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Search of human proteins with 153791628
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791628 MCF.2 cell line derived transforming sequence
isoform a [Homo sapiens]
(985 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 1976 0.0
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 1826 0.0
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 845 0.0
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 845 0.0
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 631 e-180
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 229 7e-60
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 226 8e-59
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 218 3e-56
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 192 1e-48
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 184 5e-46
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 184 5e-46
gi|148529025 pleckstrin homology domain containing, family G (wi... 182 1e-45
gi|193211603 pleckstrin homology domain containing, family G (wi... 176 7e-44
gi|193211598 pleckstrin homology domain containing, family G (wi... 176 7e-44
gi|193211596 pleckstrin homology domain containing, family G (wi... 176 7e-44
gi|193211594 pleckstrin homology domain containing, family G (wi... 176 7e-44
gi|55742734 pleckstrin homology domain containing, family G (wit... 176 7e-44
gi|71274148 pleckstrin homology domain containing, family G (wit... 139 2e-32
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 134 3e-31
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 134 3e-31
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 113 1e-24
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 105 3e-22
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 103 6e-22
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 103 6e-22
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 99 1e-20
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 98 4e-20
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 90 9e-18
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 90 9e-18
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 90 9e-18
gi|55749621 pleckstrin homology domain containing, family G, mem... 86 1e-16
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 1976 bits (5120), Expect = 0.0
Identities = 985/985 (100%), Positives = 985/985 (100%)
Query: 1 MQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILD 60
MQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILD
Sbjct: 1 MQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILD 60
Query: 61 RRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVM 120
RRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVM
Sbjct: 61 RRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVM 120
Query: 121 LSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELA 180
LSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELA
Sbjct: 121 LSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELA 180
Query: 181 ETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
ETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR
Sbjct: 181 ETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
Query: 241 QISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQ 300
QISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQ
Sbjct: 241 QISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQ 300
Query: 301 QAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRC 360
QAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRC
Sbjct: 301 QAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRC 360
Query: 361 NELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQ 420
NELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQ
Sbjct: 361 NELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQ 420
Query: 421 KALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAG 480
KALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAG
Sbjct: 421 KALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAG 480
Query: 481 FRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS 540
FRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS
Sbjct: 481 FRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS 540
Query: 541 GPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRN 600
GPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRN
Sbjct: 541 GPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRN 600
Query: 601 KKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSET 660
KKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSET
Sbjct: 601 KKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSET 660
Query: 661 IWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKK 720
IWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKK
Sbjct: 661 IWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKK 720
Query: 721 ALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFK 780
ALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFK
Sbjct: 721 ALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFK 780
Query: 781 PMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWY 840
PMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWY
Sbjct: 781 PMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWY 840
Query: 841 GEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQND 900
GEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQND
Sbjct: 841 GEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQND 900
Query: 901 EKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYF 960
EKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYF
Sbjct: 901 EKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYF 960
Query: 961 YPTYDENEEENRPLMRPVSEMALLY 985
YPTYDENEEENRPLMRPVSEMALLY
Sbjct: 961 YPTYDENEEENRPLMRPVSEMALLY 985
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 1826 bits (4729), Expect = 0.0
Identities = 909/916 (99%), Positives = 913/916 (99%)
Query: 70 KISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLT 129
K+ ++ +ASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLT
Sbjct: 10 KMRFRRNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLT 69
Query: 130 YIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIP 189
YIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIP
Sbjct: 70 YIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIP 129
Query: 190 SIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTI 249
SIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTI
Sbjct: 130 SIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTI 189
Query: 250 NKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG 309
NKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG
Sbjct: 190 NKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG 249
Query: 310 TIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDI 369
TIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDI
Sbjct: 250 TIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDI 309
Query: 370 LVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENF 429
LVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENF
Sbjct: 310 LVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENF 369
Query: 430 LEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHV 489
LEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHV
Sbjct: 370 LEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHV 429
Query: 490 RPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNG 549
RPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNG
Sbjct: 430 RPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNG 489
Query: 550 NSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNM 609
NSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNM
Sbjct: 490 NSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNM 549
Query: 610 AEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECA 669
AEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECA
Sbjct: 550 AEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECA 609
Query: 670 FFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLL 729
FFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLL
Sbjct: 610 FFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLL 669
Query: 730 KSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLY 789
KSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLY
Sbjct: 670 KSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLY 729
Query: 790 EKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIV 849
EKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIV
Sbjct: 730 EKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIV 789
Query: 850 QASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFIS 909
QASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFIS
Sbjct: 790 QASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFIS 849
Query: 910 TEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEE 969
TEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEE
Sbjct: 850 TEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEE 909
Query: 970 ENRPLMRPVSEMALLY 985
ENRPLMRPVSEMALLY
Sbjct: 910 ENRPLMRPVSEMALLY 925
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 845 bits (2184), Expect = 0.0
Identities = 450/959 (46%), Positives = 611/959 (63%), Gaps = 11/959 (1%)
Query: 5 AFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLD 64
A+LSGGRG+D + +ITFP+ F IP++ V+TYLTSI + F +++DRR D
Sbjct: 108 AYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRD 167
Query: 65 TWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSV 124
W+S+K S+ +I+ASFP NL LVLVLRPT F QRT +DI F F+++DF +K+PV+MLSSV
Sbjct: 168 KWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSV 227
Query: 125 SDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETEL 184
DL YID QLT +LGGTL YCHS W+ R AIE+FAL VK+ AQMLQSFGTELAETEL
Sbjct: 228 PDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETEL 287
Query: 185 PDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISG 244
P+D+ S +L E+ K D+ KEG +L +L EG+ S ++
Sbjct: 288 PNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPS---VNQDQLD 344
Query: 245 DWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAEL 304
+ T+ +LL Q+++ E AFD FW KHQ K+EQ LQL FEQ F+++ ++ + A
Sbjct: 345 NQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATF 404
Query: 305 ADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELR 364
D+ ++A V+ ++ L + +E S + +A+ + L G +L N HYA+D I +C ELR
Sbjct: 405 TDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELR 464
Query: 365 YLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQ 424
+L D EI +R LS++ ++H+ L+ + + CDEG LLA+Q +DK QS++ A+ ALQ
Sbjct: 465 HLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQ 524
Query: 425 DIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNL 484
+IE FLE E + E++ IL+ +L ++ + K ++ +F +QA + L
Sbjct: 525 EIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKL 584
Query: 485 ADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS---G 541
A + RP+Q V P PE L S P ++G + L+ + + S G
Sbjct: 585 AARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQG 644
Query: 542 PSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNK 601
S+ + SL +L+ HV++EL+ TER YV EL VL GY AEMDNP M L+ L NK
Sbjct: 645 RGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNK 704
Query: 602 KDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI 661
KD+LFGNM EIY FHN IFL LEN PE VG CFLER +DFQ+Y KYCQNKPRSE++
Sbjct: 705 KDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESL 764
Query: 662 WRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKA 721
WR+ S+C FFQECQRKL H+L LDSYLLKPVQRITKYQLLLKE+LKYS++CEG+ L++A
Sbjct: 765 WRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEA 824
Query: 722 LDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKP 781
L ++L +LK+VNDSMH IAI GY GNL +LGK++MQG FSVW HK+G TK+K+LARFKP
Sbjct: 825 LSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKP 884
Query: 782 MQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG 841
MQRHLFL+EKA++FCK+R E+GEG ++ PSYS+K M VGITE VKGD +KFEIWY
Sbjct: 885 MQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 944
Query: 842 EKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDE 901
+EEVYIVQA ++K W+ EIR +L Q L ++ Q L + + +
Sbjct: 945 AREEVYIVQAPTPEIKAAWVNEIRKVLTSQ--LQACREASQHRALEQSQSLPLPAPTSTS 1002
Query: 902 KQQG---AFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSS 957
+G EE + + S V A + E W++ S S E E+ WSS
Sbjct: 1003 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSS 1061
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 845 bits (2184), Expect = 0.0
Identities = 450/959 (46%), Positives = 611/959 (63%), Gaps = 11/959 (1%)
Query: 5 AFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLD 64
A+LSGGRG+D + +ITFP+ F IP++ V+TYLTSI + F +++DRR D
Sbjct: 55 AYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRD 114
Query: 65 TWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSV 124
W+S+K S+ +I+ASFP NL LVLVLRPT F QRT +DI F F+++DF +K+PV+MLSSV
Sbjct: 115 KWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSV 174
Query: 125 SDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETEL 184
DL YID QLT +LGGTL YCHS W+ R AIE+FAL VK+ AQMLQSFGTELAETEL
Sbjct: 175 PDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETEL 234
Query: 185 PDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISG 244
P+D+ S +L E+ K D+ KEG +L +L EG+ S ++
Sbjct: 235 PNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPS---VNQDQLD 291
Query: 245 DWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAEL 304
+ T+ +LL Q+++ E AFD FW KHQ K+EQ LQL FEQ F+++ ++ + A
Sbjct: 292 NQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATF 351
Query: 305 ADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELR 364
D+ ++A V+ ++ L + +E S + +A+ + L G +L N HYA+D I +C ELR
Sbjct: 352 TDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELR 411
Query: 365 YLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQ 424
+L D EI +R LS++ ++H+ L+ + + CDEG LLA+Q +DK QS++ A+ ALQ
Sbjct: 412 HLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQ 471
Query: 425 DIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNL 484
+IE FLE E + E++ IL+ +L ++ + K ++ +F +QA + L
Sbjct: 472 EIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKL 531
Query: 485 ADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS---G 541
A + RP+Q V P PE L S P ++G + L+ + + S G
Sbjct: 532 AARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQG 591
Query: 542 PSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNK 601
S+ + SL +L+ HV++EL+ TER YV EL VL GY AEMDNP M L+ L NK
Sbjct: 592 RGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNK 651
Query: 602 KDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI 661
KD+LFGNM EIY FHN IFL LEN PE VG CFLER +DFQ+Y KYCQNKPRSE++
Sbjct: 652 KDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESL 711
Query: 662 WRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKA 721
WR+ S+C FFQECQRKL H+L LDSYLLKPVQRITKYQLLLKE+LKYS++CEG+ L++A
Sbjct: 712 WRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEA 771
Query: 722 LDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKP 781
L ++L +LK+VNDSMH IAI GY GNL +LGK++MQG FSVW HK+G TK+K+LARFKP
Sbjct: 772 LSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKP 831
Query: 782 MQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG 841
MQRHLFL+EKA++FCK+R E+GEG ++ PSYS+K M VGITE VKGD +KFEIWY
Sbjct: 832 MQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYN 891
Query: 842 EKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDE 901
+EEVYIVQA ++K W+ EIR +L Q L ++ Q L + + +
Sbjct: 892 AREEVYIVQAPTPEIKAAWVNEIRKVLTSQ--LQACREASQHRALEQSQSLPLPAPTSTS 949
Query: 902 KQQG---AFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSS 957
+G EE + + S V A + E W++ S S E E+ WSS
Sbjct: 950 PSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSS 1008
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 631 bits (1627), Expect = e-180
Identities = 358/934 (38%), Positives = 541/934 (57%), Gaps = 52/934 (5%)
Query: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
+ A LSGGRG+D A IITFPE F+ IP+E V+TYLTSI + F +++DR
Sbjct: 47 RQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDR 106
Query: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
R D WSS+K SL +I+ +FPGNL L+ +LRP+ F+QRTFTDIG + + +F K+P++M+
Sbjct: 107 RRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMV 166
Query: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
+SVSDL YID QLT ELGGTL+Y H +W+ R AIENFALT+K AQMLQ+FG+ LA
Sbjct: 167 NSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLAT 226
