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Search of human proteins with 151301171
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|151301171 RNA polymerase II transcription factor TAFII140
[Homo sapiens]
(929 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 1880 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 127 5e-29
gi|110349719 titin isoform N2-A [Homo sapiens] 110 6e-24
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 101 3e-21
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 101 3e-21
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 99 2e-20
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 98 3e-20
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 98 3e-20
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso... 94 6e-19
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 91 4e-18
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 88 3e-17
gi|12711674 UPF3 regulator of nonsense transcripts homolog B iso... 88 4e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 87 7e-17
gi|11225260 DNA topoisomerase I [Homo sapiens] 84 5e-16
gi|125656165 THO complex 2 [Homo sapiens] 84 6e-16
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 84 6e-16
gi|104526627 triadin [Homo sapiens] 84 8e-16
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 82 2e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 81 5e-15
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 80 1e-14
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 78 3e-14
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 78 4e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 78 4e-14
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 77 1e-13
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 77 1e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 77 1e-13
gi|38788274 bromodomain PHD finger transcription factor isoform ... 75 4e-13
gi|34878777 ring finger protein 20 [Homo sapiens] 75 4e-13
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 74 6e-13
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 73 1e-12
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 1880 bits (4871), Expect = 0.0
Identities = 929/929 (100%), Positives = 929/929 (100%)
Query: 1 MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTD 60
MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTD
Sbjct: 1 MCESYSRSLLRVSVAQICQALGWDSVQLSACHLLTDVLQRYLQQLGRGCHRYSELYGRTD 60
Query: 61 PILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEER 120
PILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEER
Sbjct: 61 PILDDVGEAFQLMGVSLHELEDYIHNIEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEER 120
Query: 121 KEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRP 180
KEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRP
Sbjct: 121 KEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRP 180
Query: 181 LDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLA 240
LDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLA
Sbjct: 181 LDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLA 240
Query: 241 PPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR 300
PPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR
Sbjct: 241 PPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR 300
Query: 301 SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK 360
SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK
Sbjct: 301 SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK 360
Query: 361 QIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIF 420
QIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIF
Sbjct: 361 QIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIF 420
Query: 421 TSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLG 480
TSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLG
Sbjct: 421 TSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLG 480
Query: 481 TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQR 540
TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQR
Sbjct: 481 TPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQR 540
Query: 541 DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP 600
DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP
Sbjct: 541 DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP 600
Query: 601 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE 660
KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE
Sbjct: 601 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE 660
Query: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE 720
LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE
Sbjct: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE 720
Query: 721 KEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPA 780
KEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPA
Sbjct: 721 KEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPA 780
Query: 781 PEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASA 840
PEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASA
Sbjct: 781 PEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASA 840
Query: 841 KAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTA 900
KAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTA
Sbjct: 841 KAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCDDCDDWYHWPCVGIMTA 900
Query: 901 PPEEMQWFCPKCANKKKDKKHKKRKHRAH 929
PPEEMQWFCPKCANKKKDKKHKKRKHRAH
Sbjct: 901 PPEEMQWFCPKCANKKKDKKHKKRKHRAH 929
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 127 bits (319), Expect = 5e-29
Identities = 168/664 (25%), Positives = 262/664 (39%), Gaps = 97/664 (14%)
Query: 89 PVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGG 148
P + P +P P ++ +EE+ + + V +E+ EE QV T+
Sbjct: 419 PFSLPEGLPKIPSVSTHI-------KVKSEEKIKVVEKSEKETVIVEEQTEETQV-TEEV 470
Query: 149 TSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVV 208
T E + EE E E E +E G+ SP AEE + ++
Sbjct: 471 TEEEEKEAKEEEGKEEEGGE--EEEAEGGEEETKSPPAEEAASPEK-------------- 514
Query: 209 LLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSF 268
EA+ SPV + + SPE AKS P + KS
Sbjct: 515 --EAK---------------SPVKEEAKSPAEAKSPEKEE----AKSPAEVKSPEKAKS- 552
Query: 269 TPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTT 328
P + S P K+ + A+SPA V SP ++ +E KSP +KSP+ KSP
Sbjct: 553 -PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP--VK 609
Query: 329 HIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSE--NQPKKAVVADKT 386
++P ++P + +E ++++P A E P+KA +K
Sbjct: 610 EEAKSPAEAKSP-----------VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Query: 387 IEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKS 446
S + + AE + P + S ++E SP++ P K+ A + K
Sbjct: 659 EAKSPEKAKSPVKAEAK-SPEKAKSPVKAEA---KSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 447 GSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPY--ISSPSVSPPTPE- 503
P + + + T + + V +AK + P + SP P E
Sbjct: 715 -EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Query: 504 ---PLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVK 560
P K + EK K P VK+++K K K KE + E+E K K + K VK
Sbjct: 774 ARSPADK-FPEKAKSP----VKEEVKSPEKAKSPLKEDAKAPEKEIPK---KEEVKSPVK 825
Query: 561 EKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK 620
E+EK +E + K P K+ EEE P K +E +D + K KE K K
Sbjct: 826 EEEKPQEV--KVKEPPKK--AEEEKAPATPKTEEKKDSKKEEAPK-------KEAPKPKV 874
Query: 621 KDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPS 680
+++++ +K K K + K + EDK K P P P K P + V P
Sbjct: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 681 LLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKH 740
K E + ++KE +KK+ K++K K+ E+K K K K + + KE K
Sbjct: 935 -----DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989
Query: 741 KHEK 744
K EK
Sbjct: 990 KAEK 993
Score = 95.9 bits (237), Expect = 2e-19
Identities = 123/514 (23%), Positives = 207/514 (40%), Gaps = 72/514 (14%)
Query: 321 PKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKA 380
PK P V+THI V+ E + + EK KET+ V++ + +E + K+A
Sbjct: 427 PKIPSVSTHIK---VKSEEKIK-----VVEKSEKETVIVEEQTEETQVTEEVTEEEEKEA 478
Query: 381 VVAD-KTIEASIDAVIARACAEREPDPFEFSSGSESEG-----DIFTSPKRISGPECTTP 434
+ K E + E + P E ++ E E + SP PE
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 435 KASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDA-SIDEVVRKAKLGTPSNMPPNFPY-I 492
K+ + K+ S + + + +A S EV K +P+ P
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 493 SSP--SVSP-----PTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRERE 545
SP + SP +P +E+ K P+ V+ +K K K + K EK + E+E
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Query: 546 KDKNKDKSKEKDKVKEKEKDK---------ETGRETKYPWKEF----------LKEEEAD 586
+ K+ +K+K K + K +K ++ + K P KE +KEE
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Query: 587 PYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGRE-- 644
P K K E+ K K + + K K K ++ K K K K++ R
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778
Query: 645 ----DKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700
+K K+P V P++ PL A A PEK +KE+VK
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA--------------PEKEIPKKEEVKSPV 824
Query: 701 KKKDKKEKKKKKEKEKEKKEKE-----REKEKREREKREKEKEKHKHEKIKVEPVALAPS 755
K+++K ++ K KE K+ +E++ + +EK++ +K E K++ K++ +
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884
Query: 756 PVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQ 789
P ++ + +DK K VP PE K AP++
Sbjct: 885 PKESKVEAKKEEAEDK----KKVPTPE-KEAPAK 913
Score = 77.0 bits (188), Expect = 7e-14
Identities = 89/366 (24%), Positives = 140/366 (38%), Gaps = 27/366 (7%)
Query: 482 PSNMPPNFPYISSPSVSPPTP-EPLHKVYEEKTKLPSSVEVKKKLKK------ELKTKMK 534
P ++P P I S S E KV E+ K VE + + + E + K
Sbjct: 419 PFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEA 478
Query: 535 KKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKE--EEADPYKFKI 592
K+E+ ++ E +++ + +E+ K E+ +E K P KE K E P K +
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 593 KEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGRED------- 645
K +V K K + K + K ++E+ K + + EK K +E+
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 646 ----KMKAPAPPLVLPPKELALPLFSPATA-SRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700
K K+P P E P+ A + + V + + P E EK K EKE
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Query: 701 KKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPR 760
+ K ++ K + E + EK + K E + EK K K E E A SPV
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK---AKSPVKEE 715
Query: 761 LTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQ 820
A K + + PE +P + K+P A +P L +P +
Sbjct: 716 AKSPEKA---KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772
Query: 821 AAAGPA 826
A PA
Sbjct: 773 EARSPA 778
Score = 56.6 bits (135), Expect = 1e-07
Identities = 59/194 (30%), Positives = 90/194 (46%), Gaps = 24/194 (12%)
Query: 674 VPAMLPSLLPVLP------EKLFEEKEKVKEKEKKK-----DKKEKKKKKEKEKEKKEKE 722
+P LP LP +P + EEK KV EK +K+ ++ E+ + E+ E++EKE
Sbjct: 418 IPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKE 477
Query: 723 -REKEKREREKREKEKEKHKHEKIK-------VEPVALAPSPVIPRLTLRVGAGQDKIVI 774
+E+E +E E E+E+ + E+ K P A SPV A +
Sbjct: 478 AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEE 537
Query: 775 SK---VVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPSP 831
+K V +PE +P++ K+PP A +P SPA V P A++ A SP
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK-EEAKSPAEVKSPEKAKSPAKEE-AKSP 595
Query: 832 GPAASGASAKAPVR 845
A S AK+PV+
Sbjct: 596 AEAKSPEKAKSPVK 609
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 110 bits (275), Expect = 6e-24
Identities = 185/771 (23%), Positives = 291/771 (37%), Gaps = 114/771 (14%)
Query: 132 VSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPA 191
+ +EE E + + G E + E +EEE + + R ++ EAEE+
Sbjct: 10377 IPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVH----RVIEVFEAEEVEV 10432
Query: 192 MKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSP-----VHVQDSTDLAPPSPEP 246
++P+ KG + ++ ++P + + +K PP P + V++ + PE
Sbjct: 10433 FEKPKA-PPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRV----PEE 10487
Query: 247 PMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVS 306
P + P +++P P K P+ K P +K ++P A PK V
Sbjct: 10488 PRVPP---TKVPEVLP--PKEVVPEKKVPVP-PAKKPEAPPPKVPEA--------PKEVV 10533
Query: 307 KEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPP 366
EKK P PK P+ P T +P+ P A + EK E I K PP
Sbjct: 10534 PEKKVP--VPPPKKPEVPP--TKVPEVP----------KAAVPEKKVPEAIPPKPESPPP 10579
Query: 367 DAGKLNSENQPKKAVVADKTIEASIDAV-IARACAEREPD---PFEFSSGSESEGDIFTS 422
+ + E P+K V A + + V + A E P+ P E
Sbjct: 10580 EVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPE 10639
Query: 423 PKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTP 482
+++ PE P+A +P P ++ EVV + + P
Sbjct: 10640 VPKVAVPEKKVPEA------IPPKPESPPP---EVFEEPEEVALEEPPAEVVEEPEPAAP 10690
Query: 483 SNM--PPN--FPYISSPSVSPPTPE---------PLHKVYEEKTKL---------PSSV- 519
+ PP P +P+V PE P V E+K L P+ V
Sbjct: 10691 PQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVP 10750
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEF 579
EV K++ E K + KK + + + K +EK V E+ + E +E
Sbjct: 10751 EVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEI 10810
Query: 580 LKEEEADPYKFK---IKEFEDVD---PKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKR 633
EEE P + K + E E+ + P V + + EK+ KK + K+ + ++
Sbjct: 10811 APEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEK 10870
Query: 634 EKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEK 693
EK K K R P PP PPKE A +P P +PEK+
Sbjct: 10871 VIEKPKLKPR------PPPPPPAPPKEDVKEKIFQLKA--IPKKKVPEKPQVPEKVELTP 10922
Query: 694 EKVKEKEKKKDKKEKKKKKEKEKE-------KKEKEREKEKREREKREKEKEKHKHEKIK 746
KV EKK K ++K E ++E +K E E+ K E +K EK K+ E
Sbjct: 10923 LKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPP 10982
Query: 747 VEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRP----KTPPPAPAPA 802
+PV P + + ++ I +P P +P P K PP P P
Sbjct: 10983 PKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPT 11042
Query: 803 PGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVS 853
P APV +P++ + A A P A K P++ V +T S
Sbjct: 11043 P-----IAAPVTVPVVGKKAEAKA------PKEEAAKPKGPIKGVPKKTPS 11082
Score = 91.7 bits (226), Expect = 3e-18
Identities = 193/844 (22%), Positives = 295/844 (34%), Gaps = 136/844 (16%)
Query: 120 RKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLG-- 177
RKE P P V + E EE + T E V EE+ EEEE I +E +
Sbjct: 9887 RKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVI 9946
Query: 178 ---------------KRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREP----LSS 218
K+P+ P+ +E P K P + + + V++ + +P +
Sbjct: 9947 PVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPE 10006
Query: 219 INTQKIPPMLSPVHVQDSTDLAPPS--PEPPML-APVAKSQMPTAKPLETKSFTPKTKTK 275
+ + +P PV V + APP+ PE P P K +P K +E K
Sbjct: 10007 VPKKPVPEEKVPVPVPKKVE-APPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPK 10065
Query: 276 TSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPV 335
P +K +P P V +P PK K + P P+ + +P+ V
Sbjct: 10066 KLIPEEKKPTPV----PKKVEAP--PPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEV 10119
Query: 336 RPETPNRTPSA--TLSEKIS----KETIQVKQIQTPPDAGKLNSENQ--PKKAVVADKTI 387
PE P L E+ +E I ++ + PP+ + E + P++ V+ +
Sbjct: 10120 LPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKP 10179
Query: 388 EASIDAV---IARACAERE---PDPFEFSSGSESEGDIFTSPKRISGP--ECTTPKASTS 439
+ + A I + E++ P E E KRI P E P T
Sbjct: 10180 KVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTE 10239
Query: 440 ANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPY----ISSP 495
+P S + + EV++KA P+ +P +S
Sbjct: 10240 EPEEEPISEEEIP-EEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKK 10298
Query: 496 SVSPPTPEPLHKVYEEKTKLPSSVEVKKKL--KKELKTKMKKKEKQRDREREKDKNKDKS 553
P P+ K K+P EV KK+ KK L K + + R ++K
Sbjct: 10299 IPEEKVPVPVQKKEAPPAKVP---EVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAF 10355
Query: 554 KEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYK--FKIKEFEDVDPKVKLKDGLVRK 611
+++ VKE+ + + E + E +EEE + F+ EF +V+ +KL+ V +
Sbjct: 10356 RQEVVVKERLELEVVEAEVE----EIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEE 10411
Query: 612 EKEKHK----------------DKKKDREKG-------------------KKDKDKREKE 636
E K +K K KG +K+ + E
Sbjct: 10412 EHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPE 10471
Query: 637 KVKDKGREDKMKAPAPPLV--------LPPKELALPLFSPATASRVPAMLPSLLPVLPEK 688
K E+K++ P P V LPPKE+ P ++ P P +P P++
Sbjct: 10472 VPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKE 10531
Query: 689 LFEEKEKVKEKEKKKDKKEKKKKKEKEK----EKKEKEREKEKRER---EKREKEKEKHK 741
+ EK KV KK + K E K EKK E K E E E KE
Sbjct: 10532 VVPEK-KVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVP 10590
Query: 742 HEKIKVEP----------VALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNR 791
+K+ P V AP V+P + V + V VP P +
Sbjct: 10591 EKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKV 10650
Query: 792 PKTPPPAPAPAPGPMLVSPAPV------------PLPLLAQAAAGPALLPSPGPAASGAS 839
P+ PP P P + P V P P P P P A
Sbjct: 10651 PEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVV 10710
Query: 840 AKAP 843
AK P
Sbjct: 10711 AKKP 10714
Score = 82.4 bits (202), Expect = 2e-15
Identities = 183/872 (20%), Positives = 311/872 (35%), Gaps = 169/872 (19%)
Query: 114 SKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGT----SAEAMQVPLEEDDELE---- 165
+K E K+ +P P QEE E +VP S E M ++E+
Sbjct: 9204 TKVPEVSKKIVPQK-PSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVP 9262
Query: 166 --EEEIINDENF---LGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREP----L 216
++EI+ +E + KR P+ ELP P + V + + EP +
Sbjct: 9263 EVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPE------EVAPVPIPKKVEPPAPKV 9316
Query: 217 SSINTQKIPPMLSPVHVQDSTDLAPPS-PEPPMLAPVAKSQMPTAKPLETKSFTPKTKTK 275
+ + +P PV V APP PE P PV + ++P P+ K P K
Sbjct: 9317 PEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPK-KPVPEEKIPV--PVAKKKEAPPAKVP 9373
Query: 276 TSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSK---EKKSPGRSKSPKSPKSPKVTTHIPQ 332
G T+ T + P P+ K E++ P K + P PKV +P+
Sbjct: 9374 EVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPA-LPK 9432
Query: 333 TPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASID 392
PV PE P + V + PP A +K VA++ + ++
Sbjct: 9433 KPV-PEEKVAVP------------VPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVP 9479
Query: 393 AVIARACAEREPDPFEFSSGSESEG---DIFTSPKRISGPECTTPKASTSANNFTKSGST 449
+ E + E+S E EG ++ +R E +
Sbjct: 9480 QRVEVTRHEVSAEE-EWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEE 9538
Query: 450 PLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPS------------- 496
L + ++ + + ++V K K+ PP +P
Sbjct: 9539 KLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVP 9598
Query: 497 ----VSPP-TPEPLHKVYEEKTKLPSSVEVKKKL--------------KKELKTKMKKKE 537
V PP PE K EK P +++++ L +K L KK+
Sbjct: 9599 KKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEA 9658
Query: 538 KQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEE---------EADPY 588
+ R E+ K ++ K+K K +++ + T++ K +KEE E P
Sbjct: 9659 PPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFR-KRVVKEEKVSIEAPKREPQPI 9717
Query: 589 KFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKD-----------REKGKKDKDKREKEK 637
K ++ E+ + L++ V ++E+ ++ ++ E+ + ++ E+E
Sbjct: 9718 K-EVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREY 9776
Query: 638 VKDKGREDKMKAPAPPLVLPP--------KELALP---LFSPATASRVPAMLPSLL---- 682
+ + E+ + P P+ + P K A P L +VP +P L
Sbjct: 9777 ERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPP 9836
Query: 683 ---PVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREK------- 732
P P+K+FEEK ++ +++K++ + K K K+ EK R++
Sbjct: 9837 PKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRV 9896
Query: 733 ----REKEKE-----------------KHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDK 771
+E E E + + E I E + V+P + ++V K
Sbjct: 9897 PEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRK 9956
Query: 772 IV--ISKVVPAPEAKPAPSQNRPKT-----------------PPPAPAPAPGPMLVSPAP 812
V K VP P+ K AP P+ PPPA P V
Sbjct: 9957 PVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEK 10016
Query: 813 VPLPLLAQAAAGPALLPSPGPAASGASAKAPV 844
VP+P+ + A PA +P P K PV
Sbjct: 10017 VPVPVPKKVEAPPAKVPEV-PKKPVPEKKVPV 10047
Score = 82.0 bits (201), Expect = 2e-15
Identities = 175/766 (22%), Positives = 274/766 (35%), Gaps = 132/766 (17%)
Query: 88 EPVTFPHQIPSFPVSKNNVLQFPQ--PGSKDAEERKEYIPDYLPPIVSSQEE---EEEEQ 142
EPV P +P + VL + P + E +E +P+ +EE EEEE
Sbjct: 10093 EPVPVPVALPQ----EEEVLFEEEIVPEEEVLPEEEEVLPE--------EEEVLPEEEEV 10140
Query: 143 VPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKG 202
+P + E +VP EE+ EEEE + +E L + P +P +K K
Sbjct: 10141 LPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIK-------KK 10193
Query: 203 DTLDVVLLEAREPLSSINTQKIPPMLSPVHV---QDSTDLAPPSPEPPMLAPVAKSQMPT 259
T V++ +E ++P + + ++ L E P P+++ ++P
Sbjct: 10194 VTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPE 10253
Query: 260 AKPL--ETKSFTP---KTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEK-KSPG 313
P E + P K + P T PK ++P P + K + +EK P
Sbjct: 10254 EPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAP-----PAKVSKKIPEEKVPVPV 10308
Query: 314 RSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNS 373
+ K K P+V +P+ K+ + K+ PP G+
Sbjct: 10309 QKKEAPPAKVPEVPKKVPE---------------------KKVLVPKKEAVPPAKGRTVL 10347
Query: 374 ENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSE--SEGDIFTSPKRISGPEC 431
E + A + ++ ++ + A E P+ EF E EG+ + I
Sbjct: 10348 EEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIK---- 10403
Query: 432 TTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPY 491
+ + + + + +A EV K K PP P
Sbjct: 10404 -LEQHRVEEEHRVEKVHRVIEV------------FEAEEVEVFEKPK------APPKGPE 10444
Query: 492 ISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKD 551
IS + P P KV K EV KK+ E K ++ ++ +
Sbjct: 10445 ISEKIIPPKKPPT--KVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPR------------- 10489
Query: 552 KSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEF-EDVDPKVKLKDGLVR 610
KV E KE E K P K E P K+ E ++V P+ K+ V
Sbjct: 10490 --VPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAPPP---KVPEAPKEVVPEKKVP---VP 10541
Query: 611 KEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPAT 670
K+ K E K EK + K ++P P + PKE+ PA
Sbjct: 10542 PPKKPEVPPTKVPEVPK----AAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAA 10597
Query: 671 ASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEK----EKKEKEREKE 726
+ P + P +P P+++ EK KV KK + K E K EKK E
Sbjct: 10598 PPKKPEVTPVKVPEAPKEVVPEK-KVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPP 10656
Query: 727 KREREKRE--KEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAK 784
K E E +E E+ E+ E V P P P ++ + P PE K
Sbjct: 10657 KPESPPPEVFEEPEEVALEEPPAE-VVEEPEPAAP----------PQVTVPPKKPVPEKK 10705
Query: 785 -PAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLP 829
PA +P+ PP P +V VPL + + A PA +P
Sbjct: 10706 APAVVAKKPEL-PPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVP 10750
Score = 69.7 bits (169), Expect = 1e-11
Identities = 97/416 (23%), Positives = 169/416 (40%), Gaps = 63/416 (15%)
Query: 495 PSVSPPTPEPLHKVYEEKTKLPSSVEV-KKKLKKELKTKMKKKEKQRDREREKDKNK--- 550
P V+PP P L EEK P +EV KK +KK+ K + K ++ RE K
Sbjct: 8959 PVVAPPIPLLL-PTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPT 9017
Query: 551 -----------DKSKEKDKV--------KEKEKDKETGRETKY-----------PWKEFL 580
D S + ++V KE +K+KE E K ++E
Sbjct: 9018 TLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPY 9077
Query: 581 KEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKD 640
E E +PY ++ +P ++ V +KE H++ ++D E+G ++ E+E+ D
Sbjct: 9078 DELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEG---QEYYEREEGYD 9134
Query: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEK--EKVKE 698
+G E+ +A V+ ++ ++ + +VPA +P P K+ ++ EK+++
Sbjct: 9135 EGEEEWEEAYQEREVI---QVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEK 9191
Query: 699 KEKKKDKKEKKKKKEKEKEKK---EKEREKEKREREKREKEKEKHKHEKIKVEPVALAPS 755
++ ++++ + K E KK +K +E K H + + E S
Sbjct: 9192 TSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFAS 9251
Query: 756 PVIPRLTLRVGAGQDKIV--------ISK-VVPAPEAKPAPSQNRPKTPPPAPAP----A 802
+++ V Q +IV ISK V P P+ P + P+ P P P
Sbjct: 9252 HTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEP 9311
Query: 803 PGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVSTYVIR 858
P P + P+P P +P PAA + P + V E + V +
Sbjct: 9312 PAPKVPEVPKKPVP----EEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAK 9363
Score = 64.3 bits (155), Expect = 5e-10
Identities = 116/554 (20%), Positives = 194/554 (35%), Gaps = 73/554 (13%)
Query: 88 EPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDG 147
+P P ++P P + P P K E +P+ +P + +++ E P
Sbjct: 10601 KPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPE-VPKVAVPEKKVPEAIPPKPE 10659
Query: 148 GTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDV 207
E + P E E E++ + + P + +P K P +++ K + V
Sbjct: 10660 SPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPV 10719
Query: 208 VLLEAREPLSSINTQKIP------PMLSPVHVQDSTDLAPPS-----PEPPMLAPVAKSQ 256
+ E P + +K+P P P V + P P+ P + P +
Sbjct: 10720 KVPEV--PKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPE 10777
Query: 257 MPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVG----SPI------------- 299
+P LE K P + S P + + P+ + P+
Sbjct: 10778 VPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPP 10837
Query: 300 ---RSPKTVSKEKKSPGRSK----SPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKI 352
PK + EKK P K PK P+ KV P P P P + EKI
Sbjct: 10838 AVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKI 10897
Query: 353 SK-ETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSS 411
+ + I K++ P + E P K +K + + ER+P+P E
Sbjct: 10898 FQLKAIPKKKVPEKPQVPE-KVELTPLKVPGGEKKVR--------KLLPERKPEPKE--- 10945
Query: 412 GSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASID 471
++ PE PK K + P P T+
Sbjct: 10946 ------EVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTV----- 10994
Query: 472 EVVRKAKLGTPSNMPPNFPYISSPSVSP-PTPEPLHK------VYEEKTKLPSSVEVKKK 524
R+ K+ P+ +P P I P+ P P PE K V E T + + V V
Sbjct: 10995 -TKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTV-PV 11052
Query: 525 LKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEE 584
+ K+ + K K+E + + K K K+ + + ++ +G E F + +
Sbjct: 11053 VGKKAEAKAPKEEAAKPKGPIKGVPK-KTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLK 11111
