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRF---TQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
A G++ P P + ++ L +PP R + + G ++L I+ G+P P+V W
Sbjct: 10889 AAGESDPAHVPEPVLVKDRL-EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW 10947
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
E ++ I + G+ L I A ED G YS N G+ + S ++ +
Sbjct: 10948 KKEDRDAPTKARIDVTPVGS--KLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLV---- 11001
Query: 363 SSDSEGDPNKEEMNRIQK 380
D G P E++ I+K
Sbjct: 11002 -LDKPGPPRDLEVSEIRK 11018
Score = 52.4 bits (124), Expect = 3e-06
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVILEKLQN 1180
+V E+ V + ++ L+ ++ A N+ G++ L + V+AK++ P +
Sbjct: 17956 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 18015
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
+ G +++E VIG P P W KD E + T R+++ + T L I+ K D
Sbjct: 18016 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQT-TRVNVEETATS-TVLHIKEGNKDD 18073
Query: 1241 AGWYTLSAKNEAG 1253
G YT++A N AG
Sbjct: 18074 FGKYTVTATNSAG 18086
Score = 52.0 bits (123), Expect = 4e-06
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP K +++++ G+ C++ G P P ++WYR G ++Q + M+
Sbjct: 24227 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGK--------ELIQSRKYKMSS 24278
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
TL + ED G +TC A+N+ G V + ++L
Sbjct: 24279 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 24315
Score = 52.0 bits (123), Expect = 4e-06
Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRS 490
I AP F + L+NL+ C+V G P P V+WYR+G +I D +RI + K
Sbjct: 24620 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFK--- 24676
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L+IA V +D+ + A+N+ G+VS A L V
Sbjct: 24677 ----GGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24714
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/135 (30%), Positives = 66/135 (48%), Gaps = 14/135 (10%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP-------EGHP 1188
LT+ T++ A N+ G+ + S E++VVA++ AP + K G+P E
Sbjct: 13640 LTEGKEYTFRVSAENENGEGTPS-EITVVARDDVVAPDLDLK----GLPDLCYLAKENSN 13694
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
RL+ + G P P WKK + + T R+S+ L++ +KSDAG YT++
Sbjct: 13695 FRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAVN-TTLIVYDCQKSDAGKYTITL 13752
Query: 1249 KNEAGIVSCTARLDI 1263
KN AG T + +
Sbjct: 13753 KNVAGTKEGTISIKV 13767
Score = 51.2 bits (121), Expect = 6e-06
Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 18/187 (9%)
Query: 215 IPAD--TRDNEVNHALEQQEAKRREAEQAAS------EAAGGDTTPGSSPSSLYYEEPLG 266
+P D R N H + Q+E E+ A + +P S PS
Sbjct: 12926 LPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAEN 12985
Query: 267 QPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PPR + + V GT V LD V G P P V W +G L+ + I + NL
Sbjct: 12986 VPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL 13045
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
+L + +D+G Y+ A N G+ S + ++ + D G P ++N++
Sbjct: 13046 CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV-----LDKPGPPASVKINKMYSDRA 13100
Query: 384 VSS--PP 388
+ S PP
Sbjct: 13101 MLSWEPP 13107
Score = 51.2 bits (121), Expect = 6e-06
Identities = 27/87 (31%), Positives = 41/87 (47%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T ++ VP G V+L + G PPP W+ G +L S + + + LTI E
Sbjct: 23437 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET 23496
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYI 358
DTG Y+ N+ GT S + ++ I
Sbjct: 23497 TIRDTGEYTLELKNVTGTTSETIKVII 23523
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 8/89 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
L+ G V + V G P P V W ++GTL++ + + MA +CTL +
Sbjct: 13000 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK--------MAMQRNLCTLELF 13051
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
V +DSG +T TA N G+ S+ +L V
Sbjct: 13052 SVNRKDSGDYTITAENSSGSKSATIKLKV 13080
Score = 50.1 bits (118), Expect = 1e-05
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVR 1190
+I LTQ + ++ +A N+ G++ SL + +VAK++ P + + V G ++
Sbjct: 16884 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 16943
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E + G P P W KD + T RI++ D+ L I+ K D G Y ++ N
Sbjct: 16944 IEVPISGRPKPTITWTKDGLPLKQT-TRINV-TDSLDLTTLSIKETHKDDGGQYGITVAN 17001
Query: 1251 EAG 1253
G
Sbjct: 17002 VVG 17004
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 14/144 (9%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV-----ILEKLQNCGVPEGHPVR 1190
LT+ + T++ +A N G+++ V+ KE P I +KL G ++
Sbjct: 14722 LTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--GDNIK 14779
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E V+G P P WKK ++ + T +R++ T L I +SD+G Y L+A+N
Sbjct: 14780 VEIPVLGRPKPTVTWKKGDQILKQT-QRVNFETTATS-TILNINECVRSDSGPYPLTARN 14837
Query: 1251 EAGIVSCTARLDIYAQWHHQIPPP 1274
G V D+ H IP P
Sbjct: 14838 IVGEVG-----DVITIQVHDIPGP 14856
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/295 (24%), Positives = 113/295 (38%), Gaps = 55/295 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDD 1013
+V EG V K+ V V W KDG+++ + H + ++ L IE T +D
Sbjct: 2320 KVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRVHIVIDKQSH---MLLIEDMTKED 2375
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
GNY+ P +S SG + V S+ + + L
Sbjct: 2376 AGNYSFTI--PALGLSTSGRVSVYSVDVITPLK--------------------------- 2406
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
D+ EG L+CKVS + W LN + + PD + +V+ T L+I
Sbjct: 2407 -------DVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT-KQRLVI 2458
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ D G YK I G+ + LSV +++K I+ L++ E V E
Sbjct: 2459 NRTHASDEGPYKLI----VGRVETNCNLSV--EKIK----IIRGLRDLTCTETQNVVFEV 2508
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+ V + KD E P ++ +I H L + K D G YT A
Sbjct: 2509 ELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYK---LTVLNMMKDDEGKYTFYA 2560
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/229 (27%), Positives = 91/229 (39%), Gaps = 43/229 (18%)
Query: 844 NAMGLPRSAPSMPSQGLAKKNTKSPQPVND--DNIRETK----NAVIRDLGKKIT----- 892
N+ GL S+PS PS+ + P D D RET N +RD G KI
Sbjct: 21530 NSAGL--SSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE 21587
Query: 893 ------------FSDVRPNQQEYKISSFEQRLMNEIEFRL-ERTPVDESDDEIQHDEI-- 937
F+DV ++ +Y ++ + EFR+ R V Q I
Sbjct: 21588 KRQGNERWVRCNFTDV--SECQYTVTGLSPG--DRYEFRIIARNAVGTISPPSQSSGIIM 21643
Query: 938 PTGKCIAPIFDKRLKHFR---VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKM 994
+ + PI + ++F + G + + G PVP+V WFKDG +I KR M
Sbjct: 21644 TRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR-----M 21698
Query: 995 RREGD---GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
E G+ SL + T D G YT+ A N G + VQ P
Sbjct: 21699 NMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 21747
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 8/126 (6%)
Query: 1143 TYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
+++ A N G + +S ++ + E+ + + + + G +RL V G
Sbjct: 23109 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGR 23168
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
PPPV W K + ++ T Y+ L++ + DAG YT+ A+N++G S T
Sbjct: 23169 PPPVITWSKQGIDLASR----AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSAT 23224
Query: 1259 ARLDIY 1264
+ +Y
Sbjct: 23225 VLVKVY 23230
Score = 48.9 bits (115), Expect = 3e-05
Identities = 42/185 (22%), Positives = 74/185 (40%), Gaps = 13/185 (7%)
Query: 187 SQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRR---------- 236
+ KV +E+ S R E + + + + + E+ K +
Sbjct: 1940 THEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKEL 1999
Query: 237 -EAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
E E+ A G T P P + P + P+ ++++S+ V +G+ VVG
Sbjct: 2000 TEEEKKALAEEGKITIPTFKPDKIELS-PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGK 2058
Query: 296 PPPQVRWYCEGKELENSPDIH-IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P+ WY G ++E S I+ N+ L I + ED+ A NI G S+ A
Sbjct: 2059 PDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHA 2118
Query: 355 EIYIE 359
+ ++
Sbjct: 2119 FLLVQ 2123
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E R E A AAG + P S ++ + + PPR + + ++ V G ++
Sbjct: 16200 EDHRYEFRVIARNAAGVFSEPSESTGAITARDEV-DPPRISMDPKYKDTIVVHAGESFKV 16258
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
D + G P P ++W +EL N+ + I SL++ +A D+G Y A N+ G
Sbjct: 16259 DADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG 16318
Query: 349 TDSTSAEIYI 358
S + + +
Sbjct: 16319 ERSVTVNVKV 16328
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/94 (30%), Positives = 44/94 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP E+L+N V L C+V G P P+ W + + I + + + GY
Sbjct: 24621 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 24680
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L+I DA Y + A N+ G VS TA L++
Sbjct: 24681 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24714
Score = 48.5 bits (114), Expect = 4e-05
Identities = 101/438 (23%), Positives = 156/438 (35%), Gaps = 100/438 (22%)
Query: 872 NDDNIRETKNAVIRDLGK--KITFSDVRPNQQEYKISSFEQRLMNEIEFRLE-RTPVDES 928
ND + T++ ++D GK ITF D+ I Q + + E + V E
Sbjct: 5659 NDQRLHTTRSVSMQDEGKTHSITFKDL-------SIDDTSQIRVEAMGMSSEAKLTVLEG 5711
Query: 929 DDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKR 988
D P F +L+ + E V C+I P V WFKDGK+I K
Sbjct: 5712 D---------------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEI-KP 5754
Query: 989 NEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ--GRISCSGHLMVQSLPIRSRLT 1046
+++ ++ +G L ++ D G YT + G++ + P+ S
Sbjct: 5755 SKNAVIKADGKKR-MLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEV 5813
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRL-------CRLD------ 1093
++ R + + E D + LQ P + EG++ CRLD
Sbjct: 5814 METETARFETEISEDDIH-ANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVD 5872
Query: 1094 ---------------CKVSGLPPP-----------------------ELTWLLNGQPVLP 1115
+V GL P + W L G+ + P
Sbjct: 5873 FQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEP 5932
Query: 1116 DASHKMLVRETG-VHSLLIDPLTQRDAGTYKCIATN-KTGQNSFSLELSVVAKEVKKAPV 1173
S K++ R G VH+L + + DAG + A + KT N F VK+ PV
Sbjct: 5933 --SDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----------VKEPPV 5980
Query: 1174 ILEK-LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL 1232
K L++ V EG LEC V V ++K E + + I L+
Sbjct: 5981 EFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRK---LV 6037
Query: 1233 IQPAKKSDAGWYTLSAKN 1250
I D YT AK+
Sbjct: 6038 IHDCTPEDIKTYTCDAKD 6055
Score = 48.5 bits (114), Expect = 4e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT KL+ E V L C + P V+W+ +GKE++ S + I G L +
Sbjct: 5713 PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRMLIL 5771
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+A + D G+Y+C GTD TS ++ IE
Sbjct: 5772 KKALKSDIGQYTCDC----GTDKTSGKLDIE 5798
Score = 48.5 bits (114), Expect = 4e-05
Identities = 54/231 (23%), Positives = 91/231 (39%), Gaps = 22/231 (9%)
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG- 360
W +G+ L +PD I + G +HSL + + TG A+N+ + + + G
Sbjct: 5834 WKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGL 5893
Query: 361 ------VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ 414
V+ + E E++ P E VP+++ V + ++
Sbjct: 5894 LRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVK 5953
Query: 415 QCQSPTNYLQGLDGKP-----IIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ L D K + PV FTK L++ + EG V EC V + KV+W
Sbjct: 5954 LEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEV-SRENAKVKW 6012
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASN 519
++ GT IL+ K + + LVI + ED +TC A +
Sbjct: 6013 FKNGT--------EILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 6055
Score = 48.5 bits (114), Expect = 4e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLEL--SVVAKEVKKAPVI---LEKLQNCGVPEG 1186
+I LTQ ++ A N G S E+ + + PVI LE + G
Sbjct: 20523 IISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAG 20582
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
V+L + G P P W KD++ + + ++TT A +LI+ A + ++G Y L
Sbjct: 20583 TSVKLRAGISGKPAPTIEWYKDDKELQTNA--LVCVENTTDLASILIKDADRLNSGCYEL 20640
Query: 1247 SAKNEAGIVSCTARLDI 1263
+N G S T R+ I
Sbjct: 20641 KLRNAMGSASATIRVQI 20657
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ G+ V V G P PK+EW + T+IE D LQ ++ E L I
Sbjct: 9103 IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD--ALQITKEEVSRSEAKTELSIP 9160
Query: 504 EVFAEDSGCFTCTASNKYGTV 524
+ ED G +T TASN+ G+V
Sbjct: 9161 KAVREDKGTYTVTASNRLGSV 9181
Score = 47.8 bits (112), Expect = 7e-05
Identities = 61/274 (22%), Positives = 105/274 (38%), Gaps = 66/274 (24%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVY----------------WFKDGKQISKRNEHCKMRREGD 999
+ EG+ V F ++ I VP+ Y W+ + ++ ++ R G
Sbjct: 2215 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGR 2274
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+L ++ T +D G Y+ + + +C L ++ PI
Sbjct: 2275 Q--NLTVKDVTKEDQGEYSFVIDGK--KTTCK--LKMKPRPIA----------------- 2311
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP-DAS 1118
LQ D EG + +L+ KVS L E W+ +GQ V P D
Sbjct: 2312 ---------------ILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRV 2355
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
H ++ +++ H LLI+ +T+ DAG Y +L LS + + ++ L
Sbjct: 2356 HIVIDKQS--HMLLIEDMTKEDAGNYSFTIP--------ALGLSTSGRVSVYSVDVITPL 2405
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
++ V EG LEC+V W ++E I
Sbjct: 2406 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI 2439
Score = 47.8 bits (112), Expect = 7e-05
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 34/286 (11%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
FT+ L + EV E ++L C V P +V WY +E+ + I+ G L I
Sbjct: 6160 FTKNLANIEVSETDTIKLVC-EVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQN 6218
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
A ED G Y+C + T ++ + +++ + P E+ +K V S
Sbjct: 6219 AHLEDAGNYNCRLPS----SRTDGKVKVHELAA-EFISKPQNLEILEGEKAEFVCSISKE 6273
Query: 391 SAVIP--------------PAVPQAQHLVAQPRVATIQQCQS---PTNYLQGLDGKPIIA 433
S + + + V + AT+Q + + +I
Sbjct: 6274 SFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE 6333
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
L++ E Q VVF C V K +W+R I DS + ILQK
Sbjct: 6334 KLRIVVPLKDTRVKEQQEVVFNCEVN-TEGAKAKWFRNEEAIFDSSKYIILQK------- 6385
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDL 538
+ + TL I + +D + + +N G V S A L V EDL
Sbjct: 6386 -DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE-EEDL 6429
Score = 47.4 bits (111), Expect = 9e-05
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 6/126 (4%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV--AKEVKKAPVILEKLQNCGVPEGH 1187
SL++ L + ++ A N G S E V AKE P IL Q + G
Sbjct: 12552 SLVVTGLKEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQLLPPKILMPEQ-ITIKAGK 12609
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLS 1247
+R+E V G P P WKK + + T +++H+ + + L+I+ + D+G+Y+L+
Sbjct: 12610 KLRIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSS-SILIIKDVTRKDSGYYSLT 12667
Query: 1248 AKNEAG 1253
A+N +G
Sbjct: 12668 AENSSG 12673
Score = 47.4 bits (111), Expect = 9e-05
Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 9/146 (6%)
Query: 900 QQEYKISSFEQRLMNEIEFR-LERTPVDESDDEIQHDEIPT-GKCIAPIFDKRLKH---F 954
Q+EY + E++ + +FR + RT V+ S D + + + P D +
Sbjct: 12943 QEEYTATGLEEKA--QYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLL 13000
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
V G+ V + G P+P V W KDG + K E KM + + C+L + S D
Sbjct: 13001 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLL-KPAEGIKMAMQRN-LCTLELFSVNRKDS 13058
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLP 1040
G+YTI A N G S + L V P
Sbjct: 13059 GDYTITAENSSGSKSATIKLKVLDKP 13084
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/137 (25%), Positives = 50/137 (36%), Gaps = 14/137 (10%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E L++ E R A + A D P + Y EP+ V E
Sbjct: 1762 EGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPV-------------RVLE 1808
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G + C V G P P+V WY G+ + S + G +H L I + DTG
Sbjct: 1809 GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IHYLDIVDCKSYDTGEVKVT 1867
Query: 343 ASNIYGTDSTSAEIYIE 359
A N G ++ I+
Sbjct: 1868 AENPEGVIEHKVKLEIQ 1884
Score = 46.6 bits (109), Expect = 2e-04
Identities = 39/134 (29%), Positives = 55/134 (41%), Gaps = 14/134 (10%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H LE +E + Q ++ SS + L P FT KL + E
Sbjct: 5323 HKLEMKEVTLDDISQIKAQV--------KELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 5374
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+ L C V P V+W+ +G+E+ SP I G L I +A +D G Y C
Sbjct: 5375 ITLKCEVSKDVP--VKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDC-- 5430
Query: 346 IYGTDSTSAEIYIE 359
GTD T A + +E
Sbjct: 5431 --GTDKTKANVTVE 5442
Score = 46.6 bits (109), Expect = 2e-04
Identities = 76/301 (25%), Positives = 114/301 (37%), Gaps = 58/301 (19%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLH 1005
F K L+ V EG+ C+ V KV WFK+G +I K K DG L
Sbjct: 5982 FTKPLEDQTVEEGATAVLECE-VSRENAKVKWFKNGTEILKSK---KYEIVADGRVRKLV 6037
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
I T +D YT A + + SC+ +++ P
Sbjct: 6038 IHDCTPEDIKTYTCDAKD--FKTSCNLNVV-----------------------------P 6066
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
F RP D+ E + R +C++S ++ W +G + + ++ +
Sbjct: 6067 PHVEFLRP-----LTDLQVREKEMARFECELS-RENAKVKWFKDGAEIKKGKKYD-IISK 6119
Query: 1126 TGVHSLLIDPLTQRDAGTYKC-IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V L+I+ D Y C + T +T S L+V+ +E V + L N V
Sbjct: 6120 GAVRILVINKCLLDDEAEYSCEVRTART-----SGMLTVLEEEA----VFTKNLANIEVS 6170
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG-YACLLIQPAKKSDAGW 1243
E ++L C V V ++K D E I R I T G L+IQ A DAG
Sbjct: 6171 ETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEIL----TEGRKRILVIQNAHLEDAGN 6226
Query: 1244 Y 1244
Y
Sbjct: 6227 Y 6227
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 8/97 (8%)
Query: 951 LKHF-RVTEGSPVTFTCKIVGIPVPKVYWFK------DGKQISKRNEHCKMRREGDGTCS 1003
LK F V EG+ V KI G+P P + WFK D K+ + H + D TC+
Sbjct: 9817 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN-KLVVDDTCT 9875
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L I + D G YTI A N G S L V P
Sbjct: 9876 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 9912
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ EG V ++KG P P + W++ D+ + +L + ++ CTLVI
Sbjct: 9821 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKE-PVLYDTHVNKLVVDDTCTLVIP 9879
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ D+G +T TA N GT S +L+V G
Sbjct: 9880 QSRRSDTGLYTITAVNNLGTASKEMRLNVLG 9910
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I LT + ++ A N+ G++ L + V+A++++ P + V +++
Sbjct: 19050 ISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKI 19109
Query: 1192 ECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ G P W+KD +T+ TR +S + T L I+ A K D G Y L N
Sbjct: 19110 DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS---LSIKEASKEDVGTYELCVSN 19166
Query: 1251 EAGIVS 1256
AG ++
Sbjct: 19167 SAGSIT 19172
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/97 (29%), Positives = 45/97 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP + LQ+ V EG E + G P P W +D + I + + G A
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
L I K+++G Y+L A N +G + TA L + A+
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE 100
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/98 (26%), Positives = 39/98 (39%), Gaps = 1/98 (1%)
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L P M +EG R C G P P +TWL GQ + A H++ + + I
Sbjct: 26259 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKY-KSTFEISS 26317
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV 1173
+ D G Y + N G+ L++ V + V
Sbjct: 26318 VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAV 26355
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/90 (28%), Positives = 42/90 (46%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P +K+ EV G + C + P + +W+ G+E+ S I + + SL I
Sbjct: 4529 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEI 4588
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
D G Y+C ASN YG+ S +A + +
Sbjct: 4589 LRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGR 338
V GT V+ I+ G+P P +W +G E++ + + + V+ N S LTI DTG
Sbjct: 11217 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIK-TDEHYTVETDNFSSVLTIKNCLRRDTGE 11275
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y SN G+ + + + +
Sbjct: 11276 YQITVSNAAGSKTVAVHLTV 11295
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P Q L ++V EG VQL+ + V + + W +G+E++ S +HIV H L
Sbjct: 2308 RPIAILQGLSDQKVCEGDIVQLE-VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2366
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I + +ED G YS F G STS + + V D N E + +VS
Sbjct: 2367 LIEDMTKEDAGNYS-FTIPALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSV 2424
Query: 387 PPTTS 391
P TS
Sbjct: 2425 PDVTS 2429
Score = 45.4 bits (106), Expect = 4e-04
Identities = 60/245 (24%), Positives = 86/245 (35%), Gaps = 15/245 (6%)
Query: 808 QPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKS 867
+P P P P ++ P P P +P AP + A+ T
Sbjct: 4669 KPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 4728
Query: 868 PQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYK--ISSFEQRLMNEIEFRLERTPV 925
P PV + + +GKK + + K I ++ + IE R
Sbjct: 4729 PPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAE-RRKLR 4787
Query: 926 DESDDEIQHDEIPTG---KCIAPIFDKRLKHFRVTE----GSPVTFTCKIVGIPVPKVYW 978
S E DE P K + F K +K +TE GS F C +V W
Sbjct: 4788 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFEC-LVSPSTAITTW 4846
Query: 979 FKDGKQISKRNEHCKMRREGDGTC-SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ 1037
KDG I + +H R DG LHI D G YT + + + L+V+
Sbjct: 4847 MKDGSNIRESPKH---RFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 4903
Query: 1038 SLPIR 1042
LP+R
Sbjct: 4904 ELPVR 4908
Score = 45.1 bits (105), Expect = 5e-04
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 3/122 (2%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I L Q + +++ A N+ G + L + V+AK++ P V G +++
Sbjct: 15803 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 15862
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ IG P P W KDN +P + + T + L I+ A + D G Y + N
Sbjct: 15863 DVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNS 15920
Query: 1252 AG 1253
AG
Sbjct: 15921 AG 15922
Score = 45.1 bits (105), Expect = 5e-04
Identities = 22/80 (27%), Positives = 43/80 (53%)
Query: 277 SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT 336
S V G ++++ + G P P + W +G L+ + I++ + +L +L+I E ++D
Sbjct: 16933 SYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDG 16992
Query: 337 GRYSCFASNIYGTDSTSAEI 356
G+Y +N+ G + S EI
Sbjct: 16993 GQYGITVANVVGQKTASIEI 17012
Score = 45.1 bits (105), Expect = 5e-04
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E +R E A AAG + P S + ++ + + PR + + R+ V G +L
Sbjct: 17282 EDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEV-ELPRISMDPKFRDTIVVNAGETFRL 17340
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ V G P P + W KE+E S I L + +A D G+Y ASN+ G
Sbjct: 17341 EADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 17400
Query: 349 TDSTSAEIYI 358
+ S + +
Sbjct: 17401 SKSFPVNVKV 17410
Score = 44.7 bits (104), Expect = 6e-04
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 2/110 (1%)
Query: 931 EIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE 990
EI + + P D V EG ++ +PVP V W KDGK++ K ++
Sbjct: 8068 EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV-KASD 8126
Query: 991 HCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
M+ + + L + + D G YTI N G + S ++ V LP
Sbjct: 8127 RLTMKND-HISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP 8175
Score = 44.7 bits (104), Expect = 6e-04
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K ++ V G+ V F I G+PVP W DG +I K +EH + + + L I++
Sbjct: 11210 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI-KTDEHYTVETDNFSSV-LTIKN 11267
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y I +N G + + HL V +P
Sbjct: 11268 CLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 11299
Score = 44.3 bits (103), Expect = 8e-04
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSLT 327
P F K S + EG + D VVG P P+ W+ +G+++ N +V + SL
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
I A D+G ++ A N G S S + +E V
Sbjct: 1471 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1504
Score = 44.3 bits (103), Expect = 8e-04
Identities = 34/136 (25%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 1144 YKCIATNKTG-----QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
++ A N+TG + + S++ + + E AP I +++++ G +L C+++G
Sbjct: 24198 FRVFAENETGLSRPRRTAMSIKTKLTSGE---APGIRKEMKDVTTKLGEAAQLSCQIVGR 24254
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W + + + +R + M D + L + ++ D G YT A NE G V +
Sbjct: 24255 PLPDIKWYRFGKELIQSR-KYKMSSDGRTHT-LTVMTEEQEDEGVYTCIATNEVGEVETS 24312
Query: 1259 ARLDIYA--QWHHQIP 1272
++L + A Q+H P
Sbjct: 24313 SKLLLQATPQFHPGYP 24328
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/201 (21%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
V W + KE++ S I G ++ LT+ ++D G+Y+ +A G + TS ++ +
Sbjct: 2517 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYA----GENMTSGKLTVA 2572
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSP-------------PTTSAVIPPAVPQAQHL-V 405
G + S D E EV++P P T+ + + + L +
Sbjct: 2573 GGAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 2632
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
A ++ I + K + A K L+NL+ +E Q VF +
Sbjct: 2633 AATKLDDIGEYTYKV-ATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKG 2691
Query: 466 VEWYREGTLIEDSPDFRILQK 486
V+W + G ++E + + I K
Sbjct: 2692 VQWIKNGVVLESNEKYAISVK 2712
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/288 (20%), Positives = 109/288 (37%), Gaps = 39/288 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F L +V E + +C V P RW +E+ +++ G HS+
Sbjct: 5534 PLIFITPLSDVKVFEKDEAKFEC-EVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMV 5592
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-----------VSSSDSEGDPNKEEMN 376
I A ED +Y A + + TS ++ IEG V++ + E E++
Sbjct: 5593 IKSAAFEDEAKYMFEAEDKH----TSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELS 5648
Query: 377 ----RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPII 432
R++ TT +V + + + +I G+ + +
Sbjct: 5649 HDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKD--LSIDDTSQIRVEAMGMSSEAKL 5706
Query: 433 AA----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
P FT LQ+ + E V+ +C + A +P V+W+++G I+ S + I
Sbjct: 5707 TVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGK 5765
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ M L++ + D G +TC GT + +L + E
Sbjct: 5766 KRM--------LILKKALKSDIGQYTCDC----GTDKTSGKLDIEDRE 5801
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 31/258 (12%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V G DC + P V WY +GK+LE S + G +H+LT+ + E
Sbjct: 5897 LKDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 5955
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIE--GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSA 392
D G A + T A ++++ V + D EE EVS
Sbjct: 5956 DAGEVQLTAKDF----KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 6011
Query: 393 VIPPAV----PQAQHLVAQPRV--ATIQQCQSPTNYLQGLDGKPI-------IAAP--VF 437
+ +VA RV I C D K + P F
Sbjct: 6012 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEF 6071
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
+ L +L E ++ FEC + + KV+W+++G I+ + I+ K +
Sbjct: 6072 LRPLTDLQVREKEMARFECEL-SRENAKVKWFKDGAEIKKGKKYDIISK--------GAV 6122
Query: 498 CTLVIAEVFAEDSGCFTC 515
LVI + +D ++C
Sbjct: 6123 RILVINKCLLDDEAEYSC 6140
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 5/121 (4%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +T+ ++ R GT V+L + G P P + WY + KEL+ + + + +L S+
Sbjct: 20570 PLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL 20626
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I +A ++G Y N G S SA I ++ + G P + + +K + P
Sbjct: 20627 IKDADRLNSGCYELKLRNAMG--SASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRP 20684
Query: 388 P 388
P
Sbjct: 20685 P 20685
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYK 1145
G RL VSG PPP +TW G D + + ++ T +SLLI D + + DAG Y
Sbjct: 23156 GASLRLMVSVSGRPPPVITWSKQG----IDLASRAIIDTTESYSLLIVDKVNRYDAGKYT 23211
Query: 1146 CIATNKTGQNSFSLELSV 1163
A N++G+ S ++ + V
Sbjct: 23212 IEAENQSGKKSATVLVKV 23229
Score = 43.1 bits (100), Expect = 0.002
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVILEKLQ---NCGVPEGH 1187
+ LT+ A ++ IA N G S E S + ++ +AP I ++ + G
Sbjct: 15113 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 15172
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G PPP W KD + + T + I + +T L+ + + + D+G YTL
Sbjct: 15173 AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN---LVNKDSTRRDSGAYTL 15229
Query: 1247 SAKNEAG 1253
+A N G
Sbjct: 15230 TATNPGG 15236
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 3/103 (2%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
A G +P S PS + P+ ++ ++ + G +L+ V G PPP + W
Sbjct: 15131 AAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEW 15190
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+GKELE + + I A +L ++ D+G Y+ A+N
Sbjct: 15191 SKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATN 15233
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/211 (22%), Positives = 78/211 (36%), Gaps = 18/211 (8%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V EGT+ L+C V V+WY ++++ + + G L I
Sbjct: 2405 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHAS 2464
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPT----- 389
D G Y I G T+ + +E + D E + E+S
Sbjct: 2465 DEGPYKL----IVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520
Query: 390 -TSAVIPPAVP---QAQHLVAQPRVAT-IQQCQSPTNYLQG---LDGKPIIAAPVFTKML 441
I P+ +A + + V ++ + + G GK +A +K L
Sbjct: 2521 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPL 2580
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
+ + +E Q VFEC V P K EW R+G
Sbjct: 2581 TDQTVAESQEAVFECEVAN-PDSKGEWLRDG 2610
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD- 1140
+V H G + R+ VSG PPP +TW +N + + +A+ + T + S ++ QR
Sbjct: 10229 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEAT----IETTAISSSMVIKNCQRSH 10284
Query: 1141 AGTYKCIATNKTGQNSFSLELSVV 1164
G Y +A N+ G+ ++ + V+
Sbjct: 10285 QGVYSLLAKNEAGERKKTIIVDVL 10308
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 8/125 (6%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCG----VPEGHPVRLECRVIGM 1198
++ A N G+ L SV+AK++ P + E C V G +R+ RV G
Sbjct: 11572 FRIKAANIVGEGEPRELAESVIAKDILHPPEV-ELDVTCRDVITVRVGQTIRILARVKGR 11630
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W K+ + + +R+ + QD L I+ A ++D G Y +SAKN +G +
Sbjct: 11631 PEPDITWTKEGKVL-VREKRVDLIQDLPRVE-LQIKEAVRADHGKYIISAKNSSGHAQGS 11688
Query: 1259 ARLDI 1263
A +++
Sbjct: 11689 AIVNV 11693
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/90 (21%), Positives = 44/90 (48%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P + + G ++++ V+G P P + W +G+ L+ + +++ + L I
Sbjct: 18007 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 18066
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
E ++D G+Y+ A+N GT + + + +
Sbjct: 18067 KEGNKDDFGKYTVTATNSAGTATENLSVIV 18096
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 248 GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVP--EGTRVQLDCIVVGIPPPQVRWYCE 305
G + P + SS+ +EP +P + ++ + G+ +D + G P P+V W E
Sbjct: 22320 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22379
Query: 306 GKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
L+ + + I + +LT+ ++ D+GRY N G + S + + G
Sbjct: 22380 EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 22434
Score = 42.0 bits (97), Expect = 0.004
Identities = 42/181 (23%), Positives = 75/181 (41%), Gaps = 11/181 (6%)
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
TW+ +G + H+ + +ID + DAG Y C+ + + + +L V
Sbjct: 4845 TWMKDGSNIRESPKHRFIADGKDRKLHIID-VQLSDAGEYTCVLRLGNKEKTSTAKLVVE 4903
Query: 1165 AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
V+ + E++ V +G P+ L C + V W+KD + + RI
Sbjct: 4904 ELPVRFVKTLEEEVT---VVKGQPLYLSCELNKERDVV--WRKDGKIVVEKPGRIV--PG 4956
Query: 1225 TTGYA-CLLIQPAKKSDAGWYTLSAKNEAGI--VSCTARLDIYAQWHHQIPPPMSVRPSG 1281
G L I A +DAG YT++ +N + SC +++ W + V+P G
Sbjct: 4957 VIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKG 5016
Query: 1282 S 1282
+
Sbjct: 5017 T 5017
Score = 42.0 bits (97), Expect = 0.004
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 16/165 (9%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E + E A AG + P S ++ ++ P P L + G +
Sbjct: 14035 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLT---IKAGDTI 14091
Query: 287 QLDCI-VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ I ++G P P+ W GK++ S I LTI A +D G Y+ A+N
Sbjct: 14092 VLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATN 14151
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI--QKPNEVSSPP 388
+GT ++ + D G P E++ + +K +PP
Sbjct: 14152 PFGTKVEHVKVTV-----LDVPGPPGPVEISNVSAEKATLTWTPP 14191
Score = 42.0 bits (97), Expect = 0.004
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 2/84 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + G + ++G P P + W KDG+ + K+ + T
Sbjct: 18005 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPL-KQTTRVNVEETATSTV 18063
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
LHI+ DD G YT+ A N G
Sbjct: 18064 -LHIKEGNKDDFGKYTVTATNSAG 18086
Score = 41.6 bits (96), Expect = 0.005
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V G V L+ V G P P WKKD + P +++M ++ L + + D+
Sbjct: 13002 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CTLELFSVNRKDS 13058
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
G YT++A+N +G S T +L + + PP SV+
Sbjct: 13059 GDYTITAENSSGSKSATIKLKVL----DKPGPPASVK 13091
Score = 41.6 bits (96), Expect = 0.005
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
LD V G P P ++W +G + P KM + + + +L + + ++D+G Y A N
Sbjct: 13010 LDATVFGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENS 13068
Query: 1152 TGQNSFSLELSVVAKEVKKAPVILEKL 1178
+G S +++L V+ K A V + K+
Sbjct: 13069 SGSKSATIKLKVLDKPGPPASVKINKM 13095
Score = 41.2 bits (95), Expect = 0.007
Identities = 74/335 (22%), Positives = 131/335 (39%), Gaps = 58/335 (17%)
Query: 922 RTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
R P +D +++ E+ A F + ++ + EG F C I P V W +D
Sbjct: 6230 RLPSSRTDGKVKVHEL------AAEFISKPQNLEILEGEKAEFVCSISKESFP-VQWKRD 6282
Query: 982 GKQISKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHL-MVQSL 1039
K + +++ + DG L ++ T D G Y +M G + HL +++ L
Sbjct: 6283 DKTLESGDKYDVI---ADGKKRVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKL 6335
Query: 1040 PIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGL 1099
I L +RV+E+ QE F +C+V+
Sbjct: 6336 RIVVPLKD--------TRVKEQ-----QEVVF---------------------NCEVN-T 6360
Query: 1100 PPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL 1159
+ W N + + D+S +++++ V++L I D Y TN G+N S
Sbjct: 6361 EGAKAKWFRNEEAIF-DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 6419
Query: 1160 ELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+V +E + I+E L++ E V C+V + W K+ E +P R+
Sbjct: 6420 ANLIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGEEVPFD-NRV 6474
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
S D + L I+ D G Y ++A + +
Sbjct: 6475 SYRVDKYKH-MLTIKDCGFPDEGEYIVTAGQDKSV 6508
Score = 41.2 bits (95), Expect = 0.007
Identities = 29/102 (28%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
+VVAK+ P I + + V EG + + +P P W KD + + + +R++M
Sbjct: 8072 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKAS-DRLTM 8130
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
D A L + + ++DAG YT++ +N+ G S TA +++
Sbjct: 8131 KNDHIS-AHLEVPKSVRADAGIYTITLENKLG--SATASINV 8169
Score = 40.8 bits (94), Expect = 0.009
Identities = 22/79 (27%), Positives = 36/79 (45%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V GT+++L V G P P++ W L+ I I ++TI ++ DTG Y
Sbjct: 7397 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 7456
Query: 340 SCFASNIYGTDSTSAEIYI 358
A N+ G + E+ +
Sbjct: 7457 IIEAVNVCGRATAVVEVNV 7475
Score = 40.8 bits (94), Expect = 0.009
Identities = 31/136 (22%), Positives = 59/136 (43%), Gaps = 5/136 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
++ L + ++ A N G + S + + P ++ + V EG V +
Sbjct: 9773 VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIV 9832
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQP-AKKSDAGWYTLS 1247
++ G+P P W K P +E + +++ C L+ P +++SD G YT++
Sbjct: 9833 AKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT 9892
Query: 1248 AKNEAGIVSCTARLDI 1263
A N G S RL++
Sbjct: 9893 AVNNLGTASKEMRLNV 9908
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +R+ V G PPP W + T+P + + + T + ++I+ ++S G
Sbjct: 10231 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLP----QEATIETTAISSSMVIKNCQRSHQG 10286
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
Y+L AKNEAG T +D+
Sbjct: 10287 VYSLLAKNEAGERKKTIIVDV 10307
Score = 40.8 bits (94), Expect = 0.009
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 9/126 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E +R E A AAG + P S ++ + + P P++ + V G
Sbjct: 18364 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVI---VVHAGETF 18420
Query: 287 QLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ + G P P V W +GKEL E + + I +L + + D G+Y SN
Sbjct: 18421 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 18480
Query: 346 IYGTDS 351
+ GT S
Sbjct: 18481 VGGTKS 18486
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGN 322
+P + P T +++RE ++++D G P V W +G+ L+ + +++ +
Sbjct: 19089 KPSVELPFHTFNVKARE-----QLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT 19143
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ SL+I EA +ED G Y SN G+ + I +
Sbjct: 19144 VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIV 19179
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGHPVR 1190
L+ D ++ IA N G S + S ++ ++ P++ E + G +R
Sbjct: 21613 LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLR 21672
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMH-QDTTGYACLLIQPAKKSDAGWYTLSAK 1249
++ V G P P W KD I +R++M D G L ++ A + G YT+ AK
Sbjct: 21673 IKALVQGRPVPRVTWFKDGVEI---EKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAK 21729
Query: 1250 NEAGIVSCTARLDI 1263
N +G ++ +
Sbjct: 21730 NASGSAKAEIKVKV 21743
Score = 40.8 bits (94), Expect = 0.009
Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
+ G +++ +V G P P+V W+ +G E+E ++ I SL + +A + G Y
Sbjct: 21665 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 21724
Query: 340 SCFASNIYGTDSTSAEIYIE 359
+ A N G S AEI ++
Sbjct: 21725 TVEAKNASG--SAKAEIKVK 21742
Score = 40.4 bits (93), Expect = 0.011
Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 26/236 (11%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV--RWYCEGKELENSPDIHIVQAGNL 323
G F ++L+ EVPE +L+CIV P + +WY EL+++ I
Sbjct: 2218 GAVVEFVKELQDIEVPESYSGELECIV---SPENIEGKWYHNDVELKSNGKYTITSRRGR 2274
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAE----IYIEGVSSSD-SEGDPNKEEMN-- 376
+LT+ + +ED G YS T + ++G+S EGD + E+
Sbjct: 2275 QNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVS 2334
Query: 377 -------RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--D 427
++ EV VI Q+ L+ + S T GL
Sbjct: 2335 LESVEGVWMKDGQEVQPSDRVHIVID---KQSHMLLIEDMTKEDAGNYSFTIPALGLSTS 2391
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
G+ + + L++++ EG V EC+V V+WY I+ PD R+
Sbjct: 2392 GRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIK--PDDRV 2445
Score = 40.4 bits (93), Expect = 0.011
Identities = 24/97 (24%), Positives = 40/97 (41%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + EG +T C G P P+V W G++I + + D
Sbjct: 27022 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 27081
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
+L I D G YT+ N G S + ++ ++S+
Sbjct: 27082 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 27118
Score = 40.0 bits (92), Expect = 0.015
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 10/93 (10%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLL-------NGQPVLPDAS-HKMLVRETGVHSLLI 1133
M EG + K+ G+P P LTW N +PVL D +K++V +T +L+I
Sbjct: 9821 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVI 9878
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
+ D G Y A N G S + L+V+ +
Sbjct: 9879 PQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 9911
Score = 40.0 bits (92), Expect = 0.015
Identities = 34/140 (24%), Positives = 61/140 (43%), Gaps = 8/140 (5%)
Query: 231 QEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+E K+ + AA A G + P + +E L PP+ + G +++++
Sbjct: 12559 KEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQL-LPPKILMP-EQITIKAGKKLRIEA 12615
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
V G P P +W E+ S + + +A + L I + +D+G YS A N GTD
Sbjct: 12616 HVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD 12675
Query: 351 STSAEIYIEGVSSSDSEGDP 370
+ ++ + D+ G P
Sbjct: 12676 TQKIKVVV-----MDAPGPP 12690
Score = 40.0 bits (92), Expect = 0.015
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
++ G RL+ VSG PPP + W +G+ + A ++ + + +L+ T+RD+
Sbjct: 15166 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDS 15224
Query: 1142 GTYKCIATNKTG 1153
G Y ATN G
Sbjct: 15225 GAYTLTATNPGG 15236
Score = 40.0 bits (92), Expect = 0.015
Identities = 23/81 (28%), Positives = 36/81 (44%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F + V G +++D +G P P V W+ + L+ + ++ N LT
Sbjct: 15842 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 15901
Query: 328 IAEAFEEDTGRYSCFASNIYG 348
I +A ED G Y +N G
Sbjct: 15902 IKDACREDVGHYVVKLTNSAG 15922
Score = 39.7 bits (91), Expect = 0.019
Identities = 40/179 (22%), Positives = 72/179 (40%), Gaps = 11/179 (6%)
Query: 184 KLESQNKVMQENSSSFSDLSERRERSSVPIP---IPADTRDNEVNHALEQQEAKRREAEQ 240
++ES+ + E S F+ S + + P+ A D + + +L+ E K + +
Sbjct: 4352 EVESKYLISTEEVSYFNVQSRVKYLDATPVTKGVASAVVSDEKQDESLKPSEEKEESSSE 4411
Query: 241 AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV 300
+ +E + + + P+ P L EG V L + +V
Sbjct: 4412 SGTEEVATVKIQEAEGGLIKEDGPMIHTP-----LVDTVSEEGDIVHLTTSITNAK--EV 4464
Query: 301 RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEED-TGRYSCFASNIYGTDSTSAEIYI 358
WY E K + + +Q N ++L I + ED G Y C A N G +TSA++ +
Sbjct: 4465 NWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTV 4523
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 10/121 (8%)
Query: 1139 RDAGTYK--CIATNKTGQNSFS-LELSVVAKEVKKAPVIL---EKLQNCGVPEGHPVRLE 1192
RD TYK +A N G++ + + V+ K+ + P ++ + + G +RL
Sbjct: 10875 RDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLS 10934
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ G+P P WKK++ P T+ RI + T + L I+ A D G Y+L+ +N A
Sbjct: 10935 AIIKGVPFPKVTWKKEDRDAP-TKARIDV---TPVGSKLEIRNAAHEDGGIYSLTVENPA 10990
Query: 1253 G 1253
G
Sbjct: 10991 G 10991
Score = 39.7 bits (91), Expect = 0.019
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
+E+ P L P + G+ R++ V G P P W G+ + +SH + +
Sbjct: 12589 KEQLLPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKAD 12646
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
L+I +T++D+G Y A N +G ++ +++ V+
Sbjct: 12647 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVM 12684
Score = 39.7 bits (91), Expect = 0.019
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
VP G PV L + G PPP W + ER+++ + T A L I+ D G
Sbjct: 23445 VPAGRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTG 23502
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
YTL KN G S T ++ I
Sbjct: 23503 EYTLELKNVTGTTSETIKVII 23523
Score = 39.7 bits (91), Expect = 0.019
Identities = 68/316 (21%), Positives = 110/316 (34%), Gaps = 54/316 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG-DGTC 1002
AP R++ RV G F + P +V W+ +G ++ E K+ G
Sbjct: 26068 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ---ESSKIHYTNTSGVL 26124
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I +DD G Y + N +G S L V + + Q RD
Sbjct: 26125 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYAS------------QRRD 26172
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
+E + F P + V+ + ++ S
Sbjct: 26173 EEVPRSVF--PELTRTEAYAVSSFKKTSEMEASSS------------------------- 26205
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ-NSFSLELSVVAKEVKK--APVILEKLQ 1179
VRE V S + + + + A K+ SLE +++K A IL K +
Sbjct: 26206 VRE--VKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR 26263
Query: 1180 NCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG--YACLLIQPAK 1237
+ V EG R C G P P W + + + + + HQ TT + I +
Sbjct: 26264 SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS----ARHQVTTTKYKSTFEISSVQ 26319
Query: 1238 KSDAGWYTLSAKNEAG 1253
SD G Y++ +N G
Sbjct: 26320 ASDEGNYSVVVENSEG 26335
Score = 39.3 bits (90), Expect = 0.025
Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 11/127 (8%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSR---EVPEGTRVQLDCI 291
R A AA E G+T P + EP +PP + + ++ G +++ +
Sbjct: 8770 RVSAVNAAGEGPPGETQP------VTVAEPQ-EPPAVELDVSVKGGIQIMAGKTLRIPAV 8822
Query: 292 VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDS 351
V G P P W E EL+ + I G L I +A +D GRY A+N G+
Sbjct: 8823 VTGRPVPTKVWTKEEGELDKDRVV-IDNVGTKSELIIKDALRKDHGRYVITATNSCGSKF 8881
Query: 352 TSAEIYI 358
+A + +
Sbjct: 8882 AAARVEV 8888
Score = 38.9 bits (89), Expect = 0.033
Identities = 62/298 (20%), Positives = 114/298 (38%), Gaps = 61/298 (20%)
Query: 951 LKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
LK V EG+ CK+ V V W+ + +QI K ++ + +G L I T
Sbjct: 2405 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI-KPDDRVQAIVKGTKQ-RLVINRTH 2462
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
+ D+G Y ++ GR+ + +L V+ + I
Sbjct: 2463 ASDEGPYKLIV----GRVETNCNLSVEKIKI----------------------------- 2489
Query: 1071 FRPHFLQAPGDMVAHEGR--LCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ D+ E + + ++ SG+ ++ W + + P + +K + +
Sbjct: 2490 -----IRGLRDLTCTETQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYK-IEAHGKI 2540
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
+ L + + + D G Y T G+N S +L+V + K L + V E
Sbjct: 2541 YKLTVLNMMKDDEGKY----TFYAGENMTSGKLTVAGGAISK------PLTDQTVAESQE 2590
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY-ACLLIQPAKKSDAGWYT 1245
EC V P W +D + +P T ++ ++ G+ L+I K D G YT
Sbjct: 2591 AVFECEVAN-PDSKGEWLRDGKHLPLTN---NIRSESDGHKRRLIIAATKLDDIGEYT 2644
Score = 38.9 bits (89), Expect = 0.033
Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 40/222 (18%)
Query: 814 PIPVSPTSRIQNPVAFLSSVLPSLPAIPP---------TNAMGLPRSAPSMPSQGLAKKN 864
P SP R ++PV LPS P+ P T A P P G +
Sbjct: 19763 PSETSPLIRAEDPV-----FLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEY 19817
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTP 924
KS DD +T +R G + T S + + F + +N++ P
Sbjct: 19818 KKS-----DDTDWKTSIQSLR--GTEYTISGLTTGAEYV----FRVKSVNKVG---ASDP 19863
Query: 925 VDESDDEIQHDEIPTGKCIAPIFD---KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
D SD +I + P+FD + K V G+ T T G PVP V W K
Sbjct: 19864 SDSSDPQIAKEREEE-----PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKP 19918
Query: 982 GKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAAN 1023
+ R D SL IE+ +D G YT+ N
Sbjct: 19919 DTDLRTR----AYVDTTDSRTSLTIENANRNDSGKYTLTIQN 19956
Score = 38.9 bits (89), Expect = 0.033
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 5/80 (6%)
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS-LLIDPLTQRDAGTY 1144
+G + RL + G P P W GQ D S + ++ + H+ L+I + D+GTY
Sbjct: 23845 QGGVIRLTIPIKGKPFPICKWTKEGQ----DISKRAMIATSETHTELVIKEADRGDSGTY 23900
Query: 1145 KCIATNKTGQNSFSLELSVV 1164
+ NK G+ + +++ V+
Sbjct: 23901 DLVLENKCGKKAVYIKVRVI 23920
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 8/114 (7%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT +Q +D + + K+L L+ G + V G P PK+ W +
Sbjct: 7370 PTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTK-------- 7421
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
D + Q K ++ + T+ I + D+G + A N G +++ +++V
Sbjct: 7422 ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7475
Score = 38.5 bits (88), Expect = 0.043
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +RL G P P W K + + R +H T ++ L ++ ++DAG
Sbjct: 22064 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL---RADIHT-TDSFSTLTVENCNRNDAG 22119
Query: 1243 WYTLSAKNEAGIVSCT 1258
YTL+ +N +G S T
Sbjct: 22120 KYTLTVENNSGSKSIT 22135
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 5/96 (5%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G+ + LD V G P P++ W KEL+ + + G + I D+G+Y+
Sbjct: 22757 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLT 22816
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
N GT + S + + DS G K ++R+
Sbjct: 22817 VKNASGTKAVSVMVKV-----LDSPGPCGKLTVSRV 22847
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/154 (21%), Positives = 71/154 (46%), Gaps = 16/154 (10%)
Query: 1144 YKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKL--QNCGVPE-GHPVRLECRVIGMP 1199
++ A N+ G++ S + A ++++ P + + Q+C V + G +R+ + G P
Sbjct: 9474 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 9533
Query: 1200 PPVFYWKKDNETIPCTRERI------SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
P W+ D + ++ + + + + ++I K+S G Y+++AKN+AG
Sbjct: 9534 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 9593
Query: 1254 IVSCTARLDIYAQWHHQIP-PPMSVRPSGSRYGS 1286
+ R+ + +P PP ++ S GS
Sbjct: 9594 QKTANCRVKVM-----DVPGPPKDLKVSDITRGS 9622
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 9/122 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWY-C 304
A G + P ++ + P PP K EV EGT V + + G+P P + W+
Sbjct: 9791 AAGVSKPSATVGPCDCQRP-DMPPSIDLK-EFMEVEEGTNVNIVAKIKGVPFPTLTWFKA 9848
Query: 305 EGKELENSP----DIHI--VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
K+ +N D H+ + + +L I ++ DTG Y+ A N GT S + +
Sbjct: 9849 PPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9908
Query: 359 EG 360
G
Sbjct: 9909 LG 9910
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/142 (23%), Positives = 65/142 (45%), Gaps = 10/142 (7%)
Query: 1121 MLVRETGVH--SLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVI--- 1174
M TG++ ++ ++ L ++ ++ A NK G + + ++ +E +AP I
Sbjct: 16581 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 16640
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
LE + + G +RL + G P P W K + I ++ T+ + L++
Sbjct: 16641 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI----RDAAIIDVTSSFTSLVLD 16696
Query: 1235 PAKKSDAGWYTLSAKNEAGIVS 1256
+ D+G YTL+ +N +G S
Sbjct: 16697 NVNRYDSGKYTLTLENSSGTKS 16718
Score = 38.1 bits (87), Expect = 0.056
Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 24/126 (19%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRD 1140
+V + G RL+ V G P P + WL + + + S + ++ T +LLI + D
Sbjct: 17330 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEI--EESARCEIKNTDFKALLIVKDAIRID 17387
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL------ECR 1194
G Y A+N G SF PV ++ L G PEG PV++ +C
Sbjct: 17388 GGQYILRASNVAGSKSF--------------PVNVKVLDRPGPPEG-PVQVTGVTSEKCS 17432
Query: 1195 VIGMPP 1200
+ PP
Sbjct: 17433 LTWSPP 17438
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
GR L ++G PPP +W G L ++ + T V L I T RD G Y
Sbjct: 23448 GRPVELVIPIAGRPPPAASWFFAGSK-LRESERVTVETHTKVAKLTIRETTIRDTGEYTL 23506
Query: 1147 IATNKTGQNSFSLELSVVAK 1166
N TG S ++++ ++ K
Sbjct: 23507 ELKNVTGTTSETIKVIILDK 23526
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 448 EGQLVVFECRVKGAP-SPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG V + C+++ S +V WY +E+S + I + + + L + ++
Sbjct: 25276 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYE--------DGVAILYVKDIT 25327
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHVRG 534
D G + C N YG SS A+L V+G
Sbjct: 25328 KLDDGTYRCKVVNDYGEDSSYAELFVKG 25355
Score = 37.7 bits (86), Expect = 0.073
Identities = 60/224 (26%), Positives = 88/224 (39%), Gaps = 25/224 (11%)
Query: 157 FIEELSSLFK-SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPI 215
F E L+ L K S SS I+ AC+ K N +++ S +DL + S PI
Sbjct: 11473 FAENLAGLSKPSPSSDPIK--ACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPI 11530
Query: 216 ---------PADTRDNEVNH-ALEQQEAKRREAEQAASE------AAG--GDTTPGSSPS 257
P + N +N L +Q A R +E AA G+ P
Sbjct: 11531 LGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAE 11590
Query: 258 SLYYEEPLGQPPRFTQKLRSREVPE---GTRVQLDCIVVGIPPPQVRWYCEGKELENSPD 314
S+ ++ L PP + R+V G +++ V G P P + W EGK L
Sbjct: 11591 SVIAKDIL-HPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKR 11649
Query: 315 IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ ++Q L I EA D G+Y A N G SA + +
Sbjct: 11650 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 11693
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 8/84 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
GQ + RVKG P P + W +EG ++ ++Q PR L I E
Sbjct: 11618 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPR--------VELQIKEAVRA 11669
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
D G + +A N G A ++V
Sbjct: 11670 DHGKYIISAKNSSGHAQGSAIVNV 11693
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ +++ +SG P P +TW +G P L + + + +L I + D G Y
Sbjct: 16939 GQDLKIEVPISGRPKPTITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16997
Query: 1147 IATNKTGQNSFSLELSVVAK-EVKKAPV 1173
N GQ + S+E+ + K + K PV
Sbjct: 16998 TVANVVGQKTASIEIVTLDKPDPPKGPV 17025
Score = 37.4 bits (85), Expect = 0.096
Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 4/93 (4%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYAC 1230
P+ ++++ N + G L VIG+P P W + + P + D
Sbjct: 3649 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHS--- 3705
Query: 1231 LLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L+I K D G YT A N+ G C+A L I
Sbjct: 3706 LIILFTKLEDEGEYTCMASNDYGKTICSAYLKI 3738
Score = 37.4 bits (85), Expect = 0.096
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 17/164 (10%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W+ ++P+ ++K+ E G L Y+ A NK G + S L +
Sbjct: 7033 WIRCNMKLVPELTYKVTGLEKGNKYL------------YRVSAENKAGVSDPSEILGPLT 7080
Query: 1166 KE---VKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+ V+ + V +P+ + G P P W ++ + T +R+ M
Sbjct: 7081 ADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLE-TGDRVKM- 7138
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ + YA L+I P+++SD G YTL +N +S +++ A+
Sbjct: 7139 KTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR 7182
Score = 37.4 bits (85), Expect = 0.096
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDAGWY 1244
G +RL V G PPP W K N + R+RI + +T + L + K DAG Y
Sbjct: 13403 GVTMRLYVPVKGRPPPKITWSKPNVNL---RDRIGLDIKSTDFDTFLRCENVNKYDAGKY 13459
Query: 1245 TLSAKNEAG 1253
L+ +N G
Sbjct: 13460 ILTLENSCG 13468
Score = 37.4 bits (85), Expect = 0.096
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVI-LEKLQNCGV--PEGHPVRLECRVIGMP 1199
++ A N GQ + V AK++ +AP I L+ V G V++ G P
Sbjct: 20935 FRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRP 20994
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
PP W+KD + + + R S+ ++T + L I ++D G Y L+ +N G
Sbjct: 20995 PPTVTWRKDEKNLG-SDARYSI-ENTDSSSLLTIPQVTRNDTGKYILTIENGVG 21046
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 21/140 (15%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEP-----LGQPPRFTQKLRSREVPEGTRVQLD 289
R +A A E+ DTT G P++ EEP +G K G+++++
Sbjct: 9475 RVKAVNEAGESEPSDTT-GEIPATDIQEEPEVFIDIGAQDCLVCKA-------GSQIRIP 9526
Query: 290 CIVVGIPPPQVRWYCEGKE-------LENSP-DIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
++ G P P+ W +GK + + P D + A N + I E TG+YS
Sbjct: 9527 AVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSI 9586
Query: 342 FASNIYGTDSTSAEIYIEGV 361
A N G + + + + V
Sbjct: 9587 TAKNKAGQKTANCRVKVMDV 9606
Score = 37.0 bits (84), Expect = 0.13
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + V G + I G P P + W KDG + K+ + D T
Sbjct: 16923 IEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL-KQTTRINVTDSLDLT- 16980
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+L I+ T DD G Y I AN G+ + S ++ P
Sbjct: 16981 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 17018
Score = 37.0 bits (84), Expect = 0.13
Identities = 45/176 (25%), Positives = 76/176 (43%), Gaps = 12/176 (6%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP-LTQRD 1140
++A G ++ G PPP +TW + + + DA + + T SLL P +T+ D
Sbjct: 20976 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYS--IENTDSSSLLTIPQVTRND 21033
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL--ECRVIGM 1198
G Y N G+ + S V+ +V P +KLQ V G L + G
Sbjct: 21034 TGKYILTIENGVGEP----KSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGG 21089
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
P + Y + + T +S +T + LI ++K+ ++ + A+NE GI
Sbjct: 21090 SPIINYVIEKRDATKRTWSVVSHKCSSTSFK--LIDLSEKTPF-FFRVLAENEIGI 21142
Score = 36.6 bits (83), Expect = 0.16
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 3/85 (3%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G P+ + G P PKV W K G R + D L I ++T DD G
Sbjct: 12313 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLV---DTMAFLVIPNSTRDDSG 12369
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y++ NP G + ++ V P
Sbjct: 12370 KYSLTLVNPAGEKAVFVNVRVLDTP 12394
Score = 36.6 bits (83), Expect = 0.16
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G +++ V G P P ++W+ +G+P+ + ++ V ET ++L I + D G Y
Sbjct: 18021 GEDLKIEIPVIGRPRPNISWVKDGEPL--KQTTRVNVEETATSTVLHIKEGNKDDFGKYT 18078
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
ATN G + +L + V+ K
Sbjct: 18079 VTATNSAGTATENLSVIVLEK 18099
Score = 36.6 bits (83), Expect = 0.16
Identities = 33/131 (25%), Positives = 60/131 (45%), Gaps = 16/131 (12%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG----QNSFSLELSVVAKEVKKAPV-----ILEKLQNCGV 1183
++ L ++ ++ A N G + +FS SV+ KE + P I +L C
Sbjct: 22300 VERLVEKTEYEFRVKAKNDAGYSEPREAFS---SVIIKEPQIEPTADLTGITNQLITCKA 22356
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G P ++ + G P P WK + + T +R+S+ T L ++ + + D+G
Sbjct: 22357 --GSPFTIDVPISGRPAPKVTWKLEEMRLKET-DRVSI-TTTKDRTTLTVKDSMRGDSGR 22412
Query: 1244 YTLSAKNEAGI 1254
Y L+ +N AG+
Sbjct: 22413 YFLTLENTAGV 22423
Score = 36.6 bits (83), Expect = 0.16
Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKK-DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G + L+ V G P P W K D E C E++S+ Q T A +I+ +SD+G Y
Sbjct: 22757 GSDLVLDAAVGGKPEPKIIWTKGDKELDLC--EKVSL-QYTGKRATAVIKFCDRSDSGKY 22813
Query: 1245 TLSAKNEAG 1253
TL+ KN +G
Sbjct: 22814 TLTVKNASG 22822
Score = 36.2 bits (82), Expect = 0.21
Identities = 51/221 (23%), Positives = 85/221 (38%), Gaps = 40/221 (18%)
Query: 853 PSMPSQGLAKKN--TKSPQPVNDDNIRETKNAVI-------RDLGKKITFSDV---RPNQ 900
PS PS+ + K+ K PVN + I T N+V D G KI V +
Sbjct: 10792 PSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 10851
Query: 901 QEYKISSFEQRLMNEIEFRL--------------------ERTPVDESDDEIQHDEIPTG 940
+E++ ++ E ++++ E P + + D +
Sbjct: 10852 EEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPP 10911
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
+ I R +H +V G + + I G+P PKV W K+ R+ K R +
Sbjct: 10912 ELILDANMAREQHIKV--GDTLRLSAIIKGVPFPKVTWKKE-----DRDAPTKARIDVTP 10964
Query: 1001 TCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S L I + +D G Y++ NP G + S ++V P
Sbjct: 10965 VGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 11005
Score = 35.8 bits (81), Expect = 0.28
Identities = 20/83 (24%), Positives = 35/83 (42%), Gaps = 1/83 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V G R + G+P P W +G + D H + + L I +RD
Sbjct: 11215 LVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDT 11273
Query: 1142 GTYKCIATNKTGQNSFSLELSVV 1164
G Y+ +N G + ++ L+V+
Sbjct: 11274 GEYQITVSNAAGSKTVAVHLTVL 11296
Score = 35.8 bits (81), Expect = 0.28
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Query: 968 IVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
I+G P+PK W K GK I R + L I+ T D G YTI A NP G
Sbjct: 14098 ILGKPLPKSSWSKAGKDI--RPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 14154
Score = 35.8 bits (81), Expect = 0.28
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGH 1187
+ LT+ ++ IA N G S + + + AK+ + P I + V G
Sbjct: 17277 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 17336
Query: 1188 PVRLECRVIGMPPPVFYW-KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G P P W + D E R I ++T A L+++ A + D G Y L
Sbjct: 17337 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEI---KNTDFKALLIVKDAIRIDGGQYIL 17393
Query: 1247 SAKNEAG 1253
A N AG
Sbjct: 17394 RASNVAG 17400
Score = 35.4 bits (80), Expect = 0.36
Identities = 41/162 (25%), Positives = 70/162 (43%), Gaps = 19/162 (11%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV- 1164
W+ G+PV A KM V TG L + Y+ A N+ G + S +
Sbjct: 7329 WVACGEPV---AETKMEV--TG--------LEEGKWYAYRVKALNRQGASKPSRPTEEIQ 7375
Query: 1165 AKEVKKAPVI---LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
A + ++AP I ++ L V G + L V G P P W K + + + RI++
Sbjct: 7376 AVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDK-RITI 7434
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
++ + + I +K+SD G Y + A N G + +++
Sbjct: 7435 -ENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7475
Score = 35.4 bits (80), Expect = 0.36
Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G I G P+P + W K +++S N + D SL ++ D G
Sbjct: 16250 VHAGESFKVDADIYGKPIPTIQWIKGDQELS--NTARLEIKSTDFATSLSVKDAVRVDSG 16307
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
NY + A N G S + ++ V P
Sbjct: 16308 NYILKAKNVAGERSVTVNVKVLDRP 16332
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/94 (21%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
K ++ P + S GQ + E + G P P + W ++G ++ + +
Sbjct: 16919 KDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINV----- 16973
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ ++ TL I E +D G + T +N G
Sbjct: 16974 ---TDSLDLTTLSIKETHKDDGGQYGITVANVVG 17004
Score = 35.4 bits (80), Expect = 0.36
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 6/111 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRD 1140
+V G + +++ ++G P P ++W +G + A +++ T H+LL + +RD
Sbjct: 19494 IVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII--STDNHTLLTVKDCIRRD 19551
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKA-PVILEKL--QNCGVPEGHP 1188
G Y N G S ++ V+ K A P+ + L + C + G P
Sbjct: 19552 TGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRP 19602
Score = 35.4 bits (80), Expect = 0.36
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 4/72 (5%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +G + T I G P P W K+G+ ISKR M + L I+ D G
Sbjct: 23843 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKR----AMIATSETHTELVIKEADRGDSG 23898
Query: 1016 NYTIMAANPQGR 1027
Y ++ N G+
Sbjct: 23899 TYDLVLENKCGK 23910
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE-DTGRYSC 341
G+ ++L + +G P P + W+ K L+NS +I I + L + + G+Y
Sbjct: 24338 GSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKV 24397
Query: 342 FASNIYGTDSTSAEIYIE 359
SN++GT ++ I+
Sbjct: 24398 QLSNVFGTVDAILDVEIQ 24415
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 11/99 (11%)
Query: 437 FTKMLQNLSASEGQ-LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
FT+ LQ++ A E + FEC P KV+WY++G + + +R+ S +
Sbjct: 2130 FTQELQDVVAKEKDTMATFECETS-EPFVKVKWYKDGMEVHEGDKYRM-----HSDRKVH 2183
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ L I AED C N V + A+L V G
Sbjct: 2184 FLSILTIDTSDAEDYSCVLVEDEN----VKTTAKLIVEG 2218
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVH-SLLIDPLTQRDA 1141
+A E RL + G P P ++W P+ D ++ V + V+ +L++ + DA
Sbjct: 13688 LAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT--RVSVESSAVNTTLIVYDCQKSDA 13745
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAK 1166
G Y N G ++ + VV K
Sbjct: 13746 GKYTITLKNVAGTKEGTISIKVVGK 13770
Score = 35.0 bits (79), Expect = 0.48
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP---VILEKLQNCGVP 1184
+ ++ L ++ ++ A N G ++ V E + AP + E + V
Sbjct: 14425 ITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVR 14484
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G +R+ + G P P W KDN + + R ++ ++T + L+I + D G +
Sbjct: 14485 AGLSIRIFVPIKGRPAPEVTWTKDNINL---KNRANI-ENTESFTLLIIPECNRYDTGKF 14540
Query: 1245 TLSAKNEAG 1253
++ +N AG
Sbjct: 14541 VMTIENPAG 14549
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/129 (22%), Positives = 47/129 (36%), Gaps = 8/129 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I P++ + D V K + G+ E V G P
Sbjct: 15126 VIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPP 15185
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW ++G +E + I + LV + DSG +T TA+N G
Sbjct: 15186 PTMEWSKDGKELEGTAKLEI--------KIADFSTNLVNKDSTRRDSGAYTLTATNPGGF 15237
Query: 524 VSSIAQLHV 532
I + V
Sbjct: 15238 AKHIFNVKV 15246
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G ++D + G P P + W + G L + + + SL + + D+
Sbjct: 16248 IVVHAGESFKVDADIYGKPIPTIQW-IKGDQELSNTARLEIKSTDFATSLSVKDAVRVDS 16306
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKE-VKKAPVIL 1175
G Y A N G+ S ++ + V+ + + PV++
Sbjct: 16307 GNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI 16341
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +++ + G P PV W KD I R R + T + L ++ + D G
Sbjct: 19496 VKAGEVLKINADIAGRPLPVISWAKDGIEIE-ERARTEI-ISTDNHTLLTVKDCIRRDTG 19553
Query: 1243 WYTLSAKNEAG 1253
Y L+ KN AG
Sbjct: 19554 QYVLTLKNVAG 19564
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 18/106 (16%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIV------------------VGIPPPQVRWYCEGK 307
G+P + ++++++ E + LD + G PPP V W + K
Sbjct: 20946 GEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEK 21005
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
L + I + LTI + DTG+Y N G +S
Sbjct: 21006 NLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSS 21051
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/99 (24%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR- 1139
D++ EG + +P P ++W +G+ V AS ++ ++ + + L P + R
Sbjct: 8090 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV--KASDRLTMKNDHISAHLEVPKSVRA 8147
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVV-----AKEVKKAPV 1173
DAG Y NK G + S+ + V+ K++K + +
Sbjct: 8148 DAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDI 8186
Score = 34.7 bits (78), Expect = 0.62
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 14/144 (9%)
Query: 890 KITFSDVRPNQQEYKIS------SFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCI 943
K FS++ N E+ +S ++E R++ + P + SD D++ K
Sbjct: 15100 KANFSNILEN--EFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIK 15157
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR-REGDGTC 1002
+ K + G + G P P + W KDGK++ K+ + D +
Sbjct: 15158 VDVKFKDTVILKA--GEAFRLEADVSGRPPPTMEWSKDGKELEGT---AKLEIKIADFST 15212
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
+L + +T D G YT+ A NP G
Sbjct: 15213 NLVNKDSTRRDSGAYTLTATNPGG 15236
Score = 34.7 bits (78), Expect = 0.62
Identities = 23/82 (28%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDA 1241
V G +++ + G P P W K ++ + T + +T +A L ++ A + D+
Sbjct: 16250 VHAGESFKVDADIYGKPIPTIQWIKGDQELSNTAR---LEIKSTDFATSLSVKDAVRVDS 16306
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G Y L AKN AG S T + +
Sbjct: 16307 GNYILKAKNVAGERSVTVNVKV 16328
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 2/78 (2%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
K V G PV I G P P WF G ++ + +E + L I TT
Sbjct: 23441 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKL-RESERVTVETH-TKVAKLTIRETTI 23498
Query: 1012 DDDGNYTIMAANPQGRIS 1029
D G YT+ N G S
Sbjct: 23499 RDTGEYTLELKNVTGTTS 23516
Score = 34.3 bits (77), Expect = 0.81
Identities = 67/299 (22%), Positives = 109/299 (36%), Gaps = 33/299 (11%)
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-GTRVQLDCIVVGIP 296
AE +AS G + S + Q FTQ+L+ E T +C P
Sbjct: 2097 AEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFEC-ETSEP 2155
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
+V+WY +G E+ + +H L+I D YSC T+A++
Sbjct: 2156 FVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENV-KTTAKL 2214
Query: 357 YIEGV------SSSDSE-GDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPR 409
+EG D E + E+ I P + + V ++ + R
Sbjct: 2215 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDV--ELKSNGKYTITSRR 2272
Query: 410 VATIQQCQSPTNYLQG-----LDGK----PIIAAPVFTKMLQNLS---ASEGQLVVFECR 457
+ T QG +DGK + P +LQ LS EG +V E +
Sbjct: 2273 GRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVK 2332
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
V S + W ++G ++ S I+ K M L+I ++ ED+G ++ T
Sbjct: 2333 V-SLESVEGVWMKDGQEVQPSDRVHIVIDKQSHM--------LLIEDMTKEDAGNYSFT 2382
Score = 34.3 bits (77), Expect = 0.81
Identities = 28/137 (20%), Positives = 53/137 (38%), Gaps = 9/137 (6%)
Query: 398 VPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECR 457
VP ++ V + R P+ + + K P ++ EG+ +
Sbjct: 8046 VPDKEY-VLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVP 8104
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+ P P V W+++G ++ S R+ K A L + + D+G +T T
Sbjct: 8105 FRAVPVPTVSWHKDGKEVKASD--RLTMKNDHISAH------LEVPKSVRADAGIYTITL 8156
Query: 518 SNKYGTVSSIAQLHVRG 534
NK G+ ++ + V G
Sbjct: 8157 ENKLGSATASINVKVIG 8173
Score = 34.3 bits (77), Expect = 0.81
Identities = 19/82 (23%), Positives = 38/82 (46%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V EG ++ + +P P V W+ +GKE++ S + + L + ++ D G Y
Sbjct: 8093 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 8152
Query: 340 SCFASNIYGTDSTSAEIYIEGV 361
+ N G+ + S + + G+
Sbjct: 8153 TITLENKLGSATASINVKVIGL 8174
Score = 34.3 bits (77), Expect = 0.81
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 10/92 (10%)
Query: 268 PPRFTQKLRSR----EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI------HI 317
PP +L R +V G V + V G+P P++ W +E D +
Sbjct: 9089 PPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEV 9148
Query: 318 VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
++ L+I +A ED G Y+ ASN G+
Sbjct: 9149 SRSEAKTELSIPKAVREDKGTYTVTASNRLGS 9180
Score = 34.3 bits (77), Expect = 0.81
Identities = 36/153 (23%), Positives = 57/153 (37%), Gaps = 6/153 (3%)
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN--SFSLEL 1161
+ ++L + + + HK+ + L + D Y+ A N GQ SF +
Sbjct: 10444 INYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKP 10503
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
E+ + L+ + G L R G P P W KD + E
Sbjct: 10504 ITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV---LEDDRT 10560
Query: 1222 HQDTTGYACLLIQ-PAKKSDAGWYTLSAKNEAG 1253
H TT L + AK+SD+G Y + +N G
Sbjct: 10561 HIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 10593
Score = 34.3 bits (77), Expect = 0.81
Identities = 21/106 (19%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 428 GKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
G P+I P+ +T++++ + G V + G P+P +EWY++ D +
Sbjct: 20563 GGPVIDLPLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKD--------DKELQTN 20611
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ ++ +++I + +SGC+ N G+ S+ ++ +
Sbjct: 20612 ALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQI 20657
Score = 34.3 bits (77), Expect = 0.81
Identities = 22/65 (33%), Positives = 25/65 (38%), Gaps = 2/65 (3%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
GH V LE G P P W KD +P T L I+ AKK G YT
Sbjct: 21273 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 21330
Query: 1246 LSAKN 1250
+ N
Sbjct: 21331 VILDN 21335
Score = 34.3 bits (77), Expect = 0.81
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
AGG P P ++ E L + P + R +E V +G ++L + G P P +W
Sbjct: 23807 AGGPGEPAEVPGTVKVTEML-EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKW 23865
Query: 303 YCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
EG+++ ++ H+ L I EA D+G Y N G + ++ + G
Sbjct: 23866 TKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 23922
Query: 362 SSS 364
+S
Sbjct: 23923 PNS 23925
Score = 34.3 bits (77), Expect = 0.81
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V +G +RL + G P P+ W K+ + I + +M + + L+I+ A + D+G
Sbjct: 23843 VRQGGVIRLTIPIKGKPFPICKWTKEGQDI----SKRAMIATSETHTELVIKEADRGDSG 23898
Query: 1243 WYTLSAKNEAG 1253
Y L +N+ G
Sbjct: 23899 TYDLVLENKCG 23909
Score = 34.3 bits (77), Expect = 0.81
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 5/111 (4%)
Query: 1057 RVQERDKEPL-QERFFRPHFLQAPGDMVAHE---GRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ ER E L Q+ F H + M +H G+ R V P E+ W NG
Sbjct: 26049 KTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVE 26108
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
L ++S +GV +L I D+GTY+ + TN G+ S L V
Sbjct: 26109 -LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDV 26158
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/74 (24%), Positives = 31/74 (41%), Gaps = 1/74 (1%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F + L + V E C + V+WY G+E++ + G++H L
Sbjct: 6517 PTEFVEHLEDQTVTEFDDAVFSC-QLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLI 6575
Query: 328 IAEAFEEDTGRYSC 341
I + +D Y+C
Sbjct: 6576 IKDCRLDDECEYAC 6589
Score = 33.9 bits (76), Expect = 1.1
Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
++D G P + W +GQ L + + + V SL I ++ D GTY+ +N
Sbjct: 19108 KIDVPFKGRPQATVNWRKDGQ-TLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSN 19166
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEKL 1178
G + + + V+ + P+ ++++
Sbjct: 19167 SAGSITVPITIIVLDRPGPPGPIRIDEV 19194
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/63 (28%), Positives = 29/63 (46%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V L+ G P P + W +G L+ S + + N +L+I A +E G+Y+
Sbjct: 21273 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 21332
Query: 343 ASN 345
N
Sbjct: 21333 LDN 21335
Score = 33.5 bits (75), Expect = 1.4
Identities = 22/94 (23%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
K+++ L G V F ++G P P +W +G+ I+ + + S+
Sbjct: 11210 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV------- 11262
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L I D+G + T SN G+ + L V
Sbjct: 11263 -LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 11295
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 13/103 (12%)
Query: 428 GKPIIAA-----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
G P+IA P S G+ + E V G P P + W ++G ++
Sbjct: 17995 GVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK------ 18048
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
Q ++ E L I E +D G +T TA+N GT +
Sbjct: 18049 --QTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 18089
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 924 PVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGK 983
P D S DEI A + K V G I G P+P V W KDGK
Sbjct: 18384 PSDSSGAITARDEIDAPN--ASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGK 18441
Query: 984 QISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
++ + +++ T +L ++ D G Y + +N G
Sbjct: 18442 ELEETAARMEIKSTIQKT-TLVVKDCIRTDGGQYILKLSNVGG 18483
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 14/105 (13%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G L+ + G P P++ W +G+ + A+ + +L++ + D
Sbjct: 18412 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18471
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
G Y +N G K P+ ++ L G PEG
Sbjct: 18472 GQYILKLSNVGG--------------TKSIPITVKVLDRPGPPEG 18502
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G LE + G P P W KD + + T R+ + + T L+++ ++D G
Sbjct: 18414 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGG 18472
Query: 1243 WYTLSAKNEAGIVS 1256
Y L N G S
Sbjct: 18473 QYILKLSNVGGTKS 18486
Score = 33.5 bits (75), Expect = 1.4
Identities = 36/169 (21%), Positives = 67/169 (39%), Gaps = 17/169 (10%)
Query: 873 DDNIRETKNAVIRDLGKKITFSDVRPNQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDE 931
D R NA IR+ + T D++ Q+ +++++ + M+E + +
Sbjct: 23081 DQWYRVHTNATIRNT--EFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEI------EP 23132
Query: 932 IQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEH 991
++ EIP + D K + G+ + + G P P + W K G ++ R
Sbjct: 23133 VERIEIPD----LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR--- 23185
Query: 992 CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ + L ++ D G YTI A N G+ S + + V P
Sbjct: 23186 -AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 23233
Score = 33.1 bits (74), Expect = 1.8
Identities = 27/107 (25%), Positives = 38/107 (35%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
DK L P + +G +V G P PE W NG +
Sbjct: 2021 DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYW 2080
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV 1168
E V L+I +T D+ + A N G+ S L V AK++
Sbjct: 2081 YWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQL 2127
Score = 33.1 bits (74), Expect = 1.8
Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 4/113 (3%)
Query: 917 EFRLERTPVDESDDEIQHDEIPTGKCIA-PIFDKRLKH-FRVTEGSPVTFTCKIVGIPVP 974
EFR++ D ++ +E+ + + P+ D +L V G + + G P P
Sbjct: 11867 EFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFP 11926
Query: 975 KVYWFKDGKQIS-KRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
+V W KD R+ K+ D + + D G Y + A N G
Sbjct: 11927 EVAWTKDKDATDLTRSPRVKIDTRADSS-KFSLTKAKRSDGGKYVVTATNTAG 11978
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 440 MLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT 499
M + ++ G+ + E V G P P +W + + S + + S+
Sbjct: 12599 MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI-------- 12650
Query: 500 LVIAEVFAEDSGCFTCTASNKYGT 523
L+I +V +DSG ++ TA N GT
Sbjct: 12651 LIIKDVTRKDSGYYSLTAENSSGT 12674
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/87 (26%), Positives = 32/87 (36%), Gaps = 8/87 (9%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDG---KQISKRNEHCKMRREGD 999
I P F F V G + +G P P V W KD KQ ++ N +
Sbjct: 15841 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN-----AESTE 15895
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQG 1026
L I+ +D G+Y + N G
Sbjct: 15896 NNSLLTIKDACREDVGHYVVKLTNSAG 15922
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/75 (28%), Positives = 33/75 (44%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V+W + I D+ + +LV+ V DSG +T T
Sbjct: 16661 IKGRPTPEVKWGKVDGEIRDAAIIDV----------TSSFTSLVLDNVNRYDSGKYTLTL 16710
Query: 518 SNKYGTVSSIAQLHV 532
N GT S+ + V
Sbjct: 16711 ENSSGTKSAFVTVRV 16725
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/99 (23%), Positives = 39/99 (39%), Gaps = 5/99 (5%)
Query: 945 PIFDKRLKHFRVTE---GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
P+ D L++ V + G+ V I G P P + W+KD K++ C
Sbjct: 20565 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV--ENTTDL 20622
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S+ I+ + G Y + N G S + + + P
Sbjct: 20623 ASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 20661
Score = 33.1 bits (74), Expect = 1.8
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 15/184 (8%)
Query: 1147 IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWK 1206
+ T KT + + + LS + AP I ++++ VP G R V P W
Sbjct: 26045 LKTQKTSERKYEV-LSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWY 26103
Query: 1207 KDNETIPCTRERISMHQ-DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI-- 1263
+ + +E +H +T+G L I D+G Y N G S A LD+
Sbjct: 26104 HNGVEL---QESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTG 26160
Query: 1264 -----YAQWHHQIPPPMSVRPSGSR---YGSLTSKGLDIFSAFSSMESTMVYSCSSRSVV 1315
YA P SV P +R Y + K A SS+ +R +
Sbjct: 26161 GDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESL 26220
Query: 1316 ESDE 1319
S E
Sbjct: 26221 SSYE 26224
Score = 32.7 bits (73), Expect = 2.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ R+ +V G P P++TW G+ VL L+++ L I + D G Y
Sbjct: 11618 GQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 11676
Query: 1147 IATNKTGQNSFSLELSVV 1164
A N +G S ++V+
Sbjct: 11677 SAKNSSGHAQGSAIVNVL 11694
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVI-----LEKLQNCGVPEG 1186
+ L + ++ A N+ G L+ ++ KE+ + P I + KL V G
Sbjct: 12259 VTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVI--VRAG 12316
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
P+RL V G P P W+K + ++ + DT + L+I + + D+G Y+L
Sbjct: 12317 CPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDL-VDTMAF--LVIPNSTRDDSGKYSL 12373
Query: 1247 SAKNEAG 1253
+ N AG
Sbjct: 12374 TLVNPAG 12380
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 9/81 (11%)
Query: 444 LSASEGQLVVFEC-RVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L+ G +V + G P PK W + G I S +I SM L I
Sbjct: 14083 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSM--------LTI 14134
Query: 503 AEVFAEDSGCFTCTASNKYGT 523
+D+G +T TA+N +GT
Sbjct: 14135 KYATRKDAGEYTITATNPFGT 14155
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 14/127 (11%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++++ V+G P P V W + L+ + ++ L I E D+G Y
Sbjct: 14775 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 14834
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP----AV 398
A NI G I + D G P K +EVSS T + PP V
Sbjct: 14835 ARNIVGEVGDVITIQVH-----DIPGPPTGP-----IKFDEVSSDFVTFSWDPPENDGGV 14884
Query: 399 PQAQHLV 405
P + ++V
Sbjct: 14885 PISNYVV 14891
Score = 32.7 bits (73), Expect = 2.4
Identities = 26/122 (21%), Positives = 46/122 (37%), Gaps = 8/122 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I + T + D + + K + + G+ E V G P
Sbjct: 17290 VIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPL 17349
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW R IE+S I +++ L++ + D G + ASN G+
Sbjct: 17350 PTIEWLRGDKEIEESARCEIKNTDFKAL--------LIVKDAIRIDGGQYILRASNVAGS 17401
Query: 524 VS 525
S
Sbjct: 17402 KS 17403
Score = 32.7 bits (73), Expect = 2.4
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 10/131 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVI---LEKLQNCGVPEGHP 1188
I LT ++ + NK G + S +AKE ++ P+ E + V G
Sbjct: 19839 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 19898
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTT-GYACLLIQPAKKSDAGWYTLS 1247
+ G P P W K P T R + DTT L I+ A ++D+G YTL+
Sbjct: 19899 FTMTVPFRGRPVPNVLWSK-----PDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLT 19953
Query: 1248 AKNEAGIVSCT 1258
+N S T
Sbjct: 19954 IQNVLSAASLT 19964
Score = 32.7 bits (73), Expect = 2.4
Identities = 28/151 (18%), Positives = 56/151 (37%), Gaps = 8/151 (5%)
Query: 383 EVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
+VS T + P ++A+ V TI + + D +
Sbjct: 21602 DVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFD 21661
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L G+ + + V+G P P+V W+++G IE + I + +L +
Sbjct: 21662 GLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST--------SLFV 21713
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ + G +T A N G+ + ++ V+
Sbjct: 21714 RDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 21744
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/94 (25%), Positives = 38/94 (40%), Gaps = 10/94 (10%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ + +G ++ +KG P P +W +EG I K +A E LV
Sbjct: 23839 EGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI----------SKRAMIATSETHTELV 23888
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGN 535
I E DSG + NK G + ++ V G+
Sbjct: 23889 IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 23922
Score = 32.3 bits (72), Expect = 3.1
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 5/81 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G RL + G+P P++TW + DA K + T V S L I D G Y
Sbjct: 10928 GDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAHEDGGIYS 10983
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
N G + S+++ V+ K
Sbjct: 10984 LTVENPAGSKTVSVKVLVLDK 11004
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCE--GKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V G ++L+ V G P P+V W + +L SP + I + ++ +A D G
Sbjct: 11908 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 11967
Query: 338 RYSCFASNIYGT 349
+Y A+N G+
Sbjct: 11968 KYVVTATNTAGS 11979
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 7/77 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+ V E ++G P P V W ++G +E++ + + TLV+ +
Sbjct: 18417 GETFVLEADIRGKPIPDVVWSKDGKELEET-------AARMEIKSTIQKTTLVVKDCIRT 18469
Query: 509 DSGCFTCTASNKYGTVS 525
D G + SN GT S
Sbjct: 18470 DGGQYILKLSNVGGTKS 18486
Score = 32.3 bits (72), Expect = 3.1
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 9/120 (7%)
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA-HEGRLCRLDCKVSGLPPPELT 1105
S G G ++ P E R H GD+V G LD V G P P++
Sbjct: 22721 SKGSESTGPVTCRDEYAPPKAELDARLH-----GDLVTIRAGSDLVLDAAVGGKPEPKII 22775
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR-DAGTYKCIATNKTGQNSFSLELSVV 1164
W + + D K+ ++ TG + + R D+G Y N +G + S+ + V+
Sbjct: 22776 WTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVL 22833
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
++ L + V E +C V P + W +GK L + +I G+ L IA
Sbjct: 2577 SKPLTDQTVAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAAT 2635
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
+D G Y+ + T TSA++ +E V
Sbjct: 2636 KLDDIGEYTYKVA----TSKTSAKLKVEAV 2661
Score = 32.0 bits (71), Expect = 4.0
Identities = 27/131 (20%), Positives = 52/131 (39%), Gaps = 10/131 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCI 291
EA+RR+ + GG+ P +P + + P +F ++++ + E V I
Sbjct: 4780 EAERRKLRPGS----GGEKPPDEAPFTYQLK---AVPLKFVKEIKDIILTESEFVGSSAI 4832
Query: 292 VVGIPPPQVR---WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ P W +G + SP + G L I + D G Y+C
Sbjct: 4833 FECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNK 4892
Query: 349 TDSTSAEIYIE 359
+++A++ +E
Sbjct: 4893 EKTSTAKLVVE 4903
Score = 32.0 bits (71), Expect = 4.0
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
RL + G P PE+ W + +L D + + + L+ID +T+ D+G Y N
Sbjct: 18821 RLFVTIKGRPEPEVKWE-KAEGILTDRAQIEVT--SSFTMLVIDNVTRFDSGRYNLTLEN 18877
Query: 1151 KTGQ----------NSFSLELSVVAKEVKKAPVIL 1175
+G +S S +++ +EVKK V L
Sbjct: 18878 NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTL 18912
Score = 32.0 bits (71), Expect = 4.0
Identities = 42/197 (21%), Positives = 71/197 (36%), Gaps = 33/197 (16%)
Query: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
KIVG + K +Q ++R C + C + + D + I+A N G
Sbjct: 21580 KIVGYSIEK-------RQGNERWVRCNFTDVSE--CQYTVTGLSPGDRYEFRIIARNAVG 21630
Query: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
IS P +S G ++ + P+ E F P + ++
Sbjct: 21631 TISP---------PSQSS---------GIIMTRDENVPPIVE--FGPEYFDG---LIIKS 21667
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G R+ V G P P +TW +G + + + G SL + T+ G Y
Sbjct: 21668 GESLRIKALVQGRPVPRVTWFKDGVEI-EKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 21726
Query: 1147 IATNKTGQNSFSLELSV 1163
A N +G +++ V
Sbjct: 21727 EAKNASGSAKAEIKVKV 21743
Score = 32.0 bits (71), Expect = 4.0
Identities = 18/75 (24%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
+D +SG P P++TW L + L + + +L + + D+G Y N
Sbjct: 22362 IDVPISGRPAPKVTWKLE-EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22420
Query: 1152 TGQNSFSLELSVVAK 1166
G +FS+ + V+ +
Sbjct: 22421 AGVKTFSVTVVVIGR 22435
Score = 31.6 bits (70), Expect = 5.3
Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 8/90 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE-EICTLVI 502
L+ G + E V+G P P+V W ++ +D+ D L + PR + + +
Sbjct: 11906 LTVKAGDTIRLEAGVRGKPFPEVAWTKD----KDATD---LTRSPRVKIDTRADSSKFSL 11958
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ D G + TA+N G+ + A ++V
Sbjct: 11959 TKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V W ++ I K ++ E L+I E D+G F T
Sbjct: 14495 IKGRPAPEVTWTKDN----------INLKNRANIENTESFTLLIIPECNRYDTGKFVMTI 14544
Query: 518 SNKYGTVSSIAQLHV 532
N G S + V
Sbjct: 14545 ENPAGKKSGFVNVRV 14559
Score = 31.6 bits (70), Expect = 5.3
Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 10/101 (9%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P P+V+W + ++ D + LVI V DSG + T
Sbjct: 18826 IKGRPEPEVKWEKAEGILTDRAQIEV----------TSSFTMLVIDNVTRFDSGRYNLTL 18875
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEP 558
N G+ ++ + V + N ++ + + EP
Sbjct: 18876 ENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 18916
Score = 31.6 bits (70), Expect = 5.3
Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 13/97 (13%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
KP + P T N+ A E QL + + KG P V W ++G ++++ + K
Sbjct: 19089 KPSVELPFHTF---NVKARE-QLKI-DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSK- 19142
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ +L I E ED G + SN G+++
Sbjct: 19143 -------TVTSLSIKEASKEDVGTYELCVSNSAGSIT 19172
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 8/81 (9%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
Q ++ G + + G P+PKV W E ++++ I K R+ TL
Sbjct: 22350 QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRT--------TLT 22401
Query: 502 IAEVFAEDSGCFTCTASNKYG 522
+ + DSG + T N G
Sbjct: 22402 VKDSMRGDSGRYFLTLENTAG 22422
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP T I G P PKV W + ++ K + + D T +L ++ + D G Y
Sbjct: 22357 GSPFTIDVPISGRPAPKVTWKLEEMRL-KETDRVSITTTKDRT-TLTVKDSMRGDSGRYF 22414
Query: 1019 IMAANPQG 1026
+ N G
Sbjct: 22415 LTLENTAG 22422
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++L V G PPP + W +G +L + I ++ +L L + + D G+Y+
Sbjct: 23156 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--LIVDKVNRYDAGKYTIE 23213
Query: 343 ASNIYGTDSTSAEIYI 358
A N G S + + +
Sbjct: 23214 AENQSGKKSATVLVKV 23229
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/90 (24%), Positives = 39/90 (43%), Gaps = 7/90 (7%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQP--VLPDASHKM---LVRETGVHS--LLID 1134
+V G R+ + G P P+ +W +G+ + D H + ET +S ++I
Sbjct: 9515 LVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIP 9574
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
+ G Y A NK GQ + + + V+
Sbjct: 9575 ECKRSHTGKYSITAKNKAGQKTANCRVKVM 9604
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G + ++ G P P + W K+GK + R + + ++ L I+ D G
Sbjct: 11615 VRVGQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLP-RVELQIKEAVRADHG 11672
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y I A N G S + V P
Sbjct: 11673 KYIISAKNSSGHAQGSAIVNVLDRP 11697
Score = 31.2 bits (69), Expect = 6.9
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 1162 SVVAKEVKKAP-VILEKLQNCG--VPEGHPVRLEC-RVIGMPPPVFYWKKDNETIPCTRE 1217
+++ K+ +AP ++L+ G + G + L ++G P P W K + I
Sbjct: 14061 TIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI--RPS 14118
Query: 1218 RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
I+ T + L I+ A + DAG YT++A N G
Sbjct: 14119 DITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 14154
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 6/90 (6%)
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+RL + G P P W+K E I R +I + T+ + L+I + D+G Y L+
Sbjct: 18820 LRLFVTIKGRPEPEVKWEKA-EGILTDRAQIEV---TSSFTMLVIDNVTRFDSGRYNLTL 18875
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
+N +G S TA +++ P +++R
Sbjct: 18876 ENNSG--SKTAFVNVRVLDSPSAPVNLTIR 18903
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/84 (26%), Positives = 33/84 (39%), Gaps = 6/84 (7%)
Query: 1076 LQAPGDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS---- 1130
L GD + G + V+GLP P++ W N + + +E S
Sbjct: 9096 LSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT 9155
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTG 1153
L I + D GTY A+N+ G
Sbjct: 9156 ELSIPKAVREDKGTYTVTASNRLG 9179
Score = 30.8 bits (68), Expect = 9.0
Identities = 20/69 (28%), Positives = 27/69 (39%), Gaps = 4/69 (5%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDDDGNY 1017
G T + G P PKV WFKD + + + H K T +L D G Y
Sbjct: 10528 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTT---PATLALEKIKAKRSDSGKY 10584
Query: 1018 TIMAANPQG 1026
++ N G
Sbjct: 10585 CVVVENSTG 10593
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/79 (21%), Positives = 32/79 (40%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
E + +L + G P P V W L + + + +L + + + D G+Y+
Sbjct: 13691 ENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTI 13750
Query: 342 FASNIYGTDSTSAEIYIEG 360
N+ GT + I + G
Sbjct: 13751 TLKNVAGTKEGTISIKVVG 13769
Score = 30.8 bits (68), Expect = 9.0
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYKCIATNKTGQ 1154
+ G P P+ +W G+ + P S + T S+L I T++DAG Y ATN G
Sbjct: 14098 ILGKPLPKSSWSKAGKDIRP--SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGT 14155
Query: 1155 NSFSLELSVVAKEVKKAPV 1173
++++V+ PV
Sbjct: 14156 KVEHVKVTVLDVPGPPGPV 14174
Score = 30.8 bits (68), Expect = 9.0
Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 12/76 (15%)
Query: 458 VKGAPSPKVEWYRE-GTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
+KG P+P+V+W R+ G ++ + S+ L++ V DSG + T
Sbjct: 15579 IKGRPAPEVKWARDHGESLDKA-----------SIESTSSYTLLIVGNVNRFDSGKYILT 15627
Query: 517 ASNKYGTVSSIAQLHV 532
N G+ S+ + V
Sbjct: 15628 VENSSGSKSAFVNVRV 15643
Score = 30.8 bits (68), Expect = 9.0
Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 8/88 (9%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE---GDGTCSLHIESTTSD 1012
V G + I G P+P + W KDG +I +R R E D L ++
Sbjct: 19496 VKAGEVLKINADIAGRPLPVISWAKDGIEIEER-----ARTEIISTDNHTLLTVKDCIRR 19550
Query: 1013 DDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y + N G S + + V P
Sbjct: 19551 DTGQYVLTLKNVAGTRSVAVNCKVLDKP 19578
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/77 (22%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+++ + G P P + W ++G IE+ I+ ++ L + +
Sbjct: 19499 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTL--------LTVKDCIRR 19550
Query: 509 DSGCFTCTASNKYGTVS 525
D+G + T N GT S
Sbjct: 19551 DTGQYVLTLKNVAGTRS 19567
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAGNLHSLTIAEAFEEDTGR 338
V G+ +++D + G P P+V +G L+ + + + A NL ++ + E+ D GR
Sbjct: 20183 VRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL-TINLKESVTADAGR 20241
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y A+N GT I +
Sbjct: 20242 YEITAANSSGTTKAFINIVV 20261
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 970 GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRIS 1029
G P P + W KDG + K +E + + + +L I++ + G YT++ N RI+
Sbjct: 21284 GKPKPSISWLKDGLPL-KESEFVRFSKT-ENKITLSIKNAKKEHGGKYTVILDNAVCRIA 21341
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 223 bits (568), Expect = 9e-58
Identities = 144/450 (32%), Positives = 227/450 (50%), Gaps = 47/450 (10%)
Query: 878 ETKNAVIRD-LGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD- 935
E + A+IR + K QE+ ISSFE+RL+ EIE+R+ +T ++E +E +
Sbjct: 1173 EKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEK 1232
Query: 936 ---EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
+I + + FD R+K++R+ EG VTF CK+ G P+PK+ W+KDGK+I K E
Sbjct: 1233 MAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRI-KHGERY 1291
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL------------- 1039
+M DG SL I +D+G YT A+N +G CSG L V+
Sbjct: 1292 QMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLE 1351
Query: 1040 ----------------PIR--------SRLTSAGQSHRGRS---RVQERDKEPLQERFFR 1072
PIR +R++ A S S R++E D+ L ER ++
Sbjct: 1352 PVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL-ERLYK 1410
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F+ P EG+ R D KV G P PE W +GQ ++ D +HK++++E G SL+
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I P T D+G + +A N+ G++S S+ L+V A E + P+ +EKL+N + EG + ++
Sbjct: 1471 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1530
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
R G P P W K+++ I + + T G A L I D+ WYT +A N+A
Sbjct: 1531 VRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKA 1590
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS 1282
G + ++++ ++ P + P G+
Sbjct: 1591 GRDTTRCKVNVEVEFAEPEPERKLIIPRGT 1620
Score = 111 bits (277), Expect = 5e-24
Identities = 91/322 (28%), Positives = 141/322 (43%), Gaps = 17/322 (5%)
Query: 950 RLKHFRVTEGSPVTFTCKIVGIPVP-KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
++ H EG V + CKI +V W+ +Q+ + +E ++ E DG L+++
Sbjct: 25201 QIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQL-ENSEKYEITYE-DGVAILYVKD 25258
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER-DKEPLQ 1067
T DDG Y N G S L V+ + R R +++ R D L
Sbjct: 25259 ITKLDDGTYRCKVVNDYGEDSSYAELFVKGV----REVYDYYCRRTMKKIKRRTDTMRLL 25314
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET- 1126
ER P F + A+ G R ++ P P +TW +GQ + P + K E+
Sbjct: 25315 ER--PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 25372
Query: 1127 -GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNC 1181
G++ L I+ +T D Y +A NK G++S +L+V + P+ L N
Sbjct: 25373 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 25432
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
EG V E RV G+PPP W+KD + + +H+ YA L I+ D
Sbjct: 25433 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYA-LHIRDTLPEDT 25491
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G+Y ++A N AG SC A L +
Sbjct: 25492 GYYRVTATNTAGSTSCQAHLQV 25513
Score = 105 bits (262), Expect = 3e-22
Identities = 78/264 (29%), Positives = 111/264 (42%), Gaps = 35/264 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L++ V EG V L+C + G P P V WY E ++E+S D I + L
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 955
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I EAF ED+GR++C A N GT STS + ++ + E
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE-------------------- 995
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKP-IIAAPVFTKMLQNLSA 446
T+AV + + V V + G P I PV K++
Sbjct: 996 --TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV----- 1048
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG VVF C+V G P P V W + G + +++ K C LVI+ F
Sbjct: 1049 -EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGE------CKLVISMTF 1101
Query: 507 AEDSGCFTCTASNKYGTVSSIAQL 530
A+D+G +T NK+G S+ A L
Sbjct: 1102 ADDAGEYTIVVRNKHGETSASASL 1125
Score = 105 bits (262), Expect = 3e-22
Identities = 105/403 (26%), Positives = 155/403 (38%), Gaps = 81/403 (20%)
Query: 173 IRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQE 232
+R R+ K +E Q V++ + D+ + + I R V +E++
Sbjct: 3101 VRIRSIKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYV---VERRI 3156
Query: 233 AKRREAEQAASEAAGGDTTPGSSPSS--LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+ +E S+A G + SS LY P +PP+ Q+L+ V G +
Sbjct: 3157 HRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAP--EPPQVLQELQPVTVQSGKPARFCA 3214
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
++ G P P++ WY E + L + G ++L + EAF ED Y+C A N YG
Sbjct: 3215 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVA 3274
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRV 410
+TSA + +E EV SP V PPA+
Sbjct: 3275 TTSASLSVE---------------------VPEVVSPDQEMPVYPPAI------------ 3301
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYR 470
LQ+ SEGQ F+CRV G KV WY
Sbjct: 3302 ---------------------------ITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYS 3333
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+ I+ S FR M + E+ L IAE + ED G +T ASN G VSS A L
Sbjct: 3334 KDKKIKPSRFFR--------MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3385
Query: 531 HVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQP 573
+ G N ++NS +++ P + PS QP
Sbjct: 3386 SLEGFSKFEEN----TSNSQWHVSLSVSFKKEPLGQKPSFIQP 3424
Score = 104 bits (260), Expect = 5e-22
Identities = 86/321 (26%), Positives = 143/321 (44%), Gaps = 35/321 (10%)
Query: 255 SPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD 314
S S + +EPLGQ P F Q L S V G V+ V GIP P+++W+ + + + D
Sbjct: 3405 SLSVSFKKEPLGQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKD 3464
Query: 315 I--HIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK 372
+ H ++ + + I +A+ E G+YSC A+N G + +A + + + P
Sbjct: 3465 VVFHFEESTGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTV-------TPKAPES 3517
Query: 373 EEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQ-----CQSPTNYLQGLD 427
RI++ E+ +S+ + A + H A+ +++ I + +SP Y D
Sbjct: 3518 ILHERIEQEIEMEMKEFSSSFL-SAEEEGLH-SAELQLSKINETLELLSESPV-YPTKFD 3574
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
+ P+F K + N S G + V G P PK++W+ G L+ S D++ +
Sbjct: 3575 SEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFV--- 3631
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV----RGNEDLSNNGS 543
+ +L+I ED G +TC ASN YG A L + G++D +
Sbjct: 3632 -----FDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESA 3686
Query: 544 LHSANSTTNLAAIEPQPSPPH 564
+ A S L P PPH
Sbjct: 3687 V--AKSLEKLGG----PCPPH 3701
Score = 103 bits (257), Expect = 1e-21
Identities = 94/372 (25%), Positives = 147/372 (39%), Gaps = 57/372 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F + L RV G V F ++ GIP P++ WF + + I + E G +
Sbjct: 3419 PSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALM 3478
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMV-------------------QSLPIRSRL 1045
I S+ G Y+ AAN G +C+ L V + S
Sbjct: 3479 LIVDAYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEIEMEMKEFSSSF 3538
Query: 1046 TSAGQS--HRGR---SRVQER----DKEPLQERFFR-------PHFLQAPGDMVAHEGRL 1089
SA + H S++ E + P+ F P F++ + G +
Sbjct: 3539 LSAEEEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDV 3598
Query: 1090 CRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIAT 1149
L V G+P P++ W NG + P A +K V + HSL+I D G Y C+A+
Sbjct: 3599 ATLSVTVIGIPKPKIQWFFNGVLLTPSADYKF-VFDGDDHSLIILFTKLEDEGEYTCMAS 3657
Query: 1150 NKTGQNSFSLEL---------------SVVAKEVKKA-----PVILEKLQNCGVPEGHPV 1189
N G+ S L S VAK ++K P L++L+ +G P
Sbjct: 3658 NDYGKTICSAYLKINSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPA 3717
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
E V+G P P W K+N+ + CT ++ + G ++ ++ D+G Y A+
Sbjct: 3718 IFEYTVVGEPAPTVTWFKENKQL-CTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAE 3776
Query: 1250 NEAGIVSCTARL 1261
N G +C A L
Sbjct: 3777 NMLGESTCAAEL 3788
Score = 102 bits (253), Expect = 3e-21
Identities = 92/339 (27%), Positives = 138/339 (40%), Gaps = 49/339 (14%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
+ L+ V G P F I G P PK+ W+K+ +Q+ CK +G L IE+
Sbjct: 3197 QELQPVTVQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEA 3255
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
+D YT A N G + S L V+ + S P QE
Sbjct: 3256 FP-EDAAVYTCEAKNDYGVATTSASLSVEVPEVVS---------------------PDQE 3293
Query: 1069 RFFRPHFLQAP-GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P + P D V EG+ R C+VSG +++W + + P +M E
Sbjct: 3294 MPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFED- 3351
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV------------------VAKEVK 1169
+ L I D GTY +A+N GQ S + LS+ ++ K
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFK 3411
Query: 1170 KAPV-----ILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
K P+ ++ L + V G VR RV G+P P W + + I T++ + ++
Sbjct: 3412 KEPLGQKPSFIQPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEE 3471
Query: 1225 TTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+TG A +LI A AG Y+ A N AG +C A L +
Sbjct: 3472 STGMALMLIVDAYSEHAGQYSCKAANSAGEATCAATLTV 3510
Score = 98.2 bits (243), Expect = 5e-20
Identities = 94/372 (25%), Positives = 142/372 (38%), Gaps = 76/372 (20%)
Query: 957 TEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGN 1016
+EG P F C++ G + KV W+ K+I K + +M + D T L I +D+G
Sbjct: 3311 SEGQPARFQCRVSGTDL-KVSWYSKDKKI-KPSRFFRMTQFED-TYQLEIAEAYPEDEGT 3367
Query: 1017 YTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFL 1076
YT +A+N G++S + +L ++ TS Q H S KEPL ++ P F+
Sbjct: 3368 YTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLS--VSFKKEPLGQK---PSFI 3422
Query: 1077 QAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE-TGVHSLLIDP 1135
Q + H G R +VSG+P PE+ W N Q +LP E TG+ +LI
Sbjct: 3423 QPLSSLRVHNGETVRFHARVSGIPKPEIQWFHNQQLILPTKDVVFHFEESTGMALMLIVD 3482
Query: 1136 LTQRDAGTYKCIATNKT------------------------------------------- 1152
AG Y C A N
Sbjct: 3483 AYSEHAGQYSCKAANSAGEATCAATLTVTPKAPESILHERIEQEIEMEMKEFSSSFLSAE 3542
Query: 1153 --GQNSFSLELSVVAKEVK------------------KAPVILEKLQNCGVPEGHPVRLE 1192
G +S L+LS + + ++ P+ ++++ N + G L
Sbjct: 3543 EEGLHSAELQLSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDVATLS 3602
Query: 1193 CRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
VIG+P P W + + P + D L+I K D G YT A N+
Sbjct: 3603 VTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHS---LIILFTKLEDEGEYTCMASND 3659
Query: 1252 AGIVSCTARLDI 1263
G C+A L I
Sbjct: 3660 YGKTICSAYLKI 3671
Score = 98.2 bits (243), Expect = 5e-20
Identities = 131/585 (22%), Positives = 217/585 (37%), Gaps = 90/585 (15%)
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
+ E H+ E Q +K E + SE+ T + E G P F +++ + ++
Sbjct: 3542 EEEGLHSAELQLSKINETLELLSESPVYPTK--------FDSEKEGTGPIFIKEVSNADI 3593
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
G L V+GIP P+++W+ G L S D V G+ HSL I ED G Y+
Sbjct: 3594 SMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYT 3653
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C ASN YG SA + I +S EG + E + + K E P
Sbjct: 3654 CMASNDYGKTICSAYLKI----NSKGEGHKDTETESAVAKSLEKLGGP------------ 3697
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
P F K L+ + ++G +FE V G
Sbjct: 3698 --------------------------------CPPHFLKELKPIRCAQGLPAIFEYTVVG 3725
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P+P V W++E + S + I+ P T ++ + EDSG + C A N
Sbjct: 3726 EPAPTVTWFKENKQLCTSVYYTIIH-------NPNGSGTFIVNDPQREDSGLYICKAENM 3778
Query: 521 YGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEG 580
G + A+L V ED + A ST A E P P + P+VE +
Sbjct: 3779 LGESTCAAELLVL-LEDTDMTDTPCKAKSTPE--APEDFPQTP-LKGPAVEALDSEQEIA 3834
Query: 581 VLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSE--------AGVVTTRQTRPDSFQE-- 630
V +++ + K +E SS+ ++ + P+S +E
Sbjct: 3835 TFVKDTILKAALITEENQQLSYEHIAKANELSSQLPLGAQELQSILEQDKLTPESTREFL 3894
Query: 631 RFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPF 690
NG P+KEP P L + S + ++ E+ + Q + K FP
Sbjct: 3895 CINGSI-----HFQPLKEPSPNLQLQIVQSQKTFSKEGILMPEEPETQAVLSDTEKIFPS 3949
Query: 691 SMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSST 750
+M++ N+ + + + S P T+ ++P V +
Sbjct: 3950 AMSIEQINSLTVEPLKTLLAEPEGNYPQSSIEPPMHSYLTSVAEEVLSPKEKTVSDTNRE 4009
Query: 751 PQ-TIQRTVSKESLLVSH-------PSVQTKSPGGLSIQNEPLPP 787
+ T+Q+ ++ +L++S S+Q+ + EPL P
Sbjct: 4010 QRVTLQKQEAQSALILSQSLAEGHVESLQSPDVMISQVNYEPLVP 4054
Score = 94.0 bits (232), Expect = 9e-19
Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 37/255 (14%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + L+ V EGS TF I G PVP+V WF+DG+ IS DG
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + T + G Y++ A N G+ + + L+V++ +
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-----------------------ET 101
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
P P+F+Q M +G RL +V+G+P P + + +G + + +
Sbjct: 102 AP-------PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQ-IS 153
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE---VKKAPVILEKLQN 1180
+E ++SLLI D+GTY ATN G+ + + EL V +E KK I+ Q
Sbjct: 154 QEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ- 212
Query: 1181 CGVPEGHPVRLECRV 1195
+ E R+E ++
Sbjct: 213 --ISESRQTRIEKKI 225
Score = 91.7 bits (226), Expect = 4e-18
Identities = 58/165 (35%), Positives = 88/165 (53%), Gaps = 12/165 (7%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F Q+L+S V +G++V+L V GIP P V++Y +G E+++S D I Q G+L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL 162
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG--------VSSSDSEGDPNKEEMNRIQ 379
IAEA+ ED+G YS A+N G +++AE+ ++G + S ++ RI+
Sbjct: 163 IAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIE 222
Query: 380 KPNE----VSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
K E S T VI A Q PR+ + +SPT
Sbjct: 223 KKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSPT 267
Score = 90.5 bits (223), Expect = 1e-17
Identities = 105/416 (25%), Positives = 150/416 (36%), Gaps = 90/416 (21%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F K +K +V E F C+ V P V W KD +++ + + K+++E L I
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECE-VSEPDITVQWMKDDQEL-QITDRIKIQKE-KYVHRLLI 3070
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR--------- 1057
ST D G YT++A G +S + L V+ +R R + R
Sbjct: 3071 PSTRMSDAGKYTVVAG---GNVS-TAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNE 3126
Query: 1058 -----------------VQERDKEPLQERFFR---------------------------- 1072
VQER K ++ R R
Sbjct: 3127 DDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLY 3186
Query: 1073 ------PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P LQ + G+ R +SG P P+++W Q + K L +
Sbjct: 3187 VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL-HDG 3245
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK--------APVILEKL 1178
++LL+ DA Y C A N G + S LSV EV P I+ L
Sbjct: 3246 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3305
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ EG P R +CRV G V ++ KD + P R++ +DT L I A
Sbjct: 3306 QDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ---LEIAEAYP 3362
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDI-----------YAQWHHQIPPPMSVRPSGSR 1283
D G YT A N G VS TA L + +QWH + P G +
Sbjct: 3363 EDEGTYTFVASNAVGQVSSTANLSLEGFSKFEENTSNSQWHVSLSVSFKKEPLGQK 3418
Score = 90.5 bits (223), Expect = 1e-17
Identities = 91/376 (24%), Positives = 143/376 (38%), Gaps = 70/376 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V EG F+C G PVP V W + G+ +S H + T I S + D+G
Sbjct: 26200 VYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKST--FEISSVQASDEG 26257
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG---QSHRGRSRVQERDKEPLQERFFR 1072
NY+++ N +G+ L +Q + + ++ +S R + E K P + +
Sbjct: 26258 NYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPE 26317
Query: 1073 PHFLQA---------PGDMVAH-----------------EGRLCRLDCKV--SGLPPPEL 1104
P +A P + V H + +L C V S L E+
Sbjct: 26318 PSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEV 26377
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL----- 1159
TW +G+ + + + G + L I+ LT+ D G Y C + + G + +L
Sbjct: 26378 TWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQ 26437
Query: 1160 -----------------------ELSVVAKEVKKA-------PVILEKLQNCGVPEGHPV 1189
E +V K KA PVI+ LQ+ V
Sbjct: 26438 AFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVA 26497
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+ + G P P W KD + I + + +D G+ L I SD+G YT + K
Sbjct: 26498 KFAVKATGEPRPTAIWTKDGKAI-TQGGKYKLSEDKGGF-FLEIHKTDTSDSGLYTCTVK 26555
Query: 1250 NEAGIVSCTARLDIYA 1265
N AG VS + +L I A
Sbjct: 26556 NSAGSVSSSCKLTIKA 26571
Score = 89.4 bits (220), Expect = 2e-17
Identities = 70/308 (22%), Positives = 131/308 (42%), Gaps = 43/308 (13%)
Query: 259 LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV 318
L + L P F + RS+ + EG V C + G P P++ W+ + S ++ I
Sbjct: 26752 LTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSIS 26811
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI---------------EGVSS 363
++ N++SL I A D+G+Y+ A N G S +A + + G +S
Sbjct: 26812 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTS 26871
Query: 364 SDSEGDPNKEEMNRIQKPNEVSSPPTTSA----VIPPAVPQAQHLVAQPR---------- 409
+M+ ++ SS ++SA + A AQ + +
Sbjct: 26872 LQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSF 26931
Query: 410 --VATIQQCQSPTNYL--QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
++ + Q +S T+ + G+ G P P + ++S EG+++ C G P+P+
Sbjct: 26932 MGISNMTQLESSTSKMLKAGIRGIP----PKIEALPSDISIDEGKVLTVACAFTGEPTPE 26987
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
V W G I R + +++ TL+I +V +D G +T + N++G+ S
Sbjct: 26988 VTWSCGGRKIHSQEQGRF------HIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 27041
Query: 526 SIAQLHVR 533
+ +H+R
Sbjct: 27042 ATVNIHIR 27049
Score = 88.6 bits (218), Expect = 4e-17
Identities = 77/327 (23%), Positives = 147/327 (44%), Gaps = 28/327 (8%)
Query: 866 KSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRL--MNEIEFRLERT 923
K+P+ + + I + +++ FS + +E + S E +L +NE L +
Sbjct: 3513 KAPESILHERIEQEIEMEMKE------FSSSFLSAEEEGLHSAELQLSKINETLELLSES 3566
Query: 924 PVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGK 983
PV + + ++ TG PIF K + + ++ G T + ++GIP PK+ WF +G
Sbjct: 3567 PVYPT--KFDSEKEGTG----PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGV 3620
Query: 984 QISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRS 1043
++ ++ K +GD SL I T +D+G YT MA+N G+ CS +L
Sbjct: 3621 LLTPSADY-KFVFDGDDH-SLIILFTKLEDEGEYTCMASNDYGKTICSAYL--------- 3669
Query: 1044 RLTSAGQSHRGRSRVQERDKEPLQERF--FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPP 1101
++ S G+ H+ + + + L++ PHFL+ + +G + V G P
Sbjct: 3670 KINSKGEGHKD-TETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPA 3728
Query: 1102 PELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P +TW + + + ++ G + +++ + D+G Y C A N G+++ + EL
Sbjct: 3729 PTVTWFKENKQLCTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAEL 3788
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHP 1188
V+ ++ + PE P
Sbjct: 3789 LVLLEDTDMTDTPCKAKSTPEAPEDFP 3815
Score = 87.8 bits (216), Expect = 6e-17
Identities = 63/213 (29%), Positives = 86/213 (40%), Gaps = 25/213 (11%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GTCSLHIESTTSDDDGNY 1017
G V F I P P V W+K G++I + K E D G L I S T+DDD Y
Sbjct: 25332 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 25391
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
T++A N G SC L V P P + RP F +
Sbjct: 25392 TVVARNKYGEDSCKAKLTVTLHP------------------------PPTDSTLRPMFKR 25427
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
+ EG+ + +VSG+PPP L W +GQP+ + +++ ++L I
Sbjct: 25428 LLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTL 25487
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK 1170
D G Y+ ATN G S L V KK
Sbjct: 25488 PEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 25520
Score = 86.7 bits (213), Expect = 1e-16
Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 9/202 (4%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR-ETGVHSL 1131
P F Q +V EG + +SG P PE++W +GQ + + + G L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I +T+ ++G Y ATN +GQ + + EL V A+ P +++LQ+ V +G VRL
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAP--PNFVQRLQSMTVRQGSQVRL 123
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ RV G+P PV + +D I + + +IS D LLI A D+G Y+++A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYS---LLIAEAYPEDSGTYSVNATN 180
Query: 1251 EAGIVSCTARLDIYAQWHHQIP 1272
G + TA ++ Q ++P
Sbjct: 181 SVGRATSTA--ELLVQGEEEVP 200
Score = 86.3 bits (212), Expect = 2e-16
Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 21/273 (7%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--DIHIVQAGNLHSLTI 328
F ++++ + EG V C + G P P++ WY +GK +++ + +Q G SL I
Sbjct: 1247 FDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRA-SLRI 1305
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEG-DPNKEEMNRIQ--KPNEVS 385
ED G Y+ FASNI G S ++Y+E + + P E ++RI+ P VS
Sbjct: 1306 PVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1365
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI--IAAPVFTKMLQN 443
P + P + A+ A+ A + SP L+ D + + PVF +
Sbjct: 1366 RSPIRMS--PARMSPARMSPARMSPARM----SPGRRLEETDESQLERLYKPVFVLKPVS 1419
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
EGQ F+ +V G P P+ W+ +G I + +++ K+ + +L+I
Sbjct: 1420 FKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-------SLIIV 1472
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
DSG +T A N+ G S L V E
Sbjct: 1473 PATPSDSGEWTVVAQNRAGRSSISVILTVEAVE 1505
Score = 85.1 bits (209), Expect = 4e-16
Identities = 98/451 (21%), Positives = 166/451 (36%), Gaps = 60/451 (13%)
Query: 193 QENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTP 252
QE + + R +V P + + V + KR ++ + + A T
Sbjct: 26270 QEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTET 26329
Query: 253 GSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG--IPPPQVRWYCEGKELE 310
+P+ P+ PP+ TQ L++ E + L C+V + +V WY +GK+L+
Sbjct: 26330 KPTPTEKVQHLPVSAPPKITQFLKAEASKEIAK--LTCVVESSVLRAKEVTWYKDGKKLK 26387
Query: 311 NSPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGD 369
+ A + L I E D G Y C S GT T+ + + S
Sbjct: 26388 ENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH---- 26443
Query: 370 PNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK 429
E++++I + + T S V P+A +
Sbjct: 26444 ---EKVSKISETKKSDQKTTESTVTRKTEPKAP--------------------------E 26474
Query: 430 PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
PI + PV LQ+ + S + F + G P P W ++G I +++ + K
Sbjct: 26475 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGG 26534
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANS 549
E I + DSG +TCT N G+VSS +L ++ +D S
Sbjct: 26535 FFLE--------IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTE-----AQKVS 26581
Query: 550 TTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFN---LPEDD 606
T + I PQ E S + L + +E +S ++ L+ + + E+
Sbjct: 26582 TQKTSEITPQKKAVVQEEIS-----QKALRSEEIKMSEAKSQEKLALKEEASKVLISEEV 26636
Query: 607 KGSEASS-EAGVVTTRQTRPDSFQERFNGQA 636
K S A+S E +V T+ E A
Sbjct: 26637 KKSAATSLEKSIVHEEITKTSQASEEVRTHA 26667
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/385 (25%), Positives = 159/385 (41%), Gaps = 73/385 (18%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GT 1001
+ P+F ++LK+ + EGS + + G P P + W K+ I +++ K+R EG G
Sbjct: 1508 VKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS-DIIVPHKYPKIRIEGTKGE 1566
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRIS--CSGHLMVQSL---PIRSRLTSAGQSHRGRS 1056
+L I+ST S D YT A N GR + C ++ V+ P R + G ++R +
Sbjct: 1567 AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRG-TYRAKE 1625
Query: 1057 RVQERDKEPLQERFFRPHFLQAPGDMVAHEG-------------RLCRL-----DCKVSG 1098
+ + EPL R+ + + + GD+ E RL R +C+++
Sbjct: 1626 -IAAPELEPLHLRYGQEQWEE--GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTP 1682
Query: 1099 LPPPELT--WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNS 1156
+ P + WL +G+P L A+ ++ E G SL RD+G C ATNK G +
Sbjct: 1683 IGDPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDH 1741
Query: 1157 FSLELSV--------------------------------------VAKEVKKAPVILEKL 1178
S L V ++ K+ P I+
Sbjct: 1742 TSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYP 1801
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ V EG R CRV G P P W + + I ++ R + D Y L I K
Sbjct: 1802 EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK-RFRVRYDGIHY--LDIVDCKS 1858
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDI 1263
D G ++A+N G++ +L+I
Sbjct: 1859 YDTGEVKVTAENPEGVIEHKVKLEI 1883
Score = 84.7 bits (208), Expect = 5e-16
Identities = 67/235 (28%), Positives = 97/235 (41%), Gaps = 16/235 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKI--VGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
P F K+L R+ P F C++ +G P V W DGK + N +M E G C
Sbjct: 1657 PFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANR-LRMINEF-GYC 1714
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL S D G T A N G S L+V+ + + +G R++E +
Sbjct: 1715 SLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELE 1774
Query: 1063 KEPL----------QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ Q+ +P + P + EG R C+V+G P P++ W LNGQ
Sbjct: 1775 RMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ- 1833
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
L S + VR G+H L I D G K A N G ++L + +E
Sbjct: 1834 -LIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRE 1887
Score = 84.3 bits (207), Expect = 7e-16
Identities = 76/282 (26%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 261 YEEPLGQPPRFTQKLRSREVPEGTRVQLDCIV--VGIPPPQVRWYCEGKELENSPDIHIV 318
Y++ Q P F +KL S + +C + +G P V W +GK LE + + ++
Sbjct: 1649 YDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI 1708
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--SDSEGDPNKEEMN 376
SL A+ D+G +C A+N YGTD TSA + ++ S +S+ ++ +
Sbjct: 1709 NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQ 1768
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ-QCQSPTNYLQGLDGKPIIAAP 435
RI++ + + H A V T Q + Q P I+ P
Sbjct: 1769 RIEE-----------------LERMAHEGALTGVTTDQKEKQKP----------DIVLYP 1801
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
++L EG+ F CRV G P PKV WY G LI S FR+ +
Sbjct: 1802 EPVRVL------EGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV---------RYD 1846
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
I L I + + D+G TA N G + +L ++ ED
Sbjct: 1847 GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRED 1888
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/120 (39%), Positives = 64/120 (53%), Gaps = 8/120 (6%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
+ P L+N++ EG+ V EC + G PSP V WYRE IE S DF+I +
Sbjct: 894 VTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ----- 948
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTT 551
I L+I E FAEDSG FTC+A N+ GTVS+ L V+ +E+ + + TT
Sbjct: 949 ---SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTT 1005
Score = 82.0 bits (201), Expect = 3e-15
Identities = 79/338 (23%), Positives = 131/338 (38%), Gaps = 46/338 (13%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L PR T ++RS VP G + V P +V+WY G EL+ S IH +
Sbjct: 25998 LDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVL 26057
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN-- 382
+L I + +D+G Y +N G S A + + G + EE+ R P
Sbjct: 26058 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT 26117
Query: 383 -----EVSSPPTTSAV-IPPAVPQAQHLVAQPR--VATIQQCQSPTNYLQGLDGKPI--- 431
VSS TS + +V + + + + R +++ + S L+ K +
Sbjct: 26118 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 26177
Query: 432 ---------IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+AA + TK ++++ EG+ F C G P P V W R+G ++ S +
Sbjct: 26178 STTRKIKTTLAARILTKP-RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ 26236
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ K +S T I+ V A D G ++ N G ++
Sbjct: 26237 VTTTKYKS--------TFEISSVQASDEGNYSVVVENS------------EGKQEAEFTL 26276
Query: 543 SLHSANSTTNLAAIEPQ---PSPPHSEPPSVEQPPKPK 577
++ A T P+ P P P +V+ P + K
Sbjct: 26277 TIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 26314
Score = 79.0 bits (193), Expect = 3e-14
Identities = 93/374 (24%), Positives = 153/374 (40%), Gaps = 67/374 (17%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
A P F + LQ+++ +G V + RV G P+P V++YR+G I+ S DF+I Q+
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQE------ 155
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED--------LSNNGSL 544
++ +L+IAE + EDSG ++ A+N G +S A+L V+G E+ + + +
Sbjct: 156 --GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213
Query: 545 HSANST------------TNLAAIE------PQPSPPHSEPPSVEQPPKPKLE-----GV 581
+ T ++A +E PH PP + PPKPK +
Sbjct: 214 SESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRI--PPKPKSRSPTPPSI 271
Query: 582 LVNHNEPRSSSRIGLR------VHFNLPEDDKGSEASSEAGVVTT--RQTRPDSFQERFN 633
R S +R H P S A + T+ R R +
Sbjct: 272 AAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQ 331
Query: 634 GQATKT-PEPSSPVKEPPPVLAKPKLDS-----TQLQQLHNQVLLE-QHQLQNPPP-SSP 685
T PE P K+ V + + + T Q+ + E ++ +Q S
Sbjct: 332 ASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGA 391
Query: 686 KEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVF 745
S++ S A AV T +K+VK + ++ ++A T A +A PV
Sbjct: 392 AGAAASVSASASYAAEAVATGAKEVKQDADKSAAVA--------TVVAAVDMARVREPV- 442
Query: 746 TLSSTPQTIQRTVS 759
+S+ QT QRT +
Sbjct: 443 -ISAVEQTAQRTTT 455
Score = 78.2 bits (191), Expect = 5e-14
Identities = 63/231 (27%), Positives = 93/231 (40%), Gaps = 16/231 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P LK+ V EG VT C I G P P V W+++ QI + G L