Query: 182 TELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQ 241
ELP + S E++L + L++++ + K+G LL+ ++ P T+ +S+L ++
Sbjct: 227 AELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATK-CPNSKLNLNQ- 284
Query: 242 ISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQ 301
+ T+ +LL Q+ + E AF FW +H LK+ Q LQL FE DF + ++ LL +Q
Sbjct: 285 -LENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQ 343
Query: 302 AELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCN 361
AE + ++ V+Q +K+ + L+E SQE L KAQ + L G +L +HHYA D I RC
Sbjct: 344 AEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCV 403
Query: 362 ELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQK 421
ELR+L D +N K K L ++ + H+ L + Q C+ G LLA+Q +DK QS+E
Sbjct: 404 ELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDI 463
Query: 422 ALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGF 481
AL DI FL + P+ EF+++L+ + K + + + +L++++ IF +Q
Sbjct: 464 ALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSL 523
Query: 482 RNLADKHVRPIQFVVPTPEN---------------------LVTSGTPFFSSKQGKKTWR 520
LA K RP+Q V P PE+ L TS P+ ++ +
Sbjct: 524 MKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKE 583
Query: 521 QNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVL--KNHVLNELIQTERVYVRELYTVL 578
+++ +++ + G + L+ L L + ++ +L++TE +Y++E+ +++
Sbjct: 584 DDETKFEVKSEEIFESHHERG-NPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSII 642
Query: 579 LGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCF 638
GY MD + L+P +L+N KD LFGN+ E+YEFHN FL LE CA PE + CF
Sbjct: 643 DGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCF 702
Query: 639 LERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKY 698
L+RK+D Q+Y KY +N PR+ IW++ +CA+F CQR+L H L L YL P QR+ KY
Sbjct: 703 LKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKY 762
Query: 699 QLLLKELL-----------------------KYSKDCEGSALLKKALDAMLDLLKSVNDS 735
Q+LLK LL K +KD S L++AL + DL+KS +
Sbjct: 763 QMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELA 822
Query: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
+ A+ ++ +LGK+++ G FSVW H K KMKDL RFKP QR ++L+E+ IVF
Sbjct: 823 VDLAAVTECPDDIGKLGKLLLHGPFSVWTIH-KDRYKMKDLIRFKPSQRQIYLFERGIVF 881
Query: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVD 855
CK R+E G+ P YSFK K+ + I + +G +RKFEI E YI+QA++ +
Sbjct: 882 CKIRMEPGD-QGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKE 940
Query: 856 VKMTWLKEIRNILLKQQELLTVKKRKQQDQLTER 889
++ W EI +L++QQ + + Q + T +
Sbjct: 941 IRDCWFSEISKLLMEQQNNIKDQGNPQFEMSTSK 974
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 229 bits (585), Expect = 7e-60
Identities = 149/418 (35%), Positives = 225/418 (53%), Gaps = 37/418 (8%)
Query: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
K ++ EL+QTE+ YVR+L+ L Y EM + + +PP + NK+ I+FGN+ EIY+F
Sbjct: 1282 KEFIMAELLQTEKAYVRDLHECLETYLWEMTSG--VEEIPPGILNKEHIIFGNIQEIYDF 1339
Query: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ FF E Q
Sbjct: 1340 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQ 1398
Query: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 735
++ + SYL+KPVQRITKYQLLLKELL + EG LK L+ ML + K ND+
Sbjct: 1399 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDA 1456
Query: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
MH + G+ NL+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVW--------DPKSLIR-KGRERHLFLFEISLVF 1507
Query: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG---EKEEVYIVQAS 852
K + S + Y +K+ E+G+TE+V+GD KF +W G + +++AS
Sbjct: 1508 SKEI----KDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
Query: 853 NVDVKMTWLKEIRNILLK---------QQELLTVKKRKQQDQLTERDKFQISLQQNDEKQ 903
N++ K W+K IR ++ + ++ L K +Q ++RD + Q D
Sbjct: 1564 NIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGDGSS 1623
Query: 904 QGAFISTEETELEHTSTVVEV---CEAIASVQ----AEANTVWTEASQSAEISEEPAE 954
Q IS ++T ++ CE +Q ++ + + Q+ E+ E P+E
Sbjct: 1624 QPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSE 1681
Score = 192 bits (488), Expect = 1e-48
Identities = 113/335 (33%), Positives = 186/335 (55%), Gaps = 25/335 (7%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VLNEL+QTE+ YV++L V+ G+ ++ + P +R K I+FGN+ +IY++H D
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGV----PEDMRGKDKIVFGNIHQIYDWHKD 1988
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL+ LE C +R+ F++ + +Y YCQNKPRSE I +Y A+F+E ++++
Sbjct: 1989 FFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYD--AYFEEVKQEI 2046
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSK----DCEGSALLKKALDAMLDLLKSVND 734
RL L +L+KP+QRITKYQLLLK+ L+YS+ +C ++KA++ M + K ND
Sbjct: 2047 NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSD---IEKAVELMCLVPKRCND 2103
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
M+ + G+ G L GK++ Q F V ++ + + +R +FL+E+ ++
Sbjct: 2104 MMNLGRLQGFEGTLTAQGKLLQQDTFYV--------IELDAGMQSRTKERRVFLFEQIVI 2155
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNV 854
F E P Y FK KM+ + + E V D KF + E E ++QA+N
Sbjct: 2156 FS----ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANA 2211
Query: 855 DVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTER 889
D++ W+++I +L Q++ L + + Q ER
Sbjct: 2212 DIQQAWVQDINQVLETQRDFLNALQSPIEYQRKER 2246
Score = 134 bits (337), Expect = 4e-31
Identities = 104/372 (27%), Positives = 169/372 (45%), Gaps = 26/372 (6%)
Query: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
+ +AF+SGGR K I+TFP N I +E + K++TYL S+ ++ FT+I+D
Sbjct: 41 EKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDM 100
Query: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
R W +K L+ + +FP +H+ L+++P +F Q+ T+ F F+ + +V
Sbjct: 101 RGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSSKFIFETSMV-- 154
Query: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
SV L +D QLT E G+L Y H EWI R ++E F + + L+ LA
Sbjct: 155 -SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLAR 213
Query: 182 TELPDDIPSIEEILAIRAE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
E P D+ ++ + + +LK + + +EG+ LL + D S R C
Sbjct: 214 KEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD---GFSGR-NCIP 269
Query: 241 QISGDWQT----INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEV-- 294
S D+Q+ I LL ++H W +LK++Q QL FEQD +++ +
Sbjct: 270 G-SADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISH 328
Query: 295 --EFLLNQQAELADVTGTIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHY 351
E L E+ G Q ++ N NS ++ +L+ HY
Sbjct: 329 NKELFLQSHTEI----GVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHY 384
Query: 352 ALDLICQRCNEL 363
A I Q +L
Sbjct: 385 ASQQIKQISTQL 396
Score = 51.2 bits (121), Expect = 5e-06
Identities = 51/242 (21%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 153 IFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAV 212
+F E F V +M G LP ++ +E + Y + T V
Sbjct: 419 VFHQKAEQFLSGVDAWCKMCSEGG-------LPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
Query: 213 TKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM---ETAFDGFWEK 269
+++GK LL L+ P + G S L S + ++++L VH++ + + W+
Sbjct: 472 SQDGKALLDVLQRPLSPGN-SESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
Query: 270 HQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQVKQKIKKLENLDE 326
++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ + + K+ ++ +E
Sbjct: 528 RKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
Query: 327 NSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFK 386
+Q + A ++ +LA + I + L V ++ +++ L +
Sbjct: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
Query: 387 MH 388
H
Sbjct: 646 FH 647
Score = 45.1 bits (105), Expect = 3e-04
Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 32/258 (12%)
Query: 160 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 219
+F KE+ ++ E+ E D + +++E++ ++ + V KEG+ L
Sbjct: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
Query: 220 LTNLE-VPDTEG--------AVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 270
+ L P + G AVS+ H S I +L Q+ D + + + +
Sbjct: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPH---SSSISHIESVLQQLDDAQVQMEELFHER 761
Query: 271 QLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTGTIAQVKQKIKKLENLDE 326
++K++ +LQL FEQ ++ E+ E LL Q + T+A+ ++L+ E
Sbjct: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAE-----QRLQRHTE 816
Query: 327 NSQELLSKAQFVILHGHKLAANHHY-------ALDLICQRCNELRYLSDILVNEIKAKRI 379
+ + VI G L H Y ++LIC++ +L L+ + K+