Query: 585 ADPYKFKIKEFEDV 598
A P KF +KE +D+
Sbjct: 11112 AVPLKF-VKEIKDI 11124
Score = 60.1 bits (144), Expect = 9e-09
Identities = 147/713 (20%), Positives = 255/713 (35%), Gaps = 119/713 (16%)
Query: 87 IEPVTFPHQIPSFPVSKNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVPTD 146
+EP T P + P + + + K+ E E+ D+ QE E E+ +
Sbjct: 9082 VEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHE--EWEEDF----EEGQEYYEREEGYDE 9135
Query: 147 GGTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELP---AMKRPRL-----L 198
G E + +E + ++ ++ + +E+ K P PE + P +K+P +
Sbjct: 9136 G---EEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKT 9192
Query: 199 STKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPP--------SPEPPMLA 250
S + + V + + E I QK P +PV + P S E A
Sbjct: 9193 SRRMEEEKVQVTKVPEVSKKIVPQK--PSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFA 9250
Query: 251 PVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKK 310
+ ++ P K + K + + PK + P +P + K K
Sbjct: 9251 SHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPK-KV 9309
Query: 311 SPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLS-EKISKETIQVKQIQTPPDAG 369
P K P+ PK P +P+ P + P+A ++ K+ + ++I P
Sbjct: 9310 EPPAPKVPEVPKKP-----VPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKK 9364
Query: 370 KLNSENQPKKAVVADKTIEASIDAVIARACAEREPD----------PFEFSSGSESEGDI 419
K E P K K + I E P P E E ++
Sbjct: 9365 K---EAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEV 9421
Query: 420 FTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKL 479
PK + P+ P+ + P+P V +KA
Sbjct: 9422 PPPPKVPALPKKPVPEEKVAV---------PVP--------------------VAKKA-- 9450
Query: 480 GTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTK--LPSSVEVKKKLKKELKTKMKKKE 537
PP +S +V E V EEK +P VEV + ++ +E
Sbjct: 9451 ------PPPRAEVSKKTVV----EEKRFVAEEKLSFAVPQRVEVTRH-------EVSAEE 9493
Query: 538 KQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED 597
+ E E+ + +E+++ +E+E+ + T E +E++ EE+ ++ E E
Sbjct: 9494 EWSYSEEEEGVSISVYREEER-EEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRV-EAEP 9551
Query: 598 VDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLP 657
+ + + +V K K K ++ K + K EK K K P P +
Sbjct: 9552 AEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEE 9611
Query: 658 PKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK------KKDKKEKKKK 711
PK+ P +VP + + LP K+ E ++ ++EK KK+ K +
Sbjct: 9612 PKK-------PVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARV 9664
Query: 712 KEKEKEKKEKERE---KEKREREKREK----EKEKHKHEKIKVEPVALAPSPV 757
E+ K +E+ K KRE E K K K EK+ +E P P+
Sbjct: 9665 PEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPI 9717
Score = 58.2 bits (139), Expect = 4e-08
Identities = 123/570 (21%), Positives = 218/570 (38%), Gaps = 83/570 (14%)
Query: 321 PKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQV---KQIQTPPDAGKLNSENQP 377
P+ P +P+ PV P P P+ L + + +E + V K+++ PP +P
Sbjct: 9789 PEKPIPVKPVPEEPV-PTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPP----KVPEEP 9843
Query: 378 KKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKAS 437
KK V ++ I SI +RE + +E + PKR+ E P
Sbjct: 9844 KK--VFEEKIRISI--------TKREKEQV-----TEPAAKVPMKPKRVVAEE-KVPVPR 9887
Query: 438 TSANNFTKSGSTPLPLSGGTSSSDNS-------WTMDASIDEVVRKAKLGTPSNMPPNFP 490
+ P L + + + ++ + + + + T + P P
Sbjct: 9888 KEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIP 9947
Query: 491 YISSPSVSPPTPEPLHK----VYEEKTKLPSSV-EVKKKLKKELKTKMKKKEKQRDRERE 545
+ P V P P P K V ++K P+ V EV KK ++++ + KKEK +
Sbjct: 9948 -VKVPEV-PRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVP 10005
Query: 546 KDKNKDKSKEKDKVKEKEK-DKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604
+ K +EK V +K + + + P K +++ P K++ P+V
Sbjct: 10006 EVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPK 10065
Query: 605 KDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAP-PLVLPPKELAL 663
K L+ +EK+ KK K KRE P P P+ LP +E L
Sbjct: 10066 K--LIPEEKKPTPVPKKVEAPPPKVPKKRE---------------PVPVPVALPQEEEVL 10108
Query: 664 PLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKER 723
V +LP E L EE+E + E+E+ ++E+ +E+ ++E+
Sbjct: 10109 FEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFV 10168
Query: 724 EKEKREREKREKE---------KEKHKHEKIKVEPVALAPSPVIPRLTLRVGAG------ 768
+E+ E + K K+K +K+ + AP +P + +V
Sbjct: 10169 PEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPK 10228
Query: 769 QDKIVISKVVPAPEAKPAPSQNRPKTPPPAP-----APAPGPMLV------SPAPVPLPL 817
+++++ +V PE +P + P+ PP AP P ++ +P PVP +
Sbjct: 10229 EEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKV 10288
Query: 818 LAQAAAGPALLPSPGPAASGASAKAPVRSV 847
A A +P +AP V
Sbjct: 10289 EAPPAKVSKKIPEEKVPVPVQKKEAPPAKV 10318
Score = 56.2 bits (134), Expect = 1e-07
Identities = 125/572 (21%), Positives = 203/572 (35%), Gaps = 129/572 (22%)
Query: 306 SKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTP 365
S E+K P + K+P PKV + P S ++ +E +QV ++
Sbjct: 9160 SHERKVPAKVPEKKAPPPPKVI----------KKPVIEKIEKTSRRMEEEKVQVTKV--- 9206
Query: 366 PDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKR 425
P+ K +P + V ++ IE + AV + E F F+S +E E +
Sbjct: 9207 PEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMF-FASHTEEEVSV------ 9259
Query: 426 ISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNM 485
T P+ K V +K P
Sbjct: 9260 ------TVPEVQKEIVTEEKIH--------------------------VAISKRVEPPPK 9287
Query: 486 PPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRERE 545
P P +P P P P KV K+P EV KK E K + +K+
Sbjct: 9288 VPELPEKPAPEEVAPVPIP-KKVEPPAPKVP---EVPKKPVPEEKKPVPVPKKE------ 9337
Query: 546 KDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLK 605
K E K+ E K P K++EA P K +++
Sbjct: 9338 ---------PAAPPKVPEVPKKPVPEEKIP-VPVAKKKEAPPAKVP-----------EVQ 9376
Query: 606 DGLVRKEK-------EKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPA-PPLVLP 657
G+V +EK E+ KK ++R+ K++ K PA P +P
Sbjct: 9377 KGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVP 9436
Query: 658 PKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK---------EKEKKKDKKEK 708
+++A+P+ A + P S V+ EK F +EK+ + + ++E
Sbjct: 9437 EEKVAVPV-PVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEW 9495
Query: 709 KKKKEKE--------KEKKEKEREKEKREREKREKEKEKHKHEKIKV--EPVALAPSPVI 758
+E+E +E++E+E E E E E E+ +E EK+ + + V P+ V
Sbjct: 9496 SYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVT 9555
Query: 759 PRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLL 818
R + KIV+ +PA + + PPPA P +V VP P+
Sbjct: 9556 ERQ-------EKKIVLKPKIPA----------KIEEPPPAKVPEAPKKIVPEKKVPAPVP 9598
Query: 819 AQAAAGPALLPSPGPAASGASAKAPVRSVVTE 850
+ P +P P K P + + E
Sbjct: 9599 KKEKVPPPKVPEE-PKKPVPEKKVPPKVIKME 9629
Score = 52.8 bits (125), Expect = 2e-06
Identities = 136/652 (20%), Positives = 222/652 (34%), Gaps = 116/652 (17%)
Query: 219 INTQKIPPMLSPVHVQDST--------DLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTP 270
+ T++I L P + DS PP PP++AP +PT E K P
Sbjct: 8923 LTTKEIKLELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTP---EEKKPPP 8979
Query: 271 KTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHI 330
K T +K + K V+K K+ R + K P P TT I
Sbjct: 8980 KRIEVTKKAVKKD-----------------AKKVVAKPKEMTPREEIVKKPPPP--TTLI 9020
Query: 331 PQTPVRPETPNRTPSATLSEKISKETI-QVKQIQTPPDAGKLNSENQPKKAVVADKTIEA 389
P + P ++ +E++ TI + K++Q +A + K+ V ++ E
Sbjct: 9021 P-----AKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEE 9075
Query: 390 SIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGST 449
D + E P+ + E +I K+ + + G
Sbjct: 9076 PYDELEVEPYTEPFEQPY-YEEPDEDYEEIKVEAKK---------EVHEEWEEDFEEGQE 9125
Query: 450 PLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVY 509
G + W EV++ K + P +PP P+ + K
Sbjct: 9126 YYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPV 9185
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETG 569
EK + S +M++++ Q + E K K ++ + +E+ E
Sbjct: 9186 IEKIEKTS-------------RRMEEEKVQVTKVPEVSK-KIVPQKPSRTPVQEEVIEVK 9231
Query: 570 RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKD 629
+ K + EE+ +E P+V+ + + E++ H K E K
Sbjct: 9232 VPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKE---IVTEEKIHVAISKRVEPPPKV 9288
Query: 630 KDKREK---EKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLP 686
+ EK E+V K++ PAP + PK+ P + P +P P P
Sbjct: 9289 PELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKK-------PVPEEKKPVPVPKKEPAAP 9341
Query: 687 EKLFEEKEKVKEKEK----KKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKH 742
K+ E +K +EK KKE K E +K EK ++ E
Sbjct: 9342 PKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREE-------- 9393
Query: 743 EKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPP-APAP 801
+P P +P + K VP E KP P + PPP PA
Sbjct: 9394 ----------SPPPAVPEIP------------KKKVP-EERKPVPRKEEEVPPPPKVPAL 9430
Query: 802 APGPMLVSPAPVPLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVS 853
P+ VP+P+ +A P P S + R V E +S
Sbjct: 9431 PKKPVPEEKVAVPVPVAKKA-------PPPRAEVSKKTVVEEKRFVAEEKLS 9475
Score = 39.7 bits (91), Expect = 0.013
Identities = 97/480 (20%), Positives = 179/480 (37%), Gaps = 57/480 (11%)
Query: 187 EELPAMKRPRLLST-----KGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAP 241
EE+PA K ++ST T +EA SI T ++ + +
Sbjct: 197 EEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMV-------IDGAAGQQL 249
Query: 242 PSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRS 301
P PP + P KS+ PT + K+ + ++ SP + + SP A SP+RS
Sbjct: 250 PHKTPPRIPPKPKSRSPTPPSIAAKA--QLARQQSPSPIRHSPSP-VRHVRAPTPSPVRS 306
Query: 302 PKTVSKEKKSPGRS-KSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVK 360
++ SP RS +SP + + +T V P A+ SE +ET
Sbjct: 307 VSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVASSSEAEMRETTLTT 366
Query: 361 QIQTPPD---AGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEG 417
Q + G+ + Q + A AS+ A + A E ++
Sbjct: 367 STQIRTEERWEGRYGVQEQVTISGAAGAA--ASVSASASYAAEAVATGAKEVKQDADKSA 424
Query: 418 DIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKA 477
+ T + P S ++ +T + + ++ +VV A
Sbjct: 425 AVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKE-AEKTAVTKVVVAA 483
Query: 478 KLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYE------EKTKLPSSVEVKKKLKKE--- 528
+ + V E +H +E EKT +P V K K++
Sbjct: 484 DKAKEQELKSR-----TKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQETR 538
Query: 529 LKTKMKKKEKQRDREREKDKNK-----------DKSKEKDKVKEKEKDKETGRETKY-PW 576
+ ++ KK+KQ +E + + + KS + + V +++ T ++ + +
Sbjct: 539 ISEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSY 598
Query: 577 KEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKE----KHKDKKKDREKGKKDKDK 632
++ +KE K + + PKVK +D LV + +E K + + +EK +K+ +K
Sbjct: 599 EKIMKETR----KTVVPKVIVATPKVKEQD-LVSRGREGITTKREQVQITQEKMRKEAEK 653
Score = 33.1 bits (74), Expect = 1.2
Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 11/122 (9%)
Query: 275 KTSSPGQKTKSPKTAQSPAMVGSPIRS-PKTVS-KEKKSPGRSKSPKSPKS--PKVTTHI 330
+ SP + KSP+ +SP V SP S PK VS E K K P S PK+T +
Sbjct: 32665 RVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFL 32724
Query: 331 PQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEAS 390
+ A L+ + ++ K++ D KL + AD T E
Sbjct: 32725 -------KAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELK 32777
Query: 391 ID 392
I+
Sbjct: 32778 IN 32779
Score = 32.3 bits (72), Expect = 2.1
Identities = 62/245 (25%), Positives = 98/245 (40%), Gaps = 17/245 (6%)
Query: 506 HKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKD 565
+K + T V+ +K L +E + +K QR E E+ ++ V +K+
Sbjct: 1781 NKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTG---VTTDQKE 1837
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVK--LKDGLVRKEKEKHKDKKKDR 623
K+ YP E ++ E + +F+ + PKV L L+RK K + + R
Sbjct: 1838 KQKPDIVLYP--EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK-----RFRVR 1890
Query: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPK---ELALPLFSPATASRVPAMLPS 680
G D + K D G E K+ A P V+ K E+ + R P P
Sbjct: 1891 YDGIHYLDIVDC-KSYDTG-EVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPE 1948
Query: 681 LLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKH 740
P KL E +KV + KE K K E+ EK E+ + R K ++ E+
Sbjct: 1949 FHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEG 2008
Query: 741 KHEKI 745
+E I
Sbjct: 2009 YYEAI 2013
Score = 32.0 bits (71), Expect = 2.7
Identities = 40/139 (28%), Positives = 56/139 (40%), Gaps = 16/139 (11%)
Query: 712 KEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDK 771
+E+ KK K + E R+ EK K+E A S + + AGQ
Sbjct: 196 EEEVPAKKTKTIVSTAQISESRQTRIEK------KIEAHFDARSIATVEMVIDGAAGQQ- 248
Query: 772 IVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPV---PLPLLAQAAAGPALL 828
+ P P P P P TPP A A SP+P+ P P+ A P+ +
Sbjct: 249 --LPHKTP-PRIPPKPKSRSP-TPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPV 304
Query: 829 PSPGPAASGASAKAPVRSV 847
S PAA + +P+RSV
Sbjct: 305 RSVSPAA--RISTSPIRSV 321
Score = 31.6 bits (70), Expect = 3.6
Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 23/119 (19%)
Query: 687 EKLFEEKEKVKEKEKKKDKK-----------EKKKKKEKEKEKKEKERE------KEKRE 729
EK+ EE E+++ K K++ ++ + +KK E +E K ++ KE E
Sbjct: 1988 EKVPEESEELRSKFKRRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTE 2047
Query: 730 REKREKEKE------KHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPE 782
EK+ +E K +KI++ P AP + VG G D +VV P+
Sbjct: 2048 EEKKALAEEGKITIPTFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPD 2106
Score = 31.6 bits (70), Expect = 3.6
Identities = 25/103 (24%), Positives = 45/103 (43%), Gaps = 10/103 (9%)
Query: 705 KKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVA---LAPSPVIPRL 761
K E ++EK +K+ R++E E + E+E E KH + + A L +
Sbjct: 32219 KSELDFMSKEEKSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRRRSLSPT 32278
Query: 762 TLRVGAGQDKIVISKVVPAPE-------AKPAPSQNRPKTPPP 797
+ + +++ S+ PA E P P + RP++P P
Sbjct: 32279 YIELMRPVSELIRSRPQPAEEYEDDTERRSPTPERTRPRSPSP 32321
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 101 bits (252), Expect = 3e-21
Identities = 153/621 (24%), Positives = 250/621 (40%), Gaps = 94/621 (15%)
Query: 177 GKRPLDSPEAEELPAM-KRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQD 235
G+RP+D E EEL + KR LS ++ S Q + P ++
Sbjct: 261 GERPVDVAETEELELLLKREVPLSDDDESYT----------DSEEAQSVNPSSVDENIDS 310
Query: 236 STDLAPPSPEPPMLAPVAKSQMPTA---------------KPLETKSFTPKTKTKTSSPG 280
T+ E + P +K+ +P+A K ++ + K + K + P
Sbjct: 311 ETEKDSLICESKQILP-SKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 369
Query: 281 QKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-------SKSPKSPKSPKVTTHIPQT 333
+ Q A PK+ +K+ P R S ++ ++ K++T
Sbjct: 370 AEKTHLFAKQEKAFY------PKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST---SC 420
Query: 334 PVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAV--------VADK 385
V PET N +S E Q +++ N ENQ K + +
Sbjct: 421 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 480
Query: 386 TIEASIDAVIARACAE--REPDPFE--FSSGSESEGDIF-----TSPKRISG--PECTTP 434
T+ +D C+E RE F FS ++ +F SPK G + +TP
Sbjct: 481 TVNTGLD------CSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP 534
Query: 435 KASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISS 494
GS+ + L DN+ + V+ K S +F
Sbjct: 535 LKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG 594
Query: 495 PSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSK 554
+ + H E + KK+ KE KT K K K ++RE+EK K K+
Sbjct: 595 EKSNAKIKDEDHSPTFENSDC-----TLKKMDKEGKTLKKHKLKHKEREKEKHK-KEIEG 648
Query: 555 EKDKVKEKEKDKETGRETKYP---WKE-FLKEEEADPYKFKIK-EFEDVDPKVKLKDGLV 609
EK+K K K+ KE R ++ WKE F K +E + ++ E ++ K KL+ +
Sbjct: 649 EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 708
Query: 610 RKEKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSP 668
+ K K K+R K ++DK K+E EK RE+K+K L + + S
Sbjct: 709 DDKSTKEKHVSKERNFKEERDKIKKESEK---SFREEKIK----DLKEERENIPTDKDSE 761
Query: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREK-EK 727
T+ + A+ S+ L EK ++ ++++K KE K+K EK + KEK+ EK E+
Sbjct: 762 FTSLGMSAIEESIGLHLVEK------EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 815
Query: 728 REREKREKEKEKHKHEKIKVE 748
+ EK +K K +HK EK K++
Sbjct: 816 KTFEKEKKIKHEHKSEKDKLD 836
Score = 71.6 bits (174), Expect = 3e-12
Identities = 81/227 (35%), Positives = 111/227 (48%), Gaps = 40/227 (17%)
Query: 530 KTKMKKKEKQRDRER----EKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEA 585
K M+KK KQ D EK KNK+K +E DK KEK +DKE+ T + ++EE
Sbjct: 905 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITN---SKHIQEE-- 958
Query: 586 DPYKFKIKEFEDVDP-KVKLKDGLVRKEKEKHKDKKKD--REKGKKDKD---KREKEKVK 639
K+ VD K + + L KEK K + K +EK KKDKD +E++K K
Sbjct: 959 -------KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHK 1011
Query: 640 DKGRED---KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKV 696
DK + + K+K+ A PK P SPA+ P + L + FE +
Sbjct: 1012 DKIQINSLLKLKSEADK----PK----PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSL 1063
Query: 697 KEKEKKKDKKEKKKKKEKEKEK-KEKEREKEKREREKREKEKEKHKH 742
K+ E E+ KK KEK K KEKER + + E + K+KEK KH
Sbjct: 1064 KDLEI-----EQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1105
Score = 70.1 bits (170), Expect = 9e-12
Identities = 78/268 (29%), Positives = 119/268 (44%), Gaps = 55/268 (20%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK-----DKSKEKDKV-- 559
K +EK + S ++ K K E KT K+K+ + + + EKDK DK KEKDK+
Sbjct: 793 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 852
Query: 560 -------KEKEKDKETGRETKYPWKEFLKEE----------EADPYKFKIKEFEDVDPKV 602
KE EK K T K +E +E+ E + + + KE ++ K
Sbjct: 853 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
Query: 603 KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV---KDKGREDKMKAP--------- 650
K D + EK K+K+KDRE KK+K R+KE + K +++ K+
Sbjct: 913 KQSDNSEYSKSEKGKNKEKDRELDKKEK-SRDKESINITNSKHIQEEKKSSIVDGNKAQH 971
Query: 651 APPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKE--- 707
PL L K PL +P + +K ++ ++ KE++K KDK +
Sbjct: 972 EKPLSLKEKTKDEPLKTPDGKEK-------------DKKDKDIDRYKERDKHKDKIQINS 1018
Query: 708 -KKKKKEKEKEK-KEKEREKEKREREKR 733
K K E +K K K K+ R +EKR
Sbjct: 1019 LLKLKSEADKPKPKSSPASKDTRPKEKR 1046
Score = 69.3 bits (168), Expect = 2e-11
Identities = 71/250 (28%), Positives = 123/250 (49%), Gaps = 40/250 (16%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK---DKSKEKDKVKEKEKDK 566
E+K+KL +K +K + TK K K+R+ + E+DK K +KS ++K+K+ ++++
Sbjct: 698 EKKSKL------EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 751
Query: 567 E---TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623
E T +++++ EE+ KE + + +K+ + EK + + K+KD
Sbjct: 752 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDI 810
Query: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
EK ++ ++EK K+K + + +K K V KE L+S T
Sbjct: 811 EKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKD-KLYSHHT------------- 855
Query: 684 VLPEKLFEEKEKVKEKE--KKKDKKEKKKKK---EKEKEKKEKER----EKEKREREKRE 734
EK +E EK K KK D +EK ++K + +KEK EKER KEK EK+
Sbjct: 856 ---EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 912
Query: 735 KEKEKHKHEK 744
K+ + ++ K
Sbjct: 913 KQSDNSEYSK 922
Score = 63.5 bits (153), Expect = 9e-10
Identities = 75/283 (26%), Positives = 116/283 (40%), Gaps = 36/283 (12%)
Query: 528 ELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADP 587
E + ++K+EK +EK + + + KEKD K + K E ++ K+ E +++
Sbjct: 780 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH-------EHKSEK 832
Query: 588 YKFKIKEFEDVDPKVKLKDGLVRKEKEK-HKDKKKDREKGK-KDKDKREKEKVKDKGRED 645
K + E D K+K KD L EK HK+ +K + K D REK + K + D
Sbjct: 833 DKLDLSECVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHD 889
Query: 646 KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK 705
K K P KE L + + KEK +E +KK+
Sbjct: 890 KEK--------PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 941
Query: 706 KEKK-----KKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE--PVALAPSPVI 758
++K+ K ++EKK + K + EK KEK K E +K I
Sbjct: 942 RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDI 1001
Query: 759 PRLTLRVGAGQDKIVISKVV--------PAPEAKPAPSQNRPK 793
R R +DKI I+ ++ P P++ PA RPK
Sbjct: 1002 DRYKER-DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1043
Score = 39.7 bits (91), Expect = 0.013
Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 14/221 (6%)
Query: 493 SSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK 552
SSP+ P+ V ++ + +S E LK + KK K++ +++EK++ +++
Sbjct: 1033 SSPASKDTRPKEKRLVNDDL--MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1090
Query: 553 SKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED--------VDPKVKL 604
+ + K+K+KEK K T E+K K E K K+ +D VD K +
Sbjct: 1091 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVM 1150
Query: 605 KDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK----MKAPAPPLVLPPKE 660
G + ++ E K R + ED + P PP+
Sbjct: 1151 TLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDF 1210
Query: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
+ S + S+ P + + P L E+ + + E+ K
Sbjct: 1211 MLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIK 1251
Score = 39.3 bits (90), Expect = 0.017
Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 29/169 (17%)
Query: 512 KTKLPSSVEVKKKLKKE-LKT----KMKKKEKQRDREREKDKNKDKSK-----------E 555
K + + +K+K K E LKT + KK+K DR +E+DK+KDK + +
Sbjct: 968 KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1027
Query: 556 KDKVKEKEKDKETG-----------RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604
K K K K+T +T + LK+ E + + K KE K +L
Sbjct: 1028 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1087
Query: 605 KDGLVRKEKEKHKDKKKDREKGKKDKD--KREKEKVKDKGREDKMKAPA 651
++ + K K K+K K K+K+ + + +V D ++K A
Sbjct: 1088 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1136
Score = 30.4 bits (67), Expect = 8.0
Identities = 28/118 (23%), Positives = 47/118 (39%), Gaps = 13/118 (11%)
Query: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEK---REREKREKEKEKHKHEKIK 746
+ + K++ + K+ KEK K K R +E+ E+E EK+K K + K
Sbjct: 37 YSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKK 96
Query: 747 VEPVA-LAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAP 803
PV+ L P+ R ++ + + A + P + N P PA P
Sbjct: 97 STPVSILFGYPLSER---------KQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTP 145
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 101 bits (252), Expect = 3e-21
Identities = 153/621 (24%), Positives = 250/621 (40%), Gaps = 94/621 (15%)
Query: 177 GKRPLDSPEAEELPAM-KRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQD 235
G+RP+D E EEL + KR LS ++ S Q + P ++
Sbjct: 284 GERPVDVAETEELELLLKREVPLSDDDESYT----------DSEEAQSVNPSSVDENIDS 333
Query: 236 STDLAPPSPEPPMLAPVAKSQMPTA---------------KPLETKSFTPKTKTKTSSPG 280
T+ E + P +K+ +P+A K ++ + K + K + P
Sbjct: 334 ETEKDSLICESKQILP-SKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKENEPE 392
Query: 281 QKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-------SKSPKSPKSPKVTTHIPQT 333
+ Q A PK+ +K+ P R S ++ ++ K++T
Sbjct: 393 AEKTHLFAKQEKAFY------PKSFKSKKQKPSRVLYSSTESSDEEALQNKKIST---SC 443
Query: 334 PVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAV--------VADK 385
V PET N +S E Q +++ N ENQ K + +
Sbjct: 444 SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNL 503
Query: 386 TIEASIDAVIARACAE--REPDPFE--FSSGSESEGDIF-----TSPKRISG--PECTTP 434
T+ +D C+E RE F FS ++ +F SPK G + +TP
Sbjct: 504 TVNTGLD------CSEKTREEGNFRKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTP 557
Query: 435 KASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISS 494
GS+ + L DN+ + V+ K S +F
Sbjct: 558 LKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFG 617
Query: 495 PSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSK 554
+ + H E + KK+ KE KT K K K ++RE+EK K K+
Sbjct: 618 EKSNAKIKDEDHSPTFENSDC-----TLKKMDKEGKTLKKHKLKHKEREKEKHK-KEIEG 671
Query: 555 EKDKVKEKEKDKETGRETKYP---WKE-FLKEEEADPYKFKIK-EFEDVDPKVKLKDGLV 609
EK+K K K+ KE R ++ WKE F K +E + ++ E ++ K KL+ +
Sbjct: 672 EKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIK 731
Query: 610 RKEKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSP 668
+ K K K+R K ++DK K+E EK RE+K+K L + + S
Sbjct: 732 DDKSTKEKHVSKERNFKEERDKIKKESEK---SFREEKIK----DLKEERENIPTDKDSE 784
Query: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREK-EK 727
T+ + A+ S+ L EK ++ ++++K KE K+K EK + KEK+ EK E+
Sbjct: 785 FTSLGMSAIEESIGLHLVEK------EIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMER 838
Query: 728 REREKREKEKEKHKHEKIKVE 748
+ EK +K K +HK EK K++
Sbjct: 839 KTFEKEKKIKHEHKSEKDKLD 859
Score = 71.6 bits (174), Expect = 3e-12
Identities = 81/227 (35%), Positives = 111/227 (48%), Gaps = 40/227 (17%)
Query: 530 KTKMKKKEKQRDRER----EKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEA 585
K M+KK KQ D EK KNK+K +E DK KEK +DKE+ T + ++EE
Sbjct: 928 KHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDK-KEKSRDKESINITN---SKHIQEE-- 981
Query: 586 DPYKFKIKEFEDVDP-KVKLKDGLVRKEKEKHKDKKKD--REKGKKDKD---KREKEKVK 639
K+ VD K + + L KEK K + K +EK KKDKD +E++K K
Sbjct: 982 -------KKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHK 1034
Query: 640 DKGRED---KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKV 696
DK + + K+K+ A PK P SPA+ P + L + FE +
Sbjct: 1035 DKIQINSLLKLKSEADK----PK----PKSSPASKDTRPKEKRLVNDDLMQTSFERMLSL 1086
Query: 697 KEKEKKKDKKEKKKKKEKEKEK-KEKEREKEKREREKREKEKEKHKH 742
K+ E E+ KK KEK K KEKER + + E + K+KEK KH
Sbjct: 1087 KDLEI-----EQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKH 1128
Score = 70.1 bits (170), Expect = 9e-12
Identities = 78/268 (29%), Positives = 119/268 (44%), Gaps = 55/268 (20%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK-----DKSKEKDKV-- 559
K +EK + S ++ K K E KT K+K+ + + + EKDK DK KEKDK+
Sbjct: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYS 875
Query: 560 -------KEKEKDKETGRETKYPWKEFLKEE----------EADPYKFKIKEFEDVDPKV 602
KE EK K T K +E +E+ E + + + KE ++ K
Sbjct: 876 HHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
Query: 603 KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV---KDKGREDKMKAP--------- 650
K D + EK K+K+KDRE KK+K R+KE + K +++ K+
Sbjct: 936 KQSDNSEYSKSEKGKNKEKDRELDKKEK-SRDKESINITNSKHIQEEKKSSIVDGNKAQH 994
Query: 651 APPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKE--- 707
PL L K PL +P + +K ++ ++ KE++K KDK +
Sbjct: 995 EKPLSLKEKTKDEPLKTPDGKEK-------------DKKDKDIDRYKERDKHKDKIQINS 1041
Query: 708 -KKKKKEKEKEK-KEKEREKEKREREKR 733
K K E +K K K K+ R +EKR
Sbjct: 1042 LLKLKSEADKPKPKSSPASKDTRPKEKR 1069
Score = 69.3 bits (168), Expect = 2e-11
Identities = 71/250 (28%), Positives = 123/250 (49%), Gaps = 40/250 (16%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK---DKSKEKDKVKEKEKDK 566