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDF--QITFQSGIARL 954
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ--------SLPIRSRLTSAGQSHRGRS 1056
I ++D G +T A N G +S S +L VQ + + + T+ +
Sbjct: 955 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014
Query: 1057 RVQERDKEPLQERF-----FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQ 1111
V D +E+ P+F+ P EG C+V G P P + W +G
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074
Query: 1112 PVLPDASHKMLV-RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P+ +K+ ++TG L+I DAG Y + NK G+ S S L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 77.8 bits (190), Expect = 6e-14
Identities = 70/281 (24%), Positives = 114/281 (40%), Gaps = 35/281 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSL 326
P F +KL++ + EG+R+++ G P P + W + P I I +L
Sbjct: 1510 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1569
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I +D+ Y+ A N G D+T ++ +E V ++ E
Sbjct: 1570 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE-VEFAEPE------------------- 1609
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-LDGKPIIAAPVFTKMLQNLS 445
P +IP +A+ + A P + + + +G L K P F K L +L
Sbjct: 1610 -PERKLIIPRGTYRAKEIAA-PELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1667
Query: 446 ASEGQLVVFECRVK--GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
FECR+ G P+ VEW +G +E + R++ + C+L
Sbjct: 1668 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFG--------YCSLDYG 1719
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSL 544
++ DSG TC A+NKYGT + A L V+ + L L
Sbjct: 1720 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQL 1760
Score = 75.1 bits (183), Expect = 4e-13
Identities = 83/355 (23%), Positives = 139/355 (39%), Gaps = 50/355 (14%)
Query: 820 TSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNT--KSPQPVNDDNIR 877
T I +P+ S V+ P P AP P+ K++ + +P D
Sbjct: 24431 TFGISDPLEVSSVVIIKSPFEKP--------GAPGKPTITAVTKDSCVVAWKPPASDGGA 24482
Query: 878 ETKNAVIRDLGKK------ITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDE 931
+ +N + KK +T ++R + + + + + L E + E + E
Sbjct: 24483 KIRNYYLEKREKKQNKWISVTTEEIR--ETVFSVKNLIEGLEYEFRVKCENLGGESEWSE 24540
Query: 932 IQHDEIPTGKCI--APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRN 989
I P AP F + L++ V S T CK+ G P P V W++ GK+I
Sbjct: 24541 ISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 24600
Query: 990 EHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG 1049
+++ G L I S T DD Y + A N G +S + L V+ +P + L
Sbjct: 24601 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHL---- 24655
Query: 1050 QSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
P L+ G + A G + + SG P P +TW
Sbjct: 24656 -----------------------PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITW-QK 24691
Query: 1110 GQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
GQ ++ + H ++ SL+ + + ++DAG Y A N+ G + ++EL V
Sbjct: 24692 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 24746
Score = 74.3 bits (181), Expect = 7e-13
Identities = 64/238 (26%), Positives = 107/238 (44%), Gaps = 37/238 (15%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP K +K G +C+IVG P+P + W++ GK++ + ++ KM +G T +
Sbjct: 24160 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKY-KMSSDG-RTHT 24217
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L + + +D+G YT +A N G + S L++Q+ P Q H G
Sbjct: 24218 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP---------QFHPG--------- 24259
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
PL+E+++ G RL G P P +TW +GQ +L + S + +
Sbjct: 24260 YPLKEKYY------------GAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQN-SENITI 24305
Query: 1124 RETGVHSLLIDPLTQR--DAGTYKCIATNKTGQNSFSLELSVVAKEVK-KAPVILEKL 1178
T ++ L+ QR AG YK +N G L++ + K K P+++E L
Sbjct: 24306 ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 24363
Score = 74.3 bits (181), Expect = 7e-13
Identities = 79/326 (24%), Positives = 123/326 (37%), Gaps = 44/326 (13%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + + + EG V FTC+I G P P++ WFK+ IS + R S
Sbjct: 26761 APAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR--NVYS 26818
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL---PIRSRL--TSAGQSHRGRSRV 1058
L I + + D G YTI A N +G+ S + LMV L P R + TS S +G
Sbjct: 26819 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSS 26878
Query: 1059 QE-RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA 1117
Q + QE F + M + K + + ++ +
Sbjct: 26879 QSVQMSASKQEASFSSFSSSSASSMT---------EMKFASMSAQSMS-----------S 26918
Query: 1118 SHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEK 1177
+ V + + I +TQ ++ T K + G + +++ P
Sbjct: 26919 MQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG----------IPPKIEALP----- 26963
Query: 1178 LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAK 1237
+ + EG + + C G P P W I + ++T L+I +
Sbjct: 26964 -SDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 27022
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
K D G YTLS NE G S T + I
Sbjct: 27023 KQDGGLYTLSLGNEFGSDSATVNIHI 27048
Score = 73.9 bits (180), Expect = 9e-13
Identities = 57/210 (27%), Positives = 90/210 (42%), Gaps = 8/210 (3%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA-SHKMLVRETGVHSL 1131
PHF + ++ L CKV+G P P + W G+ ++ D +++ + G H L
Sbjct: 24556 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 24615
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
+I +T DA Y+ ATN+ G S + L V P LE + G V +
Sbjct: 24616 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 24675
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ G P PV W+K + I + + + + ++ DAG+Y + AKN
Sbjct: 24676 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 24734
Query: 1252 AGIVSCTARLDIYAQWHHQIP-PPMSVRPS 1280
GI T LD+ +P PP V+ S
Sbjct: 24735 FGIDQKTVELDV-----ADVPDPPRGVKVS 24759
Score = 72.8 bits (177), Expect = 2e-12
Identities = 64/237 (27%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
M +EG+ L ++G ++ W+LNG + ++ V + +L I + RD
Sbjct: 26676 MSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 26732
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPP 1201
G CI+ K G +L++ +KE+ AP + + ++ + EG V C + G P P
Sbjct: 26733 GILTCISKTKEGIVKCQYDLTL-SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26791
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
W K+N I + +S+ + Y+ L I+ A SD+G YT+ AKN G S TA L
Sbjct: 26792 EIEWFKNNLPISIS-SNVSISRSRNVYS-LEIRNASVSDSGKYTIKAKNFRGQCSATASL 26849
Query: 1262 DIYAQWHHQIPPPMSVRPSG--SRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVE 1316
+ + + +R SG S GS +S+ + + ++ + S S+ S+ E
Sbjct: 26850 -MVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTE 26905
Score = 71.6 bits (174), Expect = 5e-12
Identities = 56/184 (30%), Positives = 86/184 (46%), Gaps = 9/184 (4%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
D V+ EG + L ++ E+ W + V D K L ++ ++L+ID + D
Sbjct: 4376 DTVSEEGDIVHLTTSITNAK--EVNWYFENKLVPSDEKFKCL-QDQNTYTLVIDKVNTED 4432
Query: 1141 -AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMP 1199
G Y C A N +G+ + S +L+VV + APVI K++ V GH + C + P
Sbjct: 4433 HQGEYVCEALNDSGKTATSAKLTVVKRA---APVIKRKIEPLEVALGHLAKFTCEIQSAP 4489
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTA 1259
F W K I ++ S+ + + + L I + D G YT A NE G VSCTA
Sbjct: 4490 NVRFQWFKAGREI-YESDKCSI-RSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 4547
Query: 1260 RLDI 1263
L +
Sbjct: 4548 TLTV 4551
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/115 (32%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 938 PTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE 997
PT + P+F + L + EG V F ++ GIP P + W KDG+ +S + ++ E
Sbjct: 25416 PTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLS-LGPNIEIIHE 25474
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSH 1052
G +LHI T +D G Y + A N G SC HL V+ L + + + + H
Sbjct: 25475 GLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEH 25529
Score = 68.6 bits (166), Expect = 4e-11
Identities = 78/309 (25%), Positives = 135/309 (43%), Gaps = 42/309 (13%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S ++LY E + F + ++ +V E R +C V P V+W + +EL+ +
Sbjct: 3000 TSTATLYVE---ARHIEFRKHIKDIKVLEKKRAMFEC-EVSEPDITVQWMKDDQELQITD 3055
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
I I + +H L I D G+Y+ A G + ++A++++EG D K+
Sbjct: 3056 RIKIQKEKYVHRLLIPSTRMSDAGKYTVVA----GGNVSTAKLFVEG---RDVRIRSIKK 3108
Query: 374 EMNRIQKPN-----EVSSPPTTS------AVIPPAVPQAQHLVAQPRV------ATIQQC 416
E+ I+K EV+ + I V + V + R+ T Q
Sbjct: 3109 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSD 3168
Query: 417 QSPTNYLQGLDGKPI---IAAPVFTKMLQNL---SASEGQLVVFECRVKGAPSPKVEWYR 470
++ G + + + AP ++LQ L + G+ F + G P PK+ WY+
Sbjct: 3169 AGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYK 3228
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
E L+ S F K + + + +E TL++ E F ED+ +TC A N YG ++ A L
Sbjct: 3229 EEQLL--STGF-----KCKFLHDGQEY-TLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3280
Query: 531 HVRGNEDLS 539
V E +S
Sbjct: 3281 SVEVPEVVS 3289
Score = 66.6 bits (161), Expect = 1e-10
Identities = 86/381 (22%), Positives = 144/381 (37%), Gaps = 77/381 (20%)
Query: 697 SNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQR 756
S A A+ T K++ A SS K + T P+ P F + TP T +
Sbjct: 787 SIAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYK- 845
Query: 757 TVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIP 816
S V+ K G+SI T T F + G + +
Sbjct: 846 ---------SEAGVEVKKEVGVSI---------TGTTVREERFEVLHGREAK-------- 879
Query: 817 VSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPR------------------SAPSMP-- 856
V+ T+R+ PV +P PPT GL +P++
Sbjct: 880 VTETARVPAPV--------EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 931
Query: 857 ----------------SQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT--FSDVRP 898
G+A+ + + +D+ R T +AV + G T + V+
Sbjct: 932 REDYQIESSIDFQITFQSGIARLMIR--EAFAEDSGRFTCSAV-NEAGTVSTSCYLAVQV 988
Query: 899 NQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVT 957
+++ E + ++ ++ E + +E V +D + ++ G+ AP F + ++
Sbjct: 989 SEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV 1048
Query: 958 EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
EG V F C++ G P P VYW K G ++ + + G C L I T +DD G Y
Sbjct: 1049 EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEY 1108
Query: 1018 TIMAANPQGRISCSGHLMVQS 1038
TI+ N G S S L+ ++
Sbjct: 1109 TIVVRNKHGETSASASLLEEA 1129
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 243 SEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
+E G + P + S+ + G+ P ++++ G QL C +VG P P ++W
Sbjct: 24135 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 24194
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
Y GKEL S + G H+LT+ +ED G Y+C A+N G TS+++ ++ +
Sbjct: 24195 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ-AT 24253
Query: 363 SSDSEGDPNKEE 374
G P KE+
Sbjct: 24254 PQFHPGYPLKEK 24265
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/113 (32%), Positives = 57/113 (50%), Gaps = 1/113 (0%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-NLHSLT 327
P F + L + E EG V + V GIPPP ++W +G+ L P+I I+ G + ++L
Sbjct: 25423 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25482
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
I + EDTG Y A+N G+ S A + +E + E +E +QK
Sbjct: 25483 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEHERHVQK 25535
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 1052 HRGRSRVQE--RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
H ++V E R P++ P + ++ EG L+C +SG P P +TW
Sbjct: 874 HGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRE 933
Query: 1110 GQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEV 1168
+ ++ ++G+ L+I D+G + C A N+ G S S L+V V++E
Sbjct: 934 DYQIESSIDFQITF-QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF 992
Query: 1169 KK----------------------------------------APVILEKLQNCGVPEGHP 1188
+K AP + K + EG
Sbjct: 993 EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGS 1052
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCT---RERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
V C+V G P P YWKK +P T R ++S ++ TG L+I DAG YT
Sbjct: 1053 VVFGCQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQ-TGECKLVISMTFADDAGEYT 1109
Query: 1246 LSAKNEAGIVSCTARL 1261
+ +N+ G S +A L
Sbjct: 1110 IVVRNKHGETSASASL 1125
Score = 65.5 bits (158), Expect = 3e-10
Identities = 63/268 (23%), Positives = 95/268 (35%), Gaps = 68/268 (25%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP FT L ++ G V+ + P P V WY G++++ N
Sbjct: 25314 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIK--------PGDNDK 25365
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
T FE D G Y +++ D + DS K ++ P
Sbjct: 25366 KYT----FESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDS----CKAKLTVTLHP--- 25414
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
PPT S + P+F ++L N
Sbjct: 25415 --PPTDSTL----------------------------------------RPMFKRLLANA 25432
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
EGQ V FE RV G P P ++W ++G + P+ I+ E + L I +
Sbjct: 25433 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIH-------EGLDYYALHIRD 25485
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
ED+G + TA+N G+ S A L V
Sbjct: 25486 TLPEDTGYYRVTATNTAGSTSCQAHLQV 25513
Score = 64.7 bits (156), Expect = 6e-10
Identities = 52/211 (24%), Positives = 86/211 (40%), Gaps = 10/211 (4%)
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
+V W+KDGK++ K N H + DGT L I + T D G Y + G +
Sbjct: 26376 EVTWYKDGKKL-KENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQF 26434
Query: 1035 MVQSL-PIRSRLTSAGQSHRGRSRVQE----RDKEPL--QERFFRPHFLQAPGDMVAHEG 1087
M Q+ I +++ ++ + + E R EP + +P + D
Sbjct: 26435 MGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSD 26494
Query: 1088 RLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCI 1147
+ + K +G P P W +G+ + +K L + G L I D+G Y C
Sbjct: 26495 SVAKFAVKATGEPRPTAIWTKDGKAITQGGKYK-LSEDKGGFFLEIHKTDTSDSGLYTCT 26553
Query: 1148 ATNKTGQNSFSLELSVVA-KEVKKAPVILEK 1177
N G S S +L++ A K+ + V +K
Sbjct: 26554 VKNSAGSVSSSCKLTIKAIKDTEAQKVSTQK 26584
Score = 63.5 bits (153), Expect = 1e-09
Identities = 62/255 (24%), Positives = 104/255 (40%), Gaps = 44/255 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP +R++ V +GS F ++VG P P+ W+K+G +I +R++ D C
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI-ERSDRIYWYWPEDNVCE 2089
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I T++D + + A N G S L+VQ+ + +
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLIT-------------------- 2129
Query: 1064 EPLQERFFRPHFLQAPGDMVAHE-GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F Q D+VA E + +C+ S P ++ W +G V ++M
Sbjct: 2130 -----------FTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDGMEVHEGDKYRM- 2176
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQN 1180
+ VH L I + DA Y C+ + AK + + V+ +++LQ+
Sbjct: 2177 HSDRKVHFLSILTIDTSDAEDYSCVLVEDE-------NVKTTAKLIVEGAVVEFVKELQD 2229
Query: 1181 CGVPEGHPVRLECRV 1195
VPE + LEC V
Sbjct: 2230 IEVPESYSGELECIV 2244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 51/252 (20%)
Query: 282 EGTRVQLDCIVVGIPPP-QVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
EG V+ C + QV WY ++LENS I + L + + + D G Y
Sbjct: 25209 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYR 25268
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C N YG DS+ AE++++GV + + M +I++
Sbjct: 25269 CKVVNDYGEDSSYAELFVKGV--REVYDYYCRRTMKKIKR-------------------- 25306
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
R T++ + P P FT L N +A G+ V F +
Sbjct: 25307 --------RTDTMRLLERP---------------PEFTLPLYNKTAYVGENVRFGVTITV 25343
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P P V WY+ G I+ + K + + + L I V +D +T A NK
Sbjct: 25344 HPEPHVTWYKSGQKIKPGDN-----DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 25398
Query: 521 YGTVSSIAQLHV 532
YG S A+L V
Sbjct: 25399 YGEDSCKAKLTV 25410
Score = 62.0 bits (149), Expect = 4e-09
Identities = 76/296 (25%), Positives = 112/296 (37%), Gaps = 61/296 (20%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
AAPV + ++ L + G L F C ++ AP+ + +W++ G I +S I K
Sbjct: 4460 AAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSK----- 4514
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTN 552
I +L I D G +TC ASN+YG+VS A L V ++
Sbjct: 4515 ---YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV----------TVPGGEKKVR 4561
Query: 553 LAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEAS 612
E +P P +P+ E V EP+ ++ P E
Sbjct: 4562 KLLPERKPEPKEEVVLKSVLRKRPEEEEPKV---EPKKLEKVKKPAVPEPPPPKPVEEV- 4617
Query: 613 SEAGVVTTRQTRPDSFQERFNGQATKTPE--PSSPVKEPPPVLAKPKLDSTQLQQLHNQV 670
E VT R ER + TK PE P+ P+ P P KPK ++
Sbjct: 4618 -EVPTVTKR--------ERKIPEPTKVPEIKPAIPLPAPEP---KPKPEA---------- 4655
Query: 671 LLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSK--QVKAPSSQTFSLARPK 724
+ + PPP P+ P + AP V K + KAP + A+PK
Sbjct: 4656 ---EVKTIKPPPVEPEPTPIA-------APVTVPVVGKKAEAKAPKEEA---AKPK 4698
Score = 60.8 bits (146), Expect = 8e-09
Identities = 81/357 (22%), Positives = 127/357 (35%), Gaps = 67/357 (18%)
Query: 266 GQP--PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV---QA 320
G+P P F K +++ EG V C V G P P V W G L + Q
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQT 1090
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG----VSSSDSEGDPNKEEMN 376
G L I+ F +D G Y+ N +G S SA + E + S E +
Sbjct: 1091 GEC-KLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTA 1149
Query: 377 RIQKPNEVSSPP-----------------------TTSAVIPPAVPQAQHLVAQPRVATI 413
+Q+P + P + V+ V + ++ I
Sbjct: 1150 FVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLI 1209
Query: 414 QQCQ-----SPTNYLQGLDGKPIIAAPV---------FTKMLQNLSASEGQLVVFECRVK 459
++ + + L DG+ +A + F ++N EG V F C++
Sbjct: 1210 KEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMS 1269
Query: 460 GAPSPKVEWYREGTLIEDSPDFRI--LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
G P PK+ WY++G I+ +++ LQ S+ P V ED G +T A
Sbjct: 1270 GYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIP---------VVLPEDEGIYTAFA 1320
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
SN G +L+V L + T + +EP P SV + P
Sbjct: 1321 SNIKGNAICSGKLYVEPAAPL---------GAPTYIPTLEPVSRIRSLSPRSVSRSP 1368
Score = 60.8 bits (146), Expect = 8e-09
Identities = 85/347 (24%), Positives = 134/347 (38%), Gaps = 61/347 (17%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
RV EG F C++ G P PKV W+ +G+ I K + R DG L I S D
Sbjct: 1805 RVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK---RFRVRYDGIHYLDIVDCKSYDT 1861
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G + A NP+G I L +Q Q RS V R EP RP
Sbjct: 1862 GEVKVTAENPEGVIEHKVKLEIQ------------QREDFRS-VLRRAPEP------RPE 1902
Query: 1075 F-LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV----LPDASHKMLVR----- 1124
F + PG + + + ++D V E+ L + + +P+ S ++ +
Sbjct: 1903 FHVHEPGKL---QFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRT 1959
Query: 1125 ETGVHSLLID---PLTQRDAGTYKCIATNKTGQNSFSLELS-----VVAKEVK------- 1169
E G + + ++D + + K ++ EL+ +A+E K
Sbjct: 1960 EEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFK 2019
Query: 1170 ----------KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+AP I E++Q+ V +G RV+G P P W K+ I +RI
Sbjct: 2020 PDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRI 2078
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ L+I+ D+ + A N AG S A L + A+
Sbjct: 2079 YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2125
Score = 60.8 bits (146), Expect = 8e-09
Identities = 82/331 (24%), Positives = 126/331 (38%), Gaps = 67/331 (20%)
Query: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
D+S E+ E PT F + L+ VTE F+C++ V W+++G++I
Sbjct: 6438 DKSVAELLIIEAPTE------FVEHLEDQTVTEFDDAVFSCQL-SREKANVKWYRNGREI 6490
Query: 986 SKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
E K + E DG+ L I+ DD+ Y + + R L V+ +P+
Sbjct: 6491 K---EGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSR----ARLFVEEIPVE-- 6541
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERFFRP--HFLQAPGDMVAHEGRLCRLDCKVSGLPPP 1102
RP L+APG V L +
Sbjct: 6542 -------------------------IIRPPQDILEAPGADVVFLAELNK--------DKV 6568
Query: 1103 ELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELS 1162
E+ WL N V+ H+M+ E +H L I + RD G Y+ IA +K +
Sbjct: 6569 EVQWLRNNMVVVQGDKHQMM-SEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKL----- 6622
Query: 1163 VVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
E+ AP I Q+ V G P+ + P W K+NE P + + I
Sbjct: 6623 ----ELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENE--PLSTKTIDTT 6676
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ T + L AKK D G Y + +N+ G
Sbjct: 6677 AEQTSFRIL---EAKKGDKGRYKIVLQNKHG 6704
Score = 60.5 bits (145), Expect = 1e-08
Identities = 145/725 (20%), Positives = 229/725 (31%), Gaps = 133/725 (18%)
Query: 365 DSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
D+E E R + P+ VSS + S A + A Q S Y +
Sbjct: 25931 DTERRSPTPERTRPRSPSPVSSERSLSRFERSARFDIFSRYESMKAALKTQKTSERKY-E 25989
Query: 425 GLDGKPIIA--APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
L +P AP T +++ GQ F V+ P+ +V+WY G +++S
Sbjct: 25990 VLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH 26049
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ TL I + +DSG + +N G S A L V G +
Sbjct: 26050 Y--------TNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGD------ 26095
Query: 543 SLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNL 602
T A+ P S P + + + SSS ++
Sbjct: 26096 -------YTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTE 26148
Query: 603 PEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQ 662
+ S S + + + S +E+ + KT + +L KP+
Sbjct: 26149 TRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR-------ILTKPR----- 26196
Query: 663 LQQLHNQVLLEQHQLQNPPPSSPKEFPFSM-----TVLNSNAPPAVTTSSKQVKAPSSQT 717
+ + E + + + P VL+++A VTT+ + S
Sbjct: 26197 -----SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 26251
Query: 718 FSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGG 777
+ Y N+ A FTL TIQ+ E + S P V++ P
Sbjct: 26252 QASDEGNYSVVVENSEGKQEAE-----FTL-----TIQKARVTEKAVTSPPRVKSPEPRV 26301
Query: 778 LSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSL 837
S + P P P P+ VSP PT
Sbjct: 26302 KSPEAVKSPKRVKSPEPS------------HPKAVSPTETKPT----------------- 26332
Query: 838 PAIPPTNAMGLPRSAPSMPSQGL---AKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT-- 892
P LP SAP +Q L A K V + ++ K GKK+
Sbjct: 26333 ---PTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKEN 26389
Query: 893 ----FSDVRPNQQEYKISSFEQRLMNEI--------------------EFRLERTPVDES 928
F E KI++ + E F+ V +
Sbjct: 26390 GHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 26449
Query: 929 DDEIQHDEIPTGKCIA--------------PIFDKRLKHFRVTEGSPVTFTCKIVGIPVP 974
+ + D+ T + P+ L+ V+ S F K G P P
Sbjct: 26450 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 26509
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
W KDGK I++ ++ E G L I T + D G YT N G +S S L
Sbjct: 26510 TAIWTKDGKAITQGGKY--KLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 26567
Query: 1035 MVQSL 1039
++++
Sbjct: 26568 TIKAI 26572
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT ++ P + AP + +Q+ + +G F RV G P P+ EWY+ G IE S
Sbjct: 2016 PTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERS 2075
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
RI P + +C LVI +V AEDS A N G SS A L V+ + +
Sbjct: 2076 D--RIYWYWPE-----DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLI 2128
Query: 539 SNNGSLHS--ANSTTNLAAIEPQPSPP 563
+ L A +A E + S P
Sbjct: 2129 TFTQELQDVVAKEKDTMATFECETSEP 2155
Score = 58.9 bits (141), Expect = 3e-08
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 16/147 (10%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG----VPE 1185
S L++ L + ++ A N+ G++ SL L+VV ++ + P I +L G V
Sbjct: 8981 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 9040
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETI--------PCTRERISMHQDTTGYACLLIQPAK 1237
G PV + V G+P P W K NET+ T+E +S + T L I A
Sbjct: 9041 GEPVHIPADVTGLPMPKIEWSK-NETVIEKPTDALQITKEEVSRSEAKTE---LSIPKAV 9096
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDIY 1264
+ D G YT++A N G V +++Y
Sbjct: 9097 REDKGTYTVTASNRLGSVFRNVHVEVY 9123
Score = 58.2 bits (139), Expect = 5e-08
Identities = 40/128 (31%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
K AP+ ++++ V G FTC+I P + WFK G++I + ++ C + R
Sbjct: 4458 KRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE-SDKCSI-RSSKY 4515
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
SL I T D G YT A+N G +SC+ L V T G + R + E
Sbjct: 4516 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV---------TVPGGEKKVRKLLPE 4566
Query: 1061 RDKEPLQE 1068
R EP +E
Sbjct: 4567 RKPEPKEE 4574
Score = 57.8 bits (138), Expect = 7e-08
Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F +RL+ V +GS V ++ GIP P V +++DG +I + ++ +EGD SL
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDF-QISQEGD-LYSL 161
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ---SLPIRSRLTSAGQSHRGRSRVQER 1061
I +D G Y++ A N GR + + L+VQ +P + T + SR Q R
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESR-QTR 220
Query: 1062 DKEPLQERF 1070
++ ++ F
Sbjct: 221 IEKKIEAHF 229
Score = 56.6 bits (135), Expect = 2e-07
Identities = 52/196 (26%), Positives = 80/196 (40%), Gaps = 19/196 (9%)
Query: 849 PRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSF 908
PRS P QG + + +P D R K T S + N E+++ F
Sbjct: 8946 PRSNGGSPIQGYIIEKRRHDKP---DFERVNKRLCP-------TTSFLVENLDEHQMYEF 8995
Query: 909 EQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKI 968
+ +NEI E P + IQ DE+P I R +V G PV +
Sbjct: 8996 RVKAVNEIG---ESEPSLPLNVVIQDDEVPP--TIKLRLSVRGDTIKVKAGEPVHIPADV 9050
Query: 969 VGIPVPKVYWFKDGKQISKRNEHCKMRRE----GDGTCSLHIESTTSDDDGNYTIMAANP 1024
G+P+PK+ W K+ I K + ++ +E + L I +D G YT+ A+N
Sbjct: 9051 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNR 9110
Query: 1025 QGRISCSGHLMVQSLP 1040
G + + H+ V P
Sbjct: 9111 LGSVFRNVHVEVYDRP 9126
Score = 56.6 bits (135), Expect = 2e-07
Identities = 105/539 (19%), Positives = 201/539 (37%), Gaps = 76/539 (14%)
Query: 74 ESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQ 133
+ + A+ P K+ E + + SP+ +K SP P SPT +K +P
Sbjct: 26279 QKARVTEKAVTSPPRVKSPEPRVK---SPEAVK-SPKRVKSPEPSHPKAVSPTETKPTPT 26334
Query: 134 EAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKS-KLESQNKVM 192
E + Q+ + K+ A+ +E++ L S +R + +K K +N
Sbjct: 26335 E--KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHF 26392
Query: 193 QENSSS-------FSDLSERRERSSVPIPIPADTRDNEVN--------HALEQQEAKRRE 237
Q + S+ ++L+E + V I + ++ N ++ ++ +K E
Sbjct: 26393 QFHYSADGTYELKINNLTESDQGEYV-CEISGEGGTSKTNLQFMGQAFKSIHEKVSKISE 26451
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPP 297
+++ + T + P + EP+ P L+ V + + G P
Sbjct: 26452 TKKSDQKTTESTVTRKTEPKA---PEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPR 26508
Query: 298 PQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIY 357
P W +GK + + + L I + D+G Y+C N G+ S+S ++
Sbjct: 26509 PTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLT 26568
Query: 358 IEGVSSSD---------SEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQP 408
I+ + ++ SE P K+ + + E+S S I + ++Q +A
Sbjct: 26569 IKAIKDTEAQKVSTQKTSEITPQKKAVVQ----EEISQKALRSEEIKMSEAKSQEKLALK 26624
Query: 409 RVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ----------------NLSASEGQLV 452
A+ + I TK Q +S +EGQ +
Sbjct: 26625 EEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 26684
Query: 453 VFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGC 512
V + + GA V+W G + +S ++R ++ ++ TL I + D G
Sbjct: 26685 VLKANIAGATD--VKWVLNGVELTNSEEYRY------GVSGSDQ--TLTIKQASHRDEGI 26734
Query: 513 FTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL---------AAIEPQPSP 562
TC + K G V Q + +++LS+ + S + N+ I +PSP
Sbjct: 26735 LTCISKTKEGIVK--CQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26791
Score = 55.8 bits (133), Expect = 3e-07
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 48/323 (14%)
Query: 59 DLPDLSAFLSQ---EELDESVN-LARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFE 114
+L D AF+SQ + ++E N L I+ +P + E + K P + + ++S
Sbjct: 26757 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEP---SPEIEWFKNNLPISISSNVSISRS 26813
Query: 115 PNFCQDNPRSPTSSKESPQEAKRPQY---CSETQS-----------KKVFLNKAADFIEE 160
N R+ + S K + CS T S ++V L + D
Sbjct: 26814 RNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGD---- 26869
Query: 161 LSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTR 220
+SL S SS+ ++ A K S +SSS S ++E + S
Sbjct: 26870 -TSLQGSFSSQSVQMSASKQEAS-------FSSFSSSSASSMTEMKFASMSA-------- 26913
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
++ + E ++ T SS S + G PP+ +
Sbjct: 26914 -----QSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISI 26968
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD--IHIVQAGNLHSLTIAEAFEEDTGR 338
EG + + C G P P+V W C G+++ + HI +L +L I + ++D G
Sbjct: 26969 DEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGL 27028
Query: 339 YSCFASNIYGTDSTSAEIYIEGV 361
Y+ N +G+DS + I+I +
Sbjct: 27029 YTLSLGNEFGSDSATVNIHIRSI 27051
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 2/95 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENS--PDIHIVQAGNLH 324
Q P FTQ L+S V EG+ + + G P P+V W+ +G+ + S P + I +
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
LTI + ++GRYS A+N G +++AE+ ++
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/149 (28%), Positives = 69/149 (46%), Gaps = 10/149 (6%)
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
HK ++ET ++D + ++ N+ G++ + VV KE + PV+ KL
Sbjct: 11779 HKGSIKET---HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKL 11835
Query: 1179 QNC-GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE---RISMHQDTTGYACLLIQ 1234
V G +RLE V G P P W KD + TR +I D++ ++ +
Sbjct: 11836 SGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS---LT 11892
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
AK+SD G Y ++A N AG A +++
Sbjct: 11893 KAKRSDGGKYVVTATNTAGSFVAYATVNV 11921
Score = 55.1 bits (131), Expect = 4e-07
Identities = 64/280 (22%), Positives = 107/280 (38%), Gaps = 33/280 (11%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T+ +++ EVPE +C V P + W G E+E S IV G LH L I
Sbjct: 2839 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNT 2897
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
ED+ Y+ + G D SA + + + + D N EE + I V+ +
Sbjct: 2898 STEDSAEYTF----VCGNDQVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISY 2953
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-------LDGKPIIAAPV-------- 436
+ V Q R + + N G + GK A +
Sbjct: 2954 KWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIE 3013
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
F K ++++ E + +FEC V P V+W ++ ++ + +I ++K
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEK--------Y 3064
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ L+I D+G +T A T A+L V G +
Sbjct: 3065 VHRLLIPSTRMSDAGKYTVVAGGNVST----AKLFVEGRD 3100
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACL 1231
P ++ L+N V EG V LEC + G P P W +++ I + + Q +G A L
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ--SGIARL 954
Query: 1232 LIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+I+ A D+G +T SA NEAG VS + L +
Sbjct: 955 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 986
Score = 54.3 bits (129), Expect = 8e-07
Identities = 78/382 (20%), Positives = 141/382 (36%), Gaps = 55/382 (14%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS--PDFRILQKKPRSM 491
AP FT+ LQ++ EG FE + G P P+V W+R+G +I S P +I R+
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA- 63
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN------NGSLH 545
L I V +SG ++ A+N G +S A+L V+ N + ++
Sbjct: 64 -------KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVR 116
Query: 546 SANSTTNLAAIEPQPSPP---HSEPPSVEQ------PPKPKLEGVLVNHNEPRSSSRIGL 596
+ + P+P + + ++ + L +L+ P S +
Sbjct: 117 QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 597 RVHFNLPEDDKGSE----------------ASSEAGVVTTRQTRPD-SFQERFNGQATKT 639
++ +E S A + +RQTR + + F+ ++ T
Sbjct: 177 NATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT 236
Query: 640 PE--------PSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFS 691
E P K PP + KPK S + + L + Q PS + P
Sbjct: 237 VEMVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQ----SPSPIRHSPSP 292
Query: 692 MTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTP 751
+ + + P V + S + +S S+ P + +T AT P P +
Sbjct: 293 VRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVAT-GPEVPPPWKQEGYV 351
Query: 752 QTIQRTVSKESLLVSHPSVQTK 773
+ +E+ L + ++T+
Sbjct: 352 ASSSEAEMRETTLTTSTQIRTE 373
Score = 53.1 bits (126), Expect = 2e-06
Identities = 68/307 (22%), Positives = 117/307 (38%), Gaps = 39/307 (12%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H L ++ K +A + A T ++L+ +EP P FT+ L + V EG
Sbjct: 5878 HTLTLRDVKLEDAGEVQLTAKDFKTH-----ANLFVKEP---PVEFTKPLEDQTVEEGAT 5929
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+C V +V+W+ G E+ S IV G + L I + ED Y+C A +
Sbjct: 5930 AVLEC-EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 5988
Query: 346 I--------------YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
+ T ++ + ++ + E ++ + E+
Sbjct: 5989 FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYD 6048
Query: 392 AVIPPAVPQAQHLVAQPRVATIQ---QCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+ AV + LV + + C+ T G+ + VFTK L N+ SE
Sbjct: 6049 IISKGAV---RILVINKCLLDDEAEYSCEVRTARTSGM-LTVLEEEAVFTKNLANIEVSE 6104
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C V P +V WY+ I ++ + IL + + + LVI E
Sbjct: 6105 TDTIKLVCEV-SKPGAEVIWYKGDEEIIETGRYEILTEGRKRI--------LVIQNAHLE 6155
Query: 509 DSGCFTC 515
D+G + C
Sbjct: 6156 DAGNYNC 6162
Score = 53.1 bits (126), Expect = 2e-06
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 4/128 (3%)
Query: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV---PEGTR 285
E E +R E A AA + P S + ++ + +PPR ++ R+V G
Sbjct: 19376 ELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV-EPPRVMMDVKFRDVIVVKAGEV 19434
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
++++ + G P P + W +G E+E I+ N LT+ + DTG+Y N
Sbjct: 19435 LKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKN 19494
Query: 346 IYGTDSTS 353
+ GT S +
Sbjct: 19495 VAGTRSVA 19502
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG 294
R + E E+ + + +P S + P+ Q P F ++LR+ V + L C V G
Sbjct: 24526 RVKCENLGGESEWSEISEPITPKS---DVPI-QAPHFKEELRNLNVRYQSNATLVCKVTG 24581
Query: 295 IPPPQVRWYCEGKELENSPDIHIVQ--AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P V+WY +GKE+ + +Q G H L IA ++D Y A+N G+ S
Sbjct: 24582 HPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSG 24641
Query: 353 SAEIYIE 359
+A + +E
Sbjct: 24642 TASLEVE 24648
Score = 52.4 bits (124), Expect = 3e-06
Identities = 71/307 (23%), Positives = 109/307 (35%), Gaps = 63/307 (20%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K LK+ VTE FT ++ V V W K+G + + NE + +G SL I++
Sbjct: 2665 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGV-VLESNEKYAISVKGT-IYSLRIKN 2722
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
D+ Y GR+ S L V+++ I
Sbjct: 2723 CAIVDESVYGFRL----GRLGASARLHVETVKI--------------------------- 2751
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ P D+ A E + VS P + W + P H+ LV E V
Sbjct: 2752 -------IKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHR-LVSERKV 2802
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
H L++ ++ DAG Y + GQ +L V + K ++N VPE
Sbjct: 2803 HKLMLQNISPSDAGEYTAV----VGQLECKAKLFVETLHITKT------MKNIEVPETKT 2852
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQPAKKSDAGWY 1244
EC V P + K E + +I +HQ L+I D+ Y
Sbjct: 2853 ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQ-------LIIMNTSTEDSAEY 2905
Query: 1245 TLSAKNE 1251
T N+
Sbjct: 2906 TFVCGND 2912
Score = 52.4 bits (124), Expect = 3e-06
Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 11/138 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRF---TQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
A G++ P P + ++ L +PP R + + G ++L I+ G+P P+V W
Sbjct: 10822 AAGESDPAHVPEPVLVKDRL-EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW 10880
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
E ++ I + G+ L I A ED G YS N G+ + S ++ +
Sbjct: 10881 KKEDRDAPTKARIDVTPVGS--KLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLV---- 10934
Query: 363 SSDSEGDPNKEEMNRIQK 380
D G P E++ I+K
Sbjct: 10935 -LDKPGPPRDLEVSEIRK 10951
Score = 52.4 bits (124), Expect = 3e-06
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVILEKLQN 1180
+V E+ V + ++ L+ ++ A N+ G++ L + V+AK++ P +
Sbjct: 17889 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 17948
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
+ G +++E VIG P P W KD E + T R+++ + T L I+ K D
Sbjct: 17949 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQT-TRVNVEETATS-TVLHIKEGNKDD 18006
Query: 1241 AGWYTLSAKNEAG 1253
G YT++A N AG
Sbjct: 18007 FGKYTVTATNSAG 18019
Score = 52.0 bits (123), Expect = 4e-06
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP K +++++ G+ C++ G P P ++WYR G ++Q + M+
Sbjct: 24160 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGK--------ELIQSRKYKMSS 24211
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
TL + ED G +TC A+N+ G V + ++L
Sbjct: 24212 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 24248
Score = 52.0 bits (123), Expect = 4e-06
Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRS 490
I AP F + L+NL+ C+V G P P V+WYR+G +I D +RI + K
Sbjct: 24553 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFK--- 24609
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L+IA V +D+ + A+N+ G+VS A L V
Sbjct: 24610 ----GGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24647
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/135 (30%), Positives = 66/135 (48%), Gaps = 14/135 (10%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP-------EGHP 1188
LT+ T++ A N+ G+ + S E++VVA++ AP + K G+P E
Sbjct: 13573 LTEGKEYTFRVSAENENGEGTPS-EITVVARDDVVAPDLDLK----GLPDLCYLAKENSN 13627
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
RL+ + G P P WKK + + T R+S+ L++ +KSDAG YT++
Sbjct: 13628 FRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAVN-TTLIVYDCQKSDAGKYTITL 13685
Query: 1249 KNEAGIVSCTARLDI 1263
KN AG T + +
Sbjct: 13686 KNVAGTKEGTISIKV 13700
Score = 51.2 bits (121), Expect = 6e-06
Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 18/187 (9%)
Query: 215 IPAD--TRDNEVNHALEQQEAKRREAEQAAS------EAAGGDTTPGSSPSSLYYEEPLG 266
+P D R N H + Q+E E+ A + +P S PS
Sbjct: 12859 LPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAEN 12918
Query: 267 QPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PPR + + V GT V LD V G P P V W +G L+ + I + NL
Sbjct: 12919 VPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL 12978
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
+L + +D+G Y+ A N G+ S + ++ + D G P ++N++
Sbjct: 12979 CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV-----LDKPGPPASVKINKMYSDRA 13033
Query: 384 VSS--PP 388
+ S PP
Sbjct: 13034 MLSWEPP 13040
Score = 51.2 bits (121), Expect = 6e-06
Identities = 27/87 (31%), Positives = 41/87 (47%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T ++ VP G V+L + G PPP W+ G +L S + + + LTI E
Sbjct: 23370 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET 23429
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYI 358
DTG Y+ N+ GT S + ++ I
Sbjct: 23430 TIRDTGEYTLELKNVTGTTSETIKVII 23456
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 8/89 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
L+ G V + V G P P V W ++GTL++ + + MA +CTL +
Sbjct: 12933 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK--------MAMQRNLCTLELF 12984
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
V +DSG +T TA N G+ S+ +L V
Sbjct: 12985 SVNRKDSGDYTITAENSSGSKSATIKLKV 13013
Score = 50.1 bits (118), Expect = 1e-05
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVR 1190
+I LTQ + ++ +A N+ G++ SL + +VAK++ P + + V G ++
Sbjct: 16817 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 16876
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E + G P P W KD + T RI++ D+ L I+ K D G Y ++ N
Sbjct: 16877 IEVPISGRPKPTITWTKDGLPLKQT-TRINV-TDSLDLTTLSIKETHKDDGGQYGITVAN 16934
Query: 1251 EAG 1253
G
Sbjct: 16935 VVG 16937
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 14/144 (9%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV-----ILEKLQNCGVPEGHPVR 1190
LT+ + T++ +A N G+++ V+ KE P I +KL G ++
Sbjct: 14655 LTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--GDNIK 14712
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E V+G P P WKK ++ + T +R++ T L I +SD+G Y L+A+N
Sbjct: 14713 VEIPVLGRPKPTVTWKKGDQILKQT-QRVNFETTATS-TILNINECVRSDSGPYPLTARN 14770
Query: 1251 EAGIVSCTARLDIYAQWHHQIPPP 1274
G V D+ H IP P
Sbjct: 14771 IVGEVG-----DVITIQVHDIPGP 14789
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/295 (24%), Positives = 113/295 (38%), Gaps = 55/295 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDD 1013
+V EG V K+ V V W KDG+++ + H + ++ L IE T +D
Sbjct: 2320 KVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRVHIVIDKQSH---MLLIEDMTKED 2375
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
GNY+ P +S SG + V S+ + + L
Sbjct: 2376 AGNYSFTI--PALGLSTSGRVSVYSVDVITPLK--------------------------- 2406
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
D+ EG L+CKVS + W LN + + PD + +V+ T L+I
Sbjct: 2407 -------DVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT-KQRLVI 2458
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ D G YK I G+ + LSV +++K I+ L++ E V E
Sbjct: 2459 NRTHASDEGPYKLI----VGRVETNCNLSV--EKIK----IIRGLRDLTCTETQNVVFEV 2508
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+ V + KD E P ++ +I H L + K D G YT A
Sbjct: 2509 ELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYK---LTVLNMMKDDEGKYTFYA 2560
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 54/300 (18%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K +K+ V E +F C++ VP + W K+G +I + +E K+ +G L I +
Sbjct: 2840 KTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEI-EMSEKFKIVVQGK-LHQLIIMN 2896
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
T+++D YT + N Q S L V + I S L +E+D +
Sbjct: 2897 TSTEDSAEYTFVCGNDQ----VSATLTVTPIMITSMLKDI--------NAEEKDTITFEV 2944
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
V +EG WL NG + +M ++
Sbjct: 2945 -------------TVNYEG--------------ISYKWLKNGVEIKSTDKCQMRTKKL-T 2976
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
HSL I + DA Y +A G+ + + L V A+ ++ + +++ V E
Sbjct: 2977 HSLNIRNVHFGDAADYTFVA----GKATSTATLYVEARHIE----FRKHIKDIKVLEKKR 3028
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
EC V P W KD++ + T +RI + ++ + LLI + SDAG YT+ A
Sbjct: 3029 AMFECEV-SEPDITVQWMKDDQELQIT-DRIKIQKEKYVHR-LLIPSTRMSDAGKYTVVA 3085
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/229 (27%), Positives = 91/229 (39%), Gaps = 43/229 (18%)
Query: 844 NAMGLPRSAPSMPSQGLAKKNTKSPQPVND--DNIRETK----NAVIRDLGKKIT----- 892
N+ GL S+PS PS+ + P D D RET N +RD G KI
Sbjct: 21463 NSAGL--SSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE 21520
Query: 893 ------------FSDVRPNQQEYKISSFEQRLMNEIEFRL-ERTPVDESDDEIQHDEI-- 937
F+DV ++ +Y ++ + EFR+ R V Q I
Sbjct: 21521 KRQGNERWVRCNFTDV--SECQYTVTGLSPG--DRYEFRIIARNAVGTISPPSQSSGIIM 21576
Query: 938 PTGKCIAPIFDKRLKHFR---VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKM 994
+ + PI + ++F + G + + G PVP+V WFKDG +I KR M
Sbjct: 21577 TRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR-----M 21631
Query: 995 RREGD---GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
E G+ SL + T D G YT+ A N G + VQ P
Sbjct: 21632 NMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 21680
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 8/126 (6%)
Query: 1143 TYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
+++ A N G + +S ++ + E+ + + + + G +RL V G
Sbjct: 23042 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGR 23101
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
PPPV W K + ++ T Y+ L++ + DAG YT+ A+N++G S T
Sbjct: 23102 PPPVITWSKQGIDLASR----AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSAT 23157
Query: 1259 ARLDIY 1264
+ +Y
Sbjct: 23158 VLVKVY 23163
Score = 48.9 bits (115), Expect = 3e-05
Identities = 42/185 (22%), Positives = 74/185 (40%), Gaps = 13/185 (7%)
Query: 187 SQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRR---------- 236
+ KV +E+ S R E + + + + + E+ K +
Sbjct: 1940 THEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKEL 1999
Query: 237 -EAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
E E+ A G T P P + P + P+ ++++S+ V +G+ VVG
Sbjct: 2000 TEEEKKALAEEGKITIPTFKPDKIELS-PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGK 2058
Query: 296 PPPQVRWYCEGKELENSPDIH-IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P+ WY G ++E S I+ N+ L I + ED+ A NI G S+ A
Sbjct: 2059 PDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHA 2118
Query: 355 EIYIE 359
+ ++
Sbjct: 2119 FLLVQ 2123
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E R E A AAG + P S ++ + + PPR + + ++ V G ++
Sbjct: 16133 EDHRYEFRVIARNAAGVFSEPSESTGAITARDEV-DPPRISMDPKYKDTIVVHAGESFKV 16191
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
D + G P P ++W +EL N+ + I SL++ +A D+G Y A N+ G
Sbjct: 16192 DADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG 16251
Query: 349 TDSTSAEIYI 358
S + + +
Sbjct: 16252 ERSVTVNVKV 16261
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/94 (30%), Positives = 44/94 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP E+L+N V L C+V G P P+ W + + I + + + GY
Sbjct: 24554 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 24613
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L+I DA Y + A N+ G VS TA L++
Sbjct: 24614 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24647
Score = 48.5 bits (114), Expect = 4e-05
Identities = 101/438 (23%), Positives = 156/438 (35%), Gaps = 100/438 (22%)
Query: 872 NDDNIRETKNAVIRDLGK--KITFSDVRPNQQEYKISSFEQRLMNEIEFRLE-RTPVDES 928
ND + T++ ++D GK ITF D+ I Q + + E + V E
Sbjct: 5592 NDQRLHTTRSVSMQDEGKTHSITFKDL-------SIDDTSQIRVEAMGMSSEAKLTVLEG 5644
Query: 929 DDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKR 988
D P F +L+ + E V C+I P V WFKDGK+I K
Sbjct: 5645 D---------------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEI-KP 5687
Query: 989 NEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ--GRISCSGHLMVQSLPIRSRLT 1046
+++ ++ +G L ++ D G YT + G++ + P+ S
Sbjct: 5688 SKNAVIKADGKKR-MLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEV 5746
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRL-------CRLD------ 1093
++ R + + E D + LQ P + EG++ CRLD
Sbjct: 5747 METETARFETEISEDDIH-ANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVD 5805
Query: 1094 ---------------CKVSGLPPP-----------------------ELTWLLNGQPVLP 1115
+V GL P + W L G+ + P
Sbjct: 5806 FQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEP 5865
Query: 1116 DASHKMLVRETG-VHSLLIDPLTQRDAGTYKCIATN-KTGQNSFSLELSVVAKEVKKAPV 1173
S K++ R G VH+L + + DAG + A + KT N F VK+ PV
Sbjct: 5866 --SDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----------VKEPPV 5913
Query: 1174 ILEK-LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL 1232
K L++ V EG LEC V V ++K E + + I L+
Sbjct: 5914 EFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRK---LV 5970
Query: 1233 IQPAKKSDAGWYTLSAKN 1250
I D YT AK+
Sbjct: 5971 IHDCTPEDIKTYTCDAKD 5988
Score = 48.5 bits (114), Expect = 4e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT KL+ E V L C + P V+W+ +GKE++ S + I G L +
Sbjct: 5646 PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRMLIL 5704
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+A + D G+Y+C GTD TS ++ IE
Sbjct: 5705 KKALKSDIGQYTCDC----GTDKTSGKLDIE 5731
Score = 48.5 bits (114), Expect = 4e-05
Identities = 54/231 (23%), Positives = 91/231 (39%), Gaps = 22/231 (9%)
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG- 360
W +G+ L +PD I + G +HSL + + TG A+N+ + + + G
Sbjct: 5767 WKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGL 5826
Query: 361 ------VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ 414
V+ + E E++ P E VP+++ V + ++
Sbjct: 5827 LRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVK 5886
Query: 415 QCQSPTNYLQGLDGKP-----IIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ L D K + PV FTK L++ + EG V EC V + KV+W
Sbjct: 5887 LEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEV-SRENAKVKW 5945
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASN 519
++ GT IL+ K + + LVI + ED +TC A +
Sbjct: 5946 FKNGT--------EILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 5988
Score = 48.5 bits (114), Expect = 4e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLEL--SVVAKEVKKAPVI---LEKLQNCGVPEG 1186
+I LTQ ++ A N G S E+ + + PVI LE + G
Sbjct: 20456 IISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAG 20515
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
V+L + G P P W KD++ + + ++TT A +LI+ A + ++G Y L
Sbjct: 20516 TSVKLRAGISGKPAPTIEWYKDDKELQTNA--LVCVENTTDLASILIKDADRLNSGCYEL 20573
Query: 1247 SAKNEAGIVSCTARLDI 1263
+N G S T R+ I
Sbjct: 20574 KLRNAMGSASATIRVQI 20590
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ G+ V V G P PK+EW + T+IE D LQ ++ E L I
Sbjct: 9036 IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD--ALQITKEEVSRSEAKTELSIP 9093
Query: 504 EVFAEDSGCFTCTASNKYGTV 524
+ ED G +T TASN+ G+V
Sbjct: 9094 KAVREDKGTYTVTASNRLGSV 9114
Score = 47.8 bits (112), Expect = 7e-05
Identities = 61/274 (22%), Positives = 105/274 (38%), Gaps = 66/274 (24%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVY----------------WFKDGKQISKRNEHCKMRREGD 999
+ EG+ V F ++ I VP+ Y W+ + ++ ++ R G
Sbjct: 2215 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGR 2274
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+L ++ T +D G Y+ + + +C L ++ PI
Sbjct: 2275 Q--NLTVKDVTKEDQGEYSFVIDGK--KTTCK--LKMKPRPIA----------------- 2311
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP-DAS 1118
LQ D EG + +L+ KVS L E W+ +GQ V P D
Sbjct: 2312 ---------------ILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRV 2355
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
H ++ +++ H LLI+ +T+ DAG Y +L LS + + ++ L
Sbjct: 2356 HIVIDKQS--HMLLIEDMTKEDAGNYSFTIP--------ALGLSTSGRVSVYSVDVITPL 2405
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
++ V EG LEC+V W ++E I
Sbjct: 2406 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI 2439
Score = 47.8 bits (112), Expect = 7e-05
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 34/286 (11%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
FT+ L + EV E ++L C V P +V WY +E+ + I+ G L I
Sbjct: 6093 FTKNLANIEVSETDTIKLVC-EVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQN 6151
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
A ED G Y+C + T ++ + +++ + P E+ +K V S
Sbjct: 6152 AHLEDAGNYNCRLPS----SRTDGKVKVHELAA-EFISKPQNLEILEGEKAEFVCSISKE 6206
Query: 391 SAVIP--------------PAVPQAQHLVAQPRVATIQQCQS---PTNYLQGLDGKPIIA 433
S + + + V + AT+Q + + +I
Sbjct: 6207 SFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE 6266
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
L++ E Q VVF C V K +W+R I DS + ILQK
Sbjct: 6267 KLRIVVPLKDTRVKEQQEVVFNCEVN-TEGAKAKWFRNEEAIFDSSKYIILQK------- 6318
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDL 538
+ + TL I + +D + + +N G V S A L V EDL
Sbjct: 6319 -DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE-EEDL 6362
Score = 47.4 bits (111), Expect = 9e-05
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 6/126 (4%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV--AKEVKKAPVILEKLQNCGVPEGH 1187
SL++ L + ++ A N G S E V AKE P IL Q + G
Sbjct: 12485 SLVVTGLKEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQLLPPKILMPEQ-ITIKAGK 12542
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLS 1247
+R+E V G P P WKK + + T +++H+ + + L+I+ + D+G+Y+L+
Sbjct: 12543 KLRIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSS-SILIIKDVTRKDSGYYSLT 12600
Query: 1248 AKNEAG 1253
A+N +G
Sbjct: 12601 AENSSG 12606
Score = 47.4 bits (111), Expect = 9e-05
Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 9/146 (6%)
Query: 900 QQEYKISSFEQRLMNEIEFR-LERTPVDESDDEIQHDEIPT-GKCIAPIFDKRLKH---F 954
Q+EY + E++ + +FR + RT V+ S D + + + P D +
Sbjct: 12876 QEEYTATGLEEKA--QYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLL 12933
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
V G+ V + G P+P V W KDG + K E KM + + C+L + S D
Sbjct: 12934 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLL-KPAEGIKMAMQRN-LCTLELFSVNRKDS 12991
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLP 1040
G+YTI A N G S + L V P
Sbjct: 12992 GDYTITAENSSGSKSATIKLKVLDKP 13017
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/137 (25%), Positives = 50/137 (36%), Gaps = 14/137 (10%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E L++ E R A + A D P + Y EP+ V E
Sbjct: 1762 EGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPV-------------RVLE 1808
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G + C V G P P+V WY G+ + S + G +H L I + DTG
Sbjct: 1809 GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IHYLDIVDCKSYDTGEVKVT 1867
Query: 343 ASNIYGTDSTSAEIYIE 359
A N G ++ I+
Sbjct: 1868 AENPEGVIEHKVKLEIQ 1884
Score = 46.6 bits (109), Expect = 2e-04
Identities = 39/134 (29%), Positives = 55/134 (41%), Gaps = 14/134 (10%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H LE +E + Q ++ SS + L P FT KL + E
Sbjct: 5256 HKLEMKEVTLDDISQIKAQV--------KELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 5307
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+ L C V P V+W+ +G+E+ SP I G L I +A +D G Y C
Sbjct: 5308 ITLKCEVSKDVP--VKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDC-- 5363
Query: 346 IYGTDSTSAEIYIE 359
GTD T A + +E
Sbjct: 5364 --GTDKTKANVTVE 5375
Score = 46.6 bits (109), Expect = 2e-04
Identities = 76/301 (25%), Positives = 114/301 (37%), Gaps = 58/301 (19%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLH 1005
F K L+ V EG+ C+ V KV WFK+G +I K K DG L
Sbjct: 5915 FTKPLEDQTVEEGATAVLECE-VSRENAKVKWFKNGTEILKSK---KYEIVADGRVRKLV 5970
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
I T +D YT A + + SC+ +++ P
Sbjct: 5971 IHDCTPEDIKTYTCDAKD--FKTSCNLNVV-----------------------------P 5999
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
F RP D+ E + R +C++S ++ W +G + + ++ +
Sbjct: 6000 PHVEFLRP-----LTDLQVREKEMARFECELS-RENAKVKWFKDGAEIKKGKKYD-IISK 6052
Query: 1126 TGVHSLLIDPLTQRDAGTYKC-IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V L+I+ D Y C + T +T S L+V+ +E V + L N V
Sbjct: 6053 GAVRILVINKCLLDDEAEYSCEVRTART-----SGMLTVLEEEA----VFTKNLANIEVS 6103
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG-YACLLIQPAKKSDAGW 1243
E ++L C V V ++K D E I R I T G L+IQ A DAG
Sbjct: 6104 ETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEIL----TEGRKRILVIQNAHLEDAGN 6159
Query: 1244 Y 1244
Y
Sbjct: 6160 Y 6160
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 8/97 (8%)
Query: 951 LKHF-RVTEGSPVTFTCKIVGIPVPKVYWFK------DGKQISKRNEHCKMRREGDGTCS 1003
LK F V EG+ V KI G+P P + WFK D K+ + H + D TC+
Sbjct: 9750 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN-KLVVDDTCT 9808
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L I + D G YTI A N G S L V P
Sbjct: 9809 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 9845
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ EG V ++KG P P + W++ D+ + +L + ++ CTLVI
Sbjct: 9754 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKE-PVLYDTHVNKLVVDDTCTLVIP 9812
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ D+G +T TA N GT S +L+V G
Sbjct: 9813 QSRRSDTGLYTITAVNNLGTASKEMRLNVLG 9843
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I LT + ++ A N+ G++ L + V+A++++ P + V +++
Sbjct: 18983 ISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKI 19042
Query: 1192 ECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ G P W+KD +T+ TR +S + T L I+ A K D G Y L N
Sbjct: 19043 DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS---LSIKEASKEDVGTYELCVSN 19099
Query: 1251 EAGIVS 1256
AG ++
Sbjct: 19100 SAGSIT 19105
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/97 (29%), Positives = 45/97 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP + LQ+ V EG E + G P P W +D + I + + G A
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
L I K+++G Y+L A N +G + TA L + A+
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE 100
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/98 (26%), Positives = 39/98 (39%), Gaps = 1/98 (1%)
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L P M +EG R C G P P +TWL GQ + A H++ + + I
Sbjct: 26192 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKY-KSTFEISS 26250
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV 1173
+ D G Y + N G+ L++ V + V
Sbjct: 26251 VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAV 26288
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/90 (28%), Positives = 42/90 (46%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P +K+ EV G + C + P + +W+ G+E+ S I + + SL I
Sbjct: 4462 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEI 4521
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
D G Y+C ASN YG+ S +A + +
Sbjct: 4522 LRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGR 338
V GT V+ I+ G+P P +W +G E++ + + + V+ N S LTI DTG
Sbjct: 11150 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIK-TDEHYTVETDNFSSVLTIKNCLRRDTGE 11208
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y SN G+ + + + +
Sbjct: 11209 YQITVSNAAGSKTVAVHLTV 11228
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P Q L ++V EG VQL+ + V + + W +G+E++ S +HIV H L
Sbjct: 2308 RPIAILQGLSDQKVCEGDIVQLE-VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2366
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I + +ED G YS F G STS + + V D N E + +VS
Sbjct: 2367 LIEDMTKEDAGNYS-FTIPALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSV 2424
Query: 387 PPTTS 391
P TS
Sbjct: 2425 PDVTS 2429
Score = 45.4 bits (106), Expect = 4e-04
Identities = 60/245 (24%), Positives = 86/245 (35%), Gaps = 15/245 (6%)
Query: 808 QPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKS 867
+P P P P ++ P P P +P AP + A+ T
Sbjct: 4602 KPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 4661
Query: 868 PQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYK--ISSFEQRLMNEIEFRLERTPV 925
P PV + + +GKK + + K I ++ + IE R
Sbjct: 4662 PPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAE-RRKLR 4720
Query: 926 DESDDEIQHDEIPTG---KCIAPIFDKRLKHFRVTE----GSPVTFTCKIVGIPVPKVYW 978
S E DE P K + F K +K +TE GS F C +V W
Sbjct: 4721 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFEC-LVSPSTAITTW 4779
Query: 979 FKDGKQISKRNEHCKMRREGDGTC-SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ 1037
KDG I + +H R DG LHI D G YT + + + L+V+
Sbjct: 4780 MKDGSNIRESPKH---RFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 4836
Query: 1038 SLPIR 1042
LP+R
Sbjct: 4837 ELPVR 4841
Score = 45.1 bits (105), Expect = 5e-04
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 3/122 (2%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I L Q + +++ A N+ G + L + V+AK++ P V G +++
Sbjct: 15736 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 15795
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ IG P P W KDN +P + + T + L I+ A + D G Y + N
Sbjct: 15796 DVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNS 15853
Query: 1252 AG 1253
AG
Sbjct: 15854 AG 15855
Score = 45.1 bits (105), Expect = 5e-04
Identities = 22/80 (27%), Positives = 43/80 (53%)
Query: 277 SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT 336
S V G ++++ + G P P + W +G L+ + I++ + +L +L+I E ++D
Sbjct: 16866 SYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDG 16925
Query: 337 GRYSCFASNIYGTDSTSAEI 356
G+Y +N+ G + S EI
Sbjct: 16926 GQYGITVANVVGQKTASIEI 16945
Score = 45.1 bits (105), Expect = 5e-04
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E +R E A AAG + P S + ++ + + PR + + R+ V G +L
Sbjct: 17215 EDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEV-ELPRISMDPKFRDTIVVNAGETFRL 17273
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ V G P P + W KE+E S I L + +A D G+Y ASN+ G
Sbjct: 17274 EADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 17333
Query: 349 TDSTSAEIYI 358
+ S + +
Sbjct: 17334 SKSFPVNVKV 17343
Score = 44.7 bits (104), Expect = 6e-04
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 2/110 (1%)
Query: 931 EIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE 990
EI + + P D V EG ++ +PVP V W KDGK++ K ++
Sbjct: 8001 EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV-KASD 8059
Query: 991 HCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
M+ + + L + + D G YTI N G + S ++ V LP
Sbjct: 8060 RLTMKND-HISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP 8108
Score = 44.7 bits (104), Expect = 6e-04
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K ++ V G+ V F I G+PVP W DG +I K +EH + + + L I++
Sbjct: 11143 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI-KTDEHYTVETDNFSSV-LTIKN 11200
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y I +N G + + HL V +P
Sbjct: 11201 CLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 11232
Score = 44.3 bits (103), Expect = 8e-04
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSLT 327
P F K S + EG + D VVG P P+ W+ +G+++ N +V + SL
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
I A D+G ++ A N G S S + +E V
Sbjct: 1471 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1504
Score = 44.3 bits (103), Expect = 8e-04
Identities = 34/136 (25%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 1144 YKCIATNKTG-----QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
++ A N+TG + + S++ + + E AP I +++++ G +L C+++G
Sbjct: 24131 FRVFAENETGLSRPRRTAMSIKTKLTSGE---APGIRKEMKDVTTKLGEAAQLSCQIVGR 24187
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W + + + +R + M D + L + ++ D G YT A NE G V +
Sbjct: 24188 PLPDIKWYRFGKELIQSR-KYKMSSDGRTHT-LTVMTEEQEDEGVYTCIATNEVGEVETS 24245
Query: 1259 ARLDIYA--QWHHQIP 1272
++L + A Q+H P
Sbjct: 24246 SKLLLQATPQFHPGYP 24261
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/201 (21%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
V W + KE++ S I G ++ LT+ ++D G+Y+ +A G + TS ++ +
Sbjct: 2517 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYA----GENMTSGKLTVA 2572
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSP-------------PTTSAVIPPAVPQAQHL-V 405
G + S D E EV++P P T+ + + + L +
Sbjct: 2573 GGAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 2632
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
A ++ I + K + A K L+NL+ +E Q VF +
Sbjct: 2633 AATKLDDIGEYTYKV-ATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKG 2691
Query: 466 VEWYREGTLIEDSPDFRILQK 486
V+W + G ++E + + I K
Sbjct: 2692 VQWIKNGVVLESNEKYAISVK 2712
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/288 (20%), Positives = 109/288 (37%), Gaps = 39/288 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F L +V E + +C V P RW +E+ +++ G HS+
Sbjct: 5467 PLIFITPLSDVKVFEKDEAKFEC-EVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMV 5525
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-----------VSSSDSEGDPNKEEMN 376
I A ED +Y A + + TS ++ IEG V++ + E E++
Sbjct: 5526 IKSAAFEDEAKYMFEAEDKH----TSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELS 5581
Query: 377 ----RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPII 432
R++ TT +V + + + +I G+ + +
Sbjct: 5582 HDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKD--LSIDDTSQIRVEAMGMSSEAKL 5639
Query: 433 AA----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
P FT LQ+ + E V+ +C + A +P V+W+++G I+ S + I
Sbjct: 5640 TVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGK 5698
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ M L++ + D G +TC GT + +L + E
Sbjct: 5699 KRM--------LILKKALKSDIGQYTCDC----GTDKTSGKLDIEDRE 5734
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 31/258 (12%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V G DC + P V WY +GK+LE S + G +H+LT+ + E
Sbjct: 5830 LKDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 5888
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIE--GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSA 392
D G A + T A ++++ V + D EE EVS
Sbjct: 5889 DAGEVQLTAKDF----KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 5944
Query: 393 VIPPAV----PQAQHLVAQPRV--ATIQQCQSPTNYLQGLDGKPI-------IAAP--VF 437
+ +VA RV I C D K + P F
Sbjct: 5945 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEF 6004
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
+ L +L E ++ FEC + + KV+W+++G I+ + I+ K +
Sbjct: 6005 LRPLTDLQVREKEMARFECEL-SRENAKVKWFKDGAEIKKGKKYDIISK--------GAV 6055
Query: 498 CTLVIAEVFAEDSGCFTC 515
LVI + +D ++C
Sbjct: 6056 RILVINKCLLDDEAEYSC 6073
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 5/121 (4%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +T+ ++ R GT V+L + G P P + WY + KEL+ + + + +L S+
Sbjct: 20503 PLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL 20559
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I +A ++G Y N G S SA I ++ + G P + + +K + P
Sbjct: 20560 IKDADRLNSGCYELKLRNAMG--SASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRP 20617
Query: 388 P 388
P
Sbjct: 20618 P 20618
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYK 1145
G RL VSG PPP +TW G D + + ++ T +SLLI D + + DAG Y
Sbjct: 23089 GASLRLMVSVSGRPPPVITWSKQG----IDLASRAIIDTTESYSLLIVDKVNRYDAGKYT 23144
Query: 1146 CIATNKTGQNSFSLELSV 1163
A N++G+ S ++ + V
Sbjct: 23145 IEAENQSGKKSATVLVKV 23162
Score = 43.1 bits (100), Expect = 0.002
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVILEKLQ---NCGVPEGH 1187
+ LT+ A ++ IA N G S E S + ++ +AP I ++ + G
Sbjct: 15046 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 15105
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G PPP W KD + + T + I + +T L+ + + + D+G YTL
Sbjct: 15106 AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN---LVNKDSTRRDSGAYTL 15162
Query: 1247 SAKNEAG 1253
+A N G
Sbjct: 15163 TATNPGG 15169
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 3/103 (2%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
A G +P S PS + P+ ++ ++ + G +L+ V G PPP + W
Sbjct: 15064 AAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEW 15123
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+GKELE + + I A +L ++ D+G Y+ A+N
Sbjct: 15124 SKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATN 15166
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/211 (22%), Positives = 78/211 (36%), Gaps = 18/211 (8%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V EGT+ L+C V V+WY ++++ + + G L I
Sbjct: 2405 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHAS 2464
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPT----- 389
D G Y I G T+ + +E + D E + E+S
Sbjct: 2465 DEGPYKL----IVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520
Query: 390 -TSAVIPPAVP---QAQHLVAQPRVAT-IQQCQSPTNYLQG---LDGKPIIAAPVFTKML 441
I P+ +A + + V ++ + + G GK +A +K L
Sbjct: 2521 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPL 2580
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
+ + +E Q VFEC V P K EW R+G
Sbjct: 2581 TDQTVAESQEAVFECEVAN-PDSKGEWLRDG 2610
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD- 1140
+V H G + R+ VSG PPP +TW +N + + +A+ + T + S ++ QR
Sbjct: 10162 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEAT----IETTAISSSMVIKNCQRSH 10217
Query: 1141 AGTYKCIATNKTGQNSFSLELSVV 1164
G Y +A N+ G+ ++ + V+
Sbjct: 10218 QGVYSLLAKNEAGERKKTIIVDVL 10241
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 8/125 (6%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCG----VPEGHPVRLECRVIGM 1198
++ A N G+ L SV+AK++ P + E C V G +R+ RV G
Sbjct: 11505 FRIKAANIVGEGEPRELAESVIAKDILHPPEV-ELDVTCRDVITVRVGQTIRILARVKGR 11563
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W K+ + + +R+ + QD L I+ A ++D G Y +SAKN +G +
Sbjct: 11564 PEPDITWTKEGKVL-VREKRVDLIQDLPRVE-LQIKEAVRADHGKYIISAKNSSGHAQGS 11621
Query: 1259 ARLDI 1263
A +++
Sbjct: 11622 AIVNV 11626
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/90 (21%), Positives = 44/90 (48%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P + + G ++++ V+G P P + W +G+ L+ + +++ + L I
Sbjct: 17940 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 17999
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
E ++D G+Y+ A+N GT + + + +
Sbjct: 18000 KEGNKDDFGKYTVTATNSAGTATENLSVIV 18029
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 248 GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVP--EGTRVQLDCIVVGIPPPQVRWYCE 305
G + P + SS+ +EP +P + ++ + G+ +D + G P P+V W E
Sbjct: 22253 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22312
Query: 306 GKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
L+ + + I + +LT+ ++ D+GRY N G + S + + G
Sbjct: 22313 EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 22367
Score = 42.0 bits (97), Expect = 0.004
Identities = 42/181 (23%), Positives = 75/181 (41%), Gaps = 11/181 (6%)
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
TW+ +G + H+ + +ID + DAG Y C+ + + + +L V
Sbjct: 4778 TWMKDGSNIRESPKHRFIADGKDRKLHIID-VQLSDAGEYTCVLRLGNKEKTSTAKLVVE 4836
Query: 1165 AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
V+ + E++ V +G P+ L C + V W+KD + + RI
Sbjct: 4837 ELPVRFVKTLEEEVT---VVKGQPLYLSCELNKERDVV--WRKDGKIVVEKPGRIV--PG 4889
Query: 1225 TTGYA-CLLIQPAKKSDAGWYTLSAKNEAGI--VSCTARLDIYAQWHHQIPPPMSVRPSG 1281
G L I A +DAG YT++ +N + SC +++ W + V+P G
Sbjct: 4890 VIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKG 4949
Query: 1282 S 1282
+
Sbjct: 4950 T 4950
Score = 42.0 bits (97), Expect = 0.004
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 16/165 (9%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E + E A AG + P S ++ ++ P P L + G +
Sbjct: 13968 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLT---IKAGDTI 14024
Query: 287 QLDCI-VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ I ++G P P+ W GK++ S I LTI A +D G Y+ A+N
Sbjct: 14025 VLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATN 14084
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI--QKPNEVSSPP 388
+GT ++ + D G P E++ + +K +PP
Sbjct: 14085 PFGTKVEHVKVTV-----LDVPGPPGPVEISNVSAEKATLTWTPP 14124
Score = 42.0 bits (97), Expect = 0.004
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 2/84 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + G + ++G P P + W KDG+ + K+ + T
Sbjct: 17938 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPL-KQTTRVNVEETATSTV 17996
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
LHI+ DD G YT+ A N G
Sbjct: 17997 -LHIKEGNKDDFGKYTVTATNSAG 18019
Score = 41.6 bits (96), Expect = 0.005
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V G V L+ V G P P WKKD + P +++M ++ L + + D+
Sbjct: 12935 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CTLELFSVNRKDS 12991
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
G YT++A+N +G S T +L + + PP SV+
Sbjct: 12992 GDYTITAENSSGSKSATIKLKVL----DKPGPPASVK 13024
Score = 41.6 bits (96), Expect = 0.005
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
LD V G P P ++W +G + P KM + + + +L + + ++D+G Y A N
Sbjct: 12943 LDATVFGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENS 13001
Query: 1152 TGQNSFSLELSVVAKEVKKAPVILEKL 1178
+G S +++L V+ K A V + K+
Sbjct: 13002 SGSKSATIKLKVLDKPGPPASVKINKM 13028
Score = 41.2 bits (95), Expect = 0.007
Identities = 74/335 (22%), Positives = 131/335 (39%), Gaps = 58/335 (17%)
Query: 922 RTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
R P +D +++ E+ A F + ++ + EG F C I P V W +D
Sbjct: 6163 RLPSSRTDGKVKVHEL------AAEFISKPQNLEILEGEKAEFVCSISKESFP-VQWKRD 6215
Query: 982 GKQISKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHL-MVQSL 1039
K + +++ + DG L ++ T D G Y +M G + HL +++ L
Sbjct: 6216 DKTLESGDKYDVI---ADGKKRVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKL 6268
Query: 1040 PIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGL 1099
I L +RV+E+ QE F +C+V+
Sbjct: 6269 RIVVPLKD--------TRVKEQ-----QEVVF---------------------NCEVN-T 6293
Query: 1100 PPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL 1159
+ W N + + D+S +++++ V++L I D Y TN G+N S
Sbjct: 6294 EGAKAKWFRNEEAIF-DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 6352
Query: 1160 ELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+V +E + I+E L++ E V C+V + W K+ E +P R+
Sbjct: 6353 ANLIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGEEVPFD-NRV 6407
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
S D + L I+ D G Y ++A + +
Sbjct: 6408 SYRVDKYKH-MLTIKDCGFPDEGEYIVTAGQDKSV 6441
Score = 41.2 bits (95), Expect = 0.007
Identities = 29/102 (28%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
+VVAK+ P I + + V EG + + +P P W KD + + + +R++M
Sbjct: 8005 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKAS-DRLTM 8063
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
D A L + + ++DAG YT++ +N+ G S TA +++
Sbjct: 8064 KNDHIS-AHLEVPKSVRADAGIYTITLENKLG--SATASINV 8102
Score = 40.8 bits (94), Expect = 0.009
Identities = 22/79 (27%), Positives = 36/79 (45%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V GT+++L V G P P++ W L+ I I ++TI ++ DTG Y
Sbjct: 7330 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 7389
Query: 340 SCFASNIYGTDSTSAEIYI 358
A N+ G + E+ +
Sbjct: 7390 IIEAVNVCGRATAVVEVNV 7408
Score = 40.8 bits (94), Expect = 0.009
Identities = 31/136 (22%), Positives = 59/136 (43%), Gaps = 5/136 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
++ L + ++ A N G + S + + P ++ + V EG V +
Sbjct: 9706 VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIV 9765
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQP-AKKSDAGWYTLS 1247
++ G+P P W K P +E + +++ C L+ P +++SD G YT++
Sbjct: 9766 AKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT 9825
Query: 1248 AKNEAGIVSCTARLDI 1263
A N G S RL++
Sbjct: 9826 AVNNLGTASKEMRLNV 9841
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +R+ V G PPP W + T+P + + + T + ++I+ ++S G
Sbjct: 10164 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLP----QEATIETTAISSSMVIKNCQRSHQG 10219
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
Y+L AKNEAG T +D+
Sbjct: 10220 VYSLLAKNEAGERKKTIIVDV 10240
Score = 40.8 bits (94), Expect = 0.009
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 9/126 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E +R E A AAG + P S ++ + + P P++ + V G
Sbjct: 18297 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVI---VVHAGETF 18353
Query: 287 QLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ + G P P V W +GKEL E + + I +L + + D G+Y SN
Sbjct: 18354 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 18413
Query: 346 IYGTDS 351
+ GT S
Sbjct: 18414 VGGTKS 18419
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGN 322
+P + P T +++RE ++++D G P V W +G+ L+ + +++ +
Sbjct: 19022 KPSVELPFHTFNVKARE-----QLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT 19076
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ SL+I EA +ED G Y SN G+ + I +
Sbjct: 19077 VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIV 19112
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGHPVR 1190
L+ D ++ IA N G S + S ++ ++ P++ E + G +R
Sbjct: 21546 LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLR 21605
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMH-QDTTGYACLLIQPAKKSDAGWYTLSAK 1249
++ V G P P W KD I +R++M D G L ++ A + G YT+ AK
Sbjct: 21606 IKALVQGRPVPRVTWFKDGVEI---EKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAK 21662
Query: 1250 NEAGIVSCTARLDI 1263
N +G ++ +
Sbjct: 21663 NASGSAKAEIKVKV 21676
Score = 40.8 bits (94), Expect = 0.009
Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
+ G +++ +V G P P+V W+ +G E+E ++ I SL + +A + G Y
Sbjct: 21598 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 21657
Query: 340 SCFASNIYGTDSTSAEIYIE 359
+ A N G S AEI ++
Sbjct: 21658 TVEAKNASG--SAKAEIKVK 21675
Score = 40.4 bits (93), Expect = 0.011
Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 26/236 (11%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV--RWYCEGKELENSPDIHIVQAGNL 323
G F ++L+ EVPE +L+CIV P + +WY EL+++ I
Sbjct: 2218 GAVVEFVKELQDIEVPESYSGELECIV---SPENIEGKWYHNDVELKSNGKYTITSRRGR 2274
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAE----IYIEGVSSSD-SEGDPNKEEMN-- 376
+LT+ + +ED G YS T + ++G+S EGD + E+
Sbjct: 2275 QNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVS 2334
Query: 377 -------RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--D 427
++ EV VI Q+ L+ + S T GL
Sbjct: 2335 LESVEGVWMKDGQEVQPSDRVHIVID---KQSHMLLIEDMTKEDAGNYSFTIPALGLSTS 2391
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
G+ + + L++++ EG V EC+V V+WY I+ PD R+
Sbjct: 2392 GRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIK--PDDRV 2445
Score = 40.4 bits (93), Expect = 0.011
Identities = 24/97 (24%), Positives = 40/97 (41%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + EG +T C G P P+V W G++I + + D
Sbjct: 26955 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 27014
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
+L I D G YT+ N G S + ++ ++S+
Sbjct: 27015 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 27051
Score = 40.0 bits (92), Expect = 0.015
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 10/93 (10%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLL-------NGQPVLPDAS-HKMLVRETGVHSLLI 1133
M EG + K+ G+P P LTW N +PVL D +K++V +T +L+I
Sbjct: 9754 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVI 9811
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
+ D G Y A N G S + L+V+ +
Sbjct: 9812 PQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 9844
Score = 40.0 bits (92), Expect = 0.015
Identities = 34/140 (24%), Positives = 61/140 (43%), Gaps = 8/140 (5%)
Query: 231 QEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+E K+ + AA A G + P + +E L PP+ + G +++++
Sbjct: 12492 KEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQL-LPPKILMP-EQITIKAGKKLRIEA 12548
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
V G P P +W E+ S + + +A + L I + +D+G YS A N GTD
Sbjct: 12549 HVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD 12608
Query: 351 STSAEIYIEGVSSSDSEGDP 370
+ ++ + D+ G P
Sbjct: 12609 TQKIKVVV-----MDAPGPP 12623
Score = 40.0 bits (92), Expect = 0.015
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
++ G RL+ VSG PPP + W +G+ + A ++ + + +L+ T+RD+
Sbjct: 15099 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDS 15157
Query: 1142 GTYKCIATNKTG 1153
G Y ATN G
Sbjct: 15158 GAYTLTATNPGG 15169
Score = 40.0 bits (92), Expect = 0.015
Identities = 23/81 (28%), Positives = 36/81 (44%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F + V G +++D +G P P V W+ + L+ + ++ N LT
Sbjct: 15775 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 15834
Query: 328 IAEAFEEDTGRYSCFASNIYG 348
I +A ED G Y +N G
Sbjct: 15835 IKDACREDVGHYVVKLTNSAG 15855
Score = 39.7 bits (91), Expect = 0.019
Identities = 40/179 (22%), Positives = 72/179 (40%), Gaps = 11/179 (6%)
Query: 184 KLESQNKVMQENSSSFSDLSERRERSSVPIP---IPADTRDNEVNHALEQQEAKRREAEQ 240
++ES+ + E S F+ S + + P+ A D + + +L+ E K + +
Sbjct: 4285 EVESKYLISTEEVSYFNVQSRVKYLDATPVTKGVASAVVSDEKQDESLKPSEEKEESSSE 4344
Query: 241 AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV 300
+ +E + + + P+ P L EG V L + +V
Sbjct: 4345 SGTEEVATVKIQEAEGGLIKEDGPMIHTP-----LVDTVSEEGDIVHLTTSITNAK--EV 4397
Query: 301 RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEED-TGRYSCFASNIYGTDSTSAEIYI 358
WY E K + + +Q N ++L I + ED G Y C A N G +TSA++ +
Sbjct: 4398 NWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTV 4456
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 10/121 (8%)
Query: 1139 RDAGTYK--CIATNKTGQNSFS-LELSVVAKEVKKAPVIL---EKLQNCGVPEGHPVRLE 1192
RD TYK +A N G++ + + V+ K+ + P ++ + + G +RL
Sbjct: 10808 RDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLS 10867
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ G+P P WKK++ P T+ RI + T + L I+ A D G Y+L+ +N A
Sbjct: 10868 AIIKGVPFPKVTWKKEDRDAP-TKARIDV---TPVGSKLEIRNAAHEDGGIYSLTVENPA 10923
Query: 1253 G 1253
G
Sbjct: 10924 G 10924
Score = 39.7 bits (91), Expect = 0.019
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
+E+ P L P + G+ R++ V G P P W G+ + +SH + +
Sbjct: 12522 KEQLLPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKAD 12579
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
L+I +T++D+G Y A N +G ++ +++ V+
Sbjct: 12580 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVM 12617
Score = 39.7 bits (91), Expect = 0.019
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
VP G PV L + G PPP W + ER+++ + T A L I+ D G
Sbjct: 23378 VPAGRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTG 23435
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
YTL KN G S T ++ I
Sbjct: 23436 EYTLELKNVTGTTSETIKVII 23456
Score = 39.7 bits (91), Expect = 0.019
Identities = 68/316 (21%), Positives = 110/316 (34%), Gaps = 54/316 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG-DGTC 1002
AP R++ RV G F + P +V W+ +G ++ E K+ G
Sbjct: 26001 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ---ESSKIHYTNTSGVL 26057
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I +DD G Y + N +G S L V + + Q RD
Sbjct: 26058 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYAS------------QRRD 26105
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
+E + F P + V+ + ++ S
Sbjct: 26106 EEVPRSVF--PELTRTEAYAVSSFKKTSEMEASSS------------------------- 26138
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ-NSFSLELSVVAKEVKK--APVILEKLQ 1179
VRE V S + + + + A K+ SLE +++K A IL K +
Sbjct: 26139 VRE--VKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR 26196
Query: 1180 NCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG--YACLLIQPAK 1237
+ V EG R C G P P W + + + + + HQ TT + I +
Sbjct: 26197 SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS----ARHQVTTTKYKSTFEISSVQ 26252
Query: 1238 KSDAGWYTLSAKNEAG 1253
SD G Y++ +N G
Sbjct: 26253 ASDEGNYSVVVENSEG 26268
Score = 39.3 bits (90), Expect = 0.025
Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 11/127 (8%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSR---EVPEGTRVQLDCI 291
R A AA E G+T P + EP +PP + + ++ G +++ +
Sbjct: 8703 RVSAVNAAGEGPPGETQP------VTVAEPQ-EPPAVELDVSVKGGIQIMAGKTLRIPAV 8755
Query: 292 VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDS 351
V G P P W E EL+ + I G L I +A +D GRY A+N G+
Sbjct: 8756 VTGRPVPTKVWTKEEGELDKDRVV-IDNVGTKSELIIKDALRKDHGRYVITATNSCGSKF 8814
Query: 352 TSAEIYI 358
+A + +
Sbjct: 8815 AAARVEV 8821
Score = 38.9 bits (89), Expect = 0.033
Identities = 62/298 (20%), Positives = 114/298 (38%), Gaps = 61/298 (20%)
Query: 951 LKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
LK V EG+ CK+ V V W+ + +QI K ++ + +G L I T
Sbjct: 2405 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI-KPDDRVQAIVKGTKQ-RLVINRTH 2462
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
+ D+G Y ++ GR+ + +L V+ + I
Sbjct: 2463 ASDEGPYKLIV----GRVETNCNLSVEKIKI----------------------------- 2489
Query: 1071 FRPHFLQAPGDMVAHEGR--LCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ D+ E + + ++ SG+ ++ W + + P + +K + +
Sbjct: 2490 -----IRGLRDLTCTETQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYK-IEAHGKI 2540
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
+ L + + + D G Y T G+N S +L+V + K L + V E
Sbjct: 2541 YKLTVLNMMKDDEGKY----TFYAGENMTSGKLTVAGGAISK------PLTDQTVAESQE 2590
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY-ACLLIQPAKKSDAGWYT 1245
EC V P W +D + +P T ++ ++ G+ L+I K D G YT
Sbjct: 2591 AVFECEVAN-PDSKGEWLRDGKHLPLTN---NIRSESDGHKRRLIIAATKLDDIGEYT 2644
Score = 38.9 bits (89), Expect = 0.033
Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 40/222 (18%)
Query: 814 PIPVSPTSRIQNPVAFLSSVLPSLPAIPP---------TNAMGLPRSAPSMPSQGLAKKN 864
P SP R ++PV LPS P+ P T A P P G +
Sbjct: 19696 PSETSPLIRAEDPV-----FLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEY 19750
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTP 924
KS DD +T +R G + T S + + F + +N++ P
Sbjct: 19751 KKS-----DDTDWKTSIQSLR--GTEYTISGLTTGAEYV----FRVKSVNKVG---ASDP 19796
Query: 925 VDESDDEIQHDEIPTGKCIAPIFD---KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
D SD +I + P+FD + K V G+ T T G PVP V W K
Sbjct: 19797 SDSSDPQIAKEREEE-----PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKP 19851
Query: 982 GKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAAN 1023
+ R D SL IE+ +D G YT+ N
Sbjct: 19852 DTDLRTR----AYVDTTDSRTSLTIENANRNDSGKYTLTIQN 19889
Score = 38.9 bits (89), Expect = 0.033
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 5/80 (6%)
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS-LLIDPLTQRDAGTY 1144
+G + RL + G P P W GQ D S + ++ + H+ L+I + D+GTY
Sbjct: 23778 QGGVIRLTIPIKGKPFPICKWTKEGQ----DISKRAMIATSETHTELVIKEADRGDSGTY 23833
Query: 1145 KCIATNKTGQNSFSLELSVV 1164
+ NK G+ + +++ V+
Sbjct: 23834 DLVLENKCGKKAVYIKVRVI 23853
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 8/114 (7%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT +Q +D + + K+L L+ G + V G P PK+ W +
Sbjct: 7303 PTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTK-------- 7354
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
D + Q K ++ + T+ I + D+G + A N G +++ +++V
Sbjct: 7355 ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7408
Score = 38.5 bits (88), Expect = 0.043
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +RL G P P W K + + R +H T ++ L ++ ++DAG
Sbjct: 21997 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL---RADIHT-TDSFSTLTVENCNRNDAG 22052
Query: 1243 WYTLSAKNEAGIVSCT 1258
YTL+ +N +G S T
Sbjct: 22053 KYTLTVENNSGSKSIT 22068
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 5/96 (5%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G+ + LD V G P P++ W KEL+ + + G + I D+G+Y+
Sbjct: 22690 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLT 22749
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
N GT + S + + DS G K ++R+
Sbjct: 22750 VKNASGTKAVSVMVKV-----LDSPGPCGKLTVSRV 22780
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/154 (21%), Positives = 71/154 (46%), Gaps = 16/154 (10%)
Query: 1144 YKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKL--QNCGVPE-GHPVRLECRVIGMP 1199
++ A N+ G++ S + A ++++ P + + Q+C V + G +R+ + G P
Sbjct: 9407 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 9466
Query: 1200 PPVFYWKKDNETIPCTRERI------SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
P W+ D + ++ + + + + ++I K+S G Y+++AKN+AG
Sbjct: 9467 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 9526
Query: 1254 IVSCTARLDIYAQWHHQIP-PPMSVRPSGSRYGS 1286
+ R+ + +P PP ++ S GS
Sbjct: 9527 QKTANCRVKVM-----DVPGPPKDLKVSDITRGS 9555
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 9/122 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWY-C 304
A G + P ++ + P PP K EV EGT V + + G+P P + W+
Sbjct: 9724 AAGVSKPSATVGPCDCQRP-DMPPSIDLK-EFMEVEEGTNVNIVAKIKGVPFPTLTWFKA 9781
Query: 305 EGKELENSP----DIHI--VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
K+ +N D H+ + + +L I ++ DTG Y+ A N GT S + +
Sbjct: 9782 PPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9841
Query: 359 EG 360
G
Sbjct: 9842 LG 9843
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/142 (23%), Positives = 65/142 (45%), Gaps = 10/142 (7%)
Query: 1121 MLVRETGVH--SLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVI--- 1174
M TG++ ++ ++ L ++ ++ A NK G + + ++ +E +AP I
Sbjct: 16514 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 16573
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
LE + + G +RL + G P P W K + I ++ T+ + L++
Sbjct: 16574 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI----RDAAIIDVTSSFTSLVLD 16629
Query: 1235 PAKKSDAGWYTLSAKNEAGIVS 1256
+ D+G YTL+ +N +G S
Sbjct: 16630 NVNRYDSGKYTLTLENSSGTKS 16651
Score = 38.1 bits (87), Expect = 0.056
Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 24/126 (19%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRD 1140
+V + G RL+ V G P P + WL + + + S + ++ T +LLI + D
Sbjct: 17263 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEI--EESARCEIKNTDFKALLIVKDAIRID 17320
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL------ECR 1194
G Y A+N G SF PV ++ L G PEG PV++ +C
Sbjct: 17321 GGQYILRASNVAGSKSF--------------PVNVKVLDRPGPPEG-PVQVTGVTSEKCS 17365
Query: 1195 VIGMPP 1200
+ PP
Sbjct: 17366 LTWSPP 17371
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
GR L ++G PPP +W G L ++ + T V L I T RD G Y
Sbjct: 23381 GRPVELVIPIAGRPPPAASWFFAGSK-LRESERVTVETHTKVAKLTIRETTIRDTGEYTL 23439
Query: 1147 IATNKTGQNSFSLELSVVAK 1166
N TG S ++++ ++ K
Sbjct: 23440 ELKNVTGTTSETIKVIILDK 23459
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 448 EGQLVVFECRVKGAP-SPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG V + C+++ S +V WY +E+S + I + + + L + ++
Sbjct: 25209 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYE--------DGVAILYVKDIT 25260
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHVRG 534
D G + C N YG SS A+L V+G
Sbjct: 25261 KLDDGTYRCKVVNDYGEDSSYAELFVKG 25288
Score = 37.7 bits (86), Expect = 0.073
Identities = 60/224 (26%), Positives = 88/224 (39%), Gaps = 25/224 (11%)
Query: 157 FIEELSSLFK-SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPI 215
F E L+ L K S SS I+ AC+ K N +++ S +DL + S PI
Sbjct: 11406 FAENLAGLSKPSPSSDPIK--ACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPI 11463
Query: 216 ---------PADTRDNEVNH-ALEQQEAKRREAEQAASE------AAG--GDTTPGSSPS 257
P + N +N L +Q A R +E AA G+ P
Sbjct: 11464 LGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAE 11523
Query: 258 SLYYEEPLGQPPRFTQKLRSREVPE---GTRVQLDCIVVGIPPPQVRWYCEGKELENSPD 314
S+ ++ L PP + R+V G +++ V G P P + W EGK L
Sbjct: 11524 SVIAKDIL-HPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKR 11582
Query: 315 IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ ++Q L I EA D G+Y A N G SA + +
Sbjct: 11583 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 11626
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 8/84 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
GQ + RVKG P P + W +EG ++ ++Q PR L I E
Sbjct: 11551 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPR--------VELQIKEAVRA 11602
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
D G + +A N G A ++V
Sbjct: 11603 DHGKYIISAKNSSGHAQGSAIVNV 11626
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ +++ +SG P P +TW +G P L + + + +L I + D G Y
Sbjct: 16872 GQDLKIEVPISGRPKPTITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16930
Query: 1147 IATNKTGQNSFSLELSVVAK-EVKKAPV 1173
N GQ + S+E+ + K + K PV
Sbjct: 16931 TVANVVGQKTASIEIVTLDKPDPPKGPV 16958
Score = 37.4 bits (85), Expect = 0.096
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 17/164 (10%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W+ ++P+ ++K+ E G L Y+ A NK G + S L +
Sbjct: 6966 WIRCNMKLVPELTYKVTGLEKGNKYL------------YRVSAENKAGVSDPSEILGPLT 7013
Query: 1166 KE---VKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+ V+ + V +P+ + G P P W ++ + T +R+ M
Sbjct: 7014 ADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLE-TGDRVKM- 7071
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ + YA L+I P+++SD G YTL +N +S +++ A+
Sbjct: 7072 KTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR 7115
Score = 37.4 bits (85), Expect = 0.096
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDAGWY 1244
G +RL V G PPP W K N + R+RI + +T + L + K DAG Y
Sbjct: 13336 GVTMRLYVPVKGRPPPKITWSKPNVNL---RDRIGLDIKSTDFDTFLRCENVNKYDAGKY 13392
Query: 1245 TLSAKNEAG 1253
L+ +N G
Sbjct: 13393 ILTLENSCG 13401
Score = 37.4 bits (85), Expect = 0.096
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVI-LEKLQNCGV--PEGHPVRLECRVIGMP 1199
++ A N GQ + V AK++ +AP I L+ V G V++ G P
Sbjct: 20868 FRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRP 20927
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
PP W+KD + + + R S+ ++T + L I ++D G Y L+ +N G
Sbjct: 20928 PPTVTWRKDEKNLG-SDARYSI-ENTDSSSLLTIPQVTRNDTGKYILTIENGVG 20979
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 21/140 (15%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEP-----LGQPPRFTQKLRSREVPEGTRVQLD 289
R +A A E+ DTT G P++ EEP +G K G+++++
Sbjct: 9408 RVKAVNEAGESEPSDTT-GEIPATDIQEEPEVFIDIGAQDCLVCKA-------GSQIRIP 9459
Query: 290 CIVVGIPPPQVRWYCEGKE-------LENSP-DIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
++ G P P+ W +GK + + P D + A N + I E TG+YS
Sbjct: 9460 AVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSI 9519
Query: 342 FASNIYGTDSTSAEIYIEGV 361
A N G + + + + V
Sbjct: 9520 TAKNKAGQKTANCRVKVMDV 9539
Score = 37.0 bits (84), Expect = 0.13
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + V G + I G P P + W KDG + K+ + D T
Sbjct: 16856 IEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL-KQTTRINVTDSLDLT- 16913
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+L I+ T DD G Y I AN G+ + S ++ P
Sbjct: 16914 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 16951
Score = 37.0 bits (84), Expect = 0.13
Identities = 45/176 (25%), Positives = 76/176 (43%), Gaps = 12/176 (6%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP-LTQRD 1140
++A G ++ G PPP +TW + + + DA + + T SLL P +T+ D
Sbjct: 20909 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYS--IENTDSSSLLTIPQVTRND 20966
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL--ECRVIGM 1198
G Y N G+ + S V+ +V P +KLQ V G L + G
Sbjct: 20967 TGKYILTIENGVGEP----KSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGG 21022
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
P + Y + + T +S +T + LI ++K+ ++ + A+NE GI
Sbjct: 21023 SPIINYVIEKRDATKRTWSVVSHKCSSTSFK--LIDLSEKTPF-FFRVLAENEIGI 21075
Score = 36.6 bits (83), Expect = 0.16
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 3/85 (3%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G P+ + G P PKV W K G R + D L I ++T DD G
Sbjct: 12246 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLV---DTMAFLVIPNSTRDDSG 12302
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y++ NP G + ++ V P
Sbjct: 12303 KYSLTLVNPAGEKAVFVNVRVLDTP 12327
Score = 36.6 bits (83), Expect = 0.16
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G +++ V G P P ++W+ +G+P+ + ++ V ET ++L I + D G Y
Sbjct: 17954 GEDLKIEIPVIGRPRPNISWVKDGEPL--KQTTRVNVEETATSTVLHIKEGNKDDFGKYT 18011
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
ATN G + +L + V+ K
Sbjct: 18012 VTATNSAGTATENLSVIVLEK 18032
Score = 36.6 bits (83), Expect = 0.16
Identities = 33/131 (25%), Positives = 60/131 (45%), Gaps = 16/131 (12%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG----QNSFSLELSVVAKEVKKAPV-----ILEKLQNCGV 1183
++ L ++ ++ A N G + +FS SV+ KE + P I +L C
Sbjct: 22233 VERLVEKTEYEFRVKAKNDAGYSEPREAFS---SVIIKEPQIEPTADLTGITNQLITCKA 22289
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G P ++ + G P P WK + + T +R+S+ T L ++ + + D+G
Sbjct: 22290 --GSPFTIDVPISGRPAPKVTWKLEEMRLKET-DRVSI-TTTKDRTTLTVKDSMRGDSGR 22345
Query: 1244 YTLSAKNEAGI 1254
Y L+ +N AG+
Sbjct: 22346 YFLTLENTAGV 22356
Score = 36.6 bits (83), Expect = 0.16
Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKK-DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G + L+ V G P P W K D E C E++S+ Q T A +I+ +SD+G Y
Sbjct: 22690 GSDLVLDAAVGGKPEPKIIWTKGDKELDLC--EKVSL-QYTGKRATAVIKFCDRSDSGKY 22746
Query: 1245 TLSAKNEAG 1253
TL+ KN +G
Sbjct: 22747 TLTVKNASG 22755
Score = 36.2 bits (82), Expect = 0.21
Identities = 51/221 (23%), Positives = 85/221 (38%), Gaps = 40/221 (18%)
Query: 853 PSMPSQGLAKKN--TKSPQPVNDDNIRETKNAVI-------RDLGKKITFSDV---RPNQ 900
PS PS+ + K+ K PVN + I T N+V D G KI V +
Sbjct: 10725 PSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 10784
Query: 901 QEYKISSFEQRLMNEIEFRL--------------------ERTPVDESDDEIQHDEIPTG 940
+E++ ++ E ++++ E P + + D +
Sbjct: 10785 EEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPP 10844
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
+ I R +H +V G + + I G+P PKV W K+ R+ K R +
Sbjct: 10845 ELILDANMAREQHIKV--GDTLRLSAIIKGVPFPKVTWKKE-----DRDAPTKARIDVTP 10897
Query: 1001 TCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S L I + +D G Y++ NP G + S ++V P
Sbjct: 10898 VGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 10938
Score = 35.8 bits (81), Expect = 0.28
Identities = 20/83 (24%), Positives = 35/83 (42%), Gaps = 1/83 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V G R + G+P P W +G + D H + + L I +RD
Sbjct: 11148 LVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDT 11206
Query: 1142 GTYKCIATNKTGQNSFSLELSVV 1164
G Y+ +N G + ++ L+V+
Sbjct: 11207 GEYQITVSNAAGSKTVAVHLTVL 11229
Score = 35.8 bits (81), Expect = 0.28
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Query: 968 IVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
I+G P+PK W K GK I R + L I+ T D G YTI A NP G
Sbjct: 14031 ILGKPLPKSSWSKAGKDI--RPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 14087
Score = 35.8 bits (81), Expect = 0.28
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGH 1187
+ LT+ ++ IA N G S + + + AK+ + P I + V G
Sbjct: 17210 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 17269
Query: 1188 PVRLECRVIGMPPPVFYW-KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G P P W + D E R I ++T A L+++ A + D G Y L
Sbjct: 17270 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEI---KNTDFKALLIVKDAIRIDGGQYIL 17326
Query: 1247 SAKNEAG 1253
A N AG
Sbjct: 17327 RASNVAG 17333
Score = 35.4 bits (80), Expect = 0.36
Identities = 41/162 (25%), Positives = 70/162 (43%), Gaps = 19/162 (11%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV- 1164
W+ G+PV A KM V TG L + Y+ A N+ G + S +
Sbjct: 7262 WVACGEPV---AETKMEV--TG--------LEEGKWYAYRVKALNRQGASKPSRPTEEIQ 7308
Query: 1165 AKEVKKAPVI---LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
A + ++AP I ++ L V G + L V G P P W K + + + RI++
Sbjct: 7309 AVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDK-RITI 7367
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
++ + + I +K+SD G Y + A N G + +++
Sbjct: 7368 -ENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7408
Score = 35.4 bits (80), Expect = 0.36
Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G I G P+P + W K +++S N + D SL ++ D G
Sbjct: 16183 VHAGESFKVDADIYGKPIPTIQWIKGDQELS--NTARLEIKSTDFATSLSVKDAVRVDSG 16240
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
NY + A N G S + ++ V P
Sbjct: 16241 NYILKAKNVAGERSVTVNVKVLDRP 16265
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/94 (21%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
K ++ P + S GQ + E + G P P + W ++G ++ + +
Sbjct: 16852 KDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINV----- 16906
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ ++ TL I E +D G + T +N G
Sbjct: 16907 ---TDSLDLTTLSIKETHKDDGGQYGITVANVVG 16937
Score = 35.4 bits (80), Expect = 0.36
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 6/111 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRD 1140
+V G + +++ ++G P P ++W +G + A +++ T H+LL + +RD
Sbjct: 19427 IVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII--STDNHTLLTVKDCIRRD 19484
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKA-PVILEKL--QNCGVPEGHP 1188
G Y N G S ++ V+ K A P+ + L + C + G P
Sbjct: 19485 TGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRP 19535
Score = 35.4 bits (80), Expect = 0.36
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 4/72 (5%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +G + T I G P P W K+G+ ISKR M + L I+ D G
Sbjct: 23776 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKR----AMIATSETHTELVIKEADRGDSG 23831
Query: 1016 NYTIMAANPQGR 1027
Y ++ N G+
Sbjct: 23832 TYDLVLENKCGK 23843
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE-DTGRYSC 341
G+ ++L + +G P P + W+ K L+NS +I I + L + + G+Y
Sbjct: 24271 GSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKV 24330
Query: 342 FASNIYGTDSTSAEIYIE 359
SN++GT ++ I+
Sbjct: 24331 QLSNVFGTVDAILDVEIQ 24348
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 11/99 (11%)
Query: 437 FTKMLQNLSASEGQ-LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
FT+ LQ++ A E + FEC P KV+WY++G + + +R+ S +
Sbjct: 2130 FTQELQDVVAKEKDTMATFECETS-EPFVKVKWYKDGMEVHEGDKYRM-----HSDRKVH 2183
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ L I AED C N V + A+L V G
Sbjct: 2184 FLSILTIDTSDAEDYSCVLVEDEN----VKTTAKLIVEG 2218
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVH-SLLIDPLTQRDA 1141
+A E RL + G P P ++W P+ D ++ V + V+ +L++ + DA
Sbjct: 13621 LAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT--RVSVESSAVNTTLIVYDCQKSDA 13678
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAK 1166
G Y N G ++ + VV K
Sbjct: 13679 GKYTITLKNVAGTKEGTISIKVVGK 13703
Score = 35.0 bits (79), Expect = 0.48
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP---VILEKLQNCGVP 1184
+ ++ L ++ ++ A N G ++ V E + AP + E + V
Sbjct: 14358 ITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVR 14417
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G +R+ + G P P W KDN + + R ++ ++T + L+I + D G +
Sbjct: 14418 AGLSIRIFVPIKGRPAPEVTWTKDNINL---KNRANI-ENTESFTLLIIPECNRYDTGKF 14473
Query: 1245 TLSAKNEAG 1253
++ +N AG
Sbjct: 14474 VMTIENPAG 14482
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/129 (22%), Positives = 47/129 (36%), Gaps = 8/129 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I P++ + D V K + G+ E V G P
Sbjct: 15059 VIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPP 15118
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW ++G +E + I + LV + DSG +T TA+N G
Sbjct: 15119 PTMEWSKDGKELEGTAKLEI--------KIADFSTNLVNKDSTRRDSGAYTLTATNPGGF 15170
Query: 524 VSSIAQLHV 532
I + V
Sbjct: 15171 AKHIFNVKV 15179
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G ++D + G P P + W + G L + + + SL + + D+
Sbjct: 16181 IVVHAGESFKVDADIYGKPIPTIQW-IKGDQELSNTARLEIKSTDFATSLSVKDAVRVDS 16239
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKE-VKKAPVIL 1175
G Y A N G+ S ++ + V+ + + PV++
Sbjct: 16240 GNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI 16274
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +++ + G P PV W KD I R R + T + L ++ + D G
Sbjct: 19429 VKAGEVLKINADIAGRPLPVISWAKDGIEIE-ERARTEI-ISTDNHTLLTVKDCIRRDTG 19486
Query: 1243 WYTLSAKNEAG 1253
Y L+ KN AG
Sbjct: 19487 QYVLTLKNVAG 19497
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 18/106 (16%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIV------------------VGIPPPQVRWYCEGK 307
G+P + ++++++ E + LD + G PPP V W + K
Sbjct: 20879 GEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEK 20938
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
L + I + LTI + DTG+Y N G +S
Sbjct: 20939 NLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSS 20984
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/99 (24%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR- 1139
D++ EG + +P P ++W +G+ V AS ++ ++ + + L P + R
Sbjct: 8023 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV--KASDRLTMKNDHISAHLEVPKSVRA 8080
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVV-----AKEVKKAPV 1173
DAG Y NK G + S+ + V+ K++K + +
Sbjct: 8081 DAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDI 8119
Score = 34.7 bits (78), Expect = 0.62
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 14/144 (9%)
Query: 890 KITFSDVRPNQQEYKIS------SFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCI 943
K FS++ N E+ +S ++E R++ + P + SD D++ K
Sbjct: 15033 KANFSNILEN--EFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIK 15090
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR-REGDGTC 1002
+ K + G + G P P + W KDGK++ K+ + D +
Sbjct: 15091 VDVKFKDTVILKA--GEAFRLEADVSGRPPPTMEWSKDGKELEGT---AKLEIKIADFST 15145
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
+L + +T D G YT+ A NP G
Sbjct: 15146 NLVNKDSTRRDSGAYTLTATNPGG 15169
Score = 34.7 bits (78), Expect = 0.62
Identities = 23/82 (28%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDA 1241
V G +++ + G P P W K ++ + T + +T +A L ++ A + D+
Sbjct: 16183 VHAGESFKVDADIYGKPIPTIQWIKGDQELSNTAR---LEIKSTDFATSLSVKDAVRVDS 16239
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G Y L AKN AG S T + +
Sbjct: 16240 GNYILKAKNVAGERSVTVNVKV 16261
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 2/78 (2%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
K V G PV I G P P WF G ++ + +E + L I TT
Sbjct: 23374 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKL-RESERVTVETH-TKVAKLTIRETTI 23431
Query: 1012 DDDGNYTIMAANPQGRIS 1029
D G YT+ N G S
Sbjct: 23432 RDTGEYTLELKNVTGTTS 23449
Score = 34.3 bits (77), Expect = 0.81
Identities = 67/299 (22%), Positives = 109/299 (36%), Gaps = 33/299 (11%)
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-GTRVQLDCIVVGIP 296
AE +AS G + S + Q FTQ+L+ E T +C P
Sbjct: 2097 AEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFEC-ETSEP 2155
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
+V+WY +G E+ + +H L+I D YSC T+A++
Sbjct: 2156 FVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENV-KTTAKL 2214
Query: 357 YIEGV------SSSDSE-GDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPR 409
+EG D E + E+ I P + + V ++ + R
Sbjct: 2215 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDV--ELKSNGKYTITSRR 2272
Query: 410 VATIQQCQSPTNYLQG-----LDGK----PIIAAPVFTKMLQNLS---ASEGQLVVFECR 457
+ T QG +DGK + P +LQ LS EG +V E +
Sbjct: 2273 GRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVK 2332
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
V S + W ++G ++ S I+ K M L+I ++ ED+G ++ T
Sbjct: 2333 V-SLESVEGVWMKDGQEVQPSDRVHIVIDKQSHM--------LLIEDMTKEDAGNYSFT 2382
Score = 34.3 bits (77), Expect = 0.81
Identities = 28/137 (20%), Positives = 53/137 (38%), Gaps = 9/137 (6%)
Query: 398 VPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECR 457
VP ++ V + R P+ + + K P ++ EG+ +
Sbjct: 7979 VPDKEY-VLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVP 8037
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+ P P V W+++G ++ S R+ K A L + + D+G +T T
Sbjct: 8038 FRAVPVPTVSWHKDGKEVKASD--RLTMKNDHISAH------LEVPKSVRADAGIYTITL 8089
Query: 518 SNKYGTVSSIAQLHVRG 534
NK G+ ++ + V G
Sbjct: 8090 ENKLGSATASINVKVIG 8106
Score = 34.3 bits (77), Expect = 0.81
Identities = 19/82 (23%), Positives = 38/82 (46%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V EG ++ + +P P V W+ +GKE++ S + + L + ++ D G Y
Sbjct: 8026 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 8085
Query: 340 SCFASNIYGTDSTSAEIYIEGV 361
+ N G+ + S + + G+
Sbjct: 8086 TITLENKLGSATASINVKVIGL 8107
Score = 34.3 bits (77), Expect = 0.81
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 10/92 (10%)
Query: 268 PPRFTQKLRSR----EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI------HI 317
PP +L R +V G V + V G+P P++ W +E D +
Sbjct: 9022 PPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEV 9081
Query: 318 VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
++ L+I +A ED G Y+ ASN G+
Sbjct: 9082 SRSEAKTELSIPKAVREDKGTYTVTASNRLGS 9113
Score = 34.3 bits (77), Expect = 0.81
Identities = 36/153 (23%), Positives = 57/153 (37%), Gaps = 6/153 (3%)
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN--SFSLEL 1161
+ ++L + + + HK+ + L + D Y+ A N GQ SF +
Sbjct: 10377 INYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKP 10436
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
E+ + L+ + G L R G P P W KD + E
Sbjct: 10437 ITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV---LEDDRT 10493
Query: 1222 HQDTTGYACLLIQ-PAKKSDAGWYTLSAKNEAG 1253
H TT L + AK+SD+G Y + +N G
Sbjct: 10494 HIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 10526
Score = 34.3 bits (77), Expect = 0.81
Identities = 21/106 (19%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 428 GKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
G P+I P+ +T++++ + G V + G P+P +EWY++ D +
Sbjct: 20496 GGPVIDLPLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKD--------DKELQTN 20544
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ ++ +++I + +SGC+ N G+ S+ ++ +
Sbjct: 20545 ALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQI 20590
Score = 34.3 bits (77), Expect = 0.81
Identities = 22/65 (33%), Positives = 25/65 (38%), Gaps = 2/65 (3%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
GH V LE G P P W KD +P T L I+ AKK G YT
Sbjct: 21206 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 21263
Query: 1246 LSAKN 1250
+ N
Sbjct: 21264 VILDN 21268
Score = 34.3 bits (77), Expect = 0.81
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
AGG P P ++ E L + P + R +E V +G ++L + G P P +W
Sbjct: 23740 AGGPGEPAEVPGTVKVTEML-EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKW 23798
Query: 303 YCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
EG+++ ++ H+ L I EA D+G Y N G + ++ + G
Sbjct: 23799 TKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 23855
Query: 362 SSS 364
+S
Sbjct: 23856 PNS 23858
Score = 34.3 bits (77), Expect = 0.81
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V +G +RL + G P P+ W K+ + I + +M + + L+I+ A + D+G
Sbjct: 23776 VRQGGVIRLTIPIKGKPFPICKWTKEGQDI----SKRAMIATSETHTELVIKEADRGDSG 23831
Query: 1243 WYTLSAKNEAG 1253
Y L +N+ G
Sbjct: 23832 TYDLVLENKCG 23842
Score = 34.3 bits (77), Expect = 0.81
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 5/111 (4%)
Query: 1057 RVQERDKEPL-QERFFRPHFLQAPGDMVAHE---GRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ ER E L Q+ F H + M +H G+ R V P E+ W NG
Sbjct: 25982 KTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVE 26041
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
L ++S +GV +L I D+GTY+ + TN G+ S L V
Sbjct: 26042 -LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDV 26091
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/74 (24%), Positives = 31/74 (41%), Gaps = 1/74 (1%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F + L + V E C + V+WY G+E++ + G++H L
Sbjct: 6450 PTEFVEHLEDQTVTEFDDAVFSC-QLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLI 6508
Query: 328 IAEAFEEDTGRYSC 341
I + +D Y+C
Sbjct: 6509 IKDCRLDDECEYAC 6522
Score = 33.9 bits (76), Expect = 1.1
Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
++D G P + W +GQ L + + + V SL I ++ D GTY+ +N
Sbjct: 19041 KIDVPFKGRPQATVNWRKDGQ-TLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSN 19099
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEKL 1178
G + + + V+ + P+ ++++
Sbjct: 19100 SAGSITVPITIIVLDRPGPPGPIRIDEV 19127
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/63 (28%), Positives = 29/63 (46%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V L+ G P P + W +G L+ S + + N +L+I A +E G+Y+
Sbjct: 21206 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 21265
Query: 343 ASN 345
N
Sbjct: 21266 LDN 21268
Score = 33.5 bits (75), Expect = 1.4
Identities = 22/94 (23%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
K+++ L G V F ++G P P +W +G+ I+ + + S+
Sbjct: 11143 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV------- 11195
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L I D+G + T SN G+ + L V
Sbjct: 11196 -LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 11228
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 13/103 (12%)
Query: 428 GKPIIAA-----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
G P+IA P S G+ + E V G P P + W ++G ++
Sbjct: 17928 GVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK------ 17981
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
Q ++ E L I E +D G +T TA+N GT +
Sbjct: 17982 --QTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 18022
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 924 PVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGK 983
P D S DEI A + K V G I G P+P V W KDGK
Sbjct: 18317 PSDSSGAITARDEIDAPN--ASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGK 18374
Query: 984 QISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
++ + +++ T +L ++ D G Y + +N G
Sbjct: 18375 ELEETAARMEIKSTIQKT-TLVVKDCIRTDGGQYILKLSNVGG 18416
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 14/105 (13%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G L+ + G P P++ W +G+ + A+ + +L++ + D
Sbjct: 18345 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18404
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
G Y +N G K P+ ++ L G PEG
Sbjct: 18405 GQYILKLSNVGG--------------TKSIPITVKVLDRPGPPEG 18435
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G LE + G P P W KD + + T R+ + + T L+++ ++D G
Sbjct: 18347 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGG 18405
Query: 1243 WYTLSAKNEAGIVS 1256
Y L N G S
Sbjct: 18406 QYILKLSNVGGTKS 18419
Score = 33.5 bits (75), Expect = 1.4
Identities = 36/169 (21%), Positives = 67/169 (39%), Gaps = 17/169 (10%)
Query: 873 DDNIRETKNAVIRDLGKKITFSDVRPNQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDE 931
D R NA IR+ + T D++ Q+ +++++ + M+E + +
Sbjct: 23014 DQWYRVHTNATIRNT--EFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEI------EP 23065
Query: 932 IQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEH 991
++ EIP + D K + G+ + + G P P + W K G ++ R
Sbjct: 23066 VERIEIPD----LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR--- 23118
Query: 992 CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ + L ++ D G YTI A N G+ S + + V P
Sbjct: 23119 -AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 23166
Score = 33.1 bits (74), Expect = 1.8
Identities = 27/107 (25%), Positives = 38/107 (35%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
DK L P + +G +V G P PE W NG +
Sbjct: 2021 DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYW 2080
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV 1168
E V L+I +T D+ + A N G+ S L V AK++
Sbjct: 2081 YWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQL 2127
Score = 33.1 bits (74), Expect = 1.8
Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 4/113 (3%)
Query: 917 EFRLERTPVDESDDEIQHDEIPTGKCIA-PIFDKRLKH-FRVTEGSPVTFTCKIVGIPVP 974
EFR++ D ++ +E+ + + P+ D +L V G + + G P P
Sbjct: 11800 EFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFP 11859
Query: 975 KVYWFKDGKQIS-KRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
+V W KD R+ K+ D + + D G Y + A N G
Sbjct: 11860 EVAWTKDKDATDLTRSPRVKIDTRADSS-KFSLTKAKRSDGGKYVVTATNTAG 11911
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 440 MLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT 499
M + ++ G+ + E V G P P +W + + S + + S+
Sbjct: 12532 MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI-------- 12583
Query: 500 LVIAEVFAEDSGCFTCTASNKYGT 523
L+I +V +DSG ++ TA N GT
Sbjct: 12584 LIIKDVTRKDSGYYSLTAENSSGT 12607
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/87 (26%), Positives = 32/87 (36%), Gaps = 8/87 (9%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDG---KQISKRNEHCKMRREGD 999
I P F F V G + +G P P V W KD KQ ++ N +
Sbjct: 15774 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN-----AESTE 15828
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQG 1026
L I+ +D G+Y + N G
Sbjct: 15829 NNSLLTIKDACREDVGHYVVKLTNSAG 15855
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/75 (28%), Positives = 33/75 (44%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V+W + I D+ + +LV+ V DSG +T T
Sbjct: 16594 IKGRPTPEVKWGKVDGEIRDAAIIDV----------TSSFTSLVLDNVNRYDSGKYTLTL 16643
Query: 518 SNKYGTVSSIAQLHV 532
N GT S+ + V
Sbjct: 16644 ENSSGTKSAFVTVRV 16658
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/99 (23%), Positives = 39/99 (39%), Gaps = 5/99 (5%)
Query: 945 PIFDKRLKHFRVTE---GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
P+ D L++ V + G+ V I G P P + W+KD K++ C
Sbjct: 20498 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV--ENTTDL 20555
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S+ I+ + G Y + N G S + + + P
Sbjct: 20556 ASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 20594
Score = 33.1 bits (74), Expect = 1.8
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 15/184 (8%)
Query: 1147 IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWK 1206
+ T KT + + + LS + AP I ++++ VP G R V P W
Sbjct: 25978 LKTQKTSERKYEV-LSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWY 26036
Query: 1207 KDNETIPCTRERISMHQ-DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI-- 1263
+ + +E +H +T+G L I D+G Y N G S A LD+
Sbjct: 26037 HNGVEL---QESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTG 26093
Query: 1264 -----YAQWHHQIPPPMSVRPSGSR---YGSLTSKGLDIFSAFSSMESTMVYSCSSRSVV 1315
YA P SV P +R Y + K A SS+ +R +
Sbjct: 26094 GDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESL 26153
Query: 1316 ESDE 1319
S E
Sbjct: 26154 SSYE 26157
Score = 32.7 bits (73), Expect = 2.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ R+ +V G P P++TW G+ VL L+++ L I + D G Y
Sbjct: 11551 GQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 11609
Query: 1147 IATNKTGQNSFSLELSVV 1164
A N +G S ++V+
Sbjct: 11610 SAKNSSGHAQGSAIVNVL 11627
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVI-----LEKLQNCGVPEG 1186
+ L + ++ A N+ G L+ ++ KE+ + P I + KL V G
Sbjct: 12192 VTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVI--VRAG 12249
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
P+RL V G P P W+K + ++ + DT + L+I + + D+G Y+L
Sbjct: 12250 CPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDL-VDTMAF--LVIPNSTRDDSGKYSL 12306
Query: 1247 SAKNEAG 1253
+ N AG
Sbjct: 12307 TLVNPAG 12313
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 9/81 (11%)
Query: 444 LSASEGQLVVFEC-RVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L+ G +V + G P PK W + G I S +I SM L I
Sbjct: 14016 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSM--------LTI 14067
Query: 503 AEVFAEDSGCFTCTASNKYGT 523
+D+G +T TA+N +GT
Sbjct: 14068 KYATRKDAGEYTITATNPFGT 14088
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 14/127 (11%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++++ V+G P P V W + L+ + ++ L I E D+G Y
Sbjct: 14708 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 14767
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP----AV 398
A NI G I + D G P K +EVSS T + PP V
Sbjct: 14768 ARNIVGEVGDVITIQVH-----DIPGPPTGP-----IKFDEVSSDFVTFSWDPPENDGGV 14817
Query: 399 PQAQHLV 405
P + ++V
Sbjct: 14818 PISNYVV 14824
Score = 32.7 bits (73), Expect = 2.4
Identities = 26/122 (21%), Positives = 46/122 (37%), Gaps = 8/122 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I + T + D + + K + + G+ E V G P
Sbjct: 17223 VIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPL 17282
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW R IE+S I +++ L++ + D G + ASN G+
Sbjct: 17283 PTIEWLRGDKEIEESARCEIKNTDFKAL--------LIVKDAIRIDGGQYILRASNVAGS 17334
Query: 524 VS 525
S
Sbjct: 17335 KS 17336
Score = 32.7 bits (73), Expect = 2.4
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 10/131 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVI---LEKLQNCGVPEGHP 1188
I LT ++ + NK G + S +AKE ++ P+ E + V G
Sbjct: 19772 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 19831
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTT-GYACLLIQPAKKSDAGWYTLS 1247
+ G P P W K P T R + DTT L I+ A ++D+G YTL+
Sbjct: 19832 FTMTVPFRGRPVPNVLWSK-----PDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLT 19886
Query: 1248 AKNEAGIVSCT 1258
+N S T
Sbjct: 19887 IQNVLSAASLT 19897
Score = 32.7 bits (73), Expect = 2.4
Identities = 28/151 (18%), Positives = 56/151 (37%), Gaps = 8/151 (5%)
Query: 383 EVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
+VS T + P ++A+ V TI + + D +
Sbjct: 21535 DVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFD 21594
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L G+ + + V+G P P+V W+++G IE + I + +L +
Sbjct: 21595 GLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST--------SLFV 21646
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ + G +T A N G+ + ++ V+
Sbjct: 21647 RDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 21677
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/94 (25%), Positives = 38/94 (40%), Gaps = 10/94 (10%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ + +G ++ +KG P P +W +EG I K +A E LV
Sbjct: 23772 EGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI----------SKRAMIATSETHTELV 23821
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGN 535
I E DSG + NK G + ++ V G+
Sbjct: 23822 IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 23855
Score = 32.3 bits (72), Expect = 3.1
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 5/81 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G RL + G+P P++TW + DA K + T V S L I D G Y
Sbjct: 10861 GDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAHEDGGIYS 10916
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
N G + S+++ V+ K
Sbjct: 10917 LTVENPAGSKTVSVKVLVLDK 10937
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCE--GKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V G ++L+ V G P P+V W + +L SP + I + ++ +A D G
Sbjct: 11841 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 11900
Query: 338 RYSCFASNIYGT 349
+Y A+N G+
Sbjct: 11901 KYVVTATNTAGS 11912
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 7/77 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+ V E ++G P P V W ++G +E++ + + TLV+ +
Sbjct: 18350 GETFVLEADIRGKPIPDVVWSKDGKELEET-------AARMEIKSTIQKTTLVVKDCIRT 18402
Query: 509 DSGCFTCTASNKYGTVS 525
D G + SN GT S
Sbjct: 18403 DGGQYILKLSNVGGTKS 18419
Score = 32.3 bits (72), Expect = 3.1
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 9/120 (7%)
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA-HEGRLCRLDCKVSGLPPPELT 1105
S G G ++ P E R H GD+V G LD V G P P++
Sbjct: 22654 SKGSESTGPVTCRDEYAPPKAELDARLH-----GDLVTIRAGSDLVLDAAVGGKPEPKII 22708
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR-DAGTYKCIATNKTGQNSFSLELSVV 1164
W + + D K+ ++ TG + + R D+G Y N +G + S+ + V+
Sbjct: 22709 WTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVL 22766
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
++ L + V E +C V P + W +GK L + +I G+ L IA
Sbjct: 2577 SKPLTDQTVAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAAT 2635
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
+D G Y+ + T TSA++ +E V
Sbjct: 2636 KLDDIGEYTYKVA----TSKTSAKLKVEAV 2661
Score = 32.0 bits (71), Expect = 4.0
Identities = 27/131 (20%), Positives = 52/131 (39%), Gaps = 10/131 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCI 291
EA+RR+ + GG+ P +P + + P +F ++++ + E V I
Sbjct: 4713 EAERRKLRPGS----GGEKPPDEAPFTYQLK---AVPLKFVKEIKDIILTESEFVGSSAI 4765
Query: 292 VVGIPPPQVR---WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ P W +G + SP + G L I + D G Y+C
Sbjct: 4766 FECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNK 4825
Query: 349 TDSTSAEIYIE 359
+++A++ +E
Sbjct: 4826 EKTSTAKLVVE 4836
Score = 32.0 bits (71), Expect = 4.0
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
RL + G P PE+ W + +L D + + + L+ID +T+ D+G Y N
Sbjct: 18754 RLFVTIKGRPEPEVKWE-KAEGILTDRAQIEVT--SSFTMLVIDNVTRFDSGRYNLTLEN 18810
Query: 1151 KTGQ----------NSFSLELSVVAKEVKKAPVIL 1175
+G +S S +++ +EVKK V L
Sbjct: 18811 NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTL 18845
Score = 32.0 bits (71), Expect = 4.0
Identities = 42/197 (21%), Positives = 71/197 (36%), Gaps = 33/197 (16%)
Query: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
KIVG + K +Q ++R C + C + + D + I+A N G
Sbjct: 21513 KIVGYSIEK-------RQGNERWVRCNFTDVSE--CQYTVTGLSPGDRYEFRIIARNAVG 21563
Query: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
IS P +S G ++ + P+ E F P + ++
Sbjct: 21564 TISP---------PSQSS---------GIIMTRDENVPPIVE--FGPEYFDG---LIIKS 21600
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G R+ V G P P +TW +G + + + G SL + T+ G Y
Sbjct: 21601 GESLRIKALVQGRPVPRVTWFKDGVEI-EKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 21659
Query: 1147 IATNKTGQNSFSLELSV 1163
A N +G +++ V
Sbjct: 21660 EAKNASGSAKAEIKVKV 21676
Score = 32.0 bits (71), Expect = 4.0
Identities = 18/75 (24%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
+D +SG P P++TW L + L + + +L + + D+G Y N
Sbjct: 22295 IDVPISGRPAPKVTWKLE-EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22353
Query: 1152 TGQNSFSLELSVVAK 1166
G +FS+ + V+ +
Sbjct: 22354 AGVKTFSVTVVVIGR 22368