Sbjct: 817 RKLAMNNMTFEVIQQGQDL---HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQH 873
Query: 380 QLS-RTFKMHKLLQQARQ 396
+L + HK L+Q Q
Sbjct: 874 ELELNAEQTHKRLEQCLQ 891
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 226 bits (576), Expect = 8e-59
Identities = 139/354 (39%), Positives = 206/354 (58%), Gaps = 28/354 (7%)
Query: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
K ++ EL+QTE+ YVR+L+ L Y EM + + +PP + NK+ I+FGN+ EIY+F
Sbjct: 1282 KEFIMAELLQTEKAYVRDLHECLETYLWEMTSG--VEEIPPGILNKEHIIFGNIQEIYDF 1339
Query: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ FF E Q
Sbjct: 1340 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAG-TFFDEIQ 1398
Query: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 735
++ + SYL+KPVQRITKYQLLLKELL + EG LK L+ ML + K ND+
Sbjct: 1399 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGELKDGLEVMLSVPKKANDA 1456
Query: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
MH + G+ NL+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 1457 MHVSMLEGFDENLDVQGELILQDAFQVW--------DPKSLIR-KGRERHLFLFEISLVF 1507
Query: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYG---EKEEVYIVQAS 852
K + S + Y +K+ E+G+TE+V+GD KF +W G + +++AS
Sbjct: 1508 SKEI----KDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKAS 1563
Query: 853 NVDVKMTWLKEIRNILLKQQELLTVK-KRKQQDQLTERDKFQISLQQNDEKQQG 905
N++ K W+K IR ++ Q+ ++ +K K+ QL + + Q+N+ K+ G
Sbjct: 1564 NIETKQEWIKNIREVI--QERIIHLKGALKEPLQLPKTP----AKQRNNSKRDG 1611
Score = 134 bits (337), Expect = 4e-31
Identities = 104/372 (27%), Positives = 169/372 (45%), Gaps = 26/372 (6%)
Query: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
+ +AF+SGGR K I+TFP N I +E + K++TYL S+ ++ FT+I+D
Sbjct: 41 EKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDM 100
Query: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
R W +K L+ + +FP +H+ L+++P +F Q+ T+ F F+ + +V
Sbjct: 101 RGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTN----FGSSKFIFETSMV-- 154
Query: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
SV L +D QLT E G+L Y H EWI R ++E F + + L+ LA
Sbjct: 155 -SVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLAR 213
Query: 182 TELPDDIPSIEEILAIRAE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
E P D+ ++ + + +LK + + +EG+ LL + D S R C
Sbjct: 214 KEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD---GFSGR-NCIP 269
Query: 241 QISGDWQT----INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEV-- 294
S D+Q+ I LL ++H W +LK++Q QL FEQD +++ +
Sbjct: 270 G-SADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISH 328
Query: 295 --EFLLNQQAELADVTGTIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHY 351
E L E+ G Q ++ N NS ++ +L+ HY
Sbjct: 329 NKELFLQSHTEI----GVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHY 384
Query: 352 ALDLICQRCNEL 363
A I Q +L
Sbjct: 385 ASQQIKQISTQL 396
Score = 51.2 bits (121), Expect = 5e-06
Identities = 51/242 (21%), Positives = 105/242 (43%), Gaps = 19/242 (7%)
Query: 153 IFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAV 212
+F E F V +M G LP ++ +E + Y + T V
Sbjct: 419 VFHQKAEQFLSGVDAWCKMCSEGG-------LPSEMQDLELAIHHHQTLYEQVTQAYTEV 471
Query: 213 TKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM---ETAFDGFWEK 269
+++GK LL L+ P + G S L S + ++++L VH++ + + W+
Sbjct: 472 SQDGKALLDVLQRPLSPGN-SESLTATANYS---KAVHQVLDVVHEVLHHQRRLESIWQH 527
Query: 270 HQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQVKQKIKKLENLDE 326
++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ + + K+ ++ +E
Sbjct: 528 RKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHRARALQKRHDDFEE 585
Query: 327 NSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFK 386
+Q + A ++ +LA + I + L V ++ +++ L +
Sbjct: 586 VAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVS 645
Query: 387 MH 388
H
Sbjct: 646 FH 647
Score = 45.1 bits (105), Expect = 3e-04
Identities = 58/258 (22%), Positives = 109/258 (42%), Gaps = 32/258 (12%)
Query: 160 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 219
+F KE+ ++ E+ E D + +++E++ ++ + V KEG+ L
Sbjct: 645 SFHTHTKELWTWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDL 704
Query: 220 LTNLE-VPDTEG--------AVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKH 270
+ L P + G AVS+ H S I +L Q+ D + + + +
Sbjct: 705 IQQLRSAPPSLGEPSEARDSAVSNNKTPH---SSSISHIESVLQQLDDAQVQMEELFHER 761
Query: 271 QLKMEQYLQLWKFEQDFQQLVTEV----EFLLNQQAELADVTGTIAQVKQKIKKLENLDE 326
++K++ +LQL FEQ ++ E+ E LL Q + T+A+ ++L+ E
Sbjct: 762 KIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAE-----QRLQRHTE 816
Query: 327 NSQELLSKAQFVILHGHKLAANHHY-------ALDLICQRCNELRYLSDILVNEIKAKRI 379
+ + VI G L H Y ++LIC++ +L L+ + K+
Sbjct: 817 RKLAMNNMTFEVIQQGQDL---HQYITEVQASGIELICEKDIDLAAQVQELLEFLHEKQH 873
Query: 380 QLS-RTFKMHKLLQQARQ 396
+L + HK L+Q Q
Sbjct: 874 ELELNAEQTHKRLEQCLQ 891
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 218 bits (554), Expect = 3e-56
Identities = 129/316 (40%), Positives = 185/316 (58%), Gaps = 21/316 (6%)
Query: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
K ++ ELIQTE+ YVR+L + Y EM + + +PP + NK+ I+FGNM EIYEF
Sbjct: 1293 KEFIMAELIQTEKAYVRDLRECMDTYLWEMTSG--VEEIPPGIVNKELIIFGNMQEIYEF 1350
Query: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
HN+IFL LE PE VG CF+ D FQMY YC+NKP S + +++ ++F E Q
Sbjct: 1351 HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-SYFDEIQ 1409
Query: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDS 735
++ + SYL+KPVQRITKYQLLLKELL + EG +K L+ ML + K ND+
Sbjct: 1410 QRHGLANSISSYLIKPVQRITKYQLLLKELLTCCE--EGKGEIKDGLEVMLSVPKRANDA 1467
Query: 736 MHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVF 795
MH + G+ N+ G++I+Q F VW K L R K +RHLFL+E ++VF
Sbjct: 1468 MHLSMLEGFDENIESQGELILQESFQVW--------DPKTLIR-KGRERHLFLFEMSLVF 1518
Query: 796 CKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGE---KEEVYIVQAS 852
K +S S Y +K E+G+TE+V+GD KF +W G + +++AS
Sbjct: 1519 SKEVKDSSGRS----KYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKAS 1574
Query: 853 NVDVKMTWLKEIRNIL 868
+++ K W+K IR ++
Sbjct: 1575 SIENKQDWIKHIREVI 1590
Score = 194 bits (494), Expect = 3e-49
Identities = 121/341 (35%), Positives = 193/341 (56%), Gaps = 19/341 (5%)
Query: 539 SSGPSSSLDNGNSLDVLKNH-VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPL 597
SS P ++ S + + H VL EL++TER YVR+L V+ GY A M D +P
Sbjct: 1952 SSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE----DGVPDD 2007
Query: 598 LRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPR 657
++ K I+FGN+ +IY++H D FL LE C PE++G F++ + MY YCQNKP+
Sbjct: 2008 MKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPK 2067
Query: 658 SETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCE-GSA 716
SE I +Y + FF++ +++L HRL+L L+KPVQRI KYQLLLK+ LKYSK ++
Sbjct: 2068 SEHIVSEYID-TFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTS 2126
Query: 717 LLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDL 776
L++A++ M + + ND M+ + G+ G + GK+++Q F V T
Sbjct: 2127 ELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLV--------TDQDAG 2178
Query: 777 ARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKF 836
+ +R +FL+E+ ++F ++ +G P + FK+ K+ + + E V+ D KF
Sbjct: 2179 LLPRCRERRIFLFEQIVIF-SEPLDKKKGFS-MPGFLFKNSIKVSCLCLEENVENDPCKF 2236
Query: 837 EIW--YGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELL 875
+ G+ E +I+ +S+ V+ TW+ EI IL Q+ L
Sbjct: 2237 ALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFL 2277
Score = 134 bits (337), Expect = 4e-31
Identities = 116/464 (25%), Positives = 206/464 (44%), Gaps = 27/464 (5%)
Query: 2 QDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILDR 61
+ +A+LSGGR K I+TFP N I +E + ++++YL I + FT+I+D
Sbjct: 71 EKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDM 130
Query: 62 RLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVML 121
R W S+K L+ + SFP +H+ L+++P +F Q+ T+ F F + +V
Sbjct: 131 RGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTN----FGSSKFEFETNMV-- 184
Query: 122 SSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAE 181
S+ L +D QLTPE G L+Y H EWI R A E++ M L+ LA+
Sbjct: 185 -SLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAK 243
Query: 182 TELPDDIPSIEEILAIRAE-RYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR 240
ELP D+ ++ ++ + ++K I + EG+ LL ++ ++ +S +
Sbjct: 244 KELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSG-SGNA 302