E+K+KL +K +K + TK K K+R+ + E+DK K +KS ++K+K+ ++++
Sbjct: 721 EKKSKL------EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 774
Query: 567 E---TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623
E T +++++ EE+ KE + + +K+ + EK + + K+KD
Sbjct: 775 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEK-RSQIKEKDI 833
Query: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
EK ++ ++EK K+K + + +K K V KE L+S T
Sbjct: 834 EKMERKTFEKEK-KIKHEHKSEKDKLDLSECVDKIKEKD-KLYSHHT------------- 878
Query: 684 VLPEKLFEEKEKVKEKE--KKKDKKEKKKKK---EKEKEKKEKER----EKEKREREKRE 734
EK +E EK K KK D +EK ++K + +KEK EKER KEK EK+
Sbjct: 879 ---EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKN 935
Query: 735 KEKEKHKHEK 744
K+ + ++ K
Sbjct: 936 KQSDNSEYSK 945
Score = 63.5 bits (153), Expect = 9e-10
Identities = 75/283 (26%), Positives = 116/283 (40%), Gaps = 36/283 (12%)
Query: 528 ELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADP 587
E + ++K+EK +EK + + + KEKD K + K E ++ K+ E +++
Sbjct: 803 EKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKH-------EHKSEK 855
Query: 588 YKFKIKEFEDVDPKVKLKDGLVRKEKEK-HKDKKKDREKGK-KDKDKREKEKVKDKGRED 645
K + E D K+K KD L EK HK+ +K + K D REK + K + D
Sbjct: 856 DKLDLSECVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHD 912
Query: 646 KMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK 705
K K P KE L + + KEK +E +KK+
Sbjct: 913 KEK--------PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKS 964
Query: 706 KEKK-----KKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE--PVALAPSPVI 758
++K+ K ++EKK + K + EK KEK K E +K I
Sbjct: 965 RDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDI 1024
Query: 759 PRLTLRVGAGQDKIVISKVV--------PAPEAKPAPSQNRPK 793
R R +DKI I+ ++ P P++ PA RPK
Sbjct: 1025 DRYKER-DKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK 1066
Score = 39.7 bits (91), Expect = 0.013
Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 14/221 (6%)
Query: 493 SSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK 552
SSP+ P+ V ++ + +S E LK + KK K++ +++EK++ +++
Sbjct: 1056 SSPASKDTRPKEKRLVNDDL--MQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNR 1113
Query: 553 SKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED--------VDPKVKL 604
+ + K+K+KEK K T E+K K E K K+ +D VD K +
Sbjct: 1114 NCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVM 1173
Query: 605 KDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK----MKAPAPPLVLPPKE 660
G + ++ E K R + ED + P PP+
Sbjct: 1174 TLGKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDF 1233
Query: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
+ S + S+ P + + P L E+ + + E+ K
Sbjct: 1234 MLESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIK 1274
Score = 39.3 bits (90), Expect = 0.017
Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 29/169 (17%)
Query: 512 KTKLPSSVEVKKKLKKE-LKT----KMKKKEKQRDREREKDKNKDKSK-----------E 555
K + + +K+K K E LKT + KK+K DR +E+DK+KDK + +
Sbjct: 991 KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEAD 1050
Query: 556 KDKVKEKEKDKETG-----------RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604
K K K K+T +T + LK+ E + + K KE K +L
Sbjct: 1051 KPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERL 1110
Query: 605 KDGLVRKEKEKHKDKKKDREKGKKDKD--KREKEKVKDKGREDKMKAPA 651
++ + K K K+K K K+K+ + + +V D ++K A
Sbjct: 1111 RNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDA 1159
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 99.0 bits (245), Expect = 2e-20
Identities = 68/254 (26%), Positives = 139/254 (54%), Gaps = 48/254 (18%)
Query: 492 ISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKD 551
+S +S P +P + E + +E +K+ KKE +++ KK+ ++R++ R++++ K+
Sbjct: 20 VSCSHISKPCTQPGWQ--SEIREREREIETRKEGKKERESERKKERREREK-RKREREKE 76
Query: 552 KSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRK 611
+ +E+ K ++K + K+ RE K +E KE + K K K+ E + K+G R+
Sbjct: 77 RKRERGKKEKKGERKKEERERKKRRRE--KENKEGEEKEKRKKKEKKERGRTSKEGKERE 134
Query: 612 EKEKHK-DKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPAT 670
KE+ K +++K+RE+ K++++K E+E+ + K RE K
Sbjct: 135 RKEERKREERKERERKKEEREK-ERERKERKKRERK------------------------ 169
Query: 671 ASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKRER 730
++ E++E+ KEKE+K+ KK ++ +KE++KE++ KER + K+ER
Sbjct: 170 -----------------QVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKER 212
Query: 731 EKREKEKEKHKHEK 744
+K+E+ K++ + ++
Sbjct: 213 KKKEERKKERQKDR 226
Score = 76.6 bits (187), Expect = 1e-13
Identities = 54/210 (25%), Positives = 106/210 (50%), Gaps = 59/210 (28%)
Query: 540 RDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVD 599
R+RERE + K+ KE++ ++KE+ RE + +E KE + + K
Sbjct: 39 REREREIETRKEGKKERESERKKER-----REREKRKREREKERKRERGK---------- 83
Query: 600 PKVKLKDGLVRKEKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPP 658
K K G +KE+ + K +++++E K ++K+KR+K++ K++GR K
Sbjct: 84 ---KEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSK------------ 128
Query: 659 KELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEK 718
E E+++ +++E++K+++ KK+++EKE+E+
Sbjct: 129 ----------------------------EGKERERKEERKREERKERERKKEEREKERER 160
Query: 719 KEKEREKEKREREKREKEKEKHKHEKIKVE 748
KE+++ + K+ EK E+ KEK + E+ K E
Sbjct: 161 KERKKRERKQVGEKEEERKEKERKERKKRE 190
Score = 72.8 bits (177), Expect = 1e-12
Identities = 50/195 (25%), Positives = 98/195 (50%), Gaps = 64/195 (32%)
Query: 556 KDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEK 615
+ +++E+E++ ET +E K KE E++ + K+ R+++++
Sbjct: 35 QSEIREREREIETRKEGK-------KERESE----------------RKKERREREKRKR 71
Query: 616 HKDKKKDREKGKKDK--DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASR 673
++K++ RE+GKK+K +++++E+ + K R +K
Sbjct: 72 EREKERKRERGKKEKKGERKKEERERKKRRREK--------------------------- 104
Query: 674 VPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKR 733
K EEKEK K+KEKK+ + K+ KE+E++++ K E+++RER+K
Sbjct: 105 ------------ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 734 EKEKEKHKHEKIKVE 748
E+EKE+ + E+ K E
Sbjct: 153 EREKERERKERKKRE 167
Score = 65.9 bits (159), Expect = 2e-10
Identities = 37/125 (29%), Positives = 77/125 (61%), Gaps = 8/125 (6%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEF 579
E +K+ KKE K + + ++ ++RER++++ +++ KE+++ KE E++KE R+ +
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE-EREKERERKER------ 163
Query: 580 LKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVK 639
K+ E K +E ++ + K + K RKE++K +++K+ RE+ K+ K K E++K +
Sbjct: 164 -KKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKER 222
Query: 640 DKGRE 644
K R+
Sbjct: 223 QKDRQ 227
Score = 58.5 bits (140), Expect = 3e-08
Identities = 36/135 (26%), Positives = 81/135 (60%), Gaps = 11/135 (8%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQR---DREREKDKNKDKSKEKDKVKEKE 563
K E+K + +S E K++ +KE + + ++KE++R +RE+E+++ + K +E+ +V EKE
Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKE 175
Query: 564 KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK--- 620
++++ KE K E + K +E ++ + K + ++KE+ KD++
Sbjct: 176 EERKEKER-----KERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Query: 621 KDREKGKKDKDKREK 635
+++E+GK+++ +R+K
Sbjct: 231 REKERGKRERKERKK 245
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 98.2 bits (243), Expect = 3e-20
Identities = 70/227 (30%), Positives = 117/227 (51%), Gaps = 13/227 (5%)
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKN-KDKSKEKDKVKEKEKDKETGRETKYPWKEFL 580
K KK K++ ++K + R R+K K+ ++K KEK++VKEK+++KE RE KE
Sbjct: 352 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE-----KERE 406
Query: 581 KEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKD 640
KE+E K + KE E K K KD +E+E+ K+ +KDR+K K+ + +EKE+ KD
Sbjct: 407 KEKERGKNKDRDKEREKDREKDKEKD----REREREKEHEKDRDKEKEKEQDKEKEREKD 462
Query: 641 KGRE-DKMKAPAPPLVLPPKELALPLFSPATA--SRVPAMLPSLLPVLPEKLFEEKEKVK 697
+ +E D+ + PP+ S +++ R S K + K
Sbjct: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522
Query: 698 EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+ ++KK+KK++KE++ + +ERE+ R+ K K EK
Sbjct: 523 PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEK 569
Score = 77.8 bits (190), Expect = 4e-14
Identities = 69/289 (23%), Positives = 132/289 (45%), Gaps = 66/289 (22%)
Query: 475 RKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELK---- 530
R K+ +N P ++ + + E + +V E ++ + +++E + E K
Sbjct: 249 RPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRS 308
Query: 531 ---TKMKKKEKQRDREREK-DKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEAD 586
T+ K + + R K ++K +S+ ++ + ++KD+ R +K P K+ K E
Sbjct: 309 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRSKSRE-- 363
Query: 587 PYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK 646
+ K + K KD K KEK + K+KDREK ++ + +REKEK + K ++
Sbjct: 364 ----RRKSRSRSHSRDKRKDTR-EKIKEKERVKEKDREKEREREKEREKEKERGKNKD-- 416
Query: 647 MKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK- 705
+KE+ K++EK K+K
Sbjct: 417 --------------------------------------------RDKEREKDREKDKEKD 432
Query: 706 KEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAP 754
+E++++KE EK+ ++KE+EKE+ + ++REK++ K EK K + + P
Sbjct: 433 REREREKEHEKD-RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480
Score = 43.5 bits (101), Expect = 0.001
Identities = 72/356 (20%), Positives = 131/356 (36%), Gaps = 29/356 (8%)
Query: 230 PVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFT-----PKTKTKTSSPGQKTK 284
P+ + S + PE A + + + E +SF P++ G +++
Sbjct: 250 PLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSR 309
Query: 285 SPKTAQSPAMVGSPIRSPKTVSKEK-KSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRT 343
S ++S + S R ++ SK + +S RS+S + + + H ++ R +R+
Sbjct: 310 SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS 369
Query: 344 PSATLSE-KISKETIQVKQIQTPPDAGK-------LNSENQPKKAVVADKTIEASIDAVI 395
S + + K ++E I+ K+ D K E + K DK E +
Sbjct: 370 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 429
Query: 396 ARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSG 455
+ E E E + +R E K K TP P S
Sbjct: 430 EKDREREREKEHEKDRDKEKEKEQDKEKER----EKDRSKEIDEKRKKDKKSRTP-PRSY 484
Query: 456 GTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515
S S + + R+ + + S P I S P+P +K ++K +
Sbjct: 485 NASRRSRSSSRER------RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK--KDKKRE 536
Query: 516 PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRE 571
+ ++ ++E T M+K RD + + +KN KEK+ KE D +E
Sbjct: 537 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE--HNKEPDSSVSKE 590
Score = 38.5 bits (88), Expect = 0.029
Identities = 31/137 (22%), Positives = 53/137 (38%), Gaps = 15/137 (10%)
Query: 509 YEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKET 568
Y + SS +++ + ++ + K R+ + + +KDK +EKE+D +
Sbjct: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHIS 543
Query: 569 GRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLK---DGLVRKEKEKHKDKKKDREK 625
R E + K D D K KL+ L KE K D +E
Sbjct: 544 ER------------RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV 591
Query: 626 GKKDKDKREKEKVKDKG 642
KD + E+ K++ G
Sbjct: 592 DDKDAPRTEENKIQHNG 608
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 98.2 bits (243), Expect = 3e-20
Identities = 70/227 (30%), Positives = 117/227 (51%), Gaps = 13/227 (5%)
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKN-KDKSKEKDKVKEKEKDKETGRETKYPWKEFL 580
K KK K++ ++K + R R+K K+ ++K KEK++VKEK+++KE RE KE
Sbjct: 236 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE-----KERE 290
Query: 581 KEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKD 640
KE+E K + KE E K K KD +E+E+ K+ +KDR+K K+ + +EKE+ KD
Sbjct: 291 KEKERGKNKDRDKEREKDREKDKEKD----REREREKEHEKDRDKEKEKEQDKEKEREKD 346
Query: 641 KGRE-DKMKAPAPPLVLPPKELALPLFSPATA--SRVPAMLPSLLPVLPEKLFEEKEKVK 697
+ +E D+ + PP+ S +++ R S K + K
Sbjct: 347 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 406
Query: 698 EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+ ++KK+KK++KE++ + +ERE+ R+ K K EK
Sbjct: 407 PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEK 453
Score = 77.8 bits (190), Expect = 4e-14
Identities = 69/289 (23%), Positives = 132/289 (45%), Gaps = 66/289 (22%)
Query: 475 RKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELK---- 530
R K+ +N P ++ + + E + +V E ++ + +++E + E K
Sbjct: 133 RPLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRS 192
Query: 531 ---TKMKKKEKQRDREREK-DKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEAD 586
T+ K + + R K ++K +S+ ++ + ++KD+ R +K P K+ K E
Sbjct: 193 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR---RRSKSPHKKRSKSRE-- 247
Query: 587 PYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDK 646
+ K + K KD K KEK + K+KDREK ++ + +REKEK + K ++
Sbjct: 248 ----RRKSRSRSHSRDKRKDTR-EKIKEKERVKEKDREKEREREKEREKEKERGKNKD-- 300
Query: 647 MKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK- 705
+KE+ K++EK K+K
Sbjct: 301 --------------------------------------------RDKEREKDREKDKEKD 316
Query: 706 KEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAP 754
+E++++KE EK+ ++KE+EKE+ + ++REK++ K EK K + + P
Sbjct: 317 REREREKEHEKD-RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 364
Score = 43.5 bits (101), Expect = 0.001
Identities = 72/356 (20%), Positives = 131/356 (36%), Gaps = 29/356 (8%)
Query: 230 PVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFT-----PKTKTKTSSPGQKTK 284
P+ + S + PE A + + + E +SF P++ G +++
Sbjct: 134 PLKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSR 193
Query: 285 SPKTAQSPAMVGSPIRSPKTVSKEK-KSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRT 343
S ++S + S R ++ SK + +S RS+S + + + H ++ R +R+
Sbjct: 194 SHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRS 253
Query: 344 PSATLSE-KISKETIQVKQIQTPPDAGK-------LNSENQPKKAVVADKTIEASIDAVI 395
S + + K ++E I+ K+ D K E + K DK E +
Sbjct: 254 RSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDK 313
Query: 396 ARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSG 455
+ E E E + +R E K K TP P S
Sbjct: 314 EKDREREREKEHEKDRDKEKEKEQDKEKER----EKDRSKEIDEKRKKDKKSRTP-PRSY 368
Query: 456 GTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515
S S + + R+ + + S P I S P+P +K ++K +
Sbjct: 369 NASRRSRSSSRER------RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNK--KDKKRE 420
Query: 516 PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRE 571
+ ++ ++E T M+K RD + + +KN KEK+ KE D +E
Sbjct: 421 KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE--HNKEPDSSVSKE 474
Score = 38.5 bits (88), Expect = 0.029
Identities = 31/137 (22%), Positives = 53/137 (38%), Gaps = 15/137 (10%)
Query: 509 YEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKET 568
Y + SS +++ + ++ + K R+ + + +KDK +EKE+D +
Sbjct: 368 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHIS 427
Query: 569 GRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLK---DGLVRKEKEKHKDKKKDREK 625
R E + K D D K KL+ L KE K D +E
Sbjct: 428 ER------------RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV 475
Query: 626 GKKDKDKREKEKVKDKG 642
KD + E+ K++ G
Sbjct: 476 DDKDAPRTEENKIQHNG 492
>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
Length = 483
Score = 94.0 bits (232), Expect = 6e-19
Identities = 79/284 (27%), Positives = 139/284 (48%), Gaps = 60/284 (21%)
Query: 475 RKAKLGTPSNMPPNFPYISSPSVS----PPTPEPLHKVYEEK---------TKLPSSVEV 521
R K+GT + P ++ S + TPE L + E K T L S ++
Sbjct: 147 RDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKN 206
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
K+++++E + + +++E +R R+RE+++ K K +EK K K+ EK K+ R P ++ LK
Sbjct: 207 KQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR---IPERDKLK 263
Query: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKG-KKDKDKREKEKVKD 640
+E PK+K+ L++ +K+ KK EKG +K+ DKREK K D
Sbjct: 264 DE----------------PKIKVHRFLLQAVNQKNLLKKP--EKGDEKELDKREKAKKLD 305
Query: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700
K +A LP + +L +EK K E E
Sbjct: 306 KENLSDERASGQSCTLPKRS-------------------------DSELKDEKPKRPEDE 340
Query: 701 KKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+D +E++++ E+++E+ +ERE+ KR+ E+R ++KE+++ EK
Sbjct: 341 SGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEK 384
Score = 48.1 bits (113), Expect = 4e-05
Identities = 44/159 (27%), Positives = 79/159 (49%), Gaps = 25/159 (15%)
Query: 511 EKTKLPSSVEVKKKLKKELKTK--------------MKKKEKQRDRE---REKDKNKDKS 553
EK K + + KLK E K K +KK EK ++E REK K DK
Sbjct: 248 EKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
Query: 554 KEKDKVKEKEK---DKETGRETKYPWKEFLKEEEADPYKFKIKEFE-DVDPKVKLKDGLV 609
D+ + K + E K + ++E Y+ + +E+E D + ++ ++ L
Sbjct: 308 NLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLK 367
Query: 610 RKEKEKHKDKKK-DREKGKKDKD---KREKEKVKDKGRE 644
R+E+E+ + K++ ++EK K K+ K+EK+ ++DKG++
Sbjct: 368 RQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK 406
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/135 (22%), Positives = 66/135 (48%), Gaps = 9/135 (6%)
Query: 615 KHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRV 674
K K KK+D + G D D ++ ++ +++ P +L E +
Sbjct: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAK-------NRELI 193
Query: 675 PAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKRE 734
LL L K + + K +E+++ + E+K+++E+E+ K ++E ++++++ EK +
Sbjct: 194 AKKTTPLLSFLKNK--QRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLK 251
Query: 735 KEKEKHKHEKIKVEP 749
K + +K+K EP
Sbjct: 252 KIDRIPERDKLKDEP 266
Score = 43.1 bits (100), Expect = 0.001
Identities = 41/168 (24%), Positives = 74/168 (44%), Gaps = 26/168 (15%)
Query: 522 KKKLKKELKTKMKKKE---------------KQRDREREKDKNKDKSKEKDK-VKEKEKD 565
+K+L K K K KE K+ D E + +K K E + +E+E++
Sbjct: 292 EKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERERE 351
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREK 625
E +E +E LK +E + + + KE + + K K+ ++KEK+ +DK K E
Sbjct: 352 YERDQERILRERERLKRQEEE--RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAES 409
Query: 626 GKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASR 673
+ + EK ++ + D+++ P A+ L+ P SR
Sbjct: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRP--------AMQLYQPGARSR 449
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 91.3 bits (225), Expect = 4e-18
Identities = 62/225 (27%), Positives = 113/225 (50%), Gaps = 53/225 (23%)
Query: 526 KKELKTKMKKKEKQ-RDREREKDKNKDKSK-EKDKVKEKEKDKETGRETKYPWKEFLKEE 583
++E + K +++E++ R REREK++ +++ K EK K K++E+ KE R+ K K+ +
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 584 EADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGR 643
E + K K KEK+K + K++ R + KK K+++E+E+ + R
Sbjct: 91 EKERRKRK-------------------KEKKKRERKQRGRRERKKKKERKERERENKQRR 131
Query: 644 EDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKK 703
E K K + ++EK + K ++K
Sbjct: 132 ERKRKKRRKK--------------------------------KRRKERKREKERGKRERK 159
Query: 704 DKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE 748
KK KK+++EK++E+ KER+KE+ +E+RE++KE+ K + K E
Sbjct: 160 RKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKE 204
Score = 88.6 bits (218), Expect = 2e-17
Identities = 60/224 (26%), Positives = 115/224 (51%), Gaps = 50/224 (22%)
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
+KK ++E + + +++EK+R RER K K K K K++++ KE+E+ + +E + KE +
Sbjct: 36 RKKERREREKRKREREKERKRERGK-KEKKKRKKRERGKERERKR---KEREKQRKERRE 91
Query: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDK 641
+E K K K + + K RKE+E+ ++++R++ K+ K KR KE+ ++K
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 642 GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
R + E+++ K K++
Sbjct: 152 ERGKR---------------------------------------------ERKRKKRKKE 166
Query: 702 KKDKKEKKKKKEKEKEKKEKEREKEKREREK-REKEKEKHKHEK 744
+++KK ++ +KE++KE++ KER + K+ER+K R K+KE+ K K
Sbjct: 167 EREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRK 210
Score = 87.0 bits (214), Expect = 7e-17
Identities = 56/230 (24%), Positives = 122/230 (53%), Gaps = 57/230 (24%)
Query: 517 SSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPW 576
++V++ +L+ + + K QR+ ER+K++ + + +++++ EKE+ +E G++ K
Sbjct: 9 AAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKRER--EKERKRERGKKEK--- 63
Query: 577 KEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKE 636
K+ K E + K KE E K R+EKE+ K KK+ +++ +K + +RE++
Sbjct: 64 KKRKKRERGKERERKRKERE--------KQRKERREKERRKRKKEKKKRERKQRGRRERK 115
Query: 637 KVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKV 696
K K++ ++ E K++
Sbjct: 116 KKKERKERER--------------------------------------------ENKQRR 131
Query: 697 KEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
+ K KK+ KK+++K++++EKE+ ++ER+++KR++E+REK++E+++ E+ K
Sbjct: 132 ERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKK 181
Score = 78.2 bits (191), Expect = 3e-14
Identities = 61/247 (24%), Positives = 121/247 (48%), Gaps = 45/247 (18%)
Query: 492 ISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKD 551
+S +S P + + E K + + K++ +KE K + KKEK++ ++RE+ K ++
Sbjct: 20 VSCSHISKPCTQ---RESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERE 76
Query: 552 -KSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFK--IKEFEDVDPKVKLKDGL 608
K KE++K +++ ++KE + K K K+ K K KE E + + + +
Sbjct: 77 RKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRK 136
Query: 609 VRKEKEKHKDKKKDREKGKKD-KDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFS 667
R++K++ K++K+++E+GK++ K K+ K++ ++K RE K
Sbjct: 137 KRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK------------------- 177
Query: 668 PATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEK 727
E+ E + K + + KK+ KKE++KKKE++K++K + +
Sbjct: 178 -------------------ERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Query: 728 REREKRE 734
R RE
Sbjct: 219 VFRPLRE 225
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/77 (35%), Positives = 50/77 (64%), Gaps = 1/77 (1%)
Query: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEK-KKKKEKEKEKKEKEREKEK 727
A +SR L + L ++ + +E E+KK+++E+ K+K+E+EKE+K + +KEK
Sbjct: 4 AISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEK 63
Query: 728 REREKREKEKEKHKHEK 744
++R+KRE+ KE+ + K
Sbjct: 64 KKRKKRERGKERERKRK 80
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 88.2 bits (217), Expect = 3e-17
Identities = 51/251 (20%), Positives = 132/251 (52%), Gaps = 18/251 (7%)
Query: 511 EKTKLPSSVEVKKKLKKELKTKMKK---KEKQRDREREKDKNKDKSKEKDKVKEKEKDKE 567
EK + + K++ ++E K+ +E+QRDRE+E+++ D+ +++ + KE+ + KE
Sbjct: 67 EKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKE 126
Query: 568 TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGK 627
RET+ E ++ + D + + ++ + + + D +++ E+++ K+++REK +
Sbjct: 127 RERETERE-GERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNR 185
Query: 628 KDKDKREKEKVK---------DKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAML 678
+++ +RE+++ K ++GRE + + ++ R
Sbjct: 186 QERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQ 245
Query: 679 PSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKK-----EKEREKEKREREKR 733
+ +KE+ +E+++ +D+ ++K++E++ ++K E++RE E++ +R
Sbjct: 246 AERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQR 305
Query: 734 EKEKEKHKHEK 744
E+E+E+ ++ K
Sbjct: 306 ERERERERNRK 316
Score = 82.4 bits (202), Expect = 2e-15
Identities = 50/235 (21%), Positives = 131/235 (55%), Gaps = 13/235 (5%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYP-WKE 578
E ++ ++E + + ++ E++ DR+RE+ + KD+ +++D+ +E+++D+E RE + ++
Sbjct: 55 ERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERD 114
Query: 579 FLKEEEADPYKFKIKEFEDVDPKVKLK--DGLVRKEK----EKHKDKKKDREKGKKDKDK 632
+E+E + K + +E E + + + DG +E+ EK ++++ DRE+ ++ +
Sbjct: 115 RQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERN 174
Query: 633 REKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEE 692
R+KE+ ++K R+++ + + S R + E
Sbjct: 175 RQKEREREKNRQERRERERQ---REKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Query: 693 KEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEK---REREKREKEKEKHKHEK 744
+++ ++ E++++K+ ++++ + + +++KERE+E+ R+R++R+KE+E+ K
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRK 286
Score = 79.3 bits (194), Expect = 1e-14
Identities = 46/243 (18%), Positives = 126/243 (51%), Gaps = 50/243 (20%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDK-NKDKSKEKDKVKEKEKD 565
K E +T + ++ +KE + + K ++++R+RER+++K NK + + ++ +E+E++
Sbjct: 157 KERERQTDRERQRQTERNRQKE-REREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREK 625
+ET ET+ ++ + D + + ++ E K ++ +E E+ K+++++R++
Sbjct: 216 RETETETE-------RKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDR 268
Query: 626 GKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVL 685
+D+D+R+KE+ + R+ + +
Sbjct: 269 -DRDRDRRQKERERQTDRKRQRRTE----------------------------------- 292
Query: 686 PEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKI 745
++E +++E++++++ ++++ K + ++E+ERE+E++ +R++EKE+ + K
Sbjct: 293 -----RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKR 347
Query: 746 KVE 748
+ E
Sbjct: 348 QTE 350
Score = 79.0 bits (193), Expect = 2e-14
Identities = 50/239 (20%), Positives = 127/239 (53%), Gaps = 34/239 (14%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETG 569
E + + + E K++ +E + + +K E++R+++ E+++ ++ E+DK +E+E+D++
Sbjct: 213 ERERETETETERKRQTDRE-RDRQRKTEREREKQAERERASERETERDKERERERDRDRD 271
Query: 570 RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKD 629
R+ + KE +E + D + + E + + + + +E+E+++ ++++RE+ ++
Sbjct: 272 RDRRQ--KE--RERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERER 327
Query: 630 KDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKL 689
+ +RE E+ ++K RE K K R M +
Sbjct: 328 ERQRETERDREKERERKRK------------------------RQTEMDRERNRQTGREG 363
Query: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEK-----KEKEREKEKREREKREKEKEKHKHE 743
+ E+ +E+E+++D++ ++++E+E+++ KE+ER+ EK +RE EK++ + +
Sbjct: 364 RRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREK 422
Score = 73.6 bits (179), Expect = 8e-13
Identities = 45/235 (19%), Positives = 125/235 (53%), Gaps = 53/235 (22%)
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
+++ +++ +T+ +K+E+QR+RERE+++N+ + +E+++ +E+E+ +ET R+ +
Sbjct: 288 QRRTERDRETE-RKRERQRERERERERNRKRERERERERERERQRETERD---------R 337
Query: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDK 641
E+E + + + E + + ++G + E+E+ +++++DR+ + ++++RE+++ +D+
Sbjct: 338 EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR-EREERERDRDRDR 396
Query: 642 GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
+E + + ++++ +E EK