Score = 31.6 bits (70), Expect = 5.3
Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 8/90 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE-EICTLVI 502
L+ G + E V+G P P+V W ++ +D+ D L + PR + + +
Sbjct: 11839 LTVKAGDTIRLEAGVRGKPFPEVAWTKD----KDATD---LTRSPRVKIDTRADSSKFSL 11891
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ D G + TA+N G+ + A ++V
Sbjct: 11892 TKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V W ++ I K ++ E L+I E D+G F T
Sbjct: 14428 IKGRPAPEVTWTKDN----------INLKNRANIENTESFTLLIIPECNRYDTGKFVMTI 14477
Query: 518 SNKYGTVSSIAQLHV 532
N G S + V
Sbjct: 14478 ENPAGKKSGFVNVRV 14492
Score = 31.6 bits (70), Expect = 5.3
Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 10/101 (9%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P P+V+W + ++ D + LVI V DSG + T
Sbjct: 18759 IKGRPEPEVKWEKAEGILTDRAQIEV----------TSSFTMLVIDNVTRFDSGRYNLTL 18808
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEP 558
N G+ ++ + V + N ++ + + EP
Sbjct: 18809 ENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 18849
Score = 31.6 bits (70), Expect = 5.3
Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 13/97 (13%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
KP + P T N+ A E QL + + KG P V W ++G ++++ + K
Sbjct: 19022 KPSVELPFHTF---NVKARE-QLKI-DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSK- 19075
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ +L I E ED G + SN G+++
Sbjct: 19076 -------TVTSLSIKEASKEDVGTYELCVSNSAGSIT 19105
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 8/81 (9%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
Q ++ G + + G P+PKV W E ++++ I K R+ TL
Sbjct: 22283 QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRT--------TLT 22334
Query: 502 IAEVFAEDSGCFTCTASNKYG 522
+ + DSG + T N G
Sbjct: 22335 VKDSMRGDSGRYFLTLENTAG 22355
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP T I G P PKV W + ++ K + + D T +L ++ + D G Y
Sbjct: 22290 GSPFTIDVPISGRPAPKVTWKLEEMRL-KETDRVSITTTKDRT-TLTVKDSMRGDSGRYF 22347
Query: 1019 IMAANPQG 1026
+ N G
Sbjct: 22348 LTLENTAG 22355
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++L V G PPP + W +G +L + I ++ +L L + + D G+Y+
Sbjct: 23089 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--LIVDKVNRYDAGKYTIE 23146
Query: 343 ASNIYGTDSTSAEIYI 358
A N G S + + +
Sbjct: 23147 AENQSGKKSATVLVKV 23162
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/90 (24%), Positives = 39/90 (43%), Gaps = 7/90 (7%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQP--VLPDASHKM---LVRETGVHS--LLID 1134
+V G R+ + G P P+ +W +G+ + D H + ET +S ++I
Sbjct: 9448 LVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIP 9507
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
+ G Y A NK GQ + + + V+
Sbjct: 9508 ECKRSHTGKYSITAKNKAGQKTANCRVKVM 9537
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G + ++ G P P + W K+GK + R + + ++ L I+ D G
Sbjct: 11548 VRVGQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLP-RVELQIKEAVRADHG 11605
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y I A N G S + V P
Sbjct: 11606 KYIISAKNSSGHAQGSAIVNVLDRP 11630
Score = 31.2 bits (69), Expect = 6.9
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 1162 SVVAKEVKKAP-VILEKLQNCG--VPEGHPVRLEC-RVIGMPPPVFYWKKDNETIPCTRE 1217
+++ K+ +AP ++L+ G + G + L ++G P P W K + I
Sbjct: 13994 TIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI--RPS 14051
Query: 1218 RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
I+ T + L I+ A + DAG YT++A N G
Sbjct: 14052 DITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 14087
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 6/90 (6%)
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+RL + G P P W+K E I R +I + T+ + L+I + D+G Y L+
Sbjct: 18753 LRLFVTIKGRPEPEVKWEKA-EGILTDRAQIEV---TSSFTMLVIDNVTRFDSGRYNLTL 18808
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
+N +G S TA +++ P +++R
Sbjct: 18809 ENNSG--SKTAFVNVRVLDSPSAPVNLTIR 18836
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/84 (26%), Positives = 33/84 (39%), Gaps = 6/84 (7%)
Query: 1076 LQAPGDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS---- 1130
L GD + G + V+GLP P++ W N + + +E S
Sbjct: 9029 LSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT 9088
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTG 1153
L I + D GTY A+N+ G
Sbjct: 9089 ELSIPKAVREDKGTYTVTASNRLG 9112
Score = 30.8 bits (68), Expect = 9.0
Identities = 20/69 (28%), Positives = 27/69 (39%), Gaps = 4/69 (5%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDDDGNY 1017
G T + G P PKV WFKD + + + H K T +L D G Y
Sbjct: 10461 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTT---PATLALEKIKAKRSDSGKY 10517
Query: 1018 TIMAANPQG 1026
++ N G
Sbjct: 10518 CVVVENSTG 10526
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/79 (21%), Positives = 32/79 (40%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
E + +L + G P P V W L + + + +L + + + D G+Y+
Sbjct: 13624 ENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTI 13683
Query: 342 FASNIYGTDSTSAEIYIEG 360
N+ GT + I + G
Sbjct: 13684 TLKNVAGTKEGTISIKVVG 13702
Score = 30.8 bits (68), Expect = 9.0
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYKCIATNKTGQ 1154
+ G P P+ +W G+ + P S + T S+L I T++DAG Y ATN G
Sbjct: 14031 ILGKPLPKSSWSKAGKDIRP--SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGT 14088
Query: 1155 NSFSLELSVVAKEVKKAPV 1173
++++V+ PV
Sbjct: 14089 KVEHVKVTVLDVPGPPGPV 14107
Score = 30.8 bits (68), Expect = 9.0
Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 12/76 (15%)
Query: 458 VKGAPSPKVEWYRE-GTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
+KG P+P+V+W R+ G ++ + S+ L++ V DSG + T
Sbjct: 15512 IKGRPAPEVKWARDHGESLDKA-----------SIESTSSYTLLIVGNVNRFDSGKYILT 15560
Query: 517 ASNKYGTVSSIAQLHV 532
N G+ S+ + V
Sbjct: 15561 VENSSGSKSAFVNVRV 15576
Score = 30.8 bits (68), Expect = 9.0
Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 8/88 (9%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE---GDGTCSLHIESTTSD 1012
V G + I G P+P + W KDG +I +R R E D L ++
Sbjct: 19429 VKAGEVLKINADIAGRPLPVISWAKDGIEIEER-----ARTEIISTDNHTLLTVKDCIRR 19483
Query: 1013 DDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y + N G S + + V P
Sbjct: 19484 DTGQYVLTLKNVAGTRSVAVNCKVLDKP 19511
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/77 (22%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+++ + G P P + W ++G IE+ I+ ++ L + +
Sbjct: 19432 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTL--------LTVKDCIRR 19483
Query: 509 DSGCFTCTASNKYGTVS 525
D+G + T N GT S
Sbjct: 19484 DTGQYVLTLKNVAGTRS 19500
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAGNLHSLTIAEAFEEDTGR 338
V G+ +++D + G P P+V +G L+ + + + A NL ++ + E+ D GR
Sbjct: 20116 VRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL-TINLKESVTADAGR 20174
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y A+N GT I +
Sbjct: 20175 YEITAANSSGTTKAFINIVV 20194
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 970 GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRIS 1029
G P P + W KDG + K +E + + + +L I++ + G YT++ N RI+
Sbjct: 21217 GKPKPSISWLKDGLPL-KESEFVRFSKT-ENKITLSIKNAKKEHGGKYTVILDNAVCRIA 21274
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 223 bits (568), Expect = 9e-58
Identities = 144/450 (32%), Positives = 227/450 (50%), Gaps = 47/450 (10%)
Query: 878 ETKNAVIRD-LGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHD- 935
E + A+IR + K QE+ ISSFE+RL+ EIE+R+ +T ++E +E +
Sbjct: 1173 EKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEK 1232
Query: 936 ---EIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
+I + + FD R+K++R+ EG VTF CK+ G P+PK+ W+KDGK+I K E
Sbjct: 1233 MAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRI-KHGERY 1291
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL------------- 1039
+M DG SL I +D+G YT A+N +G CSG L V+
Sbjct: 1292 QMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLE 1351
Query: 1040 ----------------PIR--------SRLTSAGQSHRGRS---RVQERDKEPLQERFFR 1072
PIR +R++ A S S R++E D+ L ER ++
Sbjct: 1352 PVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL-ERLYK 1410
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F+ P EG+ R D KV G P PE W +GQ ++ D +HK++++E G SL+
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I P T D+G + +A N+ G++S S+ L+V A E + P+ +EKL+N + EG + ++
Sbjct: 1471 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1530
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
R G P P W K+++ I + + T G A L I D+ WYT +A N+A
Sbjct: 1531 VRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKA 1590
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS 1282
G + ++++ ++ P + P G+
Sbjct: 1591 GRDTTRCKVNVEVEFAEPEPERKLIIPRGT 1620
Score = 111 bits (277), Expect = 5e-24
Identities = 91/322 (28%), Positives = 141/322 (43%), Gaps = 17/322 (5%)
Query: 950 RLKHFRVTEGSPVTFTCKIVGIPVP-KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
++ H EG V + CKI +V W+ +Q+ + +E ++ E DG L+++
Sbjct: 25076 QIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQL-ENSEKYEITYE-DGVAILYVKD 25133
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER-DKEPLQ 1067
T DDG Y N G S L V+ + R R +++ R D L
Sbjct: 25134 ITKLDDGTYRCKVVNDYGEDSSYAELFVKGV----REVYDYYCRRTMKKIKRRTDTMRLL 25189
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET- 1126
ER P F + A+ G R ++ P P +TW +GQ + P + K E+
Sbjct: 25190 ER--PPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 25247
Query: 1127 -GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNC 1181
G++ L I+ +T D Y +A NK G++S +L+V + P+ L N
Sbjct: 25248 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 25307
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
EG V E RV G+PPP W+KD + + +H+ YA L I+ D
Sbjct: 25308 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYA-LHIRDTLPEDT 25366
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G+Y ++A N AG SC A L +
Sbjct: 25367 GYYRVTATNTAGSTSCQAHLQV 25388
Score = 105 bits (262), Expect = 3e-22
Identities = 78/264 (29%), Positives = 111/264 (42%), Gaps = 35/264 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L++ V EG V L+C + G P P V WY E ++E+S D I + L
Sbjct: 896 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLM 955
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I EAF ED+GR++C A N GT STS + ++ + E
Sbjct: 956 IREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE-------------------- 995
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKP-IIAAPVFTKMLQNLSA 446
T+AV + + V V + G P I PV K++
Sbjct: 996 --TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV----- 1048
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG VVF C+V G P P V W + G + +++ K C LVI+ F
Sbjct: 1049 -EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGE------CKLVISMTF 1101
Query: 507 AEDSGCFTCTASNKYGTVSSIAQL 530
A+D+G +T NK+G S+ A L
Sbjct: 1102 ADDAGEYTIVVRNKHGETSASASL 1125
Score = 101 bits (251), Expect = 5e-21
Identities = 92/358 (25%), Positives = 151/358 (42%), Gaps = 58/358 (16%)
Query: 957 TEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGN 1016
+EG P F C++ G + KV W+ K+I K + +M + D T L I +D+G
Sbjct: 3311 SEGQPARFQCRVSGTDL-KVSWYSKDKKI-KPSRFFRMTQFED-TYQLEIAEAYPEDEGT 3367
Query: 1017 YTIMAANPQGRISCSGHLMVQS-----------------LPIRSRLTSAGQS--HRGR-- 1055
YT +A+N G++S + +L +++ S SA + H
Sbjct: 3368 YTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKEFSSSFLSAEEEGLHSAELQ 3427
Query: 1056 -SRVQER----DKEPLQERFFR-------PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPE 1103
S++ E + P+ F P F++ + G + L V G+P P+
Sbjct: 3428 LSKINETLELLSESPVYPTKFDSEKEGTGPIFIKEVSNADISMGDVATLSVTVIGIPKPK 3487
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL-- 1161
+ W NG + P A +K V + HSL+I D G Y C+A+N G+ S L
Sbjct: 3488 IQWFFNGVLLTPSADYKF-VFDGDDHSLIILFTKLEDEGEYTCMASNDYGKTICSAYLKI 3546
Query: 1162 -------------SVVAKEVKKA-----PVILEKLQNCGVPEGHPVRLECRVIGMPPPVF 1203
S VAK ++K P L++L+ +G P E V+G P P
Sbjct: 3547 NSKGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTV 3606
Query: 1204 YWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
W K+N+ + CT ++ + G ++ ++ D+G Y A+N G +C A L
Sbjct: 3607 TWFKENKQL-CTSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAEL 3663
Score = 100 bits (249), Expect = 9e-21
Identities = 97/368 (26%), Positives = 142/368 (38%), Gaps = 77/368 (20%)
Query: 173 IRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQE 232
+R R+ K +E Q V++ + D+ + + I R V +E++
Sbjct: 3101 VRIRSIKKEVQVIEKQRAVVEFEVNE-DDVDAHWYKDGIEINFQVQERHKYV---VERRI 3156
Query: 233 AKRREAEQAASEAAGGDTTPGSSPSS--LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+ +E S+A G + SS LY P +PP+ Q+L+ V G +
Sbjct: 3157 HRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAP--EPPQVLQELQPVTVQSGKPARFCA 3214
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
++ G P P++ WY E + L + G ++L + EAF ED Y+C A N YG
Sbjct: 3215 VISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVA 3274
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRV 410
+TSA + +E EV SP V PPA+
Sbjct: 3275 TTSASLSVE---------------------VPEVVSPDQEMPVYPPAI------------ 3301
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYR 470
LQ+ SEGQ F+CRV G KV WY
Sbjct: 3302 ---------------------------ITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYS 3333
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+ I+ S FR M + E+ L IAE + ED G +T ASN G VSS A L
Sbjct: 3334 KDKKIKPSRFFR--------MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANL 3385
Query: 531 HVRGNEDL 538
+ E +
Sbjct: 3386 SLEAPESI 3393
Score = 98.2 bits (243), Expect = 5e-20
Identities = 131/585 (22%), Positives = 217/585 (37%), Gaps = 90/585 (15%)
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
+ E H+ E Q +K E + SE+ T + E G P F +++ + ++
Sbjct: 3417 EEEGLHSAELQLSKINETLELLSESPVYPTK--------FDSEKEGTGPIFIKEVSNADI 3468
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
G L V+GIP P+++W+ G L S D V G+ HSL I ED G Y+
Sbjct: 3469 SMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFVFDGDDHSLIILFTKLEDEGEYT 3528
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C ASN YG SA + I +S EG + E + + K E P
Sbjct: 3529 CMASNDYGKTICSAYLKI----NSKGEGHKDTETESAVAKSLEKLGGP------------ 3572
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
P F K L+ + ++G +FE V G
Sbjct: 3573 --------------------------------CPPHFLKELKPIRCAQGLPAIFEYTVVG 3600
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P+P V W++E + S + I+ P T ++ + EDSG + C A N
Sbjct: 3601 EPAPTVTWFKENKQLCTSVYYTIIH-------NPNGSGTFIVNDPQREDSGLYICKAENM 3653
Query: 521 YGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEG 580
G + A+L V ED + A ST A E P P + P+VE +
Sbjct: 3654 LGESTCAAELLVL-LEDTDMTDTPCKAKSTPE--APEDFPQTP-LKGPAVEALDSEQEIA 3709
Query: 581 VLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSE--------AGVVTTRQTRPDSFQE-- 630
V +++ + K +E SS+ ++ + P+S +E
Sbjct: 3710 TFVKDTILKAALITEENQQLSYEHIAKANELSSQLPLGAQELQSILEQDKLTPESTREFL 3769
Query: 631 RFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPF 690
NG P+KEP P L + S + ++ E+ + Q + K FP
Sbjct: 3770 CINGSI-----HFQPLKEPSPNLQLQIVQSQKTFSKEGILMPEEPETQAVLSDTEKIFPS 3824
Query: 691 SMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSST 750
+M++ N+ + + + S P T+ ++P V +
Sbjct: 3825 AMSIEQINSLTVEPLKTLLAEPEGNYPQSSIEPPMHSYLTSVAEEVLSPKEKTVSDTNRE 3884
Query: 751 PQ-TIQRTVSKESLLVSH-------PSVQTKSPGGLSIQNEPLPP 787
+ T+Q+ ++ +L++S S+Q+ + EPL P
Sbjct: 3885 QRVTLQKQEAQSALILSQSLAEGHVESLQSPDVMISQVNYEPLVP 3929
Score = 94.4 bits (233), Expect = 7e-19
Identities = 83/306 (27%), Positives = 132/306 (43%), Gaps = 36/306 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L+ EG + C V G +V WY + K+++ S + Q + + L
Sbjct: 3298 PPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLE 3356
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
IAEA+ ED G Y+ ASN G S++A + +E S E RI++ E+
Sbjct: 3357 IAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHE---------RIEQEIEMEMK 3407
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQ-----CQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
+S+ + A + H A+ +++ I + +SP Y D + P+F K +
Sbjct: 3408 EFSSSFL-SAEEEGLH-SAELQLSKINETLELLSESPV-YPTKFDSEKEGTGPIFIKEVS 3464
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
N S G + V G P PK++W+ G L+ S D++ + + +L+I
Sbjct: 3465 NADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADYKFV--------FDGDDHSLII 3516
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHV----RGNEDLSNNGSLHSANSTTNLAAIEP 558
ED G +TC ASN YG A L + G++D ++ A S L
Sbjct: 3517 LFTKLEDEGEYTCMASNDYGKTICSAYLKINSKGEGHKDTETESAV--AKSLEKLGG--- 3571
Query: 559 QPSPPH 564
P PPH
Sbjct: 3572 -PCPPH 3576
Score = 94.0 bits (232), Expect = 9e-19
Identities = 71/255 (27%), Positives = 112/255 (43%), Gaps = 37/255 (14%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + L+ V EGS TF I G PVP+V WF+DG+ IS DG
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + T + G Y++ A N G+ + + L+V++ +
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKA-----------------------ET 101
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
P P+F+Q M +G RL +V+G+P P + + +G + + +
Sbjct: 102 AP-------PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQ-IS 153
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE---VKKAPVILEKLQN 1180
+E ++SLLI D+GTY ATN G+ + + EL V +E KK I+ Q
Sbjct: 154 QEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQ- 212
Query: 1181 CGVPEGHPVRLECRV 1195
+ E R+E ++
Sbjct: 213 --ISESRQTRIEKKI 225
Score = 91.7 bits (226), Expect = 4e-18
Identities = 58/165 (35%), Positives = 88/165 (53%), Gaps = 12/165 (7%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F Q+L+S V +G++V+L V GIP P V++Y +G E+++S D I Q G+L+SL
Sbjct: 103 PPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL 162
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG--------VSSSDSEGDPNKEEMNRIQ 379
IAEA+ ED+G YS A+N G +++AE+ ++G + S ++ RI+
Sbjct: 163 IAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIE 222
Query: 380 KPNE----VSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
K E S T VI A Q PR+ + +SPT
Sbjct: 223 KKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRIPPKPKSRSPT 267
Score = 90.5 bits (223), Expect = 1e-17
Identities = 91/376 (24%), Positives = 143/376 (38%), Gaps = 70/376 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V EG F+C G PVP V W + G+ +S H + T I S + D+G
Sbjct: 26075 VYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKST--FEISSVQASDEG 26132
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG---QSHRGRSRVQERDKEPLQERFFR 1072
NY+++ N +G+ L +Q + + ++ +S R + E K P + +
Sbjct: 26133 NYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPE 26192
Query: 1073 PHFLQA---------PGDMVAH-----------------EGRLCRLDCKV--SGLPPPEL 1104
P +A P + V H + +L C V S L E+
Sbjct: 26193 PSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEV 26252
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL----- 1159
TW +G+ + + + G + L I+ LT+ D G Y C + + G + +L
Sbjct: 26253 TWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQ 26312
Query: 1160 -----------------------ELSVVAKEVKKA-------PVILEKLQNCGVPEGHPV 1189
E +V K KA PVI+ LQ+ V
Sbjct: 26313 AFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVA 26372
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+ + G P P W KD + I + + +D G+ L I SD+G YT + K
Sbjct: 26373 KFAVKATGEPRPTAIWTKDGKAI-TQGGKYKLSEDKGGF-FLEIHKTDTSDSGLYTCTVK 26430
Query: 1250 NEAGIVSCTARLDIYA 1265
N AG VS + +L I A
Sbjct: 26431 NSAGSVSSSCKLTIKA 26446
Score = 89.4 bits (220), Expect = 2e-17
Identities = 70/308 (22%), Positives = 131/308 (42%), Gaps = 43/308 (13%)
Query: 259 LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV 318
L + L P F + RS+ + EG V C + G P P++ W+ + S ++ I
Sbjct: 26627 LTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSIS 26686
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI---------------EGVSS 363
++ N++SL I A D+G+Y+ A N G S +A + + G +S
Sbjct: 26687 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTS 26746
Query: 364 SDSEGDPNKEEMNRIQKPNEVSSPPTTSA----VIPPAVPQAQHLVAQPR---------- 409
+M+ ++ SS ++SA + A AQ + +
Sbjct: 26747 LQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSF 26806
Query: 410 --VATIQQCQSPTNYL--QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
++ + Q +S T+ + G+ G P P + ++S EG+++ C G P+P+
Sbjct: 26807 MGISNMTQLESSTSKMLKAGIRGIP----PKIEALPSDISIDEGKVLTVACAFTGEPTPE 26862
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
V W G I R + +++ TL+I +V +D G +T + N++G+ S
Sbjct: 26863 VTWSCGGRKIHSQEQGRF------HIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 26916
Query: 526 SIAQLHVR 533
+ +H+R
Sbjct: 26917 ATVNIHIR 26924
Score = 88.6 bits (218), Expect = 4e-17
Identities = 101/387 (26%), Positives = 143/387 (36%), Gaps = 79/387 (20%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F K +K +V E F C+ V P V W KD +++ + + K+++E L I
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECE-VSEPDITVQWMKDDQEL-QITDRIKIQKE-KYVHRLLI 3070
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR--------- 1057
ST D G YT++A G +S + L V+ +R R + R
Sbjct: 3071 PSTRMSDAGKYTVVAG---GNVS-TAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNE 3126
Query: 1058 -----------------VQERDKEPLQERFFR---------------------------- 1072
VQER K ++ R R
Sbjct: 3127 DDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLY 3186
Query: 1073 ------PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P LQ + G+ R +SG P P+++W Q + K L +
Sbjct: 3187 VNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFL-HDG 3245
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA--------PVILEKL 1178
++LL+ DA Y C A N G + S LSV EV P I+ L
Sbjct: 3246 QEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPL 3305
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ EG P R +CRV G V ++ KD + P R++ +DT L I A
Sbjct: 3306 QDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQ---LEIAEAYP 3362
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYA 1265
D G YT A N G VS TA L + A
Sbjct: 3363 EDEGTYTFVASNAVGQVSSTANLSLEA 3389
Score = 87.8 bits (216), Expect = 6e-17
Identities = 61/246 (24%), Positives = 113/246 (45%), Gaps = 14/246 (5%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
PIF K + + ++ G T + ++GIP PK+ WF +G ++ ++ K +GD SL
Sbjct: 3457 PIFIKEVSNADISMGDVATLSVTVIGIPKPKIQWFFNGVLLTPSADY-KFVFDGDDH-SL 3514
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T +D+G YT MA+N G+ CS +L ++ S G+ H+ + + +
Sbjct: 3515 IILFTKLEDEGEYTCMASNDYGKTICSAYL---------KINSKGEGHKD-TETESAVAK 3564
Query: 1065 PLQERF--FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
L++ PHFL+ + +G + V G P P +TW + + + ++
Sbjct: 3565 SLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPTVTWFKENKQLCTSVYYTII 3624
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
G + +++ + D+G Y C A N G+++ + EL V+ ++ +
Sbjct: 3625 HNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLVLLEDTDMTDTPCKAKSTPE 3684
Query: 1183 VPEGHP 1188
PE P
Sbjct: 3685 APEDFP 3690
Score = 87.8 bits (216), Expect = 6e-17
Identities = 63/213 (29%), Positives = 86/213 (40%), Gaps = 25/213 (11%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GTCSLHIESTTSDDDGNY 1017
G V F I P P V W+K G++I + K E D G L I S T+DDD Y
Sbjct: 25207 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 25266
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
T++A N G SC L V P P + RP F +
Sbjct: 25267 TVVARNKYGEDSCKAKLTVTLHP------------------------PPTDSTLRPMFKR 25302
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
+ EG+ + +VSG+PPP L W +GQP+ + +++ ++L I
Sbjct: 25303 LLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTL 25362
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK 1170
D G Y+ ATN G S L V KK
Sbjct: 25363 PEDTGYYRVTATNTAGSTSCQAHLQVERLRYKK 25395
Score = 86.7 bits (213), Expect = 1e-16
Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 9/202 (4%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR-ETGVHSL 1131
P F Q +V EG + +SG P PE++W +GQ + + + G L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I +T+ ++G Y ATN +GQ + + EL V A+ P +++LQ+ V +G VRL
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAP--PNFVQRLQSMTVRQGSQVRL 123
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ RV G+P PV + +D I + + +IS D LLI A D+G Y+++A N
Sbjct: 124 QVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYS---LLIAEAYPEDSGTYSVNATN 180
Query: 1251 EAGIVSCTARLDIYAQWHHQIP 1272
G + TA ++ Q ++P
Sbjct: 181 SVGRATSTA--ELLVQGEEEVP 200
Score = 86.3 bits (212), Expect = 2e-16
Identities = 74/273 (27%), Positives = 121/273 (44%), Gaps = 21/273 (7%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--DIHIVQAGNLHSLTI 328
F ++++ + EG V C + G P P++ WY +GK +++ + +Q G SL I
Sbjct: 1247 FDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRA-SLRI 1305
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEG-DPNKEEMNRIQ--KPNEVS 385
ED G Y+ FASNI G S ++Y+E + + P E ++RI+ P VS
Sbjct: 1306 PVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVS 1365
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI--IAAPVFTKMLQN 443
P + P + A+ A+ A + SP L+ D + + PVF +
Sbjct: 1366 RSPIRMS--PARMSPARMSPARMSPARM----SPGRRLEETDESQLERLYKPVFVLKPVS 1419
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
EGQ F+ +V G P P+ W+ +G I + +++ K+ + +L+I
Sbjct: 1420 FKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQ-------SLIIV 1472
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
DSG +T A N+ G S L V E
Sbjct: 1473 PATPSDSGEWTVVAQNRAGRSSISVILTVEAVE 1505
Score = 85.1 bits (209), Expect = 4e-16
Identities = 98/451 (21%), Positives = 166/451 (36%), Gaps = 60/451 (13%)
Query: 193 QENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTP 252
QE + + R +V P + + V + KR ++ + + A T
Sbjct: 26145 QEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTET 26204
Query: 253 GSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG--IPPPQVRWYCEGKELE 310
+P+ P+ PP+ TQ L++ E + L C+V + +V WY +GK+L+
Sbjct: 26205 KPTPTEKVQHLPVSAPPKITQFLKAEASKEIAK--LTCVVESSVLRAKEVTWYKDGKKLK 26262
Query: 311 NSPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGD 369
+ A + L I E D G Y C S GT T+ + + S
Sbjct: 26263 ENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIH---- 26318
Query: 370 PNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK 429
E++++I + + T S V P+A +
Sbjct: 26319 ---EKVSKISETKKSDQKTTESTVTRKTEPKAP--------------------------E 26349
Query: 430 PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
PI + PV LQ+ + S + F + G P P W ++G I +++ + K
Sbjct: 26350 PISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGG 26409
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANS 549
E I + DSG +TCT N G+VSS +L ++ +D S
Sbjct: 26410 FFLE--------IHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTE-----AQKVS 26456
Query: 550 TTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFN---LPEDD 606
T + I PQ E S + L + +E +S ++ L+ + + E+
Sbjct: 26457 TQKTSEITPQKKAVVQEEIS-----QKALRSEEIKMSEAKSQEKLALKEEASKVLISEEV 26511
Query: 607 KGSEASS-EAGVVTTRQTRPDSFQERFNGQA 636
K S A+S E +V T+ E A
Sbjct: 26512 KKSAATSLEKSIVHEEITKTSQASEEVRTHA 26542
Score = 84.7 bits (208), Expect = 5e-16
Identities = 98/385 (25%), Positives = 159/385 (41%), Gaps = 73/385 (18%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD-GT 1001
+ P+F ++LK+ + EGS + + G P P + W K+ I +++ K+R EG G
Sbjct: 1508 VKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNS-DIIVPHKYPKIRIEGTKGE 1566
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRIS--CSGHLMVQSL---PIRSRLTSAGQSHRGRS 1056
+L I+ST S D YT A N GR + C ++ V+ P R + G ++R +
Sbjct: 1567 AALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRG-TYRAKE 1625
Query: 1057 RVQERDKEPLQERFFRPHFLQAPGDMVAHEG-------------RLCRL-----DCKVSG 1098
+ + EPL R+ + + + GD+ E RL R +C+++
Sbjct: 1626 -IAAPELEPLHLRYGQEQWEE--GDLYDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTP 1682
Query: 1099 LPPPELT--WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNS 1156
+ P + WL +G+P L A+ ++ E G SL RD+G C ATNK G +
Sbjct: 1683 IGDPTMVVEWLHDGKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDH 1741
Query: 1157 FSLELSV--------------------------------------VAKEVKKAPVILEKL 1178
S L V ++ K+ P I+
Sbjct: 1742 TSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYP 1801
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ V EG R CRV G P P W + + I ++ R + D Y L I K
Sbjct: 1802 EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK-RFRVRYDGIHY--LDIVDCKS 1858
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDI 1263
D G ++A+N G++ +L+I
Sbjct: 1859 YDTGEVKVTAENPEGVIEHKVKLEI 1883
Score = 84.7 bits (208), Expect = 5e-16
Identities = 67/235 (28%), Positives = 97/235 (41%), Gaps = 16/235 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKI--VGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
P F K+L R+ P F C++ +G P V W DGK + N +M E G C
Sbjct: 1657 PFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANR-LRMINEF-GYC 1714
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL S D G T A N G S L+V+ + + +G R++E +
Sbjct: 1715 SLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELE 1774
Query: 1063 KEPL----------QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ Q+ +P + P + EG R C+V+G P P++ W LNGQ
Sbjct: 1775 RMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ- 1833
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
L S + VR G+H L I D G K A N G ++L + +E
Sbjct: 1834 -LIRKSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRE 1887
Score = 84.3 bits (207), Expect = 7e-16
Identities = 76/282 (26%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 261 YEEPLGQPPRFTQKLRSREVPEGTRVQLDCIV--VGIPPPQVRWYCEGKELENSPDIHIV 318
Y++ Q P F +KL S + +C + +G P V W +GK LE + + ++
Sbjct: 1649 YDKEKQQKPFFKKKLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMI 1708
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS--SDSEGDPNKEEMN 376
SL A+ D+G +C A+N YGTD TSA + ++ S +S+ ++ +
Sbjct: 1709 NEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQ 1768
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ-QCQSPTNYLQGLDGKPIIAAP 435
RI++ + + H A V T Q + Q P I+ P
Sbjct: 1769 RIEE-----------------LERMAHEGALTGVTTDQKEKQKP----------DIVLYP 1801
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
++L EG+ F CRV G P PKV WY G LI S FR+ +
Sbjct: 1802 EPVRVL------EGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRV---------RYD 1846
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
I L I + + D+G TA N G + +L ++ ED
Sbjct: 1847 GIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQRED 1888
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/120 (39%), Positives = 64/120 (53%), Gaps = 8/120 (6%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
+ P L+N++ EG+ V EC + G PSP V WYRE IE S DF+I +
Sbjct: 894 VTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ----- 948
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTT 551
I L+I E FAEDSG FTC+A N+ GTVS+ L V+ +E+ + + TT
Sbjct: 949 ---SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTT 1005
Score = 82.0 bits (201), Expect = 3e-15
Identities = 79/338 (23%), Positives = 131/338 (38%), Gaps = 46/338 (13%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L PR T ++RS VP G + V P +V+WY G EL+ S IH +
Sbjct: 25873 LDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVL 25932
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN-- 382
+L I + +D+G Y +N G S A + + G + EE+ R P
Sbjct: 25933 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELT 25992
Query: 383 -----EVSSPPTTSAV-IPPAVPQAQHLVAQPR--VATIQQCQSPTNYLQGLDGKPI--- 431
VSS TS + +V + + + + R +++ + S L+ K +
Sbjct: 25993 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 26052
Query: 432 ---------IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+AA + TK ++++ EG+ F C G P P V W R+G ++ S +
Sbjct: 26053 STTRKIKTTLAARILTKP-RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ 26111
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ K +S T I+ V A D G ++ N G ++
Sbjct: 26112 VTTTKYKS--------TFEISSVQASDEGNYSVVVENS------------EGKQEAEFTL 26151
Query: 543 SLHSANSTTNLAAIEPQ---PSPPHSEPPSVEQPPKPK 577
++ A T P+ P P P +V+ P + K
Sbjct: 26152 TIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVK 26189
Score = 79.0 bits (193), Expect = 3e-14
Identities = 93/374 (24%), Positives = 153/374 (40%), Gaps = 67/374 (17%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
A P F + LQ+++ +G V + RV G P+P V++YR+G I+ S DF+I Q+
Sbjct: 102 APPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQE------ 155
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED--------LSNNGSL 544
++ +L+IAE + EDSG ++ A+N G +S A+L V+G E+ + + +
Sbjct: 156 --GDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQI 213
Query: 545 HSANST------------TNLAAIE------PQPSPPHSEPPSVEQPPKPKLE-----GV 581
+ T ++A +E PH PP + PPKPK +
Sbjct: 214 SESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPPRI--PPKPKSRSPTPPSI 271
Query: 582 LVNHNEPRSSSRIGLR------VHFNLPEDDKGSEASSEAGVVTT--RQTRPDSFQERFN 633
R S +R H P S A + T+ R R +
Sbjct: 272 AAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQ 331
Query: 634 GQATKT-PEPSSPVKEPPPVLAKPKLDS-----TQLQQLHNQVLLE-QHQLQNPPP-SSP 685
T PE P K+ V + + + T Q+ + E ++ +Q S
Sbjct: 332 ASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTTSTQIRTEERWEGRYGVQEQVTISGA 391
Query: 686 KEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVF 745
S++ S A AV T +K+VK + ++ ++A T A +A PV
Sbjct: 392 AGAAASVSASASYAAEAVATGAKEVKQDADKSAAVA--------TVVAAVDMARVREPV- 442
Query: 746 TLSSTPQTIQRTVS 759
+S+ QT QRT +
Sbjct: 443 -ISAVEQTAQRTTT 455
Score = 78.2 bits (191), Expect = 5e-14
Identities = 63/231 (27%), Positives = 93/231 (40%), Gaps = 16/231 (6%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P LK+ V EG VT C I G P P V W+++ QI + G L
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDF--QITFQSGIARL 954
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ--------SLPIRSRLTSAGQSHRGRS 1056
I ++D G +T A N G +S S +L VQ + + + T+ +
Sbjct: 955 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1014
Query: 1057 RVQERDKEPLQERF-----FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQ 1111
V D +E+ P+F+ P EG C+V G P P + W +G
Sbjct: 1015 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1074
Query: 1112 PVLPDASHKMLV-RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P+ +K+ ++TG L+I DAG Y + NK G+ S S L
Sbjct: 1075 PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 77.8 bits (190), Expect = 6e-14
Identities = 70/281 (24%), Positives = 114/281 (40%), Gaps = 35/281 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSL 326
P F +KL++ + EG+R+++ G P P + W + P I I +L
Sbjct: 1510 PMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAAL 1569
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I +D+ Y+ A N G D+T ++ +E V ++ E
Sbjct: 1570 KIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE-VEFAEPE------------------- 1609
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-LDGKPIIAAPVFTKMLQNLS 445
P +IP +A+ + A P + + + +G L K P F K L +L
Sbjct: 1610 -PERKLIIPRGTYRAKEIAA-PELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLR 1667
Query: 446 ASEGQLVVFECRVK--GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
FECR+ G P+ VEW +G +E + R++ + C+L
Sbjct: 1668 LKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFG--------YCSLDYG 1719
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSL 544
++ DSG TC A+NKYGT + A L V+ + L L
Sbjct: 1720 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKSLVEESQL 1760
Score = 75.1 bits (183), Expect = 4e-13
Identities = 83/355 (23%), Positives = 139/355 (39%), Gaps = 50/355 (14%)
Query: 820 TSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNT--KSPQPVNDDNIR 877
T I +P+ S V+ P P AP P+ K++ + +P D
Sbjct: 24306 TFGISDPLEVSSVVIIKSPFEKP--------GAPGKPTITAVTKDSCVVAWKPPASDGGA 24357
Query: 878 ETKNAVIRDLGKK------ITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDE 931
+ +N + KK +T ++R + + + + + L E + E + E
Sbjct: 24358 KIRNYYLEKREKKQNKWISVTTEEIR--ETVFSVKNLIEGLEYEFRVKCENLGGESEWSE 24415
Query: 932 IQHDEIPTGKCI--APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRN 989
I P AP F + L++ V S T CK+ G P P V W++ GK+I
Sbjct: 24416 ISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADG 24475
Query: 990 EHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG 1049
+++ G L I S T DD Y + A N G +S + L V+ +P + L
Sbjct: 24476 LKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVE-VPAKIHL---- 24530
Query: 1050 QSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
P L+ G + A G + + SG P P +TW
Sbjct: 24531 -----------------------PKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITW-QK 24566
Query: 1110 GQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
GQ ++ + H ++ SL+ + + ++DAG Y A N+ G + ++EL V
Sbjct: 24567 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 24621
Score = 74.3 bits (181), Expect = 7e-13
Identities = 64/238 (26%), Positives = 107/238 (44%), Gaps = 37/238 (15%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP K +K G +C+IVG P+P + W++ GK++ + ++ KM +G T +
Sbjct: 24035 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKY-KMSSDG-RTHT 24092
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L + + +D+G YT +A N G + S L++Q+ P Q H G
Sbjct: 24093 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATP---------QFHPG--------- 24134
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
PL+E+++ G RL G P P +TW +GQ +L + S + +
Sbjct: 24135 YPLKEKYY------------GAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQN-SENITI 24180
Query: 1124 RETGVHSLLIDPLTQR--DAGTYKCIATNKTGQNSFSLELSVVAKEVK-KAPVILEKL 1178
T ++ L+ QR AG YK +N G L++ + K K P+++E L
Sbjct: 24181 ENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEAL 24238
Score = 74.3 bits (181), Expect = 7e-13
Identities = 79/326 (24%), Positives = 123/326 (37%), Gaps = 44/326 (13%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + + + EG V FTC+I G P P++ WFK+ IS + R S
Sbjct: 26636 APAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSR--NVYS 26693
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL---PIRSRL--TSAGQSHRGRSRV 1058
L I + + D G YTI A N +G+ S + LMV L P R + TS S +G
Sbjct: 26694 LEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSS 26753
Query: 1059 QE-RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA 1117
Q + QE F + M + K + + ++ +
Sbjct: 26754 QSVQMSASKQEASFSSFSSSSASSMT---------EMKFASMSAQSMS-----------S 26793
Query: 1118 SHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEK 1177
+ V + + I +TQ ++ T K + G + +++ P
Sbjct: 26794 MQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRG----------IPPKIEALP----- 26838
Query: 1178 LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAK 1237
+ + EG + + C G P P W I + ++T L+I +
Sbjct: 26839 -SDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQ 26897
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
K D G YTLS NE G S T + I
Sbjct: 26898 KQDGGLYTLSLGNEFGSDSATVNIHI 26923
Score = 73.9 bits (180), Expect = 9e-13
Identities = 57/210 (27%), Positives = 90/210 (42%), Gaps = 8/210 (3%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA-SHKMLVRETGVHSL 1131
PHF + ++ L CKV+G P P + W G+ ++ D +++ + G H L
Sbjct: 24431 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 24490
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
+I +T DA Y+ ATN+ G S + L V P LE + G V +
Sbjct: 24491 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 24550
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ G P PV W+K + I + + + + ++ DAG+Y + AKN
Sbjct: 24551 KIPFSGKPDPVITWQKGQDLID-NNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNR 24609
Query: 1252 AGIVSCTARLDIYAQWHHQIP-PPMSVRPS 1280
GI T LD+ +P PP V+ S
Sbjct: 24610 FGIDQKTVELDV-----ADVPDPPRGVKVS 24634
Score = 72.8 bits (177), Expect = 2e-12
Identities = 64/237 (27%), Positives = 111/237 (46%), Gaps = 9/237 (3%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
M +EG+ L ++G ++ W+LNG + ++ V + +L I + RD
Sbjct: 26551 MSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSD-QTLTIKQASHRDE 26607
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPP 1201
G CI+ K G +L++ +KE+ AP + + ++ + EG V C + G P P
Sbjct: 26608 GILTCISKTKEGIVKCQYDLTL-SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26666
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
W K+N I + +S+ + Y+ L I+ A SD+G YT+ AKN G S TA L
Sbjct: 26667 EIEWFKNNLPISIS-SNVSISRSRNVYS-LEIRNASVSDSGKYTIKAKNFRGQCSATASL 26724
Query: 1262 DIYAQWHHQIPPPMSVRPSG--SRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVE 1316
+ + + +R SG S GS +S+ + + ++ + S S+ S+ E
Sbjct: 26725 -MVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTE 26780
Score = 71.6 bits (174), Expect = 5e-12
Identities = 56/184 (30%), Positives = 86/184 (46%), Gaps = 9/184 (4%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
D V+ EG + L ++ E+ W + V D K L ++ ++L+ID + D
Sbjct: 4251 DTVSEEGDIVHLTTSITNAK--EVNWYFENKLVPSDEKFKCL-QDQNTYTLVIDKVNTED 4307
Query: 1141 -AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMP 1199
G Y C A N +G+ + S +L+VV + APVI K++ V GH + C + P
Sbjct: 4308 HQGEYVCEALNDSGKTATSAKLTVVKRA---APVIKRKIEPLEVALGHLAKFTCEIQSAP 4364
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTA 1259
F W K I ++ S+ + + + L I + D G YT A NE G VSCTA
Sbjct: 4365 NVRFQWFKAGREI-YESDKCSI-RSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTA 4422
Query: 1260 RLDI 1263
L +
Sbjct: 4423 TLTV 4426
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/115 (32%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 938 PTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE 997
PT + P+F + L + EG V F ++ GIP P + W KDG+ +S + ++ E
Sbjct: 25291 PTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLS-LGPNIEIIHE 25349
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSH 1052
G +LHI T +D G Y + A N G SC HL V+ L + + + + H
Sbjct: 25350 GLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEH 25404
Score = 68.6 bits (166), Expect = 4e-11
Identities = 76/309 (24%), Positives = 132/309 (42%), Gaps = 42/309 (13%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S ++LY E + F + ++ +V E R +C V P V+W + +EL+ +
Sbjct: 3000 TSTATLYVE---ARHIEFRKHIKDIKVLEKKRAMFEC-EVSEPDITVQWMKDDQELQITD 3055
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
I I + +H L I D G+Y+ A G + ++A++++EG D K+
Sbjct: 3056 RIKIQKEKYVHRLLIPSTRMSDAGKYTVVA----GGNVSTAKLFVEG---RDVRIRSIKK 3108
Query: 374 EMNRIQKPNEVSSPPTTSAVIPP-----------AVPQAQHLVAQPRV------ATIQQC 416
E+ I+K V + V + V + R+ T Q
Sbjct: 3109 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSD 3168
Query: 417 QSPTNYLQGLDGKPI---IAAPVFTKMLQNL---SASEGQLVVFECRVKGAPSPKVEWYR 470
++ G + + + AP ++LQ L + G+ F + G P PK+ WY+
Sbjct: 3169 AGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYK 3228
Query: 471 EGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
E L+ S F K + + + +E TL++ E F ED+ +TC A N YG ++ A L
Sbjct: 3229 EEQLL--STGF-----KCKFLHDGQEY-TLLLIEAFPEDAAVYTCEAKNDYGVATTSASL 3280
Query: 531 HVRGNEDLS 539
V E +S
Sbjct: 3281 SVEVPEVVS 3289
Score = 66.6 bits (161), Expect = 1e-10
Identities = 86/381 (22%), Positives = 144/381 (37%), Gaps = 77/381 (20%)
Query: 697 SNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQR 756
S A A+ T K++ A SS K + T P+ P F + TP T +
Sbjct: 787 SIAGSAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPLPQFPFADTPDTYK- 845
Query: 757 TVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIP 816
S V+ K G+SI T T F + G + +
Sbjct: 846 ---------SEAGVEVKKEVGVSI---------TGTTVREERFEVLHGREAK-------- 879
Query: 817 VSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPR------------------SAPSMP-- 856
V+ T+R+ PV +P PPT GL +P++
Sbjct: 880 VTETARVPAPV--------EIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWY 931
Query: 857 ----------------SQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT--FSDVRP 898
G+A+ + + +D+ R T +AV + G T + V+
Sbjct: 932 REDYQIESSIDFQITFQSGIARLMIR--EAFAEDSGRFTCSAV-NEAGTVSTSCYLAVQV 988
Query: 899 NQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVT 957
+++ E + ++ ++ E + +E V +D + ++ G+ AP F + ++
Sbjct: 989 SEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLV 1048
Query: 958 EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
EG V F C++ G P P VYW K G ++ + + G C L I T +DD G Y
Sbjct: 1049 EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEY 1108
Query: 1018 TIMAANPQGRISCSGHLMVQS 1038
TI+ N G S S L+ ++
Sbjct: 1109 TIVVRNKHGETSASASLLEEA 1129
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 1/132 (0%)
Query: 243 SEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
+E G + P + S+ + G+ P ++++ G QL C +VG P P ++W
Sbjct: 24010 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKW 24069
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
Y GKEL S + G H+LT+ +ED G Y+C A+N G TS+++ ++ +
Sbjct: 24070 YRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ-AT 24128
Query: 363 SSDSEGDPNKEE 374
G P KE+
Sbjct: 24129 PQFHPGYPLKEK 24140
Score = 66.2 bits (160), Expect = 2e-10
Identities = 37/113 (32%), Positives = 57/113 (50%), Gaps = 1/113 (0%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-NLHSLT 327
P F + L + E EG V + V GIPPP ++W +G+ L P+I I+ G + ++L
Sbjct: 25298 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 25357
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
I + EDTG Y A+N G+ S A + +E + E +E +QK
Sbjct: 25358 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEEHERHVQK 25410
Score = 65.5 bits (158), Expect = 3e-10
Identities = 65/256 (25%), Positives = 102/256 (39%), Gaps = 50/256 (19%)
Query: 1052 HRGRSRVQE--RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLN 1109
H ++V E R P++ P + ++ EG L+C +SG P P +TW
Sbjct: 874 HGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYRE 933
Query: 1110 GQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEV 1168
+ ++ ++G+ L+I D+G + C A N+ G S S L+V V++E
Sbjct: 934 DYQIESSIDFQITF-QSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF 992
Query: 1169 KK----------------------------------------APVILEKLQNCGVPEGHP 1188
+K AP + K + EG
Sbjct: 993 EKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGS 1052
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCT---RERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
V C+V G P P YWKK +P T R ++S ++ TG L+I DAG YT
Sbjct: 1053 VVFGCQVGGNPKPHVYWKKSG--VPLTTGYRYKVSYNKQ-TGECKLVISMTFADDAGEYT 1109
Query: 1246 LSAKNEAGIVSCTARL 1261
+ +N+ G S +A L
Sbjct: 1110 IVVRNKHGETSASASL 1125
Score = 65.5 bits (158), Expect = 3e-10
Identities = 63/268 (23%), Positives = 95/268 (35%), Gaps = 68/268 (25%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L +PP FT L ++ G V+ + P P V WY G++++ N
Sbjct: 25189 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIK--------PGDNDK 25240
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
T FE D G Y +++ D + DS K ++ P
Sbjct: 25241 KYT----FESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDS----CKAKLTVTLHP--- 25289
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
PPT S + P+F ++L N
Sbjct: 25290 --PPTDSTL----------------------------------------RPMFKRLLANA 25307
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
EGQ V FE RV G P P ++W ++G + P+ I+ E + L I +
Sbjct: 25308 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIH-------EGLDYYALHIRD 25360
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
ED+G + TA+N G+ S A L V
Sbjct: 25361 TLPEDTGYYRVTATNTAGSTSCQAHLQV 25388
Score = 64.7 bits (156), Expect = 6e-10
Identities = 62/220 (28%), Positives = 89/220 (40%), Gaps = 26/220 (11%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
+ L+ V G P F I G P PK+ W+K+ +Q+ CK +G L IE+
Sbjct: 3197 QELQPVTVQSGKPARFCAVISGRPQPKISWYKE-EQLLSTGFKCKFLHDGQEYTLLLIEA 3255
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
+D YT A N G + S L V+ + S P QE
Sbjct: 3256 FP-EDAAVYTCEAKNDYGVATTSASLSVEVPEVVS---------------------PDQE 3293
Query: 1069 RFFRPHFLQAP-GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P + P D V EG+ R C+VSG +++W + + P +M E
Sbjct: 3294 MPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFED- 3351
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
+ L I D GTY +A+N GQ S + LS+ A E
Sbjct: 3352 TYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPE 3391
Score = 64.7 bits (156), Expect = 6e-10
Identities = 52/211 (24%), Positives = 86/211 (40%), Gaps = 10/211 (4%)
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
+V W+KDGK++ K N H + DGT L I + T D G Y + G +
Sbjct: 26251 EVTWYKDGKKL-KENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQF 26309
Query: 1035 MVQSL-PIRSRLTSAGQSHRGRSRVQE----RDKEPL--QERFFRPHFLQAPGDMVAHEG 1087
M Q+ I +++ ++ + + E R EP + +P + D
Sbjct: 26310 MGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSD 26369
Query: 1088 RLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCI 1147
+ + K +G P P W +G+ + +K L + G L I D+G Y C
Sbjct: 26370 SVAKFAVKATGEPRPTAIWTKDGKAITQGGKYK-LSEDKGGFFLEIHKTDTSDSGLYTCT 26428
Query: 1148 ATNKTGQNSFSLELSVVA-KEVKKAPVILEK 1177
N G S S +L++ A K+ + V +K
Sbjct: 26429 VKNSAGSVSSSCKLTIKAIKDTEAQKVSTQK 26459
Score = 63.5 bits (153), Expect = 1e-09
Identities = 62/255 (24%), Positives = 104/255 (40%), Gaps = 44/255 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP +R++ V +GS F ++VG P P+ W+K+G +I +R++ D C
Sbjct: 2031 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI-ERSDRIYWYWPEDNVCE 2089
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I T++D + + A N G S L+VQ+ + +
Sbjct: 2090 LVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLIT-------------------- 2129
Query: 1064 EPLQERFFRPHFLQAPGDMVAHE-GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F Q D+VA E + +C+ S P ++ W +G V ++M
Sbjct: 2130 -----------FTQELQDVVAKEKDTMATFECETSE-PFVKVKWYKDGMEVHEGDKYRM- 2176
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQN 1180
+ VH L I + DA Y C+ + AK + + V+ +++LQ+
Sbjct: 2177 HSDRKVHFLSILTIDTSDAEDYSCVLVEDE-------NVKTTAKLIVEGAVVEFVKELQD 2229
Query: 1181 CGVPEGHPVRLECRV 1195
VPE + LEC V
Sbjct: 2230 IEVPESYSGELECIV 2244
Score = 63.5 bits (153), Expect = 1e-09
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 51/252 (20%)
Query: 282 EGTRVQLDCIVVGIPPP-QVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
EG V+ C + QV WY ++LENS I + L + + + D G Y
Sbjct: 25084 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYR 25143
Query: 341 CFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ 400
C N YG DS+ AE++++GV + + M +I++
Sbjct: 25144 CKVVNDYGEDSSYAELFVKGV--REVYDYYCRRTMKKIKR-------------------- 25181
Query: 401 AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKG 460
R T++ + P P FT L N +A G+ V F +
Sbjct: 25182 --------RTDTMRLLERP---------------PEFTLPLYNKTAYVGENVRFGVTITV 25218
Query: 461 APSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNK 520
P P V WY+ G I+ + K + + + L I V +D +T A NK
Sbjct: 25219 HPEPHVTWYKSGQKIKPGDN-----DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNK 25273
Query: 521 YGTVSSIAQLHV 532
YG S A+L V
Sbjct: 25274 YGEDSCKAKLTV 25285
Score = 62.0 bits (149), Expect = 4e-09
Identities = 76/296 (25%), Positives = 112/296 (37%), Gaps = 61/296 (20%)
Query: 433 AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMA 492
AAPV + ++ L + G L F C ++ AP+ + +W++ G I +S I K
Sbjct: 4335 AAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSK----- 4389
Query: 493 EPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTN 552
I +L I D G +TC ASN+YG+VS A L V ++
Sbjct: 4390 ---YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV----------TVPGGEKKVR 4436
Query: 553 LAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEAS 612
E +P P +P+ E V EP+ ++ P E
Sbjct: 4437 KLLPERKPEPKEEVVLKSVLRKRPEEEEPKV---EPKKLEKVKKPAVPEPPPPKPVEEV- 4492
Query: 613 SEAGVVTTRQTRPDSFQERFNGQATKTPE--PSSPVKEPPPVLAKPKLDSTQLQQLHNQV 670
E VT R ER + TK PE P+ P+ P P KPK ++
Sbjct: 4493 -EVPTVTKR--------ERKIPEPTKVPEIKPAIPLPAPEP---KPKPEA---------- 4530
Query: 671 LLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSK--QVKAPSSQTFSLARPK 724
+ + PPP P+ P + AP V K + KAP + A+PK
Sbjct: 4531 ---EVKTIKPPPVEPEPTPIA-------APVTVPVVGKKAEAKAPKEEA---AKPK 4573
Score = 60.8 bits (146), Expect = 8e-09
Identities = 81/357 (22%), Positives = 127/357 (35%), Gaps = 67/357 (18%)
Query: 266 GQP--PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV---QA 320
G+P P F K +++ EG V C V G P P V W G L + Q
Sbjct: 1031 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQT 1090
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG----VSSSDSEGDPNKEEMN 376
G L I+ F +D G Y+ N +G S SA + E + S E +
Sbjct: 1091 GEC-KLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTA 1149
Query: 377 RIQKPNEVSSPP-----------------------TTSAVIPPAVPQAQHLVAQPRVATI 413
+Q+P + P + V+ V + ++ I
Sbjct: 1150 FVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLI 1209
Query: 414 QQCQ-----SPTNYLQGLDGKPIIAAPV---------FTKMLQNLSASEGQLVVFECRVK 459
++ + + L DG+ +A + F ++N EG V F C++
Sbjct: 1210 KEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMS 1269
Query: 460 GAPSPKVEWYREGTLIEDSPDFRI--LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
G P PK+ WY++G I+ +++ LQ S+ P V ED G +T A
Sbjct: 1270 GYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIP---------VVLPEDEGIYTAFA 1320
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
SN G +L+V L + T + +EP P SV + P
Sbjct: 1321 SNIKGNAICSGKLYVEPAAPL---------GAPTYIPTLEPVSRIRSLSPRSVSRSP 1368
Score = 60.8 bits (146), Expect = 8e-09
Identities = 85/347 (24%), Positives = 134/347 (38%), Gaps = 61/347 (17%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
RV EG F C++ G P PKV W+ +G+ I K + R DG L I S D
Sbjct: 1805 RVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK---RFRVRYDGIHYLDIVDCKSYDT 1861
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G + A NP+G I L +Q Q RS V R EP RP
Sbjct: 1862 GEVKVTAENPEGVIEHKVKLEIQ------------QREDFRS-VLRRAPEP------RPE 1902
Query: 1075 F-LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV----LPDASHKMLVR----- 1124
F + PG + + + ++D V E+ L + + +P+ S ++ +
Sbjct: 1903 FHVHEPGKL---QFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRT 1959
Query: 1125 ETGVHSLLID---PLTQRDAGTYKCIATNKTGQNSFSLELS-----VVAKEVK------- 1169
E G + + ++D + + K ++ EL+ +A+E K
Sbjct: 1960 EEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFK 2019
Query: 1170 ----------KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+AP I E++Q+ V +G RV+G P P W K+ I +RI
Sbjct: 2020 PDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIE-RSDRI 2078
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ L+I+ D+ + A N AG S A L + A+
Sbjct: 2079 YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAK 2125
Score = 60.8 bits (146), Expect = 8e-09
Identities = 82/331 (24%), Positives = 126/331 (38%), Gaps = 67/331 (20%)
Query: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
D+S E+ E PT F + L+ VTE F+C++ V W+++G++I
Sbjct: 6313 DKSVAELLIIEAPTE------FVEHLEDQTVTEFDDAVFSCQL-SREKANVKWYRNGREI 6365
Query: 986 SKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
E K + E DG+ L I+ DD+ Y + + R L V+ +P+
Sbjct: 6366 K---EGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSR----ARLFVEEIPVE-- 6416
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERFFRP--HFLQAPGDMVAHEGRLCRLDCKVSGLPPP 1102
RP L+APG V L +
Sbjct: 6417 -------------------------IIRPPQDILEAPGADVVFLAELNK--------DKV 6443
Query: 1103 ELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELS 1162
E+ WL N V+ H+M+ E +H L I + RD G Y+ IA +K +
Sbjct: 6444 EVQWLRNNMVVVQGDKHQMM-SEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKL----- 6497
Query: 1163 VVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
E+ AP I Q+ V G P+ + P W K+NE P + + I
Sbjct: 6498 ----ELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENE--PLSTKTIDTT 6551
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ T + L AKK D G Y + +N+ G
Sbjct: 6552 AEQTSFRIL---EAKKGDKGRYKIVLQNKHG 6579
Score = 60.5 bits (145), Expect = 1e-08
Identities = 145/725 (20%), Positives = 229/725 (31%), Gaps = 133/725 (18%)
Query: 365 DSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
D+E E R + P+ VSS + S A + A Q S Y +
Sbjct: 25806 DTERRSPTPERTRPRSPSPVSSERSLSRFERSARFDIFSRYESMKAALKTQKTSERKY-E 25864
Query: 425 GLDGKPIIA--APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
L +P AP T +++ GQ F V+ P+ +V+WY G +++S
Sbjct: 25865 VLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIH 25924
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ TL I + +DSG + +N G S A L V G +
Sbjct: 25925 Y--------TNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGD------ 25970
Query: 543 SLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNL 602
T A+ P S P + + + SSS ++
Sbjct: 25971 -------YTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTE 26023
Query: 603 PEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQ 662
+ S S + + + S +E+ + KT + +L KP+
Sbjct: 26024 TRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR-------ILTKPR----- 26071
Query: 663 LQQLHNQVLLEQHQLQNPPPSSPKEFPFSM-----TVLNSNAPPAVTTSSKQVKAPSSQT 717
+ + E + + + P VL+++A VTT+ + S
Sbjct: 26072 -----SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 26126
Query: 718 FSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGG 777
+ Y N+ A FTL TIQ+ E + S P V++ P
Sbjct: 26127 QASDEGNYSVVVENSEGKQEAE-----FTL-----TIQKARVTEKAVTSPPRVKSPEPRV 26176
Query: 778 LSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSL 837
S + P P P P+ VSP PT
Sbjct: 26177 KSPEAVKSPKRVKSPEPS------------HPKAVSPTETKPT----------------- 26207
Query: 838 PAIPPTNAMGLPRSAPSMPSQGL---AKKNTKSPQPVNDDNIRETKNAVIRDLGKKIT-- 892
P LP SAP +Q L A K V + ++ K GKK+
Sbjct: 26208 ---PTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKEN 26264
Query: 893 ----FSDVRPNQQEYKISSFEQRLMNEI--------------------EFRLERTPVDES 928
F E KI++ + E F+ V +
Sbjct: 26265 GHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKI 26324
Query: 929 DDEIQHDEIPTGKCIA--------------PIFDKRLKHFRVTEGSPVTFTCKIVGIPVP 974
+ + D+ T + P+ L+ V+ S F K G P P
Sbjct: 26325 SETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRP 26384
Query: 975 KVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHL 1034
W KDGK I++ ++ E G L I T + D G YT N G +S S L
Sbjct: 26385 TAIWTKDGKAITQGGKY--KLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKL 26442
Query: 1035 MVQSL 1039
++++
Sbjct: 26443 TIKAI 26447
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/147 (31%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT ++ P + AP + +Q+ + +G F RV G P P+ EWY+ G IE S
Sbjct: 2016 PTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERS 2075
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDL 538
RI P + +C LVI +V AEDS A N G SS A L V+ + +
Sbjct: 2076 D--RIYWYWPE-----DNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLI 2128
Query: 539 SNNGSLHS--ANSTTNLAAIEPQPSPP 563
+ L A +A E + S P
Sbjct: 2129 TFTQELQDVVAKEKDTMATFECETSEP 2155
Score = 58.9 bits (141), Expect = 3e-08
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 16/147 (10%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG----VPE 1185
S L++ L + ++ A N+ G++ SL L+VV ++ + P I +L G V
Sbjct: 8856 SFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKA 8915
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETI--------PCTRERISMHQDTTGYACLLIQPAK 1237
G PV + V G+P P W K NET+ T+E +S + T L I A
Sbjct: 8916 GEPVHIPADVTGLPMPKIEWSK-NETVIEKPTDALQITKEEVSRSEAKTE---LSIPKAV 8971
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDIY 1264
+ D G YT++A N G V +++Y
Sbjct: 8972 REDKGTYTVTASNRLGSVFRNVHVEVY 8998
Score = 58.2 bits (139), Expect = 5e-08
Identities = 40/128 (31%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
K AP+ ++++ V G FTC+I P + WFK G++I + ++ C + R
Sbjct: 4333 KRAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYE-SDKCSI-RSSKY 4390
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
SL I T D G YT A+N G +SC+ L V T G + R + E
Sbjct: 4391 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV---------TVPGGEKKVRKLLPE 4441
Query: 1061 RDKEPLQE 1068
R EP +E
Sbjct: 4442 RKPEPKEE 4449
Score = 57.8 bits (138), Expect = 7e-08
Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F +RL+ V +GS V ++ GIP P V +++DG +I + ++ +EGD SL
Sbjct: 104 PNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDF-QISQEGD-LYSL 161
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ---SLPIRSRLTSAGQSHRGRSRVQER 1061
I +D G Y++ A N GR + + L+VQ +P + T + SR Q R
Sbjct: 162 LIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESR-QTR 220
Query: 1062 DKEPLQERF 1070
++ ++ F
Sbjct: 221 IEKKIEAHF 229
Score = 56.6 bits (135), Expect = 2e-07
Identities = 52/196 (26%), Positives = 80/196 (40%), Gaps = 19/196 (9%)
Query: 849 PRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSF 908
PRS P QG + + +P D R K T S + N E+++ F
Sbjct: 8821 PRSNGGSPIQGYIIEKRRHDKP---DFERVNKRLCP-------TTSFLVENLDEHQMYEF 8870
Query: 909 EQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKI 968
+ +NEI E P + IQ DE+P I R +V G PV +
Sbjct: 8871 RVKAVNEIG---ESEPSLPLNVVIQDDEVPP--TIKLRLSVRGDTIKVKAGEPVHIPADV 8925
Query: 969 VGIPVPKVYWFKDGKQISKRNEHCKMRRE----GDGTCSLHIESTTSDDDGNYTIMAANP 1024
G+P+PK+ W K+ I K + ++ +E + L I +D G YT+ A+N
Sbjct: 8926 TGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNR 8985
Query: 1025 QGRISCSGHLMVQSLP 1040
G + + H+ V P
Sbjct: 8986 LGSVFRNVHVEVYDRP 9001
Score = 56.6 bits (135), Expect = 2e-07
Identities = 105/539 (19%), Positives = 201/539 (37%), Gaps = 76/539 (14%)
Query: 74 ESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQ 133
+ + A+ P K+ E + + SP+ +K SP P SPT +K +P
Sbjct: 26154 QKARVTEKAVTSPPRVKSPEPRVK---SPEAVK-SPKRVKSPEPSHPKAVSPTETKPTPT 26209
Query: 134 EAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKNHKS-KLESQNKVM 192
E + Q+ + K+ A+ +E++ L S +R + +K K +N
Sbjct: 26210 E--KVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHF 26267
Query: 193 QENSSS-------FSDLSERRERSSVPIPIPADTRDNEVN--------HALEQQEAKRRE 237
Q + S+ ++L+E + V I + ++ N ++ ++ +K E
Sbjct: 26268 QFHYSADGTYELKINNLTESDQGEYV-CEISGEGGTSKTNLQFMGQAFKSIHEKVSKISE 26326
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPP 297
+++ + T + P + EP+ P L+ V + + G P
Sbjct: 26327 TKKSDQKTTESTVTRKTEPKA---PEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPR 26383
Query: 298 PQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIY 357
P W +GK + + + L I + D+G Y+C N G+ S+S ++
Sbjct: 26384 PTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLT 26443
Query: 358 IEGVSSSD---------SEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQP 408
I+ + ++ SE P K+ + + E+S S I + ++Q +A
Sbjct: 26444 IKAIKDTEAQKVSTQKTSEITPQKKAVVQ----EEISQKALRSEEIKMSEAKSQEKLALK 26499
Query: 409 RVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ----------------NLSASEGQLV 452
A+ + I TK Q +S +EGQ +
Sbjct: 26500 EEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRL 26559
Query: 453 VFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGC 512
V + + GA V+W G + +S ++R ++ ++ TL I + D G
Sbjct: 26560 VLKANIAGATD--VKWVLNGVELTNSEEYRY------GVSGSDQ--TLTIKQASHRDEGI 26609
Query: 513 FTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL---------AAIEPQPSP 562
TC + K G V Q + +++LS+ + S + N+ I +PSP
Sbjct: 26610 LTCISKTKEGIVK--CQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP 26666
Score = 55.8 bits (133), Expect = 3e-07
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 48/323 (14%)
Query: 59 DLPDLSAFLSQ---EELDESVN-LARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFE 114
+L D AF+SQ + ++E N L I+ +P + E + K P + + ++S
Sbjct: 26632 ELSDAPAFISQPRSQNINEGQNVLFTCEISGEP---SPEIEWFKNNLPISISSNVSISRS 26688
Query: 115 PNFCQDNPRSPTSSKESPQEAKRPQY---CSETQS-----------KKVFLNKAADFIEE 160
N R+ + S K + CS T S ++V L + D
Sbjct: 26689 RNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGD---- 26744
Query: 161 LSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTR 220
+SL S SS+ ++ A K S +SSS S ++E + S
Sbjct: 26745 -TSLQGSFSSQSVQMSASKQEAS-------FSSFSSSSASSMTEMKFASMSA-------- 26788
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV 280
++ + E ++ T SS S + G PP+ +
Sbjct: 26789 -----QSMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISI 26843
Query: 281 PEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD--IHIVQAGNLHSLTIAEAFEEDTGR 338
EG + + C G P P+V W C G+++ + HI +L +L I + ++D G
Sbjct: 26844 DEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGL 26903
Query: 339 YSCFASNIYGTDSTSAEIYIEGV 361
Y+ N +G+DS + I+I +
Sbjct: 26904 YTLSLGNEFGSDSATVNIHIRSI 26926
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 2/95 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENS--PDIHIVQAGNLH 324
Q P FTQ L+S V EG+ + + G P P+V W+ +G+ + S P + I +
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
LTI + ++GRYS A+N G +++AE+ ++
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVK 98
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/149 (28%), Positives = 69/149 (46%), Gaps = 10/149 (6%)
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
HK ++ET ++D + ++ N+ G++ + VV KE + PV+ KL
Sbjct: 11654 HKGSIKET---HYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKL 11710
Query: 1179 QNC-GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRE---RISMHQDTTGYACLLIQ 1234
V G +RLE V G P P W KD + TR +I D++ ++ +
Sbjct: 11711 SGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFS---LT 11767
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
AK+SD G Y ++A N AG A +++
Sbjct: 11768 KAKRSDGGKYVVTATNTAGSFVAYATVNV 11796
Score = 55.1 bits (131), Expect = 4e-07
Identities = 64/280 (22%), Positives = 107/280 (38%), Gaps = 33/280 (11%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T+ +++ EVPE +C V P + W G E+E S IV G LH L I
Sbjct: 2839 TKTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNT 2897
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
ED+ Y+ + G D SA + + + + D N EE + I V+ +
Sbjct: 2898 STEDSAEYTF----VCGNDQVSATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGISY 2953
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQG-------LDGKPIIAAPV-------- 436
+ V Q R + + N G + GK A +
Sbjct: 2954 KWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYTFVAGKATSTATLYVEARHIE 3013
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
F K ++++ E + +FEC V P V+W ++ ++ + +I ++K
Sbjct: 3014 FRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEK--------Y 3064
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ L+I D+G +T A T A+L V G +
Sbjct: 3065 VHRLLIPSTRMSDAGKYTVVAGGNVST----AKLFVEGRD 3100
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/92 (35%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 1172 PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACL 1231
P ++ L+N V EG V LEC + G P P W +++ I + + Q +G A L
Sbjct: 897 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQ--SGIARL 954
Query: 1232 LIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+I+ A D+G +T SA NEAG VS + L +
Sbjct: 955 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV 986
Score = 54.3 bits (129), Expect = 8e-07
Identities = 78/382 (20%), Positives = 141/382 (36%), Gaps = 55/382 (14%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS--PDFRILQKKPRSM 491
AP FT+ LQ++ EG FE + G P P+V W+R+G +I S P +I R+
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA- 63
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN------NGSLH 545
L I V +SG ++ A+N G +S A+L V+ N + ++
Sbjct: 64 -------KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVR 116
Query: 546 SANSTTNLAAIEPQPSPP---HSEPPSVEQ------PPKPKLEGVLVNHNEPRSSSRIGL 596
+ + P+P + + ++ + L +L+ P S +
Sbjct: 117 QGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSV 176
Query: 597 RVHFNLPEDDKGSE----------------ASSEAGVVTTRQTRPD-SFQERFNGQATKT 639
++ +E S A + +RQTR + + F+ ++ T
Sbjct: 177 NATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT 236
Query: 640 PE--------PSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFPFS 691
E P K PP + KPK S + + L + Q PS + P
Sbjct: 237 VEMVIDGAAGQQLPHKTPPRIPPKPKSRSPTPPSIAAKAQLARQQ----SPSPIRHSPSP 292
Query: 692 MTVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLSSTP 751
+ + + P V + S + +S S+ P + +T AT P P +
Sbjct: 293 VRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVAT-GPEVPPPWKQEGYV 351
Query: 752 QTIQRTVSKESLLVSHPSVQTK 773
+ +E+ L + ++T+
Sbjct: 352 ASSSEAEMRETTLTTSTQIRTE 373
Score = 53.1 bits (126), Expect = 2e-06
Identities = 68/307 (22%), Positives = 117/307 (38%), Gaps = 39/307 (12%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H L ++ K +A + A T ++L+ +EP P FT+ L + V EG
Sbjct: 5753 HTLTLRDVKLEDAGEVQLTAKDFKTH-----ANLFVKEP---PVEFTKPLEDQTVEEGAT 5804
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+C V +V+W+ G E+ S IV G + L I + ED Y+C A +
Sbjct: 5805 AVLEC-EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 5863
Query: 346 I--------------YGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS 391
+ T ++ + ++ + E ++ + E+
Sbjct: 5864 FKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFECELSRENAKVKWFKDGAEIKKGKKYD 5923
Query: 392 AVIPPAVPQAQHLVAQPRVATIQ---QCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+ AV + LV + + C+ T G+ + VFTK L N+ SE
Sbjct: 5924 IISKGAV---RILVINKCLLDDEAEYSCEVRTARTSGM-LTVLEEEAVFTKNLANIEVSE 5979
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C V P +V WY+ I ++ + IL + + + LVI E
Sbjct: 5980 TDTIKLVCEV-SKPGAEVIWYKGDEEIIETGRYEILTEGRKRI--------LVIQNAHLE 6030
Query: 509 DSGCFTC 515
D+G + C
Sbjct: 6031 DAGNYNC 6037
Score = 53.1 bits (126), Expect = 2e-06
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 4/128 (3%)
Query: 229 EQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREV---PEGTR 285
E E +R E A AA + P S + ++ + +PPR ++ R+V G
Sbjct: 19251 ELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDV-EPPRVMMDVKFRDVIVVKAGEV 19309
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
++++ + G P P + W +G E+E I+ N LT+ + DTG+Y N
Sbjct: 19310 LKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKN 19369
Query: 346 IYGTDSTS 353
+ GT S +
Sbjct: 19370 VAGTRSVA 19377
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVG 294
R + E E+ + + +P S + P+ Q P F ++LR+ V + L C V G
Sbjct: 24401 RVKCENLGGESEWSEISEPITPKS---DVPI-QAPHFKEELRNLNVRYQSNATLVCKVTG 24456
Query: 295 IPPPQVRWYCEGKELENSPDIHIVQ--AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P V+WY +GKE+ + +Q G H L IA ++D Y A+N G+ S
Sbjct: 24457 HPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSG 24516
Query: 353 SAEIYIE 359
+A + +E
Sbjct: 24517 TASLEVE 24523
Score = 52.4 bits (124), Expect = 3e-06
Identities = 71/307 (23%), Positives = 109/307 (35%), Gaps = 63/307 (20%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K LK+ VTE FT ++ V V W K+G + + NE + +G SL I++
Sbjct: 2665 KTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGV-VLESNEKYAISVKGT-IYSLRIKN 2722
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
D+ Y GR+ S L V+++ I
Sbjct: 2723 CAIVDESVYGFRL----GRLGASARLHVETVKI--------------------------- 2751
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ P D+ A E + VS P + W + P H+ LV E V
Sbjct: 2752 -------IKKPKDVTALENATVAFEVSVSHDTVP-VKWFHKSVEIKPSDKHR-LVSERKV 2802
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
H L++ ++ DAG Y + GQ +L V + K ++N VPE
Sbjct: 2803 HKLMLQNISPSDAGEYTAV----VGQLECKAKLFVETLHITKT------MKNIEVPETKT 2852
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQPAKKSDAGWY 1244
EC V P + K E + +I +HQ L+I D+ Y
Sbjct: 2853 ASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLHQ-------LIIMNTSTEDSAEY 2905
Query: 1245 TLSAKNE 1251
T N+
Sbjct: 2906 TFVCGND 2912
Score = 52.4 bits (124), Expect = 3e-06
Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 11/138 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRF---TQKLRSREVPEGTRVQLDCIVVGIPPPQVRW 302
A G++ P P + ++ L +PP R + + G ++L I+ G+P P+V W
Sbjct: 10697 AAGESDPAHVPEPVLVKDRL-EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTW 10755
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
E ++ I + G+ L I A ED G YS N G+ + S ++ +
Sbjct: 10756 KKEDRDAPTKARIDVTPVGS--KLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLV---- 10809
Query: 363 SSDSEGDPNKEEMNRIQK 380
D G P E++ I+K
Sbjct: 10810 -LDKPGPPRDLEVSEIRK 10826
Score = 52.4 bits (124), Expect = 3e-06
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVILEKLQN 1180
+V E+ V + ++ L+ ++ A N+ G++ L + V+AK++ P +
Sbjct: 17764 IVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNT 17823
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSD 1240
+ G +++E VIG P P W KD E + T R+++ + T L I+ K D
Sbjct: 17824 YSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQT-TRVNVEETATS-TVLHIKEGNKDD 17881
Query: 1241 AGWYTLSAKNEAG 1253
G YT++A N AG
Sbjct: 17882 FGKYTVTATNSAG 17894
Score = 52.0 bits (123), Expect = 4e-06
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP K +++++ G+ C++ G P P ++WYR G ++Q + M+
Sbjct: 24035 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGK--------ELIQSRKYKMSS 24086
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
TL + ED G +TC A+N+ G V + ++L
Sbjct: 24087 DGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKL 24123
Score = 52.0 bits (123), Expect = 4e-06
Identities = 35/102 (34%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRS 490
I AP F + L+NL+ C+V G P P V+WYR+G +I D +RI + K
Sbjct: 24428 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFK--- 24484
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L+IA V +D+ + A+N+ G+VS A L V
Sbjct: 24485 ----GGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24522
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/135 (30%), Positives = 66/135 (48%), Gaps = 14/135 (10%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP-------EGHP 1188
LT+ T++ A N+ G+ + S E++VVA++ AP + K G+P E
Sbjct: 13448 LTEGKEYTFRVSAENENGEGTPS-EITVVARDDVVAPDLDLK----GLPDLCYLAKENSN 13502
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
RL+ + G P P WKK + + T R+S+ L++ +KSDAG YT++
Sbjct: 13503 FRLKIPIKGKPAPSVSWKKGEDPL-ATDTRVSVESSAVN-TTLIVYDCQKSDAGKYTITL 13560
Query: 1249 KNEAGIVSCTARLDI 1263
KN AG T + +
Sbjct: 13561 KNVAGTKEGTISIKV 13575
Score = 51.2 bits (121), Expect = 6e-06
Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 18/187 (9%)
Query: 215 IPAD--TRDNEVNHALEQQEAKRREAEQAAS------EAAGGDTTPGSSPSSLYYEEPLG 266
+P D R N H + Q+E E+ A + +P S PS
Sbjct: 12734 LPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAEN 12793
Query: 267 QPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PPR + + V GT V LD V G P P V W +G L+ + I + NL
Sbjct: 12794 VPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL 12853
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
+L + +D+G Y+ A N G+ S + ++ + D G P ++N++
Sbjct: 12854 CTLELFSVNRKDSGDYTITAENSSGSKSATIKLKV-----LDKPGPPASVKINKMYSDRA 12908
Query: 384 VSS--PP 388
+ S PP
Sbjct: 12909 MLSWEPP 12915
Score = 51.2 bits (121), Expect = 6e-06
Identities = 27/87 (31%), Positives = 41/87 (47%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
T ++ VP G V+L + G PPP W+ G +L S + + + LTI E
Sbjct: 23245 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET 23304
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYI 358
DTG Y+ N+ GT S + ++ I
Sbjct: 23305 TIRDTGEYTLELKNVTGTTSETIKVII 23331
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 8/89 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
L+ G V + V G P P V W ++GTL++ + + MA +CTL +
Sbjct: 12808 LTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK--------MAMQRNLCTLELF 12859
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
V +DSG +T TA N G+ S+ +L V
Sbjct: 12860 SVNRKDSGDYTITAENSSGSKSATIKLKV 12888
Score = 50.1 bits (118), Expect = 1e-05
Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 3/123 (2%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVR 1190
+I LTQ + ++ +A N+ G++ SL + +VAK++ P + + V G ++
Sbjct: 16692 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 16751
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E + G P P W KD + T RI++ D+ L I+ K D G Y ++ N
Sbjct: 16752 IEVPISGRPKPTITWTKDGLPLKQT-TRINV-TDSLDLTTLSIKETHKDDGGQYGITVAN 16809
Query: 1251 EAG 1253
G
Sbjct: 16810 VVG 16812
Score = 49.7 bits (117), Expect = 2e-05
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 14/144 (9%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV-----ILEKLQNCGVPEGHPVR 1190
LT+ + T++ +A N G+++ V+ KE P I +KL G ++
Sbjct: 14530 LTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--GDNIK 14587
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+E V+G P P WKK ++ + T +R++ T L I +SD+G Y L+A+N
Sbjct: 14588 VEIPVLGRPKPTVTWKKGDQILKQT-QRVNFETTATS-TILNINECVRSDSGPYPLTARN 14645
Query: 1251 EAGIVSCTARLDIYAQWHHQIPPP 1274
G V D+ H IP P
Sbjct: 14646 IVGEVG-----DVITIQVHDIPGP 14664
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/295 (24%), Positives = 113/295 (38%), Gaps = 55/295 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDD 1013
+V EG V K+ V V W KDG+++ + H + ++ L IE T +D
Sbjct: 2320 KVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRVHIVIDKQSH---MLLIEDMTKED 2375
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
GNY+ P +S SG + V S+ + + L
Sbjct: 2376 AGNYSFTI--PALGLSTSGRVSVYSVDVITPLK--------------------------- 2406
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
D+ EG L+CKVS + W LN + + PD + +V+ T L+I
Sbjct: 2407 -------DVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGT-KQRLVI 2458
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ D G YK I G+ + LSV +++K I+ L++ E V E
Sbjct: 2459 NRTHASDEGPYKLI----VGRVETNCNLSV--EKIK----IIRGLRDLTCTETQNVVFEV 2508
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+ V + KD E P ++ +I H L + K D G YT A
Sbjct: 2509 ELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYK---LTVLNMMKDDEGKYTFYA 2560
Score = 49.3 bits (116), Expect = 2e-05
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 54/300 (18%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K +K+ V E +F C++ VP + W K+G +I + +E K+ +G L I +
Sbjct: 2840 KTMKNIEVPETKTASFECEVSHFNVPSM-WLKNGVEI-EMSEKFKIVVQGK-LHQLIIMN 2896
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQE 1068
T+++D YT + N Q S L V + I S L +E+D +
Sbjct: 2897 TSTEDSAEYTFVCGNDQ----VSATLTVTPIMITSMLKDI--------NAEEKDTITFEV 2944
Query: 1069 RFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
V +EG WL NG + +M ++
Sbjct: 2945 -------------TVNYEG--------------ISYKWLKNGVEIKSTDKCQMRTKKL-T 2976
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
HSL I + DA Y +A G+ + + L V A+ ++ + +++ V E
Sbjct: 2977 HSLNIRNVHFGDAADYTFVA----GKATSTATLYVEARHIE----FRKHIKDIKVLEKKR 3028
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
EC V P W KD++ + T +RI + ++ + LLI + SDAG YT+ A
Sbjct: 3029 AMFECEV-SEPDITVQWMKDDQELQIT-DRIKIQKEKYVHR-LLIPSTRMSDAGKYTVVA 3085
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/229 (27%), Positives = 91/229 (39%), Gaps = 43/229 (18%)
Query: 844 NAMGLPRSAPSMPSQGLAKKNTKSPQPVND--DNIRETK----NAVIRDLGKKIT----- 892
N+ GL S+PS PS+ + P D D RET N +RD G KI
Sbjct: 21338 NSAGL--SSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIE 21395
Query: 893 ------------FSDVRPNQQEYKISSFEQRLMNEIEFRL-ERTPVDESDDEIQHDEI-- 937
F+DV ++ +Y ++ + EFR+ R V Q I
Sbjct: 21396 KRQGNERWVRCNFTDV--SECQYTVTGLSPG--DRYEFRIIARNAVGTISPPSQSSGIIM 21451
Query: 938 PTGKCIAPIFDKRLKHFR---VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKM 994
+ + PI + ++F + G + + G PVP+V WFKDG +I KR M
Sbjct: 21452 TRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKR-----M 21506
Query: 995 RREGD---GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
E G+ SL + T D G YT+ A N G + VQ P
Sbjct: 21507 NMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTP 21555
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/126 (23%), Positives = 57/126 (45%), Gaps = 8/126 (6%)
Query: 1143 TYKCIATNKTGQNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
+++ A N G + +S ++ + E+ + + + + G +RL V G
Sbjct: 22917 SFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGR 22976
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
PPPV W K + ++ T Y+ L++ + DAG YT+ A+N++G S T
Sbjct: 22977 PPPVITWSKQGIDLASR----AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSAT 23032
Query: 1259 ARLDIY 1264
+ +Y
Sbjct: 23033 VLVKVY 23038
Score = 48.9 bits (115), Expect = 3e-05
Identities = 42/185 (22%), Positives = 74/185 (40%), Gaps = 13/185 (7%)
Query: 187 SQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRR---------- 236
+ KV +E+ S R E + + + + + E+ K +
Sbjct: 1940 THEKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKEL 1999
Query: 237 -EAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
E E+ A G T P P + P + P+ ++++S+ V +G+ VVG
Sbjct: 2000 TEEEKKALAEEGKITIPTFKPDKIELS-PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGK 2058
Query: 296 PPPQVRWYCEGKELENSPDIH-IVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P+ WY G ++E S I+ N+ L I + ED+ A NI G S+ A
Sbjct: 2059 PDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHA 2118
Query: 355 EIYIE 359
+ ++
Sbjct: 2119 FLLVQ 2123
Score = 48.9 bits (115), Expect = 3e-05
Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E R E A AAG + P S ++ + + PPR + + ++ V G ++
Sbjct: 16008 EDHRYEFRVIARNAAGVFSEPSESTGAITARDEV-DPPRISMDPKYKDTIVVHAGESFKV 16066
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
D + G P P ++W +EL N+ + I SL++ +A D+G Y A N+ G
Sbjct: 16067 DADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG 16126
Query: 349 TDSTSAEIYI 358
S + + +
Sbjct: 16127 ERSVTVNVKV 16136
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/94 (30%), Positives = 44/94 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP E+L+N V L C+V G P P+ W + + I + + + GY
Sbjct: 24429 QAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYH 24488
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L+I DA Y + A N+ G VS TA L++
Sbjct: 24489 QLIIASVTDDDATVYQVRATNQGGSVSGTASLEV 24522
Score = 48.5 bits (114), Expect = 4e-05
Identities = 101/438 (23%), Positives = 156/438 (35%), Gaps = 100/438 (22%)
Query: 872 NDDNIRETKNAVIRDLGK--KITFSDVRPNQQEYKISSFEQRLMNEIEFRLE-RTPVDES 928
ND + T++ ++D GK ITF D+ I Q + + E + V E
Sbjct: 5467 NDQRLHTTRSVSMQDEGKTHSITFKDL-------SIDDTSQIRVEAMGMSSEAKLTVLEG 5519
Query: 929 DDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKR 988
D P F +L+ + E V C+I P V WFKDGK+I K
Sbjct: 5520 D---------------PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEI-KP 5562
Query: 989 NEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ--GRISCSGHLMVQSLPIRSRLT 1046
+++ ++ +G L ++ D G YT + G++ + P+ S
Sbjct: 5563 SKNAVIKADGKKR-MLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKLVRPLHSVEV 5621
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRL-------CRLD------ 1093
++ R + + E D + LQ P + EG++ CRLD
Sbjct: 5622 METETARFETEISEDDIH-ANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVD 5680
Query: 1094 ---------------CKVSGLPPP-----------------------ELTWLLNGQPVLP 1115
+V GL P + W L G+ + P
Sbjct: 5681 FQAANVKSSAHLRVKPRVIGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEP 5740
Query: 1116 DASHKMLVRETG-VHSLLIDPLTQRDAGTYKCIATN-KTGQNSFSLELSVVAKEVKKAPV 1173
S K++ R G VH+L + + DAG + A + KT N F VK+ PV
Sbjct: 5741 --SDKVVPRSEGKVHTLTLRDVKLEDAGEVQLTAKDFKTHANLF----------VKEPPV 5788
Query: 1174 ILEK-LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL 1232
K L++ V EG LEC V V ++K E + + I L+
Sbjct: 5789 EFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRK---LV 5845
Query: 1233 IQPAKKSDAGWYTLSAKN 1250
I D YT AK+
Sbjct: 5846 IHDCTPEDIKTYTCDAKD 5863
Score = 48.5 bits (114), Expect = 4e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT KL+ E V L C + P V+W+ +GKE++ S + I G L +
Sbjct: 5521 PYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGKKRMLIL 5579
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+A + D G+Y+C GTD TS ++ IE
Sbjct: 5580 KKALKSDIGQYTCDC----GTDKTSGKLDIE 5606
Score = 48.5 bits (114), Expect = 4e-05
Identities = 54/231 (23%), Positives = 91/231 (39%), Gaps = 22/231 (9%)
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG- 360
W +G+ L +PD I + G +HSL + + TG A+N+ + + + G
Sbjct: 5642 WKLKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGL 5701
Query: 361 ------VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQ 414
V+ + E E++ P E VP+++ V + ++
Sbjct: 5702 LRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVK 5761
Query: 415 QCQSPTNYLQGLDGKP-----IIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ L D K + PV FTK L++ + EG V EC V + KV+W
Sbjct: 5762 LEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEV-SRENAKVKW 5820
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASN 519
++ GT IL+ K + + LVI + ED +TC A +
Sbjct: 5821 FKNGT--------EILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 5863
Score = 48.5 bits (114), Expect = 4e-05
Identities = 38/137 (27%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLEL--SVVAKEVKKAPVI---LEKLQNCGVPEG 1186
+I LTQ ++ A N G S E+ + + PVI LE + G
Sbjct: 20331 IISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAG 20390
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
V+L + G P P W KD++ + + ++TT A +LI+ A + ++G Y L
Sbjct: 20391 TSVKLRAGISGKPAPTIEWYKDDKELQTNA--LVCVENTTDLASILIKDADRLNSGCYEL 20448
Query: 1247 SAKNEAGIVSCTARLDI 1263
+N G S T R+ I
Sbjct: 20449 KLRNAMGSASATIRVQI 20465
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ G+ V V G P PK+EW + T+IE D LQ ++ E L I
Sbjct: 8911 IKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD--ALQITKEEVSRSEAKTELSIP 8968
Query: 504 EVFAEDSGCFTCTASNKYGTV 524
+ ED G +T TASN+ G+V
Sbjct: 8969 KAVREDKGTYTVTASNRLGSV 8989
Score = 47.8 bits (112), Expect = 7e-05
Identities = 61/274 (22%), Positives = 105/274 (38%), Gaps = 66/274 (24%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVY----------------WFKDGKQISKRNEHCKMRREGD 999
+ EG+ V F ++ I VP+ Y W+ + ++ ++ R G
Sbjct: 2215 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDVELKSNGKYTITSRRGR 2274
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+L ++ T +D G Y+ + + +C L ++ PI
Sbjct: 2275 Q--NLTVKDVTKEDQGEYSFVIDGK--KTTCK--LKMKPRPIA----------------- 2311
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP-DAS 1118
LQ D EG + +L+ KVS L E W+ +GQ V P D
Sbjct: 2312 ---------------ILQGLSDQKVCEGDIVQLEVKVS-LESVEGVWMKDGQEVQPSDRV 2355
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
H ++ +++ H LLI+ +T+ DAG Y +L LS + + ++ L
Sbjct: 2356 HIVIDKQS--HMLLIEDMTKEDAGNYSFTIP--------ALGLSTSGRVSVYSVDVITPL 2405
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
++ V EG LEC+V W ++E I
Sbjct: 2406 KDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI 2439
Score = 47.8 bits (112), Expect = 7e-05
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 34/286 (11%)
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
FT+ L + EV E ++L C V P +V WY +E+ + I+ G L I
Sbjct: 5968 FTKNLANIEVSETDTIKLVC-EVSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQN 6026
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
A ED G Y+C + T ++ + +++ + P E+ +K V S
Sbjct: 6027 AHLEDAGNYNCRLPS----SRTDGKVKVHELAA-EFISKPQNLEILEGEKAEFVCSISKE 6081
Query: 391 SAVIP--------------PAVPQAQHLVAQPRVATIQQCQS---PTNYLQGLDGKPIIA 433
S + + + V + AT+Q + + +I
Sbjct: 6082 SFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTVIE 6141
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
L++ E Q VVF C V K +W+R I DS + ILQK
Sbjct: 6142 KLRIVVPLKDTRVKEQQEVVFNCEVN-TEGAKAKWFRNEEAIFDSSKYIILQK------- 6193
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDL 538
+ + TL I + +D + + +N G V S A L V EDL
Sbjct: 6194 -DLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVE-EEDL 6237
Score = 47.4 bits (111), Expect = 9e-05
Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 6/126 (4%)
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV--AKEVKKAPVILEKLQNCGVPEGH 1187
SL++ L + ++ A N G S E V AKE P IL Q + G
Sbjct: 12360 SLVVTGLKEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQLLPPKILMPEQ-ITIKAGK 12417
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLS 1247
+R+E V G P P WKK + + T +++H+ + + L+I+ + D+G+Y+L+
Sbjct: 12418 KLRIEAHVYGKPHPTCKWKKGEDEV-VTSSHLAVHKADSS-SILIIKDVTRKDSGYYSLT 12475
Query: 1248 AKNEAG 1253
A+N +G
Sbjct: 12476 AENSSG 12481
Score = 47.4 bits (111), Expect = 9e-05
Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 9/146 (6%)
Query: 900 QQEYKISSFEQRLMNEIEFR-LERTPVDESDDEIQHDEIPT-GKCIAPIFDKRLKH---F 954
Q+EY + E++ + +FR + RT V+ S D + + + P D +
Sbjct: 12751 QEEYTATGLEEKA--QYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLL 12808
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
V G+ V + G P+P V W KDG + K E KM + + C+L + S D
Sbjct: 12809 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLL-KPAEGIKMAMQRN-LCTLELFSVNRKDS 12866
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLP 1040
G+YTI A N G S + L V P
Sbjct: 12867 GDYTITAENSSGSKSATIKLKVLDKP 12892
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/137 (25%), Positives = 50/137 (36%), Gaps = 14/137 (10%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E L++ E R A + A D P + Y EP+ V E
Sbjct: 1762 EGRKGLQRIEELERMAHEGALTGVTTDQKEKQKPDIVLYPEPV-------------RVLE 1808
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G + C V G P P+V WY G+ + S + G +H L I + DTG
Sbjct: 1809 GETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDG-IHYLDIVDCKSYDTGEVKVT 1867
Query: 343 ASNIYGTDSTSAEIYIE 359
A N G ++ I+
Sbjct: 1868 AENPEGVIEHKVKLEIQ 1884
Score = 46.6 bits (109), Expect = 2e-04
Identities = 39/134 (29%), Positives = 55/134 (41%), Gaps = 14/134 (10%)
Query: 226 HALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTR 285
H LE +E + Q ++ SS + L P FT KL + E
Sbjct: 5131 HKLEMKEVTLDDISQIKAQV--------KELSSTAQLKVLEADPYFTVKLHDKTAVEKDE 5182
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+ L C V P V+W+ +G+E+ SP I G L I +A +D G Y C
Sbjct: 5183 ITLKCEVSKDVP--VKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDC-- 5238
Query: 346 IYGTDSTSAEIYIE 359
GTD T A + +E
Sbjct: 5239 --GTDKTKANVTVE 5250
Score = 46.6 bits (109), Expect = 2e-04
Identities = 76/301 (25%), Positives = 114/301 (37%), Gaps = 58/301 (19%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLH 1005
F K L+ V EG+ C+ V KV WFK+G +I K K DG L
Sbjct: 5790 FTKPLEDQTVEEGATAVLECE-VSRENAKVKWFKNGTEILKSK---KYEIVADGRVRKLV 5845
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
I T +D YT A + + SC+ +++ P
Sbjct: 5846 IHDCTPEDIKTYTCDAKD--FKTSCNLNVV-----------------------------P 5874
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
F RP D+ E + R +C++S ++ W +G + + ++ +
Sbjct: 5875 PHVEFLRP-----LTDLQVREKEMARFECELS-RENAKVKWFKDGAEIKKGKKYD-IISK 5927
Query: 1126 TGVHSLLIDPLTQRDAGTYKC-IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
V L+I+ D Y C + T +T S L+V+ +E V + L N V
Sbjct: 5928 GAVRILVINKCLLDDEAEYSCEVRTART-----SGMLTVLEEEA----VFTKNLANIEVS 5978
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG-YACLLIQPAKKSDAGW 1243
E ++L C V V ++K D E I R I T G L+IQ A DAG
Sbjct: 5979 ETDTIKLVCEVSKPGAEVIWYKGDEEIIETGRYEIL----TEGRKRILVIQNAHLEDAGN 6034
Query: 1244 Y 1244
Y
Sbjct: 6035 Y 6035
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/97 (36%), Positives = 43/97 (44%), Gaps = 8/97 (8%)
Query: 951 LKHF-RVTEGSPVTFTCKIVGIPVPKVYWFK------DGKQISKRNEHCKMRREGDGTCS 1003
LK F V EG+ V KI G+P P + WFK D K+ + H + D TC+
Sbjct: 9625 LKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN-KLVVDDTCT 9683
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L I + D G YTI A N G S L V P
Sbjct: 9684 LVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRP 9720
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ EG V ++KG P P + W++ D+ + +L + ++ CTLVI
Sbjct: 9629 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKE-PVLYDTHVNKLVVDDTCTLVIP 9687
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ D+G +T TA N GT S +L+V G
Sbjct: 9688 QSRRSDTGLYTITAVNNLGTASKEMRLNVLG 9718
Score = 46.6 bits (109), Expect = 2e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I LT + ++ A N+ G++ L + V+A++++ P + V +++
Sbjct: 18858 ISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKI 18917
Query: 1192 ECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
+ G P W+KD +T+ TR +S + T L I+ A K D G Y L N
Sbjct: 18918 DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS---LSIKEASKEDVGTYELCVSN 18974
Query: 1251 EAGIVS 1256
AG ++
Sbjct: 18975 SAGSIT 18980
Score = 46.2 bits (108), Expect = 2e-04
Identities = 29/97 (29%), Positives = 45/97 (46%)
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA 1229
+AP + LQ+ V EG E + G P P W +D + I + + G A
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRA 63
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
L I K+++G Y+L A N +G + TA L + A+
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE 100
Score = 46.2 bits (108), Expect = 2e-04
Identities = 26/98 (26%), Positives = 39/98 (39%), Gaps = 1/98 (1%)
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L P M +EG R C G P P +TWL GQ + A H++ + + I
Sbjct: 26067 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKY-KSTFEISS 26125
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV 1173
+ D G Y + N G+ L++ V + V
Sbjct: 26126 VQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAV 26163
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/90 (28%), Positives = 42/90 (46%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P +K+ EV G + C + P + +W+ G+E+ S I + + SL I
Sbjct: 4337 PVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEI 4396
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
D G Y+C ASN YG+ S +A + +
Sbjct: 4397 LRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGR 338
V GT V+ I+ G+P P +W +G E++ + + + V+ N S LTI DTG
Sbjct: 11025 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIK-TDEHYTVETDNFSSVLTIKNCLRRDTGE 11083
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y SN G+ + + + +
Sbjct: 11084 YQITVSNAAGSKTVAVHLTV 11103
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/125 (31%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P Q L ++V EG VQL+ + V + + W +G+E++ S +HIV H L
Sbjct: 2308 RPIAILQGLSDQKVCEGDIVQLE-VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHML 2366
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I + +ED G YS F G STS + + V D N E + +VS
Sbjct: 2367 LIEDMTKEDAGNYS-FTIPALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSV 2424
Query: 387 PPTTS 391
P TS
Sbjct: 2425 PDVTS 2429
Score = 45.4 bits (106), Expect = 4e-04
Identities = 60/245 (24%), Positives = 86/245 (35%), Gaps = 15/245 (6%)
Query: 808 QPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKS 867
+P P P P ++ P P P +P AP + A+ T
Sbjct: 4477 KPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIK 4536
Query: 868 PQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYK--ISSFEQRLMNEIEFRLERTPV 925
P PV + + +GKK + + K I ++ + IE R
Sbjct: 4537 PPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAE-RRKLR 4595
Query: 926 DESDDEIQHDEIPTG---KCIAPIFDKRLKHFRVTE----GSPVTFTCKIVGIPVPKVYW 978
S E DE P K + F K +K +TE GS F C +V W
Sbjct: 4596 PGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFEC-LVSPSTAITTW 4654
Query: 979 FKDGKQISKRNEHCKMRREGDGTC-SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ 1037
KDG I + +H R DG LHI D G YT + + + L+V+
Sbjct: 4655 MKDGSNIRESPKH---RFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 4711
Query: 1038 SLPIR 1042
LP+R
Sbjct: 4712 ELPVR 4716
Score = 45.1 bits (105), Expect = 5e-04
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 3/122 (2%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL 1191
I L Q + +++ A N+ G + L + V+AK++ P V G +++
Sbjct: 15611 ITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKV 15670
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ IG P P W KDN +P + + T + L I+ A + D G Y + N
Sbjct: 15671 DVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNS 15728
Query: 1252 AG 1253
AG
Sbjct: 15729 AG 15730
Score = 45.1 bits (105), Expect = 5e-04
Identities = 22/80 (27%), Positives = 43/80 (53%)
Query: 277 SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT 336
S V G ++++ + G P P + W +G L+ + I++ + +L +L+I E ++D
Sbjct: 16741 SYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDG 16800
Query: 337 GRYSCFASNIYGTDSTSAEI 356
G+Y +N+ G + S EI
Sbjct: 16801 GQYGITVANVVGQKTASIEI 16820
Score = 45.1 bits (105), Expect = 5e-04
Identities = 35/130 (26%), Positives = 56/130 (43%), Gaps = 4/130 (3%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQL 288
E +R E A AAG + P S + ++ + + PR + + R+ V G +L
Sbjct: 17090 EDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEV-ELPRISMDPKFRDTIVVNAGETFRL 17148
Query: 289 DCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ V G P P + W KE+E S I L + +A D G+Y ASN+ G
Sbjct: 17149 EADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAG 17208
Query: 349 TDSTSAEIYI 358
+ S + +
Sbjct: 17209 SKSFPVNVKV 17218
Score = 44.7 bits (104), Expect = 6e-04
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 2/110 (1%)
Query: 931 EIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE 990
EI + + P D V EG ++ +PVP V W KDGK++ K ++
Sbjct: 7876 EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV-KASD 7934
Query: 991 HCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
M+ + + L + + D G YTI N G + S ++ V LP
Sbjct: 7935 RLTMKND-HISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLP 7983
Score = 44.7 bits (104), Expect = 6e-04
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 949 KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIES 1008
K ++ V G+ V F I G+PVP W DG +I K +EH + + + L I++
Sbjct: 11018 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI-KTDEHYTVETDNFSSV-LTIKN 11075
Query: 1009 TTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y I +N G + + HL V +P
Sbjct: 11076 CLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 11107
Score = 44.3 bits (103), Expect = 8e-04
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSLT 327
P F K S + EG + D VVG P P+ W+ +G+++ N +V + SL
Sbjct: 1411 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1470
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
I A D+G ++ A N G S S + +E V
Sbjct: 1471 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAV 1504
Score = 44.3 bits (103), Expect = 8e-04
Identities = 34/136 (25%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 1144 YKCIATNKTG-----QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
++ A N+TG + + S++ + + E AP I +++++ G +L C+++G
Sbjct: 24006 FRVFAENETGLSRPRRTAMSIKTKLTSGE---APGIRKEMKDVTTKLGEAAQLSCQIVGR 24062
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W + + + +R + M D + L + ++ D G YT A NE G V +
Sbjct: 24063 PLPDIKWYRFGKELIQSR-KYKMSSDGRTHT-LTVMTEEQEDEGVYTCIATNEVGEVETS 24120
Query: 1259 ARLDIYA--QWHHQIP 1272
++L + A Q+H P
Sbjct: 24121 SKLLLQATPQFHPGYP 24136
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/201 (21%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
V W + KE++ S I G ++ LT+ ++D G+Y+ +A G + TS ++ +
Sbjct: 2517 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYA----GENMTSGKLTVA 2572
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSP-------------PTTSAVIPPAVPQAQHL-V 405
G + S D E EV++P P T+ + + + L +
Sbjct: 2573 GGAISKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLII 2632
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
A ++ I + K + A K L+NL+ +E Q VF +
Sbjct: 2633 AATKLDDIGEYTYKV-ATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKG 2691
Query: 466 VEWYREGTLIEDSPDFRILQK 486
V+W + G ++E + + I K
Sbjct: 2692 VQWIKNGVVLESNEKYAISVK 2712
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/288 (20%), Positives = 109/288 (37%), Gaps = 39/288 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F L +V E + +C V P RW +E+ +++ G HS+
Sbjct: 5342 PLIFITPLSDVKVFEKDEAKFEC-EVSREPKTFRWLKGTQEITGDDRFELIKDGTKHSMV 5400
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG-----------VSSSDSEGDPNKEEMN 376
I A ED +Y A + + TS ++ IEG V++ + E E++
Sbjct: 5401 IKSAAFEDEAKYMFEAEDKH----TSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVELS 5456
Query: 377 ----RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPII 432
R++ TT +V + + + +I G+ + +
Sbjct: 5457 HDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKD--LSIDDTSQIRVEAMGMSSEAKL 5514
Query: 433 AA----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
P FT LQ+ + E V+ +C + A +P V+W+++G I+ S + I
Sbjct: 5515 TVLEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFKDGKEIKPSKNAVIKADGK 5573
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ M L++ + D G +TC GT + +L + E
Sbjct: 5574 KRM--------LILKKALKSDIGQYTCDC----GTDKTSGKLDIEDRE 5609
Score = 43.5 bits (101), Expect = 0.001
Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 31/258 (12%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V G DC + P V WY +GK+LE S + G +H+LT+ + E
Sbjct: 5705 LKDVTVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 5763
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIE--GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSA 392
D G A + T A ++++ V + D EE EVS
Sbjct: 5764 DAGEVQLTAKDF----KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVK 5819
Query: 393 VIPPAV----PQAQHLVAQPRV--ATIQQCQSPTNYLQGLDGKPI-------IAAP--VF 437
+ +VA RV I C D K + P F
Sbjct: 5820 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPPHVEF 5879
Query: 438 TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI 497
+ L +L E ++ FEC + + KV+W+++G I+ + I+ K +
Sbjct: 5880 LRPLTDLQVREKEMARFECEL-SRENAKVKWFKDGAEIKKGKKYDIISK--------GAV 5930
Query: 498 CTLVIAEVFAEDSGCFTC 515
LVI + +D ++C
Sbjct: 5931 RILVINKCLLDDEAEYSC 5948
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 5/121 (4%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +T+ ++ R GT V+L + G P P + WY + KEL+ + + + +L S+
Sbjct: 20378 PLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASIL 20434
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I +A ++G Y N G S SA I ++ + G P + + +K + P
Sbjct: 20435 IKDADRLNSGCYELKLRNAMG--SASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRP 20492
Query: 388 P 388
P
Sbjct: 20493 P 20493
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 5/78 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRDAGTYK 1145
G RL VSG PPP +TW G D + + ++ T +SLLI D + + DAG Y
Sbjct: 22964 GASLRLMVSVSGRPPPVITWSKQG----IDLASRAIIDTTESYSLLIVDKVNRYDAGKYT 23019
Query: 1146 CIATNKTGQNSFSLELSV 1163
A N++G+ S ++ + V
Sbjct: 23020 IEAENQSGKKSATVLVKV 23037
Score = 43.1 bits (100), Expect = 0.002
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVILEKLQ---NCGVPEGH 1187
+ LT+ A ++ IA N G S E S + ++ +AP I ++ + G
Sbjct: 14921 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 14980
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G PPP W KD + + T + I + +T L+ + + + D+G YTL
Sbjct: 14981 AFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN---LVNKDSTRRDSGAYTL 15037
Query: 1247 SAKNEAG 1253
+A N G
Sbjct: 15038 TATNPGG 15044
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 3/103 (2%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
A G +P S PS + P+ ++ ++ + G +L+ V G PPP + W
Sbjct: 14939 AAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEW 14998
Query: 303 YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+GKELE + + I A +L ++ D+G Y+ A+N
Sbjct: 14999 SKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATN 15041
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/211 (22%), Positives = 78/211 (36%), Gaps = 18/211 (8%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L+ V EGT+ L+C V V+WY ++++ + + G L I
Sbjct: 2405 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHAS 2464
Query: 335 DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPT----- 389
D G Y I G T+ + +E + D E + E+S
Sbjct: 2465 DEGPYKL----IVGRVETNCNLSVEKIKIIRGLRDLTCTETQNVVFEVELSHSGIDVLWN 2520
Query: 390 -TSAVIPPAVP---QAQHLVAQPRVAT-IQQCQSPTNYLQG---LDGKPIIAAPVFTKML 441
I P+ +A + + V ++ + + G GK +A +K L
Sbjct: 2521 FKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTVAGGAISKPL 2580
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
+ + +E Q VFEC V P K EW R+G
Sbjct: 2581 TDQTVAESQEAVFECEVAN-PDSKGEWLRDG 2610
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD- 1140
+V H G + R+ VSG PPP +TW +N + + +A+ + T + S ++ QR
Sbjct: 10037 IVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEAT----IETTAISSSMVIKNCQRSH 10092
Query: 1141 AGTYKCIATNKTGQNSFSLELSVV 1164
G Y +A N+ G+ ++ + V+
Sbjct: 10093 QGVYSLLAKNEAGERKKTIIVDVL 10116
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 8/125 (6%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVILEKLQNCG----VPEGHPVRLECRVIGM 1198
++ A N G+ L SV+AK++ P + E C V G +R+ RV G
Sbjct: 11380 FRIKAANIVGEGEPRELAESVIAKDILHPPEV-ELDVTCRDVITVRVGQTIRILARVKGR 11438
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCT 1258
P P W K+ + + +R+ + QD L I+ A ++D G Y +SAKN +G +
Sbjct: 11439 PEPDITWTKEGKVL-VREKRVDLIQDLPRVE-LQIKEAVRADHGKYIISAKNSSGHAQGS 11496
Query: 1259 ARLDI 1263
A +++
Sbjct: 11497 AIVNV 11501
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/90 (21%), Positives = 44/90 (48%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P + + G ++++ V+G P P + W +G+ L+ + +++ + L I
Sbjct: 17815 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHI 17874
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
E ++D G+Y+ A+N GT + + + +
Sbjct: 17875 KEGNKDDFGKYTVTATNSAGTATENLSVIV 17904
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 2/115 (1%)
Query: 248 GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVP--EGTRVQLDCIVVGIPPPQVRWYCE 305
G + P + SS+ +EP +P + ++ + G+ +D + G P P+V W E
Sbjct: 22128 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLE 22187
Query: 306 GKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
L+ + + I + +LT+ ++ D+GRY N G + S + + G
Sbjct: 22188 EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 22242
Score = 42.0 bits (97), Expect = 0.004
Identities = 42/181 (23%), Positives = 75/181 (41%), Gaps = 11/181 (6%)
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
TW+ +G + H+ + +ID + DAG Y C+ + + + +L V
Sbjct: 4653 TWMKDGSNIRESPKHRFIADGKDRKLHIID-VQLSDAGEYTCVLRLGNKEKTSTAKLVVE 4711
Query: 1165 AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
V+ + E++ V +G P+ L C + V W+KD + + RI
Sbjct: 4712 ELPVRFVKTLEEEVT---VVKGQPLYLSCELNKERDVV--WRKDGKIVVEKPGRIV--PG 4764
Query: 1225 TTGYA-CLLIQPAKKSDAGWYTLSAKNEAGI--VSCTARLDIYAQWHHQIPPPMSVRPSG 1281
G L I A +DAG YT++ +N + SC +++ W + V+P G
Sbjct: 4765 VIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKG 4824
Query: 1282 S 1282
+
Sbjct: 4825 T 4825
Score = 42.0 bits (97), Expect = 0.004
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 16/165 (9%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E + E A AG + P S ++ ++ P P L + G +
Sbjct: 13843 EGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLT---IKAGDTI 13899
Query: 287 QLDCI-VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ I ++G P P+ W GK++ S I LTI A +D G Y+ A+N
Sbjct: 13900 VLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATN 13959
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI--QKPNEVSSPP 388
+GT ++ + D G P E++ + +K +PP
Sbjct: 13960 PFGTKVEHVKVTV-----LDVPGPPGPVEISNVSAEKATLTWTPP 13999
Score = 42.0 bits (97), Expect = 0.004
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 2/84 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + G + ++G P P + W KDG+ + K+ + T
Sbjct: 17813 IQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPL-KQTTRVNVEETATSTV 17871
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
LHI+ DD G YT+ A N G
Sbjct: 17872 -LHIKEGNKDDFGKYTVTATNSAG 17894
Score = 41.6 bits (96), Expect = 0.005
Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V G V L+ V G P P WKKD + P +++M ++ L + + D+
Sbjct: 12810 VKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNL---CTLELFSVNRKDS 12866
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
G YT++A+N +G S T +L + + PP SV+
Sbjct: 12867 GDYTITAENSSGSKSATIKLKVL----DKPGPPASVK 12899
Score = 41.6 bits (96), Expect = 0.005
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
LD V G P P ++W +G + P KM + + + +L + + ++D+G Y A N
Sbjct: 12818 LDATVFGKPMPTVSWKKDGTLLKPAEGIKMAM-QRNLCTLELFSVNRKDSGDYTITAENS 12876
Query: 1152 TGQNSFSLELSVVAKEVKKAPVILEKL 1178
+G S +++L V+ K A V + K+
Sbjct: 12877 SGSKSATIKLKVLDKPGPPASVKINKM 12903
Score = 41.2 bits (95), Expect = 0.007
Identities = 74/335 (22%), Positives = 131/335 (39%), Gaps = 58/335 (17%)
Query: 922 RTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
R P +D +++ E+ A F + ++ + EG F C I P V W +D
Sbjct: 6038 RLPSSRTDGKVKVHEL------AAEFISKPQNLEILEGEKAEFVCSISKESFP-VQWKRD 6090
Query: 982 GKQISKRNEHCKMRREGDGTCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHL-MVQSL 1039
K + +++ + DG L ++ T D G Y +M G + HL +++ L
Sbjct: 6091 DKTLESGDKYDVI---ADGKKRVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKL 6143
Query: 1040 PIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGL 1099
I L +RV+E+ QE F +C+V+
Sbjct: 6144 RIVVPLKD--------TRVKEQ-----QEVVF---------------------NCEVN-T 6168
Query: 1100 PPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL 1159
+ W N + + D+S +++++ V++L I D Y TN G+N S
Sbjct: 6169 EGAKAKWFRNEEAIF-DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSA 6227
Query: 1160 ELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
+V +E + I+E L++ E V C+V + W K+ E +P R+
Sbjct: 6228 ANLIVEEEDLR---IVEPLKDIETMEKKSVTFWCKVNRL-NVTLKWTKNGEEVPFD-NRV 6282
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
S D + L I+ D G Y ++A + +
Sbjct: 6283 SYRVDKYKH-MLTIKDCGFPDEGEYIVTAGQDKSV 6316
Score = 41.2 bits (95), Expect = 0.007
Identities = 29/102 (28%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
+VVAK+ P I + + V EG + + +P P W KD + + + +R++M
Sbjct: 7880 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKAS-DRLTM 7938
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
D A L + + ++DAG YT++ +N+ G S TA +++
Sbjct: 7939 KNDHIS-AHLEVPKSVRADAGIYTITLENKLG--SATASINV 7977
Score = 40.8 bits (94), Expect = 0.009
Identities = 22/79 (27%), Positives = 36/79 (45%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V GT+++L V G P P++ W L+ I I ++TI ++ DTG Y
Sbjct: 7205 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 7264
Query: 340 SCFASNIYGTDSTSAEIYI 358
A N+ G + E+ +
Sbjct: 7265 IIEAVNVCGRATAVVEVNV 7283
Score = 40.8 bits (94), Expect = 0.009
Identities = 31/136 (22%), Positives = 59/136 (43%), Gaps = 5/136 (3%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
++ L + ++ A N G + S + + P ++ + V EG V +
Sbjct: 9581 VEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIV 9640
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERI----SMHQDTTGYACLLIQP-AKKSDAGWYTLS 1247
++ G+P P W K P +E + +++ C L+ P +++SD G YT++
Sbjct: 9641 AKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTIT 9700
Query: 1248 AKNEAGIVSCTARLDI 1263
A N G S RL++
Sbjct: 9701 AVNNLGTASKEMRLNV 9716
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +R+ V G PPP W + T+P + + + T + ++I+ ++S G
Sbjct: 10039 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLP----QEATIETTAISSSMVIKNCQRSHQG 10094
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
Y+L AKNEAG T +D+
Sbjct: 10095 VYSLLAKNEAGERKKTIIVDV 10115
Score = 40.8 bits (94), Expect = 0.009
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 9/126 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP-----PRFTQKLRSREVPEGTRV 286
E +R E A AAG + P S ++ + + P P++ + V G
Sbjct: 18172 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVI---VVHAGETF 18228
Query: 287 QLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
L+ + G P P V W +GKEL E + + I +L + + D G+Y SN
Sbjct: 18229 VLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSN 18288
Query: 346 IYGTDS 351
+ GT S
Sbjct: 18289 VGGTKS 18294
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 263 EPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGN 322
+P + P T +++RE ++++D G P V W +G+ L+ + +++ +
Sbjct: 18897 KPSVELPFHTFNVKARE-----QLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKT 18951
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ SL+I EA +ED G Y SN G+ + I +
Sbjct: 18952 VTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIV 18987
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 9/134 (6%)
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGHPVR 1190
L+ D ++ IA N G S + S ++ ++ P++ E + G +R
Sbjct: 21421 LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLR 21480
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMH-QDTTGYACLLIQPAKKSDAGWYTLSAK 1249
++ V G P P W KD I +R++M D G L ++ A + G YT+ AK
Sbjct: 21481 IKALVQGRPVPRVTWFKDGVEI---EKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAK 21537
Query: 1250 NEAGIVSCTARLDI 1263
N +G ++ +
Sbjct: 21538 NASGSAKAEIKVKV 21551
Score = 40.8 bits (94), Expect = 0.009
Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
+ G +++ +V G P P+V W+ +G E+E ++ I SL + +A + G Y
Sbjct: 21473 IKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVY 21532
Query: 340 SCFASNIYGTDSTSAEIYIE 359
+ A N G S AEI ++
Sbjct: 21533 TVEAKNASG--SAKAEIKVK 21550
Score = 40.4 bits (93), Expect = 0.011
Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 26/236 (11%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV--RWYCEGKELENSPDIHIVQAGNL 323
G F ++L+ EVPE +L+CIV P + +WY EL+++ I
Sbjct: 2218 GAVVEFVKELQDIEVPESYSGELECIV---SPENIEGKWYHNDVELKSNGKYTITSRRGR 2274
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAE----IYIEGVSSSD-SEGDPNKEEMN-- 376
+LT+ + +ED G YS T + ++G+S EGD + E+
Sbjct: 2275 QNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVKVS 2334
Query: 377 -------RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--D 427
++ EV VI Q+ L+ + S T GL
Sbjct: 2335 LESVEGVWMKDGQEVQPSDRVHIVID---KQSHMLLIEDMTKEDAGNYSFTIPALGLSTS 2391
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
G+ + + L++++ EG V EC+V V+WY I+ PD R+
Sbjct: 2392 GRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIK--PDDRV 2445
Score = 40.4 bits (93), Expect = 0.011
Identities = 24/97 (24%), Positives = 40/97 (41%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + + EG +T C G P P+V W G++I + + D
Sbjct: 26830 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 26889
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
+L I D G YT+ N G S + ++ ++S+
Sbjct: 26890 TLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 26926
Score = 40.0 bits (92), Expect = 0.015
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 10/93 (10%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLL-------NGQPVLPDAS-HKMLVRETGVHSLLI 1133
M EG + K+ G+P P LTW N +PVL D +K++V +T +L+I
Sbjct: 9629 MEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDT--CTLVI 9686
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
+ D G Y A N G S + L+V+ +
Sbjct: 9687 PQSRRSDTGLYTITAVNNLGTASKEMRLNVLGR 9719
Score = 40.0 bits (92), Expect = 0.015
Identities = 34/140 (24%), Positives = 61/140 (43%), Gaps = 8/140 (5%)
Query: 231 QEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDC 290
+E K+ + AA A G + P + +E L PP+ + G +++++
Sbjct: 12367 KEGKKYKFRVAARNAVGV-SLPREAEGVYEAKEQL-LPPKILMP-EQITIKAGKKLRIEA 12423
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
V G P P +W E+ S + + +A + L I + +D+G YS A N GTD
Sbjct: 12424 HVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTD 12483
Query: 351 STSAEIYIEGVSSSDSEGDP 370
+ ++ + D+ G P
Sbjct: 12484 TQKIKVVV-----MDAPGPP 12498
Score = 40.0 bits (92), Expect = 0.015
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
++ G RL+ VSG PPP + W +G+ + A ++ + + +L+ T+RD+
Sbjct: 14974 VILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFST-NLVNKDSTRRDS 15032
Query: 1142 GTYKCIATNKTG 1153
G Y ATN G
Sbjct: 15033 GAYTLTATNPGG 15044
Score = 40.0 bits (92), Expect = 0.015
Identities = 23/81 (28%), Positives = 36/81 (44%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP F + V G +++D +G P P V W+ + L+ + ++ N LT
Sbjct: 15650 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 15709
Query: 328 IAEAFEEDTGRYSCFASNIYG 348
I +A ED G Y +N G
Sbjct: 15710 IKDACREDVGHYVVKLTNSAG 15730
Score = 39.7 bits (91), Expect = 0.019
Identities = 40/179 (22%), Positives = 72/179 (40%), Gaps = 11/179 (6%)
Query: 184 KLESQNKVMQENSSSFSDLSERRERSSVPIP---IPADTRDNEVNHALEQQEAKRREAEQ 240
++ES+ + E S F+ S + + P+ A D + + +L+ E K + +
Sbjct: 4160 EVESKYLISTEEVSYFNVQSRVKYLDATPVTKGVASAVVSDEKQDESLKPSEEKEESSSE 4219
Query: 241 AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV 300
+ +E + + + P+ P L EG V L + +V
Sbjct: 4220 SGTEEVATVKIQEAEGGLIKEDGPMIHTP-----LVDTVSEEGDIVHLTTSITNAK--EV 4272
Query: 301 RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEED-TGRYSCFASNIYGTDSTSAEIYI 358
WY E K + + +Q N ++L I + ED G Y C A N G +TSA++ +
Sbjct: 4273 NWYFENKLVPSDEKFKCLQDQNTYTLVIDKVNTEDHQGEYVCEALNDSGKTATSAKLTV 4331
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 10/121 (8%)
Query: 1139 RDAGTYK--CIATNKTGQNSFS-LELSVVAKEVKKAPVIL---EKLQNCGVPEGHPVRLE 1192
RD TYK +A N G++ + + V+ K+ + P ++ + + G +RL
Sbjct: 10683 RDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLS 10742
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ G+P P WKK++ P T+ RI + T + L I+ A D G Y+L+ +N A
Sbjct: 10743 AIIKGVPFPKVTWKKEDRDAP-TKARIDV---TPVGSKLEIRNAAHEDGGIYSLTVENPA 10798
Query: 1253 G 1253
G
Sbjct: 10799 G 10799
Score = 39.7 bits (91), Expect = 0.019
Identities = 24/98 (24%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
+E+ P L P + G+ R++ V G P P W G+ + +SH + +
Sbjct: 12397 KEQLLPPKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWK-KGEDEVVTSSHLAVHKAD 12454
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
L+I +T++D+G Y A N +G ++ +++ V+
Sbjct: 12455 SSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVM 12492
Score = 39.7 bits (91), Expect = 0.019
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
VP G PV L + G PPP W + ER+++ + T A L I+ D G
Sbjct: 23253 VPAGRPVELVIPIAGRPPPAASWFFAGSKLR-ESERVTV-ETHTKVAKLTIRETTIRDTG 23310
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
YTL KN G S T ++ I
Sbjct: 23311 EYTLELKNVTGTTSETIKVII 23331
Score = 39.7 bits (91), Expect = 0.019
Identities = 68/316 (21%), Positives = 110/316 (34%), Gaps = 54/316 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG-DGTC 1002
AP R++ RV G F + P +V W+ +G ++ E K+ G
Sbjct: 25876 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQ---ESSKIHYTNTSGVL 25932
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I +DD G Y + N +G S L V + + Q RD
Sbjct: 25933 TLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYAS------------QRRD 25980
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
+E + F P + V+ + ++ S
Sbjct: 25981 EEVPRSVF--PELTRTEAYAVSSFKKTSEMEASSS------------------------- 26013
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ-NSFSLELSVVAKEVKK--APVILEKLQ 1179
VRE V S + + + + A K+ SLE +++K A IL K +
Sbjct: 26014 VRE--VKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPR 26071
Query: 1180 NCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG--YACLLIQPAK 1237
+ V EG R C G P P W + + + + + HQ TT + I +
Sbjct: 26072 SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS----ARHQVTTTKYKSTFEISSVQ 26127
Query: 1238 KSDAGWYTLSAKNEAG 1253
SD G Y++ +N G
Sbjct: 26128 ASDEGNYSVVVENSEG 26143
Score = 39.3 bits (90), Expect = 0.025
Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 11/127 (8%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSR---EVPEGTRVQLDCI 291
R A AA E G+T P + EP +PP + + ++ G +++ +
Sbjct: 8578 RVSAVNAAGEGPPGETQP------VTVAEPQ-EPPAVELDVSVKGGIQIMAGKTLRIPAV 8630
Query: 292 VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDS 351
V G P P W E EL+ + I G L I +A +D GRY A+N G+
Sbjct: 8631 VTGRPVPTKVWTKEEGELDKDRVV-IDNVGTKSELIIKDALRKDHGRYVITATNSCGSKF 8689
Query: 352 TSAEIYI 358
+A + +
Sbjct: 8690 AAARVEV 8696
Score = 38.9 bits (89), Expect = 0.033
Identities = 62/298 (20%), Positives = 114/298 (38%), Gaps = 61/298 (20%)
Query: 951 LKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
LK V EG+ CK+ V V W+ + +QI K ++ + +G L I T
Sbjct: 2405 LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQI-KPDDRVQAIVKGTKQ-RLVINRTH 2462
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
+ D+G Y ++ GR+ + +L V+ + I
Sbjct: 2463 ASDEGPYKLIV----GRVETNCNLSVEKIKI----------------------------- 2489
Query: 1071 FRPHFLQAPGDMVAHEGR--LCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV 1128
++ D+ E + + ++ SG+ ++ W + + P + +K + +
Sbjct: 2490 -----IRGLRDLTCTETQNVVFEVELSHSGI---DVLWNFKDKEIKPSSKYK-IEAHGKI 2540
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
+ L + + + D G Y T G+N S +L+V + K L + V E
Sbjct: 2541 YKLTVLNMMKDDEGKY----TFYAGENMTSGKLTVAGGAISK------PLTDQTVAESQE 2590
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY-ACLLIQPAKKSDAGWYT 1245
EC V P W +D + +P T ++ ++ G+ L+I K D G YT
Sbjct: 2591 AVFECEVAN-PDSKGEWLRDGKHLPLTN---NIRSESDGHKRRLIIAATKLDDIGEYT 2644
Score = 38.9 bits (89), Expect = 0.033
Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 40/222 (18%)
Query: 814 PIPVSPTSRIQNPVAFLSSVLPSLPAIPP---------TNAMGLPRSAPSMPSQGLAKKN 864
P SP R ++PV LPS P+ P T A P P G +
Sbjct: 19571 PSETSPLIRAEDPV-----FLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEY 19625
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTP 924
KS DD +T +R G + T S + + F + +N++ P
Sbjct: 19626 KKS-----DDTDWKTSIQSLR--GTEYTISGLTTGAEYV----FRVKSVNKVG---ASDP 19671
Query: 925 VDESDDEIQHDEIPTGKCIAPIFD---KRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKD 981
D SD +I + P+FD + K V G+ T T G PVP V W K
Sbjct: 19672 SDSSDPQIAKEREEE-----PLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKP 19726
Query: 982 GKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAAN 1023
+ R D SL IE+ +D G YT+ N
Sbjct: 19727 DTDLRTR----AYVDTTDSRTSLTIENANRNDSGKYTLTIQN 19764
Score = 38.9 bits (89), Expect = 0.033
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 5/80 (6%)
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS-LLIDPLTQRDAGTY 1144
+G + RL + G P P W GQ D S + ++ + H+ L+I + D+GTY
Sbjct: 23653 QGGVIRLTIPIKGKPFPICKWTKEGQ----DISKRAMIATSETHTELVIKEADRGDSGTY 23708
Query: 1145 KCIATNKTGQNSFSLELSVV 1164
+ NK G+ + +++ V+
Sbjct: 23709 DLVLENKCGKKAVYIKVRVI 23728
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 8/114 (7%)
Query: 419 PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
PT +Q +D + + K+L L+ G + V G P PK+ W +
Sbjct: 7178 PTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTK-------- 7229
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
D + Q K ++ + T+ I + D+G + A N G +++ +++V
Sbjct: 7230 ADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7283
Score = 38.5 bits (88), Expect = 0.043
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 4/76 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +RL G P P W K + + R +H T ++ L ++ ++DAG
Sbjct: 21872 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSL---RADIHT-TDSFSTLTVENCNRNDAG 21927
Query: 1243 WYTLSAKNEAGIVSCT 1258
YTL+ +N +G S T
Sbjct: 21928 KYTLTVENNSGSKSIT 21943
Score = 38.5 bits (88), Expect = 0.043
Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 5/96 (5%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G+ + LD V G P P++ W KEL+ + + G + I D+G+Y+
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLT 22624
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
N GT + S + + DS G K ++R+
Sbjct: 22625 VKNASGTKAVSVMVKV-----LDSPGPCGKLTVSRV 22655
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/154 (21%), Positives = 71/154 (46%), Gaps = 16/154 (10%)
Query: 1144 YKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKL--QNCGVPE-GHPVRLECRVIGMP 1199
++ A N+ G++ S + A ++++ P + + Q+C V + G +R+ + G P
Sbjct: 9282 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 9341
Query: 1200 PPVFYWKKDNETIPCTRERI------SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
P W+ D + ++ + + + + ++I K+S G Y+++AKN+AG
Sbjct: 9342 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 9401
Query: 1254 IVSCTARLDIYAQWHHQIP-PPMSVRPSGSRYGS 1286
+ R+ + +P PP ++ S GS
Sbjct: 9402 QKTANCRVKVM-----DVPGPPKDLKVSDITRGS 9430
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 9/122 (7%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWY-C 304
A G + P ++ + P PP K EV EGT V + + G+P P + W+
Sbjct: 9599 AAGVSKPSATVGPCDCQRP-DMPPSIDLK-EFMEVEEGTNVNIVAKIKGVPFPTLTWFKA 9656
Query: 305 EGKELENSP----DIHI--VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
K+ +N D H+ + + +L I ++ DTG Y+ A N GT S + +
Sbjct: 9657 PPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNV 9716
Query: 359 EG 360
G
Sbjct: 9717 LG 9718
Score = 38.1 bits (87), Expect = 0.056
Identities = 33/142 (23%), Positives = 65/142 (45%), Gaps = 10/142 (7%)
Query: 1121 MLVRETGVH--SLLIDPLTQRDAGTYKCIATNKTGQNSFS-LELSVVAKEVKKAPVI--- 1174
M TG++ ++ ++ L ++ ++ A NK G + + ++ +E +AP I
Sbjct: 16389 MCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLD 16448