Query: 241 QISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQD----FQQLVTEVEF 296
+ ++ +L ++H W +LK++Q QL FEQD F +
Sbjct: 303 DLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGL 362
Query: 297 LLNQQAELADVTGTIAQVKQKIKKLEN-LDENSQELLSKAQFVILHGHKLAANHHYALDL 355
LN E+ GT +++ N N + ++ ++L + HYA
Sbjct: 363 FLNSYTEI----GTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQ 418
Query: 356 ICQRCNEL--RYLSDILVNEIKAKRIQLSRTF--KMHKLLQQARQCCDE-GECLLANQEI 410
I Q ++L + + + ++ + +S F K K + C GE L ++
Sbjct: 419 IRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSE-- 476
Query: 411 DKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSP 454
Q EDA Q I + +A ++ + ++L + L+P
Sbjct: 477 --LQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTP 518
Score = 58.5 bits (140), Expect = 3e-08
Identities = 66/326 (20%), Positives = 140/326 (42%), Gaps = 34/326 (10%)
Query: 150 EWIIFRNAIEN----------FALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRA 199
EW F A++ F ++ + S+ E +LP ++ +E+ +
Sbjct: 429 EWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQ 488
Query: 200 ERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDM 259
Y + + V+++GK LL L+ P T G+ S L S + ++ +L +H++
Sbjct: 489 GIYEHITLAYSEVSQDGKSLLDKLQRPLTPGS-SDSLTASANYS---KAVHHVLDVIHEV 544
Query: 260 ---ETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTG---TIAQ 313
+ + W+ ++++ Q LQL F+QD QQ++ +E + +A L+ TG ++ +
Sbjct: 545 LHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIE--NHGEAFLSKHTGVGKSLHR 602
Query: 314 VKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNE 373
+ K+ E+ +E +Q + A ++ +LA + I Q ++L V
Sbjct: 603 ARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFVRR 662
Query: 374 IKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMA 433
++ ++I L + H +++ +E L + +D + + +E ++
Sbjct: 663 VEQRKILLDMSVSFHTHVKELWTWLEE----LQKELLDDVYA--------ESVEAVQDLI 710
Query: 434 LPFINYEPETLQYEFDVILSPELKVQ 459
F + TLQ +VI E +Q
Sbjct: 711 KRFGQQQQTTLQVTVNVIKEGEDLIQ 736
Score = 50.8 bits (120), Expect = 6e-06
Identities = 48/244 (19%), Positives = 117/244 (47%), Gaps = 17/244 (6%)
Query: 160 NFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKIL 219
+F VKE+ L+ EL + + + ++++++ ++ V KEG+ L
Sbjct: 675 SFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTTLQVTVNVIKEGEDL 734
Query: 220 LTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQ 279
+ L + A+SS H +T+ L Q+ + ++ + +++ ++K+E +LQ
Sbjct: 735 IQQLR----DSAISSNKTPHNSSINHIETV---LQQLDEAQSQMEELFQERKIKLELFLQ 787
Query: 280 LWKFEQDFQQLVTEVEFL---LNQQA---ELADVTGTIAQVKQKIKKLENLDENSQELLS 333
L FE+D +++++E L+QQ + D+T +++ K ++ + +++
Sbjct: 788 LRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIH 847
Query: 334 KAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMH-KLLQ 392
+ Q ++ + +++ A+ ++L+C R ++ L+ + K+ +L + H K L+
Sbjct: 848 QGQDLLQYVNEVQAS---GVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLE 904
Query: 393 QARQ 396
Q Q
Sbjct: 905 QCVQ 908
Score = 37.4 bits (85), Expect = 0.070
Identities = 42/194 (21%), Positives = 83/194 (42%), Gaps = 20/194 (10%)
Query: 167 EMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVP 226
E++Q + F TE D+ E+ L A++ + N V +G+ LL +
Sbjct: 808 ELSQQMNDFDTE--------DLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEV 859
Query: 227 DTEGAVSSRLECHRQISGDWQT-INKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQ 285
G L C R + D T + LL +H+ + D E+H+ +EQ +QL +
Sbjct: 860 QASGV---ELLCDRDV--DMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQA 914
Query: 286 DFQQL---VTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHG 342
+ +Q+ + E +LN A Q++++ ++ ++ E + + + Q
Sbjct: 915 EVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQ---QKA 971
Query: 343 HKLAANHHYALDLI 356
+ +HY +D+I
Sbjct: 972 EAMLQANHYDMDMI 985
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 192 bits (488), Expect = 1e-48
Identities = 113/335 (33%), Positives = 186/335 (55%), Gaps = 25/335 (7%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VLNEL+QTE+ YV++L V+ G+ ++ + P +R K I+FGN+ +IY++H D
Sbjct: 236 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKGV----PEDMRGKDKIVFGNIHQIYDWHKD 291
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL+ LE C +R+ F++ + +Y YCQNKPRSE I +Y A+F+E ++++
Sbjct: 292 FFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYD--AYFEEVKQEI 349
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSK----DCEGSALLKKALDAMLDLLKSVND 734
RL L +L+KP+QRITKYQLLLK+ L+YS+ +C ++KA++ M + K ND
Sbjct: 350 NQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSD---IEKAVELMCLVPKRCND 406
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
M+ + G+ G L GK++ Q F V ++ + + +R +FL+E+ ++
Sbjct: 407 MMNLGRLQGFEGTLTAQGKLLQQDTFYV--------IELDAGMQSRTKERRVFLFEQIVI 458
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNV 854
F E P Y FK KM+ + + E V D KF + E E ++QA+N
Sbjct: 459 FS----ELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANA 514
Query: 855 DVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTER 889
D++ W+++I +L Q++ L + + Q ER
Sbjct: 515 DIQQAWVQDINQVLETQRDFLNALQSPIEYQRKER 549
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
sapiens]
Length = 580
Score = 184 bits (466), Expect = 5e-46
Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)
Query: 532 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 591
P +E S P S + +VL+EL++TE++YV +L ++ GY A M +
Sbjct: 137 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 195
Query: 592 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 651
P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y
Sbjct: 196 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 252
Query: 652 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 710
CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 253 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 311
Query: 711 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 770
+A L++A++ M + K ND M + G+ G L GK++ Q F W+ +
Sbjct: 312 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 369
Query: 771 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 830
+ R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++
Sbjct: 370 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 424
Query: 831 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 875
GD +F + E + Y++QA++ + W+K + IL Q++ L
Sbjct: 425 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 472
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
sapiens]
Length = 619
Score = 184 bits (466), Expect = 5e-46
Identities = 112/348 (32%), Positives = 190/348 (54%), Gaps = 16/348 (4%)
Query: 532 PDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMF 591
P +E S P S + +VL+EL++TE++YV +L ++ GY A M +
Sbjct: 176 PPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGV- 234
Query: 592 DLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKY 651
P LR + I+FGN+ +IYE+H D FL L+ C P+ + F++ + MY Y
Sbjct: 235 ---PESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVY 291
Query: 652 CQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-YSK 710
CQNKP+SE + ++ + ++F+E +++L HRL+L+ L+KPVQRI KYQLLLK+ LK Y++
Sbjct: 292 CQNKPKSEHVVSEFGD-SYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNR 350
Query: 711 DCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGA 770
+A L++A++ M + K ND M + G+ G L GK++ Q F W+ +
Sbjct: 351 AGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTF--WVTEPEAG 408
Query: 771 TKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVK 830
+ R +R +FL+E+ I+F + G P Y +K+ K+ +G+ ++
Sbjct: 409 GLLSSRGR----ERRVFLFEQIIIF-SEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQ 463
Query: 831 GDNRKFEIWYGEKE---EVYIVQASNVDVKMTWLKEIRNILLKQQELL 875
GD +F + E + Y++QA++ + W+K + IL Q++ L
Sbjct: 464 GDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFL 511
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 182 bits (463), Expect = 1e-45
Identities = 118/321 (36%), Positives = 176/321 (54%), Gaps = 29/321 (9%)
Query: 558 HVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHN 617
H++ E+I TER Y+R L V+ Y EM+ ++ P LR K ++FGN+ ++++FH
Sbjct: 808 HIMAEMIATEREYIRCLGYVIDNYFPEMERMDL----PQGLRGKHHVIFGNLEKLHDFHQ 863
Query: 618 DIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRK 677
FL LE C H P VG FL ++ F MY Y +NKP+S+ + + AFF++ QR+