Sbjct: 397 QKERERQTE----------------------------------------KDRDGQRETEK 416
Query: 702 KKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSP 756
++++ EK ++ E+ +E + +EREK+K RE++ ++ + K + + P P
Sbjct: 417 QRER-EKDRESERGRE-RGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPP 469
Score = 70.1 bits (170), Expect = 9e-12
Identities = 45/243 (18%), Positives = 119/243 (48%), Gaps = 40/243 (16%)
Query: 501 TPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVK 560
T K E + E K+ ++E + +Q++RER+ D+ + + E+D+
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297
Query: 561 EKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK 620
E++++++ RE + +E ++ E + + + +E +++E +D++
Sbjct: 298 ERKRERQRERERE---RERNRKRERERERERERE----------------RQRETERDRE 338
Query: 621 KDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPS 680
K+RE+ +K + + ++E+ + GRE + +A +E ++R
Sbjct: 339 KERERKRKRQTEMDRERNRQTGREGRRQA--------ERERERERERDRQSAR------- 383
Query: 681 LLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKH 740
E+ E+++ ++++K+++++ +K + + + +K++EREK++ RE+ +E+
Sbjct: 384 ------EREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRERE 437
Query: 741 KHE 743
K +
Sbjct: 438 KQK 440
Score = 65.9 bits (159), Expect = 2e-10
Identities = 38/204 (18%), Positives = 100/204 (49%), Gaps = 56/204 (27%)
Query: 541 DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP 600
DRER + K +++ +EK ++ ++ET R+ + + E D ++ + + E
Sbjct: 53 DRERNRQKERERRREK-----RQTERETDRKRE-------RRREKDRHRKRDRHRERQRD 100
Query: 601 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE 660
+ K ++ +E+++ ++K+++R+K ++ + +RE E+ +D+ + +
Sbjct: 101 REKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQ-------------- 146
Query: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE 720
E+E+ ++ EK+++++ ++++ + + ++
Sbjct: 147 ------------------------------RERERQRDAEKERERQTDRERQRQTERNRQ 176
Query: 721 KEREKEKREREKREKEKEKHKHEK 744
KERE+EK +E+RE+E+++ K K
Sbjct: 177 KEREREKNRQERRERERQREKENK 200
Score = 50.1 bits (118), Expect = 1e-05
Identities = 39/172 (22%), Positives = 87/172 (50%), Gaps = 35/172 (20%)
Query: 510 EEKTKLPSSVEVKKKLKKEL---KTKMKKKEKQRDREREKDKNKDKSKEKDKVKEK---- 562
+ +T+ E K++ ++E + + +K+E++R+RERE+++ ++ ++++K +E+
Sbjct: 288 QRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKR 347
Query: 563 ------EKDKETGRE-TKYPWKEFLKEEEADPYKFKIKEFEDVD-----------PKVKL 604
E++++TGRE + +E +E E D + +E + D K
Sbjct: 348 QTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKD 407
Query: 605 KDGLVRKEK--------EKHKDKKKDREKGKKDKDKREKEKVKDK--GREDK 646
+DG EK E + +++ RE+ K+ +R++E+ D+ GR+ K
Sbjct: 408 RDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 44.7 bits (104), Expect = 4e-04
Identities = 27/127 (21%), Positives = 71/127 (55%), Gaps = 13/127 (10%)
Query: 520 EVKKKLKKELKTKMKKKE---------KQRDREREKDKNKDKSKEKDKVKEKEKDKETGR 570
E +++ K++ +T+M ++ +Q +RERE+++ +D+ +++ +E+E+D++ R
Sbjct: 338 EKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARER-EERERDRDRDR 396
Query: 571 ETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK 630
+ + +E E++ D + K+ E + + +E+EK K +++DRE+ +
Sbjct: 397 QKE---RERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQ 453
Query: 631 DKREKEK 637
R++++
Sbjct: 454 AGRQRKR 460
Score = 40.8 bits (94), Expect = 0.006
Identities = 14/47 (29%), Positives = 31/47 (65%)
Query: 698 EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+ K D ++++ ++KE+E++ ++R+ E+ KRE+ +EK +H K
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRK 90
Score = 38.5 bits (88), Expect = 0.029
Identities = 12/54 (22%), Positives = 39/54 (72%), Gaps = 1/54 (1%)
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+++E+ ++KE+++ ++EK++ + + K+E+ REK++ + R +E+++ + ++
Sbjct: 52 DDRERNRQKERER-RREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE 104
Score = 38.5 bits (88), Expect = 0.029
Identities = 15/67 (22%), Positives = 42/67 (62%), Gaps = 9/67 (13%)
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEK---------KEKEREKEKREREKREKEKEKHK 741
+E+E+ +EK + + + ++K+++ +EK++ ++++REKE+ + RE+++++ K
Sbjct: 60 KERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREK 119
Query: 742 HEKIKVE 748
+ E
Sbjct: 120 ERNRQKE 126
Score = 38.1 bits (87), Expect = 0.038
Identities = 11/52 (21%), Positives = 36/52 (69%)
Query: 693 KEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
K+ + ++ +KE+++++EK + ++E +R++E+R + R +++++H+ +
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQ 98
Score = 33.9 bits (76), Expect = 0.72
Identities = 8/53 (15%), Positives = 35/53 (66%)
Query: 692 EKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+ K + + ++ ++K++++ +EK + E+E ++++ R ++++ +++ +H +
Sbjct: 44 QAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRE 96
>gi|12711674 UPF3 regulator of nonsense transcripts homolog B
isoform 2 [Homo sapiens]
Length = 470
Score = 87.8 bits (216), Expect = 4e-17
Identities = 75/283 (26%), Positives = 131/283 (46%), Gaps = 71/283 (25%)
Query: 475 RKAKLGTPSNMPPNFPYISSPSVS----PPTPEPLHKVYEEK---------TKLPSSVEV 521
R K+GT + P ++ S + TPE L + E K T L S ++
Sbjct: 147 RDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKN 206
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
K+++++E + + +++E +R R+RE+++ K K +EK K K+ EK K+ R P ++ LK
Sbjct: 207 KQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR---IPERDKLK 263
Query: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDK 641
+E PK+KL KK + +K+ DKREK K DK
Sbjct: 264 DE----------------PKIKLL--------------KKPEKGDEKELDKREKAKKLDK 293
Query: 642 GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
+A LP + +L +EK K E E
Sbjct: 294 ENLSDERASGQSCTLPKRS-------------------------DSELKDEKPKRPEDES 328
Query: 702 KKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+D +E++++ E+++E+ +ERE+ KR+ E+R ++KE+++ EK
Sbjct: 329 GRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEK 371
Score = 53.9 bits (128), Expect = 7e-07
Identities = 43/148 (29%), Positives = 83/148 (56%), Gaps = 16/148 (10%)
Query: 511 EKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEK------ 564
EK K + + KLK E K K+ KK ++ D E+E DK ++K+K+ DK ++
Sbjct: 248 EKLKKIDRIPERDKLKDEPKIKLLKKPEKGD-EKELDK-REKAKKLDKENLSDERASGQS 305
Query: 565 ---DKETGRETKYPWKEFLKEEEADPYKFKIKEFE-DVDPKVKLKDGLVRKEKEKHKDKK 620
K + E K + ++E Y+ + +E+E D + ++ ++ L R+E+E+ + K+
Sbjct: 306 CTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKE 365
Query: 621 K-DREKGKKDKD---KREKEKVKDKGRE 644
+ ++EK K K+ K+EK+ ++DKG++
Sbjct: 366 RYEKEKTFKRKEEEMKKEKDTLRDKGKK 393
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/135 (22%), Positives = 66/135 (48%), Gaps = 9/135 (6%)
Query: 615 KHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRV 674
K K KK+D + G D D ++ ++ +++ P +L E +
Sbjct: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAK-------NRELI 193
Query: 675 PAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKRE 734
LL L K + + K +E+++ + E+K+++E+E+ K ++E ++++++ EK +
Sbjct: 194 AKKTTPLLSFLKNK--QRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLK 251
Query: 735 KEKEKHKHEKIKVEP 749
K + +K+K EP
Sbjct: 252 KIDRIPERDKLKDEP 266
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 7e-17
Identities = 71/228 (31%), Positives = 122/228 (53%), Gaps = 40/228 (17%)
Query: 528 ELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADP 587
++KT +KK ++++RER+K ++++K+K + K+KEKE + ETG++ + KE ++ E +
Sbjct: 224 KIKTVAQKKAEKKERERKK-RDEEKAKLR-KLKEKE-ELETGKKDQSKQKESQRKFEEET 280
Query: 588 YKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKM 647
K K+ V P + K ++ ++ KK ++K KK +K EKEK K KG
Sbjct: 281 VKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKG----- 335
Query: 648 KAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKE 707
P+ A+ V AM +L KL EE+E+ K +E E
Sbjct: 336 --------------------PSKAT-VKAMQEALA-----KLKEEEERQKREE------E 363
Query: 708 KKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPS 755
++ K+ +E E K KE E+ ++E+ +R+K+KEK + E++K E L S
Sbjct: 364 ERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
Score = 85.1 bits (209), Expect = 3e-16
Identities = 57/214 (26%), Positives = 110/214 (51%), Gaps = 36/214 (16%)
Query: 524 KLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEE 583
K+K + K +KKE++R + E+ K KEK++++ +KD+ +E++ ++E
Sbjct: 224 KIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEE----- 278
Query: 584 EADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKD---KKKDREKGKKDKDKREKEKVKD 640
E V KV + G++ +EK + + D E KK KDK++K+ K+
Sbjct: 279 ------------ETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKE 326
Query: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700
+ ++K K P S AT + L L + EE+E++K E
Sbjct: 327 EKEKEKKKGP----------------SKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
Query: 701 KKKDKKEKKKKKEKEKEKKEKEREKEKREREKRE 734
+ + K++++++ E+EK +++K++EKE++ER K+E
Sbjct: 371 ELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404
Score = 72.4 bits (176), Expect = 2e-12
Identities = 74/305 (24%), Positives = 137/305 (44%), Gaps = 75/305 (24%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETG 569
EEK + P++ E + K+ K K KKK ++ ++E+EK K K+ K + K KE
Sbjct: 296 EEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEE 355
Query: 570 RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKD 629
K +EEE +IK E+++ K K ++ R E+EK +++KK +EK +K+
Sbjct: 356 ERQK-------REEEE-----RIKRLEELEAKRKEEE---RLEQEK-RERKKQKEKERKE 399
Query: 630 KDKREKEKVKDKGREDKMKAPAPPLVLPPKELALP----------LFSPATASRVPAMLP 679
+ K+E + + RE + +A A +L + + +P ++ ++P L
Sbjct: 400 RLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Query: 680 SLL--------------------------PVLPEK----------------LFEEKEKVK 697
S PV PE+ EE EKV+
Sbjct: 460 SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVE 519
Query: 698 E-------KEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPV 750
KE ++++E+++++E+++E +E+E E+ + E + ++E EK EK + +
Sbjct: 520 GNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTL 579
Query: 751 ALAPS 755
PS
Sbjct: 580 DKKPS 584
Score = 68.9 bits (167), Expect = 2e-11
Identities = 83/330 (25%), Positives = 137/330 (41%), Gaps = 97/330 (29%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRERE------------------------ 545
EEK KL E K++L+ K + K+KE QR E E
Sbjct: 245 EEKAKLRKLKE-KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPT 303
Query: 546 ----------KDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEF---LKEEEADPYK--- 589
K K+K K K + + KEKEK K + T +E LKEEE +
Sbjct: 304 AAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEE 363
Query: 590 FKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKA 649
+IK E+++ K K ++ R E+EK +++KK +EK +K++ K+E + + RE + +A
Sbjct: 364 ERIKRLEELEAKRKEEE---RLEQEK-RERKKQKEKERKERLKKEGKLLTKSQREARARA 419
Query: 650 PAPPLVLPPKELAL----------PLFSPATASRVPAMLPSL------------------ 681
A +L + + + P++ ++P L S
Sbjct: 420 EATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQG 479
Query: 682 --------LPVLPEK----------------LFEEKEKVKEKEKKKDKKEKKKKKEKEKE 717
PV PE+ EE EKV+ + + KE +++E+E+E
Sbjct: 480 VPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEE 539
Query: 718 KKEKEREKEKREREKREKEKEKHKHEKIKV 747
++E++ E E+ E E+ E E + E KV
Sbjct: 540 EEEEDEESEEEEEEEGESEGSEGDEEDEKV 569
Score = 50.8 bits (120), Expect = 6e-06
Identities = 67/267 (25%), Positives = 110/267 (41%), Gaps = 60/267 (22%)
Query: 533 MKKKEKQRDREREKD-----------KNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
M KK+K + + KD + +KE++ K K K K+ ++ + + LK
Sbjct: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
Query: 582 E-EEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK-DKREKEKVK 639
E EE IK + V +K +E+ KDKKK +KGKK D + E+++
Sbjct: 61 ELEELSLEAQGIKADRET---VAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE 117
Query: 640 DKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKE----- 694
DK + K K A P V E+ +++P +K +E
Sbjct: 118 DK--DSKSKKTAKPKV----EMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171
Query: 695 -KVKEKEK-----------------KKDKKEKKKKKE---------------KEKEKKEK 721
K+KE+ + +K +K+ +K K K K +K
Sbjct: 172 KKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231
Query: 722 EREKEKREREKREKEKEKHKHEKIKVE 748
+ EK++RER+KR++EK K + K K E
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEE 258
Score = 50.8 bits (120), Expect = 6e-06
Identities = 51/239 (21%), Positives = 105/239 (43%), Gaps = 43/239 (17%)
Query: 518 SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK 577
+V+ + ++E +K KKK+ Q+ +++ D N + E +KD ++ + K +
Sbjct: 80 AVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-------DKDSKSKKTAKPKVE 132
Query: 578 EFLKEEEADPYKFKIKEFEDVDPKVKLK-DGLVRKEKEKHKDKKKDR-----EKGKKDKD 631
+ ++ D + K+ + K K DG E K K++ R E G + +
Sbjct: 133 MYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDE 192
Query: 632 KREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFE 691
+ K + K +++K P P + ++ + F+
Sbjct: 193 FLQSRKGQKKNQKNK---PGPNIESGNED-------------------------DDASFK 224
Query: 692 EKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPV 750
K ++K +KK++ ++KK+++EK K K +EKE+ E K+++ K+K K + E V
Sbjct: 225 IKTVAQKKAEKKER--ERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV 281
Score = 49.7 bits (117), Expect = 1e-05
Identities = 132/616 (21%), Positives = 228/616 (37%), Gaps = 98/616 (15%)
Query: 235 DSTDLAPPSPEPPMLAPVAKSQMPTA--KPLET--KSFTPKTKTKTSSPGQK-------- 282
D D+ E + A K+ T KP E + FT K K K G+K
Sbjct: 54 DEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDS 113
Query: 283 -------TKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPV 335
+KS KTA+ + S +K K + K+ KS K +
Sbjct: 114 EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK-AKGKAQKSNKKWDGSEEDEDNSK 172
Query: 336 RPETPNRTPSATLSEKISKETIQVKQIQTPPDAGK----LNSENQPKKAVVADKTIEASI 391
+ + +R S+ S S E +Q ++ Q K + S N+ A KT+
Sbjct: 173 KIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKK 232
Query: 392 DAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGP-------ECTTPKASTSANNFT 444
R +R+ + + E E ++ T K S E T K+ + +
Sbjct: 233 AEKKERERKKRDEEKAKLRKLKEKE-ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291
Query: 445 KSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEP 504
S + + DN + + +K K G S + E
Sbjct: 292 IPASEEKAETPTAAEDDN----EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA 347
Query: 505 LHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEK 564
L K+ EE+ + E + K +EL+ K K++E+ +RE+ K K+K + KE+
Sbjct: 348 LAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKER-------KER 400
Query: 565 DKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDRE 624
K+ G+ +E EA K+ + + V+ V KD L +K K+K
Sbjct: 401 LKKEGKLLTKSQREARARAEAT---LKLLQAQGVE--VPSKDSLPKKRPIYEDKKRKKIP 455
Query: 625 KGKKDKDKREKEK------VKDKGREDKMKAPAPPLVLPPKELALP---------LFSPA 669
+ + K+ E + V ++G +K + P P V P +E + S
Sbjct: 456 QQLESKEVSESMELCAAVEVMEQGVPEKEETPPP--VEPEEEEDTEDAGLDDWEAMASDE 513
Query: 670 TASRVPAMLPSL-LPVLPEKLFEEKEKVKEKEKKKDKKEKKKK-------KEKEKEKKEK 721
+V + + PE+ EE+E+ +E E+ ++++E++ + +E EK EK
Sbjct: 514 ETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573
Query: 722 E------------------------REKEKREREKREKEKEKHKHEKIKVEPVALAPSPV 757
+ R KE+R +K ++ EK + E K +P+
Sbjct: 574 DSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPI 633
Query: 758 IPRLTLRVGAGQDKIV 773
I L V G+ KI+
Sbjct: 634 ICVLG-HVDTGKTKIL 648
Score = 30.8 bits (68), Expect = 6.1
Identities = 16/51 (31%), Positives = 29/51 (56%)
Query: 699 KEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEP 749
KE++ K + KKKKEK+K+ +++ ++ E E + K E + V+P
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKP 83
>gi|11225260 DNA topoisomerase I [Homo sapiens]
Length = 765
Score = 84.3 bits (207), Expect = 5e-16
Identities = 70/221 (31%), Positives = 105/221 (47%), Gaps = 53/221 (23%)
Query: 541 DREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDP 600
D + KDK+KD+ + + K +KEKD+E + + K+ K K K KE
Sbjct: 20 DSHKHKDKHKDR-EHRHKEHKKEKDREKSKHSNSEHKDSEK-------KHKEKE------ 65
Query: 601 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKG-----REDKMKAPAPPLV 655
K K KDG EKHKDK KDR DK+KR++EKV+ G +E + +PP +
Sbjct: 66 KTKHKDG----SSEKHKDKHKDR-----DKEKRKEEKVRASGDAKIKKEKENGFSSPPQI 116
Query: 656 ----------LPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK 705
+PPKE PL P + +K+K ++ KK+K
Sbjct: 117 KDEPEDDGYFVPPKEDIKPLKRPRDEDDADY---------------KPKKIKTEDTKKEK 161
Query: 706 KEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
K K +++E K KK K ++K+K+ E K+K+ K E+ K
Sbjct: 162 KRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQK 202
Score = 65.9 bits (159), Expect = 2e-10
Identities = 78/302 (25%), Positives = 123/302 (40%), Gaps = 61/302 (20%)
Query: 506 HKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEK--- 562
HK +++ K S K +K+ K K K K K E+ KDK+KD+ KEK K ++
Sbjct: 38 HKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRAS 97
Query: 563 -----EKDKETG--------------------RETKYPWKEFLKEEEADPYKFKIKEFED 597
+K+KE G +E P K E++AD YK K + ED
Sbjct: 98 GDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDAD-YKPKKIKTED 156
Query: 598 VDPKVKLK-----DGLVRKEKEKHKDKK-------------KDREKGKKDKDKREKEKVK 639
+ K K DG ++K K K KDKK ++ +K K +++R E +K
Sbjct: 157 TKKEKKRKLEEEEDGKLKKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIK 216
Query: 640 DKGREDKMKAPAPPLVLPPKEL------ALPLFSPATASRVPAMLPSLL-------PVLP 686
K E K APP P+ + + SP A V +L +
Sbjct: 217 WKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSP-KAEEVATFFAKMLDHEYTTKEIFR 275
Query: 687 EKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
+ F++ K E+K K + + K + + +++ K EK K K ++EK+
Sbjct: 276 KNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLL 335
Query: 747 VE 748
E
Sbjct: 336 KE 337
Score = 52.0 bits (123), Expect = 3e-06
Identities = 43/140 (30%), Positives = 60/140 (42%), Gaps = 41/140 (29%)
Query: 612 EKEKHKDKKKDRE-KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPAT 670
+ KHKDK KDRE + K+ K ++++EK K E K
Sbjct: 20 DSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDS---------------------- 57
Query: 671 ASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK-KEKKKKKEKEKEKKEKEREKEKRE 729
EK +EKEK K K+ +K K+K K ++KEK K+EK R
Sbjct: 58 ----------------EKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGD-A 100
Query: 730 REKREKEKEKHKHEKIKVEP 749
+ K+EKE +IK EP
Sbjct: 101 KIKKEKENGFSSPPQIKDEP 120
Score = 49.3 bits (116), Expect = 2e-05
Identities = 26/63 (41%), Positives = 36/63 (57%), Gaps = 3/63 (4%)
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK---HEKIKV 747
E + K +KEK ++K + + K+ EKK KE+EK K + EK K+KHK EK K
Sbjct: 32 EHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKE 91
Query: 748 EPV 750
E V
Sbjct: 92 EKV 94
Score = 47.4 bits (111), Expect = 6e-05
Identities = 22/55 (40%), Positives = 35/55 (63%), Gaps = 1/55 (1%)
Query: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEK-KEKEREKEKREREKREKEKEKHKHE 743
F + K K+K KD++ + K+ +KEK++ K K E ++ EK+ KEKEK KH+
Sbjct: 16 FRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHK 70
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 84.0 bits (206), Expect = 6e-16
Identities = 103/385 (26%), Positives = 154/385 (40%), Gaps = 51/385 (13%)
Query: 406 PFEFSSGSESEGDIFTSPKRISGPECTT--PKASTSANNFTKSGSTPLPLSGGTSSSDNS 463
P S GS S+ D ++ + E + KA A++ T G++ SG S+
Sbjct: 1208 PSSSSIGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVK 1267
Query: 464 WTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPL--HKVYEEKTKLPSSVEV 521
E ++ K TP+ P P P K E K + P S +
Sbjct: 1268 ENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKE 1327
Query: 522 KKKLKKELKTKMKK-----------KEKQRDREREKDKNKDKSKE---KDKVKEKEKDKE 567
K+K KKE K K +K ++R+RE+E + +D +KE K+ VK EK
Sbjct: 1328 KEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPV 1387
Query: 568 TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHK---------- 617
+G + + E E + + KI +KD L+ ++ K
Sbjct: 1388 SGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPL 1447
Query: 618 DKKKDREKGKKDKDK-----REKEKVKDKGREDKMKAPA-------PPLVLPPKELALPL 665
K K+RE KKD DK RE+EK +K R+++ + + P L KE +
Sbjct: 1448 SKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTM 1507
Query: 666 FSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDK---KEKKKKKEKEKEKKEKE 722
S P P P + +EK K K K+K K +K K KKE
Sbjct: 1508 GVSKHKSESPCESP-----YPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESR 1562
Query: 723 REKEKRER-EKREKE--KEKHKHEK 744
+KEK E+ EKR+ KE+ KH K
Sbjct: 1563 HDKEKIEKKEKRDSSGGKEEKKHHK 1587
Score = 66.2 bits (160), Expect = 1e-10
Identities = 89/393 (22%), Positives = 156/393 (39%), Gaps = 63/393 (16%)
Query: 401 EREPDPFEFS---SGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGT 457
E+ PD + + SG + P+ + P+ + ++ G G
Sbjct: 1157 EKRPDLYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSA 1216
Query: 458 SSSDNSWTMDASID--------EVVRKAKLGTP--SNMPPNFPYISSPSVSPPTPEP-LH 506
S SD S T + + V KA TP ++ N S+ +V E
Sbjct: 1217 SKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKE 1276
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK 566
K E+K K P++ + L K+ KEK ++ KD+ ++KE+ +KEK+K
Sbjct: 1277 KEKEKKEKTPATTPEARVLGKD------GKEKPKEERPNKDEKARETKERTPKSDKEKEK 1330
Query: 567 ETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKG 626
F KEE+A KFK P + K +E+E+ K+ ++R+
Sbjct: 1331 ------------FKKEEKAKDEKFKTTV-----PNAESKS---TQEREREKEPSRERDIA 1370
Query: 627 KKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLF------SPATASRVPAMLPS 680
K+ K K + + +K+P P +P E SP+ +S V L
Sbjct: 1371 KEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIE 1430
Query: 681 L--------LPVLPEKLFEEKE---------KVKEKEKKKDKKEKKKKKEKEKEKKEKER 723
L + P L + KE K +E+ ++++KK++K +KE++++ +R
Sbjct: 1431 LKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDR 1490
Query: 724 EKEKREREKREKEKEKHKHEKIKVEPVALAPSP 756
E ++R++E K K E +P P
Sbjct: 1491 EVPPDLTKRRKEENGTMGVSKHKSESPCESPYP 1523
Score = 53.9 bits (128), Expect = 7e-07
Identities = 90/439 (20%), Positives = 162/439 (36%), Gaps = 53/439 (12%)
Query: 215 PLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKT 274
P + + + PP + VQ+ P S + +KS + + + +
Sbjct: 1182 PENEFHHKDPPPRNAVASVQNGPGGGPSSSS---IGSASKSDESSTEETDKSRERSQCGV 1238
Query: 275 KTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTP 334
K + T +PK S GS S K V + K G+ K + + TT P+
Sbjct: 1239 KAVNKASST-TPKGNSSNGNSGS--NSNKAVKENDKEKGKEKEKEKKEKTPATT--PEAR 1293
Query: 335 VRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAV 394
V + P E+ +K+ + + P + K E K+ D+ + ++
Sbjct: 1294 VLGKDGKEKPK---EERPNKDEKARETKERTPKSDK-EKEKFKKEEKAKDEKFKTTVPNA 1349
Query: 395 IARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLS 454
+++ ERE + P R E K S N TP+
Sbjct: 1350 ESKSTQEREREK---------------EPSR----ERDIAKEMKSKENVKGGEKTPV--- 1387
Query: 455 GGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTK 514
S S S + I E R+ K P SPS S + L ++ E K
Sbjct: 1388 ---SGSLKSPVPRSDIPEPEREQKRRKIDTHP-------SPSHSSTVKDSLIELKESSAK 1437
Query: 515 L-------PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKE 567
L P S ++++ K+ K +++ ++R+++ EKD+ + K + +E D
Sbjct: 1438 LYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNNDREVPPDLT 1497
Query: 568 TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR-EKG 626
R+ + K + P + +D + K K K K + K +K D+ G
Sbjct: 1498 KRRKEENGTMGVSKHKSESPCESPYPNEKDKE-KNKSKSSGKEKGSDSFKSEKMDKISSG 1556
Query: 627 KKDKDKREKEKVKDKGRED 645
K + + +KEK++ K + D
Sbjct: 1557 GKKESRHDKEKIEKKEKRD 1575
Score = 42.0 bits (97), Expect = 0.003
Identities = 45/151 (29%), Positives = 68/151 (45%), Gaps = 23/151 (15%)
Query: 613 KEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATAS 672
KE K+K K++EK KK+K + + G++ K K P P K+ + T
Sbjct: 1267 KENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEK---PKEERPNKDEK----ARETKE 1319
Query: 673 RVPAMLPSLLPVLPEKLFEEKEKV--KEKEKKKDKKEKKKKKEKEKEKKEKEREKE-KRE 729
R P K +EKEK +EK K + K E K +E+EREKE RE
Sbjct: 1320 RTP------------KSDKEKEKFKKEEKAKDEKFKTTVPNAE-SKSTQEREREKEPSRE 1366
Query: 730 REKREKEKEKHKHEKIKVEPVALAPSPVIPR 760
R+ ++ K K + + PV+ + +PR
Sbjct: 1367 RDIAKEMKSKENVKGGEKTPVSGSLKSPVPR 1397
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 84.0 bits (206), Expect = 6e-16
Identities = 79/281 (28%), Positives = 126/281 (44%), Gaps = 56/281 (19%)
Query: 490 PYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKN 549
P + ++ P P+ K +TKL + ++ LK K K ++ +E +
Sbjct: 514 PLATQKDLTGQVPTPVVK----QTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVT 569
Query: 550 KDKSKEKD-KVKEKEK-----DKETGRETK--YPWKEFLKEEEADPYKFKI--KEFEDVD 599
K EK KV+ KEK DK ETK KE +EE P K ++ K+ DV
Sbjct: 570 KVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVK 629
Query: 600 PKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPK 659
PK + + ++ K K +DKK+++EK KK+ K+E K P P K
Sbjct: 630 PKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKED------------KTPIKKEEKPKK 677
Query: 660 ELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKK----KKEKE 715
E E E K+++K++EKK+ KKE KK K+ K+
Sbjct: 678 E--------------------------EVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKK 711
Query: 716 KEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSP 756
+ KKE+++E +K E+E +++ K+ K K P++ A P
Sbjct: 712 EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKP 752
Score = 67.8 bits (164), Expect = 5e-11
Identities = 75/251 (29%), Positives = 112/251 (44%), Gaps = 26/251 (10%)
Query: 510 EEKTKLPSSVEVKKKLKKEL-----KTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEK 564
E K K E K+K KKE+ KT +KK+EK + E +K+ K+ KE+ K +KE
Sbjct: 641 ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEV 700
Query: 565 DKETG-----RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDK 619
KET +E K K+ +K+EE +P K +IK+ PK K E +K
Sbjct: 701 KKETPPKEVKKEVKKEEKKEVKKEEKEPKK-EIKKL----PKDAKKSSTPLSEAKKPAAL 755
Query: 620 K----KDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVP 675
K K E KKD K K K K + K + A V + A+ +
Sbjct: 756 KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIA 815
Query: 676 AMLPSL-------LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKR 728
A+ P+ L PE L ++ E++K +E K K + + E E+K KE E +
Sbjct: 816 AIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEA 875
Query: 729 EREKREKEKEK 739
++E+E K
Sbjct: 876 YVIQKEREVTK 886
Score = 66.2 bits (160), Expect = 1e-10
Identities = 65/257 (25%), Positives = 111/257 (43%), Gaps = 48/257 (18%)
Query: 469 SIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKE 528
S ++V+ K + P+ PS P+P ++ T + +K +KKE
Sbjct: 582 SKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKE 641
Query: 529 LKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPY 588
K K + K++++++ + K+ K + K K +EK K +E +E K KE KEE+ +P