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
LE + + G +RL + G P P W K + I ++ T+ + L++
Sbjct: 16449 LELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEI----RDAAIIDVTSSFTSLVLD 16504
Query: 1235 PAKKSDAGWYTLSAKNEAGIVS 1256
+ D+G YTL+ +N +G S
Sbjct: 16505 NVNRYDSGKYTLTLENSSGTKS 16526
Score = 38.1 bits (87), Expect = 0.056
Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 24/126 (19%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI-DPLTQRD 1140
+V + G RL+ V G P P + WL + + + S + ++ T +LLI + D
Sbjct: 17138 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEI--EESARCEIKNTDFKALLIVKDAIRID 17195
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL------ECR 1194
G Y A+N G SF PV ++ L G PEG PV++ +C
Sbjct: 17196 GGQYILRASNVAGSKSF--------------PVNVKVLDRPGPPEG-PVQVTGVTSEKCS 17240
Query: 1195 VIGMPP 1200
+ PP
Sbjct: 17241 LTWSPP 17246
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
GR L ++G PPP +W G L ++ + T V L I T RD G Y
Sbjct: 23256 GRPVELVIPIAGRPPPAASWFFAGSK-LRESERVTVETHTKVAKLTIRETTIRDTGEYTL 23314
Query: 1147 IATNKTGQNSFSLELSVVAK 1166
N TG S ++++ ++ K
Sbjct: 23315 ELKNVTGTTSETIKVIILDK 23334
Score = 38.1 bits (87), Expect = 0.056
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 9/88 (10%)
Query: 448 EGQLVVFECRVKGAP-SPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
EG V + C+++ S +V WY +E+S + I + + + L + ++
Sbjct: 25084 EGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYE--------DGVAILYVKDIT 25135
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHVRG 534
D G + C N YG SS A+L V+G
Sbjct: 25136 KLDDGTYRCKVVNDYGEDSSYAELFVKG 25163
Score = 37.7 bits (86), Expect = 0.073
Identities = 60/224 (26%), Positives = 88/224 (39%), Gaps = 25/224 (11%)
Query: 157 FIEELSSLFK-SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPI 215
F E L+ L K S SS I+ AC+ K N +++ S +DL + S PI
Sbjct: 11281 FAENLAGLSKPSPSSDPIK--ACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPI 11338
Query: 216 ---------PADTRDNEVNH-ALEQQEAKRREAEQAASE------AAG--GDTTPGSSPS 257
P + N +N L +Q A R +E AA G+ P
Sbjct: 11339 LGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAE 11398
Query: 258 SLYYEEPLGQPPRFTQKLRSREVPE---GTRVQLDCIVVGIPPPQVRWYCEGKELENSPD 314
S+ ++ L PP + R+V G +++ V G P P + W EGK L
Sbjct: 11399 SVIAKDIL-HPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKR 11457
Query: 315 IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+ ++Q L I EA D G+Y A N G SA + +
Sbjct: 11458 VDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNV 11501
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 8/84 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
GQ + RVKG P P + W +EG ++ ++Q PR L I E
Sbjct: 11426 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPR--------VELQIKEAVRA 11477
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
D G + +A N G A ++V
Sbjct: 11478 DHGKYIISAKNSSGHAQGSAIVNV 11501
Score = 37.7 bits (86), Expect = 0.073
Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ +++ +SG P P +TW +G P L + + + +L I + D G Y
Sbjct: 16747 GQDLKIEVPISGRPKPTITWTKDGLP-LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGI 16805
Query: 1147 IATNKTGQNSFSLELSVVAK-EVKKAPV 1173
N GQ + S+E+ + K + K PV
Sbjct: 16806 TVANVVGQKTASIEIVTLDKPDPPKGPV 16833
Score = 37.4 bits (85), Expect = 0.096
Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 17/164 (10%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W+ ++P+ ++K+ E G L Y+ A NK G + S L +
Sbjct: 6841 WIRCNMKLVPELTYKVTGLEKGNKYL------------YRVSAENKAGVSDPSEILGPLT 6888
Query: 1166 KE---VKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+ V+ + V +P+ + G P P W ++ + T +R+ M
Sbjct: 6889 ADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLE-TGDRVKM- 6946
Query: 1223 QDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
+ + YA L+I P+++SD G YTL +N +S +++ A+
Sbjct: 6947 KTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIAR 6990
Score = 37.4 bits (85), Expect = 0.096
Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDAGWY 1244
G +RL V G PPP W K N + R+RI + +T + L + K DAG Y
Sbjct: 13211 GVTMRLYVPVKGRPPPKITWSKPNVNL---RDRIGLDIKSTDFDTFLRCENVNKYDAGKY 13267
Query: 1245 TLSAKNEAG 1253
L+ +N G
Sbjct: 13268 ILTLENSCG 13276
Score = 37.4 bits (85), Expect = 0.096
Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 6/114 (5%)
Query: 1144 YKCIATNKTGQNS-FSLELSVVAKEVKKAPVI-LEKLQNCGV--PEGHPVRLECRVIGMP 1199
++ A N GQ + V AK++ +AP I L+ V G V++ G P
Sbjct: 20743 FRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRP 20802
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
PP W+KD + + + R S+ ++T + L I ++D G Y L+ +N G
Sbjct: 20803 PPTVTWRKDEKNLG-SDARYSI-ENTDSSSLLTIPQVTRNDTGKYILTIENGVG 20854
Score = 37.0 bits (84), Expect = 0.13
Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 21/140 (15%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEP-----LGQPPRFTQKLRSREVPEGTRVQLD 289
R +A A E+ DTT G P++ EEP +G K G+++++
Sbjct: 9283 RVKAVNEAGESEPSDTT-GEIPATDIQEEPEVFIDIGAQDCLVCKA-------GSQIRIP 9334
Query: 290 CIVVGIPPPQVRWYCEGKE-------LENSP-DIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
++ G P P+ W +GK + + P D + A N + I E TG+YS
Sbjct: 9335 AVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSI 9394
Query: 342 FASNIYGTDSTSAEIYIEGV 361
A N G + + + + V
Sbjct: 9395 TAKNKAGQKTANCRVKVMDV 9414
Score = 37.0 bits (84), Expect = 0.13
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
I P + V G + I G P P + W KDG + K+ + D T
Sbjct: 16731 IEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPL-KQTTRINVTDSLDLT- 16788
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+L I+ T DD G Y I AN G+ + S ++ P
Sbjct: 16789 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKP 16826
Score = 37.0 bits (84), Expect = 0.13
Identities = 45/176 (25%), Positives = 76/176 (43%), Gaps = 12/176 (6%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP-LTQRD 1140
++A G ++ G PPP +TW + + + DA + + T SLL P +T+ D
Sbjct: 20784 VIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYS--IENTDSSSLLTIPQVTRND 20841
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRL--ECRVIGM 1198
G Y N G+ + S V+ +V P +KLQ V G L + G
Sbjct: 20842 TGKYILTIENGVGEP----KSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGG 20897
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
P + Y + + T +S +T + LI ++K+ ++ + A+NE GI
Sbjct: 20898 SPIINYVIEKRDATKRTWSVVSHKCSSTSFK--LIDLSEKTPF-FFRVLAENEIGI 20950
Score = 36.6 bits (83), Expect = 0.16
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 3/85 (3%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G P+ + G P PKV W K G R + D L I ++T DD G
Sbjct: 12121 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLV---DTMAFLVIPNSTRDDSG 12177
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y++ NP G + ++ V P
Sbjct: 12178 KYSLTLVNPAGEKAVFVNVRVLDTP 12202
Score = 36.6 bits (83), Expect = 0.16
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G +++ V G P P ++W+ +G+P+ + ++ V ET ++L I + D G Y
Sbjct: 17829 GEDLKIEIPVIGRPRPNISWVKDGEPL--KQTTRVNVEETATSTVLHIKEGNKDDFGKYT 17886
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
ATN G + +L + V+ K
Sbjct: 17887 VTATNSAGTATENLSVIVLEK 17907
Score = 36.6 bits (83), Expect = 0.16
Identities = 33/131 (25%), Positives = 60/131 (45%), Gaps = 16/131 (12%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG----QNSFSLELSVVAKEVKKAPV-----ILEKLQNCGV 1183
++ L ++ ++ A N G + +FS SV+ KE + P I +L C
Sbjct: 22108 VERLVEKTEYEFRVKAKNDAGYSEPREAFS---SVIIKEPQIEPTADLTGITNQLITCKA 22164
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
G P ++ + G P P WK + + T +R+S+ T L ++ + + D+G
Sbjct: 22165 --GSPFTIDVPISGRPAPKVTWKLEEMRLKET-DRVSI-TTTKDRTTLTVKDSMRGDSGR 22220
Query: 1244 YTLSAKNEAGI 1254
Y L+ +N AG+
Sbjct: 22221 YFLTLENTAGV 22231
Score = 36.6 bits (83), Expect = 0.16
Identities = 26/69 (37%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKK-DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G + L+ V G P P W K D E C E++S+ Q T A +I+ +SD+G Y
Sbjct: 22565 GSDLVLDAAVGGKPEPKIIWTKGDKELDLC--EKVSL-QYTGKRATAVIKFCDRSDSGKY 22621
Query: 1245 TLSAKNEAG 1253
TL+ KN +G
Sbjct: 22622 TLTVKNASG 22630
Score = 36.2 bits (82), Expect = 0.21
Identities = 51/221 (23%), Positives = 85/221 (38%), Gaps = 40/221 (18%)
Query: 853 PSMPSQGLAKKN--TKSPQPVNDDNIRETKNAVI-------RDLGKKITFSDV---RPNQ 900
PS PS+ + K+ K PVN + I T N+V D G KI V +
Sbjct: 10600 PSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGD 10659
Query: 901 QEYKISSFEQRLMNEIEFRL--------------------ERTPVDESDDEIQHDEIPTG 940
+E++ ++ E ++++ E P + + D +
Sbjct: 10660 EEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPP 10719
Query: 941 KCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG 1000
+ I R +H +V G + + I G+P PKV W K+ R+ K R +
Sbjct: 10720 ELILDANMAREQHIKV--GDTLRLSAIIKGVPFPKVTWKKE-----DRDAPTKARIDVTP 10772
Query: 1001 TCS-LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S L I + +D G Y++ NP G + S ++V P
Sbjct: 10773 VGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKP 10813
Score = 35.8 bits (81), Expect = 0.28
Identities = 20/83 (24%), Positives = 35/83 (42%), Gaps = 1/83 (1%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V G R + G+P P W +G + D H + + L I +RD
Sbjct: 11023 LVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTD-EHYTVETDNFSSVLTIKNCLRRDT 11081
Query: 1142 GTYKCIATNKTGQNSFSLELSVV 1164
G Y+ +N G + ++ L+V+
Sbjct: 11082 GEYQITVSNAAGSKTVAVHLTVL 11104
Score = 35.8 bits (81), Expect = 0.28
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Query: 968 IVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
I+G P+PK W K GK I R + L I+ T D G YTI A NP G
Sbjct: 13906 ILGKPLPKSSWSKAGKDI--RPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 13962
Score = 35.8 bits (81), Expect = 0.28
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 9/127 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELS--VVAKEVKKAPVIL---EKLQNCGVPEGH 1187
+ LT+ ++ IA N G S + + + AK+ + P I + V G
Sbjct: 17085 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 17144
Query: 1188 PVRLECRVIGMPPPVFYW-KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
RLE V G P P W + D E R I ++T A L+++ A + D G Y L
Sbjct: 17145 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEI---KNTDFKALLIVKDAIRIDGGQYIL 17201
Query: 1247 SAKNEAG 1253
A N AG
Sbjct: 17202 RASNVAG 17208
Score = 35.4 bits (80), Expect = 0.36
Identities = 41/162 (25%), Positives = 70/162 (43%), Gaps = 19/162 (11%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV- 1164
W+ G+PV A KM V TG L + Y+ A N+ G + S +
Sbjct: 7137 WVACGEPV---AETKMEV--TG--------LEEGKWYAYRVKALNRQGASKPSRPTEEIQ 7183
Query: 1165 AKEVKKAPVI---LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
A + ++AP I ++ L V G + L V G P P W K + + + RI++
Sbjct: 7184 AVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDK-RITI 7242
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
++ + + I +K+SD G Y + A N G + +++
Sbjct: 7243 -ENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNV 7283
Score = 35.4 bits (80), Expect = 0.36
Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G I G P+P + W K +++S N + D SL ++ D G
Sbjct: 16058 VHAGESFKVDADIYGKPIPTIQWIKGDQELS--NTARLEIKSTDFATSLSVKDAVRVDSG 16115
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
NY + A N G S + ++ V P
Sbjct: 16116 NYILKAKNVAGERSVTVNVKVLDRP 16140
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/94 (21%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
K ++ P + S GQ + E + G P P + W ++G ++ + +
Sbjct: 16727 KDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINV----- 16781
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ ++ TL I E +D G + T +N G
Sbjct: 16782 ---TDSLDLTTLSIKETHKDDGGQYGITVANVVG 16812
Score = 35.4 bits (80), Expect = 0.36
Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 6/111 (5%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRD 1140
+V G + +++ ++G P P ++W +G + A +++ T H+LL + +RD
Sbjct: 19302 IVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEII--STDNHTLLTVKDCIRRD 19359
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKA-PVILEKL--QNCGVPEGHP 1188
G Y N G S ++ V+ K A P+ + L + C + G P
Sbjct: 19360 TGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRP 19410
Score = 35.4 bits (80), Expect = 0.36
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 4/72 (5%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +G + T I G P P W K+G+ ISKR M + L I+ D G
Sbjct: 23651 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKR----AMIATSETHTELVIKEADRGDSG 23706
Query: 1016 NYTIMAANPQGR 1027
Y ++ N G+
Sbjct: 23707 TYDLVLENKCGK 23718
Score = 35.4 bits (80), Expect = 0.36
Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 1/78 (1%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE-DTGRYSC 341
G+ ++L + +G P P + W+ K L+NS +I I + L + + G+Y
Sbjct: 24146 GSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKV 24205
Query: 342 FASNIYGTDSTSAEIYIE 359
SN++GT ++ I+
Sbjct: 24206 QLSNVFGTVDAILDVEIQ 24223
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 11/99 (11%)
Query: 437 FTKMLQNLSASEGQ-LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
FT+ LQ++ A E + FEC P KV+WY++G + + +R+ S +
Sbjct: 2130 FTQELQDVVAKEKDTMATFECETS-EPFVKVKWYKDGMEVHEGDKYRM-----HSDRKVH 2183
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ L I AED C N V + A+L V G
Sbjct: 2184 FLSILTIDTSDAEDYSCVLVEDEN----VKTTAKLIVEG 2218
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVH-SLLIDPLTQRDA 1141
+A E RL + G P P ++W P+ D ++ V + V+ +L++ + DA
Sbjct: 13496 LAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT--RVSVESSAVNTTLIVYDCQKSDA 13553
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAK 1166
G Y N G ++ + VV K
Sbjct: 13554 GKYTITLKNVAGTKEGTISIKVVGK 13578
Score = 35.0 bits (79), Expect = 0.48
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP---VILEKLQNCGVP 1184
+ ++ L ++ ++ A N G ++ V E + AP + E + V
Sbjct: 14233 ITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVR 14292
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
G +R+ + G P P W KDN + + R ++ ++T + L+I + D G +
Sbjct: 14293 AGLSIRIFVPIKGRPAPEVTWTKDNINL---KNRANI-ENTESFTLLIIPECNRYDTGKF 14348
Query: 1245 TLSAKNEAG 1253
++ +N AG
Sbjct: 14349 VMTIENPAG 14357
Score = 35.0 bits (79), Expect = 0.48
Identities = 29/129 (22%), Positives = 47/129 (36%), Gaps = 8/129 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I P++ + D V K + G+ E V G P
Sbjct: 14934 VIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPP 14993
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW ++G +E + I + LV + DSG +T TA+N G
Sbjct: 14994 PTMEWSKDGKELEGTAKLEI--------KIADFSTNLVNKDSTRRDSGAYTLTATNPGGF 15045
Query: 524 VSSIAQLHV 532
I + V
Sbjct: 15046 AKHIFNVKV 15054
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G ++D + G P P + W + G L + + + SL + + D+
Sbjct: 16056 IVVHAGESFKVDADIYGKPIPTIQW-IKGDQELSNTARLEIKSTDFATSLSVKDAVRVDS 16114
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKE-VKKAPVIL 1175
G Y A N G+ S ++ + V+ + + PV++
Sbjct: 16115 GNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI 16149
Score = 35.0 bits (79), Expect = 0.48
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G +++ + G P PV W KD I R R + T + L ++ + D G
Sbjct: 19304 VKAGEVLKINADIAGRPLPVISWAKDGIEIE-ERARTEI-ISTDNHTLLTVKDCIRRDTG 19361
Query: 1243 WYTLSAKNEAG 1253
Y L+ KN AG
Sbjct: 19362 QYVLTLKNVAG 19372
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 18/106 (16%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIV------------------VGIPPPQVRWYCEGK 307
G+P + ++++++ E + LD + G PPP V W + K
Sbjct: 20754 GEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEK 20813
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
L + I + LTI + DTG+Y N G +S
Sbjct: 20814 NLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSS 20859
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/99 (24%), Positives = 47/99 (47%), Gaps = 8/99 (8%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR- 1139
D++ EG + +P P ++W +G+ V AS ++ ++ + + L P + R
Sbjct: 7898 DIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEV--KASDRLTMKNDHISAHLEVPKSVRA 7955
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVV-----AKEVKKAPV 1173
DAG Y NK G + S+ + V+ K++K + +
Sbjct: 7956 DAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDI 7994
Score = 34.7 bits (78), Expect = 0.62
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 14/144 (9%)
Query: 890 KITFSDVRPNQQEYKIS------SFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCI 943
K FS++ N E+ +S ++E R++ + P + SD D++ K
Sbjct: 14908 KANFSNILEN--EFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIK 14965
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMR-REGDGTC 1002
+ K + G + G P P + W KDGK++ K+ + D +
Sbjct: 14966 VDVKFKDTVILKA--GEAFRLEADVSGRPPPTMEWSKDGKELEGT---AKLEIKIADFST 15020
Query: 1003 SLHIESTTSDDDGNYTIMAANPQG 1026
+L + +T D G YT+ A NP G
Sbjct: 15021 NLVNKDSTRRDSGAYTLTATNPGG 15044
Score = 34.7 bits (78), Expect = 0.62
Identities = 23/82 (28%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDA 1241
V G +++ + G P P W K ++ + T + +T +A L ++ A + D+
Sbjct: 16058 VHAGESFKVDADIYGKPIPTIQWIKGDQELSNTAR---LEIKSTDFATSLSVKDAVRVDS 16114
Query: 1242 GWYTLSAKNEAGIVSCTARLDI 1263
G Y L AKN AG S T + +
Sbjct: 16115 GNYILKAKNVAGERSVTVNVKV 16136
Score = 34.7 bits (78), Expect = 0.62
Identities = 24/78 (30%), Positives = 30/78 (38%), Gaps = 2/78 (2%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
K V G PV I G P P WF G ++ + +E + L I TT
Sbjct: 23249 KTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKL-RESERVTVETH-TKVAKLTIRETTI 23306
Query: 1012 DDDGNYTIMAANPQGRIS 1029
D G YT+ N G S
Sbjct: 23307 RDTGEYTLELKNVTGTTS 23324
Score = 34.3 bits (77), Expect = 0.81
Identities = 67/299 (22%), Positives = 109/299 (36%), Gaps = 33/299 (11%)
Query: 238 AEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-GTRVQLDCIVVGIP 296
AE +AS G + S + Q FTQ+L+ E T +C P
Sbjct: 2097 AEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFEC-ETSEP 2155
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
+V+WY +G E+ + +H L+I D YSC T+A++
Sbjct: 2156 FVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENV-KTTAKL 2214
Query: 357 YIEGV------SSSDSE-GDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPR 409
+EG D E + E+ I P + + V ++ + R
Sbjct: 2215 IVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEGKWYHNDV--ELKSNGKYTITSRR 2272
Query: 410 VATIQQCQSPTNYLQG-----LDGK----PIIAAPVFTKMLQNLS---ASEGQLVVFECR 457
+ T QG +DGK + P +LQ LS EG +V E +
Sbjct: 2273 GRQNLTVKDVTKEDQGEYSFVIDGKKTTCKLKMKPRPIAILQGLSDQKVCEGDIVQLEVK 2332
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
V S + W ++G ++ S I+ K M L+I ++ ED+G ++ T
Sbjct: 2333 V-SLESVEGVWMKDGQEVQPSDRVHIVIDKQSHM--------LLIEDMTKEDAGNYSFT 2382
Score = 34.3 bits (77), Expect = 0.81
Identities = 28/137 (20%), Positives = 53/137 (38%), Gaps = 9/137 (6%)
Query: 398 VPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECR 457
VP ++ V + R P+ + + K P ++ EG+ +
Sbjct: 7854 VPDKEY-VLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVP 7912
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+ P P V W+++G ++ S R+ K A L + + D+G +T T
Sbjct: 7913 FRAVPVPTVSWHKDGKEVKASD--RLTMKNDHISAH------LEVPKSVRADAGIYTITL 7964
Query: 518 SNKYGTVSSIAQLHVRG 534
NK G+ ++ + V G
Sbjct: 7965 ENKLGSATASINVKVIG 7981
Score = 34.3 bits (77), Expect = 0.81
Identities = 19/82 (23%), Positives = 38/82 (46%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V EG ++ + +P P V W+ +GKE++ S + + L + ++ D G Y
Sbjct: 7901 VIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 7960
Query: 340 SCFASNIYGTDSTSAEIYIEGV 361
+ N G+ + S + + G+
Sbjct: 7961 TITLENKLGSATASINVKVIGL 7982
Score = 34.3 bits (77), Expect = 0.81
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 10/92 (10%)
Query: 268 PPRFTQKLRSR----EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI------HI 317
PP +L R +V G V + V G+P P++ W +E D +
Sbjct: 8897 PPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEV 8956
Query: 318 VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
++ L+I +A ED G Y+ ASN G+
Sbjct: 8957 SRSEAKTELSIPKAVREDKGTYTVTASNRLGS 8988
Score = 34.3 bits (77), Expect = 0.81
Identities = 36/153 (23%), Positives = 57/153 (37%), Gaps = 6/153 (3%)
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQN--SFSLEL 1161
+ ++L + + + HK+ + L + D Y+ A N GQ SF +
Sbjct: 10252 INYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKP 10311
Query: 1162 SVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
E+ + L+ + G L R G P P W KD + E
Sbjct: 10312 ITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADV---LEDDRT 10368
Query: 1222 HQDTTGYACLLIQ-PAKKSDAGWYTLSAKNEAG 1253
H TT L + AK+SD+G Y + +N G
Sbjct: 10369 HIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 10401
Score = 34.3 bits (77), Expect = 0.81
Identities = 21/106 (19%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 428 GKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
G P+I P+ +T++++ + G V + G P+P +EWY++ D +
Sbjct: 20371 GGPVIDLPLEYTEVVKYRA---GTSVKLRAGISGKPAPTIEWYKD--------DKELQTN 20419
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ ++ +++I + +SGC+ N G+ S+ ++ +
Sbjct: 20420 ALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQI 20465
Score = 34.3 bits (77), Expect = 0.81
Identities = 22/65 (33%), Positives = 25/65 (38%), Gaps = 2/65 (3%)
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
GH V LE G P P W KD +P T L I+ AKK G YT
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT 21138
Query: 1246 LSAKN 1250
+ N
Sbjct: 21139 VILDN 21143
Score = 34.3 bits (77), Expect = 0.81
Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 246 AGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRW 302
AGG P P ++ E L + P + R +E V +G ++L + G P P +W
Sbjct: 23615 AGGPGEPAEVPGTVKVTEML-EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKW 23673
Query: 303 YCEGKELENSPDIHIVQAGNLHS-LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
EG+++ ++ H+ L I EA D+G Y N G + ++ + G
Sbjct: 23674 TKEGQDISKRA---MIATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 23730
Query: 362 SSS 364
+S
Sbjct: 23731 PNS 23733
Score = 34.3 bits (77), Expect = 0.81
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V +G +RL + G P P+ W K+ + I + +M + + L+I+ A + D+G
Sbjct: 23651 VRQGGVIRLTIPIKGKPFPICKWTKEGQDI----SKRAMIATSETHTELVIKEADRGDSG 23706
Query: 1243 WYTLSAKNEAG 1253
Y L +N+ G
Sbjct: 23707 TYDLVLENKCG 23717
Score = 34.3 bits (77), Expect = 0.81
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 5/111 (4%)
Query: 1057 RVQERDKEPL-QERFFRPHFLQAPGDMVAHE---GRLCRLDCKVSGLPPPELTWLLNGQP 1112
+ ER E L Q+ F H + M +H G+ R V P E+ W NG
Sbjct: 25857 KTSERKYEVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVE 25916
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
L ++S +GV +L I D+GTY+ + TN G+ S L V
Sbjct: 25917 -LQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDV 25966
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/74 (24%), Positives = 31/74 (41%), Gaps = 1/74 (1%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F + L + V E C + V+WY G+E++ + G++H L
Sbjct: 6325 PTEFVEHLEDQTVTEFDDAVFSC-QLSREKANVKWYRNGREIKEGKKYKFEKDGSIHRLI 6383
Query: 328 IAEAFEEDTGRYSC 341
I + +D Y+C
Sbjct: 6384 IKDCRLDDECEYAC 6397
Score = 33.9 bits (76), Expect = 1.1
Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 1/88 (1%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
++D G P + W +GQ L + + + V SL I ++ D GTY+ +N
Sbjct: 18916 KIDVPFKGRPQATVNWRKDGQ-TLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSN 18974
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEKL 1178
G + + + V+ + P+ ++++
Sbjct: 18975 SAGSITVPITIIVLDRPGPPGPIRIDEV 19002
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/63 (28%), Positives = 29/63 (46%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V L+ G P P + W +G L+ S + + N +L+I A +E G+Y+
Sbjct: 21081 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 21140
Query: 343 ASN 345
N
Sbjct: 21141 LDN 21143
Score = 33.5 bits (75), Expect = 1.4
Identities = 22/94 (23%), Positives = 38/94 (40%), Gaps = 8/94 (8%)
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
K+++ L G V F ++G P P +W +G+ I+ + + S+
Sbjct: 11018 KLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSV------- 11070
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L I D+G + T SN G+ + L V
Sbjct: 11071 -LTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTV 11103
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 13/103 (12%)
Query: 428 GKPIIAA-----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
G P+IA P S G+ + E V G P P + W ++G ++
Sbjct: 17803 GVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLK------ 17856
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
Q ++ E L I E +D G +T TA+N GT +
Sbjct: 17857 --QTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 17897
Score = 33.5 bits (75), Expect = 1.4
Identities = 27/103 (26%), Positives = 40/103 (38%), Gaps = 3/103 (2%)
Query: 924 PVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGK 983
P D S DEI A + K V G I G P+P V W KDGK
Sbjct: 18192 PSDSSGAITARDEIDAPN--ASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGK 18249
Query: 984 QISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
++ + +++ T +L ++ D G Y + +N G
Sbjct: 18250 ELEETAARMEIKSTIQKT-TLVVKDCIRTDGGQYILKLSNVGG 18291
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 14/105 (13%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+V H G L+ + G P P++ W +G+ + A+ + +L++ + D
Sbjct: 18220 IVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDG 18279
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
G Y +N G K P+ ++ L G PEG
Sbjct: 18280 GQYILKLSNVGG--------------TKSIPITVKVLDRPGPPEG 18310
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/74 (28%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V G LE + G P P W KD + + T R+ + + T L+++ ++D G
Sbjct: 18222 VHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEI-KSTIQKTTLVVKDCIRTDGG 18280
Query: 1243 WYTLSAKNEAGIVS 1256
Y L N G S
Sbjct: 18281 QYILKLSNVGGTKS 18294
Score = 33.5 bits (75), Expect = 1.4
Identities = 36/169 (21%), Positives = 67/169 (39%), Gaps = 17/169 (10%)
Query: 873 DDNIRETKNAVIRDLGKKITFSDVRPNQQ-EYKISSFEQRLMNEIEFRLERTPVDESDDE 931
D R NA IR+ + T D++ Q+ +++++ + M+E + +
Sbjct: 22889 DQWYRVHTNATIRNT--EFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEI------EP 22940
Query: 932 IQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEH 991
++ EIP + D K + G+ + + G P P + W K G ++ R
Sbjct: 22941 VERIEIPD----LELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASR--- 22993
Query: 992 CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ + L ++ D G YTI A N G+ S + + V P
Sbjct: 22994 -AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTP 23041
Score = 33.1 bits (74), Expect = 1.8
Identities = 27/107 (25%), Positives = 38/107 (35%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
DK L P + +G +V G P PE W NG +
Sbjct: 2021 DKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYW 2080
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV 1168
E V L+I +T D+ + A N G+ S L V AK++
Sbjct: 2081 YWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQL 2127
Score = 33.1 bits (74), Expect = 1.8
Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 4/113 (3%)
Query: 917 EFRLERTPVDESDDEIQHDEIPTGKCIA-PIFDKRLKH-FRVTEGSPVTFTCKIVGIPVP 974
EFR++ D ++ +E+ + + P+ D +L V G + + G P P
Sbjct: 11675 EFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFP 11734
Query: 975 KVYWFKDGKQIS-KRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
+V W KD R+ K+ D + + D G Y + A N G
Sbjct: 11735 EVAWTKDKDATDLTRSPRVKIDTRADSS-KFSLTKAKRSDGGKYVVTATNTAG 11786
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 440 MLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT 499
M + ++ G+ + E V G P P +W + + S + + S+
Sbjct: 12407 MPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI-------- 12458
Query: 500 LVIAEVFAEDSGCFTCTASNKYGT 523
L+I +V +DSG ++ TA N GT
Sbjct: 12459 LIIKDVTRKDSGYYSLTAENSSGT 12482
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/87 (26%), Positives = 32/87 (36%), Gaps = 8/87 (9%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDG---KQISKRNEHCKMRREGD 999
I P F F V G + +G P P V W KD KQ ++ N +
Sbjct: 15649 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVN-----AESTE 15703
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQG 1026
L I+ +D G+Y + N G
Sbjct: 15704 NNSLLTIKDACREDVGHYVVKLTNSAG 15730
Score = 33.1 bits (74), Expect = 1.8
Identities = 21/75 (28%), Positives = 33/75 (44%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V+W + I D+ + +LV+ V DSG +T T
Sbjct: 16469 IKGRPTPEVKWGKVDGEIRDAAIIDV----------TSSFTSLVLDNVNRYDSGKYTLTL 16518
Query: 518 SNKYGTVSSIAQLHV 532
N GT S+ + V
Sbjct: 16519 ENSSGTKSAFVTVRV 16533
Score = 33.1 bits (74), Expect = 1.8
Identities = 23/99 (23%), Positives = 39/99 (39%), Gaps = 5/99 (5%)
Query: 945 PIFDKRLKHFRVTE---GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
P+ D L++ V + G+ V I G P P + W+KD K++ C
Sbjct: 20373 PVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCV--ENTTDL 20430
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
S+ I+ + G Y + N G S + + + P
Sbjct: 20431 ASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKP 20469
Score = 33.1 bits (74), Expect = 1.8
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 15/184 (8%)
Query: 1147 IATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWK 1206
+ T KT + + + LS + AP I ++++ VP G R V P W
Sbjct: 25853 LKTQKTSERKYEV-LSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWY 25911
Query: 1207 KDNETIPCTRERISMHQ-DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI-- 1263
+ + +E +H +T+G L I D+G Y N G S A LD+
Sbjct: 25912 HNGVEL---QESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTG 25968
Query: 1264 -----YAQWHHQIPPPMSVRPSGSR---YGSLTSKGLDIFSAFSSMESTMVYSCSSRSVV 1315
YA P SV P +R Y + K A SS+ +R +
Sbjct: 25969 GDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESL 26028
Query: 1316 ESDE 1319
S E
Sbjct: 26029 SSYE 26032
Score = 32.7 bits (73), Expect = 2.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G+ R+ +V G P P++TW G+ VL L+++ L I + D G Y
Sbjct: 11426 GQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLPRVELQIKEAVRADHGKYII 11484
Query: 1147 IATNKTGQNSFSLELSVV 1164
A N +G S ++V+
Sbjct: 11485 SAKNSSGHAQGSAIVNVL 11502
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 1133 IDPLTQRDAGTYKCIATNKTG-QNSFSLELSVVAKEVKKAPVI-----LEKLQNCGVPEG 1186
+ L + ++ A N+ G L+ ++ KE+ + P I + KL V G
Sbjct: 12067 VTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVI--VRAG 12124
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
P+RL V G P P W+K + ++ + DT + L+I + + D+G Y+L
Sbjct: 12125 CPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDL-VDTMAF--LVIPNSTRDDSGKYSL 12181
Query: 1247 SAKNEAG 1253
+ N AG
Sbjct: 12182 TLVNPAG 12188
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 9/81 (11%)
Query: 444 LSASEGQLVVFEC-RVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L+ G +V + G P PK W + G I S +I SM L I
Sbjct: 13891 LTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSM--------LTI 13942
Query: 503 AEVFAEDSGCFTCTASNKYGT 523
+D+G +T TA+N +GT
Sbjct: 13943 KYATRKDAGEYTITATNPFGT 13963
Score = 32.7 bits (73), Expect = 2.4
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 14/127 (11%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++++ V+G P P V W + L+ + ++ L I E D+G Y
Sbjct: 14583 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 14642
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP----AV 398
A NI G I + D G P K +EVSS T + PP V
Sbjct: 14643 ARNIVGEVGDVITIQVH-----DIPGPPTGP-----IKFDEVSSDFVTFSWDPPENDGGV 14692
Query: 399 PQAQHLV 405
P + ++V
Sbjct: 14693 PISNYVV 14699
Score = 32.7 bits (73), Expect = 2.4
Identities = 26/122 (21%), Positives = 46/122 (37%), Gaps = 8/122 (6%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
++A+ I + T + D + + K + + G+ E V G P
Sbjct: 17098 VIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPL 17157
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P +EW R IE+S I +++ L++ + D G + ASN G+
Sbjct: 17158 PTIEWLRGDKEIEESARCEIKNTDFKAL--------LIVKDAIRIDGGQYILRASNVAGS 17209
Query: 524 VS 525
S
Sbjct: 17210 KS 17211
Score = 32.7 bits (73), Expect = 2.4
Identities = 36/131 (27%), Positives = 53/131 (40%), Gaps = 10/131 (7%)
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVI---LEKLQNCGVPEGHP 1188
I LT ++ + NK G + S +AKE ++ P+ E + V G
Sbjct: 19647 ISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 19706
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTT-GYACLLIQPAKKSDAGWYTLS 1247
+ G P P W K P T R + DTT L I+ A ++D+G YTL+
Sbjct: 19707 FTMTVPFRGRPVPNVLWSK-----PDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLT 19761
Query: 1248 AKNEAGIVSCT 1258
+N S T
Sbjct: 19762 IQNVLSAASLT 19772
Score = 32.7 bits (73), Expect = 2.4
Identities = 28/151 (18%), Positives = 56/151 (37%), Gaps = 8/151 (5%)
Query: 383 EVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
+VS T + P ++A+ V TI + + D +
Sbjct: 21410 DVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFD 21469
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
L G+ + + V+G P P+V W+++G IE + I + +L +
Sbjct: 21470 GLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGST--------SLFV 21521
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ + G +T A N G+ + ++ V+
Sbjct: 21522 RDATRDHRGVYTVEAKNASGSAKAEIKVKVQ 21552
Score = 32.7 bits (73), Expect = 2.4
Identities = 24/94 (25%), Positives = 38/94 (40%), Gaps = 10/94 (10%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ + +G ++ +KG P P +W +EG I K +A E LV
Sbjct: 23647 EGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDI----------SKRAMIATSETHTELV 23696
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGN 535
I E DSG + NK G + ++ V G+
Sbjct: 23697 IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS 23730
Score = 32.3 bits (72), Expect = 3.1
Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 5/81 (6%)
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYK 1145
G RL + G+P P++TW + DA K + T V S L I D G Y
Sbjct: 10736 GDTLRLSAIIKGVPFPKVTWKKEDR----DAPTKARIDVTPVGSKLEIRNAAHEDGGIYS 10791
Query: 1146 CIATNKTGQNSFSLELSVVAK 1166
N G + S+++ V+ K
Sbjct: 10792 LTVENPAGSKTVSVKVLVLDK 10812
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCE--GKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V G ++L+ V G P P+V W + +L SP + I + ++ +A D G
Sbjct: 11716 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 11775
Query: 338 RYSCFASNIYGT 349
+Y A+N G+
Sbjct: 11776 KYVVTATNTAGS 11787
Score = 32.3 bits (72), Expect = 3.1
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 7/77 (9%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+ V E ++G P P V W ++G +E++ + + TLV+ +
Sbjct: 18225 GETFVLEADIRGKPIPDVVWSKDGKELEET-------AARMEIKSTIQKTTLVVKDCIRT 18277
Query: 509 DSGCFTCTASNKYGTVS 525
D G + SN GT S
Sbjct: 18278 DGGQYILKLSNVGGTKS 18294
Score = 32.3 bits (72), Expect = 3.1
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 9/120 (7%)
Query: 1047 SAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA-HEGRLCRLDCKVSGLPPPELT 1105
S G G ++ P E R H GD+V G LD V G P P++
Sbjct: 22529 SKGSESTGPVTCRDEYAPPKAELDARLH-----GDLVTIRAGSDLVLDAAVGGKPEPKII 22583
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR-DAGTYKCIATNKTGQNSFSLELSVV 1164
W + + D K+ ++ TG + + R D+G Y N +G + S+ + V+
Sbjct: 22584 WTKGDKEL--DLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVL 22641
Score = 32.0 bits (71), Expect = 4.0
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
++ L + V E +C V P + W +GK L + +I G+ L IA
Sbjct: 2577 SKPLTDQTVAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAAT 2635
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
+D G Y+ + T TSA++ +E V
Sbjct: 2636 KLDDIGEYTYKVA----TSKTSAKLKVEAV 2661
Score = 32.0 bits (71), Expect = 4.0
Identities = 27/131 (20%), Positives = 52/131 (39%), Gaps = 10/131 (7%)
Query: 232 EAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCI 291
EA+RR+ + GG+ P +P + + P +F ++++ + E V I
Sbjct: 4588 EAERRKLRPGS----GGEKPPDEAPFTYQLK---AVPLKFVKEIKDIILTESEFVGSSAI 4640
Query: 292 VVGIPPPQVR---WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYG 348
+ P W +G + SP + G L I + D G Y+C
Sbjct: 4641 FECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNK 4700
Query: 349 TDSTSAEIYIE 359
+++A++ +E
Sbjct: 4701 EKTSTAKLVVE 4711
Score = 32.0 bits (71), Expect = 4.0
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 13/95 (13%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
RL + G P PE+ W + +L D + + + L+ID +T+ D+G Y N
Sbjct: 18629 RLFVTIKGRPEPEVKWE-KAEGILTDRAQIEVT--SSFTMLVIDNVTRFDSGRYNLTLEN 18685
Query: 1151 KTGQ----------NSFSLELSVVAKEVKKAPVIL 1175
+G +S S +++ +EVKK V L
Sbjct: 18686 NSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTL 18720
Score = 32.0 bits (71), Expect = 4.0
Identities = 42/197 (21%), Positives = 71/197 (36%), Gaps = 33/197 (16%)
Query: 967 KIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQG 1026
KIVG + K +Q ++R C + C + + D + I+A N G
Sbjct: 21388 KIVGYSIEK-------RQGNERWVRCNFTDVSE--CQYTVTGLSPGDRYEFRIIARNAVG 21438
Query: 1027 RISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHE 1086
IS P +S G ++ + P+ E F P + ++
Sbjct: 21439 TISP---------PSQSS---------GIIMTRDENVPPIVE--FGPEYFDG---LIIKS 21475
Query: 1087 GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
G R+ V G P P +TW +G + + + G SL + T+ G Y
Sbjct: 21476 GESLRIKALVQGRPVPRVTWFKDGVEI-EKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 21534
Query: 1147 IATNKTGQNSFSLELSV 1163
A N +G +++ V
Sbjct: 21535 EAKNASGSAKAEIKVKV 21551
Score = 32.0 bits (71), Expect = 4.0
Identities = 18/75 (24%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
+D +SG P P++TW L + L + + +L + + D+G Y N
Sbjct: 22170 IDVPISGRPAPKVTWKLE-EMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 22228
Query: 1152 TGQNSFSLELSVVAK 1166
G +FS+ + V+ +
Sbjct: 22229 AGVKTFSVTVVVIGR 22243
Score = 31.6 bits (70), Expect = 5.3
Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 8/90 (8%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE-EICTLVI 502
L+ G + E V+G P P+V W ++ +D+ D L + PR + + +
Sbjct: 11714 LTVKAGDTIRLEAGVRGKPFPEVAWTKD----KDATD---LTRSPRVKIDTRADSSKFSL 11766
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ D G + TA+N G+ + A ++V
Sbjct: 11767 TKAKRSDGGKYVVTATNTAGSFVAYATVNV 11796
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 10/75 (13%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P+P+V W ++ I K ++ E L+I E D+G F T
Sbjct: 14303 IKGRPAPEVTWTKDN----------INLKNRANIENTESFTLLIIPECNRYDTGKFVMTI 14352
Query: 518 SNKYGTVSSIAQLHV 532
N G S + V
Sbjct: 14353 ENPAGKKSGFVNVRV 14367
Score = 31.6 bits (70), Expect = 5.3
Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 10/101 (9%)
Query: 458 VKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
+KG P P+V+W + ++ D + LVI V DSG + T
Sbjct: 18634 IKGRPEPEVKWEKAEGILTDRAQIEV----------TSSFTMLVIDNVTRFDSGRYNLTL 18683
Query: 518 SNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEP 558
N G+ ++ + V + N ++ + + EP
Sbjct: 18684 ENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEP 18724
Score = 31.6 bits (70), Expect = 5.3
Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 13/97 (13%)
Query: 429 KPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
KP + P T N+ A E QL + + KG P V W ++G ++++ + K
Sbjct: 18897 KPSVELPFHTF---NVKARE-QLKI-DVPFKGRPQATVNWRKDGQTLKETTRVNVSSSK- 18950
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ +L I E ED G + SN G+++
Sbjct: 18951 -------TVTSLSIKEASKEDVGTYELCVSNSAGSIT 18980
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 8/81 (9%)
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
Q ++ G + + G P+PKV W E ++++ I K R+ TL
Sbjct: 22158 QLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRT--------TLT 22209
Query: 502 IAEVFAEDSGCFTCTASNKYG 522
+ + DSG + T N G
Sbjct: 22210 VKDSMRGDSGRYFLTLENTAG 22230
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP T I G P PKV W + ++ K + + D T +L ++ + D G Y
Sbjct: 22165 GSPFTIDVPISGRPAPKVTWKLEEMRL-KETDRVSITTTKDRT-TLTVKDSMRGDSGRYF 22222
Query: 1019 IMAANPQG 1026
+ N G
Sbjct: 22223 LTLENTAG 22230
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G ++L V G PPP + W +G +L + I ++ +L L + + D G+Y+
Sbjct: 22964 GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSL--LIVDKVNRYDAGKYTIE 23021
Query: 343 ASNIYGTDSTSAEIYI 358
A N G S + + +
Sbjct: 23022 AENQSGKKSATVLVKV 23037
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/90 (24%), Positives = 39/90 (43%), Gaps = 7/90 (7%)
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQP--VLPDASHKM---LVRETGVHS--LLID 1134
+V G R+ + G P P+ +W +G+ + D H + ET +S ++I
Sbjct: 9323 LVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIP 9382
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
+ G Y A NK GQ + + + V+
Sbjct: 9383 ECKRSHTGKYSITAKNKAGQKTANCRVKVM 9412
Score = 31.2 bits (69), Expect = 6.9
Identities = 22/85 (25%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G + ++ G P P + W K+GK + R + + ++ L I+ D G
Sbjct: 11423 VRVGQTIRILARVKGRPEPDITWTKEGK-VLVREKRVDLIQDLP-RVELQIKEAVRADHG 11480
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLP 1040
Y I A N G S + V P
Sbjct: 11481 KYIISAKNSSGHAQGSAIVNVLDRP 11505
Score = 31.2 bits (69), Expect = 6.9
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 6/96 (6%)
Query: 1162 SVVAKEVKKAP-VILEKLQNCG--VPEGHPVRLEC-RVIGMPPPVFYWKKDNETIPCTRE 1217
+++ K+ +AP ++L+ G + G + L ++G P P W K + I
Sbjct: 13869 TIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDI--RPS 13926
Query: 1218 RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
I+ T + L I+ A + DAG YT++A N G
Sbjct: 13927 DITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 13962
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 6/90 (6%)
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
+RL + G P P W+K E I R +I + T+ + L+I + D+G Y L+
Sbjct: 18628 LRLFVTIKGRPEPEVKWEKA-EGILTDRAQIEV---TSSFTMLVIDNVTRFDSGRYNLTL 18683
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMSVR 1278
+N +G S TA +++ P +++R
Sbjct: 18684 ENNSG--SKTAFVNVRVLDSPSAPVNLTIR 18711
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/84 (26%), Positives = 33/84 (39%), Gaps = 6/84 (7%)
Query: 1076 LQAPGDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS---- 1130
L GD + G + V+GLP P++ W N + + +E S
Sbjct: 8904 LSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKT 8963
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTG 1153
L I + D GTY A+N+ G
Sbjct: 8964 ELSIPKAVREDKGTYTVTASNRLG 8987
Score = 30.8 bits (68), Expect = 9.0
Identities = 20/69 (28%), Positives = 27/69 (39%), Gaps = 4/69 (5%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMRREGDGTCSLHIESTTSDDDGNY 1017
G T + G P PKV WFKD + + + H K T +L D G Y
Sbjct: 10336 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTT---PATLALEKIKAKRSDSGKY 10392
Query: 1018 TIMAANPQG 1026
++ N G
Sbjct: 10393 CVVVENSTG 10401
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/79 (21%), Positives = 32/79 (40%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
E + +L + G P P V W L + + + +L + + + D G+Y+
Sbjct: 13499 ENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTI 13558
Query: 342 FASNIYGTDSTSAEIYIEG 360
N+ GT + I + G
Sbjct: 13559 TLKNVAGTKEGTISIKVVG 13577
Score = 30.8 bits (68), Expect = 9.0
Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 1096 VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL-IDPLTQRDAGTYKCIATNKTGQ 1154
+ G P P+ +W G+ + P S + T S+L I T++DAG Y ATN G
Sbjct: 13906 ILGKPLPKSSWSKAGKDIRP--SDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGT 13963
Query: 1155 NSFSLELSVVAKEVKKAPV 1173
++++V+ PV
Sbjct: 13964 KVEHVKVTVLDVPGPPGPV 13982
Score = 30.8 bits (68), Expect = 9.0
Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 12/76 (15%)
Query: 458 VKGAPSPKVEWYRE-GTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCT 516
+KG P+P+V+W R+ G ++ + S+ L++ V DSG + T
Sbjct: 15387 IKGRPAPEVKWARDHGESLDKA-----------SIESTSSYTLLIVGNVNRFDSGKYILT 15435
Query: 517 ASNKYGTVSSIAQLHV 532
N G+ S+ + V
Sbjct: 15436 VENSSGSKSAFVNVRV 15451
Score = 30.8 bits (68), Expect = 9.0
Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 8/88 (9%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE---GDGTCSLHIESTTSD 1012
V G + I G P+P + W KDG +I +R R E D L ++
Sbjct: 19304 VKAGEVLKINADIAGRPLPVISWAKDGIEIEER-----ARTEIISTDNHTLLTVKDCIRR 19358
Query: 1013 DDGNYTIMAANPQGRISCSGHLMVQSLP 1040
D G Y + N G S + + V P
Sbjct: 19359 DTGQYVLTLKNVAGTRSVAVNCKVLDKP 19386
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/77 (22%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G+++ + G P P + W ++G IE+ I+ ++ L + +
Sbjct: 19307 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTL--------LTVKDCIRR 19358
Query: 509 DSGCFTCTASNKYGTVS 525
D+G + T N GT S
Sbjct: 19359 DTGQYVLTLKNVAGTRS 19375
Score = 30.8 bits (68), Expect = 9.0
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI-VQAGNLHSLTIAEAFEEDTGR 338
V G+ +++D + G P P+V +G L+ + + + A NL ++ + E+ D GR
Sbjct: 19991 VRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENL-TINLKESVTADAGR 20049
Query: 339 YSCFASNIYGTDSTSAEIYI 358
Y A+N GT I +
Sbjct: 20050 YEITAANSSGTTKAFINIVV 20069
Score = 30.8 bits (68), Expect = 9.0
Identities = 17/60 (28%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 970 GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRIS 1029
G P P + W KDG + K +E + + + +L I++ + G YT++ N RI+
Sbjct: 21092 GKPKPSISWLKDGLPL-KESEFVRFSKT-ENKITLSIKNAKKEHGGKYTVILDNAVCRIA 21149
>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
Length = 1794
Score = 141 bits (356), Expect = 4e-33
Identities = 136/517 (26%), Positives = 195/517 (37%), Gaps = 44/517 (8%)
Query: 746 TLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGN 805
T S + + +SKES L S + KS S Q PP P P S
Sbjct: 267 TNSDVRKEVTNVISKESKLDSLEAA-AKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC 325
Query: 806 QFQPRCVSPIPV-SPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKN 864
+ PR PV TS A P P + + G R P+ P A
Sbjct: 326 KDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRP--ATFP 383
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTP 924
T+ P + D + + N I G++ D + E K S E + ++FR E
Sbjct: 384 TRQPGLGSQDVVSKAANRRIPMEGQR----DSAFPKFESKPQSQEVKENQTVKFRCEGLA 439
Query: 925 VDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQ 984
V E +AP F LK V EG C + G PVP++ W +G+
Sbjct: 440 VME---------------VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQP 484
Query: 985 ISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
I C+ G LHI+ +D G YT +A N G++SCS + V
Sbjct: 485 IQYARSTCEA-----GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHE------ 533
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPEL 1104
+ SR E + P FLQ D+ +G + +VSG PPPE+
Sbjct: 534 --------KKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEV 585
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
WL NG + R T HSL I + D GTY C A N G+ L+V
Sbjct: 586 IWLHNGNEIQESEDFHFEQRGTQ-HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ 644
Query: 1165 AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
P + K ++ G V + C + G P P +W +D + + + Q+
Sbjct: 645 EPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQN 704
Query: 1225 TTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ L+++ + AG Y + KN G SC L
Sbjct: 705 EDVFT-LVLKKVQPWHAGQYEILLKNRVGECSCQVSL 740
Score = 93.6 bits (231), Expect = 1e-18
Identities = 191/852 (22%), Positives = 300/852 (35%), Gaps = 171/852 (20%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F Q L +V +G++V + V G PPP+V W G E++ S D H Q G HSL I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI 613
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
E F EDTG Y+C A N S G+ + + +Q+P++ + P
Sbjct: 614 QEVFPEDTGTYTCEAWN--------------------SAGEVRTQAVLTVQEPHDGTQP- 652
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+++PR T AS
Sbjct: 653 --------------WFISKPRSVT---------------------------------ASL 665
Query: 449 GQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
GQ V+ C + G P P V W R+G L +D+ F +LQ E++ TLV+ +V
Sbjct: 666 GQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQN--------EDVFTLVLKKVQP 717
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHVRGN--------------EDLSNNGSLHSANSTTNL 553
+G + N+ G S L ++ + EDL G +
Sbjct: 718 WHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRY 777
Query: 554 AAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASS 613
++ +P P +E+ + GVL E R + +R E ++
Sbjct: 778 GSL--RPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQ----EVEQLDFRDL 831
Query: 614 EAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHN----- 668
V+T+ D +E P + KPK S + +++H+
Sbjct: 832 LGKKVSTKTLSEDDLKE--------IPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVD 883
Query: 669 --QVLLEQHQLQNP-----PPSSPKEFPFSMTVLNSNAPPAVTTSSK----QVKA-PSSQ 716
VL ++ + P PP P F + PA SS KA SS+
Sbjct: 884 FRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSK 943
Query: 717 TFSLARPK-YFFPSTNT-TAATVAP--SSSPVFTL----SSTPQTIQRTVSKESLLVS-H 767
S A+P P N A T+ P ++ P TL ++ P ++ SKE L
Sbjct: 944 PLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVK 1003
Query: 768 PSVQTKSPGGLSIQNEPLPPGPTEPTPPPF-----TFSIPSGNQFQPRC-VSPIPVSPTS 821
V K + NE ++ T P F + G + +C VS P +
Sbjct: 1004 NDVNCKRGHAGTTDNE--KRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATII 1061
Query: 822 RIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKN 881
N ++ L ++ + ++ P +GL K K ND E
Sbjct: 1062 WTLNGKTLKTTKFIILSQEGSLCSVSIEKALPE--DRGLYKCVAK-----NDAGQAECSC 1114
Query: 882 AVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGK 941
V D + + SS L E + +++ P ++ P
Sbjct: 1115 QVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKT---------PPKA 1165
Query: 942 CIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+ P + + +V G V K+ G W K KQI + +EH K+ +G+
Sbjct: 1166 AMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQI-QESEHMKVENSENGS 1224
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP-----------IRS---RLTS 1047
L I + + G YT++ N G +L V P IRS L+
Sbjct: 1225 -KLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSW 1283
Query: 1048 AGQSHRGRSRVQ 1059
G S+ G S VQ
Sbjct: 1284 YGSSYDGGSAVQ 1295
Score = 91.3 bits (225), Expect = 6e-18
Identities = 72/245 (29%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 928 SDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK 987
S D + D +P + AP F ++ + EG+ F ++ G P P+V W ++G+ I+
Sbjct: 18 SVDPSRVDSMPLTE--APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS 75
Query: 988 RNEH---CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
C +R GT SL I + +D G YT A N G + L V+ S
Sbjct: 76 GGRFLLDCGIR----GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG----SF 127
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERF------FRPHFLQAPGDMVAHEGRLCRLDCKVSG 1098
GQ ++ + +R P E P F G +V EG++ R CK++G
Sbjct: 128 AKQLGQPVVSKT-LGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITG 186
Query: 1099 LPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS 1158
P P++TWL P+ P A + + G+ L I + Q D G Y C+ N +G+ S S
Sbjct: 187 RPQPQVTWLKGNVPLQPSA-RVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 1159 LELSV 1163
ELS+
Sbjct: 246 AELSI 250
Score = 90.5 bits (223), Expect = 1e-17
Identities = 69/206 (33%), Positives = 86/206 (41%), Gaps = 22/206 (10%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F D EG+ L C V G P P +TWLLNGQP+ + E GV L
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI----QYARSTCEAGVAELH 500
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSV--------------VAKEVKKAPVILEKL 1178
I D GTY C+A N GQ S S ++V VA AP+ L+ L
Sbjct: 501 IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGL 560
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA-CLLIQPAK 1237
+ V +G V + +V G PPP W + I +E H + G L IQ
Sbjct: 561 SDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI---QESEDFHFEQRGTQHSLCIQEVF 617
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
D G YT A N AG V A L +
Sbjct: 618 PEDTGTYTCEAWNSAGEVRTQAVLTV 643
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/232 (28%), Positives = 91/232 (39%), Gaps = 36/232 (15%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
D PL E P F+ P ++ EG + + +V G P P++TW NGQP+ +
Sbjct: 25 DSMPLTEA---PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLL 81
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA---------- 1171
G SL+I + + D G Y C ATN +G ++EL+V K+
Sbjct: 82 DCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLG 141
Query: 1172 -------------------PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
P KL V EG R C++ G P P W K N +
Sbjct: 142 DRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL 201
Query: 1213 -PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
P R +S + G L I + D G YT N +G S +A L I
Sbjct: 202 QPSARVSVS---EKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 85.5 bits (210), Expect = 3e-16
Identities = 73/269 (27%), Positives = 101/269 (37%), Gaps = 65/269 (24%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F+ L+ V EG L C V G P P++ W G+ ++ + LH I
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH---I 501
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
+A ED G Y+C A N G S SA + + SS
Sbjct: 502 QDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRK---------------------- 539
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
S + P P KP AP+F + L +L +
Sbjct: 540 --SEYLLPVAPS----------------------------KP--TAPIFLQGLSDLKVMD 567
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G V +V G P P+V W G I++S DF Q+ + +L I EVF E
Sbjct: 568 GSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQH--------SLCIQEVFPE 619
Query: 509 DSGCFTCTASNKYGTVSSIAQLHVRGNED 537
D+G +TC A N G V + A L V+ D
Sbjct: 620 DTGTYTCEAWNSAGEVRTQAVLTVQEPHD 648
Score = 85.1 bits (209), Expect = 4e-16
Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 32/237 (13%)
Query: 937 IPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMR 995
+ K APIF + L +V +GS VT T ++ G P P+V W +G +I + + H + R
Sbjct: 546 VAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQR 605
Query: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
C I+ +D G YT A N G + L VQ + H G
Sbjct: 606 GTQHSLC---IQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ------------EPHDGT 650
Query: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
+P F+ P + A G+ + C ++G P P + WL +G+ +
Sbjct: 651 ----------------QPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCK 694
Query: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP 1172
D H +++ V +L++ + AG Y+ + N+ G+ S + L + + P
Sbjct: 695 DTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALP 751
Score = 81.6 bits (200), Expect = 4e-15
Identities = 38/97 (39%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F K ++ V EGS F CKI G P P+V WFKD + I + + H ++ + DG C
Sbjct: 1687 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSI-RESRHFQIDYDEDGNC 1745
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
SL I DDD YT A N G +C+ L+V+++
Sbjct: 1746 SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETM 1782
Score = 80.9 bits (198), Expect = 8e-15
Identities = 98/414 (23%), Positives = 153/414 (36%), Gaps = 86/414 (20%)
Query: 264 PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-- 321
PL + P F R+ + EG + + V G P PQV W+ G+ + S ++ G
Sbjct: 28 PLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI-TSGGRFLLDCGIR 86
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP 381
SL I EED G+Y+C A+N G + E+ +EG S + G P
Sbjct: 87 GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG-SFAKQLGQP----------- 134
Query: 382 NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKML 441
V S PAV + R + +C P F L
Sbjct: 135 --VVSKTLGDRFSAPAV--------ETRPSIWGECP-----------------PKFATKL 167
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ EGQ+ F C++ G P P+V W + ++ P R+ S++E + L
Sbjct: 168 GRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ--PSARV------SVSEKNGMQVLE 219
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG---------------NEDL-------- 538
I V +D G +TC N G S A+L ++G N D+
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVI 279
Query: 539 ---SNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIG 595
S SL +A + N ++ + SPP + + P + KLE + PR++ +
Sbjct: 280 SKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC---KDSPRTAPQTP 336
Query: 596 LRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEP 649
+ S + +A V P +G+ K P P P P
Sbjct: 337 VL-------QKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFP 383
Score = 79.3 bits (194), Expect = 2e-14
Identities = 136/598 (22%), Positives = 217/598 (36%), Gaps = 134/598 (22%)
Query: 7 EASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDL--- 63
E S +S +L+ S A RG EP+S C G GGG D L
Sbjct: 733 ECSCQVSLMLQNSS-ARALPRGR------EPAS--CEDLCGGGVGADGGGSDRYGSLRPG 783
Query: 64 -----SAFLSQEELDESVNLARL----------AINYDPLEKAD------ETQARKRLSP 102
+L +E+ ++ + + AI +E+ D + + K LS
Sbjct: 784 WPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSE 843
Query: 103 DQMKHSP--NLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEE 160
D +K P + F N Q +P+ SE + +KV + DF
Sbjct: 844 DDLKEIPAEQMDFRANL---------------QRQVKPKTVSE-EERKVHSPQQVDF--- 884
Query: 161 LSSLFKSHSSKRIRPR-------ACKNHKSKLESQNKVMQENSSSFSD-LSERRERSSVP 212
S L K +SK P A + +S L + K+ EN SS ++ L+ + SS P
Sbjct: 885 RSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKP 944
Query: 213 I----------PI----------------PADT-------RDNEVNHALEQQEAKRREAE 239
+ P+ PA+T + +E + ++E K+
Sbjct: 945 LSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1004
Query: 240 QAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQ 299
+ TT S E G P F QKL+ V EG ++ L C V PP
Sbjct: 1005 DVNCKRGHAGTTDNEKRS-----ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPAT 1059
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+ W GK L+ + I + Q G+L S++I +A ED G Y C A N G S ++ ++
Sbjct: 1060 IIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVD 1119
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP 419
+S++ + P S P +S +PP ++ AT+++ +P
Sbjct: 1120 DAPASEN-----------TKAPEMKSRRPKSS--LPP-------VLGTESDATVKKKPAP 1159
Query: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ II P ++ G+ V +V G W + I++S
Sbjct: 1160 KTPPKAAMPPQIIQFP------EDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESE 1213
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
++ E L I E GC+T NK G+ + L V D
Sbjct: 1214 HMKV--------ENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1263
Score = 76.3 bits (186), Expect = 2e-13
Identities = 105/449 (23%), Positives = 168/449 (37%), Gaps = 58/449 (12%)
Query: 739 PSSSPVFTLSSTPQTIQRTVSKESLLVSHP------SVQTKSPGGLSIQNEPLPPGPTEP 792
P+ F + Q +TVS+E V P SV K + E +PP +P
Sbjct: 850 PAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPP--PKP 907
Query: 793 TPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSA 852
P F + + S + ++ LS+ PS P P NA + A
Sbjct: 908 ATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNA----KPA 963
Query: 853 PSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRL 912
++ G AK ++ +P+ + E + ++ KK +DV
Sbjct: 964 ETLKPMGNAKP-AETLKPMGNAKPDENLKSASKEELKKDVKNDVN--------------- 1007
Query: 913 MNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIP 972
+R +D+E + + T AP F ++L+ V EG + C++ P
Sbjct: 1008 -------CKRGHAGTTDNEKRSESQGT----APAFKQKLQDVHVAEGKKLLLQCQVSSDP 1056
Query: 973 VPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSG 1032
+ W +GK + K + + +EG CS+ IE +D G Y +A N G+ CS
Sbjct: 1057 PATIIWTLNGKTL-KTTKFIILSQEGS-LCSVSIEKALPEDRGLYKCVAKNDAGQAECSC 1114
Query: 1033 HLMVQSLPIRSRLTSAGQ--SHRGRSRV-----QERD----KEPL----QERFFRPHFLQ 1077
+ V P S T A + S R +S + E D K+P + P +Q
Sbjct: 1115 QVTVDDAP-ASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ 1173
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
P D G L KV+G P TW + + + ++ H + L I
Sbjct: 1174 FPEDQKVRAGESVELFGKVTGTQPITCTW-MKFRKQIQESEHMKVENSENGSKLTILAAR 1232
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
Q G Y + NK G + L+VV K
Sbjct: 1233 QEHCGCYTLLVENKLGSRQAQVNLTVVDK 1261
Score = 64.3 bits (155), Expect = 7e-10
Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 7/108 (6%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F+K +++L EG F+C+++G P P+V W+++ I +S F+I +
Sbjct: 1689 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQI-------DYDE 1741
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ C+L+I++V +D +TC A N G + A+L V E+ G
Sbjct: 1742 DGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEG 1789
Score = 63.5 bits (153), Expect = 1e-09
Identities = 35/114 (30%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Query: 262 EEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI--VQ 319
EE P F++ +R EV EG+ + DC + G P P+V W+ + + + S I +
Sbjct: 1682 EEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDE 1741
Query: 320 AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
GN SL I++ +D +Y+C A N G + +AE+ +E + + EG+ +E
Sbjct: 1742 DGNC-SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE 1794
Score = 62.8 bits (151), Expect = 2e-09
Identities = 71/278 (25%), Positives = 111/278 (39%), Gaps = 49/278 (17%)
Query: 1053 RGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
RG + + +K + + P F Q D+ EG+ L C+VS PP + W LNG+
Sbjct: 1010 RGHAGTTDNEKRS-ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGK- 1067
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---VAKEVK 1169
L +L +E + S+ I+ D G YKC+A N GQ S +++V A E
Sbjct: 1068 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1127
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRV-----------IGMPPPVFYWKKD---------- 1208
KAP + + +P + V MPP + + +D
Sbjct: 1128 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1187
Query: 1209 -------NETIPCT----RERI--SMH---QDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ I CT R++I S H +++ + L I A++ G YTL +N+
Sbjct: 1188 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKL 1247
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS--RYGSLT 1288
G L + + P P + P S R SLT
Sbjct: 1248 GSRQAQVNLTVVDK-----PDPPAGTPCASDIRSSSLT 1280
Score = 58.9 bits (141), Expect = 3e-08
Identities = 50/167 (29%), Positives = 70/167 (41%), Gaps = 13/167 (7%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
LVA ++ P+ +D P+ AP F +NL EG FE RV+G P
Sbjct: 6 LVASSHISKTSLSVDPSR----VDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P+V W+R G I F +L R +LVI V ED G +TC A+N G
Sbjct: 62 PQVTWHRNGQPITSGGRF-LLDCGIRG------TFSLVIHAVHEEDRGKYTCEATNGSGA 114
Query: 524 VSSIAQLHVRGN--EDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPP 568
+L V G+ + L + + A+E +PS PP
Sbjct: 115 RQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPP 161
Score = 56.6 bits (135), Expect = 2e-07
Identities = 30/96 (31%), Positives = 45/96 (46%)
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131
+P+F + D+ EG R DCK+ G P PE+ W + Q + ++ E G SL
Sbjct: 1688 KPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSL 1747
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
+I + D Y C A N G+ + + EL V E
Sbjct: 1748 IISDVCGDDDAKYTCKAVNSLGEATCTAELIVETME 1783
Score = 53.5 bits (127), Expect = 1e-06
Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 13/127 (10%)
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
++P+ +++ Q+ +GL + AP F+ +L++ + EGQ V +C V+G P P+
Sbjct: 418 SKPQSQEVKENQTVKFRCEGLAVMEV--APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPR 475
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ W G I+ + RS E + L I + ED G +TC A N G VS
Sbjct: 476 ITWLLNGQPIQYA----------RSTCE-AGVAELHIQDALPEDHGTYTCLAENALGQVS 524
Query: 526 SIAQLHV 532
A + V
Sbjct: 525 CSAWVTV 531
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Query: 1142 GTYKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
G K +A++ + S S++ S V + + +AP + +N + EG + E RV G P
Sbjct: 2 GDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 1201 PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
P W ++ + I + R + G L+I + D G YT A N +G T
Sbjct: 62 PQVTWHRNGQPIT-SGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 1261 LDIYAQWHHQIPPPMSVRPSGSRYGS 1286
L + + Q+ P+ + G R+ +
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSA 146
Score = 52.0 bits (123), Expect = 4e-06
Identities = 33/105 (31%), Positives = 44/105 (41%), Gaps = 3/105 (2%)
Query: 940 GKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD 999
G+C P F +L V EG F+CKI G P P+V W K + + G
Sbjct: 157 GEC-PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGM 215
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
+H DD G YT + N G+ S S L +Q L +R
Sbjct: 216 QVLEIH--GVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANR 258
Score = 50.8 bits (120), Expect = 8e-06
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 1161 LSVVAKEVKKA-PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
L VA+E P + +++ V EG R +C++ G P P W KD+++I +R
Sbjct: 1677 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESR-HF 1735
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ D G L+I D YT A N G +CTA L
Sbjct: 1736 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEL 1777
Score = 50.4 bits (119), Expect = 1e-05
Identities = 33/94 (35%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC 1230
AP L++C V EG L+C V G P P W + + I R G A
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCE-----AGVAE 498
Query: 1231 LLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 1264
L IQ A D G YT A+N G VSC+A + ++
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVH 532
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 1/99 (1%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLH 324
G P F K RS G V + C + G P P V W +GK L +++ ++Q ++
Sbjct: 649 GTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVF 708
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS 363
+L + + G+Y N G S + ++ S+
Sbjct: 709 TLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 747
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 141 bits (356), Expect = 4e-33
Identities = 136/517 (26%), Positives = 195/517 (37%), Gaps = 44/517 (8%)
Query: 746 TLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGN 805
T S + + +SKES L S + KS S Q PP P P S
Sbjct: 267 TNSDVRKEVTNVISKESKLDSLEAA-AKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC 325
Query: 806 QFQPRCVSPIPV-SPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKN 864
+ PR PV TS A P P + + G R P+ P A
Sbjct: 326 KDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRP--ATFP 383
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTP 924
T+ P + D + + N I G++ D + E K S E + ++FR E
Sbjct: 384 TRQPGLGSQDVVSKAANRRIPMEGQR----DSAFPKFESKPQSQEVKENQTVKFRCEGLA 439
Query: 925 VDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQ 984
V E +AP F LK V EG C + G PVP++ W +G+
Sbjct: 440 VME---------------VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQP 484
Query: 985 ISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
I C+ G LHI+ +D G YT +A N G++SCS + V
Sbjct: 485 IQYARSTCEA-----GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHE------ 533
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPEL 1104
+ SR E + P FLQ D+ +G + +VSG PPPE+
Sbjct: 534 --------KKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEV 585
Query: 1105 TWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
WL NG + R T HSL I + D GTY C A N G+ L+V
Sbjct: 586 IWLHNGNEIQESEDFHFEQRGTQ-HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ 644
Query: 1165 AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
P + K ++ G V + C + G P P +W +D + + + Q+
Sbjct: 645 EPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQN 704
Query: 1225 TTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ L+++ + AG Y + KN G SC L
Sbjct: 705 EDVFT-LVLKKVQPWHAGQYEILLKNRVGECSCQVSL 740
Score = 93.6 bits (231), Expect = 1e-18
Identities = 191/852 (22%), Positives = 300/852 (35%), Gaps = 171/852 (20%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F Q L +V +G++V + V G PPP+V W G E++ S D H Q G HSL I
Sbjct: 554 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI 613
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
E F EDTG Y+C A N S G+ + + +Q+P++ + P
Sbjct: 614 QEVFPEDTGTYTCEAWN--------------------SAGEVRTQAVLTVQEPHDGTQP- 652
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+++PR T AS
Sbjct: 653 --------------WFISKPRSVT---------------------------------ASL 665
Query: 449 GQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
GQ V+ C + G P P V W R+G L +D+ F +LQ E++ TLV+ +V
Sbjct: 666 GQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQN--------EDVFTLVLKKVQP 717
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHVRGN--------------EDLSNNGSLHSANSTTNL 553
+G + N+ G S L ++ + EDL G +
Sbjct: 718 WHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRY 777
Query: 554 AAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASS 613
++ +P P +E+ + GVL E R + +R E ++
Sbjct: 778 GSL--RPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQ----EVEQLDFRDL 831
Query: 614 EAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHN----- 668
V+T+ D +E P + KPK S + +++H+
Sbjct: 832 LGKKVSTKTLSEDDLKE--------IPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVD 883
Query: 669 --QVLLEQHQLQNP-----PPSSPKEFPFSMTVLNSNAPPAVTTSSK----QVKA-PSSQ 716
VL ++ + P PP P F + PA SS KA SS+
Sbjct: 884 FRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSK 943
Query: 717 TFSLARPK-YFFPSTNT-TAATVAP--SSSPVFTL----SSTPQTIQRTVSKESLLVS-H 767
S A+P P N A T+ P ++ P TL ++ P ++ SKE L
Sbjct: 944 PLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVK 1003
Query: 768 PSVQTKSPGGLSIQNEPLPPGPTEPTPPPF-----TFSIPSGNQFQPRC-VSPIPVSPTS 821
V K + NE ++ T P F + G + +C VS P +
Sbjct: 1004 NDVNCKRGHAGTTDNE--KRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATII 1061
Query: 822 RIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKN 881
N ++ L ++ + ++ P +GL K K ND E
Sbjct: 1062 WTLNGKTLKTTKFIILSQEGSLCSVSIEKALPE--DRGLYKCVAK-----NDAGQAECSC 1114
Query: 882 AVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGK 941
V D + + SS L E + +++ P ++ P
Sbjct: 1115 QVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKT---------PPKA 1165
Query: 942 CIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+ P + + +V G V K+ G W K KQI + +EH K+ +G+
Sbjct: 1166 AMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQI-QESEHMKVENSENGS 1224
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP-----------IRS---RLTS 1047
L I + + G YT++ N G +L V P IRS L+
Sbjct: 1225 -KLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSW 1283
Query: 1048 AGQSHRGRSRVQ 1059
G S+ G S VQ
Sbjct: 1284 YGSSYDGGSAVQ 1295
Score = 91.3 bits (225), Expect = 6e-18
Identities = 72/245 (29%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 928 SDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK 987
S D + D +P + AP F ++ + EG+ F ++ G P P+V W ++G+ I+
Sbjct: 18 SVDPSRVDSMPLTE--APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS 75
Query: 988 RNEH---CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
C +R GT SL I + +D G YT A N G + L V+ S
Sbjct: 76 GGRFLLDCGIR----GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG----SF 127
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERF------FRPHFLQAPGDMVAHEGRLCRLDCKVSG 1098
GQ ++ + +R P E P F G +V EG++ R CK++G
Sbjct: 128 AKQLGQPVVSKT-LGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITG 186
Query: 1099 LPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS 1158
P P++TWL P+ P A + + G+ L I + Q D G Y C+ N +G+ S S
Sbjct: 187 RPQPQVTWLKGNVPLQPSA-RVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 1159 LELSV 1163
ELS+
Sbjct: 246 AELSI 250
Score = 90.5 bits (223), Expect = 1e-17
Identities = 69/206 (33%), Positives = 86/206 (41%), Gaps = 22/206 (10%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F D EG+ L C V G P P +TWLLNGQP+ + E GV L
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI----QYARSTCEAGVAELH 500
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSV--------------VAKEVKKAPVILEKL 1178
I D GTY C+A N GQ S S ++V VA AP+ L+ L
Sbjct: 501 IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGL 560
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA-CLLIQPAK 1237
+ V +G V + +V G PPP W + I +E H + G L IQ
Sbjct: 561 SDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI---QESEDFHFEQRGTQHSLCIQEVF 617
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
D G YT A N AG V A L +
Sbjct: 618 PEDTGTYTCEAWNSAGEVRTQAVLTV 643
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/232 (28%), Positives = 91/232 (39%), Gaps = 36/232 (15%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
D PL E P F+ P ++ EG + + +V G P P++TW NGQP+ +
Sbjct: 25 DSMPLTEA---PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLL 81
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA---------- 1171
G SL+I + + D G Y C ATN +G ++EL+V K+
Sbjct: 82 DCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLG 141
Query: 1172 -------------------PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
P KL V EG R C++ G P P W K N +
Sbjct: 142 DRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL 201
Query: 1213 -PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
P R +S + G L I + D G YT N +G S +A L I
Sbjct: 202 QPSARVSVS---EKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 85.5 bits (210), Expect = 3e-16
Identities = 73/269 (27%), Positives = 101/269 (37%), Gaps = 65/269 (24%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F+ L+ V EG L C V G P P++ W G+ ++ + LH I
Sbjct: 445 PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH---I 501
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
+A ED G Y+C A N G S SA + + SS
Sbjct: 502 QDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRK---------------------- 539
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
S + P P KP AP+F + L +L +
Sbjct: 540 --SEYLLPVAPS----------------------------KP--TAPIFLQGLSDLKVMD 567
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
G V +V G P P+V W G I++S DF Q+ + +L I EVF E
Sbjct: 568 GSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQH--------SLCIQEVFPE 619
Query: 509 DSGCFTCTASNKYGTVSSIAQLHVRGNED 537
D+G +TC A N G V + A L V+ D
Sbjct: 620 DTGTYTCEAWNSAGEVRTQAVLTVQEPHD 648
Score = 85.1 bits (209), Expect = 4e-16
Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 32/237 (13%)
Query: 937 IPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMR 995
+ K APIF + L +V +GS VT T ++ G P P+V W +G +I + + H + R
Sbjct: 546 VAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQR 605
Query: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
C I+ +D G YT A N G + L VQ + H G
Sbjct: 606 GTQHSLC---IQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ------------EPHDGT 650
Query: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
+P F+ P + A G+ + C ++G P P + WL +G+ +
Sbjct: 651 ----------------QPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCK 694
Query: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP 1172
D H +++ V +L++ + AG Y+ + N+ G+ S + L + + P
Sbjct: 695 DTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALP 751
Score = 81.6 bits (200), Expect = 4e-15
Identities = 38/97 (39%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F K ++ V EGS F CKI G P P+V WFKD + I + + H ++ + DG C
Sbjct: 1738 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSI-RESRHFQIDYDEDGNC 1796
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
SL I DDD YT A N G +C+ L+V+++
Sbjct: 1797 SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETM 1833
Score = 80.9 bits (198), Expect = 8e-15
Identities = 98/414 (23%), Positives = 153/414 (36%), Gaps = 86/414 (20%)
Query: 264 PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-- 321
PL + P F R+ + EG + + V G P PQV W+ G+ + S ++ G
Sbjct: 28 PLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI-TSGGRFLLDCGIR 86
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP 381
SL I EED G+Y+C A+N G + E+ +EG S + G P
Sbjct: 87 GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG-SFAKQLGQP----------- 134
Query: 382 NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKML 441
V S PAV + R + +C P F L
Sbjct: 135 --VVSKTLGDRFSAPAV--------ETRPSIWGECP-----------------PKFATKL 167
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ EGQ+ F C++ G P P+V W + ++ P R+ S++E + L
Sbjct: 168 GRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ--PSARV------SVSEKNGMQVLE 219
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG---------------NEDL-------- 538
I V +D G +TC N G S A+L ++G N D+
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVI 279
Query: 539 ---SNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIG 595
S SL +A + N ++ + SPP + + P + KLE + PR++ +
Sbjct: 280 SKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC---KDSPRTAPQTP 336
Query: 596 LRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEP 649
+ S + +A V P +G+ K P P P P
Sbjct: 337 VL-------QKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFP 383
Score = 79.3 bits (194), Expect = 2e-14
Identities = 136/598 (22%), Positives = 217/598 (36%), Gaps = 134/598 (22%)
Query: 7 EASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDL--- 63
E S +S +L+ S A RG EP+S C G GGG D L
Sbjct: 733 ECSCQVSLMLQNSS-ARALPRGR------EPAS--CEDLCGGGVGADGGGSDRYGSLRPG 783
Query: 64 -----SAFLSQEELDESVNLARL----------AINYDPLEKAD------ETQARKRLSP 102
+L +E+ ++ + + AI +E+ D + + K LS
Sbjct: 784 WPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSE 843
Query: 103 DQMKHSP--NLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEE 160
D +K P + F N Q +P+ SE + +KV + DF
Sbjct: 844 DDLKEIPAEQMDFRANL---------------QRQVKPKTVSE-EERKVHSPQQVDF--- 884
Query: 161 LSSLFKSHSSKRIRPR-------ACKNHKSKLESQNKVMQENSSSFSD-LSERRERSSVP 212
S L K +SK P A + +S L + K+ EN SS ++ L+ + SS P
Sbjct: 885 RSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKP 944
Query: 213 I----------PI----------------PADT-------RDNEVNHALEQQEAKRREAE 239
+ P+ PA+T + +E + ++E K+
Sbjct: 945 LSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1004
Query: 240 QAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQ 299
+ TT S E G P F QKL+ V EG ++ L C V PP
Sbjct: 1005 DVNCKRGHAGTTDNEKRS-----ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPAT 1059
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+ W GK L+ + I + Q G+L S++I +A ED G Y C A N G S ++ ++
Sbjct: 1060 IIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVD 1119
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP 419
+S++ + P S P +S +PP ++ AT+++ +P
Sbjct: 1120 DAPASEN-----------TKAPEMKSRRPKSS--LPP-------VLGTESDATVKKKPAP 1159
Query: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ II P ++ G+ V +V G W + I++S
Sbjct: 1160 KTPPKAAMPPQIIQFP------EDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESE 1213
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
++ E L I E GC+T NK G+ + L V D
Sbjct: 1214 HMKV--------ENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1263
Score = 76.3 bits (186), Expect = 2e-13
Identities = 105/449 (23%), Positives = 168/449 (37%), Gaps = 58/449 (12%)
Query: 739 PSSSPVFTLSSTPQTIQRTVSKESLLVSHP------SVQTKSPGGLSIQNEPLPPGPTEP 792
P+ F + Q +TVS+E V P SV K + E +PP +P
Sbjct: 850 PAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPP--PKP 907
Query: 793 TPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSA 852
P F + + S + ++ LS+ PS P P NA + A
Sbjct: 908 ATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNA----KPA 963
Query: 853 PSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRL 912
++ G AK ++ +P+ + E + ++ KK +DV
Sbjct: 964 ETLKPMGNAKP-AETLKPMGNAKPDENLKSASKEELKKDVKNDVN--------------- 1007
Query: 913 MNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIP 972
+R +D+E + + T AP F ++L+ V EG + C++ P
Sbjct: 1008 -------CKRGHAGTTDNEKRSESQGT----APAFKQKLQDVHVAEGKKLLLQCQVSSDP 1056
Query: 973 VPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSG 1032
+ W +GK + K + + +EG CS+ IE +D G Y +A N G+ CS
Sbjct: 1057 PATIIWTLNGKTL-KTTKFIILSQEGS-LCSVSIEKALPEDRGLYKCVAKNDAGQAECSC 1114
Query: 1033 HLMVQSLPIRSRLTSAGQ--SHRGRSRV-----QERD----KEPL----QERFFRPHFLQ 1077
+ V P S T A + S R +S + E D K+P + P +Q
Sbjct: 1115 QVTVDDAP-ASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ 1173
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
P D G L KV+G P TW + + + ++ H + L I
Sbjct: 1174 FPEDQKVRAGESVELFGKVTGTQPITCTW-MKFRKQIQESEHMKVENSENGSKLTILAAR 1232
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
Q G Y + NK G + L+VV K
Sbjct: 1233 QEHCGCYTLLVENKLGSRQAQVNLTVVDK 1261
Score = 64.3 bits (155), Expect = 7e-10
Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 7/108 (6%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F+K +++L EG F+C+++G P P+V W+++ I +S F+I +
Sbjct: 1740 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQI-------DYDE 1792
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ C+L+I++V +D +TC A N G + A+L V E+ G
Sbjct: 1793 DGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEG 1840
Score = 63.5 bits (153), Expect = 1e-09
Identities = 35/114 (30%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Query: 262 EEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI--VQ 319
EE P F++ +R EV EG+ + DC + G P P+V W+ + + + S I +
Sbjct: 1733 EEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDE 1792
Query: 320 AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
GN SL I++ +D +Y+C A N G + +AE+ +E + + EG+ +E
Sbjct: 1793 DGNC-SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE 1845
Score = 62.8 bits (151), Expect = 2e-09
Identities = 71/278 (25%), Positives = 111/278 (39%), Gaps = 49/278 (17%)
Query: 1053 RGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
RG + + +K + + P F Q D+ EG+ L C+VS PP + W LNG+
Sbjct: 1010 RGHAGTTDNEKRS-ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGK- 1067
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---VAKEVK 1169
L +L +E + S+ I+ D G YKC+A N GQ S +++V A E
Sbjct: 1068 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1127
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRV-----------IGMPPPVFYWKKD---------- 1208
KAP + + +P + V MPP + + +D
Sbjct: 1128 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1187
Query: 1209 -------NETIPCT----RERI--SMH---QDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ I CT R++I S H +++ + L I A++ G YTL +N+
Sbjct: 1188 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKL 1247
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS--RYGSLT 1288
G L + + P P + P S R SLT
Sbjct: 1248 GSRQAQVNLTVVDK-----PDPPAGTPCASDIRSSSLT 1280
Score = 58.9 bits (141), Expect = 3e-08
Identities = 50/167 (29%), Positives = 70/167 (41%), Gaps = 13/167 (7%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
LVA ++ P+ +D P+ AP F +NL EG FE RV+G P
Sbjct: 6 LVASSHISKTSLSVDPSR----VDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P+V W+R G I F +L R +LVI V ED G +TC A+N G
Sbjct: 62 PQVTWHRNGQPITSGGRF-LLDCGIRG------TFSLVIHAVHEEDRGKYTCEATNGSGA 114
Query: 524 VSSIAQLHVRGN--EDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPP 568
+L V G+ + L + + A+E +PS PP
Sbjct: 115 RQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPP 161
Score = 56.6 bits (135), Expect = 2e-07
Identities = 30/96 (31%), Positives = 45/96 (46%)
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131
+P+F + D+ EG R DCK+ G P PE+ W + Q + ++ E G SL
Sbjct: 1739 KPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSL 1798
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
+I + D Y C A N G+ + + EL V E
Sbjct: 1799 IISDVCGDDDAKYTCKAVNSLGEATCTAELIVETME 1834
Score = 53.5 bits (127), Expect = 1e-06
Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 13/127 (10%)
Query: 406 AQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPK 465
++P+ +++ Q+ +GL + AP F+ +L++ + EGQ V +C V+G P P+
Sbjct: 418 SKPQSQEVKENQTVKFRCEGLAVMEV--APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPR 475
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ W G I+ + RS E + L I + ED G +TC A N G VS
Sbjct: 476 ITWLLNGQPIQYA----------RSTCE-AGVAELHIQDALPEDHGTYTCLAENALGQVS 524
Query: 526 SIAQLHV 532
A + V
Sbjct: 525 CSAWVTV 531
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Query: 1142 GTYKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
G K +A++ + S S++ S V + + +AP + +N + EG + E RV G P
Sbjct: 2 GDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 1201 PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
P W ++ + I + R + G L+I + D G YT A N +G T
Sbjct: 62 PQVTWHRNGQPIT-SGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 1261 LDIYAQWHHQIPPPMSVRPSGSRYGS 1286
L + + Q+ P+ + G R+ +
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSA 146
Score = 52.0 bits (123), Expect = 4e-06
Identities = 33/105 (31%), Positives = 44/105 (41%), Gaps = 3/105 (2%)
Query: 940 GKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD 999
G+C P F +L V EG F+CKI G P P+V W K + + G
Sbjct: 157 GEC-PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGM 215
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
+H DD G YT + N G+ S S L +Q L +R
Sbjct: 216 QVLEIH--GVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANR 258
Score = 50.8 bits (120), Expect = 8e-06
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 1161 LSVVAKEVKKA-PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
L VA+E P + +++ V EG R +C++ G P P W KD+++I +R
Sbjct: 1728 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESR-HF 1786
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ D G L+I D YT A N G +CTA L
Sbjct: 1787 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEL 1828
Score = 50.4 bits (119), Expect = 1e-05
Identities = 33/94 (35%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC 1230
AP L++C V EG L+C V G P P W + + I R G A
Sbjct: 444 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCE-----AGVAE 498
Query: 1231 LLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIY 1264
L IQ A D G YT A+N G VSC+A + ++
Sbjct: 499 LHIQDALPEDHGTYTCLAENALGQVSCSAWVTVH 532
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 1/99 (1%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLH 324
G P F K RS G V + C + G P P V W +GK L +++ ++Q ++
Sbjct: 649 GTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVF 708
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS 363
+L + + G+Y N G S + ++ S+
Sbjct: 709 TLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 747
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 131 bits (330), Expect = 4e-30
Identities = 142/567 (25%), Positives = 206/567 (36%), Gaps = 75/567 (13%)
Query: 746 TLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGN 805
T S + + +SKES L S + KS S Q PP P P S
Sbjct: 267 TNSDVRKEVTNVISKESKLDSLEAA-AKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC 325
Query: 806 QFQPRCVSPIPV-SPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKN 864
+ PR PV TS A P P + + G R P+ P A
Sbjct: 326 KDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRP--ATFP 383
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFS---DVRPNQQEYKISS---FEQRLMN---- 914
T+ P + D + + N I G++ + + +P QE K + F +
Sbjct: 384 TRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKP 443
Query: 915 EIEFRLERTPV--DESDDEIQHD--------------EIPTGKC---------------- 942
E+ + LE TPV E E+ D + T C
Sbjct: 444 EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQ 503
Query: 943 --------IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKM 994
+AP F LK V EG C + G PVP++ W +G+ I C+
Sbjct: 504 VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEA 563
Query: 995 RREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRG 1054
G LHI+ +D G YT +A N G++SCS + V +
Sbjct: 564 -----GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHE--------------KK 604
Query: 1055 RSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL 1114
SR E + P FLQ D+ +G + +VSG PPPE+ WL NG +
Sbjct: 605 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 664
Query: 1115 PDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI 1174
R T HSL I + D GTY C A N G+ L+V P
Sbjct: 665 ESEDFHFEQRGTQ-HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWF 723
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
+ K ++ G V + C + G P P +W +D + + + Q+ + L+++
Sbjct: 724 ISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFT-LVLK 782
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ AG Y + KN G SC L
Sbjct: 783 KVQPWHAGQYEILLKNRVGECSCQVSL 809
Score = 129 bits (324), Expect = 2e-29
Identities = 102/334 (30%), Positives = 137/334 (41%), Gaps = 50/334 (14%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F+ + + V E V F C++ GIP P+V WF +G + +R E E G+ L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPV-RRQEGSIEVYEDAGSHYL 472
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ + D G Y+ A+N QG++SCS L V+ L +
Sbjct: 473 CLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVME--------------------- 511
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P F D EG+ L C V G P P +TWLLNGQP+ +
Sbjct: 512 ------VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI----QYARSTC 561
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV--------------VAKEVKK 1170
E GV L I D GTY C+A N GQ S S ++V VA
Sbjct: 562 EAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPT 621
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA- 1229
AP+ L+ L + V +G V + +V G PPP W + I +E H + G
Sbjct: 622 APIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI---QESEDFHFEQRGTQH 678
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L IQ D G YT A N AG V A L +
Sbjct: 679 SLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV 712
Score = 104 bits (259), Expect = 6e-22
Identities = 67/193 (34%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F P E + + C+VSG+P PE+ W L G PV + + G H L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK-APVILEKLQNCGVPEGHPVRL 1191
+ RD+GTY C A+N GQ S S L V V + AP L++C V EG L
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+C V G P P W + + I R G A L IQ A D G YT A+N
Sbjct: 534 QCSVRGTPVPRITWLLNGQPIQYARSTCE-----AGVAELHIQDALPEDHGTYTCLAENA 588
Query: 1252 AGIVSCTARLDIY 1264
G VSC+A + ++
Sbjct: 589 LGQVSCSAWVTVH 601
Score = 93.6 bits (231), Expect = 1e-18
Identities = 191/852 (22%), Positives = 300/852 (35%), Gaps = 171/852 (20%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F Q L +V +G++V + V G PPP+V W G E++ S D H Q G HSL I
Sbjct: 623 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI 682
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
E F EDTG Y+C A N S G+ + + +Q+P++ + P
Sbjct: 683 QEVFPEDTGTYTCEAWN--------------------SAGEVRTQAVLTVQEPHDGTQP- 721
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+++PR T AS
Sbjct: 722 --------------WFISKPRSVT---------------------------------ASL 734
Query: 449 GQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
GQ V+ C + G P P V W R+G L +D+ F +LQ E++ TLV+ +V
Sbjct: 735 GQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQN--------EDVFTLVLKKVQP 786
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHVRGN--------------EDLSNNGSLHSANSTTNL 553
+G + N+ G S L ++ + EDL G +
Sbjct: 787 WHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRY 846
Query: 554 AAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASS 613
++ +P P +E+ + GVL E R + +R E ++
Sbjct: 847 GSL--RPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQ----EVEQLDFRDL 900
Query: 614 EAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHN----- 668
V+T+ D +E P + KPK S + +++H+
Sbjct: 901 LGKKVSTKTLSEDDLKE--------IPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVD 952
Query: 669 --QVLLEQHQLQNP-----PPSSPKEFPFSMTVLNSNAPPAVTTSSK----QVKA-PSSQ 716
VL ++ + P PP P F + PA SS KA SS+
Sbjct: 953 FRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSK 1012
Query: 717 TFSLARPK-YFFPSTNT-TAATVAP--SSSPVFTL----SSTPQTIQRTVSKESLLVS-H 767
S A+P P N A T+ P ++ P TL ++ P ++ SKE L
Sbjct: 1013 PLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVK 1072
Query: 768 PSVQTKSPGGLSIQNEPLPPGPTEPTPPPF-----TFSIPSGNQFQPRC-VSPIPVSPTS 821
V K + NE ++ T P F + G + +C VS P +
Sbjct: 1073 NDVNCKRGHAGTTDNE--KRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATII 1130
Query: 822 RIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKN 881
N ++ L ++ + ++ P +GL K K ND E
Sbjct: 1131 WTLNGKTLKTTKFIILSQEGSLCSVSIEKALPE--DRGLYKCVAK-----NDAGQAECSC 1183
Query: 882 AVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGK 941
V D + + SS L E + +++ P ++ P
Sbjct: 1184 QVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKT---------PPKA 1234
Query: 942 CIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+ P + + +V G V K+ G W K KQI + +EH K+ +G+
Sbjct: 1235 AMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQI-QESEHMKVENSENGS 1293
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP-----------IRS---RLTS 1047
L I + + G YT++ N G +L V P IRS L+
Sbjct: 1294 -KLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSW 1352
Query: 1048 AGQSHRGRSRVQ 1059
G S+ G S VQ
Sbjct: 1353 YGSSYDGGSAVQ 1364
Score = 92.4 bits (228), Expect = 3e-18
Identities = 104/447 (23%), Positives = 163/447 (36%), Gaps = 102/447 (22%)
Query: 95 QARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKR----PQYCSETQSKKVF 150
+ RKR +P + P +P + S +++ P E +R P++ S+ QS++V
Sbjct: 369 EERKRPAPPRPATFPTR--QPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVK 426
Query: 151 LNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSS 210
N+ F E+S + K + + + + +E V ++ S + L + R R S
Sbjct: 427 ENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIE----VYEDAGSHYLCLLKARTRDS 482
Query: 211 VPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPR 270
A +++ + Q + E A P
Sbjct: 483 GTYSCTASNAQGQLSCSWTLQVERLAVMEVA---------------------------PS 515
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
F+ L+ V EG L C V G P P++ W G+ ++ + LH I +
Sbjct: 516 FSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH---IQD 572
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
A ED G Y+C A N G S SA + + SS
Sbjct: 573 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRK------------------------ 608
Query: 391 SAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQ 450
S + P P KP AP+F + L +L +G
Sbjct: 609 SEYLLPVAPS----------------------------KP--TAPIFLQGLSDLKVMDGS 638
Query: 451 LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDS 510
V +V G P P+V W G I++S DF Q+ + +L I EVF ED+
Sbjct: 639 QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQH--------SLCIQEVFPEDT 690
Query: 511 GCFTCTASNKYGTVSSIAQLHVRGNED 537
G +TC A N G V + A L V+ D
Sbjct: 691 GTYTCEAWNSAGEVRTQAVLTVQEPHD 717
Score = 91.3 bits (225), Expect = 6e-18
Identities = 72/245 (29%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 928 SDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK 987
S D + D +P + AP F ++ + EG+ F ++ G P P+V W ++G+ I+
Sbjct: 18 SVDPSRVDSMPLTE--APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS 75
Query: 988 RNEH---CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
C +R GT SL I + +D G YT A N G + L V+ S
Sbjct: 76 GGRFLLDCGIR----GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG----SF 127
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERF------FRPHFLQAPGDMVAHEGRLCRLDCKVSG 1098
GQ ++ + +R P E P F G +V EG++ R CK++G
Sbjct: 128 AKQLGQPVVSKT-LGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITG 186
Query: 1099 LPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS 1158
P P++TWL P+ P A + + G+ L I + Q D G Y C+ N +G+ S S
Sbjct: 187 RPQPQVTWLKGNVPLQPSA-RVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 1159 LELSV 1163
ELS+
Sbjct: 246 AELSI 250
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/232 (28%), Positives = 91/232 (39%), Gaps = 36/232 (15%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
D PL E P F+ P ++ EG + + +V G P P++TW NGQP+ +
Sbjct: 25 DSMPLTEA---PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLL 81
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA---------- 1171
G SL+I + + D G Y C ATN +G ++EL+V K+
Sbjct: 82 DCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLG 141
Query: 1172 -------------------PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
P KL V EG R C++ G P P W K N +
Sbjct: 142 DRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL 201
Query: 1213 -PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
P R +S + G L I + D G YT N +G S +A L I
Sbjct: 202 QPSARVSVS---EKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 85.1 bits (209), Expect = 4e-16
Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 32/237 (13%)
Query: 937 IPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMR 995
+ K APIF + L +V +GS VT T ++ G P P+V W +G +I + + H + R
Sbjct: 615 VAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQR 674
Query: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
C I+ +D G YT A N G + L VQ + H G
Sbjct: 675 GTQHSLC---IQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ------------EPHDGT 719
Query: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
+P F+ P + A G+ + C ++G P P + WL +G+ +
Sbjct: 720 ----------------QPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCK 763
Query: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP 1172
D H +++ V +L++ + AG Y+ + N+ G+ S + L + + P
Sbjct: 764 DTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALP 820
Score = 81.6 bits (200), Expect = 4e-15
Identities = 38/97 (39%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F K ++ V EGS F CKI G P P+V WFKD + I + + H ++ + DG C
Sbjct: 1756 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSI-RESRHFQIDYDEDGNC 1814
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
SL I DDD YT A N G +C+ L+V+++
Sbjct: 1815 SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETM 1851
Score = 80.9 bits (198), Expect = 8e-15
Identities = 98/414 (23%), Positives = 153/414 (36%), Gaps = 86/414 (20%)
Query: 264 PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-- 321
PL + P F R+ + EG + + V G P PQV W+ G+ + S ++ G
Sbjct: 28 PLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI-TSGGRFLLDCGIR 86
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP 381
SL I EED G+Y+C A+N G + E+ +EG S + G P
Sbjct: 87 GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG-SFAKQLGQP----------- 134
Query: 382 NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKML 441
V S PAV + R + +C P F L
Sbjct: 135 --VVSKTLGDRFSAPAV--------ETRPSIWGECP-----------------PKFATKL 167
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ EGQ+ F C++ G P P+V W + ++ P R+ S++E + L
Sbjct: 168 GRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ--PSARV------SVSEKNGMQVLE 219
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG---------------NEDL-------- 538
I V +D G +TC N G S A+L ++G N D+
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVI 279
Query: 539 ---SNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIG 595
S SL +A + N ++ + SPP + + P + KLE + PR++ +
Sbjct: 280 SKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC---KDSPRTAPQTP 336
Query: 596 LRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEP 649
+ S + +A V P +G+ K P P P P
Sbjct: 337 VL-------QKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFP 383
Score = 79.3 bits (194), Expect = 2e-14
Identities = 136/598 (22%), Positives = 217/598 (36%), Gaps = 134/598 (22%)
Query: 7 EASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDL--- 63
E S +S +L+ S A RG EP+S C G GGG D L
Sbjct: 802 ECSCQVSLMLQNSS-ARALPRGR------EPAS--CEDLCGGGVGADGGGSDRYGSLRPG 852
Query: 64 -----SAFLSQEELDESVNLARL----------AINYDPLEKAD------ETQARKRLSP 102
+L +E+ ++ + + AI +E+ D + + K LS
Sbjct: 853 WPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSE 912
Query: 103 DQMKHSP--NLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEE 160
D +K P + F N Q +P+ SE + +KV + DF
Sbjct: 913 DDLKEIPAEQMDFRANL---------------QRQVKPKTVSE-EERKVHSPQQVDF--- 953
Query: 161 LSSLFKSHSSKRIRPR-------ACKNHKSKLESQNKVMQENSSSFSD-LSERRERSSVP 212
S L K +SK P A + +S L + K+ EN SS ++ L+ + SS P
Sbjct: 954 RSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKP 1013
Query: 213 I----------PI----------------PADT-------RDNEVNHALEQQEAKRREAE 239
+ P+ PA+T + +E + ++E K+
Sbjct: 1014 LSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1073
Query: 240 QAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQ 299
+ TT S E G P F QKL+ V EG ++ L C V PP
Sbjct: 1074 DVNCKRGHAGTTDNEKRS-----ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPAT 1128
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+ W GK L+ + I + Q G+L S++I +A ED G Y C A N G S ++ ++
Sbjct: 1129 IIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVD 1188
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP 419
+S++ + P S P +S +PP ++ AT+++ +P
Sbjct: 1189 DAPASEN-----------TKAPEMKSRRPKSS--LPP-------VLGTESDATVKKKPAP 1228
Query: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ II P ++ G+ V +V G W + I++S
Sbjct: 1229 KTPPKAAMPPQIIQFP------EDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESE 1282
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
++ E L I E GC+T NK G+ + L V D
Sbjct: 1283 HMKV--------ENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1332
Score = 76.3 bits (186), Expect = 2e-13
Identities = 105/449 (23%), Positives = 168/449 (37%), Gaps = 58/449 (12%)
Query: 739 PSSSPVFTLSSTPQTIQRTVSKESLLVSHP------SVQTKSPGGLSIQNEPLPPGPTEP 792
P+ F + Q +TVS+E V P SV K + E +PP +P
Sbjct: 919 PAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPP--PKP 976
Query: 793 TPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSA 852
P F + + S + ++ LS+ PS P P NA + A
Sbjct: 977 ATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNA----KPA 1032
Query: 853 PSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRL 912
++ G AK ++ +P+ + E + ++ KK +DV
Sbjct: 1033 ETLKPMGNAKP-AETLKPMGNAKPDENLKSASKEELKKDVKNDVN--------------- 1076
Query: 913 MNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIP 972
+R +D+E + + T AP F ++L+ V EG + C++ P
Sbjct: 1077 -------CKRGHAGTTDNEKRSESQGT----APAFKQKLQDVHVAEGKKLLLQCQVSSDP 1125
Query: 973 VPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSG 1032
+ W +GK + K + + +EG CS+ IE +D G Y +A N G+ CS
Sbjct: 1126 PATIIWTLNGKTL-KTTKFIILSQEGS-LCSVSIEKALPEDRGLYKCVAKNDAGQAECSC 1183
Query: 1033 HLMVQSLPIRSRLTSAGQ--SHRGRSRV-----QERD----KEPL----QERFFRPHFLQ 1077
+ V P S T A + S R +S + E D K+P + P +Q
Sbjct: 1184 QVTVDDAP-ASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ 1242
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
P D G L KV+G P TW + + + ++ H + L I
Sbjct: 1243 FPEDQKVRAGESVELFGKVTGTQPITCTW-MKFRKQIQESEHMKVENSENGSKLTILAAR 1301
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
Q G Y + NK G + L+VV K
Sbjct: 1302 QEHCGCYTLLVENKLGSRQAQVNLTVVDK 1330
Score = 65.9 bits (159), Expect = 3e-10
Identities = 85/382 (22%), Positives = 134/382 (35%), Gaps = 66/382 (17%)
Query: 940 GKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD 999
G+C P F +L V EG F+CKI G P P+V W K + + G
Sbjct: 157 GEC-PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGM 215
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+H DD G YT + N G+ S S L +Q G RS V+
Sbjct: 216 QVLEIH--GVNQDDVGVYTCLVVNGSGKASMSAELSIQ-----------GLDSANRSFVR 262
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDC---KVSGLPPPELTWLLNGQPVLPD 1116
E R + + + + E +C + G PP W N QP P
Sbjct: 263 ETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPP----WAANSQPQPPR 318
Query: 1117 ASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN-KTGQNSFSLELSVVAKEVKKAPV-- 1173
S K+ + + P+ Q+ + + A + + L + + E +K P
Sbjct: 319 ES-KLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPP 377
Query: 1174 ----------------ILEKLQNCGVP----------------------EGHPVRLECRV 1195
++ K N +P E V+ C V
Sbjct: 378 RPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEV 437
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDT-TGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G+P P W + + I +++D + Y CLL A+ D+G Y+ +A N G
Sbjct: 438 SGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLL--KARTRDSGTYSCTASNAQGQ 495
Query: 1255 VSCTARLDIYAQWHHQIPPPMS 1276
+SC+ L + ++ P S
Sbjct: 496 LSCSWTLQVERLAVMEVAPSFS 517
Score = 64.3 bits (155), Expect = 7e-10
Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 7/108 (6%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F+K +++L EG F+C+++G P P+V W+++ I +S F+I +
Sbjct: 1758 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQI-------DYDE 1810
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ C+L+I++V +D +TC A N G + A+L V E+ G
Sbjct: 1811 DGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEG 1858
Score = 63.5 bits (153), Expect = 1e-09
Identities = 35/114 (30%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Query: 262 EEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI--VQ 319
EE P F++ +R EV EG+ + DC + G P P+V W+ + + + S I +
Sbjct: 1751 EEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDE 1810
Query: 320 AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
GN SL I++ +D +Y+C A N G + +AE+ +E + + EG+ +E
Sbjct: 1811 DGNC-SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE 1863
Score = 62.8 bits (151), Expect = 2e-09
Identities = 71/278 (25%), Positives = 111/278 (39%), Gaps = 49/278 (17%)
Query: 1053 RGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
RG + + +K + + P F Q D+ EG+ L C+VS PP + W LNG+
Sbjct: 1079 RGHAGTTDNEKRS-ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGK- 1136
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---VAKEVK 1169
L +L +E + S+ I+ D G YKC+A N GQ S +++V A E
Sbjct: 1137 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1196
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRV-----------IGMPPPVFYWKKD---------- 1208
KAP + + +P + V MPP + + +D
Sbjct: 1197 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1256
Query: 1209 -------NETIPCT----RERI--SMH---QDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ I CT R++I S H +++ + L I A++ G YTL +N+
Sbjct: 1257 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKL 1316
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS--RYGSLT 1288
G L + + P P + P S R SLT
Sbjct: 1317 GSRQAQVNLTVVDK-----PDPPAGTPCASDIRSSSLT 1349
Score = 60.8 bits (146), Expect = 8e-09
Identities = 74/295 (25%), Positives = 115/295 (38%), Gaps = 24/295 (8%)
Query: 396 PAVPQ-AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
PA P+ A QP + + N ++G+ A P F Q+ E Q V F
Sbjct: 374 PAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKF 433
Query: 455 ECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFT 514
C V G P P+V W+ EGT + Q+ + E L + + DSG ++
Sbjct: 434 RCEVSGIPKPEVAWFLEGTPVR-------RQEGSIEVYEDAGSHYLCLLKARTRDSGTYS 486
Query: 515 CTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
CTASN G +S L V + S S + A IE Q SV P
Sbjct: 487 CTASNAQGQLSCSWTLQVERLAVMEVAPSFSSV--LKDCAVIEGQDFVLQC---SVRGTP 541
Query: 575 KPKLEGVLVNHNEP----RSSSRIG---LRVHFNLPEDDKGSEASSEAGVVTTRQTRPDS 627
P++ +L + +P RS+ G L + LPED +E + + +
Sbjct: 542 VPRITWLL--NGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVT 599
Query: 628 FQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPP 682
E+ + + ++ P +P K P+ + D + +QV + NPPP
Sbjct: 600 VHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMD--GSQVTMTVQVSGNPPP 652
Score = 58.9 bits (141), Expect = 3e-08
Identities = 50/167 (29%), Positives = 70/167 (41%), Gaps = 13/167 (7%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
LVA ++ P+ +D P+ AP F +NL EG FE RV+G P
Sbjct: 6 LVASSHISKTSLSVDPSR----VDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P+V W+R G I F +L R +LVI V ED G +TC A+N G
Sbjct: 62 PQVTWHRNGQPITSGGRF-LLDCGIRG------TFSLVIHAVHEEDRGKYTCEATNGSGA 114
Query: 524 VSSIAQLHVRGN--EDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPP 568
+L V G+ + L + + A+E +PS PP
Sbjct: 115 RQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPP 161
Score = 56.6 bits (135), Expect = 2e-07
Identities = 30/96 (31%), Positives = 45/96 (46%)
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131
+P+F + D+ EG R DCK+ G P PE+ W + Q + ++ E G SL
Sbjct: 1757 KPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSL 1816
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
+I + D Y C A N G+ + + EL V E
Sbjct: 1817 IISDVCGDDDAKYTCKAVNSLGEATCTAELIVETME 1852
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Query: 1142 GTYKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
G K +A++ + S S++ S V + + +AP + +N + EG + E RV G P
Sbjct: 2 GDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 1201 PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
P W ++ + I + R + G L+I + D G YT A N +G T
Sbjct: 62 PQVTWHRNGQPIT-SGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 1261 LDIYAQWHHQIPPPMSVRPSGSRYGS 1286
L + + Q+ P+ + G R+ +
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSA 146
Score = 50.8 bits (120), Expect = 8e-06
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 1161 LSVVAKEVKKA-PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
L VA+E P + +++ V EG R +C++ G P P W KD+++I +R
Sbjct: 1746 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESR-HF 1804
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ D G L+I D YT A N G +CTA L
Sbjct: 1805 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEL 1846
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 1/99 (1%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLH 324
G P F K RS G V + C + G P P V W +GK L +++ ++Q ++
Sbjct: 718 GTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVF 777
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS 363
+L + + G+Y N G S + ++ S+
Sbjct: 778 TLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 816
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 131 bits (330), Expect = 4e-30
Identities = 142/567 (25%), Positives = 206/567 (36%), Gaps = 75/567 (13%)
Query: 746 TLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGN 805
T S + + +SKES L S + KS S Q PP P P S
Sbjct: 267 TNSDVRKEVTNVISKESKLDSLEAA-AKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC 325
Query: 806 QFQPRCVSPIPV-SPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKN 864
+ PR PV TS A P P + + G R P+ P A
Sbjct: 326 KDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRP--ATFP 383
Query: 865 TKSPQPVNDDNIRETKNAVIRDLGKKITFS---DVRPNQQEYKISS---FEQRLMN---- 914
T+ P + D + + N I G++ + + +P QE K + F +
Sbjct: 384 TRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKP 443
Query: 915 EIEFRLERTPV--DESDDEIQHD--------------EIPTGKC---------------- 942
E+ + LE TPV E E+ D + T C
Sbjct: 444 EVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQ 503
Query: 943 --------IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKM 994
+AP F LK V EG C + G PVP++ W +G+ I C+
Sbjct: 504 VERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEA 563
Query: 995 RREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRG 1054
G LHI+ +D G YT +A N G++SCS + V +
Sbjct: 564 -----GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHE--------------KK 604
Query: 1055 RSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL 1114
SR E + P FLQ D+ +G + +VSG PPPE+ WL NG +
Sbjct: 605 SSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQ 664
Query: 1115 PDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI 1174
R T HSL I + D GTY C A N G+ L+V P
Sbjct: 665 ESEDFHFEQRGTQ-HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWF 723
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
+ K ++ G V + C + G P P +W +D + + + Q+ + L+++
Sbjct: 724 ISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFT-LVLK 782
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ AG Y + KN G SC L
Sbjct: 783 KVQPWHAGQYEILLKNRVGECSCQVSL 809
Score = 129 bits (324), Expect = 2e-29
Identities = 102/334 (30%), Positives = 137/334 (41%), Gaps = 50/334 (14%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F+ + + V E V F C++ GIP P+V WF +G + +R E E G+ L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPV-RRQEGSIEVYEDAGSHYL 472
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
+ + D G Y+ A+N QG++SCS L V+ L +
Sbjct: 473 CLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVME--------------------- 511
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P F D EG+ L C V G P P +TWLLNGQP+ +
Sbjct: 512 ------VAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI----QYARSTC 561
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV--------------VAKEVKK 1170
E GV L I D GTY C+A N GQ S S ++V VA
Sbjct: 562 EAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPT 621
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYA- 1229
AP+ L+ L + V +G V + +V G PPP W + I +E H + G
Sbjct: 622 APIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI---QESEDFHFEQRGTQH 678
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L IQ D G YT A N AG V A L +
Sbjct: 679 SLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTV 712
Score = 104 bits (259), Expect = 6e-22
Identities = 67/193 (34%), Positives = 88/193 (45%), Gaps = 6/193 (3%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F P E + + C+VSG+P PE+ W L G PV + + G H L
Sbjct: 414 PKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLC 473
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKK-APVILEKLQNCGVPEGHPVRL 1191
+ RD+GTY C A+N GQ S S L V V + AP L++C V EG L
Sbjct: 474 LLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVL 533
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+C V G P P W + + I R G A L IQ A D G YT A+N
Sbjct: 534 QCSVRGTPVPRITWLLNGQPIQYARSTCE-----AGVAELHIQDALPEDHGTYTCLAENA 588
Query: 1252 AGIVSCTARLDIY 1264
G VSC+A + ++
Sbjct: 589 LGQVSCSAWVTVH 601
Score = 93.6 bits (231), Expect = 1e-18
Identities = 191/852 (22%), Positives = 300/852 (35%), Gaps = 171/852 (20%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F Q L +V +G++V + V G PPP+V W G E++ S D H Q G HSL I
Sbjct: 623 PIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCI 682
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
E F EDTG Y+C A N S G+ + + +Q+P++ + P
Sbjct: 683 QEVFPEDTGTYTCEAWN--------------------SAGEVRTQAVLTVQEPHDGTQP- 721
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
+++PR T AS
Sbjct: 722 --------------WFISKPRSVT---------------------------------ASL 734
Query: 449 GQLVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
GQ V+ C + G P P V W R+G L +D+ F +LQ E++ TLV+ +V
Sbjct: 735 GQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQN--------EDVFTLVLKKVQP 786
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHVRGN--------------EDLSNNGSLHSANSTTNL 553
+G + N+ G S L ++ + EDL G +
Sbjct: 787 WHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRY 846
Query: 554 AAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASS 613
++ +P P +E+ + GVL E R + +R E ++
Sbjct: 847 GSL--RPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQ----EVEQLDFRDL 900
Query: 614 EAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHN----- 668
V+T+ D +E P + KPK S + +++H+
Sbjct: 901 LGKKVSTKTLSEDDLKE--------IPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVD 952
Query: 669 --QVLLEQHQLQNP-----PPSSPKEFPFSMTVLNSNAPPAVTTSSK----QVKA-PSSQ 716
VL ++ + P PP P F + PA SS KA SS+
Sbjct: 953 FRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSK 1012
Query: 717 TFSLARPK-YFFPSTNT-TAATVAP--SSSPVFTL----SSTPQTIQRTVSKESLLVS-H 767
S A+P P N A T+ P ++ P TL ++ P ++ SKE L
Sbjct: 1013 PLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVK 1072
Query: 768 PSVQTKSPGGLSIQNEPLPPGPTEPTPPPF-----TFSIPSGNQFQPRC-VSPIPVSPTS 821
V K + NE ++ T P F + G + +C VS P +
Sbjct: 1073 NDVNCKRGHAGTTDNE--KRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATII 1130
Query: 822 RIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKN 881
N ++ L ++ + ++ P +GL K K ND E
Sbjct: 1131 WTLNGKTLKTTKFIILSQEGSLCSVSIEKALPE--DRGLYKCVAK-----NDAGQAECSC 1183
Query: 882 AVIRDLGKKITFSDVRPNQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGK 941
V D + + SS L E + +++ P ++ P
Sbjct: 1184 QVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKT---------PPKA 1234
Query: 942 CIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+ P + + +V G V K+ G W K KQI + +EH K+ +G+
Sbjct: 1235 AMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQI-QESEHMKVENSENGS 1293
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP-----------IRS---RLTS 1047
L I + + G YT++ N G +L V P IRS L+
Sbjct: 1294 -KLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSW 1352
Query: 1048 AGQSHRGRSRVQ 1059
G S+ G S VQ
Sbjct: 1353 YGSSYDGGSAVQ 1364
Score = 92.4 bits (228), Expect = 3e-18
Identities = 104/447 (23%), Positives = 163/447 (36%), Gaps = 102/447 (22%)
Query: 95 QARKRLSPDQMKHSPNLSFEPNFCQDNPRSPTSSKESPQEAKR----PQYCSETQSKKVF 150
+ RKR +P + P +P + S +++ P E +R P++ S+ QS++V
Sbjct: 369 EERKRPAPPRPATFPTR--QPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVK 426
Query: 151 LNKAADFIEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSS 210
N+ F E+S + K + + + + +E V ++ S + L + R R S
Sbjct: 427 ENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIE----VYEDAGSHYLCLLKARTRDS 482
Query: 211 VPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPR 270
A +++ + Q + E A P
Sbjct: 483 GTYSCTASNAQGQLSCSWTLQVERLAVMEVA---------------------------PS 515
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
F+ L+ V EG L C V G P P++ W G+ ++ + LH I +
Sbjct: 516 FSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELH---IQD 572
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
A ED G Y+C A N G S SA + + SS
Sbjct: 573 ALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRK------------------------ 608
Query: 391 SAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQ 450
S + P P KP AP+F + L +L +G
Sbjct: 609 SEYLLPVAPS----------------------------KP--TAPIFLQGLSDLKVMDGS 638
Query: 451 LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDS 510
V +V G P P+V W G I++S DF Q+ + +L I EVF ED+
Sbjct: 639 QVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQH--------SLCIQEVFPEDT 690
Query: 511 GCFTCTASNKYGTVSSIAQLHVRGNED 537
G +TC A N G V + A L V+ D
Sbjct: 691 GTYTCEAWNSAGEVRTQAVLTVQEPHD 717
Score = 91.3 bits (225), Expect = 6e-18
Identities = 72/245 (29%), Positives = 111/245 (45%), Gaps = 21/245 (8%)
Query: 928 SDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK 987
S D + D +P + AP F ++ + EG+ F ++ G P P+V W ++G+ I+
Sbjct: 18 SVDPSRVDSMPLTE--APAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITS 75
Query: 988 RNEH---CKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR 1044
C +R GT SL I + +D G YT A N G + L V+ S
Sbjct: 76 GGRFLLDCGIR----GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG----SF 127
Query: 1045 LTSAGQSHRGRSRVQERDKEPLQERF------FRPHFLQAPGDMVAHEGRLCRLDCKVSG 1098
GQ ++ + +R P E P F G +V EG++ R CK++G
Sbjct: 128 AKQLGQPVVSKT-LGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITG 186
Query: 1099 LPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFS 1158
P P++TWL P+ P A + + G+ L I + Q D G Y C+ N +G+ S S
Sbjct: 187 RPQPQVTWLKGNVPLQPSA-RVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Query: 1159 LELSV 1163
ELS+
Sbjct: 246 AELSI 250
Score = 85.9 bits (211), Expect = 2e-16
Identities = 65/232 (28%), Positives = 91/232 (39%), Gaps = 36/232 (15%)
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
D PL E P F+ P ++ EG + + +V G P P++TW NGQP+ +
Sbjct: 25 DSMPLTEA---PAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLL 81
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA---------- 1171
G SL+I + + D G Y C ATN +G ++EL+V K+
Sbjct: 82 DCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLG 141
Query: 1172 -------------------PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETI 1212
P KL V EG R C++ G P P W K N +
Sbjct: 142 DRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPL 201
Query: 1213 -PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
P R +S + G L I + D G YT N +G S +A L I
Sbjct: 202 QPSARVSVS---EKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI 250
Score = 85.1 bits (209), Expect = 4e-16
Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 32/237 (13%)
Query: 937 IPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNE-HCKMR 995
+ K APIF + L +V +GS VT T ++ G P P+V W +G +I + + H + R
Sbjct: 615 VAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQR 674
Query: 996 REGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR 1055
C I+ +D G YT A N G + L VQ + H G
Sbjct: 675 GTQHSLC---IQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ------------EPHDGT 719
Query: 1056 SRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
+P F+ P + A G+ + C ++G P P + WL +G+ +
Sbjct: 720 ----------------QPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCK 763
Query: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP 1172
D H +++ V +L++ + AG Y+ + N+ G+ S + L + + P
Sbjct: 764 DTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALP 820
Score = 81.6 bits (200), Expect = 4e-15
Identities = 38/97 (39%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F K ++ V EGS F CKI G P P+V WFKD + I + + H ++ + DG C
Sbjct: 1807 VKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSI-RESRHFQIDYDEDGNC 1865
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL 1039
SL I DDD YT A N G +C+ L+V+++
Sbjct: 1866 SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETM 1902
Score = 80.9 bits (198), Expect = 8e-15
Identities = 98/414 (23%), Positives = 153/414 (36%), Gaps = 86/414 (20%)
Query: 264 PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-- 321
PL + P F R+ + EG + + V G P PQV W+ G+ + S ++ G
Sbjct: 28 PLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPI-TSGGRFLLDCGIR 86
Query: 322 NLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP 381
SL I EED G+Y+C A+N G + E+ +EG S + G P
Sbjct: 87 GTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEG-SFAKQLGQP----------- 134
Query: 382 NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKML 441
V S PAV + R + +C P F L
Sbjct: 135 --VVSKTLGDRFSAPAV--------ETRPSIWGECP-----------------PKFATKL 167
Query: 442 QNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
+ EGQ+ F C++ G P P+V W + ++ P R+ S++E + L
Sbjct: 168 GRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ--PSARV------SVSEKNGMQVLE 219
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG---------------NEDL-------- 538
I V +D G +TC N G S A+L ++G N D+
Sbjct: 220 IHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVI 279
Query: 539 ---SNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIG 595
S SL +A + N ++ + SPP + + P + KLE + PR++ +
Sbjct: 280 SKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESC---KDSPRTAPQTP 336
Query: 596 LRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEP 649
+ S + +A V P +G+ K P P P P
Sbjct: 337 VL-------QKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFP 383
Score = 79.3 bits (194), Expect = 2e-14
Identities = 136/598 (22%), Positives = 217/598 (36%), Gaps = 134/598 (22%)
Query: 7 EASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDLPDL--- 63
E S +S +L+ S A RG EP+S C G GGG D L
Sbjct: 802 ECSCQVSLMLQNSS-ARALPRGR------EPAS--CEDLCGGGVGADGGGSDRYGSLRPG 852
Query: 64 -----SAFLSQEELDESVNLARL----------AINYDPLEKAD------ETQARKRLSP 102
+L +E+ ++ + + AI +E+ D + + K LS
Sbjct: 853 WPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSE 912
Query: 103 DQMKHSP--NLSFEPNFCQDNPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEE 160
D +K P + F N Q +P+ SE + +KV + DF
Sbjct: 913 DDLKEIPAEQMDFRANL---------------QRQVKPKTVSE-EERKVHSPQQVDF--- 953
Query: 161 LSSLFKSHSSKRIRPR-------ACKNHKSKLESQNKVMQENSSSFSD-LSERRERSSVP 212
S L K +SK P A + +S L + K+ EN SS ++ L+ + SS P
Sbjct: 954 RSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKP 1013
Query: 213 I----------PI----------------PADT-------RDNEVNHALEQQEAKRREAE 239
+ P+ PA+T + +E + ++E K+
Sbjct: 1014 LSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKN 1073
Query: 240 QAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQ 299
+ TT S E G P F QKL+ V EG ++ L C V PP
Sbjct: 1074 DVNCKRGHAGTTDNEKRS-----ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPAT 1128
Query: 300 VRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+ W GK L+ + I + Q G+L S++I +A ED G Y C A N G S ++ ++
Sbjct: 1129 IIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVD 1188
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSP 419
+S++ + P S P +S +PP ++ AT+++ +P