Sbjct: 864 QHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGN-AFFKDKQRE 922
Query: 678 LKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKD--CEGSAL--LKKALDAMLDLLKSVN 733
L ++ L SYLL+PVQR+ KY LLL++LLK + +G L L+ A + L+ N
Sbjct: 923 LGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGN 982
Query: 734 DSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAI 793
D + AI G NL E G++ + F V G KK RH+FL+E I
Sbjct: 983 DLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKK-------------YLRHVFLFEDLI 1029
Query: 794 VFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK---EEVYIVQ 850
+F K + EGS + Y +K +K E+G+TE V +FEIW+ + ++ YI+Q
Sbjct: 1030 LFSK--TQKVEGS--HDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQ 1085
Query: 851 ASNVDVKMTWLKEIRNILLKQ 871
AS+ +VK W I IL +Q
Sbjct: 1086 ASSAEVKSAWTDVIGRILWRQ 1106
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/192 (23%), Positives = 84/192 (43%), Gaps = 14/192 (7%)
Query: 35 IAKVLTYLTSIARQNGSDSRFTIILD-RRLDTWSSLKISLQKISASFPGNLHLVLVLRPT 93
+ ++L Y SI R+ D +++D RR ++ +L + + +H +L+L
Sbjct: 236 LTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDK 295
Query: 94 SFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWII 153
R +D +++ VV SS+ + ++D QLT +L G+ Y H +WI
Sbjct: 296 ESAFRP---------DKDAIIQCEVV--SSLKAVHKFVDSCQLTADLDGSFPYSHGDWIC 344
Query: 154 FRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKND--ITA 211
FR +E+FA +E LQ+ L P + E++ L+ D + +
Sbjct: 345 FRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVS 404
Query: 212 VTKEGKILLTNL 223
+ EG +L L
Sbjct: 405 LRLEGGTVLARL 416
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 176 bits (447), Expect = 7e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 655 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 710
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 711 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 769
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 770 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 826
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 827 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 873
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 874 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 929
Query: 853 NVDVKMTWLKEIRNILLKQ 871
++ +K W +I ++L +Q
Sbjct: 930 SLAIKQAWTADISHLLWRQ 948
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 142 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 200
Query: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 201 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 245
Query: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
H W+ FR +E + +LQ
Sbjct: 246 HQAWLDFRRRLEALLQNCQAACALLQ 271
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 176 bits (447), Expect = 7e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 736 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 791
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 792 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 850
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 851 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 954
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 955 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 1010
Query: 853 NVDVKMTWLKEIRNILLKQ 871
++ +K W +I ++L +Q
Sbjct: 1011 SLAIKQAWTADISHLLWRQ 1029
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 223 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 281
Query: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 282 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 326
Query: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
H W+ FR +E + +LQ
Sbjct: 327 HQAWLDFRRRLEALLQNCQAACALLQ 352
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 176 bits (447), Expect = 7e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 736 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 791
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 792 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 850
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 851 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 954
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 955 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 1010
Query: 853 NVDVKMTWLKEIRNILLKQ 871
++ +K W +I ++L +Q
Sbjct: 1011 SLAIKQAWTADISHLLWRQ 1029
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 223 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 281
Query: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 282 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 326
Query: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
H W+ FR +E + +LQ
Sbjct: 327 HQAWLDFRRRLEALLQNCQAACALLQ 352
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 176 bits (447), Expect = 7e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 736 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 791
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 792 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 850
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 851 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 954
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 955 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 1010
Query: 853 NVDVKMTWLKEIRNILLKQ 871
++ +K W +I ++L +Q
Sbjct: 1011 SLAIKQAWTADISHLLWRQ 1029
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 223 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 281
Query: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 282 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 326
Query: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
H W+ FR +E + +LQ
Sbjct: 327 HQAWLDFRRRLEALLQNCQAACALLQ 352
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 176 bits (447), Expect = 7e-44
Identities = 111/319 (34%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL E++ TER YVR L + Y E+D P++ P LR ++ LFGN+ ++ +FH
Sbjct: 736 VLAEMVATEREYVRALEYTMENYFPELDRPDV----PQGLRGQRAHLFGNLEKLRDFHCH 791
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKL 678
FL LE C P RV FL + F MYA Y +NKPRS+ + Y FF++ Q+ L
Sbjct: 792 FFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH-TFFKDKQQAL 850
Query: 679 KHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGS----ALLKKALDAMLDLLKSVND 734
L L SYLLKP+QR+ KY LLL+EL ++ C G + L++A + L+ ND
Sbjct: 851 GDHLDLASYLLKPIQRMGKYALLLQEL---ARACGGPTQELSALREAQSLVHFQLRHGND 907
Query: 735 SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
+ AI G NL E G+++ Q F V G K R +FL+E+ ++
Sbjct: 908 LLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSV-------------RRIFLFEELLL 954
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKE--EVYIVQAS 852
F K R G ++++K +KM ++G+TE N +FEIW+ ++ + +++QAS
Sbjct: 955 FSKPR----HGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQAS 1010
Query: 853 NVDVKMTWLKEIRNILLKQ 871
++ +K W +I ++L +Q
Sbjct: 1011 SLAIKQAWTADISHLLWRQ 1029
Score = 50.4 bits (119), Expect = 8e-06
Identities = 43/146 (29%), Positives = 66/146 (45%), Gaps = 17/146 (11%)
Query: 29 CIPEEVIAKVLTYLTSIARQNGSDSRFTIILDRRLDTWSSLKIS-LQKISASFPGNLHLV 87
C +E+I ++L YL SI R T+++D R+ SS S L ++ + PG ++ V
Sbjct: 223 CSSQELI-RLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQV 281
Query: 88 LVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYC 147
L++ T ++ L + L S S LLT+I L LGG L YC
Sbjct: 282 LLVGSTLL--------------KEVPSGLQLEQLPSQS-LLTHIPTAGLPTSLGGGLPYC 326
Query: 148 HSEWIIFRNAIENFALTVKEMAQMLQ 173
H W+ FR +E + +LQ
Sbjct: 327 HQAWLDFRRRLEALLQNCQAACALLQ 352
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 139 bits (349), Expect = 2e-32
Identities = 109/401 (27%), Positives = 193/401 (48%), Gaps = 58/401 (14%)
Query: 508 PFFSSKQGKKTWRQNQSNLK--IEVVPDCQEKRSSG--PSSSLDNGNSLDVLK-NHVLNE 562
PF SS+ + Q N E P Q + S P + D+ S +L + V+ E
Sbjct: 61 PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE 120
Query: 563 LIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLS 622
+++TER YV++L +++ Y + + PL ++ LFGN+ +IY F++++ L
Sbjct: 121 ILETERTYVQDLKSIVEDYLDCIRDQTKL----PLGTEERSALFGNIQDIYHFNSEL-LQ 175
Query: 623 SLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECA-------FFQECQ 675
LENC + P + CF+ + ++F +Y +YC N PRS + +EC FF+E Q
Sbjct: 176 DLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAV---LTECMRNKILAKFFRERQ 232
Query: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALDAMLDLLKSVND 734