Sbjct: 642 TKVKPEDKKEEKEKPK-KEVAKKEDKTPIKKEEKPKKEEVKKEVK---KEIKKEEKKEPK 697
Query: 589 KFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMK 648
K KE KE K+ KK+ +K K ++K K+++K ++ K
Sbjct: 698 KEVKKE---------------TPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKS 742
Query: 649 APAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEK 708
+ +P + ++ PA +L P +P+ KE+ KKD
Sbjct: 743 S-----------------TPLSEAKKPA---ALKPKVPK---------KEESVKKDSVAA 773
Query: 709 KKKKEKEKEKKEKEREK 725
K KEK K K K+ K
Sbjct: 774 GKPKEKGKIKVIKKEGK 790
Score = 54.7 bits (130), Expect = 4e-07
Identities = 141/731 (19%), Positives = 282/731 (38%), Gaps = 119/731 (16%)
Query: 53 SELYGRTDPILDDVGEA------FQLMGVSLHELEDYIHNIEPVTFPHQIPSFPV----S 102
++L + +P+ VG FQ MGV +LE Y+ N PV ++ F +
Sbjct: 389 NKLSMKPEPLFRSVGNTIDPVILFQKMGVG--KLEMYVLN--PVKSSKEMQYFMQQWTGT 444
Query: 103 KNNVLQFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEE--QVPTDGGTSAEAMQVPLEE 160
+ +F P ++ + Y+ IV E+ +V G ++ + LE+
Sbjct: 445 NKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEK 504
Query: 161 DDELE--EEEIINDENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSS 218
L+ ++ + ++ G+ P P +K+ +L + D+ + L A +PL S
Sbjct: 505 LKHLDFLKQPLATQKDLTGQVPT--------PVVKQTKL-KQRADSRES-LKPAAKPLPS 554
Query: 219 INTQK-----IPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTK 273
+ +K P + HV+ +PP + K + KP++T+ T +
Sbjct: 555 KSVRKESKEETPEVTKVNHVE----------KPPKVESKEKVMVKKDKPIKTE--TKPSV 602
Query: 274 TKTSSPGQKTKSPKTAQSPAMVGSPIR----SPKTVSKEKK-SPGRSKSPKSPKSPKVTT 328
T+ P ++ SP A+ + ++ KTV KE K P K K +V
Sbjct: 603 TEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAK 662
Query: 329 HIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIE 388
+TP++ E + + +++ KE + ++ + + K + KK V ++ E
Sbjct: 663 KEDKTPIKKE--EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKE 720
Query: 389 ASIDAVIARACAEREPDPFEFSSG--SESEGDIFTSPKRISGPECTTPKASTSANNFTKS 446
+ + ++ P + SS SE++ PK + E + K S +A +
Sbjct: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPK-VPKKEESVKKDSVAAGKPKEK 779
Query: 447 GSTPLPLSGG-----TSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPT 501
G + G +++ + A++ A +G + +SSP
Sbjct: 780 GKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSP------ 833
Query: 502 PEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKE 561
E L K +EE V+V K +K +L+ +++++ +E E + KE++ K
Sbjct: 834 -EDLTKDFEELKA--EEVDVTKDIKPQLELI---EDEEKLKETEPVEAYVIQKEREVTKG 887
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKD---GLVRKEKEKHKD 618
+ + G T E E E P + + E + VD K +D G + +
Sbjct: 888 PAESPDEGITTT----EGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYE 943
Query: 619 KKKDREKGKKDKDKREKEKVKDKGR------EDKMKAPAPPLVLPPKELALPLFSPATAS 672
+K + E+ ++ ++ E+ + E+ KA A +
Sbjct: 944 EKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIR---------------- 987
Query: 673 RVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREK 732
E++E V + + ++ + ++ E E+ E+E ++E + +
Sbjct: 988 ------------------EKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDA 1029
Query: 733 REKEKEKHKHE 743
RE+E E K E
Sbjct: 1030 REEEYEPEKME 1040
Score = 53.1 bits (126), Expect = 1e-06
Identities = 96/503 (19%), Positives = 186/503 (36%), Gaps = 52/503 (10%)
Query: 182 DSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLS-----SINTQKIP------PMLSP 230
++PE ++ +++P + +K + V+++ +P+ S+ +++P P+ +
Sbjct: 564 ETPEVTKVNHVEKPPKVESK----EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAE 619
Query: 231 VHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQ 290
V + +TD+ P + + + K + K + K K + +P +K + PK +
Sbjct: 620 VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE 679
Query: 291 SPAMVGSPIRS---------------PKTVSKEKKSPGRSKSPKSPKSPKVTTH-IPQTP 334
V I+ PK V KE K + + K K PK +P+
Sbjct: 680 VKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDA 739
Query: 335 VRPETP--NRTPSATLSEKISKETIQVKQIQT----PPDAGKLN---SENQPKKAVVADK 385
+ TP A L K+ K+ VK+ P + GK+ E + +AV A
Sbjct: 740 KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAV 799
Query: 386 TIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTK 445
A+ AV+A A E E+E + +SP+ ++ + + TK
Sbjct: 800 GTGATTAAVMAAAGIAAIGPAKEL----EAERSLMSSPEDLTKD---FEELKAEEVDVTK 852
Query: 446 SGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPL 505
L L + ++A + + R+ G + TPE L
Sbjct: 853 DIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEEL 912
Query: 506 HKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKD 565
V ++ E + +E +EK E E+ + +D + K
Sbjct: 913 EPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE-EDGEEHVCVSASKHSP 971
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREK 625
E K +++E+ + ED+D ++ + +E+ +DK +D +
Sbjct: 972 TEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDARE 1031
Query: 626 GKKDKDKREKE----KVKDKGRE 644
+ + +K E E V DK E
Sbjct: 1032 EEYEPEKMEAEDYVMAVVDKAAE 1054
Score = 52.0 bits (123), Expect = 3e-06
Identities = 124/610 (20%), Positives = 230/610 (37%), Gaps = 115/610 (18%)
Query: 190 PAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPML 249
PA K R+L G++ +LE E L ++ K P + DL P P +
Sbjct: 480 PAEKIIRVLFP-GNSTQYNILEGLEKLKHLDFLKQP-------LATQKDLTGQVPTPVVK 531
Query: 250 -------APVAKSQMPTAKPLETKSF-------------------TPKTKTKTSSPGQKT 283
A +S P AKPL +KS PK ++K +K
Sbjct: 532 QTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKD 591
Query: 284 KSPKTAQSPAMV---------GSPIRS----------------PKTVSKEKK-SPGRSKS 317
K KT P++ SP+++ KTV KE K P K
Sbjct: 592 KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKE 651
Query: 318 PKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQP 377
K +V +TP++ E + + +++ KE + ++ + + K +
Sbjct: 652 EKEKPKKEVAKKEDKTPIKKE--EKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEV 709
Query: 378 KKAVVADKTIEASIDAVIARACAEREPDPFEFSSG--SESEGDIFTSPKRISGPECTTPK 435
KK V ++ E + + ++ P + SS SE++ PK + E + K
Sbjct: 710 KKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPK-VPKKEESVKK 768
Query: 436 ASTSANNFTKSGSTPLPLSGG-----TSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFP 490
S +A + G + G +++ + A++ A +G +
Sbjct: 769 DSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERS 828
Query: 491 YISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNK 550
+SS PE L K +EE V+V K +K +L+ +++++ +E E +
Sbjct: 829 LMSS-------PEDLTKDFEELK--AEEVDVTKDIKPQLEL---IEDEEKLKETEPVEAY 876
Query: 551 DKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKD---G 607
KE++ K + + G T E E E P + + E + VD K +D G
Sbjct: 877 VIQKEREVTKGPAESPDEGITT----TEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAG 932
Query: 608 LVRKEKEKHKDKKKDREKGKKDKDKREK------EKVKDKGREDKMKAPAPPLVLPPKEL 661
+ ++K + E+ ++ ++ E+ K E+ KA A + +E
Sbjct: 933 FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRE- 991
Query: 662 ALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEK 721
S A+ ++ E+ ++ EK + + +E+ +++K ++ +E+
Sbjct: 992 -----SVASGD--------------DRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREE 1032
Query: 722 EREKEKRERE 731
E E EK E E
Sbjct: 1033 EYEPEKMEAE 1042
Score = 38.9 bits (89), Expect = 0.022
Identities = 82/416 (19%), Positives = 148/416 (35%), Gaps = 70/416 (16%)
Query: 116 DAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQV----PLEEDDELEEEEIIN 171
+ E E P+ L P V Q ++ E+ +G E+ + E +E EE E
Sbjct: 900 EGEGECEQTPEELEP-VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDG 958
Query: 172 DENFLGKRPLDSPEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPV 231
+E+ SP +E A D + E RE ++S + + M +
Sbjct: 959 EEHVCVSASKHSPTEDEESAKAEA----------DAYIREKRESVASGDDRAEEDMDEAI 1008
Query: 232 HVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQS 291
++ + E A A+ + + +E + + K + G + +
Sbjct: 1009 EKGEAEQSEEEADEEDK-AEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTT 1067
Query: 292 PAM---VGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATL 348
P SP R P + ++ PG S+S + + P+ T
Sbjct: 1068 PTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPE------------EFTA 1115
Query: 349 SEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFE 408
+ ++ TI++ TP D E + V++D+T E E E
Sbjct: 1116 TSGYTQSTIEISSEPTPMD------EMSTPRDVMSDETNNE-----------ETESPSQE 1158
Query: 409 FSSGSESEGDIFTSPKRISGPECTTP---------KASTSANNFTKSGSTPLPLSGGTSS 459
F + ++ E +++ + S P TP +T ++ S ST P S S
Sbjct: 1159 FVNITKYESSLYS--QEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPS---SM 1213
Query: 460 SDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISS--------PSVSPPTPEPLHK 507
++ ++ A D + K T ++ + +SS PS+SP P PL K
Sbjct: 1214 EEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEK 1269
Score = 38.1 bits (87), Expect = 0.038
Identities = 45/176 (25%), Positives = 69/176 (39%), Gaps = 22/176 (12%)
Query: 184 PEAEELPAMKRPRLLSTKGDTLDVVLLEAREPLSSINTQKI--PPMLSPVHVQDSTDLAP 241
PE EE P++ + ++ ++ + P T K PP P VQD + +P
Sbjct: 2164 PETEECPSITADANIDSEDESETI-------PTDKTVTYKHMDPP---PAPVQDRSP-SP 2212
Query: 242 PSPEPPMLAPVAKS-QMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIR 300
P+ M+ P A + + K L+ K KTKT PG KTKS + P+
Sbjct: 2213 RHPDVSMVDPEALAIEQNLGKALKKDL---KEKTKTKKPGTKTKSSSPVKKSDGKSKPLA 2269
Query: 301 SPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKET 356
+ + K+S + SPK + + PE A E+ KET
Sbjct: 2270 ASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEV-----KAARGEEKDKET 2320
Score = 34.3 bits (77), Expect = 0.55
Identities = 86/388 (22%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 295 VGSPIRSPKTVSK-----EKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLS 349
+G P S +T K E + S K+ ++P +T+ +T E RTP A+
Sbjct: 2001 LGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETA---EKITRTPQASTY 2057
Query: 350 EKISKETIQVKQIQTPPDAGK-------LNSENQPKKAVVADKTIEAS-IDAVIARACAE 401
+ + + ++P +A + + E + K ++ I + ++ + E
Sbjct: 2058 SYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTE 2117
Query: 402 REPDPFEFSSGSESEGDIFTSPKRISGPECT-TPKASTSANNFTKSGSTPLPLSGGTSSS 460
P S G+ + G +C TP S S + +++ S P +
Sbjct: 2118 ESEKPLTQSGGAPPPPG-----GKQQGRQCDETPPTSVSESAPSQTDSDVPP----ETEE 2168
Query: 461 DNSWTMDASID-----EVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515
S T DA+ID E + K T +M P + S SP P+ + V E +
Sbjct: 2169 CPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPD-VSMVDPEALAI 2227
Query: 516 PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKE------KEKDKETG 569
++ K LKK+LK K K K+ + K K K KE +
Sbjct: 2228 EQNLG--KALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVS 2285
Query: 570 RETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKD 629
R P K+ E+ A P P+VK G +EK K+ K
Sbjct: 2286 RVAS-PKKKESVEKAAKP---------TTTPEVKAARG-----EEKDKETK---NAANAS 2327
Query: 630 KDKREKEKVKDKGREDKMKAPAPPLVLP 657
K K G K+ A P LP
Sbjct: 2328 ASKSAKTATAGPGTTKTTKSSAVPPGLP 2355
Score = 31.2 bits (69), Expect = 4.7
Identities = 61/296 (20%), Positives = 109/296 (36%), Gaps = 45/296 (15%)
Query: 221 TQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPG 280
+ KIPPM P + QD+ L+ + A P + + TP ++ +SP
Sbjct: 1700 SHKIPPMEEPSYTQDND-----------LSELISVSQVEASPSTSSAHTP---SQIASPL 1745
Query: 281 QKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETP 340
Q+ A M + + T K + G SPKS S P TP R +P
Sbjct: 1746 QEDTLSDVAPPRDM---SLYASLTSEKVQSLEGEKLSPKSDIS-------PLTP-RESSP 1794
Query: 341 NRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACA 400
+P+ + S KE + P ++E +A V T++ +
Sbjct: 1795 LYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQHHL-----ALNR 1849
Query: 401 EREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSS 460
+ E SG ++ GD + ++ PE TT ++ T T +S
Sbjct: 1850 DLSTPGLEKDSGGKTPGDFSYAYQK---PEETTRSPDEEDYDYESYEKT-------TRTS 1899
Query: 461 DNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLP 516
D I+ + +PS+ ++ I + +P + +++ E+ T+ P
Sbjct: 1900 DVGGYYYEKIERTTK-----SPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTP 1950
Score = 30.8 bits (68), Expect = 6.1
Identities = 76/344 (22%), Positives = 121/344 (35%), Gaps = 53/344 (15%)
Query: 210 LEAREPLSSI--NTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKS 267
LE P S+ + P SP + S+ L E P PV+ E S
Sbjct: 1318 LEVVSPSQSVTGSAGHTPYYQSPTD-EKSSHLPTEVIEKPPAVPVSFEFSDAKDENERAS 1376
Query: 268 FTPKTKT--KTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGR-SKSPKSPKSP 324
+P + + SP +K SP +SP ++GS +S + K+ GR ++SP KS
Sbjct: 1377 VSPMDEPVPDSESPIEKVLSP--LRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSG 1434
Query: 325 KVTTHIPQTPVRPETP----------NRTPSATLSEKI--SKETIQVKQIQTPP------ 366
K + +PV T T A + E K+T V+ + + P
Sbjct: 1435 KQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDE 1494
Query: 367 -----------DAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSG--S 413
D + S + K +++ T+ + AE D + G S
Sbjct: 1495 RKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAE---DTYSHMEGVAS 1551
Query: 414 ESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEV 473
S + TS S PE TT S S + + GS T D+
Sbjct: 1552 VSTASVATS----SFPEPTTDDVSPSLH--AEVGS-----PHSTEVDDSLSVSVVQTPTT 1600
Query: 474 VRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPS 517
++ ++ P IS P SP T + V + +++ S
Sbjct: 1601 FQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSS 1644
Score = 30.8 bits (68), Expect = 6.1
Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 21/99 (21%)
Query: 630 KDKREKEKVKDKGREDKMKAP-------APPLVLPPKELALPLFSPATASRVPAMLPSLL 682
KD +EK K K G + K +P + PL PK L S SRV +
Sbjct: 2237 KDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLK-ESSDKVSRVAS------ 2289
Query: 683 PVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEK 721
P+K KE V++ K E K + +EK+K+ K
Sbjct: 2290 ---PKK----KESVEKAAKPTTTPEVKAARGEEKDKETK 2321
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 83.6 bits (205), Expect = 8e-16
Identities = 97/364 (26%), Positives = 155/364 (42%), Gaps = 76/364 (20%)
Query: 439 SANNFTKSGSTPLPLSGGTSSSDNSWT---MDASIDEVVRKAKLGTPSNMPPNFPYISSP 495
SA++ K GS PL L W D + + + + + I P
Sbjct: 77 SASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEP 136
Query: 496 SVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKE 555
P + +HK EK + P ++K++ ++ K K+K K++ RE+EK + K KE
Sbjct: 137 ---PLRKKEIHKDKTEKQEKP-----ERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKE 188
Query: 556 KDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEK 615
K + KEK + K +E K K + A+ + K K+ + K+K K KE
Sbjct: 189 KIEKKEKPETKTLAKEQK-------KAKTAEKSEEKTKKEVKGGKQEKVKQ-TAAKVKEV 240
Query: 616 HKDKKKDREKGKKDKDKREKEKVKDK-------------GREDKMKAPAPPLVLPPKELA 662
K K +EK K+K K + KD+ G ++PA P LP ++ +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300
Query: 663 LPLFSPATASRVPAMLPSLLPVLPEKLFEEK---EKVKEKEKKKDKKEKKKKKEKE---- 715
P +PA+ P L EK E+K +KV + KKK+K++ KKK EKE
Sbjct: 301 RP--TPAS------------PALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
Query: 716 ---KE--------------------KKEKEREKEKREREKREKEKEKHKHEKIKVEPVAL 752
KE KK++++E K+ ++ E E+ K K ++ K + V
Sbjct: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
Query: 753 APSP 756
A SP
Sbjct: 407 AKSP 410
Score = 71.6 bits (174), Expect = 3e-12
Identities = 78/329 (23%), Positives = 137/329 (41%), Gaps = 33/329 (10%)
Query: 494 SPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKS 553
SP++ PP P E+ P+ + K+ K K +KK +++EK+ K KS
Sbjct: 287 SPAIPPPLPT-------EQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKS 339
Query: 554 KEKDKVKEKEKDKETGRETKYPWKEFL------KEEEADPYKFKIKEFEDVDPKVKLKDG 607
+++ + ++K+ ETK + K+E+ + K K E PK G
Sbjct: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK-----G 394
Query: 608 LVRKEKEKHKDKKKDREK------GKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKEL 661
+++KEKH + K +K K+ K K E+ K + K P K +
Sbjct: 395 KKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTV 454
Query: 662 ALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEK 721
+ + + ++L P+ K EEK KEK+ + K+ +K + KE K K
Sbjct: 455 EQEI-RKEKSGKTSSILKDKEPI---KGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPK 510
Query: 722 EREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIV--ISKVVP 779
+ + ++ EK E + +K I + V P T+ G ++K++ + V
Sbjct: 511 PPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTI 570
Query: 780 APEAKPAP---SQNRPKTPPPAPAPAPGP 805
AKP P +++R + PP P P
Sbjct: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKP 599
Score = 66.6 bits (161), Expect = 1e-10
Identities = 110/510 (21%), Positives = 186/510 (36%), Gaps = 67/510 (13%)
Query: 262 PLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSP 321
PL K K P +K ++ T + +R + EKK+ + K K
Sbjct: 137 PLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKE--KPEKKATHKEKIEKKE 194
Query: 322 KSPKVTTHIPQTPVRP-----ETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQ 376
K T Q + E + EK+ + +VK++Q P K E++
Sbjct: 195 KPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK-EKEDK 253
Query: 377 PKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKA 436
K AV + D + F DIF G P
Sbjct: 254 EKAAV-----------------SKHEQKDQYAF---CRYMIDIFVHGDLKPGQSPAIPPP 293
Query: 437 STSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPS 496
T+ S P P S + + +V + K ++ ++
Sbjct: 294 LP-----TEQASRPTPASPALEEKEGE--KKKAEKKVTSETKKKEKEDIKKKSEKETAID 346
Query: 497 VSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEK 556
V P + + K+ + KK KKE K KK + + +K + K+K E
Sbjct: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406
Query: 557 DKVKEKE----KDKETGRETKYPWKEF--LKEEEADPYKFKIKEFEDVDPKVKL----KD 606
K +KE DK+ +T+ +E + ++A P K + K + V+ +++ K
Sbjct: 407 AKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKT 466
Query: 607 GLVRKEKE--KHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALP 664
+ K+KE K K++K +K+ + ++ EK+ G+E K P PP + KE
Sbjct: 467 SSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVK---PKPPQLQGKKE---- 519
Query: 665 LFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK-----KKDKKEKKKKKEKEKEKK 719
P + P + EK+ K+ + + EK K ++K K+ K EK
Sbjct: 520 ------EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKT 573
Query: 720 EKEREKEKREREKREKEKEKHKHEKIKVEP 749
K + +K E RE+E K +K K P
Sbjct: 574 AKPKPTKKAEH--REREPPSIKTDKPKPTP 601
Score = 55.1 bits (131), Expect = 3e-07
Identities = 60/232 (25%), Positives = 93/232 (40%), Gaps = 65/232 (28%)
Query: 596 EDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLV 655
ED D K ++ + +RK KE HKDK + +EK ++ + K K+KG+E + P
Sbjct: 126 EDTD-KGEIDEPPLRK-KEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKP--- 180
Query: 656 LPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKE 715
E+K KEK +KK+K E K +++
Sbjct: 181 -----------------------------------EKKATHKEKIEKKEKPETKTLAKEQ 205
Query: 716 KEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVIS 775
K+ K E+ +EK ++E + ++EK K KV+ V PS + ++K +S
Sbjct: 206 KKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKP------KEKEDKEKAAVS 259
Query: 776 K---------------VVPAPEAKPAPSQNRPKTPPPAPA-PAPGPMLVSPA 811
K + + KP S P PPP P A P SPA
Sbjct: 260 KHEQKDQYAFCRYMIDIFVHGDLKPGQS---PAIPPPLPTEQASRPTPASPA 308
Score = 40.4 bits (93), Expect = 0.008
Identities = 84/428 (19%), Positives = 152/428 (35%), Gaps = 68/428 (15%)
Query: 224 IPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPT-AKPLETKSFTPKTKTKTS----- 277
IPP L T +P E A+ ++ + K E + K++ +T+
Sbjct: 290 IPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEK 349
Query: 278 -SPGQKTKSPK-TAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQTPV 335
PG+ +++ + T + A + K SK+ K P + PK K K H+ +
Sbjct: 350 KEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV-EPAK 408
Query: 336 RPETPNRTPS----------------------ATLSEKISKETIQVKQIQTPPDAGKLNS 373
P+ + PS A +K K T V+Q +GK +S
Sbjct: 409 SPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSS 468
Query: 374 ENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTT 433
++ DK + + + E+EP+ + S++ ++ P ++ G
Sbjct: 469 -------ILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQG----- 516
Query: 434 PKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYIS 493
K P P + S + ++V+ K T S+ P +
Sbjct: 517 -----------KKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK--TVSHGKPEEKVLK 563
Query: 494 SPSV----SPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKN 549
P+P K E + + P S+ K K T E +++ + +
Sbjct: 564 QVKAVTIEKTAKPKPTKKA-EHREREPPSI----KTDKPKPTPKGTSEVTESGKKKTEIS 618
Query: 550 KDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLV 609
+ +SKEK +K ++K + R+ K E+ P + K+ EDV K K+G
Sbjct: 619 EKESKEKADMKHLREEKVSTRKESLQLHNVTKAEK--PARVS-KDVEDVPASKKAKEGTE 675
Query: 610 RKEKEKHK 617
K K
Sbjct: 676 DVSPTKQK 683
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 82.0 bits (201), Expect = 2e-15
Identities = 137/621 (22%), Positives = 223/621 (35%), Gaps = 103/621 (16%)
Query: 241 PPSPEPPML-APVAKSQMP-----TAKPLETK--------SFTPKTKTKTSSPGQKTKSP 286
PP P+PP AP P T +P++TK + TP T P P
Sbjct: 254 PPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEP 313
Query: 287 KTAQSPAMVGSPIRSPKTVSKEKKS-PGRSKSPKSPKSPKVTTHIPQ-TPVRPETPNRTP 344
KT + +G S + V KK P + P KS KV+ + + + E +
Sbjct: 314 KTTK----LGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKH 369
Query: 345 SA---TLSEKISKETIQVKQ----IQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIAR 397
+A + + E + + I+ P D + S+ + ++ A + A + + +
Sbjct: 370 AAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQE-FGADVRLMFSN 428
Query: 398 ACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGT 457
C + P E + + D+F E P + S+ P S
Sbjct: 429 -CYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSD 487
Query: 458 SSSDNSWTMDASID--EVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515
SSSD+S D+S D E R +L E L V+E+ L
Sbjct: 488 SSSDSSSDSDSSTDDSEEERAQRLAE-------------------LQEQLKAVHEQLAAL 528
Query: 516 PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYP 575
+ K K KKE K KKKEK + +E ++ K K+KE K K+ + +K
Sbjct: 529 SQPQQNKPK-KKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSK-- 585
Query: 576 WKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREK 635
KE + P ++ +E + P E+ + D K +K R
Sbjct: 586 -KEPAPMKSKPPPTYESEEEDKCKP----------MSYEEKRQLSLDINKLPGEKLGRVV 634
Query: 636 EKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEK 695
+ + RE +K P + E+ P+T + + S L + E+ +
Sbjct: 635 HII--QSREPSLKNSNPDEI----EIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDV 688
Query: 696 VKEKEKKK---DKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVAL 752
+ K K + + + + ++ E E + ++K +E+ KH + +
Sbjct: 689 IAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQ 748
Query: 753 APSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAP 812
AP+PV P+ P P Q P PPP P P P
Sbjct: 749 APAPV-----------------------PQQPPPPPQQPPPPPPPQQQQQP------PPP 779
Query: 813 VPLPLLAQAAAGPALLPSPGP 833
P P + Q AA PA+ SP P
Sbjct: 780 PPPPSMPQQAA-PAMKSSPPP 799
Score = 40.0 bits (92), Expect = 0.010
Identities = 75/421 (17%), Positives = 152/421 (36%), Gaps = 33/421 (7%)
Query: 215 PLSSINTQKIPPMLSPVHVQDSTDLA---PPSPEPPMLAPVAKSQMPTAKP--LETKSFT 269
P + +Q PP+ P H L PP P P P + P +P L+ F+
Sbjct: 946 PSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFS 1005
Query: 270 PKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTH 329
+ GQ+ P Q P P + P+ V + SP KS P T H
Sbjct: 1006 THIQQPPPPQGQQPPHPPPGQQPP-PPQPAK-PQQVIQHHHSPRHHKS-----DPYSTGH 1058
Query: 330 IPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEA 389
+ + P +P + + ++ ++ + +Q + S QP+ VV E
Sbjct: 1059 LREAP--SPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVK---EE 1113
Query: 390 SIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGST 449
I + I R+ +PF S E P+ I P + + +
Sbjct: 1114 KIHSPIIRS------EPFSPSLRPEPP----KHPESIKAPVHLPQRPEMKPVDVGRPVIR 1163
Query: 450 PLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVY 509
P + + + V K NM + S P TP K
Sbjct: 1164 PPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG---SWASLVQKHPTTPSSTAKSS 1220
Query: 510 EEK-TKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKET 568
+ + + K++ +K LK + + EK+++R R+ + +++D +++ + E
Sbjct: 1221 SDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQ--ERMRSREDEDALEQARRAHEE 1278
Query: 569 GRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKK 628
R + ++ +E++ + P+ + ++++ +K+++E+ ++
Sbjct: 1279 ARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRR 1338
Query: 629 D 629
+
Sbjct: 1339 E 1339
Score = 37.7 bits (86), Expect = 0.050
Identities = 33/125 (26%), Positives = 60/125 (48%), Gaps = 21/125 (16%)
Query: 626 GKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALP-LFSPATASRVPAMLPSLLPV 684
G DKDK+++E P P V P K+L + + S A+ + PS
Sbjct: 1173 GAPDKDKQKQE-------------PKTP-VAPKKDLKIKNMGSWASLVQKHPTTPSSTAK 1218
Query: 685 LPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREK---EKEKHK 741
FE+ + ++K+++EK K + E +KEKER +++R R + ++ E+ +
Sbjct: 1219 SSSDSFEQ---FRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRA 1275
Query: 742 HEKIK 746
HE+ +
Sbjct: 1276 HEEAR 1280
Score = 35.4 bits (80), Expect = 0.25
Identities = 28/102 (27%), Positives = 36/102 (35%), Gaps = 11/102 (10%)
Query: 764 RVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPA------PAPAPGPMLVSPAPV---- 813
R G K +S V +A P P+ PP P PA P L+ PV
Sbjct: 183 RKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVV 242
Query: 814 -PLPLLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETVST 854
P PL P P P PA + P+ + + V T
Sbjct: 243 PPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKT 284
Score = 34.7 bits (78), Expect = 0.42
Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 14/142 (9%)
Query: 222 QKIPPMLSPVHVQDSTDLAPPSPEPPMLA---PVAKSQMPTAKPLETKSFT--------P 270
Q+ PP P + A S PP +A PV + Q+P + FT P
Sbjct: 774 QQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQP 833
Query: 271 KTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKS--PKSPKSPKVTT 328
+ P + + P Q A+V P + + R+ + PK + P V+
Sbjct: 834 ELPPHLPQPPEHSTPPHLNQH-AVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSP 892
Query: 329 HIPQTPVRPETPNRTPSATLSE 350
+ QTP+ P+ P P L E
Sbjct: 893 ALTQTPLLPQPPMAQPPQVLLE 914
Score = 34.3 bits (77), Expect = 0.55
Identities = 25/73 (34%), Positives = 35/73 (47%), Gaps = 13/73 (17%)
Query: 749 PVALAPSP---VIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAP-- 803
PV P P V P L ++ V++ V P P P P +P+ PPPAPAP P
Sbjct: 217 PVQATPHPFPAVTPDLIVQTP------VMTVVPPQPLQTPPPVPPQPQ-PPPAPAPQPVQ 269
Query: 804 -GPMLVSPAPVPL 815
P +++ P P+
Sbjct: 270 SHPPIIAATPQPV 282
Score = 34.3 bits (77), Expect = 0.55
Identities = 30/139 (21%), Positives = 61/139 (43%), Gaps = 15/139 (10%)
Query: 628 KDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPE 687
KDK K+E + ++ K+K L K P +TA E
Sbjct: 1177 KDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTP---SSTAKSSSDSFEQFRRAARE 1233