Sbjct: 1189 DAPASEN-----------TKAPEMKSRRPKSS--LPP-------VLGTESDATVKKKPAP 1228
Query: 420 TNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ II P ++ G+ V +V G W + I++S
Sbjct: 1229 KTPPKAAMPPQIIQFP------EDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESE 1282
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNED 537
++ E L I E GC+T NK G+ + L V D
Sbjct: 1283 HMKV--------ENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD 1332
Score = 76.3 bits (186), Expect = 2e-13
Identities = 105/449 (23%), Positives = 168/449 (37%), Gaps = 58/449 (12%)
Query: 739 PSSSPVFTLSSTPQTIQRTVSKESLLVSHP------SVQTKSPGGLSIQNEPLPPGPTEP 792
P+ F + Q +TVS+E V P SV K + E +PP +P
Sbjct: 919 PAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPP--PKP 976
Query: 793 TPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSA 852
P F + + S + ++ LS+ PS P P NA + A
Sbjct: 977 ATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNA----KPA 1032
Query: 853 PSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQQEYKISSFEQRL 912
++ G AK ++ +P+ + E + ++ KK +DV
Sbjct: 1033 ETLKPMGNAKP-AETLKPMGNAKPDENLKSASKEELKKDVKNDVN--------------- 1076
Query: 913 MNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIP 972
+R +D+E + + T AP F ++L+ V EG + C++ P
Sbjct: 1077 -------CKRGHAGTTDNEKRSESQGT----APAFKQKLQDVHVAEGKKLLLQCQVSSDP 1125
Query: 973 VPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSG 1032
+ W +GK + K + + +EG CS+ IE +D G Y +A N G+ CS
Sbjct: 1126 PATIIWTLNGKTL-KTTKFIILSQEGS-LCSVSIEKALPEDRGLYKCVAKNDAGQAECSC 1183
Query: 1033 HLMVQSLPIRSRLTSAGQ--SHRGRSRV-----QERD----KEPL----QERFFRPHFLQ 1077
+ V P S T A + S R +S + E D K+P + P +Q
Sbjct: 1184 QVTVDDAP-ASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ 1242
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
P D G L KV+G P TW + + + ++ H + L I
Sbjct: 1243 FPEDQKVRAGESVELFGKVTGTQPITCTW-MKFRKQIQESEHMKVENSENGSKLTILAAR 1301
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
Q G Y + NK G + L+VV K
Sbjct: 1302 QEHCGCYTLLVENKLGSRQAQVNLTVVDK 1330
Score = 65.9 bits (159), Expect = 3e-10
Identities = 85/382 (22%), Positives = 134/382 (35%), Gaps = 66/382 (17%)
Query: 940 GKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGD 999
G+C P F +L V EG F+CKI G P P+V W K + + G
Sbjct: 157 GEC-PPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGM 215
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
+H DD G YT + N G+ S S L +Q G RS V+
Sbjct: 216 QVLEIH--GVNQDDVGVYTCLVVNGSGKASMSAELSIQ-----------GLDSANRSFVR 262
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDC---KVSGLPPPELTWLLNGQPVLPD 1116
E R + + + + E +C + G PP W N QP P
Sbjct: 263 ETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPP----WAANSQPQPPR 318
Query: 1117 ASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN-KTGQNSFSLELSVVAKEVKKAPV-- 1173
S K+ + + P+ Q+ + + A + + L + + E +K P
Sbjct: 319 ES-KLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPP 377
Query: 1174 ----------------ILEKLQNCGVP----------------------EGHPVRLECRV 1195
++ K N +P E V+ C V
Sbjct: 378 RPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEV 437
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDT-TGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G+P P W + + I +++D + Y CLL A+ D+G Y+ +A N G
Sbjct: 438 SGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLL--KARTRDSGTYSCTASNAQGQ 495
Query: 1255 VSCTARLDIYAQWHHQIPPPMS 1276
+SC+ L + ++ P S
Sbjct: 496 LSCSWTLQVERLAVMEVAPSFS 517
Score = 64.3 bits (155), Expect = 7e-10
Identities = 32/108 (29%), Positives = 57/108 (52%), Gaps = 7/108 (6%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P F+K +++L EG F+C+++G P P+V W+++ I +S F+I +
Sbjct: 1809 PYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQI-------DYDE 1861
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+ C+L+I++V +D +TC A N G + A+L V E+ G
Sbjct: 1862 DGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEG 1909
Score = 63.5 bits (153), Expect = 1e-09
Identities = 35/114 (30%), Positives = 60/114 (52%), Gaps = 3/114 (2%)
Query: 262 EEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI--VQ 319
EE P F++ +R EV EG+ + DC + G P P+V W+ + + + S I +
Sbjct: 1802 EEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDE 1861
Query: 320 AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
GN SL I++ +D +Y+C A N G + +AE+ +E + + EG+ +E
Sbjct: 1862 DGNC-SLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE 1914
Score = 62.8 bits (151), Expect = 2e-09
Identities = 71/278 (25%), Positives = 111/278 (39%), Gaps = 49/278 (17%)
Query: 1053 RGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
RG + + +K + + P F Q D+ EG+ L C+VS PP + W LNG+
Sbjct: 1079 RGHAGTTDNEKRS-ESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGK- 1136
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---VAKEVK 1169
L +L +E + S+ I+ D G YKC+A N GQ S +++V A E
Sbjct: 1137 TLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENT 1196
Query: 1170 KAPVILEKLQNCGVPEGHPVRLECRV-----------IGMPPPVFYWKKD---------- 1208
KAP + + +P + V MPP + + +D
Sbjct: 1197 KAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVE 1256
Query: 1209 -------NETIPCT----RERI--SMH---QDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
+ I CT R++I S H +++ + L I A++ G YTL +N+
Sbjct: 1257 LFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKL 1316
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPSGS--RYGSLT 1288
G L + + P P + P S R SLT
Sbjct: 1317 GSRQAQVNLTVVDK-----PDPPAGTPCASDIRSSSLT 1349
Score = 60.8 bits (146), Expect = 8e-09
Identities = 74/295 (25%), Positives = 115/295 (38%), Gaps = 24/295 (8%)
Query: 396 PAVPQ-AQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
PA P+ A QP + + N ++G+ A P F Q+ E Q V F
Sbjct: 374 PAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKF 433
Query: 455 ECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFT 514
C V G P P+V W+ EGT + Q+ + E L + + DSG ++
Sbjct: 434 RCEVSGIPKPEVAWFLEGTPVR-------RQEGSIEVYEDAGSHYLCLLKARTRDSGTYS 486
Query: 515 CTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPP 574
CTASN G +S L V + S S + A IE Q SV P
Sbjct: 487 CTASNAQGQLSCSWTLQVERLAVMEVAPSFSSV--LKDCAVIEGQDFVLQC---SVRGTP 541
Query: 575 KPKLEGVLVNHNEP----RSSSRIG---LRVHFNLPEDDKGSEASSEAGVVTTRQTRPDS 627
P++ +L + +P RS+ G L + LPED +E + + +
Sbjct: 542 VPRITWLL--NGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVT 599
Query: 628 FQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPP 682
E+ + + ++ P +P K P+ + D + +QV + NPPP
Sbjct: 600 VHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMD--GSQVTMTVQVSGNPPP 652
Score = 58.9 bits (141), Expect = 3e-08
Identities = 50/167 (29%), Positives = 70/167 (41%), Gaps = 13/167 (7%)
Query: 404 LVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS 463
LVA ++ P+ +D P+ AP F +NL EG FE RV+G P
Sbjct: 6 LVASSHISKTSLSVDPSR----VDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 464 PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
P+V W+R G I F +L R +LVI V ED G +TC A+N G
Sbjct: 62 PQVTWHRNGQPITSGGRF-LLDCGIRG------TFSLVIHAVHEEDRGKYTCEATNGSGA 114
Query: 524 VSSIAQLHVRGN--EDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPP 568
+L V G+ + L + + A+E +PS PP
Sbjct: 115 RQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPP 161
Score = 56.6 bits (135), Expect = 2e-07
Identities = 30/96 (31%), Positives = 45/96 (46%)
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSL 1131
+P+F + D+ EG R DCK+ G P PE+ W + Q + ++ E G SL
Sbjct: 1808 KPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSL 1867
Query: 1132 LIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE 1167
+I + D Y C A N G+ + + EL V E
Sbjct: 1868 IISDVCGDDDAKYTCKAVNSLGEATCTAELIVETME 1903
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 2/146 (1%)
Query: 1142 GTYKCIATNKTGQNSFSLELSVV-AKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
G K +A++ + S S++ S V + + +AP + +N + EG + E RV G P
Sbjct: 2 GDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPE 61
Query: 1201 PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
P W ++ + I + R + G L+I + D G YT A N +G T
Sbjct: 62 PQVTWHRNGQPIT-SGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 1261 LDIYAQWHHQIPPPMSVRPSGSRYGS 1286
L + + Q+ P+ + G R+ +
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSA 146
Score = 50.8 bits (120), Expect = 8e-06
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 2/102 (1%)
Query: 1161 LSVVAKEVKKA-PVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
L VA+E P + +++ V EG R +C++ G P P W KD+++I +R
Sbjct: 1797 LEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESR-HF 1855
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ D G L+I D YT A N G +CTA L
Sbjct: 1856 QIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAEL 1897
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 1/99 (1%)
Query: 266 GQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLH 324
G P F K RS G V + C + G P P V W +GK L +++ ++Q ++
Sbjct: 718 GTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVF 777
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS 363
+L + + G+Y N G S + ++ S+
Sbjct: 778 TLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSA 816
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 113 bits (282), Expect = 1e-24
Identities = 93/348 (26%), Positives = 146/348 (41%), Gaps = 34/348 (9%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP+F L++ V +G PV+F C + G P+P V WFKDGK + + ++H + + G
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK-LLEEDDHYMINEDQQGGHQ 5183
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ----SLPIRSRLTSAGQSHRGRSRVQ 1059
L I + D G Y +A N G S L V + T + + +
Sbjct: 5184 LIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLS 5243
Query: 1060 ERDKEPLQERFFRPHFLQAPGDM----VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
R++E + Q ++ VA RL + KV G P P L W +GQP+
Sbjct: 5244 SREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTA 5303
Query: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---------VAK 1166
A +M ++ +H+L I +T+ D+G Y +N G S L V A
Sbjct: 5304 SAHIRMTDKKI-LHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPAS 5362
Query: 1167 EVKK---APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQ 1223
+V + P +LE+ V +G + +V G P P +W ++ R + +
Sbjct: 5363 DVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREE----AERGVLWIGP 5418
Query: 1224 DTTGYA--------CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
DT GY L++ + G YT A N AG C+A L +
Sbjct: 5419 DTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 5466
Score = 101 bits (251), Expect = 5e-21
Identities = 96/339 (28%), Positives = 131/339 (38%), Gaps = 58/339 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F R K F V+ G T +C+IVG P P+V W KD + ++ ++ ++GD
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAA-GARFRLAQDGD-LYR 66
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I D G Y A N G + L V + A Q+
Sbjct: 67 LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDA-----EAACAEQA------------ 109
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
PHFL P + EG C+V G P P ++W +G+ + ++ V
Sbjct: 110 ---------PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRV 160
Query: 1124 RETGVHSLL-IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP-------VIL 1175
E G S L I RD GTY+ A N G S + L V + A +L
Sbjct: 161 EELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALL 220
Query: 1176 EKLQN---------------------CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPC 1214
LQ C V EG RL C V G P P WKKD + +
Sbjct: 221 AHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTE 280
Query: 1215 TRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
R + +++D L I K+SD G YT +A N G
Sbjct: 281 GRRHV-VYEDAQENFVLKILFCKQSDRGLYTCTASNLVG 318
Score = 98.6 bits (244), Expect = 4e-20
Identities = 86/305 (28%), Positives = 134/305 (43%), Gaps = 48/305 (15%)
Query: 236 REAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
R E S+ P SL + P F +L+++EV +G V DC+V G
Sbjct: 5096 RRVEMCISKETPAPVVPPEPLPSLLTSDAA---PVFLTELQNQEVQDGYPVSFDCVVTGQ 5152
Query: 296 PPPQVRWYCEGKELENSPD--IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
P P VRW+ +GK LE I+ Q G H L I D G Y C A N G ST
Sbjct: 5153 PMPSVRWFKDGKLLEEDDHYMINEDQQGG-HQLIITAVVPADMGVYRCLAENSMGVSSTK 5211
Query: 354 AEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATI 413
AE+ ++ ++S+D + T+A A + + AQ +++
Sbjct: 5212 AELRVD-LTSTDYD----------------------TAA---DATESSSYFSAQGYLSSR 5245
Query: 414 QQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEG-QLVVFECRVKGAPSPKVEWYREG 472
+Q + + +G P + L++L + G +L F+ +VKG P+P++ W+++G
Sbjct: 5246 EQEGTESTTDEG-------QLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDG 5298
Query: 473 TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ S R+ KK + TL I V EDSG + SN G S A+L V
Sbjct: 5299 QPLTASAHIRMTDKK--------ILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLV 5350
Query: 533 RGNED 537
RG ++
Sbjct: 5351 RGPDE 5355
Score = 88.2 bits (217), Expect = 5e-17
Identities = 90/354 (25%), Positives = 140/354 (39%), Gaps = 75/354 (21%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGN-LHSLT 327
P F+ E G ++L+C+V + RW +G EL + HI Q G+ SL
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLL 4957
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-------------E 374
I D G Y+C SN +G + SA + + G S S++E E
Sbjct: 4958 ITGLDRADAGCYTCQVSNKFGQVTHSACVVVSG-SESEAESSSGGELDDAFRRAARRLHR 5016
Query: 375 MNRIQKPNEVSSPPT-TSAVIPPAVPQA----------QHLVAQPRVATIQQCQSPTNYL 423
+ R + P EVS SA PA P+ +H + A + Q+ T +
Sbjct: 5017 LFRTKSPAEVSDEELFLSADEGPAEPEEPADWQTYREDEHFICIRFEALTEARQAVTRFQ 5076
Query: 424 Q-------GLDGK-------------------PII------------AAPVFTKMLQNLS 445
+ G++ K P++ AAPVF LQN
Sbjct: 5077 EMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQE 5136
Query: 446 ASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEV 505
+G V F+C V G P P V W+++G L+E+ + I + + L+I V
Sbjct: 5137 VQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGH-------QLIITAV 5189
Query: 506 FAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQ 559
D G + C A N G S+ A+L V DL++ +A++T + + Q
Sbjct: 5190 VPADMGVYRCLAENSMGVSSTKAELRV----DLTSTDYDTAADATESSSYFSAQ 5239
Score = 87.8 bits (216), Expect = 6e-17
Identities = 78/256 (30%), Positives = 110/256 (42%), Gaps = 12/256 (4%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F R RV EGS TF C++ G P P V W KDG+++ + + E +
Sbjct: 109 APHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASA 168
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + D G Y + A NP G S + L+V S + G S +R +
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVVDS-DAADTASRPGTSTAALLAHLQRRR 227
Query: 1064 EPLQERFFRPHFLQAPG--DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
E ++ P + G EG+ RL C V+G P PE W +GQ V H
Sbjct: 228 EAMRAE-GAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRH-- 284
Query: 1122 LVRETGVHSLLIDPL--TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ 1179
+V E + ++ L Q D G Y C A+N GQ ++S L VV + A ++LQ
Sbjct: 285 VVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQ-TYSSVLVVVR---EPAVPFKKRLQ 340
Query: 1180 NCGVPEGHPVRLECRV 1195
+ V E C V
Sbjct: 341 DLEVREKESATFLCEV 356
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/191 (27%), Positives = 85/191 (44%), Gaps = 5/191 (2%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F + D A G +L C+V+G P P ++W +G+ V D H ++ G +L+
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+D LT D+G Y C A + G S ++ V+ P + K++ EG +
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKIL-----VQVPPRFVNKVRASPFVEGEDAQFT 6128
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C + G P P W KD + + ++ + +G L+I+ A K D G Y N
Sbjct: 6129 CTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRL 6188
Query: 1253 GIVSCTARLDI 1263
G +A L I
Sbjct: 6189 GSARASAELRI 6199
Score = 80.9 bits (198), Expect = 8e-15
Identities = 57/191 (29%), Positives = 86/191 (45%), Gaps = 3/191 (1%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P FL P V G+ L C++ G P P+++W + QPV A + L ++ ++ L
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFR-LAQDGDLYRLT 68
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE--VKKAPVILEKLQNCGVPEGHPVR 1190
I L D+G Y C A N G+ ++ L V A+ ++AP L + + V EG
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
CRV G P P W KD + ++ + L I+ A+ D G Y + A+N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Query: 1251 EAGIVSCTARL 1261
G S A L
Sbjct: 189 PLGAASAAAAL 199
Score = 79.0 bits (193), Expect = 3e-14
Identities = 66/276 (23%), Positives = 107/276 (38%), Gaps = 71/276 (25%)
Query: 266 GQPPRFTQKLRSREVPEGTRV-QLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
GQ P+ ++LR +V GTR+ + V G P P++ W+ +G+ L S I + LH
Sbjct: 5257 GQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILH 5316
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
+L I ED+G+Y+ + SN G +SA + + G +P E
Sbjct: 5317 TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPD-----------------EPEEK 5359
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
+ ++PP + L+ K +
Sbjct: 5360 PASDVHEQLVPPRM------------------------LERFTPKKV------------- 5382
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGT------LIEDSPDFRILQKKPRSMAEPEEIC 498
+G + F +V+G P P V W RE + D+P + + A +
Sbjct: 5383 --KKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTV--------ASSAQQH 5432
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+LV+ +V + G +TC ASN G A LHV G
Sbjct: 5433 SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468
Score = 79.0 bits (193), Expect = 3e-14
Identities = 54/220 (24%), Positives = 86/220 (39%), Gaps = 35/220 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F++ L G V C++ G P P + W+KDGK + H + + DG+C+L
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHI-LIEDPDGSCAL 6072
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
++S T D G Y AA+ G S G ++VQ
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ--------------------------- 6105
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P F+ EG + C + G P P++ W +G + + L
Sbjct: 6106 ------VPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSE 6159
Query: 1125 -ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
+G+ L+I ++ D G Y+C N+ G S EL +
Sbjct: 6160 PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 66.2 bits (160), Expect = 2e-10
Identities = 67/269 (24%), Positives = 106/269 (39%), Gaps = 49/269 (18%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLH 324
Q P F + S V EG+ C V G P P V W +G+ L + P + + + G
Sbjct: 108 QAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEAS 167
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
+L I A D G Y A N G S +A + ++ SD+ +
Sbjct: 168 ALRIRAARPRDGGTYEVRAENPLGAASAAAALVVD----SDA--------------ADTA 209
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
S P T++A + +A +Q+ + +G P A+P T +
Sbjct: 210 SRPGTSTAAL---------------LAHLQRRREAMR----AEGAP--ASPPSTG-TRTC 247
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
+ +EG+ C V G P P+ W ++G L+ + + + + +E L I
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYE-------DAQENFVLKILF 300
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
D G +TCTASN G S + VR
Sbjct: 301 CKQSDRGLYTCTASNLVGQTYSSVLVVVR 329
Score = 65.9 bits (159), Expect = 3e-10
Identities = 81/317 (25%), Positives = 121/317 (38%), Gaps = 57/317 (17%)
Query: 946 IFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLH 1005
+F + L +TEG +T C+ +P V W KDGK + + + C++ EG L
Sbjct: 3097 VFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDGKTL-RGSARCQLSHEGH-RAQLL 3153
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLM-VQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T D G Y A +CS ++ V + P+R
Sbjct: 3154 ITGATLQDSGRYKCEAGG-----ACSSSIVRVHARPVR---------------------- 3186
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
F +A D+ EG L C +S + P + W G VL L +
Sbjct: 3187 ----------FQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCY-GNNVLRPGDKYSLRQ 3234
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
E + L++ L +D+G Y C G + S L+V A + + KL+N
Sbjct: 3235 EGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQ----FIGKLRNKEAT 3286
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAKKSDAGW 1243
EG L C + P W+K +ET+ +R + QD G C L I+ DA
Sbjct: 3287 EGATATLRCELSKAAP--VEWRKGSETLR-DGDRYCLRQD--GAMCELQIRGLAMVDAAE 3341
Query: 1244 YTLSAKNEAGIVSCTAR 1260
Y+ E S T R
Sbjct: 3342 YSCVCGEERTSASLTIR 3358
Score = 64.7 bits (156), Expect = 6e-10
Identities = 76/303 (25%), Positives = 122/303 (40%), Gaps = 41/303 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P + LR + E R L+C V QVRW+ +EL+ P +V G L
Sbjct: 2289 PVTLVRPLRDKIAMEKHRGVLEC-QVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLI 2347
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I++ ED Y+C A ++ TSA+ ++E S + G + M P
Sbjct: 2348 ISDVHAEDEDTYTCDAGDV----KTSAQFFVEEQSITIVRGLQDVTVME--PAPAWFECE 2401
Query: 388 PTTSAVIPP------AVPQAQHLVAQPRVATIQQ------CQSPTNYLQGLDGKPIIAA- 434
+ +V PP V QA V + T+ + C + T + GK +A
Sbjct: 2402 TSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSAR 2461
Query: 435 -------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
V T+ L+ + E Q VV C + AP V+WY++ T + S F+
Sbjct: 2462 LVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPK-AVQWYKDDTPLSPSEKFK----- 2515
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSA 547
M+ ++ L I + D+G + C A G+ S ++ V E ++ G L A
Sbjct: 2516 ---MSLEGQMAELRILRLMPADAGVYRCQA----GSAHSSTEVTVEARE-VTVTGPLQDA 2567
Query: 548 NST 550
+T
Sbjct: 2568 EAT 2570
Score = 63.2 bits (152), Expect = 2e-09
Identities = 43/166 (25%), Positives = 67/166 (40%), Gaps = 5/166 (3%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQ--AGNLHS 325
PPRF K+R+ EG Q C + G P PQ+RWY +G L + L
Sbjct: 6107 PPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLV 6166
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVS 385
L I A +ED G Y C N G+ SAE+ I+ E ++ + ++ + +
Sbjct: 6167 LVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQLVAAVEVTEQET 6226
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI 431
P + +I + +V PR +SP+ P+
Sbjct: 6227 KVPKKTVIIEETITT---VVKSPRGQRRSPSKSPSRSPSRCSASPL 6269
Score = 62.4 bits (150), Expect = 3e-09
Identities = 66/308 (21%), Positives = 106/308 (34%), Gaps = 83/308 (26%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
PRF + ++ V G L C +VG P PQV W + + + + Q G+L+ LTI
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
+ D+G+Y C A N G + + ++ ++
Sbjct: 70 LDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA------------------------- 104
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
QA H + +P +++
Sbjct: 105 --------CAEQAPHFLLRPTSIRVRE--------------------------------- 123
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLI--EDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
G F CRV G+P P V W ++G + D P R+ E E L I
Sbjct: 124 GSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRV--------EELGEASALRIRAAR 175
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSE 566
D G + A N G S+ A L V + D ++ S ++ LA ++ + +E
Sbjct: 176 PRDGGTYEVRAENPLGAASAAAALVV--DSDAADTASRPGTSTAALLAHLQRRREAMRAE 233
Query: 567 -----PPS 569
PPS
Sbjct: 234 GAPASPPS 241
Score = 61.2 bits (147), Expect = 6e-09
Identities = 76/312 (24%), Positives = 115/312 (36%), Gaps = 54/312 (17%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F + L++ TEG T C++ V W K + + + H +R++G C L I
Sbjct: 3716 FIEGLRNEEATEGDTATLWCELS--KAAPVEWRKGHETLRDGDRH-SLRQDGS-RCELQI 3771
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
D G Y+ + G+ S L V++LP R
Sbjct: 3772 RGLAVVDAGEYSCVC----GQERTSATLTVRALPAR------------------------ 3803
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
F++ + A EG L C++S P E W G L L ++
Sbjct: 3804 --------FIEDVKNQEAREGATAVLQCELSKAAPVE--W-RKGSETLRGGDRYSLRQDG 3852
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
L I L+ D G Y C+ GQ S L+V A + PV E LQ+ EG
Sbjct: 3853 TRCELQIHGLSVADTGEYSCVC----GQERTSATLTVRAPQ----PVFREPLQSLQAEEG 3904
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
L+C + P W K + R Q T A L++Q ++ D G YT
Sbjct: 3905 STATLQCE-LSEPTATVVWSKGGLQLQANGRREPRLQGCT--AELVLQDLQREDTGEYTC 3961
Query: 1247 SAKNEAGIVSCT 1258
+ ++A + T
Sbjct: 3962 TCGSQATSATLT 3973
Score = 60.1 bits (144), Expect = 1e-08
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 7/104 (6%)
Query: 430 PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
P+ P F + L + +A G+ V CRV G P P + WY++G ++ P +++
Sbjct: 6009 PVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIE---- 6064
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+P+ C L++ + DSG + C A++ G S++ ++ V+
Sbjct: 6065 ---DPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ 6105
Score = 59.3 bits (142), Expect = 2e-08
Identities = 77/315 (24%), Positives = 121/315 (38%), Gaps = 57/315 (18%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F + L++ TEG+ C++ + V W+K + + + H +R++G C L I
Sbjct: 3628 FTEGLRNEEATEGATAVLRCELS--KMAPVEWWKGHETLRDGDRH-SLRQDG-ARCELQI 3683
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
++D G Y M G+ S L V+++P +
Sbjct: 3684 RGLVAEDAGEYLCMC----GKERTSAMLTVRAMPSK------------------------ 3715
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
F++ + A EG L C++S P E W G L D L ++
Sbjct: 3716 --------FIEGLRNEEATEGDTATLWCELSKAAPVE--WR-KGHETLRDGDRHSLRQDG 3764
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
L I L DAG Y C+ GQ S L+V A + +E ++N EG
Sbjct: 3765 SRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPAR----FIEDVKNQEAREG 3816
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAKKSDAGWYT 1245
L+C + P W+K +ET+ +R S+ QD G C L I +D G Y+
Sbjct: 3817 ATAVLQCELSKAAP--VEWRKGSETLR-GGDRYSLRQD--GTRCELQIHGLSVADTGEYS 3871
Query: 1246 LSAKNEAGIVSCTAR 1260
E + T R
Sbjct: 3872 CVCGQERTSATLTVR 3886
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/180 (25%), Positives = 76/180 (42%), Gaps = 30/180 (16%)
Query: 221 DNEVNHALEQQEAKRREAEQAA---SEAAG-----------GDTTPGSSPSSLYYEEPLG 266
D ++ H LE R ++ Q A S A G G P P+S +E+ +
Sbjct: 5311 DKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV- 5369
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL------ENSPDIHIVQA 320
PPR ++ ++V +G+ + V G P P V W E E ++P + +
Sbjct: 5370 -PPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
HSL + + + G Y+C ASN G SA +++ G+ P EE ++++
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL--------PKVEEQEKVKE 5480
Score = 56.2 bits (134), Expect = 2e-07
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 428 GKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
GK ++ P F ++ EG+ F C ++GAP P++ WY++G L+ F+ L
Sbjct: 6100 GKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTL-S 6158
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+PRS + LVI ED G + C N+ G+ + A+L ++
Sbjct: 6159 EPRS-----GLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQ 6200
Score = 55.5 bits (132), Expect = 3e-07
Identities = 72/323 (22%), Positives = 120/323 (37%), Gaps = 53/323 (16%)
Query: 939 TGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG 998
T + + F + +K+ EG+ C++ V W K G + + + +R++G
Sbjct: 3796 TVRALPARFIEDVKNQEAREGATAVLQCELS--KAAPVEWRK-GSETLRGGDRYSLRQDG 3852
Query: 999 DGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRV 1058
C L I + D G Y+ +
Sbjct: 3853 T-RCELQIHGLSVADTGEYSCVCG------------------------------------ 3875
Query: 1059 QERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAS 1118
QER L R +P F + + A EG L C++S P + W G + +
Sbjct: 3876 QERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGR 3934
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
+ ++ +L D L + D G Y C G + S L+V A V+ L +L
Sbjct: 3935 REPRLQGCTAELVLQD-LQREDTGEYTCTC----GSQATSATLTVTAAPVR----FLREL 3985
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ V EG L C + V + K + PC + + M QD A LL++ ++
Sbjct: 3986 QHQEVDEGGTAHLCCELSRAGASVEWRKGSLQLFPCAKYQ--MVQDGAA-AELLVRGVEQ 4042
Query: 1239 SDAGWYTLSAKNEAGIVSCTARL 1261
DAG YT + + S + R+
Sbjct: 4043 EDAGDYTCDTGHTQSMASLSVRV 4065
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Query: 264 PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP-DIHIVQAGN 322
P+ +PP F ++L G V+L C V G P P + WY +GK ++ P I I
Sbjct: 6009 PVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG 6068
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+L + D+G+Y CFA++ G ST +I ++
Sbjct: 6069 SCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ 6105
Score = 55.1 bits (131), Expect = 4e-07
Identities = 47/194 (24%), Positives = 77/194 (39%), Gaps = 26/194 (13%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F +++ EG FTC I G P P++ W+KDG ++ N+ + G
Sbjct: 6106 VPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLL 6165
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPI-------RSRLTSAGQSHRGR 1055
L I + + +D G Y N G S L +QS + R +L +A +
Sbjct: 6166 VLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQLVAAVEVTEQE 6225
Query: 1056 SRVQERD-----------KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPEL 1104
++V ++ K P +R ++P + C GL P+L
Sbjct: 6226 TKVPKKTVIIEETITTVVKSPRGQR-------RSPSKSPSRSPSRCSASPLRPGLLAPDL 6278
Query: 1105 TWLLN-GQPVLPDA 1117
+L GQP P+A
Sbjct: 6279 LYLPGAGQPRRPEA 6292
Score = 54.7 bits (130), Expect = 6e-07
Identities = 82/323 (25%), Positives = 117/323 (36%), Gaps = 57/323 (17%)
Query: 939 TGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG 998
T K + F + L++ EG+ C++ V V W K G + + + +R+EG
Sbjct: 3444 TVKALPAKFTEGLRNEEAVEGATAMLWCELS--KVAPVEWRK-GPENLRDGDRYILRQEG 3500
Query: 999 DGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRV 1058
C L I D G Y + G+ S L +++LP R
Sbjct: 3501 T-RCELQICGLAMADAGEYLCVC----GQERTSATLTIRALPAR---------------- 3539
Query: 1059 QERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAS 1118
F++ + A EG L C+++ P E W G L D
Sbjct: 3540 ----------------FIEDVKNQEAREGATAVLQCELNSAAPVE--W-RKGSETLRDGD 3580
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
L ++ L I L D G Y C+ GQ S L+V A +K E L
Sbjct: 3581 RYSLRQDGTKCELQIRGLAMADTGEYSCVC----GQERTSAMLTVRALPIK----FTEGL 3632
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAK 1237
+N EG L C + M P W K +ET+ +R S+ QD G C L I+
Sbjct: 3633 RNEEATEGATAVLRCELSKMAP--VEWWKGHETLR-DGDRHSLRQD--GARCELQIRGLV 3687
Query: 1238 KSDAGWYTLSAKNEAGIVSCTAR 1260
DAG Y E T R
Sbjct: 3688 AEDAGEYLCMCGKERTSAMLTVR 3710
Score = 53.5 bits (127), Expect = 1e-06
Identities = 73/304 (24%), Positives = 118/304 (38%), Gaps = 38/304 (12%)
Query: 249 DTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV-RWYCEGK 307
DT S +SL P P+F +L+S E G +L C + V +W EG
Sbjct: 4051 DTGHTQSMASLSVRVPR---PKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGV 4107
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI--------YIE 359
EL P + G L I + +DTG Y+C + G T+A + +
Sbjct: 4108 ELHAGPKYEMRSQGATRELLIHQLEAKDTGEYAC----VTGGQKTAASLRVTEPEVTIVR 4163
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEV-------SSPPTTSAVIPPAVPQAQHLVAQPRVAT 412
G+ ++ D + E + + P ++ V AV + + + T
Sbjct: 4164 GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVT 4223
Query: 413 IQQCQSPTNYL--QGLDGKPIIAAPVFT--KMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ + + +L + + AP T + LQ++ SEGQ F+CR+ A + W
Sbjct: 4224 PEDAGTVSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARW 4283
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIA 528
G ++ + I E + L + +V ED+G T S GT SS A
Sbjct: 4284 ALGGVPLQANEMNDI-------TVEQGTLHLLTLHKVTLEDAG----TVSFHVGTCSSEA 4332
Query: 529 QLHV 532
QL V
Sbjct: 4333 QLKV 4336
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/323 (23%), Positives = 120/323 (37%), Gaps = 54/323 (16%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
A F + L + +V E FTCK P V W K ++ +H + +EG T
Sbjct: 2915 ANCFTEELTNLQVEEKGTAVFTCKTEH-PAATVTWRKGLLELRASGKH-QPSQEGL-TLR 2971
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + D YT Q R L+VQ GR
Sbjct: 2972 LTISALEKADSDTYTCDIGQAQSR----AQLLVQ----------------GR-------- 3003
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
R H ++ D+ EG C++S + W L+ P+ + +++
Sbjct: 3004 --------RVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDA 3055
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGV 1183
+ G H L + L +D+GT A ++ S + +K V +L + +
Sbjct: 3056 QPGGYHVLTLRQLALKDSGTIYFEAGDQ--------RASAALRVTEKPSVFSRELTDATI 3107
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
EG + L C PV W KD +T+ + H+ A LLI A D+G
Sbjct: 3108 TEGEDLTLVCETSTCDIPV-CWTKDGKTLRGSARCQLSHEGHR--AQLLITGATLQDSGR 3164
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQ 1266
Y K EAG ++ + ++A+
Sbjct: 3165 Y----KCEAGGACSSSIVRVHAR 3183
Score = 52.4 bits (124), Expect = 3e-06
Identities = 78/347 (22%), Positives = 124/347 (35%), Gaps = 56/347 (16%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+F G + C + + W KDG +++ H + + GDGTCSL
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHH-HIDQLGDGTCSL 4956
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I D G YT +N G+++ S ++V + +S G+ R R
Sbjct: 4957 LITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARR--- 5013
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
R FR ++P + + EL + P P+
Sbjct: 5014 --LHRLFR---TKSPAE-----------------VSDEELFLSADEGPAEPEEPADWQTY 5051
Query: 1125 ETGVHSLLI--DPLTQ-RDAGT--YKCIATNKTG-------QNSFSLELSVVAKEVKKAP 1172
H + I + LT+ R A T + AT G Q +E+ ++KE
Sbjct: 5052 REDEHFICIRFEALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEM-CISKETPAPV 5110
Query: 1173 VILEKLQNCGVPEGHPVRL----------------ECRVIGMPPPVFYWKKDNETIPCTR 1216
V E L + + PV L +C V G P P W KD + +
Sbjct: 5111 VPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE-ED 5169
Query: 1217 ERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+ +++D G L+I +D G Y A+N G+ S A L +
Sbjct: 5170 DHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRV 5216
Score = 52.0 bits (123), Expect = 4e-06
Identities = 33/110 (30%), Positives = 50/110 (45%), Gaps = 7/110 (6%)
Query: 1164 VAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQ 1223
+A V + P E+L +C G V+L CRV G P PV W KD + + I + +
Sbjct: 6006 LALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHI-LIE 6064
Query: 1224 DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
D G L++ D+G Y A + AG S ++ + Q+PP
Sbjct: 6065 DPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV------QVPP 6108
Score = 51.2 bits (121), Expect = 6e-06
Identities = 72/283 (25%), Positives = 109/283 (38%), Gaps = 56/283 (19%)
Query: 972 PVPK-VYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISC 1030
P PK V W+KD +S +E KM EG L I D G Y A
Sbjct: 2494 PAPKAVQWYKDDTPLSP-SEKFKMSLEGQ-MAELRILRLMPADAGVYRCQAG-------- 2543
Query: 1031 SGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLC 1090
S H + +T G PLQ D A E
Sbjct: 2544 SAHSSTEVTVEAREVTVTG---------------PLQ-------------DAEATEEGWA 2575
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
C++S E+ W LNG P+ D+ H+ + + H+L++ + + DAG +
Sbjct: 2576 SFSCELSH-EDEEVEWSLNGMPLYNDSFHE-ISHKGRRHTLVLKSIQRADAGIVR----- 2628
Query: 1151 KTGQNSFSLELSVVAK-EVKKAPVI-LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKD 1208
+ SL++S A+ EV+ PV+ L+ L + E + L+C V P W+KD
Sbjct: 2629 -----ASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEV-SDPEAHVVWRKD 2682
Query: 1209 NETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ + + +H T G L++ DAG YT +E
Sbjct: 2683 GVQLGPSDKYDFLH--TAGTRGLVVHDVSPEDAGLYTCHVGSE 2723
Score = 50.4 bits (119), Expect = 1e-05
Identities = 74/303 (24%), Positives = 110/303 (36%), Gaps = 66/303 (21%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+F + L+ + EGS T C++ P V W K G Q+ + N + R +G T L
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQL-QANGRREPRLQGC-TAEL 3946
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
++ +D G YT G + S L V + P+R
Sbjct: 3947 VLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVR---------------------- 3980
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
FL+ EG L C++S + W + P A ++M V+
Sbjct: 3981 ----------FLRELQHQEVDEGGTAHLCCELSRAGA-SVEWRKGSLQLFPCAKYQM-VQ 4028
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
+ LL+ + Q DAG Y C TG LSV P +LQ+
Sbjct: 4029 DGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPR----PKFKTRLQSLEQE 4080
Query: 1185 EGHPVRLECRVIGMPP-PVFYWKKDNETI-----------PCTRERISMHQ----DTTGY 1228
G RL C++ V W K+ + TRE + +HQ DT Y
Sbjct: 4081 TGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRE-LLIHQLEAKDTGEY 4139
Query: 1229 ACL 1231
AC+
Sbjct: 4140 ACV 4142
Score = 49.7 bits (117), Expect = 2e-05
Identities = 73/307 (23%), Positives = 120/307 (39%), Gaps = 51/307 (16%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSL 326
P +F + LR+ E EG L C + P + R +G E D H + Q G+ L
Sbjct: 3713 PSKFIEGLRNEEATEGDTATLWCELSKAAPVEWR---KGHETLRDGDRHSLRQDGSRCEL 3769
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I D G YSC + G + TSA + + + + E N+E + V
Sbjct: 3770 QIRGLAVVDAGEYSC----VCGQERTSATLTVRALPARFIEDVKNQEAR---EGATAVLQ 3822
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQ---QCQSPTNYLQGLD--------GKPIIAA- 434
+ A ++ L R + Q +C+ + L D G+ +A
Sbjct: 3823 CELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSAT 3882
Query: 435 -------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
PVF + LQ+L A EG +C + P+ V W + G LQ +
Sbjct: 3883 LTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-----------LQLQ 3930
Query: 488 PRSMAEPE-EICT--LVIAEVFAEDSGCFTCTASNKYG------TVSSIAQLHVRGNEDL 538
EP + CT LV+ ++ ED+G +TCT ++ T + + L ++++
Sbjct: 3931 ANGRREPRLQGCTAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEV 3990
Query: 539 SNNGSLH 545
G+ H
Sbjct: 3991 DEGGTAH 3997
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/381 (23%), Positives = 140/381 (36%), Gaps = 81/381 (21%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F++ L+ E +V L+C + P VRW +G EL + I G SLT
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLEC-ELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I D G Y C A + +SA + ++G + + E+ IQ
Sbjct: 2224 IYRCEFADQGVYVCDAHDA----QSSASVKVQGRTYTLIYRRVLAEDAGEIQ-------- 2271
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSAS 447
V A +AQ V + V + + L++ A
Sbjct: 2272 ----FVAENAESRAQLRVKELPVTLV-------------------------RPLRDKIAM 2302
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
E V EC+V A S +V W++ ++ P + ++ L+I++V A
Sbjct: 2303 EKHRGVLECQVSRA-SAQVRWFKGSQELQPGPKYELVSDGLYR--------KLIISDVHA 2353
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEP 567
ED +TC A G V + AQ V S+ ++ +EP P+ E
Sbjct: 2354 EDEDTYTCDA----GDVKTSAQFFV-------EEQSITIVRGLQDVTVMEPAPAWFECET 2402
Query: 568 --PSVEQPPKPKL---------------EGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSE 610
PSV +PPK L EG + R+ S + VHF + + +
Sbjct: 2403 SIPSV-RPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSAR 2461
Query: 611 -ASSEAGVVTTRQTRPDSFQE 630
S+ VV TR P + +E
Sbjct: 2462 LVVSDIPVVLTRPLEPKTGRE 2482
Score = 48.9 bits (115), Expect = 3e-05
Identities = 85/400 (21%), Positives = 143/400 (35%), Gaps = 76/400 (19%)
Query: 158 IEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPA 217
I E +F S +A + L + Q + + D + S V + +
Sbjct: 1067 ITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYKDGKKLSSSSKVGMEVKG 1126
Query: 218 DTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRS 277
TR L +A + +A + + EA G + L+ EP G +
Sbjct: 1127 CTR------RLVLPQAGKADAGEYSCEAGGQRVS-----FHLHITEPKGVFAKEQSVHNE 1175
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
+ GT L C V P +V WY +GK+L +S + + G L + + + D G
Sbjct: 1176 VQAEAGTTAMLSCEVAQ-PQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAG 1234
Query: 338 RYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPA 397
YSC A G S +++I ++ + KE++ NEV + SA +
Sbjct: 1235 EYSCEA----GGQRVSFQLHI-----TEPKAVFAKEQLVH----NEVRTEAGASATLSCE 1281
Query: 398 VPQAQHLVAQ--------------------PRVATIQQC--------------QSPTNYL 423
V QAQ V R +QQ Q + +L
Sbjct: 1282 VAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHL 1341
Query: 424 QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
+ K + A + + A G + C V A + +V WY++G + S R+
Sbjct: 1342 DVSEPKAVFAKEQLAH--RKVQAEAGAIATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRM 1398
Query: 484 LQKKPRSMAEPEEI-CT--LVIAEVFAEDSGCFTCTASNK 520
E + CT LV+ + D+G ++C A +
Sbjct: 1399 -----------EAVGCTRRLVVQQACQADTGEYSCEAGGQ 1427
Score = 48.9 bits (115), Expect = 3e-05
Identities = 78/315 (24%), Positives = 115/315 (36%), Gaps = 57/315 (18%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F +L++ TEG+ T C++ V W K + + + +C +R++G C L I
Sbjct: 3276 FIGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLRDGDRYC-LRQDG-AMCELQI 3331
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
D Y+ + G S L ++ +P GR R QE
Sbjct: 3332 RGLAMVDAAEYSCVC----GEERTSASLTIRPMPAH---------FIGRLRHQE------ 3372
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
+ EG L C++S P E W G+ L D L ++
Sbjct: 3373 -----------------SIEGATATLRCELSKAAPVE--WR-KGRESLRDGDRHSLRQDG 3412
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
V L I L DAG Y C+ G+ S L+V A K E L+N EG
Sbjct: 3413 AVCELQICGLAVADAGEYSCVC----GEERTSATLTVKALPAK----FTEGLRNEEAVEG 3464
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAKKSDAGWYT 1245
L C + + P W+K E + +R + Q+ G C L I +DAG Y
Sbjct: 3465 ATAMLWCELSKVAP--VEWRKGPENLR-DGDRYILRQE--GTRCELQICGLAMADAGEYL 3519
Query: 1246 LSAKNEAGIVSCTAR 1260
E + T R
Sbjct: 3520 CVCGQERTSATLTIR 3534
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/102 (31%), Positives = 52/102 (50%), Gaps = 8/102 (7%)
Query: 1094 CKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTG 1153
C+VS + W L G P+ + ++ VR+ +H+L + +T DAGT + G
Sbjct: 4180 CEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGT----VSFHLG 4235
Query: 1154 QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
++ S +L+V A EV ILE LQ+ + EG +CR+
Sbjct: 4236 NHASSAQLTVRAPEV----TILEPLQDVQLSEGQDASFQCRL 4273
Score = 48.5 bits (114), Expect = 4e-05
Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 5/122 (4%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLR--SREVPE--G 283
+E RR Q A +A G+ + + L + + +P K + SREV G
Sbjct: 1490 MEAVGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAG 1549
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
T L C V +V WY +GK+L +S + + G L + EA + D G YSC A
Sbjct: 1550 TSATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKA 1608
Query: 344 SN 345
+
Sbjct: 1609 GD 1610
Score = 48.1 bits (113), Expect = 5e-05
Identities = 55/257 (21%), Positives = 90/257 (35%), Gaps = 46/257 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
VT V F+C++ V W G + NE ++ +L ++ T +D G
Sbjct: 4170 VTADEDVEFSCEVSRAGATGVQWCLQGLPLQS-NEVTEVAVRDGRIHTLRLKGVTPEDAG 4228
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+ N H L +R+ + EPLQ
Sbjct: 4229 TVSFHLGN---------HASSAQLTVRAPEVTI--------------LEPLQ-------- 4257
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
D+ EG+ C++S E W L G P+ + + + V + +H L +
Sbjct: 4258 -----DVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHK 4312
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
+T DAGT + G S +L V AK ++ L+N EG EC++
Sbjct: 4313 VTLEDAGT----VSFHVGTCSSEAQLKVTAKN-----TVVRGLENVEALEGGEALFECQL 4363
Query: 1196 IGMPPPVFYWKKDNETI 1212
W D+E +
Sbjct: 4364 SQPEVAAHTWLLDDEPV 4380
Score = 47.8 bits (112), Expect = 7e-05
Identities = 67/268 (25%), Positives = 101/268 (37%), Gaps = 40/268 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +FT+ LR+ E EG L C + + P V W + L + + Q G L
Sbjct: 3449 PAKFTEGLRNEEAVEGATAMLWCELSKVAP--VEWRKGPENLRDGDRYILRQEGTRCELQ 3506
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I D G Y C + G + TSA + I + + E N+E + V
Sbjct: 3507 ICGLAMADAGEYLC----VCGQERTSATLTIRALPARFIEDVKNQEAR---EGATAVLQC 3559
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL----DGK-------------- 429
SA ++ L R + Q ++GL G+
Sbjct: 3560 ELNSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTSAML 3619
Query: 430 PIIAAPV-FTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTLIEDSPDFRILQKK 487
+ A P+ FT+ L+N A+EG V C + K AP VEW++ + D + Q
Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP---VEWWKGHETLRDGDRHSLRQDG 3676
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTC 515
R C L I + AED+G + C
Sbjct: 3677 AR--------CELQIRGLVAEDAGEYLC 3696
Score = 47.4 bits (111), Expect = 9e-05
Identities = 67/289 (23%), Positives = 114/289 (39%), Gaps = 49/289 (16%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG-TCSLHIESTTSDDDGNY 1017
G+ T +C++ +V W+KDGK++S + K+R E G T L ++ D G Y
Sbjct: 1549 GTSATLSCEVAQAQT-EVTWYKDGKKLSSSS---KVRMEAVGCTRRLVVQEAGQADAGEY 1604
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
+ A + + S HL H +V ++P
Sbjct: 1605 SCKAGDQR----LSFHL-----------------HVAEPKVVFAKEQP------------ 1631
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG-VHSLLIDPL 1136
A ++ A G L C+V+ E+TW +G+ + +S K+ V G L++
Sbjct: 1632 AHREVQAEAGASATLSCEVA-QAQTEVTWYKDGKKL--SSSSKVRVEAVGCTRRLVVQQA 1688
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
Q DAG Y C A + + SF L ++ + ++ + P E L V E + L +
Sbjct: 1689 GQADAGEYSCEAGGQ--RLSFRLHVAELEPQISERPCRREPLV---VKEHEDIILTATLA 1743
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
W KD I ++ + Q T L + A+ D+ Y+
Sbjct: 1744 TPSAATVTWLKDGVEIRRSKRHETASQGDT--HTLTVHGAQVLDSAIYS 1790
Score = 47.4 bits (111), Expect = 9e-05
Identities = 68/304 (22%), Positives = 117/304 (38%), Gaps = 43/304 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P RF + ++++E EG L C + P V W + L + + Q G L
Sbjct: 3537 PARFIEDVKNQEAREGATAVLQCELNSAAP--VEWRKGSETLRDGDRYSLRQDGTKCELQ 3594
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-----------EMN 376
I DTG YSC + G + TSA + + + +EG N+E E++
Sbjct: 3595 IRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCELS 3650
Query: 377 RIQ-----KPNEVSSPPTTSAVIPPAVP---QAQHLVAQPRVATIQQC-QSPTNYLQGLD 427
++ K +E ++ Q + LVA+ + C + T+ + +
Sbjct: 3651 KMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLTVR 3710
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTLIEDSPDFRILQK 486
P F + L+N A+EG C + K AP VEW + + D + Q
Sbjct: 3711 AMP----SKFIEGLRNEEATEGDTATLWCELSKAAP---VEWRKGHETLRDGDRHSLRQD 3763
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS-SIAQLHVRGNEDLSNNGSLH 545
R C L I + D+G ++C + + + ++ L R ED+ N +
Sbjct: 3764 GSR--------CELQIRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEARE 3815
Query: 546 SANS 549
A +
Sbjct: 3816 GATA 3819
Score = 47.0 bits (110), Expect = 1e-04
Identities = 75/310 (24%), Positives = 117/310 (37%), Gaps = 72/310 (23%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLHIESTTSDD 1013
R G+ T +C++ +V W+KDGK++S + K+R E G L ++ D
Sbjct: 1269 RTEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSS---KVRIEAAGCMRQLVVQQAGQAD 1324
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G YT A G S HL V + A KE L R
Sbjct: 1325 AGEYTCEA----GGQRLSFHLDVS----EPKAVFA--------------KEQLAHR---- 1358
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG-VHSLL 1132
+ A G + L C+V+ E+TW +G+ + +S K+ + G L+
Sbjct: 1359 -------KVQAEAGAIATLSCEVA-QAQTEVTWYKDGKKL--SSSSKVRMEAVGCTRRLV 1408
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ Q D G Y C A + + SFSL+++ K + ++Q G L
Sbjct: 1409 VQQACQADTGEYSCEAGGQ--RLSFSLDVAEPKVVFAKEQPVHREVQ---AQAGASTTLS 1463
Query: 1193 CRVIGMPPPVFYWKKDN-----------ETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
C V V W KD E + CTR L++Q A ++ A
Sbjct: 1464 CEVAQAQTEVM-WYKDGKKLSFSSKVRMEAVGCTRR-------------LVVQQAGQAVA 1509
Query: 1242 GWYTLSAKNE 1251
G Y+ A ++
Sbjct: 1510 GEYSCEAGSQ 1519
Score = 46.6 bits (109), Expect = 2e-04
Identities = 67/321 (20%), Positives = 120/321 (37%), Gaps = 43/321 (13%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKL----RSREVPEG 283
+E RR Q A +A G+ + + L + + +P K R + G
Sbjct: 1582 MEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAG 1641
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
L C V +V WY +GK+L +S + + G L + +A + D G YSC A
Sbjct: 1642 ASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Query: 344 SNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE----VSSPPTTSAVIPPAVP 399
G S +++ + SE +E + + K +E ++ T SA +
Sbjct: 1701 ----GGQRLSFRLHVAELEPQISERPCRREPL--VVKEHEDIILTATLATPSAATVTWLK 1754
Query: 400 QAQHLVAQPRVATIQQCQSPTNYLQG---LDGK-------------PIIAAPV---FTKM 440
+ R T Q + T + G LD P+ V F ++
Sbjct: 1755 DGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRL 1814
Query: 441 LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTL 500
L+ + G V C + A +V W T + F+++ + P + +L
Sbjct: 1815 LEPVCGELGGTVTLACELSPA-CAEVVWRCGNTQLRVGKRFQMVAEGP--------VRSL 1865
Query: 501 VIAEVFAEDSGCFTCTASNKY 521
+ + AED+G + C + + +
Sbjct: 1866 TVLGLRAEDAGEYVCESRDDH 1886
Score = 46.6 bits (109), Expect = 2e-04
Identities = 76/335 (22%), Positives = 129/335 (38%), Gaps = 67/335 (20%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQ-PPRFTQKLRSRE---VPEGTRVQLDC 290
RR Q A +A G+ + + L + + + P+ +++ RE V E + L
Sbjct: 1681 RRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRREPLVVKEHEDIILTA 1740
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
+ V W +G E+ S G+ H+LT+ A D+ YSC G +
Sbjct: 1741 TLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRV----GAE 1796
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKP--NEVSSPPTTSAVIPPA----------- 397
+ +E V++ + R+ +P E+ T + + PA
Sbjct: 1797 GQDFPVQVEEVAA----------KFCRLLEPVCGELGGTVTLACELSPACAEVVWRCGNT 1846
Query: 398 ---VPQAQHLVAQPRVATIQQ------------CQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
V + +VA+ V ++ C+S ++ + ++ P K +
Sbjct: 1847 QLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSA---QLTVSVPRVVKFMS 1903
Query: 443 NLS---ASEGQLVVFECRVKGAPSP-KVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
LS A EG F+C V +PS V W+R+G L++ S F I Q
Sbjct: 1904 GLSTVVAEEGGEATFQCVV--SPSDVAVVWFRDGALLQPSEKFAISQSGASH-------- 1953
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+L I+++ ED+G T A SS A L VR
Sbjct: 1954 SLTISDLVLEDAGQITVEAEG----ASSSAALRVR 1984
Score = 46.2 bits (108), Expect = 2e-04
Identities = 74/331 (22%), Positives = 119/331 (35%), Gaps = 63/331 (19%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSR----EVPEG 283
+E RR Q A +A G+ + + L + + +P K + + G
Sbjct: 938 MEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAG 997
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
L C V +V WY +GK+L +S +H+ G L + +A + D G YSC A
Sbjct: 998 ASATLSCEVAQAQT-EVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA 1056
Query: 344 SNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQ- 402
S ++I +P NEV + SA++ V QAQ
Sbjct: 1057 RG----QRVSFRLHIT---------EPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT 1103
Query: 403 ---------HLVAQPRVA-TIQQC-----------QSPTNYLQGLDGKPI-----IAAP- 435
L + +V ++ C Y G+ + I P
Sbjct: 1104 EVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPK 1163
Query: 436 -VFTK---MLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
VF K + + A G + C V P +V WY++G + S R+ K
Sbjct: 1164 GVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKG---- 1218
Query: 492 AEPEEICT--LVIAEVFAEDSGCFTCTASNK 520
CT LV+ +V D+G ++C A +
Sbjct: 1219 ------CTRRLVVQQVGKADAGEYSCEAGGQ 1243
Score = 45.8 bits (107), Expect = 3e-04
Identities = 68/292 (23%), Positives = 112/292 (38%), Gaps = 50/292 (17%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG-TCSLHIESTTSDDDGNY 1017
G+ +C++ P +V W+KDGK++S + K+R E G T L ++ D G Y
Sbjct: 1181 GTTAMLSCEVAQ-PQTEVTWYKDGKKLSSSS---KVRMEVKGCTRRLVVQQVGKADAGEY 1236
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
+ A R+S H+ KE L R
Sbjct: 1237 SCEAGGQ--RVSFQLHITEPKAVFA--------------------KEQLVHNEVR----- 1269
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG-VHSLLIDPL 1136
G L C+V+ E+TW +G+ + +S K+ + G + L++
Sbjct: 1270 ------TEAGASATLSCEVA-QAQTEVTWYKDGKKL--SSSSKVRIEAAGCMRQLVVQQA 1320
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
Q DAG Y C A + + SF L++S K + K+Q G L C V
Sbjct: 1321 GQADAGEYTCEAGGQ--RLSFHLDVSEPKAVFAKEQLAHRKVQ---AEAGAIATLSCEVA 1375
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
V ++K + ++ R+ T L++Q A ++D G Y+ A
Sbjct: 1376 QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR---LVVQQACQADTGEYSCEA 1424
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/107 (28%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P RF + L+ EV EG L C++ + P V+W L + Q G + L
Sbjct: 3183 RPVRFQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQEGAMLEL 3241
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
+ +D+GRYSC +G +TSA + + + + NKE
Sbjct: 3242 VVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKLRNKE 3284
Score = 44.7 bits (104), Expect = 6e-04
Identities = 91/388 (23%), Positives = 141/388 (36%), Gaps = 63/388 (16%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIH-IVQAGNLHSL 326
P +FT+ LR+ E EG L C + + P V W+ +G E D H + Q G L
Sbjct: 3625 PIKFTEGLRNEEATEGATAVLRCELSKMAP--VEWW-KGHETLRDGDRHSLRQDGARCEL 3681
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I ED G Y C G + TSA + + + S EG N+E + + +
Sbjct: 3682 QIRGLVAEDAGEYLCMC----GKERTSAMLTVRAMPSKFIEGLRNEE----ATEGDTATL 3733
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQ----CQSPTNYLQGLD--------GKPIIAA 434
S P + + +++Q C+ L +D G+ +A
Sbjct: 3734 WCELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSA 3793
Query: 435 PV--------FTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTLIEDSPDFRILQ 485
+ F + ++N A EG V +C + K AP VEW + + + + Q
Sbjct: 3794 TLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQ 3850
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNN--GS 543
R C L I + D+G ++C G + A L VR + + S
Sbjct: 3851 DGTR--------CELQIHGLSVADTGEYSCVC----GQERTSATLTVRAPQPVFREPLQS 3898
Query: 544 LHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLP 603
L + +T E SEP + K L+ EPR V +L
Sbjct: 3899 LQAEEGSTATLQCE------LSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQ 3952
Query: 604 EDDK-------GSEASSEAGVVTTRQTR 624
+D GS+A+S VT R
Sbjct: 3953 REDTGEYTCTCGSQATSATLTVTAAPVR 3980
Score = 43.5 bits (101), Expect = 0.001
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 18/172 (10%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
++ A G L C+V+ P E+TW +G+ + + +M V+ L++ + + D
Sbjct: 1175 EVQAEAGTTAMLSCEVAQ-PQTEVTWYKDGKKLSSSSKVRMEVKGC-TRRLVVQQVGKAD 1232
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
AG Y C A + + SF L ++ K ++ +++ G L C V
Sbjct: 1233 AGEYSCEAGGQ--RVSFQLHITEPKAVFAKEQLVHNEVRT---EAGASATLSCEVAQAQT 1287
Query: 1201 PVFYWKKDNETIPCTRERIS----MHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
V ++K + ++ RI M Q L++Q A ++DAG YT A
Sbjct: 1288 EVTWYKDGKKLSSSSKVRIEAAGCMRQ-------LVVQQAGQADAGEYTCEA 1332
Score = 43.5 bits (101), Expect = 0.001
Identities = 54/241 (22%), Positives = 88/241 (36%), Gaps = 40/241 (16%)
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS--- 353
P V+WY + L S + G + L I D G Y C A + + + +
Sbjct: 2496 PKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEA 2555
Query: 354 -----------AEIYIEGVSSSDSEGDPNKEE----MNRIQKPN----EVSSPPTTSAVI 394
AE EG +S E EE +N + N E+S ++
Sbjct: 2556 REVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLV 2615
Query: 395 PPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
++ +A + + + T+ + KP+ VF K L +LSA E +
Sbjct: 2616 LKSIQRADAGIVRASSLKVS-----TSARLEVRVKPV----VFLKALDDLSAEERGTLAL 2666
Query: 455 ECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFT 514
+C V P V W ++G + S + L LV+ +V ED+G +T
Sbjct: 2667 QCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTAGTR--------GLVVHDVSPEDAGLYT 2717
Query: 515 C 515
C
Sbjct: 2718 C 2718
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/113 (26%), Positives = 46/113 (40%), Gaps = 26/113 (23%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQ---------------ISK 987
+ P +R +V +GS +TF+ K+ G PVP V+W ++ + S
Sbjct: 5369 VPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 988 RNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+H SL + G YT +A+N G+ CS L V LP
Sbjct: 5429 AQQH-----------SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLP 5470
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 16/129 (12%)
Query: 243 SEAAGGDTTPGSSPSSLYY-----------EEPLGQPPRFTQKLRSREVPEGTRVQLDCI 291
S+AA + PG+S ++L E PP + R+ V EG +L C
Sbjct: 203 SDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP--STGTRTCTVTEGKHARLSCY 260
Query: 292 VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAF--EEDTGRYSCFASNIYGT 349
V G P P+ W +G +L H+V + + F + D G Y+C ASN+ G
Sbjct: 261 VTGEPKPETVWKKDG-QLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQ 319
Query: 350 DSTSAEIYI 358
+S + +
Sbjct: 320 TYSSVLVVV 328
Score = 40.8 bits (94), Expect = 0.009
Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 8/107 (7%)
Query: 426 LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQ 485
+D AP F + S G+ C++ G P+P+V W ++ + FR
Sbjct: 1 MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFR--- 57
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+A+ ++ L I ++ DSG + C A N G + L V
Sbjct: 58 -----LAQDGDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQV 99
Score = 40.8 bits (94), Expect = 0.009
Identities = 72/323 (22%), Positives = 117/323 (36%), Gaps = 47/323 (14%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKL----RSREVPEG 283
+E RR Q A +A G+ + + L + + +P K R + G
Sbjct: 1398 MEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAG 1457
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
L C V +V WY +GK+L S + + G L + +A + G YSC A
Sbjct: 1458 ASTTLSCEVAQAQT-EVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA 1516
Query: 344 SNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNR------------IQKPNEVS------ 385
G+ S +++ + ++ P E+ Q EV+
Sbjct: 1517 ----GSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGK 1572
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAP--VFTK---M 440
++S V AV + LV Q S Q L +A P VF K
Sbjct: 1573 KLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPA 1632
Query: 441 LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI-CT 499
+ + A G C V A + +V WY++G + S R+ E + CT
Sbjct: 1633 HREVQAEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRV-----------EAVGCT 1680
Query: 500 --LVIAEVFAEDSGCFTCTASNK 520
LV+ + D+G ++C A +
Sbjct: 1681 RRLVVQQAGQADAGEYSCEAGGQ 1703
Score = 40.4 bits (93), Expect = 0.011
Identities = 69/310 (22%), Positives = 118/310 (38%), Gaps = 58/310 (18%)
Query: 949 KRLKHFRVTE--GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG-TCSLH 1005
++L H +V G+ T +C++ +V W+KDGK++S + K+R E G T L
Sbjct: 1353 EQLAHRKVQAEAGAIATLSCEVAQAQT-EVTWYKDGKKLSSSS---KVRMEAVGCTRRLV 1408
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
++ D G Y+ A G + SL + +V ++P
Sbjct: 1409 VQQACQADTGEYSCEA---------GGQRLSFSLDV------------AEPKVVFAKEQP 1447
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
+ ++ A G L C+V+ E+ W +G+ + S K+ +
Sbjct: 1448 VHR------------EVQAQAGASTTLSCEVA-QAQTEVMWYKDGKKL--SFSSKVRMEA 1492
Query: 1126 TG-VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV---AKEVKKAPVILEKLQNC 1181
G L++ Q AG Y C + G S L V A K+ P E
Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSC----EAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEA 1548
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
G L C V V ++K + ++ R+ T L++Q A ++DA
Sbjct: 1549 GT----SATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR---LVVQEAGQADA 1601
Query: 1242 GWYTLSAKNE 1251
G Y+ A ++
Sbjct: 1602 GEYSCKAGDQ 1611
Score = 39.7 bits (91), Expect = 0.019
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 8/114 (7%)
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC 1230
AP L + + V G L C+++G P P W+KD + + R + QD Y
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV-AAGARFRLAQDGDLYRL 67
Query: 1231 LLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYA------QWHHQIPPPMSVR 1278
++ A D+G Y A+N G L + A Q H + P S+R
Sbjct: 68 TILDLA-LGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIR 120
Score = 38.9 bits (89), Expect = 0.033
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 9/90 (10%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
S P ++ +E L + R + G L C V +V WY +GK+L +S
Sbjct: 884 SEPKVVFAKEQLAR--------RKLQAEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSS 934
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
+ + G L + +A + D G YSC A
Sbjct: 935 KVCMEATGCTRRLVVQQAGQADAGEYSCEA 964
Score = 38.5 bits (88), Expect = 0.043
Identities = 63/297 (21%), Positives = 102/297 (34%), Gaps = 53/297 (17%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P RF ++L+ +EV EG L C + V W +L +VQ G L
Sbjct: 3978 PVRFLRELQHQEVDEGGTAHL-CCELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELL 4036
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS- 386
+ +ED G Y+C + S S + P + R+Q + +
Sbjct: 4037 VRGVEQEDAGDYTCDTGHTQSMASLSVRV-------------PRPKFKTRLQSLEQETGD 4083
Query: 387 --------PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI------- 431
S + + + L A P+ Q + + L+ K
Sbjct: 4084 IARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYACVT 4143
Query: 432 ----------IAAPVFT--KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ P T + L + + + V F C V A + V+W +G ++ +
Sbjct: 4144 GGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQSNE 4203
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ + R I TL + V ED+G T S G +S AQL VR E
Sbjct: 4204 VTEVAVRDGR-------IHTLRLKGVTPEDAG----TVSFHLGNHASSAQLTVRAPE 4249
Score = 38.1 bits (87), Expect = 0.056
Identities = 40/147 (27%), Positives = 64/147 (43%), Gaps = 16/147 (10%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGV-HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
W +G L + + L + G H L+ +T++D GTY C + G++S L V
Sbjct: 830 WYKDGME-LGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSC----RVGEDSVDFRLRVS 884
Query: 1165 AKEV--KKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+V K + KLQ G L C V V W KD + + + + +
Sbjct: 885 EPKVVFAKEQLARRKLQ---AEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSK---VC 937
Query: 1223 QDTTGYA-CLLIQPAKKSDAGWYTLSA 1248
+ TG L++Q A ++DAG Y+ A
Sbjct: 938 MEATGCTRRLVVQQAGQADAGEYSCEA 964
Score = 38.1 bits (87), Expect = 0.056
Identities = 66/319 (20%), Positives = 118/319 (36%), Gaps = 41/319 (12%)
Query: 225 NHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGT 284
+H+L + +A Q EA G SS ++L E P F +KL + V E +
Sbjct: 1952 SHSLTISDLVLEDAGQITVEAEGA-----SSSAALRVREA---PVLFKKKLEPQTVEERS 2003
Query: 285 RVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
V L+ + + P P++RW L ++ I G H L + D G + C
Sbjct: 2004 SVTLE-VELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETP 2062
Query: 345 NIYGTDSTSAEIYIE--------GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP 396
+ D T A++ +E G+ + ++ + M +V T +
Sbjct: 2063 D----DKTQAKLTVEMRQVRLVRGLQAVEAR-EQGTATMEVQLSHADVDGSWTRDGLRFQ 2117
Query: 397 AVPQAQHLVAQP-RVATIQQCQSPTNYLQGLDGKPIIAA--------PV-FTKMLQNLSA 446
P V P T+ + + L + + + PV F++ LQ++
Sbjct: 2118 QGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVT 2177
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
+E + V EC + P+ V W ++G + K ++A +L I
Sbjct: 2178 TEKEKVTLECEL-SRPNVDVRWLKDGV--------ELRAGKTMAIAAQGACRSLTIYRCE 2228
Query: 507 AEDSGCFTCTASNKYGTVS 525
D G + C A + + S
Sbjct: 2229 FADQGVYVCDAHDAQSSAS 2247
Score = 38.1 bits (87), Expect = 0.056
Identities = 50/245 (20%), Positives = 92/245 (37%), Gaps = 41/245 (16%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S +SL E +P + L + V G V+L C + P V W + K + S
Sbjct: 2815 TSKASLIVRE---RPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQ 2870
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
+V G + L I A +D G Y+C ++A +++E + + E
Sbjct: 2871 KYDVVCEGTMAMLVIRGASLKDAGEYTCEVE----ASKSTASLHVE------EKANCFTE 2920
Query: 374 EMNRIQKPNEVSSPPTTSAVIPPAV-----------------PQAQHLVAQPRVATIQQC 416
E+ +Q + ++ T P A P + L + ++ +++
Sbjct: 2921 ELTNLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKA 2980
Query: 417 QSPTNYLQGLDGKPIIAAPVFT--------KMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
S T Y + G+ A + + L+++ EG F CR+ A V W
Sbjct: 2981 DSDT-YTCDI-GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHW 3038
Query: 469 YREGT 473
+ + T
Sbjct: 3039 FLDKT 3043
Score = 38.1 bits (87), Expect = 0.056
Identities = 70/316 (22%), Positives = 113/316 (35%), Gaps = 67/316 (21%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +F KLR++E EG L C + P V W + L + + Q G + L
Sbjct: 3273 PAQFIGKLRNKEATEGATATLRCELSKAAP--VEWRKGSETLRDGDRYCLRQDGAMCELQ 3330
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV-SS 386
I D YSC + G + TSA + I + + + R++ + +
Sbjct: 3331 IRGLAMVDAAEYSC----VCGEERTSASLTIRPMPA---------HFIGRLRHQESIEGA 3377
Query: 387 PPTTSAVIPPAVPQA------------QHLVAQP-RVATIQQC----------------- 416
T + A P +H + Q V +Q C
Sbjct: 3378 TATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEE 3437
Query: 417 -QSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTL 474
S T ++ L K FT+ L+N A EG + C + K AP VEW +
Sbjct: 3438 RTSATLTVKALPAK-------FTEGLRNEEAVEGATAMLWCELSKVAP---VEWRKGPEN 3487
Query: 475 IEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS-SIAQLHVR 533
+ D + + Q+ R C L I + D+G + C + + + +I L R
Sbjct: 3488 LRDGDRYILRQEGTR--------CELQICGLAMADAGEYLCVCGQERTSATLTIRALPAR 3539
Query: 534 GNEDLSNNGSLHSANS 549
ED+ N + A +
Sbjct: 3540 FIEDVKNQEAREGATA 3555
Score = 37.7 bits (86), Expect = 0.073
Identities = 33/143 (23%), Positives = 65/143 (45%), Gaps = 11/143 (7%)
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
+TWL +G+ + P +++ G LL+ + + DAG Y+C+ ++ G+ ++ L +
Sbjct: 737 VTWLKDGRTLSPGPKYEVQA-SAGRRVLLVRDVARDDAGLYECV--SRGGRIAYQLSVQG 793
Query: 1164 VAKEVKKAPVILEKLQNC-GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+A+ + K + +C G P + EC V +W KD + + ER +
Sbjct: 794 LARFLHK-----DMAGSCVDAVAGGPAQFECETSEAHVHV-HWYKDGMELGHSGERF-LQ 846
Query: 1223 QDTTGYACLLIQPAKKSDAGWYT 1245
+D L+ + D G Y+
Sbjct: 847 EDVGTRHRLVAATVTRQDEGTYS 869
Score = 37.0 bits (84), Expect = 0.13
Identities = 79/389 (20%), Positives = 142/389 (36%), Gaps = 45/389 (11%)
Query: 167 SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFS-DLS---ERRERSSVPIPIPADTRDN 222
+HSS + A + + + +E +SFS +LS E E S +P+ D+ +
Sbjct: 2545 AHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLYNDSF-H 2603
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E++H + + ++A + + S+ + L E +P F + L E
Sbjct: 2604 EISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARL---EVRVKPVVFLKALDDLSAEE 2660
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
+ L C V P V W +G +L S + L + + ED G Y+C
Sbjct: 2661 RGTLALQC-EVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCH 2719
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMN------RIQKPNEVSSPPTT------ 390
G++ T A + + + ++ E + +E +S P
Sbjct: 2720 V----GSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGK 2775
Query: 391 ---SAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAA----PVFTKMLQN 443
S+ A Q + + R A ++GL K + K L++
Sbjct: 2776 TVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLED 2835
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ G+ V C + A +P V W ++ I S + ++ + +M LVI
Sbjct: 2836 QWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEGTMAM--------LVIR 2886
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+D+G +TC S A LHV
Sbjct: 2887 GASLKDAGEYTCEVE----ASKSTASLHV 2911
Score = 36.6 bits (83), Expect = 0.16
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P F+++L + EG + L C P V W +GK L S + G+ L
Sbjct: 3094 KPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDGKTLRGSARCQLSHEGHRAQL 3152
Query: 327 TIAEAFEEDTGRYSCFA 343
I A +D+GRY C A
Sbjct: 3153 LITGATLQDSGRYKCEA 3169
Score = 35.0 bits (79), Expect = 0.48
Identities = 42/169 (24%), Positives = 73/169 (43%), Gaps = 11/169 (6%)
Query: 1084 AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV-HSLLIDPLTQRDAG 1142
A EG +C++S TWLL+ +PV + +++ E G+ H LL+ L +D+
Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDS- 4409
Query: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI-GMPPP 1201
C T G S L+V ++ ILE L+N V G C + +P
Sbjct: 4410 ---CRVTFLAGDMVTSAFLTVRGWRLE----ILEPLKNAAVRAGAQACFTCTLSEAVPVG 4462
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
W + + ++ D + +A LL++ A+ AG T + ++
Sbjct: 4463 EASWYINGAAVQPDDSDWTVTADGSHHA-LLLRSAQPHHAGEVTFACRD 4510
Score = 34.3 bits (77), Expect = 0.81
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 3/98 (3%)
Query: 1164 VAKEVKK--APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
V KE+K+ P+ + G +RLEC V W KD + R +
Sbjct: 4888 VRKEMKQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHH-HI 4946
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTA 1259
Q G LLI ++DAG YT N+ G V+ +A
Sbjct: 4947 DQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSA 4984
Score = 33.5 bits (75), Expect = 1.4
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 5/73 (6%)
Query: 278 REVPEGTRVQLD-----CIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAF 332
R++P T V++ C+ + +P V W +E+ + I G H+LTI++
Sbjct: 424 RKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCC 483
Query: 333 EEDTGRYSCFASN 345
ED G+ + A +
Sbjct: 484 LEDVGQVAFMAGD 496
Score = 33.5 bits (75), Expect = 1.4
Identities = 55/247 (22%), Positives = 90/247 (36%), Gaps = 47/247 (19%)
Query: 300 VRWYCEGKELENSPDIHIVQ-AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
V WY +G EL +S + + + G H L A +D G YSC G DS + +
Sbjct: 828 VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRV----GEDSVDFRLRV 883
Query: 359 EGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ------AQHLVAQPRVA- 411
S+ + KE++ R + E + T S + A + + L + +V
Sbjct: 884 -----SEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCM 938
Query: 412 ---------TIQQ----------CQSPTNYLQ-GLDGK-PIIAAPVFTKMLQNLSASEGQ 450
+QQ C++ L LD K P + + A G
Sbjct: 939 EATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGA 998
Query: 451 LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDS 510
C V A + +V WY++G + S + K R LV+ + D+
Sbjct: 999 SATLSCEVAQAQT-EVMWYKDGKKLSSSLKVHVEAKGCRR--------RLVVQQAGKTDA 1049
Query: 511 GCFTCTA 517
G ++C A
Sbjct: 1050 GDYSCEA 1056
Score = 31.6 bits (70), Expect = 5.3
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVR 1124
L R +R L+ + G C +S +P E +W +NG V PD S +
Sbjct: 4425 LTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTA 4484
Query: 1125 ETGVHSLLIDPLTQRDAG--TYKC 1146
+ H+LL+ AG T+ C
Sbjct: 4485 DGSHHALLLRSAQPHHAGEVTFAC 4508
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/94 (26%), Positives = 35/94 (37%), Gaps = 1/94 (1%)
Query: 248 GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK 307
G P P ++ EP P SR+V G V L+ VV +V W+ +
Sbjct: 4603 GAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVA-EAGEVIWHKGME 4661
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
++ +V G L I ED G Y C
Sbjct: 4662 RIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHC 4695
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 113 bits (282), Expect = 1e-24
Identities = 93/348 (26%), Positives = 146/348 (41%), Gaps = 34/348 (9%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP+F L++ V +G PV+F C + G P+P V WFKDGK + + ++H + + G
Sbjct: 5125 APVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGK-LLEEDDHYMINEDQQGGHQ 5183
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ----SLPIRSRLTSAGQSHRGRSRVQ 1059
L I + D G Y +A N G S L V + T + + +
Sbjct: 5184 LIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLS 5243
Query: 1060 ERDKEPLQERFFRPHFLQAPGDM----VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLP 1115
R++E + Q ++ VA RL + KV G P P L W +GQP+
Sbjct: 5244 SREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTA 5303
Query: 1116 DASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---------VAK 1166
A +M ++ +H+L I +T+ D+G Y +N G S L V A
Sbjct: 5304 SAHIRMTDKKI-LHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPAS 5362
Query: 1167 EVKK---APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQ 1223
+V + P +LE+ V +G + +V G P P +W ++ R + +
Sbjct: 5363 DVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREE----AERGVLWIGP 5418
Query: 1224 DTTGYA--------CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
DT GY L++ + G YT A N AG C+A L +
Sbjct: 5419 DTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 5466
Score = 101 bits (251), Expect = 5e-21
Identities = 96/339 (28%), Positives = 131/339 (38%), Gaps = 58/339 (17%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F R K F V+ G T +C+IVG P P+V W KD + ++ ++ ++GD
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAA-GARFRLAQDGD-LYR 66
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I D G Y A N G + L V + A Q+
Sbjct: 67 LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDA-----EAACAEQA------------ 109
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
PHFL P + EG C+V G P P ++W +G+ + ++ V
Sbjct: 110 ---------PHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRV 160
Query: 1124 RETGVHSLL-IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP-------VIL 1175
E G S L I RD GTY+ A N G S + L V + A +L
Sbjct: 161 EELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALL 220
Query: 1176 EKLQN---------------------CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPC 1214
LQ C V EG RL C V G P P WKKD + +
Sbjct: 221 AHLQRRREAMRAEGAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTE 280
Query: 1215 TRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
R + +++D L I K+SD G YT +A N G
Sbjct: 281 GRRHV-VYEDAQENFVLKILFCKQSDRGLYTCTASNLVG 318
Score = 98.6 bits (244), Expect = 4e-20
Identities = 86/305 (28%), Positives = 134/305 (43%), Gaps = 48/305 (15%)
Query: 236 REAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
R E S+ P SL + P F +L+++EV +G V DC+V G
Sbjct: 5096 RRVEMCISKETPAPVVPPEPLPSLLTSDAA---PVFLTELQNQEVQDGYPVSFDCVVTGQ 5152
Query: 296 PPPQVRWYCEGKELENSPD--IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
P P VRW+ +GK LE I+ Q G H L I D G Y C A N G ST
Sbjct: 5153 PMPSVRWFKDGKLLEEDDHYMINEDQQGG-HQLIITAVVPADMGVYRCLAENSMGVSSTK 5211
Query: 354 AEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATI 413
AE+ ++ ++S+D + T+A A + + AQ +++
Sbjct: 5212 AELRVD-LTSTDYD----------------------TAA---DATESSSYFSAQGYLSSR 5245
Query: 414 QQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEG-QLVVFECRVKGAPSPKVEWYREG 472
+Q + + +G P + L++L + G +L F+ +VKG P+P++ W+++G
Sbjct: 5246 EQEGTESTTDEG-------QLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDG 5298
Query: 473 TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ S R+ KK + TL I V EDSG + SN G S A+L V
Sbjct: 5299 QPLTASAHIRMTDKK--------ILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLV 5350
Query: 533 RGNED 537
RG ++
Sbjct: 5351 RGPDE 5355
Score = 88.2 bits (217), Expect = 5e-17
Identities = 90/354 (25%), Positives = 140/354 (39%), Gaps = 75/354 (21%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGN-LHSLT 327
P F+ E G ++L+C+V + RW +G EL + HI Q G+ SL
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLL 4957
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-------------E 374
I D G Y+C SN +G + SA + + G S S++E E
Sbjct: 4958 ITGLDRADAGCYTCQVSNKFGQVTHSACVVVSG-SESEAESSSGGELDDAFRRAARRLHR 5016
Query: 375 MNRIQKPNEVSSPPT-TSAVIPPAVPQA----------QHLVAQPRVATIQQCQSPTNYL 423
+ R + P EVS SA PA P+ +H + A + Q+ T +
Sbjct: 5017 LFRTKSPAEVSDEELFLSADEGPAEPEEPADWQTYREDEHFICIRFEALTEARQAVTRFQ 5076
Query: 424 Q-------GLDGK-------------------PII------------AAPVFTKMLQNLS 445
+ G++ K P++ AAPVF LQN
Sbjct: 5077 EMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQE 5136
Query: 446 ASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEV 505
+G V F+C V G P P V W+++G L+E+ + I + + L+I V
Sbjct: 5137 VQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGH-------QLIITAV 5189
Query: 506 FAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQ 559
D G + C A N G S+ A+L V DL++ +A++T + + Q
Sbjct: 5190 VPADMGVYRCLAENSMGVSSTKAELRV----DLTSTDYDTAADATESSSYFSAQ 5239
Score = 87.8 bits (216), Expect = 6e-17
Identities = 78/256 (30%), Positives = 110/256 (42%), Gaps = 12/256 (4%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F R RV EGS TF C++ G P P V W KDG+++ + + E +
Sbjct: 109 APHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASA 168
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + D G Y + A NP G S + L+V S + G S +R +
Sbjct: 169 LRIRAARPRDGGTYEVRAENPLGAASAAAALVVDS-DAADTASRPGTSTAALLAHLQRRR 227
Query: 1064 EPLQERFFRPHFLQAPG--DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
E ++ P + G EG+ RL C V+G P PE W +GQ V H
Sbjct: 228 EAMRAE-GAPASPPSTGTRTCTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRH-- 284
Query: 1122 LVRETGVHSLLIDPL--TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ 1179
+V E + ++ L Q D G Y C A+N GQ ++S L VV + A ++LQ
Sbjct: 285 VVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQ-TYSSVLVVVR---EPAVPFKKRLQ 340
Query: 1180 NCGVPEGHPVRLECRV 1195
+ V E C V
Sbjct: 341 DLEVREKESATFLCEV 356
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/191 (27%), Positives = 85/191 (44%), Gaps = 5/191 (2%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P F + D A G +L C+V+G P P ++W +G+ V D H ++ G +L+
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+D LT D+G Y C A + G S ++ V+ P + K++ EG +
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKIL-----VQVPPRFVNKVRASPFVEGEDAQFT 6128
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C + G P P W KD + + ++ + +G L+I+ A K D G Y N
Sbjct: 6129 CTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRL 6188
Query: 1253 GIVSCTARLDI 1263
G +A L I
Sbjct: 6189 GSARASAELRI 6199
Score = 80.9 bits (198), Expect = 8e-15
Identities = 57/191 (29%), Positives = 86/191 (45%), Gaps = 3/191 (1%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P FL P V G+ L C++ G P P+++W + QPV A + L ++ ++ L
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFR-LAQDGDLYRLT 68
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKE--VKKAPVILEKLQNCGVPEGHPVR 1190
I L D+G Y C A N G+ ++ L V A+ ++AP L + + V EG
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEAT 128
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
CRV G P P W KD + ++ + L I+ A+ D G Y + A+N
Sbjct: 129 FRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAEN 188
Query: 1251 EAGIVSCTARL 1261
G S A L
Sbjct: 189 PLGAASAAAAL 199
Score = 79.0 bits (193), Expect = 3e-14
Identities = 66/276 (23%), Positives = 107/276 (38%), Gaps = 71/276 (25%)
Query: 266 GQPPRFTQKLRSREVPEGTRV-QLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
GQ P+ ++LR +V GTR+ + V G P P++ W+ +G+ L S I + LH
Sbjct: 5257 GQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQPLTASAHIRMTDKKILH 5316
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
+L I ED+G+Y+ + SN G +SA + + G +P E
Sbjct: 5317 TLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPD-----------------EPEEK 5359
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
+ ++PP + L+ K +
Sbjct: 5360 PASDVHEQLVPPRM------------------------LERFTPKKV------------- 5382
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGT------LIEDSPDFRILQKKPRSMAEPEEIC 498
+G + F +V+G P P V W RE + D+P + + A +
Sbjct: 5383 --KKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTV--------ASSAQQH 5432
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+LV+ +V + G +TC ASN G A LHV G
Sbjct: 5433 SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468
Score = 79.0 bits (193), Expect = 3e-14
Identities = 54/220 (24%), Positives = 86/220 (39%), Gaps = 35/220 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F++ L G V C++ G P P + W+KDGK + H + + DG+C+L
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHI-LIEDPDGSCAL 6072
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
++S T D G Y AA+ G S G ++VQ
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ--------------------------- 6105
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
P F+ EG + C + G P P++ W +G + + L
Sbjct: 6106 ------VPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSE 6159
Query: 1125 -ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
+G+ L+I ++ D G Y+C N+ G S EL +
Sbjct: 6160 PRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 70.5 bits (171), Expect = 1e-11
Identities = 81/347 (23%), Positives = 136/347 (39%), Gaps = 36/347 (10%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F +++ EG FTC I G P P++ W+KDG ++ N+ + G
Sbjct: 6106 VPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLL 6165
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGR------- 1055
L I + + +D G Y N G S L +QS L + Q HR +
Sbjct: 6166 VLVIRAASKEDLGLYECELVNRLGSARASAELRIQS----PMLQAQEQCHREQLVAAVED 6221
Query: 1056 SRVQERDKE--PLQERFFRPHF-------LQAPGDMVAHEGRLCRLDCK--VSGLPPPEL 1104
+ ++ D+E + +R P L PG L + V+G
Sbjct: 6222 TTLERADQEVTSVLKRLLGPKAPGPSTGDLTGPGPCPRGAPALQETGSQPPVTGTSEAPA 6281
Query: 1105 TWLLNGQPVL---PDASHKMLVR-ETGVHSLLIDPLTQRDAGTYKCI------ATNKTGQ 1154
QP+L P+ + + R + + ++ AGT + + +T Q
Sbjct: 6282 VPPRVPQPLLHEGPEQEPEAIARAQEWTVPIRMEGAAWPGAGTGELLWDVHSHVVRETTQ 6341
Query: 1155 NSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPC 1214
+++ + + + P + +++ G + E + G P P W KD+ +
Sbjct: 6342 RTYTYQ--AIDTHTARPPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQL-V 6398
Query: 1215 TRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
R+S Q+ T Y+ +L A K DAG YT A+N G V C A L
Sbjct: 6399 DSTRLSQQQEGTTYSLVLRHVASK-DAGVYTCLAQNTGGQVLCKAEL 6444
Score = 66.2 bits (160), Expect = 2e-10
Identities = 67/269 (24%), Positives = 106/269 (39%), Gaps = 49/269 (18%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLH 324
Q P F + S V EG+ C V G P P V W +G+ L + P + + + G
Sbjct: 108 QAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEAS 167
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
+L I A D G Y A N G S +A + ++ SD+ +
Sbjct: 168 ALRIRAARPRDGGTYEVRAENPLGAASAAAALVVD----SDA--------------ADTA 209
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
S P T++A + +A +Q+ + +G P A+P T +
Sbjct: 210 SRPGTSTAAL---------------LAHLQRRREAMR----AEGAP--ASPPSTG-TRTC 247
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
+ +EG+ C V G P P+ W ++G L+ + + + + +E L I
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYE-------DAQENFVLKILF 300
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
D G +TCTASN G S + VR
Sbjct: 301 CKQSDRGLYTCTASNLVGQTYSSVLVVVR 329
Score = 65.9 bits (159), Expect = 3e-10
Identities = 81/317 (25%), Positives = 121/317 (38%), Gaps = 57/317 (17%)
Query: 946 IFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLH 1005
+F + L +TEG +T C+ +P V W KDGK + + + C++ EG L
Sbjct: 3097 VFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDGKTL-RGSARCQLSHEGH-RAQLL 3153
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLM-VQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T D G Y A +CS ++ V + P+R
Sbjct: 3154 ITGATLQDSGRYKCEAGG-----ACSSSIVRVHARPVR---------------------- 3186
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
F +A D+ EG L C +S + P + W G VL L +
Sbjct: 3187 ----------FQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCY-GNNVLRPGDKYSLRQ 3234
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
E + L++ L +D+G Y C G + S L+V A + + KL+N
Sbjct: 3235 EGAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQ----FIGKLRNKEAT 3286
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAKKSDAGW 1243
EG L C + P W+K +ET+ +R + QD G C L I+ DA
Sbjct: 3287 EGATATLRCELSKAAP--VEWRKGSETLR-DGDRYCLRQD--GAMCELQIRGLAMVDAAE 3341
Query: 1244 YTLSAKNEAGIVSCTAR 1260
Y+ E S T R
Sbjct: 3342 YSCVCGEERTSASLTIR 3358
Score = 64.7 bits (156), Expect = 6e-10
Identities = 76/303 (25%), Positives = 122/303 (40%), Gaps = 41/303 (13%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P + LR + E R L+C V QVRW+ +EL+ P +V G L
Sbjct: 2289 PVTLVRPLRDKIAMEKHRGVLEC-QVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLI 2347
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I++ ED Y+C A ++ TSA+ ++E S + G + M P
Sbjct: 2348 ISDVHAEDEDTYTCDAGDV----KTSAQFFVEEQSITIVRGLQDVTVME--PAPAWFECE 2401
Query: 388 PTTSAVIPP------AVPQAQHLVAQPRVATIQQ------CQSPTNYLQGLDGKPIIAA- 434
+ +V PP V QA V + T+ + C + T + GK +A
Sbjct: 2402 TSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSAR 2461
Query: 435 -------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
V T+ L+ + E Q VV C + AP V+WY++ T + S F+
Sbjct: 2462 LVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPK-AVQWYKDDTPLSPSEKFK----- 2515
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSA 547
M+ ++ L I + D+G + C A G+ S ++ V E ++ G L A
Sbjct: 2516 ---MSLEGQMAELRILRLMPADAGVYRCQA----GSAHSSTEVTVEARE-VTVTGPLQDA 2567
Query: 548 NST 550
+T
Sbjct: 2568 EAT 2570
Score = 62.4 bits (150), Expect = 3e-09
Identities = 66/308 (21%), Positives = 106/308 (34%), Gaps = 83/308 (26%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
PRF + ++ V G L C +VG P PQV W + + + + Q G+L+ LTI
Sbjct: 10 PRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLTI 69
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
+ D+G+Y C A N G + + ++ ++
Sbjct: 70 LDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAA------------------------- 104
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
QA H + +P +++
Sbjct: 105 --------CAEQAPHFLLRPTSIRVRE--------------------------------- 123
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLI--EDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
G F CRV G+P P V W ++G + D P R+ E E L I
Sbjct: 124 GSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRV--------EELGEASALRIRAAR 175
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSE 566
D G + A N G S+ A L V + D ++ S ++ LA ++ + +E
Sbjct: 176 PRDGGTYEVRAENPLGAASAAAALVV--DSDAADTASRPGTSTAALLAHLQRRREAMRAE 233
Query: 567 -----PPS 569
PPS
Sbjct: 234 GAPASPPS 241
Score = 61.2 bits (147), Expect = 6e-09
Identities = 76/312 (24%), Positives = 115/312 (36%), Gaps = 54/312 (17%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F + L++ TEG T C++ V W K + + + H +R++G C L I
Sbjct: 3716 FIEGLRNEEATEGDTATLWCELS--KAAPVEWRKGHETLRDGDRH-SLRQDGS-RCELQI 3771
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
D G Y+ + G+ S L V++LP R
Sbjct: 3772 RGLAVVDAGEYSCVC----GQERTSATLTVRALPAR------------------------ 3803
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
F++ + A EG L C++S P E W G L L ++
Sbjct: 3804 --------FIEDVKNQEAREGATAVLQCELSKAAPVE--W-RKGSETLRGGDRYSLRQDG 3852
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
L I L+ D G Y C+ GQ S L+V A + PV E LQ+ EG
Sbjct: 3853 TRCELQIHGLSVADTGEYSCVC----GQERTSATLTVRAPQ----PVFREPLQSLQAEEG 3904
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
L+C + P W K + R Q T A L++Q ++ D G YT
Sbjct: 3905 STATLQCE-LSEPTATVVWSKGGLQLQANGRREPRLQGCT--AELVLQDLQREDTGEYTC 3961
Query: 1247 SAKNEAGIVSCT 1258
+ ++A + T
Sbjct: 3962 TCGSQATSATLT 3973
Score = 60.1 bits (144), Expect = 1e-08
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 7/104 (6%)
Query: 430 PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
P+ P F + L + +A G+ V CRV G P P + WY++G ++ P +++
Sbjct: 6009 PVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIE---- 6064
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+P+ C L++ + DSG + C A++ G S++ ++ V+
Sbjct: 6065 ---DPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ 6105
Score = 60.1 bits (144), Expect = 1e-08
Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 2/94 (2%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQ--AGNLHS 325
PPRF K+R+ EG Q C + G P PQ+RWY +G L + L
Sbjct: 6107 PPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLV 6166
Query: 326 LTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
L I A +ED G Y C N G+ SAE+ I+
Sbjct: 6167 LVIRAASKEDLGLYECELVNRLGSARASAELRIQ 6200
Score = 59.3 bits (142), Expect = 2e-08
Identities = 77/315 (24%), Positives = 121/315 (38%), Gaps = 57/315 (18%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F + L++ TEG+ C++ + V W+K + + + H +R++G C L I
Sbjct: 3628 FTEGLRNEEATEGATAVLRCELS--KMAPVEWWKGHETLRDGDRH-SLRQDG-ARCELQI 3683
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
++D G Y M G+ S L V+++P +
Sbjct: 3684 RGLVAEDAGEYLCMC----GKERTSAMLTVRAMPSK------------------------ 3715
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
F++ + A EG L C++S P E W G L D L ++
Sbjct: 3716 --------FIEGLRNEEATEGDTATLWCELSKAAPVE--WR-KGHETLRDGDRHSLRQDG 3764
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
L I L DAG Y C+ GQ S L+V A + +E ++N EG
Sbjct: 3765 SRCELQIRGLAVVDAGEYSCVC----GQERTSATLTVRALPAR----FIEDVKNQEAREG 3816
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAKKSDAGWYT 1245
L+C + P W+K +ET+ +R S+ QD G C L I +D G Y+
Sbjct: 3817 ATAVLQCELSKAAP--VEWRKGSETLR-GGDRYSLRQD--GTRCELQIHGLSVADTGEYS 3871
Query: 1246 LSAKNEAGIVSCTAR 1260
E + T R
Sbjct: 3872 CVCGQERTSATLTVR 3886
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/180 (25%), Positives = 76/180 (42%), Gaps = 30/180 (16%)
Query: 221 DNEVNHALEQQEAKRREAEQAA---SEAAG-----------GDTTPGSSPSSLYYEEPLG 266
D ++ H LE R ++ Q A S A G G P P+S +E+ +
Sbjct: 5311 DKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLV- 5369
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL------ENSPDIHIVQA 320
PPR ++ ++V +G+ + V G P P V W E E ++P + +
Sbjct: 5370 -PPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
HSL + + + G Y+C ASN G SA +++ G+ P EE ++++
Sbjct: 5429 AQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGL--------PKVEEQEKVKE 5480
Score = 57.4 bits (137), Expect = 9e-08
Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 3/111 (2%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP + + G Q + I+ G P P V WY + +L +S + Q G +SL
Sbjct: 6355 RPPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSL 6414
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNR 377
+ +D G Y+C A N G AE+ + G D+E D K+ R
Sbjct: 6415 VLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLG---GDNEPDSEKQSHRR 6462
Score = 56.2 bits (134), Expect = 2e-07
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 428 GKPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
GK ++ P F ++ EG+ F C ++GAP P++ WY++G L+ F+ L
Sbjct: 6100 GKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTL-S 6158
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+PRS + LVI ED G + C N+ G+ + A+L ++
Sbjct: 6159 EPRS-----GLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQ 6200
Score = 55.5 bits (132), Expect = 3e-07
Identities = 72/323 (22%), Positives = 120/323 (37%), Gaps = 53/323 (16%)
Query: 939 TGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG 998
T + + F + +K+ EG+ C++ V W K G + + + +R++G
Sbjct: 3796 TVRALPARFIEDVKNQEAREGATAVLQCELS--KAAPVEWRK-GSETLRGGDRYSLRQDG 3852
Query: 999 DGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRV 1058
C L I + D G Y+ +
Sbjct: 3853 T-RCELQIHGLSVADTGEYSCVCG------------------------------------ 3875
Query: 1059 QERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAS 1118
QER L R +P F + + A EG L C++S P + W G + +
Sbjct: 3876 QERTSATLTVRAPQPVFREPLQSLQAEEGSTATLQCELSE-PTATVVWSKGGLQLQANGR 3934
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
+ ++ +L D L + D G Y C G + S L+V A V+ L +L
Sbjct: 3935 REPRLQGCTAELVLQD-LQREDTGEYTCTC----GSQATSATLTVTAAPVR----FLREL 3985
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q+ V EG L C + V + K + PC + + M QD A LL++ ++
Sbjct: 3986 QHQEVDEGGTAHLCCELSRAGASVEWRKGSLQLFPCAKYQ--MVQDGAA-AELLVRGVEQ 4042
Query: 1239 SDAGWYTLSAKNEAGIVSCTARL 1261
DAG YT + + S + R+
Sbjct: 4043 EDAGDYTCDTGHTQSMASLSVRV 4065
Score = 55.5 bits (132), Expect = 3e-07
Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 1/97 (1%)
Query: 264 PLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP-DIHIVQAGN 322
P+ +PP F ++L G V+L C V G P P + WY +GK ++ P I I
Sbjct: 6009 PVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG 6068
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE 359
+L + D+G+Y CFA++ G ST +I ++
Sbjct: 6069 SCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ 6105
Score = 54.7 bits (130), Expect = 6e-07
Identities = 82/323 (25%), Positives = 117/323 (36%), Gaps = 57/323 (17%)
Query: 939 TGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREG 998
T K + F + L++ EG+ C++ V V W K G + + + +R+EG
Sbjct: 3444 TVKALPAKFTEGLRNEEAVEGATAMLWCELS--KVAPVEWRK-GPENLRDGDRYILRQEG 3500
Query: 999 DGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRV 1058
C L I D G Y + G+ S L +++LP R
Sbjct: 3501 T-RCELQICGLAMADAGEYLCVC----GQERTSATLTIRALPAR---------------- 3539
Query: 1059 QERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAS 1118
F++ + A EG L C+++ P E W G L D
Sbjct: 3540 ----------------FIEDVKNQEAREGATAVLQCELNSAAPVE--W-RKGSETLRDGD 3580
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
L ++ L I L D G Y C+ GQ S L+V A +K E L
Sbjct: 3581 RYSLRQDGTKCELQIRGLAMADTGEYSCVC----GQERTSAMLTVRALPIK----FTEGL 3632
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAK 1237
+N EG L C + M P W K +ET+ +R S+ QD G C L I+
Sbjct: 3633 RNEEATEGATAVLRCELSKMAP--VEWWKGHETLR-DGDRHSLRQD--GARCELQIRGLV 3687
Query: 1238 KSDAGWYTLSAKNEAGIVSCTAR 1260
DAG Y E T R
Sbjct: 3688 AEDAGEYLCMCGKERTSAMLTVR 3710
Score = 53.5 bits (127), Expect = 1e-06
Identities = 73/304 (24%), Positives = 118/304 (38%), Gaps = 38/304 (12%)
Query: 249 DTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV-RWYCEGK 307
DT S +SL P P+F +L+S E G +L C + V +W EG
Sbjct: 4051 DTGHTQSMASLSVRVPR---PKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGV 4107
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI--------YIE 359
EL P + G L I + +DTG Y+C + G T+A + +
Sbjct: 4108 ELHAGPKYEMRSQGATRELLIHQLEAKDTGEYAC----VTGGQKTAASLRVTEPEVTIVR 4163
Query: 360 GVSSSDSEGDPNKEEMNRIQKPNEV-------SSPPTTSAVIPPAVPQAQHLVAQPRVAT 412
G+ ++ D + E + + P ++ V AV + + + T
Sbjct: 4164 GLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVT 4223
Query: 413 IQQCQSPTNYL--QGLDGKPIIAAPVFT--KMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ + + +L + + AP T + LQ++ SEGQ F+CR+ A + W
Sbjct: 4224 PEDAGTVSFHLGNHASSAQLTVRAPEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARW 4283
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIA 528
G ++ + I E + L + +V ED+G T S GT SS A
Sbjct: 4284 ALGGVPLQANEMNDI-------TVEQGTLHLLTLHKVTLEDAG----TVSFHVGTCSSEA 4332
Query: 529 QLHV 532
QL V
Sbjct: 4333 QLKV 4336
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/323 (23%), Positives = 120/323 (37%), Gaps = 54/323 (16%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
A F + L + +V E FTCK P V W K ++ +H + +EG T
Sbjct: 2915 ANCFTEELTNLQVEEKGTAVFTCKTEH-PAATVTWRKGLLELRASGKH-QPSQEGL-TLR 2971
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L I + D YT Q R L+VQ GR
Sbjct: 2972 LTISALEKADSDTYTCDIGQAQSR----AQLLVQ----------------GR-------- 3003
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
R H ++ D+ EG C++S + W L+ P+ + +++
Sbjct: 3004 --------RVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDA 3055
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGV 1183
+ G H L + L +D+GT A ++ S + +K V +L + +
Sbjct: 3056 QPGGYHVLTLRQLALKDSGTIYFEAGDQ--------RASAALRVTEKPSVFSRELTDATI 3107
Query: 1184 PEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
EG + L C PV W KD +T+ + H+ A LLI A D+G
Sbjct: 3108 TEGEDLTLVCETSTCDIPV-CWTKDGKTLRGSARCQLSHEGHR--AQLLITGATLQDSGR 3164
Query: 1244 YTLSAKNEAGIVSCTARLDIYAQ 1266
Y K EAG ++ + ++A+
Sbjct: 3165 Y----KCEAGGACSSSIVRVHAR 3183
Score = 52.4 bits (124), Expect = 3e-06
Identities = 78/347 (22%), Positives = 124/347 (35%), Gaps = 56/347 (16%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+F G + C + + W KDG +++ H + + GDGTCSL
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHH-HIDQLGDGTCSL 4956
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I D G YT +N G+++ S ++V + +S G+ R R
Sbjct: 4957 LITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDAFRRAARR--- 5013
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
R FR ++P + + EL + P P+
Sbjct: 5014 --LHRLFR---TKSPAE-----------------VSDEELFLSADEGPAEPEEPADWQTY 5051
Query: 1125 ETGVHSLLI--DPLTQ-RDAGT--YKCIATNKTG-------QNSFSLELSVVAKEVKKAP 1172
H + I + LT+ R A T + AT G Q +E+ ++KE
Sbjct: 5052 REDEHFICIRFEALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEM-CISKETPAPV 5110
Query: 1173 VILEKLQNCGVPEGHPVRL----------------ECRVIGMPPPVFYWKKDNETIPCTR 1216
V E L + + PV L +C V G P P W KD + +
Sbjct: 5111 VPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLE-ED 5169
Query: 1217 ERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
+ +++D G L+I +D G Y A+N G+ S A L +
Sbjct: 5170 DHYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRV 5216
Score = 52.0 bits (123), Expect = 4e-06
Identities = 33/110 (30%), Positives = 50/110 (45%), Gaps = 7/110 (6%)
Query: 1164 VAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQ 1223
+A V + P E+L +C G V+L CRV G P PV W KD + + I + +
Sbjct: 6006 LALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHI-LIE 6064
Query: 1224 DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
D G L++ D+G Y A + AG S ++ + Q+PP
Sbjct: 6065 DPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILV------QVPP 6108
Score = 51.2 bits (121), Expect = 6e-06
Identities = 72/283 (25%), Positives = 109/283 (38%), Gaps = 56/283 (19%)
Query: 972 PVPK-VYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISC 1030
P PK V W+KD +S +E KM EG L I D G Y A
Sbjct: 2494 PAPKAVQWYKDDTPLSP-SEKFKMSLEGQ-MAELRILRLMPADAGVYRCQAG-------- 2543
Query: 1031 SGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLC 1090
S H + +T G PLQ D A E
Sbjct: 2544 SAHSSTEVTVEAREVTVTG---------------PLQ-------------DAEATEEGWA 2575
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
C++S E+ W LNG P+ D+ H+ + + H+L++ + + DAG +
Sbjct: 2576 SFSCELSH-EDEEVEWSLNGMPLYNDSFHE-ISHKGRRHTLVLKSIQRADAGIVR----- 2628
Query: 1151 KTGQNSFSLELSVVAK-EVKKAPVI-LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKD 1208
+ SL++S A+ EV+ PV+ L+ L + E + L+C V P W+KD
Sbjct: 2629 -----ASSLKVSTSARLEVRVKPVVFLKALDDLSAEERGTLALQCEV-SDPEAHVVWRKD 2682
Query: 1209 NETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
+ + + +H T G L++ DAG YT +E
Sbjct: 2683 GVQLGPSDKYDFLH--TAGTRGLVVHDVSPEDAGLYTCHVGSE 2723
Score = 51.2 bits (121), Expect = 6e-06
Identities = 34/118 (28%), Positives = 53/118 (44%), Gaps = 14/118 (11%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
P ++++ A G FE ++G P P V WY++ + DS S +
Sbjct: 6357 PSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRL--------SQQQE 6408
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG------NEDLSNNGSLHS 546
+LV+ V ++D+G +TC A N G V A+L V G +E S+ LHS
Sbjct: 6409 GTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGDNEPDSEKQSHRRKLHS 6466
Score = 50.4 bits (119), Expect = 1e-05
Identities = 74/303 (24%), Positives = 110/303 (36%), Gaps = 66/303 (21%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+F + L+ + EGS T C++ P V W K G Q+ + N + R +G T L
Sbjct: 3890 PVFREPLQSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQL-QANGRREPRLQGC-TAEL 3946
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
++ +D G YT G + S L V + P+R
Sbjct: 3947 VLQDLQREDTGEYTCTC----GSQATSATLTVTAAPVR---------------------- 3980
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
FL+ EG L C++S + W + P A ++M V+
Sbjct: 3981 ----------FLRELQHQEVDEGGTAHLCCELSRAGA-SVEWRKGSLQLFPCAKYQM-VQ 4028
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
+ LL+ + Q DAG Y C TG LSV P +LQ+
Sbjct: 4029 DGAAAELLVRGVEQEDAGDYTC----DTGHTQSMASLSVRVPR----PKFKTRLQSLEQE 4080
Query: 1185 EGHPVRLECRVIGMPP-PVFYWKKDNETI-----------PCTRERISMHQ----DTTGY 1228
G RL C++ V W K+ + TRE + +HQ DT Y
Sbjct: 4081 TGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRE-LLIHQLEAKDTGEY 4139
Query: 1229 ACL 1231
AC+
Sbjct: 4140 ACV 4142
Score = 50.4 bits (119), Expect = 1e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 7/97 (7%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP F + L + + GQ V C+V P+ + W ++G +E S R+L A
Sbjct: 7462 APTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSS--RVL-----ISAT 7514
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
+ L I V AED G +TC+ SN GTV++ L
Sbjct: 7515 LKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVL 7551
Score = 49.7 bits (117), Expect = 2e-05
Identities = 73/307 (23%), Positives = 120/307 (39%), Gaps = 51/307 (16%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIV-QAGNLHSL 326
P +F + LR+ E EG L C + P + R +G E D H + Q G+ L
Sbjct: 3713 PSKFIEGLRNEEATEGDTATLWCELSKAAPVEWR---KGHETLRDGDRHSLRQDGSRCEL 3769
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I D G YSC + G + TSA + + + + E N+E + V
Sbjct: 3770 QIRGLAVVDAGEYSC----VCGQERTSATLTVRALPARFIEDVKNQEAR---EGATAVLQ 3822
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQ---QCQSPTNYLQGLD--------GKPIIAA- 434
+ A ++ L R + Q +C+ + L D G+ +A
Sbjct: 3823 CELSKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVCGQERTSAT 3882
Query: 435 -------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
PVF + LQ+L A EG +C + P+ V W + G LQ +
Sbjct: 3883 LTVRAPQPVFREPLQSLQAEEGSTATLQCEL-SEPTATVVWSKGG-----------LQLQ 3930
Query: 488 PRSMAEPE-EICT--LVIAEVFAEDSGCFTCTASNKYG------TVSSIAQLHVRGNEDL 538
EP + CT LV+ ++ ED+G +TCT ++ T + + L ++++
Sbjct: 3931 ANGRREPRLQGCTAELVLQDLQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEV 3990
Query: 539 SNNGSLH 545
G+ H
Sbjct: 3991 DEGGTAH 3997
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/381 (23%), Positives = 140/381 (36%), Gaps = 81/381 (21%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P F++ L+ E +V L+C + P VRW +G EL + I G SLT
Sbjct: 2165 PVSFSRPLQDVVTTEKEKVTLEC-ELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLT 2223
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I D G Y C A + +SA + ++G + + E+ IQ
Sbjct: 2224 IYRCEFADQGVYVCDAHDA----QSSASVKVQGRTYTLIYRRVLAEDAGEIQ-------- 2271
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSAS 447
V A +AQ V + V + + L++ A
Sbjct: 2272 ----FVAENAESRAQLRVKELPVTLV-------------------------RPLRDKIAM 2302
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
E V EC+V A S +V W++ ++ P + ++ L+I++V A
Sbjct: 2303 EKHRGVLECQVSRA-SAQVRWFKGSQELQPGPKYELVSDGLYR--------KLIISDVHA 2353
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEP 567
ED +TC A G V + AQ V S+ ++ +EP P+ E
Sbjct: 2354 EDEDTYTCDA----GDVKTSAQFFV-------EEQSITIVRGLQDVTVMEPAPAWFECET 2402
Query: 568 --PSVEQPPKPKL---------------EGVLVNHNEPRSSSRIGLRVHFNLPEDDKGSE 610
PSV +PPK L EG + R+ S + VHF + + +
Sbjct: 2403 SIPSV-RPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSAR 2461
Query: 611 -ASSEAGVVTTRQTRPDSFQE 630
S+ VV TR P + +E
Sbjct: 2462 LVVSDIPVVLTRPLEPKTGRE 2482
Score = 48.9 bits (115), Expect = 3e-05
Identities = 85/400 (21%), Positives = 143/400 (35%), Gaps = 76/400 (19%)
Query: 158 IEELSSLFKSHSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPA 217
I E +F S +A + L + Q + + D + S V + +
Sbjct: 1067 ITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTEVTWYKDGKKLSSSSKVGMEVKG 1126
Query: 218 DTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRS 277
TR L +A + +A + + EA G + L+ EP G +
Sbjct: 1127 CTR------RLVLPQAGKADAGEYSCEAGGQRVS-----FHLHITEPKGVFAKEQSVHNE 1175
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
+ GT L C V P +V WY +GK+L +S + + G L + + + D G
Sbjct: 1176 VQAEAGTTAMLSCEVAQ-PQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAG 1234
Query: 338 RYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPA 397
YSC A G S +++I ++ + KE++ NEV + SA +
Sbjct: 1235 EYSCEA----GGQRVSFQLHI-----TEPKAVFAKEQLVH----NEVRTEAGASATLSCE 1281
Query: 398 VPQAQHLVAQ--------------------PRVATIQQC--------------QSPTNYL 423
V QAQ V R +QQ Q + +L
Sbjct: 1282 VAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHL 1341
Query: 424 QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
+ K + A + + A G + C V A + +V WY++G + S R+
Sbjct: 1342 DVSEPKAVFAKEQLAH--RKVQAEAGAIATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRM 1398
Query: 484 LQKKPRSMAEPEEI-CT--LVIAEVFAEDSGCFTCTASNK 520
E + CT LV+ + D+G ++C A +
Sbjct: 1399 -----------EAVGCTRRLVVQQACQADTGEYSCEAGGQ 1427
Score = 48.9 bits (115), Expect = 3e-05
Identities = 78/315 (24%), Positives = 115/315 (36%), Gaps = 57/315 (18%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F +L++ TEG+ T C++ V W K + + + +C +R++G C L I
Sbjct: 3276 FIGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLRDGDRYC-LRQDG-AMCELQI 3331
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
D Y+ + G S L ++ +P GR R QE
Sbjct: 3332 RGLAMVDAAEYSCVC----GEERTSASLTIRPMPAH---------FIGRLRHQE------ 3372
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
+ EG L C++S P E W G+ L D L ++
Sbjct: 3373 -----------------SIEGATATLRCELSKAAPVE--WR-KGRESLRDGDRHSLRQDG 3412
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
V L I L DAG Y C+ G+ S L+V A K E L+N EG
Sbjct: 3413 AVCELQICGLAVADAGEYSCVC----GEERTSATLTVKALPAK----FTEGLRNEEAVEG 3464
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAKKSDAGWYT 1245
L C + + P W+K E + +R + Q+ G C L I +DAG Y
Sbjct: 3465 ATAMLWCELSKVAP--VEWRKGPENLR-DGDRYILRQE--GTRCELQICGLAMADAGEYL 3519
Query: 1246 LSAKNEAGIVSCTAR 1260
E + T R
Sbjct: 3520 CVCGQERTSATLTIR 3534
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/102 (31%), Positives = 52/102 (50%), Gaps = 8/102 (7%)
Query: 1094 CKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTG 1153
C+VS + W L G P+ + ++ VR+ +H+L + +T DAGT + G
Sbjct: 4180 CEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAGT----VSFHLG 4235
Query: 1154 QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
++ S +L+V A EV ILE LQ+ + EG +CR+
Sbjct: 4236 NHASSAQLTVRAPEV----TILEPLQDVQLSEGQDASFQCRL 4273
Score = 48.5 bits (114), Expect = 4e-05
Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 5/122 (4%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLR--SREVPE--G 283
+E RR Q A +A G+ + + L + + +P K + SREV G
Sbjct: 1490 MEAVGCTRRLVVQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAG 1549
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
T L C V +V WY +GK+L +S + + G L + EA + D G YSC A
Sbjct: 1550 TSATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKA 1608
Query: 344 SN 345
+
Sbjct: 1609 GD 1610
Score = 48.5 bits (114), Expect = 4e-05
Identities = 44/142 (30%), Positives = 60/142 (42%), Gaps = 4/142 (2%)
Query: 252 PGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELEN 311
PG + L + + P F ++L V G V L C V P Q W +G LE+
Sbjct: 7446 PGLASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLES 7505
Query: 312 SPDIHI-VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI-YIEGVSSSDSE-- 367
S + I N LTI ED G Y+C SN GT +T+ + E SSS
Sbjct: 7506 SSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDI 7565
Query: 368 GDPNKEEMNRIQKPNEVSSPPT 389
G+ + + + KP E P T
Sbjct: 7566 GEVYADGVLLVWKPVESYGPVT 7587
Score = 48.1 bits (113), Expect = 5e-05
Identities = 55/257 (21%), Positives = 90/257 (35%), Gaps = 46/257 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
VT V F+C++ V W G + NE ++ +L ++ T +D G
Sbjct: 4170 VTADEDVEFSCEVSRAGATGVQWCLQGLPLQS-NEVTEVAVRDGRIHTLRLKGVTPEDAG 4228
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+ N H L +R+ + EPLQ
Sbjct: 4229 TVSFHLGN---------HASSAQLTVRAPEVTI--------------LEPLQ-------- 4257
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
D+ EG+ C++S E W L G P+ + + + V + +H L +
Sbjct: 4258 -----DVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHK 4312
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
+T DAGT + G S +L V AK ++ L+N EG EC++
Sbjct: 4313 VTLEDAGT----VSFHVGTCSSEAQLKVTAKN-----TVVRGLENVEALEGGEALFECQL 4363
Query: 1196 IGMPPPVFYWKKDNETI 1212
W D+E +
Sbjct: 4364 SQPEVAAHTWLLDDEPV 4380
Score = 47.8 bits (112), Expect = 7e-05
Identities = 67/268 (25%), Positives = 101/268 (37%), Gaps = 40/268 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +FT+ LR+ E EG L C + + P V W + L + + Q G L
Sbjct: 3449 PAKFTEGLRNEEAVEGATAMLWCELSKVAP--VEWRKGPENLRDGDRYILRQEGTRCELQ 3506
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I D G Y C + G + TSA + I + + E N+E + V
Sbjct: 3507 ICGLAMADAGEYLC----VCGQERTSATLTIRALPARFIEDVKNQEAR---EGATAVLQC 3559
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL----DGK-------------- 429
SA ++ L R + Q ++GL G+
Sbjct: 3560 ELNSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTSAML 3619
Query: 430 PIIAAPV-FTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTLIEDSPDFRILQKK 487
+ A P+ FT+ L+N A+EG V C + K AP VEW++ + D + Q
Sbjct: 3620 TVRALPIKFTEGLRNEEATEGATAVLRCELSKMAP---VEWWKGHETLRDGDRHSLRQDG 3676
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTC 515
R C L I + AED+G + C
Sbjct: 3677 AR--------CELQIRGLVAEDAGEYLC 3696
Score = 47.8 bits (112), Expect = 7e-05
Identities = 35/121 (28%), Positives = 53/121 (43%), Gaps = 6/121 (4%)
Query: 934 HDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCK 993
+ I T P ++ + G F I G P P V W+KD Q+ + +
Sbjct: 6346 YQAIDTHTARPPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLV---DSTR 6402
Query: 994 MRREGDGTC-SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSH 1052
+ ++ +GT SL + S D G YT +A N G++ C L+V L + S QSH
Sbjct: 6403 LSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV--LGGDNEPDSEKQSH 6460
Query: 1053 R 1053
R
Sbjct: 6461 R 6461
Score = 47.4 bits (111), Expect = 9e-05
Identities = 67/289 (23%), Positives = 114/289 (39%), Gaps = 49/289 (16%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG-TCSLHIESTTSDDDGNY 1017
G+ T +C++ +V W+KDGK++S + K+R E G T L ++ D G Y
Sbjct: 1549 GTSATLSCEVAQAQT-EVTWYKDGKKLSSSS---KVRMEAVGCTRRLVVQEAGQADAGEY 1604
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
+ A + + S HL H +V ++P
Sbjct: 1605 SCKAGDQR----LSFHL-----------------HVAEPKVVFAKEQP------------ 1631
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG-VHSLLIDPL 1136
A ++ A G L C+V+ E+TW +G+ + +S K+ V G L++
Sbjct: 1632 AHREVQAEAGASATLSCEVA-QAQTEVTWYKDGKKL--SSSSKVRVEAVGCTRRLVVQQA 1688
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
Q DAG Y C A + + SF L ++ + ++ + P E L V E + L +
Sbjct: 1689 GQADAGEYSCEAGGQ--RLSFRLHVAELEPQISERPCRREPLV---VKEHEDIILTATLA 1743
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
W KD I ++ + Q T L + A+ D+ Y+
Sbjct: 1744 TPSAATVTWLKDGVEIRRSKRHETASQGDT--HTLTVHGAQVLDSAIYS 1790
Score = 47.4 bits (111), Expect = 9e-05
Identities = 68/304 (22%), Positives = 117/304 (38%), Gaps = 43/304 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P RF + ++++E EG L C + P V W + L + + Q G L
Sbjct: 3537 PARFIEDVKNQEAREGATAVLQCELNSAAP--VEWRKGSETLRDGDRYSLRQDGTKCELQ 3594
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-----------EMN 376
I DTG YSC + G + TSA + + + +EG N+E E++
Sbjct: 3595 IRGLAMADTGEYSC----VCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCELS 3650
Query: 377 RIQ-----KPNEVSSPPTTSAVIPPAVP---QAQHLVAQPRVATIQQC-QSPTNYLQGLD 427
++ K +E ++ Q + LVA+ + C + T+ + +
Sbjct: 3651 KMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKERTSAMLTVR 3710
Query: 428 GKPIIAAPVFTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTLIEDSPDFRILQK 486
P F + L+N A+EG C + K AP VEW + + D + Q
Sbjct: 3711 AMP----SKFIEGLRNEEATEGDTATLWCELSKAAP---VEWRKGHETLRDGDRHSLRQD 3763
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS-SIAQLHVRGNEDLSNNGSLH 545
R C L I + D+G ++C + + + ++ L R ED+ N +
Sbjct: 3764 GSR--------CELQIRGLAVVDAGEYSCVCGQERTSATLTVRALPARFIEDVKNQEARE 3815
Query: 546 SANS 549
A +
Sbjct: 3816 GATA 3819
Score = 47.0 bits (110), Expect = 1e-04
Identities = 75/310 (24%), Positives = 117/310 (37%), Gaps = 72/310 (23%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC-SLHIESTTSDD 1013
R G+ T +C++ +V W+KDGK++S + K+R E G L ++ D
Sbjct: 1269 RTEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSS---KVRIEAAGCMRQLVVQQAGQAD 1324
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G YT A G S HL V + A KE L R
Sbjct: 1325 AGEYTCEA----GGQRLSFHLDVS----EPKAVFA--------------KEQLAHR---- 1358
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG-VHSLL 1132
+ A G + L C+V+ E+TW +G+ + +S K+ + G L+
Sbjct: 1359 -------KVQAEAGAIATLSCEVA-QAQTEVTWYKDGKKL--SSSSKVRMEAVGCTRRLV 1408
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ Q D G Y C A + + SFSL+++ K + ++Q G L
Sbjct: 1409 VQQACQADTGEYSCEAGGQ--RLSFSLDVAEPKVVFAKEQPVHREVQ---AQAGASTTLS 1463
Query: 1193 CRVIGMPPPVFYWKKDN-----------ETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
C V V W KD E + CTR L++Q A ++ A
Sbjct: 1464 CEVAQAQTEVM-WYKDGKKLSFSSKVRMEAVGCTRR-------------LVVQQAGQAVA 1509
Query: 1242 GWYTLSAKNE 1251
G Y+ A ++
Sbjct: 1510 GEYSCEAGSQ 1519
Score = 46.6 bits (109), Expect = 2e-04
Identities = 67/321 (20%), Positives = 120/321 (37%), Gaps = 43/321 (13%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKL----RSREVPEG 283
+E RR Q A +A G+ + + L + + +P K R + G
Sbjct: 1582 MEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAG 1641
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
L C V +V WY +GK+L +S + + G L + +A + D G YSC A
Sbjct: 1642 ASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Query: 344 SNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE----VSSPPTTSAVIPPAVP 399
G S +++ + SE +E + + K +E ++ T SA +
Sbjct: 1701 ----GGQRLSFRLHVAELEPQISERPCRREPL--VVKEHEDIILTATLATPSAATVTWLK 1754
Query: 400 QAQHLVAQPRVATIQQCQSPTNYLQG---LDGK-------------PIIAAPV---FTKM 440
+ R T Q + T + G LD P+ V F ++
Sbjct: 1755 DGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDFPVQVEEVAAKFCRL 1814
Query: 441 LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTL 500
L+ + G V C + A +V W T + F+++ + P + +L
Sbjct: 1815 LEPVCGELGGTVTLACELSPA-CAEVVWRCGNTQLRVGKRFQMVAEGP--------VRSL 1865
Query: 501 VIAEVFAEDSGCFTCTASNKY 521
+ + AED+G + C + + +
Sbjct: 1866 TVLGLRAEDAGEYVCESRDDH 1886
Score = 46.6 bits (109), Expect = 2e-04
Identities = 76/335 (22%), Positives = 129/335 (38%), Gaps = 67/335 (20%)
Query: 235 RREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQ-PPRFTQKLRSRE---VPEGTRVQLDC 290
RR Q A +A G+ + + L + + + P+ +++ RE V E + L
Sbjct: 1681 RRLVVQQAGQADAGEYSCEAGGQRLSFRLHVAELEPQISERPCRREPLVVKEHEDIILTA 1740
Query: 291 IVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 350
+ V W +G E+ S G+ H+LT+ A D+ YSC G +
Sbjct: 1741 TLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRV----GAE 1796
Query: 351 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKP--NEVSSPPTTSAVIPPA----------- 397
+ +E V++ + R+ +P E+ T + + PA
Sbjct: 1797 GQDFPVQVEEVAA----------KFCRLLEPVCGELGGTVTLACELSPACAEVVWRCGNT 1846
Query: 398 ---VPQAQHLVAQPRVATIQQ------------CQSPTNYLQGLDGKPIIAAPVFTKMLQ 442
V + +VA+ V ++ C+S ++ + ++ P K +
Sbjct: 1847 QLRVGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSA---QLTVSVPRVVKFMS 1903
Query: 443 NLS---ASEGQLVVFECRVKGAPSP-KVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
LS A EG F+C V +PS V W+R+G L++ S F I Q
Sbjct: 1904 GLSTVVAEEGGEATFQCVV--SPSDVAVVWFRDGALLQPSEKFAISQSGASH-------- 1953
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+L I+++ ED+G T A SS A L VR
Sbjct: 1954 SLTISDLVLEDAGQITVEAEG----ASSSAALRVR 1984
Score = 46.2 bits (108), Expect = 2e-04
Identities = 74/331 (22%), Positives = 119/331 (35%), Gaps = 63/331 (19%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSR----EVPEG 283
+E RR Q A +A G+ + + L + + +P K + + G
Sbjct: 938 MEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAG 997
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
L C V +V WY +GK+L +S +H+ G L + +A + D G YSC A
Sbjct: 998 ASATLSCEVAQAQT-EVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA 1056
Query: 344 SNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQ- 402
S ++I +P NEV + SA++ V QAQ
Sbjct: 1057 RG----QRVSFRLHIT---------EPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQT 1103
Query: 403 ---------HLVAQPRVA-TIQQC-----------QSPTNYLQGLDGKPI-----IAAP- 435
L + +V ++ C Y G+ + I P
Sbjct: 1104 EVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPK 1163
Query: 436 -VFTK---MLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
VF K + + A G + C V P +V WY++G + S R+ K
Sbjct: 1164 GVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKG---- 1218
Query: 492 AEPEEICT--LVIAEVFAEDSGCFTCTASNK 520
CT LV+ +V D+G ++C A +
Sbjct: 1219 ------CTRRLVVQQVGKADAGEYSCEAGGQ 1243
Score = 45.8 bits (107), Expect = 3e-04
Identities = 68/292 (23%), Positives = 112/292 (38%), Gaps = 50/292 (17%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG-TCSLHIESTTSDDDGNY 1017
G+ +C++ P +V W+KDGK++S + K+R E G T L ++ D G Y
Sbjct: 1181 GTTAMLSCEVAQ-PQTEVTWYKDGKKLSSSS---KVRMEVKGCTRRLVVQQVGKADAGEY 1236
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
+ A R+S H+ KE L R
Sbjct: 1237 SCEAGGQ--RVSFQLHITEPKAVFA--------------------KEQLVHNEVR----- 1269
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG-VHSLLIDPL 1136
G L C+V+ E+TW +G+ + +S K+ + G + L++
Sbjct: 1270 ------TEAGASATLSCEVA-QAQTEVTWYKDGKKL--SSSSKVRIEAAGCMRQLVVQQA 1320
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
Q DAG Y C A + + SF L++S K + K+Q G L C V
Sbjct: 1321 GQADAGEYTCEAGGQ--RLSFHLDVSEPKAVFAKEQLAHRKVQ---AEAGAIATLSCEVA 1375
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
V ++K + ++ R+ T L++Q A ++D G Y+ A
Sbjct: 1376 QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR---LVVQQACQADTGEYSCEA 1424
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/107 (28%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P RF + L+ EV EG L C++ + P V+W L + Q G + L
Sbjct: 3183 RPVRFQEALKDLEVLEGGAATLRCVLSSVAAP-VKWCYGNNVLRPGDKYSLRQEGAMLEL 3241
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
+ +D+GRYSC +G +TSA + + + + NKE
Sbjct: 3242 VVRNLRPQDSGRYSC----SFGDQTTSATLTVTALPAQFIGKLRNKE 3284
Score = 44.7 bits (104), Expect = 6e-04
Identities = 91/388 (23%), Positives = 141/388 (36%), Gaps = 63/388 (16%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIH-IVQAGNLHSL 326
P +FT+ LR+ E EG L C + + P V W+ +G E D H + Q G L
Sbjct: 3625 PIKFTEGLRNEEATEGATAVLRCELSKMAP--VEWW-KGHETLRDGDRHSLRQDGARCEL 3681
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
I ED G Y C G + TSA + + + S EG N+E + + +
Sbjct: 3682 QIRGLVAEDAGEYLCMC----GKERTSAMLTVRAMPSKFIEGLRNEE----ATEGDTATL 3733
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQ----CQSPTNYLQGLD--------GKPIIAA 434
S P + + +++Q C+ L +D G+ +A
Sbjct: 3734 WCELSKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSA 3793
Query: 435 PV--------FTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTLIEDSPDFRILQ 485
+ F + ++N A EG V +C + K AP VEW + + + + Q
Sbjct: 3794 TLTVRALPARFIEDVKNQEAREGATAVLQCELSKAAP---VEWRKGSETLRGGDRYSLRQ 3850
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNN--GS 543
R C L I + D+G ++C G + A L VR + + S
Sbjct: 3851 DGTR--------CELQIHGLSVADTGEYSCVC----GQERTSATLTVRAPQPVFREPLQS 3898
Query: 544 LHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLP 603
L + +T E SEP + K L+ EPR V +L
Sbjct: 3899 LQAEEGSTATLQCE------LSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQ 3952
Query: 604 EDDK-------GSEASSEAGVVTTRQTR 624
+D GS+A+S VT R
Sbjct: 3953 REDTGEYTCTCGSQATSATLTVTAAPVR 3980
Score = 43.5 bits (101), Expect = 0.001
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 18/172 (10%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
++ A G L C+V+ P E+TW +G+ + + +M V+ L++ + + D
Sbjct: 1175 EVQAEAGTTAMLSCEVAQ-PQTEVTWYKDGKKLSSSSKVRMEVKGC-TRRLVVQQVGKAD 1232
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP 1200
AG Y C A + + SF L ++ K ++ +++ G L C V
Sbjct: 1233 AGEYSCEAGGQ--RVSFQLHITEPKAVFAKEQLVHNEVRT---EAGASATLSCEVAQAQT 1287
Query: 1201 PVFYWKKDNETIPCTRERIS----MHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
V ++K + ++ RI M Q L++Q A ++DAG YT A
Sbjct: 1288 EVTWYKDGKKLSSSSKVRIEAAGCMRQ-------LVVQQAGQADAGEYTCEA 1332
Score = 43.5 bits (101), Expect = 0.001
Identities = 54/241 (22%), Positives = 88/241 (36%), Gaps = 40/241 (16%)
Query: 297 PPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS--- 353
P V+WY + L S + G + L I D G Y C A + + + +
Sbjct: 2496 PKAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTEVTVEA 2555
Query: 354 -----------AEIYIEGVSSSDSEGDPNKEE----MNRIQKPN----EVSSPPTTSAVI 394
AE EG +S E EE +N + N E+S ++
Sbjct: 2556 REVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLYNDSFHEISHKGRRHTLV 2615
Query: 395 PPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
++ +A + + + T+ + KP+ VF K L +LSA E +
Sbjct: 2616 LKSIQRADAGIVRASSLKVS-----TSARLEVRVKPV----VFLKALDDLSAEERGTLAL 2666
Query: 455 ECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFT 514
+C V P V W ++G + S + L LV+ +V ED+G +T
Sbjct: 2667 QCEVSD-PEAHVVWRKDGVQLGPSDKYDFLHTAGTR--------GLVVHDVSPEDAGLYT 2717
Query: 515 C 515
C
Sbjct: 2718 C 2718
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/113 (26%), Positives = 46/113 (40%), Gaps = 26/113 (23%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQ---------------ISK 987
+ P +R +V +GS +TF+ K+ G PVP V+W ++ + S
Sbjct: 5369 VPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASS 5428
Query: 988 RNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+H SL + G YT +A+N G+ CS L V LP
Sbjct: 5429 AQQH-----------SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLP 5470
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 1081 DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD 1140
D+ A G + + + G P P +TW + ++ D++ +E +SL++ + +D
Sbjct: 6365 DVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLV-DSTRLSQQQEGTTYSLVLRHVASKD 6423
Query: 1141 AGTYKCIATNKTGQNSFSLELSVV 1164
AG Y C+A N GQ EL V+
Sbjct: 6424 AGVYTCLAQNTGGQVLCKAELLVL 6447
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 16/129 (12%)
Query: 243 SEAAGGDTTPGSSPSSLYY-----------EEPLGQPPRFTQKLRSREVPEGTRVQLDCI 291
S+AA + PG+S ++L E PP + R+ V EG +L C
Sbjct: 203 SDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP--STGTRTCTVTEGKHARLSCY 260
Query: 292 VVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAF--EEDTGRYSCFASNIYGT 349
V G P P+ W +G +L H+V + + F + D G Y+C ASN+ G
Sbjct: 261 VTGEPKPETVWKKDG-QLVTEGRRHVVYEDAQENFVLKILFCKQSDRGLYTCTASNLVGQ 319
Query: 350 DSTSAEIYI 358
+S + +
Sbjct: 320 TYSSVLVVV 328
Score = 40.8 bits (94), Expect = 0.009
Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 8/107 (7%)
Query: 426 LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQ 485
+D AP F + S G+ C++ G P+P+V W ++ + FR
Sbjct: 1 MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFR--- 57
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+A+ ++ L I ++ DSG + C A N G + L V
Sbjct: 58 -----LAQDGDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQV 99
Score = 40.8 bits (94), Expect = 0.009
Identities = 72/323 (22%), Positives = 117/323 (36%), Gaps = 47/323 (14%)
Query: 228 LEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKL----RSREVPEG 283
+E RR Q A +A G+ + + L + + +P K R + G
Sbjct: 1398 MEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAG 1457
Query: 284 TRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
L C V +V WY +GK+L S + + G L + +A + G YSC A
Sbjct: 1458 ASTTLSCEVAQAQT-EVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCEA 1516
Query: 344 SNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNR------------IQKPNEVS------ 385
G+ S +++ + ++ P E+ Q EV+
Sbjct: 1517 ----GSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVAQAQTEVTWYKDGK 1572
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAP--VFTK---M 440
++S V AV + LV Q S Q L +A P VF K
Sbjct: 1573 KLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPA 1632
Query: 441 LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEI-CT 499
+ + A G C V A + +V WY++G + S R+ E + CT
Sbjct: 1633 HREVQAEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRV-----------EAVGCT 1680
Query: 500 --LVIAEVFAEDSGCFTCTASNK 520
LV+ + D+G ++C A +
Sbjct: 1681 RRLVVQQAGQADAGEYSCEAGGQ 1703
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/111 (29%), Positives = 43/111 (38%), Gaps = 4/111 (3%)
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNE 1210
K G SF L K +AP L +L + V G V L C+V P W KD
Sbjct: 7445 KPGLASFRLS---GLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGA 7501
Query: 1211 TIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ + R+ + + L I D G YT S N G V+ T L
Sbjct: 7502 PLE-SSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVL 7551
Score = 40.4 bits (93), Expect = 0.011
Identities = 69/310 (22%), Positives = 118/310 (38%), Gaps = 58/310 (18%)
Query: 949 KRLKHFRVTE--GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDG-TCSLH 1005
++L H +V G+ T +C++ +V W+KDGK++S + K+R E G T L
Sbjct: 1353 EQLAHRKVQAEAGAIATLSCEVAQAQT-EVTWYKDGKKLSSSS---KVRMEAVGCTRRLV 1408
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
++ D G Y+ A G + SL + +V ++P
Sbjct: 1409 VQQACQADTGEYSCEA---------GGQRLSFSLDV------------AEPKVVFAKEQP 1447
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
+ ++ A G L C+V+ E+ W +G+ + S K+ +
Sbjct: 1448 VHR------------EVQAQAGASTTLSCEVA-QAQTEVMWYKDGKKL--SFSSKVRMEA 1492
Query: 1126 TG-VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV---AKEVKKAPVILEKLQNC 1181