LKH L L SYLLKPVQRI KY LLL E+ + KD EG ++ A+D M + +ND
Sbjct: 233 ETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIND 292
Query: 735 ------------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPM 782
+ + N +L G+++++G F + + K+
Sbjct: 293 MKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI--------QRAKN------- 337
Query: 783 QRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGE 842
+R LFL++K ++ K+R + ++++K + + E + + F +++ +
Sbjct: 338 ERTLFLFDKLLLITKKRDD---------TFTYKAHILCGNLMLVEVIPKEPLSFSVFHYK 388
Query: 843 KEEV-YIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQ 882
++ + VQA + K W+ ++ ++L+ K KQ
Sbjct: 389 NPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQ 429
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 134 bits (338), Expect = 3e-31
Identities = 95/326 (29%), Positives = 169/326 (51%), Gaps = 37/326 (11%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
V+ EL+ +E+ +V EL + + + + E +P + +K ++F N+ +I FH+
Sbjct: 5697 VIQELLSSEQAFVEELQFLQSHH---LQHLERCPHVPIAVAGQKAVIFRNVRDIGRFHSS 5753
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI---------WRKYSECA 669
FL L+ C + V CF++ + F+ Y ++ + ++E++ ++KY+E A
Sbjct: 5754 -FLQELQQC-DTDDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAIQEFYKKYAEEA 5811
Query: 670 FF-----QECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALD 723
Q L+H YL +PV+R+ +YQ LLKEL++ +++ + ALL++A
Sbjct: 5812 LLAGDPSQPPPPPLQH------YLEQPVERVQRYQALLKELIRNKARNRQNCALLEQAYA 5865
Query: 724 AMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQ 783
+ L + + +H + Y G L LG+ I QG F VW G GA +K
Sbjct: 5866 VVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG-APGAR-----MPWKGHN 5919
Query: 784 RHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK 843
RH+FL+ +V CK R +S + SY F++ K+ + + + V+GD+R FE+W +
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDT---VSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQERE 5976
Query: 844 EEV--YIVQASNVDVKMTWLKEIRNI 867
+ V Y++QA +K +W+KEI I
Sbjct: 5977 DSVRKYLLQARTAIIKSSWVKEICGI 6002
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 134 bits (338), Expect = 3e-31
Identities = 95/326 (29%), Positives = 169/326 (51%), Gaps = 37/326 (11%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
V+ EL+ +E+ +V EL + + + + E +P + +K ++F N+ +I FH+
Sbjct: 5697 VIQELLSSEQAFVEELQFLQSHH---LQHLERCPHVPIAVAGQKAVIFRNVRDIGRFHSS 5753
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETI---------WRKYSECA 669
FL L+ C + V CF++ + F+ Y ++ + ++E++ ++KY+E A
Sbjct: 5754 -FLQELQQC-DTDDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAIQEFYKKYAEEA 5811
Query: 670 FF-----QECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALD 723
Q L+H YL +PV+R+ +YQ LLKEL++ +++ + ALL++A
Sbjct: 5812 LLAGDPSQPPPPPLQH------YLEQPVERVQRYQALLKELIRNKARNRQNCALLEQAYA 5865
Query: 724 AMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQ 783
+ L + + +H + Y G L LG+ I QG F VW G GA +K
Sbjct: 5866 VVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVWEG-APGAR-----MPWKGHN 5919
Query: 784 RHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK 843
RH+FL+ +V CK R +S + SY F++ K+ + + + V+GD+R FE+W +
Sbjct: 5920 RHVFLFRNHLVICKPRRDSRTDT---VSYVFRNMMKLSSIDLNDQVEGDDRAFEVWQERE 5976
Query: 844 EEV--YIVQASNVDVKMTWLKEIRNI 867
+ V Y++QA +K +W+KEI I
Sbjct: 5977 DSVRKYLLQARTAIIKSSWVKEICGI 6002
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 113 bits (282), Expect = 1e-24
Identities = 82/260 (31%), Positives = 136/260 (52%), Gaps = 34/260 (13%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
V E+++TER YVR+L +++ Y + + + L + LF N+ +IYEF ++
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSV----EQVGTLFANIEDIYEFSSE 161
Query: 619 IFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYS----ECAFFQEC 674
+ L LEN + A + CF++R +DF +Y YC N P S + R+ S + QE
Sbjct: 162 L-LEDLENSSSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQER 219
Query: 675 QRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSA---LLKKALDAMLDLLKS 731
Q +L+H L L S+LLKPVQRI KY LLL+EL K+ + G+ ++++A+ +M +
Sbjct: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279
Query: 732 VNDSMH-----------QIAINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARF 779
+ND Q + G+ G L+ G+++++G F G G R
Sbjct: 280 INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFR---GGGGGG------PRL 330
Query: 780 KPMQRHLFLYEKAIVFCKRR 799
+ +R LFL+ + ++ KRR
Sbjct: 331 RGGERLLFLFSRMLLVAKRR 350
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 105 bits (261), Expect = 3e-22
Identities = 87/327 (26%), Positives = 149/327 (45%), Gaps = 49/327 (14%)
Query: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
+ +++ELI E+ YV L PE+ P LR + F
Sbjct: 1086 QQRLVSELIACEQDYV-----ATLSEPVPPPGPEL----TPELRGTWAAALSARERLRSF 1136
Query: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
H FL L+ CA P R+G CFL D F +YA+Y +++ + E A +
Sbjct: 1137 HRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLEN-----GLAALSPLSK 1191
Query: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-----YSKDCEGSALLKKALDAMLDLLK 730
++ L L +P++++T+Y LL+ELL+ S +C +AL A + LL+
Sbjct: 1192 GSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSEC-------RALGAAVQLLR 1244
Query: 731 SV----NDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHL 786
D + A+ G +L E G+++ + F+V G KK RH+
Sbjct: 1245 EQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKK-------------CLRHV 1291
Query: 787 FLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK--E 844
FL+E ++F K + G GS+ + +K +K ++G+TE + FE+W+ +
Sbjct: 1292 FLFEHLLLFSKLKGPEG-GSE---MFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR 1347
Query: 845 EVYIVQASNVDVKMTWLKEIRNILLKQ 871
E Y +QA++ ++K+ W I +L +Q
Sbjct: 1348 EAYTLQATSPEIKLKWTSSIAQLLWRQ 1374
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 103 bits (258), Expect = 6e-22
Identities = 103/404 (25%), Positives = 179/404 (44%), Gaps = 80/404 (19%)
Query: 540 SGPSSSLDNG----NSLDVLKNHVLNELIQTERVYVRELYTVLLGY------RAEMDNPE 589
+G S + D G +S D ++ +V+NE++ TER Y++ L + GY RA+M + E
Sbjct: 265 AGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEE 324
Query: 590 MFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCFLERKDDF 645
LR +FGN+ +IY F+ +LE + +G CFLE + DF
Sbjct: 325 Q-------LRT----IFGNIEDIYRCQK-AFVKALEQRFNRERPHLSELGACFLEHQADF 372
Query: 646 QMYAKYCQNKPRS---ETIWRKYSECAFFQECQRKLKHR--LRLDSYLLKPVQRITKYQL 700
Q+Y++YC N P + + K S+ +F E R L+ + LD +LL PVQ+I KY L
Sbjct: 373 QIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
Query: 701 LLKELLKYS-------KDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGK 753
L ELLKY+ KD E AL AM ++ + +N+ ++ N++++ +
Sbjct: 433 QLAELLKYTHPQHRDFKDVEA------ALHAMKNVAQLINERKRRLE------NIDKIAQ 480
Query: 754 MIMQGGFSVWIGHK----------KGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESG 803
Q W G G + K QR FL++ +++CK+ +
Sbjct: 481 --WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLL-- 536
Query: 804 EGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQASNVD 855
R +K MD + + + G +R F + G + +++ +
Sbjct: 537 ----RRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
Query: 856 VKMTWLK----EIRNILLKQQELLTVKKRKQQDQLTERDKFQIS 895
K WLK E + L Q+ ++ + +++ + K Q++
Sbjct: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVT 636
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 103 bits (258), Expect = 6e-22
Identities = 103/404 (25%), Positives = 179/404 (44%), Gaps = 80/404 (19%)
Query: 540 SGPSSSLDNG----NSLDVLKNHVLNELIQTERVYVRELYTVLLGY------RAEMDNPE 589
+G S + D G +S D ++ +V+NE++ TER Y++ L + GY RA+M + E
Sbjct: 265 AGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEE 324
Query: 590 MFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCFLERKDDF 645
LR +FGN+ +IY F+ +LE + +G CFLE + DF
Sbjct: 325 Q-------LRT----IFGNIEDIYRCQK-AFVKALEQRFNRERPHLSELGACFLEHQADF 372
Query: 646 QMYAKYCQNKPRS---ETIWRKYSECAFFQECQRKLKHR--LRLDSYLLKPVQRITKYQL 700
Q+Y++YC N P + + K S+ +F E R L+ + LD +LL PVQ+I KY L
Sbjct: 373 QIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
Query: 701 LLKELLKYS-------KDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGK 753
L ELLKY+ KD E AL AM ++ + +N+ ++ N++++ +
Sbjct: 433 QLAELLKYTHPQHRDFKDVEA------ALHAMKNVAQLINERKRRLE------NIDKIAQ 480
Query: 754 MIMQGGFSVWIGHK----------KGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESG 803
Q W G G + K QR FL++ +++CK+ +