Query: 688 KLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKE----------REKEKREREKREKEK 737
K EE+EK + + + +KEK++ +++ +E E E +R+ +++++ +
Sbjct: 1234 K--EEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQ 1291
Query: 738 EKHKHEKIKVEPVALAPSP 756
E+ + ++ + VA A +P
Sbjct: 1292 EQQQQQQQQAAAVAAAATP 1310
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 80.9 bits (198), Expect = 5e-15
Identities = 124/574 (21%), Positives = 237/574 (41%), Gaps = 79/574 (13%)
Query: 234 QDSTDLAPPSPEPPMLAPV-AKSQMPTAK--PLETKSFTPKTKTKTSSPGQKTKSPKTAQ 290
Q T L P P L+P A + PT++ P + TPK K+K T S A
Sbjct: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPK-KSKARILESITVSSLMAT 239
Query: 291 SPAMVGSPIRSPKTVSK---EKKSPGRSKSPKSPKSP---------------------KV 326
G + + ++ SK + SPG SP P SP
Sbjct: 240 PQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTD 299
Query: 327 TTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKT 386
+ + +P+ P +P+ A ++K+ V++ A K E ++
Sbjct: 300 SQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRL-AKKTAEEPAASGRIICHSY 358
Query: 387 IEASIDAVIARAC-AEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTK 445
+E ++ + + +E++ P E + +E ++ + S P T A+++ N
Sbjct: 359 LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
Query: 446 SGSTPLPLSGGTS--------------SSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPY 491
+ S P +G S+ + ++ E+ + L PP
Sbjct: 419 ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
Query: 492 ISSPSVSPPTPEPL----HKVYEEK-----TKLPSSVEVKKKLKKELKTKMKKKEKQRDR 542
SSP + PL H V + T P SV +K +K+ +M KEK+R R
Sbjct: 479 PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV-MKSFIKRNTPLRMDPKEKERQR 537
Query: 543 EREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK---------EEEADPYKFKIK 593
E + K+++++ + K +E + E K +E L+ E+ + K +I+
Sbjct: 538 -LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE 596
Query: 594 E-FEDVDPKV-KLKDGLVRKEKEKHKDK-KKDREKGKKDKDKREKEKVKDKGREDKMKAP 650
+ F +D K K K+ + +EK K K KK E + K + E +++ +E++ +
Sbjct: 597 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 656
Query: 651 APPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKK 710
L +E L A A R L E+ +E+ + + +E+++ ++E+++
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKR-----------LAEQREQERREQERREQERREQERRE 705
Query: 711 KKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
++ +E+E++ E+E+ +RE+E+ + E+E + EK
Sbjct: 706 QERREQERQLAEQER-RREQERLQAERELQEREK 738
Score = 72.0 bits (175), Expect = 2e-12
Identities = 112/541 (20%), Positives = 221/541 (40%), Gaps = 113/541 (20%)
Query: 239 LAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSP 298
+AP SP P +LA + S K ++ ++ + KTA+ PA G
Sbjct: 308 IAPSSPSPQVLA-------------QKYSLVAKQESVVRRASRRL-AKKTAEEPAASGRI 353
Query: 299 I-----------RSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQ-------TPVRPETP 340
I P+ V E+K P P + P+V + T + TP
Sbjct: 354 ICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTP 413
Query: 341 NRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACA 400
N P+A+ S ET Q + D + + +P ++ ++ + ++
Sbjct: 414 NPKPAAS-----SPETPSAGQQEAKTD--QADGPREPPQSARRKRSYKQAV--------- 457
Query: 401 EREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSS 460
SE + + + + P TP + A+ + PL T
Sbjct: 458 ------------SELDEEQHLEDEELQPPRSKTPSSPCPASKVVR----PLRTFLHTVQR 501
Query: 461 DNSWTMDASIDEVVRKA--KLGTPSNMPPNFPYISSPSVSPPTPEP----LHKVYEEKTK 514
+ S V K+ K TP M P E KV E+K +
Sbjct: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRR 561
Query: 515 LPSSVEVKK--KLKKELKTKMK----KKEKQRDRER---EKDKNKDKSKEKDKVKEKEKD 565
V++K+ +L+K L+ + + K+EK++ E+ + D+ +K+KE+ +EK K
Sbjct: 562 RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK 621
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK---- 621
K ++ + +EEEA ++ +E E+ + L++K+KE+ +++ +
Sbjct: 622 KAAAKKMEEVEARRKQEEEARRLRWLQQEEEE-----RRHQELLQKKKEEEQERLRKAAE 676
Query: 622 ------DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVP 675
RE+ ++++++RE+E+ + + RE + + L + R+
Sbjct: 677 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR--------REQERLQ 728
Query: 676 AMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREK 735
A E+ +E+EK +K++ ++E ++KK+KE++++ ER+ ++ E+EK+ K
Sbjct: 729 A----------ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE-EQEKKAK 777
Query: 736 E 736
E
Sbjct: 778 E 778
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/132 (22%), Positives = 73/132 (55%), Gaps = 1/132 (0%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEF 579
E +++ +EL K K++E++R R+ + K + +E+++ +E+E+ ++ RE + +E
Sbjct: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER-REQERREQERREQERREQER 708
Query: 580 LKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVK 639
++E + + +E E + + +L++ +K + +++ EK KK++ +R E+
Sbjct: 709 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 768
Query: 640 DKGREDKMKAPA 651
+ +E K K A
Sbjct: 769 QEEQEKKAKEAA 780
Score = 32.7 bits (73), Expect = 1.6
Identities = 52/264 (19%), Positives = 102/264 (38%), Gaps = 42/264 (15%)
Query: 518 SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK 577
+VEV +K+ E K ++ E E E +N + D E T P K
Sbjct: 364 NVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWP------HNDTEIANSTPNP-K 416
Query: 578 EFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEK 637
E + + + D + RK K + D E+ +D++ +
Sbjct: 417 PAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPP-- 474
Query: 638 VKDKGREDKMKAPAPPLVLPPKELALP------LFSPATASR--VPAMLPSLLPVLPEKL 689
+ + PA +V P + L +P +A R + + + P+ +
Sbjct: 475 ---RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPK 531
Query: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKRE---------REKREKEKEKH 740
+E+++++ +K++ ++ +++K +E +++ E K KRE RE+ E+ KE+
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591
Query: 741 KH-------------EKIKVEPVA 751
K EK K E +A
Sbjct: 592 KKQIEQKFAQIDEKTEKAKEERLA 615
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 79.7 bits (195), Expect = 1e-14
Identities = 61/256 (23%), Positives = 127/256 (49%), Gaps = 68/256 (26%)
Query: 506 HKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKD-KNKDKSKEKDKVKEKEK 564
HK EE E KK K+ + + +++E++R+RERE++ + +++ +E+++ +EKEK
Sbjct: 288 HKKLEE--------EKGKKEKERQEIEKERRERERERERERERREREREREREREREKEK 339
Query: 565 DKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDRE 624
++E RE ++ KE + D + + ++ + + KD +EK + ++++++RE
Sbjct: 340 ERERERERDRD-RDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERE 398
Query: 625 KGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPV 684
+ ++ + +RE+E+ +++ RE
Sbjct: 399 RERERERERERERERERERE---------------------------------------- 418
Query: 685 LPEKLFEEKEKVKEKEKKKDKKE-----------KKKKKEKEKEKKEKEREKEKREREK- 732
E+E+ +EK+KK+D++E ++K +EKE +E+ + E RER+K
Sbjct: 419 ------REREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKT 472
Query: 733 REKEKEKHKHEKIKVE 748
RE EKE + E+ + E
Sbjct: 473 REYEKEAEREEERRRE 488
Score = 79.3 bits (194), Expect = 1e-14
Identities = 54/231 (23%), Positives = 124/231 (53%), Gaps = 23/231 (9%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK 566
K+ EEK K + +K ++E + + +++ ++R+RERE+++ +++ KEK++ +E+E+D+
Sbjct: 290 KLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDR 349
Query: 567 ETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKG 626
+ R + ++ + D + + ++ E + K + K +++ ++++++RE+
Sbjct: 350 DRDRTKE-------RDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERE 402
Query: 627 KKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLP 686
++ + +RE+E+ +++ RE + + K A R L
Sbjct: 403 REREREREREREREREREREREREK-----DKKRDREEDEEDAYERR----------KLE 447
Query: 687 EKLFEEKEKVKEKEKKKDKKEKKKKKEKEKE-KKEKEREKEKREREKREKE 736
KL E++ +E+ K + +E+KK +E EKE ++E+ER +E + KR KE
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKE 498
Score = 71.6 bits (174), Expect = 3e-12
Identities = 66/313 (21%), Positives = 144/313 (46%), Gaps = 57/313 (18%)
Query: 512 KTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRE 571
K + S + + + ++ + + +++E++R+RERE+++ +++ +E+++ K+K++D+E E
Sbjct: 379 KDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE 438
Query: 572 TKYPWKEF---LKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKK 628
Y ++ L+E+EA Y+ ++K +E + K K KE E+ ++++++ K K
Sbjct: 439 DAYERRKLERKLREKEA-AYQERLKNWEIRERK---KTREYEKEAEREEERRREMAKEAK 494
Query: 629 -----------DKDK---------------REKEKVKDKGREDKMKAPAPPLVLPPKELA 662
D+D REKE D+ + K +E+
Sbjct: 495 RLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL-------EEIR 547
Query: 663 LPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKE 722
L + P+ + E+ E+ ++ K++ + +E+E+EK+EKE
Sbjct: 548 QRLLAEGHPD-------------PDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKE 594
Query: 723 REKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDKIVISKVVPAPE 782
++E E + E+E E+ K + P++ APS D+ ++P
Sbjct: 595 EKRE--EPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHEN 652
Query: 783 A--KPAPSQNRPK 793
+ + P ++RPK
Sbjct: 653 SPDQQQPEEHRPK 665
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/269 (21%), Positives = 128/269 (47%), Gaps = 59/269 (21%)
Query: 487 PNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREK 546
P P I P + T E ++ + E+ K + +++ K T K +E++ +E+E+
Sbjct: 249 PVAPLIPYPLI---TKEDINAIEMEEDKRDL---ISREISKFRDTHKKLEEEKGKKEKER 302
Query: 547 DKNKDKSKEKDKVKEKEKD-KETGRE-----TKYPWKEFLKEEEADPYKFKIKEFEDVDP 600
+ + + +E+++ +E+E++ +E RE + KE +E E D + + KE +
Sbjct: 303 QEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRD 362
Query: 601 KVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKE 660
+ + +D + +++KD+ + REK + + +RE+E+ +++ RE +
Sbjct: 363 RERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERE-------------- 408
Query: 661 LALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKE 720
E+E+ +E+E++++++ +K KK +E +E
Sbjct: 409 ------------------------------REREREREREREREREREKDKKRDREEDEE 438
Query: 721 KEREKEKREREKREKE---KEKHKHEKIK 746
E+ K ER+ REKE +E+ K+ +I+
Sbjct: 439 DAYERRKLERKLREKEAAYQERLKNWEIR 467
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/227 (18%), Positives = 106/227 (46%), Gaps = 36/227 (15%)
Query: 542 REREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFL---------------KEEEAD 586
RE + N + ++K+K+K+ ++P + +E++ D
Sbjct: 216 REYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRD 275
Query: 587 PYKFKIKEFEDVDPKVKLKDGLVRKE--------KEKHKDKKKDREKGKKDKDK-REKEK 637
+I +F D K++ + G KE +E+ ++++++RE+ ++++++ RE+E+
Sbjct: 276 LISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERER 335
Query: 638 VKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK 697
K+K RE + + ++ R K++ +
Sbjct: 336 EKEKERERERERDRDRDRTKERDRDRDRERDRDRDR------------ERSSDRNKDRSR 383
Query: 698 EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
+EK +D++ +++++ + + ++E+ERE+E+ +RE+E+E+ K +K
Sbjct: 384 SREKSRDREREREREREREREREREREREREREREREREREREKDKK 430
Score = 58.5 bits (140), Expect = 3e-08
Identities = 46/156 (29%), Positives = 86/156 (55%), Gaps = 10/156 (6%)
Query: 596 EDVDPKVKLKDGLVRKEKEKH-KDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPL 654
E +D + K +D +++ E ++ + ++ D ++K K+K + + P PL
Sbjct: 194 EALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPL 253
Query: 655 VLPP---KELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKK---KDKKEK 708
+ P KE + + + S +KL EEK K KEKE++ K+++E+
Sbjct: 254 IPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK-KEKERQEIEKERRER 312
Query: 709 KKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
++++E+E+E++E+ERE+E RERE REKEKE+ + +
Sbjct: 313 ERERERERERRERERERE-RERE-REKEKERERERE 346
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 78.2 bits (191), Expect = 3e-14
Identities = 113/572 (19%), Positives = 237/572 (41%), Gaps = 86/572 (15%)
Query: 234 QDSTDLAPPSPEPPMLAPV-AKSQMPTAK--PLETKSFTPKTKTKTSSPGQKTKSPKTAQ 290
Q T L P P L+P A + PT++ P + TPK K+K T S A
Sbjct: 181 QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPK-KSKARILESITVSSLMAT 239
Query: 291 SPAMVGSPIRSPKTVSK---EKKSPGRSKSPKSPKSP---------------------KV 326
G + + ++ SK + SPG SP P SP
Sbjct: 240 PQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTD 299
Query: 327 TTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKT 386
+ + +P+ P +P+ A ++K+ V++ A K E ++
Sbjct: 300 SQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRL-AKKTAEEPAASGRIICHSY 358
Query: 387 IEASIDAVIARAC-AEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTK 445
+E ++ + + +E++ P E + +E ++ + S P T A+++ N
Sbjct: 359 LERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
Query: 446 SGSTPLPLSGGTS--------------SSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPY 491
+ S P +G S+ + ++ E+ + L PP
Sbjct: 419 ASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKT 478
Query: 492 ISSPSVSPPTPEPL----HKVYEEK-----TKLPSSVEVKKKLKKELKTKMKKKEKQRDR 542
SSP + PL H V + T P SV +K +K+ +M K ++
Sbjct: 479 PSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV-MKSFIKRNTPLRMDPKCSFVEK 537
Query: 543 EREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEF-----ED 597
ER++ +N + +E ++++ ++ +++ R + + LK EE + +E E+
Sbjct: 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLE---EVKLKREERLRKVLQARERVEQMKEE 594
Query: 598 VDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLP 657
+++ K + ++ EK K+++ EK KK ++ E+V+ + ++++
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE----------- 643
Query: 658 PKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKE 717
A R+ + ++L ++K++ +++ +K + K+ +++E+E
Sbjct: 644 ------------EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 691
Query: 718 KKEKER-EKEKREREKREKEKEKHKHEKIKVE 748
++E+ER E+E+RE+E+RE+E+ + + + + E
Sbjct: 692 RREQERREQERREQERREQERREQERQLAEQE 723
Score = 76.3 bits (186), Expect = 1e-13
Identities = 110/545 (20%), Positives = 216/545 (39%), Gaps = 117/545 (21%)
Query: 239 LAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSP 298
+AP SP P +LA + S K ++ ++ + KTA+ PA G
Sbjct: 308 IAPSSPSPQVLA-------------QKYSLVAKQESVVRRASRRL-AKKTAEEPAASGRI 353
Query: 299 I-----------RSPKTVSKEKKSPGRSKSPKSPKSPKVTTHIPQ-------TPVRPETP 340
I P+ V E+K P P + P+V + T + TP
Sbjct: 354 ICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTP 413
Query: 341 NRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACA 400
N P+A+ S ET Q + D + + +P ++ ++ + ++
Sbjct: 414 NPKPAAS-----SPETPSAGQQEAKTD--QADGPREPPQSARRKRSYKQAV--------- 457
Query: 401 EREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTSANNFTKSGSTPLPLSGGTSSS 460
SE + + + + P TP + A+ + PL T
Sbjct: 458 ------------SELDEEQHLEDEELQPPRSKTPSSPCPASKVVR----PLRTFLHTVQR 501
Query: 461 DNSWTMDASIDEVVRKA--KLGTPSNMPPNFPYISSPSVS------PPTPEPLHKVYEEK 512
+ S V K+ K TP M P ++ E L + E+
Sbjct: 502 NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEE 561
Query: 513 TKLPSSVEVKKKLKKELKTKMKKKEKQRDREREK-----------DKNKDKSKEKDKVKE 561
K EVK K ++ L+ ++ +E+ + EK D+ +K+KE+ +E
Sbjct: 562 DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE 621
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
K K K ++ + +EEEA ++ +E E+ + L++K+KE+ +++ +
Sbjct: 622 KAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE-----RRHQELLQKKKEEEQERLR 676
Query: 622 ----------DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATA 671
RE+ ++++++RE+E+ + + RE + + L +
Sbjct: 677 KAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR--------REQ 728
Query: 672 SRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKRERE 731
R+ A E+ +E+EK +K++ ++E ++KK+KE++++ ER+ ++ E+E
Sbjct: 729 ERLQA----------ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE-EQE 777
Query: 732 KREKE 736
K+ KE
Sbjct: 778 KKAKE 782
Score = 41.6 bits (96), Expect = 0.003
Identities = 30/132 (22%), Positives = 73/132 (55%), Gaps = 1/132 (0%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEF 579
E +++ +EL K K++E++R R+ + K + +E+++ +E+E+ ++ RE + +E
Sbjct: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER-REQERREQERREQERREQER 712
Query: 580 LKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVK 639
++E + + +E E + + +L++ +K + +++ EK KK++ +R E+
Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
Query: 640 DKGREDKMKAPA 651
+ +E K K A
Sbjct: 773 QEEQEKKAKEAA 784
Score = 32.3 bits (72), Expect = 2.1
Identities = 21/71 (29%), Positives = 42/71 (59%), Gaps = 10/71 (14%)
Query: 691 EEKEKVKEKEKKKDKK----EKKKKKEKEKEKKEKEREKEKREREKREKEKEK------H 740
EE E+++ ++ ++DK+ E K K+E+ K + RE+ ++ +E+++K+ E+
Sbjct: 549 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 608
Query: 741 KHEKIKVEPVA 751
K EK K E +A
Sbjct: 609 KTEKAKEERLA 619
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 77.8 bits (190), Expect = 4e-14
Identities = 63/256 (24%), Positives = 141/256 (55%), Gaps = 44/256 (17%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKE------ 563
E+ +L + K++ +EL+ KM ++EK R++E EK + ++K +E++K +E+E
Sbjct: 363 EKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE-EKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 564 --KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL--KDGLVRKEKE--KHK 617
K +E + + K+ ++EE + KI+E E + ++ ++ +R+++E + K
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 481
Query: 618 DKKKDREKGKKDKDK--REKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVP 675
+K ++EK +K ++K R++EK+ D+ E+K++ + +++
Sbjct: 482 EKMHEQEKIRKQEEKVWRQEEKMHDQ--EEKIREQEEKMWRQEEKIREQ----------- 528
Query: 676 AMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKK------KKKEKEKEKKEKEREKEKRE 729
EK+ E++EK++E+E+ ++E+K K +E+EK ++++E+ +E+ E
Sbjct: 529 ----------EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE 578
Query: 730 REKREKEKEKHKHEKI 745
+ + +KEK + + EKI
Sbjct: 579 KIREQKEKIREQEEKI 594
Score = 77.8 bits (190), Expect = 4e-14
Identities = 55/239 (23%), Positives = 136/239 (56%), Gaps = 9/239 (3%)
Query: 508 VYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKE 567
++E++ K+ E + +K + + K++E+++ RE+EK + ++ + + K +E++++
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 568 TGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKE--KHKDKKKDREK 625
+ K W++ K E + K + +E ++ ++ +R+++E + K+K ++EK
Sbjct: 432 IREQEKKMWRQEEKIHEQE--KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 626 GKKDKDK--REKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
+K ++K R++EK+ D +E+K++ + +++ ++
Sbjct: 490 IRKQEEKVWRQEEKMHD--QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ 547
Query: 684 VLPEKLFEEKEKVKEKEKKKDKKEK-KKKKEKEKEKKEKEREKEKREREKREKEKEKHK 741
EK+ E++EK++E+EK + ++EK ++++EK +E+KEK RE+E++ E+ EK +E+ +
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEE 606
Score = 74.7 bits (182), Expect = 4e-13
Identities = 55/250 (22%), Positives = 142/250 (56%), Gaps = 13/250 (5%)
Query: 507 KVYEEKTKLPSSVEVKKKLKK-ELKTKM-KKKEKQRDRE---REKDKNKDKSKEKDKVKE 561
K+ E++ K +++++ K+ E + KM +++EK R++E RE++K + +EK +E
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 450
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
K +++E +E + W++ K E + + ++ + + K ++ + R+E++ H ++K
Sbjct: 451 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510
Query: 622 DREKGKK-----DKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPA 676
RE+ +K +K + ++EK++++ E+K++ + +++ ++
Sbjct: 511 IREQEEKMWRQEEKIREQEEKIREQ--EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 677 MLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKE 736
+ EK+ E+KEK++E+E+K ++E+K ++++E ++++E+ E+ E+ ++E
Sbjct: 569 QEEKIREQ-EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 737 KEKHKHEKIK 746
K + + EK++
Sbjct: 628 KMQEQEEKMR 637
Score = 74.7 bits (182), Expect = 4e-13
Identities = 51/241 (21%), Positives = 137/241 (56%), Gaps = 20/241 (8%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK 566
K++ ++ K+ +++++ K++ + +M ++E++ + E + K+K E++K++++E+
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
Query: 567 ETGRETKYPWKEFLKEEEADPYK--FKIKEFEDVDPKVKLKDGLVRKEKE---KHKDKKK 621
E + +E ++E+E ++ KI+E E+ K++ ++ +R+++E + ++K
Sbjct: 498 WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEE---KIREQEEKIREQEEMMQEQEEKMG 554
Query: 622 DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSL 681
++E+ ++++K +++ K + +E+K++ + +E ++ R +
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI----REQEEKIWEQEEKIREQ---EEM 607
Query: 682 LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK 741
+ EK++E++EK+ E+E+K ++E EK + ++EK E+E R R++ EK +E +
Sbjct: 608 MQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Query: 742 H 742
H
Sbjct: 663 H 663
Score = 70.5 bits (171), Expect = 7e-12
Identities = 59/264 (22%), Positives = 143/264 (54%), Gaps = 20/264 (7%)
Query: 503 EPLHKVYEEKTKLPSSVEV----KKKLKKELKTKMKKKEKQRDRER---EKDKNKDKSKE 555
E K+ E++ K+ E+ ++K++++ + +K+EK R E EK++ + +E
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEE 384
Query: 556 KDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKE-FEDVDPKVKLKDGLVRKEKE 614
K +EK +++E R+ + +E K +E + ++ +E + + K++ ++ + +++E
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444
Query: 615 KHKDKKKDREKGKKDKDK---REKEKVKDK----GREDKMKAPAPPLVLPPKELALPLFS 667
K +++K RE+ K+ + + R++EK++++ +++KM K
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKM 504
Query: 668 PATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEK----EKKEKER 723
++ + EK+ E++EK++E+E+K ++E+ ++++EK E+K +E+
Sbjct: 505 HDQEEKIREQEEKMWR-QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 724 EKEKREREKREKEKEKHKHEKIKV 747
EK +R+ EK +++EK + +K K+
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKI 587
Score = 69.7 bits (169), Expect = 1e-11
Identities = 57/249 (22%), Positives = 134/249 (53%), Gaps = 48/249 (19%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRER-EKDKNKDKSKEKDKVKE 561
E L V EK+++ +V+ K+ + K + +++ Q + + K+ +K + +V+E
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
E ++ + K + +EE+ ++ KI+E E+ K++ ++ +R+++EK + +++
Sbjct: 288 NELWNRLNQQQEE--KMWRQEEKIQEWEEKIQEQEE---KIREQEEKIREQEEKMR-RQE 341
Query: 622 DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSL 681
+ K++K +R++E + +K E+KM+
Sbjct: 342 EMMWEKEEKMRRQEEMMWEK--EEKMRR-------------------------------- 367
Query: 682 LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREK----REKEK 737
L E ++E++EK++E E+K ++EK +++E++++++EK RE+EKR+ ++ R++EK
Sbjct: 368 ---LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 424
Query: 738 EKHKHEKIK 746
+ + EKI+
Sbjct: 425 IREQEEKIR 433
Score = 68.2 bits (165), Expect = 3e-11
Identities = 50/238 (21%), Positives = 125/238 (52%), Gaps = 46/238 (19%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK-- 577
E+ +L ++ + KM ++E++ EK + +++ + + K +E++++ R+ + W+
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 348
Query: 578 -------EFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK 630
E + E+E + + +E + +L++ + +EK + +++K+ E+ +++
Sbjct: 349 EKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 408
Query: 631 DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLF 690
+KR++++ K +E+K++ EK+
Sbjct: 409 EKRQEQEAKMWRQEEKIREQE-----------------------------------EKIR 433
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEK-REREKREKEKEK-HKHEKIK 746
E+++K+ +E+K ++EK +++EK +E++E R++EK RE+E+ ++KEK H+ EKI+
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/237 (21%), Positives = 125/237 (52%), Gaps = 45/237 (18%)
Query: 507 KVYEEKTKLPS---SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKE 563
K++ ++ K+ ++ +++ +E + K++++E++ R+ E K++ + + E
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 564 KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDR 623
K+++ R + W+ KEE KI+E L++ + +EK + +++K+
Sbjct: 361 KEEKMRRLEEMMWE---KEE-------KIRE---------LEEKMHEQEKIREQEEKRQE 401
Query: 624 EKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLP 683
E+ ++++KR++++ K +E+K++ + K++
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM---------------------- 439
Query: 684 VLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEK-REREKREKEKEK 739
E+ E+EK++E+EK+++++E +++EK +E++E R+KEK E+EK K++EK
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496
Score = 42.7 bits (99), Expect = 0.002
Identities = 28/136 (20%), Positives = 78/136 (57%), Gaps = 4/136 (2%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKEL---KTKMKKKEKQRDREREKDKNKDKSKE-KDK 558
E K+ E++ K+ E+ ++ ++++ + KM+++EK R +E + + ++K +E K+K
Sbjct: 527 EQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 559 VKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKD 618
++E+E+ E +E ++E+E ++ + K E + + ++ + R+E++ +
Sbjct: 587 IREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 646
Query: 619 KKKDREKGKKDKDKRE 634
+ + R++ +K ++ +E
Sbjct: 647 EVRLRQQEEKMQEHQE 662
Score = 39.7 bits (91), Expect = 0.013
Identities = 41/177 (23%), Positives = 89/177 (50%), Gaps = 22/177 (12%)
Query: 581 KEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKD 640
++++AD Y ++ + D ++L + E+ K K+ K K + EK +++
Sbjct: 187 QKKKADRYIEELTKERDA-LSLELYRNTITDEELKEKNAKLQE---KLQLVESEKSEIQL 242
Query: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFE--------- 691
+E K K L+LP ++L A A + L S+ L ++ E
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQ------AEADHLGKELQSVSAKLQAQVEENELWNRLNQ 296
Query: 692 --EKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
E++ +++EK ++ +EK +++E EK ++++E+ +E+ E+ +R++E K EK++
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQE-EKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 77.8 bits (190), Expect = 4e-14
Identities = 62/256 (24%), Positives = 138/256 (53%), Gaps = 42/256 (16%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKV--- 559
E K++E++ K+ E+ + KK M ++EK R++E + + ++K +++++
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKK-----MWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562
Query: 560 KEKEKDKETGRETKYPW--KEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHK 617
+E+ +K+T + K W +E ++EEE + + K++ ++ ++R+++EK +
Sbjct: 563 QEERMEKKTQEQEKKTWDQEEKMREEE---------RMREREKKMREEEEMMREQEEKMQ 613
Query: 618 DKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAM 677
+++ EK ++ ++K +++ K + +E+KM + +++
Sbjct: 614 EQE---EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM---------------W 655
Query: 678 LPSLLPVLPEKLFE-----EKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREK 732
LP EKL+E E+EK++E+E+K ++EK +KK +E+EKK ++EK + E
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 733 REKEKEKHKHEKIKVE 748
RE+EK+ + E++ E
Sbjct: 716 REREKKMREEEEMMRE 731
Score = 72.8 bits (177), Expect = 1e-12
Identities = 59/257 (22%), Positives = 144/257 (56%), Gaps = 20/257 (7%)
Query: 501 TPEPLHKVYEEKTKLPSSVEVK---KKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKD 557
T E K ++++ K+ ++ KK+++E + +++EK +++E + + ++K E++
Sbjct: 571 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQE 630