G L++ Q AG Y C + G S L V A K+ P E
Sbjct: 1493 VGCTRRLVVQQAGQAVAGEYSC----EAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEA 1548
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
G L C V V ++K + ++ R+ T L++Q A ++DA
Sbjct: 1549 GT----SATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR---LVVQEAGQADA 1601
Query: 1242 GWYTLSAKNE 1251
G Y+ A ++
Sbjct: 1602 GEYSCKAGDQ 1611
Score = 39.7 bits (91), Expect = 0.019
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 8/114 (7%)
Query: 1171 APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC 1230
AP L + + V G L C+++G P P W+KD + + R + QD Y
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV-AAGARFRLAQDGDLYRL 67
Query: 1231 LLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYA------QWHHQIPPPMSVR 1278
++ A D+G Y A+N G L + A Q H + P S+R
Sbjct: 68 TILDLA-LGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIR 120
Score = 38.9 bits (89), Expect = 0.033
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 9/90 (10%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
S P ++ +E L + R + G L C V +V WY +GK+L +S
Sbjct: 884 SEPKVVFAKEQLAR--------RKLQAEAGASATLSCEVAQAQT-EVTWYKDGKKLSSSS 934
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFA 343
+ + G L + +A + D G YSC A
Sbjct: 935 KVCMEATGCTRRLVVQQAGQADAGEYSCEA 964
Score = 38.9 bits (89), Expect = 0.033
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 4/83 (4%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET--GVHS 1130
P FL+ D G+ L C+VS P + TW +G P+ ++S ++L+ T
Sbjct: 7463 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPL--ESSSRVLISATLKNFQL 7520
Query: 1131 LLIDPLTQRDAGTYKCIATNKTG 1153
L I + D G Y C +N G
Sbjct: 7521 LTILVVVAEDLGVYTCSVSNALG 7543
Score = 38.5 bits (88), Expect = 0.043
Identities = 63/297 (21%), Positives = 102/297 (34%), Gaps = 53/297 (17%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P RF ++L+ +EV EG L C + V W +L +VQ G L
Sbjct: 3978 PVRFLRELQHQEVDEGGTAHL-CCELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELL 4036
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS- 386
+ +ED G Y+C + S S + P + R+Q + +
Sbjct: 4037 VRGVEQEDAGDYTCDTGHTQSMASLSVRV-------------PRPKFKTRLQSLEQETGD 4083
Query: 387 --------PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPI------- 431
S + + + L A P+ Q + + L+ K
Sbjct: 4084 IARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYACVT 4143
Query: 432 ----------IAAPVFT--KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ P T + L + + + V F C V A + V+W +G ++ +
Sbjct: 4144 GGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQSNE 4203
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNE 536
+ + R I TL + V ED+G T S G +S AQL VR E
Sbjct: 4204 VTEVAVRDGR-------IHTLRLKGVTPEDAG----TVSFHLGNHASSAQLTVRAPE 4249
Score = 38.1 bits (87), Expect = 0.056
Identities = 40/147 (27%), Positives = 64/147 (43%), Gaps = 16/147 (10%)
Query: 1106 WLLNGQPVLPDASHKMLVRETGV-HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
W +G L + + L + G H L+ +T++D GTY C + G++S L V
Sbjct: 830 WYKDGME-LGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSC----RVGEDSVDFRLRVS 884
Query: 1165 AKEV--KKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+V K + KLQ G L C V V W KD + + + + +
Sbjct: 885 EPKVVFAKEQLARRKLQ---AEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSK---VC 937
Query: 1223 QDTTGYA-CLLIQPAKKSDAGWYTLSA 1248
+ TG L++Q A ++DAG Y+ A
Sbjct: 938 MEATGCTRRLVVQQAGQADAGEYSCEA 964
Score = 38.1 bits (87), Expect = 0.056
Identities = 66/319 (20%), Positives = 118/319 (36%), Gaps = 41/319 (12%)
Query: 225 NHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGT 284
+H+L + +A Q EA G SS ++L E P F +KL + V E +
Sbjct: 1952 SHSLTISDLVLEDAGQITVEAEGA-----SSSAALRVREA---PVLFKKKLEPQTVEERS 2003
Query: 285 RVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
V L+ + + P P++RW L ++ I G H L + D G + C
Sbjct: 2004 SVTLE-VELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCETP 2062
Query: 345 NIYGTDSTSAEIYIE--------GVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPP 396
+ D T A++ +E G+ + ++ + M +V T +
Sbjct: 2063 D----DKTQAKLTVEMRQVRLVRGLQAVEAR-EQGTATMEVQLSHADVDGSWTRDGLRFQ 2117
Query: 397 AVPQAQHLVAQP-RVATIQQCQSPTNYLQGLDGKPIIAA--------PV-FTKMLQNLSA 446
P V P T+ + + L + + + PV F++ LQ++
Sbjct: 2118 QGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEGVHTSARLVVTELPVSFSRPLQDVVT 2177
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
+E + V EC + P+ V W ++G + K ++A +L I
Sbjct: 2178 TEKEKVTLECEL-SRPNVDVRWLKDGV--------ELRAGKTMAIAAQGACRSLTIYRCE 2228
Query: 507 AEDSGCFTCTASNKYGTVS 525
D G + C A + + S
Sbjct: 2229 FADQGVYVCDAHDAQSSAS 2247
Score = 38.1 bits (87), Expect = 0.056
Identities = 50/245 (20%), Positives = 92/245 (37%), Gaps = 41/245 (16%)
Query: 254 SSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
+S +SL E +P + L + V G V+L C + P V W + K + S
Sbjct: 2815 TSKASLIVRE---RPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQ 2870
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
+V G + L I A +D G Y+C ++A +++E + + E
Sbjct: 2871 KYDVVCEGTMAMLVIRGASLKDAGEYTCEVE----ASKSTASLHVE------EKANCFTE 2920
Query: 374 EMNRIQKPNEVSSPPTTSAVIPPAV-----------------PQAQHLVAQPRVATIQQC 416
E+ +Q + ++ T P A P + L + ++ +++
Sbjct: 2921 ELTNLQVEEKGTAVFTCKTEHPAATVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKA 2980
Query: 417 QSPTNYLQGLDGKPIIAAPVFT--------KMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
S T Y + G+ A + + L+++ EG F CR+ A V W
Sbjct: 2981 DSDT-YTCDI-GQAQSRAQLLVQGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHW 3038
Query: 469 YREGT 473
+ + T
Sbjct: 3039 FLDKT 3043
Score = 38.1 bits (87), Expect = 0.056
Identities = 70/316 (22%), Positives = 113/316 (35%), Gaps = 67/316 (21%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P +F KLR++E EG L C + P V W + L + + Q G + L
Sbjct: 3273 PAQFIGKLRNKEATEGATATLRCELSKAAP--VEWRKGSETLRDGDRYCLRQDGAMCELQ 3330
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV-SS 386
I D YSC + G + TSA + I + + + R++ + +
Sbjct: 3331 IRGLAMVDAAEYSC----VCGEERTSASLTIRPMPA---------HFIGRLRHQESIEGA 3377
Query: 387 PPTTSAVIPPAVPQA------------QHLVAQP-RVATIQQC----------------- 416
T + A P +H + Q V +Q C
Sbjct: 3378 TATLRCELSKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEE 3437
Query: 417 -QSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRV-KGAPSPKVEWYREGTL 474
S T ++ L K FT+ L+N A EG + C + K AP VEW +
Sbjct: 3438 RTSATLTVKALPAK-------FTEGLRNEEAVEGATAMLWCELSKVAP---VEWRKGPEN 3487
Query: 475 IEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS-SIAQLHVR 533
+ D + + Q+ R C L I + D+G + C + + + +I L R
Sbjct: 3488 LRDGDRYILRQEGTR--------CELQICGLAMADAGEYLCVCGQERTSATLTIRALPAR 3539
Query: 534 GNEDLSNNGSLHSANS 549
ED+ N + A +
Sbjct: 3540 FIEDVKNQEAREGATA 3555
Score = 37.7 bits (86), Expect = 0.073
Identities = 33/143 (23%), Positives = 65/143 (45%), Gaps = 11/143 (7%)
Query: 1104 LTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
+TWL +G+ + P +++ G LL+ + + DAG Y+C+ ++ G+ ++ L +
Sbjct: 737 VTWLKDGRTLSPGPKYEVQA-SAGRRVLLVRDVARDDAGLYECV--SRGGRIAYQLSVQG 793
Query: 1164 VAKEVKKAPVILEKLQNC-GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMH 1222
+A+ + K + +C G P + EC V +W KD + + ER +
Sbjct: 794 LARFLHK-----DMAGSCVDAVAGGPAQFECETSEAHVHV-HWYKDGMELGHSGERF-LQ 846
Query: 1223 QDTTGYACLLIQPAKKSDAGWYT 1245
+D L+ + D G Y+
Sbjct: 847 EDVGTRHRLVAATVTRQDEGTYS 869
Score = 37.0 bits (84), Expect = 0.13
Identities = 79/389 (20%), Positives = 142/389 (36%), Gaps = 45/389 (11%)
Query: 167 SHSSKRIRPRACKNHKSKLESQNKVMQENSSSFS-DLS---ERRERSSVPIPIPADTRDN 222
+HSS + A + + + +E +SFS +LS E E S +P+ D+ +
Sbjct: 2545 AHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLYNDSF-H 2603
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE 282
E++H + + ++A + + S+ + L E +P F + L E
Sbjct: 2604 EISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARL---EVRVKPVVFLKALDDLSAEE 2660
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
+ L C V P V W +G +L S + L + + ED G Y+C
Sbjct: 2661 RGTLALQC-EVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCH 2719
Query: 343 ASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMN------RIQKPNEVSSPPTT------ 390
G++ T A + + + ++ E + +E +S P
Sbjct: 2720 V----GSEETRARVRVHDLHVGITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGK 2775
Query: 391 ---SAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAA----PVFTKMLQN 443
S+ A Q + + R A ++GL K + K L++
Sbjct: 2776 TVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLED 2835
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
+ G+ V C + A +P V W ++ I S + ++ + +M LVI
Sbjct: 2836 QWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQKYDVVCEGTMAM--------LVIR 2886
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+D+G +TC S A LHV
Sbjct: 2887 GASLKDAGEYTCEVE----ASKSTASLHV 2911
Score = 36.6 bits (83), Expect = 0.16
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+P F+++L + EG + L C P V W +GK L S + G+ L
Sbjct: 3094 KPSVFSRELTDATITEGEDLTLVCETSTCDIP-VCWTKDGKTLRGSARCQLSHEGHRAQL 3152
Query: 327 TIAEAFEEDTGRYSCFA 343
I A +D+GRY C A
Sbjct: 3153 LITGATLQDSGRYKCEA 3169
Score = 36.6 bits (83), Expect = 0.16
Identities = 27/107 (25%), Positives = 42/107 (39%), Gaps = 1/107 (0%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F + L V G VT C++ P + W KDG + + + +
Sbjct: 7462 APTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPL-ESSSRVLISATLKNFQL 7520
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQ 1050
L I ++D G YT +N G ++ +G L P S G+
Sbjct: 7521 LTILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDIGE 7567
Score = 35.0 bits (79), Expect = 0.48
Identities = 42/169 (24%), Positives = 73/169 (43%), Gaps = 11/169 (6%)
Query: 1084 AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGV-HSLLIDPLTQRDAG 1142
A EG +C++S TWLL+ +PV + +++ E G+ H LL+ L +D+
Sbjct: 4351 ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDS- 4409
Query: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI-GMPPP 1201
C T G S L+V ++ ILE L+N V G C + +P
Sbjct: 4410 ---CRVTFLAGDMVTSAFLTVRGWRLE----ILEPLKNAAVRAGAQACFTCTLSEAVPVG 4462
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
W + + ++ D + +A LL++ A+ AG T + ++
Sbjct: 4463 EASWYINGAAVQPDDSDWTVTADGSHHA-LLLRSAQPHHAGEVTFACRD 4510
Score = 34.3 bits (77), Expect = 0.81
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 3/98 (3%)
Query: 1164 VAKEVKK--APVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISM 1221
V KE+K+ P+ + G +RLEC V W KD + R +
Sbjct: 4888 VRKEMKQQEGPMFSHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHH-HI 4946
Query: 1222 HQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTA 1259
Q G LLI ++DAG YT N+ G V+ +A
Sbjct: 4947 DQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSA 4984
Score = 33.5 bits (75), Expect = 1.4
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 5/73 (6%)
Query: 278 REVPEGTRVQLD-----CIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAF 332
R++P T V++ C+ + +P V W +E+ + I G H+LTI++
Sbjct: 424 RKLPRKTAVRVGDTAMFCVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCC 483
Query: 333 EEDTGRYSCFASN 345
ED G+ + A +
Sbjct: 484 LEDVGQVAFMAGD 496
Score = 33.5 bits (75), Expect = 1.4
Identities = 55/247 (22%), Positives = 90/247 (36%), Gaps = 47/247 (19%)
Query: 300 VRWYCEGKELENSPDIHIVQ-AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
V WY +G EL +S + + + G H L A +D G YSC G DS + +
Sbjct: 828 VHWYKDGMELGHSGERFLQEDVGTRHRLVAATVTRQDEGTYSCRV----GEDSVDFRLRV 883
Query: 359 EGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQ------AQHLVAQPRVA- 411
S+ + KE++ R + E + T S + A + + L + +V
Sbjct: 884 -----SEPKVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCM 938
Query: 412 ---------TIQQ----------CQSPTNYLQ-GLDGK-PIIAAPVFTKMLQNLSASEGQ 450
+QQ C++ L LD K P + + A G
Sbjct: 939 EATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGA 998
Query: 451 LVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDS 510
C V A + +V WY++G + S + K R LV+ + D+
Sbjct: 999 SATLSCEVAQAQT-EVMWYKDGKKLSSSLKVHVEAKGCRR--------RLVVQQAGKTDA 1049
Query: 511 GCFTCTA 517
G ++C A
Sbjct: 1050 GDYSCEA 1056
Score = 31.6 bits (70), Expect = 5.3
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVR 1124
L R +R L+ + G C +S +P E +W +NG V PD S +
Sbjct: 4425 LTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTA 4484
Query: 1125 ETGVHSLLIDPLTQRDAG--TYKC 1146
+ H+LL+ AG T+ C
Sbjct: 4485 DGSHHALLLRSAQPHHAGEVTFAC 4508
Score = 31.2 bits (69), Expect = 6.9
Identities = 25/94 (26%), Positives = 35/94 (37%), Gaps = 1/94 (1%)
Query: 248 GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK 307
G P P ++ EP P SR+V G V L+ VV +V W+ +
Sbjct: 4603 GAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVA-EAGEVIWHKGME 4661
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
++ +V G L I ED G Y C
Sbjct: 4662 RIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHC 4695
Score = 30.8 bits (68), Expect = 9.0
Identities = 26/93 (27%), Positives = 36/93 (38%), Gaps = 7/93 (7%)
Query: 765 VSHP--SVQTKSPGGLSIQNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIP-VSPTS 821
+ HP S Q S GG +P P P P P F P SP P V+P
Sbjct: 6998 MGHPQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGCSPHPAVAPCP 7057
Query: 822 RIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPS 854
P +F P +P + +G P++ P+
Sbjct: 7058 ----PGSFPPGSCKEAPLVPSSPFLGQPQAPPA 7086
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 113 bits (282), Expect = 1e-24
Identities = 154/671 (22%), Positives = 269/671 (40%), Gaps = 112/671 (16%)
Query: 636 ATKTPEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQHQLQNPPPSSPKEFP---FSM 692
+T+T P++ P V+ TQ ++ Q + + + Q + P P
Sbjct: 1313 STQTAIPATTPTFPASVITY----ETQTERSRAQTIQREQEPQKKNRTDPNISPDQSSGF 1368
Query: 693 TVLNSNAPPAVTTSSKQVKAPSSQTFSLARPKYFFPSTNTTAATVAPSSSPVFTLS---- 748
T + PP +TT+ VK PS F+ + P+ +T ++T++ S +
Sbjct: 1369 TTPTAMTPPVLTTAETSVK-PSVSAFTHSPPE----NTTGISSTISFHSRTLNLTDVIEE 1423
Query: 749 ---STPQTIQRTVSKESLLVS--HPSVQTKSPGGLSIQNEPLPPGPTE-------PTPPP 796
++ QT++ T++ E+ L S H S T+ I++ +PP + P PP
Sbjct: 1424 LAQASTQTLKSTIASETTLSSKSHQSTTTRKA---IIRHSTIPPFLSSSATLMPVPISPP 1480
Query: 797 FTFSIPSGNQFQP----RCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAM------ 846
FT + N P + + + +SR L + + + P + P
Sbjct: 1481 FTQRAVTDNVATPISGLMTNTVVKLHESSRHNAKPQQLVAEVATSPKVHPNAKFTIGTTH 1540
Query: 847 ----GLPRSAPSMPSQGLAKKNTK-SPQPVNDDNIRETKNAVIRDLGKKITFSDVRP--- 898
L S P + +N+K +P P ++ + I + GKK S +
Sbjct: 1541 FIYSNLLHSTPMPALTTVKSQNSKLTPSPWAENQFWHKPYSEIAEKGKKPEVSMLATTGL 1600
Query: 899 NQQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDK------RLK 952
++ +S ++ + N + ++ PV E+ +P IF+K +
Sbjct: 1601 SEATTLVSDWDGQ-KNTKKSDFDKKPVQEATTS---KLLPFDSLSRYIFEKPRIVGGKAA 1656
Query: 953 HFRVTEGSPVTFTCKIVGIPVPKVYWFK--DGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
F + S C+ VG P+P ++W + G +SKR ++ +++ +GT L I+
Sbjct: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT--LSIQRVE 1714
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D G Y A+N G L V S P R ++ R KE
Sbjct: 1715 IQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRI--------------LERRTKE------ 1754
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA---SHKMLVRETG 1127
+ H G L C+ G P P +TW+L Q V+ ++ S + +V G
Sbjct: 1755 -----------ITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDG 1803
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPE-G 1186
+L++ L+ D G YKC+A+N GQ+S +++ V+A PVILE+ + V G
Sbjct: 1804 --TLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIA----APPVILEQRRQVIVGTWG 1857
Query: 1187 HPVRLECRVIGMPPPVFYWKKDNET----IPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
++L C G P P YW + T + T ++ + + T L I+ SD G
Sbjct: 1858 ESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT----LYIRNLASSDRG 1913
Query: 1243 WYTLSAKNEAG 1253
Y A + G
Sbjct: 1914 TYECIATSSTG 1924
Score = 83.6 bits (205), Expect = 1e-15
Identities = 87/334 (26%), Positives = 136/334 (40%), Gaps = 55/334 (16%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYW-FKDGKQISKRNE-----HCKMRRE 997
A I K+ +V G CK G PVP++ W DG I+ + H R
Sbjct: 2038 AKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYT 2097
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR 1057
+L+ ++G+YT A N G+ HL V + R R QS++ R
Sbjct: 2098 LFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIR-----QSNKTNKR 2152
Query: 1058 VQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA 1117
++ D L DC+V+G P P++ WLL ++ +
Sbjct: 2153 IKAGDTAVL--------------------------DCEVTGDPKPKIFWLLPSNDMISFS 2186
Query: 1118 SHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEK 1177
+ G SL I+ + D+G Y C+A N +G ++ +L VV+ K P+I
Sbjct: 2187 IDRYTFHANG--SLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVS----KPPLINGL 2240
Query: 1178 LQNCGVPEGHPVR-----LECRVIGMPPPVFYW-KKDN--ETIPCTRERISMHQDTTGYA 1229
N V + VR +CR G P P W DN T P RI++H++ T
Sbjct: 2241 YTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT--- 2297
Query: 1230 CLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
L I+ + SD+ + A+NE G +L++
Sbjct: 2298 -LEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
Score = 77.8 bits (190), Expect = 6e-14
Identities = 79/325 (24%), Positives = 128/325 (39%), Gaps = 50/325 (15%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
K V G + C G P P++ W K + + SL I S T
Sbjct: 1949 KRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTE 2008
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071
D G Y +A N G H+ + RL A H+ ++F
Sbjct: 2009 KDSGVYLCVARNKMGDDLILMHVSL-------RLKPAKIDHK---------------QYF 2046
Query: 1072 RPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTW------LLNGQPVLPDASHKMLVRE 1125
R L G+ ++DCK SG P PE++W ++N D+ H+ R
Sbjct: 2047 RKQVLH---------GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTR-RY 2096
Query: 1126 TGVHS--LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ-NCG 1182
T ++ L + + + G Y C A N G++ + L+V+ AP I + + N
Sbjct: 2097 TLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA----APRIRQSNKTNKR 2152
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWK-KDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
+ G L+C V G P P +W N+ I + +R + H + + L I K D+
Sbjct: 2153 IKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGS----LTINKVKLLDS 2208
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQ 1266
G Y A+N +G + +LD+ ++
Sbjct: 2209 GEYVCVARNPSGDDTKMYKLDVVSK 2233
Score = 75.5 bits (184), Expect = 3e-13
Identities = 85/327 (25%), Positives = 130/327 (39%), Gaps = 56/327 (17%)
Query: 964 FTCKIVGIPVPKVYWFK-DGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAA 1022
F C+ G P P+V W D ++ ++ +GT L I + D ++ +A
Sbjct: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGT--LEIRNVRLSDSADFICVAR 2316
Query: 1023 NPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDM 1082
N G ++V L + E L+ FR F + +
Sbjct: 2317 NEGGE-----SVLVVQLEVL---------------------EMLRRPTFRNPFNEK---I 2347
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDA--SHKMLVRETGVHSLLIDPLTQRD 1140
VA G+ L+C V G PPPE+ W+L + S++ L+ G S +I T+ D
Sbjct: 2348 VAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG--SFIISKTTRED 2405
Query: 1141 AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC--GVPEGHPVRLECRVIGM 1198
AG Y+C A NK G +V E+ + PVIL G+ G + L C G+
Sbjct: 2406 AGKYRCAARNKVGYIE-----KLVILEIGQKPVILTYAPGTVKGI-SGESLSLHCVSDGI 2459
Query: 1199 PPPVFYWKKDNETI---PCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
P P W + + P + +H + T L+I+ A D G Y A+N G
Sbjct: 2460 PKPNIKWTMPSGYVVDRPQINGKYILHDNGT----LVIKEATAYDRGNYICKAQNSVGHT 2515
Query: 1256 SCTARLDIYAQWHHQIPPPMSVRPSGS 1282
T + I A PP ++ RP S
Sbjct: 2516 LITVPVMIVA-----YPPRITNRPPRS 2537
Score = 73.6 bits (179), Expect = 1e-12
Identities = 79/325 (24%), Positives = 133/325 (40%), Gaps = 59/325 (18%)
Query: 946 IFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYW-FKDGKQISKRN-EHCKMRREGDGTCS 1003
I ++R + T G + C G P P VYW DG ++ + K+ +GT
Sbjct: 1844 ILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT-- 1901
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
L+I + S D G Y +A + G V L + R+TS R++ +
Sbjct: 1902 LYIRNLASSDRGTYECIATSSTG-----SERRVVMLTMEERVTSP--------RIEAASQ 1948
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
+ + F GD + L+C +G P P++ W L + V+ D H++
Sbjct: 1949 KRTEVNF---------GDKLL-------LNCSATGEPKPQIMWRLPSKAVV-DQQHRV-- 1989
Query: 1124 RETGVH-----SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
+ +H SL I +T++D+G Y C+A NK G + L L V+ +K A + ++
Sbjct: 1990 -GSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDD---LILMHVSLRLKPAKIDHKQY 2045
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGY---------- 1228
V G +++C+ G P P W + T+ +M D +G+
Sbjct: 2046 FRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTM----INNAMQADDSGHRTRRYTLFNN 2101
Query: 1229 ACLLIQPAKKSDAGWYTLSAKNEAG 1253
L ++ G YT A+N G
Sbjct: 2102 GTLYFNKVGVAEEGDYTCYAQNTLG 2126
Score = 73.2 bits (178), Expect = 2e-12
Identities = 69/300 (23%), Positives = 112/300 (37%), Gaps = 44/300 (14%)
Query: 959 GSPVTFTCKIVGIPVPKVYWF-KDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
G C + G P P++ W +G + S + + +G S I TT +D G Y
Sbjct: 2352 GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG--SFIISKTTREDAGKY 2409
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
A N G I L + P+
Sbjct: 2410 RCAARNKVGYIEKLVILEIGQKPVI--------------------------------LTY 2437
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL--PDASHKMLVRETGVHSLLIDP 1135
APG + G L C G+P P + W + V+ P + K ++ + G +L+I
Sbjct: 2438 APGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG--TLVIKE 2495
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
T D G Y C A N G ++ + +VA + + ++ G +L C
Sbjct: 2496 ATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPR---ITNRPPRSIVTRTGAAFQLHCVA 2552
Query: 1196 IGMPPPVFYWKKDNETIPCT--RERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+G+P P W+ + ++ T +ER + L+IQ + SD+G Y +AKN G
Sbjct: 2553 LGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
Score = 57.8 bits (138), Expect = 7e-08
Identities = 68/295 (23%), Positives = 105/295 (35%), Gaps = 58/295 (19%)
Query: 269 PRFTQKLRSREVPE-GTRVQLDCIVVGIPPPQVRWYC-EGKELENSPDIHIVQAGNLHSL 326
P F + V + G L+C V G PPP++ W G N P + + S
Sbjct: 2337 PTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSF 2396
Query: 327 TIAEAFEEDTGRYSCFASNIYG--------------TDSTSAEIYIEGVSSSD------S 366
I++ ED G+Y C A N G T A ++G+S S
Sbjct: 2397 IISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVS 2456
Query: 367 EGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQS--PTNYL- 423
+G P KPN + P+ V P + ++++ I++ + NY+
Sbjct: 2457 DGIP---------KPNIKWTMPSGYVVDRPQI-NGKYILHDNGTLVIKEATAYDRGNYIC 2506
Query: 424 --QGLDGKPIIAAPVF---------TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
Q G +I PV + +++ G C G P P++ W
Sbjct: 2507 KAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITW---- 2562
Query: 473 TLIEDSPDFRILQKKPRSMAEPEEIC----TLVIAEVFAEDSGCFTCTASNKYGT 523
+ PD +L + E TLVI DSG + CTA N G+
Sbjct: 2563 ----EMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
Score = 57.4 bits (137), Expect = 9e-08
Identities = 53/210 (25%), Positives = 83/210 (39%), Gaps = 37/210 (17%)
Query: 959 GSPVTFTCKIVGIPVPKVYW-FKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
G ++ C GIP P + W G + + + K +GT L I+ T+ D GNY
Sbjct: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT--LVIKEATAYDRGNY 2504
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
A N G + +M+ + P R+T+ RP
Sbjct: 2505 ICKAQNSVGHTLITVPVMIVAYP--PRITN------------------------RP---- 2534
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVH---SLLID 1134
P +V G +L C G+P PE+TW + +L AS + +H +L+I
Sbjct: 2535 -PRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQ 2593
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
D+G YKC A N G + + + V+
Sbjct: 2594 NPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
Score = 55.1 bits (131), Expect = 4e-07
Identities = 48/176 (27%), Positives = 71/176 (40%), Gaps = 6/176 (3%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPV-LPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
L C+ G P P + W + L V+ +L I + +D G Y C A+N
Sbjct: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEK-LQNCGVPEGHPVRLECRVIGMPPPVFYWKKDN 1209
G + + LSVV+ P ILE+ + V G V L+CR G P P W N
Sbjct: 1728 LFGTDHLHVTLSVVSYP----PRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILAN 1783
Query: 1210 ETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYA 1265
+T+ + S T L++ D G+Y A N G S ++ + A
Sbjct: 1784 QTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVIA 1839
Score = 50.8 bits (120), Expect = 8e-06
Identities = 93/400 (23%), Positives = 146/400 (36%), Gaps = 52/400 (13%)
Query: 168 HSSKRIRPRACKNHKSKLESQNKVMQENSSSFSDLSERRERSSVP-IPIPADTRDNEVNH 226
HS+ K+ SKL EN SE E+ P + + A T +E
Sbjct: 1548 HSTPMPALTTVKSQNSKLTPSP--WAENQFWHKPYSEIAEKGKKPEVSMLATTGLSEATT 1605
Query: 227 ALE----QQEAKRREAEQA-ASEAAGGDTTPGSSPSSLYYEEPL---GQPPRFTQKLRSR 278
+ Q+ K+ + ++ EA P S S +E+P G+ FT
Sbjct: 1606 LVSDWDGQKNTKKSDFDKKPVQEATTSKLLPFDSLSRYIFEKPRIVGGKAASFT------ 1659
Query: 279 EVPEGTRVQLDCIVVGIPPPQVRW--YCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT 336
+P + L C VG P P + W G +L VQ +L+I +D
Sbjct: 1660 -IPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDR 1718
Query: 337 GRYSCFASNIYGTD-----------------STSAEIYIEGVSSSD----SEGDPNKEEM 375
G+Y C ASN++GTD + EI + S+ + +EG P+
Sbjct: 1719 GQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVT 1778
Query: 376 NRIQKPNEV--SSPPTTSAVIPPAVPQAQH-LVAQPRVATIQQCQSPTNYLQGLDGKPII 432
+ V SS + AV+ H L R +P L +I
Sbjct: 1779 WILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQVI 1838
Query: 433 AAP--VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS 490
AAP + + Q + + G+ + C KG P P V W ++ D + + LQ S
Sbjct: 1839 AAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYW-----VLSDGTEVKPLQ-FTNS 1892
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
TL I + + D G + C A++ G+ + L
Sbjct: 1893 KLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
Score = 46.6 bits (109), Expect = 2e-04
Identities = 61/271 (22%), Positives = 103/271 (38%), Gaps = 51/271 (18%)
Query: 912 LMNEIEFRLERTPVDESDDEIQHDE-----IPTGKCIAPIFDK----------RLKHFRV 956
+ ++I +L RT S +IQ+ +P + + P+ K +L+H V
Sbjct: 430 MQDQISLQLNRTATTFSTLQIQYSSDAQITLPRAE-MRPVKHKWTMISRDNNTKLEH-TV 487
Query: 957 TEGSPVTFTCKIVGIPVPKVYWF-KDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
G V C G P P V W DG ++ R D + L ++ S D G
Sbjct: 488 LVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTG 547
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y +++N ++ + + L A Q + V F
Sbjct: 548 VYHCISSNYD-----DADILTYRITVVEPLVEAYQENGIHHTV----------------F 586
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
+ G L C +G+P ++W++ G VL +S V G +L I
Sbjct: 587 I----------GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG--TLRILQ 634
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAK 1166
+T +D G Y+C+A N +G + ++SV K
Sbjct: 635 VTPKDQGYYRCVAANPSGVDFLIFQVSVKMK 665
Score = 45.1 bits (105), Expect = 5e-04
Identities = 76/319 (23%), Positives = 111/319 (34%), Gaps = 49/319 (15%)
Query: 259 LYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPD---- 314
L EE + P + EV G ++ L+C G P PQ+ W K + +
Sbjct: 1932 LTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGS 1991
Query: 315 -IHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE-GVSSSDSEGDPNK 372
IH+ G SL I E+D+G Y C A N G D + + + D + K
Sbjct: 1992 WIHVYPNG---SLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRK 2048
Query: 373 EEMN----RIQKPNEVSSPPTTSAVIPPA-----VPQAQHLVAQPRVAT----------- 412
+ ++ ++ S P S +P QA + R T
Sbjct: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
Query: 413 --IQQCQSPTNYLQGLDGKP--------IIAAP-VFTKMLQNLSASEGQLVVFECRVKGA 461
+ + T Y Q GK I AAP + N G V +C V G
Sbjct: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGD 2168
Query: 462 PSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKY 521
P PK+ W D F I + + +L I +V DSG + C A N
Sbjct: 2169 PKPKIFWLLPS---NDMISFSIDRYTFHANG------SLTINKVKLLDSGEYVCVARNPS 2219
Query: 522 GTVSSIAQLHVRGNEDLSN 540
G + + +L V L N
Sbjct: 2220 GDDTKMYKLDVVSKPPLIN 2238
Score = 45.1 bits (105), Expect = 5e-04
Identities = 63/299 (21%), Positives = 112/299 (37%), Gaps = 46/299 (15%)
Query: 269 PRFTQKLRS-REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELEN-SPDIHIVQAGNLHSL 326
PR Q ++ + + G LDC V G P P++ W ++ + S D + A SL
Sbjct: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANG--SL 2198
Query: 327 TIAEAFEEDTGRYSCFASN-------IYGTDSTSAEIYIEGVSSSDS------------- 366
TI + D+G Y C A N +Y D S I G+ ++ +
Sbjct: 2199 TINKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
Query: 367 -----EGDPNKEEMNRIQKPNEVSSPPTTSAVIPPA-----VPQAQHLVAQPRVATIQQC 416
EG P+ E M + +++P S + + + + + +
Sbjct: 2259 FDCRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNE 2318
Query: 417 QSPTNYLQGLDGKPIIAAPVFTKML-QNLSASEGQLVVFECRVKGAPSPKVEWYR-EGTL 474
+ + L+ ++ P F + + A G+ C V G P P++ W GT
Sbjct: 2319 GGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTR 2378
Query: 475 IEDSPD-FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ P ++ L S +I++ ED+G + C A NK G + + L +
Sbjct: 2379 FSNGPQSYQYLIASNGSF---------IISKTTREDAGKYRCAARNKVGYIEKLVILEI 2428
Score = 44.7 bits (104), Expect = 6e-04
Identities = 62/293 (21%), Positives = 103/293 (35%), Gaps = 48/293 (16%)
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYC-EGKELENSPDIH----------IVQAGNLHSL 326
++V G Q+DC G P P++ W +G + N+ + G L+
Sbjct: 2048 KQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFN 2107
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI---------------------EGVSSSD 365
+ A E D Y+C+A N G D + + V +
Sbjct: 2108 KVGVAEEGD---YTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCE 2164
Query: 366 SEGDPNKEEMNRIQKPNEVS---SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNY 422
GDP + + + +S T A + + + L + V +
Sbjct: 2165 VTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTK 2224
Query: 423 LQGLD--GKPIIAAPVFT-KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ LD KP + ++T + + +A F+CR +G PSP+V W + +P
Sbjct: 2225 MYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAP 2284
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ S + TL I V DS F C A N+ G + QL V
Sbjct: 2285 YY-------GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
Score = 42.7 bits (99), Expect = 0.002
Identities = 28/96 (29%), Positives = 41/96 (42%), Gaps = 5/96 (5%)
Query: 268 PPRFTQKL-RSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAG-NLH- 324
PPR T + RS G QL C+ +G+P P++ W L ++ LH
Sbjct: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHL 2586
Query: 325 --SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI 358
+L I D+G Y C A N G+D + I +
Sbjct: 2587 QGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 42.0 bits (97), Expect = 0.004
Identities = 65/309 (21%), Positives = 110/309 (35%), Gaps = 51/309 (16%)
Query: 252 PGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQ-----LDCIVVGIPPPQVRWYCEG 306
P + +Y + + +PP +R V + T V+ DC G P P+V W
Sbjct: 2218 PSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPD 2277
Query: 307 KELENSP----DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS 362
+P I + + G +L I D+ + C A N G ++ + +
Sbjct: 2278 NIFLTAPYYGSRITVHKNG---TLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEML 2334
Query: 363 SSDSEGDP-NKEEMNRIQKPNEV------SSPPTTSAVIPPAV-----PQA-QHLVAQPR 409
+ +P N++ + ++ K + + PP ++P PQ+ Q+L+A
Sbjct: 2335 RRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNG 2394
Query: 410 VATIQQ------------CQSPTNYLQGLDGKPIIAAPV-FTKMLQNLSASEGQLVVFEC 456
I + ++ Y++ L I PV T + G+ + C
Sbjct: 2395 SFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHC 2454
Query: 457 RVKGAPSPKVEWYREGTLIEDSPDFR---ILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
G P P ++W + D P IL TLVI E A D G +
Sbjct: 2455 VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNG----------TLVIKEATAYDRGNY 2504
Query: 514 TCTASNKYG 522
C A N G
Sbjct: 2505 ICKAQNSVG 2513
Score = 41.2 bits (95), Expect = 0.007
Identities = 43/173 (24%), Positives = 72/173 (41%), Gaps = 24/173 (13%)
Query: 1092 LDCKVSGLPPPELTWLL-NGQPV-LPDASH--KMLVRETGVHSLLIDPLTQRDAGTYKCI 1147
L+C G P P + WLL +G V P S ++L+ ++G L + D G Y CI
Sbjct: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSG--KLELQMADSFDTGVYHCI 552
Query: 1148 ATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPE----GHPVRLECRVIGMPPPVF 1203
++N + + ++VV ++E Q G+ G + L C G+P
Sbjct: 553 SSNYDDADILTYRITVVEP-------LVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
Query: 1204 YW--KKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
W +N +R++ ++ T L I D G+Y A N +G+
Sbjct: 606 SWVIPGNNVLYQSSRDKKVLNNGT-----LRILQVTPKDQGYYRCVAANPSGV 653
Score = 40.4 bits (93), Expect = 0.011
Identities = 55/254 (21%), Positives = 87/254 (34%), Gaps = 45/254 (17%)
Query: 449 GQLVVFECRVKGAPSPKVEWYREGT--LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
G+ + C G P + W G L + S D ++L TL I +V
Sbjct: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNG-----------TLRILQVT 636
Query: 507 AEDSGCFTCTASNKYGTVSSIAQLHV--RGNEDLSNNGSLHSANSTTNLAAIEPQPSPPH 564
+D G + C A+N G I Q+ V +G L ++G T E P
Sbjct: 637 PKDQGYYRCVAANPSGVDFLIFQVSVKMKGQRPLEHDG------ETEGSGLDESNPIAHL 690
Query: 565 SEPPSVEQPPKPKLEGVLVNHNEPRSS---------SRIGLRVHFNLPEDDKGSEASSEA 615
EPP + +E + H S R G H E+ + S+
Sbjct: 691 KEPPGAQLRTSALMEAEVGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSA-- 748
Query: 616 GVVTTRQTRPD---SFQERFNGQATKTPEPSSPVKEPPPVLAKPKL-----DSTQLQQLH 667
R+ P + E+ A ++ V PP V P + DS+ + LH
Sbjct: 749 -----RRIDPQHWAALLEKAKKNAMPDKRENTTVSPPPVVTQLPNIPGEEDDSSGMLALH 803
Query: 668 NQVLLEQHQLQNPP 681
+ ++ + N P
Sbjct: 804 EEFMVPATKALNLP 817
Score = 38.5 bits (88), Expect = 0.043
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 21/146 (14%)
Query: 456 CRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTC 515
C G P P + W R + ++ S ++K S + TL I V +D G + C
Sbjct: 1670 CEAVGNPLPTIHWTRVPSGLDLS------KRKQNSRVQVLPNGTLSIQRVEIQDRGQYLC 1723
Query: 516 TASNKYGT-----VSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPP------- 563
+ASN +GT S+ R E + ++HS ++ E +PSP
Sbjct: 1724 SASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILAN 1783
Query: 564 ---HSEPPSVEQPPKPKLEGVLVNHN 586
SE + ++G LV HN
Sbjct: 1784 QTVVSESSQGSRQAVVTVDGTLVLHN 1809
Score = 38.5 bits (88), Expect = 0.043
Identities = 56/279 (20%), Positives = 91/279 (32%), Gaps = 84/279 (30%)
Query: 250 TTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPE-GTRVQLDCIVVGIPPPQVRW-YCEGK 307
+ PG S L + + PP ++ R V G ++L C G P P V W +G
Sbjct: 1823 SNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGT 1882
Query: 308 ELE----NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS 363
E++ + + + G L+ +A + D G Y C A++ G++ + +E
Sbjct: 1883 EVKPLQFTNSKLFLFSNGTLYIRNLASS---DRGTYECIATSSTGSERRVVMLTME---- 1935
Query: 364 SDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYL 423
V PR+ Q ++ N+
Sbjct: 1936 ---------------------------------------ERVTSPRIEAASQKRTEVNF- 1955
Query: 424 QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
K+L N SA+ G P P++ W + D
Sbjct: 1956 -------------GDKLLLNCSAT------------GEPKPQIMWRLPSKAVVDQ----- 1985
Query: 484 LQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
Q + S +L I V +DSG + C A NK G
Sbjct: 1986 -QHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
Score = 37.7 bits (86), Expect = 0.073
Identities = 25/98 (25%), Positives = 45/98 (45%), Gaps = 8/98 (8%)
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEW-YREGTLIEDSPDFRILQKKPRSMAEP 494
+ + + ++ G V +CR +G PSP V W T++ +S Q +++
Sbjct: 1747 ILERRTKEITVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESS-----QGSRQAVVTV 1801
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ TLV+ + D G + C ASN G S + ++ V
Sbjct: 1802 DG--TLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQV 1837
Score = 37.0 bits (84), Expect = 0.13
Identities = 25/110 (22%), Positives = 44/110 (40%), Gaps = 7/110 (6%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
G + L C GIP + W G + ++S D ++ G L L + +D G Y
Sbjct: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTP---KDQGYYR 644
Query: 341 CFASNIYGTDST--SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
C A+N G D + ++G + +G+ ++ + PP
Sbjct: 645 CVAANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPP 694
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 112 bits (279), Expect = 3e-24
Identities = 143/566 (25%), Positives = 202/566 (35%), Gaps = 78/566 (13%)
Query: 739 PSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFT 798
P P+F+ STP+T R VS + PS K P G TEP P
Sbjct: 530 PGEPPLFSRPSTPKT-SRAVSPAAAQPPSPSSAEKPGDEPGRPRSRGPAGRTEPGEGPQQ 588
Query: 799 -------FSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMG-LPR 850
F + Q C SP+P +P + P PP A+ LP
Sbjct: 589 EVRRRDQFPLTRSRAIQ-ECRSPVPPPAA----DPPEARTKAPPGRKREPPAQAVRFLPW 643
Query: 851 SAPSMPSQGLAK---KNTKSPQ--------PVNDDNIRETKNAVIRDLGKKITFSDVRPN 899
+ P + + + KN P+ P D R GK RP
Sbjct: 644 ATPGLEGAAVPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQGKG---RRARPT 700
Query: 900 QQEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEG 959
E + S D + E P AP+F+ L++ V G
Sbjct: 701 SPELESSD---------------------DSYVSAGEEPLE---APVFEIPLQNVVVAPG 736
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
+ V C I P P+V W KDG + +R EG+ +L + + D G+Y
Sbjct: 737 ADVLLKCIITANPPPQVSWHKDGSALRSEGR-LLLRAEGERH-TLLLREARAADAGSYMA 794
Query: 1020 MAANPQGRISCSGHLMVQ----SLPIRSRLTSAGQ--------SHRGRS--RVQERDKEP 1065
A N G+ +C+ L V+ + P S +TS + G + R P
Sbjct: 795 TATNELGQATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGETWPRTPTMKPSP 854
Query: 1066 LQERFFRPHFLQAPG-------DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDAS 1118
Q R +AP D EG+ + +V G P P ++WL N QPV PD
Sbjct: 855 SQNRRSSDTGSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQR 914
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
E G+ L I + DAG Y C A N+ G L V A ++ +L L
Sbjct: 915 RFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPL 974
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYAC-LLIQPAK 1237
Q+ V G EC V G W + + MH D G C LL+
Sbjct: 975 QDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHFD--GRKCKLLLTSVH 1032
Query: 1238 KSDAGWYTLSAKNEAGIVSCTARLDI 1263
+ D+G YT ++C+ARL +
Sbjct: 1033 EDDSGVYTCKLSTAKDELTCSARLTV 1058
Score = 107 bits (266), Expect = 1e-22
Identities = 75/252 (29%), Positives = 120/252 (47%), Gaps = 24/252 (9%)
Query: 919 RLERTPVDESDDEIQHDEIPTGK-------------CIAPIFDKRLKHFRVTEGSPVTFT 965
+L T V E D + ++ T K +AP+F + L+ V EG F
Sbjct: 1025 KLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARFD 1084
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
CKI G P P V W G + + +E+ ++R++G G SLHI S+D+G Y + A N
Sbjct: 1085 CKISGTPPPVVTWTHFGCPMEE-SENLRLRQDG-GLHSLHIAHVGSEDEGLYAVSAVNTH 1142
Query: 1026 GRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQ---ERFFRPHFLQAPGDM 1082
G+ CS L V+ R ++G S + ++ +EP Q ER P FL+ D+
Sbjct: 1143 GQAHCSAQLYVE----EPRTAASGPSSK-LEKMPSIPEEPEQGELERLSIPDFLRPLQDL 1197
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAG 1142
+ L+C+V+GLP P ++W NG + + + + + VH L+ + + AG
Sbjct: 1198 EVGLAKEAMLECQVTGLPYPTISWFHNGHRI-QSSDDRRMTQYRDVHRLVFPAVGPQHAG 1256
Query: 1143 TYKCIATNKTGQ 1154
YK + NK G+
Sbjct: 1257 VYKSVIANKLGK 1268
Score = 106 bits (265), Expect = 1e-22
Identities = 72/264 (27%), Positives = 114/264 (43%), Gaps = 50/264 (18%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT+ L EV EG + DC + G PPP V W G +E S ++ + Q G LHSL I
Sbjct: 1064 PLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQDGGLHSLHI 1123
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
A ED G Y+ A N +G SA++Y+E +P +S P
Sbjct: 1124 AHVGSEDEGLYAVSAVNTHGQAHCSAQLYVE--------------------EPRTAASGP 1163
Query: 389 TTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASE 448
++ P++P+ +P +++ ++ P F + LQ+L
Sbjct: 1164 SSKLEKMPSIPE------EPEQGELER----------------LSIPDFLRPLQDLEVGL 1201
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ + EC+V G P P + W+ G I+ S D R M + ++ LV V +
Sbjct: 1202 AKEAMLECQVTGLPYPTISWFHNGHRIQSSDD--------RRMTQYRDVHRLVFPAVGPQ 1253
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
+G + +NK G + A L+V
Sbjct: 1254 HAGVYKSVIANKLGKAACYAHLYV 1277
Score = 105 bits (263), Expect = 2e-22
Identities = 88/310 (28%), Positives = 125/310 (40%), Gaps = 36/310 (11%)
Query: 230 QQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLD 289
+ + K R A + E D + S+ EEPL + P F L++ V G V L
Sbjct: 689 RSQGKGRRARPTSPELESSDDSYVSAG-----EEPL-EAPVFEIPLQNVVVAPGADVLLK 742
Query: 290 CIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
CI+ PPPQV W+ +G L + + + G H+L + EA D G Y A+N G
Sbjct: 743 CIITANPPPQVSWHKDGSALRSEGRLLLRAEGERHTLLLREARAADAGSYMATATNELGQ 802
Query: 350 DSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPR 409
+ +A + + S+ P + + P E P T PR
Sbjct: 803 ATCAASLTVRPGGSTSPFSSPITSDEEYLSPPEEFPEPGET----------------WPR 846
Query: 410 VATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWY 469
T++ S K A P F L + S EGQ V+ RV+G P P V W
Sbjct: 847 TPTMKPSPSQNRRSSDTGSK---APPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWL 903
Query: 470 REGTLIEDSPDFRILQKKPRSMAEPEE--ICTLVIAEVFAEDSGCFTCTASNKYGTVSSI 527
R + PD R AE E +C L I D+G +TC A N+YG
Sbjct: 904 RNRQPVR--PD-------QRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCE 954
Query: 528 AQLHVRGNED 537
A+L VR + +
Sbjct: 955 ARLEVRAHPE 964
Score = 94.7 bits (234), Expect = 5e-19
Identities = 91/355 (25%), Positives = 135/355 (38%), Gaps = 68/355 (19%)
Query: 934 HDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCK 993
H E + +AP+ D V G F C + G +V W G+ + CK
Sbjct: 962 HPESRSLAVLAPLQD-----VDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCK 1016
Query: 994 MRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHR 1053
M +G C L + S DD G YT + + ++CS L V+
Sbjct: 1017 MHFDGR-KCKLLLTSVHEDDSGVYTCKLSTAKDELTCSARLTVRPS-------------- 1061
Query: 1054 GRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV 1113
P F + D+ EGR R DCK+SG PPP +TW G P
Sbjct: 1062 -----------------LAPLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCP- 1103
Query: 1114 LPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV---------V 1164
+ ++ + L ++ G+HSL I + D G Y A N GQ S +L V
Sbjct: 1104 MEESENLRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGP 1163
Query: 1165 AKEVKKAPVI-----------------LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKK 1207
+ +++K P I L LQ+ V LEC+V G+P P W
Sbjct: 1164 SSKLEKMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFH 1223
Query: 1208 DNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ I + + R++ ++D + P AG Y N+ G +C A L
Sbjct: 1224 NGHRIQSSDDRRMTQYRDVHRLVFPAVGP---QHAGVYKSVIANKLGKAACYAHL 1275
Score = 64.7 bits (156), Expect = 6e-10
Identities = 64/257 (24%), Positives = 102/257 (39%), Gaps = 65/257 (25%)
Query: 1063 KEPLQERFFR---PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASH 1119
+EPL+ F + + APG V L C ++ PPP+++W +G + +
Sbjct: 716 EEPLEAPVFEIPLQNVVVAPGADVL-------LKCIITANPPPQVSWHKDGSALRSEG-- 766
Query: 1120 KMLVRETGV-HSLLIDPLTQRDAGTYKCIATN-------------KTGQNSFSLELSVVA 1165
++L+R G H+LL+ DAG+Y ATN + G ++ + +
Sbjct: 767 RLLLRAEGERHTLLLREARAADAGSYMATATNELGQATCAASLTVRPGGSTSPFSSPITS 826
Query: 1166 KEV------------------------------------KKAPVILEKLQNCGVPEGHPV 1189
E K P L + V EG V
Sbjct: 827 DEEYLSPPEEFPEPGETWPRTPTMKPSPSQNRRSSDTGSKAPPTFKVSLMDQSVREGQDV 886
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDAGWYTLSA 1248
+ RV G P PV W ++ + + + R + ++ G C L I A++ DAG+YT A
Sbjct: 887 IMSIRVQGEPKPVVSWLRNRQPVRPDQRRFA--EEAEGGLCRLRILAAERGDAGFYTCKA 944
Query: 1249 KNEAGIVSCTARLDIYA 1265
NE G C ARL++ A
Sbjct: 945 VNEYGARQCEARLEVRA 961
Score = 62.8 bits (151), Expect = 2e-09
Identities = 45/164 (27%), Positives = 77/164 (46%), Gaps = 26/164 (15%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP+FT++L+++ EG+ F+C++ G P P V W G +E+S + R+ Q
Sbjct: 1063 APLFTRLLEDVEVLEGRAARFDCKISGTPPPVVTWTHFGCPMEESENLRLRQ-------- 1114
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNL 553
+ +L IA V +ED G + +A N +G AQL+V ++ S
Sbjct: 1115 DGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQLYVEEPRTAASGPS---------- 1164
Query: 554 AAIEPQPSPPHSEPPSVEQPPKPKLEGVLV-NHNEPRSSSRIGL 596
+ +E PS P E+P + +LE + + + P +GL
Sbjct: 1165 SKLEKMPSIP-------EEPEQGELERLSIPDFLRPLQDLEVGL 1201
Score = 59.7 bits (143), Expect = 2e-08
Identities = 35/114 (30%), Positives = 53/114 (46%), Gaps = 4/114 (3%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP F+ ++ V G F + G P+P + W+KD +++ + + E + CS
Sbjct: 1484 APRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENE--CS 1541
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAG--QSHRGR 1055
L + ST + D G YT A N G +SC L V S + G + HRGR
Sbjct: 1542 LVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVGEDEDHRGR 1595
Score = 58.9 bits (141), Expect = 3e-08
Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 8/99 (8%)
Query: 434 APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
AP F +++++ G+ F V+G P P + WY++ L+ +S S
Sbjct: 1484 APRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHV--------SFVY 1535
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
E C+LV+ A+D G +TCTA N G VS A+L V
Sbjct: 1536 EENECSLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAV 1574
Score = 55.8 bits (133), Expect = 3e-07
Identities = 61/286 (21%), Positives = 111/286 (38%), Gaps = 32/286 (11%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P F + L+ EV L+C V G+P P + W+ G +++S D + Q ++H L
Sbjct: 1188 PDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVF 1247
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPP 388
+ G Y +N G + A +Y+ V +G P + + P
Sbjct: 1248 PAVGPQHAGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLTWNPPR 1307
Query: 389 TTSAVIPP----AVPQAQHLVAQPRVATIQQCQSP----TNYLQGLDG-KPIIAAPVFTK 439
+ I P Q Q L + A + + P T +G+ +++ V +
Sbjct: 1308 SLDMAIDPDSLTYTVQHQVLGSDQWTALVTGLREPGWAATGLRKGVQHIFRVLSTTVKSS 1367
Query: 440 MLQNLSASEGQLVVFECRVKGAPS----PKVEWYREG-----TLIEDSPDFRILQKKPR- 489
+ + QL+ ++ AP+ P + + EG T+ + + +++ + R
Sbjct: 1368 SKPSPPSEPVQLLEHGPTLEEAPAMLDKPDIVYVVEGQPASVTVTFNHVEAQVVWRSCRG 1427
Query: 490 ------------SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
S + ++ C L I V D G TCTA N++GT
Sbjct: 1428 ALLEARAGVYELSQPDDDQYC-LRICRVSRRDMGALTCTARNRHGT 1472
Score = 53.9 bits (128), Expect = 1e-06
Identities = 34/96 (35%), Positives = 43/96 (44%), Gaps = 9/96 (9%)
Query: 1168 VKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTG 1227
V APV L L+N V G VRL V G P P W +D + +P S
Sbjct: 39 VAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPS------- 91
Query: 1228 YACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
CL ++ DAG Y+ A+NE G SC A L +
Sbjct: 92 --CLWLRRCGAQDAGVYSCMAQNERGRASCEAVLTV 125
Score = 53.9 bits (128), Expect = 1e-06
Identities = 45/169 (26%), Positives = 66/169 (39%), Gaps = 32/169 (18%)
Query: 225 NHALEQQEAKRREAEQAASEAAG--GDTTPGSSPSSLYY--------------------E 262
N Q A AE SEA+ G + PG S S L + +
Sbjct: 2509 NQLAAQAGATTPSAESLGSEASATSGSSAPGESRSRLRWGFSRPRKDKGLSPPNLSASVQ 2568
Query: 263 EPLGQ---------PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
E LG PP F KL+ + + EG L C+ P P + W + K L + P
Sbjct: 2569 EELGHQYVRSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEP 2628
Query: 314 DIHIVQA-GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGV 361
+ IV L+I A + G Y C A+N+ G+ ++S + + V
Sbjct: 2629 SVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARV 2677
Score = 53.1 bits (126), Expect = 2e-06
Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 7/137 (5%)
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
+ L I +++RD G C A N+ G + S+ L E+ +AP +++ V G
Sbjct: 1447 YCLRICRVSRRDMGALTCTARNRHGTQTCSVTL-----ELAEAPRFESIMEDVEVGAGET 1501
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
R V G P P W KD + + ++++ L++ D G YT +A
Sbjct: 1502 ARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENE--CSLVVLSTGAQDGGVYTCTA 1559
Query: 1249 KNEAGIVSCTARLDIYA 1265
+N AG VSC A L +++
Sbjct: 1560 QNLAGEVSCKAELAVHS 1576
Score = 52.4 bits (124), Expect = 3e-06
Identities = 144/641 (22%), Positives = 217/641 (33%), Gaps = 135/641 (21%)
Query: 231 QEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQP------PRFTQKLRSREVPEGT 284
Q+A+ E A + A +PG P G P P F + L++ V G+
Sbjct: 2 QKARGTRGEDAGTRAP---PSPGVPPKRAKVGAGGGAPVAVAGAPVFLRPLKNAAVCAGS 58
Query: 285 RVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
V+L +V G P P +RW+ +G+ L A L + +D G YSC A
Sbjct: 59 DVRLRVVVSGTPQPSLRWFRDGQLLP-------APAPEPSCLWLRRCGAQDAGVYSCMAQ 111
Query: 345 NIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHL 404
N G S A + + V S++ D + V Q L
Sbjct: 112 NERGRASCEAVLTVLEVGDSETAEDDISD------------------------VQGTQRL 147
Query: 405 VAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSP 464
+ A +PT L G + P V G
Sbjct: 148 ELRDDGA----FSTPTGGSDTLVGTSLDTPPT--------------------SVTGTSEE 183
Query: 465 KVEWYREG-TLIEDSP----DFRILQKKPRSM----AEPEEI----------CTLVIAEV 505
+V W+ G T++E R L PR A P + LV A
Sbjct: 184 QVSWWGSGQTVLEQEAGSGGGTRRLPGSPRQAQATGAGPRHLGVEPLVRASRANLVGASW 243
Query: 506 FAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQ-----P 560
+EDS AS+ YG+ S+ RG LS + S+ + ++PQ P
Sbjct: 244 GSEDS---LSVASDLYGSAFSL----YRGRA-LSIHVSVPQSGLRREEPDLQPQLASEAP 295
Query: 561 SPPHSEPPS---VEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFN-----LPEDDKGSE-- 610
P PPS + PP P++ G P + H LPED E
Sbjct: 296 RRPAQPPPSKSALLPPPSPRV-GKRSPPGPPAQPAATPTSPHRRTQEPVLPEDTTTEEKR 354
Query: 611 ----ASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQLQQL 666
SS + T ++RP + +G+ + V+ +L K + + + L
Sbjct: 355 GKKSKSSGPSLAGTAESRPQTPLSEASGRLSALGRSPRLVRAGSRILDKLQFFEERRRSL 414
Query: 667 HNQVLLEQHQLQNPPPSSP-----KEFPFSMTVLNSNAPPAVT-TSSKQVKAPSSQTFSL 720
+ P P P K AP S ++++AP S
Sbjct: 415 -------ERSDSPPAPLRPWVPLRKARSLEQPKSERGAPWGTPGASQEELRAPGSVAERR 467
Query: 721 ARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSI 780
+ S + +P+S + I+R+ S+E L+ SH S++ ++
Sbjct: 468 RLFQQKAASLDERTRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRA------TL 521
Query: 781 QNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTS 821
Q P P EP PP FS PS + R VSP P S
Sbjct: 522 QR---APSPREPGEPPL-FSRPSTPK-TSRAVSPAAAQPPS 557
Score = 52.4 bits (124), Expect = 3e-06
Identities = 31/113 (27%), Positives = 49/113 (43%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L + PRF + EV G + +V G P P + WY + L S + V N
Sbjct: 1481 LAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKDEVLLTESSHVSFVYEENEC 1540
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNR 377
SL + +D G Y+C A N+ G S AE+ + ++ ++E +R
Sbjct: 1541 SLVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVGEDEDHR 1593
Score = 48.5 bits (114), Expect = 4e-05
Identities = 35/125 (28%), Positives = 53/125 (42%), Gaps = 9/125 (7%)
Query: 938 PTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRRE 997
P AP+F + LK+ V GS V + G P P + WF+DG+ +
Sbjct: 36 PVAVAGAPVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLP--------APA 87
Query: 998 GDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSR 1057
+ +C L + + D G Y+ MA N +GR SC L V + +G R
Sbjct: 88 PEPSC-LWLRRCGAQDAGVYSCMAQNERGRASCEAVLTVLEVGDSETAEDDISDVQGTQR 146
Query: 1058 VQERD 1062
++ RD
Sbjct: 147 LELRD 151
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 7/93 (7%)
Query: 441 LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTL 500
LQ++ G++ +FEC V G +V+W G L++ + +L+ K M C L
Sbjct: 974 LQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPA----LLKCK---MHFDGRKCKL 1026
Query: 501 VIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
++ V +DSG +TC S ++ A+L VR
Sbjct: 1027 LLTSVHEDDSGVYTCKLSTAKDELTCSARLTVR 1059
Score = 46.2 bits (108), Expect = 2e-04
Identities = 49/208 (23%), Positives = 72/208 (34%), Gaps = 34/208 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V EG P + T + V+ G + R ++ + D L I + D G
Sbjct: 1401 VVEGQPASVTVTFNHVEAQVVWRSCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMG 1460
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
T A N G +CS + L A P F
Sbjct: 1461 ALTCTARNRHGTQTCS---------VTLELAEA------------------------PRF 1487
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
D+ G R V G P P++ W + + +L ++SH V E SL++
Sbjct: 1488 ESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKD-EVLLTESSHVSFVYEENECSLVVLS 1546
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSV 1163
+D G Y C A N G+ S EL+V
Sbjct: 1547 TGAQDGGVYTCTAQNLAGEVSCKAELAV 1574
Score = 43.9 bits (102), Expect = 0.001
Identities = 31/105 (29%), Positives = 47/105 (44%)
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
E F P F D V EG L C + P P ++W+ + + + + S ++ + G
Sbjct: 2579 ESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDG 2638
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP 1172
L I +R AG Y+C ATN G + S ++V K AP
Sbjct: 2639 RQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAP 2683
Score = 42.7 bits (99), Expect = 0.002
Identities = 84/390 (21%), Positives = 134/390 (34%), Gaps = 79/390 (20%)
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
PVF L++ EG+ C P+P + W ++ + P I+ K
Sbjct: 2584 PVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEPSVIIVSCKDGRQ--- 2640
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLA 554
L I +G + C+A+N G+++S + V + T L
Sbjct: 2641 ----LLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPPEVPQTYQDTALV 2696
Query: 555 AIEPQPS--------PPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDD 606
+P S + SV P + N + +G+ V F + +
Sbjct: 2697 LWKPGDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYN----VTHLPVGVTVRFRVACAN 2752
Query: 607 KGSEA--SSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPP----PVLAKPKLDS 660
+ + S+ + V R T+ S PS+ +E P P A+P
Sbjct: 2753 RAGQGPFSNSSEKVFVRGTQDSS------------AVPSAAHQEAPVTSRPARARPPDSP 2800
Query: 661 TQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSN--APPAVTTSSKQVKAPSSQT- 717
T L PP + P S+TV S+ PP+ SS + P QT
Sbjct: 2801 TSLA---------------PPLAPAAPTPPSVTVSPSSPPTPPSQALSSLKAVGPPPQTP 2845
Query: 718 ------FSLARP-KYFFPSTNTTAATVAP----SSSPVFTLSSTPQTIQRTVSKESLLVS 766
ARP + PST+ T + P + +P+ +STPQ ++ S + V
Sbjct: 2846 PRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPI--PASTPQGVKPVSSSTPVYVV 2903
Query: 767 HPSVQTKSPGGLSIQNEPLPPGPTEPTPPP 796
S + P P P P PPP
Sbjct: 2904 -----------TSFVSAPPAPEPPAPEPPP 2922
Score = 42.0 bits (97), Expect = 0.004
Identities = 31/115 (26%), Positives = 43/115 (37%), Gaps = 9/115 (7%)
Query: 930 DEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRN 989
+E+ H + + P+F +LK + EG T C P P + W KD K +
Sbjct: 2569 EELGHQYVRSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLRSEP 2628
Query: 990 E----HCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
CK DG L I G Y A N G I+ S + V +P
Sbjct: 2629 SVIIVSCK-----DGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVP 2678
Score = 40.4 bits (93), Expect = 0.011
Identities = 31/100 (31%), Positives = 39/100 (39%), Gaps = 1/100 (1%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQA-GNLHSL 326
PP F L + V EG V + V G P P V W + + +A G L L
Sbjct: 868 PPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRL 927
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDS 366
I A D G Y+C A N YG A + + S S
Sbjct: 928 RILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRS 967
Score = 38.9 bits (89), Expect = 0.033
Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 12/94 (12%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQ--PVLPDASHKMLVRETGVHS 1130
P FL+ + G RL VSG P P L W +GQ P + +R G
Sbjct: 43 PVFLRPLKNAAVCAGSDVRLRVVVSGTPQPSLRWFRDGQLLPAPAPEPSCLWLRRCGA-- 100
Query: 1131 LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVV 1164
+DAG Y C+A N+ G+ S L+V+
Sbjct: 101 --------QDAGVYSCMAQNERGRASCEAVLTVL 126
Score = 35.8 bits (81), Expect = 0.28
Identities = 48/229 (20%), Positives = 83/229 (36%), Gaps = 29/229 (12%)
Query: 547 ANSTTNLAAIEPQPSPPHSEPPSVE--QPPKPKLEGVLVNHNEPRSSSR-IGLRVHFNLP 603
+ + ++L A+ P P P ++ +P +P L V +EP+ G + + P
Sbjct: 2829 SQALSSLKAVGPPPQTPPRRHRGLQAARPAEPTLPSTHVTPSEPKPFVLDTGTPIPASTP 2888
Query: 604 EDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDSTQL 663
+ K +S+ VVT+ + P P P P EPPP K + S
Sbjct: 2889 QGVKPVSSSTPVYVVTSFVSAP--------------PAPEPPAPEPPPEPTKVTVQS--- 2931
Query: 664 QQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSLARP 723
L ++ + P SSP+ P PP + + KA F + R
Sbjct: 2932 -------LSPAKEVVSSPGSSPRSSPRPEGTTLRQGPPQKPYTFLEEKARG--RFGVVRA 2982
Query: 724 KYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQT 772
+ T A + P ++ + RT+ E ++ H + T
Sbjct: 2983 CRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSLHEAYIT 3031
Score = 35.0 bits (79), Expect = 0.48
Identities = 30/97 (30%), Positives = 40/97 (41%), Gaps = 3/97 (3%)
Query: 1164 VAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQ 1223
V E PV KL++ + EG L C P P W KD +++ + + +
Sbjct: 2576 VRSESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMKDKKSLR-SEPSVIIVS 2634
Query: 1224 DTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV--SCT 1258
G L I A K AG Y SA N G + SCT
Sbjct: 2635 CKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCT 2671
Score = 32.7 bits (73), Expect = 2.4
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 5/87 (5%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENS---PDIHIVQAGNLHSLTIAEA 331
L+ +V G +C+V G +V W C G+ L+ + +H G L +
Sbjct: 974 LQDVDVGAGEMALFECLVAGPTDVEVDWLCRGRLLQPALLKCKMHF--DGRKCKLLLTSV 1031
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYI 358
E+D+G Y+C S + SA + +
Sbjct: 1032 HEDDSGVYTCKLSTAKDELTCSARLTV 1058
Score = 31.6 bits (70), Expect = 5.3
Identities = 30/131 (22%), Positives = 47/131 (35%), Gaps = 18/131 (13%)
Query: 740 SSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSIQNEPLPPGPTEPTPPPFTF 799
SS VF + + + + + V+ + + P + PL P PTPP T
Sbjct: 2762 SSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPL--APAAPTPPSVTV 2819
Query: 800 SIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAIPPTNAMGLPRSAPSMPSQG 859
S P SP + ++ L +V P P PP GL + P+ P+
Sbjct: 2820 S---------------PSSPPTPPSQALSSLKAVGPP-PQTPPRRHRGLQAARPAEPTLP 2863
Query: 860 LAKKNTKSPQP 870
P+P
Sbjct: 2864 STHVTPSEPKP 2874
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 109 bits (272), Expect = 2e-23
Identities = 80/313 (25%), Positives = 130/313 (41%), Gaps = 52/313 (16%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P+ LK + + P+T +C+ G+P P + W KDG+ I + +R+ +
Sbjct: 4077 VPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVE-----SIRQRVLSSG 4131
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
SL I D G+YT MAAN G S S L V +P R R T
Sbjct: 4132 SLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVH-VPPRIRSTE--------------- 4175
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
G +E L C G+P P + W + +L + K
Sbjct: 4176 -----------------GHYTVNENSQAILPCVADGIPTPAINWKKDNV-LLANLLGKYT 4217
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
G L+++ + D+G Y C+A N G+++ ++ L+V P E +
Sbjct: 4218 AEPYG--ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHV-----LPTFTELPGDVS 4270
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
+ +G +RL C+ G+P P W +N IP + ++ H + L+I+ K D+G
Sbjct: 4271 LNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSE------LVIERVSKEDSG 4324
Query: 1243 WYTLSAKNEAGIV 1255
Y +A+N G V
Sbjct: 4325 TYVCTAENSVGFV 4337
Score = 103 bits (257), Expect = 1e-21
Identities = 86/311 (27%), Positives = 126/311 (40%), Gaps = 44/311 (14%)
Query: 957 TEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGN 1016
T +PVT TC GIP P + W K+ K+I N R G L I + D GN
Sbjct: 3164 TISNPVTLTCDATGIPPPTIAWLKNHKRIE--NSDSLEVRILSGGSKLQIARSQHSDSGN 3221
Query: 1017 YTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFL 1076
YT +A+N +G+ L +Q P + AG
Sbjct: 3222 YTCIASNMEGKAQKYYFLSIQVPP-----SVAGA-------------------------- 3250
Query: 1077 QAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPL 1136
+ P D+ G L C +G+P P + WL +G+P+ + ++ V G + L
Sbjct: 3251 EIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGAL 3310
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
T D G Y C+ATN G+ L+V V ++ EKL + +ECR
Sbjct: 3311 TS-DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTL---VDTSINIECRA 3366
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMH-QDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G PPP W K+ +P +S H + + I A+ SD YT A N AG+
Sbjct: 3367 TGTPPPQINWLKNGLPLP-----LSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV 3421
Query: 1255 VSCTARLDIYA 1265
+ L ++A
Sbjct: 3422 DNKHYNLQVFA 3432
Score = 103 bits (256), Expect = 1e-21
Identities = 93/328 (28%), Positives = 131/328 (39%), Gaps = 59/328 (17%)
Query: 953 HFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSD 1012
H+ V E S C GIP P + W KD ++ N K E G L +E+ +
Sbjct: 4177 HYTVNENSQAILPCVADGIPTPAINWKKDNVLLA--NLLGKYTAEPYG--ELILENVVLE 4232
Query: 1013 DDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFR 1072
D G YT +A N G + + L V LP
Sbjct: 4233 DSGFYTCVANNAAGEDTHTVSLTVHVLPT------------------------------- 4261
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
F + PGD+ ++G RL CK +G+P P+LTW N ++P + G L+
Sbjct: 4262 --FTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN-IIPAHFDSV----NGHSELV 4314
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL-EKLQNCGVPEGHPVRL 1191
I+ +++ D+GTY C T +NS ++ VK+ PV + N P G L
Sbjct: 4315 IERVSKEDSGTYVC-----TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAIL 4369
Query: 1192 ECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
C V G P P W + I IS G L I DAG YT A NE
Sbjct: 4370 NCEVKGDPTPTIQWNRKGVDI-----EISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 1252 AGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
AG+V + L + Q PP +++ P
Sbjct: 4425 AGVVERSMSLTL------QSPPIITLEP 4446
Score = 101 bits (251), Expect = 5e-21
Identities = 83/311 (26%), Positives = 125/311 (40%), Gaps = 50/311 (16%)
Query: 954 FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDD 1013
F VT+ +P TC G+P P ++W K+G ++ R + ++ G ++ I +T +
Sbjct: 3906 FLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSG----AIEILATQLNH 3961
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G YT +A N +AG +HR V EP P
Sbjct: 3962 AGRYTCVARN-----------------------AAGSAHR---HVTLHVHEP-------P 3988
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
P ++ L C+ +G P P +TW G V + ++ G L I
Sbjct: 3989 VIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG---LQI 4045
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ DAGTY C+A N G ++L+V + PVI L+ + P+ L C
Sbjct: 4046 SRAVREDAGTYMCVAQNPAGTALGKIKLNV-----QVPPVISPHLKEYVIAVDKPITLSC 4100
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
G+PPP W KD I S+ Q L I + DAG YT A N AG
Sbjct: 4101 EADGLPPPDITWHKDGRAIV-----ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Query: 1254 IVSCTARLDIY 1264
S + +L ++
Sbjct: 4156 SSSTSTKLTVH 4166
Score = 100 bits (248), Expect = 1e-20
Identities = 91/328 (27%), Positives = 135/328 (41%), Gaps = 59/328 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +P+ TC GIP PK+ W KDG+ + + ++ ++ G G L I + +D G
Sbjct: 3540 VIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQ---VQTLGGGEV-LRISTAQVEDTG 3595
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT +A++P G + DKE L P+
Sbjct: 3596 RYTCLASSPAG---------------------------------DDDKEYLVRVHVPPNI 3622
Query: 1076 L--QAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
P D+ R L+CK +PPP +TWL NG+ + ++L +G L I
Sbjct: 3623 AGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRIL---SGGRYLQI 3679
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ D Y C+A+N G+ + L+V V +K P L L N LE
Sbjct: 3680 NNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLN------KSTVLE 3733
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C G+P P W+KD + R S+ ++ L IQ A +D G Y A N A
Sbjct: 3734 CIAEGVPTPRITWRKDGAVLAGNHARYSILEN----GFLHIQSAHVTDTGRYLCMATNAA 3789
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
G T R I Q H +PP ++ P+
Sbjct: 3790 G----TDRRRIDLQVH--VPPSIAPGPT 3811
Score = 99.0 bits (245), Expect = 3e-20
Identities = 90/297 (30%), Positives = 121/297 (40%), Gaps = 43/297 (14%)
Query: 958 EGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNY 1017
EG PVT CK G P P V W K G+ IS K DG SL++ S ++ G Y
Sbjct: 994 EGIPVTLPCKASGNPKPSVIWSKKGELIS--TSSAKFSAGADG--SLYVVSPGGEESGEY 1049
Query: 1018 TIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
A N G L V +R R+ G R +DK
Sbjct: 1050 VCTATNTAGYAKRKVQLTVY---VRPRVF-------GDQRGLSQDK-------------- 1085
Query: 1078 APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLT 1137
P ++ G L C+V LPPP +TW Q + P + + S+ I
Sbjct: 1086 -PVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPS---GSMKITETR 1141
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
D+G Y C+ATN G + +++L+V V ++++ P L+ V G V + C
Sbjct: 1142 TSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLK------VQVGQRVDIPCNAQ 1195
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
G P PV W K T+ E + D T L I A SDAG YT A N AG
Sbjct: 1196 GTPLPVITWSKGGSTMLVDGEHHVSNPDGT----LSIDQATPSDAGIYTCVATNIAG 1248
Score = 94.7 bits (234), Expect = 5e-19
Identities = 80/299 (26%), Positives = 127/299 (42%), Gaps = 44/299 (14%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G V C GIP P + W KDGK I+ E ++R +G+ +L+I + D G YT
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIAS-GETERIRVSANGS-TLNIYGALTSDTGKYT 3318
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A NP G +L V P + RG E+
Sbjct: 3319 CVATNPAGEEDRIFNLNVYVTP----------TIRGNKDEAEK----------------- 3351
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
++ ++C+ +G PPP++ WL NG P LP +SH L+ V ++ ++
Sbjct: 3352 ---LMTLVDTSINIECRATGTPPPQINWLKNGLP-LPLSSHIRLLAAGQVIRIVRAQVS- 3406
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
D Y C+A+N+ G ++ L V A + E++ V +G + C G
Sbjct: 3407 -DVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEIT---VLKGSSTSMACITDGT 3462
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLL-IQPAKKSDAGWYTLSAKNEAGIVS 1256
P P W +D + + + H + + +L + A+ D+G YT A NEAG VS
Sbjct: 3463 PAPSMAWLRDGQPL-----GLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVS 3516
Score = 93.6 bits (231), Expect = 1e-18
Identities = 83/307 (27%), Positives = 125/307 (40%), Gaps = 49/307 (15%)
Query: 951 LKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTT 1010
L V EG+ ++ C+ GIP P + W K G + + R G L I
Sbjct: 2203 LTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVL--TDSMGRVRILSGGRQLQISIAE 2260
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D Y+ +A+N G +L V IR +T++G SH
Sbjct: 2261 KSDAALYSCVASNVAGTAKKEYNLQVY---IRPTITNSG-SH------------------ 2298
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS 1130
P +++ G+ L+C+V G+PPP +TW+ +G P++ ++L + G H
Sbjct: 2299 --------PTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEIL--DEG-HI 2347
Query: 1131 LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL---EKLQNCGVPEGH 1187
L + + D G Y C+A N G +LSV A P I+ +N V E +
Sbjct: 2348 LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA-----PPSIIGNHRSPENISVVEKN 2402
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRE-RISMHQDTTGYACLLIQPAKKSDAGWYTL 1246
V L C G+P P W KD + + RI +G L + DAG YT
Sbjct: 2403 SVSLTCEASGIPLPSITWFKDGWPVSLSNSVRI-----LSGGRMLRLMQTTMEDAGQYTC 2457
Query: 1247 SAKNEAG 1253
+N AG
Sbjct: 2458 VVRNAAG 2464
Score = 93.6 bits (231), Expect = 1e-18
Identities = 83/309 (26%), Positives = 123/309 (39%), Gaps = 44/309 (14%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
VT G ++ C++ GIP P V W KDG + K + ++ EG L +++ D G
Sbjct: 2304 VTRGKSISLECEVQGIPPPTVTWMKDGHPLIKA-KGVEILDEGH---ILQLKNIHVSDTG 2359
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y +A N G L V + P S +HR + +K +
Sbjct: 2360 RYVCVAVNVAGMTDKKYDLSVHAPP------SIIGNHRSPENISVVEKNSVS-------- 2405
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L C+ SG+P P +TW +G PV S ++L +G L +
Sbjct: 2406 ----------------LTCEASGIPLPSITWFKDGWPVSLSNSVRIL---SGGRMLRLMQ 2446
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
T DAG Y C+ N G+ LSV+ V V L++ V E V L C V
Sbjct: 2447 TTMEDAGQYTCVVRNAAGEERKIFGLSVL---VPPHIVGENTLEDVKVKEKQSVTLTCEV 2503
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G P P W KD + + + H +G L I + G YT A + AG
Sbjct: 2504 TGNPVPEITWHKDGQPL----QEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHK 2559
Query: 1256 SCTARLDIY 1264
S + L+++
Sbjct: 2560 SRSFSLNVF 2568
Score = 93.2 bits (230), Expect = 1e-18
Identities = 80/320 (25%), Positives = 123/320 (38%), Gaps = 50/320 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+ + V +P+ C+ G P P + W K+G ++ + + G L
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSG----GL 4043
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I +D G Y +A NP G L VQ P+ S
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVIS--------------------- 4082
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
PH + V + L C+ GLPPP++TW +G+ ++ ++L
Sbjct: 4083 --------PHLKE----YVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVL-- 4128
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP 1184
SL I + DAG Y C+A N G +S S +L+V P I + V
Sbjct: 4129 --SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVP-----PRIRSTEGHYTVN 4181
Query: 1185 EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
E L C G+P P WKKDN + + + Y L+++ D+G+Y
Sbjct: 4182 ENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEP----YGELILENVVLEDSGFY 4237
Query: 1245 TLSAKNEAGIVSCTARLDIY 1264
T A N AG + T L ++
Sbjct: 4238 TCVANNAAGEDTHTVSLTVH 4257
Score = 92.4 bits (228), Expect = 3e-18
Identities = 84/298 (28%), Positives = 113/298 (37%), Gaps = 45/298 (15%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V + PV C GIP P + W KD + ++ + K++ G L I T +D G
Sbjct: 1838 VVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGR---VLQIAKTLLEDAG 1894
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT +A N G L V P L AG+ V P+Q
Sbjct: 1895 RYTCVATNAAGETQQHIQLHVHEPP---SLEDAGKMLNETVLVSN----PVQ-------- 1939
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L+CK +G P P +TW + + + S L R + I+
Sbjct: 1940 ----------------LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIID---IES 1980
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
DAG YKC+A N G L +V AP I V +PVRLEC
Sbjct: 1981 AQISDAGIYKCVAINSAGATELFYSL-----QVHVAPSISGSNNMVAVVVNNPVRLECEA 2035
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
G+P P W KD + + Q +G L + A+ SD G YT A N AG
Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGL---QVLSGGRILALTSAQISDTGRYTCVAVNAAG 2090
Score = 92.0 bits (227), Expect = 3e-18
Identities = 87/315 (27%), Positives = 128/315 (40%), Gaps = 51/315 (16%)
Query: 953 HFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSD 1012
+F V + + C + G P P + W KDG+ I +R+ K+ G L I
Sbjct: 1743 YFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGF-KILLNGR---KLVIAQAQVS 1798
Query: 1013 DDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFR 1072
+ G Y MAAN G + V P + S+G S R
Sbjct: 1799 NTGLYRCMAANTAGDHKKEFEVTVHVPPT---IKSSGLSER------------------- 1836
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
V + + L C +G+P P +TWL + QPV A + ++ +G L
Sbjct: 1837 ----------VVVKYKPVALQCIANGIPNPSITWLKDDQPV-NTAQGNLKIQSSG-RVLQ 1884
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILE---KLQNCGVPEGHPV 1189
I DAG Y C+ATN G+ ++L V P LE K+ N V +PV
Sbjct: 1885 IAKTLLEDAGRYTCVATNAAGETQQHIQLHV------HEPPSLEDAGKMLNETVLVSNPV 1938
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+LEC+ G P PV W KDN + + +++ + I+ A+ SDAG Y A
Sbjct: 1939 QLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRG----QIIDIESAQISDAGIYKCVAI 1994
Query: 1250 NEAGIVSCTARLDIY 1264
N AG L ++
Sbjct: 1995 NSAGATELFYSLQVH 2009
Score = 92.0 bits (227), Expect = 3e-18
Identities = 79/323 (24%), Positives = 125/323 (38%), Gaps = 46/323 (14%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+AP V +PV C+ GIP P + W KDG +S + ++ G
Sbjct: 2010 VAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR--- 2066
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L + S D G YT +A N G E+
Sbjct: 2067 ILALTSAQISDTGRYTCVAVNAAG---------------------------------EKQ 2093
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
++ + P+ + ++ + L C+ +PPP LTWL +G P+L +
Sbjct: 2094 RDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSIS 2153
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNC 1181
+ L I+ +D G Y C ATN G+ + +++ V + + ++L
Sbjct: 2154 ENRS---VLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGS----DELTQL 2206
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V EG+ + L C G+PPP WKK P + + + +G L I A+KSDA
Sbjct: 2207 TVIEGNLISLLCESSGIPPPNLIWKKKGS--PVLTDSMGRVRILSGGRQLQISIAEKSDA 2264
Query: 1242 GWYTLSAKNEAGIVSCTARLDIY 1264
Y+ A N AG L +Y
Sbjct: 2265 ALYSCVASNVAGTAKKEYNLQVY 2287
Score = 91.7 bits (226), Expect = 4e-18
Identities = 79/299 (26%), Positives = 116/299 (38%), Gaps = 50/299 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +PV CK G PVP + W+KD + +S + R + IES D G
Sbjct: 1932 VLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQ----IIDIESAQISDAG 1987
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y +A N G L V P
Sbjct: 1988 IYKCVAINSAGATELFYSLQVHVAPS---------------------------------- 2013
Query: 1076 LQAPGDMVAHE-GRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
+ +MVA RL+C+ G+P P LTWL +G PV ++ ++ +G L +
Sbjct: 2014 ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVL--SGGRILALT 2071
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECR 1194
D G Y C+A N G+ ++L V P I+ + QN V V L C+
Sbjct: 2072 SAQISDTGRYTCVAVNAAGEKQRDIDLRVYV-----PPNIMGEEQNVSVLISQAVELLCQ 2126
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+PPP W KD + + +S+ ++ + L I+ A+ D G YT A N AG
Sbjct: 2127 SDAIPPPTLTWLKDGHPL-LKKPGLSISENR---SVLKIEDAQVQDTGRYTCEATNVAG 2181
Score = 89.7 bits (221), Expect = 2e-17
Identities = 79/294 (26%), Positives = 118/294 (40%), Gaps = 44/294 (14%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
S + C+ G+P+P + W+KDG+ I ++ + D LHI D YT
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQALYI----DKGQYLHIPRAQVSDSATYTC 1618
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
AN G S H+ V P+ ++ PL ++ H L
Sbjct: 1619 HVANVAGTAEKSFHVDVYVPPM----------------IEGNLATPLNKQVVIAHSLT-- 1660
Query: 1080 GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
L+CK +G P P LTWL +G PV + + ++ E G L I +
Sbjct: 1661 ------------LECKAAGNPSPILTWLKDGVPVKANDNIRI---EAGGKKLEIMSAQEI 1705
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMP 1199
D G Y C+AT+ G+ E+ V+ + ++ V + + L+C V G P
Sbjct: 1706 DRGQYICVATSVAGEKEIKYEVDVLVPPAIEGG---DETSYFIVMVNNLLELDCHVTGSP 1762
Query: 1200 PPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
PP W KD + I ER G L+I A+ S+ G Y A N AG
Sbjct: 1763 PPTIMWLKDGQLID---ERDGFKILLNGRK-LVIAQAQVSNTGLYRCMAANTAG 1812
Score = 89.0 bits (219), Expect = 3e-17
Identities = 87/321 (27%), Positives = 117/321 (36%), Gaps = 41/321 (12%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P + KH +V G V C G P+P + W K G + EH +G
Sbjct: 1169 VPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---- 1224
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
+L I+ T D G YT +A N G L VQ P D
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPT------------------VED 1266
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
EP F+ + VA++ C G P P + WL NG+ L +
Sbjct: 1267 LEPPYNTTFQ--------ERVANQR--IEFPCPAKGTPKPTIKWLHNGRE-LTGREPGIS 1315
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
+ E G L+I +T D G Y C+A N+ G L V V K E++ N
Sbjct: 1316 ILEDGT-LLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDK---EQVTNVS 1371
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
V L C V G P P+ W KDN + S Q L + A DAG
Sbjct: 1372 VLLNQLTNLFCEVEGTPSPIIMWYKDNVQV----TESSTIQTVNNGKILKLFRATPEDAG 1427
Query: 1243 WYTLSAKNEAGIVSCTARLDI 1263
Y+ A N AG +D+
Sbjct: 1428 RYSCKAINIAGTSQKYFNIDV 1448
Score = 88.2 bits (217), Expect = 5e-17
Identities = 85/325 (26%), Positives = 125/325 (38%), Gaps = 54/325 (16%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
+P++ C+ P P + W+KDG ++ ++ + G L I +D G YT
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLIL----PGGRVLQIPRAKVEDAGRYTC 2848
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
+A N G S + V PI S P
Sbjct: 2849 VAVNEAGEDSLQYDVRVLVPPIIKGANS-----------------------------DLP 2879
Query: 1080 GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
++ + ++C SG P P +W +GQP+L D HK L + +L +T
Sbjct: 2880 EEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFL-SNGRILQILNTQIT-- 2936
Query: 1140 DAGTYKCIATNKTG--QNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIG 1197
D G Y C+A N G + F+L + V VI K +N V + + L C V G
Sbjct: 2937 DIGRYVCVAENTAGSAKKYFNLNVHV------PPSVIGPKSENLTVVVNNFISLTCEVSG 2990
Query: 1198 MPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSC 1257
PPP W K+ + I + + G L I AK SD G YT A N+AG
Sbjct: 2991 FPPPDLSWLKNEQPIKLNTNTLIV----PGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 1258 TARLDIYAQWHHQIPPPMSVRPSGS 1282
L +Y +PP + S S
Sbjct: 3047 KFSLTVY------VPPSIKDHDSES 3065
Score = 88.2 bits (217), Expect = 5e-17
Identities = 77/326 (23%), Positives = 130/326 (39%), Gaps = 54/326 (16%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F + + +G + +CK GIP+PK+ W + I + +G
Sbjct: 4258 VLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSV------NGHS 4311
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L IE + +D G Y A N G + G + V+ P+
Sbjct: 4312 ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPV--------------------- 4350
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F+ + P + + G L+C+V G P P + W G + + SH+
Sbjct: 4351 --------FKGDY---PSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDI--EISHR-- 4395
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG 1182
+R+ G SL I DAG Y C+ATN+ G S+ L++ + P+I +
Sbjct: 4396 IRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTL-----QSPPIITLEPVETV 4450
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
+ G + L C+ G P P W + +I +R+++ + + L I A+K D
Sbjct: 4451 INAGGKIILNCQATGEPQPTITWSRQGHSISWD-DRVNVLSNNS----LYIADAQKEDTS 4505
Query: 1243 WYTLSAKNEAGIVSCTARLDIYAQWH 1268
+ A+N G S R+ + Q H
Sbjct: 4506 EFECVARNLMG--SVLVRVPVIVQVH 4529
Score = 87.0 bits (214), Expect = 1e-16
Identities = 90/368 (24%), Positives = 147/368 (39%), Gaps = 62/368 (16%)
Query: 926 DESDDEIQHDEIPTGKCIAPIFDK--------RLKHFRVTEGSPVTFTCKIVGIPVPKVY 977
+E+ + I+H E+ I PI +K K ++ + +T C+ IP +
Sbjct: 2650 NEAGEMIKHYEVKV--YIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLS 2707
Query: 978 WFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQ 1037
W+KDG+ + K ++H + G +L I+ D G YT +A+N G + +Q
Sbjct: 2708 WYKDGQPL-KSDDHVNIAANGH---TLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQ 2763
Query: 1038 SLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVS 1097
P +L G + +D + P L C+ +
Sbjct: 2764 VPPSFQKLWEIGNMLDTGRNGEAKDV-----------IINNP----------ISLYCETN 2802
Query: 1098 GLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSF 1157
PPP LTW +G P+ +S K+L+ G L I DAG Y C+A N+ G++S
Sbjct: 2803 AAPPPTLTWYKDGHPL--TSSDKVLILPGG-RVLQIPRAKVEDAGRYTCVAVNEAGEDSL 2859
Query: 1158 SLELSVVAKEVKKAPVILEKLQNCGVPE------GHPVRLECRVIGMPPPVFYWKKDNET 1211
++ V+ P+I K N +PE +EC G P P W+KD +
Sbjct: 2860 QYDVRVLV-----PPII--KGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ- 2911
Query: 1212 IPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQI 1271
P + H+ + L I + +D G Y A+N AG L+++
Sbjct: 2912 -PLLED--DHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV------ 2962
Query: 1272 PPPMSVRP 1279
PP + P
Sbjct: 2963 -PPSVIGP 2969
Score = 86.3 bits (212), Expect = 2e-16
Identities = 85/341 (24%), Positives = 134/341 (39%), Gaps = 55/341 (16%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIV-GIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+AP+ V EG +T C ++ G P+P+ W K+ + + N + +R +G
Sbjct: 888 VAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ-NPYITVRSDG--- 943
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER 1061
SLHIE D G YT +A+N G + + ++V LP GQ
Sbjct: 944 -SLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQH----GQQI--------- 989
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
+ EG L CK SG P P + W G+ ++ +S K
Sbjct: 990 --------------------LSTIEGIPVTLPCKASGNPKPSVIWSKKGE-LISTSSAKF 1028
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV---KKAPVILEKL 1178
G SL + ++G Y C ATN G ++L+V + + + +K
Sbjct: 1029 SAGADG--SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKP 1086
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
V G V L C V +PPP+ W K+ + I S + I +
Sbjct: 1087 VEISVLAGEEVTLPCEVKSLPPPIITWAKETQLI----SPFSPRHTFLPSGSMKITETRT 1142
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
SD+G Y A N AG V+ +L+++ +PP + P
Sbjct: 1143 SDSGMYLCVATNIAGNVTQAVKLNVH------VPPKIQRGP 1177
Score = 86.3 bits (212), Expect = 2e-16
Identities = 82/315 (26%), Positives = 126/315 (40%), Gaps = 54/315 (17%)
Query: 948 DKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIE 1007
+ L+ +V E VT TC++ G PVP++ W KDG+ + + H + G L I
Sbjct: 2483 ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII----SGGRFLQIT 2538
Query: 1008 STTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQ 1067
+ G YT +A++P G S S L V P T AG G
Sbjct: 2539 NVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSP-----TIAGVGSDGN------------ 2581
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P D+ L C+ PP +TW +G P+ + + ++L G
Sbjct: 2582 -----------PEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRIL---PG 2627
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG----- 1182
+L I + +AG Y C+ATN+ G+ E+ V P I+ K G
Sbjct: 2628 GRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVY------IPPIINKGDLWGPGLSP 2681
Query: 1183 ----VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
+ + + LEC +P W KD + + + ++ G+ L I+ A+
Sbjct: 2682 KEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPL---KSDDHVNIAANGHT-LQIKEAQI 2737
Query: 1239 SDAGWYTLSAKNEAG 1253
SD G YT A N AG
Sbjct: 2738 SDTGRYTCVASNIAG 2752
Score = 83.2 bits (204), Expect = 2e-15
Identities = 81/332 (24%), Positives = 130/332 (39%), Gaps = 56/332 (16%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
K+ T GS V+ C G P PK+ W + I + + R DGT L I++
Sbjct: 619 KNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRY---RMTSDGT--LFIKNAAP 673
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071
D G Y +A+N G DK+ R+
Sbjct: 674 KDAGIYGCLASNSAGT----------------------------------DKQNSTLRYI 699
Query: 1072 R-PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS 1130
P + +++ G + ++CK SG+PPP++ W + P L+ + +
Sbjct: 700 EAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPST---FLIIDPLLGL 756
Query: 1131 LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVR 1190
L I DAG Y C+A N+ G+ + + L +V PV +++ + + G V
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKITL-----DVGSPPVFIQEPADVSMEIGSNVT 811
Query: 1191 LECRVIGMPPPVFYWKK-DNETIPCTRERI-SMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
L C V G P P W++ DN I + S+ Q TG L I SD G Y A
Sbjct: 812 LPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG--ALFILNLWASDKGTYICEA 869
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
+N+ G + + + + P + + PS
Sbjct: 870 ENQFGKIQSETTVTVTG----LVAPLIGISPS 897
Score = 83.2 bits (204), Expect = 2e-15
Identities = 81/334 (24%), Positives = 132/334 (39%), Gaps = 54/334 (16%)
Query: 946 IFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLH 1005
+ + ++ V + ++ TC++ G P P + W K+ + I + G +L
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIV----PGGRTLQ 3021
Query: 1006 IESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEP 1065
I D G YT +A N G L V P +++ D E
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPP----------------SIKDHDSES 3065
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRE 1125
L R EG L+C+ + +PPP +TW NG+ + ++L
Sbjct: 3066 LSVVNVR-------------EGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG 3112
Query: 1126 TGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAP---VILEKLQNCG 1182
+H I D G Y C A N G++ + L+V + P VI+E + N
Sbjct: 3113 QMLH---IKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISN-- 3167
Query: 1183 VPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAG 1242
PV L C G+PPP W K+++ I + + + + +G + L I ++ SD+G
Sbjct: 3168 -----PVTLTCDATGIPPPTIAWLKNHKRIE-NSDSLEV-RILSGGSKLQIARSQHSDSG 3220
Query: 1243 WYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
YT A N G L I Q+PP ++
Sbjct: 3221 NYTCIASNMEGKAQKYYFLSI------QVPPSVA 3248
Score = 82.4 bits (202), Expect = 3e-15
Identities = 74/302 (24%), Positives = 120/302 (39%), Gaps = 43/302 (14%)
Query: 962 VTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMA 1021
V C++ G P P ++WFKDGK + + + ++ G LH+++ +D G Y
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQ---VLHLKNARRNDKGRYQCTV 1527
Query: 1022 ANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGD 1081
+N G+ + L + P S +G + D
Sbjct: 1528 SNAAGKQAKDIKLTIYIPP----------SIKGGN---------------------VTTD 1556
Query: 1082 MVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDA 1141
+ L +L+C+ GLP P +TW +GQP++ +S + L + G + L I D+
Sbjct: 1557 ISVLINSLIKLECETRGLPMPAITWYKDGQPIM--SSSQALYIDKGQY-LHIPRAQVSDS 1613
Query: 1142 GTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPP 1201
TY C N G S + V + + L N V H + LEC+ G P P
Sbjct: 1614 ATYTCHVANVAGTAEKSFHVDVYVPPMIEGN--LATPLNKQVVIAHSLTLECKAAGNPSP 1671
Query: 1202 VFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARL 1261
+ W KD + + I + G L I A++ D G Y A + AG +
Sbjct: 1672 ILTWLKDGVPVK-ANDNIRIE---AGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV 1727
Query: 1262 DI 1263
D+
Sbjct: 1728 DV 1729
Score = 81.6 bits (200), Expect = 4e-15
Identities = 75/308 (24%), Positives = 116/308 (37%), Gaps = 57/308 (18%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQI-SKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
SP + C+ P + WFKDG + S RN R G +L I + D+ G Y+
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNI-----RILPGGRTLQILNAQEDNAGRYS 2645
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N G + + V PI ++ G +
Sbjct: 2646 CVATNEAGEMIKHYEVKVYIPPIINKGDLWGPG-------------------------LS 2680
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
P ++ L+C+ +P L+W +GQP+ D + H+L I
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANG---HTLQIKEAQI 2737
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG-------------VPE 1185
D G Y C+A+N G++ ++++ + P +KL G V
Sbjct: 2738 SDTGRYTCVASNIAGEDELDFDVNI------QVPPSFQKLWEIGNMLDTGRNGEAKDVII 2791
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
+P+ L C PPP W KD + + + + + G L I AK DAG YT
Sbjct: 2792 NNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLIL----PGGRVLQIPRAKVEDAGRYT 2847
Query: 1246 LSAKNEAG 1253
A NEAG
Sbjct: 2848 CVAVNEAG 2855
Score = 80.9 bits (198), Expect = 8e-15
Identities = 82/356 (23%), Positives = 130/356 (36%), Gaps = 59/356 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G VT C++ +P P + W K+ + IS + G S+ I T + D G
Sbjct: 1091 VLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSG----SMKITETRTSDSG 1146
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y +A N G ++ + L V P ++Q
Sbjct: 1147 MYLCVATNIAGNVTQAVKLNVHVPP----------------KIQ---------------- 1174
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
+ P + G+ + C G P P +TW G +L D H + + +L ID
Sbjct: 1175 -RGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG---TLSIDQ 1230
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQNCGVPE---GHPVR 1190
T DAG Y C+ATN G + + L V++ P + LE N E +
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITL-----HVQEPPTVEDLEPPYNTTFQERVANQRIE 1285
Query: 1191 LECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
C G P P W + + IS+ +D T L+I D G Y A N
Sbjct: 1286 FPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGT---LLVIASVTPYDNGEYICVAVN 1342
Query: 1251 EAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMV 1306
EAG L ++ +PP + + + L ++ ++F S ++
Sbjct: 1343 EAGTTERKYNLKVH------VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPII 1392
Score = 80.1 bits (196), Expect = 1e-14
Identities = 89/355 (25%), Positives = 151/355 (42%), Gaps = 39/355 (10%)
Query: 201 DLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLY 260
+L+ +R V + PA R N +LE + K +A + + + GSS +S++
Sbjct: 550 NLTWQRNDRDVRLAEPARIR-TLANLSLELKSVKFNDAGEYHCMVS---SEGGSSAASVF 605
Query: 261 YEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQA 320
+ +PP+ T +++ G+ V + C G P P++ W + S +
Sbjct: 606 LT--VQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD 663
Query: 321 GNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI-YIEG----VSSSD---SEGDPNK 372
G +L I A +D G Y C ASN GTD ++ + YIE V S+ + GD
Sbjct: 664 G---TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITV 720
Query: 373 EEMNRIQKP--------NEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
E P ++ P+T +I P + + Q A C + N
Sbjct: 721 MECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVA-INEAG 779
Query: 425 GLDGK---PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDF 481
GK + + PVF + ++S G V C V+G P P ++W R +++ P F
Sbjct: 780 RATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRR----LDNMPIF 835
Query: 482 RILQKKPRSMAEPEEICT--LVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+P S++ ++ T L I ++A D G + C A N++G + S + V G
Sbjct: 836 ----SRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886
Score = 79.7 bits (195), Expect = 2e-14
Identities = 68/284 (23%), Positives = 112/284 (39%), Gaps = 33/284 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP + L+ + + L C G+PPP + W+ +G+ + S ++ +G SL
Sbjct: 4078 PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSG---SLQ 4134
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDS-EGDPNKEEMNRIQKPNEVSS 386
IA D G Y+C A+N+ G+ STS ++ + S EG E ++ P
Sbjct: 4135 IAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADG 4194
Query: 387 PPTTSAVIPP-------------AVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA 433
PT + A P + ++ + N G D +
Sbjct: 4195 IPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSL 4254
Query: 434 A----PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
P FT++ ++S ++G+ + C+ G P PK+ W +I P
Sbjct: 4255 TVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNII------------PA 4302
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
LVI V EDSG + CTA N G V +I ++V+
Sbjct: 4303 HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVK 4346
Score = 78.6 bits (192), Expect = 4e-14
Identities = 76/299 (25%), Positives = 116/299 (38%), Gaps = 47/299 (15%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +GS + C G P P + W +DG+ + + H + G L + ++D G
Sbjct: 3447 VLKGSSTSMACITDGTPAPSMAWLRDGQPLG-LDAHLTVSTHG---MVLQLLKAETEDSG 3502
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT +A+N G +S L V P + + H S + E
Sbjct: 3503 KYTCIASNEAGEVSKHFILKVLEPP----HINGSEEHEEISVIVNNPLE----------- 3547
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
L C SG+P P++TW+ +G+P LP + G L I
Sbjct: 3548 ----------------LTCIASGIPAPKMTWMKDGRP-LPQTDQVQTL--GGGEVLRIST 3588
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
D G Y C+A++ G + + +V V ++ ++ V V LEC+
Sbjct: 3589 AQVEDTGRYTCLASSPAGDDD---KEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKS 3645
Query: 1196 IGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+PPPV W ++ E + T R RI +G L I A D YT A N AG
Sbjct: 3646 DAVPPPVITWLRNGERLQATPRVRI-----LSGGRYLQINNADLGDTANYTCVASNIAG 3699
Score = 78.2 bits (191), Expect = 5e-14
Identities = 75/312 (24%), Positives = 130/312 (41%), Gaps = 55/312 (17%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C++ G P P + W+KD Q++ E ++ +G L + T +D G Y+ A N
Sbjct: 1382 CEVEGTPSPIIMWYKDNVQVT---ESSTIQTVNNGKI-LKLFRATPEDAGRYSCKAINIA 1437
Query: 1026 GRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAH 1085
G ++ V P T G + P ++
Sbjct: 1438 GTSQKYFNIDVLVPP-----TIIGTNF--------------------------PNEVSVV 1466
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPV-LPDASHKMLVRETGVHSLLIDPLTQRDAGTY 1144
R L+C+V G P P++ W +G+P+ L D + ++L R +H + + D G Y
Sbjct: 1467 LNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLH---LKNARRNDKGRY 1523
Query: 1145 KCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVF 1203
+C +N G+ + ++L++ + +K V + V ++LEC G+P P
Sbjct: 1524 QCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTD----ISVLINSLIKLECETRGLPMPAI 1579
Query: 1204 YWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
W KD + I + + +++ D Y L I A+ SD+ YT N AG + +D+
Sbjct: 1580 TWYKDGQPIMSSSQ--ALYIDKGQY--LHIPRAQVSDSATYTCHVANVAGTAEKSFHVDV 1635
Query: 1264 YAQWHHQIPPPM 1275
Y PPM
Sbjct: 1636 YV-------PPM 1640
Score = 77.4 bits (189), Expect = 8e-14
Identities = 75/306 (24%), Positives = 122/306 (39%), Gaps = 61/306 (19%)
Query: 272 TQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEA 331
++ L V EGT V L+C +PPP + WY G+ + S + I+ G + L I +A
Sbjct: 3063 SESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQM--LHIKKA 3120
Query: 332 FEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP-----NEVSS 386
DTG+Y C A N+ G D + + + S EG + + I P +
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS--IEGPEREVIVETISNPVTLTCDATGI 3178
Query: 387 PPTTSAVIPP---------------------AVPQAQHLVA--QPRVATIQQCQSPTNYL 423
PP T A + + ++QH + +A+ + ++ Y
Sbjct: 3179 PPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYF 3238
Query: 424 QGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
+ P +A ++ ++S G+ V C G P+P ++W ++G
Sbjct: 3239 LSIQVPPSVAG---AEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG----------- 3284
Query: 484 LQKKPRSMAEPEEI------CTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV----- 532
KP + E E I TL I D+G +TC A+N G I L+V
Sbjct: 3285 ---KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT 3341
Query: 533 -RGNED 537
RGN+D
Sbjct: 3342 IRGNKD 3347
Score = 77.0 bits (188), Expect = 1e-13
Identities = 86/328 (26%), Positives = 128/328 (39%), Gaps = 55/328 (16%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFK-DGKQISKR----NEHCKMRREGD 999
P+F + + GS VT C + G P P + W + D I R + ++R
Sbjct: 793 PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLR---- 848
Query: 1000 GTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQ 1059
T +L I + + D G Y A N G+I + V L
Sbjct: 849 -TGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGL-------------------- 887
Query: 1060 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKV-SGLPPPELTWLLNGQPVLPDAS 1118
P +P EG+ L C + +G P PE W+ N +L +
Sbjct: 888 -----------VAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPY 936
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKL 1178
+ VR G SL I+ + +D G Y C+A+N G N+ + SVV V P I
Sbjct: 937 --ITVRSDG--SLHIERVQLQDGGEYTCVASNVAGTNNKTT--SVV---VHVLPTIQHGQ 987
Query: 1179 QNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKK 1238
Q EG PV L C+ G P P W K E I + + S D + Y ++ P +
Sbjct: 988 QILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLY---VVSPGGE 1044
Query: 1239 SDAGWYTLSAKNEAGIVSCTARLDIYAQ 1266
++G Y +A N AG +L +Y +
Sbjct: 1045 -ESGEYVCTATNTAGYAKRKVQLTVYVR 1071
Score = 75.9 bits (185), Expect = 2e-13
Identities = 66/287 (22%), Positives = 115/287 (40%), Gaps = 35/287 (12%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V G + L+C V GIPPP V W +G L + + I+ G H L + DTGRY
Sbjct: 2304 VTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEG--HILQLKNIHVSDTGRY 2361
Query: 340 SCFASNIYGTDSTSAEIYIEG----VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAV-- 393
C A N+ G ++ + + + S + + E N + E S P S
Sbjct: 2362 VCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWF 2421
Query: 394 ---IPPAVPQAQHLVAQPRVATIQQ------------CQSPTNYLQGLDGKPIIAAP--V 436
P ++ + +++ R+ + Q ++ + + G ++ P V
Sbjct: 2422 KDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIV 2481
Query: 437 FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEE 496
L+++ E Q V C V G P P++ W+++G +++ I+
Sbjct: 2482 GENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGR-------- 2533
Query: 497 ICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGS 543
L I V +G +TC AS+ G S L+V + ++ GS
Sbjct: 2534 --FLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGS 2578
Score = 75.9 bits (185), Expect = 2e-13
Identities = 76/314 (24%), Positives = 111/314 (35%), Gaps = 53/314 (16%)
Query: 963 TFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAA 1022
T C+ GIP P + W K+G ++ R G SL I S + DD Y
Sbjct: 3822 TLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSG--SLVIISPSVDDTATYECTVT 3879
Query: 1023 NPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDM 1082
N G + L VQ P P D
Sbjct: 3880 NGAGDDKRTVDLTVQ---------------------------------VPPSIADEPTDF 3906
Query: 1083 VAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAG 1142
+ + + C SG+P P + W NG +LP ++ +G +L L AG
Sbjct: 3907 LVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRIL-SSGAIEILATQLNH--AG 3963
Query: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
Y C+A N G + L V + PVI + V +P+ L C G P P
Sbjct: 3964 RYTCVARNAAGSAHRHVTL-----HVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPF 4018
Query: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLD 1262
W+K+ + + + L I A + DAG Y A+N AG +L+
Sbjct: 4019 ITWQKEGINVNTS----GRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLN 4074
Query: 1263 IYAQWHHQIPPPMS 1276
+ Q+PP +S
Sbjct: 4075 V------QVPPVIS 4082
Score = 74.7 bits (182), Expect = 5e-13
Identities = 76/320 (23%), Positives = 118/320 (36%), Gaps = 63/320 (19%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C G+P P++ W KDG ++ + + G LHI+S D G Y MA N
Sbjct: 3734 CIAEGVPTPRITWRKDGAVLAGNHARYSILENG----FLHIQSAHVTDTGRYLCMATNAA 3789
Query: 1026 GRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAH 1085
G R R+ + P P P +M
Sbjct: 3790 GT--------------------------DRRRIDLQVHVP-------PSIAPGPTNMTVI 3816
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYK 1145
L C+ +G+P P + W NG + D + R SL+I + D TY+
Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNS-YRLLSSGSLVIISPSVDDTATYE 3875
Query: 1146 CIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYW 1205
C TN G + +++L+ V+ P I ++ + V + P + C G+P P +W
Sbjct: 3876 CTVTNGAGDDKRTVDLT-----VQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHW 3930
Query: 1206 KKDNETIPCTRERISMHQDTTGYACLL-----IQPAKKSDAGWYTLSAKNEAGIVSCTAR 1260
T+ I + GY L I + + AG YT A+N AG
Sbjct: 3931 ---------TKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVT 3981
Query: 1261 LDIYAQWHHQIPPPMSVRPS 1280
L ++ PP + +PS
Sbjct: 3982 LHVHE------PPVIQPQPS 3995
Score = 74.3 bits (181), Expect = 7e-13
Identities = 75/296 (25%), Positives = 116/296 (39%), Gaps = 53/296 (17%)
Query: 962 VTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMA 1021
+ C+ G P P++ W K+G + + H ++ G + I D YT +A
Sbjct: 3360 INIECRATGTPPPQINWLKNGLPLPL-SSHIRLLAAGQ---VIRIVRAQVSDVAVYTCVA 3415
Query: 1022 ANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPG- 1080
+N G + +L V F P+ + G
Sbjct: 3416 SNRAGVDNKHYNLQV---------------------------------FAPPNMDNSMGT 3442
Query: 1081 -DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
++ +G + C G P P + WL +GQP+ DA + V G+ L+ T+
Sbjct: 3443 EEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAH--LTVSTHGMVLQLLKAETE- 3499
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQNCGVPEGHPVRLECRVIG 1197
D+G Y CIA+N+ G+ S L V+ + P I E+ + V +P+ L C G
Sbjct: 3500 DSGKYTCIASNEAGEVSKHFILKVL-----EPPHINGSEEHEEISVIVNNPLELTCIASG 3554
Query: 1198 MPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+P P W KD +P T Q G L I A+ D G YT A + AG
Sbjct: 3555 IPAPKMTWMKDGRPLPQT----DQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAG 3606
Score = 71.2 bits (173), Expect = 6e-12
Identities = 81/349 (23%), Positives = 133/349 (38%), Gaps = 53/349 (15%)
Query: 926 DESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQI 985
DE++ + E PT + + P ++ + RV + F C G P P + W +G+++
Sbjct: 1250 DETEITLHVQEPPTVEDLEPPYNTTFQE-RVAN-QRIEFPCPAKGTPKPTIKWLHNGREL 1307
Query: 986 SKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRL 1045
+ R + +G L I S T D+G Y +A N G +L V P+
Sbjct: 1308 TGREPGISILEDGT---LLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVI--- 1361
Query: 1046 TSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELT 1105
+DKE + ++ +L L C+V G P P +
Sbjct: 1362 ---------------KDKEQVT-------------NVSVLLNQLTNLFCEVEGTPSPIIM 1393
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W + V ++ + + L + T DAG Y C A N G + + V+
Sbjct: 1394 WYKDNVQVTESSTIQTV---NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLV 1450
Query: 1166 KEVKKAPVILEKLQN-CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQD 1224
+I N V V LEC+V G P P +W KD + + + +
Sbjct: 1451 PPT----IIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVEL--- 1503
Query: 1225 TTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
L ++ A+++D G Y + N AG + +L IY IPP
Sbjct: 1504 LDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY------IPP 1546
Score = 71.2 bits (173), Expect = 6e-12
Identities = 79/337 (23%), Positives = 134/337 (39%), Gaps = 55/337 (16%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
++L CI GIP P++ W +G+ L + + + G + L I+ A EDTGRY+C AS+
Sbjct: 3546 LELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV--LRISTAQVEDTGRYTCLASS 3603
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVP---QAQ 402
G D Y+ V + ++ + + +V+ + AV PP + +
Sbjct: 3604 PAGDDDKE---YLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE 3660
Query: 403 HLVAQPRV-------------ATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEG 449
L A PRV A + + T + GK + + N+
Sbjct: 3661 RLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQ 3720
Query: 450 QLV-------VFECRVKGAPSPKVEWYREGTLIE-DSPDFRILQKKPRSMAEPEEICTLV 501
LV V EC +G P+P++ W ++G ++ + + IL+ L
Sbjct: 3721 SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENG-----------FLH 3769
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPS 561
I D+G + C A+N GT R DL + A TN+ I +
Sbjct: 3770 IQSAHVTDTGRYLCMATNAAGT--------DRRRIDLQVHVPPSIAPGPTNMTVIVNVQT 3821
Query: 562 PPHSEPPSVEQPPKPKL----EGVLVNHNEPRSSSRI 594
E + PKP + G L+N ++ ++S R+
Sbjct: 3822 TLACEATGI---PKPSINWRKNGHLLNVDQNQNSYRL 3855
Score = 69.7 bits (169), Expect = 2e-11
Identities = 72/302 (23%), Positives = 105/302 (34%), Gaps = 88/302 (29%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP+ + + +V G RV + C G P P + W G + + H+ +L+
Sbjct: 1170 PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG--TLS 1227
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSP 387
I +A D G Y+C A+NI GTD T ++++ P
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQ--------------------------EP 1261
Query: 388 PTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSAS 447
PT + PP Q VA R+
Sbjct: 1262 PTVEDLEPPYNTTFQERVANQRIE------------------------------------ 1285
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFA 507
F C KG P P ++W G R L + ++ E+ LVIA V
Sbjct: 1286 ------FPCPAKGTPKPTIKWLHNG---------RELTGREPGISILEDGTLLVIASVTP 1330
Query: 508 EDSGCFTCTASNKYGTVSSIAQLHV------RGNEDLSNNGSLHSANSTTNL-AAIEPQP 560
D+G + C A N+ GT L V + E ++N L N TNL +E P
Sbjct: 1331 YDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVL--LNQLTNLFCEVEGTP 1388
Query: 561 SP 562
SP
Sbjct: 1389 SP 1390
Score = 68.9 bits (167), Expect = 3e-11
Identities = 69/319 (21%), Positives = 122/319 (38%), Gaps = 61/319 (19%)
Query: 260 YYEEPLGQPPRFTQKLRSREVPE------GTRVQLDCIVVGIPPPQVRWYCEGKELENSP 313
YY + PP + E+P G V+L C GIP P ++W +GK + +
Sbjct: 3236 YYFLSIQVPP----SVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE 3291
Query: 314 DIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE 373
I + N +L I A DTG+Y+C A+N G + + + + D ++
Sbjct: 3292 TERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEK 3351
Query: 374 EMNRIQKPNEVSSPPTTSAVIPPAV---------PQAQHL----------VAQPRVATIQ 414
M + + T + PP + P + H+ + + +V+ +
Sbjct: 3352 LMTLVDTSINIECRATGTP--PPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVA 3409
Query: 415 QCQSPTNYLQGLDGK----PIIAAPVFTKML--QNLSASEGQLVVFECRVKGAPSPKVEW 468
+ G+D K + A P + + ++ +G C G P+P + W
Sbjct: 3410 VYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW 3469
Query: 469 YREGTLIEDSPDFRILQKKPRSMAEPEEICT----LVIAEVFAEDSGCFTCTASNKYGTV 524
R+G +P + + T L + + EDSG +TC ASN+ G V
Sbjct: 3470 LRDG--------------QPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEV 3515
Query: 525 SS------IAQLHVRGNED 537
S + H+ G+E+
Sbjct: 3516 SKHFILKVLEPPHINGSEE 3534
Score = 66.2 bits (160), Expect = 2e-10
Identities = 70/275 (25%), Positives = 114/275 (41%), Gaps = 32/275 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PPR V E ++ L C+ GIP P + W + L N + + L
Sbjct: 4168 PPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYG--ELI 4225
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSS-SDSEGDP--NKEEMNRIQ-KPNE 383
+ ED+G Y+C A+N G D+ + + + + + ++ GD NK E R+ K
Sbjct: 4226 LENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATG 4285
Query: 384 VSSPPTT----SAVIPP---AVPQAQHLVAQPRVAT------IQQCQSPTNYLQGLDGKP 430
+ P T + +IP +V LV + RV+ + ++ +++ +
Sbjct: 4286 IPLPKLTWTFNNNIIPAHFDSVNGHSELVIE-RVSKEDSGTYVCTAENSVGFVKAIGFVY 4344
Query: 431 IIAAPVFT-KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPR 489
+ PVF N G + C VKG P+P ++W R+G IE S R L
Sbjct: 4345 VKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNG-- 4402
Query: 490 SMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTV 524
+L I ED+G +TC A+N+ G V
Sbjct: 4403 ---------SLAIYGTVNEDAGDYTCVATNEAGVV 4428
Score = 65.1 bits (157), Expect = 4e-10
Identities = 80/328 (24%), Positives = 125/328 (38%), Gaps = 47/328 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP + ++ V V+L C IPPP + W +G L P + I + N L
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISE--NRSVLK 2160
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYI---EGVSSSDS-------EGDPNKE--EM 375
I +A +DTGRY+C A+N+ G + + I + SD EG+ E
Sbjct: 2161 IEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCES 2220
Query: 376 NRIQKPNEV----SSPPTTSAV----IPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLD 427
+ I PN + SP T ++ I Q Q +A+ A + C + + + G
Sbjct: 2221 SGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVA--SNVAGTA 2278
Query: 428 GK----PIIAAPVFTKMLQN---LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
K + P T + + + G+ + EC V+G P P V W ++G + +
Sbjct: 2279 KKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKG 2338
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR------G 534
IL +E L + + D+G + C A N G L V G
Sbjct: 2339 VEIL----------DEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIG 2388
Query: 535 NEDLSNNGSLHSANSTTNLAAIEPQPSP 562
N N S+ NS + P P
Sbjct: 2389 NHRSPENISVVEKNSVSLTCEASGIPLP 2416
Score = 63.5 bits (153), Expect = 1e-09
Identities = 92/419 (21%), Positives = 155/419 (36%), Gaps = 48/419 (11%)
Query: 185 LESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRR----EAEQ 240
LE K++ E + + + + P+P+ +DN + R + E
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIES 1980
Query: 241 AASEAAG---GDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPP 297
A AG + + L+Y + P + V V+L+C GIP
Sbjct: 1981 AQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPA 2040
Query: 298 PQVRWYCEGKELEN-SPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEI 356
P + W +G + + S + ++ G + +LT A+ DTGRY+C A N G ++
Sbjct: 2041 PSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQI--SDTGRYTCVAVNAAGEKQRDIDL 2098
Query: 357 ---------------------YIEGVSSSDSEGDPN----KEEMNRIQKPNEVSSPPTTS 391
+E + SD+ P K+ ++KP S +
Sbjct: 2099 RVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV 2158
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQL 451
I A Q Q AT ++ NY + P I + L L+ EG L
Sbjct: 2159 LKIEDA--QVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGG---SDELTQLTVIEGNL 2213
Query: 452 VVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSG 511
+ C G P P + W ++G SP + R ++ ++ + IAE D+
Sbjct: 2214 ISLLCESSGIPPPNLIWKKKG-----SPVLTDSMGRVRILSGGRQL-QISIAE--KSDAA 2265
Query: 512 CFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAIEPQPSPPHSEPPSV 570
++C ASN GT L V ++N+GS + T +I + PP+V
Sbjct: 2266 LYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTV 2324
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/299 (23%), Positives = 116/299 (38%), Gaps = 50/299 (16%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP------DIHIV 318
+G PP F Q+ + G+ V L C V G P P ++W + L+N P + +
Sbjct: 789 VGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW----RRLDNMPIFSRPFSVSSI 844
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
+L I + D G Y C A N +G + + + G+ + P+ + +
Sbjct: 845 SQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPS---VANV 901
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQ-----HLVAQPRVATIQ----------QCQSPTNY- 422
+ +++ P T A P +P+ + ++ Q T++ Q Q Y
Sbjct: 902 IEGQQLTLPCTLLAGNP--IPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYT 959
Query: 423 -----LQGLDGKP----IIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGT 473
+ G + K + P Q LS EG V C+ G P P V W ++G
Sbjct: 960 CVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGE 1019
Query: 474 LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
LI S K + A+ +L + E+SG + CTA+N G QL V
Sbjct: 1020 LISTS------SAKFSAGADG----SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Score = 62.4 bits (150), Expect = 3e-09
Identities = 78/336 (23%), Positives = 114/336 (33%), Gaps = 98/336 (29%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
V L C GIPPP + W K +ENS + + L IA + D+G Y+C ASN
Sbjct: 3169 VTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASN 3228
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLV 405
+ EG K IQ P P A IP V L+
Sbjct: 3229 M--------------------EGKAQKYYFLSIQVP-----PSVAGAEIPSDVSV---LL 3260
Query: 406 AQPRVATIQQCQSPTNYLQGL-DGKPIIAAPV------------------------FTKM 440
+ PT +Q L DGKPI + +T +
Sbjct: 3261 GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCV 3320
Query: 441 LQNLSASEGQL----------------------------VVFECRVKGAPSPKVEWYREG 472
N + E ++ + ECR G P P++ W + G
Sbjct: 3321 ATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380
Query: 473 TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ S R+L ++ +V A+V D +TC ASN+ G + L V
Sbjct: 3381 LPLPLSSHIRLLAAG--------QVIRIVRAQV--SDVAVYTCVASNRAGVDNKHYNLQV 3430
Query: 533 RGNEDLSNNGSLHS----ANSTTNLAAI---EPQPS 561
++ N+ S+T++A I P PS
Sbjct: 3431 FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPS 3466
Score = 61.6 bits (148), Expect = 5e-09
Identities = 65/282 (23%), Positives = 101/282 (35%), Gaps = 49/282 (17%)
Query: 275 LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEE 334
L +V E V L C V G P P++ W+ +G+ L+ HI+ G +T +
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQV--P 2543
Query: 335 DTGRYSCFASNIYGTDSTSAEIYI---EGVSSSDSEGDPNKEEMNRIQKPNEV-----SS 386
TGRY+C AS+ G S S + + ++ S+G+P + + P + S
Sbjct: 2544 HTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVI-LNSPTSLVCEAYSY 2602
Query: 387 PPTTSAVIPPAVP--------------QAQHLVAQPRVATIQQCQSPTN----------- 421
PP T P Q L AQ A C +
Sbjct: 2603 PPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK 2662
Query: 422 -YLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
Y+ + K + P + + + + EC PS + WY++G ++
Sbjct: 2663 VYIPPIINKGDLWGPGLSP--KEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
I TL I E D+G +TC ASN G
Sbjct: 2721 VNIAANGH----------TLQIKEAQISDTGRYTCVASNIAG 2752
Score = 60.8 bits (146), Expect = 8e-09
Identities = 62/279 (22%), Positives = 105/279 (37%), Gaps = 46/279 (16%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C IP + WY +G+ L++ D H+ A N H+L I EA DTGRY+C ASNI
Sbjct: 2694 LECEAYAIPSASLSWYKDGQPLKS--DDHVNIAANGHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 348 GTDSTSAEIYIEGVSS-------SDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAV-- 398
G D ++ I+ S + E + N +S T+A PP +
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811
Query: 399 -PQAQHLVAQPRV-------------ATIQQCQSPTNYLQGLDGKP-------IIAAPVF 437
L + +V A ++ T G+ ++ P+
Sbjct: 2812 YKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPII 2871
Query: 438 ----TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
+ + + ++ + + EC G+P+P+ W ++G + + + L
Sbjct: 2872 KGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGR----- 2926
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
L I D G + C A N G+ L+V
Sbjct: 2927 -----ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNV 2960
Score = 60.1 bits (144), Expect = 1e-08
Identities = 64/293 (21%), Positives = 112/293 (38%), Gaps = 46/293 (15%)
Query: 261 YEEPLGQPPRFTQKLRSRE---VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHI 317
Y+ + PP RS E V E V L C GIP P + W+ +G + S + I
Sbjct: 2376 YDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRI 2435
Query: 318 VQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD------STSAEIYIEGVSSSDSEGDPN 371
+ G + L + + ED G+Y+C N G + S +I G ++ + D
Sbjct: 2436 LSGGRM--LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLE---DVK 2490
Query: 372 KEEMNRIQKPNEVSSPPTTSAVI-----PPAVPQAQHLVAQPRVATIQQCQSP-TNYLQG 425
+E + EV+ P P +A H+++ R I Q P T
Sbjct: 2491 VKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC 2550
Query: 426 LDGKP-----------IIAAPVFTKMLQNLSASEGQLVV-----FECRVKGAPSPKVEWY 469
L P + +P + + + + +++ C P + W+
Sbjct: 2551 LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWF 2610
Query: 470 REGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
++GT +E + + RIL TL I +++G ++C A+N+ G
Sbjct: 2611 KDGTPLESNRNIRILPGGR----------TLQILNAQEDNAGRYSCVATNEAG 2653
Score = 59.3 bits (142), Expect = 2e-08
Identities = 79/304 (25%), Positives = 106/304 (34%), Gaps = 41/304 (13%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L C V G P P + WY + ++ S I V G + L + A ED GRYSC A NI
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKI--LKLFRATPEDAGRYSCKAINIA 1437
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEE--MNR-IQKPNEVSSPPTTSA----------VI 394
GT I + + PN+ +NR + +V P +
Sbjct: 1438 GTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG 1497
Query: 395 PPAVP-----QAQHLVAQPR--VATIQQCQSPTNYLQGLDGKPIIAAPVFTK---MLQNL 444
P V Q HL R Q S Q D K I P K + ++
Sbjct: 1498 DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDI 1557
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
S L+ EC +G P P + WY++G I S + K L I
Sbjct: 1558 SVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ----------YLHIPR 1607
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV------RGNEDLSNNGSLHSANSTTNLAAIEP 558
DS +TC +N GT + V GN N + A+S T
Sbjct: 1608 AQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAG 1667
Query: 559 QPSP 562
PSP
Sbjct: 1668 NPSP 1671
Score = 59.3 bits (142), Expect = 2e-08
Identities = 68/301 (22%), Positives = 107/301 (35%), Gaps = 78/301 (25%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
++LDC V G PPP + W +G+ ++ I+ G L IA+A +TG Y C A+N
Sbjct: 1752 LELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNG--RKLVIAQAQVSNTGLYRCMAAN 1809
Query: 346 IYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLV 405
+ GD KE + P + S + V+ P A +
Sbjct: 1810 --------------------TAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCI 1849
Query: 406 A----QPRVATIQQCQSPTNYLQG-----LDGKPIIAAPV-------FTKMLQNLSASEG 449
A P + ++ Q P N QG G+ + A +T + N +
Sbjct: 1850 ANGIPNPSITWLKDDQ-PVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQ 1908
Query: 450 Q---------------------------LVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
Q V EC+ G P P + WY++ L+ S
Sbjct: 1909 QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMT 1968
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSI--AQLHVRGNEDLSN 540
L + +I + A++ D+G + C A N G Q+HV + SN
Sbjct: 1969 FLNR--------GQIIDIESAQI--SDAGIYKCVAINSAGATELFYSLQVHVAPSISGSN 2018
Query: 541 N 541
N
Sbjct: 2019 N 2019
Score = 58.5 bits (140), Expect = 4e-08
Identities = 62/288 (21%), Positives = 103/288 (35%), Gaps = 41/288 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEG-KELENSPDIHIVQAGNLHSL 326
PP + V + + C G+P P + W G + L I+ +G ++
Sbjct: 3896 PPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSG---AI 3952
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEM-----NRIQKP 381
I GRY+C A N G+ +++ P E+ N I P
Sbjct: 3953 EILATQLNHAGRYTCVARNAAGSAHRHVTLHVH----EPPVIQPQPSELHVILNNPILLP 4008
Query: 382 NEVSSPPT-----------------TSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQ 424
E + P+ AV+P Q V + + Q+P
Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTAL 4068
Query: 425 GLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
G + PV + L+ + + + C G P P + W+++G I +S R+L
Sbjct: 4069 GKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVL 4128
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+L IA V D+G +TC A+N G+ S+ +L V
Sbjct: 4129 SSG-----------SLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Score = 57.8 bits (138), Expect = 7e-08
Identities = 60/290 (20%), Positives = 114/290 (39%), Gaps = 34/290 (11%)
Query: 277 SREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT 336
+++V + L+C G P P + W +G ++ + +I I G L I A E D
Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGK--KLEIMSAQEIDR 1707
Query: 337 GRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVS-----SPPTTS 391
G+Y C A+++ G E+ + V + GD + + E+ SPP T
Sbjct: 1708 GQYICVATSVAGEKEIKYEVDVL-VPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTI 1766
Query: 392 AVIPPA------------VPQAQHLVAQPRVAT--IQQCQSPT---NYLQGLDGKPIIAA 434
+ + + ++AQ +V+ + +C + ++ + + +
Sbjct: 1767 MWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP 1826
Query: 435 PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
+ + L + + V +C G P+P + W ++ + + +Q R
Sbjct: 1827 TIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGR----- 1881
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSL 544
L IA+ ED+G +TC A+N G QLHV L + G +
Sbjct: 1882 ----VLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKM 1927
Score = 57.4 bits (137), Expect = 9e-08
Identities = 73/305 (23%), Positives = 113/305 (37%), Gaps = 50/305 (16%)
Query: 249 DTTPGSSPSSLYYEEPLGQPPRFT-QKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK 307
+ T GS+ Y+ + PP K + V + L C V G PPP + W +
Sbjct: 2946 ENTAGSAKK--YFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQ 3003
Query: 308 ELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSE 367
++ + + IV G +L I A D G Y+C A N G + + V S +
Sbjct: 3004 PIKLNTNTLIVPGG--RTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY-VPPSIKD 3060
Query: 368 GDPNKEEMNRIQKPNEVSSPPTTSAVIPPA---------VPQAQHL----------VAQP 408
D + +++ VS ++AV PP + ++ H+ + +
Sbjct: 3061 HDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKA 3120
Query: 409 RVATIQQCQSPTNYLQGLDGK---------PIIAAPVFTKMLQNLSASEGQLVVFECRVK 459
V+ Q + G D K P I P +++ +S V C
Sbjct: 3121 EVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETIS----NPVTLTCDAT 3176
Query: 460 GAPSPKVEWYREGTLIE--DSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTA 517
G P P + W + IE DS + RIL + L IA DSG +TC A
Sbjct: 3177 GIPPPTIAWLKNHKRIENSDSLEVRILSGGSK----------LQIARSQHSDSGNYTCIA 3226
Query: 518 SNKYG 522
SN G
Sbjct: 3227 SNMEG 3231
Score = 57.0 bits (136), Expect = 1e-07
Identities = 67/278 (24%), Positives = 102/278 (36%), Gaps = 38/278 (13%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
EG V L C G P P V W +G+ + S AG SL + E++G Y C
Sbjct: 994 EGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKF--SAGADGSLYVVSPGGEESGEYVC 1051
Query: 342 FASNI--YGTDSTSAEIYIEGVSSSDSEGDPNKEEMN-------RIQKPNEVSSPPTT-- 390
A+N Y +Y+ D G + + + P EV S P
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII 1111
Query: 391 -----SAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYL---QGLDGKPIIAA-------P 435
+ +I P P+ L + T + YL + G A P
Sbjct: 1112 TWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP 1171
Query: 436 VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPE 495
+ ++L GQ V C +G P P + W + G+ + L ++ P+
Sbjct: 1172 KIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTM--------LVDGEHHVSNPD 1223
Query: 496 EICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
TL I + D+G +TC A+N GT + LHV+
Sbjct: 1224 G--TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQ 1259
Score = 57.0 bits (136), Expect = 1e-07
Identities = 72/312 (23%), Positives = 111/312 (35%), Gaps = 63/312 (20%)
Query: 242 ASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVR 301
A+ AAG DT S + P FT+ + +G +++L C GIP P++
Sbjct: 4241 ANNAAGEDTHTVSLTVHVL--------PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLT 4292
Query: 302 WYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE-- 359
W N H L I +ED+G Y C A N G +Y++
Sbjct: 4293 WTFNN----NIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP 4348
Query: 360 ------------------GVSSSDSEGDPNKE-EMNR----IQKPNEVSSPPTTSAVIPP 396
+ + + +GDP + NR I+ + + S I
Sbjct: 4349 PVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYG 4408
Query: 397 AVPQAQH---LVAQPRVATIQQCQSPTNYLQGLDGKPIIAA-PVFTKMLQNLSASEGQLV 452
V + VA +++ S T L PII PV T + + G +
Sbjct: 4409 TVNEDAGDYTCVATNEAGVVERSMSLT-----LQSPPIITLEPVETVI------NAGGKI 4457
Query: 453 VFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGC 512
+ C+ G P P + W R+G I +L +L IA+ ED+
Sbjct: 4458 ILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNN-----------SLYIADAQKEDTSE 4506
Query: 513 FTCTASNKYGTV 524
F C A N G+V
Sbjct: 4507 FECVARNLMGSV 4518
Score = 56.6 bits (135), Expect = 2e-07
Identities = 74/313 (23%), Positives = 117/313 (37%), Gaps = 55/313 (17%)
Query: 242 ASEAAGGDTTPGSSPSSLYYEEPLG----QPPRFTQKLRSREVPEGTRVQLDCIVVGIPP 297
A+ AG D T +L+ +EP +PP T +E R++ C G P
Sbjct: 1243 ATNIAGTDETE----ITLHVQEPPTVEDLEPPYNTT---FQERVANQRIEFPCPAKGTPK 1295
Query: 298 PQVRWYCEGKELE-NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDS----- 351
P ++W G+EL P I I++ G L L IA D G Y C A N GT
Sbjct: 1296 PTIKWLHNGRELTGREPGISILEDGTL--LVIASVTPYDNGEYICVAVNEAGTTERKYNL 1353
Query: 352 --------------TSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN-EVSSPPTTSAVIPP 396
T+ + + +++ E + + K N +V+ T V
Sbjct: 1354 KVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNG 1413
Query: 397 AVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK----PIIAAP--VFTKMLQNLSASEGQ 450
+ + A P A C++ + G K ++ P + T +S +
Sbjct: 1414 KI--LKLFRATPEDAGRYSCKAIN--IAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNR 1469
Query: 451 LVVFECRVKGAPSPKVEWYREG-TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAED 509
V EC+VKG P P + W+++G L P+ +L + L + D
Sbjct: 1470 DVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQ----------VLHLKNARRND 1519
Query: 510 SGCFTCTASNKYG 522
G + CT SN G
Sbjct: 1520 KGRYQCTVSNAAG 1532
Score = 56.2 bits (134), Expect = 2e-07
Identities = 72/293 (24%), Positives = 106/293 (36%), Gaps = 49/293 (16%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP + V + L C G P P + W EG + S H V L
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSG--GL 4043
Query: 327 TIAEAFEEDTGRYSCFASNIYGT--DSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
I+ A ED G Y C A N GT + + V S KE + + KP +
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHL-----KEYVIAVDKPITL 4098
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNL 444
S + PP + H + V +I+Q + LQ +P A +T M N+
Sbjct: 4099 SC--EADGLPPPDI--TWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGH-YTCMAANV 4153
Query: 445 SAS-------------------------EGQLVVFECRVKGAPSPKVEWYREGTLIEDSP 479
+ S E + C G P+P + W ++ L+ +
Sbjct: 4154 AGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLAN-- 4211
Query: 480 DFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+L K AEP L++ V EDSG +TC A+N G + L V
Sbjct: 4212 ---LLGK---YTAEP--YGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 55.8 bits (133), Expect = 3e-07
Identities = 48/181 (26%), Positives = 72/181 (39%), Gaps = 12/181 (6%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P +Q P ++ G L C + LTW N + V + +R SL
Sbjct: 520 PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVR--LAEPARIRTLANLSLE 577
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ + DAG Y C+ +++ G ++ S+ L+ V++ P + +N G V +
Sbjct: 578 LKSVKFNDAGEYHCMVSSEGGSSAASVFLT-----VQEPPKVTVMPKNQSFTGGSEVSIM 632
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C G P P W N+ R M D T L I+ A DAG Y A N A