Sbjct: 481 --WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLL-- 536
Query: 804 EGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQASNVD 855
R +K MD + + + G +R F + G + +++ +
Sbjct: 537 ----RRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
Query: 856 VKMTWLK----EIRNILLKQQELLTVKKRKQQDQLTERDKFQIS 895
K WLK E + L Q+ ++ + +++ + K Q++
Sbjct: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVT 636
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 99.4 bits (246), Expect = 1e-20
Identities = 100/383 (26%), Positives = 171/383 (44%), Gaps = 68/383 (17%)
Query: 533 DCQEKRSSGPSSSLDNGNSLD---------VLKNHVLNELIQTERVYVRELYTVLLGY-R 582
+ E SS PS D S ++ +V+ E++ TERVY++ L + GY R
Sbjct: 209 ELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR 268
Query: 583 AEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCF 638
+ MF + + +FGN+ +IY+F FL LE + E +G CF
Sbjct: 269 QCRKHTGMFTVA------QLATIFGNIEDIYKFQRK-FLKDLEKQYNKEEPHLSEIGSCF 321
Query: 639 LERKDDFQMYAKYCQNKPRS----ETIWRKYSECAFFQECQRKLKHRL--RLDSYLLKPV 692
L+ ++ F +Y++YC N P + + ++ FF+ C R L+ + +D +LL PV
Sbjct: 322 LQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEAC-RLLQQMIDIAIDGFLLTPV 380
Query: 693 QRITKYQLLLKELLKYSKDCEGS-ALLKKALDAMLDLLKSVND-----------SMHQIA 740
Q+I KY L L ELLKY+ G + +K A +AM ++ +N+ + Q++
Sbjct: 381 QKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVS 440
Query: 741 INGYIG--NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKR 798
I G+ G L+ ++I G + K + K QR FL++ +V CK+
Sbjct: 441 IVGWEGLDILDRSSELIHSGELT------------KITKQGKSQQRTFFLFDHQLVSCKK 488
Query: 799 RVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQ 850
+ R +K MDE+ + + G ++ F++ +EVY+
Sbjct: 489 DLL------RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFC 542
Query: 851 ASNVDVKMTWLKEIRNILLKQQE 873
A + K WL+ + + QE
Sbjct: 543 AKKQEDKARWLQACADERRRVQE 565
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 97.8 bits (242), Expect = 4e-20
Identities = 100/417 (23%), Positives = 179/417 (42%), Gaps = 74/417 (17%)
Query: 522 NQSNLKIEVVPDCQEKRSSGPSSSLDNGNSL---DVLKNHVLNELIQTERVYVRELYTVL 578
NQ + E D Q S L G L D ++ +V+NE++ TER Y++ L +
Sbjct: 67 NQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDIC 126
Query: 579 LGYRAEM-DNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----R 633
GY + +MF + ++FGN+ +IY F F+ LE + +
Sbjct: 127 EGYLKQCRKRRDMFS------DEQLKVIFGNIEDIYRFQMG-FVRDLEKQYNNDDPHLSE 179
Query: 634 VGPCFLERKDDFQMYAKYCQNK----PRSETIWRKYSECAFFQECQRKLKHR--LRLDSY 687
+GPCFLE +D F +Y++YC N + + FF+ C R L+ + +D +
Sbjct: 180 IGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEAC-RLLQQMIDIAIDGF 238
Query: 688 LLKPVQRITKYQLLLKELLKY-SKDCEGSALLKKALDAMLDLLKSVND-----------S 735
LL PVQ+I KY L L ELLKY ++D + AL M ++ + +N+ +
Sbjct: 239 LLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIA 298
Query: 736 MHQIAINGYIG-NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIV 794
Q ++ + G ++ + ++ G WI G + QR FL++ +V
Sbjct: 299 QWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYG----------RNQQRVFFLFDHQMV 348
Query: 795 FCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDN--------RKFEIWYGEKEEV 846
CK+ + R +K MD+ + + G + F++ E EE+
Sbjct: 349 LCKKDL------IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEI 402
Query: 847 YIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQ 903
++ A ++ K+ WL+ R+++ + E +K + +N ++Q
Sbjct: 403 HLFFAKKLEEKIRWLRAF---------------REERKMVQEDEKIGFEISENQKRQ 444
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 90.1 bits (222), Expect = 9e-18
Identities = 81/285 (28%), Positives = 134/285 (47%), Gaps = 41/285 (14%)
Query: 541 GPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRN 600
GP ++ L+ VLNE++ TER YV L + + + + L
Sbjct: 35 GPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEE 94
Query: 601 KKDILFGNMAEIYEFHNDIFLSSLENCAH----APERVGPCFLERKDDFQMYAKYCQNKP 656
+LF N+ +I E H D FL++LE C H + +G FL+ KD F +Y +YC N
Sbjct: 95 NVKVLFSNIEDILEVHKD-FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHE 153
Query: 657 RSETIWRKYSEC----AFFQECQ----RKLKHRLRLDSYLLKPVQRITKYQLLLKELLKY 708
++ + + ++ AF C RK + L+ YLL P+QRI KY LLLKEL K
Sbjct: 154 KALRLLVELNKIPTVRAFLLSCMLLGGRKTTD-IPLEGYLLSPIQRICKYPLLLKELAKR 212
Query: 709 SKDCE-GSALLKKALDAMLDLLKSVNDSMHQIA-----------INGYIG-NLNEL-GKM 754
+ ++ AL AM + ++N++ Q+ I G+ G NL ++ ++
Sbjct: 213 TPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQL 272
Query: 755 IMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRR 799
++QG T +K ++ +R FL++ +V+CKR+
Sbjct: 273 LLQG------------TLLK-ISAGNIQERAFFLFDNLLVYCKRK 304
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 90.1 bits (222), Expect = 9e-18
Identities = 76/285 (26%), Positives = 134/285 (47%), Gaps = 42/285 (14%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL+EL +TER YV L ++ + M+ + + +LF N+ +I H +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 619 IFLSSLENCAH----APERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSEC----AF 670
FL +E C H A + VG CFL KD F++Y +YC N +++ + + ++ F
Sbjct: 87 -FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 671 FQECQR---KLKHRLRLDSYLLKPVQRITKYQLLLKELLKYS-KDCEGSALLKKALDAML 726
C + + L+ YL+ P+QRI KY L+LKELLK + + A + +AL AM
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 727 DLLKSVNDSMHQIA-----------INGYIGN--LNELGKMIMQGGFSVWIGHKKGATKM 773
+ ++N++ Q+ I G+ G+ + +M+M G +
Sbjct: 206 AVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCG-------------VL 252
Query: 774 KDLARFKPMQRHLFLYEKAIVFCK---RRVESGEGSDRYPSYSFK 815
++ +R FL++ +V+CK RR+++ + S Y F+
Sbjct: 253 LKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFR 297
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 90.1 bits (222), Expect = 9e-18
Identities = 76/285 (26%), Positives = 134/285 (47%), Gaps = 42/285 (14%)
Query: 559 VLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHND 618
VL+EL +TER YV L ++ + M+ + + +LF N+ +I H +
Sbjct: 27 VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
Query: 619 IFLSSLENCAH----APERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSEC----AF 670
FL +E C H A + VG CFL KD F++Y +YC N +++ + + ++ F
Sbjct: 87 -FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145
Query: 671 FQECQR---KLKHRLRLDSYLLKPVQRITKYQLLLKELLKYS-KDCEGSALLKKALDAML 726
C + + L+ YL+ P+QRI KY L+LKELLK + + A + +AL AM
Sbjct: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
Query: 727 DLLKSVNDSMHQIA-----------INGYIGN--LNELGKMIMQGGFSVWIGHKKGATKM 773
+ ++N++ Q+ I G+ G+ + +M+M G +
Sbjct: 206 AVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCG-------------VL 252
Query: 774 KDLARFKPMQRHLFLYEKAIVFCK---RRVESGEGSDRYPSYSFK 815
++ +R FL++ +V+CK RR+++ + S Y F+
Sbjct: 253 LKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFR 297
>gi|55749621 pleckstrin homology domain containing, family G, member
3 [Homo sapiens]
Length = 1163
Score = 86.3 bits (212), Expect = 1e-16
Identities = 68/257 (26%), Positives = 117/257 (45%), Gaps = 43/257 (16%)
Query: 644 DFQMYAKYCQNKPRSETI----WRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQ 699
+F +Y +YC N P S R + FF++ Q L+H L L SYLLKPVQRI KY
Sbjct: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
Query: 700 LLLKELLK-YSKDCEGSALLKKALDAMLDLLKSVND------------SMHQIAINGYIG 746
LLL+E+ K + ++ +G +++ A+D M + +ND + + IN
Sbjct: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
Query: 747 NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGS 806
+L G+++++G F V H+ +R FL++K ++ K+R
Sbjct: 240 DLTTYGELVLEGTFRV---HR------------VRNERTFFLFDKTLLITKKR------G 278
Query: 807 DRYPSYSFKHCWKMDEVGITEYVKGDNRKFEI-WYGEKEEVYIVQASNVDVKMTWLKEIR 865
D + C + + T D+ F + Y ++ Y +QA V+ K W I+
Sbjct: 279 DHFVYKGNIPCSSLMLIESTR----DSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIK 334
Query: 866 NILLKQQELLTVKKRKQ 882
++L+ +K K+
Sbjct: 335 RLILENHHATIPQKAKE 351
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,872,112
Number of Sequences: 37866
Number of extensions: 1490596
Number of successful extensions: 5738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 5217
Number of HSP's gapped (non-prelim): 503
length of query: 985
length of database: 18,247,518
effective HSP length: 112
effective length of query: 873
effective length of database: 14,006,526
effective search space: 12227697198
effective search space used: 12227697198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.