Query: 558 KVKEKEKDKETGRETK-YPWKEFLKEEEADP-YKFKIKEFEDVDPKVKLKDGLVRKEK-- 613
+ +++++K +E K + +E + E++ P K K+ E E + + K+++ ++EK
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE---QEEKIW 687
Query: 614 EKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASR 673
E+ K +KK +E+ KK D+ EK + ++ RE + K ++ +E + +
Sbjct: 688 EQEKMEKKTQEQEKKTWDQ-EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746
Query: 674 VPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEK----KKKKEKEKEKKEKEREKEKRE 729
M EK++E++EK+ E+++ ++KEK +K +E+EK +++E+ +++ E
Sbjct: 747 EEEMWEQ-----EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801
Query: 730 REKREKEKEKHKHEKIK 746
+ + ++EK + + EK++
Sbjct: 802 KMRGQEEKMRGQEEKMR 818
Score = 70.1 bits (170), Expect = 9e-12
Identities = 56/253 (22%), Positives = 138/253 (54%), Gaps = 33/253 (13%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRD-REREKDKNKDKSK---EKDKVKEK 562
K+ E++ K+ + ++ +KEL+ + K+ +Q++ RE+E+ + + K +++K++E+
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
Query: 563 EKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEK------EKH 616
E+ E + ++ ++E+E + + +E D +++ K+ +R+++ EK
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ-DERLREKEERMREQEKMWEQVEKM 426
Query: 617 KDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPA 676
+++KK +E+ KK +D+ EK + +++ RE + K + +E
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE---------------- 470
Query: 677 MLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKRE-- 734
+ E ++E++EK ++++ ++KEK ++EK +E++EK E+E++ R++ E
Sbjct: 471 ---EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 735 -KEKEKHKHEKIK 746
+EK+ + EK++
Sbjct: 528 GQEKKMWRQEKMR 540
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/270 (22%), Positives = 140/270 (51%), Gaps = 31/270 (11%)
Query: 510 EEKTKLPSSV-EVKKKLKKELKT------KMKKKEKQRDREREKD-------KNKDKSKE 555
EEK + + E +KK+++E +T KM+K+E+ + EK+ + K+K E
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 556 KDKVKEKEK----DKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRK 611
++K++E+E+ +E R+ + W + K + + + + + + K++ ++ +
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562
Query: 612 EKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATA 671
++E+ + K +++EK D++++ +E+ + + RE KM+ + +++
Sbjct: 563 QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 622
Query: 672 SRVPAMLPSLLPVLPEKLFEEKEKVKEKEKK----------KDK---KEKKKKKEKEKEK 718
+ EK++E++EK+ E+E+K K+K EK +++EK +E+
Sbjct: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 719 KEKEREKEKREREKREKEKEKHKHEKIKVE 748
+EK E+EK E++ +E+EK+ EK++ E
Sbjct: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712
Score = 67.4 bits (163), Expect = 6e-11
Identities = 57/244 (23%), Positives = 129/244 (52%), Gaps = 57/244 (23%)
Query: 511 EKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGR 570
E+ K+ VE K+++E K + ++K K RD+E +K +E+++++E+EK
Sbjct: 415 EQEKMWEQVE---KMREEKKMQEQEK-KTRDQE-------EKMQEEERIREREKKMREEE 463
Query: 571 ETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK 630
ET +E ++++E + ++ + KE++ R ++K K ++++ + +++K
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQ-----------QRLPEQKEKLWEQEKMQEQEEK 512
Query: 631 DKREKEKVKDK----GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLP 686
++EK++D+ G+E KM +
Sbjct: 513 IWEQEEKIRDQEEMWGQEKKM-----------------------------WRQEKMREQE 543
Query: 687 EKLFEEKEKVKEKEKKK-DKKEKKKKKEKEKEKKEKEREKEKREREK-REKEKEKHKHEK 744
++++E++EK++++E+K D++E+ +KK +E+EKK ++E++ RE E+ RE+EK+ + E+
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 745 IKVE 748
+ E
Sbjct: 604 MMRE 607
Score = 66.6 bits (161), Expect = 1e-10
Identities = 57/252 (22%), Positives = 131/252 (51%), Gaps = 30/252 (11%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK 566
K+ E++ K+ +++KK +++ K K +EK R+ E +++ K +E++ ++E+E+
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEK-KTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Query: 567 ETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKG 626
+ E +E + E+E ++ + K +E + +L + +KEK +K +++EK
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWE----QQRLPE---QKEKLWEHEKMQEQEKI 789
Query: 627 KKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLP 686
+ ++K ++ K +G+E+KM+ + +++
Sbjct: 790 WEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ---------------------E 828
Query: 687 EKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
EK++ ++EK+ +E+K +E+K + EK + ++EK RE+E++ R + EK +E+ + + +
Sbjct: 829 EKMWGQEEKMWGQEEKMWGQEEKME-EKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Query: 747 VEPVALAPSPVI 758
E + SP I
Sbjct: 888 EEKIYCVGSPPI 899
Score = 64.3 bits (155), Expect = 5e-10
Identities = 49/227 (21%), Positives = 122/227 (53%), Gaps = 34/227 (14%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKS-KEKDKVKEKEKDKETGRETKYPWKE 578
E +KK++K+ + +++E+ R++E + + ++K +++ +++E+EK+ + KE
Sbjct: 283 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKE 342
Query: 579 FLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV 638
L+E+E + + K +E + + ++ + R+E+ + +K+ RE+ +K +D+ E+
Sbjct: 343 -LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Query: 639 KD---KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEK 695
+D + +E++M+ M + + EK +E+EK
Sbjct: 402 QDERLREKEERMREQEK------------------------MWEQVEKMREEKKMQEQEK 437
Query: 696 VKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKH 742
K +D++EK +++E+ +E+++K RE+E+ RE+ EK +++ ++
Sbjct: 438 -----KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/252 (23%), Positives = 127/252 (50%), Gaps = 45/252 (17%)
Query: 501 TPEPLHKVYEE-KTKLPSSVEVKKKLK---KELKTKMKKKEKQRDREREKDKNKDKSKEK 556
T E L K E + KLP + K +++ KELK K+++ + + + ++ +++
Sbjct: 219 TNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE 278
Query: 557 DKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKH 616
++++E+EK E + +E L+E+E K++E E+ + R+EK
Sbjct: 279 EELREQEKKIRKQEEKMWRQEERLREQEG-----KMREQEEK---------MWRQEKRLR 324
Query: 617 KDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPA 676
+ +K+ RE+ K+ ++++E + +++ +E + K + +E
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE---------------- 368
Query: 677 MLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKE 736
EK++ ++E++ E+EK+ ++E+K + ++E+ ++ ER +EK ER RE+E
Sbjct: 369 ----------EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER-MREQE 417
Query: 737 KEKHKHEKIKVE 748
K + EK++ E
Sbjct: 418 KMWEQVEKMREE 429
Score = 44.3 bits (103), Expect = 5e-04
Identities = 43/167 (25%), Positives = 82/167 (49%), Gaps = 41/167 (24%)
Query: 617 KDKKKDR--EKGKKDKDKRE---------KEKVKDKGREDKMKAPAPP-----LVLPPKE 660
+ KK DR E+ K++D E++K K E + K P + L KE
Sbjct: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 661 LALPLFSPATASRVPAMLPSLLP-VLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEK--- 716
L L R +LP + L E+++ ++E+++E+EKK K+E+K +++E+
Sbjct: 251 LKRKL------ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE 304
Query: 717 ---------------EKKEKEREKEKREREKREKEKEKHKHEKIKVE 748
EK+ +E+EKE RE+EK +E+++ + ++ +++
Sbjct: 305 QEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQ 351
Score = 35.4 bits (80), Expect = 0.25
Identities = 27/122 (22%), Positives = 69/122 (56%), Gaps = 5/122 (4%)
Query: 502 PEPLHKVYE-EKTKLPSSVEVKKKLKKELKTKMK-KKEKQRDREREKDKNKDKSKEKDKV 559
PE K++E EK + + +++ ++ + KM+ ++EK R +E + ++K +++
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
Query: 560 KEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDK 619
+++K G+E K +E EE+ + K++E E+ K++ ++ +R+++EK + +
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE---KMRGQEEKMREQEEKMRGQ 887
Query: 620 KK 621
++
Sbjct: 888 EE 889
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 76.6 bits (187), Expect = 1e-13
Identities = 50/248 (20%), Positives = 144/248 (58%), Gaps = 18/248 (7%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKS-KEKDKVKEKE-- 563
+++ +K K+ E ++K++K+ + +++EK R++E + + ++K ++++K++E+E
Sbjct: 490 EIWRQKEKMH---EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM 546
Query: 564 -KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK-- 620
+++E E + W+E ++E+ D + ++ + + KV ++ +R+++EK ++++
Sbjct: 547 WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606
Query: 621 --KDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAML 678
K EK ++ ++K ++++ K + +E+K++ + +E + + M
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE--MTQEQEEKMGEQEEKMCEQEEKMQ 664
Query: 679 PSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKE 738
E ++ ++EK++E+EKK ++E+K ++++E ++++E+ E+ E+ ++EK
Sbjct: 665 EQ-----EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 719
Query: 739 KHKHEKIK 746
+ + EK++
Sbjct: 720 QEQEEKMR 727
Score = 75.1 bits (183), Expect = 3e-13
Identities = 56/245 (22%), Positives = 142/245 (57%), Gaps = 19/245 (7%)
Query: 507 KVYEEKTKLPSSVEVKKKLKK-ELKTKM-KKKEKQRDRE---REKDKNKDKSKEKDKVKE 561
K+ E++ K +++++ K+ E + KM +++EK R++E RE++K + +EK +E
Sbjct: 405 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
K +++E +E + W++ K E + + ++ + + K++ ++ V +++EK ++ ++
Sbjct: 465 KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIRE-QE 523
Query: 622 DREKGKKDKDKREKEKVKDK---GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAML 678
++ + +++K R++EK++++ RE++ + K ++
Sbjct: 524 EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQ- 582
Query: 679 PSLLPVLPEKLFEEKEKVKEKEKKKDKKEKK--KKKEKEKEKKEKEREKEKREREKREKE 736
EK++ ++EK++E+E+K+ ++E+K K++EK +E++EK +E+E++ RE+ EK
Sbjct: 583 -------EEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 737 KEKHK 741
+E+ +
Sbjct: 636 REQEE 640
Score = 70.5 bits (171), Expect = 7e-12
Identities = 54/253 (21%), Positives = 141/253 (55%), Gaps = 16/253 (6%)
Query: 508 VYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKE 567
++E++ K+ E + +K + + K++E+++ RE+EK + ++ + + K +E++++
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 568 TGRETKYPWK--EFLKEEEADPYKFKIKEFEDV---DPKVKLKDGLVRKEKEKHKDKKKD 622
+ K W+ E + E+E + K +E E++ + K+ ++ + R++++ H+ ++K
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 623 REKGKK-----DKDKREKEKVKDKGREDKMKAPAPPL----VLPPKELALPLFSPATASR 673
R++ +K +K + ++EK+++ +E+KM + + +E +
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIRE--QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 674 VPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKR 733
+ EK+ E++EKV +E+K ++E+K+++++EK K++E+ +E+ E+ +
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE 623
Query: 734 EKEKEKHKHEKIK 746
++EK + + EKI+
Sbjct: 624 QEEKIREQEEKIR 636
Score = 69.7 bits (169), Expect = 1e-11
Identities = 63/255 (24%), Positives = 141/255 (55%), Gaps = 62/255 (24%)
Query: 510 EEKTKLPSSV--EVKKKLKKELKTKMKKKEKQRDRER---EKDKN----KDKSKEKDKVK 560
EEK + + E ++K++++ + +K+EK R +E EK++ ++K E++K++
Sbjct: 348 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 407
Query: 561 EKEKDKETGRETKYPWKEFLKEEEADPYK--FKIKEFEDVDPKVKLKDGLVRKEKEKHKD 618
E+E+ ++ E K +E +E+EA ++ KI+E E+ K++ ++ + +++EK +
Sbjct: 408 EQEEKRQ--EEEKIREQEKRQEQEAKMWRQEEKIREQEE---KIREQEKKMWRQEEKIHE 462
Query: 619 KKKDREKGKKDKDK---REKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVP 675
++K RE+ K+ + + R++EK+ ++ + K
Sbjct: 463 QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK--------------------------- 495
Query: 676 AMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKE---REKEK-RERE 731
EK+ E++EK++++E+K ++E+K ++++EK ++++E R++EK RE+E
Sbjct: 496 -----------EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 732 KREKEKEK-HKHEKI 745
+ +E+EK H+ EKI
Sbjct: 545 EMWREEEKMHEQEKI 559
Score = 68.9 bits (167), Expect = 2e-11
Identities = 57/250 (22%), Positives = 141/250 (56%), Gaps = 24/250 (9%)
Query: 507 KVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDK 566
KV+ ++ K+ E ++K++++ + +++EK R++E E + ++K E++K+ E+EK +
Sbjct: 511 KVWRQEEKIR---EQEEKIREQEEKMWRQEEKIREQE-EMWREEEKMHEQEKIWEEEKRQ 566
Query: 567 ETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK----KD 622
E +E K W++ EE KI+E E+ KV ++ +R+++EK ++++ K
Sbjct: 567 E--QEDKM-WRQ---EE-------KIREQEE---KVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 623 REKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLL 682
EK ++ ++K ++++ K + +E+K++ +++ +
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 683 PVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKH 742
EK+ E+++K++E+E+K ++E+ ++++EK +++E+ E+ E+ + ++EK + +
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 743 EKIKVEPVAL 752
EK+ + V L
Sbjct: 731 EKMWEQEVRL 740
Score = 66.6 bits (161), Expect = 1e-10
Identities = 63/261 (24%), Positives = 143/261 (54%), Gaps = 34/261 (13%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRER-EKDKNKDKSKEKDKVKE 561
E L V EK+++ +V+ K+ + K + +++ Q + + K+ +K + +V+E
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
E ++ + K + +EE+ ++ KI+E E+ K++ ++ +R+++EK + +++
Sbjct: 288 NELWNRLNQQQEE--KMWRQEEKIQEWEEKIQEQEE---KIREQEEKIREQEEKMR-RQE 341
Query: 622 DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAML--- 678
+ K++K +R++E + +K E+KM+ + +++ R M+
Sbjct: 342 EMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKMR----------RQEEMMWEK 389
Query: 679 PSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKE-------KKEKEREKEKRERE 731
+ L EK+ E+ EK++E+E+K+ ++EK +++EK +E ++EK RE+E++ RE
Sbjct: 390 EEKIRELEEKMHEQ-EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 448
Query: 732 KREK----EKEKHKHEKIKVE 748
+ +K E++ H+ EKI+ E
Sbjct: 449 QEKKMWRQEEKIHEQEKIREE 469
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/146 (21%), Positives = 91/146 (62%), Gaps = 15/146 (10%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK-SKEKDKVKE 561
E K+++++ K+ E ++K++++ + +++EK R++E + ++K ++++K+ E
Sbjct: 602 EQEEKMWKQEEKIR---EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 658
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
+E+ + ET + +E ++E+E KI+E E+ K++ ++ ++++++EK +++
Sbjct: 659 QEEKMQEQEETMWRQEEKIREQEK-----KIREQEE---KIREQEEMMQEQEEKMWEQE- 709
Query: 622 DREKGKKDKDKREKEKVKDKGREDKM 647
EK + ++K ++++ K + +E+KM
Sbjct: 710 --EKMCEQEEKMQEQEEKMRRQEEKM 733
Score = 40.0 bits (92), Expect = 0.010
Identities = 30/151 (19%), Positives = 80/151 (52%), Gaps = 23/151 (15%)
Query: 503 EPLHKVYEEKTKL---PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKS--KEKD 557
E K+ E++ K+ + ++++ +E + KM ++E++ + EK + ++++ ++++
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675
Query: 558 KVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHK 617
K++E+EK E +E ++E+E K+ E E+ K E+ +
Sbjct: 676 KIREQEKKIREQEEKIREQEEMMQEQEE-----KMWEQEE-------------KMCEQEE 717
Query: 618 DKKKDREKGKKDKDKREKEKVKDKGREDKMK 648
++ EK ++ ++K +++V+ + +E+KM+
Sbjct: 718 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 33.1 bits (74), Expect = 1.2
Identities = 28/121 (23%), Positives = 73/121 (60%), Gaps = 16/121 (13%)
Query: 501 TPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRE---REKDKNKDKSKEKD 557
T E K+ E++ K+ E ++K++++ +T +++EK R++E RE++ +K +E++
Sbjct: 642 TQEQEEKMGEQEEKM---CEQEEKMQEQEETMWRQEEKIREQEKKIREQE---EKIREQE 695
Query: 558 KVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHK 617
++ +++++K +E K +E +E+ + K + +E + + +V+L R+++EK +
Sbjct: 696 EMMQEQEEKMWEQEEKMCEQEEKMQEQEE--KMRRQEEKMWEQEVRL-----RQQEEKMQ 748
Query: 618 D 618
+
Sbjct: 749 E 749
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/256 (20%), Positives = 142/256 (55%), Gaps = 7/256 (2%)
Query: 503 EPLHKVYEEKTKLPSSVEV----KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDK 558
E K+ E++ K+ E+ ++K++++ + +K+EK R+ E + + + ++++K
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 365
Query: 559 VKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEK--EKH 616
+E+EK +E + + K + +EE+ + KI+E E++ + + K G ++EK E+
Sbjct: 366 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG-EQEEKMWEQE 424
Query: 617 KDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPA 676
++ ++ EK ++ ++K +++ K + +E+K++ + +++
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484
Query: 677 MLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKE 736
+ EK+ E+++K++E+E+K ++E+ ++++EK +++E+ E+ E+ + ++E
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 544
Query: 737 KEKHKHEKIKVEPVAL 752
K + + EK++ + V L
Sbjct: 545 KMRRQEEKMREQEVRL 560
Score = 68.6 bits (166), Expect = 3e-11
Identities = 58/243 (23%), Positives = 132/243 (54%), Gaps = 11/243 (4%)
Query: 510 EEKTKLPSSVEVKKKLK-KELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKET 568
EEK + + +K+ K +EL+ KM ++EK R++E EK + ++K +E++K +E+E
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE-EKRQEEEKIREQEKRQEQEAKMWR 387
Query: 569 GRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKK 628
E +E ++E+E + + K E + + ++ + +E++ + ++K RE+ KK
Sbjct: 388 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKK 447
Query: 629 DKDKREKEKVKDK---GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVL 685
+++ EK + +++ +E+KM + ++ +
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 686 PEKLFEEKEKVKEKEKKKDKKEKK--KKKEKEKEKKEKEREKEKREREK----REKEKEK 739
EK+ E++E ++E+E+K ++E+K +++EK +E++EK R +E++ RE+ R++E++
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Query: 740 HKH 742
+H
Sbjct: 568 QEH 570
Score = 67.8 bits (164), Expect = 5e-11
Identities = 54/249 (21%), Positives = 140/249 (56%), Gaps = 33/249 (13%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKL-KKELKTKMKKKEKQRDREREKDKNKDKSKEKD-KVK 560
E K+ E + K+ +++++ K++ + K++++EK++++E + + ++K +E++ K++
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Query: 561 EKEK-----DKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEK 615
E+E+ +++ G + + W++ EEE + K++ E+ K++ ++ +R+++EK
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQ---EEEMQEQEEKMRRQEE---KIREQEKKIREQEEK 454
Query: 616 HKDKKK----DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATA 671
+++++ EK + + K +++ K + +E+KM+ + K++
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ------- 507
Query: 672 SRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEK--EKKEKEREKEKRE 729
+ E + E++EK+ E+E+K ++E+K ++++EK ++EK RE+E R
Sbjct: 508 -------EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRL 560
Query: 730 REKREKEKE 738
R++ EK +E
Sbjct: 561 RQQEEKMQE 569
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/240 (20%), Positives = 125/240 (52%), Gaps = 18/240 (7%)
Query: 520 EVKKKLKKELKTKM-KKKEKQRDREREKDKNKDKSKEKDKVKEK------EKDKETGRET 572
E+ +L ++ + KM +++EK ++RE + + ++K +E+++ + EK+++ R+
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 573 KYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK--KDREKGKKDK 630
+ W++ K E + + ++ + + K + ++ + +EK + ++ K + EK ++ +
Sbjct: 337 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 396
Query: 631 DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLF 690
+K +++ + +E+KM + +E+ + EK+
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 691 EEKEKVKEKEKKKDKKEKK---------KKKEKEKEKKEKEREKEKREREKREKEKEKHK 741
E++E ++E+E+K ++E K +++EK + ++EK RE+EK+ RE+ EK +E+ +
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Score = 59.3 bits (142), Expect = 2e-08
Identities = 53/255 (20%), Positives = 138/255 (54%), Gaps = 23/255 (9%)
Query: 505 LHKVYEEKT-KLPSSVEVKKKLKKELKTKMKKKEKQRDREREK---DKNKDKSKEKDKVK 560
L++ EEK + ++ +++ +E + K++++E ++ R +E+ +K + ++++ +
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQE-EKMRRQEEMMWEKEEKMRRQEEMMW 340
Query: 561 EKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFE---DVDPKVKLKDGLVRKEKEKHK 617
EKE+ E + ++ ++EE + KI+E E + + K+ ++ +R+++EK +
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Query: 618 DK----KKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASR 673
++ ++ EK + ++K +++ + + +E+KM+ + K++
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI-------REQEE 453
Query: 674 VPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEK----EKKEKEREKEKRE 729
++ EK+ E++ K+ E+E K ++E+K ++++EK EKK +E+E++ RE
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 513
Query: 730 REKREKEKEKHKHEK 744
+E+ +E+E+ E+
Sbjct: 514 QEEMMQEQEEKMWEQ 528
Score = 55.1 bits (131), Expect = 3e-07
Identities = 50/233 (21%), Positives = 120/233 (51%), Gaps = 44/233 (18%)
Query: 510 EEKTKLPSSVEVKKKLK-KELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKET 568
+EK +L S + + +L KELK K+++ + +++ + + KE V K + +
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 569 GRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKK 628
E W +++E ++ + K ++ + K++ ++ +R+++EK + ++++ K+
Sbjct: 275 ENEL---WNRLNQQQEEKMWRQEEK-IQEREEKIQEQEEKIREQEEKMR-RQEEMMWEKE 329
Query: 629 DKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEK 688
+K +R++E + +K E+K++ L EK
Sbjct: 330 EKMRRQEEMMWEK--EEKIRE-----------------------------------LEEK 352
Query: 689 LFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK 741
+ E+ EK++E+E+K+ ++EK +++EK +E++ K +E++ RE+ EK +E+ +
Sbjct: 353 MHEQ-EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 404
Score = 54.7 bits (130), Expect = 4e-07
Identities = 44/173 (25%), Positives = 91/173 (52%), Gaps = 12/173 (6%)
Query: 577 KEFLKEEEA---DPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKR 633
+E KE +A + Y+ I + E + KL++ L E EK + + +E KR
Sbjct: 184 EELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL------KR 237
Query: 634 EKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEK 693
+ E+ K + +++A A L + ++ L + + + L EK++ ++
Sbjct: 238 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE---LWNRLNQQQEEKMWRQE 294
Query: 694 EKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
EK++E+E+K ++E+K ++++EK ++++E EK E+ +R++E K EKI+
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347
Score = 38.5 bits (88), Expect = 0.029
Identities = 41/178 (23%), Positives = 87/178 (48%), Gaps = 21/178 (11%)
Query: 581 KEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKD 640
++++AD Y ++ + D ++L + E+ K K+ K K + EK +++
Sbjct: 175 QKKKADRYIEELTKERDA-LSLELYRNTITDEELKEKNAKLQE---KLQLVESEKSEIQL 230
Query: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFE--------- 691
+E K K L+LP ++L A A + L S+ L ++ E
Sbjct: 231 NVKELKRKLERAKLLLPQQQLQ------AEADHLGKELQSVSAKLQAQVEENELWNRLNQ 284
Query: 692 -EKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE 748
++EK+ +E+K ++E+K ++++EK +E+E + ++E EKE++ + E++ E
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEK-IREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 341
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 76.6 bits (187), Expect = 1e-13
Identities = 60/252 (23%), Positives = 142/252 (56%), Gaps = 22/252 (8%)
Query: 507 KVYEEKTKLPSSVEVKKKLKK-ELKTKM--------KKKEKQRDREREKDKNKDKSKEKD 557
K+ E++ K +++++ K+ E + KM +++EK R++E + + ++K E++
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511
Query: 558 KVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHK 617
K++E+EK +E +E + +E ++E+E + ++ K K E + K ++ + R+E++ H
Sbjct: 512 KIREEEKRQE--QEEMWRQEEKIREQE-EIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 618 DKKKDREKGKKDKDKREKEKVKD---KGREDKMKAPAPPLVLPPKELALPLFSPATASRV 674
++K RE+ ++K R++EK+++ K RE + K + +E + +
Sbjct: 569 QEEKIREQ--EEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE 626
Query: 675 PAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKRE 734
M EK+ ++EK++E+EKK ++E+K ++++E ++++E+ E+ E+ +
Sbjct: 627 EKMQEQ-----EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 681
Query: 735 KEKEKHKHEKIK 746
+EK + + EK++
Sbjct: 682 EEKMQEQEEKMR 693
Score = 74.3 bits (181), Expect = 5e-13
Identities = 51/244 (20%), Positives = 140/244 (57%), Gaps = 30/244 (12%)
Query: 508 VYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKS--KEKDKVKEKEKD 565
++E++ K+ E + +K + + K++E+++ RE+EK + ++ ++++K++E+E+
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDV---DPKVKLKDGLVRKEKEKHKDKKKD 622
E + +E + E+E + K +E E++ + K++ ++ + R++++ H+ ++K
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Query: 623 REKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLL 682
R+ +++K R++EK+ D +E+K++ + +++
Sbjct: 553 RK--QEEKMWRQEEKMHD--QEEKIREQEEKVWRQEEKIR-------------------- 588
Query: 683 PVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKH 742
EK+ E++EK++E+E+ ++E+K +++EK +++E+ +E+ E+ +R++EK + +
Sbjct: 589 -EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647
Query: 743 EKIK 746
+KI+
Sbjct: 648 KKIR 651
Score = 69.7 bits (169), Expect = 1e-11
Identities = 55/245 (22%), Positives = 131/245 (53%), Gaps = 29/245 (11%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEK 562
E K+ E++ K+ E ++K++++ + +K+EK R +E + ++K + ++++ +
Sbjct: 379 EQEEKIREQEEKIR---EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 435
Query: 563 EKDKETGRETKYPWKEFLKE-EEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
+++K E K +E ++E EE + KI+E E + + + + R+E++ + ++K
Sbjct: 436 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK---RQEQEAKMWRQEEKIREQEEK 492
Query: 622 DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSL 681
RE+ +K + EK ++K RE++ + + +++
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR------------------- 533
Query: 682 LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK 741
E+++ +KEK+ E+E+K K+E+K +++EK ++E+ +E+ E+ R++EK + +
Sbjct: 534 ---EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ 590
Query: 742 HEKIK 746
EKI+
Sbjct: 591 EEKIR 595
Score = 67.8 bits (164), Expect = 5e-11
Identities = 56/249 (22%), Positives = 133/249 (53%), Gaps = 48/249 (19%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRER-EKDKNKDKSKEKDKVKE 561
E L V EK+++ +V+ K+ + K + +++ Q + + K+ +K + +V+E
Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 348
Query: 562 KEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKK 621
E ++ + K + +EE+ ++ KI+E E+ K++ ++ +R+++EK + +++
Sbjct: 349 NELWNRLNQQQEE--KMWRQEEKIQEWEEKIQEQEE---KIREQEEKIREQEEKMR-RQE 402
Query: 622 DREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSL 681
+ K++K +R++E + +K E+KM+
Sbjct: 403 EMMWEKEEKMRRQEEMMWEK--EEKMRRQE------------------------------ 430
Query: 682 LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREK----REKEK 737
E ++E++EK++E E+K ++EK +++E++++++EK RE+EKR+ ++ R++EK
Sbjct: 431 -----EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 485
Query: 738 EKHKHEKIK 746
+ + EKI+
Sbjct: 486 IREQEEKIR 494
Score = 66.2 bits (160), Expect = 1e-10
Identities = 47/239 (19%), Positives = 126/239 (52%), Gaps = 33/239 (13%)
Query: 520 EVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK-- 577
E+ +L ++ + KM ++E++ EK + +++ + + K +E++++ R+ + W+
Sbjct: 350 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE 409
Query: 578 -------EFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDK 630
E + E+E + + +E + +L++ + +EK + +++K+ E+ +++
Sbjct: 410 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 469
Query: 631 DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLF 690