Sbjct: 633 CSATGYPKPKIAWTV-NDMFIVGSHRYRMTSDGT----LFIKNAAPKDAGIYGCLASNSA 687
Query: 1253 G 1253
G
Sbjct: 688 G 688
Score = 54.7 bits (130), Expect = 6e-07
Identities = 65/288 (22%), Positives = 108/288 (37%), Gaps = 41/288 (14%)
Query: 261 YEEPLGQPPRFTQK-LRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSP-DIHIV 318
+E + PP L R V + V L CI GIP P + W + + + + ++ I
Sbjct: 1818 FEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQ 1877
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEM--- 375
+G + L IA+ ED GRY+C A+N G ++++ S + G E +
Sbjct: 1878 SSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVS 1935
Query: 376 NRIQ----------------KPNEVSSPPTTSAVIPPA----VPQAQHLVAQPRVATIQQ 415
N +Q K N + S T+ + + AQ A
Sbjct: 1936 NPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAIN 1995
Query: 416 CQSPTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLI 475
T L + AP + ++ V EC +G P+P + W ++G+ +
Sbjct: 1996 SAGATELFYSLQ---VHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPV 2052
Query: 476 ED-SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
S ++L I L A++ D+G +TC A N G
Sbjct: 2053 SSFSNGLQVL--------SGGRILALTSAQI--SDTGRYTCVAVNAAG 2090
Score = 54.7 bits (130), Expect = 6e-07
Identities = 78/324 (24%), Positives = 120/324 (37%), Gaps = 49/324 (15%)
Query: 241 AASEAAGGDTTPGSSPSSLYYEEPLGQ---PPRF--TQKLRSREVPEGTRVQLDCIVVGI 295
A E G T SSP+ +E L + PP T + R V +V L+C +
Sbjct: 3589 AQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAV 3648
Query: 296 PPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAE 355
PPP + W G+ L+ +P + I+ G L I A DT Y+C ASNI G T+ E
Sbjct: 3649 PPPVITWLRNGERLQATPRVRILSGGRY--LQINNADLGDTANYTCVASNIAG--KTTRE 3704
Query: 356 IYIEGVSSSDSEGDP-------NKEEMNRIQKPNEVSSPPTT----SAVIPPAVPQAQHL 404
+ + +G P NK + V +P T AV+ A A++
Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKSTVLECIAEG-VPTPRITWRKDGAVL--AGNHARYS 3761
Query: 405 VAQPRVATIQQCQ--SPTNYL------QGLDGK----PIIAAPVFTKMLQNLSASEGQLV 452
+ + IQ YL G D + + P N++
Sbjct: 3762 ILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQT 3821
Query: 453 VFECRVKGAPSPKVEWYREGTLI---EDSPDFRILQKKPRSMAEPEEICTLVIAEVFAED 509
C G P P + W + G L+ ++ +R+L +LVI +D
Sbjct: 3822 TLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSG-----------SLVIISPSVDD 3870
Query: 510 SGCFTCTASNKYGTVSSIAQLHVR 533
+ + CT +N G L V+
Sbjct: 3871 TATYECTVTNGAGDDKRTVDLTVQ 3894
Score = 53.1 bits (126), Expect = 2e-06
Identities = 78/350 (22%), Positives = 125/350 (35%), Gaps = 73/350 (20%)
Query: 221 DNEVN-----HALEQQEAKRREAEQ---AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFT 272
D+ VN H L+ +EA+ + + AS AG D L ++ + PP F
Sbjct: 2718 DDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGED--------ELDFDVNIQVPPSF- 2768
Query: 273 QKL-------------RSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQ 319
QKL +++V + L C PPP + WY +G L +S + I+
Sbjct: 2769 QKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILP 2828
Query: 320 AGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQ 379
G + L I A ED GRY+C A N G DS ++ + EE+ +
Sbjct: 2829 GGRV--LQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLV 2886
Query: 380 KPNEVSSPPTTSAVIP---------PAVPQAQH-LVAQPRVATIQQCQ------------ 417
+ + ++ + P P + H ++ R+ I Q
Sbjct: 2887 NKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAE 2946
Query: 418 ----SPTNYLQ-GLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREG 472
S Y + P + P +NL+ + C V G P P + W +
Sbjct: 2947 NTAGSAKKYFNLNVHVPPSVIGP----KSENLTVVVNNFISLTCEVSGFPPPDLSWLKNE 3002
Query: 473 TLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
I+ + + I+ TL I D G +TC A N+ G
Sbjct: 3003 QPIKLNTNTLIVPGGR----------TLQIIRAKVSDGGEYTCIAINQAG 3042
Score = 48.9 bits (115), Expect = 3e-05
Identities = 63/311 (20%), Positives = 117/311 (37%), Gaps = 52/311 (16%)
Query: 250 TTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL 309
++ G+ + +++ + +PP Q + V G R L C+++ + W +++
Sbjct: 503 SSAGTGRAQTFFD--VSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDV 560
Query: 310 ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGD 369
+ I NL SL + D G Y C S+ G+ + S + + +
Sbjct: 561 RLAEPARIRTLANL-SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTV--------QEP 611
Query: 370 PNKEEMNRIQK---PNEVSSPPTTSAVIPPAVPQAQHLV--------------------A 406
P M + Q +EVS + + P + + + A
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNA 671
Query: 407 QPRVATIQQCQSPTNYLQGLDGK----PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAP 462
P+ A I C + + G D + I AP + L + G + V EC+ G P
Sbjct: 672 APKDAGIYGCLASNS--AGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIP 729
Query: 463 SPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV-IAEVFAEDSGCFTCTASNKY 521
P+V+W++ L+ +P + + + L+ I E D+G +TC A N+
Sbjct: 730 PPQVKWFKGD-----------LELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEA 778
Query: 522 GTVSSIAQLHV 532
G + L V
Sbjct: 779 GRATGKITLDV 789
Score = 47.4 bits (111), Expect = 9e-05
Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 6/132 (4%)
Query: 221 DNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEE---PLGQPPRFTQKLRS 277
D E++H + Q +E AG T ++ + + L PP T +
Sbjct: 4389 DIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVE 4448
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
+ G ++ L+C G P P + W +G + ++++ + +SL IA+A +EDT
Sbjct: 4449 TVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVL---SNNSLYIADAQKEDTS 4505
Query: 338 RYSCFASNIYGT 349
+ C A N+ G+
Sbjct: 4506 EFECVARNLMGS 4517
Score = 47.0 bits (110), Expect = 1e-04
Identities = 50/225 (22%), Positives = 88/225 (39%), Gaps = 32/225 (14%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKEL-ENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFAS 344
V L+C V G P P + W+ +GK L P++ ++ G + L + A D GRY C S
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV--LHLKNARRNDKGRYQCTVS 1528
Query: 345 NIYGTDSTSAEIYI---EGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVI----PPA 397
N G + ++ I + + D + + I+ E P + P
Sbjct: 1529 NAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPI 1588
Query: 398 VPQAQHLVAQ-------PRVATIQQCQSPTNYLQGLDG------------KPIIAAPVFT 438
+ +Q L PR A + + T ++ + G P+I + T
Sbjct: 1589 MSSSQALYIDKGQYLHIPR-AQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLAT 1647
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRI 483
+ N + EC+ G PSP + W ++G ++ + + RI
Sbjct: 1648 PL--NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRI 1690
Score = 46.6 bits (109), Expect = 2e-04
Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 18/194 (9%)
Query: 1091 RLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATN 1150
++ C V L P L+++ NG + D ++E+ +L I +T D G Y+CIA +
Sbjct: 448 QIPCSVDSLLPFTLSFVRNGVTLGVD----QYLKESASVNLDIAKVTLSDEGFYECIAVS 503
Query: 1151 KTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNE 1210
G + +V + P +++ N V G L C +I W++++
Sbjct: 504 SAGTGR-----AQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDR 558
Query: 1211 TIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQ 1270
+ R T L ++ K +DAG Y +E G + + L + Q
Sbjct: 559 DV---RLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTV------Q 609
Query: 1271 IPPPMSVRPSGSRY 1284
PP ++V P +
Sbjct: 610 EPPKVTVMPKNQSF 623
Score = 45.4 bits (106), Expect = 4e-04
Identities = 59/307 (19%), Positives = 93/307 (30%), Gaps = 74/307 (24%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKEL---ENSPDIHIVQAGNLH 324
PP + V + L C GIP P + W G L +N ++ +G
Sbjct: 3803 PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSG--- 3859
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV 384
SL I +DT Y C +N G D + ++ +Q P +
Sbjct: 3860 SLVIISPSVDDTATYECTVTNGAGDDKRTVDL--------------------TVQVPPSI 3899
Query: 385 SSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAA---------- 434
+ PT V A + +I ++ L DG I+++
Sbjct: 3900 ADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL 3959
Query: 435 ----------------------------PVFTKMLQNLSASEGQLVVFECRVKGAPSPKV 466
PV L ++ C G PSP +
Sbjct: 3960 NHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFI 4019
Query: 467 EWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSS 526
W +EG + S + L I+ ED+G + C A N GT
Sbjct: 4020 TWQKEGINVNTSGRNHAVLPSGG----------LQISRAVREDAGTYMCVAQNPAGTALG 4069
Query: 527 IAQLHVR 533
+L+V+
Sbjct: 4070 KIKLNVQ 4076
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 108 bits (270), Expect = 3e-23
Identities = 93/338 (27%), Positives = 136/338 (40%), Gaps = 54/338 (15%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P+ + L TEGS CK G P P + W KDG+ +S ++ G+
Sbjct: 2754 VPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE--- 2810
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L +++ D G YT A N GR HL + LP+
Sbjct: 2811 -LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV--------------------- 2848
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F PGD G L C G P P + W +N +PV S
Sbjct: 2849 ------------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS---- 2892
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL-EKLQNC 1181
+ G +L +++ D+GTY C A N+ G+ +V VK+APV+ E
Sbjct: 2893 -EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ-----AVSFVHVKEAPVLQGEAFSYL 2946
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
P G ++L+C V G P P +W KD + + R HQ G L I+ ++ DA
Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLR---HQLQNG--SLTIRRTERDDA 3001
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQI-PPPMSVR 1278
G Y A+NE G+ L + + Q+ P M+VR
Sbjct: 3002 GRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVR 3039
Score = 100 bits (249), Expect = 9e-21
Identities = 100/364 (27%), Positives = 140/364 (38%), Gaps = 73/364 (20%)
Query: 939 TGKCIAPIF--DKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQIS---------- 986
TG + P D R + G +T C G PVP++ W KD + +
Sbjct: 11 TGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW 70
Query: 987 -----KRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPI 1041
+ H ++ EG SLH D G Y+ A N G HL+V + P
Sbjct: 71 DLGWGQVGGH-RLLDEGQ---SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP- 125
Query: 1042 RSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPP 1101
S G QE ++ G L C SG+P
Sbjct: 126 ---------SVLGAGAAQE---------------------VLGLAGADVELQCWTSGVPT 155
Query: 1102 PELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLEL 1161
P++ W + QPVLP H + V+E G L I D G Y+C+A + GQ + +L
Sbjct: 156 PQVEWTKDRQPVLPGGPH-LQVQEDG-QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 213
Query: 1162 SVVAKEVKKAPVI--LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
V A P I + V E H V+L C G+P P W KD +P + + +
Sbjct: 214 RVHA-----PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
T G L + A+ SDAG YT A N G RLD+Y +PP ++
Sbjct: 269 Y----TRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY------VPP--TIEG 316
Query: 1280 SGSR 1283
+G R
Sbjct: 317 AGGR 320
Score = 99.0 bits (245), Expect = 3e-20
Identities = 87/319 (27%), Positives = 132/319 (41%), Gaps = 56/319 (17%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP+ TC + G+P P V W KD + H + R G L + G YT
Sbjct: 1857 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG----RLQLSRLQPAQAGTYT 1912
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N Q V ++ + R+ S+G + R H +
Sbjct: 1913 CVAENTQAEARKD---FVVAVLVAPRIRSSGVA--------------------REHHVL- 1948
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD-ASHKMLVRETGVHSLLIDPLT 1137
EG+ RLDC+ G PPP++ WL +G P+ D H + G SL++ L
Sbjct: 1949 -------EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLR 1999
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP---VRLECR 1194
DAG Y C+A N G+++ ++V+ P I + G P V + C
Sbjct: 2000 ASDAGAYTCVAHNPAGEDARLHTVNVLV-----PPTIKQGADGSGTLVSRPGELVTMVCP 2054
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
V G PP W KD +P + +R +H +G+ L I + +DAG +T A + AG+
Sbjct: 2055 VRGSPPIHVSWLKDGLPLPLS-QRTLLH--GSGHT-LRISKVQLADAGIFTCVAASPAGV 2110
Query: 1255 VSCTARLDIYAQWHHQIPP 1273
L + Q+PP
Sbjct: 2111 ADRNFTLQV------QVPP 2123
Score = 95.1 bits (235), Expect = 4e-19
Identities = 85/315 (26%), Positives = 127/315 (40%), Gaps = 48/315 (15%)
Query: 943 IAPIFDKRLKH-FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+AP+F R H V EG P +C+ G+P PK+ W KDG+ + E ++
Sbjct: 878 VAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLP--GEGAGLQHVSAVG 935
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER 1061
L++ +G YT +N G S L V P AG
Sbjct: 936 RLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP-----QIAGP----------- 979
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
+EP P + + + L+C +G PPP +TW +GQPV A +
Sbjct: 980 -REP-------------PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV--GAELGL 1023
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
++ G SL ++ G Y C+A N G+ ELSV+ L+ L N
Sbjct: 1024 QLQNQG-QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD--LDPLTNI 1080
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDT---TGYACLLIQPAKK 1238
P+ L C +G+PPP W + E +S +DT G L + ++
Sbjct: 1081 TAALHSPLTLLCEAMGIPPPAIRWFRGEEP-------VSPGEDTYLLAGGWMLKMTQTQE 1133
Query: 1239 SDAGWYTLSAKNEAG 1253
D+G Y+ A NEAG
Sbjct: 1134 QDSGLYSCLASNEAG 1148
Score = 94.0 bits (232), Expect = 9e-19
Identities = 85/300 (28%), Positives = 113/300 (37%), Gaps = 50/300 (16%)
Query: 954 FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDD 1013
F VT +PV TC GIP P V W K G Q+ R ++ G +L I
Sbjct: 2584 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG----ALEIGQALPIH 2639
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G YT A N G L VQ+ P+ L S ++
Sbjct: 2640 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA---------------------- 2677
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
VA E L L C+ SG+P P +TW G V S ++L L I
Sbjct: 2678 ---------VAEEEVL--LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG----QLRI 2722
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ DAG Y CIA N G L V + PVI L + EG L C
Sbjct: 2723 AHASPEDAGNYLCIAKNSAGSAMGKTRLVV-----QVPPVIENGLPDLSTTEGSHAFLPC 2777
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ G P P W KD + + + ++ LL++ + DAG YT +A+N G
Sbjct: 2778 KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE----LLVKNLEGQDAGTYTCTAENAVG 2833
Score = 93.6 bits (231), Expect = 1e-18
Identities = 92/360 (25%), Positives = 143/360 (39%), Gaps = 66/360 (18%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
SP+T C+ +GIP P + WF+ + +S + + G L + T D G Y+
Sbjct: 1086 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA----GGWMLKMTQTQEQDSGLYSC 1141
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
+A+N G + + V P ++ D E +
Sbjct: 1142 LASNEAGEARRNFSVEVLVPP----------------SIENEDLEEV------------- 1172
Query: 1080 GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
+ +G+ L C V+G P P+LTW +G+P+ +H + GV L +
Sbjct: 1173 --IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHH--ISPDGV-LLQVLQANLS 1227
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG-----VPEGHPVRLECR 1194
AG Y CIA N G+ + +LSV+ AP IL ++ V +P+ L C
Sbjct: 1228 SAGHYSCIAANAVGEKTKHFQLSVLL-----APTILGGAEDSADEEVTVTVNNPISLICE 1282
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
+ P P W KD +R I + T G L I A+K DAG YT NE G
Sbjct: 1283 ALAFPSPNITWMKDGAPFEASR-NIQLLPGTHG---LQILNAQKEDAGQYTCVVTNELG- 1337
Query: 1255 VSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSV 1314
+ +H ++ P PS S+ L G + + + ST+ C S +V
Sbjct: 1338 -------EAVKNYHVEVLIP----PSISKDDPLAEVG--VKEVKTKVNSTLTLECESWAV 1384
Score = 93.2 bits (230), Expect = 1e-18
Identities = 86/298 (28%), Positives = 119/298 (39%), Gaps = 46/298 (15%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V E + VT C G+P P V WFK + +S + DG L IE D G
Sbjct: 615 VLENASVTLECLASGVPPPDVSWFKGHQPVS---SWMGVTVSVDGRV-LRIEQAQLSDAG 670
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+Y +A+N G L V ++P R L +
Sbjct: 671 SYRCVASNVAGSTELRYGLRV-NVPPRITLPPS--------------------------- 702
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
PG ++ + RL C +G P P L WL +G PV P + + V G L +
Sbjct: 703 --LPGPVLVNTP--VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG-RVLTLAS 757
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
D+G Y C+A + G++ + L +V P IL + N V V LEC+
Sbjct: 758 ARASDSGRYSCVAVSAVGEDRQDVVL-----QVHMPPSILGEELNVSVVANESVALECQS 812
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
MPPPV W KD + R + + D A L + A DAG YT A N+AG
Sbjct: 813 HAMPPPVLSWWKDGRPLE-PRPGVHLSADK---ALLQVDRADVWDAGHYTCEALNQAG 866
Score = 91.3 bits (225), Expect = 6e-18
Identities = 77/303 (25%), Positives = 120/303 (39%), Gaps = 45/303 (14%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+V +G C + G P PK+ WFKDG+ +++ + H DG L +
Sbjct: 1174 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVL-LQVLQANLSSA 1229
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G+Y+ +AAN G + L V P G V P+
Sbjct: 1230 GHYSCIAANAVGEKTKHFQLSVLLAP----TILGGAEDSADEEVTVTVNNPIS------- 1278
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
L C+ P P +TW+ +G P + ++L G H L I
Sbjct: 1279 -----------------LICEALAFPSPNITWMKDGAPFEASRNIQLL---PGTHGLQIL 1318
Query: 1135 PLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ DAG Y C+ TN+ G+ ++ +E+ + K P+ ++ + LE
Sbjct: 1319 NAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLE 1378
Query: 1193 CRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLL-IQPAKKSDAGWYTLSAKN 1250
C +PPP W KD + + P +R ++ G LL IQP + SD+G Y A N
Sbjct: 1379 CESWAVPPPTIRWYKDGQPVTPSSRLQV------LGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 1251 EAG 1253
AG
Sbjct: 1433 VAG 1435
Score = 90.9 bits (224), Expect = 7e-18
Identities = 84/334 (25%), Positives = 147/334 (44%), Gaps = 41/334 (12%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+ + +K + S +T C+ +P P + W+KDG+ ++ + +++ G+G L
Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSS---RLQVLGEGRL-L 1413
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I+ T D G Y +A N G ++++Q P+ ++ + SR +E
Sbjct: 1414 QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 1473
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
+ R ++V E L C + +PPP+LTW QP+ A ++ V
Sbjct: 1474 VTEYR-----------EIV--ENNPAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVL 1518
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL----EKLQN 1180
+ G L I + +AG Y C A+N+ G++ EL V+ PVIL E ++
Sbjct: 1519 QGG-RVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT-----PPVILGDTEELVEE 1572
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKS 1239
V V L+C +G P P W ++ +P + R+ + +D L + A+ +
Sbjct: 1573 VTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDG---QVLQVSTAEVA 1627
Query: 1240 DAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
DA Y A+N+AG L + Q+PP
Sbjct: 1628 DAASYMCVAENQAGSAEKLFTLRV------QVPP 1655
Score = 88.6 bits (218), Expect = 4e-17
Identities = 98/399 (24%), Positives = 152/399 (38%), Gaps = 99/399 (24%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK-RNEHCKMRREGDGTCSLHIESTT 1010
+ V EG V C+ G P P V W KDG + + H + +G SL ++
Sbjct: 1943 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG---SLVLKGLR 1999
Query: 1011 SDDDGNYTIMAANPQGR-------------------------ISCSGHLMVQSLPIRS-- 1043
+ D G YT +A NP G +S G L+ P+R
Sbjct: 2000 ASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP 2059
Query: 1044 -----------------RLTSAGQSHRGR-SRVQERDK----------EPLQERFFRPHF 1075
R G H R S+VQ D + +R F
Sbjct: 2060 PIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV 2119
Query: 1076 LQAP--------GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P D+V G L L C+ G+P P ++W+ +G+P+L + E G
Sbjct: 2120 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS------LEQG 2173
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ--NCGVPE 1185
SL ++ + D+GTY C+A ++ G+ +L+V+ + P I + Q +
Sbjct: 2174 -PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM-----EPPHIEDSGQPTELSLTP 2227
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
G P+ L C G P P W KD + + R+ + T + + DAG YT
Sbjct: 2228 GAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRAT-------RVLRVRDAGLYT 2276
Query: 1246 LSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRY 1284
A++ AG + + R+ + A PP V P G R+
Sbjct: 2277 CLAESPAGAIEKSFRVRVQA-------PPNIVGPRGPRF 2308
Score = 87.4 bits (215), Expect = 8e-17
Identities = 85/328 (25%), Positives = 125/328 (38%), Gaps = 64/328 (19%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +PV TC G P P + W KDG +S G +L S + D G
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTL--ASARASDSG 764
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ +A + G R Q H S + E
Sbjct: 765 RYSCVAVSAVGE---------------DRQDVVLQVHMPPSILGE--------------- 794
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----- 1130
+ +VA+E L+C+ +PPP L+W +G+P+ P GVH
Sbjct: 795 -ELNVSVVANES--VALECQSHAMPPPVLSWWKDGRPLEP---------RPGVHLSADKA 842
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI-LEKLQNCGVPEGHP 1188
L +D DAG Y C A N+ G + L+V APV L + V EGHP
Sbjct: 843 LLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV-----APVFPLRESHTLTVREGHP 897
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
RL C G+P P W+KD + +P E + + L + A+ + G YT
Sbjct: 898 TRLSCECRGVPFPKISWRKDGQPLP--GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 955
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
N G S +L+++ +PP ++
Sbjct: 956 SNVVGNSSQDLQLEVH------VPPQIA 977
Score = 87.4 bits (215), Expect = 8e-17
Identities = 79/300 (26%), Positives = 116/300 (38%), Gaps = 58/300 (19%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+T G+P+ C G P P + W KDG+ +++ + + R L + D G
Sbjct: 2225 LTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV------LRVR-----DAG 2273
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT +A +P G I S + VQ+ P + V R P F
Sbjct: 2274 LYTCLAESPAGAIEKSFRVRVQAPP---------------NIVGPRG----------PRF 2308
Query: 1076 LQ--APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
+ APG +V L+C V P P++TW +G + DA + R L +
Sbjct: 2309 VVGLAPGQLV--------LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG---RFLQL 2357
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
L+ D+G Y C A N G S + + E+ P I V L C
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRV-----EIHTVPTIRSGPPAVNVSVNQTALLPC 2412
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ G+P P+ W+KD + R + + L IQP DAG Y A N AG
Sbjct: 2413 QADGVPAPLVSWRKDRVPLDPRSPRFEILPE----GSLRIQPVLAQDAGHYLCLASNSAG 2468
Score = 82.8 bits (203), Expect = 2e-15
Identities = 82/340 (24%), Positives = 137/340 (40%), Gaps = 57/340 (16%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G+ V C G+P P+V W KD + + H +++ +G L I + D+G Y
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ---VLRITGSHVGDEGRYQ 197
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A +P G+ + L V + P T G +
Sbjct: 198 CVAFSPAGQQARDFQLRVHAPP-----TIWGSNE-------------------------- 226
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
G++ E L +L C+ G+P P +TW +G +LP ++ + R G L +
Sbjct: 227 TGEVAVMEDHLVQLLCEARGVPTPNITWFKDG-ALLPTSTKVVYTR--GGRQLQLGRAQS 283
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKA---PVILEKLQNCGVPEGHPVRLECR 1194
DAG Y C A+N G + L V V ++ A P +++ + G PV LEC
Sbjct: 284 SDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV------AGRPVALECV 337
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G P P W +E +P S +T G L P + S +G Y+ A + AG
Sbjct: 338 ARGHPSPTLSW--HHEGLPVAESNES-RLETDGSVLRLESPGEAS-SGLYSCVASSPAGE 393
Query: 1255 VSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDI 1294
+++ Q+PP + V + ++ + L++
Sbjct: 394 AVLQYSVEV------QVPPQLLVAEGLGQVTTIVGQPLEL 427
Score = 82.8 bits (203), Expect = 2e-15
Identities = 74/312 (23%), Positives = 116/312 (37%), Gaps = 44/312 (14%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V E V C+ G+P P + WFKDG + + R G L + S D G
Sbjct: 232 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR----GGRQLQLGRAQSSDAG 287
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT A+N G + L V P + AG RP+
Sbjct: 288 VYTCKASNAVGAAEKATRLDVYVPP---TIEGAGG---------------------RPYV 323
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++A GR L+C G P P L+W G PV ++ ET L ++
Sbjct: 324 VKAVA------GRPVALECVARGHPSPTLSWHHEGLPVAESNESRL---ETDGSVLRLES 374
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
+ +G Y C+A++ G+ + V +V ++ E L G P+ L C+
Sbjct: 375 PGEASSGLYSCVASSPAGEAVLQYSVEV---QVPPQLLVAEGLGQVTTIVGQPLELPCQA 431
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G P P W ++ E ++ Q + L I + +G + A NEAG
Sbjct: 432 SGSPVPTIQWLQNGR----PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 487
Query: 1256 SCTARLDIYAQW 1267
+ ++ +W
Sbjct: 488 GAEVEVSVHGEW 499
Score = 75.1 bits (183), Expect = 4e-13
Identities = 81/342 (23%), Positives = 130/342 (38%), Gaps = 62/342 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+ E +P C IP P + W+++ + +S +E ++ G L I +++ G
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ----GGRVLQIPLVRAENAG 1535
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ A+N G L+V + P+ D E L E
Sbjct: 1536 RYSCKASNEVGEDWLHYELLVLTPPVILG-----------------DTEELVE------- 1571
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++ + L C G P P ++WL NG P P S ++ V E G L +
Sbjct: 1572 -----EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDG-QVLQVST 1623
Query: 1136 LTQRDAGTYKCIATNKTG--QNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPV 1189
DA +Y C+A N+ G + F+L + V + ++++ IL V
Sbjct: 1624 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS----------SV 1673
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
L C V P P W KD++ + E + G L + A+ SD+G YT A
Sbjct: 1674 SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL----PGTHTLQLGRARLSDSGMYTCEAL 1729
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKG 1291
N AG +L + +PP P G + L G
Sbjct: 1730 NAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVG 1765
Score = 74.3 bits (181), Expect = 7e-13
Identities = 71/292 (24%), Positives = 115/292 (39%), Gaps = 53/292 (18%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C+ G+P P V W KD + R+ ++ EG SL I+ + D G+Y +A+N
Sbjct: 2412 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG----SLRIQPVLAQDAGHYLCLASN-- 2465
Query: 1026 GRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAH 1085
SAG +GR R EP P +P ++
Sbjct: 2466 ---------------------SAGSDRQGRDL---RVLEP-------PAIAPSPSNLTLT 2494
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPV---LPDASHKMLVRETGVHSLLIDPLTQRDAG 1142
L C+ SG P P + W +GQ + L ++++L ++LL+ +D+
Sbjct: 2495 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS----NALLLTAPGPQDSA 2550
Query: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
++C+ +N+ G+ +++ V P I + + V PV L C G+P P
Sbjct: 2551 QFECVVSNEVGEAHRLYQVT-----VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT 2605
Query: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
W K + + L I A AG YT SA+N AG+
Sbjct: 2606 VSWSKAGAQLGARGSGYRVSPS----GALEIGQALPIHAGRYTCSARNSAGV 2653
Score = 73.9 bits (180), Expect = 9e-13
Identities = 76/292 (26%), Positives = 109/292 (37%), Gaps = 46/292 (15%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
S V+ C + P P+V W+KD + +S E + GT +L + D G YT
Sbjct: 1671 SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL----PGTHTLQLGRARLSDSGMYTC 1726
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
A N GR L V P + Q+ RG P
Sbjct: 1727 EALNAAGRDQKLVQLSVLVPP------AFRQAPRG------------------------P 1756
Query: 1080 GDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
D V G L C+ LP P +TW +GQP++ + L G L I
Sbjct: 1757 QDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQAL---RGGQRLEIQEAQV 1813
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
D G Y C +N G+ + L+V + P K + G P+ L C V G+
Sbjct: 1814 SDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCDVSGV 1869
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
P P W KD + E ++H + L + + + AG YT A+N
Sbjct: 1870 PAPTVTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 1917
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/289 (22%), Positives = 114/289 (39%), Gaps = 49/289 (16%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C + P PK+ W +DG + + + H + G L +++ ++ D G+Y+ A N
Sbjct: 2321 CSVEAEPAPKITWHRDGI-VLQEDAHTQFPERGR---FLQLQALSTADSGDYSCTARNAA 2376
Query: 1026 GRISCSGHLMVQSLP-IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA 1084
G S + + + ++P IRS P +
Sbjct: 2377 GSTSVAFRVEIHTVPTIRS----------------------------------GPPAVNV 2402
Query: 1085 HEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTY 1144
+ L C+ G+P P ++W + P+ P + ++ E SL I P+ +DAG Y
Sbjct: 2403 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHY 2459
Query: 1145 KCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFY 1204
C+A+N G + +L V+ + P I N + P L C G P P+
Sbjct: 2460 LCLASNSAGSDRQGRDLRVL-----EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVV 2514
Query: 1205 WKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
W KD + + R + ++ A LL P + D+ + NE G
Sbjct: 2515 WWKDGQKLD-FRLQQGAYRLLPSNALLLTAPGPQ-DSAQFECVVSNEVG 2561
Score = 73.2 bits (178), Expect = 2e-12
Identities = 80/328 (24%), Positives = 125/328 (38%), Gaps = 67/328 (20%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V GS V C+ G+P+P V W KDG+ + ++ +G SL +E+ + D G
Sbjct: 2136 VVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS-----LEQGP---SLQLEAVGAGDSG 2187
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ +A + G L V P + +GQ
Sbjct: 2188 TYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQ------------------------- 2219
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
P ++ G L C G P P +TW +GQ + ++ R V
Sbjct: 2220 ---PTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV------- 2269
Query: 1136 LTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLE 1192
RDAG Y C+A + G + SF + + V + P + G+ G V LE
Sbjct: 2270 ---RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFV-----VGLAPGQLV-LE 2320
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C V P P W +D + + + Q L +Q +D+G Y+ +A+N A
Sbjct: 2321 CSVEAEPAPKITWHRDGIVL----QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 2376
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
G S R++I H +P S P+
Sbjct: 2377 GSTSVAFRVEI-----HTVPTIRSGPPA 2399
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/195 (28%), Positives = 78/195 (40%), Gaps = 42/195 (21%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G + C + G PVP ++W KDG + R H + + + SL I T DD G Y
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPL--RGSHLRHQLQNG---SLTIRRTERDDAGRYQ 3005
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N G L++QS P+ F
Sbjct: 3006 CLAENEMGVAKKVVILVLQSAPV---------------------------------FQVE 3032
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
P DM G L C+ +G P P + WL GQP+ AS ++ G SL ++ +
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL--RASRRLRTLPDG--SLWLENVET 3088
Query: 1139 RDAGTYKCIATNKTG 1153
DAGTY C+A N G
Sbjct: 3089 GDAGTYDCVAHNLLG 3103
Score = 69.7 bits (169), Expect = 2e-11
Identities = 67/278 (24%), Positives = 111/278 (39%), Gaps = 35/278 (12%)
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
RE+ E L C IPPP + WY E + L ++ ++Q G + + + A E+ G
Sbjct: 1478 REIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRA--ENAG 1535
Query: 338 RYSCFASNIYGTDSTSAEIYI--EGVSSSDSEGDPNKEEMN-----RIQKPNEVSSPPTT 390
RYSC ASN G D E+ + V D+E + +N +Q P + PT
Sbjct: 1536 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTI 1595
Query: 391 SAV---IPPAVPQAQHLVAQPRVATIQQCQ--SPTNYLQGLDGKPIIAAPVFTKM----- 440
S + +P + ++ +V + + +Y+ + + A +FT
Sbjct: 1596 SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPP 1655
Query: 441 ------LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
L+ ++A V C V P+P+V WY++ + + +L
Sbjct: 1656 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH------ 1709
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
TL + DSG +TC A N G + QL V
Sbjct: 1710 ----TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 1743
Score = 68.9 bits (167), Expect = 3e-11
Identities = 58/201 (28%), Positives = 80/201 (39%), Gaps = 15/201 (7%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P+ P + E L+C SG+PPP+++W QPV +S + L
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPV---SSWMGVTVSVDGRVLR 660
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I+ DAG+Y+C+A+N G L V P L V PVRL
Sbjct: 661 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG----PVLVNTPVRLT 716
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C G P P W KD P + Q G L + A+ SD+G Y+ A +
Sbjct: 717 CNATGAPSPTLMWLKDGN--PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 774
Query: 1253 GIVSCTARLDIYAQWHHQIPP 1273
G R D+ Q H +PP
Sbjct: 775 G----EDRQDVVLQVH--MPP 789
Score = 68.6 bits (166), Expect = 4e-11
Identities = 83/325 (25%), Positives = 121/325 (37%), Gaps = 47/325 (14%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G P+ C+ G PVP + W ++G+ E ++ GT +LHI+ D G +
Sbjct: 422 GQPLELPCQASGSPVPTIQWLQNGRPAE---ELAGVQVASQGT-TLHIDHVELDHSGLFA 477
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRL-TSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
A N G + V L GQ H G
Sbjct: 478 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSS---------------FP 522
Query: 1078 APGDMVAHEGRLCRLDCK-VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPL 1136
A D H G V G P W G+P ++ + L I+ +
Sbjct: 523 AACDPPVHRGWGAHPKPPLVEGWCSPGSLW---GEPTGIPVAYSL------PPPLQIEKV 573
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
RD G Y C ATN G++ + L V V ++ PV N V E V LEC
Sbjct: 574 DLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV------NKAVLENASVTLECLA 627
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G+PPP W K ++ + + +++ D L I+ A+ SDAG Y A N AG
Sbjct: 628 SGVPPPDVSWFKGHQPV-SSWMGVTVSVDG---RVLRIEQAQLSDAGSYRCVASNVAGST 683
Query: 1256 SCTARLDIYAQWHHQIPPPMSVRPS 1280
L + +PP +++ PS
Sbjct: 684 ELRYGLRV------NVPPRITLPPS 702
Score = 68.6 bits (166), Expect = 4e-11
Identities = 66/320 (20%), Positives = 124/320 (38%), Gaps = 59/320 (18%)
Query: 256 PSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI 315
P S+ ++PL + ++ + + + L+C +PPP +RWY +G+ + S +
Sbjct: 1350 PPSISKDDPLAEVG-----VKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 1404
Query: 316 HIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE---------------G 360
++ G L L I D+GRY C A+N+ G D + I+
Sbjct: 1405 QVLGEGRL--LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFE 1462
Query: 361 VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVP---QAQHLVAQPRVATIQ--- 414
+ S + E E I + N T+A+ PP + + Q L A V+ +Q
Sbjct: 1463 ILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGR 1522
Query: 415 ---------------QCQSPTN------YLQGLDGKPIIAAPVFTKMLQNLSASEGQLVV 453
C++ + + L P + ++++ ++ + V
Sbjct: 1523 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVS 1582
Query: 454 FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
+C G P P + W + G SP ++L E ++ + AEV D+ +
Sbjct: 1583 LQCPALGNPVPTISWLQNGLPFSPSPRLQVL--------EDGQVLQVSTAEV--ADAASY 1632
Query: 514 TCTASNKYGTVSSIAQLHVR 533
C A N+ G+ + L V+
Sbjct: 1633 MCVAENQAGSAEKLFTLRVQ 1652
Score = 67.4 bits (163), Expect = 9e-11
Identities = 87/376 (23%), Positives = 134/376 (35%), Gaps = 63/376 (16%)
Query: 948 DKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIE 1007
++ ++ V S V+ C +G PVP + W ++G S + ++ +G L +
Sbjct: 1567 EELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP-SPRLQVLEDGQ---VLQVS 1622
Query: 1008 STTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQ 1067
+ D +Y +A N G L VQ P R+ D E
Sbjct: 1623 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPP----------------RIAGLDLE--- 1663
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
+ A L C V P PE+TW + Q + +L G
Sbjct: 1664 -------------QVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL---PG 1707
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAP-----VILEKLQNC 1181
H+L + D+G Y C A N G++ ++LSV V ++AP +L ++
Sbjct: 1708 THTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV--- 1764
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
G L C +P P W KD + + + Q G L IQ A+ SD
Sbjct: 1765 ----GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT----QALRGGQRLEIQEAQVSDK 1816
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSM 1301
G Y+ N AG T L + Q+PP P + L + S +
Sbjct: 1817 GLYSCKVSNVAGEAVRTFTLTV------QVPPTFE-NPKTETVSQVAGSPLVLTCDVSGV 1869
Query: 1302 ESTMVYSCSSRSVVES 1317
+ V R VES
Sbjct: 1870 PAPTVTWLKDRMPVES 1885
Score = 67.4 bits (163), Expect = 9e-11
Identities = 65/268 (24%), Positives = 103/268 (38%), Gaps = 37/268 (13%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
V L C GIP P + W EG + ++ G L IA A ED G Y C A N
Sbjct: 2683 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLR---IAHASPEDAGNYLCIAKN 2739
Query: 346 IYGTDSTSAEIYIE-------GVSS-SDSEGD----PNKEEMNRIQKPN--------EVS 385
G+ + ++ G+ S +EG P K + +PN VS
Sbjct: 2740 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGS--PEPNITWDKDGQPVS 2797
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLS 445
+ P ++L Q ++ + I+ PVFT + + S
Sbjct: 2798 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRS 2857
Query: 446 ASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEV 505
G + C +G+P+P++ W + D P ++E + TL A V
Sbjct: 2858 LRLGDRLWLRCAARGSPTPRIGW-----TVNDRP-------VTEGVSEQDGGSTLQRAAV 2905
Query: 506 FAEDSGCFTCTASNKYGTVSSIAQLHVR 533
EDSG + C A N+ G +++ +HV+
Sbjct: 2906 SREDSGTYVCWAENRVGRTQAVSFVHVK 2933
Score = 64.7 bits (156), Expect = 6e-10
Identities = 59/222 (26%), Positives = 90/222 (40%), Gaps = 41/222 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+ G PV C G P P + W +G +++ NE R E DG+ L +ES
Sbjct: 325 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES---RLETDGSV-LRLESPGEASS 380
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G Y+ +A++P G + VQ P L + G
Sbjct: 381 GLYSCVASSPAGEAVLQYSVEVQVPP--QLLVAEGL------------------------ 414
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
G + G+ L C+ SG P P + WL NG+P A ++ + T +H ID
Sbjct: 415 -----GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLH---ID 466
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILE 1176
+ +G + C ATN+ G +E+SV + AP +LE
Sbjct: 467 HVELDHSGLFACQATNEAGTAGAEVEVSV---HGEWAPGVLE 505
Score = 63.9 bits (154), Expect = 1e-09
Identities = 78/329 (23%), Positives = 115/329 (34%), Gaps = 55/329 (16%)
Query: 239 EQAASEAAGGDTTPGSS---PSSLYYEEPLGQPPRFT-QKLRSREVPEGTRVQLDCIVVG 294
EQA AG S+ + L Y + PPR T V T V+L C G
Sbjct: 662 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATG 721
Query: 295 IPPPQVRWYCEGKELE--NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P + W +G + +P + + G + LT+A A D+GRYSC A + G D
Sbjct: 722 APSPTLMWLKDGNPVSPAGTPGLQVFPGGRV--LTLASARASDSGRYSCVAVSAVGEDRQ 779
Query: 353 SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAV------------PQ 400
+ + S EE+N NE + S +PP V
Sbjct: 780 DVVLQVHMPPSILG------EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP 833
Query: 401 AQHLVAQPRVATIQQCQ------------SPTNYLQGLDGKPIIAAPVF-TKMLQNLSAS 447
HL A + + + + + + + APVF + L+
Sbjct: 834 GVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVR 893
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT----LVIA 503
EG C +G P PK+ W ++G Q P A + + L +
Sbjct: 894 EGHPTRLSCECRGVPFPKISWRKDG------------QPLPGEGAGLQHVSAVGRLLYLG 941
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ G +TC SN G S QL V
Sbjct: 942 QAQLAQEGTYTCECSNVVGNSSQDLQLEV 970
Score = 62.4 bits (150), Expect = 3e-09
Identities = 72/341 (21%), Positives = 129/341 (37%), Gaps = 50/341 (14%)
Query: 208 RSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQ 267
+ +P+P+ T + H L + + +A AA + + P+ +
Sbjct: 2067 KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2126
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK-----ELENSPDIHIVQAGN 322
P F + V G+ V+L C G+P P V W +G+ LE P + + G
Sbjct: 2127 PVEFQNDV---VVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVG- 2182
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK------EEMN 376
D+G YSC A + G ++ + + G P + M
Sbjct: 2183 ----------AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPME 2232
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQC-------QSPTNYLQG---- 425
+ P T A+ + ++ RV ++ +SP ++
Sbjct: 2233 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2292
Query: 426 -LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P I P + + L+ GQLV+ EC V+ P+PK+ W+R+G ++++ +
Sbjct: 2293 RVQAPPNIVGPRGPRFVVGLAP--GQLVL-ECSVEAEPAPKITWHRDGIVLQEDAHTQF- 2348
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
PE L + + DSG ++CTA N G+ S
Sbjct: 2349 ---------PERGRFLQLQALSTADSGDYSCTARNAAGSTS 2380
Score = 62.0 bits (149), Expect = 4e-09
Identities = 70/286 (24%), Positives = 109/286 (38%), Gaps = 51/286 (17%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V E VQL C G+P P + W+ +G L S + + G L + A D G Y
Sbjct: 232 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG--RQLQLGRAQSSDAGVY 289
Query: 340 SCFASNIYGT--DSTSAEIY----IEGVSS-----SDSEGDPNKEEMNRIQKPNEVSSPP 388
+C ASN G +T ++Y IEG G P E P+ P
Sbjct: 290 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS-----P 344
Query: 389 TTS---AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--------DGKPIIAAPVF 437
T S +P A L ++ + +SP GL G+ ++ V
Sbjct: 345 TLSWHHEGLPVAESNESRLETD---GSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 401
Query: 438 TKMLQNLSASE---------GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
++ L +E GQ + C+ G+P P ++W + G E+ ++ +
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG- 460
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
TL I V + SG F C A+N+ GT + ++ V G
Sbjct: 461 ---------TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 497
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/298 (22%), Positives = 107/298 (35%), Gaps = 53/298 (17%)
Query: 276 RSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEED 335
R V EG V+LDC G PPP V W +G L H+ + SL + D
Sbjct: 1943 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2002
Query: 336 TGRYSCFASNIYGTDST--SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV--------S 385
G Y+C A N G D+ + + + ++G + +P E+
Sbjct: 2003 AGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG-----TLVSRPGELVTMVCPVRG 2057
Query: 386 SPPTTSAVIPPAVP----QAQHLVAQPRVATIQQCQ------------SPT-----NYLQ 424
SPP + + +P Q L I + Q SP N+
Sbjct: 2058 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2117
Query: 425 GLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P++ F ++ G LV C +G P P V W ++G
Sbjct: 2118 QVQVPPVLEPVEFQ---NDVVVVRGSLVELPCEARGVPLPLVSWMKDG------------ 2162
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+P E+ +L + V A DSG ++C A ++ G QL V + ++G
Sbjct: 2163 --EPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2218
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 37/286 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT R + G R+ L C G P P++ W + + + + +L
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG----VSEQDGGSTLQR 2902
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEM--NRIQKPNEVSS 386
A ED+G Y C+A N G + ++++ E E IQ V
Sbjct: 2903 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG 2962
Query: 387 PPTTSAV-IPPAVP-QAQHLVAQPRVATIQ------------QCQSPTNYLQGLDGKPII 432
P I +P + HL Q + ++ QC + G+ K +I
Sbjct: 2963 DPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENE--MGVAKKVVI 3020
Query: 433 ----AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+APVF Q+++ G V C+ G P+P +EW + G + S R L
Sbjct: 3021 LVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG- 3079
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+L + V D+G + C A N G+ ++ A L VRG
Sbjct: 3080 ----------SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115
Score = 60.1 bits (144), Expect = 1e-08
Identities = 68/295 (23%), Positives = 115/295 (38%), Gaps = 45/295 (15%)
Query: 268 PPRFTQKLRSRE----VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PP F Q R + V G + L C +P P V WY +G+ L + ++ G
Sbjct: 1746 PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGG-- 1803
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
L I EA D G YSC SN+ G + + V + +P E ++++
Sbjct: 1804 QRLEIQEAQVSDKGLYSCKVSNVAG---EAVRTFTLTVQVPPTFENPKTETVSQVAGSPL 1860
Query: 384 VSSPPTTSAVIP---------PAVPQAQHLV----AQPRVATIQQCQSPT-----NYLQG 425
V + + P P A H V + +++ +Q Q+ T Q
Sbjct: 1861 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 1920
Query: 426 LDGKPIIAAPVFTKMLQNLSAS------EGQLVVFECRVKGAPSPKVEWYREGTLI--ED 477
K + A + +++ + EGQ V +C G P P V W ++G+ + +
Sbjct: 1921 EARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDM 1980
Query: 478 SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
P R + +LV+ + A D+G +TC A N G + + ++V
Sbjct: 1981 GPHLRFYL----------DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 2025
Score = 58.2 bits (139), Expect = 5e-08
Identities = 63/277 (22%), Positives = 107/277 (38%), Gaps = 62/277 (22%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKE-LENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
G V+L C G+P PQV W + + L P + + + G + L I + D GRY C
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV--LRITGSHVGDEGRYQC 198
Query: 342 FASNIYGTDSTSAEIYIEG---VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS------- 391
A + G + ++ + + S+ G+ E + +Q E PT +
Sbjct: 199 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 258
Query: 392 AVIPPAVP--------QAQHLVAQPRVATIQQCQS------------------PTNYLQG 425
A++P + Q Q AQ A + C++ PT ++G
Sbjct: 259 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT--IEG 316
Query: 426 LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQ 485
G+P + + A G+ V EC +G PSP + W+ EG + +S + R+
Sbjct: 317 AGGRPYV-----------VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL-- 363
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ L + SG ++C AS+ G
Sbjct: 364 --------ETDGSVLRLESPGEASSGLYSCVASSPAG 392
Score = 56.6 bits (135), Expect = 2e-07
Identities = 55/276 (19%), Positives = 99/276 (35%), Gaps = 33/276 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP ++ V E V L+C+ G+PPP V W+ + + + + + G + L
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV--LR 660
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE---------GVSSSDSEGDPNKEEMNRI 378
I +A D G Y C ASN+ G+ + + + P + N
Sbjct: 661 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 720
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTN--------YLQGLDGKP 430
P+ + PA + RV T+ ++ + G D +
Sbjct: 721 GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD 780
Query: 431 II----AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
++ P N+S + V EC+ P P + W+++G +E P +
Sbjct: 781 VVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD 840
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
K + ++ D+G +TC A N+ G
Sbjct: 841 KALLQVDRADVW----------DAGHYTCEALNQAG 866
Score = 56.6 bits (135), Expect = 2e-07
Identities = 59/264 (22%), Positives = 98/264 (37%), Gaps = 30/264 (11%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C V P P++ W+ +G L+ + G L + D+G YSC A N
Sbjct: 2319 LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF--LQLQALSTADSGDYSCTARNAA 2376
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK--------PNEVSSPPTTSAVIPPAVP 399
G+ S + + I V + S +N+ P + S + P P
Sbjct: 2377 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 2436
Query: 400 QAQHLVAQPRVATIQQCQSPTNYL-----------QGLDGKPIIAAPVFTKMLQNLSASE 448
+ + L Q +YL QG D + ++ P NL+ +
Sbjct: 2437 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR-VLEPPAIAPSPSNLTLTA 2495
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C G+P P V W+++G + DFR+ Q R + L++ +
Sbjct: 2496 HTPALLPCEASGSPKPLVVWWKDGQKL----DFRLQQGAYRLLPSN----ALLLTAPGPQ 2547
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
DS F C SN+ G + Q+ V
Sbjct: 2548 DSAQFECVVSNEVGEAHRLYQVTV 2571
Score = 56.2 bits (134), Expect = 2e-07
Identities = 59/274 (21%), Positives = 103/274 (37%), Gaps = 42/274 (15%)
Query: 279 EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGR 338
+V +G L C V G P P++ W+ +G+ L HI G L L + +A G
Sbjct: 1174 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL--LQVLQANLSSAGH 1231
Query: 339 YSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVS---------SPPT 389
YSC A+N G + ++ + + + + +E + N +S SP
Sbjct: 1232 YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI 1291
Query: 390 T------------SAVIPPAVPQAQHLVAQPR-------VATIQQCQSPTNYLQGLDGKP 430
T + + P Q L AQ V T + ++ NY + P
Sbjct: 1292 TWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1351
Query: 431 IIAA--PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
I+ P+ ++ + + EC P P + WY++G + S ++L +
Sbjct: 1352 SISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1411
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+P ++ DSG + C A+N G
Sbjct: 1412 LLQIQPTQV----------SDSGRYLCVATNVAG 1435
Score = 53.5 bits (127), Expect = 1e-06
Identities = 57/268 (21%), Positives = 100/268 (37%), Gaps = 35/268 (13%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C G PPP V W +G+ + + + G SL + A TGRYSC A N+
Sbjct: 996 LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ--SLHVERAQAAHTGRYSCVAENLA 1053
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP-----NEVSSPPTT----SAVIPPAV 398
G E+ + + DP + P + PP P +
Sbjct: 1054 GRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1113
Query: 399 PQAQHLVAQPRVATIQQCQSPTNYL-------------QGLDGKPIIAAPVFTKMLQN-L 444
+ +L+A + + Q Q + L + + ++ + + L+ +
Sbjct: 1114 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVI 1173
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
+GQ C V G P PK+ W+++G R L + P+ + L + +
Sbjct: 1174 KVLDGQTAHLMCNVTGHPQPKLTWFKDG---------RPLARGDAHHISPDGV-LLQVLQ 1223
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+G ++C A+N G + QL V
Sbjct: 1224 ANLSSAGHYSCIAANAVGEKTKHFQLSV 1251
Score = 50.4 bits (119), Expect = 1e-05
Identities = 60/271 (22%), Positives = 106/271 (39%), Gaps = 45/271 (16%)
Query: 290 CIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
C +GIPPP +RW+ + + D +++ G + L + + E+D+G YSC ASN G
Sbjct: 1092 CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM--LKMTQTQEQDSGLYSCLASNEAGE 1149
Query: 350 DSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN------EVSSPPTTSAV-----IPPAV 398
+ + + S ++E + EE+ ++ V+ P P A
Sbjct: 1150 ARRNFSVEVLVPPSIENE---DLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1206
Query: 399 PQAQHL--------VAQPRVATIQQCQSPTNYLQGLDGK----PIIAAPVFTKMLQNLSA 446
A H+ V Q +++ G K ++ AP ++ +
Sbjct: 1207 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1266
Query: 447 SEGQLVV-----FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
E + V C PSP + W ++G E S + ++L P + L
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLL---PGTHG-------LQ 1316
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
I ED+G +TC +N+ G ++ HV
Sbjct: 1317 ILNAQKEDAGQYTCVVTNELG--EAVKNYHV 1345
Score = 50.4 bits (119), Expect = 1e-05
Identities = 72/319 (22%), Positives = 107/319 (33%), Gaps = 56/319 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+T +P C+ G P P V W+KDG+++ R + R +L + + D
Sbjct: 2493 LTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN--ALLLTAPGPQDSA 2550
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+ + +N G++HR Q P P
Sbjct: 2551 QFECVVSN-----------------------EVGEAHR---LYQVTVHVP-------PTI 2577
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
D L C +G+P P ++W G + S R + +L I
Sbjct: 2578 ADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG---YRVSPSGALEIGQ 2634
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLECR 1194
AG Y C A N G + L+V A V K P ++ + V L C
Sbjct: 2635 ALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE------EEVLLPCE 2688
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G+P P W+K+ + + L I A DAG Y AKN AG
Sbjct: 2689 ASGIPRPTITWQKEGLNVAT-----GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Query: 1255 VSCTARLDIYAQWHHQIPP 1273
RL + Q+PP
Sbjct: 2744 AMGKTRLVV------QVPP 2756
Score = 48.9 bits (115), Expect = 3e-05
Identities = 60/274 (21%), Positives = 102/274 (37%), Gaps = 48/274 (17%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V EG +L C G+P P++ W +G+ L E + H+ G L L A+ +E G
Sbjct: 892 VREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--G 949
Query: 338 RYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-----------EMNRIQKPNEVSS 386
Y+C SN+ G S ++ + +P + E N KP
Sbjct: 950 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP----- 1004
Query: 387 PPTTS---AVIPPAVPQAQHLVAQPRVATIQQCQSP-----TNYLQGLDGK-------PI 431
PPT + P L Q + +++ Q+ + + L G+ +
Sbjct: 1005 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV 1064
Query: 432 IAAPVF---TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+ P L N++A+ + C G P P + W+R + D +L
Sbjct: 1065 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG- 1123
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
L + + +DSG ++C ASN+ G
Sbjct: 1124 ---------WMLKMTQTQEQDSGLYSCLASNEAG 1148
Score = 45.4 bits (106), Expect = 4e-04
Identities = 67/307 (21%), Positives = 109/307 (35%), Gaps = 56/307 (18%)
Query: 268 PPRFTQKLRSREVP--EGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--------DIHI 317
PP + R V G + L+C G P P++ W + +L P D+
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA-QLVGVPLGWAGYGWDLGW 74
Query: 318 VQAGNLHSLTIAEAF------EEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPN 371
Q G L ++ E D+G YSC A N GT + + ++ G
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV--LTPPSVLGAGA 132
Query: 372 KEEMNRIQKPNEVSSPPTTSAVIP---------PAVPQAQHLVAQPRVATIQ-------- 414
+E+ + + T+ P P +P HL Q ++
Sbjct: 133 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 192
Query: 415 ----QCQ--SPTNYLQGLDGKPIIAAPVF---TKMLQNLSASEGQLVVFECRVKGAPSPK 465
QC SP Q D + + AP + ++ E LV C +G P+P
Sbjct: 193 EGRYQCVAFSPAGQ-QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN 251
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ W+++G L+ S + + R L + + D+G +TC ASN G
Sbjct: 252 ITWFKDGALLPTSTKV-VYTRGGRQ---------LQLGRAQSSDAGVYTCKASNAVGAAE 301
Query: 526 SIAQLHV 532
+L V
Sbjct: 302 KATRLDV 308
Score = 45.1 bits (105), Expect = 5e-04
Identities = 75/351 (21%), Positives = 116/351 (33%), Gaps = 75/351 (21%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSS---LYYEEPLGQPPRF--TQKLRS 277
E N + + + E ++G + SSP+ L Y + PP+ + L
Sbjct: 357 ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ 416
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
G ++L C G P P ++W G+ E + + G +L I + +G
Sbjct: 417 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSG 474
Query: 338 RYSCFASNIYGTDSTSAEIYIEGV--------------------SSSDSEGDPNKEE--- 374
++C A+N GT E+ + G SS + DP
Sbjct: 475 LFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 534
Query: 375 -------MNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNY----- 422
+ P + PT V P Q R I C + TN
Sbjct: 535 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTC-AATNLAGESK 593
Query: 423 ----LQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIED- 477
L+ L I PV +L+N S V EC G P P V W++ +
Sbjct: 594 REVALKVLVPPNIEPGPVNKAVLENAS------VTLECLASGVPPPDVSWFKGHQPVSSW 647
Query: 478 -----SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
S D R+L+ I + D+G + C ASN G+
Sbjct: 648 MGVTVSVDGRVLR----------------IEQAQLSDAGSYRCVASNVAGS 682
Score = 45.1 bits (105), Expect = 5e-04
Identities = 55/290 (18%), Positives = 101/290 (34%), Gaps = 50/290 (17%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L EG+ L C G P P + W +G+ + + +Q L
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG--ELL 2812
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS-SSDSEGDPNKEEMNRIQKPNEVSS 386
+ +D G Y+C A N G + I + + GD + +R+
Sbjct: 2813 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARG 2872
Query: 387 PPTTSAVIPPAV-------PQAQHLVAQPRVATIQQC----QSPTNYLQGLDGK------ 429
PT P + P + + Q +T+Q+ + Y+ + +
Sbjct: 2873 SPT------PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 2926
Query: 430 ---------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
P++ F+ +++ + S + +C V+G P P + W ++G + S
Sbjct: 2927 VSFVHVKEAPVLQGEAFSYLVEPVGGS----IQLDCVVRGDPVPDIHWIKDGLPLRGSHL 2982
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
LQ +L I +D+G + C A N+ G + L
Sbjct: 2983 RHQLQNG-----------SLTIRRTERDDAGRYQCLAENEMGVAKKVVIL 3021
Score = 44.3 bits (103), Expect = 8e-04
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP+F + V G V C+ G P P + W + G+ + ++R DG S
Sbjct: 3026 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASR---RLRTLPDG--S 3080
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L +E+ + D G Y +A N G + L+V+ P
Sbjct: 3081 LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 42.0 bits (97), Expect = 0.004
Identities = 27/96 (28%), Positives = 39/96 (40%), Gaps = 3/96 (3%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L P F + + V G V L C G P P + W G+ L S + + G
Sbjct: 3023 LQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG--- 3079
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
SL + D G Y C A N+ G+ + A + + G
Sbjct: 3080 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3115
Score = 40.8 bits (94), Expect = 0.009
Identities = 70/319 (21%), Positives = 106/319 (33%), Gaps = 44/319 (13%)
Query: 240 QAASEAAGGDTT----PGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
QA S A GD + + +S+ + + P + V L C G+
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2417
Query: 296 PPPQVRWYCEGKELE-NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P V W + L+ SP I+ G SL I +D G Y C ASN G+D
Sbjct: 2418 PAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHYLCLASNSAGSDRQGR 2474
Query: 355 EI-YIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQ------ 407
++ +E + + S + P E S P V + + Q
Sbjct: 2475 DLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL 2534
Query: 408 PRVATIQQCQSPTNYLQ-------------GLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
P A + P + Q L + P + + + VV
Sbjct: 2535 PSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVL 2594
Query: 455 ECRVKGAPSPKVEWYREGT-LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
C G P+P V W + G L +R+ P E I + +G +
Sbjct: 2595 TCHSTGIPAPTVSWSKAGAQLGARGSGYRV---SPSGALE--------IGQALPIHAGRY 2643
Query: 514 TCTASNKYGTVSSIAQLHV 532
TC+A N G +A HV
Sbjct: 2644 TCSARNSAG----VAHKHV 2658
Score = 40.4 bits (93), Expect = 0.011
Identities = 62/311 (19%), Positives = 103/311 (33%), Gaps = 48/311 (15%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP + + T L C G P P V W+ +G++L+ + ++L
Sbjct: 2480 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 2539
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
+ +D+ ++ C SN G + +Y V + D + + P ++
Sbjct: 2540 LLTAPGPQDSAQFECVVSNEVGE---AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTC 2596
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA------------- 433
T IP AQ SP+ L+ PI A
Sbjct: 2597 HSTG---IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2653
Query: 434 -----------APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+PV + + A + V+ C G P P + W +EG + +
Sbjct: 2654 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ 2713
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR-------GN 535
+L L IA ED+G + C A N G+ +L V+ G
Sbjct: 2714 VLPGG-----------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL 2762
Query: 536 EDLSNNGSLHS 546
DLS H+
Sbjct: 2763 PDLSTTEGSHA 2773
Score = 34.3 bits (77), Expect = 0.81
Identities = 50/269 (18%), Positives = 98/269 (36%), Gaps = 37/269 (13%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V + C V G PP V W +G L S + G+ H+L I++ D G ++C
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ--RTLLHGSGHTLRISKVQLADAGIFTCV 2103
Query: 343 ASNIYGTDSTSAEIYIEG---VSSSDSEGDPNKEEMNRIQKPNEVSSPPTT--------S 391
A++ G + + ++ + + + D + ++ P E P
Sbjct: 2104 AASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGE 2163
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK-----PIIAAPVFTKMLQ--NL 444
++ ++ Q L + A S + + + ++ P Q L
Sbjct: 2164 PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTEL 2223
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
S + G + C +G P P + W+++G + + E T V+
Sbjct: 2224 SLTPGAPMELLCDAQGTPQPNITWHKDGQAL--------------TRLENNSRATRVLR- 2268
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
D+G +TC A + G + ++ V+
Sbjct: 2269 --VRDAGLYTCLAESPAGAIEKSFRVRVQ 2295
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 108 bits (269), Expect = 4e-23
Identities = 93/338 (27%), Positives = 135/338 (39%), Gaps = 54/338 (15%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P+ + L TEGS CK G P P + W KDG+ +S ++ G+
Sbjct: 2845 VPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE--- 2901
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L +++ D G YT A N GR HL + LP+
Sbjct: 2902 -LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV--------------------- 2939
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F PGD G L C G P P + W +N +PV S
Sbjct: 2940 ------------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS---- 2983
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL-EKLQNC 1181
+ G +L +++ D+GTY C A N+ G+ +V VK+APV+ E
Sbjct: 2984 -EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ-----AVSFVHVKEAPVLQGEAFSYL 3037
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
P G ++L+C V G P P +W KD + + R HQ G L I ++ DA
Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLR---HQLQNG--SLTIHRTERDDA 3092
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQI-PPPMSVR 1278
G Y A+NE G+ L + + Q+ P M+VR
Sbjct: 3093 GRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVR 3130
Score = 99.0 bits (245), Expect = 3e-20
Identities = 87/319 (27%), Positives = 132/319 (41%), Gaps = 56/319 (17%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP+ TC + G+P P V W KD + H + R G L + G YT
Sbjct: 1948 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG----RLQLSRLQPAQAGTYT 2003
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N Q V ++ + R+ S+G + R H +
Sbjct: 2004 CVAENTQAEARKD---FVVAVLVAPRIRSSGVA--------------------REHHVL- 2039
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD-ASHKMLVRETGVHSLLIDPLT 1137
EG+ RLDC+ G PPP++ WL +G P+ D H + G SL++ L
Sbjct: 2040 -------EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLR 2090
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP---VRLECR 1194
DAG Y C+A N G+++ ++V+ P I + G P V + C
Sbjct: 2091 ASDAGAYTCVAHNPAGEDARLHTVNVLV-----PPTIKQGADGSGTLVSRPGELVTMVCP 2145
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
V G PP W KD +P + +R +H +G+ L I + +DAG +T A + AG+
Sbjct: 2146 VRGSPPIHVSWLKDGLPLPLS-QRTLLH--GSGHT-LRISKVQLADAGIFTCVAASPAGV 2201
Query: 1255 VSCTARLDIYAQWHHQIPP 1273
L + Q+PP
Sbjct: 2202 ADRNFTLQV------QVPP 2214
Score = 95.9 bits (237), Expect = 2e-19
Identities = 85/315 (26%), Positives = 128/315 (40%), Gaps = 48/315 (15%)
Query: 943 IAPIFDKRLKH-FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+AP+F R H V EG P + +C+ G+P PK+ W KDG+ + E ++
Sbjct: 969 VAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLP--GEGAGLQHVSAVG 1026
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER 1061
L++ +G YT +N G S L V P AG
Sbjct: 1027 RLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP-----QIAGP----------- 1070
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
+EP P + + + L+C +G PPP +TW +GQPV A +
Sbjct: 1071 -REP-------------PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV--GAELGL 1114
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
++ G SL ++ G Y C+A N G+ ELSV+ L+ L N
Sbjct: 1115 QLQNQG-QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD--LDPLTNI 1171
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDT---TGYACLLIQPAKK 1238
P+ L C +G+PPP W + E +S +DT G L + ++
Sbjct: 1172 TAALHSPLTLLCEAMGIPPPAIRWFRGEEP-------VSPGEDTYLLAGGWMLKMTQTQE 1224
Query: 1239 SDAGWYTLSAKNEAG 1253
D+G Y+ A NEAG
Sbjct: 1225 QDSGLYSCLASNEAG 1239
Score = 94.0 bits (232), Expect = 9e-19
Identities = 85/300 (28%), Positives = 113/300 (37%), Gaps = 50/300 (16%)
Query: 954 FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDD 1013
F VT +PV TC GIP P V W K G Q+ R ++ G +L I
Sbjct: 2675 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG----ALEIGQALPIH 2730
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G YT A N G L VQ+ P+ L S ++
Sbjct: 2731 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA---------------------- 2768
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
VA E L L C+ SG+P P +TW G V S ++L L I
Sbjct: 2769 ---------VAEEEVL--LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG----QLRI 2813
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ DAG Y CIA N G L V + PVI L + EG L C
Sbjct: 2814 AHASPEDAGNYLCIAKNSAGSAMGKTRLVV-----QVPPVIENGLPDLSTTEGSHAFLPC 2868
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ G P P W KD + + + ++ LL++ + DAG YT +A+N G
Sbjct: 2869 KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE----LLVKNLEGQDAGTYTCTAENAVG 2924
Score = 93.2 bits (230), Expect = 1e-18
Identities = 86/298 (28%), Positives = 119/298 (39%), Gaps = 46/298 (15%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V E + VT C G+P P V WFK + +S + DG L IE D G
Sbjct: 706 VLENASVTLECLASGVPPPDVSWFKGHQPVS---SWMGVTVSVDGRV-LRIEQAQLSDAG 761
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+Y +A+N G L V ++P R L +
Sbjct: 762 SYRCVASNVAGSTELRYGLRV-NVPPRITLPPS--------------------------- 793
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
PG ++ + RL C +G P P L WL +G PV P + + V G L +
Sbjct: 794 --LPGPVLVNTP--VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG-RVLTLAS 848
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
D+G Y C+A + G++ + L +V P IL + N V V LEC+
Sbjct: 849 ARASDSGRYSCVAVSAVGEDRQDVVL-----QVHMPPSILGEELNVSVVANESVALECQS 903
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
MPPPV W KD + R + + D A L + A DAG YT A N+AG
Sbjct: 904 HAMPPPVLSWWKDGRPLE-PRPGVHLSADK---ALLQVDRADVWDAGHYTCEALNQAG 957
Score = 92.8 bits (229), Expect = 2e-18
Identities = 92/360 (25%), Positives = 143/360 (39%), Gaps = 66/360 (18%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
SP+T C+ +GIP P + WF+ + +S + + G L + T D G Y+
Sbjct: 1177 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA----GGWMLKMTQTQEQDSGLYSC 1232
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
+A+N G + + V P ++ D E +
Sbjct: 1233 LASNEAGEARRNFSVEVLVPP----------------SIENEDLEEV------------- 1263
Query: 1080 GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
+ +G+ L C V+G P P+LTW +G+P+ +H + GV L +
Sbjct: 1264 --IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHH--ISPDGV-LLQVLQANLS 1318
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG-----VPEGHPVRLECR 1194
AG Y CIA N G+ + +LSV+ AP IL ++ V +P+ L C
Sbjct: 1319 SAGHYSCIAANAVGEKTKHFQLSVLL-----APTILGGAEDSADEEVTVTVNNPISLICE 1373
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
+ P P W KD +R I + T G L I A+K DAG YT NE G
Sbjct: 1374 ALAFPSPNITWMKDGAPFEASR-NIQLLPGTHG---LQILNAQKEDAGQYTCVVTNELG- 1428
Query: 1255 VSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSV 1314
+ +H ++ P PS S+ L G + + + ST+ C S +V
Sbjct: 1429 -------EAVKNYHVEVLIP----PSISKDDPLGEVG--VKEVKTKVNSTLTLECESWAV 1475
Score = 90.5 bits (223), Expect = 1e-17
Identities = 84/334 (25%), Positives = 147/334 (44%), Gaps = 41/334 (12%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+ + +K + S +T C+ +P P + W+KDG+ ++ + +++ G+G L
Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSS---RLQVLGEGRL-L 1504
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I+ T D G Y +A N G ++++Q P+ ++ + SR +E
Sbjct: 1505 QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 1564
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
+ R ++V E L C + +PPP+LTW QP+ A ++ V
Sbjct: 1565 VTEYR-----------EIV--ENNPAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVL 1609
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL----EKLQN 1180
+ G L I + +AG Y C A+N+ G++ EL V+ PVIL E ++
Sbjct: 1610 QGG-RVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT-----PPVILGDTEELVEE 1663
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKS 1239
V V L+C +G P P W ++ +P + R+ + +D L + A+ +
Sbjct: 1664 VTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDG---QVLQVSTAEVA 1718
Query: 1240 DAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
DA Y A+N+AG L + Q+PP
Sbjct: 1719 DAASYMCVAENQAGSAEKLFTLRV------QVPP 1746
Score = 90.1 bits (222), Expect = 1e-17
Identities = 77/303 (25%), Positives = 120/303 (39%), Gaps = 45/303 (14%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+V +G C + G P PK+ WFKDG+ +++ + H DG L +
Sbjct: 1265 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVL-LQVLQANLSSA 1320
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G+Y+ +AAN G + L V P G V P+
Sbjct: 1321 GHYSCIAANAVGEKTKHFQLSVLLAP----TILGGAEDSADEEVTVTVNNPIS------- 1369
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
L C+ P P +TW+ +G P + ++L G H L I
Sbjct: 1370 -----------------LICEALAFPSPNITWMKDGAPFEASRNIQLL---PGTHGLQIL 1409
Query: 1135 PLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ DAG Y C+ TN+ G+ ++ +E+ + K P+ ++ + LE
Sbjct: 1410 NAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLE 1469
Query: 1193 CRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLL-IQPAKKSDAGWYTLSAKN 1250
C +PPP W KD + + P +R ++ G LL IQP + SD+G Y A N
Sbjct: 1470 CESWAVPPPTIRWYKDGQPVTPSSRLQV------LGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 1251 EAG 1253
AG
Sbjct: 1524 VAG 1526
Score = 88.6 bits (218), Expect = 4e-17
Identities = 98/399 (24%), Positives = 152/399 (38%), Gaps = 99/399 (24%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK-RNEHCKMRREGDGTCSLHIESTT 1010
+ V EG V C+ G P P V W KDG + + H + +G SL ++
Sbjct: 2034 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG---SLVLKGLR 2090
Query: 1011 SDDDGNYTIMAANPQGR-------------------------ISCSGHLMVQSLPIRS-- 1043
+ D G YT +A NP G +S G L+ P+R
Sbjct: 2091 ASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP 2150
Query: 1044 -----------------RLTSAGQSHRGR-SRVQERDK----------EPLQERFFRPHF 1075
R G H R S+VQ D + +R F
Sbjct: 2151 PIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV 2210
Query: 1076 LQAP--------GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P D+V G L L C+ G+P P ++W+ +G+P+L + E G
Sbjct: 2211 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS------LEQG 2264
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ--NCGVPE 1185
SL ++ + D+GTY C+A ++ G+ +L+V+ + P I + Q +
Sbjct: 2265 -PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM-----EPPHIEDSGQPTELSLTP 2318
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
G P+ L C G P P W KD + + R+ + T + + DAG YT
Sbjct: 2319 GAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRAT-------RVLRVRDAGLYT 2367
Query: 1246 LSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRY 1284
A++ AG + + R+ + A PP V P G R+
Sbjct: 2368 CLAESPAGAIEKSFRVRVQA-------PPNIVGPRGPRF 2399
Score = 87.4 bits (215), Expect = 8e-17
Identities = 79/300 (26%), Positives = 116/300 (38%), Gaps = 58/300 (19%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+T G+P+ C G P P + W KDG+ +++ + + R L + D G
Sbjct: 2316 LTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV------LRVR-----DAG 2364
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT +A +P G I S + VQ+ P + V R P F
Sbjct: 2365 LYTCLAESPAGAIEKSFRVRVQAPP---------------NIVGPRG----------PRF 2399
Query: 1076 LQ--APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
+ APG +V L+C V P P++TW +G + DA + R L +
Sbjct: 2400 VVGLAPGQLV--------LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG---RFLQL 2448
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
L+ D+G Y C A N G S + + E+ P I V L C
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRV-----EIHTVPTIRSGPPAVNVSVNQTALLPC 2503
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ G+P P+ W+KD + R + + L IQP DAG Y A N AG
Sbjct: 2504 QADGVPAPLVSWRKDRVPLDPRSPRFEILPE----GSLRIQPVLAQDAGHYLCLASNSAG 2559
Score = 85.9 bits (211), Expect = 2e-16
Identities = 70/229 (30%), Positives = 99/229 (43%), Gaps = 32/229 (13%)
Query: 1068 ERFFRPHFLQAPG-----------DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD 1116
E+F PH P +++ G L C SG+P P++ W + QPVLP
Sbjct: 202 EQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 261
Query: 1117 ASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI-- 1174
H + V+E G L I D G Y+C+A + GQ + +L V A P I
Sbjct: 262 GPH-LQVQEDG-QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA-----PPTIWG 314
Query: 1175 LEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQ 1234
+ V E H V+L C G+P P W KD +P + + + T G L +
Sbjct: 315 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY----TRGGRQLQLG 370
Query: 1235 PAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSR 1283
A+ SDAG YT A N G RLD+Y +PP ++ +G R
Sbjct: 371 RAQSSDAGVYTCKASNAVGAAEKATRLDVY------VPP--TIEGAGGR 411
Score = 85.5 bits (210), Expect = 3e-16
Identities = 84/328 (25%), Positives = 125/328 (38%), Gaps = 64/328 (19%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +PV TC G P P + W KDG +S G +L S + D G
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTL--ASARASDSG 855
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ +A + G R Q H S + E
Sbjct: 856 RYSCVAVSAVGE---------------DRQDVVLQVHMPPSILGE--------------- 885
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----- 1130
+ +VA+E L+C+ +PPP L+W +G+P+ P GVH
Sbjct: 886 -ELNVSVVANES--VALECQSHAMPPPVLSWWKDGRPLEP---------RPGVHLSADKA 933
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI-LEKLQNCGVPEGHP 1188
L +D DAG Y C A N+ G++ L+V APV L + V EGHP
Sbjct: 934 LLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWV-----APVFPLRESHTLTVREGHP 988
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
L C G+P P W+KD + +P E + + L + A+ + G YT
Sbjct: 989 TSLSCECRGVPFPKISWRKDGQPLP--GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 1046
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
N G S +L+++ +PP ++
Sbjct: 1047 SNVVGNSSQDLQLEVH------VPPQIA 1068
Score = 82.8 bits (203), Expect = 2e-15
Identities = 82/340 (24%), Positives = 137/340 (40%), Gaps = 57/340 (16%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G+ V C G+P P+V W KD + + H +++ +G L I + D+G Y
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ---VLRITGSHVGDEGRYQ 288
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A +P G+ + L V + P T G +
Sbjct: 289 CVAFSPAGQQARDFQLRVHAPP-----TIWGSNE-------------------------- 317
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
G++ E L +L C+ G+P P +TW +G +LP ++ + R G L +
Sbjct: 318 TGEVAVMEDHLVQLLCEARGVPTPNITWFKDG-ALLPTSTKVVYTR--GGRQLQLGRAQS 374
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKA---PVILEKLQNCGVPEGHPVRLECR 1194
DAG Y C A+N G + L V V ++ A P +++ + G PV LEC
Sbjct: 375 SDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV------AGRPVALECV 428
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G P P W +E +P S +T G L P + S +G Y+ A + AG
Sbjct: 429 ARGHPSPTLSW--HHEGLPVAESNES-RLETDGSVLRLESPGEAS-SGLYSCVASSPAGE 484
Query: 1255 VSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDI 1294
+++ Q+PP + V + ++ + L++
Sbjct: 485 AVLQYSVEV------QVPPQLLVAEGLGQVTTIVGQPLEL 518
Score = 82.8 bits (203), Expect = 2e-15
Identities = 74/312 (23%), Positives = 116/312 (37%), Gaps = 44/312 (14%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V E V C+ G+P P + WFKDG + + R G L + S D G
Sbjct: 323 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR----GGRQLQLGRAQSSDAG 378
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT A+N G + L V P + AG RP+
Sbjct: 379 VYTCKASNAVGAAEKATRLDVYVPP---TIEGAGG---------------------RPYV 414
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++A GR L+C G P P L+W G PV ++ ET L ++
Sbjct: 415 VKAVA------GRPVALECVARGHPSPTLSWHHEGLPVAESNESRL---ETDGSVLRLES 465
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
+ +G Y C+A++ G+ + V +V ++ E L G P+ L C+
Sbjct: 466 PGEASSGLYSCVASSPAGEAVLQYSVEV---QVPPQLLVAEGLGQVTTIVGQPLELPCQA 522
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G P P W ++ E ++ Q + L I + +G + A NEAG
Sbjct: 523 SGSPVPTIQWLQNGR----PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 578
Query: 1256 SCTARLDIYAQW 1267
+ ++ +W
Sbjct: 579 GAEVEVSVHGEW 590
Score = 75.1 bits (183), Expect = 4e-13
Identities = 81/342 (23%), Positives = 130/342 (38%), Gaps = 62/342 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+ E +P C IP P + W+++ + +S +E ++ G L I +++ G
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ----GGRVLQIPLVRAENAG 1626
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ A+N G L+V + P+ D E L E
Sbjct: 1627 RYSCKASNEVGEDWLHYELLVLTPPVILG-----------------DTEELVE------- 1662
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++ + L C G P P ++WL NG P P S ++ V E G L +
Sbjct: 1663 -----EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDG-QVLQVST 1714
Query: 1136 LTQRDAGTYKCIATNKTG--QNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPV 1189
DA +Y C+A N+ G + F+L + V + ++++ IL V
Sbjct: 1715 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS----------SV 1764
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
L C V P P W KD++ + E + G L + A+ SD+G YT A
Sbjct: 1765 SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL----PGTHTLQLGRARLSDSGMYTCEAL 1820
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKG 1291
N AG +L + +PP P G + L G
Sbjct: 1821 NAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVG 1856
Score = 74.3 bits (181), Expect = 7e-13
Identities = 71/292 (24%), Positives = 115/292 (39%), Gaps = 53/292 (18%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C+ G+P P V W KD + R+ ++ EG SL I+ + D G+Y +A+N
Sbjct: 2503 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG----SLRIQPVLAQDAGHYLCLASN-- 2556
Query: 1026 GRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAH 1085
SAG +GR R EP P +P ++
Sbjct: 2557 ---------------------SAGSDRQGRDL---RVLEP-------PAIAPSPSNLTLT 2585
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPV---LPDASHKMLVRETGVHSLLIDPLTQRDAG 1142
L C+ SG P P + W +GQ + L ++++L ++LL+ +D+
Sbjct: 2586 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS----NALLLTAPGPQDSA 2641
Query: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
++C+ +N+ G+ +++ V P I + + V PV L C G+P P
Sbjct: 2642 QFECVVSNEVGEAHRLYQVT-----VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT 2696
Query: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
W K + + L I A AG YT SA+N AG+
Sbjct: 2697 VSWSKAGAQLGARGSGYRVSPS----GALEIGQALPIHAGRYTCSARNSAGV 2744
Score = 73.9 bits (180), Expect = 9e-13
Identities = 76/292 (26%), Positives = 109/292 (37%), Gaps = 46/292 (15%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
S V+ C + P P+V W+KD + +S E + GT +L + D G YT
Sbjct: 1762 SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL----PGTHTLQLGRARLSDSGMYTC 1817
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
A N GR L V P + Q+ RG P
Sbjct: 1818 EALNAAGRDQKLVQLSVLVPP------AFRQAPRG------------------------P 1847
Query: 1080 GDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
D V G L C+ LP P +TW +GQP++ + L G L I
Sbjct: 1848 QDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQAL---RGGQRLEIQEAQV 1904
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
D G Y C +N G+ + L+V + P K + G P+ L C V G+
Sbjct: 1905 SDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCDVSGV 1960
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
P P W KD + E ++H + L + + + AG YT A+N
Sbjct: 1961 PAPTVTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 2008
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/289 (22%), Positives = 114/289 (39%), Gaps = 49/289 (16%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C + P PK+ W +DG + + + H + G L +++ ++ D G+Y+ A N
Sbjct: 2412 CSVEAEPAPKITWHRDGI-VLQEDAHTQFPERGR---FLQLQALSTADSGDYSCTARNAA 2467
Query: 1026 GRISCSGHLMVQSLP-IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA 1084
G S + + + ++P IRS P +
Sbjct: 2468 GSTSVAFRVEIHTVPTIRS----------------------------------GPPAVNV 2493
Query: 1085 HEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTY 1144
+ L C+ G+P P ++W + P+ P + ++ E SL I P+ +DAG Y
Sbjct: 2494 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHY 2550
Query: 1145 KCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFY 1204
C+A+N G + +L V+ + P I N + P L C G P P+
Sbjct: 2551 LCLASNSAGSDRQGRDLRVL-----EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVV 2605
Query: 1205 WKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
W KD + + R + ++ A LL P + D+ + NE G
Sbjct: 2606 WWKDGQKLD-FRLQQGAYRLLPSNALLLTAPGPQ-DSAQFECVVSNEVG 2652
Score = 73.2 bits (178), Expect = 2e-12
Identities = 80/328 (24%), Positives = 125/328 (38%), Gaps = 67/328 (20%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V GS V C+ G+P+P V W KDG+ + ++ +G SL +E+ + D G
Sbjct: 2227 VVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS-----LEQGP---SLQLEAVGAGDSG 2278
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ +A + G L V P + +GQ
Sbjct: 2279 TYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQ------------------------- 2310
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
P ++ G L C G P P +TW +GQ + ++ R V
Sbjct: 2311 ---PTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV------- 2360
Query: 1136 LTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLE 1192
RDAG Y C+A + G + SF + + V + P + G+ G V LE
Sbjct: 2361 ---RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFV-----VGLAPGQLV-LE 2411
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C V P P W +D + + + Q L +Q +D+G Y+ +A+N A
Sbjct: 2412 CSVEAEPAPKITWHRDGIVL----QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 2467
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
G S R++I H +P S P+
Sbjct: 2468 GSTSVAFRVEI-----HTVPTIRSGPPA 2490
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/195 (28%), Positives = 78/195 (40%), Gaps = 42/195 (21%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G + C + G PVP ++W KDG + R H + + + SL I T DD G Y
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPL--RGSHLRHQLQNG---SLTIHRTERDDAGRYQ 3096
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N G L++QS P+ F
Sbjct: 3097 CLAENEMGVAKKVVILVLQSAPV---------------------------------FQVE 3123
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
P DM G L C+ +G P P + WL GQP+ AS ++ G SL ++ +
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL--RASRRLRTLPDG--SLWLENVET 3179
Query: 1139 RDAGTYKCIATNKTG 1153
DAGTY C+A N G
Sbjct: 3180 GDAGTYDCVAHNLLG 3194
Score = 70.9 bits (172), Expect = 8e-12
Identities = 67/320 (20%), Positives = 125/320 (39%), Gaps = 59/320 (18%)
Query: 256 PSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI 315
P S+ ++PLG+ ++ + + + L+C +PPP +RWY +G+ + S +
Sbjct: 1441 PPSISKDDPLGEVG-----VKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 1495
Query: 316 HIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE---------------G 360
++ G L L I D+GRY C A+N+ G D + I+
Sbjct: 1496 QVLGEGRL--LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFE 1553
Query: 361 VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVP---QAQHLVAQPRVATIQ--- 414
+ S + E E I + N T+A+ PP + + Q L A V+ +Q
Sbjct: 1554 ILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGR 1613
Query: 415 ---------------QCQSPTN------YLQGLDGKPIIAAPVFTKMLQNLSASEGQLVV 453
C++ + + L P + ++++ ++ + V
Sbjct: 1614 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVS 1673
Query: 454 FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
+C G P P + W + G SP ++L E ++ + AEV D+ +
Sbjct: 1674 LQCPALGNPVPTISWLQNGLPFSPSPRLQVL--------EDGQVLQVSTAEV--ADAASY 1723
Query: 514 TCTASNKYGTVSSIAQLHVR 533
C A N+ G+ + L V+
Sbjct: 1724 MCVAENQAGSAEKLFTLRVQ 1743
Score = 69.7 bits (169), Expect = 2e-11
Identities = 67/278 (24%), Positives = 111/278 (39%), Gaps = 35/278 (12%)
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
RE+ E L C IPPP + WY E + L ++ ++Q G + + + A E+ G
Sbjct: 1569 REIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRA--ENAG 1626
Query: 338 RYSCFASNIYGTDSTSAEIYI--EGVSSSDSEGDPNKEEMN-----RIQKPNEVSSPPTT 390
RYSC ASN G D E+ + V D+E + +N +Q P + PT
Sbjct: 1627 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTI 1686
Query: 391 SAV---IPPAVPQAQHLVAQPRVATIQQCQ--SPTNYLQGLDGKPIIAAPVFTKM----- 440
S + +P + ++ +V + + +Y+ + + A +FT
Sbjct: 1687 SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPP 1746
Query: 441 ------LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
L+ ++A V C V P+P+V WY++ + + +L
Sbjct: 1747 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH------ 1800
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
TL + DSG +TC A N G + QL V
Sbjct: 1801 ----TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 1834
Score = 68.9 bits (167), Expect = 3e-11
Identities = 58/201 (28%), Positives = 80/201 (39%), Gaps = 15/201 (7%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P+ P + E L+C SG+PPP+++W QPV +S + L
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPV---SSWMGVTVSVDGRVLR 751
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I+ DAG+Y+C+A+N G L V P L V PVRL
Sbjct: 752 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG----PVLVNTPVRLT 807
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C G P P W KD P + Q G L + A+ SD+G Y+ A +
Sbjct: 808 CNATGAPSPTLMWLKDGN--PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 865
Query: 1253 GIVSCTARLDIYAQWHHQIPP 1273
G R D+ Q H +PP
Sbjct: 866 G----EDRQDVVLQVH--MPP 880
Score = 68.6 bits (166), Expect = 4e-11
Identities = 83/325 (25%), Positives = 121/325 (37%), Gaps = 47/325 (14%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G P+ C+ G PVP + W ++G+ E ++ GT +LHI+ D G +
Sbjct: 513 GQPLELPCQASGSPVPTIQWLQNGRPAE---ELAGVQVASQGT-TLHIDHVELDHSGLFA 568
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRL-TSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
A N G + V L GQ H G
Sbjct: 569 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSS---------------FP 613
Query: 1078 APGDMVAHEGRLCRLDCK-VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPL 1136
A D H G V G P W G+P ++ + L I+ +
Sbjct: 614 AACDPPVHRGWGAHPKPPLVEGWCSPGSLW---GEPTGIPVAYSL------PPPLQIEKV 664
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
RD G Y C ATN G++ + L V V ++ PV N V E V LEC
Sbjct: 665 DLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV------NKAVLENASVTLECLA 718
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G+PPP W K ++ + + +++ D L I+ A+ SDAG Y A N AG
Sbjct: 719 SGVPPPDVSWFKGHQPV-SSWMGVTVSVDG---RVLRIEQAQLSDAGSYRCVASNVAGST 774
Query: 1256 SCTARLDIYAQWHHQIPPPMSVRPS 1280
L + +PP +++ PS
Sbjct: 775 ELRYGLRV------NVPPRITLPPS 793
Score = 67.4 bits (163), Expect = 9e-11
Identities = 87/376 (23%), Positives = 134/376 (35%), Gaps = 63/376 (16%)
Query: 948 DKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIE 1007
++ ++ V S V+ C +G PVP + W ++G S + ++ +G L +
Sbjct: 1658 EELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP-SPRLQVLEDGQ---VLQVS 1713
Query: 1008 STTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQ 1067
+ D +Y +A N G L VQ P R+ D E
Sbjct: 1714 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPP----------------RIAGLDLE--- 1754
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
+ A L C V P PE+TW + Q + +L G
Sbjct: 1755 -------------QVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL---PG 1798
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAP-----VILEKLQNC 1181
H+L + D+G Y C A N G++ ++LSV V ++AP +L ++
Sbjct: 1799 THTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV--- 1855
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
G L C +P P W KD + + + Q G L IQ A+ SD
Sbjct: 1856 ----GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT----QALRGGQRLEIQEAQVSDK 1907
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSM 1301
G Y+ N AG T L + Q+PP P + L + S +
Sbjct: 1908 GLYSCKVSNVAGEAVRTFTLTV------QVPPTFE-NPKTETVSQVAGSPLVLTCDVSGV 1960
Query: 1302 ESTMVYSCSSRSVVES 1317
+ V R VES
Sbjct: 1961 PAPTVTWLKDRMPVES 1976
Score = 67.4 bits (163), Expect = 9e-11
Identities = 65/268 (24%), Positives = 103/268 (38%), Gaps = 37/268 (13%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
V L C GIP P + W EG + ++ G L IA A ED G Y C A N
Sbjct: 2774 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLR---IAHASPEDAGNYLCIAKN 2830
Query: 346 IYGTDSTSAEIYIE-------GVSS-SDSEGD----PNKEEMNRIQKPN--------EVS 385
G+ + ++ G+ S +EG P K + +PN VS
Sbjct: 2831 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGS--PEPNITWDKDGQPVS 2888
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLS 445
+ P ++L Q ++ + I+ PVFT + + S
Sbjct: 2889 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRS 2948
Query: 446 ASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEV 505
G + C +G+P+P++ W + D P ++E + TL A V
Sbjct: 2949 LRLGDRLWLRCAARGSPTPRIGW-----TVNDRP-------VTEGVSEQDGGSTLQRAAV 2996
Query: 506 FAEDSGCFTCTASNKYGTVSSIAQLHVR 533
EDSG + C A N+ G +++ +HV+
Sbjct: 2997 SREDSGTYVCWAENRVGRTQAVSFVHVK 3024
Score = 64.7 bits (156), Expect = 6e-10
Identities = 59/222 (26%), Positives = 90/222 (40%), Gaps = 41/222 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+ G PV C G P P + W +G +++ NE R E DG+ L +ES
Sbjct: 416 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES---RLETDGSV-LRLESPGEASS 471
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G Y+ +A++P G + VQ P L + G
Sbjct: 472 GLYSCVASSPAGEAVLQYSVEVQVPP--QLLVAEGL------------------------ 505
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
G + G+ L C+ SG P P + WL NG+P A ++ + T +H ID
Sbjct: 506 -----GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLH---ID 557
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILE 1176
+ +G + C ATN+ G +E+SV + AP +LE
Sbjct: 558 HVELDHSGLFACQATNEAGTAGAEVEVSV---HGEWAPGVLE 596
Score = 63.2 bits (152), Expect = 2e-09
Identities = 81/331 (24%), Positives = 117/331 (35%), Gaps = 59/331 (17%)
Query: 239 EQAASEAAGGDTTPGSS---PSSLYYEEPLGQPPRFT-QKLRSREVPEGTRVQLDCIVVG 294
EQA AG S+ + L Y + PPR T V T V+L C G
Sbjct: 753 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATG 812
Query: 295 IPPPQVRWYCEGKELE--NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P + W +G + +P + + G + LT+A A D+GRYSC A + G D
Sbjct: 813 APSPTLMWLKDGNPVSPAGTPGLQVFPGGRV--LTLASARASDSGRYSCVAVSAVGEDRQ 870
Query: 353 SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAV------------PQ 400
+ + S EE+N NE + S +PP V
Sbjct: 871 DVVLQVHMPPSILG------EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP 924
Query: 401 AQHLVAQPRVATIQQ----------CQSPTNYLQGLDGK----PIIAAPVF-TKMLQNLS 445
HL A + + + C++ G K + APVF + L+
Sbjct: 925 GVHLSADKALLQVDRADVWDAGHYTCEALNQ--AGRSEKHYNLNVWVAPVFPLRESHTLT 982
Query: 446 ASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT----LV 501
EG C +G P PK+ W ++G Q P A + + L
Sbjct: 983 VREGHPTSLSCECRGVPFPKISWRKDG------------QPLPGEGAGLQHVSAVGRLLY 1030
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ + G +TC SN G S QL V
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 1061
Score = 62.4 bits (150), Expect = 3e-09
Identities = 72/341 (21%), Positives = 129/341 (37%), Gaps = 50/341 (14%)
Query: 208 RSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQ 267
+ +P+P+ T + H L + + +A AA + + P+ +
Sbjct: 2158 KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 2217
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK-----ELENSPDIHIVQAGN 322
P F + V G+ V+L C G+P P V W +G+ LE P + + G
Sbjct: 2218 PVEFQNDV---VVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVG- 2273
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK------EEMN 376
D+G YSC A + G ++ + + G P + M
Sbjct: 2274 ----------AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPME 2323
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQC-------QSPTNYLQG---- 425
+ P T A+ + ++ RV ++ +SP ++
Sbjct: 2324 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 2383
Query: 426 -LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P I P + + L+ GQLV+ EC V+ P+PK+ W+R+G ++++ +
Sbjct: 2384 RVQAPPNIVGPRGPRFVVGLAP--GQLVL-ECSVEAEPAPKITWHRDGIVLQEDAHTQF- 2439
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
PE L + + DSG ++CTA N G+ S
Sbjct: 2440 ---------PERGRFLQLQALSTADSGDYSCTARNAAGSTS 2471
Score = 62.0 bits (149), Expect = 4e-09
Identities = 70/286 (24%), Positives = 109/286 (38%), Gaps = 51/286 (17%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V E VQL C G+P P + W+ +G L S + + G L + A D G Y
Sbjct: 323 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG--RQLQLGRAQSSDAGVY 380
Query: 340 SCFASNIYGT--DSTSAEIY----IEGVSS-----SDSEGDPNKEEMNRIQKPNEVSSPP 388
+C ASN G +T ++Y IEG G P E P+ P
Sbjct: 381 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS-----P 435
Query: 389 TTS---AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--------DGKPIIAAPVF 437
T S +P A L ++ + +SP GL G+ ++ V
Sbjct: 436 TLSWHHEGLPVAESNESRLETD---GSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 492
Query: 438 TKMLQNLSASE---------GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
++ L +E GQ + C+ G+P P ++W + G E+ ++ +
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG- 551
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
TL I V + SG F C A+N+ GT + ++ V G
Sbjct: 552 ---------TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/298 (22%), Positives = 107/298 (35%), Gaps = 53/298 (17%)
Query: 276 RSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEED 335
R V EG V+LDC G PPP V W +G L H+ + SL + D
Sbjct: 2034 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2093
Query: 336 TGRYSCFASNIYGTDST--SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV--------S 385
G Y+C A N G D+ + + + ++G + +P E+
Sbjct: 2094 AGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG-----TLVSRPGELVTMVCPVRG 2148
Query: 386 SPPTTSAVIPPAVP----QAQHLVAQPRVATIQQCQ------------SPT-----NYLQ 424
SPP + + +P Q L I + Q SP N+
Sbjct: 2149 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 2208
Query: 425 GLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P++ F ++ G LV C +G P P V W ++G
Sbjct: 2209 QVQVPPVLEPVEFQ---NDVVVVRGSLVELPCEARGVPLPLVSWMKDG------------ 2253
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+P E+ +L + V A DSG ++C A ++ G QL V + ++G
Sbjct: 2254 --EPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 2309
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 37/286 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT R + G R+ L C G P P++ W + + + + +L
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG----VSEQDGGSTLQR 2993
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEM--NRIQKPNEVSS 386
A ED+G Y C+A N G + ++++ E E IQ V
Sbjct: 2994 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG 3053
Query: 387 PPTTSAV-IPPAVP-QAQHLVAQPRVATIQ------------QCQSPTNYLQGLDGKPII 432
P I +P + HL Q + ++ QC + G+ K +I
Sbjct: 3054 DPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENE--MGVAKKVVI 3111
Query: 433 ----AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+APVF Q+++ G V C+ G P+P +EW + G + S R L
Sbjct: 3112 LVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG- 3170
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+L + V D+G + C A N G+ ++ A L VRG
Sbjct: 3171 ----------SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206
Score = 60.1 bits (144), Expect = 1e-08
Identities = 68/295 (23%), Positives = 115/295 (38%), Gaps = 45/295 (15%)
Query: 268 PPRFTQKLRSRE----VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PP F Q R + V G + L C +P P V WY +G+ L + ++ G
Sbjct: 1837 PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGG-- 1894
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
L I EA D G YSC SN+ G + + V + +P E ++++
Sbjct: 1895 QRLEIQEAQVSDKGLYSCKVSNVAG---EAVRTFTLTVQVPPTFENPKTETVSQVAGSPL 1951
Query: 384 VSSPPTTSAVIP---------PAVPQAQHLV----AQPRVATIQQCQSPT-----NYLQG 425
V + + P P A H V + +++ +Q Q+ T Q
Sbjct: 1952 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 2011
Query: 426 LDGKPIIAAPVFTKMLQNLSAS------EGQLVVFECRVKGAPSPKVEWYREGTLI--ED 477
K + A + +++ + EGQ V +C G P P V W ++G+ + +
Sbjct: 2012 EARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDM 2071
Query: 478 SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
P R + +LV+ + A D+G +TC A N G + + ++V
Sbjct: 2072 GPHLRFYL----------DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 2116
Score = 58.2 bits (139), Expect = 5e-08
Identities = 63/277 (22%), Positives = 107/277 (38%), Gaps = 62/277 (22%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKE-LENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
G V+L C G+P PQV W + + L P + + + G + L I + D GRY C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV--LRITGSHVGDEGRYQC 289
Query: 342 FASNIYGTDSTSAEIYIEG---VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS------- 391
A + G + ++ + + S+ G+ E + +Q E PT +
Sbjct: 290 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349
Query: 392 AVIPPAVP--------QAQHLVAQPRVATIQQCQS------------------PTNYLQG 425
A++P + Q Q AQ A + C++ PT ++G
Sbjct: 350 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT--IEG 407
Query: 426 LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQ 485
G+P + + A G+ V EC +G PSP + W+ EG + +S + R+
Sbjct: 408 AGGRPYV-----------VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL-- 454
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ L + SG ++C AS+ G
Sbjct: 455 --------ETDGSVLRLESPGEASSGLYSCVASSPAG 483
Score = 57.0 bits (136), Expect = 1e-07
Identities = 57/286 (19%), Positives = 102/286 (35%), Gaps = 33/286 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP ++ V E V L+C+ G+PPP V W+ + + + + + G + L
Sbjct: 694 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV--LR 751
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE---------GVSSSDSEGDPNKEEMNRI 378
I +A D G Y C ASN+ G+ + + + P + N
Sbjct: 752 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 811
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTN--------YLQGLDGKP 430
P+ + PA + RV T+ ++ + G D +
Sbjct: 812 GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD 871
Query: 431 II----AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
++ P N+S + V EC+ P P + W+++G +E P +
Sbjct: 872 VVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD 931
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
K + ++ D+G +TC A N+ G L+V
Sbjct: 932 KALLQVDRADVW----------DAGHYTCEALNQAGRSEKHYNLNV 967
Score = 56.6 bits (135), Expect = 2e-07
Identities = 59/264 (22%), Positives = 98/264 (37%), Gaps = 30/264 (11%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C V P P++ W+ +G L+ + G L + D+G YSC A N
Sbjct: 2410 LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF--LQLQALSTADSGDYSCTARNAA 2467
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK--------PNEVSSPPTTSAVIPPAVP 399
G+ S + + I V + S +N+ P + S + P P
Sbjct: 2468 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 2527
Query: 400 QAQHLVAQPRVATIQQCQSPTNYL-----------QGLDGKPIIAAPVFTKMLQNLSASE 448
+ + L Q +YL QG D + ++ P NL+ +
Sbjct: 2528 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR-VLEPPAIAPSPSNLTLTA 2586
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C G+P P V W+++G + DFR+ Q R + L++ +
Sbjct: 2587 HTPALLPCEASGSPKPLVVWWKDGQKL----DFRLQQGAYRLLPSN----ALLLTAPGPQ 2638
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
DS F C SN+ G + Q+ V
Sbjct: 2639 DSAQFECVVSNEVGEAHRLYQVTV 2662
Score = 55.8 bits (133), Expect = 3e-07
Identities = 59/274 (21%), Positives = 103/274 (37%), Gaps = 42/274 (15%)
Query: 279 EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGR 338
+V +G L C V G P P++ W+ +G+ L HI G L L + +A G
Sbjct: 1265 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL--LQVLQANLSSAGH 1322
Query: 339 YSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVS---------SPPT 389
YSC A+N G + ++ + + + + +E + N +S SP
Sbjct: 1323 YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI 1382
Query: 390 T------------SAVIPPAVPQAQHLVAQPR-------VATIQQCQSPTNYLQGLDGKP 430
T + + P Q L AQ V T + ++ NY + P
Sbjct: 1383 TWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1442
Query: 431 IIAA--PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
I+ P+ ++ + + EC P P + WY++G + S ++L +
Sbjct: 1443 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1502
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+P ++ DSG + C A+N G
Sbjct: 1503 LLQIQPTQV----------SDSGRYLCVATNVAG 1526
Score = 54.3 bits (129), Expect = 8e-07
Identities = 62/284 (21%), Positives = 102/284 (35%), Gaps = 61/284 (21%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+ L C + P P + W +G E S +I ++ H L I A +ED G+Y+C +N
Sbjct: 1368 ISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG--THGLQILNAQKEDAGQYTCVVTN 1425
Query: 346 IYGTDSTSAEIYI---EGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIP------- 395
G + + + +S D G+ +E+ K N + S +P
Sbjct: 1426 ELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK--TKVNSTLTLECESWAVPPPTIRWY 1483
Query: 396 ----PAVPQAQ-HLVAQPRVATIQ--QCQSPTNYL---------QGLDGKPIIAAPVFTK 439
P P ++ ++ + R+ IQ Q YL D +I P +
Sbjct: 1484 KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQ 1543
Query: 440 MLQNLSAS---------------------EGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
+ + SA+ E C P P + WYRE +
Sbjct: 1544 KVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAG 1603
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ +LQ L I V AE++G ++C ASN+ G
Sbjct: 1604 DEVSVLQGGR----------VLQIPLVRAENAGRYSCKASNEVG 1637
Score = 53.5 bits (127), Expect = 1e-06
Identities = 57/268 (21%), Positives = 100/268 (37%), Gaps = 35/268 (13%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C G PPP V W +G+ + + + G SL + A TGRYSC A N+
Sbjct: 1087 LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ--SLHVERAQAAHTGRYSCVAENLA 1144
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP-----NEVSSPPTT----SAVIPPAV 398
G E+ + + DP + P + PP P +
Sbjct: 1145 GRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1204
Query: 399 PQAQHLVAQPRVATIQQCQSPTNYL-------------QGLDGKPIIAAPVFTKMLQN-L 444
+ +L+A + + Q Q + L + + ++ + + L+ +
Sbjct: 1205 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVI 1264
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
+GQ C V G P PK+ W+++G R L + P+ + L + +
Sbjct: 1265 KVLDGQTAHLMCNVTGHPQPKLTWFKDG---------RPLARGDAHHISPDGV-LLQVLQ 1314
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+G ++C A+N G + QL V
Sbjct: 1315 ANLSSAGHYSCIAANAVGEKTKHFQLSV 1342
Score = 50.8 bits (120), Expect = 8e-06
Identities = 40/128 (31%), Positives = 55/128 (42%), Gaps = 23/128 (17%)
Query: 1094 CKVSGLPPPELTWL-------LNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKC 1146
C G P P++TW L+GQP + V E G SL + ++ D+G Y+C
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQP-------GVAVLEEG--SLFLASVSPADSGDYEC 74
Query: 1147 IATNKTGQNSFSLELSVVAKEVKKAPVILE--KLQNCGVPEGHPVRLECRVIGMPPPVFY 1204
ATN+ G S +L V P I E + N G + LEC G P P
Sbjct: 75 QATNEVGSTSRRAKLVVYV-----PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 129
Query: 1205 WKKDNETI 1212
W KD + +
Sbjct: 130 WLKDAQLV 137
Score = 50.4 bits (119), Expect = 1e-05
Identities = 60/271 (22%), Positives = 106/271 (39%), Gaps = 45/271 (16%)
Query: 290 CIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
C +GIPPP +RW+ + + D +++ G + L + + E+D+G YSC ASN G
Sbjct: 1183 CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM--LKMTQTQEQDSGLYSCLASNEAGE 1240
Query: 350 DSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN------EVSSPPTTSAV-----IPPAV 398
+ + + S ++E + EE+ ++ V+ P P A
Sbjct: 1241 ARRNFSVEVLVPPSIENE---DLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 1297
Query: 399 PQAQHL--------VAQPRVATIQQCQSPTNYLQGLDGK----PIIAAPVFTKMLQNLSA 446
A H+ V Q +++ G K ++ AP ++ +
Sbjct: 1298 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1357
Query: 447 SEGQLVV-----FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
E + V C PSP + W ++G E S + ++L P + L
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLL---PGTHG-------LQ 1407
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
I ED+G +TC +N+ G ++ HV
Sbjct: 1408 ILNAQKEDAGQYTCVVTNELG--EAVKNYHV 1436
Score = 50.4 bits (119), Expect = 1e-05
Identities = 72/319 (22%), Positives = 107/319 (33%), Gaps = 56/319 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+T +P C+ G P P V W+KDG+++ R + R +L + + D
Sbjct: 2584 LTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN--ALLLTAPGPQDSA 2641
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+ + +N G++HR Q P P
Sbjct: 2642 QFECVVSN-----------------------EVGEAHR---LYQVTVHVP-------PTI 2668
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
D L C +G+P P ++W G + S R + +L I
Sbjct: 2669 ADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG---YRVSPSGALEIGQ 2725
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLECR 1194
AG Y C A N G + L+V A V K P ++ + V L C
Sbjct: 2726 ALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE------EEVLLPCE 2779
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G+P P W+K+ + + L I A DAG Y AKN AG
Sbjct: 2780 ASGIPRPTITWQKEGLNVAT-----GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Query: 1255 VSCTARLDIYAQWHHQIPP 1273
RL + Q+PP
Sbjct: 2835 AMGKTRLVV------QVPP 2847
Score = 48.5 bits (114), Expect = 4e-05
Identities = 60/274 (21%), Positives = 101/274 (36%), Gaps = 48/274 (17%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V EG L C G+P P++ W +G+ L E + H+ G L L A+ +E G
Sbjct: 983 VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--G 1040
Query: 338 RYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-----------EMNRIQKPNEVSS 386
Y+C SN+ G S ++ + +P + E N KP
Sbjct: 1041 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP----- 1095
Query: 387 PPTTS---AVIPPAVPQAQHLVAQPRVATIQQCQSP-----TNYLQGLDGK-------PI 431
PPT + P L Q + +++ Q+ + + L G+ +
Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV 1155
Query: 432 IAAPVF---TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+ P L N++A+ + C G P P + W+R + D +L
Sbjct: 1156 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG- 1214
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
L + + +DSG ++C ASN+ G
Sbjct: 1215 ---------WMLKMTQTQEQDSGLYSCLASNEAG 1239
Score = 45.1 bits (105), Expect = 5e-04
Identities = 75/351 (21%), Positives = 116/351 (33%), Gaps = 75/351 (21%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSS---LYYEEPLGQPPRF--TQKLRS 277
E N + + + E ++G + SSP+ L Y + PP+ + L
Sbjct: 448 ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ 507
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
G ++L C G P P ++W G+ E + + G +L I + +G
Sbjct: 508 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSG 565
Query: 338 RYSCFASNIYGTDSTSAEIYIEGV--------------------SSSDSEGDPNKEE--- 374
++C A+N GT E+ + G SS + DP
Sbjct: 566 LFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 625
Query: 375 -------MNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNY----- 422
+ P + PT V P Q R I C + TN
Sbjct: 626 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTC-AATNLAGESK 684
Query: 423 ----LQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIED- 477
L+ L I PV +L+N S V EC G P P V W++ +
Sbjct: 685 REVALKVLVPPNIEPGPVNKAVLENAS------VTLECLASGVPPPDVSWFKGHQPVSSW 738
Query: 478 -----SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
S D R+L+ I + D+G + C ASN G+
Sbjct: 739 MGVTVSVDGRVLR----------------IEQAQLSDAGSYRCVASNVAGS 773
Score = 44.7 bits (104), Expect = 6e-04
Identities = 55/290 (18%), Positives = 101/290 (34%), Gaps = 50/290 (17%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L EG+ L C G P P + W +G+ + + +Q L
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG--ELL 2903
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS-SSDSEGDPNKEEMNRIQKPNEVSS 386
+ +D G Y+C A N G + I + + GD + +R+
Sbjct: 2904 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARG 2963
Query: 387 PPTTSAVIPPAV-------PQAQHLVAQPRVATIQQC----QSPTNYLQGLDGK------ 429
PT P + P + + Q +T+Q+ + Y+ + +
Sbjct: 2964 SPT------PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 3017
Query: 430 ---------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
P++ F+ +++ + S + +C V+G P P + W ++G + S
Sbjct: 3018 VSFVHVKEAPVLQGEAFSYLVEPVGGS----IQLDCVVRGDPVPDIHWIKDGLPLRGSHL 3073
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
LQ +L I +D+G + C A N+ G + L
Sbjct: 3074 RHQLQNG-----------SLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 3112
Score = 44.3 bits (103), Expect = 8e-04
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP+F + V G V C+ G P P + W + G+ + ++R DG S
Sbjct: 3117 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASR---RLRTLPDG--S 3171
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L +E+ + D G Y +A N G + L+V+ P
Sbjct: 3172 LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 10/89 (11%)
Query: 444 LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIA 503
++ E LV C +G P+P + W+++G L+ S + + R L +
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKV-VYTRGGRQ---------LQLG 370
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ D+G +TC ASN G +L V
Sbjct: 371 RAQSSDAGVYTCKASNAVGAAEKATRLDV 399
Score = 42.0 bits (97), Expect = 0.004
Identities = 27/96 (28%), Positives = 39/96 (40%), Gaps = 3/96 (3%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L P F + + V G V L C G P P + W G+ L S + + G
Sbjct: 3114 LQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG--- 3170
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
SL + D G Y C A N+ G+ + A + + G
Sbjct: 3171 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 3206
Score = 40.8 bits (94), Expect = 0.009
Identities = 70/319 (21%), Positives = 106/319 (33%), Gaps = 44/319 (13%)
Query: 240 QAASEAAGGDTT----PGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
QA S A GD + + +S+ + + P + V L C G+
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2508
Query: 296 PPPQVRWYCEGKELE-NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P V W + L+ SP I+ G SL I +D G Y C ASN G+D
Sbjct: 2509 PAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHYLCLASNSAGSDRQGR 2565
Query: 355 EI-YIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQ------ 407
++ +E + + S + P E S P V + + Q
Sbjct: 2566 DLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL 2625
Query: 408 PRVATIQQCQSPTNYLQ-------------GLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
P A + P + Q L + P + + + VV
Sbjct: 2626 PSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVL 2685
Query: 455 ECRVKGAPSPKVEWYREGT-LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
C G P+P V W + G L +R+ P E I + +G +
Sbjct: 2686 TCHSTGIPAPTVSWSKAGAQLGARGSGYRV---SPSGALE--------IGQALPIHAGRY 2734
Query: 514 TCTASNKYGTVSSIAQLHV 532
TC+A N G +A HV
Sbjct: 2735 TCSARNSAG----VAHKHV 2749
Score = 40.4 bits (93), Expect = 0.011
Identities = 62/311 (19%), Positives = 103/311 (33%), Gaps = 48/311 (15%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP + + T L C G P P V W+ +G++L+ + ++L
Sbjct: 2571 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 2630
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
+ +D+ ++ C SN G + +Y V + D + + P ++
Sbjct: 2631 LLTAPGPQDSAQFECVVSNEVGE---AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTC 2687
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA------------- 433
T IP AQ SP+ L+ PI A
Sbjct: 2688 HSTG---IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2744
Query: 434 -----------APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+PV + + A + V+ C G P P + W +EG + +
Sbjct: 2745 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ 2804
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR-------GN 535
+L L IA ED+G + C A N G+ +L V+ G
Sbjct: 2805 VLPGG-----------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL 2853
Query: 536 EDLSNNGSLHS 546
DLS H+
Sbjct: 2854 PDLSTTEGSHA 2864
Score = 37.7 bits (86), Expect = 0.073
Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 5/71 (7%)
Query: 290 CIVVGIPPPQVRWYC--EGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
C G P PQV W + L P + +++ G+L +++ A D+G Y C A+N
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPA---DSGDYECQATNEV 80
Query: 348 GTDSTSAEIYI 358
G+ S A++ +
Sbjct: 81 GSTSRRAKLVV 91
Score = 35.4 bits (80), Expect = 0.36
Identities = 28/77 (36%), Positives = 39/77 (50%), Gaps = 9/77 (11%)
Query: 456 CRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTC 515
C G P P+V W R+G P L +P +A EE +L +A V DSG + C
Sbjct: 24 CGTHGTPKPQVTW-RKG------PSSEPLHGQP-GVAVLEE-GSLFLASVSPADSGDYEC 74
Query: 516 TASNKYGTVSSIAQLHV 532
A+N+ G+ S A+L V
Sbjct: 75 QATNEVGSTSRRAKLVV 91
Score = 34.3 bits (77), Expect = 0.81
Identities = 50/269 (18%), Positives = 98/269 (36%), Gaps = 37/269 (13%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V + C V G PP V W +G L S + G+ H+L I++ D G ++C
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ--RTLLHGSGHTLRISKVQLADAGIFTCV 2194
Query: 343 ASNIYGTDSTSAEIYIEG---VSSSDSEGDPNKEEMNRIQKPNEVSSPPTT--------S 391
A++ G + + ++ + + + D + ++ P E P
Sbjct: 2195 AASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGE 2254
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK-----PIIAAPVFTKMLQ--NL 444
++ ++ Q L + A S + + + ++ P Q L
Sbjct: 2255 PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTEL 2314
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
S + G + C +G P P + W+++G + + E T V+
Sbjct: 2315 SLTPGAPMELLCDAQGTPQPNITWHKDGQAL--------------TRLENNSRATRVLR- 2359
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
D+G +TC A + G + ++ V+
Sbjct: 2360 --VRDAGLYTCLAESPAGAIEKSFRVRVQ 2386
Score = 31.2 bits (69), Expect = 6.9
Identities = 11/33 (33%), Positives = 18/33 (54%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLI 475
N+S GQ + EC G P P++ W ++ L+
Sbjct: 105 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137
Score = 30.8 bits (68), Expect = 9.0
Identities = 24/92 (26%), Positives = 41/92 (44%), Gaps = 13/92 (14%)
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRER-ISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
C G P P W+K + P + +++ ++ + L + +D+G Y A NE
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGS----LFLASVSPADSGDYECQATNE 79
Query: 1252 AGIVSCTARLDIYAQWHHQIPPPMSVRPSGSR 1283
G S A+L +Y +PP S+R G +
Sbjct: 80 VGSTSRRAKLVVY------VPP--SIREDGRK 103
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 108 bits (269), Expect = 4e-23
Identities = 93/338 (27%), Positives = 135/338 (39%), Gaps = 54/338 (15%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P+ + L TEGS CK G P P + W KDG+ +S ++ G+
Sbjct: 4036 VPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE--- 4092
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERD 1062
L +++ D G YT A N GR HL + LP+
Sbjct: 4093 -LLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV--------------------- 4130
Query: 1063 KEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKML 1122
F PGD G L C G P P + W +N +PV S
Sbjct: 4131 ------------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS---- 4174
Query: 1123 VRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL-EKLQNC 1181
+ G +L +++ D+GTY C A N+ G+ +V VK+APV+ E
Sbjct: 4175 -EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ-----AVSFVHVKEAPVLQGEAFSYL 4228
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
P G ++L+C V G P P +W KD + + R HQ G L I ++ DA
Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLR---HQLQNG--SLTIHRTERDDA 4283
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQI-PPPMSVR 1278
G Y A+NE G+ L + + Q+ P M+VR
Sbjct: 4284 GRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVR 4321
Score = 99.0 bits (245), Expect = 3e-20
Identities = 95/342 (27%), Positives = 133/342 (38%), Gaps = 71/342 (20%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQIS---------------KRNEHCKMRREGDGTCS 1003
G +T C G PVP++ W KD + + + H ++ EG S
Sbjct: 1315 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGH-RLLDEGQ---S 1370
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDK 1063
LH D G Y+ A N G HL+V + P S G QE
Sbjct: 1371 LHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP----------SVLGAGAAQE--- 1417
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
++ G L C SG+P P++ W + QPVLP H + V
Sbjct: 1418 ------------------VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPH-LQV 1458
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI--LEKLQNC 1181
+E G L I D G Y+C+A + GQ + +L V A P I +
Sbjct: 1459 QEDG-QVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA-----PPTIWGSNETGEV 1512
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
V E H V+L C G+P P W KD +P + + + T G L + A+ SDA
Sbjct: 1513 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVY----TRGGRQLQLGRAQSSDA 1568
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSR 1283
G YT A N G RLD+Y +PP ++ +G R
Sbjct: 1569 GVYTCKASNAVGAAEKATRLDVY------VPP--TIEGAGGR 1602
Score = 99.0 bits (245), Expect = 3e-20
Identities = 87/319 (27%), Positives = 132/319 (41%), Gaps = 56/319 (17%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
GSP+ TC + G+P P V W KD + H + R G L + G YT
Sbjct: 3139 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGG----RLQLSRLQPAQAGTYT 3194
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N Q V ++ + R+ S+G + R H +
Sbjct: 3195 CVAENTQAEARKD---FVVAVLVAPRIRSSGVA--------------------REHHVL- 3230
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD-ASHKMLVRETGVHSLLIDPLT 1137
EG+ RLDC+ G PPP++ WL +G P+ D H + G SL++ L
Sbjct: 3231 -------EGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLR 3281
Query: 1138 QRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP---VRLECR 1194
DAG Y C+A N G+++ ++V+ P I + G P V + C
Sbjct: 3282 ASDAGAYTCVAHNPAGEDARLHTVNVLV-----PPTIKQGADGSGTLVSRPGELVTMVCP 3336
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
V G PP W KD +P + +R +H +G+ L I + +DAG +T A + AG+
Sbjct: 3337 VRGSPPIHVSWLKDGLPLPLS-QRTLLH--GSGHT-LRISKVQLADAGIFTCVAASPAGV 3392
Query: 1255 VSCTARLDIYAQWHHQIPP 1273
L + Q+PP
Sbjct: 3393 ADRNFTLQV------QVPP 3405
Score = 95.9 bits (237), Expect = 2e-19
Identities = 85/315 (26%), Positives = 128/315 (40%), Gaps = 48/315 (15%)
Query: 943 IAPIFDKRLKH-FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGT 1001
+AP+F R H V EG P + +C+ G+P PK+ W KDG+ + E ++
Sbjct: 2160 VAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLP--GEGAGLQHVSAVG 2217
Query: 1002 CSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQER 1061
L++ +G YT +N G S L V P AG
Sbjct: 2218 RLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP-----QIAGP----------- 2261
Query: 1062 DKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKM 1121
+EP P + + + L+C +G PPP +TW +GQPV A +
Sbjct: 2262 -REP-------------PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV--GAELGL 2305
Query: 1122 LVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNC 1181
++ G SL ++ G Y C+A N G+ ELSV+ L+ L N
Sbjct: 2306 QLQNQG-QSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD--LDPLTNI 2362
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDT---TGYACLLIQPAKK 1238
P+ L C +G+PPP W + E +S +DT G L + ++
Sbjct: 2363 TAALHSPLTLLCEAMGIPPPAIRWFRGEEP-------VSPGEDTYLLAGGWMLKMTQTQE 2415
Query: 1239 SDAGWYTLSAKNEAG 1253
D+G Y+ A NEAG
Sbjct: 2416 QDSGLYSCLASNEAG 2430
Score = 94.0 bits (232), Expect = 9e-19
Identities = 85/300 (28%), Positives = 113/300 (37%), Gaps = 50/300 (16%)
Query: 954 FRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDD 1013
F VT +PV TC GIP P V W K G Q+ R ++ G +L I
Sbjct: 3866 FTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG----ALEIGQALPIH 3921
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G YT A N G L VQ+ P+ L S ++
Sbjct: 3922 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA---------------------- 3959
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
VA E L L C+ SG+P P +TW G V S ++L L I
Sbjct: 3960 ---------VAEEEVL--LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGG----QLRI 4004
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
+ DAG Y CIA N G L V + PVI L + EG L C
Sbjct: 4005 AHASPEDAGNYLCIAKNSAGSAMGKTRLVV-----QVPPVIENGLPDLSTTEGSHAFLPC 4059
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ G P P W KD + + + ++ LL++ + DAG YT +A+N G
Sbjct: 4060 KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGE----LLVKNLEGQDAGTYTCTAENAVG 4115
Score = 93.2 bits (230), Expect = 1e-18
Identities = 86/298 (28%), Positives = 119/298 (39%), Gaps = 46/298 (15%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V E + VT C G+P P V WFK + +S + DG L IE D G
Sbjct: 1897 VLENASVTLECLASGVPPPDVSWFKGHQPVS---SWMGVTVSVDGRV-LRIEQAQLSDAG 1952
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+Y +A+N G L V ++P R L +
Sbjct: 1953 SYRCVASNVAGSTELRYGLRV-NVPPRITLPPS--------------------------- 1984
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
PG ++ + RL C +G P P L WL +G PV P + + V G L +
Sbjct: 1985 --LPGPVLVNTP--VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG-RVLTLAS 2039
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
D+G Y C+A + G++ + L +V P IL + N V V LEC+
Sbjct: 2040 ARASDSGRYSCVAVSAVGEDRQDVVL-----QVHMPPSILGEELNVSVVANESVALECQS 2094
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
MPPPV W KD + R + + D A L + A DAG YT A N+AG
Sbjct: 2095 HAMPPPVLSWWKDGRPLE-PRPGVHLSADK---ALLQVDRADVWDAGHYTCEALNQAG 2148
Score = 92.8 bits (229), Expect = 2e-18
Identities = 92/360 (25%), Positives = 143/360 (39%), Gaps = 66/360 (18%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
SP+T C+ +GIP P + WF+ + +S + + G L + T D G Y+
Sbjct: 2368 SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLA----GGWMLKMTQTQEQDSGLYSC 2423
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
+A+N G + + V P ++ D E +
Sbjct: 2424 LASNEAGEARRNFSVEVLVPP----------------SIENEDLEEV------------- 2454
Query: 1080 GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQR 1139
+ +G+ L C V+G P P+LTW +G+P+ +H + GV L +
Sbjct: 2455 --IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHH--ISPDGV-LLQVLQANLS 2509
Query: 1140 DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCG-----VPEGHPVRLECR 1194
AG Y CIA N G+ + +LSV+ AP IL ++ V +P+ L C
Sbjct: 2510 SAGHYSCIAANAVGEKTKHFQLSVLL-----APTILGGAEDSADEEVTVTVNNPISLICE 2564
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
+ P P W KD +R I + T G L I A+K DAG YT NE G
Sbjct: 2565 ALAFPSPNITWMKDGAPFEASR-NIQLLPGTHG---LQILNAQKEDAGQYTCVVTNELG- 2619
Query: 1255 VSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSV 1314
+ +H ++ P PS S+ L G + + + ST+ C S +V
Sbjct: 2620 -------EAVKNYHVEVLIP----PSISKDDPLGEVG--VKEVKTKVNSTLTLECESWAV 2666
Score = 90.5 bits (223), Expect = 1e-17
Identities = 84/334 (25%), Positives = 147/334 (44%), Gaps = 41/334 (12%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P+ + +K + S +T C+ +P P + W+KDG+ ++ + +++ G+G L
Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSS---RLQVLGEGRL-L 2695
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I+ T D G Y +A N G ++++Q P+ ++ + SR +E
Sbjct: 2696 QIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGG 2755
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVR 1124
+ R ++V E L C + +PPP+LTW QP+ A ++ V
Sbjct: 2756 VTEYR-----------EIV--ENNPAYLYCDTNAIPPPDLTWYREDQPL--SAGDEVSVL 2800
Query: 1125 ETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVIL----EKLQN 1180
+ G L I + +AG Y C A+N+ G++ EL V+ PVIL E ++
Sbjct: 2801 QGG-RVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT-----PPVILGDTEELVEE 2854
Query: 1181 CGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCT-RERISMHQDTTGYACLLIQPAKKS 1239
V V L+C +G P P W ++ +P + R+ + +D L + A+ +
Sbjct: 2855 VTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDG---QVLQVSTAEVA 2909
Query: 1240 DAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPP 1273
DA Y A+N+AG L + Q+PP
Sbjct: 2910 DAASYMCVAENQAGSAEKLFTLRV------QVPP 2937
Score = 90.1 bits (222), Expect = 1e-17
Identities = 77/303 (25%), Positives = 120/303 (39%), Gaps = 45/303 (14%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+V +G C + G P PK+ WFKDG+ +++ + H DG L +
Sbjct: 2456 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVL-LQVLQANLSSA 2511
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G+Y+ +AAN G + L V P G V P+
Sbjct: 2512 GHYSCIAANAVGEKTKHFQLSVLLAP----TILGGAEDSADEEVTVTVNNPIS------- 2560
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
L C+ P P +TW+ +G P + ++L G H L I
Sbjct: 2561 -----------------LICEALAFPSPNITWMKDGAPFEASRNIQLL---PGTHGLQIL 2600
Query: 1135 PLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ DAG Y C+ TN+ G+ ++ +E+ + K P+ ++ + LE
Sbjct: 2601 NAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLE 2660
Query: 1193 CRVIGMPPPVFYWKKDNETI-PCTRERISMHQDTTGYACLL-IQPAKKSDAGWYTLSAKN 1250
C +PPP W KD + + P +R ++ G LL IQP + SD+G Y A N
Sbjct: 2661 CESWAVPPPTIRWYKDGQPVTPSSRLQV------LGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 1251 EAG 1253
AG
Sbjct: 2715 VAG 2717
Score = 88.6 bits (218), Expect = 4e-17
Identities = 89/344 (25%), Positives = 127/344 (36%), Gaps = 53/344 (15%)
Query: 925 VDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFK-DGK 983
V+E D ++ G AP + + V G C+ G P P V W + DG+
Sbjct: 768 VNELGDASAEIQLAVGH--APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 825
Query: 984 QISKR---NEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ R + R+ G L ES +D Y A N G++ L+V
Sbjct: 826 PLGLRLGAGRGSRSRQPDSGV--LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG-- 881
Query: 1041 IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKV-SGL 1099
P + + EG+ L C V +G
Sbjct: 882 -----------------------------HAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 912
Query: 1100 PPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL 1159
P PE WL +G+P+ P + H +R G SL +D Q AG Y C+ATN G +
Sbjct: 913 PLPERHWLKDGRPLPPGSRHS--IRADG--SLHLDRALQEHAGRYSCVATNTAGSQHRDV 968
Query: 1160 ELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
EL VV + P + N EG P L C G+P P W K+ +
Sbjct: 969 EL-VVQVPPRIHPTATHHITN----EGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 1023
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
++ ++ T LLI DAG Y +A N G S RL +
Sbjct: 1024 NVSKEGT----LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 88.6 bits (218), Expect = 4e-17
Identities = 98/399 (24%), Positives = 152/399 (38%), Gaps = 99/399 (24%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISK-RNEHCKMRREGDGTCSLHIESTT 1010
+ V EG V C+ G P P V W KDG + + H + +G SL ++
Sbjct: 3225 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG---SLVLKGLR 3281
Query: 1011 SDDDGNYTIMAANPQGR-------------------------ISCSGHLMVQSLPIRS-- 1043
+ D G YT +A NP G +S G L+ P+R
Sbjct: 3282 ASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP 3341
Query: 1044 -----------------RLTSAGQSHRGR-SRVQERDK----------EPLQERFFRPHF 1075
R G H R S+VQ D + +R F
Sbjct: 3342 PIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV 3401
Query: 1076 LQAP--------GDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
P D+V G L L C+ G+P P ++W+ +G+P+L + E G
Sbjct: 3402 QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS------LEQG 3455
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ--NCGVPE 1185
SL ++ + D+GTY C+A ++ G+ +L+V+ + P I + Q +
Sbjct: 3456 -PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM-----EPPHIEDSGQPTELSLTP 3509
Query: 1186 GHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
G P+ L C G P P W KD + + R+ + T + + DAG YT
Sbjct: 3510 GAPMELLCDAQGTPQPNITWHKDGQAL----TRLENNSRAT-------RVLRVRDAGLYT 3558
Query: 1246 LSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRY 1284
A++ AG + + R+ + A PP V P G R+
Sbjct: 3559 CLAESPAGAIEKSFRVRVQA-------PPNIVGPRGPRF 3590
Score = 87.4 bits (215), Expect = 8e-17
Identities = 79/300 (26%), Positives = 116/300 (38%), Gaps = 58/300 (19%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+T G+P+ C G P P + W KDG+ +++ + + R L + D G
Sbjct: 3507 LTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRV------LRVR-----DAG 3555
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT +A +P G I S + VQ+ P + V R P F
Sbjct: 3556 LYTCLAESPAGAIEKSFRVRVQAPP---------------NIVGPRG----------PRF 3590
Query: 1076 LQ--APGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
+ APG +V L+C V P P++TW +G + DA + R L +
Sbjct: 3591 VVGLAPGQLV--------LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERG---RFLQL 3639
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLEC 1193
L+ D+G Y C A N G S + + E+ P I V L C
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRV-----EIHTVPTIRSGPPAVNVSVNQTALLPC 3694
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
+ G+P P+ W+KD + R + + L IQP DAG Y A N AG
Sbjct: 3695 QADGVPAPLVSWRKDRVPLDPRSPRFEILPE----GSLRIQPVLAQDAGHYLCLASNSAG 3750
Score = 85.1 bits (209), Expect = 4e-16
Identities = 84/328 (25%), Positives = 124/328 (37%), Gaps = 64/328 (19%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V +PV TC G P P + W KDG +S G +L S + D G
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTL--ASARASDSG 2046
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ +A + G R Q H S + E
Sbjct: 2047 RYSCVAVSAVGE---------------DRQDVVLQVHMPPSILGE--------------- 2076
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHS----- 1130
+ +VA+E L+C+ +PPP L+W +G+P+ P GVH
Sbjct: 2077 -ELNVSVVANES--VALECQSHAMPPPVLSWWKDGRPLEP---------RPGVHLSADKA 2124
Query: 1131 -LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVI-LEKLQNCGVPEGHP 1188
L +D DAG Y C A N+ G + L+V APV L + V EGHP
Sbjct: 2125 LLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWV-----APVFPLRESHTLTVREGHP 2179
Query: 1189 VRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSA 1248
L C G+P P W+KD + +P E + + L + A+ + G YT
Sbjct: 2180 TSLSCECRGVPFPKISWRKDGQPLP--GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 2237
Query: 1249 KNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
N G S +L+++ +PP ++
Sbjct: 2238 SNVVGNSSQDLQLEVH------VPPQIA 2259
Score = 83.2 bits (204), Expect = 2e-15
Identities = 87/341 (25%), Positives = 125/341 (36%), Gaps = 62/341 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G C+ G+P P+V W++ G ++ + EG + L I + D G
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMI-------LAPEGSSSGKLRIPAAQERDAG 761
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT A N G S L V P + L
Sbjct: 762 TYTCRAVNELGDASAEIQLAVGHAPQLTEL------------------------------ 791
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLL-NGQP--VLPDASHKMLVRETGVHSLL 1132
P D+ GR L C+ +G PPP +TW +GQP + A R+ L
Sbjct: 792 ---PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF 848
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ + D Y C A N G+ L V P I V EG PV L
Sbjct: 849 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTG---HAPPQIASSAPTVRVLEGQPVSLP 905
Query: 1193 CRVI-GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
C V+ G P P +W KD +P R S+ D L + A + AG Y+ A N
Sbjct: 906 CIVLAGRPLPERHWLKDGRPLP-PGSRHSIRAD----GSLHLDRALQEHAGRYSCVATNT 960
Query: 1252 AGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGL 1292
AG L + Q+PP + P+ + + +T++G+
Sbjct: 961 AGSQHRDVELVV------QVPP--RIHPTATHH--ITNEGV 991
Score = 82.8 bits (203), Expect = 2e-15
Identities = 82/340 (24%), Positives = 137/340 (40%), Gaps = 57/340 (16%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G+ V C G+P P+V W KD + + H +++ +G L I + D+G Y
Sbjct: 1423 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ---VLRITGSHVGDEGRYQ 1479
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A +P G+ + L V + P T G +
Sbjct: 1480 CVAFSPAGQQARDFQLRVHAPP-----TIWGSNE-------------------------- 1508
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
G++ E L +L C+ G+P P +TW +G +LP ++ + R G L +
Sbjct: 1509 TGEVAVMEDHLVQLLCEARGVPTPNITWFKDG-ALLPTSTKVVYTR--GGRQLQLGRAQS 1565
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKA---PVILEKLQNCGVPEGHPVRLECR 1194
DAG Y C A+N G + L V V ++ A P +++ + G PV LEC
Sbjct: 1566 SDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV------AGRPVALECV 1619
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G P P W +E +P S +T G L P + S +G Y+ A + AG
Sbjct: 1620 ARGHPSPTLSW--HHEGLPVAESNES-RLETDGSVLRLESPGEAS-SGLYSCVASSPAGE 1675
Query: 1255 VSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDI 1294
+++ Q+PP + V + ++ + L++
Sbjct: 1676 AVLQYSVEV------QVPPQLLVAEGLGQVTTIVGQPLEL 1709
Score = 82.8 bits (203), Expect = 2e-15
Identities = 74/312 (23%), Positives = 116/312 (37%), Gaps = 44/312 (14%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V E V C+ G+P P + WFKDG + + R G L + S D G
Sbjct: 1514 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTR----GGRQLQLGRAQSSDAG 1569
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT A+N G + L V P + AG RP+
Sbjct: 1570 VYTCKASNAVGAAEKATRLDVYVPP---TIEGAGG---------------------RPYV 1605
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++A GR L+C G P P L+W G PV ++ ET L ++
Sbjct: 1606 VKAVA------GRPVALECVARGHPSPTLSWHHEGLPVAESNESRL---ETDGSVLRLES 1656
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
+ +G Y C+A++ G+ + V +V ++ E L G P+ L C+
Sbjct: 1657 PGEASSGLYSCVASSPAGEAVLQYSVEV---QVPPQLLVAEGLGQVTTIVGQPLELPCQA 1713
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G P P W ++ E ++ Q + L I + +G + A NEAG
Sbjct: 1714 SGSPVPTIQWLQNGR----PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA 1769
Query: 1256 SCTARLDIYAQW 1267
+ ++ +W
Sbjct: 1770 GAEVEVSVHGEW 1781
Score = 82.4 bits (202), Expect = 3e-15
Identities = 87/375 (23%), Positives = 141/375 (37%), Gaps = 55/375 (14%)
Query: 933 QHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
QH ++ + P H EG P + C G+P P + W K+ ++ R H
Sbjct: 964 QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 1023
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSR------LT 1046
+ +EG +L I ++ D G Y A N G S L V L + L
Sbjct: 1024 NVSKEG----TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL 1079
Query: 1047 SAGQSHRGRSRVQERD------KEPLQERFFR--------PHFLQAPGDMVAHEGRLCRL 1092
+G + +V + P R P P + G L
Sbjct: 1080 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDL 1139
Query: 1093 DCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKT 1152
+C G P P+L+W +G VL + V + + DAG Y+C A+N
Sbjct: 1140 NCVAEGNPEPQLSWSKDGV-VLQGRGPQGSVHFAAIRT--------SDAGRYRCEASNSA 1190
Query: 1153 GQNSFSLELSVVAKE---VKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDN 1209
G +++ +EL V+ + +LE++ G L C G P P W+K
Sbjct: 1191 GVDAWEVELRVLEPPHWGADETSGLLERV------AGENASLPCPARGTPKPQVTWRKGP 1244
Query: 1210 ETIPC-TRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWH 1268
+ P + +++ ++ L + +D+G Y A NE G S A+L +Y
Sbjct: 1245 SSEPLHGQPGVAVLEE----GSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVY---- 1296
Query: 1269 HQIPPPMSVRPSGSR 1283
+PP S+R G +
Sbjct: 1297 --VPP--SIREDGRK 1307
Score = 81.3 bits (199), Expect = 6e-15
Identities = 79/318 (24%), Positives = 121/318 (38%), Gaps = 65/318 (20%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
+HF ++G V +C G P P + W ++ + + E ++ + GT L I+
Sbjct: 617 QHF--SQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIHVDAQGT--LIIQGVAP 669
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071
+D GNY+ A N G D+E + +
Sbjct: 670 EDAGNYSCQATNEVGT----------------------------------DQETVTLYYT 695
Query: 1072 RPHFLQAPGDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVL--PDASHKMLVRETGV 1128
P + A +V G L C+ SG+PPP + W G ++ P+ S +R
Sbjct: 696 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLR---- 751
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
I +RDAGTY C A N+ G S ++L+ V AP + E ++ V G
Sbjct: 752 ----IPAAQERDAGTYTCRAVNELGDASAEIQLA-----VGHAPQLTELPRDVTVELGRS 802
Query: 1189 VRLECRVIGMPPPVFYWKKDNE-----TIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
L CR G PPP W++ + + R S D+ L + D
Sbjct: 803 ALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS---GVLFFESVAPEDQAP 859
Query: 1244 YTLSAKNEAGIVSCTARL 1261
Y A+N G V ARL
Sbjct: 860 YVCEARNVFGKVQAEARL 877
Score = 75.5 bits (184), Expect = 3e-13
Identities = 75/310 (24%), Positives = 120/310 (38%), Gaps = 30/310 (9%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+ P+ + S+ +G V++ C G P P + W E + L+ IH+ G +L
Sbjct: 606 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TL 662
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDS----------EGDPNKEEMN 376
I ED G YSC A+N GTD + +Y S + E E +
Sbjct: 663 IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 722
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHL---VAQPRVATIQQCQSPTNYLQGLDGKPIIA 433
+ P + ++ P + L AQ R A C++ N L + +A
Sbjct: 723 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELGDASAEIQLA 781
Query: 434 ---APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS 490
AP T++ ++++ G+ + CR G P P V W R + P L S
Sbjct: 782 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRG----DGQPLGLRLGAGRGS 837
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANST 550
+ + L V ED + C A N +G V + A+L V G + A+S
Sbjct: 838 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG------HAPPQIASSA 891
Query: 551 TNLAAIEPQP 560
+ +E QP
Sbjct: 892 PTVRVLEGQP 901
Score = 75.1 bits (183), Expect = 4e-13
Identities = 81/342 (23%), Positives = 130/342 (38%), Gaps = 62/342 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+ E +P C IP P + W+++ + +S +E ++ G L I +++ G
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQ----GGRVLQIPLVRAENAG 2817
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ A+N G L+V + P+ D E L E
Sbjct: 2818 RYSCKASNEVGEDWLHYELLVLTPPVILG-----------------DTEELVE------- 2853
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
++ + L C G P P ++WL NG P P S ++ V E G L +
Sbjct: 2854 -----EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDG-QVLQVST 2905
Query: 1136 LTQRDAGTYKCIATNKTG--QNSFSLELSVVAK----EVKKAPVILEKLQNCGVPEGHPV 1189
DA +Y C+A N+ G + F+L + V + ++++ IL V
Sbjct: 2906 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS----------SV 2955
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
L C V P P W KD++ + E + G L + A+ SD+G YT A
Sbjct: 2956 SLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL----PGTHTLQLGRARLSDSGMYTCEAL 3011
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKG 1291
N AG +L + +PP P G + L G
Sbjct: 3012 NAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVG 3047
Score = 74.3 bits (181), Expect = 7e-13
Identities = 71/292 (24%), Positives = 115/292 (39%), Gaps = 53/292 (18%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C+ G+P P V W KD + R+ ++ EG SL I+ + D G+Y +A+N
Sbjct: 3694 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG----SLRIQPVLAQDAGHYLCLASN-- 3747
Query: 1026 GRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAH 1085
SAG +GR R EP P +P ++
Sbjct: 3748 ---------------------SAGSDRQGRDL---RVLEP-------PAIAPSPSNLTLT 3776
Query: 1086 EGRLCRLDCKVSGLPPPELTWLLNGQPV---LPDASHKMLVRETGVHSLLIDPLTQRDAG 1142
L C+ SG P P + W +GQ + L ++++L ++LL+ +D+
Sbjct: 3777 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS----NALLLTAPGPQDSA 3832
Query: 1143 TYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPV 1202
++C+ +N+ G+ +++ V P I + + V PV L C G+P P
Sbjct: 3833 QFECVVSNEVGEAHRLYQVT-----VHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT 3887
Query: 1203 FYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
W K + + L I A AG YT SA+N AG+
Sbjct: 3888 VSWSKAGAQLGARGSGYRVSPS----GALEIGQALPIHAGRYTCSARNSAGV 3935
Score = 73.9 bits (180), Expect = 9e-13
Identities = 76/292 (26%), Positives = 109/292 (37%), Gaps = 46/292 (15%)
Query: 960 SPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTI 1019
S V+ C + P P+V W+KD + +S E + GT +L + D G YT
Sbjct: 2953 SSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL----PGTHTLQLGRARLSDSGMYTC 3008
Query: 1020 MAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAP 1079
A N GR L V P + Q+ RG P
Sbjct: 3009 EALNAAGRDQKLVQLSVLVPP------AFRQAPRG------------------------P 3038
Query: 1080 GDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
D V G L C+ LP P +TW +GQP++ + L G L I
Sbjct: 3039 QDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQAL---RGGQRLEIQEAQV 3095
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
D G Y C +N G+ + L+V + P K + G P+ L C V G+
Sbjct: 3096 SDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCDVSGV 3151
Query: 1199 PPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKN 1250
P P W KD + E ++H + L + + + AG YT A+N
Sbjct: 3152 PAPTVTWLKDRMPV----ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN 3199
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/289 (22%), Positives = 114/289 (39%), Gaps = 49/289 (16%)
Query: 966 CKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQ 1025
C + P PK+ W +DG + + + H + G L +++ ++ D G+Y+ A N
Sbjct: 3603 CSVEAEPAPKITWHRDGI-VLQEDAHTQFPERGR---FLQLQALSTADSGDYSCTARNAA 3658
Query: 1026 GRISCSGHLMVQSLP-IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVA 1084
G S + + + ++P IRS P +
Sbjct: 3659 GSTSVAFRVEIHTVPTIRS----------------------------------GPPAVNV 3684
Query: 1085 HEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTY 1144
+ L C+ G+P P ++W + P+ P + ++ E SL I P+ +DAG Y
Sbjct: 3685 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHY 3741
Query: 1145 KCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFY 1204
C+A+N G + +L V+ + P I N + P L C G P P+
Sbjct: 3742 LCLASNSAGSDRQGRDLRVL-----EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVV 3796
Query: 1205 WKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
W KD + + R + ++ A LL P + D+ + NE G
Sbjct: 3797 WWKDGQKLD-FRLQQGAYRLLPSNALLLTAPGPQ-DSAQFECVVSNEVG 3843
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/231 (26%), Positives = 104/231 (45%), Gaps = 26/231 (11%)
Query: 1046 TSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELT 1105
T+ ++ GR++ Q +P + P+ +PG+ L C+V G P LT
Sbjct: 497 TAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAV-------LSCRVLGEAPYNLT 549
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W+ + + VLP ++ + V + SL I + D G Y+C+A+N G S+ L V
Sbjct: 550 WVRDWR-VLPASTGR--VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV-- 604
Query: 1166 KEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDT 1225
++AP + + +G V++ C G P P W ++++ + +E +H D
Sbjct: 605 ---REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL---QEDSRIHVDA 658
Query: 1226 TGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
G L+IQ DAG Y+ A NE G T L ++ PP +S
Sbjct: 659 QG--TLIIQGVAPEDAGNYSCQATNEVGTDQETVTL------YYTDPPSVS 701
Score = 73.2 bits (178), Expect = 2e-12
Identities = 80/328 (24%), Positives = 125/328 (38%), Gaps = 67/328 (20%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V GS V C+ G+P+P V W KDG+ + ++ +G SL +E+ + D G
Sbjct: 3418 VVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS-----LEQGP---SLQLEAVGAGDSG 3469
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y+ +A + G L V P + +GQ
Sbjct: 3470 TYSCVAVSEAGEARRHFQLTVMEPP---HIEDSGQ------------------------- 3501
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
P ++ G L C G P P +TW +GQ + ++ R V
Sbjct: 3502 ---PTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV------- 3551
Query: 1136 LTQRDAGTYKCIATNKTG--QNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLE 1192
RDAG Y C+A + G + SF + + V + P + G+ G V LE
Sbjct: 3552 ---RDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFV-----VGLAPGQLV-LE 3602
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C V P P W +D + + + Q L +Q +D+G Y+ +A+N A
Sbjct: 3603 CSVEAEPAPKITWHRDGIVL----QEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 3658
Query: 1253 GIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
G S R++I H +P S P+
Sbjct: 3659 GSTSVAFRVEI-----HTVPTIRSGPPA 3681
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/195 (28%), Positives = 78/195 (40%), Gaps = 42/195 (21%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G + C + G PVP ++W KDG + R H + + + SL I T DD G Y
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPL--RGSHLRHQLQNG---SLTIHRTERDDAGRYQ 4287
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
+A N G L++QS P+ F
Sbjct: 4288 CLAENEMGVAKKVVILVLQSAPV---------------------------------FQVE 4314
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
P DM G L C+ +G P P + WL GQP+ AS ++ G SL ++ +
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL--RASRRLRTLPDG--SLWLENVET 4370
Query: 1139 RDAGTYKCIATNKTG 1153
DAGTY C+A N G
Sbjct: 4371 GDAGTYDCVAHNLLG 4385
Score = 71.2 bits (173), Expect = 6e-12
Identities = 75/310 (24%), Positives = 113/310 (36%), Gaps = 57/310 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V+ G +C+++G + W +D + + + SL I D G
Sbjct: 528 VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD----LSLEISGIIPTDGG 583
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y +A+N G S L+V+ P S TS+ HF
Sbjct: 584 RYQCVASNANGVTRASVWLLVREAPQVSIHTSS------------------------QHF 619
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
Q G ++ C SG P P ++W Q + D+ + + T L+I
Sbjct: 620 SQ---------GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT----LIIQG 666
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA--PVILEKLQNCGVPEGHPVRLEC 1193
+ DAG Y C ATN+ G + ++ L A V+L V G L C
Sbjct: 667 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL-------VAVGEEAVLVC 719
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
G+PPP W + + E S + L I A++ DAG YT A NE G
Sbjct: 720 EASGVPPPRVIWYRGGLEMILAPEGSSSGK-------LRIPAAQERDAGTYTCRAVNELG 772
Query: 1254 IVSCTARLDI 1263
S +L +
Sbjct: 773 DASAEIQLAV 782
Score = 70.9 bits (172), Expect = 8e-12
Identities = 67/320 (20%), Positives = 125/320 (39%), Gaps = 59/320 (18%)
Query: 256 PSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI 315
P S+ ++PLG+ ++ + + + L+C +PPP +RWY +G+ + S +
Sbjct: 2632 PPSISKDDPLGEVG-----VKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 2686
Query: 316 HIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE---------------G 360
++ G L L I D+GRY C A+N+ G D + I+
Sbjct: 2687 QVLGEGRL--LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFE 2744
Query: 361 VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVP---QAQHLVAQPRVATIQ--- 414
+ S + E E I + N T+A+ PP + + Q L A V+ +Q
Sbjct: 2745 ILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGR 2804
Query: 415 ---------------QCQSPTN------YLQGLDGKPIIAAPVFTKMLQNLSASEGQLVV 453
C++ + + L P + ++++ ++ + V
Sbjct: 2805 VLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVS 2864
Query: 454 FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
+C G P P + W + G SP ++L E ++ + AEV D+ +
Sbjct: 2865 LQCPALGNPVPTISWLQNGLPFSPSPRLQVL--------EDGQVLQVSTAEV--ADAASY 2914
Query: 514 TCTASNKYGTVSSIAQLHVR 533
C A N+ G+ + L V+
Sbjct: 2915 MCVAENQAGSAEKLFTLRVQ 2934
Score = 69.7 bits (169), Expect = 2e-11
Identities = 67/278 (24%), Positives = 111/278 (39%), Gaps = 35/278 (12%)
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
RE+ E L C IPPP + WY E + L ++ ++Q G + + + A E+ G
Sbjct: 2760 REIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRA--ENAG 2817
Query: 338 RYSCFASNIYGTDSTSAEIYI--EGVSSSDSEGDPNKEEMN-----RIQKPNEVSSPPTT 390
RYSC ASN G D E+ + V D+E + +N +Q P + PT
Sbjct: 2818 RYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTI 2877
Query: 391 SAV---IPPAVPQAQHLVAQPRVATIQQCQ--SPTNYLQGLDGKPIIAAPVFTKM----- 440
S + +P + ++ +V + + +Y+ + + A +FT
Sbjct: 2878 SWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPP 2937
Query: 441 ------LQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEP 494
L+ ++A V C V P+P+V WY++ + + +L
Sbjct: 2938 RIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH------ 2991
Query: 495 EEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
TL + DSG +TC A N G + QL V
Sbjct: 2992 ----TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSV 3025
Score = 68.9 bits (167), Expect = 3e-11
Identities = 58/201 (28%), Positives = 80/201 (39%), Gaps = 15/201 (7%)
Query: 1073 PHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLL 1132
P+ P + E L+C SG+PPP+++W QPV +S + L
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPV---SSWMGVTVSVDGRVLR 1942
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
I+ DAG+Y+C+A+N G L V P L V PVRL
Sbjct: 1943 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG----PVLVNTPVRLT 1998
Query: 1193 CRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEA 1252
C G P P W KD P + Q G L + A+ SD+G Y+ A +
Sbjct: 1999 CNATGAPSPTLMWLKDGN--PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 2056
Query: 1253 GIVSCTARLDIYAQWHHQIPP 1273
G R D+ Q H +PP
Sbjct: 2057 G----EDRQDVVLQVH--MPP 2071
Score = 68.6 bits (166), Expect = 4e-11
Identities = 83/325 (25%), Positives = 120/325 (36%), Gaps = 47/325 (14%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G P+ C+ G PVP + W ++G+ E ++ GT +LHI+ D G +
Sbjct: 1704 GQPLELPCQASGSPVPTIQWLQNGRPAE---ELAGVQVASQGT-TLHIDHVELDHSGLFA 1759
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRL-TSAGQSHRGRSRVQERDKEPLQERFFRPHFLQ 1077
A N G + V L GQ H G
Sbjct: 1760 CQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSS---------------FP 1804
Query: 1078 APGDMVAHEGRLCRLDCK-VSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPL 1136
A D H G V G P W G+P ++ + L I+ +
Sbjct: 1805 AACDPPVHRGWGAHPKPPLVEGWCSPGSLW---GEPTGIPVAYSL------PPPLQIEKV 1855
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAPVILEKLQNCGVPEGHPVRLECRV 1195
RD G Y C ATN G++ + L V V ++ PV N V E V LEC
Sbjct: 1856 DLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV------NKAVLENASVTLECLA 1909
Query: 1196 IGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIV 1255
G+PPP W K ++ + +++ D L I+ A+ SDAG Y A N AG
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMG-VTVSVDGR---VLRIEQAQLSDAGSYRCVASNVAGST 1965
Query: 1256 SCTARLDIYAQWHHQIPPPMSVRPS 1280
L + +PP +++ PS
Sbjct: 1966 ELRYGLRV------NVPPRITLPPS 1984
Score = 67.4 bits (163), Expect = 9e-11
Identities = 87/376 (23%), Positives = 134/376 (35%), Gaps = 63/376 (16%)
Query: 948 DKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIE 1007
++ ++ V S V+ C +G PVP + W ++G S + ++ +G L +
Sbjct: 2849 EELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP-SPRLQVLEDGQ---VLQVS 2904
Query: 1008 STTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQ 1067
+ D +Y +A N G L VQ P R+ D E
Sbjct: 2905 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPP----------------RIAGLDLE--- 2945
Query: 1068 ERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETG 1127
+ A L C V P PE+TW + Q + +L G
Sbjct: 2946 -------------QVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL---PG 2989
Query: 1128 VHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV-VAKEVKKAP-----VILEKLQNC 1181
H+L + D+G Y C A N G++ ++LSV V ++AP +L ++
Sbjct: 2990 THTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV--- 3046
Query: 1182 GVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
G L C +P P W KD + + + Q G L IQ A+ SD
Sbjct: 3047 ----GDKAVLSCETDALPEPTVTWYKDGQPLVLAQRT----QALRGGQRLEIQEAQVSDK 3098
Query: 1242 GWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSM 1301
G Y+ N AG T L + Q+PP P + L + S +
Sbjct: 3099 GLYSCKVSNVAGEAVRTFTLTV------QVPPTFE-NPKTETVSQVAGSPLVLTCDVSGV 3151
Query: 1302 ESTMVYSCSSRSVVES 1317
+ V R VES
Sbjct: 3152 PAPTVTWLKDRMPVES 3167
Score = 67.4 bits (163), Expect = 9e-11
Identities = 65/268 (24%), Positives = 103/268 (38%), Gaps = 37/268 (13%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
V L C GIP P + W EG + ++ G L IA A ED G Y C A N
Sbjct: 3965 VLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLR---IAHASPEDAGNYLCIAKN 4021
Query: 346 IYGTDSTSAEIYIE-------GVSS-SDSEGD----PNKEEMNRIQKPN--------EVS 385
G+ + ++ G+ S +EG P K + +PN VS
Sbjct: 4022 SAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGS--PEPNITWDKDGQPVS 4079
Query: 386 SPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFTKMLQNLS 445
+ P ++L Q ++ + I+ PVFT + + S
Sbjct: 4080 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRS 4139
Query: 446 ASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEV 505
G + C +G+P+P++ W + D P ++E + TL A V
Sbjct: 4140 LRLGDRLWLRCAARGSPTPRIGW-----TVNDRP-------VTEGVSEQDGGSTLQRAAV 4187
Query: 506 FAEDSGCFTCTASNKYGTVSSIAQLHVR 533
EDSG + C A N+ G +++ +HV+
Sbjct: 4188 SREDSGTYVCWAENRVGRTQAVSFVHVK 4215
Score = 64.7 bits (156), Expect = 6e-10
Identities = 59/222 (26%), Positives = 90/222 (40%), Gaps = 41/222 (18%)
Query: 955 RVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD 1014
+ G PV C G P P + W +G +++ NE R E DG+ L +ES
Sbjct: 1607 KAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES---RLETDGSV-LRLESPGEASS 1662
Query: 1015 GNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPH 1074
G Y+ +A++P G + VQ P L + G
Sbjct: 1663 GLYSCVASSPAGEAVLQYSVEVQVPP--QLLVAEGL------------------------ 1696
Query: 1075 FLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLID 1134
G + G+ L C+ SG P P + WL NG+P A ++ + T +H ID
Sbjct: 1697 -----GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLH---ID 1748
Query: 1135 PLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILE 1176
+ +G + C ATN+ G +E+SV + AP +LE
Sbjct: 1749 HVELDHSGLFACQATNEAGTAGAEVEVSV---HGEWAPGVLE 1787
Score = 64.3 bits (155), Expect = 7e-10
Identities = 78/329 (23%), Positives = 115/329 (34%), Gaps = 55/329 (16%)
Query: 239 EQAASEAAGGDTTPGSS---PSSLYYEEPLGQPPRFT-QKLRSREVPEGTRVQLDCIVVG 294
EQA AG S+ + L Y + PPR T V T V+L C G
Sbjct: 1944 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATG 2003
Query: 295 IPPPQVRWYCEGKELE--NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDST 352
P P + W +G + +P + + G + LT+A A D+GRYSC A + G D
Sbjct: 2004 APSPTLMWLKDGNPVSPAGTPGLQVFPGGRV--LTLASARASDSGRYSCVAVSAVGEDRQ 2061
Query: 353 SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAV------------PQ 400
+ + S EE+N NE + S +PP V
Sbjct: 2062 DVVLQVHMPPSILG------EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRP 2115
Query: 401 AQHLVAQPRVATIQQCQ------------SPTNYLQGLDGKPIIAAPVF-TKMLQNLSAS 447
HL A + + + + + + + APVF + L+
Sbjct: 2116 GVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVR 2175
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICT----LVIA 503
EG C +G P PK+ W ++G Q P A + + L +
Sbjct: 2176 EGHPTSLSCECRGVPFPKISWRKDG------------QPLPGEGAGLQHVSAVGRLLYLG 2223
Query: 504 EVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+ G +TC SN G S QL V
Sbjct: 2224 QAQLAQEGTYTCECSNVVGNSSQDLQLEV 2252
Score = 62.4 bits (150), Expect = 3e-09
Identities = 72/341 (21%), Positives = 129/341 (37%), Gaps = 50/341 (14%)
Query: 208 RSSVPIPIPADTRDNEVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSSLYYEEPLGQ 267
+ +P+P+ T + H L + + +A AA + + P+ +
Sbjct: 3349 KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLE 3408
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGK-----ELENSPDIHIVQAGN 322
P F + V G+ V+L C G+P P V W +G+ LE P + + G
Sbjct: 3409 PVEFQNDV---VVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVG- 3464
Query: 323 LHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK------EEMN 376
D+G YSC A + G ++ + + G P + M
Sbjct: 3465 ----------AGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPME 3514
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQC-------QSPTNYLQG---- 425
+ P T A+ + ++ RV ++ +SP ++
Sbjct: 3515 LLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRV 3574
Query: 426 -LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P I P + + L+ GQLV+ EC V+ P+PK+ W+R+G ++++ +
Sbjct: 3575 RVQAPPNIVGPRGPRFVVGLAP--GQLVL-ECSVEAEPAPKITWHRDGIVLQEDAHTQF- 3630
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
PE L + + DSG ++CTA N G+ S
Sbjct: 3631 ---------PERGRFLQLQALSTADSGDYSCTARNAAGSTS 3662
Score = 62.0 bits (149), Expect = 4e-09
Identities = 70/286 (24%), Positives = 109/286 (38%), Gaps = 51/286 (17%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V E VQL C G+P P + W+ +G L S + + G L + A D G Y
Sbjct: 1514 VMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG--RQLQLGRAQSSDAGVY 1571
Query: 340 SCFASNIYGT--DSTSAEIY----IEGVSS-----SDSEGDPNKEEMNRIQKPNEVSSPP 388
+C ASN G +T ++Y IEG G P E P+ P
Sbjct: 1572 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS-----P 1626
Query: 389 TTS---AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGL--------DGKPIIAAPVF 437
T S +P A L ++ + +SP GL G+ ++ V
Sbjct: 1627 TLSWHHEGLPVAESNESRLETD---GSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 1683
Query: 438 TKMLQNLSASE---------GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
++ L +E GQ + C+ G+P P ++W + G E+ ++ +
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG- 1742
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
TL I V + SG F C A+N+ GT + ++ V G
Sbjct: 1743 ---------TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779
Score = 60.5 bits (145), Expect = 1e-08
Identities = 71/321 (22%), Positives = 121/321 (37%), Gaps = 44/321 (13%)
Query: 236 REAEQAASEAAGGDTTPGSSPSSLYYEEPLGQ--PPRFTQKLRSREVPEGTRVQLDCIVV 293
R A+ ++ + T + S + LG PP+ R +V G + L+C+
Sbjct: 1085 RLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAE 1144
Query: 294 GIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTS 353
G P PQ+ W +G L+ G++H I + D GRY C ASN G D+
Sbjct: 1145 GNPEPQLSWSKDGVVLQGRGP-----QGSVHFAAIRTS---DAGRYRCEASNSAGVDAWE 1196
Query: 354 AEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAV----PQAQHLVAQPR 409
E+ + + D + R+ N P P P ++ L QP
Sbjct: 1197 VELRV--LEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPG 1254
Query: 410 VATIQQ-----------------CQSPTNYLQGLDGKPIIAAPVFTKMLQ-----NLSAS 447
VA +++ CQ+ TN + + + V + + N+S
Sbjct: 1255 VAVLEEGSLFLASVSPADSGDYECQA-TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGM 1313
Query: 448 EGQLVVFECRVKGAPSPKVEWYREGTLIE-----DSPDFRILQKKPRSMAEPEEICTLVI 502
GQ + EC G P P++ W ++ L+ + + + +E +L
Sbjct: 1314 AGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHF 1373
Query: 503 AEVFAEDSGCFTCTASNKYGT 523
+ DSG ++C A N+ GT
Sbjct: 1374 PRIQEGDSGLYSCRAENQAGT 1394
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/298 (22%), Positives = 107/298 (35%), Gaps = 53/298 (17%)
Query: 276 RSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEED 335
R V EG V+LDC G PPP V W +G L H+ + SL + D
Sbjct: 3225 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 3284
Query: 336 TGRYSCFASNIYGTDST--SAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEV--------S 385
G Y+C A N G D+ + + + ++G + +P E+
Sbjct: 3285 AGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG-----TLVSRPGELVTMVCPVRG 3339
Query: 386 SPPTTSAVIPPAVP----QAQHLVAQPRVATIQQCQ------------SPT-----NYLQ 424
SPP + + +P Q L I + Q SP N+
Sbjct: 3340 SPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTL 3399
Query: 425 GLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRIL 484
+ P++ F ++ G LV C +G P P V W ++G
Sbjct: 3400 QVQVPPVLEPVEFQ---NDVVVVRGSLVELPCEARGVPLPLVSWMKDG------------ 3444
Query: 485 QKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNG 542
+P E+ +L + V A DSG ++C A ++ G QL V + ++G
Sbjct: 3445 --EPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG 3500
Score = 60.5 bits (145), Expect = 1e-08
Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 37/286 (12%)
Query: 269 PRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTI 328
P FT R + G R+ L C G P P++ W + + + + +L
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG----VSEQDGGSTLQR 4184
Query: 329 AEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEM--NRIQKPNEVSS 386
A ED+G Y C+A N G + ++++ E E IQ V
Sbjct: 4185 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRG 4244
Query: 387 PPTTSAV-IPPAVP-QAQHLVAQPRVATIQ------------QCQSPTNYLQGLDGKPII 432
P I +P + HL Q + ++ QC + G+ K +I
Sbjct: 4245 DPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENE--MGVAKKVVI 4302
Query: 433 ----AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+APVF Q+++ G V C+ G P+P +EW + G + S R L
Sbjct: 4303 LVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG- 4361
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+L + V D+G + C A N G+ ++ A L VRG
Sbjct: 4362 ----------SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397
Score = 60.1 bits (144), Expect = 1e-08
Identities = 68/295 (23%), Positives = 115/295 (38%), Gaps = 45/295 (15%)
Query: 268 PPRFTQKLRSRE----VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNL 323
PP F Q R + V G + L C +P P V WY +G+ L + ++ G
Sbjct: 3028 PPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGG-- 3085
Query: 324 HSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNE 383
L I EA D G YSC SN+ G + + V + +P E ++++
Sbjct: 3086 QRLEIQEAQVSDKGLYSCKVSNVAG---EAVRTFTLTVQVPPTFENPKTETVSQVAGSPL 3142
Query: 384 VSSPPTTSAVIP---------PAVPQAQHLV----AQPRVATIQQCQSPT-----NYLQG 425
V + + P P A H V + +++ +Q Q+ T Q
Sbjct: 3143 VLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQA 3202
Query: 426 LDGKPIIAAPVFTKMLQNLSAS------EGQLVVFECRVKGAPSPKVEWYREGTLI--ED 477
K + A + +++ + EGQ V +C G P P V W ++G+ + +
Sbjct: 3203 EARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDM 3262
Query: 478 SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
P R + +LV+ + A D+G +TC A N G + + ++V
Sbjct: 3263 GPHLRFYL----------DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 3307
Score = 58.2 bits (139), Expect = 5e-08
Identities = 63/277 (22%), Positives = 107/277 (38%), Gaps = 62/277 (22%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKE-LENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
G V+L C G+P PQV W + + L P + + + G + L I + D GRY C
Sbjct: 1423 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV--LRITGSHVGDEGRYQC 1480
Query: 342 FASNIYGTDSTSAEIYIEG---VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTS------- 391
A + G + ++ + + S+ G+ E + +Q E PT +
Sbjct: 1481 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 1540
Query: 392 AVIPPAVP--------QAQHLVAQPRVATIQQCQS------------------PTNYLQG 425
A++P + Q Q AQ A + C++ PT ++G
Sbjct: 1541 ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT--IEG 1598
Query: 426 LDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQ 485
G+P + + A G+ V EC +G PSP + W+ EG + +S + R+
Sbjct: 1599 AGGRPYV-----------VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL-- 1645
Query: 486 KKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ L + SG ++C AS+ G
Sbjct: 1646 --------ETDGSVLRLESPGEASSGLYSCVASSPAG 1674
Score = 56.6 bits (135), Expect = 2e-07
Identities = 55/276 (19%), Positives = 99/276 (35%), Gaps = 33/276 (11%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP ++ V E V L+C+ G+PPP V W+ + + + + + G + L
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV--LR 1942
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIE---------GVSSSDSEGDPNKEEMNRI 378
I +A D G Y C ASN+ G+ + + + P + N
Sbjct: 1943 IEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNAT 2002
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTN--------YLQGLDGKP 430
P+ + PA + RV T+ ++ + G D +
Sbjct: 2003 GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQD 2062
Query: 431 II----AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 486
++ P N+S + V EC+ P P + W+++G +E P +
Sbjct: 2063 VVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSAD 2122
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
K + ++ D+G +TC A N+ G
Sbjct: 2123 KALLQVDRADVW----------DAGHYTCEALNQAG 2148
Score = 56.6 bits (135), Expect = 2e-07
Identities = 59/264 (22%), Positives = 98/264 (37%), Gaps = 30/264 (11%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C V P P++ W+ +G L+ + G L + D+G YSC A N
Sbjct: 3601 LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF--LQLQALSTADSGDYSCTARNAA 3658
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK--------PNEVSSPPTTSAVIPPAVP 399
G+ S + + I V + S +N+ P + S + P P
Sbjct: 3659 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP 3718
Query: 400 QAQHLVAQPRVATIQQCQSPTNYL-----------QGLDGKPIIAAPVFTKMLQNLSASE 448
+ + L Q +YL QG D + ++ P NL+ +
Sbjct: 3719 RFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR-VLEPPAIAPSPSNLTLTA 3777
Query: 449 GQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAE 508
+ C G+P P V W+++G + DFR+ Q R + L++ +
Sbjct: 3778 HTPALLPCEASGSPKPLVVWWKDGQKL----DFRLQQGAYRLLPSN----ALLLTAPGPQ 3829
Query: 509 DSGCFTCTASNKYGTVSSIAQLHV 532
DS F C SN+ G + Q+ V
Sbjct: 3830 DSAQFECVVSNEVGEAHRLYQVTV 3853
Score = 55.8 bits (133), Expect = 3e-07
Identities = 59/274 (21%), Positives = 103/274 (37%), Gaps = 42/274 (15%)
Query: 279 EVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGR 338
+V +G L C V G P P++ W+ +G+ L HI G L L + +A G
Sbjct: 2456 KVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVL--LQVLQANLSSAGH 2513
Query: 339 YSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVS---------SPPT 389
YSC A+N G + ++ + + + + +E + N +S SP
Sbjct: 2514 YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI 2573
Query: 390 T------------SAVIPPAVPQAQHLVAQPR-------VATIQQCQSPTNYLQGLDGKP 430
T + + P Q L AQ V T + ++ NY + P
Sbjct: 2574 TWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 2633
Query: 431 IIAA--PVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
I+ P+ ++ + + EC P P + WY++G + S ++L +
Sbjct: 2634 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 2693
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+P ++ DSG + C A+N G
Sbjct: 2694 LLQIQPTQV----------SDSGRYLCVATNVAG 2717
Score = 54.3 bits (129), Expect = 8e-07
Identities = 62/284 (21%), Positives = 102/284 (35%), Gaps = 61/284 (21%)
Query: 286 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASN 345
+ L C + P P + W +G E S +I ++ H L I A +ED G+Y+C +N
Sbjct: 2559 ISLICEALAFPSPNITWMKDGAPFEASRNIQLLPG--THGLQILNAQKEDAGQYTCVVTN 2616
Query: 346 IYGTDSTSAEIYI---EGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIP------- 395
G + + + +S D G+ +E+ K N + S +P
Sbjct: 2617 ELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK--TKVNSTLTLECESWAVPPPTIRWY 2674
Query: 396 ----PAVPQAQ-HLVAQPRVATIQ--QCQSPTNYL---------QGLDGKPIIAAPVFTK 439
P P ++ ++ + R+ IQ Q YL D +I P +
Sbjct: 2675 KDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQ 2734
Query: 440 MLQNLSAS---------------------EGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
+ + SA+ E C P P + WYRE +
Sbjct: 2735 KVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAG 2794
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
+ +LQ L I V AE++G ++C ASN+ G
Sbjct: 2795 DEVSVLQGGR----------VLQIPLVRAENAGRYSCKASNEVG 2828
Score = 53.9 bits (128), Expect = 1e-06
Identities = 69/281 (24%), Positives = 104/281 (37%), Gaps = 54/281 (19%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V G L C V+G P + W + + L S + Q +L SL I+ D GRY
Sbjct: 528 VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-RVAQLADL-SLEISGIIPTDGGRY 585
Query: 340 SCFASNIYGTD----------------STSAEIYIEGVS---SSDSEGDPN-----KEEM 375
C ASN G TS++ + +GV S + G P E
Sbjct: 586 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 645
Query: 376 NRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA-- 433
+Q+ + + + +I P+ A CQ+ TN + G D + +
Sbjct: 646 QALQEDSRIHVDAQGTLIIQGVAPED---------AGNYSCQA-TNEV-GTDQETVTLYY 694
Query: 434 --APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
P + + + + G+ V C G P P+V WYR G + +P
Sbjct: 695 TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------ 742
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
E L I D+G +TC A N+ G S+ QL V
Sbjct: 743 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 782
Score = 53.9 bits (128), Expect = 1e-06
Identities = 66/272 (24%), Positives = 96/272 (35%), Gaps = 60/272 (22%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVV-GIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
PP+ + V EG V L CIV+ G P P+ W +G+ L I G+LH
Sbjct: 884 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH-- 941
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
+ A +E GRYSC A+N G+ E+ +Q P +
Sbjct: 942 -LDRALQEHAGRYSCVATNTAGSQHRDVELV--------------------VQVPPRIHP 980
Query: 387 PPT---TSAVIPPAVPQAQHLVAQPRVATIQQCQSPT----NYLQGLDGKPIIAAP---- 435
T T+ +P ++P V P + ++ + T +Y +G +IA P
Sbjct: 981 TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQD 1040
Query: 436 --VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAE 493
+ N Q V K W G L S
Sbjct: 1041 AGAYVCTATNTVGFSSQ--EMRLSVNRLALSKYVWEEYGLLPSGS--------------- 1083
Query: 494 PEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
L +A+V DSG + CTASN G+ S
Sbjct: 1084 ------LRLAQVQVGDSGHYECTASNPAGSAS 1109
Score = 53.5 bits (127), Expect = 1e-06
Identities = 57/268 (21%), Positives = 100/268 (37%), Gaps = 35/268 (13%)
Query: 288 LDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIY 347
L+C G PPP V W +G+ + + + G SL + A TGRYSC A N+
Sbjct: 2278 LECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ--SLHVERAQAAHTGRYSCVAENLA 2335
Query: 348 GTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKP-----NEVSSPPTT----SAVIPPAV 398
G E+ + + DP + P + PP P +
Sbjct: 2336 GRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 2395
Query: 399 PQAQHLVAQPRVATIQQCQSPTNYL-------------QGLDGKPIIAAPVFTKMLQN-L 444
+ +L+A + + Q Q + L + + ++ + + L+ +
Sbjct: 2396 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVI 2455
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
+GQ C V G P PK+ W+++G R L + P+ + L + +
Sbjct: 2456 KVLDGQTAHLMCNVTGHPQPKLTWFKDG---------RPLARGDAHHISPDGV-LLQVLQ 2505
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHV 532
+G ++C A+N G + QL V
Sbjct: 2506 ANLSSAGHYSCIAANAVGEKTKHFQLSV 2533
Score = 52.4 bits (124), Expect = 3e-06
Identities = 69/305 (22%), Positives = 111/305 (36%), Gaps = 60/305 (19%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYC-EGKEL-----------ENS 312
+G P+ T+ R V G L C G PPP V W +G+ L
Sbjct: 782 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 841
Query: 313 PDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK 372
PD +G L ++A ED Y C A N++G A + + G + +
Sbjct: 842 PD-----SGVLFFESVAP---EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA---SS 890
Query: 373 EEMNRIQKPNEVSSPPTTSAVIP-----------PAVPQAQHLVA-----------QPRV 410
R+ + VS P A P P P ++H + Q
Sbjct: 891 APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHA 950
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAP--VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ T Q D + ++ P + +++ +EG C G P+P + W
Sbjct: 951 GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHIT-NEGVPASLPCVASGVPAPTITW 1009
Query: 469 YRE-GTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSI 527
+E L P + + ++ TL+IA+ A+D+G + CTA+N G S
Sbjct: 1010 TKETNALTSRGPHYNVSKEG-----------TLLIAQPSAQDAGAYVCTATNTVGFSSQE 1058
Query: 528 AQLHV 532
+L V
Sbjct: 1059 MRLSV 1063
Score = 50.4 bits (119), Expect = 1e-05
Identities = 60/271 (22%), Positives = 106/271 (39%), Gaps = 45/271 (16%)
Query: 290 CIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGT 349
C +GIPPP +RW+ + + D +++ G + L + + E+D+G YSC ASN G
Sbjct: 2374 CEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM--LKMTQTQEQDSGLYSCLASNEAGE 2431
Query: 350 DSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPN------EVSSPPTTSAV-----IPPAV 398
+ + + S ++E + EE+ ++ V+ P P A
Sbjct: 2432 ARRNFSVEVLVPPSIENE---DLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLAR 2488
Query: 399 PQAQHL--------VAQPRVATIQQCQSPTNYLQGLDGK----PIIAAPVFTKMLQNLSA 446
A H+ V Q +++ G K ++ AP ++ +
Sbjct: 2489 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 2548
Query: 447 SEGQLVV-----FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
E + V C PSP + W ++G E S + ++L P + L
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLL---PGTHG-------LQ 2598
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
I ED+G +TC +N+ G ++ HV
Sbjct: 2599 ILNAQKEDAGQYTCVVTNELG--EAVKNYHV 2627
Score = 50.4 bits (119), Expect = 1e-05
Identities = 72/319 (22%), Positives = 107/319 (33%), Gaps = 56/319 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
+T +P C+ G P P V W+KDG+++ R + R +L + + D
Sbjct: 3775 LTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSN--ALLLTAPGPQDSA 3832
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+ + +N G++HR Q P P
Sbjct: 3833 QFECVVSN-----------------------EVGEAHR---LYQVTVHVP-------PTI 3859
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
D L C +G+P P ++W G + S R + +L I
Sbjct: 3860 ADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSG---YRVSPSGALEIGQ 3916
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEV-KKAPVILEKLQNCGVPEGHPVRLECR 1194
AG Y C A N G + L+V A V K P ++ + V L C
Sbjct: 3917 ALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE------EEVLLPCE 3970
Query: 1195 VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGI 1254
G+P P W+K+ + + L I A DAG Y AKN AG
Sbjct: 3971 ASGIPRPTITWQKEGLNVAT-----GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Query: 1255 VSCTARLDIYAQWHHQIPP 1273
RL + Q+PP
Sbjct: 4026 AMGKTRLVV------QVPP 4038
Score = 48.5 bits (114), Expect = 4e-05
Identities = 60/274 (21%), Positives = 101/274 (36%), Gaps = 48/274 (17%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKEL--ENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
V EG L C G+P P++ W +G+ L E + H+ G L L A+ +E G
Sbjct: 2174 VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--G 2231
Query: 338 RYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKE-----------EMNRIQKPNEVSS 386
Y+C SN+ G S ++ + +P + E N KP
Sbjct: 2232 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP----- 2286
Query: 387 PPTTS---AVIPPAVPQAQHLVAQPRVATIQQCQSP-----TNYLQGLDGK-------PI 431
PPT + P L Q + +++ Q+ + + L G+ +
Sbjct: 2287 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV 2346
Query: 432 IAAPVF---TKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKP 488
+ P L N++A+ + C G P P + W+R + D +L
Sbjct: 2347 LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGG- 2405
Query: 489 RSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYG 522
L + + +DSG ++C ASN+ G
Sbjct: 2406 ---------WMLKMTQTQEQDSGLYSCLASNEAG 2430
Score = 48.1 bits (113), Expect = 5e-05
Identities = 48/203 (23%), Positives = 81/203 (39%), Gaps = 23/203 (11%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
+ C V P L L G+ L + H +E+G S I ++ + GTY+C A ++
Sbjct: 446 VSCSVHSALPFRLQ-LRRGEARLGEERH---FQESGNSSWEILRASKAEEGTYECTAVSR 501
Query: 1152 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNET 1211
G ++ V + P N V G L CRV+G P W +D
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPA-----PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 556
Query: 1212 IPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQI 1271
+P + R++ D + L I +D G Y A N G+ + L + +
Sbjct: 557 LPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANGVTRASVWLLV------RE 606
Query: 1272 PPPMSVRPSGSRYGSLTSKGLDI 1294
P +S+ S + S+G+++
Sbjct: 607 APQVSIHTSSQHF----SQGVEV 625
Score = 45.4 bits (106), Expect = 4e-04
Identities = 67/307 (21%), Positives = 109/307 (35%), Gaps = 56/307 (18%)
Query: 268 PPRFTQKLRSREVP--EGTRVQLDCIVVGIPPPQVRWYCEGKELENSP--------DIHI 317
PP + R V G + L+C G P P++ W + +L P D+
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA-QLVGVPLGWAGYGWDLGW 1356
Query: 318 VQAGNLHSLTIAEAF------EEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPN 371
Q G L ++ E D+G YSC A N GT + + ++ G
Sbjct: 1357 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV--LTPPSVLGAGA 1414
Query: 372 KEEMNRIQKPNEVSSPPTTSAVIP---------PAVPQAQHLVAQPRVATIQ-------- 414
+E+ + + T+ P P +P HL Q ++
Sbjct: 1415 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 1474
Query: 415 ----QCQ--SPTNYLQGLDGKPIIAAPVF---TKMLQNLSASEGQLVVFECRVKGAPSPK 465
QC SP Q D + + AP + ++ E LV C +G P+P
Sbjct: 1475 EGRYQCVAFSPAGQ-QARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN 1533
Query: 466 VEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVS 525
+ W+++G L+ S + + R L + + D+G +TC ASN G
Sbjct: 1534 ITWFKDGALLPTSTKV-VYTRGGRQ---------LQLGRAQSSDAGVYTCKASNAVGAAE 1583
Query: 526 SIAQLHV 532
+L V
Sbjct: 1584 KATRLDV 1590
Score = 45.1 bits (105), Expect = 5e-04
Identities = 75/351 (21%), Positives = 116/351 (33%), Gaps = 75/351 (21%)
Query: 223 EVNHALEQQEAKRREAEQAASEAAGGDTTPGSSPSS---LYYEEPLGQPPRF--TQKLRS 277
E N + + + E ++G + SSP+ L Y + PP+ + L
Sbjct: 1639 ESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQ 1698
Query: 278 REVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTG 337
G ++L C G P P ++W G+ E + + G +L I + +G
Sbjct: 1699 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGT--TLHIDHVELDHSG 1756
Query: 338 RYSCFASNIYGTDSTSAEIYIEGV--------------------SSSDSEGDPNKEE--- 374
++C A+N GT E+ + G SS + DP
Sbjct: 1757 LFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 1816
Query: 375 -------MNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNY----- 422
+ P + PT V P Q R I C + TN
Sbjct: 1817 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTC-AATNLAGESK 1875
Query: 423 ----LQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIED- 477
L+ L I PV +L+N S V EC G P P V W++ +
Sbjct: 1876 REVALKVLVPPNIEPGPVNKAVLENAS------VTLECLASGVPPPDVSWFKGHQPVSSW 1929
Query: 478 -----SPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGT 523
S D R+L+ I + D+G + C ASN G+
Sbjct: 1930 MGVTVSVDGRVLR----------------IEQAQLSDAGSYRCVASNVAGS 1964
Score = 44.7 bits (104), Expect = 6e-04
Identities = 55/290 (18%), Positives = 101/290 (34%), Gaps = 50/290 (17%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
PP L EG+ L C G P P + W +G+ + + +Q L
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG--ELL 4094
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVS-SSDSEGDPNKEEMNRIQKPNEVSS 386
+ +D G Y+C A N G + I + + GD + +R+
Sbjct: 4095 VKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARG 4154
Query: 387 PPTTSAVIPPAV-------PQAQHLVAQPRVATIQQC----QSPTNYLQGLDGK------ 429
PT P + P + + Q +T+Q+ + Y+ + +
Sbjct: 4155 SPT------PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQA 4208
Query: 430 ---------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD 480
P++ F+ +++ + S + +C V+G P P + W ++G + S
Sbjct: 4209 VSFVHVKEAPVLQGEAFSYLVEPVGGS----IQLDCVVRGDPVPDIHWIKDGLPLRGSHL 4264
Query: 481 FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
LQ +L I +D+G + C A N+ G + L
Sbjct: 4265 RHQLQNG-----------SLTIHRTERDDAGRYQCLAENEMGVAKKVVIL 4303
Score = 44.3 bits (103), Expect = 8e-04
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 944 APIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCS 1003
AP+F + V G V C+ G P P + W + G+ + ++R DG S
Sbjct: 4308 APVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASR---RLRTLPDG--S 4362
Query: 1004 LHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
L +E+ + D G Y +A N G + L+V+ P
Sbjct: 4363 LWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 42.4 bits (98), Expect = 0.003
Identities = 75/341 (21%), Positives = 113/341 (33%), Gaps = 96/341 (28%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELEN-SPDIHIVQAGNL--- 323
PPR EG L C+ G+P P + W E L + P ++ + G L
Sbjct: 975 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 1034
Query: 324 -----------------------------------------------HSLTIAEAFEEDT 336
SL +A+ D+
Sbjct: 1035 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDS 1094
Query: 337 GRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK---------------- 380
G Y C ASN G+ S Y+ GV + P + R+ K
Sbjct: 1095 GHYECTASNPAGSASHR---YVLGV-----QVPPQVQPGPRVLKVLVGEALDLNCVAEGN 1146
Query: 381 PNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDG---------KPI 431
P S V+ PQ A R + + + + G+D P
Sbjct: 1147 PEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPH 1206
Query: 432 IAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
A + +L+ ++ L C +G P P+V W R+G P L +P +
Sbjct: 1207 WGADETSGLLERVAGENASL---PCPARGTPKPQVTW-RKG------PSSEPLHGQP-GV 1255
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
A EE +L +A V DSG + C A+N+ G+ S A+L V
Sbjct: 1256 AVLEE-GSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 42.0 bits (97), Expect = 0.004
Identities = 27/96 (28%), Positives = 39/96 (40%), Gaps = 3/96 (3%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLH 324
L P F + + V G V L C G P P + W G+ L S + + G
Sbjct: 4305 LQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG--- 4361
Query: 325 SLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG 360
SL + D G Y C A N+ G+ + A + + G
Sbjct: 4362 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRG 4397
Score = 40.8 bits (94), Expect = 0.009
Identities = 70/319 (21%), Positives = 106/319 (33%), Gaps = 44/319 (13%)
Query: 240 QAASEAAGGDTT----PGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGI 295
QA S A GD + + +S+ + + P + V L C G+
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 3699
Query: 296 PPPQVRWYCEGKELE-NSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSA 354
P P V W + L+ SP I+ G SL I +D G Y C ASN G+D
Sbjct: 3700 PAPLVSWRKDRVPLDPRSPRFEILPEG---SLRIQPVLAQDAGHYLCLASNSAGSDRQGR 3756
Query: 355 EI-YIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQ------ 407
++ +E + + S + P E S P V + + Q
Sbjct: 3757 DLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL 3816
Query: 408 PRVATIQQCQSPTNYLQ-------------GLDGKPIIAAPVFTKMLQNLSASEGQLVVF 454
P A + P + Q L + P + + + VV
Sbjct: 3817 PSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVL 3876
Query: 455 ECRVKGAPSPKVEWYREGT-LIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCF 513
C G P+P V W + G L +R+ P E I + +G +
Sbjct: 3877 TCHSTGIPAPTVSWSKAGAQLGARGSGYRV---SPSGALE--------IGQALPIHAGRY 3925
Query: 514 TCTASNKYGTVSSIAQLHV 532
TC+A N G +A HV
Sbjct: 3926 TCSARNSAG----VAHKHV 3940
Score = 40.4 bits (93), Expect = 0.011
Identities = 62/311 (19%), Positives = 103/311 (33%), Gaps = 48/311 (15%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+PP + + T L C G P P V W+ +G++L+ + ++L
Sbjct: 3762 EPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNAL 3821
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSS 386
+ +D+ ++ C SN G + +Y V + D + + P ++
Sbjct: 3822 LLTAPGPQDSAQFECVVSNEVGE---AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTC 3878
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA------------- 433
T IP AQ SP+ L+ PI A
Sbjct: 3879 HSTG---IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 3935
Query: 434 -----------APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFR 482
+PV + + A + V+ C G P P + W +EG + +
Sbjct: 3936 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ 3995
Query: 483 ILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR-------GN 535
+L L IA ED+G + C A N G+ +L V+ G
Sbjct: 3996 VLPGG-----------QLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL 4044
Query: 536 EDLSNNGSLHS 546
DLS H+
Sbjct: 4045 PDLSTTEGSHA 4055
Score = 39.7 bits (91), Expect = 0.019
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 10/91 (10%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
N++ S G+ V CRV G + W R D+R+L +A+ ++ +L I
Sbjct: 525 NVTVSPGETAVLSCRVLGEAPYNLTWVR---------DWRVLPASTGRVAQLADL-SLEI 574
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ + D G + C ASN G + L VR
Sbjct: 575 SGIIPTDGGRYQCVASNANGVTRASVWLLVR 605
Score = 34.3 bits (77), Expect = 0.81
Identities = 50/269 (18%), Positives = 98/269 (36%), Gaps = 37/269 (13%)
Query: 283 GTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCF 342
G V + C V G PP V W +G L S + G+ H+L I++ D G ++C
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQ--RTLLHGSGHTLRISKVQLADAGIFTCV 3385
Query: 343 ASNIYGTDSTSAEIYIEG---VSSSDSEGDPNKEEMNRIQKPNEVSSPPTT--------S 391
A++ G + + ++ + + + D + ++ P E P
Sbjct: 3386 AASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGE 3445
Query: 392 AVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGK-----PIIAAPVFTKMLQ--NL 444
++ ++ Q L + A S + + + ++ P Q L
Sbjct: 3446 PLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTEL 3505
Query: 445 SASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAE 504
S + G + C +G P P + W+++G + + E T V+
Sbjct: 3506 SLTPGAPMELLCDAQGTPQPNITWHKDGQAL--------------TRLENNSRATRVLR- 3550
Query: 505 VFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
D+G +TC A + G + ++ V+
Sbjct: 3551 --VRDAGLYTCLAESPAGAIEKSFRVRVQ 3577
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 105 bits (263), Expect = 2e-22
Identities = 85/309 (27%), Positives = 127/309 (41%), Gaps = 56/309 (18%)
Query: 955 RVTEGSPVTFTCKIV-GIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDD 1013
RV EG PV+ C ++ G P+P+ +W KDG+ + + H +R +G SLH++ +
Sbjct: 778 RVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRH-SIRADG----SLHLDRALQEH 832
Query: 1014 DGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
G Y+ +A N G L+VQ P R+ H
Sbjct: 833 AGRYSCVATNTAGSQHRDVELVVQVPP---RIHPTATHH--------------------- 868
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
+ +EG L C SG+P P +TW + H + +E +LLI
Sbjct: 869 ---------ITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG---TLLI 916
Query: 1134 DPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP------EGH 1187
+ +DAG Y C ATN G +S + LSV K + + +N VP G
Sbjct: 917 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP----RIHMNGSRNANVPLQVTAKAGE 972
Query: 1188 PVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLS 1247
V L+C G PPP+ W KD+ +P R + L + + D+G Y +
Sbjct: 973 EVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS----GSLRLAQVQVGDSGHYECT 1028
Query: 1248 AKNEAGIVS 1256
A N AG S
Sbjct: 1029 ASNPAGSAS 1037
Score = 88.6 bits (218), Expect = 4e-17
Identities = 89/344 (25%), Positives = 127/344 (36%), Gaps = 53/344 (15%)
Query: 925 VDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFK-DGK 983
V+E D ++ G AP + + V G C+ G P P V W + DG+
Sbjct: 651 VNELGDASAEIQLAVGH--APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
Query: 984 QISKR---NEHCKMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLP 1040
+ R + R+ G L ES +D Y A N G++ L+V
Sbjct: 709 PLGLRLGAGRGSRSRQPDSGV--LFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG-- 764
Query: 1041 IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKV-SGL 1099
P + + EG+ L C V +G
Sbjct: 765 -----------------------------HAPPQIASSAPTVRVLEGQPVSLPCIVLAGR 795
Query: 1100 PPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSL 1159
P PE WL +G+P+ P + H +R G SL +D Q AG Y C+ATN G +
Sbjct: 796 PLPERHWLKDGRPLPPGSRHS--IRADG--SLHLDRALQEHAGRYSCVATNTAGSQHRDV 851
Query: 1160 ELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERI 1219
EL VV + P + N EG P L C G+P P W K+ +
Sbjct: 852 EL-VVQVPPRIHPTATHHITN----EGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 906
Query: 1220 SMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDI 1263
++ ++ T LLI DAG Y +A N G S RL +
Sbjct: 907 NVSKEGT----LLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 946
Score = 83.2 bits (204), Expect = 2e-15
Identities = 87/341 (25%), Positives = 125/341 (36%), Gaps = 62/341 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G C+ G+P P+V W++ G ++ + EG + L I + D G
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMI-------LAPEGSSSGKLRIPAAQERDAG 644
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
YT A N G S L V P + L
Sbjct: 645 TYTCRAVNELGDASAEIQLAVGHAPQLTEL------------------------------ 674
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLL-NGQP--VLPDASHKMLVRETGVHSLL 1132
P D+ GR L C+ +G PPP +TW +GQP + A R+ L
Sbjct: 675 ---PRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLF 731
Query: 1133 IDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLE 1192
+ + D Y C A N G+ L V P I V EG PV L
Sbjct: 732 FESVAPEDQAPYVCEARNVFGKVQAEARLIVTG---HAPPQIASSAPTVRVLEGQPVSLP 788
Query: 1193 CRVI-GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNE 1251
C V+ G P P +W KD +P R S+ D L + A + AG Y+ A N
Sbjct: 789 CIVLAGRPLPERHWLKDGRPLP-PGSRHSIRAD----GSLHLDRALQEHAGRYSCVATNT 843
Query: 1252 AGIVSCTARLDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGL 1292
AG L + Q+PP + P+ + + +T++G+
Sbjct: 844 AGSQHRDVELVV------QVPP--RIHPTATHH--ITNEGV 874
Score = 81.3 bits (199), Expect = 6e-15
Identities = 79/318 (24%), Positives = 121/318 (38%), Gaps = 65/318 (20%)
Query: 952 KHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTS 1011
+HF ++G V +C G P P + W ++ + + E ++ + GT L I+
Sbjct: 500 QHF--SQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIHVDAQGT--LIIQGVAP 552
Query: 1012 DDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFF 1071
+D GNY+ A N G D+E + +
Sbjct: 553 EDAGNYSCQATNEVGT----------------------------------DQETVTLYYT 578
Query: 1072 RPHFLQAPGDMV-AHEGRLCRLDCKVSGLPPPELTWLLNGQPVL--PDASHKMLVRETGV 1128
P + A +V G L C+ SG+PPP + W G ++ P+ S +R
Sbjct: 579 DPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLR---- 634
Query: 1129 HSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHP 1188
I +RDAGTY C A N+ G S ++L+ V AP + E ++ V G
Sbjct: 635 ----IPAAQERDAGTYTCRAVNELGDASAEIQLA-----VGHAPQLTELPRDVTVELGRS 685
Query: 1189 VRLECRVIGMPPPVFYWKKDNE-----TIPCTRERISMHQDTTGYACLLIQPAKKSDAGW 1243
L CR G PPP W++ + + R S D+ L + D
Sbjct: 686 ALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDS---GVLFFESVAPEDQAP 742
Query: 1244 YTLSAKNEAGIVSCTARL 1261
Y A+N G V ARL
Sbjct: 743 YVCEARNVFGKVQAEARL 760
Score = 77.0 bits (188), Expect = 1e-13
Identities = 62/231 (26%), Positives = 90/231 (38%), Gaps = 33/231 (14%)
Query: 933 QHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHC 992
QH ++ + P H EG P + C G+P P + W K+ ++ R H
Sbjct: 847 QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 906
Query: 993 KMRREGDGTCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSH 1052
+ +EG +L I ++ D G Y A N G S L V + P + H
Sbjct: 907 NVSKEG----TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP---------RIH 953
Query: 1053 RGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQP 1112
SR PLQ + A G LDC+ G PPP +TW + +P
Sbjct: 954 MNGSR---NANVPLQ--------------VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRP 996
Query: 1113 VLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
V P + L+ SL + + D+G Y+C A+N G S L V
Sbjct: 997 VPPITNRYGLLPS---GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGV 1044
Score = 75.5 bits (184), Expect = 3e-13
Identities = 75/310 (24%), Positives = 120/310 (38%), Gaps = 30/310 (9%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
+ P+ + S+ +G V++ C G P P + W E + L+ IH+ G +L
Sbjct: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TL 545
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDS----------EGDPNKEEMN 376
I ED G YSC A+N GTD + +Y S + E E +
Sbjct: 546 IIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS 605
Query: 377 RIQKPNEVSSPPTTSAVIPPAVPQAQHL---VAQPRVATIQQCQSPTNYLQGLDGKPIIA 433
+ P + ++ P + L AQ R A C++ N L + +A
Sbjct: 606 GVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELGDASAEIQLA 664
Query: 434 ---APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS 490
AP T++ ++++ G+ + CR G P P V W R + P L S
Sbjct: 665 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRG----DGQPLGLRLGAGRGS 720
Query: 491 MAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSANST 550
+ + L V ED + C A N +G V + A+L V G + A+S
Sbjct: 721 RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG------HAPPQIASSA 774
Query: 551 TNLAAIEPQP 560
+ +E QP
Sbjct: 775 PTVRVLEGQP 784
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/231 (26%), Positives = 104/231 (45%), Gaps = 26/231 (11%)
Query: 1046 TSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELT 1105
T+ ++ GR++ Q +P + P+ +PG+ L C+V G P LT
Sbjct: 380 TAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAV-------LSCRVLGEAPYNLT 432
Query: 1106 WLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVA 1165
W+ + + VLP ++ + V + SL I + D G Y+C+A+N G S+ L V
Sbjct: 433 WVRDWR-VLPASTGR--VAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV-- 487
Query: 1166 KEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDT 1225
++AP + + +G V++ C G P P W ++++ + +E +H D
Sbjct: 488 ---REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL---QEDSRIHVDA 541
Query: 1226 TGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMS 1276
G L+IQ DAG Y+ A NE G T L ++ PP +S
Sbjct: 542 QG--TLIIQGVAPEDAGNYSCQATNEVGTDQETVTL------YYTDPPSVS 584
Score = 71.2 bits (173), Expect = 6e-12
Identities = 75/310 (24%), Positives = 113/310 (36%), Gaps = 57/310 (18%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V+ G +C+++G + W +D + + + SL I D G
Sbjct: 411 VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD----LSLEISGIIPTDGG 466
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
Y +A+N G S L+V+ P S TS+ HF
Sbjct: 467 RYQCVASNANGVTRASVWLLVREAPQVSIHTSS------------------------QHF 502
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDP 1135
Q G ++ C SG P P ++W Q + D+ + + T L+I
Sbjct: 503 SQ---------GVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGT----LIIQG 549
Query: 1136 LTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKA--PVILEKLQNCGVPEGHPVRLEC 1193
+ DAG Y C ATN+ G + ++ L A V+L V G L C
Sbjct: 550 VAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL-------VAVGEEAVLVC 602
Query: 1194 RVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAG 1253
G+PPP W + + E S + L I A++ DAG YT A NE G
Sbjct: 603 EASGVPPPRVIWYRGGLEMILAPEGSSSGK-------LRIPAAQERDAGTYTCRAVNELG 655
Query: 1254 IVSCTARLDI 1263
S +L +
Sbjct: 656 DASAEIQLAV 665
Score = 67.4 bits (163), Expect = 9e-11
Identities = 80/297 (26%), Positives = 120/297 (40%), Gaps = 47/297 (15%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVV-GIPPPQVRWYCEGKELENSPDIHIVQAGNLHSL 326
PP+ + V EG V L CIV+ G P P+ W +G+ L I G+LH
Sbjct: 767 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH-- 824
Query: 327 TIAEAFEEDTGRYSCFASNIYGTDSTSAEIYI----------------EGVSSS---DSE 367
+ A +E GRYSC A+N G+ E+ + EGV +S +
Sbjct: 825 -LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVAS 883
Query: 368 GDPN-----KEEMNRI--QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT 420
G P +E N + + P+ S T + A P AQ A AT S
Sbjct: 884 GVPAPTITWTKETNALTSRGPHYNVSKEGTLLI---AQPSAQDAGAYVCTATNTVGFSSQ 940
Query: 421 NYLQGLDGKPII--AAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
++ KP I + ++A G+ V +C KG+P P V W ++ +
Sbjct: 941 EMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI 1000
Query: 479 PD-FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRG 534
+ + +L +L +A+V DSG + CTASN G+ S L V+G
Sbjct: 1001 TNRYGLLPSG-----------SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQG 1046
Score = 58.9 bits (141), Expect = 3e-08
Identities = 96/430 (22%), Positives = 155/430 (36%), Gaps = 82/430 (19%)
Query: 265 LGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYC-EGKEL-----------ENS 312
+G P+ T+ R V G L C G PPP V W +G+ L
Sbjct: 665 VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ 724
Query: 313 PDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNK 372
PD +G L ++A ED Y C A N++G A + + G + +
Sbjct: 725 PD-----SGVLFFESVAP---EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA---SS 773
Query: 373 EEMNRIQKPNEVSSPPTTSAVIP-----------PAVPQAQHLVA-----------QPRV 410
R+ + VS P A P P P ++H + Q
Sbjct: 774 APTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHA 833
Query: 411 ATIQQCQSPTNYLQGLDGKPIIAAP--VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEW 468
+ T Q D + ++ P + +++ +EG C G P+P + W
Sbjct: 834 GRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHIT-NEGVPASLPCVASGVPAPTITW 892
Query: 469 YRE-GTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSI 527
+E L P + + ++ TL+IA+ A+D+G + CTA+N G S
Sbjct: 893 TKETNALTSRGPHYNVSKEG-----------TLLIAQPSAQDAGAYVCTATNTVGFSSQE 941
Query: 528 AQLHVRGNEDLSNNGSLHSANSTTNLAA---------IEPQPSPPHSEPPSVEQPPKPKL 578
+L V + NGS +AN + A E + SPP + + P P +
Sbjct: 942 MRLSVNTKPRIHMNGS-RNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI 1000
Query: 579 E---GVLVNHNEPRSSSRIGLRVHFNLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQ 635
G+L + + + ++G H+ AS+ AG + R Q R + Q
Sbjct: 1001 TNRYGLLPSGSLRLAQVQVGDSGHYE-------CTASNPAGSASHRYVL--GVQGRTSWQ 1051
Query: 636 ATKTPEPSSP 645
P P P
Sbjct: 1052 PQSLPVPHHP 1061
Score = 53.9 bits (128), Expect = 1e-06
Identities = 69/281 (24%), Positives = 104/281 (37%), Gaps = 54/281 (19%)
Query: 280 VPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRY 339
V G L C V+G P + W + + L S + Q +L SL I+ D GRY
Sbjct: 411 VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-RVAQLADL-SLEISGIIPTDGGRY 468
Query: 340 SCFASNIYGTD----------------STSAEIYIEGVS---SSDSEGDPN-----KEEM 375
C ASN G TS++ + +GV S + G P E
Sbjct: 469 QCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRES 528
Query: 376 NRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIA-- 433
+Q+ + + + +I P+ A CQ+ TN + G D + +
Sbjct: 529 QALQEDSRIHVDAQGTLIIQGVAPED---------AGNYSCQA-TNEV-GTDQETVTLYY 577
Query: 434 --APVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSM 491
P + + + + G+ V C G P P+V WYR G + +P
Sbjct: 578 TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAP------------ 625
Query: 492 AEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
E L I D+G +TC A N+ G S+ QL V
Sbjct: 626 -EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 665
Score = 48.1 bits (113), Expect = 5e-05
Identities = 48/203 (23%), Positives = 81/203 (39%), Gaps = 23/203 (11%)
Query: 1092 LDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYKCIATNK 1151
+ C V P L L G+ L + H +E+G S I ++ + GTY+C A ++
Sbjct: 329 VSCSVHSALPFRLQ-LRRGEARLGEERH---FQESGNSSWEILRASKAEEGTYECTAVSR 384
Query: 1152 TGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNET 1211
G ++ V + P N V G L CRV+G P W +D
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPA-----PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRV 439
Query: 1212 IPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQI 1271
+P + R++ D + L I +D G Y A N G+ + L + +
Sbjct: 440 LPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANGVTRASVWLLV------RE 489
Query: 1272 PPPMSVRPSGSRYGSLTSKGLDI 1294
P +S+ S + S+G+++
Sbjct: 490 APQVSIHTSSQHF----SQGVEV 508
Score = 39.7 bits (91), Expect = 0.019
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 10/91 (10%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVI 502
N++ S G+ V CRV G + W R D+R+L +A+ ++ +L I
Sbjct: 408 NVTVSPGETAVLSCRVLGEAPYNLTWVR---------DWRVLPASTGRVAQLADL-SLEI 457
Query: 503 AEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
+ + D G + C ASN G + L VR
Sbjct: 458 SGIIPTDGGRYQCVASNANGVTRASVWLLVR 488
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 105 bits (262), Expect = 3e-22
Identities = 98/326 (30%), Positives = 139/326 (42%), Gaps = 47/326 (14%)
Query: 959 GSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYT 1018
G V C+++G P+P ++W K+ + ++ ++ G +L I D G Y
Sbjct: 154 GDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSG--ALQISRLQPGDIGIYR 211
Query: 1019 IMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQA 1078
A NP S +G+ R+ S HR + +FLQ
Sbjct: 212 CSARNPAS--SRTGN------EAEVRILSDPGLHR------------------QLYFLQR 245
Query: 1079 PGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQ 1138
P ++VA EG+ L+C VSG PPP TW L G+ V+ S K + G +LLI +T
Sbjct: 246 PSNVVAIEGKDAVLECCVSGYPPPSFTW-LRGEEVIQLRSKKYSL--LGGSNLLISNVTD 302
Query: 1139 RDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGM 1198
D+G Y C+ T K S S EL+V+ P L N E + EC V G
Sbjct: 303 DDSGMYTCVVTYKNENISASAELTVLV-----PPWFLNHPSNLYAYESMDIEFECTVSGK 357
Query: 1199 PPPVFYWKKDNE-TIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSC 1257
P P W K+ + IP S + G + L I KSD G+Y A+NEAG
Sbjct: 358 PVPTVNWMKNGDVVIP------SDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQT 411
Query: 1258 TARLDIYAQWHHQIPPPMSVRPSGSR 1283
+A+L + P SV PS R
Sbjct: 412 SAQLIV----PKPAIPSSSVLPSAPR 433
Score = 73.6 bits (179), Expect = 1e-12
Identities = 81/336 (24%), Positives = 124/336 (36%), Gaps = 53/336 (15%)
Query: 947 FDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI 1006
F +R + EG C + G P P W + + I R++ + G +L I
Sbjct: 242 FLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLL----GGSNLLI 297
Query: 1007 ESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPL 1066
+ T DD G YT + IS S L V
Sbjct: 298 SNVTDDDSGMYTCVVTYKNENISASAELTV------------------------------ 327
Query: 1067 QERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRET 1126
P FL P ++ A+E +C VSG P P + W+ NG V+P +++
Sbjct: 328 ---LVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV---- 380
Query: 1127 GVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVP-- 1184
G +L I + + D G Y+C+A N+ G S +L +V K + +L VP
Sbjct: 381 GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL-IVPKPAIPSSSVLPSAPRDVVPVL 439
Query: 1185 -EGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQ--DTTGYACLLIQPAKKSDA 1241
VRL R PP T+ +RE + + +TT L +
Sbjct: 440 VSSRFVRLSWR----PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPE 495
Query: 1242 GWYT--LSAKNEAGIVSCTARLDIYAQWHHQIPPPM 1275
YT + A NE G + + + Q Q+P P+
Sbjct: 496 AMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPV 531
Score = 56.6 bits (135), Expect = 2e-07
Identities = 72/297 (24%), Positives = 106/297 (35%), Gaps = 50/297 (16%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLT 327
P RF + S G V L C V+G P P + W ++L P V +L
Sbjct: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQ 198
Query: 328 IAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPN-KEEMNRIQKPNEVSS 386
I+ D G Y C A N + T E + +S DP ++ +Q+P+ V +
Sbjct: 199 ISRLQPGDIGIYRCSARNP-ASSRTGNEAEVRILS------DPGLHRQLYFLQRPSNVVA 251
Query: 387 PPTTSAVI--------PPAVPQAQ-HLVAQPR-------------VATIQQCQS------ 418
AV+ PP+ + V Q R ++ + S
Sbjct: 252 IEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCV 311
Query: 419 ---PTNYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLI 475
+ ++ P F NL A E + FEC V G P P V W + G ++
Sbjct: 312 VTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVV 371
Query: 476 EDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHV 532
S F+I+ L I V D G + C A N+ G + AQL V
Sbjct: 372 IPSDYFQIVGGS-----------NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV 417
Score = 43.9 bits (102), Expect = 0.001
Identities = 52/188 (27%), Positives = 75/188 (39%), Gaps = 21/188 (11%)
Query: 1075 FLQAPGDMVAHEGRLCRLDCKV-SGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
FL P D V G LDC S P + W +G + + G SLLI
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNG--SLLI 99
Query: 1134 DPLTQR-----DAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPV-ILEKLQNCGVPEGH 1187
+ D G Y+C A+ +S S+ +S AK P+ L + ++ G
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLG---DSGSI-ISRTAKVAVAGPLRFLSQTESVTAFMGD 155
Query: 1188 PVRLECRVIGMPPPVFYWKKDNE---TIPCTRERISMHQDTTGYACLLIQPAKKSDAGWY 1244
V L+C VIG P P +W+K+ + IP + + L I + D G Y
Sbjct: 156 TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPS-----GALQISRLQPGDIGIY 210
Query: 1245 TLSAKNEA 1252
SA+N A
Sbjct: 211 RCSARNPA 218
Score = 40.8 bits (94), Expect = 0.009
Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 7/108 (6%)
Query: 943 IAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTC 1002
+ P F + E + F C + G PVP V W K+G + + + G
Sbjct: 329 VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYF-----QIVGGS 383
Query: 1003 SLHIESTTSDDDGNYTIMAANPQGRISCSGHLMV--QSLPIRSRLTSA 1048
+L I D+G Y +A N G S L+V ++P S L SA
Sbjct: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSA 431
Score = 35.4 bits (80), Expect = 0.36
Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 10/130 (7%)
Query: 429 KPIIAAPV-FTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
K +A P+ F ++++A G V+ +C V G P P + W + + D +
Sbjct: 133 KVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQK------NQQDLTPIPGD 186
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHSA 547
R + P L I+ + D G + C+A N + + + VR D + L+
Sbjct: 187 SRVVVLPSG--ALQISRLQPGDIGIYRCSARNPASSRTG-NEAEVRILSDPGLHRQLYFL 243
Query: 548 NSTTNLAAIE 557
+N+ AIE
Sbjct: 244 QRPSNVVAIE 253
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 102 bits (253), Expect = 3e-21
Identities = 89/317 (28%), Positives = 138/317 (43%), Gaps = 52/317 (16%)
Query: 958 EGSPVTFTCKIVGIPVPKVYWFK-DGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGN 1016
+G+ V C +G PVP + W + DGK I+++ R + +G L I + +D G
Sbjct: 239 KGATVKLECFALGNPVPTIIWRRADGKPIARKAR----RHKSNGI--LEIPNFQQEDAGL 292
Query: 1017 YTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFL 1076
Y +A N +G+ G L + +P+++
Sbjct: 293 YECVAENSRGKNVARGQLTF---------------------------------YAQPNWI 319
Query: 1077 QAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPL 1136
Q D+ +CK +G P P WL NG+P+L + + E G ++ I L
Sbjct: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLL---TRDRIQIEQGTLNITIVNL 376
Query: 1137 TQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVI 1196
+ DAG Y+C+A NK G + ELSV+A + +L+++ V G V +EC+
Sbjct: 377 S--DAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTL--VKVGGEVVIECKPK 432
Query: 1197 GMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVS 1256
P PV+ WKK + + ERI++ +D L I KSDAG YT A N G S
Sbjct: 433 ASPKPVYTWKKGRDILK-ENERITISEDGN----LRIINVTKSDAGSYTCIATNHFGTAS 487
Query: 1257 CTARLDIYAQWHHQIPP 1273
T L + +PP
Sbjct: 488 STGNLVVKDPTRVMVPP 504
Score = 79.7 bits (195), Expect = 2e-14
Identities = 72/266 (27%), Positives = 113/266 (42%), Gaps = 39/266 (14%)
Query: 1001 TCSLHIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQE 1060
T +L+I D GNYT + N + + H V P L + G +++
Sbjct: 176 TGNLYIAKVEKSDVGNYTCVVTN-----TVTNH-KVLGPPTPLILRNDGVMGEYEPKIE- 228
Query: 1061 RDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWL-LNGQPVLPDASH 1119
+Q P + +G +L+C G P P + W +G+P+ A
Sbjct: 229 ---------------VQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARR 273
Query: 1120 KMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ 1179
+ G+ L I Q DAG Y+C+A N G+N +L+ A+ P ++K+
Sbjct: 274 H---KSNGI--LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ-----PNWIQKIN 323
Query: 1180 NCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKS 1239
+ V V EC+ G P P + W K+ E + TR+RI + Q T L I S
Sbjct: 324 DIHVAMEENVFWECKANGRPKPTYKWLKNGEPL-LTRDRIQIEQGT-----LNITIVNLS 377
Query: 1240 DAGWYTLSAKNEAGIVSCTARLDIYA 1265
DAG Y A+N+ G++ A L + A
Sbjct: 378 DAGMYQCLAENKHGVIFSNAELSVIA 403
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/189 (29%), Positives = 81/189 (42%), Gaps = 27/189 (14%)
Query: 1073 PHFLQAPGDMVA---HEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
P F+Q P ++ E + +L+C+V G P P + W LNG V + V E +
Sbjct: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSL- 84
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQ-----NCGVP 1184
L+ +P +DAGTY+C ATN G ++V++E K L+ + V
Sbjct: 85 -LINNPNKTQDAGTYQCTATNSFG--------TIVSREAKLQFAYLDNFKTRTRSTVSVR 135
Query: 1185 EGHPVRLECRVIGMPP---PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDA 1241
G + L C G PP + Y NE R + Q+T L I +KSD
Sbjct: 136 RGQGMVLLC---GPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGN---LYIAKVEKSDV 189
Query: 1242 GWYTLSAKN 1250
G YT N
Sbjct: 190 GNYTCVVTN 198
Score = 55.1 bits (131), Expect = 4e-07
Identities = 82/325 (25%), Positives = 130/325 (40%), Gaps = 57/325 (17%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P + +++ V V + CK G P P W K+G+ + R+ +++ E GT L
Sbjct: 316 PNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRD---RIQIE-QGT--L 369
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSL-PIRSRLTSAGQSHRGRSRVQERDK 1063
+I D G Y +A N G I + L V ++ P SR
Sbjct: 370 NITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL----------------- 412
Query: 1064 EPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLV 1123
R ++ G++V ++CK P P TW G+ +L + + ++ +
Sbjct: 413 ------LKRVTLVKVGGEVV--------IECKPKASPKPVYTW-KKGRDILKE-NERITI 456
Query: 1124 RETGVHSLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGV 1183
E G +L I +T+ DAG+Y CIATN G S + L VK ++ + V
Sbjct: 457 SEDG--NLRIINVTKSDAGSYTCIATNHFGTASSTGNL-----VVKDPTRVMVPPSSMDV 509
Query: 1184 PEGHPVRLECRVI--GMPPPVFYWKKDNETIPCTR-----ERISMHQDTTGYACLLIQPA 1236
G + L C+V VF W + I R ER+ QD+ G L+I+
Sbjct: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVG-GQDSAG--DLMIRNI 566
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARL 1261
+ AG Y + +S A L
Sbjct: 567 QLKHAGKYVCMVQTSVDRLSAAADL 591
Score = 54.3 bits (129), Expect = 8e-07
Identities = 62/272 (22%), Positives = 101/272 (37%), Gaps = 35/272 (12%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWY-CEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYS 340
+G V+L+C +G P P + W +GK + H L I +ED G Y
Sbjct: 239 KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNG----ILEIPNFQQEDAGLYE 294
Query: 341 CFASNIYGTDSTSAEI-------YIEGVSSSDSEGDPN---KEEMNRIQKPN----EVSS 386
C A N G + ++ +I+ ++ + N + + N KP +
Sbjct: 295 CVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE 354
Query: 387 PPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNY---LQGLDGKPIIAAPVFTKMLQN 443
P T I + A + QC + + + I P F++ L
Sbjct: 355 PLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLK 414
Query: 444 --LSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLV 501
G VV EC+ K +P P W + +++++ I E L
Sbjct: 415 RVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITI-----------SEDGNLR 463
Query: 502 IAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
I V D+G +TC A+N +GT SS L V+
Sbjct: 464 IINVTKSDAGSYTCIATNHFGTASSTGNLVVK 495
Score = 50.8 bits (120), Expect = 8e-06
Identities = 76/321 (23%), Positives = 113/321 (35%), Gaps = 57/321 (17%)
Query: 957 TEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDD-G 1015
+E V C++ G P P + W +G + + EG SL I + D G
Sbjct: 41 SEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEG----SLLINNPNKTQDAG 96
Query: 1016 NYTIMAANPQGRI-SCSGHLMVQSLP-IRSRLTSAGQSHRGRSRVQERDKEPLQERFFRP 1073
Y A N G I S L L ++R S RG+ V P
Sbjct: 97 TYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPP-------- 148
Query: 1074 HFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLI 1133
H G L W+ N P D + + + +ETG +L I
Sbjct: 149 -----------HSGEL-------------SYAWIFNEYPSYQD-NRRFVSQETG--NLYI 181
Query: 1134 DPLTQRDAGTYKCIATNKTGQNS-------FSLELSVVAKEVKKAPVILEKLQNCGVPEG 1186
+ + D G Y C+ TN + L V E + + ++ + +G
Sbjct: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPK-IEVQFPETVPTAKG 240
Query: 1187 HPVRLECRVIGMPPPVFYWKK-DNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYT 1245
V+LEC +G P P W++ D + I R H+ L I ++ DAG Y
Sbjct: 241 ATVKLECFALGNPVPTIIWRRADGKPIARKARR---HKSN---GILEIPNFQQEDAGLYE 294
Query: 1246 LSAKNEAGIVSCTARLDIYAQ 1266
A+N G +L YAQ
Sbjct: 295 CVAENSRGKNVARGQLTFYAQ 315
Score = 49.3 bits (116), Expect = 2e-05
Identities = 55/213 (25%), Positives = 81/213 (38%), Gaps = 43/213 (20%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDG 1015
V G V CK P P VY +K G+ I K NE + +G+ L I + T D G
Sbjct: 419 VKVGGEVVIECKPKASPKP-VYTWKKGRDILKENERITISEDGN----LRIINVTKSDAG 473
Query: 1016 NYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHF 1075
+YT +A N G S +G+L+V K+P +
Sbjct: 474 SYTCIATNHFGTASSTGNLVV--------------------------KDPTR-------V 500
Query: 1076 LQAPGDMVAHEGRLCRLDCKVSGLPPPEL--TWLLNGQPVLPDASHKMLVRETGVHS--- 1130
+ P M G L C+V+ ++ TW NG + D R G S
Sbjct: 501 MVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGD 560
Query: 1131 LLIDPLTQRDAGTYKCIATNKTGQNSFSLELSV 1163
L+I + + AG Y C+ + S + +L V
Sbjct: 561 LMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV 593
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 9/80 (11%)
Query: 447 SEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVF 506
SE + V C VKG P P + W GT ++ DFR S+ E L+
Sbjct: 41 SEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRY------SVVEGS---LLINNPNK 91
Query: 507 AEDSGCFTCTASNKYGTVSS 526
+D+G + CTA+N +GT+ S
Sbjct: 92 TQDAGTYQCTATNSFGTIVS 111
Score = 44.7 bits (104), Expect = 6e-04
Identities = 74/381 (19%), Positives = 137/381 (35%), Gaps = 47/381 (12%)
Query: 214 PIPADTRDNEVNHALEQQEAKRREA---EQAASEAAGGDTTPGSSPSSLYYEEPLGQPPR 270
PI R ++ N LE ++ +A E A + G + G +Y +P
Sbjct: 266 PIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLT---FYAQP-----N 317
Query: 271 FTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAE 330
+ QK+ V V +C G P P +W G+ L I I Q +L I
Sbjct: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQG----TLNITI 373
Query: 331 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
D G Y C A N +G ++AE+ + V S + + ++ + P
Sbjct: 374 VNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKA 433
Query: 391 SAVIPPAVPQAQHLVAQPRVATIQQ------------------CQSPTNY-LQGLDGKPI 431
S + + ++ + TI + C + ++ G +
Sbjct: 434 SPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLV 493
Query: 432 IAAPVFTKML---QNLSASEGQLVVFECRVKGAPSPKV--EWYREGTLIEDSPDFRILQK 486
+ P T+++ ++ + G+ +V C+V S + W G LI+ D ++
Sbjct: 494 VKDP--TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFER 551
Query: 487 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSNNGSLHS 546
+ + L+I + + +G + C +S+ A L VRG ++
Sbjct: 552 ----VGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDE 607
Query: 547 ANSTTNLAAIEPQPSPPHSEP 567
TT A + +P P + P
Sbjct: 608 ITDTT--AQLSWRPGPDNHSP 626
Score = 42.0 bits (97), Expect = 0.004
Identities = 63/283 (22%), Positives = 106/283 (37%), Gaps = 48/283 (16%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDI-HIVQAGNLHSLTIAEAFEEDTGRYS 340
E +V+L+C V G P P +RW G +++ D + V G+L L +D G Y
Sbjct: 42 EEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSL--LINNPNKTQDAGTYQ 99
Query: 341 CFASNIYGT-DSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIP---- 395
C A+N +GT S A++ + + + + + R Q + PP S +
Sbjct: 100 CTATNSFGTIVSREAKLQFAYLDNFKTR-TRSTVSVRRGQGMVLLCGPPPHSGELSYAWI 158
Query: 396 ----PAVPQAQHLVAQPR----VATIQQCQ-------------------SPTNYLQGLDG 428
P+ + V+Q +A +++ PT + DG
Sbjct: 159 FNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDG 218
Query: 429 KPIIAAP-VFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKK 487
P + + + + ++G V EC G P P + W R D + + +K
Sbjct: 219 VMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRR--------ADGKPIARK 270
Query: 488 PRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQL 530
R + L I ED+G + C A N G + QL
Sbjct: 271 AR---RHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQL 310
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 100 bits (250), Expect = 7e-21
Identities = 95/344 (27%), Positives = 133/344 (38%), Gaps = 52/344 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F KR + VT F C+ G PVP V W KD ++ K R E +L
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS------RYEIRDDHTL 276
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T+ D G+YT +A N G+ S L VQ E
Sbjct: 277 KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----------------------GSE 313
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL------PDAS 1118
P PHF+ P D V GR C+ +G P P + W G L P +S
Sbjct: 314 P-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 366
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILE 1176
+ V +TG L I + + D G Y C N G LE++ V + + PVI +
Sbjct: 367 SRFSVSQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD-RPPPVIRQ 423
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1236
N V L C G P P W+KD + RI ++ L I+ A
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN----GVLQIRYA 479
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
K D G YT A +G + +A +++ ++ + PP P+
Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV-QEFGVPVQPPRPTDPN 522
Score = 91.3 bits (225), Expect = 6e-18
Identities = 82/330 (24%), Positives = 126/330 (38%), Gaps = 54/330 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI-----ESTT 1010
V++G P T CK G P P + W+K G+++ + + R + SL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D+G Y +A N G SH L+
Sbjct: 100 RPDEGVYVCVARNYLGE---------------------AVSHNAS----------LEVAI 128
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
R F Q P D++ G ++C+ G P P ++W +G P L D ++ +R
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--- 184
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPV 1189
L+I + DAG Y C+ TN G+ E V V + P +++ N V
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGER----ESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+C G P P W+KD+ +P + R + D T L I+ D G YT A+
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHT----LKIRKVTAGDMGSYTCVAE 294
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
N G +A L + PP V+P
Sbjct: 295 NMVGKAEASATLTVQV---GSEPPHFVVKP 321
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 21/198 (10%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD----ASHKM 1121
L++ F P ++ P D++ +G L+CK G P P + W G+ V D SH+M
Sbjct: 22 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81
Query: 1122 LVRETGVHSLLI--DPLTQRDAGTYKCIATNKTGQ---NSFSLELSVVAKEVKKAPVILE 1176
L+ + L I ++ D G Y C+A N G+ ++ SLE++++ + ++ P
Sbjct: 82 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP---- 137
Query: 1177 KLQNCGVPEGHPVRLECR-VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQP 1235
+ V G P +EC+ G P P WKKD + ERI++ L+I
Sbjct: 138 --SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190
Query: 1236 AKKSDAGWYTLSAKNEAG 1253
+KSDAG Y N G
Sbjct: 191 TRKSDAGKYVCVGTNMVG 208
Score = 64.7 bits (156), Expect = 6e-10
Identities = 71/295 (24%), Positives = 109/295 (36%), Gaps = 42/295 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE---NSPDIH--IVQAGN 322
PPR + V +G L+C G P P + WY G+ +E + P H ++ +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 323 LHSLTIAEAFEE--DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
L L I + D G Y C A N G ++ S +E D + M + +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 381 PNEVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQCQSPTNYLQGLD-GK-------- 429
P + P P L + TI+ + Y + D GK
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 430 -----------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
++ P F K NL+ + F+C +G P P V W ++ +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--- 263
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
P+S E + TL I +V A D G +TC A N G + A L V+
Sbjct: 264 ---------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 48.5 bits (114), Expect = 4e-05
Identities = 62/275 (22%), Positives = 89/275 (32%), Gaps = 88/275 (32%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE--------LENSPDIHIV 318
+PP F K R + V G V C G P P + W EG + ++S +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
Q G+ LTI D G Y C N+ G+ T A + + V
Sbjct: 373 QTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV----------------- 412
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFT 438
++ P PP + Q P N +DG
Sbjct: 413 -----IADRP------PPVIR-----------------QGPVNQTVAVDG---------- 434
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
V C G+P P + W ++G L+ + D RI Q E
Sbjct: 435 ------------TFVLSCVATGSPVPTILWRKDGVLV-STQDSRIKQL---------ENG 472
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I D+G +TC AS G + A + V+
Sbjct: 473 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS--MAEPEE---I 497
+L S+G+ C+ +G P+P +EWY+ G +E D PRS M P
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD------DPRSHRMLLPSGSLFF 90
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+V D G + C A N G VS A L V D + A +
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 557 EPQPSPPHSEP 567
E QP H EP
Sbjct: 151 ECQPPRGHPEP 161
Score = 40.8 bits (94), Expect = 0.009
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
+GT V L C+ G P P + W +G L ++ D I Q N L I A DTGRY+C
Sbjct: 433 DGTFV-LSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLEN-GVLQIRYAKLGDTGRYTC 489
Query: 342 FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
AS G + SA YIE P + N I P+ S P T
Sbjct: 490 IASTPSGEATWSA--YIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVT 534
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 100 bits (250), Expect = 7e-21
Identities = 95/344 (27%), Positives = 133/344 (38%), Gaps = 52/344 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F KR + VT F C+ G PVP V W KD ++ K R E +L
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS------RYEIRDDHTL 276
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T+ D G+YT +A N G+ S L VQ E
Sbjct: 277 KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----------------------GSE 313
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL------PDAS 1118
P PHF+ P D V GR C+ +G P P + W G L P +S
Sbjct: 314 P-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 366
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILE 1176
+ V +TG L I + + D G Y C N G LE++ V + + PVI +
Sbjct: 367 SRFSVSQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD-RPPPVIRQ 423
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1236
N V L C G P P W+KD + RI ++ L I+ A
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN----GVLQIRYA 479
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
K D G YT A +G + +A +++ ++ + PP P+
Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV-QEFGVPVQPPRPTDPN 522
Score = 91.3 bits (225), Expect = 6e-18
Identities = 82/330 (24%), Positives = 126/330 (38%), Gaps = 54/330 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI-----ESTT 1010
V++G P T CK G P P + W+K G+++ + + R + SL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D+G Y +A N G SH L+
Sbjct: 100 RPDEGVYVCVARNYLGE---------------------AVSHNAS----------LEVAI 128
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
R F Q P D++ G ++C+ G P P ++W +G P L D ++ +R
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--- 184
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPV 1189
L+I + DAG Y C+ TN G+ E V V + P +++ N V
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGER----ESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+C G P P W+KD+ +P + R + D T L I+ D G YT A+
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHT----LKIRKVTAGDMGSYTCVAE 294
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
N G +A L + PP V+P
Sbjct: 295 NMVGKAEASATLTVQV---GSEPPHFVVKP 321
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 21/198 (10%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD----ASHKM 1121
L++ F P ++ P D++ +G L+CK G P P + W G+ V D SH+M
Sbjct: 22 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81
Query: 1122 LVRETGVHSLLI--DPLTQRDAGTYKCIATNKTGQ---NSFSLELSVVAKEVKKAPVILE 1176
L+ + L I ++ D G Y C+A N G+ ++ SLE++++ + ++ P
Sbjct: 82 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP---- 137
Query: 1177 KLQNCGVPEGHPVRLECR-VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQP 1235
+ V G P +EC+ G P P WKKD + ERI++ L+I
Sbjct: 138 --SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190
Query: 1236 AKKSDAGWYTLSAKNEAG 1253
+KSDAG Y N G
Sbjct: 191 TRKSDAGKYVCVGTNMVG 208
Score = 64.7 bits (156), Expect = 6e-10
Identities = 71/295 (24%), Positives = 109/295 (36%), Gaps = 42/295 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE---NSPDIH--IVQAGN 322
PPR + V +G L+C G P P + WY G+ +E + P H ++ +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 323 LHSLTIAEAFEE--DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
L L I + D G Y C A N G ++ S +E D + M + +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 381 PNEVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQCQSPTNYLQGLD-GK-------- 429
P + P P L + TI+ + Y + D GK
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 430 -----------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
++ P F K NL+ + F+C +G P P V W ++ +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--- 263
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
P+S E + TL I +V A D G +TC A N G + A L V+
Sbjct: 264 ---------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 48.5 bits (114), Expect = 4e-05
Identities = 62/275 (22%), Positives = 89/275 (32%), Gaps = 88/275 (32%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE--------LENSPDIHIV 318
+PP F K R + V G V C G P P + W EG + ++S +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
Q G+ LTI D G Y C N+ G+ T A + + V
Sbjct: 373 QTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV----------------- 412
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFT 438
++ P PP + Q P N +DG
Sbjct: 413 -----IADRP------PPVIR-----------------QGPVNQTVAVDG---------- 434
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
V C G+P P + W ++G L+ + D RI Q E
Sbjct: 435 ------------TFVLSCVATGSPVPTILWRKDGVLV-STQDSRIKQL---------ENG 472
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I D+G +TC AS G + A + V+
Sbjct: 473 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS--MAEPEE---I 497
+L S+G+ C+ +G P+P +EWY+ G +E D PRS M P
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD------DPRSHRMLLPSGSLFF 90
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+V D G + C A N G VS A L V D + A +
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 557 EPQPSPPHSEP 567
E QP H EP
Sbjct: 151 ECQPPRGHPEP 161
Score = 40.8 bits (94), Expect = 0.009
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
+GT V L C+ G P P + W +G L ++ D I Q N L I A DTGRY+C
Sbjct: 433 DGTFV-LSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLEN-GVLQIRYAKLGDTGRYTC 489
Query: 342 FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
AS G + SA YIE P + N I P+ S P T
Sbjct: 490 IASTPSGEATWSA--YIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVT 534
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 100 bits (250), Expect = 7e-21
Identities = 95/344 (27%), Positives = 133/344 (38%), Gaps = 55/344 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F KR + VT F C+ G PVP V W KD ++ K R E +L
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS------RYEIRDDHTL 276
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T+ D G+YT +A N G+ S L VQ E
Sbjct: 277 KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ--------------------------E 310
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL------PDAS 1118
P PHF+ P D V GR C+ +G P P + W G L P +S
Sbjct: 311 P-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 363
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILE 1176
+ V +TG L I + + D G Y C N G LE++ V + + PVI +
Sbjct: 364 SRFSVSQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD-RPPPVIRQ 420
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1236
N V L C G P P W+KD + RI ++ L I+ A
Sbjct: 421 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN----GVLQIRYA 476
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
K D G YT A +G + +A +++ ++ + PP P+
Sbjct: 477 KLGDTGRYTCIASTPSGEATWSAYIEV-QEFGVPVQPPRPTDPN 519
Score = 93.2 bits (230), Expect = 1e-18
Identities = 83/330 (25%), Positives = 127/330 (38%), Gaps = 57/330 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI-----ESTT 1010
V++G P T CK G P P + W+K G+++ + + R + SL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D+G Y +A N G SH L+
Sbjct: 100 RPDEGVYVCVARNYLGE---------------------AVSHNAS----------LEVAI 128
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
R F Q P D++ G ++C+ G P P ++W +G P L D ++ +R
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--- 184
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPV 1189
L+I + DAG Y C+ TN G+ E V V + P +++ N V
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGER----ESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+C G P P W+KD+ +P + R + D T L I+ D G YT A+
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHT----LKIRKVTAGDMGSYTCVAE 294
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
N G +A L + Q PP V+P
Sbjct: 295 NMVGKAEASATLTV------QEPPHFVVKP 318
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 21/198 (10%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD----ASHKM 1121
L++ F P ++ P D++ +G L+CK G P P + W G+ V D SH+M
Sbjct: 22 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81
Query: 1122 LVRETGVHSLLI--DPLTQRDAGTYKCIATNKTGQ---NSFSLELSVVAKEVKKAPVILE 1176
L+ + L I ++ D G Y C+A N G+ ++ SLE++++ + ++ P
Sbjct: 82 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP---- 137
Query: 1177 KLQNCGVPEGHPVRLECR-VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQP 1235
+ V G P +EC+ G P P WKKD + ERI++ L+I
Sbjct: 138 --SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190
Query: 1236 AKKSDAGWYTLSAKNEAG 1253
+KSDAG Y N G
Sbjct: 191 TRKSDAGKYVCVGTNMVG 208
Score = 64.7 bits (156), Expect = 6e-10
Identities = 71/295 (24%), Positives = 109/295 (36%), Gaps = 42/295 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE---NSPDIH--IVQAGN 322
PPR + V +G L+C G P P + WY G+ +E + P H ++ +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 323 LHSLTIAEAFEE--DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
L L I + D G Y C A N G ++ S +E D + M + +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 381 PNEVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQCQSPTNYLQGLD-GK-------- 429
P + P P L + TI+ + Y + D GK
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 430 -----------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
++ P F K NL+ + F+C +G P P V W ++ +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--- 263
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
P+S E + TL I +V A D G +TC A N G + A L V+
Sbjct: 264 ---------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 48.5 bits (114), Expect = 4e-05
Identities = 62/275 (22%), Positives = 89/275 (32%), Gaps = 88/275 (32%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE--------LENSPDIHIV 318
+PP F K R + V G V C G P P + W EG + ++S +
Sbjct: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
Q G+ LTI D G Y C N+ G+ T A + + V
Sbjct: 370 QTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV----------------- 409
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFT 438
++ P PP + Q P N +DG
Sbjct: 410 -----IADRP------PPVIR-----------------QGPVNQTVAVDG---------- 431
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
V C G+P P + W ++G L+ + D RI Q E
Sbjct: 432 ------------TFVLSCVATGSPVPTILWRKDGVLV-STQDSRIKQL---------ENG 469
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I D+G +TC AS G + A + V+
Sbjct: 470 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS--MAEPEE---I 497
+L S+G+ C+ +G P+P +EWY+ G +E D PRS M P
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD------DPRSHRMLLPSGSLFF 90
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+V D G + C A N G VS A L V D + A +
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 557 EPQPSPPHSEP 567
E QP H EP
Sbjct: 151 ECQPPRGHPEP 161
Score = 40.8 bits (94), Expect = 0.009
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
+GT V L C+ G P P + W +G L ++ D I Q N L I A DTGRY+C
Sbjct: 430 DGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRYTC 486
Query: 342 FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
AS G + SA YIE P + N I P+ S P T
Sbjct: 487 IASTPSGEATWSA--YIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVT 531
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 100 bits (250), Expect = 7e-21
Identities = 95/344 (27%), Positives = 133/344 (38%), Gaps = 52/344 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F KR + VT F C+ G PVP V W KD ++ K R E +L
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS------RYEIRDDHTL 276
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T+ D G+YT +A N G+ S L VQ E
Sbjct: 277 KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----------------------GSE 313
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL------PDAS 1118
P PHF+ P D V GR C+ +G P P + W G L P +S
Sbjct: 314 P-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 366
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILE 1176
+ V +TG L I + + D G Y C N G LE++ V + + PVI +
Sbjct: 367 SRFSVSQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD-RPPPVIRQ 423
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1236
N V L C G P P W+KD + RI ++ L I+ A
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN----GVLQIRYA 479
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
K D G YT A +G + +A +++ ++ + PP P+
Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV-QEFGVPVQPPRPTDPN 522
Score = 91.3 bits (225), Expect = 6e-18
Identities = 82/330 (24%), Positives = 126/330 (38%), Gaps = 54/330 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI-----ESTT 1010
V++G P T CK G P P + W+K G+++ + + R + SL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D+G Y +A N G SH L+
Sbjct: 100 RPDEGVYVCVARNYLGE---------------------AVSHNAS----------LEVAI 128
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
R F Q P D++ G ++C+ G P P ++W +G P L D ++ +R
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--- 184
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPV 1189
L+I + DAG Y C+ TN G+ E V V + P +++ N V
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGER----ESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+C G P P W+KD+ +P + R + D T L I+ D G YT A+
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHT----LKIRKVTAGDMGSYTCVAE 294
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
N G +A L + PP V+P
Sbjct: 295 NMVGKAEASATLTVQV---GSEPPHFVVKP 321
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 21/198 (10%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD----ASHKM 1121
L++ F P ++ P D++ +G L+CK G P P + W G+ V D SH+M
Sbjct: 22 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81
Query: 1122 LVRETGVHSLLI--DPLTQRDAGTYKCIATNKTGQ---NSFSLELSVVAKEVKKAPVILE 1176
L+ + L I ++ D G Y C+A N G+ ++ SLE++++ + ++ P
Sbjct: 82 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP---- 137
Query: 1177 KLQNCGVPEGHPVRLECR-VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQP 1235
+ V G P +EC+ G P P WKKD + ERI++ L+I
Sbjct: 138 --SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190
Query: 1236 AKKSDAGWYTLSAKNEAG 1253
+KSDAG Y N G
Sbjct: 191 TRKSDAGKYVCVGTNMVG 208
Score = 64.7 bits (156), Expect = 6e-10
Identities = 71/295 (24%), Positives = 109/295 (36%), Gaps = 42/295 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE---NSPDIH--IVQAGN 322
PPR + V +G L+C G P P + WY G+ +E + P H ++ +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 323 LHSLTIAEAFEE--DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
L L I + D G Y C A N G ++ S +E D + M + +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 381 PNEVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQCQSPTNYLQGLD-GK-------- 429
P + P P L + TI+ + Y + D GK
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 430 -----------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
++ P F K NL+ + F+C +G P P V W ++ +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--- 263
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
P+S E + TL I +V A D G +TC A N G + A L V+
Sbjct: 264 ---------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 48.5 bits (114), Expect = 4e-05
Identities = 62/275 (22%), Positives = 89/275 (32%), Gaps = 88/275 (32%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE--------LENSPDIHIV 318
+PP F K R + V G V C G P P + W EG + ++S +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
Q G+ LTI D G Y C N+ G+ T A + + V
Sbjct: 373 QTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV----------------- 412
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFT 438
++ P PP + Q P N +DG
Sbjct: 413 -----IADRP------PPVIR-----------------QGPVNQTVAVDG---------- 434
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
V C G+P P + W ++G L+ + D RI Q E
Sbjct: 435 ------------TFVLSCVATGSPVPTILWRKDGVLV-STQDSRIKQL---------ENG 472
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I D+G +TC AS G + A + V+
Sbjct: 473 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS--MAEPEE---I 497
+L S+G+ C+ +G P+P +EWY+ G +E D PRS M P
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD------DPRSHRMLLPSGSLFF 90
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+V D G + C A N G VS A L V D + A +
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 557 EPQPSPPHSEP 567
E QP H EP
Sbjct: 151 ECQPPRGHPEP 161
Score = 40.8 bits (94), Expect = 0.009
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
+GT V L C+ G P P + W +G L ++ D I Q N L I A DTGRY+C
Sbjct: 433 DGTFV-LSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLEN-GVLQIRYAKLGDTGRYTC 489
Query: 342 FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
AS G + SA YIE P + N I P+ S P T
Sbjct: 490 IASTPSGEATWSA--YIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVT 534
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 100 bits (250), Expect = 7e-21
Identities = 95/344 (27%), Positives = 133/344 (38%), Gaps = 52/344 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F KR + VT F C+ G PVP V W KD ++ K R E +L
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS------RYEIRDDHTL 276
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T+ D G+YT +A N G+ S L VQ E
Sbjct: 277 KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----------------------GSE 313
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL------PDAS 1118
P PHF+ P D V GR C+ +G P P + W G L P +S
Sbjct: 314 P-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 366
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILE 1176
+ V +TG L I + + D G Y C N G LE++ V + + PVI +
Sbjct: 367 SRFSVSQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD-RPPPVIRQ 423
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1236
N V L C G P P W+KD + RI ++ L I+ A
Sbjct: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN----GVLQIRYA 479
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
K D G YT A +G + +A +++ ++ + PP P+
Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV-QEFGVPVQPPRPTDPN 522
Score = 91.3 bits (225), Expect = 6e-18
Identities = 82/330 (24%), Positives = 126/330 (38%), Gaps = 54/330 (16%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI-----ESTT 1010
V++G P T CK G P P + W+K G+++ + + R + SL +
Sbjct: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 99
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D+G Y +A N G SH L+
Sbjct: 100 RPDEGVYVCVARNYLGE---------------------AVSHNAS----------LEVAI 128
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
R F Q P D++ G ++C+ G P P ++W +G P L D ++ +R
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--- 184
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPV 1189
L+I + DAG Y C+ TN G+ E V V + P +++ N V
Sbjct: 185 KLMITYTRKSDAGKYVCVGTNMVGER----ESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+C G P P W+KD+ +P + R + D T L I+ D G YT A+
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHT----LKIRKVTAGDMGSYTCVAE 294
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
N G +A L + PP V+P
Sbjct: 295 NMVGKAEASATLTVQV---GSEPPHFVVKP 321
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 21/198 (10%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD----ASHKM 1121
L++ F P ++ P D++ +G L+CK G P P + W G+ V D SH+M
Sbjct: 22 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 81
Query: 1122 LVRETGVHSLLI--DPLTQRDAGTYKCIATNKTGQ---NSFSLELSVVAKEVKKAPVILE 1176
L+ + L I ++ D G Y C+A N G+ ++ SLE++++ + ++ P
Sbjct: 82 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP---- 137
Query: 1177 KLQNCGVPEGHPVRLECR-VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQP 1235
+ V G P +EC+ G P P WKKD + ERI++ L+I
Sbjct: 138 --SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 190
Query: 1236 AKKSDAGWYTLSAKNEAG 1253
+KSDAG Y N G
Sbjct: 191 TRKSDAGKYVCVGTNMVG 208
Score = 64.7 bits (156), Expect = 6e-10
Identities = 71/295 (24%), Positives = 109/295 (36%), Gaps = 42/295 (14%)
Query: 268 PPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKELE---NSPDIH--IVQAGN 322
PPR + V +G L+C G P P + WY G+ +E + P H ++ +G+
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 323 LHSLTIAEAFEE--DTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQK 380
L L I + D G Y C A N G ++ S +E D + M + +
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 381 PNEVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQCQSPTNYLQGLD-GK-------- 429
P + P P L + TI+ + Y + D GK
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 430 -----------PIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDS 478
++ P F K NL+ + F+C +G P P V W ++ +
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--- 263
Query: 479 PDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
P+S E + TL I +V A D G +TC A N G + A L V+
Sbjct: 264 ---------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Score = 48.5 bits (114), Expect = 4e-05
Identities = 62/275 (22%), Positives = 89/275 (32%), Gaps = 88/275 (32%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE--------LENSPDIHIV 318
+PP F K R + V G V C G P P + W EG + ++S +
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
Q G+ LTI D G Y C N+ G+ T A + + V
Sbjct: 373 QTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV----------------- 412
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFT 438
++ P PP + Q P N +DG
Sbjct: 413 -----IADRP------PPVIR-----------------QGPVNQTVAVDG---------- 434
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
V C G+P P + W ++G L+ + D RI Q E
Sbjct: 435 ------------TFVLSCVATGSPVPTILWRKDGVLV-STQDSRIKQL---------ENG 472
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I D+G +TC AS G + A + V+
Sbjct: 473 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS--MAEPEE---I 497
+L S+G+ C+ +G P+P +EWY+ G +E D PRS M P
Sbjct: 37 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD------DPRSHRMLLPSGSLFF 90
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+V D G + C A N G VS A L V D + A +
Sbjct: 91 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 557 EPQPSPPHSEP 567
E QP H EP
Sbjct: 151 ECQPPRGHPEP 161
Score = 40.8 bits (94), Expect = 0.009
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
+GT V L C+ G P P + W +G L ++ D I Q N L I A DTGRY+C
Sbjct: 433 DGTFV-LSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLEN-GVLQIRYAKLGDTGRYTC 489
Query: 342 FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
AS G + SA YIE P + N I P+ S P T
Sbjct: 490 IASTPSGEATWSA--YIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVT 534
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 100 bits (250), Expect = 7e-21
Identities = 95/344 (27%), Positives = 133/344 (38%), Gaps = 55/344 (15%)
Query: 945 PIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSL 1004
P F KR + VT F C+ G PVP V W KD ++ K R E +L
Sbjct: 262 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS------RYEIRDDHTL 315
Query: 1005 HIESTTSDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKE 1064
I T+ D G+YT +A N G+ S L VQ E
Sbjct: 316 KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ--------------------------E 349
Query: 1065 PLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVL------PDAS 1118
P PHF+ P D V GR C+ +G P P + W G L P +S
Sbjct: 350 P-------PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 402
Query: 1119 HKMLVRETGVHSLLIDPLTQRDAGTYKCIATNKTGQ--NSFSLELSVVAKEVKKAPVILE 1176
+ V +TG L I + + D G Y C N G LE++ V + + PVI +
Sbjct: 403 SRFSVSQTG--DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD-RPPPVIRQ 459
Query: 1177 KLQNCGVPEGHPVRLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPA 1236
N V L C G P P W+KD + RI ++ L I+ A
Sbjct: 460 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLEN----GVLQIRYA 515
Query: 1237 KKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHHQIPPPMSVRPS 1280
K D G YT A +G + +A +++ ++ + PP P+
Sbjct: 516 KLGDTGRYTCIASTPSGEATWSAYIEV-QEFGVPVQPPRPTDPN 558
Score = 93.2 bits (230), Expect = 1e-18
Identities = 83/330 (25%), Positives = 127/330 (38%), Gaps = 57/330 (17%)
Query: 956 VTEGSPVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHI-----ESTT 1010
V++G P T CK G P P + W+K G+++ + + R + SL +
Sbjct: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKS 138
Query: 1011 SDDDGNYTIMAANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERF 1070
D+G Y +A N G SH L+
Sbjct: 139 RPDEGVYVCVARNYLGE---------------------AVSHNAS----------LEVAI 167
Query: 1071 FRPHFLQAPGDMVAHEGRLCRLDCKVS-GLPPPELTWLLNGQPVLPDASHKMLVRETGVH 1129
R F Q P D++ G ++C+ G P P ++W +G P L D ++ +R
Sbjct: 168 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--- 223
Query: 1130 SLLIDPLTQRDAGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPV 1189
L+I + DAG Y C+ TN G+ E V V + P +++ N V
Sbjct: 224 KLMITYTRKSDAGKYVCVGTNMVGER----ESEVAELTVLERPSFVKRPSNLAVTVDDSA 279
Query: 1190 RLECRVIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAK 1249
+C G P P W+KD+ +P + R + D T L I+ D G YT A+
Sbjct: 280 EFKCEARGDPVPTVRWRKDDGELP--KSRYEIRDDHT----LKIRKVTAGDMGSYTCVAE 333
Query: 1250 NEAGIVSCTARLDIYAQWHHQIPPPMSVRP 1279
N G +A L + Q PP V+P
Sbjct: 334 NMVGKAEASATLTV------QEPPHFVVKP 357
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 21/198 (10%)
Query: 1066 LQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPD----ASHKM 1121
L++ F P ++ P D++ +G L+CK G P P + W G+ V D SH+M
Sbjct: 61 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 120
Query: 1122 LVRETGVHSLLI--DPLTQRDAGTYKCIATNKTGQ---NSFSLELSVVAKEVKKAPVILE 1176
L+ + L I ++ D G Y C+A N G+ ++ SLE++++ + ++ P
Sbjct: 121 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP---- 176
Query: 1177 KLQNCGVPEGHPVRLECR-VIGMPPPVFYWKKDNETIPCTRERISMHQDTTGYACLLIQP 1235
+ V G P +EC+ G P P WKKD + ERI++ L+I
Sbjct: 177 --SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-----LMITY 229
Query: 1236 AKKSDAGWYTLSAKNEAG 1253
+KSDAG Y N G
Sbjct: 230 TRKSDAGKYVCVGTNMVG 247
Score = 65.1 bits (157), Expect = 4e-10
Identities = 76/314 (24%), Positives = 117/314 (37%), Gaps = 45/314 (14%)
Query: 249 DTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE 308
D + G + S L E+ PPR + V +G L+C G P P + WY G+
Sbjct: 51 DNSLGYTGSRLRQED---FPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 107
Query: 309 LE---NSPDIH--IVQAGNLHSLTIAEAFEE--DTGRYSCFASNIYGTDSTSAEIYIEGV 361
+E + P H ++ +G+L L I + D G Y C A N G ++ S +E
Sbjct: 108 VETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVA 166
Query: 362 SSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAV--PQAQHLVAQPRVATIQQCQSP 419
D + M + +P + P P L + TI+ +
Sbjct: 167 ILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 226
Query: 420 TNYLQGLD-GK-------------------PIIAAPVFTKMLQNLSASEGQLVVFECRVK 459
Y + D GK ++ P F K NL+ + F+C +
Sbjct: 227 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 286
Query: 460 GAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASN 519
G P P V W ++ + P+S E + TL I +V A D G +TC A N
Sbjct: 287 GDPVPTVRWRKDDGEL------------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 334
Query: 520 KYGTVSSIAQLHVR 533
G + A L V+
Sbjct: 335 MVGKAEASATLTVQ 348
Score = 48.5 bits (114), Expect = 4e-05
Identities = 62/275 (22%), Positives = 89/275 (32%), Gaps = 88/275 (32%)
Query: 267 QPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQVRWYCEGKE--------LENSPDIHIV 318
+PP F K R + V G V C G P P + W EG + ++S +
Sbjct: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
Query: 319 QAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRI 378
Q G+ LTI D G Y C N+ G+ T A + + V
Sbjct: 409 QTGD---LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV----------------- 448
Query: 379 QKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPTNYLQGLDGKPIIAAPVFT 438
++ P PP + Q P N +DG
Sbjct: 449 -----IADRP------PPVIR-----------------QGPVNQTVAVDG---------- 470
Query: 439 KMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEIC 498
V C G+P P + W ++G L+ + D RI Q E
Sbjct: 471 ------------TFVLSCVATGSPVPTILWRKDGVLV-STQDSRIKQL---------ENG 508
Query: 499 TLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVR 533
L I D+G +TC AS G + A + V+
Sbjct: 509 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/131 (29%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 443 NLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRS--MAEPEE---I 497
+L S+G+ C+ +G P+P +EWY+ G +E D PRS M P
Sbjct: 76 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKD------DPRSHRMLLPSGSLFF 129
Query: 498 CTLVIAEVFAEDSGCFTCTASNKYG-TVSSIAQLHVRGNEDLSNNGSLHSANSTTNLAAI 556
+V D G + C A N G VS A L V D + A +
Sbjct: 130 LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 189
Query: 557 EPQPSPPHSEP 567
E QP H EP
Sbjct: 190 ECQPPRGHPEP 200
Score = 40.8 bits (94), Expect = 0.009
Identities = 39/109 (35%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 282 EGTRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC 341
+GT V L C+ G P P + W +G L ++ D I Q N L I A DTGRY+C
Sbjct: 469 DGTFV-LSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRYTC 525
Query: 342 FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTT 390
AS G + SA YIE P + N I P+ S P T
Sbjct: 526 IASTPSGEATWSA--YIEVQEFGVPVQPPRPTDPNLI--PSAPSKPEVT 570
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,581,277
Number of Sequences: 37866
Number of extensions: 3413588
Number of successful extensions: 28280
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 269
Number of HSP's successfully gapped in prelim test: 855
Number of HSP's that attempted gapping in prelim test: 14496
Number of HSP's gapped (non-prelim): 9793
length of query: 1320
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1206
effective length of database: 13,930,794
effective search space: 16800537564
effective search space used: 16800537564
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.