+KR++++ K +E+K++ + +++ E+
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ----------------------EEKI 507
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEK--REREKREKEKEKHKHEKIKV 747
E+EK++E+EK+++++E +++EK +E++E R+KEK + EK K++EK ++ K+
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKM 566
Score = 64.7 bits (156), Expect = 4e-10
Identities = 53/244 (21%), Positives = 136/244 (55%), Gaps = 23/244 (9%)
Query: 503 EPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEK 562
E K++ ++ K+ +++++ K++ + +M ++E++ + E + K+K E+++ K
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 563 EKDKETGRETK-YPWKEFLKEEEADPYKF--KIKEFEDVDPKVKLKDGLVRKEKEKHKDK 619
+++K +E K + +E ++E+E ++ KI+E E+ K++ ++ +R+++E +++
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE---KIREQEEKIREQEEMTQEQ 611
Query: 620 KKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLP 679
+ EK + ++K +++ K + +E+KM+ + K++
Sbjct: 612 E---EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIR-------EQEEKIREQE 661
Query: 680 SLLPVLPEKLFEEKEKVKEKEKK-KDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKE 738
++ EK++E++EK+ E+E+K ++++EK +++E EK E+E R R++ EK +E
Sbjct: 662 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE------EKMWEQEVRLRQQEEKMQE 715
Query: 739 KHKH 742
+H
Sbjct: 716 HQEH 719
Score = 45.4 bits (106), Expect = 2e-04
Identities = 45/185 (24%), Positives = 93/185 (50%), Gaps = 19/185 (10%)
Query: 577 KEFLKEEEA---DPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKR 633
+E KE +A + Y+ I + E + KL++ L E EK + + +E KR
Sbjct: 257 EELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL------KR 310
Query: 634 EKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATAS----RVPAMLPSLLPVLPEKL 689
+ E+ K + +++A A L + ++ L + + R+ + EK+
Sbjct: 311 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 370
Query: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKR------EKEKEKHKHE 743
E +EK++E+E+K ++E+K ++++EK ++++E EK E+ +R EKE++ + E
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 430
Query: 744 KIKVE 748
++ E
Sbjct: 431 EMMWE 435
Score = 39.7 bits (91), Expect = 0.013
Identities = 56/265 (21%), Positives = 122/265 (46%), Gaps = 50/265 (18%)
Query: 505 LHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDR------------EREKDKNKDK 552
LH ++ +L ++ KK+ +++ K+RD E K+KN K
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA-K 286
Query: 553 SKEKDKVKEKEKD------KETGRETKYPWKEFLKEEEADPYKFKI-KEFEDVDPKVKLK 605
+EK ++ E EK KE R+ + K L +++ + KE + V K++ +
Sbjct: 287 LQEKLQLVESEKSEIQLNVKELKRKLERA-KLLLPQQQLQAEADHLGKELQSVSAKLQAQ 345
Query: 606 DGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPL 665
V + + ++ ++ EK + ++K ++ + K + +E+K++ + +++
Sbjct: 346 ---VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ- 401
Query: 666 FSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEK--EKKEKER 723
E ++E++EK++ +E+ +KE+K ++++E EK+EK R
Sbjct: 402 --------------------EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 724 EKEKREREKREKEKEKHKHEKIKVE 748
E E++ E+EK + + EK + E
Sbjct: 442 ELEEK---MHEQEKIREQEEKRQEE 463
Score = 33.1 bits (74), Expect = 1.2
Identities = 25/124 (20%), Positives = 71/124 (57%), Gaps = 10/124 (8%)
Query: 501 TPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVK 560
T E K+ E++ K+ E ++ +++++ + +K +Q + RE++ +K +E++++
Sbjct: 608 TQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE---EKIREQEEMM 664
Query: 561 EKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKK 620
+++++K +E K +E +E+ + K + +E + + +V+L R+++EK ++ +
Sbjct: 665 QEQEEKMWEQEEKMCEQEEKMQEQEE--KMRRQEEKMWEQEVRL-----RQQEEKMQEHQ 717
Query: 621 KDRE 624
+ E
Sbjct: 718 EHLE 721
>gi|38788274 bromodomain PHD finger transcription factor isoform 1
[Homo sapiens]
Length = 2920
Score = 74.7 bits (182), Expect = 4e-13
Identities = 146/698 (20%), Positives = 261/698 (37%), Gaps = 172/698 (24%)
Query: 268 FTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKT-VSKEKKSPGRSKSPKSPKSPKV 326
FTP T T++ T TA SP+ V ++K P S P +
Sbjct: 2211 FTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQP 2270
Query: 327 TTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPD-------AGKLNSENQPKK 379
T P +P+T ++P+ ++QT P+ + + SE QP
Sbjct: 2271 QTAQPSAQPQPQTQPQSPAQP-------------EVQTQPEVQTQTTVSSHVPSEAQPTH 2317
Query: 380 AVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKASTS 439
A + + A+ +P S +G SP R+ P T + ST
Sbjct: 2318 AQSSKPQV-----------AAQSQPQ-------SNVQGQ---SPVRVQSPSQTRIRPSTP 2356
Query: 440 A-------NNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYI 492
+ + + S P+P+ TS S S +V + S N +
Sbjct: 2357 SQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQT-LSSGQTLNQVTV 2415
Query: 493 SSPS-----VSPPTPE-----PLHKVYEEKTKLPSSVE---------VKKKLKKELKTKM 533
SSPS + P P+ L + + +++ S V V +++K +L ++
Sbjct: 2416 SSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQI 2475
Query: 534 KKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIK 593
++ + + + + +++++ ++ ++ ++ K E +E
Sbjct: 2476 QQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASN---- 2531
Query: 594 EFEDVDPKVKLK-DGLVRKEKEKHKDKKKDREKGKK------------DK-DKREKEKVK 639
+ E + +V +K + ++ K+K +RE+ ++ DK DK EK+ K
Sbjct: 2532 QSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAK 2591
Query: 640 DKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEK 699
+ RE+ ++ S A+++ A+L F+ KE+++ +
Sbjct: 2592 KRKREESVEQKR---------------SKQNATKLSALL-----------FKHKEQLRAE 2625
Query: 700 EKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIP 759
KK + +K+ + E +E KR+ + +K K + A+A +P P
Sbjct: 2626 ILKK------------RALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVA-APCPP 2672
Query: 760 RLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLA 819
V PAP A PAP P +PPP PA +L +P LP
Sbjct: 2673 -----------------VTPAPPAPPAP----PPSPPPPPAVQHTGLLSTPT---LP--- 2705
Query: 820 QAAAGPALLPSPGPAASGASAKAPVRSVVTET---VSTYVIRDEWGNQIWICPGCNKPDD 876
AA+ ++S + K + + ET Y I C P D
Sbjct: 2706 -AASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCI-------------CKTPYD 2751
Query: 877 GSPM-IGCDDCDDWYHWPCVGIMTAPPEEM-QWFCPKC 912
S IGCD C +WYH CVGI+ + E + ++ CP+C
Sbjct: 2752 ESKFYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQC 2789
Score = 48.1 bits (113), Expect = 4e-05
Identities = 109/539 (20%), Positives = 198/539 (36%), Gaps = 88/539 (16%)
Query: 217 SSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQMPTAKPLETKSFTPKTKTKT 276
SS+ + P + Q P SP P + + Q T S T ++
Sbjct: 2261 SSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQS 2320
Query: 277 SSP----GQKTKSPKTAQSPAMVGSPIRS---PKTVSKEKKSPGR------SKSPKSPKS 323
S P + +S QSP V SP ++ P T S + SPG+ + S P
Sbjct: 2321 SKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPS--QLSPGQQSQVQTTTSQPIPIQ 2378
Query: 324 PKVTTHIP---QTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKA 380
P + IP Q +P+ + T + + + +++ T+ + P +L + QP+
Sbjct: 2379 PHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTV------SSPSRPQLQIQ-QPQPQ 2431
Query: 381 VVADKTIEASIDA-------VIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTT 433
V+A ++ + V+A+ A++ P + P +I + +
Sbjct: 2432 VIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIK---------LQLPIQIQ--QSSA 2480
Query: 434 PKASTSANNFT-KSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYI 492
+ N T ++ S L D E+ R+ L N I
Sbjct: 2481 VQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTL-----QASNQSEI 2535
Query: 493 SSPSVSPPTPEPLHKVYEEKTKLPSSVE------VKKKLKKELKTKMKKKEKQRDREREK 546
V + + ++K+ P+ E V ++ K + K+ K+EKQ ++R++
Sbjct: 2536 IQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKR 2595
Query: 547 DKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKD 606
+++ ++ + K TK F +E+ K + D D ++++++
Sbjct: 2596 EESVEQKRSKQNA------------TKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQE 2643
Query: 607 GLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLF 666
L K+D K KK+KD + + + AP PP+ P P
Sbjct: 2644 EL-----------KRDL-KIKKEKD------LMQLAQATAVAAPCPPVTPAPPAPPAPPP 2685
Query: 667 SPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREK 725
SP V P LP +++ +E+EK K KKKK K+ K+ K
Sbjct: 2686 SPPPPPAVQHTGLLSTPTLPA---ASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTK 2741
Score = 32.7 bits (73), Expect = 1.6
Identities = 19/58 (32%), Positives = 30/58 (51%)
Query: 658 PKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKE 715
P+E AL L A + MLP L ++ +EK+K KK++KK++E+E
Sbjct: 817 PREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEE 874
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 74.7 bits (182), Expect = 4e-13
Identities = 63/268 (23%), Positives = 132/268 (49%), Gaps = 38/268 (14%)
Query: 493 SSPSVSPPTPEP--LHKVYEEKTKLPSSVEVKKKLKKELKTKM-------KKKEKQRDRE 543
S S P EP L E+ + S+ + ++ E+K+K +++EK+R+RE
Sbjct: 522 SQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERE 581
Query: 544 REKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEAD---PYKFKIKEFEDVDP 600
RE++K K++ +EK K+KE EK++++ ++ + + +++EA+ K ++K+ ++
Sbjct: 582 REREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641
Query: 601 KVKLKDGLVRKEKEKHKDK----------------KKDREKGKKDKDKREKEKVKDKGRE 644
++KL + R ++ +DK + R K +DK+K+E +K+ D+
Sbjct: 642 EMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDAL 701
Query: 645 DKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLP---EKLFEEKEKVKEKEK 701
K++A + K+LA+ A + L S + V E + E+ ++ ++ +
Sbjct: 702 RKIRAVEEQIEYLQKKLAM-------AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLR 754
Query: 702 KKDKKEKKKKKEKEKEKKEKEREKEKRE 729
+KD K E+ K + + KE++E
Sbjct: 755 EKDDANFKLMSERIKSNQIHKLLKEEKE 782
Score = 58.2 bits (139), Expect = 4e-08
Identities = 53/233 (22%), Positives = 114/233 (48%), Gaps = 19/233 (8%)
Query: 524 KLKKE-LKTKMKKKEKQRDREREK--------DKNKDKSKEKDKVKEKEKDKETGRETKY 574
+LK E L+ K K +E Q D + + KD+ E + D E
Sbjct: 489 QLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSS 548
Query: 575 PWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE 634
K +E+A+ K K E E+ + + + K+ +E+EK K+++++++K K+ + +R+
Sbjct: 549 ASKA--SQEDANEIKSKRDE-EERERERREKEREREREREKEKEREREKQKLKESEKERD 605
Query: 635 KEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKE 694
K K+KG+ D + ++ K+L + L + + +L + P+ E+++
Sbjct: 606 SAKDKEKGKHDDGRKKEAEII---KQLKIELKKAQESQKEMKLLLDMYRSAPK---EQRD 659
Query: 695 KVK-EKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIK 746
KV+ +KK K E + +++ K+ ++KE+++ K+ ++ K + E+I+
Sbjct: 660 KVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIE 712
Score = 54.7 bits (130), Expect = 4e-07
Identities = 61/239 (25%), Positives = 105/239 (43%), Gaps = 37/239 (15%)
Query: 517 SSVEVKKKLKKELKTKMKKKEKQRDRER--EKDKNKDKSKEKDKVKEKEK-DKETGRETK 573
SS E K ELK + Q + ++D N+ KSK ++ +E+E+ +KE RE
Sbjct: 524 SSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERE-- 581
Query: 574 YPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKR 633
+E KE+E + K K+KE EK +D KD+EKGK D ++
Sbjct: 582 ---REREKEKEREREKQKLKE------------------SEKERDSAKDKEKGKHDDGRK 620
Query: 634 EKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEK 693
++ ++ + + + KA KE+ L L +A + L+ E+K
Sbjct: 621 KEAEIIKQLKIELKKAQESQ-----KEMKLLLDMYRSAPKEQRDKVQLMAA------EKK 669
Query: 694 EKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVAL 752
K + ++ ++ K+ + K++KE +K E K + + E + K K E AL
Sbjct: 670 SKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEAL 728
Score = 53.1 bits (126), Expect = 1e-06
Identities = 33/104 (31%), Positives = 64/104 (61%), Gaps = 3/104 (2%)
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHK-HEKIKVEP 749
E K K E+E++++++EK++++E+E+E KEKERE+EK++ ++ EKE++ K EK K +
Sbjct: 559 EIKSKRDEEERERERREKERERERERE-KEKEREREKQKLKESEKERDSAKDKEKGKHDD 617
Query: 750 VALAPSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPK 793
+ +I +L + + Q+ K++ + AP + R K
Sbjct: 618 GRKKEAEIIKQLKIELKKAQESQKEMKLL-LDMYRSAPKEQRDK 660
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/85 (29%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 665 LFSPATASRVPAMLPSLLPVLPEKLFEEKEKVK-EKEKKKDKKEKKKKKEKEKEKKEKER 723
L +++ P P+ L E L + K +E + K K+ ++E+E+E++EKER
Sbjct: 519 LLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKER 578
Query: 724 EKEKREREKREKEKEKHKHEKIKVE 748
E+E+ +++E+E+EK K ++ + E
Sbjct: 579 EREREREKEKEREREKQKLKESEKE 603
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/234 (20%), Positives = 95/234 (40%), Gaps = 60/234 (25%)
Query: 538 KQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFED 597
K++ RE + D NK + + + + + E ++ K ++ + K + ED
Sbjct: 498 KRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQ-ED 556
Query: 598 VDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLP 657
+ + K K +++++RE+ +K+++ RE+E+ K+K RE
Sbjct: 557 AN-----------EIKSKRDEEERERERREKERE-REREREKEKERE------------- 591
Query: 658 PKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKE 717
EK+K+KE EK++D K K+K K +
Sbjct: 592 ---------------------------------REKQKLKESEKERDSA-KDKEKGKHDD 617
Query: 718 KKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRVGAGQDK 771
++KE E K+ + + +K +E K K+ ++ AP ++ L + K
Sbjct: 618 GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSK 671
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 73.9 bits (180), Expect = 6e-13
Identities = 68/275 (24%), Positives = 133/275 (48%), Gaps = 36/275 (13%)
Query: 510 EEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETG 569
EE+ ++ + + ++ +K + K+ ++R R R +++ K K +E+ + K+ E+ K
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399
Query: 570 RETKYPWK--------EFLKEEEADPYKFKI----KEFEDVDPKVKLKDGLVRKEKEKHK 617
+ETK + +++ E++A K + K+ E+ KV+ K ++++K K
Sbjct: 400 QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
Query: 618 DKKKDREKGKKDKDKREKEK-----------VKDKGRE---DKMKAPAPPLVLPPKELAL 663
++ EK KKDK+ +E+ K VK + E K+K P ++
Sbjct: 460 KEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
Query: 664 PLFSPATASRVPA--MLPSLLPVLPEKLFEEKEKVKEK--------EKKKDKKEKKKKKE 713
A +V A L L E EE EK+K+K E+ K K+E+++K
Sbjct: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVL 579
Query: 714 KEKEKKEKEREKEKREREKREKEKEKHKHEKIKVE 748
+E+E++ K+ E +++ RE+ EK + K + E+ + E
Sbjct: 580 EEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAE 614
Score = 69.3 bits (168), Expect = 2e-11
Identities = 62/267 (23%), Positives = 126/267 (47%), Gaps = 13/267 (4%)
Query: 490 PYISSPSVSPPTPEPLHKVYEEKT-----KLPSSVEVKKKLKKELKTKMKKKEKQRDRER 544
P I+ S+S P+ + E +T K S E + + E TK +K RD E
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
Query: 545 EKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKL 604
K ++K+K +E+++ ++ E E K +EE K + +PK +
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242
Query: 605 KDGLVRKEKEKH-KDKKKDREKGKKDKDKRE-KEKVKDKGREDKMKAPAPPLVLPPKELA 662
+ E H K +++D+E+ + ++ + E +E+ + K +DK A + ++ A
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAA 302
Query: 663 LPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKE 722
A M ++ EE++++KE+EK+ ++ ++ K+E+++ +E++
Sbjct: 303 AQERERREAEERERMREE-----EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 723 REKEKREREKREKEKEK-HKHEKIKVE 748
R KE+ +R E+++ + + EK KVE
Sbjct: 358 RIKEEEKRAAEERQRARAEEEEKAKVE 384
Score = 54.7 bits (130), Expect = 4e-07
Identities = 51/242 (21%), Positives = 106/242 (43%), Gaps = 66/242 (27%)
Query: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
+ +++ E K +++E++ ERE+ + ++K +++ + KE++K E ++ +K
Sbjct: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEE-----RQRIK 346
Query: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREK--EKVK 639
EEE + + ++K+ R +E+ + + ++ EK K ++ KR K E+ K
Sbjct: 347 EEEK----------RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK 396
Query: 640 DKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEK 699
+E K+K EKV++K
Sbjct: 397 HAMQETKIKG--------------------------------------------EKVEQK 412
Query: 700 EKKKDKKEKKKKKEK-----EKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAP 754
+ K EKK +++K K++ E++ K + +REK +++K K E+IK E +
Sbjct: 413 IEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 472
Query: 755 SP 756
P
Sbjct: 473 EP 474
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/231 (22%), Positives = 106/231 (45%), Gaps = 37/231 (16%)
Query: 523 KKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKE 582
++L + + + K+ ++ +R++E D + + + D T+ K ++
Sbjct: 98 ERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ 157
Query: 583 EEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKK-DKDKREKEKVKDK 641
E +++I+E E V K K+ +D E+ KK DK+K E+E+ K K
Sbjct: 158 E-----RYEIEETETVT-------------KSYQKNDWRDAEENKKEDKEKEEEEEEKPK 199
Query: 642 GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701
+ ++ + + T S+ ++ SL + EE ++ +E+E+
Sbjct: 200 RGS-----------IGENQVEVMVEEKTTESQEETVVMSLKN--GQISSEEPKQEEEREQ 246
Query: 702 KKDK-KEKKKKKEKEKEKKEKER---EKEKREREKREKEKEKHKHEKIKVE 748
D+ +K +E++KE+ E ER E E+RER K E++K K E+ ++E
Sbjct: 247 GSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK-KIADERARIE 296
Score = 37.7 bits (86), Expect = 0.050
Identities = 47/279 (16%), Positives = 119/279 (42%), Gaps = 48/279 (17%)
Query: 520 EVKKKLKKELKTKMKKKEKQR--DREREKDKNKDKSKEKDKVKEKEKDKETGRET---KY 574
E++++ ++E++ + ++ QR D E E + + + ++++++K++++ G+ T +
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
Query: 575 PWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKRE 634
+ + +EEA + + D + + L R+E+ R+K ++ +R+
Sbjct: 69 NAQNSVPDEEAKTTTTNTQV--EGDDEAAFLERLARREER--------RQKRLQEALERQ 118
Query: 635 KEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKE 694
KE F P T + LPS + E E
Sbjct: 119 KE-----------------------------FDP-TITDASLSLPSRRM---QNDTAENE 145
Query: 695 KVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAP 754
+++EK + ++E+ + +E E K ++ + E ++++KEK + E+ K + ++
Sbjct: 146 TTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE 205
Query: 755 SPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPK 793
+ V + + Q++ V+ + + P Q +
Sbjct: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
Score = 32.7 bits (73), Expect = 1.6
Identities = 11/56 (19%), Positives = 35/56 (62%)
Query: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKI 745
FE + +++ +++++ + E ++ + + E+E +E+R R ++E+ ++K + E +
Sbjct: 4 FERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
Score = 31.6 bits (70), Expect = 3.6
Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 9/74 (12%)
Query: 115 KDAEERKEYIPDYLPPIVSSQEEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDEN 174
+DAEE K+ ++EEEEE+ P G ++V +EE +EE +
Sbjct: 178 RDAEENKKE---------DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
Query: 175 FLGKRPLDSPEAEE 188
G+ + P+ EE
Sbjct: 229 KNGQISSEEPKQEE 242
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
Length = 1341
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/139 (29%), Positives = 80/139 (57%), Gaps = 6/139 (4%)
Query: 610 RKEKEKHKDKKKDREKGK-KDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSP 668
R E+E +DK ++ + + + +D+R KE+ K K ++ + K A PP +L LF
Sbjct: 1160 RSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEE--PPAKLLDDLFRK 1217
Query: 669 ATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKE---KKEKEREK 725
A+ LP + +K E E+ KE+EK++ ++E++++KE+EKE ++ ++ E+
Sbjct: 1218 TKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLER 1277
Query: 726 EKREREKREKEKEKHKHEK 744
EKR RE+++E+ + +
Sbjct: 1278 EKRREHSRERDRERERERE 1296
Score = 67.0 bits (162), Expect = 8e-11
Identities = 118/642 (18%), Positives = 241/642 (37%), Gaps = 103/642 (16%)
Query: 138 EEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDENFLGKRPLDSPEAEELPAMKRPRL 197
EE+E+V D + VP E +++ ND+ RP S E EE P+
Sbjct: 767 EEKEEVTMDTSENRPENDVP--EPPMPIADQVSNDD-----RPEGSVEDEEKKESSLPKS 819
Query: 198 LSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLAPPSPEPPMLAPVAKSQM 257
K + VV P + +T+ P ST P + KS +
Sbjct: 820 FKRK---ISVVSATKGVPAGNSDTEGGQPGRKR-RWGASTATTQKKPSISITTESLKSLI 875
Query: 258 PTAKPL-----------ETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVS 306
P KPL + + + G K K ++ V P +
Sbjct: 876 PDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQV-VPAEGQENGQ 934
Query: 307 KEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPP 366
+E++ + + P P+V+ + + P + TL + +++ +I ++
Sbjct: 935 REEEEEEKEPEAEPPVPPQVSVEVA---LPPPAEHEVKKVTLGDTLTRRSISQQK----- 986
Query: 367 DAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRI 426
+G + + P + I ++ + R PF E G T +
Sbjct: 987 -SGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVR---PFTLGQLKELLGRTGTLVEEA 1042
Query: 427 SGPECTTPKASTSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDE-----VVRKAKLGT 481
+ + + ++ +T L G N + A E R +
Sbjct: 1043 FWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDR 1102
Query: 482 PSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRD 541
PS I P + PP P P+ P ++ ++E + + E++R+
Sbjct: 1103 PSETKTEEQGIPRP-LHPPPPPPVQ---------PPQHPRAEQREQERAVREQWAERERE 1152
Query: 542 REREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPK 601
ER + ++ ++DKV+E + + R+ + + KE++++ KE +P
Sbjct: 1153 MERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEK-----KEKAQEEPP 1207
Query: 602 VKLKDGLVRKEK------------EKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKA 649
KL D L RK K + K+ +R + K+++KR KE+ +++ +E + +A
Sbjct: 1208 AKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEA 1267
Query: 650 PAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKK 709
+E L E+EK +E +++D +E++
Sbjct: 1268 E--------RERNRQL--------------------------EREKRREHSRERD-RERE 1292
Query: 710 KKKEKEKEKKEKEREKEK-REREKREKEKEKHKHEKIKVEPV 750
+++E+++ ++++RE+++ R RE+ ++ ++H + + PV
Sbjct: 1293 RERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPV 1334
Score = 47.8 bits (112), Expect = 5e-05
Identities = 98/486 (20%), Positives = 174/486 (35%), Gaps = 95/486 (19%)
Query: 136 EEEEEEQVPTDGGTSAEAMQVPLEEDDELEEEEIINDE----NFLGKRPLDSP------- 184
EEEE+++ P+ + EE++E EEEE +DE + G++ ++P
Sbjct: 247 EEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKE 306
Query: 185 EAEELPAMKRPRLL----STKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQDSTDLA 240
E EE+P +K ++ T+ +V+ R S +K + LA
Sbjct: 307 EGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARK-------------SHLA 353
Query: 241 PPSPEPPMLAPVAKSQMPTAKPLETK------SFTPKTKTKTSSPGQKTKSPKTAQSPAM 294
E +M T PLE + S K K+K+ SP + T+ K A A+
Sbjct: 354 RQQQE---------KEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVAL 404
Query: 295 VGSPIRSPKTVSKEKKSPGRSKSPKSPKSPKVTTHI---------PQTPVRPE-TPNRTP 344
+T S+E+ P S P H P PV + +P T
Sbjct: 405 ------PEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTD 458
Query: 345 SATLSEKISKETIQVKQIQTPPDAGKLNSENQPKKAVVADKTIEASIDAVIARACAEREP 404
+ T +S+ T+Q+ +P L+S + K A+K E S+ ++ ++
Sbjct: 459 ADTRELLVSQHTVQLVGGLSP-----LSSPSDTKAESPAEKVPEESVLPLVQKSTLA--- 510
Query: 405 DPFEFSSGSESEGDIFTSPKRISGPECTTPKA---------STSANNFTKSGSTPLPLSG 455
+ E E D P + E K S ++ T LP
Sbjct: 511 -DYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHR 569
Query: 456 GTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKL 515
S+D+S + +S +++ +P S + PL + +
Sbjct: 570 LKQSADSSSSRSSSSSSSSSRSRSRSPD------------SSGSRSHSPLRSKQRDVAQA 617
Query: 516 PSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDK------SKEKDKVKEKEKDKETG 569
+ + + K ++ + + + R R R N K S++ + KD +G
Sbjct: 618 RTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSG 677
Query: 570 RETKYP 575
+E P
Sbjct: 678 QEVATP 683
Score = 46.2 bits (108), Expect = 1e-04
Identities = 48/183 (26%), Positives = 84/183 (45%), Gaps = 23/183 (12%)
Query: 510 EEKTKLPSS---VEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKE-KEKD 565
EE + PS V + LK E + + +++E++ D E E D KS+E +KE KE+
Sbjct: 249 EEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEG 308
Query: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREK 625
+E R +K EE + K + E +V + G + +E+ + R++
Sbjct: 309 EEIPR---------VKPEEMMDERPKTRSQEQ---EVLERGGRFTRSQEEARKSHLARQQ 356
Query: 626 GKKDK------DKREKEKVKDKGREDKMKAPAPP-LVLPPKELALPLFSPATASRVPAML 678
+K+ ++ E+E +G ++K K+P+PP L K+ +L TAS
Sbjct: 357 QEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPP 416
Query: 679 PSL 681
P L
Sbjct: 417 PLL 419
Score = 43.5 bits (101), Expect = 0.001
Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 15/122 (12%)
Query: 631 DKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLF 690
D+ + K +++G + P PP V PP+ A R E+
Sbjct: 1101 DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVR-------------EQWA 1147
Query: 691 EEKEKVKEKEKKKDKKEKKKKKEKEKEK-KEKEREKEKREREKREKEKEKHKHEKIKVEP 749
E + +++ +E+ + ++E + K +E + + + R++ ++ER K KEK+ K EK + EP
Sbjct: 1148 EREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK-SKEKKSEKKEKAQEEP 1206
Query: 750 VA 751
A
Sbjct: 1207 PA 1208
Score = 40.8 bits (94), Expect = 0.006
Identities = 65/345 (18%), Positives = 130/345 (37%), Gaps = 36/345 (10%)
Query: 521 VKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKET-------GRETK 573
V L + ++ +++ E + R + + ++ D EK + E R K
Sbjct: 179 VASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAK 238
Query: 574 YPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKR 633
EEE D +E + +V+ L +E+E+ ++++++ ++ ++ D+
Sbjct: 239 LSEGSQPAEEEED------QETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEG 292
Query: 634 EKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEK 693
+K + +E K + P V P + + P T S+ +L + K
Sbjct: 293 QKSREAPILKEFKEEGEEIPRVKPEEMMDE---RPKTRSQEQEVLERGGRFTRSQEEARK 349
Query: 694 EKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALA 753
+ ++++K+ K +E+E+E K + KEK + + E K + P A
Sbjct: 350 SHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTA 409
Query: 754 PSPVIPRLTLRVGAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPV 813
P +++K +P P P PAP P+L+ +P
Sbjct: 410 SEEETP-----------PPLLTKEASSPPPHPQLHSEEEIEPMEGPAP---PVLIQLSPP 455
Query: 814 PLP------LLAQAAAGPALLPSPGPAASGASAKAPVRSVVTETV 852
L++Q SP + S A++P V E+V
Sbjct: 456 NTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESV 500
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,381,790
Number of Sequences: 37866
Number of extensions: 3069877
Number of successful extensions: 127747
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1418
Number of HSP's successfully gapped in prelim test: 1994
Number of HSP's that attempted gapping in prelim test: 30519
Number of HSP's gapped (non-prelim): 42840
length of query: 929
length of database: 18,247,518
effective HSP length: 112
effective length of query: 817
effective length of database: 14,006,526
effective search space: 11443331742
effective search space used: 11443331742
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.